Role of the renin-angiotensin system in age-related sarcopenia and diastolic dysfunction.
The purpose of this review is to describe how recent pharmacological and genetic studies have contributed to our understanding of the role of the renin-angiotensin system (RAS) in age-related sarcopenia and diastolic dysfunction. Treatment strategies are limited in the context of both of these conditions, although interventions, which include blockade of the RAS (using angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers) are successful and lead to improvements in functional outcomes that are not necessarily mediated by hemodynamic effects of the drugs. Studies in animal models of sarcopenia and diastolic dysfunction point to ubiquitous effects of RAS blockade on multiple biological mechanisms, including inflammation, oxidative damage and metabolic dysregulation. Therefore, a re-evaluation of the use of these drugs in other conditions should be considered for maintaining functional independence in older individuals.
Carter
Christy S
CS
University of Florida, Department of Aging & Geriatric Research, 1329 SW 16th Street, Room 5274, PO Box 100143, Gainesville, FL 32610-0143, USA, Tel.: +1 352 273 5727;
Groban
Leanne
L
J Am Soc Nephrol. 1994 Oct;5(4):1147-52
7849256
Circ Res. 1999 Apr 2;84(6):695-703
10189357
Hypertension. 2001 Oct;38(4):884-90
11641303
Am J Cardiol. 2003 May 22;91(10A):15G-21G
12781904
Diabetes Care. 2003 Feb;26(2):372-9
12547865
J Am Geriatr Soc. 2003 Mar;51(3):323-30
12588575
Mayo Clin Proc. 1988 Feb;63(2):137-46
3276974
Circ Res. 1993 Jun;72(6):1245-54
8495553
Lancet. 2002 Mar 16;359(9310):926-30
11918911
Free Radic Biol Med. 2007 Aug 15;43(4):477-503
17640558
Hypertension. 2001 Nov;38(5):1130-6
11711510
Arterioscler Thromb Vasc Biol. 2005 May;25(5):932-43
15731494
J Appl Physiol (1985). 2003 Feb;94(2):744-51
12391069
FASEB J. 2003 Jun;17(9):1096-8
12709417
Circ Res. 1999 Oct 1;85(7):643-50
10506489
Lancet. 1999 Feb 13;353(9152):541-5
10028982
J Immunol. 2003 Apr 1;170(7):3866-73
12646655
Arch Mal Coeur Vaiss. 2002 Mar;95(3):204-12
11998336
Arch Intern Med. 2000 Jan 10;160(1):53-60
10632305
Expert Opin Pharmacother. 2004 Jan;5(1):181-93
14680446
J Appl Physiol (1985). 2001 Jun;90(6):2157-65
11356778
Am J Epidemiol. 2002 Jul 15;156(2):110-21
12117699
N Engl J Med. 1996 Dec 19;335(25):1897-905
8948566
J Clin Invest. 1987 Jan;79(1):1-6
3025255
J Immunol. 2003 Jul 1;171(1):346-52
12817017
Circ Res. 1993 Sep;73(3):413-23
8348686
Am J Physiol. 1999 Dec;277(6):E1130-41
10600804
N Engl J Med. 2007 Aug 23;357(8):789-96
17715411
Diabetes. 1996 Jan;45 Suppl 1:S120-4
8529792
J Am Coll Cardiol. 2001 Feb;37(2):662-7
11216994
Nephron. 1990;55 Suppl 1:90-5
2345596
Metabolism. 1995 Feb;44(2):267-72
7869926
N Engl J Med. 2003 Nov 13;349(20):1893-906
14610160
J Appl Physiol (1985). 2000 May;88(5):1571-5
10797114
Am J Nephrol. 2007;27(6):545-53
17785964
J Appl Physiol (1985). 2002 Jun;92(6):2617-24
12015381
J Card Fail. 2005 Oct;11(8):576-85
16230259
Eur Heart J. 2006 Oct;27(19):2338-45
16963472
J Am Geriatr Soc. 2001 Dec;49(12):1641-5
11843997
Congest Heart Fail. 2005 Nov-Dec;11(6):322-4; quiz 325
16330908
Ann Intern Med. 2004 Jul 20;141(2):102-12
15262665
J Am Geriatr Soc. 2004 Jul;52(7):1105-13
15209648
Hypertension. 2000 Jun;35(6):1270-7
10856276
Hypertension. 1995 Mar;25(3):437-42
7875769
Am J Med. 1999 May;106(5):506-12
10335721
J Gerontol A Biol Sci Med Sci. 1997 Jul;52(4):M201-8
9224431
Circulation. 1995 Sep 15;92(6):1387-8
7664416
Am J Geriatr Cardiol. 2004 Jan-Feb;13(1):29-38
14724399
J Lab Clin Med. 2004 Jan;143(1):41-51
14749684
Nihon Jinzo Gakkai Shi. 1999 Oct;41(7):692-6
10572394
Peptides. 1996;17(6):1009-15
8899821
Stroke. 2003 Oct;34(10):2333-8
12958329
Am J Clin Nutr. 1998 Sep;68(3):584-90
9734734
Hum Genet. 1998 Jul;103(1):48-50
9737775
Am J Physiol. 1999 Jul;277(1):R332-6
10409290
J Clin Invest. 1996 Jan 1;97(1):244-9
8550842
JAMA. 1995 May 10;273(18):1450-6
7654275
FEBS Lett. 1995 Mar 13;361(1):22-4
7890034
Endocrinology. 1998 May;139(5):2579-87
9564874
Diabetes. 1997 Dec;46(12):1950-7
9392479
Kidney Int. 2000 Apr;57(4):1346-51
10760065
Circulation. 1994 Sep;90(3):1328-33
8087942
Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E366-75
10913037
Hypertension. 1994 Feb;23(2):258-68
8307637
Circulation. 1990 Mar;81(3):1039-46
2155071
J Gerontol A Biol Sci Med Sci. 2004 May;59(5):416-23
15123750
Hypertension. 1992 Feb;19(2 Suppl):II237-42
1735586
Annu Rev Nutr. 2002;22:325-46
12055349
Nutr Rev. 1993 Jan;51(1):1-11
8446301
Clin Sci (Lond). 1995 Oct;89(4):431-9
7493444
J Appl Physiol (1985). 2000 Aug;89(2):687-94
10926655
Respir Res. 2001;2(5):269-72
11686894
Clin Nephrol. 2003 Jul;60 Suppl 1:S2-12
12940529
Gastroenterology. 2003 Apr;124(4):1010-9
12671898
Am J Hypertens. 2000 Mar;13(3):290-7
10777034
Aging Cell. 2003 Feb;2(1):1-7
12882328
Lancet. 2003 Sep 6;362(9386):777-81
13678871
Am J Kidney Dis. 1999 Sep;34(3):445-55
10469854
J Am Soc Nephrol. 1996 May;7(5):676-80
8738801
Am J Physiol. 1995 Jul;269(1 Pt 2):F110-5
7631824
J Am Geriatr Soc. 1999 Jun;47(6):639-46
10366160
Exp Gerontol. 2004 Jan;39(1):17-24
14724060
Circulation. 2003 May 6;107(17):2264-9
12707246
Am J Physiol Regul Integr Comp Physiol. 2000 Mar;278(3):R572-7
10712274
Br J Radiol. 2007 Sep;80 Spec No 1:S23-31
17704323
Sci Prog. 2000;83(Pt 4):317-36
11233367
Am J Physiol. 1997 Feb;272(2 Pt 2):R514-8
9124472
High Alt Med Biol. 2001 Summer;2(2):201-10
11443001
Biochem Biophys Res Commun. 1997 Jan 13;230(2):238-41
9016756
J Appl Physiol (1985). 1999 Oct;87(4):1313-6
10517757
Exp Gerontol. 2003 Aug;38(8):877-86
12915209
J Am Geriatr Soc. 2004 Jun;52(6):961-6
15161462
JAMA. 2005 Aug 10;294(6):691-8
16091571