title: Cystatin C, a novel urinary biomarker for sensitive detection of acute kidney injury during haemorrhagic fever with renal syndrome.
abstract: To explore the value of cystatin C for evaluating acute kidney injury (AKI) in haemorrhagic fever with renal syndrome (HFRS), the concentrations of cystatin C in serum and urine samples from HFRS patients were determined. The serum and urinary cystatin C concentrations significantly increased in HFRS patients compared with normal controls (p < 0.001). In the acute phase of HFRS, urinary cystatin C increased to higher levels than serum creatinine, especially in severe or critical cases in the oliguric stage. Furthermore, higher levels of urinary cystatin C in the acute phase positively correlated with increased severity of the subsequent kidney injury. In conclusion, urinary cystatin C is a more sensitive clinical marker for AKI in HFRS, which may enable us to initiate treatment measures as early as possible.
authors.affiliation: Department of Immunology, The Fourth Military Medical University, Xi'an, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Jiuping
authors.initials: J
authors.lastname: Wang
authors.forename: Zhuwei
authors.initials: Z
authors.lastname: Xu
authors.forename: Chaojun
authors.initials: C
authors.lastname: Song
authors.forename: Ran
authors.initials: R
authors.lastname: Zhuang
authors.forename: Kun
authors.initials: K
authors.lastname: Yang
authors.forename: Angang
authors.initials: A
authors.lastname: Yang
authors.forename: Boquan
authors.initials: B
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine*; D002648:Child; D055316:Cystatin C / Q000097:blood / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000150:complications* / Q000652:urine; D006482:Hemorrhagic Fevers, Viral / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055316:Cystatin C