Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins.
A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.
Tubaro
Aurelia
A
Dipartimento dei Materiali e delle Risorse Naturali, Università di Trieste, Via A. Valerio 6, 34127 Trieste, Italy. tubaro@units.it
Giangaspero
Anna
A
Sosa
Silvio
S
Negri
Roberto
R
Grassi
Gianpaolo
G
Casano
Salvatore
S
Della Loggia
Roberto
R
Appendino
Giovanni
G
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002186:Cannabinoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002188:Cannabis / Q000737:chemistry*; D003436:Croton Oil; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology; D004423:Ear; D056626:Inflorescence; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D002186:Cannabinoids; D010936:Plant Extracts; D003436:Croton Oil