Difference between random and imprinted X inactivation in common voles.
During early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the future inactive X-chromosome is random. We mapped several genes on the X-chromosomes of five common vole species and compared their expression and methylation patterns in somatic and extraembryonic tissues, where random and imprinted X-inactivation occurs, respectively. In extraembryonic tissues, more genes were expressed on the inactive X-chromosome than in somatic tissues. We also found that the methylation status of the X-linked genes was always in accordance with their expression pattern in somatic, but not in extraembryonic tissues. The data provide new evidence that imprinted X-inactivation is less complete and/or stable than the random form and DNA methylation contributes less to its maintenance.
Dementyeva
Elena V
EV
Russian Academy of Sciences, Siberian Department, Institute of Cytology and Genetics, ac. Lavrentyev Avenue 10, Novosibirsk, Russia.
Shevchenko
Alexander I
AI
Anopriyenko
Olga V
OV
Mazurok
Nina A
NA
Elisaphenko
Eugeny A
EA
Nesterova
Tatyana B
TB
Brockdorff
Neil
N
Zakian
Suren M
SM
D000818:Animals; D003411:Arvicolinae / Q000235:genetics*; D002874:Chromosome Mapping; D019175:DNA Methylation; D005260:Female; D015870:Gene Expression; D050172:Genes, X-Linked; D018392:Genomic Imprinting; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009115:Muridae; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics; D012097:Repressor Proteins; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism; D049951:X Chromosome Inactivation
D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012097:Repressor Proteins; C077885:XIST non-coding RNA
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