Working memory impairment in multiple sclerosis relapsing-remitting patients with episodic memory deficits.
Episodic memory is impaired in multiple sclerosis (MS) patients, possibly because of deficits in working memory (WM) functioning. If so, WM alterations should necessarily be found in patients with episodic memory deficits, but this has not yet been demonstrated. In this study we aimed at determining whether episodic memory deficits in relapsing-remitting MS are found in conjunction with impaired WM. We evaluated 32 MS patients and 32 matched healthy controls. Nineteen of the 32 patients had episodic memory impairment, and as a group only these individuals showed deficits in WM capacity, which may lead to difficulty in encoding, and/or retrieving information from episodic memory.
Fuso
Simone Freitas
SF
Department of Psychobiology, Federal University of São Paulo, São Paulo, SP, Brazil.
Callegaro
Dagoberto
D
Pompéia
Sabine
S
Bueno
Orlando F A
OF
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008570:Memory, Short-Term / Q000502:physiology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000503:physiopathology / Q000523:psychology*; D009483:Neuropsychological Tests