title: Can proton pump inhibitors accentuate skin aging?
abstract: Skin aging has long been important to human beings and in recent years this field has received tremendous attention by both researchers and the general population. Cutaneous aging includes two distinct phenomena, intrinsic aging and photoaging, and is characterized mainly by the loss of collagen fibers from dermis. Proton pump inhibitors (PPIs) are widely prescribed gastric acid-reducing agents that are usually consumed for long periods in some conditions such as gastroesophageal reflux disease. We suggest that PPIs can accentuate skin aging by two mechanisms. First, through increasing intralysosomal PH, PPIs can suppress transforming growth factor-beta (TGFbeta) processing and consequently decrease its secretion. Second, through inhibiting MNK, a P-type ATPase with steady-state localization at the trans-Golgi network, PPIs can hamper copper transport and consequently curb lysyl oxidase activity.
authors.affiliation: Dermatology, Medicinal and Natural Products Chemistry Research Center and Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Namazi
authors.forename: Farideh
authors.initials: F
authors.lastname: Jowkar
mesh_terms: D003094:Collagen / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D054328:Proton Pump Inhibitors / Q000494:pharmacology*; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D054328:Proton Pump Inhibitors; D016212:Transforming Growth Factor beta; D003300:Copper; D003094:Collagen