title: Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.
abstract: A recent pediatric-focused genome-wide association study has implicated three novel susceptibility loci for Crohn' disease (CD).We aimed to investigate whether the three recently reported and other previously reported genes/loci were also associated with CD in Canadian children. A case-control design was implemented at three pediatric gastroenterology clinics in Canada. Children <19 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in 19 reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. A total of 563 cases and 553 controls were studied. The mean (+/-SD) age of the cases was 12.3 (+/-3.2) years. Most cases were male (56.0%), had ileo-colonic disease (L3 +/- L4, 48.8%) and inflammatory behavior (B1 +/- p, 87.9%) at diagnosis. Allelic association analysis (two-tailed) showed that 8 of the 19 targeted SNPs were significantly associated with overall susceptibility for CD. Associations with one additional SNP was borderline non-significant. Significantly associated SNPs included SNPs rs1250550 (p = 0.026) and rs8049439 (p = 0.04), recently reported to be specifically associated with pediatric-onset CD.Based on the results, we confirmed associations between two of the three novel pediatric-CD loci and other regions reported for associations with either pediatric and/or adult-onset CD.
authors.affiliation: Department of Pediatrics, University of Montreal, Montreal, QC, Canada. devendra.amre@umontreal.ca
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Amre
authors.forename: David R
authors.initials: DR
authors.lastname: Mack
authors.forename: Kenneth
authors.initials: K
authors.lastname: Morgan
authors.forename: David
authors.initials: D
authors.lastname: Israel
authors.forename: Colette
authors.initials: C
authors.lastname: Deslandres
authors.forename: Ernest G
authors.initials: EG
authors.lastname: Seidman
authors.forename: Phlippe
authors.initials: P
authors.lastname: Lambrette
authors.forename: Irina
authors.initials: I
authors.lastname: Costea
authors.forename: Alfreda
authors.initials: A
authors.lastname: Krupoves
authors.forename: Houda
authors.initials: H
authors.lastname: Fegury
authors.forename: Jinsong
authors.initials: J
authors.lastname: Dong
authors.forename: Zia
authors.initials: Z
authors.lastname: Xhu
authors.forename: Guy
authors.initials: G
authors.lastname: Grimard
authors.forename: Emile
authors.initials: E
authors.lastname: Levy
mesh_terms: D000328:Adult; D000483:Alleles; D002170:Canada; D002648:Child; D003424:Crohn Disease / Q000175:diagnosis / Q000235:genetics*; D016678:Genome; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012106:Research
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