8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.
Ahmadiyeh
Nasim
N
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02115, USA.
Pomerantz
Mark M
MM
Grisanzio
Chiara
C
Herman
Paula
P
Jia
Li
L
Almendro
Vanessa
V
He
Housheng Hansen
HH
Brown
Myles
M
Liu
X Shirley
XS
Davis
Matt
M
Caswell
Jennifer L
JL
Beckwith
Christine A
CA
Hills
Adam
A
Macconaill
Laura
L
Coetzee
Gerhard A
GA
Regan
Meredith M
MM
Freedman
Matthew L
ML
D001943:Breast Neoplasms / Q000235:genetics*; D045744:Cell Line, Tumor; D002898:Chromosomes, Human, Pair 8; D003110:Colonic Neoplasms / Q000235:genetics*; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D056426:Genetic Loci; D015894:Genome, Human; D006801:Humans; D009928:Organ Specificity; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012307:Risk Factors
C000715470:MAS1 protein, human; C489427:MYC protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc
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