title: Comparison of the effects of Puumala and Dobrava viruses on early and long-term renal outcomes in patients with haemorrhagic fever with renal syndrome.
abstract: OBJECTIVE
  The clinical course and outcome of patients with haemorrhagic fever with renal syndrome (HFRS) caused by Puumala (PUUV) and Dobrava viruses (DOBV) were analyzed and whether it left long-term consequences on kidney function after 10 years was evaluated.
  
  
  METHODS
  Cross-sectional studies were conducted to test the kidney function and blood pressure of HFRS-affected patients and to follow them up 10 years after. Eighty-two PUUV- and 53 DOBV-induced HFRS patients and 14 and 31 participants 10 years after having contracted PUUV- and DOBV-related diseases, respectively were evaluated.
  
  
  RESULTS
  Serum creatinine concentrations were 279.5 and 410 mcmol/L in PUUV and DOBV groups, respectively (P = 0.005). There were six and 13 anuric (P < 0.05), none and seven dialysis-dependant (P < 0.05), and nine and 18 hypotensive patients (P < 0.05) in PUUV and DOBV groups, respectively. After 10 years, glomerular filtration rates were 122.1 + or - 11.1 and 104.7 + or - 20.2 mL/min (P < 0.05) in PUUV and DOBV groups, respectively.
  
  
  CONCLUSIONS
  During the acute phase, DOBV causes more severe renal impairment than PUUV infection. After 10 years follow up, renal function was found within normal limits, although after DOBV infection glomerular filtration rate (GFR) was significantly lower than after PUUV infection.
authors.affiliation: University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors.forename: Denijal
authors.initials: D
authors.lastname: Tulumovic
authors.forename: Goran
authors.initials: G
authors.lastname: Imamovic
authors.forename: Enisa
authors.initials: E
authors.lastname: Mesic
authors.forename: Mirsada
authors.initials: M
authors.lastname: Hukic
authors.forename: Ajsa
authors.initials: A
authors.lastname: Tulumovic
authors.forename: Alma
authors.initials: A
authors.lastname: Imamovic
authors.forename: Enver
authors.initials: E
authors.lastname: Zerem
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D017522:Bosnia and Herzegovina; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006476:Orthohantavirus / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D007022:Hypotension / Q000503:physiopathology / Q000821:virology; D007668:Kidney / Q000503:physiopathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D029262:Puumala virus / Q000472:pathogenicity*; D006435:Renal Dialysis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D003404:Creatinine