title: The hydrolysis of phosphate diesters in cyclohexane and acetone.
abstract: The hydrolysis of phosphate diesters is one of the most difficult reactions known. Here we show that in acetone or cyclohexane, at 25 degrees C, phosphodiesters undergo hydrolysis 5 x 10(5) and 2 x 10(9)-fold more rapidly than in water, respectively, and that this rate enhancement is achieved by lowering the enthalpy of activation.
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Randy B
authors.initials: RB
authors.lastname: Stockbridge
authors.forename: Richard
authors.initials: R
authors.lastname: Wolfenden
mesh_terms: D000096:Acetone / Q000737:chemistry*; D003510:Cyclohexanes / Q000737:chemistry*; D004952:Esters; D006868:Hydrolysis; D010710:Phosphates / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D003510:Cyclohexanes; D004952:Esters; D010710:Phosphates; D000096:Acetone; C506365:Cyclohexane
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