An obesity drug sibutramine reduces brain natriuretic peptide (BNP) levels in severely obese patients.
OBJECTIVE
Sibutramine is a selective inhibitor of the reuptake of monoamines. Plasma levels of brain natriuretic peptide (BNP) appear to be inversely associated with body mass index (BMI) in subjects with and without heart failure for reasons that remain unexplained. The aim of this study was to investigate the possible influence of sibutramine treatment on BNP levels in severely obese patients.


METHODS
Fifty-two severely obese female patients with BMI > 40 kg/m(2) were included to this study. The women were recommended to follow a weight-reducing daily diet of 25 kcal/kg of ideal body weight. During the treatment period, all patients were to receive 15 mg of sibutramine once a day. Blood chemistry tests were performed before the onset of the medication and after 12 weeks of treatment.


RESULTS
None of the subjects was withdrawn from the study because of the adverse effects of sibutramine. Body weight (108.8 +/- 13.3 kg vs. 101.7 +/- 15.6 kg, p < 0.001), BMI (44.6 +/- 4.6 kg/m(2) vs. 41.8 +/- 5.7 kg/m(2), p < 0.001) and BNP [8.6 (0.5-49.5) ng/l vs. 3.1 (0.2-28.6) ng/l, p = 0.018] levels were significantly decreased after 12 weeks of sibutramine treatment. Total cholesterol (5.19 +/- 0.90 mmol/l vs. 4.82 +/- 1.05 mmol/l respectively; p < 0.001), low-density lipoprotein-cholesterol (3.26 +/- 0.86 mmol/l vs. 2.99 +/- 0.40 mmol/l respectively; p = 0.008), levels were significantly decreased; however, there was no significant alteration in high-density lipoprotein-cholesterol and triglyceride levels.


CONCLUSIONS
This study has shown a decrease in BNP levels which may lead to improvement in cardiac outcome after sibutramine treatment. Further randomised studies are needed to be conducted to clarify the relationship between sibutramine and BNP.
Taner Ertugrul
D
D
Department of Internal Medicine, Kecioren Teaching and Research Hospital, Ankara, Turkey.
Yavuz
B
B
Okhan Akin
K
K
Arif Yalcin
A
A
Ata
N
N
Kucukazman
M
M
Algul
B
B
Dal
K
K
Sinan Deveci
O
O
Tutal
E
E
D001067:Appetite Depressants / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000378:metabolism; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D009765:Obesity / Q000188:drug therapy*
D001067:Appetite Depressants; D015415:Biomarkers; D008078:Cholesterol, LDL; D003503:Cyclobutanes; D020097:Natriuretic Peptide, Brain; C058254:sibutramine