Estimating changes in cardiac output using an implanted hemodynamic monitor in heart failure patients.
OBJECTIVE
The aim of this study was to evaluate an algorithm that estimates changes in cardiac output (CO) from right ventricular (RV) pressure waveforms derived from an implantable hemodynamic monitor (IHM) in heart failure patients.


METHODS
Twelve heart failure patients (NYHA II-III, EF 32%) with an implantable hemodynamic monitor (Chronicle) were included in this study. Changes in cardiac output were provoked by body position change at rest (left lateral supine, horizontal supine, sitting, and standing) and a steady state bicycle exercise at 20 watts. Estimated CO derived from the IHM (CO(IHM)) was compared to CO measured with inert gas rebreathing (CO(RB)), echocardiography (CO(ECHO)) and impedance cardiography (CO(ICG)). CO(RB) was considered the reference method.


RESULTS
The median intra-patient correlation coefficient comparing CO(RB) and CO(IHM) was 0.83 (range: 0.63-0.98). Comparing CO(RB) with CO(ECHO) and CO(ICG) resulted in mean intra-patient correlation coefficients of 0.73 (-0.29-0.94) and 0.63 (-0.29-0.96). In a statistical model where slope and intercept was considered random between patients the coefficient of determination (R2) comparing CO(RB) and CO(IHM) was 0.91. Mean bias was -0.39 L/min (11%). Limits of agreement were +/-1.56 L/min and relative error was 21%.


CONCLUSIONS
A simple algorithm based on RV pressure wave form characteristics derived from an IHM can be used to estimate changes in CO in heart failure patients. These findings encourage further research aiming to improve and validate the algorithm.
Ståhlberg
Marcus
M
Karolinska Institutet, Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden. marcus.stahlberg@ki.se
Damgaard
Morten
M
Ersgård
David
D
Norsk
Peter
P
Karamanoglu
Mustafa
M
Linde
Cecilia
C
Braunschweig
Frieder
F
D000368:Aged; D000465:Algorithms; D002302:Cardiac Output; D002307:Cardiography, Impedance; D004452:Echocardiography; D004567:Electrodes, Implanted; D004867:Equipment Design; D015444:Exercise; D006333:Heart Failure / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D011187:Posture; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D014160:Transducers, Pressure; D016278:Ventricular Function, Right; D017725:Ventricular Pressure