Glaucomatous progression in series of stereoscopic photographs and Heidelberg retina tomograph images.
OBJECTIVE
To compare optic disc changes using automated analysis of Heidelberg retina tomograph (HRT) images with assessments, by glaucoma specialists, of change in stereoscopic photographs.


METHODS
Baseline and follow-up stereophotographs and corresponding HRT I series of 91 eyes from 56 patients were selected. The selection criteria were sufficiently long, good-quality HRT series (7 visits in > or =70 months of follow-up) and follow-up photographs contemporaneous with the final HRT image. Topographic change analysis (TCA), statistic image mapping (SIM), and linear regression of rim area (RALR) across time were applied to HRT series. Glaucomatous change determined from stereophotographs by expert observers was used as the reference standard.


RESULTS
Expert observers identified 33 eyes (36%) as exhibiting glaucomatous change. Altering HRT progression criteria such that 36% of eyes progressed according to each method resulted in concordance between HRT methods and stereophotograph assessment of 54% for TCA, 65% for SIM, and 67% for RALR (Cohen kappa = 0.05, 0.23, and 0.30, respectively). Receiver operating characteristic curves of the HRT analyses revealed poor precision of HRT analyses to predict stereophotograph-assessed change: areas under the curve were 0.61 for TCA, 0.62 for SIM, and 0.66 for RALR.


CONCLUSIONS
Statistical methods for detecting structural changes in HRT images exhibit only moderate agreement with each other and have poor agreement with expert-assessed change in optic disc stereophotographs.
O'Leary
Neil
N
Department of Optometry and Visual Science, City University London, Northampton Square, London EC1V 0HB, United Kingdom. oleary.neil@gmail.com
Crabb
David P
DP
Mansberger
Steven L
SL
Fortune
Brad
B
Twa
Michael D
MD
Lloyd
Michael J
MJ
Kotecha
Aachal
A
Garway-Heath
David F
DF
Cioffi
George A
GA
Johnson
Chris A
CA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000503:physiopathology; D010781:Photography; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014054:Tomography; D014792:Visual Acuity
Ophthalmology. 1992 Jan;99(1):29-35
1741134
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2621-6
12766065
Am J Ophthalmol. 1991 Feb 15;111(2):221-9
1992744
Radiology. 1983 Sep;148(3):839-43
6878708
Am J Ophthalmol. 2009 Jan;147(1):39-44.e1
18790472
Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1173-80
17325161
Curr Opin Ophthalmol. 2004 Apr;15(2):96-101
15021219
Br J Ophthalmol. 2005 Nov;89(11):1427-32
16234446
Prog Retin Eye Res. 2005 May;24(3):333-54
15708832
Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4881-5
18689707
Br J Ophthalmol. 1997 Oct;81(10):840-5
9486023
Ophthalmology. 2009 Nov;116(11):2110-8
19500850
Br J Ophthalmol. 2003 Jun;87(6):726-30
12770970
Graefes Arch Clin Exp Ophthalmol. 2006 Apr;244(4):460-4
16133021
Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1730-42
10845593
Am J Ophthalmol. 1985 Jan 15;99(1):1-4
3966515
Ophthalmology. 2000 Dec;107(12):2272-7
11097609
Acta Ophthalmol. 2008 Mar;86(2):207-14
17986295
Invest Ophthalmol Vis Sci. 2000 Mar;41(3):775-82
10711693
Invest Ophthalmol Vis Sci. 2002 Jan;43(1):140-5
11773024
Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2660-5
12147600
Br J Ophthalmol. 2005 Jul;89(7):879-84
15965171
Br J Ophthalmol. 2003 May;87(5):557-9
12714391
Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5348-55
17122123
Invest Ophthalmol Vis Sci. 2005 May;46(5):1659-67
15851566
J Glaucoma. 1995 Aug;4(4):242-7
19920681
Ophthalmology. 1993 Jan;100(1):57-62
8433828
Ophthalmology. 1998 Aug;105(8):1557-63
9709774
Invest Ophthalmol Vis Sci. 2004 May;45(5):1396-403
15111594
Ophthalmology. 2007 Nov;114(11):1973-80
17662455
Br J Ophthalmol. 2005 Nov;89(11):1433-7
16234447
Br J Ophthalmol. 2007 May;91(5):624-8
17050585
Arch Ophthalmol. 2001 Oct;119(10):1492-9
11594950
Ophthalmology. 2002 Mar;109(3):467-81
11874747
J Glaucoma. 1996 Apr;5(2):79-90
8795739
Br J Ophthalmol. 2007 Mar;91(3):313-8
17035283
Can J Ophthalmol. 2007 Feb;42(1):82-8
17361246
Arch Ophthalmol. 1992 Feb;110(2):206-10
1736869
Ophthalmology. 2003 Feb;110(2):340-4
12578778
J Glaucoma. 1998 Apr;7(2):121-7
9559499
Ophthalmology. 2002 Jun;109(6):1072-7
12045046
Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1682-91
19060290
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2512-7
18326698
Graefes Arch Clin Exp Ophthalmol. 2000 May;238(5):375-84
10901468
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2904-10
16799032
Am J Ophthalmol. 1994 Jul 15;118(1):9-15
8023882
Graefes Arch Clin Exp Ophthalmol. 1991;229(2):133-8
2044972
Am J Ophthalmol. 2005 Oct;140(4):762-4
16226544
Br J Ophthalmol. 1999 Mar;83(3):290-4
10365035
Arch Ophthalmol. 2001 Jul;119(7):985-93
11448320