title: Optoacoustic imaging of the prostate: development toward image-guided biopsy.
abstract: Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion induced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold standard for guiding biopsy of the prostate. Although key structural features such as the urethra could be identified with both imaging techniques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood vessels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pressure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy.
authors.affiliation: Fairway Medical Technologies Inc., 710 North Post Oak Road, Suite 204, Houston, Texas 77024, USA.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Yaseen
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Ermilov
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Brecht
authors.forename: Richard
authors.initials: R
authors.lastname: Su
authors.forename: André
authors.initials: A
authors.lastname: Conjusteau
authors.forename: Matthew
authors.initials: M
authors.lastname: Fronheiser
authors.forename: Brent A
authors.initials: BA
authors.lastname: Bell
authors.forename: Massoud
authors.initials: M
authors.lastname: Motamedi
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Oraevsky
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000379:methods*; D017076:Computer-Aided Design; D004285:Dogs; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007834:Lasers; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014159:Transducers
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