Acute Chagas' disease in postrenal transplant and treatment with benzonidazole.
Transplanted organs may act as a route of transmission of infectious diseases, such as Chagas' disease. The aim of this study was to describe the transmission of the Trypanosoma cruzi through a renal transplant and the anatomo-clinical evolution of the patient after treatment with benzonidazole. The patient was a 31-year-old white male from the State of Minas Gerais in Brazil. He had renal failure secondary to diabetes and later received a kidney from a cadaveric donor. The patient was undergoing immunosuppression therapy with azathioprine, cyclosporine A, and prednisone. After the transplant, he developed an acute phase of Chagas' disease and complications from diabetes and died 2 months later. In the autopsy, T cruzi amastigotes were found in the transplanted kidney, heart, bladder, liver, and pancreas. An important reduction in the parasitemia was obtained through the treatment of the infection with benzonidazole; however, the patient died due to complications from diabetes associated with tissue lesions caused by T cruzi.
Silva
Alex Eduardo
AE
Discipline of General Pathology, Triângulo Mineiro Federal University, Uberaba, the State of Minas Gerais, Brazil.
Silva
Anna Carolina Fabiana Lúcia
AC
Faleiros
Ana Carolina Guimarães
AC
Guimarães
Camila Souza de Oliveira
CS
Corrêa
Rosana Rosa Miranda
RR
Oliveira
Flávia Aparecida
FA
Correia
Dalmo
D
Teixeira
Alan César
AC
Ramirez
Luís Eduardo
LE
Teixeira
Vicente de Paula Antunes
Vde P
dos Reis
Marlene Antônia
MA
D000208:Acute Disease; D000328:Adult; D014355:Chagas Disease / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011183:Postoperative Complications; D051437:Renal Insufficiency / Q000601:surgery; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology
D007166:Immunosuppressive Agents; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole