title: Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression.
abstract: Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.
authors.affiliation: Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA. jjm@columbia.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Mann
authors.forename: D M
authors.initials: DM
authors.lastname: Currier
mesh_terms: D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D044127:Epigenesis, Genetic; D006801:Humans; D013315:Stress, Psychological / Q000235:genetics / Q000523:psychology*; D013405:Suicide / Q000523:psychology*
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