Joining the dots: from chromatin remodeling to neuronal plasticity.
In recent years spectacular advances in the field of epigenetics have taken place. Multiple lines of evidence that connect epigenetic regulation to brain functions have been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. Control is achieved through several covalent modifications that occur both on DNA and chromatin. Specific modifications mediate many developmental processes and adult brain functions, such as synaptic plasticity and memory. In this review, we focus on crucial chromatin remodeling events that mediate long-lasting neuronal responses. The challenging goal is to reach sufficient understanding of these epigenetic pathways in the brain so that they may be useful for future development of specific pharmacological strategies.
Zocchi
Loredana
L
Department of Pharmacology, School of Medicine, University of California-Irvine, Irvine CA 92697, USA.
Sassone-Corsi
Paolo
P
D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
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