title: Blind source separation of hemodynamics from magnetic resonance perfusion brain images using independent factor analysis.
abstract: Perfusion magnetic resonance brain imaging induces temporal signal changes on brain tissues, manifesting distinct blood-supply patterns for the profound analysis of cerebral hemodynamics. We employed independent factor analysis to blindly separate such dynamic images into different maps, that is, artery, gray matter, white matter, vein and sinus, and choroid plexus, in conjunction with corresponding signal-time curves. The averaged signal-time curve on the segmented arterial area was further used to calculate the relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), and mean transit time (MTT). The averaged ratios for rCBV, rCBF, and MTT between gray and white matters for normal subjects were congruent with those in the literature.
authors.affiliation: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, Pei-Tou, Taipei 112, Taiwan.
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Chou
authors.forename: Chia-Feng
authors.initials: CF
authors.lastname: Lu
authors.forename: Wan-Yuo
authors.initials: WY
authors.lastname: Guo
authors.forename: Yu-Te
authors.initials: YT
authors.lastname: Wu
references.citation: J Cereb Blood Flow Metab. 1999 Jul;19(7):701-35
references.pmid: 10413026
references.citation: J Cereb Blood Flow Metab. 1998 Oct;18(10):1143-56
references.pmid: 9778191
references.citation: J Magn Reson Imaging. 1997 Jan-Feb;7(1):47-55
references.pmid: 9039593
references.citation: Acta Radiol. 1995 Sep;36(5):520-8
references.pmid: 7640098
references.citation: Magn Reson Med. 2007 Jan;57(1):181-91
references.pmid: 17191233
references.citation: Magn Reson Med. 2003 Sep;50(3):614-22
references.pmid: 12939770
references.citation: Magn Reson Med. 1996 Nov;36(5):715-25
references.pmid: 8916022
references.citation: Phys Med Biol. 1984 Sep;29(9):1109-16
references.pmid: 6483975
references.citation: J Nucl Med. 1998 Oct;39(10):1696-702
references.pmid: 9776271
references.citation: J Nucl Med. 1995 Sep;36(9):1714-22
references.pmid: 7658236
references.citation: Magn Reson Med. 2003 Jul;50(1):164-74
references.pmid: 12815691
references.citation: Neuroimage. 2006 Apr 1;30(2):400-16
references.pmid: 16360320
references.citation: J Nucl Med. 2001 May;42(5):782-7
references.pmid: 11337577
references.citation: Magn Reson Med. 1990 May;14(2):249-65
references.pmid: 2345506
references.citation: Neural Comput. 1999 May 15;11(4):803-51
references.pmid: 10226184
references.citation: Radiology. 1998 Sep;208(3):663-9
references.pmid: 9722843
references.citation: Radiology. 1999 Feb;210(2):519-27
references.pmid: 10207439
references.citation: Magn Reson Med. 1996 Nov;36(5):726-36
references.pmid: 8916023
references.citation: Radiology. 1999 Aug;212(2):340-7
references.pmid: 10429688
references.citation: Phys Med Biol. 1980 Mar;25(2):283-92
references.pmid: 7384214
references.citation: Magn Reson Med. 1994 Jun;31(6):601-10
references.pmid: 8057812
references.citation: Magn Reson Imaging. 1996;14(2):157-62
references.pmid: 8847971
references.citation: Med Image Anal. 2001 Mar;5(1):29-39
references.pmid: 11231175
references.citation: Radiology. 1994 Dec;193(3):637-41
references.pmid: 7972800
references.citation: Neural Netw. 1997 Mar;10(2):257-262
references.pmid: 12662524
references.citation: J Nucl Med. 1992 Sep;33(9):1692-5
references.pmid: 1517845
references.citation: Magn Reson Med. 2001 Feb;45(2):261-8
references.pmid: 11180434