title: Hepatitis B and Renal Disease.
abstract: Glomerulonephritis is an important extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The uncommon occurrence, variability in renal histopathology, and heterogeneity in clinical course present challenges in clinical studies and have resulted in a relative paucity of data and uncertainty with regard to the optimal management of HBV-related glomerular diseases. The advent of nucleos(t)ide analogue medications that effectively suppress HBV replication has markedly altered the clinical outcomes of kidney transplant recipients with HBV infection, but the emergence of drug resistance is an escalating problem. This article reviews the recent knowledge of the pathogenesis and treatment of HBV-related membranous nephropathy, and discusses the management of hepatitis B in kidney transplant recipients, which is continuously evolving.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
authors.forename: Tak Mao
authors.initials: TM
authors.lastname: Chan
references.citation: Ann Intern Med. 1989 Sep 15;111(6):479-83
references.pmid: 2774373
references.citation: Hepatology. 2001 Sep;34(3):590-4
references.pmid: 11526547
references.citation: Semin Dial. 2005 Jan-Feb;18(1):52-61
references.pmid: 15663766
references.citation: Clin Exp Nephrol. 2005 Sep;9(3):183-91
references.pmid: 16189625
references.citation: J Gastroenterol Hepatol. 2010 Jan;25(1):101-6
references.pmid: 19817965
references.citation: Rheumatol Int. 2009 Sep;29(11):1273-7
references.pmid: 19159933
references.citation: Gastroenterology. 1995 Aug;109(2):540-6
references.pmid: 7615204
references.citation: Clin Ther. 2006 Sep;28(9):1327-34
references.pmid: 17062306
references.citation: Am J Kidney Dis. 2008 Oct;52(4):691-8
references.pmid: 18805348
references.citation: Arch Dis Child. 2003 May;88(5):460
references.pmid: 12716731
references.citation: N Engl J Med. 1991 May 23;324(21):1457-63
references.pmid: 2023605
references.citation: Transplantation. 2001 Feb 15;71(3):387-94
references.pmid: 11233898
references.citation: World J Gastroenterol. 2006 Mar 21;12(11):1752-6
references.pmid: 16586546
references.citation: Arch Dis Child. 2003 May;88(5):446-9
references.pmid: 12716723
references.citation: Hepatology. 2002 Nov;36(5):1246-52
references.pmid: 12395336
references.citation: Pediatr Nephrol. 1998 Aug;12(6):479-84
references.pmid: 9745873
references.citation: Am J Transplant. 2004 Jul;4(7):1103-9
references.pmid: 15196068
references.citation: Clin J Am Soc Nephrol. 2007 May;2(3):563-75
references.pmid: 17699464
references.citation: Hepatology. 2004 Nov;40(5):1072-7
references.pmid: 15486926
references.citation: Kidney Int Suppl. 1991 Dec;35:S24-33
references.pmid: 1770708
references.citation: Kidney Int. 2005 Oct;68(4):1750-8
references.pmid: 16164651
references.citation: Transplantation. 1996 Jul 27;62(2):297-9
references.pmid: 8755832
references.citation: J Hepatol. 1989 May;8(3):367-72
references.pmid: 2471723
references.citation: J Viral Hepat. 2003 Jul;10(4):298-305
references.pmid: 12823597
references.citation: Hepatology. 2007 Feb;45(2):507-39
references.pmid: 17256718
references.citation: J Med Virol. 2007 Sep;79(9):1305-11
references.pmid: 17607789
references.citation: Am J Nephrol. 1997;17(2):112-7
references.pmid: 9096440
references.citation: Nephrol Dial Transplant. 2009 May;24(5):1598-603
references.pmid: 19096083
references.citation: Nephron. 1990;55(1):37-44
references.pmid: 2191232
references.citation: JAMA. 2006 Jan 4;295(1):65-73
references.pmid: 16391218
references.citation: Clin Exp Nephrol. 2009 Aug;13(4):373-377
references.pmid: 19169768
references.citation: Kidney Int. 1995 Jan;47(1):225-30
references.pmid: 7731150
references.citation: Tissue Antigens. 2003 Dec;62(6):505-11
references.pmid: 14617034
references.citation: Kidney Int. 1999 May;55(5):1763-75
references.pmid: 10231439
references.citation: Transplantation. 1991 Feb;51(2):391-6
references.pmid: 1994533
references.citation: Pediatr Nephrol. 1994 Feb;8(1):11-4
references.pmid: 8142208
references.citation: Clin Nephrol. 2006 Jan;65(1):53-6
references.pmid: 16429843
references.citation: Gastroenterology. 1987 Feb;92(2):524-6
references.pmid: 3792787
references.citation: Hepatology. 1999 Jan;29(1):257-63
references.pmid: 9862875
references.citation: Hepatology. 1985 Mar-Apr;5(2):317-20
references.pmid: 3979964
references.citation: J Med Virol. 2006 May;78(5):551-60
references.pmid: 16555286
references.citation: Clin Transplant. 2010 Mar-Apr;24(2):207-12
references.pmid: 19758269
references.citation: BMJ. 1988 Aug 20-27;297(6647):522-3
references.pmid: 3139182
references.citation: Hepatology. 2009 May;49(5 Suppl):S129-37
references.pmid: 19399799
references.citation: Int J Infect Dis. 2009 May;13(3):394-8
references.pmid: 19036623
references.citation: Pediatr Nephrol. 1992 Sep;6(5):417-20
references.pmid: 1280987
references.citation: Am J Transplant. 2009 Aug;9(8):1853-8
references.pmid: 19538486
references.citation: J Med Virol. 2007 Nov;79(11):1655-63
references.pmid: 17854044
references.citation: Kidney Int Suppl. 1991 Dec;35:S34-9
references.pmid: 1837572
references.citation: Clin Infect Dis. 2003 Apr 15;36(8):1070-3
references.pmid: 12684922