title: [Clinical and morphological characteristics and some mechanisms of portal gastroduodenopathy in liver cirrhosis].
abstract: We have found out the clinical presentations and peculiarities of endoscopic and morphologic view of pathologies of mucous membrane of gastroduodenal zone caused by liver cirrhosis. We have examined 74 patients with liver cirrhosis of viral and nonviral etiology using the clinical, endoscopic, morphologic and immunohistochemical methods.We have found that during liver cirrhosis morphometric rates of epithelial cells of mucous coat of stomach that produce somatostatin and endothelin-1 decrease and morphometric rates of epithelial cells that produce nitrogen oxide synthase increase. We have also found out that during liver cirrhosis proliferate activity decrease and apoptosis of epithelial cell of mucous coat of stomach increase.
authors.forename: I V
authors.initials: IV
authors.lastname: Kozlova
authors.forename: M V
authors.initials: MV
authors.lastname: Safonova
mesh_terms: D000328:Adult; D017209:Apoptosis; D049109:Cell Proliferation; D004378:Duodenal Diseases / Q000150:complications / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D019332:Endothelin-1 / Q000378:metabolism; D019858:Enteroendocrine Cells / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000378:metabolism; D012720:Severity of Illness Index; D013004:Somatostatin / Q000378:metabolism; D013272:Stomach Diseases / Q000150:complications / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*
chemical_list: D019332:Endothelin-1; D013004:Somatostatin; D019001:Nitric Oxide Synthase