Complex regional pain syndrome type I: neuropathic or not?
Complex regional pain syndrome (CRPS) is clinically characterized by pain, abnormal regulation of blood flow and sweating, edema of skin and subcutaneous tissues, active and passive movement disorders, and trophic changes. It is classified as type I (reflex sympathetic dystrophy) and type II (causalgia). CRPS cannot be reduced to one system or to one mechanism only. In the past decades, there has been absolutely no doubt that complex regional pain syndromes have to be classified as neuropathic pain disorders. This situation changed when a proposal to redefine neuropathic pain states was recently published, which resulted in an exclusion of CRPS from neuropathic pain disorders. We analyzed the strength of the scientific evidence that supports the neuropathic nature of complex regional pain syndromes.
Naleschinski
Dennis
D
Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, Haus 41, 24105, Kiel, Germany. d.naleschinski@neurologie.uni-kiel.de
Baron
Ralf
R
D020918:Complex Regional Pain Syndromes / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D009437:Neuralgia / Q000503:physiopathology*
Pain. 2006 Feb;120(3):235-243
16427737
Pain. 2007 Nov;132(1-2):195-205
17890011
Pain. 2000 Nov;88(2):161-168
11050371
Mediators Inflamm. 2002 Feb;11(1):47-51
11930962
Pain. 2006 Feb;120(3):244-266
16427199
Pain. 2007 Aug;130(3):287-293
17499924
Rev Rhum Mal Osteoartic. 1983 Apr;50(4):255-60
6879092
Brain. 2004 May;127(Pt 5):1159-71
14985268
Pain. 2005 Aug;116(3):213-219
15964681
Brain. 2001 Mar;124(Pt 3):587-99
11222458
Pain. 2009 Jun;143(3):246-251
19375222
Pain. 1993 Nov;55(2):151-157
8309706
Lancet. 2004 Nov 13-19;364(9447):1739-41
15541435
Lancet. 2002 May 11;359(9318):1655-60
12020526
Q J Nucl Med. 1996 Jun;40(2):188-93
8909105
Pain. 2001 Apr;91(3):251-257
11275381
Pain Med. 2008 Apr;9(3):354-8
18366513
Eur J Pain. 2008 Aug;12(6):716-21
18055234
Neurology. 2006 Aug 22;67(4):673-5
16924021
Brain. 2007 Oct;130(Pt 10):2671-87
17575278
Pain. 2003 May;103(1-2):199-207
12749974
Pain. 2008 Aug 15;138(1):226-232
18539395
Pain. 2006 Feb;120(3):227-229
16426757
Ann N Y Acad Sci. 2007 Jun;1107:168-73
17804544
Neurology. 2005 Jul 26;65(2):311-3
16043808
Muscle Nerve. 1999 Jun;22(6):678-95
10366221
Neurology. 2008 Apr 29;70(18):1630-5
18003941
Skeletal Radiol. 1998 May;27(5):262-5
9638836
Pain. 2009 Apr;142(3):218-224
19195784
Neurology. 2001 Dec 26;57(12):2179-84
11756594
Pain. 2007 May;129(1-2):12-20
17084977
Anesth Analg. 2007 Oct;105(4):1148-51, table of contents
17898403