Neutralising antibody responses in cattle and sheep following booster vaccination with two commercial inactivated bluetongue virus serotype 8 vaccines.
Cattle and sheep that had received a primary course of vaccination with an inactivated bluetongue virus serotype 8 (BTV-8) vaccine were booster vaccinated 6 or 12 months later with the homologous vaccine or an alternative inactivated BTV-8 vaccine and neutralising antibody responses were determined. Antibody titres to the alternative vaccine were significantly higher than to the homologous vaccine (P=0.013) in cattle. There was no significant difference between the antibody responses to alternative and homologous vaccines in sheep. These data indicate that cattle and sheep primed with one inactivated BTV-8 vaccine may be effectively boosted with an alternative commercial inactivated BTV-8 vaccine.
Bartram
David J
DJ
Fort Dodge Animal Health, Hedge End, Southampton SO30 4QH, UK. david.bartram@pfizer.com
Heasman
Lindsay
L
Batten
Carrie A
CA
Oura
Christopher A L
CA
Plana-Durán
Joan
J
Yuen
Ho Ming
HM
Wylie
Andrew D M
AD
D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood* / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D001819:Bluetongue / Q000276:immunology / Q000517:prevention & control*; D001820:Bluetongue virus / Q000276:immunology*; D002417:Cattle; D005260:Female; D007117:Immunization, Secondary / Q000662:veterinary*; D008297:Male; D012756:Sheep; D015164:Vaccines, Inactivated; D014765:Viral Vaccines / Q000276:immunology*
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines