title: Pro/Anti-inflammatory cytokine imbalance in postischemic left ventricular remodeling.
abstract: OBJECTIVE
  Cytokines play an important role in left ventricular remodeling consequent to myocardial ischemia. The aim of this study was to correlate cytokine production and lymphocyte apoptosis to post-ischemic left ventricular remodeling in patients affected by acute myocardial infarction (AMI) undergoing primary cutaneous angioplasty (PCI).
  
  
  METHODS
  In 40 patients, affected by AMI and undergoing PCI, we evaluated peripheral blood mononuclear cells (PBMCs), tumor necrosis factor-alpha (TNF-alpha) and interleukin 10 (IL10) production and apoptosis on day 1, day 3, day 7, 1 month and 6 months after PCI. Patients were divided into two subgroups of remodeling or not remodeling by echocardiographic criteria.
  
  
  RESULTS
  In the subgroup of remodeling patients, at each timepoint TNF-alpha production was increased significantly in comparison with the subgroup of not remodeling patients. IL10 production was statistically lower in remodeling subjects than in not remodeling ones 1 and 6 months after reperfusion. There were no differences between the two groups as regards lymphomonocyte apoptosis.
  
  
  CONCLUSIONS
  We found an increased production of pro-inflammatory cytokine TNF-alpha and a corresponding decrease of anti-inflammatory/regulatory cytokine IL10 in remodeling patients and we concluded that this cytokine imbalance resulted in pro-inflammatory effects which might contribute to the progression of left ventricular remodeling.
authors.affiliation: Division of Internal Medicine, Department of Clinical Medicine and Immunology, University of Siena, V. le Bracci, 53100 Siena, Italy.
authors.forename: Anna Laura
authors.initials: AL
authors.lastname: Pasqui
authors.forename: Pasqui Anna
authors.initials: PA
authors.lastname: Laura
authors.forename: Michela
authors.initials: M
authors.lastname: Di Renzo
authors.forename: Di Renzo
authors.initials: DR
authors.lastname: Michela
authors.forename: Silvia
authors.initials: S
authors.lastname: Maffei
authors.forename: Maffei
authors.initials: M
authors.lastname: Silvia
authors.forename: Marcello
authors.initials: M
authors.lastname: Pastorelli
authors.forename: Pastorelli
authors.initials: P
authors.lastname: Marcello
authors.forename: Gerarda
authors.initials: G
authors.lastname: Pompella
authors.forename: Pompella
authors.initials: P
authors.lastname: Gerarda
authors.forename: Alberto
authors.initials: A
authors.lastname: Auteri
authors.forename: Auteri
authors.initials: A
authors.lastname: Alberto
authors.forename: Luca
authors.initials: L
authors.lastname: Puccetti
authors.forename: Puccetti
authors.initials: P
authors.lastname: Luca
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D004452:Echocardiography; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D009203:Myocardial Infarction / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D020257:Ventricular Remodeling / Q000276:immunology*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
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