title: Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide.
abstract: A 73-year-old man was admitted with complaints of a 2-month history of generalized weakness and numbness. Laboratory examination revealed hypercalcemia, metabolic alkalosis, and kidney injury, similar to the traditional milk-alkali syndrome. The clinical history and the response to therapy indicated that alphacalcidol and thiazide taken daily were the cause. Recently, it has been recommended the term "milk-alkali syndrome" be replaced by "calcium-alkali syndrome", which broadens the definition of the condition. This case suggests that the calcium-alkali syndrome can occur without calcium and alkali, but rather with alphacalcidol and a thiazide diuretic.
authors.affiliation: Department of Nephrology, Tokyo Medical and Dental University.
authors.forename: Fumie
authors.initials: F
authors.lastname: Satoh
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Okado
authors.forename: Mari
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Wataru
authors.initials: W
authors.lastname: Akita
authors.forename: Mai
authors.initials: M
authors.lastname: Wakabayashi
authors.forename: Akihito
authors.initials: A
authors.lastname: Ohta
authors.forename: Eisei
authors.initials: E
authors.lastname: Sohara
authors.forename: Yumi
authors.initials: Y
authors.lastname: Noda
authors.forename: Tatemitsu
authors.initials: T
authors.lastname: Rai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uchida
authors.forename: Sei
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D001774:Blood Chemical Analysis; D003131:Combined Modality Therapy; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects*; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000009:adverse effects*; D006934:Hypercalcemia / Q000139:chemically induced* / Q000175:diagnosis; D007677:Kidney Function Tests; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D006887:Hydroxycholecalciferols; D006852:Hydrochlorothiazide; C008088:alfacalcidol