Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis.
Small non-coding RNAs-microRNAs, are potent negative regulators of gene expression. MicroRNAs are involved in multiple biological processes, metabolic regulation, including cell proliferation, differentiation, and programmed cell death. Since the dysregulation of these processes is a hallmark of cancer, microRNAs can be viewed as major contributors to the pathogenesis of cancer, including initiation and progression of cancer. This review focuses on microRNA biogenesis and function, and their role in cancer, metastasis, drug resistance, and tumorigenesis.
Koturbash
Igor
I
Department of Biological Sciences, University of Lethbridge, AB, Canada.
Zemp
Franz J
FJ
Pogribny
Igor
I
Kovalchuk
Olga
O
D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D042822:Genomic Instability; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D009857:Oncogenes
D014408:Biomarkers, Tumor; D035683:MicroRNAs