Chemistry of the cortistatins--a novel class of anti-angiogenic agents.
Synthetic efforts culminating the construction of several highly advanced intermediates, and completed syntheses of the recently disclosed cortistatin family of anti-proliferative agents are described in this perspective.
Chen
David Yu-Kai
DY
Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667. david_chen@ices.a-star.edu.sg
Tseng
Chih-Chung
CC
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009479:Neuropeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D020533:Angiogenesis Inhibitors; D009479:Neuropeptides; C099323:cortistatin