title: Animal models of neurological disease.
abstract: The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology. These models have been the source of a plethora of information, such as the importance of certain molecular mechanisms and genetic contributions in neurological disease. Additionally, animal models have been utilized in the discovery and testing of possible therapeutic treatments. Although most neurological diseases are still not yet completely understood and reliable treatment is lacking, animal models provide a major step in the right direction.
authors.affiliation: UCSD School of Medicine, San Diego, California, USA.
authors.forename: Amol
authors.initials: A
authors.lastname: Shah
authors.forename: Tomas
authors.initials: T
authors.lastname: Garzon-Muvdi
authors.forename: Rohit
authors.initials: R
authors.lastname: Mahajan
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Duenas
authors.forename: Alfredo
authors.initials: A
authors.lastname: Quiñones-Hinojosa
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D018663:Adrenergic Agents / Q000494:pharmacology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology; D002490:Central Nervous System / Q000187:drug effects / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D008694:Methamphetamine / Q000494:pharmacology; D009422:Nervous System Diseases / Q000473:pathology / Q000503:physiopathology; D009498:Neurotoxins / Q000494:pharmacology; D016627:Oxidopamine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012402:Rotenone / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D018663:Adrenergic Agents; D016564:Amyloid beta-Protein Precursor; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D009498:Neurotoxins; D014475:Uncoupling Agents; D012402:Rotenone; D008694:Methamphetamine; D012110:Reserpine; D016627:Oxidopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine