Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected].
A number of factors including inflammation and oxidative stress are believed to play a role in the development of chronic joint diseases. Green tea has become a popular drink and is consumed throughout the world. Extracts of green tea and polyphenols present therein have been shown to inhibit the inflammatory responses in vitro in different cell types and the development of arthritis in animal model studies. There is considerable evidence that (-)-epigallocatechin-3-gallate (EGCG), the predominant green tea polyphenol which mimic its effects, inhibits enzyme activities and signal transduction pathways that play important roles in inflammation and joint destruction in arthritis. After oral consumption EGCG become bioavailable and proteomic studies suggest that EGCG may directly interact with a large set of protein targets and alter the physiological response of the cells. Taken together these and other studies identify and support the use of EGCG as a possible chemopreventive agent with a potential to inhibit the development of arthritis. Here we review the biological effects of EGCG in an attempt to understand its pivotal molecular targets that directly affect the inflammation and joint destruction process for prevention and/or for the development of new therapeutics for arthritis in humans.
Singh
Rashmi
R
Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, India.
Akhtar
Nahid
N
Haqqi
Tariq M
TM
D001168:Arthritis / Q000188:drug therapy*; D002392:Catechin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D005419:Flavonoids / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D010636:Phenols / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D059808:Polyphenols; D013329:Structure-Activity Relationship; D013662:Tea / Q000009:adverse effects / Q000737:chemistry*
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate
Connect Tissue Res. 2002;43(2-3):520-3
12489208
Mol Pharmacol. 1997 Sep;52(3):465-72
9281609
J Rheumatol. 2001 Sep;28(9):1952-9
11550959
J Nutr Biochem. 2002 Feb;13(2):103-111
11834226
Free Radic Biol Med. 2006 Aug 15;41(4):549-56
16863987
Free Radic Biol Med. 2002 Oct 15;33(8):1097-105
12374621
Science. 1995 Apr 28;268(5210):579-82
7725107
J Dermatol Sci. 2005 Dec;40(3):195-204
16102944
J Biol Chem. 2001 Apr 20;276(16):13322-30
11278274
Planta Med. 2006 Jun;72(8):697-702
16739069
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14692-7
18796608
J Clin Invest. 2002 Nov;110(10):1419-27
12438440
FEBS J. 2008 Sep;275(18):4463-70
18662303
Clin Ther. 2009 Nov;31(11):2618-27
20110006
Life Sci. 2007 May 1;80(21):1957-65
17379255
J Int Med Res. 2003 Mar-Apr;31(2):88-101
12760312
Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9
16797629
J Assoc Physicians India. 1994 Oct;42(10):775-6
7876045
Evid Based Complement Alternat Med. 2005 Sep;2(3):301-8
16136208
Mutat Res. 2010 Aug 7;690(1-2):139-44
20067801
Arch Biochem Biophys. 2000 Apr 15;376(2):338-46
10775421
J Appl Toxicol. 2007 Sep-Oct;27(5):472-81
17299831
Phytomedicine. 2010 Jan;17(1):3-13
19959000
Arthritis Rheum. 2009 May;60(5):1282-93
19404960
Free Radic Biol Med. 2008 Mar 15;44(6):1032-41
18206666
Br J Pharmacol. 2009 Dec;158(7):1705-12
19912233
Biosci Biotechnol Biochem. 2000 Oct;64(10):2218-20
11129598
Arthritis Rheum. 2006 Aug;54(8):2393-401
16869002
Arthritis Rheum. 2008 Oct;58(10):3145-56
18821707
Eur J Clin Nutr. 1996 Jan;50(1):28-32
8617188
J Allergy Clin Immunol. 2004 Jun;113(6):1211-7
15208607
Arthritis Res Ther. 2009;11(3):R71
19445683
J Biol Chem. 1993 Feb 5;268(4):2513-24
8428929
Matrix Biol. 2004 Jun;23(3):163-9
15296944
Rheumatol Int. 2010 Jul;30(9):1197-203
19777241
Br J Rheumatol. 1993 Jul;32(7):562-7
8393361
Curr Med Chem. 2009;16(19):2395-415
19601788
Mol Pharmacol. 2010 Jan;77(1):17-25
19828731
Front Biosci. 2006 Sep 01;11:3081-95
16720377
Free Radic Biol Med. 2009 Sep 1;47(5):636-43
19501156
Gut. 2003 Jan;52(1):144-51
12477778
Arthritis Rheum. 1996 Apr;39(4):648-56
8630116
Arch Biochem Biophys. 2002 Jan 15;397(2):424-9
11795903
Int Arch Allergy Immunol. 2007;142(4):335-44
17135765
Arthritis Rheum. 2000 Nov;43(11):2501-12
11083274
Rheumatology (Oxford). 2010 Mar;49(3):467-79
20032224
Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(22):2678-82
19216171
J Pharmacol Exp Ther. 2005 Dec;315(3):1172-80
16123309
Nat Struct Mol Biol. 2004 Apr;11(4):380-1
15024383
Science. 2002 Dec 6;298(5600):1911-2
12471242
Fen Zi Xi Bao Sheng Wu Xue Bao. 2009 Jun;42(3-4):179-85
19697699
Toxicol Appl Pharmacol. 2001 Oct 15;176(2):110-7
11601887
J Am Coll Nutr. 2006 Apr;25(2):79-99
16582024
Lancet. 2001 Sep 15;358(9285):903-11
11567728
Arthritis Rheum. 2002 Aug;46(8):2079-86
12209512
Phytomedicine. 2010 Jan;17(1):14-8
19819682
Eur J Biochem. 2003 Jun;270(11):2394-403
12755694
J Nutr Sci Vitaminol (Tokyo). 1997 Dec;43(6):679-84
9530620
J Agric Food Chem. 2003 Jul 16;51(15):4427-35
12848521
J Nutr. 2004 May;134(5):1039-44
15113942
J Nutr. 2003 Oct;133(10):3275S-84S
14519826
J Rheumatol. 1988 Apr;15(4):670-7
3397978
Chem Biol Interact. 2007 Apr 25;167(2):85-98
17368440
Biochem Pharmacol. 1997 Dec 15;54(12):1281-6
9393670
J Biol Chem. 1996 Jun 28;271(26):15703-7
8663189
Free Radic Biol Med. 2007 Aug 15;43(4):546-56
17640565
Am J Manag Care. 2009 Sep;15(8 Suppl):S236-43
19817510
Curr Opin Pharmacol. 2004 Aug;4(4):423-8
15251139
Mol Nutr Food Res. 2009 Jun;53(6):716-25
19437482
Proc Soc Exp Biol Med. 1999 Apr;220(4):203-9
10202389
J Immunol. 2004 Nov 1;173(9):5794-800
15494532
Best Pract Res Clin Rheumatol. 2006 Feb;20(1):3-25
16483904
Curr Rheumatol Rev. 2008 Nov 1;4(4):246
20165551
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4524-9
10200295
Arthritis Rheum. 2002 Dec;46(12):3143-50
12483717
Nat Rev Drug Discov. 2004 Apr;3(4):330-9
15060528
Food Chem Toxicol. 2008 Apr;46(4):1298-307
18226437
Inflamm Res. 2008 Jul;57(7):306-13
18545934
Curr Opin Rheumatol. 2006 Jul;18(4):419-26
16763464
Arthritis Rheum. 2002 Dec;46(12):3151-8
12483718
J Invest Dermatol. 2008 Oct;128(10):2429-41
18463684
Nat Rev Genet. 2003 Aug;4(8):638-49
12897775
Free Radic Res. 1999 May;30(5):395-405
10342332
Clin Rheumatol. 2010 Jun;29(6):619-24
20101426
Rheumatol Int. 2008 Nov;29(1):23-9
18496696
Scand J Rheumatol. 2010 Mar;39(2):132-40
20059371
Arthritis Res Ther. 2007;9(5):220
18001488
Immunology. 2003 Jul;109(3):415-25
12807488
Mutat Res. 2003 Feb-Mar;523-524:119-25
12628509
Semin Arthritis Rheum. 1996 Feb;25(4):254-72
8834014
Food Chem Toxicol. 2002 Dec;40(12):1745-50
12419687
Cells Tissues Organs. 2003;174(1-2):34-48
12784040
Inflamm Res. 2001 Sep;50(9):435-41
11603847
Biol Pharm Bull. 2004 Sep;27(9):1353-8
15340218
Arch Biochem Biophys. 2002 Jan 1;397(1):84-90
11747313
Arch Biochem Biophys. 2003 Jul 1;415(1):126-32
12801521
Talanta. 2002 May 16;57(2):307-16
18968631
Free Radic Biol Med. 2009 Oct 1;47(7):1028-38
19607912
Clin Microbiol Infect. 2009 Apr;15(4):341-6
19431221
Brain Behav Immun. 2009 Aug;23(6):721-31
19258034
J Med Chem. 2009 Aug 13;52(15):4757-73
19606871
Nat Clin Pract Rheumatol. 2005 Nov;1(1):31-9
16932625
Free Radic Res. 1998 Oct;29(4):351-8
9860050
Curr Opin Clin Nutr Metab Care. 2000 May;3(3):205-11
10871236
Biochem Biophys Res Commun. 2009 Feb 20;379(4):1033-7
19150340
J Biol Chem. 2007 Mar 23;282(12):8632-40
17255106
Annu Rev Immunol. 2001;19:163-96
11244034
Cancer Res. 1999 Sep 15;59(18):4610-7
10493515
J Nutr Biochem. 2010 Jul;21(7):659-64
19616927
Arthritis Rheum. 2008 Jan;58(1):26-35
18163497
Curr Drug Targets. 2007 Feb;8(2):305-13
17305508
Biorheology. 2002;39(1-2):119-24
12082274
Free Radic Biol Med. 1996;21(6):895-902
8902534
J Am Coll Nutr. 2002 Feb;21(1):1-13
11838881
FASEB J. 2004 Oct;18(13):1621-3
15319365
Ann N Y Acad Sci. 2002 Nov;973:435-7
12485906
Anal Sci. 2002 Mar;18(3):313-8
11918191
Arthritis Rheum. 2009 Jul;60(7):1957-65
19565503
Cancer Lett. 2008 Oct 8;269(2):269-80
18501505
Clin Chim Acta. 2003 Dec;338(1-2):123-9
14637276
Biol Pharm Bull. 2006 Jun;29(6):1120-5
16755003
Gastroenterology. 2008 Jun;134(7):1972-80
18549879
Shock. 2000 May;13(5):346-60
10807009
Biosci Rep. 2008 Feb;28(1):33-48
18269348
Biochem Biophys Res Commun. 2009 Oct 16;388(2):350-4
19665000
Biorheology. 2000;37(1-2):109-16
10912183
Ann Rheum Dis. 1992 Nov;51(11):1219-22
1466599
J Immunol. 2003 Apr 15;170(8):4335-41
12682270
Annu Rev Immunol. 2000;18:621-63
10837071
Nat Clin Pract Rheumatol. 2009 Mar;5(3):128-9
19252516
Proteomics. 2006 Feb;6(4):1351-61
16404724
J Rheumatol. 2010 Jan;37(1):167-74
19884267
Cell Physiol Biochem. 2009;24(5-6):503-10
19910690
J Cell Biol. 1997 Oct 20;139(2):541-52
9334355
Mol Pharmacol. 2001 Sep;60(3):528-33
11502884
Arthritis Rheum. 2008 Jan;58(1):15-25
18163481
Ann Rheum Dis. 2004 Mar;63(3):233-9
14962955
Life Sci. 2008 May 7;82(19-20):1012-7
18407296
Ann Rheum Dis. 2003 Nov;62 Suppl 2:ii43-7
14532148
FASEB J. 2001 May;15(7):1309-11
11344123
Am Fam Physician. 2009 Apr 1;79(7):591-4
19378876
Acta Orthop Scand. 2003 Apr;74(2):190-5
12807328
Ann Rheum Dis. 2010 Jan;69(1):270-5
19279017
J Rheumatol. 2005 Oct;32(10):1958-67
16206353
J Nutr. 1998 Dec;128(12):2334-40
9868178
Springer Semin Immunopathol. 2006 Jun;27(4):391-408
16738952
Arthritis Rheum. 2008 Jul;58(7):2012-8
18576345
Phytochemistry. 2000 Feb;53(3):391-4
10703063
Osteoarthritis Cartilage. 1999 Sep;7(5):439-40
10489315
Horm Metab Res. 2008 Oct;40(10):674-8
18500674
J Pharmacol Exp Ther. 2004 Feb;308(2):767-73
14600251
Arthritis Rheum. 2006 May;54(5):1662-72
16646038
Osteoarthritis Cartilage. 1998 Mar;6(2):146-9
9692069
J Cell Biochem. 2007 Apr 1;100(5):1146-53
17031857
Prev Med. 1994 May;23(3):377-84
8078860
Arthritis Rheum. 2004 Jun;50(6):2014-23
15188379
J Orthop Res. 2003 Jan;21(1):102-9
12507586
Int J Pharm. 2010 Apr 15;389(1-2):207-12
20083179