title: Sonication-assisted synthesis of polyelectrolyte-coated curcumin nanoparticles.
abstract: A new method of nanoparticle formulation for poorly water-soluble materials was demonstrated for curcumin. The drug was dissolved in organic solvent that is miscible with water (ethanol), and drug nucleation was initiated by gradual worsening of the solution by the addition of an aqueous polyelectrolyte assisted by ultrasonication. Curcumin crystals of 60-100 nm size were obtained depending on the component concentrations, sonication power, and initial solvent. Layer-by-layer shell assembly with biocompatible polyelectrolytes was used to provide a particle coating with a high surface potential and the stabilization of drug nanocolloids. Polyelectrolyte layer-by-layer encapsulation allowed sustained drug release from nanoparticles over the range of 10-20 h.
authors.affiliation: Institute for Micromanufacturing, Chemistry Department, Louisiana Tech University, Ruston, Louisiana 71272, USA.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zheng
authors.forename: Xingcai
authors.initials: X
authors.lastname: Zhang
authors.forename: Daniel
authors.initials: D
authors.lastname: Carbo
authors.forename: Cheryl
authors.initials: C
authors.lastname: Clark
authors.forename: Cherie-Ann
authors.initials: C
authors.lastname: Nathan
authors.forename: Yuri
authors.initials: Y
authors.lastname: Lvov
mesh_terms: D003474:Curcumin / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D014465:Ultrasonics; D014961:X-Ray Diffraction
chemical_list: D004573:Electrolytes; D003474:Curcumin
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