5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder.
Disturbances in the expression/function of the 5-HT2A receptor are implicated in autism. The association of the 5-HT2A receptor gene with autism was studied in the Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism.
Hranilovic
Dubravka
D
Department of Animal Physiology, Faculty of Science, University of Zagreb, and Psychiatric Hospital for Children and Youth, Zagreb, Croatia. dubravka@zg.biol.pmf.hr
Blazevic
Sofia
S
Babic
Marina
M
Smurinic
Maja
M
Bujas-Petkovic
Zorana
Z
Jernej
Branimir
B
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D017523:Croatia / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D055815:Young Adult
D044402:Receptor, Serotonin, 5-HT2A