Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection.
Arginase activity has been related to leishmaniasis development, thus we studied the constitutive and insulin-like growth factor (IGF) I-induced arginase activity of Leishmania (Viannia) braziliensis isolates from patients with different clinical forms of American tegumentary leishmaniasis (ATL). Isolates from mucosal leishmaniasis presented higher basal levels of arginase activity than isolates from other clinical forms of ATL. Isolates from disseminated leishmaniasis that present mucosal lesion in some cases reached the arginase activity similar to that of isolates from mucosal leishmaniasis upon IGF-I stimulation. Differences in arginase activity may influence disease outcomes such as evolution to mucosal lesion in patients with L. (V.) braziliensis infection.
Vendrame
Célia M V
CM
Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar n degrees 470, prédio II, 4 degrees andar, CEP 05403-000, São Paulo, SP, Brazil.
Souza
Luana D
LD
Carvalho
Márcia D T
MD
Salgado
Kátia
K
Carvalho
Edgar M
EM
Goto
Hiro
H
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D004586:Electrophoresis / Q000379:methods; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007892:Leishmania braziliensis / Q000201:enzymology*; D016773:Leishmaniasis, Cutaneous / Q000201:enzymology* / Q000453:epidemiology
D007334:Insulin-Like Growth Factor I; D001119:Arginase