title: Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm.
abstract: It has been suggested that a cardinal symptom of mania is over-activity and exaggerated goal-directed behavior. Nevertheless, few attempts have been made to quantify this behavior objectively in a laboratory environment. Having a methodology to assess over-activity reliably might be useful in distinguishing manic bipolar disorder (BD) from schizophrenia (SCZ) during highly activated states. In the current study, quantifiable measures of object interaction were assessed using a multivariate approach. Additionally, symptom correlates of over-activity were assessed. Patients admitted to an acute care psychiatric hospital for either BD with mania or SCZ (paranoid and non-paranoid subtypes) as well as non-patient comparison (NC) participants were assessed in an open field setting referred to as the human Behavioral Pattern Monitor (hBPM). Activity and interactions with novel and engaging objects were recorded for 15min via a concealed video camera and rated for exploratory behavior. Both BD and SCZ patients spent more time near the objects and exhibited more overall walking compared to NC. In contrast, BD patients exhibited greater physical contact with objects (number of object interactions and time spent with objects) relative to SCZ patients or NC participants, as well as more perseverative and socially disinhibited behaviors, indicating a unique pattern of over-activity and goal-directed behavior. Further analyses revealed a distinction between SCZ patients according to their subtype. The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ.
authors.affiliation: Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-8218, USA. wperry@ucsd.edu
authors.forename: William
authors.initials: W
authors.lastname: Perry
authors.forename: Arpi
authors.initials: A
authors.lastname: Minassian
authors.forename: Brook
authors.initials: B
authors.lastname: Henry
authors.forename: Meegin
authors.initials: M
authors.lastname: Kincaid
authors.forename: Jared W
authors.initials: JW
authors.lastname: Young
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000150:complications*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications*; D013997:Time Factors; D014741:Video Recording; D055815:Young Adult
references.citation: Mol Psychiatry. 1997 Jul;2(4):311-3
references.pmid: 9246671
references.citation: Am J Psychiatry. 2005 Sep;162(9):1680-7
references.pmid: 16135628
references.citation: Dev Psychopathol. 1997 Fall;9(4):633-52
references.pmid: 9448999
references.citation: Br J Psychiatry. 1978 Nov;133:429-35
references.pmid: 728692
references.citation: J Affect Disord. 1986 Mar-Apr;10(2):137-52
references.pmid: 2941470
references.citation: Behav Brain Res. 1993 Feb 26;53(1-2):11-20
references.pmid: 8466655
references.citation: J Psychiatr Res. 2010 Feb;44(3):168-76
references.pmid: 19700172
references.citation: J Clin Psychiatry. 1997 Dec;58(12):538-46
references.pmid: 9448657
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Schizophr Bull. 2008 Jul;34(4):734-42
references.pmid: 18515820
references.citation: J Affect Disord. 2001 Dec;67(1-3):89-96
references.pmid: 11869755
references.citation: Psychol Assess. 2005 Sep;17(3):324-35
references.pmid: 16262458
references.citation: Pharmacol Biochem Behav. 1986 Jul;25(1):277-88
references.pmid: 2875472
references.citation: Neurosci Biobehav Rev. 2007;31(6):882-96
references.pmid: 17706782
references.citation: Biol Psychiatry. 2003 Feb 15;53(4):352-9
references.pmid: 12586455
references.citation: Mol Psychiatry. 2006 Feb;11(2):125-33, 115
references.pmid: 16261167
references.citation: Arch Gen Psychiatry. 1987 Jun;44(6):573-88
references.pmid: 3579504
references.citation: Annu Rev Clin Psychol. 2008;4:325-48
references.pmid: 18370620
references.citation: Psychiatr Dev. 1986 Autumn;4(3):167-226
references.pmid: 3809156
references.citation: Neuropsychology. 2002 Oct;16(4):481-90
references.pmid: 12382987
references.citation: J Affect Disord. 2009 Jul;116(1-2):30-6
references.pmid: 19038460
references.citation: J Affect Disord. 2003 Jan;73(1-2):133-46
references.pmid: 12507746
references.citation: Schizophr Res. 1995 Feb;14(3):229-34
references.pmid: 7766534
references.citation: Biol Psychiatry. 2001 May 1;49(9):741-52
references.pmid: 11331082
references.citation: Arch Gen Psychiatry. 2009 Oct;66(10):1072-80
references.pmid: 19805697
references.citation: Psychopathology. 2007;40(1):54-60
references.pmid: 17065838
references.citation: J Affect Disord. 2010 Jan;120(1-3):200-6
references.pmid: 19435640
references.citation: Arch Gen Psychiatry. 1985 May;42(5):441-7
references.pmid: 3872649
references.citation: Am J Psychiatry. 2006 Feb;163(2):265-71
references.pmid: 16449480
references.citation: Br J Psychiatry. 1990 Jun;156:788-97
references.pmid: 2207509
references.citation: Psychopharmacology (Berl). 2010 Feb;208(3):443-54
references.pmid: 20020109
references.citation: Brain. 1983 Jun;106 (Pt 2):237-55
references.pmid: 6850269
references.citation: Nature. 1997 Apr 24;386(6627):824-7
references.pmid: 9126739