Hippocampal volumes in adolescents with and without a family history of alcoholism.
OBJECTIVE
The hippocampus may be vulnerable to the effects of heavy alcohol use during adolescence, which is a time of continued neurodevelopment. However, differences in hippocampal volume may be due to risk factors such as a family history (FH) of alcoholism. We examined hippocampal volumes in youth with and without a FH of alcoholism prior to the initiation of alcohol use.


METHODS
Participants were demographically matched adolescents (aged 12-14) with positive (n = 15; FHP) and negative (n = 15; FHN) FH of alcoholism. Each group consisted of 10 males and 5 females with minimal previous substance use. Manual hippocampal tracings were completed on high-resolution magnetic resonance images by reliable raters, and intracranial volumes were controlled in analyses.


RESULTS
FH groups did not differ on memory or hippocampal volumes, but group x gender interactions (p < .05) indicated that FHP males had larger left hippocampi than FHN males. Females showed greater left versus right hippocampal asymmetry, while males showed larger right versus left asymmetry. For all adolescents, larger right hippocampal volumes predicted poorer delayed visual memory (p < .01).


CONCLUSIONS
Alcoholism risk factors, such as family history of alcoholism, may differentially influence adolescent hippocampal development for boys as compared to girls. Results suggest that FH does not account for prior findings of reduced left hippocampal volumes in heavy drinking youth. Findings are preliminary, but suggest that future studies examining the effects of alcohol use on the adolescent brain should consider the influence of FH, especially among boys.
Hanson
Karen L
KL
VA San Diego Healthcare System, Psychology Service, San Diego, California, USA. klhanson@ucsd.edu
Medina
Krista Lisdahl
KL
Nagel
Bonnie J
BJ
Spadoni
Andrea D
AD
Gorlick
Amanda
A
Tapert
Susan F
SF
D000293:Adolescent; D000437:Alcoholism / Q000150:complications*; D016022:Case-Control Studies; D002648:Child; D016241:Child of Impaired Parents; D005192:Family Health; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D009483:Neuropsychological Tests; D012307:Risk Factors; D012737:Sex Factors
Neuropsychologia. 2004;42(10):1394-413
15193947
JAMA. 1985 Nov 8;254(18):2614-7
4057470
Alcohol Clin Exp Res. 1995 Feb;19(1):110-22
7771636
Alcohol. 1997 Jan-Feb;14(1):31-7
9014021
J Stud Alcohol. 1998 Jul;59(4):427-38
9647425
Arch Gen Psychiatry. 1994 Jun;51(6):477-84
8192550
Psychiatry Res. 2005 Aug 30;139(3):181-90
16054344
Am J Psychiatry. 2000 May;157(5):737-44
10784466
Psychol Bull. 1994 Jan;115(1):55-73
8310100
Ann N Y Acad Sci. 2004 Jun;1021:77-85
15251877
Memory. 1999 Sep-Nov;7(5-6):715-32
10659094
Cereb Cortex. 2005 Feb;15(2):187-93
15238436
Behav Brain Res. 1999 Sep;103(2):123-33
10513581
Biol Psychiatry. 2001 Jun 1;49(11):894-905
11377407
J Comp Neurol. 1996 Mar 04;366(2):223-30
8698883
Neurotoxicol Teratol. 2007 Jan-Feb;29(1):141-52
17169528
J Int Neuropsychol Soc. 2002 Nov;8(7):873-83
12405538
Alcohol Clin Exp Res. 1995 Aug;19(4):1018-23
7485811
Cereb Cortex. 1996 Jul-Aug;6(4):551-60
8670681
Addiction. 2004 Nov;99 Suppl 2:5-22
15488102
Exp Neurol. 1983 Jul;81(1):1-13
6861939
Neuroimage. 2004 Jul;22(3):1060-75
15219578
J Abnorm Psychol. 1991 Nov;100(4):427-48
1757657