In vivo molecular imaging using nanomaterials: general in vivo characteristics of nano-sized reagents and applications for cancer diagnosis.
Nanoparticles present a new collection of contrast agents for the field of in vivo molecular imaging. This review focuses on promising molecular imaging probes for optical and magnetic resonance imaging based on four representative nanomaterial(s) platforms: quantum dots, upconversion phosphors, superparamagnetic iron oxides, and dendrimer-based agents. Quantum dots are extremely efficient fluorescent nanoparticles with size-tunable emission properties, enabling high sensitivity and greater depth penetration. Their heavy metal composition and long retention in the body, however, pose concerns for clinical translational applications. Upconversion phosphors generate excellent signal-to-background contrast because they emit light with higher energy than the excitation photons and autofluorescence signals. For MRI, iron oxide particles also generate excellent signal and have been used in liver imaging and for cell tracking studies. As they are metabolized through endogenous iron salvage pathways, they have already been introduced as clinical contrast agents. Lastly, dendrimers, a 'soft' nanoparticle, can be used as a structural basis for the attachment of small molecule imaging agents and/or targeting groups. This array of nanoparticles should offer insights into the uses and potentials of nanoparticles for the molecular imaging.
Rosenblum
Lauren T
LT
Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA.
Kosaka
Nobuyuki
N
Mitsunaga
Makoto
M
Choyke
Peter L
PL
Kobayashi
Hisataka
H
D000818:Animals; D058948:Cell Tracking; D003287:Contrast Media; D050091:Dendrimers; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis*; D045663:Quantum Dots
D003287:Contrast Media; D050091:Dendrimers; D058185:Magnetite Nanoparticles
J Magn Reson Imaging. 2007 May;25(5):884-99
17457803
Adv Drug Deliv Rev. 2009 Jun 21;61(6):428-37
19376175
J Natl Cancer Inst. 2004 May 5;96(9):703-8
15126607
Biomaterials. 2008 Oct;29(30):4122-8
18675453
Nanoscale Res Lett. 2007 Jun;2(6):265-281
21394238
Cancer Res. 2007 Sep 1;67(17):8223-8
17804736
Nat Biotechnol. 2003 Jan;21(1):47-51
12459736
Nano Lett. 2007 Jun;7(6):1711-6
17530812
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12617-21
12235356
Magn Reson Med. 2002 Apr;47(4):751-8
11948737
Eur J Pharm Biopharm. 2008 Jan;68(1):138-52
17689938
Circulation. 2004 Nov 23;110(21):3378-83
15557385
Bioconjug Chem. 2000 Nov-Dec;11(6):910-7
11087341
NMR Biomed. 2004 Nov;17(7):484-99
15526347
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10901-6
15256592
Radiology. 2002 Mar;222(3):661-6
11867782
ACS Nano. 2007 Nov;1(4):258-64
19079788
Angew Chem Int Ed Engl. 2007;46(23):4346-9
17465433
Curr Pharm Biotechnol. 2004 Dec;5(6):539-49
15579043
J Comput Tomogr. 1981 Dec;5(6):543-7
7053127
Nat Biotechnol. 2004 Jan;22(1):93-7
14661026
Mol Pharm. 2008 May-Jun;5(3):449-63
18393438
N Engl J Med. 2003 Jun 19;348(25):2491-9
12815134
J Control Release. 2009 Sep 1;138(2):90-102
19445982
Blood. 2004 Aug 15;104(4):1217-23
15100158
Adv Drug Deliv Rev. 2006 Dec 1;58(14):1471-504
17116343
Expert Rev Mol Diagn. 2006 Mar;6(2):231-44
16512782
Toxicol Sci. 2009 Dec;112(2):276-96
19684286
Toxicol Appl Pharmacol. 2009 Aug 1;238(3):280-8
19379767
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1226-40
18495291
Biomaterials. 2008 Mar;29(7):937-43
18061257
Nat Biotechnol. 2006 Mar;24(3):339-43
16501578
Neoplasia. 2005 Nov;7(11):984-91
16331884
Bioconjug Chem. 2003 Mar-Apr;14(2):388-94
12643749
Nat Med. 2004 Sep;10(9):993-8
15334072
Mol Imaging. 2003 Jan;2(1):1-10
12926232
Cancer Res. 2001 Jul 1;61(13):4966-70
11431325
Cancer Res. 2003 Jan 15;63(2):271-6
12543772
Radiology. 2007 Nov;245(2):333-56
17940297
J Control Release. 2006 Apr 10;111(3):343-51
16490277
Nat Clin Pract Cardiovasc Med. 2006 Oct;3(10):554-62
16990841
Nat Nanotechnol. 2010 Jan;5(1):42-7
19893516
Bioconjug Chem. 2007 Mar-Apr;18(2):389-96
17263568
Expert Opin Drug Deliv. 2009 Oct;6(10):1091-112
19691443
Adv Drug Deliv Rev. 2005 Dec 14;57(15):2215-37
16297497
J Invest Dermatol. 2009 Dec;129(12):2818-22
19536144
Ann Biomed Eng. 2006 Jan;34(1):23-38
16496086
IEEE Eng Med Biol Mag. 2009 Jan-Feb;28(1):12-22
19150767
Magn Reson Med. 2001 Oct;46(4):781-8
11590655
J Am Chem Soc. 2008 Apr 30;130(17):5642-3
18393419
Adv Drug Deliv Rev. 2005 Dec 14;57(15):2271-86
16290152
Anal Biochem. 1999 Feb 1;267(1):30-6
9918652
Mol Pharm. 2008 Jul-Aug;5(4):540-7
18672950
Nat Biotechnol. 2007 Oct;25(10):1165-70
17891134
J Magn Reson Imaging. 2004 Sep;20(3):512-8
15332261
Biomaterials. 2007 Nov;28(31):4717-32
17686516
J Am Chem Soc. 2003 Sep 24;125(38):11466-7
13129327
Nat Mater. 2005 Jun;4(6):435-46
15928695
Adv Drug Deliv Rev. 2008 Dec 14;60(15):1627-37
18930086