title: Brain malformation in single median maxillary central incisor.
abstract: Clinical and radiographic examinations and MR scan of a 12-year-old girl with SMMCI (single median maxillary central incisor) showed impaired growth and a midline defect involving the central incisor, cranium and the midline structures in the brain, falx cerebri and pituitary gland. She had a severe growth hormone deficiency but no other pituitary hormone deficiencies. She was treated with growth hormone and followed during a four-year period with successful gain in body height and sexual maturation. This study focuses on the developmental association between the involved structures and provides guidelines for early diagnostics.
authors.affiliation: Department of Orthodontics, Copenhagen School of Dentistry, Copenhagen, Denmark. ik@odont.ku.dk
authors.forename: I
authors.initials: I
authors.lastname: Kjaer
authors.forename: Aa
authors.initials: A
authors.lastname: Wagner
authors.forename: L L
authors.initials: LL
authors.lastname: Thomsen
authors.forename: K
authors.initials: K
authors.lastname: Holm
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007569:Jaw Abnormalities / Q000150:complications* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D009421:Nervous System Malformations / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D011862:Radiography, Panoramic; D014071:Tooth Abnormalities / Q000150:complications* / Q000601:surgery