title: Human effector/initiator gene sets that regulate myometrial contractility during term and preterm labor.
abstract: OBJECTIVE
  Distinct processes govern transition from quiescence to activation during term (TL) and preterm labor (PTL). We sought gene sets that are responsible for TL and PTL, along with the effector genes that are necessary for labor independent of gestation and underlying trigger.
  
  
  METHODS
  Expression was analyzed in term and preterm with or without labor (n=6 subjects/group). Gene sets were generated with logic operations.
  
  
  RESULTS
  Thirty-four genes were expressed similarly in PTL/TL but were absent from nonlabor samples (effector set); 49 genes were specific to PTL (preterm initiator set), and 174 genes were specific to TL (term initiator set). The gene ontogeny processes that comprise term initiator and effector sets were diverse, although inflammation was represented in 4 of the top 10; inflammation dominated the preterm initiator set.
  
  
  CONCLUSIONS
  TL and PTL differ dramatically in initiator profiles. Although inflammation is part of the term initiator and the effector sets, it is an overwhelming part of PTL that is associated with intraamniotic inflammation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, KS 66160, USA. cweiner@kumc.edu
authors.forename: Carl P
authors.initials: CP
authors.lastname: Weiner
authors.forename: Clifford W
authors.initials: CW
authors.lastname: Mason
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Dong
authors.forename: Irina A
authors.initials: IA
authors.lastname: Buhimschi
authors.forename: Peter W
authors.initials: PW
authors.lastname: Swaan
authors.forename: Catalin S
authors.initials: CS
authors.lastname: Buhimschi
mesh_terms: D000328:Adult; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007249:Inflammation / Q000235:genetics; D007743:Labor, Obstetric / Q000235:genetics*; D007752:Obstetric Labor, Premature / Q000235:genetics* / Q000503:physiopathology; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D047929:Term Birth / Q000235:genetics*; D014590:Uterine Contraction / Q000235:genetics*; D055815:Young Adult
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