title: Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolines as antileishmanial agents.
abstract: A series of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline derivatives has been synthesized and evaluated for antileishmanial activity against Leishmania donovani. Compound 8 exhibited best antileishmanial activity with IC(50) value of 1.93 microg/ml against amastigotes, high selectivity index, and was more active than reference drugs sodium stilbogluconate and pentamidine.
authors.affiliation: Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Kumar
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Khan
authors.forename: Aditya
authors.initials: A
authors.lastname: Verma
authors.forename: Saumya
authors.initials: S
authors.lastname: Srivastava
authors.forename: Preeti
authors.initials: P
authors.lastname: Viswakarma
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Meena
authors.forename: Neetu
authors.initials: N
authors.lastname: Singh
authors.forename: Jayanta
authors.initials: J
authors.lastname: Sarkar
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007893:Leishmania donovani / Q000187:drug effects*; D051379:Mice
chemical_list: D000981:Antiprotozoal Agents; D002243:Carbolines