Low molecular weight MPEG-assisted organic synthesis.
A toolkit of low molecular weight MPEG-supported coupling agents ((M)IIDQ, (M)EDCI), reagents for the Mitsunobu reaction ((M)DEAD, (M)TPP), an alternative to diazomethane, and scavengers can be used in the solution-phase synthesis of amides, esters and ureas and are easily removed after use by solid-phase extraction (MSPE) using normal silica.
Figlus
Marek
M
WestCHEM Department of Chemistry, University of Glasgow, Glasgow, UK G12 8QQ.
Tarruella
Albert C
AC
Messer
Anastasia
A
Sollis
Steven L
SL
Hartley
Richard C
RC
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D003978:Diazomethane / Q000737:chemistry; D004952:Esters; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D014508:Urea / Q000138:chemical synthesis / Q000737:chemistry
D000577:Amides; D004952:Esters; D011092:Polyethylene Glycols; D003978:Diazomethane; D012822:Silicon Dioxide; D014508:Urea; C028210:monomethoxypolyethylene glycol