title: p63 in skin development and ectodermal dysplasias.
abstract: The transcription factor p63 is critically important for skin development and maintenance. Processes that require p63 include epidermal lineage commitment, epidermal differentiation, cell adhesion, and basement membrane formation. Not surprisingly, alterations in the p63 pathway underlie a subset of ectodermal dysplasias, developmental syndromes in which the skin and skin appendages do not develop normally. This review summarizes the current understanding of the role of p63 in normal development and ectodermal dysplasias.
authors.affiliation: Department of Dermatology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA. Maranke.Koster@ucdenver.edu
authors.forename: Maranke I
authors.initials: MI
authors.lastname: Koster
mesh_terms: D004475:Ectoderm / Q000002:abnormalities* / Q000254:growth & development*; D004476:Ectodermal Dysplasia / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*
chemical_list: C081876:CKAP4 protein, human; D008565:Membrane Proteins
references.citation: Cell Cycle. 2009 Apr 15;8(8):1185-95
references.pmid: 19282665
references.citation: Am J Med Genet A. 2009 Sep;149A(9):1900-6
references.pmid: 19681128
references.citation: Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3255-60
references.pmid: 17360634
references.citation: Oncogene. 1999 Jan 14;18(2):397-406
references.pmid: 9927196
references.citation: Cell. 2005 Mar 25;120(6):843-56
references.pmid: 15797384
references.citation: Hum Mol Genet. 2008 Jul 1;17(13):1968-77
references.pmid: 18364388
references.citation: Curr Opin Cell Biol. 2006 Oct;18(5):463-71
references.pmid: 16919434
references.citation: J Biol Chem. 2008 Dec 5;283(49):34241-9
references.pmid: 18849344
references.citation: Stem Cells. 2008 Feb;26(2):440-4
references.pmid: 18032703
references.citation: Cell Stem Cell. 2009 Jun 5;4(6):499-502
references.pmid: 19497277
references.citation: J Biol Chem. 2004 Nov 26;279(48):50069-77
references.pmid: 15361520
references.citation: Cell Stem Cell. 2009 Jul 2;5(1):64-75
references.pmid: 19570515
references.citation: Cell Cycle. 2005 Nov;4(11):1625-31
references.pmid: 16258268
references.citation: Carcinogenesis. 2006 Jan;27(1):53-63
references.pmid: 16081516
references.citation: Int J Biol Sci. 2009;5(3):276-85
references.pmid: 19343113
references.citation: Am J Hum Genet. 2001 Sep;69(3):481-92
references.pmid: 11462173
references.citation: Genes Dev. 2006 Nov 15;20(22):3185-97
references.pmid: 17114587
references.citation: Genes Dev. 2004 Jan 15;18(2):126-31
references.pmid: 14729569
references.citation: Cell Cycle. 2007 Feb 1;6(3):262-8
references.pmid: 17224651
references.citation: Am J Med Genet A. 2009 Sep;149A(9):1952-7
references.pmid: 19353588
references.citation: J Biol Chem. 2008 Jul 18;283(29):20198-208
references.pmid: 18492670
references.citation: Nature. 1999 Apr 22;398(6729):708-13
references.pmid: 10227293
references.citation: J Med Genet. 2002 Jun;39(6):377-81
references.pmid: 12070241
references.citation: Nature. 2003 Mar 20;422(6929):317-22
references.pmid: 12646922
references.citation: Development. 2007 Jan;134(1):13-8
references.pmid: 17164413
references.citation: J Cell Sci. 1994 Feb;107 ( Pt 2):693-700
references.pmid: 8207091
references.citation: Development. 2008 Feb;135(4):743-53
references.pmid: 18199584
references.citation: Genesis. 2002 Jun;33(2):97-101
references.pmid: 12112878
references.citation: Cell Cycle. 2009 Nov 1;8(21):3545-51
references.pmid: 19829080
references.citation: Cell. 1977 Jun;11(2):417-22
references.pmid: 890737
references.citation: EMBO J. 2009 Jul 8;28(13):1904-15
references.pmid: 19494829
references.citation: PLoS One. 2008;3(10):e3441
references.pmid: 18927616
references.citation: Cell. 2007 May 4;129(3):523-36
references.pmid: 17482546
references.citation: Development. 1994 Sep;120(9):2369-83
references.pmid: 7525178
references.citation: Cancer Res. 2009 Nov 15;69(22):8563-71
references.pmid: 19861536
references.citation: Nature. 2008 Mar 13;452(7184):225-9
references.pmid: 18311128
references.citation: Cell Cycle. 2006 Jan;5(2):205-12
references.pmid: 16410722
references.citation: Mol Cell Biol. 2003 Apr;23(7):2264-76
references.pmid: 12640112
references.citation: Am J Hum Genet. 2000 Jul;67(1):59-66
references.pmid: 10839977
references.citation: Exp Dermatol. 2009 Dec;18(12):1016-21
references.pmid: 19555433
references.citation: Hum Mol Genet. 1998 Mar;7(3):563-9
references.pmid: 9467018
references.citation: Nature. 1999 Apr 22;398(6729):714-8
references.pmid: 10227294
references.citation: J Dermatol. 2004 Mar;31(3):171-87
references.pmid: 15187337
references.citation: PLoS One. 2009 May 20;4(5):e5623
references.pmid: 19461998
references.citation: J Invest Dermatol. 2009 Jan;129(1):60-9
references.pmid: 18633439
references.citation: Nat Med. 2005 Dec;11(12):1351-4
references.pmid: 16288281
references.citation: J Cell Sci. 1998 Oct;111 ( Pt 19):2867-75
references.pmid: 9730979
references.citation: Genes Dev. 2002 May 1;16(9):1089-101
references.pmid: 12000792
references.citation: Cancer Res. 2000 Aug 1;60(15):4016-20
references.pmid: 10945600
references.citation: Cell. 1999 Oct 15;99(2):143-53
references.pmid: 10535733
references.citation: PLoS One. 2008 Jul 23;3(7):e2715
references.pmid: 18648642
references.citation: Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R51-60
references.pmid: 12668597
references.citation: Cell Cycle. 2006 Apr;5(7):750-8
references.pmid: 16582625
references.citation: Cell Death Differ. 2008 Jul;15(7):1187-95
references.pmid: 18483491
references.citation: Development. 2008 Apr;135(7):1377-88
references.pmid: 18326838
references.citation: Differentiation. 1981;20(3):203-16
references.pmid: 7040148
references.citation: PLoS One. 2007 Jul 11;2(7):e610
references.pmid: 17622355
references.citation: Nat Cell Biol. 2006 Jun;8(6):551-61
references.pmid: 16715076
references.citation: Am J Med Genet A. 2009 Sep;149A(9):1894-9
references.pmid: 19676057
references.citation: Annu Rev Cell Dev Biol. 2007;23:93-113
references.pmid: 17489688
references.citation: Hum Mol Genet. 1994 Aug;3(8):1345-54
references.pmid: 7987313
references.citation: Genes Dev. 2006 Apr 15;20(8):1028-42
references.pmid: 16618808
references.citation: Nat Genet. 2003 Jun;34(2):209-14
references.pmid: 12766770
references.citation: Arch Dermatol. 2005 Dec;141(12):1567-73
references.pmid: 16365259
references.citation: Nat Cell Biol. 2004 Nov;6(11):1082-93
references.pmid: 15517002
references.citation: Am J Med Genet A. 2009 Sep;149A(9):1942-7
references.pmid: 19681108
references.citation: Mol Cell. 1998 Sep;2(3):305-16
references.pmid: 9774969
references.citation: Nat Genet. 2003 Jun;34(2):203-8
references.pmid: 12766769
references.citation: Nucleic Acids Res. 2006 Feb 09;34(3):928-38
references.pmid: 16473849
references.citation: Nucleic Acids Res. 2009 Oct;37(18):6092-104
references.pmid: 19700772
references.citation: J Biol Chem. 2009 Oct 30;284(44):30574-82
references.pmid: 19717565
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14677-82
references.pmid: 16203973
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12753-8
references.pmid: 16908849
references.citation: Am J Med Genet A. 2009 Sep;149A(9):1916-21
references.pmid: 19676059
references.citation: Hum Mol Genet. 2001 Feb 1;10(3):221-9
references.pmid: 11159940
references.citation: J Med Genet. 2005 Apr;42(4):292-8
references.pmid: 15805154