Saturation effect in functional photoacoustic imaging.
We investigate the saturation effect, which describes the violation of the linearity between the measured photoacoustic amplitude and the object's optical absorption coefficient in functional photoacoustic imaging when the optical absorption in the object increases. We model the optical energy deposition and photoacoustic signal generation and detection in a semi-infinite optical absorbing object. Experiments are carried out by measuring photoacoustic signals generated from an ink-filled plastic tube. The saturation effect is studied by varying the optical absorption coefficient in the model and the ink concentration in the photoacoustic experiments. By changing the center frequency of the ultrasonic detector, the requirement to minimize the saturation effect in functional photoacoustic imaging is established.
Wang
Jing
J
University of Wisconsin-Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer Street, Milwaukee, Wisconsin 53201, USA.
Liu
Tan
T
Jiao
Shuliang
S
Chen
Ruimin
R
Zhou
Qifa
Q
Shung
K Kirk
KK
Wang
Lihong V
LV
Zhang
Hao F
HF
D000465:Algorithms; D016477:Artifacts; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
Phys Med Biol. 2007 Mar 7;52(5):1349-61
17301459
Nat Biotechnol. 2006 Jul;24(7):848-51
16823374
Phys Rev Lett. 2001 Apr 16;86(16):3550-3
11328020
IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar;54(3):668-75
17375836
Nat Protoc. 2007;2(4):797-804
17446879
Phys Med Biol. 2007 Jan 7;52(1):141-68
17183133
IEEE Trans Ultrason Ferroelectr Freq Control. 2008;55(6):1394-9
18599429
Nat Biotechnol. 2003 Jul;21(7):803-6
12808463
Phys Med Biol. 2008 Nov 7;53(21):6167-77
18854608