Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
OBJECTIVE
To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by electroencephalograms (EEG) evaluated by quantitative measures.


METHODS
Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function.


RESULTS
Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion.


CONCLUSIONS
Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.
Flisberg
A
A
Department of Pediatrics, The Queen Silvia Children's Hospital Sahlgrenska University Hospital-Östra, Göteborg, Sweden. anders.flisberg@vgregion.se
Kjellmer
I
I
Löfhede
J
J
Löfgren
N
N
Rosa-Zurera
M
M
Lindecrantz
K
K
Thordstein
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007262:Infusions, Intravenous; D018608:Ultrasonography, Doppler; D014661:Vasoconstriction / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin