Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006).
Tuberculosis and intestinal parasites affect primarily low social and economic level populations, living clustered in precarious habitational settings. One of the interesting aspects of this interaction is the parasitism influence in cellular response to tuberculosis. In the present study, we evaluated the prevalence of enteroparasitosis in tuberculosis patients, HIV-infected and non HIV infected, and we observed the influence of helminth presence in the response to tuberculin skin test (TST) and tuberculosis clinical outcomes. From 607 clinical records reviewed, 327 individuals met the study inclusion criteria and did not present any exclusion criteria. The prevalence of enteroparasites observed was 19.6%. There was no significant association among TST result and the variables related to the presence of: helminthes, protozoa, and stool test for parasites result (p>0.5). Considering the survival of this cohort, we may observe that there is no significant difference (p>0.05) between the survival curves of parasited and non parasited individuals. Solely the variable "eosinophils" presents a statistically significant association (p<0.001) with helminthes, all other associations are considered not significant. Our findings neither show an association between helminthic infection and a favorable tuberculosis outcome, nor between parasitism and TST response, unlike other in vitro studies. Apparently, experimental data do not correspond to the clinical findings.
Neto
Luanda M S
LM
Laboratório de Parasitologia, Instituto de Pesquisa Clínica Evandro Chagas (IPEC) - Fiocruz, Rio de Janeiro, RJ, Brazil.
Oliveira
Raquel de Vasconcellos Carvalhaes de
Rde V
Totino
Paulo Renato
PR
Sant'Anna
Flavia Marinho
FM
Coelho
Viviane de Oliveira
Vde O
Rolla
Valeria Cavalcanti
VC
Zanini
Graziela Maria
GM
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000401:mortality; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006373:Helminthiasis / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000453:epidemiology / Q000401:mortality; D015995:Prevalence; D011528:Protozoan Infections / Q000453:epidemiology* / Q000401:mortality; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000401:mortality