title: Surface-enhanced Raman scattering biomedical applications of plasmonic colloidal particles.
abstract: This review article presents a general view of the recent progress in the fast developing area of surface-enhanced Raman scattering spectroscopy as an analytical tool for the detection and identification of molecular species in very small concentrations, with a particular focus on potential applications in the biomedical area. We start with a brief overview of the relevant concepts related to the choice of plasmonic nanostructures for the design of suitable substrates, their implementation into more complex materials that allow generalization of the method and detection of a wide variety of (bio)molecules and the strategies that can be used for both direct and indirect sensing. In relation to indirect sensing, we devote the final section to a description of SERS-encoded particles, which have found wide application in biomedicine (among other fields), since they are expected to face challenges such as multiplexing and high-throughput screening.
authors.affiliation: Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Abalde-Cela
authors.forename: Paula
authors.initials: P
authors.lastname: Aldeanueva-Potel
authors.forename: Cintia
authors.initials: C
authors.lastname: Mateo-Mateo
authors.forename: Laura
authors.initials: L
authors.lastname: Rodríguez-Lorenzo
authors.forename: Ramón A
authors.initials: RA
authors.lastname: Alvarez-Puebla
authors.forename: Luis M
authors.initials: LM
authors.lastname: Liz-Marzán
mesh_terms: D024803:Biomedical Enhancement / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
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