Roles of the NF-kappaB pathway in lymphocyte development and function.
This article focuses on the functions of NF-kappaB that vitally impact lymphocytes and thus adaptive immunity. NF-kappaB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kappaB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kappaB executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-kappaB's physiologic impact that we address in this article.
Gerondakis
Steve
S
The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia. gerondakis@burnet.edu.au
Siebenlist
Ulrich
U
D000818:Animals; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D016328:NF-kappa B / Q000502:physiology*
D016328:NF-kappa B
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