title: Diffusion tensor imaging: a review for pediatric researchers and clinicians.
abstract: Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that allows for the visualization and characterization of the white matter tracts of the brain in vivo. DTI does not assess white matter directly. Rather, it capitalizes on the fact that diffusion is isotropic (equal in all directions) in cerebral spinal fluid and cell bodies but anisotropic (greater in one direction than the other directions) in axons that comprise white matter. It provides quantitative information about the degree and direction of water diffusion within individual units of volume within the magnetic resonance image, and by inference, about the integrity of white matter. Measures from DTI can be applied throughout the brain or to regions of interest. Fiber tract reconstruction, or tractography, creates continuous 3-dimensional tracts by sequentially piecing together estimates of fiber orientation from the direction of diffusion within individual volume units. DTI has increased our understanding of white matter structure and function. DTI shows nonlinear growth of white matter tracts from childhood to adulthood. Delayed maturation of the white matter in the frontal lobes may explain the continued growth of cognitive control into adulthood. Relative to good readers, adults and children who are poor readers have evidence of white matter differences in a specific region of the temporo-parietal lobe, implicating differences in connections among brain regions as a factor in reading disorder. Measures from DTI changed in poor readers who improved their reading skills after intense remediation. DTI documents injury to white matter tracts after prematurity. Measures indicative of white matter injury are associated with motor and cognitive impairment in children born prematurely. Further research on DTI is necessary before it can become a routine clinical procedure.
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, USA. hfeldman@stanford.edu
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Feldman
authors.forename: Jason D
authors.initials: JD
authors.lastname: Yeatman
authors.forename: Eliana S
authors.initials: ES
authors.lastname: Lee
authors.forename: Laura H F
authors.initials: LH
authors.lastname: Barde
authors.forename: Shayna
authors.initials: S
authors.lastname: Gaman-Bean
mesh_terms: D001921:Brain / Q000002:abnormalities / Q000033:anatomy & histology / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009434:Neural Pathways / Q000002:abnormalities / Q000033:anatomy & histology / Q000473:pathology; D010372:Pediatrics / Q000379:methods
references.citation: Stroke. 2007 Feb;38(2 Suppl):724-30
references.pmid: 17261726
references.citation: J Pediatr. 2004 Nov;145(5):593-9
references.pmid: 15520756
references.citation: Neuroimage. 2000 Jun;11(6 Pt 1):805-21
references.pmid: 10860804
references.citation: J Pediatr. 1999 May;134(5):631-4
references.pmid: 10228300
references.citation: Pediatr Res. 2003 Nov;54(5):672-9
references.pmid: 12904607
references.citation: Neuron. 2009 Dec 10;64(5):624-31
references.pmid: 20005820
references.citation: Sci Am. 2008 Mar;298(3):42-9
references.pmid: 18357821
references.citation: AJNR Am J Neuroradiol. 2003 Sep;24(8):1646-53
references.pmid: 13679287
references.citation: Cereb Cortex. 2006 Apr;16(4):553-60
references.pmid: 16033925
references.citation: Magn Reson Med. 2003 Jan;49(1):7-12
references.pmid: 12509814
references.citation: Magn Reson Med. 1996 Dec;36(6):893-906
references.pmid: 8946355
references.citation: Science. 1999 Mar 19;283(5409):1908-11
references.pmid: 10082463
references.citation: Brain. 2007 Mar;130(Pt 3):654-66
references.pmid: 17347255
references.citation: Neuroimage. 2008 Apr 15;40(3):1044-55
references.pmid: 18295509
references.citation: Cereb Cortex. 2005 Dec;15(12):1848-54
references.pmid: 15758200
references.citation: J Vis. 2008 Jul 29;8(9):15.1-16
references.pmid: 18831651
references.citation: AJNR Am J Neuroradiol. 2008 May;29(5):843-52
references.pmid: 18339719
references.citation: Neuroimage. 2007 Apr 15;35(3):1021-7
references.pmid: 17344066
references.citation: Dev Med Child Neurol. 2007 Oct;49(10):745-50
references.pmid: 17880643
references.citation: Hum Brain Mapp. 2005 Oct;26(2):139-47
references.pmid: 15858815
references.citation: Neuroreport. 1999 Sep 9;10(13):2817-21
references.pmid: 10511446
references.citation: J Cogn Neurosci. 2004 Sep;16(7):1227-33
references.pmid: 15453975
references.citation: J Magn Reson Imaging. 2001 Apr;13(4):534-46
references.pmid: 11276097
references.citation: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10422-7
references.pmid: 10468624
references.citation: Cortex. 2008 Sep;44(8):953-61
references.pmid: 18614162
references.citation: Nat Rev Neurosci. 2003 Jun;4(6):469-80
references.pmid: 12778119
references.citation: Neuroimage. 2008 Nov 1;43(2):213-24
references.pmid: 18694838
references.citation: Curr Opin Neurobiol. 2007 Apr;17(2):258-70
references.pmid: 17379499
references.citation: Biophys J. 2005 Nov;89(5):2927-38
references.pmid: 16100258
references.citation: J Digit Imaging. 2006 Jun;19(2):112-7
references.pmid: 16511673
references.citation: Neuroimage. 2003 Feb;18(2):348-59
references.pmid: 12595188
references.citation: Neuroimage. 2004 Sep;23(1):21-4
references.pmid: 15325348
references.citation: Brain. 1965 Jun;88(2):237-94
references.pmid: 5318481
references.citation: Neuroimage. 2005 May 1;25(4):1266-71
references.pmid: 15850744
references.citation: Neuroreport. 2009 Mar 4;20(4):424-8
references.pmid: 19218872
references.citation: J Magn Reson B. 1996 Jun;111(3):209-19
references.pmid: 8661285
references.citation: Eur J Radiol. 2003 Mar;45(3):169-84
references.pmid: 12595101
references.citation: J Child Neurol. 2009 Jul;24(7):795-800
references.pmid: 19435729
references.citation: Pediatr Res. 2001 Nov;50(5):553-62
references.pmid: 11641446
references.citation: Nat Neurosci. 1999 Oct;2(10):861-3
references.pmid: 10491603
references.citation: AJNR Am J Neuroradiol. 2007 Aug;28(7):1213-22
references.pmid: 17698519
references.citation: Pediatr Radiol. 2007 Dec;37(12):1216-23
references.pmid: 17909782
references.citation: Neuroimage. 2007 Jan 1;34(1):243-52
references.pmid: 17070704
references.citation: Cogn Affect Behav Neurosci. 2007 Sep;7(3):153-91
references.pmid: 17993204
references.citation: Neuroimage. 2006 Jul 15;31(4):1487-505
references.pmid: 16624579
references.citation: AJNR Am J Neuroradiol. 2008 Mar;29(3):483-7
references.pmid: 18039757
references.citation: Neurosci Biobehav Rev. 2006;30(6):718-29
references.pmid: 16887188
references.citation: NMR Biomed. 1995 Nov-Dec;8(7-8):375-86
references.pmid: 8739274
references.citation: Brain. 2005 Oct;128(Pt 10):2224-39
references.pmid: 16141282
references.citation: Magn Reson Med. 2000 Oct;44(4):625-32
references.pmid: 11025519
references.citation: Ann Neurol. 2005 Jan;57(1):8-16
references.pmid: 15597383
references.citation: Ment Retard Dev Disabil Res Rev. 2006;12(2):129-40
references.pmid: 16807910
references.citation: Dev Med Child Neurol. 2010 Jun;52(6):e94-100
references.pmid: 19747208
references.citation: AJNR Am J Neuroradiol. 2008 Apr;29(4):632-41
references.pmid: 18339720
references.citation: Cortex. 2005 Jun;41(3):354-63
references.pmid: 15871600
references.citation: Pediatr Res. 2007 Jun;61(6):732-6
references.pmid: 17426647
references.citation: Neuroimage. 2006 Oct 15;33(1):27-38
references.pmid: 16905335
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2636-41
references.pmid: 9482939
references.citation: AJNR Am J Neuroradiol. 2009 Jan;30(1):120-4
references.pmid: 18832665
references.citation: Dev Med Child Neurol. 2009 Sep;51(9):697-704
references.pmid: 19416315
references.citation: Trends Cogn Sci. 2006 Aug;10(8):363-9
references.pmid: 16843037
references.citation: Neuroimage. 2001 Jun;13(6 Pt 1):1174-85
references.pmid: 11352623
references.citation: Ann Neurol. 1999 Feb;45(2):265-9
references.pmid: 9989633
references.citation: NMR Biomed. 1995 Nov-Dec;8(7-8):333-44
references.pmid: 8739270
references.citation: Proc Natl Acad Sci U S A. 2007 May 15;104(20):8556-61
references.pmid: 17483487
references.citation: Neuroimage. 2006 Oct 1;32(4):1538-48
references.pmid: 16843682
references.citation: Hum Brain Mapp. 2008 Jun;29(6):696-710
references.pmid: 17598163
references.citation: AJNR Am J Neuroradiol. 2009 Mar;30(3):623-8
references.pmid: 19131414
references.citation: NMR Biomed. 2002 Nov-Dec;15(7-8):435-55
references.pmid: 12489094
references.citation: Neuropsychologia. 2009 Jan;47(1):180-94
references.pmid: 18775735