title: The informatics core of the Alzheimer's Disease Neuroimaging Initiative.
abstract: The Alzheimer's Diseases Neuroimaging Initiative project has brought together geographically distributed investigators, each collecting data on the progression of Alzheimer's disease. The quantity and diversity of the imaging, clinical, cognitive, biochemical, and genetic data acquired and generated throughout the study necessitated sophisticated informatics systems to organize, manage, and disseminate data and results. We describe, here, a successful and comprehensive system that provides powerful mechanisms for processing, integrating, and disseminating these data not only to support the research needs of the investigators who make up the Alzheimer's Diseases Neuroimaging Initiative cores, but also to provide widespread data access to the greater scientific community for the study of Alzheimer's Disease.
authors.affiliation: Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA. toga@loni.ucla.edu
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: Karen L
authors.initials: KL
authors.lastname: Crawford
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D003195:Computer Communication Networks; D003952:Diagnostic Imaging; D018450:Disease Progression; D006801:Humans; D048088:Informatics; D016247:Information Storage and Retrieval
references.citation: Am J Bioeth. 2006 Mar-Apr;6(2):W24-31
references.pmid: 16500831
references.citation: Neuroinformatics. 2008 Summer;6(2):135-48
references.pmid: 18512163
references.citation: Hum Brain Mapp. 2007 Sep;28(9):892-903
references.pmid: 17295313
references.citation: J Magn Reson Imaging. 2008 Apr;27(4):685-91
references.pmid: 18302232
references.citation: Neuroimage. 2008 Jan 15;39(2):693-706
references.pmid: 17964812
references.citation: Neuroinformatics. 2007 Spring;5(1):3-10
references.pmid: 17426350
references.citation: Nat Neurosci. 2001 Dec;4(12):1253-8
references.pmid: 11694885
references.citation: Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322
references.pmid: 11545704
references.citation: Neuroimage. 2009 May 15;46(1):154-9
references.pmid: 19457369
references.citation: Annu Rev Neurosci. 2005;28:1-23
references.pmid: 15651931
references.citation: Hum Brain Mapp. 2009 Feb;30(2):347-54
references.pmid: 19067328
references.citation: Brain Cogn. 2002 Dec;50(3):345-57
references.pmid: 12480482
references.citation: J Am Med Inform Assoc. 2001 Sep-Oct;8(5):401-30
references.pmid: 11522763
references.citation: Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1323-39
references.pmid: 11545705
references.citation: Soc Stud Sci. 2001 Oct;31(5):635-80
references.pmid: 11811207
references.citation: Science. 2004 Mar 19;303(5665):1777-8
references.pmid: 15031482
references.citation: Neuroimage. 2008 Aug 1;42(1):178-95
references.pmid: 18519166
references.citation: Neuroimage. 2006 Aug 1;32(1):79-92
references.pmid: 16697666
references.citation: Nat Rev Neurosci. 2002 Apr;3(4):311-3
references.pmid: 11967561
references.citation: Lancet Neurol. 2007 Jun;6(6):480-1
references.pmid: 17509479