Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities.
Two new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 1-10 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 8-10 exhibited cytotoxic activities with IC(50) values ranging from 3.4 to 6.6microM.
Wu
Jia-Jun
JJ
Key Laboratory of Modern Chinese Medicine, China Pharmaceutical University, Nanjing 210009, PR China.
Cheng
Ka-Wing
KW
Zuo
Xiao-Feng
XF
Wang
Ming-Fu
MF
Li
Ping
P
Zhang
Lu-Yong
LY
Wang
Hao
H
Ye
Wen-Cai
WC
D027761:Asparagus Plant / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004441:Ecdysterone / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
D010936:Plant Extracts; D012503:Saponins; C543297:filiasparoside C; D004441:Ecdysterone