Differences in albuminuria between Hispanics and whites: an evaluation by genetic ancestry and country of origin: the multi-ethnic study of atherosclerosis.
BACKGROUND
Reports show higher prevalence of albuminuria among Hispanics compared with whites. Differences by country of origin or genetic background are unknown.


RESULTS
In Multi-Ethnic Study of Atherosclerosis, we studied the associations of both genetic ancestry and country of origin with albumin to creatinine ratio among 1417 Hispanic versus white participants using multivariable linear regression and back transforming beta coefficients into relative difference (%RD, 95% CI). Percentage European, Native American, and African ancestry components for Hispanics were estimated using genetic admixture analysis. The proportions of European, Native American, and African genetic ancestry differed significantly by country of origin (P<0.0001); Mexican/Central Americans had the highest Native American (41+/-13%), Puerto Ricans had the highest European (61+/-15%), and Dominicans had the highest African (39+/-21%) ancestry. Hispanic ethnicity was associated with higher albumin/creatinine ratio compared with whites, but the association varied with the country of origin (adjusted P interaction=0.04). Mexican/Central Americans and Dominicans had higher albumin/creatinine ratio compared with whites after adjustment (RD 19%, 2% to 40% and RD 27%, 1% to 61%), but not Puerto Ricans (RD 8%, -12% to 34%). Higher Native American ancestry was associated with higher albuminuria after age and sex adjustment among all Hispanics (RD 11%, 1% to 21%) but was attenuated after further adjustment. Higher European ancestry was independently associated with lower albumin/creatinine ratio among Puerto Ricans (-21%, -34% to -6%) but not among Mexican/Central Americans and Dominicans.


CONCLUSIONS
Hispanics are a heterogeneous group with varying genetic ancestry. Risks of albuminuria differ across the country of origin groups. These differences may be due, in part, to differences in genetic ancestral components.
Peralta
Carmen A
CA
Department of Medicine, University of California San Francisco, San Francisco, CA 94121, USA. CarmenAlicia.Peralta@ucsf.edu
Li
Yongmei
Y
Wassel
Christina
C
Choudhry
Shweta
S
Palmas
Walter
W
Seldin
Michael F
MF
Risch
Neil
N
Siscovick
David
D
Arnett
Donna
D
Psaty
Bruce
B
Shlipak
Michael G
MG
D000368:Aged; D000419:Albuminuria / Q000208:ethnology* / Q000235:genetics; D000483:Alleles; D050197:Atherosclerosis / Q000208:ethnology / Q000235:genetics; D002489:Central America; D003404:Creatinine / Q000097:blood; D004293:Dominican Republic; D005260:Female; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011647:Puerto Rico; D012044:Regression Analysis; D012306:Risk; D012709:Serum Albumin / Q000032:analysis; D044465:White People / Q000235:genetics
D012709:Serum Albumin; D003404:Creatinine
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