Final report of the safety assessment of allantoin and its related complexes.
Allantoin is a heterocyclic organic compound. Allantoin ascorbate, allantoin biotin, allantoin galacturonic acid, allantoin glycyrrhetinic acid, allantoin panthenol, and allantoin polygalacturonic acid are complexes of allantoin. All of the ingredients in this review act as skin-conditioning agents. Allantoin was reported to be used in 1376 cosmetic products at concentrations up to 2%. There are data gaps regarding use and concentration of the remaining allantoin complexes. Ascorbic acid, biotin, glycyrrhetinic acid, and panthenol have been determined by the CIR Expert Panel to be safe. Galacturonic acid and polygalacturonic acid have not been reviewed by the CIR Expert Panel, and substantial data on these chemicals were not available. The safety test data in this safety assessment and in previous safety assessments were considered sufficient to support the safety of allantoin and the allantoin complexes in product categories and at concentrations reviewed in this safety assessment.
Becker
Lillian C
LC
Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. cirinfo@cir-safety.org
Bergfeld
Wilma F
WF
Belsito
Donald V
DV
Klaassen
Curtis D
CD
Marks
James G
JG
Shank
Ronald C
RC
Slaga
Thomas J
TJ
Snyder
Paul W
PW
Alan Andersen
F
F
D000481:Allantoin / Q000031:analogs & derivatives / Q000633:toxicity*; D000818:Animals; D000830:Animals, Laboratory; D003257:Consumer Product Safety; D003358:Cosmetics / Q000633:toxicity*; D003879:Dermatologic Agents / Q000633:toxicity*; D006801:Humans; D018570:Risk Assessment; D018675:Toxicity Tests
D003358:Cosmetics; D003879:Dermatologic Agents; D000481:Allantoin