Hypoxia-regulated angiogenic inhibitors.
The regulation of angiogenesis by hypoxia is an essential homeostatic mechanism that depends on a precise balance between positive and negative angiogenic regulatory molecules. Proangiogenic factors are well characterized; however, several in vivo and in vitro studies indicate that there are feedback mechanisms in place to inhibit angiogenesis during hypoxia. Understanding the signaling pathways leading to the negative feedback of angiogenesis will undoubtedly provide important tools to develop novel therapeutic strategies not only to enhance the angiogenic response in coronary artery disease but also to hinder deregulated angiogenesis in tumorigenesis.
Messmer-Blust
Angela
A
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
An
Xiaojin
X
Li
Jian
J
D020533:Angiogenesis Inhibitors / Q000378:metabolism*; D000818:Animals; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D051793:Hypoxia-Inducible Factor 1; D042461:Vascular Endothelial Growth Factor A
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