title: Immunotoxicity activity of the major essential oils of Valeriana fauriei Briq against Aedes aegypti L.
abstract: The rhizomes and roots of Valeriana fauriei were extracted and the major essential oil composition and immunotoxicity effects were studied. The analyses were conducted by gas chromatography-mass spectroscopy (GC-MS) revealed that the essential oils of V. fauriei. The V. fauriei essential oil (VFEO) yield was 1.93%, and GC/MS analysis revealed that its major constituents were bornyl acetate (32.83%), terpinyl acetate (3.82%), bornyl isovalerate (2.11%), β-sesquiphellandrene (2.21%), sesquiterpene alcohol (7.32%), and cedrol (2.45%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 30.44 ppm and an LC(90) value of 82.64 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against Aedes aegypti L.
authors.affiliation: Department of Applied Life science, Kon Kuk University, Seoul, South Korea.
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Kim
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000330:Aedes / Q000187:drug effects / Q000254:growth & development*; D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D007928:Lethal Dose 50; D009032:Mosquito Control / Q000379:methods; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D014632:Valerian / Q000737:chemistry*
chemical_list: D007306:Insecticides; D009822:Oils, Volatile