title: The birthday of a new syndrome: IgG4-related diseases constitute a clinical entity.
abstract: IgG4-related disease is a distinct clinical entity, whose characteristic features are the following; Serum IgG4 is prominently elevated, IgG4-positive plasma cells infiltrate in involved tissues, various mass-forming lesions with fibrosis develop in a timely and spatial manner and the response to corticosteroids is prompt and good. IgG4-related diseases mainly target two organs. One is the pancreas (autoimmune pancreatitis; AIP), and the other comprises the lacrimal and salivary glands, the clinical phenotype is Mikulicz's disease (MD). MD has long been considered a manifestation of Sjögren's syndrome (SS). However, we noticed several clinical differences in case of MD from SS; no deflection of female sex differences, mild sicca syndrome, good response to corticosteroids, no positivity of anti-SS-A/SS-B antibodies. In addition, elevated level of serum IgG4 and abundant infiltration of plasma cells expressing IgG4 were reported in MD patients. Those are common features of IgG4-related diseases. MD often coexisted with IgG4-related diseases such as AIP, retroperitoneal fibrosis, and IgG4-associated nephropathy. Based on those findings, it has been considered to recognize IgG4-related diseases including MD as a new clinical entity. The etiology of IgG4-related systemic diseases remains to be elucidated. It is necessary to accumulate and analyze larger data from patients worldwide.
authors.affiliation: First Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan. htakahas@sapmed.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Motohisa
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Chisako
authors.initials: C
authors.lastname: Suzuki
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Naishiro
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Imai
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis*; D007074:Immunoglobulin G / Q000097:blood*; D007765:Lacrimal Apparatus / Q000473:pathology; D008882:Mikulicz' Disease / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D010195:Pancreatitis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D012469:Salivary Glands / Q000276:immunology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D013577:Syndrome
chemical_list: D007074:Immunoglobulin G