Proposed mechanism for lipoprotein remodelling in the brain.
Lipoprotein remodelling in the periphery has been extensively studied. For example, the processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during reverse cholesterol transport involves a series of enzymes, transporters in peripheral tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications and interconversions are well defined. Here, we present the hypothesis that a similar process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS) lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain.
Yu
Chunjiang
C
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Youmans
Katherine L
KL
LaDu
Mary J
MJ
D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008074:Lipoproteins / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D009457:Neuroglia / Q000378:metabolism / Q000502:physiology
D001057:Apolipoproteins E; D008074:Lipoproteins
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