title: [Infective endocarditis in children without underlying heart disease: a retrospective study analyzing 11 cases].
abstract: The aim of our study was to determine the different characteristics of infective endocarditis in children without underlying heart disease. This was a descriptive, retrospective study including all cases of infective endocarditis without underlying heart disease occurring in children under 18 years of age, hospitalized at the Timone Children's Hospital in Marseille, France, between 1997 and 2008. The clinical, microbiological, and echocardiography data; treatment; and outcome were reviewed for each case. Over an 11-year period, 26 children were hospitalized with infective endocarditis. Eleven children (7 boys) had no underlying heart disease (42 %). Their mean age was 8 years and 3 months. Underlying conditions including neoplasm, preterm birth, and central venous catheter were found in 6 cases. A heart murmur was observed in 82 % of the children. A microorganism was isolated in 10 children (91 %). Staphylococcus aureus was the most common agent (45 %), followed by fungi (18 %). Echocardiography detected cardiac complications in 7 cases (64 %). Ninety-one percent of the children received intravenous antibiotics for a mean duration of 45 days. Eighty-two percent of our patients required surgical intervention. In our series, 91 % of the patients met the modified Duke criteria defining infective endocarditis. In-hospital mortality was 11 %. Embolic complications were seen in 5 cases (45 %), patients whose cultures yielded S. aureus or fungal organisms were more likely to present complications. Infective endocarditis without heart disease has particular features that differ from those of congenital heart disease. This diagnosis must be considered when predisposing factors are present.
authors.affiliation: Unité de médecine infantile, CHU Timone-Enfants, 264 rue Saint-Pierre, Marseille cedex 5, France.
authors.forename: S
authors.initials: S
authors.lastname: Le Guillou
authors.forename: J-P
authors.initials: JP
authors.lastname: Casalta
authors.forename: A
authors.initials: A
authors.lastname: Fraisse
authors.forename: B
authors.initials: B
authors.lastname: Kreitmann
authors.forename: B
authors.initials: B
authors.lastname: Chabrol
authors.forename: J-C
authors.initials: JC
authors.lastname: Dubus
authors.forename: E
authors.initials: E
authors.lastname: Bosdure
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D005260:Female; D006331:Heart Diseases / Q000150:complications*; D006337:Heart Murmurs / Q000150:complications; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein