title: Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI.
abstract: Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.
authors.affiliation: Delft University of Technology, Department of Biotechnology, Biocatalysis and Organic Chemistry, Julianalaan 136, 2628 BL Delft, The Netherlands.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Schühle
authors.forename: Patrick
authors.initials: P
authors.lastname: van Rijn
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Luce
authors.initials: L
authors.lastname: Vander Elst
authors.forename: Robert N
authors.initials: RN
authors.lastname: Muller
authors.forename: Marc C A
authors.initials: MC
authors.lastname: Stuart
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schatz
authors.forename: Joop A
authors.initials: JA
authors.lastname: Peters
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D004058:Diffusion; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D009942:Organometallic Compounds / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D006571:Heterocyclic Compounds; D008081:Liposomes; D009942:Organometallic Compounds; D014867:Water; D047250:Calixarenes; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate