[APOE gene polimorphism and lithogenicity of the bile in the women with cholelithiasis].
OBJECTIVE
to study the frequency of alleles and genotypes of APOE gene in women with gallstone disease (GSD), and also to research the association of the APOE gene polymorphism and bile lithogenicity indices.
were investigated 104 women after cholecystectomy about verified cholesterol gallstones, and 176 women from the female Novosibirsk population, they were control group for the comparison of the frequency of APOE alleles and genotypes. Gallbladder bile (bile cholesterol, common bile acids) was investigated in women with GSD. Blood serum lipids and APOEgene polymorphism were studied in all women.


RESULTS
APOE gene polymorphism in the women with GSD did not differ from those registered in control group from women population. At the presence of APOE4 allele at the women with GSD the significant increase of gallbladder biliary cholesterol level was marked. In the women with GSD with various APOE genotypes average levels of blood serum lipids, common bile acids and bile cholesterol indices were similar.
Grigor'eva
I N
IN
Nikitenko
T M
TM
Shakhtshneĭder
E V
EV
Kulikov
I V
IV
Voevoda
M I
MI
D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D016022:Case-Control Studies; D002769:Cholelithiasis / Q000235:genetics* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D042882:Gallstones / Q000235:genetics / Q000378:metabolism; D005787:Gene Frequency; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D001647:Bile Acids and Salts; D008055:Lipids; D002784:Cholesterol