title: The thrombotic profile of treatment-naive HIV-positive Black South Africans with acute coronary syndromes.
abstract: BACKGROUND
  Patients with human immunodeficiency virus (HIV) infection on protease inhibitors (PIs) have a heightened risk of arterial thrombosis but little is known about treatment-naive patients.
  
  
  RESULTS
  Prospective study from South Africa comparing thrombotic profiles of HIV-positive and -negative patients with acute coronary syndrome (ACS). A total of 30 treatment-naive HIV-positive patients with ACS were compared to 30 HIV-negative patients with ACS. Patients with HIV were younger; and besides smoking (73% vs 33%) and low high-density lipoprotein (HDL; 0.8 ± 0.3 vs 1.1 ± 0.4), they had fewer risk factors. Thrombophilia was more common in HIV-positive patients with lower protein C (PC; 82 ± 22 vs 108 ± 20) and higher factor VIII levels (201 ± 87 vs 136 ± 45). Patients with HIV had higher frequencies of anticardiolipin (aCL; 47% vs 10%) and antiprothrombin antibodies (87% vs 21%).
  
  
  CONCLUSIONS
  Treatment-naive HIV-positive patients with ACS are younger, with fewer traditional risk factors but a greater degree of thrombophilia compared with HIV-negative patients.
authors.affiliation: Division of Cardiology, Chris Hani Baragwanath Hospital, Johannesburg, South Africa. abecker@worldonline.co.za
authors.forename: A C
authors.initials: AC
authors.lastname: Becker
authors.forename: B
authors.initials: B
authors.lastname: Jacobson
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: K
authors.initials: K
authors.lastname: Sliwa
authors.forename: S
authors.initials: S
authors.lastname: Stewart
authors.forename: E
authors.initials: E
authors.lastname: Libhaber
authors.forename: M R
authors.initials: MR
authors.lastname: Essop
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000209:etiology / Q000628:therapy; D000328:Adult; D000367:Age Factors; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D044383:Black People; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006679:HIV Seropositivity / Q000097:blood* / Q000150:complications / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011486:Protein C / Q000032:analysis*; D012307:Risk Factors; D013019:South Africa; D019851:Thrombophilia / Q000097:blood* / Q000209:etiology / Q000628:therapy
chemical_list: D017153:Antibodies, Anticardiolipin; D011486:Protein C; D005169:Factor VIII