title: Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet.
abstract: Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol. The aims of this study were: (1) to determine age-related changes in plasma lipid profiles, and (2) to determine the effect of fenofibrate, an activator of peroxisome proliferator activated receptor alpha (PPAR alpha), on plasma lipid profiles in normal rats on a standard diet. Male Sprague-Dawley (SD) rats (n=15) were fed standard chow and water from 10 to 25 weeks of age. During that period, we measured daily food intake, body weight, fasting and random blood glucose levels, plasma total cholesterol (TC), triglycerides (TG), and free fatty acid (FFA) levels. At 20 weeks of age, all rats were randomly divided into two groups: a fenofibrate group (in which rats were gavaged with 300 mg/kg/day of fenofibrate) and a control group (gavaged with water). Fenofibrate treatment lasted 5 weeks. There were no significant changes in daily food intake, blood glucose, and plasma TG level with age. Body weight, plasma TC, and FFA levels were significantly increased with age. Fenofibrate significantly decreased plasma concentrations of TC and FFA, which had been increased with age. However, fenofibrate did not influence the plasma concentration of TG, which had not increased with age. These results suggest that fenofibrate might have a novel role in preventing age-related hypercholesterolemia in SD rats on a normal diet.
authors.affiliation: Department of Pharmacology, Dong-A University College of Medicine, Medical Science Research Center, Busan 602-714, Korea.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Mi-Hyang
authors.initials: MH
authors.lastname: Do
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Eunhui
authors.initials: E
authors.lastname: Seo
authors.forename: Mi-Kyoung
authors.initials: MK
authors.lastname: Park
authors.forename: Duk Kyu
authors.initials: DK
authors.lastname: Kim
authors.forename: Hye-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Su-Yeong
authors.initials: SY
authors.lastname: Seo
references.citation: J Toxicol Sci. 2009 Oct;34(4):377-87
references.pmid: 19652460
references.citation: Exp Gerontol. 2010 Feb;45(2):119-28
references.pmid: 19895880
references.citation: Arch Intern Med. 1999 Aug 9-23;159(15):1670-8
references.pmid: 10448768
references.citation: N Engl J Med. 1995 Feb 23;332(8):512-21
references.pmid: 7830734
references.citation: Curr Opin Chem Biol. 1997 Aug;1(2):235-41
references.pmid: 9667857
references.citation: J Clin Endocrinol Metab. 2004 Feb;89(2):463-78
references.pmid: 14764748
references.citation: Nature. 1990 Oct 18;347(6294):645-50
references.pmid: 2129546
references.citation: Biochem Biophys Res Commun. 2002 Aug 16;296(2):293-9
references.pmid: 12163016
references.citation: Biochem Biophys Res Commun. 2010 Mar 26;394(1):70-4
references.pmid: 20171169
references.citation: FEBS Lett. 2001 Feb 23;491(1-2):154-8
references.pmid: 11226439
references.citation: J Cell Biochem. 2006 Aug 1;98(5):1044-53
references.pmid: 16741953
references.citation: Heart Dis Stroke. 1992 Nov-Dec;1(6):357-65
references.pmid: 1344132
references.citation: J Intern Med. 1997 Oct;242(4):329-37
references.pmid: 9366812
references.citation: Diabetes Metab. 2000 May;26(3):184-91
references.pmid: 10880891
references.citation: Atherosclerosis. 2007 Jul;193(1):112-20
references.pmid: 16979646
references.citation: J Clin Invest. 1991 Feb;87(2):591-6
references.pmid: 1991842
references.citation: Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H1-9
references.pmid: 12623780
references.citation: Kardiol Pol. 2004 Jun;60(6):567-77
references.pmid: 15334157
references.citation: Biochem Biophys Res Commun. 2000 May 10;271(2):445-50
references.pmid: 10799317
references.citation: Clin Ther. 2002 Dec;24(12):2022-50
references.pmid: 12581543