Carving the clock at its component joints: neural bases for interval timing.
Models of time perception often describe an "internal clock" that involves at least two components: an accumulator and a comparator. We used functional magnetic resonance imaging to test the hypothesis that distinct distributed neural networks mediate these components of time perception. Subjects performed a temporal discrimination task that began with a visual stimulus (S1) that varied parametrically in duration of presentation. A varying interstimulus interval was followed by a second visual stimulus (S2). After the S2 offset, the subject indicated whether S2 was longer or shorter than S1. We reasoned that neural activity that correlated with S1 duration would represent accumulator networks. We also reasoned that neural activity that correlated with the difficulty of comparisons for each paired-judgment would represent comparator networks. Using anatomically defined regions of interest, we found duration of S1 significantly correlated with left inferior frontal, supplementary motor area (SMA) and superior temporal regions. Furthermore, task difficulty correlated with activity within bilateral inferior frontal gyri. Therefore accumulator and comparator functioning of the internal clock are mediated by distinct as well as partially overlapping neural regions.
Wencil
Elaine B
EB
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ewencil@psych.upenn.edu
Coslett
H Branch
HB
Aguirre
Geoffrey K
GK
Chatterjee
Anjan
A
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D003116:Color; D003627:Data Interpretation, Statistical; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology; D013998:Time Perception / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen
Curr Opin Neurobiol. 1996 Dec;6(6):851-7
9000026
Exp Brain Res. 1999 Apr;125(3):271-80
10229018
Brain Res Cogn Brain Res. 2004 Oct;21(2):133-7
15464347
Neuropsychologia. 1998 Dec;36(12):1283-93
9863682
Neuron. 2003 Apr 24;38(2):317-27
12718864
Pharmacol Biochem Behav. 1986 Dec;25(6):1185-9
2880350
J Neurosci. 1998 Feb 1;18(3):1085-95
9437028
Exp Brain Res. 1990;79(3):504-14
2340870
Neuroimage. 1995 Sep;2(3):173-81
9343600
J Cogn Neurosci. 2008 Jun;20(6):1054-62
18211231
Neuroreport. 2005 Sep 8;16(13):1467-71
16110273
Neuroreport. 1997 Mar 24;8(5):1273-6
9175128
Mem Cognit. 1994 Nov;22(6):673-86
7808276
Neuroimage. 2000 Mar;11(3):228-42
10694465
Endeavour. 1997;21(2):82-7
9237431
Neuropsychologia. 1999 Aug;37(9):1061-70
10468369
Neuropsychologia. 2007 Jan 28;45(2):321-31
16934301
Brain Cogn. 2002 Feb;48(1):195-211
11812042
Brain Res Cogn Brain Res. 2004 Oct;21(2):206-15
15464352
Nat Neurosci. 2001 Mar;4(3):317-23
11224550
Ann N Y Acad Sci. 1984;423:528-41
6588813
Trends Cogn Sci. 2003 Nov;7(11):483-8
14585444
Neurosci Lett. 1997 Oct 10;235(1-2):21-4
9389586
Neurosci Biobehav Rev. 2004 Nov;28(7):747-69
15555682
Pharmacol Biochem Behav. 2003 Apr;75(1):9-15
12759108
Science. 2004 Mar 5;303(5663):1506-8
15001776
Behav Neurosci. 1984 Feb;98(1):3-22
6696797
Neuroimage. 2001 Jan;13(1):37-45
11133307
Perception. 1990;19(6):705-43
2130371
Behav Neurosci. 1988 Feb;102(1):54-60
3355658
Rev Neurosci. 1999;10(2):91-116
10658954
Behav Processes. 2006 Feb 28;71(2-3):107-15
16413701
Curr Opin Neurobiol. 2008 Apr;18(2):137-44
18692573
Trends Cogn Sci. 2006 Sep;10(9):401-6
16899395
J Exp Psychol Hum Percept Perform. 2000 Dec;26(6):1770-87
11129373
Curr Opin Neurobiol. 2003 Apr;13(2):250-5
12744981
Brain Res Cogn Brain Res. 2004 Oct;21(2):193-205
15464351
J Neurophysiol. 2000 Feb;83(2):1079-87
10669519
Exp Brain Res. 2000 Feb;130(3):328-37
10706432
Hum Brain Mapp. 2000 Jun;10(2):49-60
10864229
J Cogn Neurosci. 2006 Mar;18(3):376-87
16513003
J Neurosci. 1997 Jul 15;17(14):5528-35
9204934
Curr Opin Neurobiol. 2008 Apr;18(2):145-52
18708142
Psychopharmacology (Berl). 1983;79(1):10-5
6403957
Neuroreport. 2001 Apr 17;12(5):939-42
11303764
Cognition. 1990 Nov;37(1-2):55-81
2269008
Behav Processes. 2006 Feb 28;71(2-3):226-34
16434151
Neuroimage. 1997 Apr;5(3):199-212
9345549
Psychopharmacology (Berl). 2005 Oct;182(2):232-44
16001114
Brain Res Cogn Brain Res. 2004 Oct;21(2):171-82
15464349
Exp Brain Res. 2002 Feb;142(4):475-85
11845243
Brain Res Cogn Brain Res. 1996 Jun;3(3-4):227-42
8806025
Neuroimage. 2003 Aug;19(4):1532-44
12948709
Ann N Y Acad Sci. 2002 Dec;978:302-17
12582062