title: Highly enantioselective alpha-chlorination of cyclic beta-ketoesters catalyzed by N,N'-dioxide using NCS as the chlorine source.
abstract: A simple and highly efficient N,N'-dioxide organocatalyst system was developed for the asymmetric alpha-chlorination of cyclic beta-ketoesters using easily available NCS as the chlorine source to provide a series of optically active alpha-chloro-beta-ketoesters in excellent yields with 90-98% ee.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Cai
authors.forename: Wentao
authors.initials: W
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Shen
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Hu
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D002384:Catalysis; D002713:Chlorine / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D054879:Halogenation; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004952:Esters; D007659:Ketones; D002713:Chlorine