Superinfection during treatment of nosocomial infections with tigecycline.
We performed a retrospective and observational study of 51 patients treated with tigecycline, as the treatment for nosocomial infections due to multidrug-resistant microorganisms, to evaluate the superinfection rate and their etiologies. Superinfections were diagnosed in 12 (23.5%) patients (seven due to Pseudomonas aeruginosa, 13.7%) and one patient had P. aeruginosa colonization. Five patients with superinfection died (41.6%), three due to superinfections and two to underlying diseases. The superinfection rate observed during tigecycline treatment is higher than that previously reported. Pseudomonas aeruginosa is the most frequent agent, being the cause of 58.5% of all superinfections.
García-Cabrera
E
E
The Spanish Network for Research in Infectious Diseases, Hospitales Universitarios Virgen del Rocío, Av. Manuel Siurot s/n, 41013 Seville, Spain.
Jiménez-Mejías
M E
ME
Gil Navarro
M V
MV
Gómez-Gómez
M J
MJ
Ortiz-Leyba
C
C
Cordero
E
E
Pachón
J
J
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015995:Prevalence; D012189:Retrospective Studies; D015163:Superinfection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
Pharmacotherapy. 2007 Jul;27(7):1052-7
17594211
Antimicrob Agents Chemother. 2006 Oct;50(10):3375-80
17005820
Braz J Infect Dis. 2005 Oct;9(5):348-56
16410885
Int J Infect Dis. 2005 Sep;9(5):251-61
16099700
Clin Infect Dis. 2008 Feb 15;46(4):567-70
18199038
Emerg Infect Dis. 2004 Mar;10(3):535-8
15109432
BMC Infect Dis. 2005 Oct 19;5:88
16236177
J Antimicrob Chemother. 2007 Jan;59(1):128-31
17082201
Drugs. 2005;65(18):2623-35; discussion 2636-7
16392879
Antimicrob Agents Chemother. 2004 Jun;48(6):2179-84
15155219
Clin Infect Dis. 2008 Jun 1;46(11):1798; author reply 1798-9
18462124
Pharmacotherapy. 2007 Jul;27(7):980-7
17594203
Antimicrob Agents Chemother. 2003 Jan;47(1):400-4
12499224
Antimicrob Agents Chemother. 2005 Nov;49(11):4658-66
16251309