[Clinical characteristics and outcome comparison between young (< or = 45 years) female and male patients with coronary artery disease undergoing percutaneous coronary intervention].
OBJECTIVE
To compare the clinical characteristics and clinical outcomes in young (< / = 45 years) female and male coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI).


METHODS
Angiographic and clinical data from 124 premenopausal female patients who underwent elective PCI from April 2004 to February 2008 were compared to age-matched 430 male patients who underwent elective PCI between 2006 and 2007 in our department. All patients were treated according to guidelines and coronary angiography was repeated after 6 months. One year clinical follow-up were performed in all patients.


RESULTS
Incidences of dyslipidemia, the history of myocardial infarction and smoking were significantly lower in female patients than in male patients (all P < 0.01). Left main, left anterior descending and bifurcation lesions were more common while type C lesion and right coronary lesion were less common in young female CAD group compared to young male CAD group (P < 0.01-0.05). The average lesion length in female patients was significantly longer than that in male patients [(20.36 +/- 13.37) mm vs. (23.04 +/- 13.86) mm, P < 0.05]. The in-hospital and follow-up incidences of major adverse cardiac events, stent thrombosis and in-stent restenosis were similar between young female and male CAD patients.


CONCLUSIONS
CAD risk factors were less and vessel lesions were more likely to be found at left main, left anterior descending and bifurcation in young female CAD patients compared to young male CAD patients. The clinical outcomes were similar between young female and male CAD patients.
Huang
Jing-han
JH
Coronary Heart Disease Center, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China.
Qiao
Shu-bin
SB
Xu
Bo
B
Li
Jian-jun
JJ
Chen
Jue
J
Liu
Hai-bo
HB
Yang
Yue-jin
YJ
Yao
Min
M
Wu
Yong-jian
YJ
Yuan
Jin-qing
JQ
Qin
Xue-wen
XW
Wu
Yuan
Y
Dai
Jun
J
You
Shi-jie
SJ
Hu
Feng-huan
FH
Ma
Wei-hua
WH
Qian
Jie
J
Zhang
Pei
P
Dou
Ke-fei
KF
Chen
Ji-lin
JL
Chen
Zai-jia
ZJ
Gao
Run-lin
RL
D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome