Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls.
BACKGROUND
There is a decreased serotonergic function in impulsive aggression and borderline personality disorder (BPD), and genetic association studies suggest a role of serotonergic genes in impulsive aggression and BPD. Only one study has analyzed the association between the tryptophan-hydroxylase 2 (TPH2) gene and BPD. A TPH2 "risk" haplotype has been described that is associated with anxiety, depression and suicidal behavior.


METHODS
We assessed the relationship between the previously identified "risk" haplotype at the TPH2 locus and BPD diagnosis, impulsive aggression, affective lability, and suicidal/parasuicidal behaviors, in a well-characterized clinical sample of 103 healthy controls (HCs) and 251 patients with personality disorders (109 with BPD). A logistic regression including measures of depression, affective lability and aggression scores in predicting "risk" haplotype was conducted.


RESULTS
The prevalence of the "risk" haplotype was significantly higher in patients with BPD compared to HCs. Those with the "risk" haplotype have higher aggression and affect lability scores and more suicidal/parasuicidal behaviors than those without it. In the logistic regression model, affect lability was the only significant predictor and it correctly classified 83.1% of the subjects as "risk" or "non-risk" haplotype carriers.


CONCLUSIONS
We found an association between the previously described TPH2 "risk" haplotype and BPD diagnosis, affective lability, suicidal/parasuicidal behavior, and aggression scores.
Perez-Rodriguez
M Mercedes
MM
Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box # 1230, One Gustave L. Levy Place, New York, NY 10029, USA.
Weinstein
Shauna
S
New
Antonia S
AS
Bevilacqua
Laura
L
Yuan
Qiaoping
Q
Zhou
Zhifeng
Z
Hodgkinson
Colin
C
Goodman
Marianne
M
Koenigsberg
Harold W
HW
Goldman
David
D
Siever
Larry J
LJ
D000328:Adult; D000374:Aggression / Q000523:psychology*; D001883:Borderline Personality Disorder / Q000208:ethnology / Q000235:genetics* / Q000523:psychology*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012737:Sex Factors; D013406:Suicide, Attempted / Q000523:psychology; D011795:Surveys and Questionnaires; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D044465:White People / Q000208:ethnology
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase
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