title: Biomarkers of peripheral arterial disease.
abstract: Atherosclerotic arterial occlusive disease affecting the lower extremities is also known as peripheral artery disease (PAD). This disorder affects 8 to 12 million individuals in the U.S. and is increasingly prevalent in Europe and Asia. Unfortunately, most patients are not diagnosed and are not optimally treated. A blood test for PAD, if sufficiently sensitive and specific, would be expected to improve recognition and treatment of these individuals. Even a biomarker panel of moderate sensitivity and specificity for PAD could refine risk stratification to select individuals for diagnostic vascular examination. Alternatively, biomarkers for PAD may be useful in determining prognosis, the risk for progression, or the response to therapy. Finally, the discovery of biomarkers associated with PAD may provide novel insights into the pathophysiology of PAD and new therapeutic avenues to pursue. Biomarkers may be derived from studies of the genome, transcriptome, proteome, or metabolome. The focus of this review is on proteomic biomarkers associated with PAD.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University, Stanford, California 94305-5406, USA. john.cooke@stanford.edu
authors.forename: John P
authors.initials: JP
authors.lastname: Cooke
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Wilson
mesh_terms: D050197:Atherosclerosis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D016491:Peripheral Vascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D040901:Proteomics; D012307:Risk Factors
chemical_list: D015415:Biomarkers
references.citation: N Engl J Med. 2004 Dec 30;351(27):2817-26
references.pmid: 15591335
references.citation: Atherosclerosis. 2005 Sep;182(1):175-80
references.pmid: 16115489
references.citation: Vasc Med. 2005 Aug;10(3):191-8
references.pmid: 16235772
references.citation: Diabetes Care. 2003 Dec;26(12):3333-41
references.pmid: 14633825
references.citation: Atherosclerosis. 2004 Jul;175(1):131-8
references.pmid: 15186957
references.citation: N Engl J Med. 2001 May 24;344(21):1608-21
references.pmid: 11372014
references.citation: J Am Geriatr Soc. 1997 Dec;45(12):1472-8
references.pmid: 9400557
references.citation: Ann Intern Med. 2008 Jan 15;148(2):85-93
references.pmid: 18195333
references.citation: Circ Res. 2006 Feb 3;98(2):200-8
references.pmid: 16373601
references.citation: Vasc Med. 2006 Feb;11(1):21-8
references.pmid: 16669409
references.citation: Am Heart J. 2005 Aug;150(2):276-81
references.pmid: 16086930
references.citation: J Clin Epidemiol. 1992 Oct;45(10):1101-9
references.pmid: 1474406
references.citation: Mayo Clin Proc. 1987 Jul;62(7):601-6
references.pmid: 3473272
references.citation: JAMA. 2008 Jul 9;300(2):197-208
references.pmid: 18612117
references.citation: Circulation. 1999 Mar 9;99(9):1141-6
references.pmid: 10069780
references.citation: J Clin Pathol. 2006 Feb;59(2):211-5
references.pmid: 16443741
references.citation: Circulation. 1997 Apr 15;95(8):2068-74
references.pmid: 9133517
references.citation: Am J Cardiol. 2005 Sep 1;96(5):655-8
references.pmid: 16125489
references.citation: J Am Coll Cardiol. 2006 Sep 19;48(6):1190-7
references.pmid: 16979004
references.citation: Hypertens Res. 2006 Jan;29(1):23-8
references.pmid: 16715650
references.citation: J Pathol. 2000 Feb;190(3):255-66
references.pmid: 10685060
references.citation: Arch Intern Med. 2008 Jan 28;168(2):200-6
references.pmid: 18227369
references.citation: Immunity. 2002 Jan;16(1):1-4
references.pmid: 11825560
references.citation: Circulation. 2005 Aug 16;112(7):976-83
references.pmid: 16087797
references.citation: Curr Med Chem. 2005;12(4):443-52
references.pmid: 15720252
references.citation: Circulation. 2006 Mar 21;113(11):e463-654
references.pmid: 16549646
references.citation: Circulation. 2004 Apr 13;109(14):1697-703
references.pmid: 15078805
references.citation: J Intern Med. 2005 Sep;258(3):238-43
references.pmid: 16115297
references.citation: J Am Coll Cardiol. 2006 Mar 21;47(6):1182-7
references.pmid: 16545650
references.citation: Atherosclerosis. 2009 Apr;203(2):509-14
references.pmid: 18701106
references.citation: J Clin Endocrinol Metab. 1999 Jul;84(7):2425-8
references.pmid: 10404815
references.citation: Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):538-45
references.pmid: 10073955
references.citation: Lancet. 2001 Oct 13;358(9289):1257-64
references.pmid: 11675083
references.citation: Circulation. 2007 Oct 30;116(18):2086-94
references.pmid: 17875966
references.citation: Vasc Med. 2006 Feb;11(1):55-60
references.pmid: 16669416
references.citation: Br J Haematol. 1999 Jun;105(3):648-54
references.pmid: 10354125
references.citation: Mayo Clin Proc. 2005 Apr;80(4):494-8
references.pmid: 15819286
references.citation: Vasc Med. 2006 Feb;11(1):39-47
references.pmid: 16669412
references.citation: Clin Chim Acta. 2007 Jun;381(2):119-23
references.pmid: 17442291
references.citation: Vasc Med. 2008 Aug;13(3):217-24
references.pmid: 18687758
references.citation: Mol Cell Proteomics. 2004 Apr;3(4):311-26
references.pmid: 14718574
references.citation: Cleve Clin J Med. 2006 Oct;73 Suppl 4:S30-7
references.pmid: 17385389
references.citation: JAMA. 2001 Oct 3;286(13):1599-606
references.pmid: 11585483
references.citation: Atherosclerosis. 2005 Dec;183(2):301-7
references.pmid: 16285993
references.citation: J Intern Med. 2005 Jan;257(1):110-6
references.pmid: 15606382
references.citation: J Am Coll Cardiol. 2008 Jul 29;52(5):387-93
references.pmid: 18652948
references.citation: Circulation. 1985 Mar;71(3):510-5
references.pmid: 3156006
references.citation: Atherosclerosis. 1991 Apr;87(2-3):119-28
references.pmid: 1854359
references.citation: Circulation. 2006 Aug 22;114(8):861-6
references.pmid: 16923770
references.citation: Circulation. 1998 Feb 10;97(5):425-8
references.pmid: 9490235
references.citation: Curr Atheroscler Rep. 2006 Jan;8(1):55-61
references.pmid: 16455015
references.citation: Clin Chem Lab Med. 2004 May;42(5):475-86
references.pmid: 15202782
references.citation: Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):244-9
references.pmid: 9484989
references.citation: JAMA. 2004 Jul 28;292(4):453-61
references.pmid: 15280343
references.citation: Proteomics. 2005 Aug;5(13):3531-6
references.pmid: 16041672
references.citation: Atherosclerosis. 1999 Jul;145(1):51-60
references.pmid: 10428295
references.citation: Curr Opin Lipidol. 2006 Oct;17(5):502-9
references.pmid: 16960498
references.citation: Eur Heart J. 2007 Mar;28(5):608-12
references.pmid: 17298965
references.citation: Int J Epidemiol. 1988 Jun;17(2):248-54
references.pmid: 3042648
references.citation: Vasc Med. 2007 Nov;12(4):299-309
references.pmid: 18048466
references.citation: J Am Coll Cardiol. 2006 Jun 6;47(11):2219-28
references.pmid: 16750687
references.citation: Circulation. 2007 Sep 18;116(12):1396-403
references.pmid: 17724262
references.citation: Circulation. 2005 Oct 25;112(17):2703-7
references.pmid: 16246968
references.citation: Atherosclerosis. 1996 Apr 26;122(1):11-9
references.pmid: 8724107
references.citation: Physiol Genomics. 2003 May 13;13(3):249-62
references.pmid: 12644598
references.citation: Ultrasound Med Biol. 1996;22(4):391-8
references.pmid: 8795165
references.citation: JAMA. 2006 Feb 1;295(5):547-53
references.pmid: 16449620
references.citation: J Vasc Surg. 2004 Oct;40(4):768-73
references.pmid: 15472607
references.citation: Thromb Res. 1993 Sep 15;71(6):423-31
references.pmid: 8134903
references.citation: Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2536-40
references.pmid: 16931791
references.citation: Vasc Med. 2005 May;10(2):91-6
references.pmid: 16013192
references.citation: Circulation. 2002 Mar 5;105(9):1135-43
references.pmid: 11877368
references.citation: Clin Chem. 1995 Jan;41(1):173-6
references.pmid: 7813076
references.citation: J Surg Res. 2003 May 15;111(2):215-21
references.pmid: 12850465
references.citation: Vasc Med. 2001;6(3 Suppl):3-7
references.pmid: 11789963
references.citation: N Engl J Med. 1992 Feb 6;326(6):381-6
references.pmid: 1729621
references.citation: J Vasc Surg. 2005 Aug;42(2):243-51
references.pmid: 16102622
references.citation: JAMA. 2001 Sep 19;286(11):1317-24
references.pmid: 11560536
references.citation: BMJ. 1996 Dec 7;313(7070):1440-4
references.pmid: 8973232
references.citation: Vasc Med. 1998;3(3):241-5
references.pmid: 9892517
references.citation: Circulation. 1985 Mar;71(3):516-22
references.pmid: 3156007
references.citation: Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):2010-6
references.pmid: 12482827
references.citation: Nature. 2008 Feb 21;451(7181):949-52
references.pmid: 18288185
references.citation: Proteomics. 2005 Aug;5(13):3520-30
references.pmid: 16052623
references.citation: Atherosclerosis. 2006 Nov;189(1):236-40
references.pmid: 16414052
references.citation: J Cardiovasc Pharmacol. 1985;7 Suppl 3:S12-23
references.pmid: 2409385
references.citation: N Engl J Med. 2006 Dec 21;355(25):2631-9
references.pmid: 17182988