title: Post-transcriptional global regulation by CsrA in bacteria.
abstract: Global regulation allows bacteria to rapidly modulate the expression of a large variety of unrelated genes in response to environmental changes. Global regulators act at different levels of gene expression. This review focuses on CsrA, a post-transcriptional regulator that affects translation of its gene targets by binding mRNAs. CsrA controls a large variety of physiological processes such as central carbon metabolism, motility and biofilm formation. The activity of CsrA is itself tightly regulated by the CsrB and CsrC small RNAs and the BarA-UvrY two-component system.
authors.affiliation: Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041, Gosselies, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Timmermans
authors.forename: Laurence
authors.initials: L
authors.lastname: Van Melderen
mesh_terms: D000595:Amino Acid Sequence; D018441:Biofilms; D002244:Carbon / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D010770:Phosphotransferases / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D012342:RNA, Small Nuclear / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C093587:CsrA protein, E coli; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; D012342:RNA, Small Nuclear; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C419603:UvrY protein, E coli; C074276:barA protein, E coli; D002244:Carbon; D010770:Phosphotransferases
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