title: Polybrominated diphenyl ethers and synthetic musks in umbilical cord serum, maternal serum, and breast milk from Seoul, South Korea.
abstract: Fetal and maternal exposure levels of two emerging pollutants, polybrominated diephenyl ethers (PBDEs) and synthetic musks, were measured in Korean general population to assess prenatal and postnatal exposures in infants. For this purpose, paired samples of breast milk, maternal and cord blood were collected from 20 Korean women in 2007. In comparison to data from other countries and previous data from Korea, relatively higher and gradually increasing concentrations for PBDEs were found in Korean breast milk (< LOQ to 590 ng g(-1) lipid wt; median=90 ng g(-1)). Differences in PBDEs and musk concentrations were found among age groups and parity levels. PBDEs concentrations in breast milk were lower in the younger mothers and/or the mothers with multiple parities, while these trends were not found for musks. Compared with PBDEs, concentrations of musks were significantly lower in breast milk than in serum and a little correlation in concentrations among the three human biological matrices were observed. The differences in the profiles of musks relative to PBDEs were due to different clearance rates between these two compounds. The average hazard quotients (HQs) for daily intake of PBDEs by infants via lactation were 0.62, 0.42, and 0.19 for BDE-47, BDE-99, and BDE-153, respectively.
authors.affiliation: Department of OB&GYN, KEPCO Medical Foundation, Hanil General Hospital, Seoul, Republic of Korea.
authors.forename: Chang Seong
authors.initials: CS
authors.lastname: Kang
authors.forename: Jong-Hyeon
authors.initials: JH
authors.lastname: Lee
authors.forename: Seung-Kyu
authors.initials: SK
authors.lastname: Kim
authors.forename: Kyu-Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Jung Suk
authors.initials: JS
authors.lastname: Lee
authors.forename: Pan Soo
authors.initials: PS
authors.lastname: Park
authors.forename: Se Hun
authors.initials: SH
authors.lastname: Yun
authors.forename: Kurunthachalam
authors.initials: K
authors.lastname: Kannan
authors.forename: Yung Wook
authors.initials: YW
authors.lastname: Yoo
authors.forename: Jeong Yi
authors.initials: JY
authors.lastname: Ha
authors.forename: Seung Wook
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000328:Adult; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D055768:Halogenated Diphenyl Ethers / Q000097:blood / Q000378:metabolism*; D006801:Humans; D018811:Maternal Exposure; D008895:Milk, Human / Q000378:metabolism*; D010476:Perfume / Q000378:metabolism*; D056910:Republic of Korea
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D010476:Perfume