[Late gadolinium enhancement in the diagnostics of ischemic heart disease: technical principles, contrast optimization and clinical application].
BACKGROUND
The purpose of the study was to explore a "dark blood" technique and to compare it with a standard inversion recovery gradient echo (IR GRE) sequence in the visualization of myocardial infarction.


METHODS
A total of 9 patients were examined with standard IR GRE and a "dark blood" sequence 15 mins after contrast medium application (0.2 mmol/kg body weight gadobenate dimeglumine). Contrast-to-noise ratios (CNR) were calculated for each sequence.


RESULTS
The CNR(inf-lvc) was significantly higher in the "dark blood" technique compared to the IR GRE sequence, while the CNR(inf-myo) was significantly lower.


CONCLUSIONS
Small subendocardial infarctions may be easier to detect with the "dark blood" technique. However, the standard IR GRE sequence is superior in the demarcation of infarctions in relation to the myocardium and cannot be replaced by the "dark blood" technique.
Bauner
K U
KU
Institut für Klinische Radiologie, Klinikum der Ludwig-Maximilians-Universität München, Campus Grosshadern, Marchioninistr. 15, 81377, München, Deutschland. Kerstin.Bauner@med.uni-muenchen.de
Biffar
A
A
Greif
M
M
Becker
A
A
Picciolo
M
M
Theisen
D
D
Sandner
T A
TA
Notohamiprodjo
M
M
Reiser
M F
MF
Wintersperger
B J
BJ
D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
Lancet. 2003 Feb 1;361(9355):374-9
12573373
AJR Am J Roentgenol. 2006 Mar;186(3):627-33
16498088
Circulation. 2006 Jul 4;114(1):32-9
16801462
Radiology. 2005 Dec;237(3):854-60
16304107
N Engl J Med. 2000 Nov 16;343(20):1445-53
11078769
Circulation. 2006 Jun 13;113(23):2733-43
16754804
Circulation. 2002 Jan 15;105(2):224-9
11790705
Invest Radiol. 2009 Feb;44(2):95-104
19077911
Magn Reson Med. 2007 Jul;58(1):34-40
17659622
Radiology. 2005 Sep;236(3):1041-6
16055693
Radiology. 2001 Jan;218(1):215-23
11152805
Circulation. 2007 Apr 17;115(15):2006-14
17389270
Circulation. 2009 Nov 24;120(21):2069-76
19901193
Invest Radiol. 2006 Feb;41(2):148-53
16428986
Magn Reson Med. 2002 Feb;47(2):372-83
11810682
Eur Heart J. 2004 Nov;25(21):1940-65
15522474
Circulation. 1998 Mar 3;97(8):765-72
9498540
Circulation. 2003 Oct 21;108(16):1945-53
14557364
J Cardiovasc Magn Reson. 2007;9(2):93-491
17192234
Invest Radiol. 2007 Jun;42(6):361-71
17507806
Circulation. 1999 Nov 9;100(19):1992-2002
10556226
Circulation. 2006 Feb 21;113(7):969-76
16476852
Radiology. 2004 Dec;233(3):921-6
15516607
JACC Cardiovasc Imaging. 2009 Jan;2(1):34-44
19356530
Radiology. 2004 Mar;230(3):845-51
14990846
Circulation. 1996 Dec 15;94(12):3318-26
8989146
Invest Radiol. 1978 Mar-Apr;13(2):103-9
77854
Can J Cardiol. 1990 Dec;6(10):439-44
2148709
J Magn Reson Imaging. 2008 Jan;27(1):229-38
18050331
Magn Reson Med. 2007 Aug;58(2):365-72
17654582
Magn Reson Imaging. 1993;11(2):207-18
8455431