title: Fundamental frequency and regularity of cardiac electrograms with Fourier organization analysis.
abstract: Dominant frequency analysis (DFA) and organization analysis (OA) of cardiac electrograms (EGMs) aims to establish clinical targets for cardiac arrhythmia ablation. However, these previous spectral descriptions of the EGM have often discarded relevant information in the spectrum, such as the harmonic structure or the spectral envelope. We propose a fully automated algorithm for estimating the spectral features in EGM recordings. This approach, called Fourier OA (FOA), accounts jointly for the organization and periodicity in the EGM, in terms of the fundamental frequency instead of dominant frequency. In order to compare the performance of FOA and DFA-OA approaches, we analyzed simulated EGM, obtained in a computer model, as well as two databases of implantable defibrillator-stored EGM. FOA parameters improved the organization measurements with respect to OA, and averaged cycle length and regularity indexes were more accurate when related to the fundamental (instead of dominant) frequency, as estimated by the algorithm (p < 0.05 comparing f(0) estimated by DFA and by FOA). FOA yields a more detailed and robust spectral description of EGM compared to DFA and OA parameters.
authors.affiliation: Department of Signal Theory and Communications, University Rey Juan Carlos, Fuenlabrada, Madrid 28943, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Barquero-Pérez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Rojo-Alvarez
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Caamaño
authors.forename: Rebeca
authors.initials: R
authors.lastname: Goya-Esteban
authors.forename: Estrella
authors.initials: E
authors.lastname: Everss
authors.forename: Felipe
authors.initials: F
authors.lastname: Alonso-Atienza
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Sánchez-Muñoz
authors.forename: Arcadi
authors.initials: A
authors.lastname: García-Alberola
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D016208:Databases, Factual; D004562:Electrocardiography / Q000379:methods*; D005583:Fourier Analysis; D006801:Humans; D010363:Pattern Recognition, Automated / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D014693:Ventricular Fibrillation / Q000503:physiopathology*