Hypoxia, HIFs and bone development.
Oxygen is not only an obviously important substrate, but it is also a regulatory signal that controls expression of a specific genetic program. Crucial mediator of the adaptive response of cells to hypoxia is the family of Hypoxia-Inducible Transcription Factors (HIFs).The fetal growth plate, which is an avascular structure of mesenchymal origin, has a unique out-in gradient of oxygenation. HIF-1alpha is necessary for chondrogenesis in vivo by controlling a complex homeostatic response that allows chondrocytes to survive and differentiate in a hypoxic environment. Moreover, HIFs are also essential in osteogenesis and joint development. This brief Perspective summarizes the critical role of HIFs in endochondral bone development.
Araldi
Elisa
E
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Schipani
Ernestina
E
D000818:Animals; D001846:Bone Development / Q000502:physiology*; D015687:Cell Hypoxia; D020219:Chondrogenesis / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D007596:Joints / Q000378:metabolism; D008954:Models, Biological
D051793:Hypoxia-Inducible Factor 1
Osteoarthritis Cartilage. 2004 Apr;12(4):336-45
15023385
Dev Cell. 2005 Nov;9(5):617-28
16256737
J Neurosci. 2000 Oct 1;20(19):7377-83
11007896
Arthritis Rheum. 2009 May;60(5):1406-15
19404942
Prog Biophys Mol Biol. 2006 Jul;91(3):249-86
16137743
Development. 2004 May;131(10):2497-508
15128677
Dev Cell. 2001 Aug;1(2):277-90
11702786
FEBS Lett. 2009 Mar 18;583(6):1006-10
19233176
Clin Cancer Res. 2008 Mar 1;14(5):1340-8
18316553
Cell. 1997 May 30;89(5):747-54
9182762
Mol Cell Biol. 2005 Jun;25(11):4565-78
15899860
Cancer Res. 2005 Apr 15;65(8):3299-306
15833863
Genes Dev. 2004 Sep 15;18(18):2183-94
15371333
Proc Natl Acad Sci U S A. 2002 May 14;99(10):7021-6
12011461
Mol Cell Biol. 2000 Jun;20(11):4149-58
10805756
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1949-54
18238902
J Cell Biol. 2007 May 7;177(3):451-64
17470636
Genes Dev. 2001 Oct 15;15(20):2675-86
11641274
Dev Cell. 2002 Mar;2(3):331-41
11879638
EMBO J. 2010 Jan 20;29(2):424-41
20010698
Mol Cell Biol. 2005 Apr;25(8):3040-55
15798192
Mol Cell. 2009 Sep 24;35(6):737-8
19782023
Nat Genet. 2003 Dec;35(4):331-40
14608355
Autophagy. 2008 Feb;4(2):195-204
18059169
J Biol Chem. 2008 Apr 18;283(16):10892-903
18281291
Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):539-46
16144691
J Biol Chem. 2009 Apr 24;284(17):11326-35
19251704
J Biol Chem. 2003 Aug 15;278(33):30772-80
12788921
Genes Dev. 2002 Nov 1;16(21):2813-28
12414734
Development. 2004 May;131(9):2161-71
15073147
J Cell Mol Med. 2008 Sep-Oct;12(5A):1426-31
18624759
Cancer Cell. 2009 Jan 6;15(1):35-44
19111879
Nat Rev Mol Cell Biol. 2008 Apr;9(4):285-96
18285802
J Biol Chem. 2002 Sep 6;277(36):32405-8
12119283
Cell Cycle. 2009 Sep 1;8(17):2756-68
19652553
Birth Defects Res C Embryo Today. 2005 Sep;75(3):200-12
16187326
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61
16461460
J Cell Biochem. 2010 Jan 1;109(1):196-204
19899108
Nature. 2003 May 15;423(6937):332-6
12748651
Plast Reconstr Surg. 1999 Sep;104(3):738-47
10456527
Autophagy. 2007 May-Jun;3(3):207-14
17224629
FASEB J. 2003 Feb;17(2):271-3
12490539
Dev Biol. 2009 Aug 15;332(2):196-211
19464280
Mol Cell Biol. 2007 Mar;27(5):1859-67
17194750
J Clin Invest. 2007 Jun;117(6):1616-26
17549257
Bone. 2005 Sep;37(3):313-22
16023419
J Biol Chem. 2004 Oct 1;279(40):41966-74
15280364
Science. 2001 Apr 20;292(5516):464-8
11292862
Development. 2002 Apr;129(8):1893-904
11934855
Mol Cell Biol. 2003 Jan;23(1):359-69
12482987
Cell Death Differ. 2008 Apr;15(4):619-20
18345017
Biochem Biophys Res Commun. 2008 Oct 24;375(3):287-91
18680722
Cancer Res. 2008 Jul 15;68(14):5540-5
18632605
Genes Dev. 2001 Nov 1;15(21):2865-76
11691837
J Cell Biol. 2005 May 23;169(4):681-91
15911882
J Biol Chem. 2006 Oct 13;281(41):30678-83
16926163
EMBO J. 2004 May 5;23(9):1949-56
15071503
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):686-91
18184809
Biochem Biophys Res Commun. 2005 Mar 18;328(3):658-65
15694399
Genes Dev. 2002 Jun 15;16(12):1466-71
12080085
Nature. 2003 May 15;423(6937):316-8
12748648
J Orthop Res. 2000 Sep;18(5):698-705
11117289
J Biol Chem. 2009 Oct 23;284(43):29514-25
19706597
Mol Cell Biol. 2007 Sep;27(17):6229-42
17576813
Clin Orthop Relat Res. 1990 Jan;(250):8-26
2403497
Ann N Y Acad Sci. 2007 Nov;1117:26-39
18056035
Cell. 1998 May 1;93(3):411-22
9590175
Ann N Y Acad Sci. 2003 May;995:183-90
12814950
J Neurosci. 2000 Oct 1;20(19):7370-6
11007895
J Biol Chem. 2008 Feb 22;283(8):4778-86
18077449
Mol Cell Biol. 2005 Dec;25(23):10479-91
16287860
Cell. 2007 Oct 19;131(2):324-36
17956733
Trends Mol Med. 2006 Apr;12(4):141-3
16513423
Science. 2001 Nov 9;294(5545):1337-40
11598268
Mol Cell Biol. 2010 Jan;30(1):344-53
19858293
Mol Cell Biol. 2003 Dec;23(24):9361-74
14645546
J Bone Miner Res. 2008 May;23(5):596-609
18433297
Br J Haematol. 2008 May;141(3):325-34
18410568
Cell. 2005 Jan 14;120(1):15-20
15652477
Cell Cycle. 2004 Jul;3(7):853-4
15190211
Nature. 2006 Apr 27;440(7088):1222-6
16642001
Cardiovasc Res. 2003 Dec 1;60(3):569-79
14659802
Cell. 2003 Dec 26;115(7):787-98
14697198
Cell Cycle. 2006 Mar;5(5):495-8
16552177
J Biol Chem. 2007 May 4;282(18):13672-9
17360716
J Cell Physiol. 2007 Feb;210(2):279-89
17096367
PLoS One. 2006 Dec 27;1:e116
17205120
Autophagy. 2006 Jul-Sep;2(3):215-6
16874108
Science. 2001 Apr 20;292(5516):468-72
11292861
Nat Rev Cancer. 2008 Nov;8(11):851-64
18846101
Gene Regul Syst Bio. 2008 Apr 22;2:177-91
19787082
Mol Cell Biol. 2005 Jul;25(13):5675-86
15964822
Mol Cell Biol. 1992 Dec;12(12):5447-54
1448077
Dev Cell. 2009 Dec;17(6):755-73
20059947
Science. 2002 Feb 1;295(5556):858-61
11823643
Cell Death Differ. 2008 Apr;15(4):672-7
18188166
Development. 2009 Apr;136(8):1263-72
19261698
Pediatr Endocrinol Rev. 2003 Sep;1(1):2-8
16437008
Development. 2007 Nov;134(21):3917-28
17913788
Biochem J. 2008 Dec 15;416(3):387-94
18713068
Arthritis Rheum. 2007 Oct;56(10):3297-306
17907154
J Biol Chem. 2004 Sep 17;279(38):40007-16
15263007
Bone. 2009 Jan;44(1):24-31
18835464
Development. 2008 Nov;135(21):3587-97
18832389
Pflugers Arch. 2008 Jan;455(4):563-73
17849146
Nat Med. 1999 Jun;5(6):623-8
10371499
Circ Res. 2009 Apr 10;104(7):879-86
19265035
Cell Death Differ. 2008 Oct;15(10):1572-81
18551130
Ann N Y Acad Sci. 2007 Nov;1116:149-64
18083926
EMBO J. 1998 Sep 1;17(17):5085-94
9724644
Biochem Biophys Res Commun. 2008 Aug 8;372(4):892-7
18538129