Cyclic spermidine alkaloids and flavone glycosides from Meehania fargesii.
The dried whole plant of Meehania fargesii (H. LéV.) C. Y. WU is utilized as an antipyretic and antidote for poison in China. Water soluble fractions, obtained from an 80% acetone extract of the whole plant, showed hyaluronidase inhibitory activity. From these fractions, hyaluronidase inhibitors were isolated along with two new spermidine alkaloids (meefarnines A and B), four new flavone glycosides (fargenins A-D), and 10 known compounds. The structure of each was elucidated by spectroscopic methods.
Murata
Toshihiro
T
Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. murata-t@tohoku-pharm.ac.jp
Miyase
Toshio
T
Yoshizaki
Fumihiko
F
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018514:Plant Structures / Q000737:chemistry*; D012995:Solubility; D013095:Spermidine / Q000737:chemistry* / Q000494:pharmacology; D014867:Water / Q000737:chemistry*
D000470:Alkaloids; D004791:Enzyme Inhibitors; D047309:Flavones; D006027:Glycosides; D014867:Water; D006821:Hyaluronoglucosaminidase; D013095:Spermidine