Paraneoplastic pandysautonomia as a manifestation of non-small cell lung cancer.
Pandysautonomia is a severe and rare clinical condition characterized by widespread sympathetic and parasympathetic dysfunction. Consideration of whether symptoms and presentation are acute, subacute, or chronic is often helpful in establishing a differential diagnosis. The underlying mechanisms leading to pure pandysautonomia are unclear; however, there is some evidence suggestive of an immune-mediated pathogenesis. Herein, we report a case with pandysautonomia as a paraneoplastic manifestation of non-small cell lung cancer that had an excellent response to symptomatic and supportive treatments, as well as IVIG therapy.
Uluc
Kayihan
K
Department of Neurology, Marmara University Hospital, Tophanelioğlu cad. 13/15, Altunizade, Istanbul, Turkey. kayihanu@yahoo.com
Kocak
Muge
M
Koytak
Pinar Kahraman
PK
Borucu
Deniz
D
Isak
Baris
B
Aktan
Sevinc
S
Us
Onder
O
D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D054969:Primary Dysautonomias / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D011877:Radionuclide Imaging
D016756:Immunoglobulins, Intravenous
Ann Neurol. 2004 Nov;56(5):715-9
15468074
Lancet Neurol. 2008 Apr;7(4):327-40
18339348
Ann Neurol. 2003 Jun;53(6):752-8
12783421
Autoimmun Rev. 2007 Jan;6(3):162-8
17289552
J Neurol Neurosurg Psychiatry. 1997 May;62(5):529-31
9153616
Brain. 2004 Oct;127(Pt 10):2331-8
15361417
Lancet. 2005 Apr 2-8;365(9466):1259-70
15811460
Curr Opin Neurol. 2005 Oct;18(5):598-603
16155447
Eur J Neurol. 2006 Jul;13(7):682-90
16834698
Curr Opin Neurol. 1994 Oct;7(5):402-6
7804460
Neurology. 1998 Dec;51(6):1764-5
9855546
N Engl J Med. 1999 Jan 21;340(3):227-8
9895405
Arch Neurol. 2009 Jun;66(6):735-41
19506133
Lancet. 1996 Jan 6;347(8993):28-9
8531546
N Engl J Med. 2000 Sep 21;343(12):847-55
10995864
Muscle Nerve. 2003 Jun;27(6):646-61
12766975