gammadelta T cell subsets: a link between TCR and function?
The gammadelta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gammadelta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gammadelta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gammadelta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus.
O'Brien
Rebecca L
RL
Integrated Dept. of Immunology, National Jewish Health, 1400 Jackson St., Denver, CO 80206, United States; Univ. of Colorado Denver, Aurora, CO 80045, USA. obrienr@njhealth.org
Born
Willi K
WK
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta
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