[Actively induced hypothermia following severe traumatic brain injury].
A Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic brain injury reduces cerebral perfusion in the penumbra zone, where local circulation is already reduced. Thus, to date there is no indication for therapeutic hypothermia in TBI patients.
Grände
Per-Olof
PO
Universitetssygehuset i Lund, Anaestesi- og Intensivafdelingen, Denmark.
Welling
Karen-Lise
KL
Eskesen
Vagn
V
Romner
Bertil
B
D000328:Adult; D001930:Brain Injuries / Q000628:therapy*; D002648:Child; D019317:Evidence-Based Medicine; D006801:Humans; D007036:Hypothermia, Induced; D002546:Ischemic Attack, Transient / Q000628:therapy; D011379:Prognosis; D016896:Treatment Outcome