title: Comparison of left ventricular contractility in pressure and volume overload: a strain rate study in the clinical model of aortic stenosis and regurgitation.
abstract: OBJECTIVE
  The aim of this study is to compare the impact of two different loading conditions on myocardial contractility in asymptomatic patients with normal EF by using stain rate imaging (SRI).
  
  
  METHODS
  A total of 27 patients with severe aortic regurgitation (mean age 50 ± 11 years) and 25 patients with severe aortic stenosis (mean age 53 ± 15 years) were prospectively recruited. Fifteen healthy subjects (mean age 50 ± 6 years) were enrolled as the control group. For the evaluation myocardial contractility, longitudinal LV function was chosen and, midventricular segment shortening was analyzed for the septum, LV lateral wall from apical four-chamber view and for the anterior, inferior wall from apical two-chamber view.
  
  
  RESULTS
  Longitudinal peak systolic strain rate values of each segment derived from analysis of a total of 804 segments were significantly decreased in the patients population (P < 0.001). Global longitudinal peak systolic strain rate was also significantly decreased in aortic stenosis and regurgitation compared to the control group (-1 ± 0.5, -0.9 ± 0.3, and -1.6 ± 0.3, P = 0.001). As far as the comparison between patients with aortic stenosis and aortic regurgitation, neither global strain rate nor strain rate for each wall was found to be different.
  
  
  CONCLUSIONS
  We conclude that longitudinal LV function is reduced in both pressure and volume overload, and both of this overload patterns are equally harmful to the ventricle.
authors.affiliation: Acibadem University Kocaeli Hospital, Cardiology Department, Izmit, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Gorgulu
authors.forename: Tugrul
authors.initials: T
authors.lastname: Norgaz
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Nurkalem
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ergelen
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Eksik
authors.forename: Ahmet
authors.initials: A
authors.lastname: Genc
authors.forename: Aycan E
authors.initials: AE
authors.lastname: Zencirci
mesh_terms: D001022:Aortic Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001794:Blood Pressure; D004452:Echocardiography / Q000379:methods; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*