A safe strategy to decrease fetal lead exposure in a woman with chronic intoxication.
During pregnancy skeletal lead is mobilized by maternal bone turnover and can threaten fetal development. The exact strategy suggested to women of childbearing age, who were chronically exposed to lead, and, thus, have high bone lead burden, is not well established. We describe 4 years of follow-up of a 29-year-old woman with chronic lead intoxication. We (a) advised her to delay conception until 'toxicological clearance', (b) treated her with multiple courses of lead chelator, DMSA, and (c) prescribed oral calcium. Patient had low blood lead and protoporphyrin level during pregnancy until delivery. Delaying conception, lead chelation, and calcium supplementation can decrease fetal exposure.
Leiba
Adi
A
Department of Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA. drleiba@gmail.com
Hu
Howard
H
Zheng
Amin
A
Kales
Stefanos N
SN
D000328:Adult; D002118:Calcium / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use*; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control*; D006801:Humans; D007855:Lead Poisoning / Q000188:drug therapy* / Q000517:prevention & control; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000517:prevention & control*; D004113:Succimer / Q000627:therapeutic use*
D002614:Chelating Agents; D004113:Succimer; D002118:Calcium
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