Glomerular lesion and increased cytokine gene expression in renal tissue in patients with decompensated nephrotic syndrome due to chronic GvHD.
The nephrotic syndrome is a rare complication of allogeneic stem cell transplantation (alloHSCT). We present two cases of nephrotic syndrome during chronic graft-versus-host disease (GvHD) involving altered cytokine gene expression in renal tissue. A patient with acute lymphatic leukemia demonstrated nephrotic syndrome due to minimal change disease as a marker of chronic GvHD. A patient with acute lymphoblastic leukemia suffered from severe nephrotic syndrome due to membranous glomerulopathy. In the two presented cases of GvHD-linked nephrotic syndrome, increased cytokine gene expression [tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), interferon gamma (IFN-gamma), interleukin 2 (IL-2), IL-6, and IL-10] assessed using semiquantitative evaluation with reverse transcriptase polymerase chain reaction (RT-PCR) in situ on renal biopsy was observed.
Kaminska
D
D
Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw 50-417, Poland. dorotakaminska@interia.pl
Bernat
B
B
Vakulenko
O
O
Kuzniar
J
J
Tyran
B
B
Suchnicki
K
K
Lange
A
A
Mazanowska
O
O
Halon
A
A
Klinger
M
M
D000328:Adult; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism; D003937:Diagnosis, Differential; D015870:Gene Expression; D006086:Graft vs Host Disease / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D016207:Cytokines