Molecular size of collagen peptide reverses the permeability of Caco-2 cells.
Intestinal permeability to size-classified fish collagen peptides (FCPs) was examined using Caco-2 monolayers. Minimum-sized FCPs were most efficiently transported across the Caco-2 monolayers. Permeability depended on peptide size. It was independent of the H(+)-coupled peptide transport system but was associated with tight junction permeability, suggesting that the paracellular pathway is responsible for transepithelial transport of collagen peptides.
Shimizu
Kazuo
K
R&D Center, Nippon Meat Packers, Inc, Tsukuba, Ibaraki, Japan. kazu.shimizu@nipponham.co.jp
Sato
Mikako
M
Zhang
Youzuo
Y
Kouguchi
Tomomi
T
Takahata
Yoshihisa
Y
Morimatsu
Fumiki
F
Shimizu
Makoto
M
D000818:Animals; D018938:Caco-2 Cells; D003094:Collagen / Q000737:chemistry*; D005399:Fishes; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism*; D010539:Permeability
D010446:Peptide Fragments; D003094:Collagen