Biospecimen repositories: are blood donors willing to participate?
BACKGROUND
Sponsored by the National Heart, Lung, and Blood Institute, the Retrovirus Epidemiology Donor Studies (REDS-I/-II) have conducted epidemiologic, laboratory, and survey research on volunteer blood donors. Some studies request additional permission to store biospecimens for future studies. The representativeness and applicability of studies performed using repositories may be reduced by low participation rates.


METHODS
Demographics from subjects consenting to participate in the 2007 REDS-II Leukocyte Antibodies Prevalence Study (LAPS) repository were compared to "study-only" subjects. Data from the 1998 REDS-I survey of donor opinion regarding storage and use of biospecimens were also explored.


RESULTS
Overall, 91% of LAPS subjects agreed to participate in the repository. Odds of repository participation were lower among African American and Hispanic donors, 35- to 44-year-olds, donors who had not completed high school, and donors from one geographic location, regardless of other variables. Survey data from 1998 revealed that 97% of respondents approved of long-term storage of biospecimens, although only 87% indicated that they would personally participate. Many respondents would require notification or their permission be obtained before participation. Minority respondents would require permission or notification more often and were less certain they would personally participate in a repository.


CONCLUSIONS
Blood donors are quite willing to participate in biospecimen repositories. Regional differences and lower odds of participation in the minority blood donor population may result in a reduced number of biospecimens available for study and a decreased ability to definitely answer specific research questions in these populations.
Scott
Erik A
EA
BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA. erik.scott@bcw.edu
Schlumpf
Karen S
KS
Mathew
Sunitha M
SM
Mast
Alan E
AE
Busch
Michael P
MP
Gottschall
Jerome L
JL
D000328:Adult; D001741:Black or African American; D000368:Aged; D044466:Asian People; D001782:Blood Donors / Q000523:psychology* / Q000706:statistics & numerical data; D001793:Blood Preservation / Q000523:psychology* / Q000706:statistics & numerical data; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D044465:White People; D055815:Young Adult
Transfusion. 2010 Sep;50(9):1951-8
20561291
Transfusion. 2009 Sep;49(9):1825-35
19453983
Transfusion. 2001 Jun;41(6):736-43
11399812
Nature. 1995 Jan 19;373(6511):178
7816116
Transfusion. 2001 Jul;41(7):878-84
11452155
Transfusion. 2001 Nov;41(11):1341-50
11724976
Transfusion. 2002 Feb;42(2):216-25
11896338
Ann Epidemiol. 2002 May;12(4):248-56
11988413
Vox Sang. 2008 Apr;94(3):242-260
18225990
Transfusion. 2007 Jul;47(7):1197-205
17581154
Transfusion. 2007 Jul;47(7):1110-4
17581143
J Infect Dis. 2009 Jun 1;199(11):1592-8
19385734
Transfusion. 2003 Feb;43(2):165-72
12559011
Transfusion. 2005 Jul;45(7):1073-83
15987350
J Infect Dis. 2009 Jun 1;199(11):1564-6
19385737
Transfusion. 2007 Jul;47(7):1162-71
17581150
Transfusion. 2007 Apr;47(4):563-4
17381611
Transfusion. 2007 Jul;47(7):1172-9
17581151
Transfusion. 2002 Oct;42(10):1279-84
12423511
Transfusion. 2004 May;44(5):667-74
15104646
N C Med J. 2004 Nov-Dec;65(6):385-7
15714732
PLoS Med. 2006 Feb;3(2):e19
16318411
Transfusion. 2003 Jan;43(1):7-16
12519425
Transfusion. 2009 Mar;49(3):519-23
19040492
JAMA. 2004 Jun 9;291(22):2720-6
15187053