Remarkable effect of phosphine on the reactivity of O,P-acetal--efficient substitution reaction of O,P-acetal.
The structure and electronic nature of the phosphine have a significant influence on not only the formation, but also the subsequent transformation of O,P-acetals. The O,P-acetals generated from tris(o-tolyl)phosphine [(o-tol)(3)P] underwent efficient substitution reactions with various nucleophiles.
Fujioka
Hiromichi
H
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. fujioka@phs.osaka-u.ac.jp
Goto
Akihiro
A
Otake
Kazuki
K
Kubo
Ozora
O
Yahata
Kenzo
K
Sawama
Yoshinari
Y
Maegawa
Tomohiro
T
D000080:Acetals / Q000737:chemistry*; D006868:Hydrolysis; D010720:Phosphines / Q000737:chemistry*
D000080:Acetals; D010720:Phosphines; C044646:phosphine