Evaluation of platelet activation, coagulation, and fibrinolytic activation in patients with symptomatic lacunar stroke.
BACKGROUND
It is unclear whether hemostasis plays a role in the pathogenesis of ischemic stroke subtypes.


OBJECTIVE
We aimed to investigate the possible relationship between different hemostatic markers and lacunar stroke.


RESULTS
The study consisted of 30 patients with symptomatic lacunar stroke and 30 healthy age-matched healthy individuals. We analyzed the values of "Mean Platelet Volume," D-dimer, "soluble p-selectin," "Plasminogen Activator Inhibitor Type-1" (PAI-1), "Thrombin-Activatable Fibrinolysis Inhibitor" (TAFI), and "Platelet Factor 4" (PF4) in patients with lacunar infarct and compared these values to those of control individuals. There were significant differences for D-dimer, mean platelet volume, thrombin-activatable fibrinolysis inhibitor, and platelet factor 4 values in symptomatic lacunar stroke group compared with the control group (P < 0.01).


CONCLUSIONS
Different hemostatic factors may play a role in the pathogenesis of lacunar stroke. Evaluating the role of hemostatic factors on different types of strokes may help us identify new therapeutic strategies and different prognostic stratifications for ischemic stroke.
Ilhan
Demet
D
Department of Neurology and Internal Medicine, Dumlupinar University, School of Medicine, Kutahya, Turkey.
Ozbabalik
Demet
D
Gulcan
Erim
E
Ozdemir
Ozcan
O
Gülbaçs
Zafer
Z
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000175:diagnosis; D020520:Brain Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D025901:Carboxypeptidase B2 / Q000032:analysis / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000378:metabolism; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis / Q000097:blood; D015539:Platelet Activation / Q000502:physiology; D010978:Platelet Factor 4 / Q000032:analysis / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; C036309:fibrin fragment D; D010978:Platelet Factor 4; D025901:Carboxypeptidase B2