title: 3D shortcuts to gene regulation.
abstract: Recent technologies have allowed high-resolution genome-wide binding profiles of numerous transcription factors and other proteins. A widespread observation has emerged from studies in diverse mammalian systems: most binding events are located at great distances from gene promoters. It is becoming apparent that the traditional one-dimensional view of gene regulation via the proximal cis regulatory elements is over-simplified. True proximity and functional relevance can be revealed by studying the three-dimensional structure of the genome packaged inside the nucleus. Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field.
authors.affiliation: Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Ofir
authors.initials: O
authors.lastname: Hakim
authors.forename: Myong-Hee
authors.initials: MH
authors.lastname: Sung
authors.forename: Gordon L
authors.initials: GL
authors.lastname: Hager
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009687:Nuclear Proteins / Q000378:metabolism; D009690:Nucleic Acid Conformation
chemical_list: D009687:Nuclear Proteins
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