title: [Incretins: do they exert cardiovascular effects?].
abstract: The physiological effects of the incretin hormone glucagon-like peptide-(GLP-)1 have contributed to the important role that incretin-based therapies with GLP-1 analogs or dipeptidyl peptidase-(DPP-)4 inhibitors already play in type 2 diabetes treatment. This development is not only due to the glucose-dependent insulinotropic effect of GLP-1 as well as the positive effects on beta cell function and, probably, beta cell mass, but also to the beneficial effects on body weight.Lately, the data on positive cardiovascular effects of GLP-1 have been growing. In animal models, GLP-1 improves left ventricular function and diminishes myocardial defects in ischemia models. In clinical studies with GLP-1 analogs, a normalization of blood pressure was observed and some of the data from animal studies after myocardial infarction or after invasive cardiologic or cardiosurgical interventions were also found under clinical conditions in humans. Additionally, an improvement of cardiovascular surrogate parameters was observed with incretin-based therapies. This review gives an overview on the cardiovascular effects of GLP-1 and incretin-based therapies.
authors.affiliation: Medizinische Klinik IV, Universitätsklinikum Tübingen, Tübingen, Germany. baptist.gallwitz@med.uni-tuebingen.de
authors.forename: Baptist
authors.initials: B
authors.lastname: Gallwitz
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000378:metabolism*; D006331:Heart Diseases / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D008955:Models, Cardiovascular
chemical_list: D054795:Incretins
references.citation: Diabetes Care. 2005 May;28(5):1083-91
references.pmid: 15855571
references.citation: Diabetologia. 1993 Aug;36(8):741-4
references.pmid: 8405741
references.citation: J Pharmacol Exp Ther. 2005 Jan;312(1):303-8
references.pmid: 15356213
references.citation: Curr Med Res Opin. 2008 Jan;24(1):275-86
references.pmid: 18053320
references.citation: Lancet. 2009 Jul 4;374(9683):39-47
references.pmid: 19515413
references.citation: IDrugs. 2008 Jul;11(7):497-501
references.pmid: 18600596
references.citation: Circ Res. 2007 Feb 16;100(3):299-301
references.pmid: 17307968
references.citation: Lancet. 2009 Feb 7;373(9662):473-81
references.pmid: 18819705
references.citation: Diabetes. 1999 Apr;48(4):839-47
references.pmid: 10102702
references.citation: Diabetes Care. 2004 Nov;27(11):2628-35
references.pmid: 15504997
references.citation: J Am Coll Cardiol. 2009 Feb 10;53(6):501-10
references.pmid: 19195607
references.citation: Acta Physiol Scand. 1997 Aug;160(4):413-22
references.pmid: 9338524
references.citation: JAMA. 2007 Jul 11;298(2):194-206
references.pmid: 17622601
references.citation: Am J Cardiol. 2007 Sep 1;100(5):824-9
references.pmid: 17719327
references.citation: Diabetologia. 2009 Oct;52(10):2046-55
references.pmid: 19688338
references.citation: Endocrinology. 1996 Jul;137(7):2968-78
references.pmid: 8770921
references.citation: Am J Physiol. 1999 Nov;277(5):E784-91
references.pmid: 10567003
references.citation: Endocrinology. 2000 Dec;141(12):4600-5
references.pmid: 11108273
references.citation: J Clin Invest. 1993 Jan;91(1):301-7
references.pmid: 8423228
references.citation: Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206
references.pmid: 15271645
references.citation: Diabetes Care. 2007 Jul;30(7):1901-3
references.pmid: 17468349
references.citation: Diabetes Metab. 2008 Feb;34 Suppl 2:S73-7
references.pmid: 18640589
references.citation: Endocrinology. 2003 Jun;144(6):2242-52
references.pmid: 12746281
references.citation: Regul Pept. 1999 Nov 30;85(1):9-24
references.pmid: 10588446
references.citation: Transplantation. 2007 Jan 15;83(1):24-8
references.pmid: 17220786
references.citation: Diabet Med. 2009 Mar;26(3):268-78
references.pmid: 19317822
references.citation: Curr Atheroscler Rep. 2009 Mar;11(2):93-9
references.pmid: 19228481
references.citation: Diabetes Obes Metab. 2006 Jul;8(4):436-47
references.pmid: 16776751
references.citation: J Med Chem. 2000 May 4;43(9):1664-9
references.pmid: 10794683
references.citation: Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1209-15
references.pmid: 15353407
references.citation: Diabetes Obes Metab. 2009 Dec;11(12):1163-72
references.pmid: 19930006
references.citation: Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E701-7
references.pmid: 12773303
references.citation: J Pharmacol Exp Ther. 2006 Jun;317(3):1106-13
references.pmid: 16489128
references.citation: Diabetes. 2000 May;49(5):741-8
references.pmid: 10905482
references.citation: Circulation. 2007 Mar 27;115(12):1544-50
references.pmid: 17353438
references.citation: Diabetes Care. 2009 Jan;32(1):84-90
references.pmid: 18931095
references.citation: Curr Med Res Opin. 2008 Oct;24(10):2943-52
references.pmid: 18786299
references.citation: Horm Metab Res. 2001 Feb;33(2):73-7
references.pmid: 11294496
references.citation: Lancet. 2002 Mar 9;359(9309):824-30
references.pmid: 11897280
references.citation: Diabetes Care. 2008 Aug;31(8):1582-4
references.pmid: 18458146
references.citation: Diabet Med. 2008 Sep;25(9):1129-31
references.pmid: 19183322
references.citation: Lancet. 2006 Nov 11;368(9548):1696-705
references.pmid: 17098089
references.citation: Diabetes Care. 2006 Dec;29(12):2632-7
references.pmid: 17130196
references.citation: Diabetes. 2000 Jun;49(6):883-8
references.pmid: 10866038
references.citation: J Endocrinol. 2009 Apr;201(1):59-66
references.pmid: 19136619
references.citation: Am J Physiol. 1997 Nov;273(5):E981-8
references.pmid: 9374685
references.citation: Regul Pept. 2008 Feb 7;146(1-3):243-9
references.pmid: 17976835
references.citation: Am J Med. 2009 Jun;122(6 Suppl):S11-24
references.pmid: 19464424
references.citation: N Engl J Med. 2001 May 3;344(18):1343-50
references.pmid: 11333990
references.citation: Diabetes. 1995 Dec;44(12):1433-7
references.pmid: 7589851
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2704-10
references.pmid: 15181045
references.citation: Circulation. 2004 Aug 24;110(8):955-61
references.pmid: 15313949
references.citation: Circulation. 2004 Mar 2;109(8):962-5
references.pmid: 14981009
references.citation: J Endocrinol. 2008 Jan;196(1):57-65
references.pmid: 18180317
references.citation: Diabetes Care. 2005 May;28(5):1092-100
references.pmid: 15855572
references.citation: Curr Opin Pharmacol. 2004 Dec;4(6):589-96
references.pmid: 15525549
references.citation: Diabetes. 2008 Oct;57(10):2577-87
references.pmid: 18633100
references.citation: Auton Neurosci. 2004 Jan 30;110(1):36-43
references.pmid: 14766323
references.citation: Curr Diabetes Rev. 2008 May;4(2):101-9
references.pmid: 18473757
references.citation: Diabetologia. 2002 Feb;45(2):195-202
references.pmid: 11935150
references.citation: Horm Metab Res. 2006 Dec;38(12):838-44
references.pmid: 17163361
references.citation: Acta Physiol Scand. 1996 Jul;157(3):355-7
references.pmid: 8830893
references.citation: Clin Ther. 2007 Jan;29(1):139-53
references.pmid: 17379054
references.citation: Endocrinology. 2003 Dec;144(12):5149-58
references.pmid: 12960095
references.citation: Gastroenterology. 2007 May;132(6):2131-57
references.pmid: 17498508
references.citation: Circulation. 2008 May 6;117(18):2340-50
references.pmid: 18427132
references.citation: Diabetes Care. 2007 Jun;30(6):1608-10
references.pmid: 17372153
references.citation: Diabetes. 2008 Aug;57(8):2046-54
references.pmid: 18487451
references.citation: Diabetes. 2009 Apr;58(4):975-83
references.pmid: 19151200
references.citation: Am J Cardiol. 2008 Sep 1;102(5):646-7
references.pmid: 18721530
references.citation: Diabetes Care. 2009 Jul;32(7):1224-30
references.pmid: 19289857
references.citation: Peptides. 1992 Jan-Feb;13(1):13-6
references.pmid: 1320261
references.citation: Diabetes Care. 1998 May;21(5):695-700
references.pmid: 9589226
references.citation: Diabetes. 2005 Jan;54(1):146-51
references.pmid: 15616022
references.citation: Clin Endocrinol (Oxf). 2009 Mar;70(3):343-53
references.pmid: 18771570
references.citation: Regul Pept. 2005 Feb 15;125(1-3):173-7
references.pmid: 15582729
references.citation: J Clin Endocrinol Metab. 1995 Mar;80(3):952-7
references.pmid: 7883856
references.citation: J Biol Chem. 1992 Apr 15;267(11):7402-5
references.pmid: 1313797
references.citation: Prim Care. 2006 Dec;33(4):887-901
references.pmid: 17169672
references.citation: Diabetes. 2009 Aug;58(8):1816-25
references.pmid: 19401425
references.citation: J Clin Invest. 2002 Jul;110(1):43-52
references.pmid: 12093887
references.citation: Am J Med. 2009 Jun;122(6 Suppl):S3-S10
references.pmid: 19464426