title: Portal hemodynamics and clinical outcomes of patients with gastric varices after balloon-occluded retrograde transvenous obliteration.
abstract: BACKGROUND
  Long-term hemodynamic effects and clinical outcomes after balloon-occluded retrograde transvenous obliteration (B-RTO) remain unclear. The purpose of this study was to evaluate long-term clinical results and effects on portal hemodynamics after B-RTO for the treatment of gastric varices with spontaneous gastrorenal shunt.
  
  
  METHODS
  A total of 21 patients with cirrhosis and gastric varices treated by B-RTO were evaluated. The cumulative survival rate was calculated, portal blood flow was measured by Doppler ultrasonography, and liver function was estimated on the basis of Child-Pugh classification before and 1 year after B-RTO.
  
  
  RESULTS
  Gastric varices disappeared or decreased markedly in size in all patients. Overall cumulative survival rates at 1, 3 and 5 years were 90.48, 71.11 and 53.71%, respectively. Portal blood flow increased significantly from 681.9 +/- 294.9 to 837.0 +/- 279.1 ml/min (P = 0.0125) after B-RTO. Child-Pugh score was not significantly changed (P = 0.755) after obliteration, but serum albumin was elevated significantly from 3.49 +/- 0.49 to 3.75 +/- 0.53 g/dl (P = 0.0459). The ascites score was significantly increased (P = 0.0455) after B-RTO, but all cases of ascites could be controlled with medication.
  
  
  CONCLUSIONS
  Balloon-occluded retrograde transvenous obliteration is a safe and effective treatment for gastric varices with gastrorenal shunt. Portal blood flow and serum albumin parameters are increased, and liver function is unchanged after B-RTO.
authors.affiliation: Department of Gastroenterology, Funabashi Municipal Medical Center, Chiba, Japan. akiyoshi_81@hotmail.com
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Kasuga
authors.forename: Hideaki
authors.initials: H
authors.lastname: Mizumoto
authors.forename: Shoichi
authors.initials: S
authors.lastname: Matsutani
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Endo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ando
authors.forename: Seigo
authors.initials: S
authors.lastname: Yukisawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
mesh_terms: D000328:Adult; D000368:Aged; D021721:Balloon Occlusion / Q000379:methods*; D004932:Esophageal and Gastric Varices / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011168:Portal System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color