title: Disseminated Mycobacterium avium complex infection in a non-HIV-infected patient undergoing continuous ambulatory peritoneal dialysis.
abstract: Isolated bone marrow infection by nontuberculous mycobacteria (NTM) is extremely rare. Recently, we encountered a case of bone marrow Mycobacterium avium complex (MAC) infection, which presented as a fever of unknown origin shortly after starting continuous ambulatory peritoneal dialysis (CAPD). The patient was diagnosed with MAC infection on the basis of PCR-restriction fragment length polymorphism analysis and sequencing of DNA obtained from bone marrow specimens. Although this was a case of severe MAC infection, there was no evidence of infection of other organs. End-stage renal disease (ESRD) patients undergoing dialysis can be considered immunodeficient; therefore, when these patients present with fever of unknown origin, opportunistic infections such as NTM infection should be considered in the differential diagnosis.
authors.affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Chung
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Cha
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Oh
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Nam
authors.forename: Su Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Hye Ryoun
authors.initials: HR
authors.lastname: Kim
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000175:diagnosis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D015269:Mycobacterium avium Complex / Q000235:genetics / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D010531:Peritoneal Dialysis, Continuous Ambulatory; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins