title: Nanopatterning molecularly imprinted polymers by soft lithography: a hierarchical approach.
abstract: We use soft lithography to pattern molecularly imprinted polymers (MIPs) at the nanoscale. Patterning occurs via a micro transfer molding process associated with an edge effect. We show using fluorescence microscopy that the nanopatterned synthetic receptors specifically recognize and bind a model target, dansyl-l-phenylalanine. We also demonstrate using AFM a specific swelling of the MIP pattern in the presence of the analyte. We believe that this opens new opportunities for the application of MIPs in microsensors and microbiochips, for example in environmental analysis and biomedical diagnostics.
authors.affiliation: CNRS, LAAS, 7 avenue du colonel Roche, F-31077, Toulouse, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Lalo
authors.forename: Cédric
authors.initials: C
authors.lastname: Ayela
authors.forename: Etienne
authors.initials: E
authors.lastname: Dague
authors.forename: Christophe
authors.initials: C
authors.lastname: Vieu
authors.forename: Karsten
authors.initials: K
authors.lastname: Haupt
mesh_terms: D003619:Dansyl Compounds / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D010649:Phenylalanine / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003619:Dansyl Compounds; D011108:Polymers; C120199:dansyl-phenylalanine; D010649:Phenylalanine