title: Early APV chronic blocked alters experience-dependent plasticity of auditory spatial representation in rat auditory cortical neurons.
abstract: Development of auditory function can be affected by environment and experience. In this study, we investigated whether the NMDA receptor mediates the plasticity of auditory spatial representation during development of the rat auditory cortex. We found that early auditory experience significantly increased the auditory spatial sensitivity of A1 neurons and induced training-dependent plasticity. Implantation of Elvax-APV in the auditory cortex gradually reduced the auditory spatial sensitivity of A1 neurons and blocked the auditory spatial plasticity induced by early auditory experience. These results indicate that the NMDA receptor has a key role in experience-dependent plasticity of auditory cortical circuits immediately after birth.
authors.affiliation: School of Life Science, Institute of Cognitive Neuroscience, Key Laboratory of Brain Functional Genomics, Ministry of Education of China, East China Normal University, Shanghai, China.
authors.forename: Yilei
authors.initials: Y
authors.lastname: Cui
authors.forename: Rui
authors.initials: R
authors.lastname: Cai
authors.forename: Jiping
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Pan
authors.forename: Xinde
authors.initials: X
authors.lastname: Sun
mesh_terms: D000161:Acoustic Stimulation; D000375:Aging; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D004343:Drug Implants; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D008839:Microelectrodes; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004343:Drug Implants; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine