title: Looking for a 5-HT7 radiotracer for positron emission tomography.
abstract: In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation.
authors.affiliation: Université de Lyon, Université Lyon 1, CNRS, ICBMS (UMR CNRS 5246), Lyon, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Andriès
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Lemoine
authors.forename: Alice
authors.initials: A
authors.lastname: Mouchel-Blaisot
authors.forename: Sandrine
authors.initials: S
authors.lastname: Tang
authors.forename: Mathieu
authors.initials: M
authors.lastname: Verdurand
authors.forename: Didier
authors.initials: D
authors.lastname: Le Bars
authors.forename: Luc
authors.initials: L
authors.lastname: Zimmer
authors.forename: Thierry
authors.initials: T
authors.lastname: Billard
mesh_terms: D000818:Animals; D001345:Autoradiography; D001565:Benzoates / Q000737:chemistry / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D005462:Fluorine Radioisotopes; D057927:Hydrophobic and Hydrophilic Interactions; D007553:Isotope Labeling; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis*
chemical_list: D001565:Benzoates; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor; C022893:4-fluorobenzoic acid