The assessment of subclinic atherosclerosis objected through IMT in normal and dyslipidemic patients with various degrees of glucose tolerance.
OBJECTIVE
The evaluation of atherosclerosis, by the measurement of intima media thickness (IMT) at the level of right common carotid arteries (CCA Right) and left (CCA Left), for normolipidemic patients (NL) and dislipidemic patients (DLP) with various degrees of alteration to glucose tolerance. DESIGN AND METHODS OF RESEARCH: We have analyzed a group of 120 NL patients and a group of 120 DLP patients. The test of orally provoked hyperglycemia was performed to assess the disturbance of tolerance to glucose. IMT was determined by the method of ultrasonography in model 2B at the level of right and left common carotid arteries, measured at 2 cm from the bifurcation of common carotids.


RESULTS
For patients with DLP the IMT medium was statistically higher than the group of NL patients. The normoglycemic normolipidemic patients (NGNL) presented a lower IMT value than the normoglycemic dislipidemic patients (NGDLP). For the group of DLP patients, IMT was statistically higher for patients with pre-diabetes (ALT)--impaired fasting glycaemia (IFG) and the impaired glucose tolerance (IGT)--compared to NG patients (with statistical signification).


CONCLUSIONS
The presence of sub-clinic atherosclerosis objected through IMT was higher for DLP patients compared to NL patients demonstrating the role of dyslipidemia in the production of atherosclerosis. For patients with diabetes (DM), of both groups, the value of IMT was higher as compared to NG patients, demonstrating the influence of hyperglycemia in the production of atherosclerosis.
Braicu
Marioara Daniela
MD
Clinical Centre of Diabetes, Nutrition & Metabolic Diseases, SCF Hospital, Craiova, Romania.
Priţulescu
Cristina
C
Alexandru
D
D
Moţa
Maria
M
D002340:Carotid Artery Diseases / Q000453:epidemiology*; D017536:Carotid Artery, Common / Q000473:pathology; D002343:Carotid Artery, Internal / Q000473:pathology; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D050171:Dyslipidemias / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged