Class II cytokine common receptors: something old, something new.
In this issue of Structure, Yoon and colleagues provide models of a low affinity cytokine common receptor, IL-10R2, in a ternary complex with two class II cytokines and their corresponding ligand-specific receptors, revealing the nature of their promiscuous interactions.
Hinck
Andrew P
AP
Department of Biochemistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. hinck@uthscsa.edu