title: Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children.
abstract: Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C>T and 1298A>C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.
authors.affiliation: School of Medicine daggerSchool of Dentistry, Institute of Human Genetics, Belgrade, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Damnjanovic
authors.forename: Radomir
authors.initials: R
authors.lastname: Milicevic
authors.forename: Tanja
authors.initials: T
authors.lastname: Novkovic
authors.forename: Olivera
authors.initials: O
authors.lastname: Jovicic
authors.forename: Vera
authors.initials: V
authors.lastname: Bunjevacki
authors.forename: Biljana
authors.initials: B
authors.lastname: Jekic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Lukovic
authors.forename: Ivana
authors.initials: I
authors.lastname: Novakovic
authors.forename: Danka
authors.initials: D
authors.lastname: Redzic
authors.forename: Jelena
authors.initials: J
authors.lastname: Milasin
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D055771:Serbia
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)