Regulation of actin cytoskeleton dynamics in cells.
The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities, and malfunction of cytoskeletal proteins results in various human diseases. The transition between two forms of actin, monomeric or G-actin and filamentous or F-actin, is tightly regulated in time and space by a large number of signaling, scaffolding and actin-binding proteins (ABPs). New ABPs are constantly being discovered in the post-genomic era. Most of these proteins are modular, integrating actin binding, protein-protein interaction, membrane-binding, and signaling domains. In response to extracellular signals, often mediated by Rho family GTPases, ABPs control different steps of actin cytoskeleton assembly, including filament nucleation, elongation, severing, capping, and depolymerization. This review summarizes structure-function relationships among ABPs in the regulation of actin cytoskeleton assembly.
Lee
Sung Haeng
SH
Chosun University School of Medicine, Department of Cellular and Molecular Medicine, Gwangju 501-759, Korea. sunglee@chosun.ac.kr
Dominguez
Roberto
R
D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D000199:Actins; D008840:Microfilament Proteins
Structure. 2001 Jul 3;9(7):597-604
11470434
Science. 2001 Jul 27;293(5530):708-11
11474115
Curr Opin Cell Biol. 2004 Feb;16(1):99-105
15037312
J Biol Chem. 2001 Dec 7;276(49):45555-63
11579089
J Biol Chem. 2001 Oct 26;276(43):40096-103
11489888
Eur J Biochem. 1995 Jun 1;230(2):658-65
7607240
Structure. 2007 Jul;15(7):839-52
17540576
Biochim Biophys Acta. 2006 Aug;1761(8):897-912
16938488
Nature. 2009 Jan 22;457(7228):441-5
19158791
Nature. 1993 Aug 19;364(6439):685-92
8395021
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17027-32
15569942
Science. 2008 Apr 11;320(5873):239-43
18403713
FEBS Lett. 1987 Sep 14;221(2):391-6
3622778
Zygote. 1993 Nov;1(4):325-31
8081830
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6181-6
9600938
Curr Biol. 1998 Sep 24;8(19):R674-5
9768350
Curr Top Dev Biol. 2004;63:145-88
15536016
J Biol Chem. 1995 Dec 8;270(49):29071-4
7493928
J Cell Biol. 2000 Mar 6;148(5):843-8
10704435
Nature. 1989 Mar 16;338(6212):259-62
2493582
Curr Opin Cell Biol. 1999 Feb;11(1):117-21
10047519
Trends Cell Biol. 2008 Feb;18(2):52-60
18215522
J Cell Sci. 2007 Dec 15;120(Pt 24):4302-9
18029399
Ann N Y Acad Sci. 2007 Sep;1112:76-85
17947588
Cell. 2006 Jan 27;124(2):423-35
16439214
Mol Cell Biol. 1996 Jun;16(6):2689-99
8649376
Curr Opin Cell Biol. 1994 Feb;6(1):105-9
8167015
Trends Cell Biol. 2008 Oct;18(10):494-504
18774717
Biochem Biophys Res Commun. 1986 Apr 14;136(1):72-9
3010978
Nature. 2001 May 10;411(6834):215-9
11346801
Sci STKE. 2004 May 04;2004(232):pl9
15138329
Cell Mol Biol Lett. 2001;6(2):234
11544685
J Mol Biol. 2005 Aug 19;351(3):653-61
16023669
FEBS Lett. 2002 Feb 20;513(1):98-106
11911887
Annu Rev Biophys Biomol Struct. 2000;29:545-76
10940259
J Cell Biol. 2008 Jul 14;182(1):51-9
18625842
Nature. 2002 Dec 12;420(6916):629-35
12478284
Eur J Biochem. 2004 May;271(10):1873-84
15128297
J Cell Sci. 2004 Jul 1;117(Pt 15):3077-86
15226389
EMBO J. 2006 Jun 21;25(12):2889-97
16763557
Cell. 1992 Aug 7;70(3):389-99
1643657
Cell. 2007 Oct 19;131(2):337-50
17956734
J Biol Chem. 2003 Sep 5;278(36):34172-80
12813032
EMBO J. 2007 Jul 25;26(14):3484-93
17581628
J Muscle Res Cell Motil. 2004;25(4-5):351-8
15548864
FEBS Lett. 2002 Feb 20;513(1):92-7
11911886
Nat Rev Mol Cell Biol. 2007 Jan;8(1):37-48
17183359
Biochim Biophys Acta. 2007 May;1773(5):642-52
16926057
Science. 2001 Nov 23;294(5547):1679-84
11721045
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):29-34
9874766
J Mol Biol. 2005 Apr 22;348(1):151-65
15808860
J Muscle Res Cell Motil. 1989 Aug;10(4):280-9
2671039
J Cell Biol. 2002 Apr 15;157(2):243-51
11956227
Structure. 2003 Jun;11(6):615-25
12791251
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3739-44
10097107
Mol Cell Biol Res Commun. 1999 May;1(2):87-94
10356356
Nature. 1998 Jun 25;393(6687):805-9
9655397
Mol Cell Biol. 1995 Apr;15(4):1942-52
7891688
Development. 1994 Dec;120(12):3367-77
7821209
Nature. 1990 Sep 6;347(6288):44-9
2395461
Mol Biol Cell. 1998 Aug;9(8):1951-9
9693358
J Biol Chem. 2008 Apr 11;283(15):9814-9
18283104
Muscle Nerve. 2001 Dec;24(12):1575-94
11745966
Biochemistry. 2006 Nov 14;45(45):13576-84
17087511
EMBO J. 2006 Jun 21;25(12):2898-910
16763559
Nature. 1998 Jun 25;393(6687):809-12
9655398
Annu Rev Cell Dev Biol. 2003;19:287-332
14570572
J Mol Biol. 2008 Feb 15;376(2):317-24
18164029
Mol Biol Cell. 2002 May;13(5):1512-21
12006649
EMBO J. 1997 Sep 15;16(18):5520-30
9312011
Cell. 2003 Feb 21;112(4):453-65
12600310
Curr Biol. 2003 Apr 1;13(7):534-45
12676083
J Struct Biol. 2006 Aug;155(2):230-8
16698282
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8003-8
12048248
Curr Biol. 1994 Jan 1;4(1):79-81
7922321
J Cell Biol. 1999 Mar 22;144(6):1235-44
10087266
Science. 2004 Jan 23;303(5657):495-9
14645856
Protein Sci. 2002 Jun;11(6):1285-99
12021428
Cell. 1992 Aug 7;70(3):401-10
1643658
J Cell Biol. 1994 Oct;127(1):107-15
7929556
Curr Biol. 2001 Oct 30;11(21):1645-55
11696321
J Struct Biol. 2006 Aug;155(2):195-201
16684607
Nature. 1993 Oct 28;365(6449):810-6
8413665
J Biol Chem. 1999 Dec 10;274(50):35375-80
10585405
Structure. 2000 May 15;8(5):481-91
10801490
Proteins. 2000 Nov 15;41(3):374-84
11025548
Cell. 2004 May 28;117(5):611-23
15163409
Nat Rev Mol Cell Biol. 2006 Jun;7(6):404-14
16723976
EMBO J. 2007 Oct 31;26(21):4597-606
17914456
Curr Biol. 1998 Dec 17-31;8(25):1347-56
9889097
Dev Biol. 2004 Jan 1;265(1):23-32
14697350
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17117-22
17942696
Annu Rev Cell Dev Biol. 1999;15:185-230
10611961
J Cell Sci. 2003 Jun 15;116(Pt 12):2577-83
12734400
EMBO J. 2007 Nov 14;26(22):4788-800
17948057
Structure. 2007 Feb;15(2):145-55
17292833
J Mol Biol. 2000 Mar 24;297(2):465-80
10715214
Science. 1999 Aug 6;285(5429):895-8
10436159
Curr Biol. 2009 Jan 27;19(2):95-107
19150238
Physiol Rev. 2001 Jul;81(3):1353-92
11427698
Biochem J. 1996 Sep 15;318 ( Pt 3):753-7
8836115
Annu Rev Plant Biol. 2006;57:109-25
16669757
Trends Cell Biol. 2006 Oct;16(10):493-8
16949824
Adv Protein Chem. 2005;70:203-46
15837517
Structure. 2004 Jun;12(6):999-1013
15274920
J Biol Chem. 2004 Sep 17;279(38):40091-9
15252009
Nat Struct Biol. 1995 Sep;2(9):715-8
7552736
Curr Biol. 2003 Aug 5;13(15):1335-40
12906795
J Biol Chem. 1999 Aug 13;274(33):23549-57
10438535
Structure. 2007 Jul;15(7):751-3
17637334
FEBS Lett. 1995 Aug 1;369(1):27-33
7641878
Semin Liver Dis. 2002 Aug;22(3):263-76
12360420
Curr Biol. 2000 May 18;10(10):576-85
10837222
Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16644-9
16275905
Science. 1998 Nov 27;282(5394):1717-21
9831565
FEBS Lett. 2003 Sep 25;552(2-3):75-81
14527663
J Cell Biol. 1994 Jul;126(2):433-43
8034744
Trends Biochem Sci. 2004 Nov;29(11):572-8
15501675
Mol Biol Cell. 2002 Nov;13(11):3811-21
12429826
Nature. 2000 Dec 7;408(6813):732-5
11130076
EMBO J. 2008 Nov 19;27(22):2943-54
18923426
J Biol Chem. 2002 Nov 8;277(45):43089-95
12207032
Dev Cell. 2004 Oct;7(4):571-83
15469845
Science. 2002 Jul 26;297(5581):612-5
12052901
Biochemistry. 2002 May 7;41(18):5765-75
11980480
Nat Struct Biol. 1997 May;4(5):366-9
9145106
Structure. 1999 Dec 15;7(12):1539-46
10647184
Cell. 2007 May 18;129(4):761-72
17512409
J Formos Med Assoc. 2008 Jan;107(1):64-7
18218579
Nat Struct Biol. 1998 Sep;5(9):787-92
9731773
Ann N Y Acad Sci. 2007 Sep;1112:86-94
17468236
J Mol Biol. 1997 Oct 31;273(3):740-51
9356261
Neuroscientist. 2006 Apr;12(2):107-18
16514008
J Cell Biol. 1991 Oct;115(1):267-77
1833409
Annu Rev Cell Dev Biol. 2003;19:541-64
14570581
Nat Cell Biol. 2002 Dec;4(12):E292-4
12461536
Prog Mol Subcell Biol. 1999;22:201-29
10081071
Nat Struct Biol. 1997 Sep;4(9):708-12
9302997
Cell Host Microbe. 2007 Apr 19;1(2):95-107
18005688
Cell. 2008 Mar 7;132(5):807-17
18329367
J Biol Chem. 2006 Nov 17;281(46):35347-58
17003044
Nat Cell Biol. 1999 Sep;1(5):253-9
10559936
EMBO Rep. 2004 Mar;5(3):250-5
14993925
J Cell Biol. 2007 Mar 26;176(7):953-64
17371834
J Biol Chem. 2004 Apr 9;279(15):14929-36
14752106
J Mol Biol. 2003 Aug 29;331(5):967-72
12927533
Nature. 2005 Feb 3;433(7025):488-94
15635372
J Mol Biol. 2008 Mar 21;377(2):395-409
18258262
Biochim Biophys Acta. 2000 Mar 17;1496(1):3-22
10722873
Nature. 2005 Jan 27;433(7024):382-8
15674283
EMBO J. 2006 Mar 22;25(6):1184-95
16511569
Cell. 2004 Mar 5;116(5):711-23
15006353
Annu Rev Biochem. 2007;76:593-627
17373907
J Biol Chem. 2003 Dec 5;278(49):49031-43
14506234
Annu Rev Cell Dev Biol. 2005;21:695-718
16212512
Nature. 2005 Dec 1;438(7068):590-6
16319878
Biophys J. 2009 Jan;96(1):180-91
19134474
Crit Rev Biochem Mol Biol. 2009 Nov-Dec;44(6):351-66
19874150
J Mol Biol. 2003 May 23;329(1):15-33
12742015
J Biol Chem. 2004 May 28;279(22):23637-45
15039431
EMBO J. 2005 Jan 26;24(2):240-50
15635447
Curr Biol. 2007 Apr 3;17(7):579-91
17398099
Annu Rev Cell Biol. 1994;10:31-54
7888179
Science. 2000 Oct 27;290(5492):801-6
11052943
Cell. 2004 Jul 23;118(2):203-16
15260990
PLoS One. 2008;3(10):e3588
18974786
Nat Rev Mol Cell Biol. 2008 Jun;9(6):446-54
18464790
Annu Rev Biochem. 2004;73:209-39
15189141
Curr Opin Neurobiol. 1997 Feb;7(1):81-6
9039798
J Cell Biol. 2001 Feb 5;152(3):579-94
11157984
Science. 2007 Jun 22;316(5832):1749-52
17588931
EMBO J. 1997 Jun 2;16(11):3044-56
9214622