Pinning down response inhibition in the brain--conjunction analyses of the Stop-signal task.
Successful behavior requires a finely-tuned interplay of initiating and inhibiting motor programs to react effectively to constantly changing environmental demands. One particularly useful paradigm for investigating inhibitory motor control is the Stop-signal task, where already-initiated responses to Go-stimuli are to be inhibited upon the rapid subsequent presentation of a Stop-stimulus (yielding successful and unsuccessful Stop-trials). Despite the extensive use of this paradigm in functional neuroimaging, there is no consensus on which functional comparison to use to characterize response-inhibition-related brain activity. Here, we utilize conjunction analyses of successful and unsuccessful Stop-trials that are each contrasted against a reference condition. This conjunction approach identifies processes common to both Stop-trial types while excluding processes specific to either, thereby capitalizing on the presence of some response-inhibition-related activity in both conditions. Using this approach on fMRI data from human subjects, we identify a network of brain structures that was linked to both types of Stop-trials, including lateral-inferior frontal and medial frontal cortical areas and the caudate nucleus. In addition, comparisons with a reference condition matched for visual stimulation identified additional activity in the right inferior parietal cortex that may play a role in enhancing the processing of the Stop-stimuli. Finally, differences in stopping efficacy across subjects were associated with variations in activity in the left anterior insula. However, this region was also associated with general task accuracy (which furthermore correlated directly with stopping efficacy), suggesting that it might actually reflect a more general mechanism of performance control that supports response inhibition in a relatively nonspecific way.
Boehler
C N
CN
Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA. nico.boehler@duke.edu
Appelbaum
L G
LG
Krebs
R M
RM
Hopf
J M
JM
Woldorff
M G
MG
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003463:Cues; D005260:Female; D006801:Humans; D008297:Male; D009068:Movement / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
J Exp Psychol Hum Percept Perform. 1993 Jun;19(3):676-81
8331320
Hum Brain Mapp. 2001 Mar;12(3):131-43
11170305
Neurosci Res. 2002 Jun;43(2):111-7
12067746
Am J Psychiatry. 2006 Jun;163(6):1052-60
16741206
Trends Cogn Sci. 2008 Nov;12(11):418-24
18799345
J Exp Psychol Hum Percept Perform. 1984 Apr;10(2):276-91
6232345
Prog Neurobiol. 1996 Nov;50(4):381-425
9004351
Neuroimage. 1998 Jan;7(1):30-40
9500830
Neurosci Biobehav Rev. 2009 May;33(5):611-2
18977244
J Neurosci. 2009 Aug 12;29(32):10171-9
19675251
Neurosci Biobehav Rev. 2009 May;33(5):690-8
18789354
Psychol Rev. 2014 Jan;121(1):66-95
24490789
J Abnorm Child Psychol. 2008 Oct;36(7):989-98
18461439
Neurosci Biobehav Rev. 2009 May;33(5):631-46
18835296
J Neurosci. 2007 Oct 31;27(44):11860-4
17978025
Nat Rev Neurosci. 2002 Mar;3(3):201-15
11994752
Neuropsychologia. 2009 Nov;47(13):2828-34
19540864
J Exp Psychol Hum Percept Perform. 1992 Nov;18(4):1030-44
1431742
Neuropsychologia. 2006;44(3):384-95
16095637
Cereb Cortex. 2009 Jan;19(1):134-45
18440947
Trends Cogn Sci. 2008 Mar;12(3):99-105
18262825
Brain Res. 2006 Aug 11;1105(1):143-54
16616048
J Abnorm Psychol. 2005 May;114(2):216-22
15869352
Neurosci Biobehav Rev. 2009 May;33(5):647-61
18822313
J Neurosci. 2006 Mar 1;26(9):2424-33
16510720
Dev Psychol. 1999 Jan;35(1):205-13
9923475
Hum Brain Mapp. 2007 Dec;28(12):1347-58
17274022
Neuroimage. 2008 Jul 15;41(4):1352-63
18485743
J Cogn Neurosci. 2000;12 Suppl 2:76-89
11506649
Clin Neurophysiol. 2008 Mar;119(3):556-567
18164656
Int J Psychophysiol. 2005 Feb;55(2):191-8
15649550
Hum Brain Mapp. 2005 Jul;25(3):336-44
15852388
Neuroimage. 2001 Feb;13(2):250-61
11162266
Neuroimage. 2005 Aug 15;27(2):323-40
16019232
Nat Neurosci. 2009 May;12(5):535-40
19396166
Neuroimage. 2008 Sep 1;42(3):1196-206
18588986
J Cogn Neurosci. 2008 Aug;20(8):1434-42
18303978
Neuroimage. 2002 Dec;17(4):1820-9
12498755
Neurosci Biobehav Rev. 2009 May;33(5):662-73
18789963
Psychol Bull. 1997 Jan;121(1):65-94
9000892
J Neurosci. 2007 Sep 12;27(37):9893-900
17855604
J Exp Psychol Hum Percept Perform. 1990 Feb;16(1):121-34
2137514
Neuroimage. 2005 Apr 15;25(3):653-60
15808966
Hum Brain Mapp. 2007 Nov;28(11):1163-77
17538951
Neuroimage. 2003 Sep;20(1):351-8
14527595
J Neurosci. 2007 Apr 4;27(14):3743-52
17409238
J Abnorm Child Psychol. 2007 Oct;35(5):745-58
17668315
Cereb Cortex. 2008 Aug;18(8):1923-32
18245044
J Cogn Neurosci. 2009 Jun;21(6):1193-203
18702592
J Exp Psychol Hum Percept Perform. 1990 Feb;16(1):164-182
2137517
Neuroimage. 2002 Nov;17(3):1562-71
12414294
Cereb Cortex. 2008 Jan;18(1):178-88
17517682
Psychol Rev. 2007 Apr;114(2):376-97
17500631
Neuroimage. 2005 Apr 15;25(3):661-7
15808967
J Neurosci. 2006 Jan 4;26(1):186-92
16399686