title: A new highly versatile handle for chemistry on a solid support: the pipecolic linker.
abstract: The design, synthesis, and potential application of the pipecolic linker is presented. This new versatile handle can immobilize primary, secondary, and aromatic amines, as well as alcohols, phenols, and hydrazides, on a solid support. Compared with other linkers, the anchoring step is easy and efficient. The release of final products from the resin proceeds upon acidic treatment with high purities. The pipecolic linker offers the promise of being using in peptide chemistry to produce peptides modified at the N and C terminus, peptidomimetics, as well as small organic molecules.
authors.affiliation: Institut des Biomolécules Max Mousseron IBMM, UMR CNRS 5247, 15 avenue Charles Flahault, 34000 Montpellier, France.
authors.forename: Paweł
authors.initials: P
authors.lastname: Zajdel
authors.forename: Gaël
authors.initials: G
authors.lastname: Nomezine
authors.forename: Nicolas
authors.initials: N
authors.lastname: Masurier
authors.forename: Muriel
authors.initials: M
authors.lastname: Amblard
authors.forename: Maciej
authors.initials: M
authors.lastname: Pawłowski
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Gilles
authors.initials: G
authors.lastname: Subra
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D010875:Pipecolic Acids / Q000737:chemistry*
chemical_list: D000588:Amines; D006834:Hydrazines; D010455:Peptides; D010875:Pipecolic Acids