title: Octreotide reduces hepatic, renal and breast cystic volume in autosomal-dominant polycystic kidney disease.
abstract: A 43-year-old woman with autosomal-dominant polycystic kidney disease (ADPKD) received octreotide for 12 months, and this was associated with a 6.3% reduction in liver volume, an 8% reduction in total kidney volume and stabilization of renal function. There was also a reduction of cyst size in fibrocystic disease of breast. These data suggest that the cyst fluid accumulation in different organs from patients with ADPKD is a dynamic process which can be reversed by octreotide. This is the first report of a case of simultaneous reduction in hepatic, renal and breast cystic volume with preservation of renal function in a patient with ADPKD receiving octreotide.
authors.affiliation: Servicio de Nefrología, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain. cpeces@varnetmail.com
authors.forename: Ramón
authors.initials: R
authors.lastname: Peces
authors.forename: Emilio
authors.initials: E
authors.lastname: Cuesta-López
authors.forename: Carlos
authors.initials: C
authors.lastname: Peces
authors.forename: Virginia
authors.initials: V
authors.lastname: Pérez-Dueñas
authors.forename: Cristina
authors.initials: C
authors.lastname: Vega-Cabrera
authors.forename: Rafael
authors.initials: R
authors.lastname: Selgas
mesh_terms: D000328:Adult; D047688:Breast Cyst / Q000188:drug therapy* / Q000209:etiology*; D003560:Cysts / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000188:drug therapy* / Q000209:etiology*; D008107:Liver Diseases / Q000188:drug therapy* / Q000209:etiology*; D015282:Octreotide / Q000627:therapeutic use*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*
chemical_list: D015282:Octreotide
references.citation: J Am Soc Nephrol. 2008 Mar;19(3):631-8
references.pmid: 18199797
references.citation: Int J Clin Exp Pathol. 2008 Jan 01;1(1):84-90
references.pmid: 18784826
references.citation: Am J Physiol Renal Physiol. 2007 Jan;292(1):F11-4
references.pmid: 16940560
references.citation: Nephron. 1997;77(3):304-8
references.pmid: 9375824
references.citation: Iran J Kidney Dis. 2009 Oct;3(4):246-8
references.pmid: 19841531
references.citation: N Engl J Med. 2006 May 18;354(20):2122-30
references.pmid: 16707749
references.citation: N Engl J Med. 1996 Jan 25;334(4):246-54
references.pmid: 8532003
references.citation: Kidney Int. 2009 Jan;75(2):235-41
references.pmid: 18971924
references.citation: Gut. 2008 Sep;57(9):1338-9
references.pmid: 18719151
references.citation: Gastroenterology. 2009 Nov;137(5):1661-8.e1-2
references.pmid: 19646443
references.citation: Kidney Int. 2005 Jul;68(1):206-16
references.pmid: 15954910
references.citation: Am J Surg. 2004 Oct;188(4):443-7
references.pmid: 15474446
references.citation: Gastroenterology. 2007 Mar;132(3):1104-16
references.pmid: 17383431
references.citation: NDT Plus. 2009 Apr;2(2):133-5
references.pmid: 25949309