Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients.
Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of their hypotensive effects. Although consistent in their findings, these studies must be cautiously interpreted due to the limitations of study design and specific blood flow imaging modalities. The purpose of this review is to appraise and critically evaluate the current body of literature investigating the effects of combined treatment with topical carbonic anhydrase inhibitors and timolol in patients with glaucoma with respect to ocular blood flow, visual function, and optic nerve head structure.
Moss
Adam M
AM
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Harris
Alon
A
Siesky
Brent
B
Rusia
Deepam
D
Williamson
Kathleen M
KM
Shoshani
Yochai
Y
Ophthalmology. 2005 Mar;112(3):366-75
15745761
Acta Ophthalmol Scand. 1998 Feb;76(1):43-9
9541433
Acta Ophthalmol Scand. 1996 Dec;74(6):569-72
9017044
J Glaucoma. 1995 Aug;4(4):281-6
19920687
Acta Ophthalmol Scand. 2001 Aug;79(4):336-41
11453850
Arch Ophthalmol. 1995 Feb;113(2):216-21
7864755
J Glaucoma. 1997 Jun;6(3):175-9
9211141
J Glaucoma. 1999 Jun;8(3):164-71
10376255
Am J Ophthalmol. 1995 Aug;120(2):168-75
7639300
Curr Eye Res. 1997 Nov;16(11):1102-10
9395769
J Glaucoma. 1999 Feb;8(1):12-7
10084269
Br J Ophthalmol. 2005 Oct;89(10):1293-7
16170119
J Ocul Pharmacol Ther. 2006 Oct;22(5):353-61
17076630
Acta Ophthalmol Scand. 2005 Dec;83(6):716-22
16396650
Am J Ophthalmol. 2006 Jun;141(6):1158-60
16765700
Ophthalmology. 2001 Nov;108(11):1943-53
11713061
Ophthalmology. 1998 Jul;105(7):1146-64
9663215
J Glaucoma. 2007 Dec;16(8):700-3
18091458
Am J Ophthalmol. 2000 Oct;130(4):429-40
11024415
Prog Retin Eye Res. 2000 Jan;19(1):87-112
10614682
Clin Ther. 2008 Jun;30(6):1120-34
18640468
Acta Ophthalmol Scand Suppl. 2002;236:55-6
12390145
Int J Clin Pract. 2007 May;61(5):815-25
17343668
Surv Ophthalmol. 2009 Jan-Feb;54(1):33-46
19171209
Eur J Ophthalmol. 2009 Sep-Oct;19(5):790-7
19787599
Ophthalmology. 2000 Jul;107(7):1287-93
10889099
Ophthalmology. 2008 Oct;115(10):1728-34, 1734.e1-2
18538406
J Ultrasound Med. 1991 Jun;10(6):305-8
1895370
Curr Med Res Opin. 2006 Jan;22(1):67-73
16393432
Br J Ophthalmol. 1998 Nov;82(11):1249-53
9924327
Ophthalmology. 1998 Oct;105(10):1952-9
9787369
J Ocul Pharmacol Ther. 2009 Jun;25(3):239-48
19348600
Res Commun Mol Pathol Pharmacol. 1999 Mar;103(3):240-8
10509735
Graefes Arch Clin Exp Ophthalmol. 2006 Jul;244(7):795-801
16315043
Curr Eye Res. 2005 Mar;30(3):221-7
15804748
Br J Ophthalmol. 1999 Apr;83(4):466-9
10434872
Arch Ophthalmol. 1995 Jul;113(7):918-24
7605285
Invest Ophthalmol. 1975 Dec;14(12):935-7
1193808
Arch Ophthalmol. 2003 Dec;121(12):1711-5
14662590
Am J Ophthalmol. 2003 May;135(5):664-9
12719074
Br J Ophthalmol. 2002 Nov;86(11):1216-9
12386070
Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2448-53
10476818
Graefes Arch Clin Exp Ophthalmol. 2009 Nov;247(11):1531-8
19760224
Protein Sci. 1998 Mar;7(3):556-63
9541386
Acta Ophthalmol Scand. 2004 Dec;82(6):730-7
15606472
Ophthalmology. 2009 Feb;116(2):200-7
19019444
Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1436-41
3038771
J Glaucoma. 1997 Feb;6(1):23-32
9075077
Am Heart J. 1980 Aug;100(2):160-78
6105819
Br J Ophthalmol. 2006 Oct;90(10):1245-8
16825276
Am J Ophthalmol. 1998 Oct;126(4):498-505
9780094
Eye (Lond). 1993;7 ( Pt 1):122-6
8392006
Br Med J. 1978 Dec 9;2(6152):1598-600
728739
Am J Ophthalmol. 2003 Dec;136(6):1022-31
14644212
Graefes Arch Clin Exp Ophthalmol. 2006 Aug;244(8):978-83
16411100
Eye (Lond). 1995;9 ( Pt 1):29-33
7713247
Acta Ophthalmol Scand. 2003 Oct;81(5):474-9
14510794
Br J Ophthalmol. 2000 Sep;84(9):1008-12
10966955
Am J Ophthalmol. 2001 Oct;132(4):490-5
11589868
Acta Ophthalmol. 2008 Aug;86(5):552-7
18081900
Arch Ophthalmol. 2002 Jun;120(6):701-13; discussion 829-30
12049574
Klin Monbl Augenheilkd. 1999 Dec;215(6):361-6
10637801
Ophthalmology. 1997 Apr;104(4):653-8
9111259
Eye (Lond). 1993;7 ( Pt 5):697-702
8287997
Arch Neurol. 1961 Aug;5:227-32
13725995
Ophthalmologica. 2002 Mar-Apr;216(2):123-8
11919438
J Clin Invest. 1978 Sep;62(3):585-92
99455
Ophthalmology. 2000 Mar;107(3):430-4
10711877
Retina. 2008 Mar;28(3):493-7
18327144
Ophthalmology. 1999 Nov;106(11):2144-53
10571351
Int Ophthalmol. 1998;22(5):299-305
10826548
Acta Ophthalmol. 2010 Aug;88(5):541-52
19799592
Acta Ophthalmol Scand. 2006 Aug;84(4):475-80
16879567
J Glaucoma. 1997 Jun;6(3):143-5
9211135
Am Heart J. 1973 Jan;85(1):97-102
4629296
Arch Ophthalmol. 2002 Oct;120(10):1268-79
12365904
Graefes Arch Clin Exp Ophthalmol. 2007 Nov;245(11):1639-45
17457602
Am J Ophthalmol. 1994 Nov 15;118(5):642-9
7977577
Open Ophthalmol J. 2009 Sep 17;3:38-42
19816585
Br J Ophthalmol. 1993 Jan;77(1):25-9
8435394
Br J Ophthalmol. 2004 Aug;88(8):1049-54
15258023