Norclerodane diterpenoids from rhizomes of Dioscorea bulbifera.
Three norclerodane diterpenoids, diosbulbins K-M, and one analogous enolglycoside, diosbulbinoside G, together with four norclerodane diterpenoids, diosbulbins B, E, F and G, were isolated from rhizomes of Dioscorea bulbifera. Their structures were established by spectroscopic and chemical methods, including 1H and 13C NMR, NOESY, HSQC, HMBC, and HRMS analyses. The relative configurations of diosbulbins K and L, and diosbulbin F were confirmed by X-ray crystallographic diffraction analysis, and the absolute stereochemistry of diosbulbin K was determined by a modified Mosher's method. The 13C NMR spectroscopic data for diosbulbins E, F and G were also measured for the first time. The compounds did not show significant cytotoxic and anti-bacterial activities.
Liu
Hai
H
The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China.
Chou
Gui-Xin
GX
Guo
Yin-Long
YL
Ji
Li-Li
LL
Wang
Jun-Ming
JM
Wang
Zheng-Tao
ZT
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D027742:Dioscorea / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure
D000935:Antifungal Agents; D004224:Diterpenes