Respiratory quotient predicts fat mass gain in premenopausal women.
High respiratory quotient (RQ) has been associated with fat mass (FM) gain in some, but not all studies. Variability among results may reflect differences in the RQ variable measured (fasting vs. 24-h) or may be due to differences in control for factors that affect RQ, such as diet, energy balance, circulating insulin, and insulin sensitivity. The objective of this study was to determine whether different RQ values (fasting, sleeping, nonsleeping, and 24-h) would predict change in FM over 2 years in obesity-prone women, controlling for diet and adjusting for energy balance, circulating insulin, and insulin sensitivity. Participants were 33 previously overweight premenopausal women. Fasting, sleeping, nonsleeping, and 24-h RQ values were measured during controlled-diet conditions by respiratory chamber calorimetry. Intravenous glucose tolerance tests were also performed to adjust for fasting insulin, acute insulin response to glucose, and insulin sensitivity. Over the following 2 years, changes in FM were tracked annually by dual energy X-ray absorptiometry. High nonsleeping RQ (NSRQ) predicted 2-year change in FM independently of energy balance, circulating insulin, and insulin sensitivity. This observation suggests that low postprandial fat oxidation may uniquely predispose obesity-prone individuals to accrual of adipose tissue.
Ellis
Amy C
AC
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA. aellis04@uab.edu
Hyatt
Tanya C
TC
Hunter
Gary R
GR
Gower
Barbara A
BA
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D002153:Calorimetry, Indirect; D002245:Carbon Dioxide / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D017697:Premenopause; D012890:Sleep; D055815:Young Adult
D004041:Dietary Fats; D002245:Carbon Dioxide; D010100:Oxygen
Ann Nutr Metab. 2004;48(3):189-92
15249759
Am J Physiol. 1990 Nov;259(5 Pt 1):E650-7
2240203
Fertil Steril. 2008 Oct;90(4):1275-8
18001731
Sb Lek. 2000;101(1):99-104
10953639
Endocrinology. 2009 Dec;150(12):5639-48
19854865
Int J Bioinform Res Appl. 2007;3(4):504-22
18048316
J Clin Endocrinol Metab. 2000 Mar;85(3):1087-94
10720044
J Clin Endocrinol Metab. 2002 Jan;87(1):71-6
11788625
Int J Obes Relat Metab Disord. 1992 Sep;16(9):667-74
1328091
Obes Res. 2003 Aug;11(8):937-44
12917497
Am J Clin Nutr. 2006 Apr;83(4):803-8
16600931
Proc Natl Acad Sci U S A. 1918 Dec;4(12):370-3
16576330
J Appl Physiol (1985). 1996 May;80(5):1743-8
8727562
Am J Clin Nutr. 2002 Nov;76(5):923-7
12399261
J Clin Endocrinol Metab. 2001 Jul;86(7):3182-7
11443186
Fed Proc. 1980 Jan;39(1):110-5
6985867
J Clin Endocrinol Metab. 2002 Aug;87(8):3814-8
12161515
Horm Res. 1995;44(1):17-22
7649522
J Clin Invest. 1995 Mar;95(3):980-5
7883999
Am J Prev Med. 2007 Jul;33(1):34-40
17572309
Am J Clin Nutr. 2002 Mar;75(3):499-504
11864855
Obes Res. 1995 Sep;3 Suppl 2:173S-178S
8581773
J Clin Invest. 1986 Dec;78(6):1568-78
3782471
Am J Clin Nutr. 2007 Sep;86(3):625-32
17823426
Int J Obes Relat Metab Disord. 1998 Jun;22(6):601-3
9665683
Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1009-17
18765680