title: Adiponectin gene SNP276 variants and central obesity confer risks for hyperglycemia in indigenous Taiwanese.
abstract: This cross-sectional study analyzed the effects of two single nucleotide polymorphisms (SNP) of the adiponectin gene, SNP45 and SNP276, on hyperglycemia in indigenous Taiwanese, and whether central obesity modulates the effects of these SNPs. Overall, 550 indigenous Taiwanese were recruited for this cross-sectional study. The subjects were categorized into a hyperglycemic group if fasting plasma glucose was > 126 mg/dL (n = 88) or the control group if fasting plasma glucose was < 100 mg/dL (n = 462). The SNP276 TT homozygote carried greater hyperglycemia risk than SNP276 GG [odds ratio (OR) = 2.67, 95% confidence interval (CI) = 1.05-6.78], but not heterozygote (OR = 1.54, 95% CI = 0.95-2.50). SNP45 T > G was not associated with hyperglycemia risk. In multivariate-adjusted modeling, we found a significant relationship between SNP276 T carriers (GT + TT) (OR = 2.06, 95% CI = 1.10-3.88) and central obesity (OR = 4.50, 95% CI = 1.91-10.61) with hyperglycemia. Compared with non-central-obese carriers of SNP276 GG, non-central-obese SNP276 T carriers, and central obese subjects with SNP276 GG and SNP276 T carriers had 5.50, 8.31 and 13.76-fold, respectively, higher risks for hyperglycemia; obese carriers of the T-containing variants experienced a combined risk for hyperglycemia. Furthermore, the hyperglycemic risks were more pronounced in leaner (non-central-obese) individuals carrying the T variant than the central-obese individuals. The adiponectin SNP276 T variant and central obesity had independent and additive effects on hyperglycemia risks. These findings may provide valuable information regarding preventive strategies that might be useful to prevent or treat diabetes and its related complications.
authors.affiliation: Department of Public Health, Faculty of Medicine, Kaohsiung Medical University, 100 Shi-Chuan 1st Road, Zhunan, Kaohsiung, Taiwan.
authors.forename: Meng-Chuan
authors.initials: MC
authors.lastname: Huang
authors.forename: Tsu-Nai
authors.initials: TN
authors.lastname: Wang
authors.forename: King-Teh
authors.initials: KT
authors.lastname: Lee
authors.forename: Yu-Ju
authors.initials: YJ
authors.lastname: Wu
authors.forename: Hung-Pin
authors.initials: HP
authors.lastname: Tu
authors.forename: Chih-Shan
authors.initials: CS
authors.lastname: Liu
authors.forename: Hung-Che
authors.initials: HC
authors.lastname: Chiang
authors.forename: Ying-Chin
authors.initials: YC
authors.lastname: Ko
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000208:ethnology* / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications* / Q000208:ethnology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology / Q000208:ethnology
chemical_list: D052242:Adiponectin
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