title: Use of morphometry to quantify osteolysis after total hip arthroplasty.
abstract: BACKGROUND
  Progressive osteolysis threatens the longevity of hip arthroplasties and radiographic review is recommended. Measurement of osteolytic lesions in a clinical setting has not been achieved easily in the past. Other radiologic investigations provide accurate information but cost and risk to the patient prohibit their use in routine review.
  
  
  OBJECTIVE
  We developed a simple, reliable tool to be used in hip arthroplasty review to quantify osteolytic changes seen on plain film radiographs.
  
  
  METHODS
  A morphometric grid was developed and tested on simulated and actual osteolytic lesions. Four health professionals measured lesions on each of two occasions. Intraclass correlation coefficients (ICC) for interobserver and intraobserver reliabilities were calculated and Bland-Altman plots were constructed for graphic analysis.
  
  
  RESULTS
  The ICCs for interobserver reliability on the simulated and actual osteolytic lesions were in the range 0.90 to 0.96. The values for intraobserver (test-retest) reliability were 0.97 to 0.98. The Bland-Altman plots confirmed agreement and in each case, proximity of the mean to zero indicated no significant bias.
  
  
  CONCLUSIONS
  The data show a morphometric grid is reliable for measuring osteolytic changes after hip arthroplasty.
  
  
  CONCLUSIONS
  This tool has potential to improve monitoring processes for hip arthroplasty and to be useful in future research studies. Additional work is needed to test for validity and clinical importance of the measurements obtained.
authors.affiliation: Department of Trauma and Orthopaedic Surgery, Weston General Hospital, Grange Road, Uphill, Weston-s-Mare, BS23 4TQ, England. smith@unforgettable.com
authors.forename: Lindsay K
authors.initials: LK
authors.lastname: Smith
authors.forename: Fiona
authors.initials: F
authors.lastname: Cramp
authors.forename: Shea
authors.initials: S
authors.lastname: Palmer
authors.forename: Nikki
authors.initials: N
authors.lastname: Coghill
authors.forename: Robert F
authors.initials: RF
authors.lastname: Spencer
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D003198:Computer Simulation; D004739:England; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D015588:Observer Variation; D010014:Osteolysis / Q000000981:diagnostic imaging* / Q000209:etiology; D011237:Predictive Value of Tests; D011859:Radiography; D015203:Reproducibility of Results; D016896:Treatment Outcome
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