title: [Meta-analysis of clinical randomized controlled trials on aspherical intraocular lens].
abstract: OBJECTIVE
  To evaluate the effects of aspherical intraocular lens (IOL) on the wavefront aberration by using meta analysis.
  
  
  METHODS
  Trials were identified by searching the following electronic database for clinical randomized controlled trials about aspherical IOL and wavefront aberration: Medline, Chinese Medical Current Contents (CMCC), China National Knowledge Infrastructure (CNKI). Data were combined for meta-analysis using weighted mean difference (WMD) for discontinuous data.
  
  
  RESULTS
  Fifteen clinical randomized controlled trials with 436 eyes were included in the aspherical IOL group and 452 eyes in the spherical IOL group. The total Z(4)(0), internal Z(4)(0), total aberration, high-order aberrations (HOA) and the internal coma in the aspherical IOL group were lower than those of the conventional spherical IOL group. There was significant difference between these two groups (P < 0.05). The WMD and 95% confidence internals (CI) were -0.12 (-0.13 to -0.11); -0.08 (-0.09 to -0.07); -0.07 (-0.10 to -0.04); -0.56 (-0.73 to -0.39) and -0.06 (-0.10 to -0.01), respectively. There were no significant difference of the best spectacle-corrected visual acuity (BSCVA), total coma and total trefoil between these two groups (P > 0.05). The WMD and 95%CI were 0.12 (-0.06 to -0.29); 0.02 (-0.01 to 0.04) and 0.00 (-0.04 to 0.05), respectively.
  
  
  CONCLUSIONS
  Aspherical IOL can reduce spherical aberration. The changes of coma and the changes of the aberration induced by the cornea incision need further exploration.
authors.affiliation: Tianjin Eye Hospital, Tianjin 300020, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Tang
mesh_terms: D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D016032:Randomized Controlled Trials as Topic