title: Screening families of patients with premature coronary heart disease to identify avoidable cardiovascular risk: a cross-sectional study of family members and a general population comparison group.
abstract: BACKGROUND
  Primary prevention should be targeted at individuals with high global cardiovascular risk, but research is lacking on how best to identify such individuals in the general population. Family history is a good proxy measure of global risk and may provide an efficient mechanism for identifying high risk individuals. The aim was to test the feasibility of using patients with premature cardiovascular disease to recruit family members as a means of identifying and screening high-risk individuals.
  
  
  RESULTS
  We recruited family members of 50 patients attending a cardiology clinic for premature coronary heart disease (CHD). We compared their cardiovascular risk with a general population control group, and determined their perception of their risk and current level of screening. 103 (36%) family members attended screening (27 siblings, 48 adult offspring and 28 partners). Five (5%) had prevalent CHD. A significantly higher percentage had an ASSIGN risk score >20% compared with the general population (13% versus 2%, p < 0.001). Only 37% of family members were aware they were at increased risk and only 50% had had their blood pressure and serum cholesterol level checked in the previous three years.
  
  
  CONCLUSIONS
  Patients attending hospital for premature CHD provide a mechanism to contact family members and this can identify individuals with a high global risk who are not currently screened.
authors.affiliation: Section of Public Health, University of Glasgow, Glasgow, G12 8RZ, UK. j.pell@clinmed.gla.ac.uk.
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Thompson
authors.forename: Alastair Ch
authors.initials: ACh
authors.lastname: Pell
authors.forename: Judith
authors.initials: J
authors.lastname: Anderson
authors.forename: Clara K
authors.initials: CK
authors.lastname: Chow
authors.forename: Jill P
authors.initials: JP
authors.lastname: Pell
references.citation: J Cardiopulm Rehabil. 2000 May-Jun;20(3):172-9
references.pmid: 10860199
references.citation: Eur Heart J. 2003 Feb;24(3):249-57
references.pmid: 12590902
references.citation: Ann Hum Genet. 2003 Mar;67(Pt 2):97-106
references.pmid: 12675686
references.citation: Am Heart J. 1998 Mar;135(3):428-34
references.pmid: 9506328
references.citation: Circulation. 1975 Oct;52(4):589-95
references.pmid: 1080450
references.citation: J Clin Epidemiol. 1996 May;49(5):497-503
references.pmid: 8636722
references.citation: Eur J Cardiovasc Prev Rehabil. 2003 Aug;10(4):S1-S10
references.pmid: 14555889
references.citation: Heart. 2010 Feb;96(3):208-12
references.pmid: 19737737
references.citation: Epidemiology. 2001 Mar;12(2):215-21
references.pmid: 11246583