Evaluation of flavoglaucin, its derivatives and pyranonigrins produced by molds used in fermented foods for inhibiting tumor promotion.
Flavoglaucin, its derivatives, and pyranonigrins, which are antioxidants produced by the molds used in fermented foods, were examined for their inhibition of tumor promotion by the Epstein-Barr virus early antigen activation test. Flavoglaucin and its derivatives exhibited high activity. Flavoglaucin and such a derivative as isodihydroauroglaucin inhibited mouse skin tumor promotion in a two-stage carcinogenesis test and appear to be antitumor promoters.
Miyake
Yoshiaki
Y
Faculty of Human Wellness, Tokaigakuen University, Nagoya, Japan. miyakeyo@tokaigakuen-u.ac.jp
Ito
Chihiro
C
Tokuda
Harukuni
H
Osawa
Toshihiko
T
Itoigawa
Masataka
M
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D005285:Fermentation; D005516:Food Microbiology; D005658:Fungi / Q000378:metabolism*; D005841:Gentisates / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000276:immunology; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D011753:Pyrones / Q000378:metabolism / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000821:virology
D000956:Antigens, Viral; D000975:Antioxidants; D005841:Gentisates; D011753:Pyrones; C005001:flavoglaucin