title: Antiphosphatidylethanolamine antibodies might not be an independent risk factor for further miscarriage in patients suffering recurrent pregnancy loss.
abstract: The prevalence of antiphosphatidylethanolamine antibodies (aPEs) is higher in recurrent pregnancy loss patients than that in women with normal pregnancy. We conducted a cohort study to examine the predictive value of aPE for recurrent pregnancy loss and to determine its clinical significance. We examined plasma protein dependent (P+) and independent (P-) aPE IgG and IgM antibodies in 367 women with two or more unexplained consecutive pregnancy losses. We also examined conventional antiphospholipid antibodies (aPL) such as beta2-glycoprotein I-dependent anticardiolipin antibodies (beta2GPI-dependent aCL), lupus anticoagulant with reference to the dilute activated partial thromboplastin time (aPTT) and the diluted Russell's viper venom time (RVVT). Subsequent pregnancy outcome without medication was examined, and patients with and without aPE were compared. Totals of 37 (10.1%), 14 (3.8%), 23 (6.3%), 6 (1.6%), 9 (2.5%), 10 (2.7%) and 50 (13.6%) of the 367 patients were, respectively, positive for P+aPE IgG, P-aPE IgG, P+aPE IgM, P-aPE IgM, beta2GPI-dependent aCL, lupus anticoagulant by RVVT and LA by aPTT. The patients with aPE differed from patients with beta2GPI-dependent aCL or lupus anticoagulant by RVVT. No difference in live birth rate was apparent between positive and negative aPE patients with no medication. The areas under the curves for each ROC curve for the four aPEs were 0.535, 0.612, 0.546 and 0.533, respectively, so there was no significant variation in diagnostic capacity. We did not obtain any evidence that aPE elevation is an independent risk factor to predict further miscarriage in recurrent pregnancy loss patients.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Obayashi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Sugi
authors.forename: Tamao
authors.initials: T
authors.lastname: Kitaori
authors.forename: Kinue
authors.initials: K
authors.lastname: Katano
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugiura-Ogasawara
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016682:Lupus Coagulation Inhibitor / Q000276:immunology; D049488:Phosphatidylethanolamine Binding Protein / Q000276:immunology* / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000276:immunology* / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D011485:Protein Binding; D012307:Risk Factors
chemical_list: D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor; D049488:Phosphatidylethanolamine Binding Protein; D010714:Phosphatidylethanolamines; C483858:phosphatidylethanolamine