title: Bone status in adolescents with type 1 diabetes.
abstract: OBJECTIVE
  The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and growth variables was analysed.
  
  
  METHODS
  Group I consisted of 99 pubertal (Tanner > or = 2) adolescents (49 female), aged 14.3 +/- 2.5 years, diabetes duration 4.6 +/- 2.3 years. Controls (group II) were 297 children, matched by sex and age, from a healthy population. The influence of glycated haemoglobin (current: HbA(1c)D; last year's mean: HbA(1c)Y; whole duration mean: HbA(1c)T), diabetes duration, percentage of life with disease and daily insulin requirement (DIR) on amplitude dependent speed of sound (Ad-SoS) at distal phalanges was studied.
  
  
  RESULTS
  In comparison to the control group, adolescents with type 1 diabetes presented significantly higher BMI SDS (0.82 [95% CI 0.54, 1.10] vs -0.06 [95% CI -0.16, 0.04] p < 0.001) and lower Ad-SoS SDS (-0.34 [95% CI -0.57, -0.11] vs -0.03 [95% CI -0.15, 0.08], p < 0.05). No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA(1c)T was higher than 7.0% when compared with those whose HbA(1c)T was lower.
  
  
  CONCLUSIONS
  Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.
authors.affiliation: Department of Paediatrics, Clinical Hospital No. 1, 3-go Maja 13-15, 41-800 Zabrze, Poland. pjarosz-chobot@sum.edu.pl
authors.forename: A P
authors.initials: AP
authors.lastname: Chobot
authors.forename: A
authors.initials: A
authors.lastname: Haffke
authors.forename: J
authors.initials: J
authors.lastname: Polanska
authors.forename: Z P
authors.initials: ZP
authors.lastname: Halaba
authors.forename: G
authors.initials: G
authors.lastname: Deja
authors.forename: P
authors.initials: P
authors.lastname: Jarosz-Chobot
authors.forename: W
authors.initials: W
authors.lastname: Pluskiewicz
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D002648:Child; D002851:Chromatography, High Pressure Liquid; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D018579:Patient Selection; D011627:Puberty / Q000378:metabolism*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
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