title: Neural modulation by binocular disparity greatest in human dorsal visual stream.
abstract: Although cortical activation to binocular disparity can be demonstrated throughout occipital and parietal cortices, the relative contributions to depth perception made by different human cortical areas have not been established. To investigate whether different regions are optimized for specific disparity ranges, we have measured the responses of occipital and parietal areas to different magnitudes of binocular disparity. Using stimuli consisting of sinusoidal depth modulations, we measured cortical activation when the stimuli were located at pedestal disparities of 0, 0.1, 0.35, and 0.7 degrees from fixation. Across all areas, occipital and parietal, there was an increase in BOLD signal with increasing pedestal disparity, compared with a plane at zero disparity. However, the greatest modulation of response by the different pedestals was found in the dorsal visual areas and the parietal areas. These differences contrast with the response to the zero disparity plane, compared with fixation, which is greatest in the early visual areas, smaller in the ventral and dorsal visual areas, and absent in parietal areas. Using the simultaneously acquired psychophysical data we also measured a greater response to correct than to incorrect trials, an effect that increased with rising pedestal disparity and was greatest in dorsal visual and parietal areas. These results illustrate that the dorsal stream, along both its occipital and parietal branches, can reliably discriminate a large range of disparities.
authors.affiliation: Department of Physiology, Anatomy and Genetics, John Radcliffe Hospital, University of Oxford, Oxford, UK. lori.minini@dpag.ox.ac.uk
authors.forename: Loredana
authors.initials: L
authors.lastname: Minini
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Parker
authors.forename: Holly
authors.initials: H
authors.lastname: Bridge
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000502:physiology; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology; D015357:Vision Disparity / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology*
chemical_list: D010100:Oxygen
references.citation: J Vis. 2007 Dec 17;7(14):15.1-14
references.pmid: 18217810
references.citation: J Neurosci. 2006 Jun 21;26(25):6791-802
references.pmid: 16793886
references.citation: Nat Rev Neurosci. 2007 May;8(5):379-91
references.pmid: 17453018
references.citation: J Neurophysiol. 2004 Sep;92(3):1586-96
references.pmid: 15102899
references.citation: Annu Rev Neurosci. 2001;24:203-38
references.pmid: 11283310
references.citation: J Neurophysiol. 2007 Feb;97(2):1553-65
references.pmid: 17151220
references.citation: Med Image Anal. 2001 Jun;5(2):143-56
references.pmid: 11516708
references.citation: J Neurosci. 2004 Sep 15;24(37):8170-80
references.pmid: 15371518
references.citation: Neuroimage. 2001 Dec;14(6):1370-86
references.pmid: 11707093
references.citation: J Neurophysiol. 2005 Aug;94(2):1372-84
references.pmid: 15817644
references.citation: J Neurophysiol. 2002 Jan;87(1):209-21
references.pmid: 11784743
references.citation: J Neurosci. 2006 May 10;26(19):5098-108
references.pmid: 16687501
references.citation: J Neurosci. 2009 Jan 21;29(3):727-42
references.pmid: 19158299
references.citation: J Neurophysiol. 2004 Sep;92(3):1880-91
references.pmid: 15331652
references.citation: J Neurosci. 2008 Oct 29;28(44):11315-27
references.pmid: 18971473
references.citation: J Neurosci. 1988 Dec;8(12):4531-50
references.pmid: 3199191
references.citation: Vision Res. 1984;24(6):533-42
references.pmid: 6740973
references.citation: J Neurophysiol. 1977 Nov;40(6):1392-405
references.pmid: 411898
references.citation: Neuron. 2003 Feb 20;37(4):693-701
references.pmid: 12597865
references.citation: J Neurophysiol. 2005 Apr;93(4):1823-6
references.pmid: 15774707
references.citation: J Neurosci. 2001 Jul 1;21(13):4809-21
references.pmid: 11425908
references.citation: J Neurophysiol. 2007 Jul;98(1):241-52
references.pmid: 17507498
references.citation: Neuropsychologia. 2006;44(13):2647-67
references.pmid: 16343560
references.citation: Neuron. 2003 Jul 31;39(3):555-68
references.pmid: 12895427
references.citation: Science. 2001 Nov 9;294(5545):1350-4
references.pmid: 11701930
references.citation: J Neurophysiol. 2001 Oct;86(4):2054-68
references.pmid: 11600661
references.citation: Annu Rev Neurosci. 2004;27:649-77
references.pmid: 15217346
references.citation: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8217-22
references.pmid: 10393975
references.citation: Nat Neurosci. 2005 Apr;8(4):505-11
references.pmid: 15778711
references.citation: Neuroimage. 1995 Jun;2(2):89-101
references.pmid: 9343592
references.citation: J Neurosci. 2000 Jun 15;20(12):4758-67
references.pmid: 10844045
references.citation: Nature. 1997 Sep 18;389(6648):280-3
references.pmid: 9305841
references.citation: Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322
references.pmid: 11545704
references.citation: J Neurosci. 1999 Jul 1;19(13):5602-18
references.pmid: 10377367
references.citation: J Neurophysiol. 2005 Aug;94(2):1358-71
references.pmid: 15817643
references.citation: Nature. 1998 Apr 16;392(6677):714-7
references.pmid: 9565031
references.citation: Neuron. 2004 Apr 22;42(2):297-310
references.pmid: 15091344