High content of Langerhans cells in malignant lymphoma--incidence and significance.
We describe 25 patients, 14 with classical Hodgkin lymphoma and 11 with non-Hodgkin lymphoma, in all of whom an excess of Langerhans cells was evident. Except for the first three cases, in which the excess of Langerhans cells was identified on routine slides, the remaining cases were disclosed by actively investigating lymphomas with excess of CD68+ histiocytes and performing CD1a and S-100 protein immunostains. Although no clonality study was performed on the Langerhans cells, we endorse the view which states that in the above association, the Langerhans cells are polyclonal. Fourteen cases of Hodgkin lymphoma with a large number of Langerhans cells were identified in a cohort of 231 classical Hodgkin lymphomas. We compared the features of classical Hodgkin lymphoma with abundant Langerhans cells with those without Langerhans cells. Our analysis reveals that Hodgkin lymphoma with Langerhans cell excess shows greater LMP1/EBV expression (P = .007) and lower p53 expression (P = .042) in the Hodgkin-Reed-Sternberg cells but is not associated with a poorer outcome.
Benharroch
Daniel
D
Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. benaroch@bgu.ac.il
Guterman
Gali
G
Levy
Itai
I
Shaco-Levy
Ruthy
R
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D007801:Langerhans Cells / Q000378:metabolism / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016539:Reed-Sternberg Cells / Q000473:pathology; D055815:Young Adult; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule
Lancet Oncol. 2005 Jun;6(6):435-7
15925822
Hum Pathol. 2006 Jan;37(1):32-9
16360413
J Exp Med. 2002 Aug 19;196(4):417-30
12186835
Virchows Arch. 1999 Mar;434(3):259-62
10190308
Oncogene. 1997 Jun 19;14(24):2899-916
9205097
J Natl Med Assoc. 1994 Jan;86(1):65-9
8151725
Arch Dis Child. 2009 Nov;94(11):904-8
19457881
Br J Cancer. 2004 Aug 2;91(3):572-9
15226778
Am J Hematol. 2001 Dec;68(4):284-6
11754419
J Clin Pathol. 2005 Jan;58(1):104-6
15623497
Arch Pathol Lab Med. 2001 Jul;125(7):958-60
11419987
Am J Surg Pathol. 2001 May;25(5):630-6
11342775
Am J Surg Pathol. 1983 Sep;7(6):529-33
6605095
Cancer. 1993 Feb 1;71(3):865-73
8431870
Clin Exp Dermatol. 2000 Jul;25(5):413-8
11012599
Am J Clin Pathol. 1986 Jan;85(1):111-4
3510049
J Virol. 2004 Feb;78(4):1665-74
14747532
Pediatr Hematol Oncol. 1997 Nov-Dec;14(6):585-8
9383812
N Engl J Med. 2000 Jun 29;342(26):1969-78
10877650