Upper gastrointestinal carcinogenesis: H. pylori and stem cell cross-talk.
Chronic inflammation of the gastric epithelium has been associated with the pathogenesis of gastric cancer, as it was postulated by Corea's model of gastric carcinogenesis. Helicobacter pylori (Hp) regulates this inflammatory process and promotes gastric carcinogenesis through induction of gene mutations and protein modulation. Recent data raise the cancer stem cell hypothesis, which implies a central role of multipotent cancer cells in oncogenesis of various solid tumors. This review provides a synopsis of gastric cancer initiation and promotion through Hp and stem cell signaling pathways. The expanding research field of Hp-related cancer stem cell biology may offer novel implications for future treatment of upper gastrointestinal cancer.
Pilpilidis
Ioannis
I
Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.
Kountouras
Jannis
J
Zavos
Christos
C
Katsinelos
Panagiotis
P
D001854:Bone Marrow Cells / Q000473:pathology; D002450:Cell Communication / Q000502:physiology; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D012307:Risk Factors; D015398:Signal Transduction / Q000502:physiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*