title: Fast repair of DNA radicals.
abstract: This tutorial review highlights the mechanism of a novel non-enzymatic fast repair of DNA damage, which refers exclusively to repair DNA radicals including DNA-OH* adducts, DNA radical cations and anions by various endogenous, natural and synthetic compounds. The repair rate constants are as high as 10(9) M(-1) s(-1). In cells, when the enzymatic repair system was inhibited or before the enzymatic repair mechanism was initiated, DNA oxidative damage was significantly reduced by natural polyphenols. This decrease of DNA damage is assigned to the fast repair. Fast repair takes place through an electron transfer process, and docking of polyphenol into the DNA minor groove could be the essential step.
authors.affiliation: School of Life Sciences, Lanzhou University, Lanzhou, 730000, China. zhengrl@lzu.edu.cn
authors.forename: Rongliang
authors.initials: R
authors.lastname: Zheng
authors.forename: Yimin
authors.initials: Y
authors.lastname: Shi
authors.forename: Zhongjian
authors.initials: Z
authors.lastname: Jia
authors.forename: Chenyang
authors.initials: C
authors.lastname: Zhao
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Tan
mesh_terms: D002477:Cells / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry* / Q000378:metabolism*; D004260:DNA Repair; D004579:Electron Transport; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D013997:Time Factors
chemical_list: D018736:DNA Adducts; D005609:Free Radicals