title: A kidney tumor in an adolescent with severe hypertension and hypokalemia: an uncommon case--case report and review of the literature on reninoma.
abstract: This report presents a case of a 16-year-old hypertensive boy who presented to our clinic. Laboratory findings showed severe hypokalemia and markedly increased plasma renin activity. Abdominal ultrasonography and contrast-enhanced computed tomography of the abdomen revealed a well-circumscribed, solid, hypoenhancing cortical lesion (2 cm) in the lower pole of the left kidney. The patient underwent nephron-sparing surgery. Histopathologic examination gave a diagnosis of juxtaglomerular cell tumor. Reninoma is an uncommon cause of hypertension in a young adult and should be included in the differential diagnosis as a potential life-threatening and curable condition. The conservative surgical management is the gold standard for small, circumscribed lesions.
authors.affiliation: Centre for Reproductive Medicine and Andrology, University of Münster, Germany. Fedra.Gottardo @ ukmuenster.de
authors.forename: Fedra
authors.initials: F
authors.lastname: Gottardo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cesari
authors.forename: Aldo
authors.initials: A
authors.lastname: Morra
authors.forename: Marina
authors.initials: M
authors.lastname: Gardiman
authors.forename: Ambrogio
authors.initials: A
authors.lastname: Fassina
authors.forename: Massimo
authors.initials: M
authors.lastname: Dal Bianco
mesh_terms: D000293:Adolescent; D001706:Biopsy; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D007008:Hypokalemia / Q000097:blood / Q000209:etiology*; D007606:Juxtaglomerular Apparatus / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D007680:Kidney Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D012083:Renin / Q000097:blood*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D012083:Renin