title: [The study on the relationship between human papillomavirus infection and pathogenesis of nasal inverted papilloma and its malignant transformation].
abstract: OBJECTIVE
  To investigate the relationship between human papillomavirus (HPV) infection and pathogenesis of nasal inverted papilloma (NIP) and its malignant transformation.
  
  
  METHODS
  Fifty-seven cases of NIP were divided into 2 groups: benign group, squamous cell carcinoma (SCC) arising in NIP group (malignancy group). HPV-DNA types of 6, 11, 16, 18 were detected by polymerase chain reaction (PCR) in 57 cases of NIP. Thirty cases of nasal polyps were control.
  
  
  RESULTS
  Total positive rate of HPV in NIP was 64.9% (37/57). The positive rate of benign group was 60% (27/45), all with single and low risk HPV11 type infection. The positive rate of malignancy group were was 83.3% (10/12), and the majority were HPV16 and HPV18. Five cases had double infection (4 with HPV16 and HPV 18, 1 with HPV11 and HPV18), four had single HPV16 infection, another one had single HPV11 infection. However, HPV-DNA was not detected in any cases of nasal polyps.
  
  
  CONCLUSIONS
  Infection of HPV-DNA has an important effect in pathogenesis of NIP. Meanwhile, there maybe a close relationship between high risk HPV16 type and HPV18 type and malignant transformation of NIP.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhong
authors.forename: Aihui
authors.initials: A
authors.lastname: Yan
authors.forename: Feifei
authors.initials: F
authors.lastname: Jiang
authors.forename: Hongquan
authors.initials: H
authors.lastname: Wei
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology* / Q000821:virology*; D018308:Papilloma, Inverted / Q000473:pathology* / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology; D055815:Young Adult