title: Genetic chemistry: production of non-native compounds in yeast.
abstract: The tools and perspectives that chemists bring to the study of biological systems have yielded very important discoveries and opened many new research possibilities over the years (Hopkins AL: Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008, 11:682-690; Lehar J, Stockwell BR, Giaever G, Nislow C: Combination chemical genetics. Nat Chem Biol 2008, 11:674-681. This work describes use of genome level data to discover and understand higher order pleiotropic effects of combinations of drugs). Chemical biology has an ever-growing toolbox that has been expanding its reach into many different aspects of the study and utilization of biological systems (Strombergsson H, Kleywegt G: A chemogenomic view on protein-ligand spaces. BMC Bioinformatics 2009, 10(Suppl 6):S13; Bumpus BB, Evens BS, Thomas PM, Ntai I, Kelleher NI: A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol 2009, 27:951-956. This reviews techniques that allow for the identification of biochemical pathways that produce molecules of interest under very specific situations; Altamn KH, Buchner J, Kessler H, Diederich F, Krautler B, Lippard S, Liskamp R, Muller K, Nolan EM, Samori B, et al.: The state of the art of chemical biology. Chembiochem 2009, 10:16-29) including the study and utilization of biological systems in yeast. This review will describe recent successes in the use of yeast for both discovery and production of non-native secondary metabolites focused on pharmaceutically relevant compounds.
authors.affiliation: Genetic Chemistry Inc. (Evolva Holding Company), 2440 Embarcadero Way, Palo Alto, CA 94303, USA. sgoldman@geneticchemistry.com
authors.forename: Stanley
authors.initials: S
authors.lastname: Goldman
mesh_terms: D022201:Chromosomes, Artificial; D055808:Drug Discovery / Q000379:methods; D005818:Genetic Engineering / Q000379:methods*; D053858:Metabolic Networks and Pathways; D008967:Molecular Biology / Q000379:methods*; D015003:Yeasts / Q000235:genetics* / Q000378:metabolism*