title: Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice.
abstract: BACKGROUND
  Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of prenatal environmental exposures on adult offspring have not been well-studied. We hypothesized that combined prenatal exposure to Aspergillus fumigatus (A. fumigatus) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring.
  
  
  METHODS
  Following sensitization via the airway route to A. fumigatus and mating, pregnant BALB/c mice were exposed to additional A. fumigatus and/or diesel exhaust particles. At age 9-10 weeks, their offspring were sensitized and challenged with A. fumigatus.
  
  
  RESULTS
  We found that adult offspring from mice that were exposed to A. fumigatus or diesel exhaust particles during pregnancy experienced decreases in IgE production. Adult offspring of mice that were exposed to both A. fumigatus and diesel exhaust particles during pregnancy experienced decreases in airway eosinophilia.
  
  
  CONCLUSIONS
  These results suggest that, in this model, allergen and/or diesel administration during pregnancy may be associated with protection from developing systemic and airway allergic immune responses in the adult offspring.
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. rlm14@columbia.edu
authors.forename: Lin
authors.initials: L
authors.lastname: Corson
authors.forename: Huaijie
authors.initials: H
authors.lastname: Zhu
authors.forename: Chunli
authors.initials: C
authors.lastname: Quan
authors.forename: Gabriele
authors.initials: G
authors.lastname: Grunig
authors.forename: Manisha
authors.initials: M
authors.lastname: Ballaney
authors.forename: Ximei
authors.initials: X
authors.lastname: Jin
authors.forename: Frederica P
authors.initials: FP
authors.lastname: Perera
authors.forename: Phillip H
authors.initials: PH
authors.lastname: Factor
authors.forename: Lung-Chi
authors.initials: LC
authors.lastname: Chen
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Miller
references.citation: Am J Respir Cell Mol Biol. 2002 Nov;27(5):526-35
references.pmid: 12397011
references.citation: Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2296-302
references.pmid: 19020316
references.citation: J Immunol. 1991 Feb 1;146(3):879-83
references.pmid: 1703184
references.citation: Toxicol Sci. 2008 Mar;102(1):76-81
references.pmid: 18042818
references.citation: Curr Opin Pediatr. 2009 Apr;21(2):235-42
references.pmid: 19663041
references.citation: Clin Exp Allergy. 2007 Dec;37(12):1827-32
references.pmid: 17919308
references.citation: Environ Health Perspect. 1997 Mar;105(3):302-6
references.pmid: 9171991
references.citation: Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L856-65
references.pmid: 16373670
references.citation: J Exp Med. 2008 Feb 18;205(2):361-72
references.pmid: 18227220
references.citation: Indoor Air. 2006 Dec;16(6):414-25
references.pmid: 17100663
references.citation: J Immunol. 2003 Feb 15;170(4):1683-9
references.pmid: 12574331
references.citation: Eur Respir J. 2008 Sep;32(3):603-11
references.pmid: 18448493
references.citation: Epidemiology. 2008 May;19(3):401-8
references.pmid: 18379426
references.citation: J Toxicol Environ Health A. 2007 Apr 15;70(8):688-95
references.pmid: 17365623
references.citation: Clin Exp Allergy. 2005 Oct;35(10):1251-3
references.pmid: 16238782
references.citation: Chest. 2004 Oct;126(4):1071-8
references.pmid: 15486366
references.citation: Eur Respir J. 2003 Aug;22(2):374-82
references.pmid: 12952276
references.citation: Nat Med. 2008 Feb;14(2):170-5
references.pmid: 18223654
references.citation: Clin Exp Allergy. 2005 Mar;35(3):397-402
references.pmid: 15784121
references.citation: Clin Exp Allergy. 2009 Sep;39(9):1381-9
references.pmid: 19489919
references.citation: Immunology. 2009 Sep;128(1 Suppl):e541-50
references.pmid: 19740315
references.citation: Int Arch Allergy Immunol. 2002 Mar;127(3):208-16
references.pmid: 11979046
references.citation: J Clin Invest. 2007 Jun;117(6):1637-46
references.pmid: 17549258
references.citation: Thorax. 1998 Oct;53(10):849-56
references.pmid: 10193371
references.citation: Eur Respir J. 2009 May;33(5):1133-40
references.pmid: 19129273
references.citation: J Immunol. 2007 Jul 15;179(2):1282-91
references.pmid: 17617621
references.citation: Acta Paediatr Suppl. 2006 Oct;95(453):93-105
references.pmid: 17000576
references.citation: J Clin Invest. 2008 Oct;118(10):3462-9
references.pmid: 18802477
references.citation: Immunology. 1983 Jan;48(1):49-58
references.pmid: 6848454
references.citation: J Allergy Clin Immunol. 2007 Apr;119(4):910-5
references.pmid: 17337296
references.citation: J Allergy Clin Immunol. 2006 Sep;118(3):666-73
references.pmid: 16950286
references.citation: Immunology. 2004 Jul;112(3):489-95
references.pmid: 15196218
references.citation: Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L109-14
references.pmid: 18931055
references.citation: Asian Pac J Allergy Immunol. 2008 Mar;26(1):11-7
references.pmid: 18595525
references.citation: Clin Exp Allergy. 2005 Oct;35(10):1272-8
references.pmid: 16238785
references.citation: Am J Respir Cell Mol Biol. 2008 Jan;38(1):57-67
references.pmid: 17656681
references.citation: Thorax. 2009 Apr;64(4):353-8
references.pmid: 19240083
references.citation: Am J Respir Cell Mol Biol. 2003 Sep;29(3 Pt 1):352-8
references.pmid: 12649123
references.citation: Respirology. 2009 Apr;14(3):360-70
references.pmid: 19207119
references.citation: J Immunol. 1999 May 15;162(10):6284-93
references.pmid: 10229876
references.citation: PLoS One. 2009;4(2):e4488
references.pmid: 19221603