Healing of displaced condylar process fracture in rats submitted to protein undernutrition.
BACKGROUND
This study evaluated the healing of mandibular condylar fracture in rats submitted to experimental and protein undernutrition (8% of protein) by means of histological analysis.


METHODS
Forty-five adult Wistar rats were divided into three groups of 15 animals: a fracture group, who were submitted to condylar fracture with no changes in diet; an undernourished fracture group, who were submitted to a low protein diet and condylar fracture: an undernourished group, kept until the end of experiment, without condylar fracture. Displaced fractures of the right condyle were created under general anaesthesia. The histological study comprised fracture site and temporomandibular joint evaluations.


RESULTS
The undernourished fracture group showed significant weight loss. There was a marked decrease in the values of serum proteins and albumin in the undernourished fracture group. Histological analysis showed that protein undernutrition lead to atrophy of the condylar fibrocartilage. Fractures in undernutrition presented a delay in callus formation due to more extensive devitalized bone areas, and after 3 months there were still bone formation areas, while fibrous ankylosis occurred in the articular space.


CONCLUSIONS
It was concluded that mandibular condyle fractures in rats with protein undernutrition had impaired callus formation, as well as fibrous ankylosis into the temporomandibular joint.
Rodrigues
Lucimar
L
Department of Oral and Maxillofacial Surgery, University of São Paulo, São Paulo, Brazil.
Corrêa
Luciana
L
Luz
João Gualberto C
JG
D000818:Animals; D000844:Ankylosis / Q000209:etiology; D001284:Atrophy; D001798:Blood Proteins / Q000032:analysis; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000209:etiology; D002146:Bony Callus / Q000503:physiopathology; D002358:Cartilage, Articular / Q000473:pathology; D051445:Fibrocartilage / Q000473:pathology; D005355:Fibrosis; D017102:Fracture Healing / Q000502:physiology*; D004204:Joint Dislocations / Q000503:physiopathology; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000503:physiopathology*; D008335:Mandibular Condyle / Q000293:injuries*; D008337:Mandibular Fractures / Q000503:physiopathology*; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D011488:Protein Deficiency / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013704:Temporomandibular Joint / Q000293:injuries / Q000503:physiopathology; D013705:Temporomandibular Joint Disorders / Q000209:etiology; D015431:Weight Loss / Q000502:physiology
D001798:Blood Proteins