title: Association between polymorphisms in the serotonin 2C receptor gene and premature ejaculation in Han Chinese subjects.
abstract: BACKGROUND
  Lifelong premature ejaculation (LPE) is characterized by persistently shorter intravaginal ejaculation latency time (IELT) than found acceptable by the patient or his partner. It has been postulated to be a neurobiological dysfunction with genetic vulnerability and is related to disturbances of central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and 5-HT receptor function.
  
  
  OBJECTIVE
  To investigate the relationship between the C-759T and G-697C polymorphisms of the 5-HT(2C) receptor and LPE.
  
  
  METHODS
  A prospective study was conducted in 106 Han Chinese men with LPE, characterized by IELT of less than 1 min, and 84 healthy controls with IELT of more than 3 min. All subjects were genotyped for the C-759T and G-697C polymorphisms located in the promoter region of the 5-HT(2C) receptor. The frequencies of genotypes and single nucleotide mutations were compared between the two groups.
  
  
  RESULTS
  Three genotypes were detected both in the men with LPE and in the control group: -759C/-697G, -759T/-697C, and -759C/ -697C. Genotype -759T/-697G was not detected. The frequency of genotype -759T/-697C was higher in patients with LPE than in the control group (30.2 vs. 11.9%, p < 0.05), whereas the frequency of genotype -759C/-697G was lower in patients with LPE than in the control group (66.0 vs. 83.3%, p < 0.05). No difference was found for genotype -759C/ -697C between the two groups. Mutations at -759T and -697C were more frequent in patients than in the control group (-759T: 30.2 vs. 13.3%, p < 0.05; -697C: 30.4 vs. 16.7%, p < 0.05, respectively).
  
  
  CONCLUSIONS
  Our findings indicated that polymorphisms in the 5-HT(2C) receptor gene are associated with LPE, and men who carry the -759T or -697C genotype have increased odds of premature ejaculation. Further investigation in this field is necessary.
authors.affiliation: Urological Department, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Shunwen
authors.initials: S
authors.lastname: Luo
authors.forename: Yiping
authors.initials: Y
authors.lastname: Lu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Xie
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dong
authors.forename: Sixiao
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D004542:Ejaculation / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D044405:Receptor, Serotonin, 5-HT2C