title: [Accuracy evaluation of mammography in the breast cancer screening in Asian women: a community-based follow-up study and meta analysis].
abstract: OBJECTIVE
  To evaluate the accuracy of mammography in breast cancer screening in Asian women.
  
  
  METHODS
  8718 community women in Chengdu were examined by mammography during the routine physical examination from Mar. 2002 to Sep. 2007. Pathological diagnosis and following up results were used as the gold standards for X-ray-positive and -negative findings. The sensitivity, specificity and diagnosis odds ratio were calculated as accuracy indexes. Large scale follow-up studies of breast cancer screening in community in Asian women were collected to evaluate the pooled accuracy of mammography. Diagnosis meta-analysis was conducted with Meta-Disc software to estimate the pooled sensitivity, specificity and DOR, and draw the summary receiver operating characteristic (SROC).
  
  
  RESULTS
  The data of seven studies were included with a total of 223 619 women received mammography for screening breast cancer. The sensitivity (95%CI) and specificity (95%CI) of mammography of community-based follow-up study in Chengdu were 0.889 (0.741 - 0.970) and 0.991 (0.987 - 0.993), respectively. Referring to meta-analysis, random effects models were adopted due to existed heterogeneity among studies. The pooled sensitivity, specificity, DOR with their 95% confidence intervals were 0.845 (0.821 - 0.870), 0.930 (0.929 - 0.931) and 117.271 (65.060 - 211.412), respectively. The Area Under the Curve (AUC) of SROC was 0.9144.
  
  
  CONCLUSIONS
  Due to its high accuracy, mammography deserves to be recommend in breast cancer screening in Asian women.
authors.affiliation: Department of Radiology, Chengdu Women and Children Health Hospital, Chengdu 610031, China.
authors.forename: Min
authors.initials: M
authors.lastname: Kang
authors.forename: Yi
authors.initials: Y
authors.lastname: Pang
authors.forename: Jia-yuan
authors.initials: JY
authors.lastname: Li
authors.forename: Lian-hua
authors.initials: LH
authors.lastname: Liu
authors.forename: Xing-tao
authors.initials: XT
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001208:Asia / Q000453:epidemiology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D012680:Sensitivity and Specificity