title: Consecutive appearance of corneal subepithelial infiltrates after intravitreous bevacizumab injections.
abstract: OBJECTIVE
  To report a case of corneal subepithelial infiltrates appearing after intravitreous bevacizumab injections.
  
  
  METHODS
  A review of the patient's history and clinical examination findings in a patient who had epidemic keratoconjunctivitis more then 20 years before treatment with bevacizumab for age-related macular degeneration.
  
  
  RESULTS
  After the third and fourth bevacizumab injections, the patient presented with unilateral corneal subepithelial infiltrates. The infiltrates were accompanied by mild anterior chamber reaction and resolved with topical steroid treatment.
  
  
  CONCLUSIONS
  Treatment with intravitreous bevacizumab may precipitate an immune response leading to the appearance of corneal subepithelial infiltrates.
authors.affiliation: Rabin Medical Center, Campus Belinson, Petach Tikva, Israel. danb2@clalit.org.il
authors.forename: Dan H
authors.initials: DH
authors.lastname: Bourla
authors.forename: Assaf
authors.initials: A
authors.lastname: Dotan
authors.forename: Dov
authors.initials: D
authors.lastname: Weinberger
authors.forename: Nirit
authors.initials: N
authors.lastname: Bourla
authors.forename: Israel
authors.initials: I
authors.lastname: Kremer
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D019573:Epithelium, Corneal; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007267:Injections; D008268:Macular Degeneration / Q000188:drug therapy; D012008:Recurrence; D019233:Retreatment; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014822:Vitreous Body
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab