title: Adult neurogenesis: integrating theories and separating functions.
abstract: The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Aimone
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D049109:Cell Proliferation; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
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