Biodegradable and pH-sensitive polymersome with tuning permeable membrane for drug delivery carrier.
Novel biodegradable and pH-sensitive polymersomes prepared from poly(ethylene glycol) and poly(d,l-lactide) grafted poly(beta-amino ester) exhibit pH dependent permeability on hydrophilic solutes of which permeability is determined by the packing state of poly(d,l-lactide) membrane followed by ionization of poly(beta-amino ester) inducing loosely packed membrane formation from well-ordered packing.
Kim
Min Sang
MS
Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Korea.
Lee
Doo Sung
DS
D020341:Absorbable Implants; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D013499:Surface Properties
D004337:Drug Carriers; D008567:Membranes, Artificial; D011108:Polymers