title: Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis.
abstract: The objective of this study was to investigate adiponectin levels in both plasma and synovial fluid of female patients with knee osteoarthritis (OA) and to analyze the correlation between adiponectin and degradation markers of cartilage matrix in synovial fluid. Thirty female patients with knee OA were enrolled in this study. Levels of adiponectin and degradation markers of cartilage matrix were measured using enzyme-linked immunosorbent assay. Adiponectin level in synovial fluid was significantly lower with respect to paired plasma level (0.93 ± 0.64 vs. 7.50 ± 3.29 μg/ml, P < 0.001). Correlation analysis showed that synovial fluid adiponectin significantly correlated with degradation markers of aggrecan, AGG1 (r = 0.441, P = 0.015) and AGG2 (r = 0.445, P = 0.014), but not significantly correlated with degradation marker of collagen II, CTX-II. These findings suggest that adiponectin might involve in the regulation of the degradation of cartilage matrix in OA.
authors.affiliation: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Hao
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Wu
authors.forename: Yuanhui
authors.initials: Y
authors.lastname: Duan
authors.forename: Deling
authors.initials: D
authors.lastname: Li
authors.forename: Guixing
authors.initials: G
authors.lastname: Qiu
mesh_terms: D052242:Adiponectin / Q000032:analysis / Q000378:metabolism*; D000368:Aged; D053674:Aggrecans / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D064236:Cartilage Oligomeric Matrix Protein; D002358:Cartilage, Articular / Q000378:metabolism; D024043:Collagen Type II / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D064235:Matrilin Proteins; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry / Q000378:metabolism*
chemical_list: C508319:ACAN protein, human; D052242:Adiponectin; D053674:Aggrecans; D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010446:Peptide Fragments; C577553:TSP5 protein, human; C543437:collagen II C-telopeptide
references.citation: Arthritis Rheum. 1995 Nov;38(11):1535-40
references.pmid: 7488272
references.citation: J Immunol. 2006 Apr 1;176(7):4468-78
references.pmid: 16547285
references.citation: Arthritis Rheum. 1986 Aug;29(8):1039-49
references.pmid: 3741515
references.citation: Biochem J. 1997 Aug 15;326 ( Pt 1):235-41
references.pmid: 9337874
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10308-13
references.pmid: 15210937
references.citation: Int J Obes (Lond). 2009 Apr;33(4):424-39
references.pmid: 19290012
references.citation: Gut. 2009 Dec;58(12):1583-9
references.pmid: 19570765
references.citation: JAMA. 2003 Oct 1;290(13):1709-10
references.pmid: 14519703
references.citation: J Biol Chem. 2004 Mar 26;279(13):12152-62
references.pmid: 14699128
references.citation: Osteoarthritis Cartilage. 2006 Jul;14(7):690-5
references.pmid: 16527497
references.citation: Circ Res. 2004 Mar 5;94(4):e27-31
references.pmid: 14752031
references.citation: Curr Opin Lipidol. 2003 Dec;14(6):561-6
references.pmid: 14624132
references.citation: Osteoarthritis Cartilage. 2008 Sep;16(9):1101-9
references.pmid: 18261936
references.citation: Curr Opin Pharmacol. 2002 Jun;2(3):322-9
references.pmid: 12020478
references.citation: J Biol Chem. 1992 Sep 25;267(27):19470-4
references.pmid: 1326552
references.citation: J Rheumatol. 1996 Jul;23(7):1221-6
references.pmid: 8823696
references.citation: J Rheumatol. 1998 Nov;25(11):2181-6
references.pmid: 9818662
references.citation: Biochim Biophys Acta. 2006 Aug;1762(8):711-8
references.pmid: 16891099
references.citation: Nature. 2003 Jun 12;423(6941):762-9
references.pmid: 12802337
references.citation: Ann Rheum Dis. 2006 Nov;65(11):1403-5
references.pmid: 17038451
references.citation: Best Pract Res Clin Rheumatol. 2008 Apr;22(2):351-84
references.pmid: 18455690
references.citation: Arthritis Rheum. 2006 Jul;54(7):2084-95
references.pmid: 16802343
references.citation: Epidemiology. 1999 Mar;10(2):161-6
references.pmid: 10069252
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56
references.pmid: 15181022