Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression.
Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.
Mann
J J
JJ
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, USA. jjm@columbia.edu
Currier
D M
DM
D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D044127:Epigenesis, Genetic; D006801:Humans; D013315:Stress, Psychological / Q000235:genetics / Q000523:psychology*; D013405:Suicide / Q000523:psychology*
Mol Psychiatry. 2008 Aug;13(8):813-20
18180764
J Neurosci. 2006 Jun 14;26(24):6469-72
16775134
Ann N Y Acad Sci. 1997 Dec 29;836:106-34
9616796
Mol Psychiatry. 2002;7(1):118-22
11803458
Mol Psychiatry. 2008 Feb;13(2):131-46
17700575
Int J Neuropsychopharmacol. 2009 Nov;12(10):1327-35
19573266
Arch Gen Psychiatry. 2003 Jan;60(1):14-22
12511168
Nat Neurosci. 2007 Sep;10(9):1103-9
17726476
Arch Gen Psychiatry. 2008 Feb;65(2):190-200
18250257
Biol Psychiatry. 2009 Oct 1;66(7):681-5
19596121
Psychopharmacology (Berl). 2004 Nov;176(3-4):248-55
15173929
Neuropsychopharmacology. 2007 Sep;32(9):2046-52
17356577
Pharmacol Rev. 1991 Dec;43(4):425-73
1775506
Arch Suicide Res. 2007;11(1):17-40
17178640
Psychiatr Clin North Am. 2008 Jun;31(2):247-69
18439448
Ann N Y Acad Sci. 2004 Jun;1018:25-34
15240349
Int J Neuropsychopharmacol. 2006 Aug;9(4):465-74
15967058
Prog Brain Res. 2008;172:307-15
18772039
Psychiatr Clin North Am. 2008 Jun;31(2):223-35
18439446
Biol Psychiatry. 2004 Apr 1;55(7):733-8
15039002
Mol Psychiatry. 2003 Jul;8(7):646-53
12874600
Pharmacopsychiatry. 1995 Mar;28(2):45-50
7542785
Arch Suicide Res. 2007;11(1):3-16
17178639
Biol Psychiatry. 2001 Jun 15;49(12):1023-39
11430844
Nat Rev Neurosci. 2003 Oct;4(10):819-28
14523381
Wien Klin Wochenschr. 2007;119(15-16):463-75
17721766
Synapse. 2009 Jul;63(7):565-73
19288578
J Neurosci. 2005 Nov 23;25(47):11045-54
16306417
Biol Psychiatry. 2000 Mar 15;47(6):548-56
10715361