Eukaryotic translation initiation factor 1 (eIF1), the inspector of good AUG context for translation initiation, has an extremely bad AUG context.
The nucleotide sequence surrounding the translation initiation AUG codon (AUG context) is important for the effective translation initiation. A compilation analysis revealed that all the genes of the eukaryotic translation initiation factor 1, which plays a crucial role in the recognition of the optimal AUG context, ironically have extremely bad AUG contexts.
Miyasaka
Hitoshi
H
The Kansai Electric Power Co., Environmental Research Center, Keihanna-Plaza 12F, 1-7 Seikacho, Sourakugun, Kyoto 619-0237, Japan. miyasaka.hitoshi@a4.kepco.co.jp
Endo
Sumiyo
S
Shimizu
Hiroyuki
H
D000818:Animals; D001483:Base Sequence; D018387:Codon, Initiator; D039642:Eukaryotic Initiation Factors / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000737:chemistry
D018387:Codon, Initiator; C410108:EIF1 protein, human; D039642:Eukaryotic Initiation Factors; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger