title: Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site.
abstract: FNR-dependent activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF, which bind to overlapping targets adjacent to the DNA site for FNR. The NsrR target is inactivated by mutation at the Salmonella enterica serovar Typhimurium nrf promoter.
authors.affiliation: School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom. D.F.Browning@bham.ac.uk
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Browning
authors.forename: David J
authors.initials: DJ
authors.lastname: Lee
authors.forename: Stephen
authors.initials: S
authors.lastname: Spiro
authors.forename: Stephen J W
authors.initials: SJ
authors.lastname: Busby
mesh_terms: D001483:Base Sequence; D003574:Cytochrome c Group / Q000235:genetics / Q000378:metabolism; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D048168:Escherichia coli K12 / Q000235:genetics* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D009154:Mutation; D009569:Nitric Oxide / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000502:physiology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D003574:Cytochrome c Group; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C529899:NsrR protein, E coli; D014157:Transcription Factors; D009569:Nitric Oxide; C022302:cytochrome C-552
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