title: SF1 and SF2 helicases: family matters.
abstract: Helicases of the superfamily (SF) 1 and 2 are involved in virtually all aspects of RNA and DNA metabolism. SF1 and SF2 helicases share a catalytic core with high structural similarity, but different enzymes even within each SF perform a wide spectrum of distinct functions on diverse substrates. To rationalize similarities and differences between these helicases, we outline a classification based on protein families that are characterized by typical sequence, structural, and mechanistic features. This classification complements and extends existing SF1 and SF2 helicase categorizations and highlights major structural and functional themes for these proteins. We discuss recent data in the context of this unifying view of SF1 and SF2 helicases.
authors.affiliation: Center for RNA Molecular Biology & Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Fairman-Williams
authors.forename: Ulf-Peter
authors.initials: UP
authors.lastname: Guenther
authors.forename: Eckhard
authors.initials: E
authors.lastname: Jankowsky
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004265:DNA Helicases / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D020365:RNA Helicases / Q000737:chemistry / Q000145:classification / Q000378:metabolism
chemical_list: D004265:DNA Helicases; D020365:RNA Helicases
references.citation: Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16698-703
references.pmid: 17075070
references.citation: J Biol Chem. 2009 Nov 6;284(45):30845-52
references.pmid: 19759018
references.citation: Nat Struct Mol Biol. 2009 Jul;16(7):731-9
references.pmid: 19525970
references.citation: Nat Rev Mol Cell Biol. 2008 May;9(5):391-401
references.pmid: 18414490
references.citation: J Mol Biol. 2010 Mar 5;396(4):949-66
references.pmid: 20026132
references.citation: Biochemistry. 2004 Jun 22;43(24):7857-66
references.pmid: 15196029
references.citation: EMBO J. 2000 Jul 17;19(14):3799-810
references.pmid: 10899133
references.citation: Nucleic Acids Res. 2009 Feb;37(2):421-30
references.pmid: 19050012
references.citation: Nature. 2001 Jan 18;409(6818):363-6
references.pmid: 11201747
references.citation: PLoS Biol. 2008 Jun 24;6(6):e149
references.pmid: 18578568
references.citation: Mol Biol Evol. 2001 Mar;18(3):330-43
references.pmid: 11230534
references.citation: Nucleic Acids Res. 2008 May;36(9):3139-49
references.pmid: 18411208
references.citation: Mol Cell. 2007 Oct 26;28(2):253-63
references.pmid: 17964264
references.citation: Curr Pharm Des. 2006;12(11):1315-38
references.pmid: 16611118
references.citation: J Mol Biol. 2002 Mar 15;317(1):41-72
references.pmid: 11916378
references.citation: EMBO J. 2008 May 7;27(9):1388-98
references.pmid: 18388857
references.citation: Cell. 2005 May 6;121(3):363-73
references.pmid: 15882619
references.citation: Nat Rev Cancer. 2009 Sep;9(9):644-54
references.pmid: 19657341
references.citation: Immunity. 2009 Jul 17;31(1):25-34
references.pmid: 19576794
references.citation: Nat Struct Mol Biol. 2006 Nov;13(11):981-6
references.pmid: 17072313
references.citation: Nucleic Acids Res. 2006;34(15):4181-8
references.pmid: 16935886
references.citation: RNA. 2009 Dec;15(12):2083-104
references.pmid: 19850913
references.citation: J Biol Chem. 2005 Mar 4;280(9):7854-60
references.pmid: 15634678
references.citation: Nucleic Acids Res. 2003 Jun 1;31(11):2778-85
references.pmid: 12771204
references.citation: Cell Mol Life Sci. 2007 Sep;64(17):2306-22
references.pmid: 17571213
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12067-72
references.pmid: 19574455
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1039-44
references.pmid: 19151156
references.citation: J Biol Chem. 2005 Oct 21;280(42):35499-505
references.pmid: 16118224
references.citation: Annu Rev Biophys. 2008;37:317-36
references.pmid: 18573084
references.citation: EMBO J. 2007 Jan 10;26(1):253-64
references.pmid: 17159905
references.citation: Mol Cell. 2008 Jun 20;30(6):743-54
references.pmid: 18570877
references.citation: Structure. 1999 Nov 15;7(11):1353-63
references.pmid: 10574797
references.citation: Cell. 2006 Apr 21;125(2):287-300
references.pmid: 16630817
references.citation: Cell. 1999 Apr 2;97(1):75-84
references.pmid: 10199404
references.citation: EMBO J. 2008 Aug 20;27(16):2222-9
references.pmid: 18668125
references.citation: Nucleic Acids Res. 1999 Aug 15;27(16):3310-7
references.pmid: 10454638
references.citation: Acta Biochim Biophys Sin (Shanghai). 2004 Mar;36(3):177-83
references.pmid: 15202501
references.citation: J Biol Chem. 1998 Aug 14;273(33):21161-8
references.pmid: 9694872
references.citation: Nat Struct Mol Biol. 2006 Nov;13(11):954-5
references.pmid: 17082789
references.citation: Mol Cell. 2009 Nov 25;36(4):583-92
references.pmid: 19941819
references.citation: HFSP J. 2009 Jun;3(3):153-64
references.pmid: 19949442
references.citation: Nucleic Acids Res. 2006;34(15):4168-80
references.pmid: 16936318
references.citation: Mol Cell Biol. 2008 May;28(10):3359-71
references.pmid: 18332124
references.citation: Hum Mol Genet. 2009 Apr 1;18(7):1288-300
references.pmid: 19158098
references.citation: EMBO J. 2002 Mar 1;21(5):1168-76
references.pmid: 11867545
references.citation: J Biol Chem. 2010 Apr 9;285(15):11692-703
references.pmid: 20110368
references.citation: Trends Plant Sci. 2009 Jun;14(6):344-52
references.pmid: 19446493
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20209-14
references.pmid: 19088201
references.citation: Cell. 2008 May 30;133(5):801-12
references.pmid: 18510925
references.citation: Science. 2007 Jul 27;317(5837):513-6
references.pmid: 17656723
references.citation: Cell. 2009 May 29;137(5):849-59
references.pmid: 19490894
references.citation: Nat Struct Mol Biol. 2009 Jan;16(1):94-5
references.pmid: 19079266
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10076-81
references.pmid: 16009938
references.citation: Biochim Biophys Acta. 2004 Jul 6;1704(1):37-46
references.pmid: 15238243
references.citation: J Virol. 1997 Apr;71(4):2583-90
references.pmid: 9060609
references.citation: Structure. 1998 Jan 15;6(1):89-100
references.pmid: 9493270
references.citation: Genome Res. 2004 Jun;14(6):1188-90
references.pmid: 15173120
references.citation: Mol Cell. 2008 Feb 1;29(2):169-79
references.pmid: 18243112
references.citation: J Biol Chem. 2010 Mar 5;285(10):6922-36
references.pmid: 20048388
references.citation: Mol Cell. 2008 Feb 29;29(4):428-40
references.pmid: 18242112
references.citation: Nat Struct Mol Biol. 2007 Jul;14(7):647-52
references.pmid: 17558417
references.citation: Nucleic Acids Res. 2001 Jan 15;29(2):565-72
references.pmid: 11139627
references.citation: Nucleic Acids Res. 2006;34(15):4160-7
references.pmid: 16935875
references.citation: EMBO J. 2009 Aug 5;28(15):2293-306
references.pmid: 19556969
references.citation: Nucleic Acids Res. 2009 Oct;37(19):6540-9
references.pmid: 19734346
references.citation: Cell. 2001 Oct 5;107(1):79-89
references.pmid: 11595187
references.citation: Curr Opin Struct Biol. 2007 Jun;17(3):316-24
references.pmid: 17574830
references.citation: Science. 2009 Feb 20;323(5917):1070-4
references.pmid: 19119185
references.citation: Mol Cell. 2009 Sep 11;35(5):598-609
references.pmid: 19748356
references.citation: Science. 2006 Sep 29;313(5795):1968-72
references.pmid: 16931718
references.citation: Cell. 2006 Aug 25;126(4):713-25
references.pmid: 16923391
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17040-5
references.pmid: 18971330
references.citation: Curr Opin Struct Biol. 2010 Feb;20(1):121-7
references.pmid: 20061135
references.citation: Nucleic Acids Res. 2002 Apr 1;30(7):1427-64
references.pmid: 11917006
references.citation: Immunity. 2008 Aug 15;29(2):178-81
references.pmid: 18701081
references.citation: Mol Cell. 2009 Aug 28;35(4):454-66
references.pmid: 19716790
references.citation: Nat Struct Mol Biol. 2005 Apr;12(4):350-6
references.pmid: 15806108
references.citation: Biochemistry. 2006 May 23;45(20):6510-21
references.pmid: 16700561
references.citation: EMBO J. 2008 Dec 3;27(23):3209-19
references.pmid: 19008861
references.citation: Structure. 2008 Sep 10;16(9):1417-27
references.pmid: 18786404
references.citation: J Mol Biol. 2009 Feb 27;386(3):612-25
references.pmid: 19150358
references.citation: Eur J Biochem. 1976 Jun 1;65(2):441-9
references.pmid: 133023
references.citation: Cell. 2008 May 30;133(5):789-800
references.pmid: 18510924
references.citation: Mol Cell. 2003 Jan;11(1):127-38
references.pmid: 12535527
references.citation: Annu Rev Biochem. 2007;76:23-50
references.pmid: 17506634
references.citation: Nucleic Acids Res. 2009 Jul;37(13):4464-71
references.pmid: 19474341
references.citation: Gene. 2006 Feb 15;367:17-37
references.pmid: 16337753
references.citation: Trends Cell Biol. 2001 Feb;11(2):60-5
references.pmid: 11166213
references.citation: Structure. 2005 Jan;13(1):143-53
references.pmid: 15642269
references.citation: EMBO Rep. 2010 Mar;11(3):180-6
references.pmid: 20168331
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20203-8
references.pmid: 19088196
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):521-8
references.pmid: 20080715
references.citation: Nature. 2004 Nov 11;432(7014):187-93
references.pmid: 15538360
references.citation: J Mol Biol. 1999 Apr 30;288(2):255-74
references.pmid: 10329141
references.citation: Curr Opin Struct Biol. 2008 Feb;18(1):112-9
references.pmid: 18164611
references.citation: DNA Repair (Amst). 2010 Mar 2;9(3):202-9
references.pmid: 20097140
references.citation: Cell. 2006 Dec 29;127(7):1349-60
references.pmid: 17190599
references.citation: Nat Struct Mol Biol. 2008 Nov;15(11):1223-7
references.pmid: 18849995