Associations between IQ, total and regional brain volumes, and demography in a large normative sample of healthy children and adolescents.
In the course of efforts to establish quantitative norms for healthy brain development by magnetic resonance imaging (MRI) (Brain Development Cooperative Group, 2006), previously unreported associations of parental education and temporal and frontal lobe volumes with full scale IQ and its verbal and performance subscales were discovered. Our findings were derived from the largest, most representative MRI sample to date of healthy children and adolescents, ages 4 years 10 months to 18 years 4 months. We first find that parental education has a strong association with IQ in children that is not mediated by total or regional brain volumes. Second, we find that our observed correlations between temporal gray matter, temporal white matter and frontal white matter volumes with full scale IQ, between 0.14 to 0.27 in children and adolescents, are due in large part to their correlations with performance IQ and not verbal IQ. The volumes of other lobar gray and white matter, subcortical gray matter (thalamus, caudate nucleus, putamen, and globus pallidus), cerebellum, and brainstem do not contribute significantly to IQ variation. Third, we find that head circumference is an insufficient index of cerebral volume in typically developing older children and adolescents. The relations between total and regional brain volumes and IQ can best be discerned when additional variables known to be associated with IQ, especially parental education and other demographic measures, are considered concurrently.
Lange
Nicholas
N
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. nlange@hms.harvard.edu
Froimowitz
Michael P
MP
Bigler
Erin D
ED
Lainhart
Janet E
JE
D000293:Adolescent; D001244:Association; D001837:Body Weights and Measures / Q000379:methods; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004522:Educational Status; D005260:Female; D007839:Functional Laterality; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007360:Intelligence; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests
Pediatr Res. 2008 Mar;63(3):308-14
18287970
Hum Brain Mapp. 2005 Oct;26(2):139-47
15858815
Neuroimage. 2006 Mar;30(1):184-202
16376577
J Pediatr. 1974 Oct;85(4):482-9
4443855
Psychiatry Res. 1997 Mar 14;74(1):1-12
10710158
Am J Med Genet A. 2006 Nov 1;140(21):2257-74
17022081
Brain. 2006 Feb;129(Pt 2):386-98
16339797
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11650-5
11573002
Acta Paediatr Scand. 1988 May;77(3):374-9
3389130
Am J Psychiatry. 1993 Jan;150(1):130-4
8417555
Cereb Cortex. 1998 Jun;8(4):372-84
9651132
Annu Rev Neurosci. 2005;28:1-23
15651931
J Child Psychol Psychiatry. 2003 Nov;44(8):1092-115
14626453
Bioessays. 2007 Oct;29(10):962-73
17876781
J Neurosci. 2006 Oct 4;26(40):10235-42
17021179
Hum Brain Mapp. 2009 Jan;30(1):163-74
18041741
Intelligence. 2009 Mar;37(2):145-155
20161325
Arch Gen Psychiatry. 2005 Dec;62(12):1366-76
16330725
Neuroimage. 2006 Jul 1;31(3):1359-65
16513370
Nat Neurosci. 2002 Feb;5(2):83-4
11818967
Neurosci Lett. 2006 Sep 11;405(1-2):34-9
16857316
Neuroimage. 2003 Sep;20(1):202-15
14527581
Ann N Y Acad Sci. 2004 Jun;1021:431-5
15251923
Am J Dis Child. 1976 May;130(5):481-7
1274898
Nat Neurosci. 1999 Oct;2(10):861-3
10491603
Neuroimage. 2006 Jul 1;31(3):1366-79
16540350
Neuroimage. 2004 Nov;23(3):800-5
15528081
Neurology. 2002 Jul 23;59(2):175-83
12136053
Cereb Cortex. 1996 Jul-Aug;6(4):551-60
8670681
Neurosci Biobehav Rev. 2006;30(6):718-29
16887188
Neuroimage. 2006 Jul 1;31(3):993-1003
16624590
J Am Acad Child Adolesc Psychiatry. 1996 Apr;35(4):530-6
8919716
Nature. 2006 Mar 30;440(7084):676-9
16572172
Neuroimage. 2004 Sep;23(1):425-33
15325390
Biometrics. 2005 Dec;61(4):1037-48
16401277
Behav Genet. 2000 Nov;30(6):487-95
11523707
Nat Neurosci. 2003 Mar;6(3):309-15
12548289
J Int Neuropsychol Soc. 2007 Sep;13(5):729-46
17511896
Arch Dis Child Fetal Neonatal Ed. 2001 Jan;84(1):F23-7
11124919
Brain. 2004 Feb;127(Pt 2):321-9
14645144
Neuropediatrics. 2002 Oct;33(5):239-41
12536365
Brain. 1996 Oct;119 ( Pt 5):1763-74
8931596
Pediatrics. 2006 Oct;118(4):1486-92
17015539