Enzymatic activation of a matrix metalloproteinase inhibitor.
Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by beta-glucosidase.
Major Jourden
Jody L
JL
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
Cohen
Seth M
SM
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D015394:Molecular Structure; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001617:beta-Glucosidase / Q000378:metabolism*
D061965:Matrix Metalloproteinase Inhibitors; D011355:Prodrugs; D011480:Protease Inhibitors; D001617:beta-Glucosidase; D020782:Matrix Metalloproteinases
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