title: Trifluoromethyl nitrones: from fluoral to optically active hydroxylamines.
abstract: Trifluoromethyl nitrones were obtained in high yields by condensation of various hydroxylamines with trifluoroacetaldehyde hydrate. The nucleophilic diastereoselective additions of organometallic reagents to these nitrones afforded the corresponding optically active trifluoroethyl hydroxylamines in good yields.
authors.affiliation: Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ. Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Milcent
authors.forename: Nathan
authors.initials: N
authors.lastname: Hinks
authors.forename: Danièle
authors.initials: D
authors.lastname: Bonnet-Delpon
authors.forename: Benoit
authors.initials: B
authors.lastname: Crousse
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D019811:Hydroxylamine / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D055620:Optical Phenomena; D013237:Stereoisomerism
chemical_list: D005617:Chlorofluorocarbons, Methane; D009589:Nitrogen Oxides; C015388:nitrones; D019811:Hydroxylamine; C019120:trifluoroacetaldehyde hydrate; D000079:Acetaldehyde; C009554:fluoroform