Neuropsychiatric symptoms in dementia patients with and without a history of traumatic brain injury.
The authors aim to determine if a history of traumatic brain injury (TBI) assessed before dementia onset is associated with a higher risk of neuropsychiatric symptoms after dementia onset. A population-based incident series of people with dementia were assessed for TBI prior to onset of dementia and for neuropsychiatric symptoms after the onset, using the Neuropsychiatric Inventory. Participants with predementia TBI were more likely to exhibit disinhibition (12.7% versus 5.4%, OR=2.8, p=0.02), but not other neuropsychiatric symptoms. Traumatic brain injury may increase the risk of disinhibition in patients with dementia.
Rao
Vani
V
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21224, USA. vrao@jhmi.edu
Rosenberg
Paul
P
Miles
Quincy Samus
QS
Patadia
Deepa
D
Treiber
Kate
K
Bertrand
Melaine
M
Norton
Maria
M
Steinberg
Martin
M
Tschanz
JoAnn
J
Lyketsos
Constantine
C
D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001930:Brain Injuries / Q000453:epidemiology* / Q000235:genetics; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000453:epidemiology / Q000235:genetics; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000235:genetics; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology
D053327:Apolipoprotein E4
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