Targetfinder.org: a resource for systematic discovery of transcription factor target genes.
Targetfinder.org (http://targetfinder.org/) provides a web-based resource for finding genes that show a similar expression pattern to a group of user-selected genes. It is based on a large-scale gene expression compendium (>1200 experiments, >13,000 genes). The primary application of Targetfinder.org is to expand a list of known transcription factor targets by new candidate target genes. The user submits a group of genes (the 'seed'), and as a result the web site provides a list of other genes ranked by similarity of their expression to the expression of the seed genes. Additionally, the web site provides information on a recovery/cross-validation test to check for consistency of the provided seed and the quality of the ranking. Furthermore, the web site allows to analyse affinities of a selected transcription factor to the promoter regions of the top-ranked genes in order to select the best new candidate target genes for further experimental analysis.
Kiełbasa
Szymon M
SM
Max Planck Institute of Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany.
Blüthgen
Nils
N
Fähling
Michael
M
Mrowka
Ralf
R
D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors
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