title: Aminoheterocycles as synthons for combinatorial Biginelli reactions.
abstract: Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.
authors.affiliation: Enamine Ltd, 23 A. Matrosova St., Kyiv, 01103, Ukraine. Ryabukhin@mail.enamine.net
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Ryabukhin
authors.forename: Andrey S
authors.initials: AS
authors.lastname: Plaskon
authors.forename: Sergey Yu
authors.initials: SY
authors.lastname: Boron
authors.forename: Dmitriy M
authors.initials: DM
authors.lastname: Volochnyuk
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tolmachev
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries
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