title: G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
abstract: Genetic variations in preeclampsia (PE) may affect PE risk. The G protein-coupled receptor kinase 4 (GRK4) gene encodes a member of the Ser/Thr protein kinase family and has been linked to both genetic and acquired hypertension. The aim of this study was to investigate the association between polymorphisms (T-rs1024323-C and T-rs1801058-C) in GRK4 and PE in Northern Han Chinese. Using a case-control design, the association between the GRK4 exon-4 T-rs1024323-C and exon-13 T-rs1801058-C polymorphisms and the risk of PE in Northern Han Chinese was assessed in 105 individuals with PE and 103 age- and area-matched normotensive controls. Genotypes were determined by allelic discrimination. The odds ratio and 95% confidence interval were estimated by binary logistic regression. No association was found between the GRK4 polymorphisms (T-rs1024323-C and T-rs1801058-C) and PE, and there was also no relationship with the severity of PE. The risk of homozygous and heterozygous variant allele carriers of the analyzed single-nucleotide polymorphisms did not differ significantly from that of the homozygous wild-type allele carriers, even after adjustment for age, body mass index, (family) history of hypertension and smoking status. The GRK4 (T-rs1024323-C and T-rs1801058-C) polymorphisms were not associated with a risk of PE in the present Northern Han Chinese study group. Thus, the GRK4 polymorphisms do not seem to have an important role in PE in this population.
authors.affiliation: Department of Obstetric, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Cheng-Juan
authors.initials: CJ
authors.lastname: Sun
authors.forename: Wei-Yuan
authors.initials: WY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D054771:G-Protein-Coupled Receptor Kinase 4 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: D054771:G-Protein-Coupled Receptor Kinase 4