Inflammatory networks during cellular senescence: causes and consequences.
Chronic inflammation is associated with aging and plays a causative role in several age-related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this chronic inflammation is often attributed to the progressive activation of immune cells over time. However, recent studies have shown that the process of cellular senescence, a tumor suppressive stress response that is also associated with aging, entails a striking increase in the secretion of proinflammatory proteins and might be an important additional contributor to chronic inflammation. Here, we list the secreted factors that make up the proinflammatory phenotype of senescent cells and describe the impact of these factors on tissue homeostasis. We also summarize the cellular pathways/processes that are known to regulate this phenotype--namely, the DNA damage response, microRNAs, key transcription factors and kinases and chromatin remodeling.
Freund
Adam
A
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Orjalo
Arturo V
AV
Desprez
Pierre-Yves
PY
Campisi
Judith
J
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs; D014157:Transcription Factors
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