title: Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium.
abstract: The association of invasive ovarian carcinoma risk with the functional polymorphism rs2228570 (aka rs10735810; FokI polymorphism) in the vitamin D receptor (VDR) gene was examined in 1820 white non-Hispanic cases and 3479 controls in a pooled analysis of five population-based case-control studies within the Ovarian Cancer Association Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Carriers of the rare T allele were at increased risk of ovarian carcinoma compared to women with the CC genotype in all studies combined; each copy of the T allele was associated with a modest 9% increased risk (OR = 1.09; 95% CI: 1.01-1.19; p = 0.04). No significant heterogeneity among studies was observed (p = 0.37) and, after excluding the dataset from the Hawaii study, the risk association for rs2228570 among replication studies was unchanged (OR = 1.09; 95% CI: 1.00-1.19; p = 0.06). A stronger association of rs2228570 with risk was observed among younger women (aged < 50 years versus 50 years or older) (p = 0.04). In all studies combined, the increased risk per copy of the T allele among younger women was 24% (OR = 1.24; 95% CI: 1.04-1.47; p = 0.02). This association remained statistically significant after excluding the Hawaii data (OR = 1.20; 95% CI: 1.01-1.43; p = 0.04). No heterogeneity of the association was observed by stage (p = 0.46), tumor histology (p = 0.98), or time between diagnosis and interview (p = 0.94). This pooled analysis provides further evidence that the VDR rs2228570 polymorphism might influence ovarian cancer susceptibility.
authors.affiliation: Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA. glurie@CRCH.hawaii.edu
authors.forename: Galina
authors.initials: G
authors.lastname: Lurie
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Thompson
authors.forename: Michael E
authors.initials: ME
authors.lastname: Carney
authors.forename: Rachel T
authors.initials: RT
authors.lastname: Palmieri
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Honglin
authors.initials: H
authors.lastname: Song
authors.forename: Estrid
authors.initials: E
authors.lastname: Hogdall
authors.forename: Susanne Kruger
authors.initials: SK
authors.lastname: Kjaer
authors.forename: Richard A
authors.initials: RA
authors.lastname: DiCioccio
authors.forename: Valerie
authors.initials: V
authors.lastname: McGuire
authors.forename: Alice S
authors.initials: AS
authors.lastname: Whittemore
authors.forename: Simon A
authors.initials: SA
authors.lastname: Gayther
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gentry-Maharaj
authors.forename: Usha
authors.initials: U
authors.lastname: Menon
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Ramus
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol
references.citation: Int J Epidemiol. 1994 Dec;23(6):1133-6
references.pmid: 7721513
references.citation: Gene. 2004 Sep 1;338(2):143-56
references.pmid: 15315818
references.citation: Am J Epidemiol. 2004 Oct 1;160(7):613-8
references.pmid: 15383404
references.citation: J Biol Chem. 2004 Dec 17;279(51):53213-21
references.pmid: 15485861
references.citation: Prog Biophys Mol Biol. 2006 Sep;92(1):49-59
references.pmid: 16566961
references.citation: Gynecol Oncol. 1992 Feb;44(2):131-6
references.pmid: 1312051
references.citation: Oncology. 2002;63(2):151-7
references.pmid: 12239450
references.citation: J Bone Miner Res. 1997 Jun;12(6):915-21
references.pmid: 9169350
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D533-6
references.pmid: 14681475
references.citation: Cancer Res. 2009 Mar 1;69(5):1885-91
references.pmid: 19223536
references.citation: Adv Exp Med Biol. 2008;622:53-67
references.pmid: 18546618
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):126-32
references.pmid: 15668485
references.citation: Mol Endocrinol. 2000 Mar;14(3):401-20
references.pmid: 10707958
references.citation: Int J Cancer. 2008 Jul 15;123(2):380-388
references.pmid: 18431743
references.citation: Am J Prev Med. 2006 Dec;31(6):512-4
references.pmid: 17169713
references.citation: Mol Cell Endocrinol. 2001 May 25;177(1-2):145-59
references.pmid: 11377830
references.citation: Anticancer Drugs. 1993 Apr;4(2):201-8
references.pmid: 8490200
references.citation: Clin Endocrinol (Oxf). 2000 Feb;52(2):211-6
references.pmid: 10671949
references.citation: Nat Rev Cancer. 2007 Sep;7(9):684-700
references.pmid: 17721433
references.citation: Anticancer Res. 2002 Jul-Aug;22(4):2261-7
references.pmid: 12174912
references.citation: J Nutr Biochem. 2007 Dec;18(12):771-7
references.pmid: 17531460
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2566-71
references.pmid: 18086759
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1160-6
references.pmid: 17548679
references.citation: Am J Epidemiol. 2004 Apr 15;159(8):750-8
references.pmid: 15051584
references.citation: J Mol Endocrinol. 2007 Jun;38(6):603-18
references.pmid: 17556531
references.citation: Gynecol Oncol. 2004 Dec;95(3):672-9
references.pmid: 15581980
references.citation: Cancer Lett. 2008 Feb 18;260(1-2):209-15
references.pmid: 18079052
references.citation: Carcinogenesis. 2006 Nov;27(11):2235-42
references.pmid: 16774946
references.citation: J Bone Miner Res. 1998 Nov;13(11):1691-9
references.pmid: 9797477
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1427-37
references.pmid: 16896028
references.citation: Int J Cancer. 2000 Apr 1;86(1):40-6
references.pmid: 10728592
references.citation: Am J Epidemiol. 2007 Apr 1;165(7):784-93
references.pmid: 17215380
references.citation: J Am Coll Nutr. 1999 Oct;18(5 Suppl):392S-397S
references.pmid: 10511319
references.citation: Cancer Prev Res (Phila). 2009 Jan;2(1):43-51
references.pmid: 19139017