Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approach.
The inaccuracy of the early diagnosis of Parkinson's disease (PD) has been a major incentive for studies aimed at the identification of biomarkers. Brain-derived cerebrospinal fluid (CSF) proteins are potential biomarkers considering the major role that proteins play in PD pathogenesis. In this review, we discuss the current hypotheses about the pathogenesis of PD and identify the most promising candidate biomarkers among the CSF proteins studied so far. The list of potential markers includes proteins involved in various pathogenetic processes, such as oxidative stress and protein aggregation. This list will undoubtedly grow in the near future by application of CSF proteomics and subsequent validation of identified proteins. Probably a single biomarker will not suffice to reach high sensitivity and specificity, because PD is pathogenetically heterogeneous and shares etiological factors with other neurodegenerative diseases. Furthermore, identified candidate biomarkers will have to be thoroughly validated before they can be implemented as diagnostic aids.
van Dijk
Karin D
KD
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, The Netherlands. Karin.vanDijk@vumc.nl
Teunissen
Charlotte E
CE
Drukarch
Benjamin
B
Jimenez
Connie R
CR
Groenewegen
Henk J
HJ
Berendse
Henk W
HW
van de Berg
Wilma D J
WD
D015415:Biomarkers / Q000134:cerebrospinal fluid*; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid*; D006801:Humans; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D040901:Proteomics
D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins
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