title: Study of cross-reactivity between proton pump inhibitors.
abstract: Several studies have demonstrated different cross-reactivity patterns between proton pump inhibitors (PPIs). The aim of this study was to investigate cross-reactivity between commercially available PPIs and establish a procedure for performing cutaneous tests for verifying PPI allergy. We performed skin prick and intradermal tests with all commercially available PPIs in 5 patients with clinical allergy to omeprazole and observed positive results in all patients. We report 5 cases of immunoglobulin (Ig) E-mediated allergy to omeprazole and document cross-reactivity by skin testing between all the PPIs studied. We also found that the probability of confirming an IgE-mediated mechanism with skin tests decreases with time. Finally, we propose a hypothesis that could explain the different PPI cross-reactivity patterns reported.
authors.affiliation: Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain. materesas@hotmail.com
authors.forename: M T
authors.initials: MT
authors.lastname: Sobrevia Elfau
authors.forename: M
authors.initials: M
authors.lastname: Garcés Sotillos
authors.forename: L
authors.initials: L
authors.lastname: Ferrer Clavería
authors.forename: N
authors.initials: N
authors.lastname: Segura Arazuri
authors.forename: S
authors.initials: S
authors.lastname: Monzón Ballarin
authors.forename: C
authors.initials: C
authors.lastname: Colás Sanz
mesh_terms: D000328:Adult; D000799:Angioedema; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D009853:Omeprazole / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D012882:Skin Tests; D014581:Urticaria
chemical_list: D054328:Proton Pump Inhibitors; D009853:Omeprazole