Reduction in inflammation in the footpad of carrageenan treated mice following the topical administration of anti-TNF molecules formulated in a micro-emulsion.
Water-in-oil micro-emulsions (ME) have been shown to have the ability to deliver water-soluble peptides and proteins into the skin. Topical administration of these formulations represents an ideal means of device-free delivery of these pharmaceutical agents. Topically administered anti-tumor necrosis factor (TNF) monoclonal antibodies formulated within a water-in-oil micro-emulsion were found to have similar pharmaceutical activity to control formulations that were administered by injection. This form of delivery presents itself as an exciting, pain-free and device-free delivery system for administration of protein pharmaceuticals and as such has enormous potential for the delivery of peptides and protein into the dermal layer of the skin.
Himes
R
R
Apollo Life Sciences Pty Ltd, Unit5/15 Gibbes St, Chatswood, NSW 2067, Australia.
Lee
S
S
McMenigall
K
K
Russell-Jones
G J
GJ
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000276:immunology / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002351:Carrageenan; D004655:Emulsions; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D012867:Skin / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D004655:Emulsions; D014409:Tumor Necrosis Factor-alpha; D002351:Carrageenan