title: [Bilateral deafness and unilateral facial nerve palsy as presenting features of Wegener's granulomatosis : a case report].
abstract: A 72-year-old female patient presented with otitis of her left ear with inner ear depletion. Despite administration of intravenous antibiotics according to the resistogram and mastoidectomy the patient developed a similar pathological condition in the right ear and facial nerve palsy on the left side. Treatment with trimethoprim/sulfamethoxazole under the working diagnosis of a localised seronegative Wegener's granulomatosis was initiated without achieving remission. Cyclophosphamide pulse therapy in combination with high-dose methylprednisolone was initiated with rapid cure of the bilateral otitis. Sensorineural hearing loss and facial nerve palsy remained irreversible.
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Lessingstr. 2, 07743, Jena, Deutschland. silvia.bohne@med.uni-jena.de
authors.forename: S
authors.initials: S
authors.lastname: Bohne
authors.forename: S
authors.initials: S
authors.lastname: Koscielny
authors.forename: H P
authors.initials: HP
authors.lastname: Burmeister
authors.forename: O
authors.initials: O
authors.lastname: Guntinas-Lichius
authors.forename: C
authors.initials: C
authors.lastname: Wittekindt
mesh_terms: D000368:Aged; D020330:Bell Palsy / Q000175:diagnosis* / Q000209:etiology*; D003638:Deafness / Q000175:diagnosis* / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis*; D006801:Humans
references.citation: Curr Opin Rheumatol. 2001 Jan;13(1):48-55
references.pmid: 11148715
references.citation: Arthritis Rheum. 1994 Feb;37(2):187-92
references.pmid: 8129773
references.citation: Ann Intern Med. 1989 Jul 1;111(1):28-40
references.pmid: 2660645
references.citation: Am J Med. 2003 Apr 15;114(6):463-9
references.pmid: 12727579
references.citation: Rheumatology (Oxford). 2002 May;41(5):589-90
references.pmid: 12011388
references.citation: Curr Opin Rheumatol. 2000 Jan;12(1):32-40
references.pmid: 10647952
references.citation: Curr Opin Rheumatol. 2001 Jan;13(1):3-11
references.pmid: 11148709
references.citation: Auris Nasus Larynx. 2007 Sep;34(3):379-82
references.pmid: 17350198
references.citation: Ann Intern Med. 1992 Mar 15;116(6):488-98
references.pmid: 1739240
references.citation: Otol Neurotol. 2004 Sep;25(5):833-7
references.pmid: 15354019
references.citation: Clin Otolaryngol Allied Sci. 1989 Oct;14(5):451-6
references.pmid: 2582643
references.citation: Arthritis Rheum. 1990 Aug;33(8):1101-7
references.pmid: 2202308
references.citation: Auris Nasus Larynx. 2009 Feb;36(1):64-70
references.pmid: 18479857
references.citation: Laryngoscope. 2002 Sep;112(9):1684-90
references.pmid: 12352687
references.citation: Q J Med. 1992 Jun;83(302):427-38
references.pmid: 1448544