title: Resting and post-exercise serum biomarkers of cardiac and skeletal muscle damage in adolescent runners.
abstract: This study examined the response of serum biomarkers of cardiac and skeletal muscle damage at rest and after a routine workout of 21 km run in 12 male adolescent (16.2±0.6 years) long-distance runners. Biomarkers of cardiac [troponins (cTnT, cTnI), creatine kinase MB mass (CK-Mbmass)] and skeletal muscle [creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and hydroxybutyrate dehydrogenase (HBD)] damage were assayed at rest, 2, 4 and 24 h post-exercise. At rest, cTnT and cTnI were not detectable; however, CK, CK-MBmass, AST, ALT and HBD were above corresponding clinical cut-off values. Post-exercise significant elevations above rest were observed for all biomarkers, except ALT, 2 and 4 h following the run, and remained elevated in cTnI, CK, CK-MBmass, LDH and AST 24 h post-workout. A significant increase in data points above clinical cut-off values from rest to post-exercise was reported for cTnT, cTnI and CK at 2 and 4 h, and in cTnI and CK 24 h post-exercise. In conclusion, a 21 km run in adolescent runners increased post-exercise biomarkers of cardiac and skeletal muscle damage.
authors.affiliation: School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China. jnie@ipm.edu.mo
authors.forename: J
authors.initials: J
authors.lastname: Nie
authors.forename: T K
authors.initials: TK
authors.lastname: Tong
authors.forename: K
authors.initials: K
authors.lastname: George
authors.forename: F H
authors.initials: FH
authors.lastname: Fu
authors.forename: H
authors.initials: H
authors.lastname: Lin
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D012146:Rest; D012420:Running / Q000502:physiology*; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D052279:Creatine Kinase, MB Form