title: Microdochectomy in the management of pathologic nipple discharge.
abstract: BACKGROUND
  There is a debate in the literature whether a pathologic nipple discharge is a distinct sign of breast carcinoma. Our own results obtained by the use of microdochectomy as a minimally invasive operative procedure in 184 patients with pathologic nipple discharge were analysed. The aim of this retrospective 20-year study was to assess the efficacy of microdochectomy in detecting early stages of intraductal breast carcinoma.
  
  
  METHODS
  The study included data on 184 patients aged 24-77 years (median 46.6) divided into two groups of premenopausal (n = 123) and postmenopausal (n = 61) women. There were 139 patients with unilateral single-duct sanguinolent discharge and 45 patients with other types of nipple discharge. The operative procedure consisted of the discharging duct excision by use of a guide probe, preceded by cytology and ductography studies.
  
  
  RESULTS
  Histopathology of the excised ducts revealed only three carcinomas in premenopausal women and ten carcinomas in postmenopausal women. In a total of 13 carcinomas, there were 4 ductal carcinomas in situ, detected in patients aged 41-72 (median 66) years. Twelve carcinomas were associated with sanguinolent nipple discharge. Papilloma was the most common histology finding (56.5%).
  
  
  CONCLUSIONS
  Results of the study suggested mainly the association of sanguinolent single-duct nipple discharge and papilloma, whereas the rate of malignancies detected (7.0%) was consistent with literature reports. Microdochectomy proved to be a highly efficient operative method free from any impairment of the breast integrity. Conservative treatment with close clinical monitoring of the patient with cytology and ultrasonographic assessment might be possible in selected cases.
authors.affiliation: Department of Surgery, County Hospital Pozega, Pozega, Croatia.
authors.forename: Josip
authors.initials: J
authors.lastname: Fajdić
authors.forename: Nikola
authors.initials: N
authors.lastname: Gotovac
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Glavić
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Hrgović
authors.forename: Walter
authors.initials: W
authors.lastname: Jonat
authors.forename: Christian
authors.initials: C
authors.lastname: Schem
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000601:surgery*; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D018300:Papilloma, Intraductal / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult