title: [Androgen receptor CAG gene polymorphism in men with azoospermia and oligozoospermia in Ukraine].
abstract: The number of CAG repeats of exon 1 of AR gene was determined in a group of 228 infertile males with azoospermia (n = 68) and oligozoospermia (n = 160) as well as in control group (124 proven fathers) by fluorescent polymerase chain reaction amplification followed by fragment analysis on automated fluorescent analyzer "A.L.F-express". The frequency of alleles with GAG-repeats < or = 18 was significantly higher (P < 0,01) in the group of patients with azoospermia (17,7%) comparing with the control group (2,4%) as well as in the group of patients with oligozoospermia (12,5%) comparing with the control group (2,4%). The frequency of alleles with CAG-repeats > or = 28 significantly differed (P < 0,01) between the group of patients with oligozoospermia (12,5%) and the control group (2,4%). Our data suggest an association between CAG repeats number and impaired spermatogenesis in azoospermic and oligozoospermic males.
authors.forename: O A
authors.initials: OA
authors.lastname: Fesaĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Kravchenko
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Tyrkus
authors.forename: G V
authors.initials: GV
authors.lastname: Makukh
authors.forename: V M
authors.initials: VM
authors.lastname: Zinchenko
authors.forename: G V
authors.initials: GV
authors.lastname: Strelko
authors.forename: L A
authors.initials: LA
authors.lastname: Livshits
mesh_terms: D053713:Azoospermia / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D013091:Spermatogenesis / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics*; D014455:Ukraine
chemical_list: D011944:Receptors, Androgen