Herpes viruses in transplant recipients: HSV, VZV, human herpes viruses, and EBV.
The herpes viruses are responsible for a wide range of diseases in patients following transplant, resulting from direct viral effects and indirect effects, including tumor promotion. Effective treatments and prophylaxis exist for the neurotropic herpes viruses HSV-1, HSV-2, varicella zoster virus, and possibly HHV-6. Antivirals seem to be less effective at prevention of the tumor-promoting effects of Epstein-Barr virus and HHV-8. Reduction in immunosuppression is the cornerstone to treatment of many diseases associated with herpes virus infections.
Shiley
Kevin
K
Division of Infectious Diseases, Hospital of the University of Pennsylvania, 3rd Floor Silverstein Pavilion, Suite E, 3400 Spruce Street, Philadelphia, PA 19104, USA. shileyk@uphs.upenn.edu
Blumberg
Emily
E
D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000302:isolation & purification; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D016199:Herpesvirus 7, Human / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D014180:Transplantation
D007166:Immunosuppressive Agents