5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.
The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.
Noro
Magali
M
Fonds de la Recherche Scientifique (FNRS), Laboratoire de Psychologie Médicale, Université Libre de Bruxelles, Belgium. mnoro@ulb.ac.be
Antonijevic
Irina
I
Forray
Carlos
C
Kasper
Siegfried
S
Kocabas
Neslihan Aygun
NA
Lecrubier
Yves
Y
Linotte
Sylvie
S
Mendlewicz
Julien
J
Montgomery
Stuart
S
Snyder
Lenore
L
Souery
Daniel
D
Verbanck
Paul
P
Zohar
Joseph
J
Massat
Isabelle
I
D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D004351:Drug Resistance; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome
D000928:Antidepressive Agents; D044402:Receptor, Serotonin, 5-HT2A; D044282:Receptor, Serotonin, 5-HT1A