title: Tau, prions and Aβ: the triad of neurodegeneration.
abstract: This article highlights the features that connect prion diseases with other cerebral amyloidoses and how these relate to neurodegeneration, with focus on tau phosphorylation. It also discusses similarities between prion disease and Alzheimer's disease: mechanisms of amyloid formation, neurotoxicity, pathways involved in triggering tau phosphorylation, links to cell cycle pathways and neuronal apoptosis. We review previous evidence of prion diseases triggering hyperphosphorylation of tau, and complement these findings with cases from our collection of genetic, sporadic and transmitted forms of prion diseases. This includes the novel finding that tau phosphorylation consistently occurs in sporadic CJD, in the absence of amyloid plaques.
authors.affiliation: Division of Neuropathology, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK.
authors.forename: Lilla
authors.initials: L
authors.lastname: Reiniger
authors.forename: Ana
authors.initials: A
authors.lastname: Lukic
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Linehan
authors.forename: Peter
authors.initials: P
authors.lastname: Rudge
authors.forename: John
authors.initials: J
authors.lastname: Collinge
authors.forename: Simon
authors.initials: S
authors.lastname: Mead
authors.forename: Sebastian
authors.initials: S
authors.lastname: Brandner
mesh_terms: D016229:Amyloid beta-Peptides / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D016923:Cell Death / Q000235:genetics / Q000502:physiology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D010766:Phosphorylation / Q000235:genetics / Q000502:physiology; D011328:Prions / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D011328:Prions; D016875:tau Proteins
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