title: Autoimmune diseases prior to the diagnosis of multiple sclerosis: a population-based case-control study.
abstract: The objective of this study was to determine whether patients with multiple sclerosis (MS) are more likely to have other autoimmune disorders particularly prior to the diagnosis of MS. We conducted a population-based case-control study of patients enrolled in the Northern California Kaiser Permanente Medical Care Program. Electronic clinical records through 2005 were used to ascertain incident and prevalent MS cases and identify the presence and timing of 44 other diagnoses. Controls were matched 5:1 for gender, age, and Kaiser membership characteristics. We identified 5296 MS cases (including 924 diagnosed between 2001 and 2004) and 26,478 matched controls. Prior to MS diagnosis, cases were more likely than controls to have uveitis (OR = 3.2, 95%; CI 1.7-5.7), inflammatory bowel disease (IBD, OR = 1.7; 95%CI 1.2-2.5), and Bell's palsy (OR = 3.2; 95%CI 1.2-8.3). Cases were also more likely to develop Guillain- Barré syndrome (GBS, OR = 5.0; 95%CI 1.6-15.4) and bullous pemphigoid (OR = 6.7; 95%CI 1.5-29.9). Cases were not more likely than controls to have or to develop rheumatoid arthritis, lupus or thyroiditis. MS may share environmental triggers, genetic susceptibilities and/or alterations in immune homeostasis with IBD and uveitis, but not with other autoimmune disorders.
authors.affiliation: Kaiser Permanente Southern California, Department of Research and Evaluation, and Department of Neurology, Pasadena, CA 91101, USA. Annette.M.Langer-Gould@kp.org
authors.forename: A
authors.initials: A
authors.lastname: Langer-Gould
authors.forename: K B
authors.initials: KB
authors.lastname: Albers
authors.forename: S K
authors.initials: SK
authors.lastname: Van Den Eeden
authors.forename: L M
authors.initials: LM
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000276:immunology; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006279:Health Maintenance Organizations; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D016017:Odds Ratio; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors