Redox biochemistry of hydrogen sulfide.
H(2)S, the most recently discovered gasotransmitter, might in fact be the evolutionary matriarch of this family, being both ancient and highly reduced. Disruption of gamma-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H(2)S production in the vasculature. However, patients with inherited deficiency in gamma-cystathionase apparently do not present vascular pathology. A mitochondrial pathway disposes sulfide and couples it to oxidative phosphorylation while also exposing cytochrome c oxidase to this metabolic poison. This report focuses on the biochemistry of H(2)S biogenesis and clearance, on the molecular mechanisms of its action, and on its varied biological effects.
Kabil
Omer
O
Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.
Banerjee
Ruma
R
D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D010084:Oxidation-Reduction
D006862:Hydrogen Sulfide
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