Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.
Sherborne
Amy L
AL
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Hosking
Fay J
FJ
Prasad
Rashmi B
RB
Kumar
Rajiv
R
Koehler
Rolf
R
Vijayakrishnan
Jayaram
J
Papaemmanuil
Elli
E
Bartram
Claus R
CR
Stanulla
Martin
M
Schrappe
Martin
M
Gast
Andreas
A
Dobbins
Sara E
SE
Ma
Yussanne
Y
Sheridan
Eamonn
E
Taylor
Malcolm
M
Kinsey
Sally E
SE
Lightfoot
Tracey
T
Roman
Eve
E
Irving
Julie A E
JA
Allan
James M
JM
Moorman
Anthony V
AV
Harrison
Christine J
CJ
Tomlinson
Ian P
IP
Richards
Sue
S
Zimmermann
Martin
M
Szalai
Csaba
C
Semsei
Agnes F
AF
Erdelyi
Daniel J
DJ
Krajinovic
Maja
M
Sinnett
Daniel
D
Healy
Jasmine
J
Gonzalez Neira
Anna
A
Kawamata
Norihiko
N
Ogawa
Seishi
S
Koeffler
H Phillip
HP
Hemminki
Kari
K
Greaves
Mel
M
Houlston
Richard S
RS
D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
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