HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients.
The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.
Skar
Helena
H
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobels vag 16, 17177 Stockholm, Sweden. helena.skar@smi.se
Borrego
Pedro
P
Wallstrom
Timothy C
TC
Mild
Mattias
M
Marcelino
José Maria
JM
Barroso
Helena
H
Taveira
Nuno
N
Leitner
Thomas
T
Albert
Jan
J
D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D015658:HIV Infections / Q000235:genetics / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity; D015498:HIV-2 / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D012641:Selection, Genetic; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics
D004279:DNA, Viral; D054299:env Gene Products, Human Immunodeficiency Virus
J Virol. 1996 Dec;70(12):8285-300
8970948
J Virol. 2004 Feb;78(4):1962-70
14747561
Eur J Immunol. 2008 Feb;38(2):350-63
18200635
J Immunol. 2006 Jun 1;176(11):6973-81
16709858
J Virol. 2009 Nov;83(22):11966-78
19740980
PLoS Comput Biol. 2007 Feb 16;3(2):e29
17305421
J Virol. 1999 Dec;73(12):10489-502
10559367
J Virol. 1990 Oct;64(10):5177-82
1975844
J Infect Dis. 2007 Mar 1;195(5):726-33
17262716
J Infect Dis. 2000 Jan;181(1):64-75
10608752
Cell. 2006 Jun 16;125(6):1055-67
16777597
Arch Intern Med. 2000 Nov 27;160(21):3286-93
11088091
J Virol. 2010 Mar;84(6):2740-52
20042504
J Gen Virol. 2005 Dec;86(Pt 12):3385-3396
16298986
Genetics. 2006 Nov;174(3):1441-53
16951087
AIDS. 2004 Feb 20;18(3):413-9
15090792
Infect Genet Evol. 2005 Apr;5(3):239-46
15737915
J Infect Dis. 1999 Oct;180(4):1116-21
10479138
Bioinformatics. 2006 May 1;22(9):1064-71
16488909
J Virol. 2008 Apr;82(8):3952-70
18256145
J Immunol. 2002 Sep 15;169(6):3400-6
12218162
AIDS. 2000 Dec 1;14(17):2679-86
11125886
AIDS Res Hum Retroviruses. 2002 Sep 1;18(13):957-67
12230938
J Virol. 1997 Jul;71(7):4871-81
9188549
Evolution. 2007 Mar;61(3):666-74
17348929
BMC Evol Biol. 2007 Nov 08;7:214
17996036
Retrovirology. 2005 Jun 29;2:41
15985187
AIDS. 2006 Jan 2;20(1):29-34
16327316
Bioinformatics. 2008 Sep 1;24(17):1949-50
18562270
Retrovirology. 2008 Sep 08;5:78
18778482
PLoS Comput Biol. 2008 Dec;4(12):e1000240
19079613
Eur J Immunol. 2007 Dec;37(12):3435-44
18000954
Virology. 1993 Mar;193(1):528-30
8438591
J Virol. 1997 Oct;71(10):7498-508
9311829
Trends Microbiol. 2008 Dec;16(12):588-95
18964021