G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve.
The growth differential factor-9 (GDF-9) gene, an oocyte-specific factor, was screened in 106 Chinese women with diminished ovarian reserve (DOR), and three single-nucleotide polymorphisms, c.G169A, c.C447T and c.G546A, were detected. We found GDF-9 c.G546A, but not c.G169A or c.C447T, to be correlated with the poor ovarian stimulation and in vitro fertilization outcomes in women with DOR.
Wang
Ting-Ting
TT
Department of Reproductive Endocrinology, Zhejiang Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Wu
Yan-Ting
YT
Dong
Min-Yue
MY
Sheng
Jian-Zhong
JZ
Leung
Peter C K
PC
Huang
He-Feng
HF
D000328:Adult; D002452:Cell Count; D005260:Female; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease; D055429:Growth Differentiation Factor 9 / Q000235:genetics*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D020125:Mutation, Missense / Q000502:physiology; D010053:Ovary / Q000473:pathology; D010062:Ovulation Induction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
D055429:Growth Differentiation Factor 9