[Study on solubility of Chinese herbal compound by solubility parameter].
OBJECTIVE
To demonstrate the solubility of Chinese herbal compound with solubility parameters.


METHODS
The solubility parameters of Liangfu effective components and Liangfu compound were determined by inverse gas chromatograph (IGC) and group contribution. Hansen ball was plotting by HSPiP, which could be used to investigate the solubility of Liangfu effective components and Liangfu compound in different solvents. And the results were verified by approximate solubility.


RESULTS
Liangfu effective components and Liangfu compound could be dissolved in chloroform, ethyl acetate, acetone, octanol and ether, and were slightly soluble in glycerol, methanol, ethanol and propanediol, but could not be dissolved in water. They were all liposoluble, and the results were the same as the test results of the approximate solubility.


CONCLUSIONS
The solubility of Chinese herbal compound can be expressed by solubility parameters, and it is accurate, convenient and visual.
Wu
Dezhi
D
Key Laboratory for Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. wudez@tom.com
Chen
Lihua
L
Wang
Sen
S
Zhu
Weifeng
W
Guan
Yongmei
Y
D002849:Chromatography, Gas / Q000295:instrumentation; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D012997:Solvents