title: Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.
abstract: Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD.
authors.affiliation: Laboratory of Molecular Genetics, Department of Neurosciences B.B. Brodie, University of Cagliari, Cagliari, Italy. mirkomanchia@unica.it
authors.forename: Mirko
authors.initials: M
authors.lastname: Manchia
authors.forename: Clement C
authors.initials: CC
authors.lastname: Zai
authors.forename: Alessio
authors.initials: A
authors.lastname: Squassina
authors.forename: John B
authors.initials: JB
authors.lastname: Vincent
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Luca
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics; D012044:Regression Analysis; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins