title: Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures.
abstract: We investigated the effects of exposure to maternal convulsive seizures in utero on the behavior of offspring. An epilepsy model was induced in female rats by administration of pilocarpine. Seizure frequency was evaluated for 60 days. The rats were then allowed to mate, and seizure frequency during pregnancy was recorded and compared with prepregnancy frequency. After birth, placentas of mothers were submitted for histopathological analysis. The behavior of the offspring was evaluated 3 months after birth. There was a decline in seizure frequency even though the placentas from epileptic mothers showed areas of ischemic infarction indicative of fetal hypoxia. Offspring of epileptic mothers manifested deficits in motor coordination in the rotarod test and increased immobility in the open-field test. No changes in anxiety and depression-like behaviors were observed. These results suggest that "in utero" exposure to maternal seizures can produce motor deficits in adult life, perhaps as a result of fetal hypoxia.
authors.affiliation: Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, Rua Botucatu 862, São Paulo, Brazil.
authors.forename: Daiana Correia
authors.initials: DC
authors.lastname: Lima
authors.forename: Tiago Gurgel do
authors.initials: TG
authors.lastname: Vale
authors.forename: Gustavo Adolfo
authors.initials: GA
authors.lastname: Arganãraz
authors.forename: Pedro Paulo Vasconcelos
authors.initials: PP
authors.lastname: Varella
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
authors.forename: Maria da Graça
authors.initials: Mda G
authors.lastname: Naffah-Mazzacoratti
authors.forename: Débora
authors.initials: D
authors.lastname: Amado
mesh_terms: D000818:Animals; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology*; D003863:Depression / Q000523:psychology; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology / Q000523:psychology*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010862:Pilocarpine; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000523:psychology*
chemical_list: D010862:Pilocarpine