title: Models of dynamic extraction of lipid tethers from cell membranes.
abstract: When a ligand that is bound to an integral membrane receptor is pulled, the membrane and the underlying cytoskeleton can deform before either the membrane delaminates from the cytoskeleton or the ligand detaches from the receptor. If the membrane delaminates from the cytoskeleton, it may be further extruded and form a membrane tether. We develop a phenomenological model for this process by assuming that deformations obey Hooke's law up to a critical force at which the cell membrane locally detaches from the cytoskeleton and a membrane tether forms. We compute the probability of tether formation and show that tethers can be extruded only within an intermediate range of force loading rates and pulling velocities. The mean tether length that arises at the moment of ligand detachment is computed as are the force loading rates and pulling velocities that yield the longest tethers.
authors.affiliation: RAND Corporation, Los Angeles, CA 90405, USA.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Nowak
authors.forename: Tom
authors.initials: T
authors.lastname: Chou
mesh_terms: D001696:Biomechanical Phenomena; D002462:Cell Membrane / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008954:Models, Biological; D013314:Stress, Mechanical
chemical_list: D008563:Membrane Lipids