title: [Glaucoma and corneal transplantation].
abstract: Glaucoma and corneal disorders are often associated and are of diagnostic, therapeutic and prognostic relevance for each other. Glaucoma is already present in approximately 15% of eyes prior to keratoplasty, whereas in addition approximately 15% of cases are diagnosed following corneal transplantation. Corneal opacities, surface irregularities and pachymetric deviations from the norm can have a negative impact on tonometry, perimetry and morphological glaucoma diagnosis. Digital and intracameral tonometry as well as flash VEP to determine the visual potential can be helpful in this setting. Increased intraocular pressure (IOP), long-term application of antiglaucomatous medication or the use of antimetabolites in glaucoma surgery can all induce keratopathy. Therefore, intraocular pressure should be regulated prior to corneal transplantation. Risk factors for the evolution of glaucoma following corneal transplantation are the specific indication and surgical technique (e. g. combined corneal and cataract/vitreoretinal surgery), as well as postoperative steroid application and chamber angle synechiae. Unpreserved glaucoma medication without pro-inflammatory effects should be preferred following keratoplasty. In the long term surgery to control IOP is required in approximately 25% of eyes. The wider use of lamellar techniques for corneal transplantation is likely to reduce the incidence of secondary glaucoma.
authors.affiliation: Universitätsaugenklinik, Julius-Maximilians-Universität Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland. g.geerling@klinik.uni-wuerzburg.de
authors.forename: G
authors.initials: G
authors.lastname: Geerling
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Zierhut
authors.forename: T
authors.initials: T
authors.lastname: Klink
mesh_terms: D003316:Corneal Diseases / Q000209:etiology* / Q000517:prevention & control*; D016039:Corneal Transplantation / Q000009:adverse effects* / Q000379:methods*; D005901:Glaucoma / Q000150:complications* / Q000601:surgery*; D006801:Humans; D018570:Risk Assessment
references.citation: Surv Ophthalmol. 1990 Mar-Apr;34(5):325-56
references.pmid: 2183380
references.citation: J Glaucoma. 2009 Mar;18(3):197-200
references.pmid: 19295371
references.citation: Nippon Ganka Gakkai Zasshi. 2009 May;113(5):576-82
references.pmid: 19489448
references.citation: Graefes Arch Clin Exp Ophthalmol. 2001 Nov;239(11):809-14
references.pmid: 11789860
references.citation: Ophthalmology. 1987 Jul;94(7):871-4
references.pmid: 3309771
references.citation: Klin Monbl Augenheilkd. 2010 Jun;227(6):460-6
references.pmid: 20560099
references.citation: J Glaucoma. 1998 Aug;7(4):266-9
references.pmid: 9713785
references.citation: Br J Ophthalmol. 2000 Jul;84(7):714-7
references.pmid: 10873980
references.citation: Ophthalmologica. 2002 May-Jun;216(3):175-9
references.pmid: 12065853
references.citation: Ophthalmology. 2007 Dec;114(12):2281-6
references.pmid: 18054642
references.citation: Acta Ophthalmol Scand. 2007 Mar;85(2):209-12
references.pmid: 17305736
references.citation: Am J Ophthalmol. 1981 Sep;92(3):372-7
references.pmid: 7027797
references.citation: Exp Eye Res. 2008 Feb;86(2):394-402
references.pmid: 18187130
references.citation: Am J Ophthalmol. 2007 Jul;144(1):104-108
references.pmid: 17601429
references.citation: Eye (Lond). 1988;2 ( Pt 5):583-90
references.pmid: 3076870
references.citation: Curr Opin Ophthalmol. 2010 Mar;21(2):144-9
references.pmid: 20040871
references.citation: Ophthalmic Surg. 1980 Oct;11(10):701-7
references.pmid: 7005797
references.citation: Ophthalmology. 1992 Jul;99(7):1082-8
references.pmid: 1495787
references.citation: Cornea. 2009 Oct;28(9):1003-8
references.pmid: 19724212
references.citation: Klin Monbl Augenheilkd. 2005 Aug;222(8):612-4
references.pmid: 16118740
references.citation: Cornea. 2002 Nov;21(8):759-65
references.pmid: 12410031
references.citation: Cornea. 2009 Aug;28(7):759-64
references.pmid: 19574912
references.citation: Clin Exp Ophthalmol. 2008 Mar;36(2):142-7
references.pmid: 18352870
references.citation: Cornea. 1997 May;16(3):284-8
references.pmid: 9143799
references.citation: Curr Eye Res. 2005 Jul;30(7):569-74
references.pmid: 16020291
references.citation: Ophthalmologe. 2006 Sep;103(9):815-23; quiz 824-5
references.pmid: 16924450
references.citation: Arch Soc Esp Oftalmol. 2008 Apr;83(4):257-61
references.pmid: 18373299
references.citation: Cornea. 2009 May;28(4):385-94
references.pmid: 19411956
references.citation: Klin Monbl Augenheilkd. 2010 Nov;227(11):887-91
references.pmid: 21077021
references.citation: Am J Ophthalmol. 2006 Jun;141(6):1129-30
references.pmid: 16765685
references.citation: Arch Ophthalmol. 2004 Jul;122(7):1063-6
references.pmid: 15249377
references.citation: Am J Ophthalmol. 2000 Sep;130(3):287-91
references.pmid: 11020406
references.citation: Int Ophthalmol. 2008 Jun;28(3):191-207
references.pmid: 18431550
references.citation: Arch Ophthalmol. 1988 Feb;106(2):185-8
references.pmid: 3277605
references.citation: Cornea. 2010 Oct;29(10):1195-8
references.pmid: 20595891
references.citation: Trans Am Acad Ophthalmol Otolaryngol. 1974 Mar-Apr;78(2):OP352-64
references.pmid: 4596445
references.citation: Ophthalmology. 1982 Mar;89(3):242-6
references.pmid: 7045764
references.citation: Surv Ophthalmol. 2009 Mar-Apr;54(2):245-71
references.pmid: 19298903
references.citation: J Pediatr Ophthalmol Strabismus. 2005 Jan-Feb;42(1):34-44
references.pmid: 15724897
references.citation: Cornea. 2007 Oct;26(9):1060-6
references.pmid: 17893534
references.citation: Cornea. 2002 May;21(4):368-73
references.pmid: 11973385
references.citation: Ophthalmology. 1998 Aug;105(8):1550-6
references.pmid: 9709773
references.citation: Cornea. 2004 Jul;23(5):490-6
references.pmid: 15220734
references.citation: Curr Opin Ophthalmol. 2009 Mar;20(2):131-6
references.pmid: 19240546
references.citation: Ophthalmology. 2006 Sep;113(9):1633-8
references.pmid: 16828503
references.citation: Am J Ophthalmol. 1999 Apr;127(4):403-6
references.pmid: 10218692
references.citation: Invest Ophthalmol Vis Sci. 1992 Feb;33(2):416-23
references.pmid: 1740374
references.citation: J Glaucoma. 2007 May;16(3):324-8
references.pmid: 17438428
references.citation: Cornea. 1997 May;16(3):314-8
references.pmid: 9143804
references.citation: Klin Monbl Augenheilkd. 1998 Apr;212(4):203-6
references.pmid: 9644665
references.citation: Graefes Arch Clin Exp Ophthalmol. 1997 Sep;235(9):553-7
references.pmid: 9342604
references.citation: J Glaucoma. 2010 Mar;19(3):219-20
references.pmid: 19661823
references.citation: Retina. 1990;10 Suppl 1:S20-34
references.pmid: 2191380
references.citation: Ophthalmologe. 2009 Jun;106(6):531-5
references.pmid: 18670779
references.citation: Ophthalmologica. 2000 Sep-Oct;214(5):332-6
references.pmid: 10965246
references.citation: Ophthalmology. 2001 Nov;108(11):1986-91
references.pmid: 11713066
references.citation: Am J Ophthalmol. 1978 Jul;86(1):97-100
references.pmid: 354399
references.citation: J AAPOS. 2008 Feb;12(1):33-9
references.pmid: 17942353
references.citation: Graefes Arch Clin Exp Ophthalmol. 2010 Feb;248(2):237-42
references.pmid: 19936776
references.citation: Klin Monbl Augenheilkd. 1996 Aug-Sep;209(2-3):117-24
references.pmid: 8992071
references.citation: Cornea. 2009 Oct;28(9):959-62
references.pmid: 19724221
references.citation: Aust N Z J Ophthalmol. 1998 Nov;26(4):305-9
references.pmid: 9843258
references.citation: J Ocul Pharmacol Ther. 2009 Oct;25(5):459-62
references.pmid: 19857108
references.citation: Ophthalmology. 1982 Jun;89(6):596-9
references.pmid: 7122040
references.citation: Ophthalmologe. 2005 Apr;102(4):387-92
references.pmid: 15365747
references.citation: Ophthalmologe. 2000 Aug;97(8):552-6
references.pmid: 10994332
references.citation: Ophthalmologe. 2008 Jun;105(6):557-62
references.pmid: 18214492
references.citation: Fortschr Ophthalmol. 1991;88(2):118-20
references.pmid: 1855725
references.citation: Invest Ophthalmol Vis Sci. 2001 Apr;42(5):948-56
references.pmid: 11274071
references.citation: Eye (Lond). 2004 Jul;18(7):703-8
references.pmid: 14739919
references.citation: Trans Am Ophthalmol Soc. 1989;87:79-91; discussion 91-3
references.pmid: 2562533
references.citation: Ophthalmology. 1999 Mar;106(3):556-63
references.pmid: 10080214
references.citation: Ophthalmologe. 2005 Dec;102(12):1140-8, 1150-1
references.pmid: 16283187
references.citation: J Glaucoma. 2002 Jun;11(3):244-52
references.pmid: 12140403
references.citation: Am J Ophthalmol. 2007 Jan;143(1):23-31
references.pmid: 17054896
references.citation: Cornea. 1992 Sep;11(5):427-32
references.pmid: 1424672
references.citation: Ophthalmology. 2009 Sep;116(9):1644-50
references.pmid: 19643499
references.citation: Ophthalmology. 2009 Sep;116(9):1818-30
references.pmid: 19643492
references.citation: Ophthalmology. 1984 Jun;91(6):558-63
references.pmid: 6462621
references.citation: Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2444-50
references.pmid: 15980234
references.citation: Arch Ophthalmol. 1979 Nov;97(11):2139-40
references.pmid: 508182
references.citation: Am J Ophthalmol. 1969 Nov;68(5):835-44
references.pmid: 4900892