title: Pathophysiology of migraine chronification.
abstract: Migraine is a prevalent, disabling, undiagnosed and undertreated disease in neurological practice. It is a chronic, recurrent disorder with episodic manifestations that are progressive in some individuals with clinical, physiological and anatomical bases. Progression may be due to mechanisms generating the migraine attacks or to the activation generated by the attacks. Potentially remediable risk factors for chronification include frequency of migraine attacks, obesity, excessive use of medications, caffeine overuse, stressful life events, depression, sleep disorders and cutaneous allodynia.
authors.affiliation: Neurological Department, Cardinal Massaia Hospital, Via Conte Verde 215, 14100, Asti, Italy. aguggiamarco@tiscali.it
authors.forename: M
authors.initials: M
authors.lastname: Aguggia
authors.forename: M G
authors.initials: MG
authors.lastname: Saracco
mesh_terms: D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D008881:Migraine Disorders / Q000209:etiology* / Q000503:physiopathology*; D012307:Risk Factors
references.citation: Lancet Neurol. 2006 Feb;5(2):148-157
references.pmid: 16426991
references.citation: Headache. 2008 Jan;48(1):16-25
references.pmid: 18184281
references.citation: Curr Opin Neurol. 2002 Jun;15(3):287-95
references.pmid: 12045727
references.citation: Neurology. 1996 Oct;47(4):871-5
references.pmid: 8857711
references.citation: Headache. 2002 Jul-Aug;42(7):663-74
references.pmid: 12482221
references.citation: PLoS Med. 2006 Oct;3(10):e402
references.pmid: 17048979
references.citation: Neurology. 1994 Jun;44(6 Suppl 4):S24-39
references.pmid: 8008223
references.citation: Headache. 1987 Feb;27(2):102-6
references.pmid: 3570762
references.citation: Cephalalgia. 2006 Sep;26(9):1080-8
references.pmid: 16919058
references.citation: Cephalalgia. 2007 Apr;27(4):325-9
references.pmid: 17376108
references.citation: Headache. 2001 Jul-Aug;41(7):629-37
references.pmid: 11554950
references.citation: Neurology. 2009 Feb 3;72(5 Suppl):S3-7
references.pmid: 19188564
references.citation: Brain. 2003 Sep;126(Pt 9):2009-15
references.pmid: 12821515
references.citation: Ann Neurol. 2000 May;47(5):614-24
references.pmid: 10805332
references.citation: Neurology. 2003 Jul 22;61(2):160-4
references.pmid: 12874392
references.citation: Neurology. 1993 Jun;43(6 Suppl 3):S21-5
references.pmid: 8502383
references.citation: Pain. 2002 Dec;100(3):213-217
references.pmid: 12467992
references.citation: N Engl J Med. 2002 Jan 24;346(4):257-70
references.pmid: 11807151
references.citation: J Anat. 2001 Jan;198(Pt 1):29-35
references.pmid: 11215764
references.citation: Neuroscience. 2001;106(4):793-800
references.pmid: 11682164
references.citation: Neurology. 2007 Jan 30;68(5):343-9
references.pmid: 17261680
references.citation: Brain. 2000 Aug;123 ( Pt 8):1703-9
references.pmid: 10908199
references.citation: Headache. 2008 Jan;48(1):58-66
references.pmid: 18184287
references.citation: Pain. 2003 Nov;106(1-2):81-9
references.pmid: 14581114
references.citation: Neurology. 2000 Sep 12;55(5):629-35
references.pmid: 10980724
references.citation: JAMA. 2004 Jan 28;291(4):427-34
references.pmid: 14747499
references.citation: Cephalalgia. 2007 Jun;27(6):557-60
references.pmid: 17598792
references.citation: Neurology. 2002 Oct 8;59(7):1011-4
references.pmid: 12370454
references.citation: Neurology. 2008 Sep 9;71(11):848-55
references.pmid: 18779513