title: Cerebral sinus thrombosis and heparin-induced thrombocytopenia in a patient with paroxysmal nocturnal hemoglobinuria.
abstract: Paroxysmal nocturnal hemoglobinuria is a rare acquired disorder of clonal hematopoietic stem cells and it is characterized as a hypercoagulable disorder. We report a 36-year-old woman with the rare triad of paroxysmal nocturnal hemoglobinuria, cerebral sinus thrombosis triggered by infection, and rapid-onset heparin-induced thrombocytopenia after resensitization of heparin. This case raises caution for heparin-induced thrombocytopenia in paroxysmal nocturnal hemoglobinuria.
authors.affiliation: Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences. kkawase@hiroshima-u.ac.jp
authors.forename: Kayoko
authors.initials: K
authors.lastname: Ishihara-Kawase
authors.forename: Toshiho
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Sayaka
authors.initials: S
authors.lastname: Sugihara
authors.forename: Hitomi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Akiro
authors.initials: A
authors.lastname: Kimura
authors.forename: Masayasu
authors.initials: M
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000188:drug therapy*; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D008582:Meningitis, Aseptic / Q000150:complications; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D001323:Autoantibodies; D006493:Heparin