title: Reactive nonsexually related acute genital ulcers: review of cases evaluated at Mayo Clinic.
abstract: BACKGROUND
  Reactive nonsexually related acute genital ulcers (RNSRAGU) occur in pubertal girls after an acute systemic infection.
  
  
  OBJECTIVE
  We sought to characterize RNSRAGU by reviewing the medical records of patients with this disorder.
  
  
  METHODS
  We searched our medical index database from 1997 to 2007 for RNSRAGU cases. Questionnaires were mailed to identified patients.
  
  
  RESULTS
  The study included 10 patients; 5 responded to the questionnaire. The mean age at onset was 11.5 years. Vulvar ulcers were preceded by viral gastroenteritis (n = 3), viral upper respiratory tract infection (n = 3), streptococcal pharyngitis (n = 1), influenza (n = 1), and other nonspecific febrile illnesses (n = 2). Seven patients had oral involvement also; 6 had at least one recurrence; and 3 were hospitalized for pain control. Analgesics and topical corticosteroids were the most common treatments. Ulcerations resolved within several weeks in all patients.
  
  
  CONCLUSIONS
  Retrospective study design, small study size, and 50% questionnaire response rate are limitations.
  
  
  CONCLUSIONS
  Although rare, RNSRAGU should be considered when genital ulceration follows an acute systemic illness.
authors.affiliation: Division of Clinical Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Lehman
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Bruce
authors.forename: David A
authors.initials: DA
authors.lastname: Wetter
authors.forename: Sara B
authors.initials: SB
authors.lastname: Ferguson
authors.forename: Roy S
authors.initials: RS
authors.lastname: Rogers
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000700:Analgesics / Q000008:administration & dosage; D002648:Child; D003218:Condylomata Acuminata / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005759:Gastroenteritis / Q000150:complications; D006801:Humans; D007239:Infections / Q000150:complications*; D007251:Influenza, Human / Q000150:complications; D010612:Pharyngitis / Q000150:complications; D011379:Prognosis; D012141:Respiratory Tract Infections / Q000150:complications; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000150:complications; D011795:Surveys and Questionnaires; D014777:Virus Diseases / Q000150:complications; D014845:Vulvar Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000700:Analgesics