AIP gene and familial isolated pituitary adenomas.
Familial pituitary adenomas occurr in the classical syndromes of MEN1 and Carney Complex as well as in Familial Isolated Pituitary Adenomas (FIPA), an autosomal dominant disease with incomplete penetrance. In some families and also rarely in sporadic tumours germline mutations of a gene located on chromosome 11q13 known as the aryl hydrocarbon receptor interacting protein have been found. This article discusses the AIP mutations in these groups and the different molecular interactions of AIP that may play a role in pituitary tumour formation.
Ozfirat
Zehra
Z
Department of Endocrinology, William Harvey Research Institute, Bart's and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK.
Korbonits
Márta
M
D000236:Adenoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004147:Dioxins / Q000633:toxicity; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051096:Proto-Oncogene Proteins c-ret / Q000378:metabolism; D051381:Rats
D004147:Dioxins; D051034:Inhibitor of Apoptosis Proteins; D047908:Intracellular Signaling Peptides and Proteins; C103265:aryl hydrocarbon receptor-interacting protein; D000242:Cyclic AMP; D051096:Proto-Oncogene Proteins c-ret; D010727:Phosphoric Diester Hydrolases; D019204:GTP-Binding Proteins