title: Pituitary hyperplasia in children with short stature and primary hypothyroidism.
abstract: We present eight cases with short stature, pituitary hyperplasia, and hypothyroidism. Pituitary hyperplasia due to primary hypothyroidism was diagnosed on the basis of clinical manifestations, endocrine examination and MRI. After 2 to 6 months of L-thyroxine replacement therapy, the signs of hypothyroidism disappeared; free triiodothyronine, free thyroxine, thyrotropin and prolactin became normal; and pituitary enlargement regressed. In two children, the growth rate remained low when treated with L-thyroxine, but with additional recombinant human growth hormone (rhGH), the height increased by 11 cm per year. No recurrence of lesions was found on follow-up.
authors.affiliation: Department of Pediatrics, The Affiliated Hospital of QingDao Medical College, QingDao University, QingDao 266 003, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Aijing
authors.forename: Li
authors.initials: L
authors.lastname: Tang
mesh_terms: D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D006965:Hyperplasia; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D010902:Pituitary Gland / Q000473:pathology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D019382:Human Growth Hormone; D013974:Thyroxine