title: Protective effect of Artemisia afra Jacq. on isoproterenol-induced myocardial injury in Wistar rats.
abstract: Artemisiaafra Jacq. ex Willd. is a widely used medicinal plant in South Africa for the treatment of various diseases. In this study, the effect of the herb on isoproterenol (ISO)-induced myocardial injury in rats was investigated. Pretreatment with the aqueous leaf extract of the plant at 100 and 200 mg/kg body weight for 30 days prevented the elevation of serum marker enzymes namely lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) in myocardial injured rats. ISO-induced animals exhibited decreased levels of glutathione reductase (GR), glutathione peroxides (GPx), superoxide dismutase (SOD) and glutathione (GSH) in the heart, which were restored to near normal levels following treatment with the herb. The extract also attenuated lipid peroxidation (LPO) in the heart and improved the imbalance in lipid profile caused by ISO. The effect was more prominent at 200 mg/kg body weight. These findings revealed the cardioprotective effect of A. afra against isoproterenol-induced myocardial injury.
authors.affiliation: Phytomedicine Research Center, Department of Botany, University of Fort Hare, Alice 5700, South Africa.
authors.forename: T O
authors.initials: TO
authors.lastname: Sunmonu
authors.forename: A J
authors.initials: AJ
authors.lastname: Afolayan
mesh_terms: D000318:Adrenergic beta-Agonists / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D019306:Artemisia / Q000737:chemistry*; D004798:Enzymes / Q000378:metabolism; D006331:Heart Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D007545:Isoproterenol / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000318:Adrenergic beta-Agonists; D000975:Antioxidants; D004798:Enzymes; D010936:Plant Extracts; D020011:Protective Agents; D007545:Isoproterenol