[Behavioral and molecular effects of endogenic kynurenines deficit in the honeybee (Apis mellifera L.)].
The importance of tryptophan endogenous metabolites kynurenines in the long-term memory and functioning of the signal cascade GluR - LIMK1 - F-actin, mediating the long-term memory trace storage, was demonstrated. The deficit of kynurenines induced by allopurinol (tryptophanoxygenase inhibitor) suppressed the long-term memory, decreased the LIMK1 expression, and paradoxically increased the F-actin content in the honeybee brain. These data agree with the earlier findings in drosophila mutant vermilion (the mutation of tryptophanoxygenase gene).
Lopatina
N G
NG
Zachepilo
T G
TG
Chesnokova
E G
EG
Savvateeva-Popova
E V
EV
D000199:Actins / Q000378:metabolism; D000493:Allopurinol / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001516:Bees / Q000378:metabolism / Q000502:physiology*; D001522:Behavior, Animal; D001921:Brain / Q000166:cytology / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007737:Kynurenine / Q000172:deficiency* / Q000235:genetics; D054461:Lim Kinases / Q000378:metabolism; D008568:Memory; D008969:Molecular Sequence Data; D009154:Mutation; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D000199:Actins; D004791:Enzyme Inhibitors; D017981:Receptors, Neurotransmitter; C069474:glutamine receptor; D007737:Kynurenine; D000493:Allopurinol; D014364:Tryptophan; D014366:Tryptophan Oxygenase; D054461:Lim Kinases