title: [Study on solubility of Chinese herbal compound by solubility parameter].
abstract: OBJECTIVE
  To demonstrate the solubility of Chinese herbal compound with solubility parameters.
  
  
  METHODS
  The solubility parameters of Liangfu effective components and Liangfu compound were determined by inverse gas chromatograph (IGC) and group contribution. Hansen ball was plotting by HSPiP, which could be used to investigate the solubility of Liangfu effective components and Liangfu compound in different solvents. And the results were verified by approximate solubility.
  
  
  RESULTS
  Liangfu effective components and Liangfu compound could be dissolved in chloroform, ethyl acetate, acetone, octanol and ether, and were slightly soluble in glycerol, methanol, ethanol and propanediol, but could not be dissolved in water. They were all liposoluble, and the results were the same as the test results of the approximate solubility.
  
  
  CONCLUSIONS
  The solubility of Chinese herbal compound can be expressed by solubility parameters, and it is accurate, convenient and visual.
authors.affiliation: Key Laboratory for Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. wudez@tom.com
authors.forename: Dezhi
authors.initials: D
authors.lastname: Wu
authors.forename: Lihua
authors.initials: L
authors.lastname: Chen
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.forename: Weifeng
authors.initials: W
authors.lastname: Zhu
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Guan
mesh_terms: D002849:Chromatography, Gas / Q000295:instrumentation; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D012997:Solvents