Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection.
In the current era of organ shortages and long wait times for life-saving transplants, marginal or extended donors are increasingly being considered; one such category of marginal organs is from donors with a previous history of malignancy. Melanoma in particular has been associated with increased risk of developing late recurrence. In this report, we describe a case of fatal donor melanoma transmission to a 64-year-old lung transplant recipient 32 years after surgical excision of the melanoma. Based on this report and review of the available literature, we conclude that a history of donor melanoma, regardless of the stage and time interval from 'curative' surgical resection, should remain a strong relative contraindication to transplantation.
Bajaj
Navkaranbir S
NS
University of Alabama, Ryals School of Public Health, Birmingham, AL, USA. ahyav@uphs.upenn.edu
Watt
Christopher
C
Hadjiliadis
Denis
D
Gillespie
Colin
C
Haas
Andrew R
AR
Pochettino
Alberto
A
Mendez
James
J
Sterman
Daniel H
DH
Schuchter
Lynn M
LM
Christie
Jason D
JD
Lee
James C
JC
Ahya
Vivek N
VN
D046148:Donor Selection; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000209:etiology*; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000601:surgery*; D012878:Skin Neoplasms; D014019:Tissue Donors