Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates.
A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3.
Kamal
Ahmed
A
Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India. ahmedkamal@iict.res.in
Vijaya Bharathi
E
E
Janaki Ramaiah
M
M
Surendranadha Reddy
J
J
Dastagiri
D
D
Viswanath
A
A
Sultana
Farheen
F
Pushpavalli
S N C V L
SN
Pal-Bhadra
Manika
M
Juvekar
Aarti
A
Sen
Subrata
S
Zingde
Surekha
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis; D001569:Benzodiazepines / Q000737:chemistry*; D053148:Caspase 3 / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D006801:Humans; D011758:Pyrroles / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011758:Pyrroles; D016159:Tumor Suppressor Protein p53; D062367:ortho-Aminobenzoates; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines; D053148:Caspase 3; C000219:anthranilamide