title: Assessment of perineural infiltration and spread of oral squamous cell carcinoma: a clinicohistopathologic study.
abstract: BACKGROUND
  As the tumor spreads through the pathway of least resistance, the present study was carried out to evaluate the presence of perineural infiltration and spread of oral squamous cell carcinoma (OSCC) along the perineural spaces in gingivobuccal sulcus tumors infiltrating into the mandible.
  
  
  OBJECTIVE
  (1) To investigate the incidence of perineural invasion of OSCC along the inferior alveolar nerve and (2) to investigate the neurovascular bundle as a potential route of spread of OSCC.
  
  
  METHODS
  Twenty-six patients with histopathologically proven OSCC of the gingivobuccal sulcus with radiographic infiltration of the mandible were included. The surgical specimens were decalcified and serially sectioned. Each section was stained with hematoxylin and eosin and was screened for the presence of perineural invasion and spread. Results : Twenty-five specimens showed perineural infiltration but none of the cases showed perineural spread along the inferior alveolar canal. Also, not all cases showed any neurologic deficit. Follow-up of these cases showed early recurrence (6-8 months) in the study group.
  
  
  CONCLUSIONS
  Perineural infiltration is present in OSCC but perineural spread along the inferior alveolar canal is absent. It is a bad prognostic indicator.
authors.affiliation: Department of Oral and MaxilloFacial Surgery, Sharad Pawar Dental College, Sawangi Meghe, Wardha, Maharashtra, India.
authors.forename: N A
authors.initials: NA
authors.lastname: Agni
authors.forename: Gsv
authors.initials: G
authors.lastname: Prasad
authors.forename: R M
authors.initials: RM
authors.lastname: Borle
authors.forename: S
authors.initials: S
authors.lastname: Shukla
authors.forename: S
authors.initials: S
authors.lastname: Grover
authors.forename: S
authors.initials: S
authors.lastname: Korde
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D005887:Gingival Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology*; D011379:Prognosis