Efficacy of a new inactivated Chlamydophila felis vaccine in experimentally-infected cats.
A new inactivated and adjuvanted Chlamydophila felis vaccine was developed and its efficacy in cats was compared with that of commercially available inactivated and live vaccines. Two commercial vaccines conferred insufficient immunity on inoculated cats, as evaluated by antibody production and a challenge experiment, whereas cats administered the newly generated vaccine produced high-titre antibodies and acquired sufficient immunity. The cats immunised with the new vaccine revealed no or only mild clinical signs, and no chlamydiae were recovered from their tissue samples after exposure to a virulent C felis. However, they shed chlamydiae in their nasal and conjunctival secretions after challenge, as did those immunised with the commercial vaccines and the non-vaccinated controls. The newly developed vaccine caused no adverse reaction in the inoculated cats. These findings suggest that the new vaccine prepared here may be promising for practical use in controlling C felis infection in cats.
Masubuchi
Katsuo
K
Kyoto Biken Laboratories, Inc., 24-16 Makishima-cho, Uji-shi, Kyoto 611-0041, Japan. caninefeline@kyotobiken.co.jp
Wakatsuki
Akira
A
Iwamoto
Kayo
K
Takahashi
Takuo
T
Kokubu
Teruaki
T
Shimizu
Mitsugu
M
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000276:immunology*; D002371:Cat Diseases / Q000517:prevention & control*; D002415:Cats; D002689:Chlamydia / Q000302:isolation & purification; D023501:Chlamydophila / Q000276:immunology*; D023521:Chlamydophila Infections / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D008297:Male; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated
Can J Comp Med. 1980 Jul;44(3):244-51
6448682
J Vet Intern Med. 2003 Nov-Dec;17(6):799-807
14658715
J Am Vet Med Assoc. 1993 Aug 1;203(3):396-405
8257557
Vet Rec. 1983 Dec 3;113(23):535-6
6364542
J Vet Med Sci. 2000 Jul;62(7):801-3
10945306
J Am Vet Med Assoc. 1997 Jan 15;210(2):249-51
9018362
J Vet Med Sci. 2001 Aug;63(8):937-8
11558555
Vet Parasitol. 2005 Sep 5;132(1-2):75-80
15990233
J Vet Med Sci. 2002 Dec;64(12):1165-8
12520115
Can Vet J. 1992 Feb;33(2):134
17423950
Am J Vet Res. 1977 Sep;38(9):1361-3
921030
Avian Dis. 1993 Apr-Jun;37(2):459-66
8363510
Science. 1942 Nov 20;96(2499):475-6
17743467
J Feline Med Surg. 2006 Jun;8(3):207-11
16476560
Zentralbl Veterinarmed B. 1982 Dec;29(10):769-75
7164671
Infect Immun. 1987 Nov;55(11):2653-7
3666957
Microbiol Immunol. 1996;40(10):755-9
8981349
Vet Rec. 1984 Apr 7;114(14):344-6
6719790
J Am Vet Med Assoc. 1994 Nov 15;205(10):1425-9
7698923
Clin Tech Small Anim Pract. 2005 May;20(2):129-34
15948428
Aust Vet J. 1981 Nov;57(11):515-7
7342937
J Am Vet Med Assoc. 1998 Nov 15;213(10):1422-3
9828933
Microbiol Immunol. 2000;44(3):155-60
10789502
J Vet Med Sci. 1992 Aug;54(4):685-92
1391179
N Z Vet J. 1995 Oct;43(5):201-3
16031850