Prenatal sonographic features of fetuses in trisomy 13 pregnancies. IV.
Prenatal ultrasound is a powerful tool to detect structural abnormalities associated with the fetuses in trisomy 13 pregnancies. This article provides a comprehensive review of the prenatal sonographic markers of trisomy 13 in the first trimester, including fetal nuchal translucency thickness, fetal heart rate, fetal nasal bone, fetal tricuspid regurgitation, ductus venous flow, fetal crown-rump length, fetal trunk and head volume, fetal frontomaxillary facial angle, gestational sac volume and umbilical cord diameter, along with biochemical markers such as maternal serum free beta-human chorionic gonadotropin, maternal serum pregnancy-associated plasma protein-A, maternal serum placental growth factor, and the fetal and total cell-free DNA concentration in the maternal circulation.
Chen
Chih-Ping
CP
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. cpc_mmh@yahoo.com
D000782:Aneuploidy; D002508:Cephalometry; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D002882:Chromosomes, Human, Pair 13; D018568:Crown-Rump Length; D004247:DNA / Q000097:blood; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging; D005145:Face / Q000000981:diagnostic imaging / Q000196:embryology; D005146:Facial Asymmetry / Q000000981:diagnostic imaging; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging; D006340:Heart Rate, Fetal; D006801:Humans; D008423:Maternal Age; D008437:Maxilla / Q000000981:diagnostic imaging / Q000196:embryology; D009295:Nasal Bone / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000196:embryology; D048208:Nuchal Translucency Measurement; D000072483:Placenta Growth Factor; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging; D014314:Trisomy / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal; D014470:Umbilical Cord / Q000000981:diagnostic imaging
D018997:Chorionic Gonadotropin, beta Subunit, Human; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D004247:DNA; D011266:Pregnancy-Associated Plasma Protein-A