title: The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.
abstract: Two new metabolites, 3R,5R-Sonnerlactone (1) and 3R,5S-Sonnerlactone (2), were isolated from the mangrove endophytic fungus Zh6-B1 obtained from the South China Sea. Their structures were elucidated by MS and NMR. The absolute configuration of compound 1 was determined by single-crystal X-ray analysis using Cu Kalpha radiation. The absolute configuration of compound 2 was determined by NOESY analysis and comparing circular dichroism spectroscopy with compound 1. The antiproliferative activity of compound 1 and 2 against the multi-drug resistant human oral floor carcinoma cells (KV) was evaluated.
authors.affiliation: School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
authors.forename: Kai-Kai
authors.initials: KK
authors.lastname: Li
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Lu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Song
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Xi-Wei
authors.initials: XW
authors.lastname: Wu
authors.forename: Lin-Kun
authors.initials: LK
authors.lastname: An
authors.forename: Chuang-Xing
authors.initials: CX
authors.lastname: Ye
authors.forename: Yong-Cheng
authors.initials: YC
authors.lastname: Lin
mesh_terms: D045744:Cell Line, Tumor; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D029561:Lythraceae / Q000737:chemistry* / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D012623:Seawater; D021241:Spectrometry, Mass, Electrospray Ionization