title: Long-term outcome of renal transplantation in patients with idiopathic membranous glomerulonephritis (MN).
abstract: BACKGROUND
  Little information is available about the long-term outcome of renal transplanted patients with idiopathic membranous nephropathy (MN).
  
  
  METHODS
  The outcomes of 35 first renal transplants performed between 1975 and 2008 in patients with MN were compared with those of 70 controls transplanted in the same period and matched for sex, age and source of donors.
  
  
  RESULTS
  The mean post-transplant follow-up was 117 ± 86 months for MN patients and 123 ± 83 months for controls. At 15 years, patient survival was 96% in patients with MN and 88% in the controls (P = ns), while graft survival rates were respectively 40% and 69% (P = 0.06). MN recurred in 12 patients (34%), namely in 4/8 (50%) patients who received the kidney from related living donors and in 8/27 (29.6%) who received the kidney from a deceased donor. Recurrence led to graft failure in six patients, all deceased donor kidney recipients, within 54 ± 33 months. The other six grafts are functioning 134 ± 73 months after transplantation. Patients with recurrence were more frequently females (42% vs 4.3%, P = 0.02). The recurrence occurred earlier (4.8 ± 3.0 vs 45.6 ± 46.9 months, P = 0.05), and there was a trend to develop a higher proteinuria (7.1 ± 5.5 vs 3.67 ± 2.6 g/24 h, P = 0.1) in grafts eventually lost because of recurrence.
  
  
  CONCLUSIONS
  The long-term patient survival was similar in renal transplant recipients with MN and in controls. The graft survival was lower in MN patients than in controls, although the difference was at borderline significance. Recurrence occurred in one-third of the patients and caused graft loss in half of them.
authors.affiliation: Divisione di Nefrologia & Dialisi, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, Milano Italy. gmoroni@policlinico.mi.it
authors.forename: Gabriella
authors.initials: G
authors.lastname: Moroni
authors.forename: Beniamina
authors.initials: B
authors.lastname: Gallelli
authors.forename: Silvana
authors.initials: S
authors.lastname: Quaglini
authors.forename: Antonio
authors.initials: A
authors.lastname: Leoni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Banfi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Passerini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Montagnino
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Messa
mesh_terms: D000328:Adult; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000503:physiopathology; D012008:Recurrence; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D016896:Treatment Outcome