title: A case of explosive progression of hepatocellular carcinoma in a patient with common variable immunodeficiency (CVID).
abstract: OBJECTIVE
  While it is well known that patients with common variable immunodeficiency (CVID) are predisposed to various malignancies, primarily non-Hodgkin's lymphoma and gastric carcinomas, to our knowledge no cases of hepatocellular carcinoma have been reported in the absence of preexisting liver disease.
  
  
  RESULTS
  We report a 50-year-old male patient with CVID with a B- and T-cell deficiency. The patient was on prophylactic intravenous gammaglobulin and had received several years earlier a course of rituximab for an autoimmune disorder. He had no history of hepatitis. The patient developed a rapidly progressing hepatocellular carcinoma within 3 to 4 weeks.
  
  
  CONCLUSIONS
  Although patients with CVID are predisposed to malignancies such as lymphoma and adenocarcinoma of the stomach, rapidly progressive hepatocellular carcinoma in the absence of any preexisting liver disease has not been described.
authors.affiliation: Department of Internal Medicine, Westchester Medical Center/New York Medical College, New York, USA. kaushanggandhi@yahoo.com
authors.forename: Kaushang
authors.initials: K
authors.lastname: Gandhi
authors.forename: Purvi
authors.initials: P
authors.lastname: Parikh
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.forename: Harit
authors.initials: H
authors.lastname: Desai
authors.forename: Harshad
authors.initials: H
authors.lastname: Amin
authors.forename: Mala
authors.initials: M
authors.lastname: Sharma
authors.forename: Arye
authors.initials: A
authors.lastname: Rubinstein
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D007155:Immunologic Factors
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