Effect of ethanol on sleep-awake state in sleep-disturbed rats.
The present study was undertaken to investigate the effect of ethanol on the sleep-wake cycle in normal rats and sleep-disturbed rats. In normal rats, no significant difference was observed by ethanol in sleep latency, total awake time and total non-rapid eye movement (NREM) sleep time, except for total REM sleep time. On the other hand, in sleep-disturbed rats, ethanol at doses of 1 and 2 g/kg caused significant decreases in sleep latency and total wake time, and an increase in total NREM sleep time. In addition, ethanol showed a significant increase in delta activity in the sleep-disturbed model rat, different from triazolam. These results suggested that ethanol had not only a hypnotic but also a sleep-maintaining effect in sleep-disturbed rats at reasonable blood ethanol concentrations.
Obara
Yoshihito
Y
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
Tsutsui
Ryuki
R
Ishida
Takayuki
T
Kamei
Chiaki
C
D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use*; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D012895:Sleep, REM / Q000187:drug effects; D014229:Triazolam / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D014229:Triazolam; D000431:Ethanol