Discovery of new 1,3,5-triazine scaffolds with potent activity against Mycobacterium tuberculosis H37Rv.
A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to moderate activity with an MIC in the range 1.56-3.12 microg/mL and most of them were found to be nontoxic against VERO cells and MBMDMQs (mouse bone marrow derived macrophages). This is for the first time that 2,4,6-trisubstituted-1,3,5-triazines were identified as a potent inhibitors of M. tuberculosis H37Rv.
Sunduru
Naresh
N
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226001, India.
Gupta
Leena
L
Chaturvedi
Vinita
V
Dwivedi
Richa
R
Sinha
Sudhir
S
Chauhan
Prem M S
PM
D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001854:Bone Marrow Cells / Q000166:cytology; D002522:Chlorocebus aethiops; D055808:Drug Discovery; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013057:Spectrum Analysis; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D014709:Vero Cells
D000995:Antitubercular Agents; D014227:Triazines