New tricks for old biomarkers: thymidylate synthase expression as a predictor of pemetrexed activity in malignant mesothelioma.
Zucali
P A
PA
Department of Oncology, Istituto Clinico Humanitas IRCCS, Rozzano (Milan), Italy. Electronic address: paolo.zucali@humanitas.it.
Giovannetti
E
E
Department of Medical Oncology, VU University Medical Center, Amsterdam; The Netherlands.
Assaraf
Y G
YG
The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Ceresoli
G L
GL
Department of Oncology, Istituto Humanitas Gavazzeni, Bergamo, Italy.
Peters
G J
GJ
Department of Medical Oncology, VU University Medical Center, Amsterdam; The Netherlands.
Santoro
A
A
Department of Oncology, Istituto Clinico Humanitas IRCCS, Rozzano (Milan), Italy.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005971:Glutamates / Q000627:therapeutic use*; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008654:Mesothelioma / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D000068437:Pemetrexed; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D015996:Survival Rate; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D013940:Thymidylate Synthase