title: A study of East Timor variability using the SNPforID 52-plex SNP panel.
abstract: A set of 52 autosomal single nucleotide polymorphism (SNP) loci was analyzed in 46 unrelated individuals from the East Timor population using the forensic assay previously described by Sanchez et al. (2006) [J.J. Sanchez, C. Phillips, C. Børsting, K. Balogh, M. Bogus, M. Fondevila, C.D. Harrison, E. Musgrave-Brown, A. Salas, D. Syndercombe Court, PM. Schneider, A. Carracedo, N. Morling, A multiplex assay with 52 single nucleotide polymorphisms for human identification, Electrophoresis 27 (2006) 1713-1724]. Allele frequencies are presented for the 52 SNPs with all loci in Hardy-Weinberg equilibrium for the study population. Comparison with African, European, East Asian and Oceanian populations of the CEPH human genome diversity panel (CEPH-HGDP) revealed significant differences in allele frequency distributions between East Timor and each of the above population groups. Statistical parameters measuring forensic informativeness were also calculated and the values obtained reached comparable levels to those previously described for the other global population groups. This is the first study of variability in these SNPs in an Oceanian population outside of the CEPH-HGDP.
authors.affiliation: Forensic Genetics Department, University of Santiago de Compostela, Hospital Clínico Universitario, Galicia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.forename: C
authors.initials: C
authors.lastname: Phillips
authors.forename: M
authors.initials: M
authors.lastname: Fondevila
authors.forename: L
authors.initials: L
authors.lastname: Porras-Hurtado
authors.forename: A
authors.initials: A
authors.lastname: Carracedo
authors.forename: L
authors.initials: L
authors.lastname: Souto
authors.forename: M V
authors.initials: MV
authors.lastname: Lareu
mesh_terms: D044383:Black People / Q000235:genetics; D016172:DNA Fingerprinting / Q000379:methods; D005202:Asia, Eastern; D053803:Forensic Genetics / Q000379:methods* / Q000706:statistics & numerical data; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population / Q000379:methods* / Q000706:statistics & numerical data; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D044468:Native Hawaiian or Pacific Islander / Q000235:genetics; D010334:Paternity; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D049648:Timor-Leste; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers