title: [Morbidity of Chagas disease among autochthonous patients from the Rio Negro microregion, State of Amazonas].
abstract: BACKGROUND
  A seroepidemiological and clinical study was conducted on 152 autochthonous individuals living in the district of Barcelos, State of Amazonas, to evaluate the seroprevalence of Chagas infection and morbidity of Chagas disease.
  
  
  METHODS
  The serological tests used were indirect immunofluorescence, conventional and recombinant ELISA and immunoblot (Tesa-blot). Thirty-eight patients were considered seropositive; 31 were considered serodoubtful; and 83 were considered seronegative. The 38 seropositive cases were paired with 38 seronegative controls of the same age and sex, and underwent epidemiological and clinical evaluations, electrocardiograms and echocardiograms. Twenty-nine pairs underwent radiological examinations of the esophagus.
  
  
  RESULTS
  Seropositivity was 19.9 times more frequent among workers gathering plant materials from the forests and 10.4 times more frequent among piassaba gatherers. Eighty six point seven percent of the seropositive individuals recognized the genus Rhodnius as the local vector, while only 34.2% of the seronegative individuals recognized this. The EKG was abnormal in 36.8% of the seropositive individuals and in 21.5% of the seronegative individuals, while the echocardiogram showed abnormalities in 31.6% of the seropositive and 18.4% of the seronegative individuals. Precordialgia and palpitation were more frequent among the seropositive individuals. Clinical evaluation on the digestive system and X-ray on the esophagus did not show significant abnormalities.
  
  
  CONCLUSIONS
  Chagas disease in the study region can be considered to be an occupational disease.
authors.affiliation: Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. brum24@gmail.com
authors.forename: Lucia Maria
authors.initials: LM
authors.lastname: Brum-Soares
authors.forename: Sérgio Salles
authors.initials: SS
authors.lastname: Xavier
authors.forename: Andréa Silvestre de
authors.initials: AS
authors.lastname: Sousa
authors.forename: José
authors.initials: J
authors.lastname: Borges-Pereira
authors.forename: João Marcos Bemfica Barbosa
authors.initials: JM
authors.lastname: Ferreira
authors.forename: Inez Ribeiro
authors.initials: IR
authors.lastname: Costa
authors.forename: Angela Cristina Verissimo
authors.initials: AC
authors.lastname: Junqueira
authors.forename: José Rodrigues
authors.initials: JR
authors.lastname: Coura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D014355:Chagas Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D002908:Chronic Disease; D004452:Echocardiography; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007303:Insect Vectors; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000469:parasitology; D012239:Rhodnius; D016036:Seroepidemiologic Studies; D055815:Young Adult