Acute promyelocytic leukemia during pregnancy.
OBJECTIVE
To report our experience about a woman with acute promyelocytic leukemia (APL) during pregnancy. We focus on the obstetric treatment of our patient.


METHODS
Case report.


METHODS
University Hospital.


METHODS
A 32-year-old-woman, gravida 2, para 1, at the 25th week of pregnancy with a diagnosis of APL.


METHODS
Multidisciplinary approach to the problem with the aim to ensure a good outcome for both the mother and the baby.


METHODS
Treatment of maternal malignancy and fetal outcome.


RESULTS
At discharge, after 2 months in hospital, the baby had no neurologic or sensitive deficiencies, and his general health was good. The mother is now undergoing the third and last consolidation step with good results, and APL is in remission.


CONCLUSIONS
In cases of APL during the second and third trimesters, the modern chemotherapy associated with close monitoring of maternal and fetal well-being could ensure a good outcome for both the mother and the baby.
Ganzitti
Laura
L
Clinic of Obstetrics and Gynaecology, University Hospital of Udine, Udine, Italy. ganzittilaura@live.it
Fachechi
Giorgio
G
Driul
Lorenza
L
Marchesoni
Diego
D
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D005323:Fetal Monitoring; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D007231:Infant, Newborn; D033183:Interdisciplinary Communication; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000628:therapy; D011262:Pregnancy Trimester, Second; D014212:Tretinoin / Q000008:administration & dosage
D014212:Tretinoin; D003907:Dexamethasone; D015255:Idarubicin