title: Acute ischemic stroke lasting for 5 days without definite lesions on diffusion-weighted magnetic resonance imaging in a patient with severe leukoaraiosis.
abstract: The reported frequency of false-negative diffusion-weighted magnetic resonance imaging (DWI) cases is 3.5%-25%. However, territorial stroke (eg, middle cerebral artery territory) with negative DWI is very rare. We report a case of territorial ischemic stroke persisting for 5 days without identification of a definite lesion on DWI but with decreased perfusion on perfusion computed tomography in a patient with underlying severe leukoaraiosis. This case suggests that severe leukoaraiosis might be responsible for the negative finding on DWI in acute ischemic stroke.
authors.affiliation: Department of Neurology, The Catholic University of Korea, St. Mary's Hospital, Seoul, Korea.
authors.forename: Soo Jeong
authors.initials: SJ
authors.lastname: Han
authors.forename: Beum Saeng
authors.initials: BS
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Shon
authors.forename: A-Hyun
authors.initials: AH
authors.lastname: Cho
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002533:Cerebral Angiography / Q000379:methods; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D055420:Perfusion Imaging / Q000379:methods; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed