Development of aggressive squamous cell carcinoma in epidermodysplasia verruciformis associated with human papillomavirus type 22b.
Epidermodysplasia verruciformis (EV) is a rare genetic disease characterized by abnormal susceptibility to infection with EV-related human papillomavirus (HPV), now known as the beta-papillomavirus (beta-PV). Clinically specific beta-PV-type-associated EV, especially HPV-5 and -8, shows a high rate of progression to squamous cell carcinoma (SCC). In this report, we describe a 39-year-old Korean man with HPV-22b-associated EV who developed a rapidly progressing SCC. The patient presented with a huge destructive mass on the nose. Histopathological evaluation of the mass was compatible with well-differentiated SCC. HPV typing results from both EV and SCC specimens demonstrated HPV-22b which has not been considered to be associated with SCC in EV patients so far. The patient underwent surgical excision and postoperative radiotherapy for locoregional control. This is the first report presenting the association of an SCC arising from previous EV with HPV-22b infection only.
Kim
Taegyun
T
Department of Dermatology and Cutaneous Biology Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sinchon-Dong, Seodaemoon-Gu, Seoul, Korea.
Park
Jae Chan
JC
Roh
Mi Ryung
MR
Park
Jin Mo
JM
Kim
Se Heon
SH
Cho
Nam Hoon
NH
Lee
Min-Geol
MG
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy / Q000821:virology*; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy / Q000821:virology*