title: 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.
abstract: The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02115, USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Ahmadiyeh
authors.forename: Mark M
authors.initials: MM
authors.lastname: Pomerantz
authors.forename: Chiara
authors.initials: C
authors.lastname: Grisanzio
authors.forename: Paula
authors.initials: P
authors.lastname: Herman
authors.forename: Li
authors.initials: L
authors.lastname: Jia
authors.forename: Vanessa
authors.initials: V
authors.lastname: Almendro
authors.forename: Housheng Hansen
authors.initials: HH
authors.lastname: He
authors.forename: Myles
authors.initials: M
authors.lastname: Brown
authors.forename: X Shirley
authors.initials: XS
authors.lastname: Liu
authors.forename: Matt
authors.initials: M
authors.lastname: Davis
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Caswell
authors.forename: Christine A
authors.initials: CA
authors.lastname: Beckwith
authors.forename: Adam
authors.initials: A
authors.lastname: Hills
authors.forename: Laura
authors.initials: L
authors.lastname: Macconaill
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Coetzee
authors.forename: Meredith M
authors.initials: MM
authors.lastname: Regan
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Freedman
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D045744:Cell Line, Tumor; D002898:Chromosomes, Human, Pair 8; D003110:Colonic Neoplasms / Q000235:genetics*; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D056426:Genetic Loci; D015894:Genome, Human; D006801:Humans; D009928:Organ Specificity; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012307:Risk Factors
chemical_list: C000715470:MAS1 protein, human; C489427:MYC protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc
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