title: [Mechanism of development of epidemic process of group A streptococcal infection in children collectives].
abstract: OBJECTIVE
  To study the characteristics of group A streptococcal infection epidemic process in children aged 12 - 14 years arrived to summer camp "Orlenok" (Tuapse) from different regions of Russia.
  
  
  METHODS
  Epidemiological (retrospective analysis of incidence of acute respiratory infections, tonsillitis, and scarlet fever), microbiological (isolation and identification of group A streptococci [GAS]), and molecular biological (pulse-electrophoresis, analysis of spe and emm genes) methods were used for the study. Objects of the study were GAS strains isolated from patients and carriers.
  
  
  RESULTS
  Performed genotyping showed that cases of GAS infection in newly formed children collectives were caused by 2 - 3 epidemically important clones, which were genotypically heterogenous.
  
  
  CONCLUSIONS
  Performed molecular biologic studies demonstrated polyclonal structure of GAS that determines the features of development of epidemic process.
authors.forename: N I
authors.initials: NI
authors.lastname: Briko
authors.forename: L A
authors.initials: LA
authors.lastname: Riapis
authors.forename: N F
authors.initials: NF
authors.lastname: Dmitrieva
authors.forename: A S
authors.initials: AS
authors.lastname: Eshchina
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kirillov
authors.forename: N V
authors.initials: NV
authors.lastname: Torchinskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Gerasimov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhukov
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D002353:Carrier State; D002648:Child; D004196:Disease Outbreaks; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D015994:Incidence; D007899:Leisure Activities; D017720:Molecular Epidemiology; D012426:Russia / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology*; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D005098:Exotoxins; C027951:erythrogenic toxin; C014689:streptococcal M protein