title: Prevalence of allelic loss at TP53 in endometrial carcinomas.
abstract: Alterations within the TP53 tumor suppressor belong to the most common genetic features reported in various human neoplasms, including endometrial cancer. In this article, the prevalence of allelic loss at the TP53 locus in primary human endometrial carcinomas (ECs) is discussed. Furthermore, we reviewed the role of allelic imbalance at 17p13.1 in metastatic human ECs on the basis of a literature review and on recently published data ascertained by our laboratory staff.
authors.affiliation: 2nd Department of Gynecology, Lublin Medical University, PL-20-954 Lublin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Semczuk
authors.forename: Regine
authors.initials: R
authors.lastname: Schneider-Stock
authors.forename: Wiktor
authors.initials: W
authors.lastname: Szewczuk
mesh_terms: D000368:Aged; D000483:Alleles; D002277:Carcinoma / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D003062:Codon; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010641:Phenotype; D011379:Prognosis
chemical_list: D003062:Codon