title: Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging.
abstract: Dopamine has been hypothesized to provide the basis for the interaction between motivational and cognitive control. However, there is no evidence for this hypothesis in humans. We fill this gap by using fMRI, a novel behavioral paradigm and a common polymorphism in the DAT1 gene (SLC6A3). Carriers of the 9-repeat (9R) allele of a 40 base pair repeat polymorphism in the 3' untranslated region of DAT1, associated with high striatal dopamine, showed greater activity in the ventromedial striatum during reward anticipation than homozygotes for the 10-repeat allele, replicating previous genetic imaging studies. The crucial novel finding is that 9R carriers also exhibited a greater influence of anticipated reward on switch costs, as well as greater activity in the dorsomedial striatum during task switching in anticipation of high reward relative to low reward. These data establish a crucial role for human striatal dopamine in the modulation of cognitive flexibility by reward anticipation, thus, elucidating the neurochemical mechanism of the interaction between motivation and cognitive control.
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands. e.aarts@donders.ru.nl
authors.forename: Esther
authors.initials: E
authors.lastname: Aarts
authors.forename: Ardi
authors.initials: A
authors.lastname: Roelofs
authors.forename: Barbara
authors.initials: B
authors.lastname: Franke
authors.forename: Mark
authors.initials: M
authors.lastname: Rijpkema
authors.forename: Guillén
authors.initials: G
authors.lastname: Fernández
authors.forename: Rick C
authors.initials: RC
authors.lastname: Helmich
authors.forename: Roshan
authors.initials: R
authors.lastname: Cools
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D003342:Corpus Striatum / Q000098:blood supply / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009042:Motivation / Q000235:genetics*; D010100:Oxygen / Q000097:blood; D011110:Polymorphism, Genetic / Q000235:genetics*; D012201:Reward; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human; D010100:Oxygen; D004298:Dopamine
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