title: Comparison of the effects of intravenous administration of isotonic and hypertonic sodium bicarbonate solutions on venous acid-base status in dehydrated calves with strong ion acidosis.
abstract: OBJECTIVE-To compare the effects of IV administration of isotonic (1.3%) and hypertonic (8.4%) sodium bicarbonate (NaHCO(3)) solutions on acid-base status in dehydrated calves with strong ion (metabolic) acidosis. DESIGN-Randomized controlled clinical trial. ANIMALS-50 calves with diarrhea and severe dehydration. PROCEDURES-Calves were randomly assigned to receive isotonic NaHCO(3) solution (65 mL/kg [29.5 mL/lb], IV) over 3 hours (n = 30) or hypertonic NaHCO(3) solution (10 mL/kg [4.5 mL/lb], IV) over 20 minutes (20). Blood samples were collected at 0 hours (immediately prior to solution administration) and at 0.5, 1, 2, and 4 hours after administration began. Samples were submitted for blood gas analysis, serum biochemical analysis, and determination of blood Na(+), K(+), and Cl(-) concentrations and percentage change in plasma volume. RESULTS-Calves that received isotonic NaHCO(3) solution had an increase in venous blood pH, HCO(3) concentration, and base excess; a small, transient increase in Po(2); and no change in Pco(2) within 4 hours after administration began. Calves that received hypertonic NaHCO(3) solution had an immediate increase in venous blood pH, HCO(3) concentration, and base excess; a small, transient increase Pco(2); and no change in Po(2) within 0.5 hours after treatment began. Plasma volume increased to a greater extent following administration of isotonic solution than after administration of hypertonic solution. CONCLUSIONS AND CLINICAL RELEVANCE-IV administration of 8.4% NaHCO(3) solution in small volumes provided fast and effective improvement of severe acid-base abnormalities in calves with severe strong ion acidosis but did not improve hydration status as well as administration of a larger volume of isotonic NaHCO(3) solution.
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, 42070, Konya, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Coskun
authors.forename: Ismail
authors.initials: I
authors.lastname: Sen
authors.forename: Hasan
authors.initials: H
authors.lastname: Guzelbektes
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ok
authors.forename: Kursat
authors.initials: K
authors.lastname: Turgut
authors.forename: Sebnem
authors.initials: S
authors.lastname: Canikli
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000503:physiopathology; D003681:Dehydration / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D010953:Plasma Volume; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D017693:Sodium Bicarbonate