title: Controlling the functional performance of emulsion-based delivery systems using multi-component biopolymer coatings.
abstract: The digestion and release of bioactive lipophilic components encapsulated within emulsion-based delivery systems can be controlled by coating the lipid droplets with biopolymer coatings. In this study, multi-component biopolymer coatings were formed around lipid droplets using an interfacial electrostatic deposition approach. These coatings consisted of an inner layer of globular protein (beta-lactoglobulin), an intermediate layer of cationic polysaccharide (chitosan), and an outer layer of anionic polysaccharide (pectin or alginate). In the absence of the outer anionic polysaccharide layer, the protein-chitosan-coated droplets were highly unstable to aggregation at high pH values (pH>6), due to loss of chitosan charge. In the presence of the outer layer, the droplets had good stability to aggregation from pH 7 to 4, but aggregated at lower pH due to loss of pectin or alginate charge. An in vitro lipid digestion model (pH stat) indicated that polysaccharide coatings reduced the rate of lipid digestibility. These findings have important implications for the design of delivery systems for bioactive lipophilic components in the pharmaceutical, biopharmaceutical, and food industries.
authors.affiliation: Department of Environmental Science, Wuhan University, Wuhan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Hang
authors.initials: H
authors.lastname: Xiao
authors.forename: Yumin
authors.initials: Y
authors.lastname: Du
authors.forename: Eric Andrew
authors.initials: EA
authors.lastname: Decker
authors.forename: David Julian
authors.initials: DJ
authors.lastname: McClements
mesh_terms: D000464:Alginates / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004339:Drug Compounding; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry*; D008066:Lipolysis; D008956:Models, Chemical; D010368:Pectins / Q000737:chemistry; D055672:Static Electricity; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000464:Alginates; D001704:Biopolymers; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D010368:Pectins; D048271:Chitosan