Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment.
BACKGROUND
Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented.


RESULTS
The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA.


CONCLUSIONS
PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.
Teramoto
Tomohiko
T
Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Ikeno
Fumiaki
F
Otake
Hiromasa
H
Lyons
Jennifer K
JK
van Beusekom
Heleen M M
HM
Fearon
William F
WF
Yeung
Alan C
AC
D000818:Animals; D049109:Cell Proliferation; D003331:Coronary Vessels / Q000473:pathology* / Q000601:surgery; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005337:Fibrin / Q000032:analysis; D008670:Metals; D011509:Proteoglycans / Q000032:analysis; D015607:Stents / Q000009:adverse effects*; D013552:Swine; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology*
D008670:Metals; D011509:Proteoglycans; D005337:Fibrin