Fast repair of DNA radicals.
This tutorial review highlights the mechanism of a novel non-enzymatic fast repair of DNA damage, which refers exclusively to repair DNA radicals including DNA-OH* adducts, DNA radical cations and anions by various endogenous, natural and synthetic compounds. The repair rate constants are as high as 10(9) M(-1) s(-1). In cells, when the enzymatic repair system was inhibited or before the enzymatic repair mechanism was initiated, DNA oxidative damage was significantly reduced by natural polyphenols. This decrease of DNA damage is assigned to the fast repair. Fast repair takes place through an electron transfer process, and docking of polyphenol into the DNA minor groove could be the essential step.
Zheng
Rongliang
R
School of Life Sciences, Lanzhou University, Lanzhou, 730000, China. zhengrl@lzu.edu.cn
Shi
Yimin
Y
Jia
Zhongjian
Z
Zhao
Chenyang
C
Zhang
Qi
Q
Tan
Xiaorong
X
D002477:Cells / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry* / Q000378:metabolism*; D004260:DNA Repair; D004579:Electron Transport; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D013997:Time Factors
D018736:DNA Adducts; D005609:Free Radicals