title: 5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder.
abstract: Disturbances in the expression/function of the 5-HT2A receptor are implicated in autism. The association of the 5-HT2A receptor gene with autism was studied in the Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism.
authors.affiliation: Department of Animal Physiology, Faculty of Science, University of Zagreb, and Psychiatric Hospital for Children and Youth, Zagreb, Croatia. dubravka@zg.biol.pmf.hr
authors.forename: Dubravka
authors.initials: D
authors.lastname: Hranilovic
authors.forename: Sofia
authors.initials: S
authors.lastname: Blazevic
authors.forename: Marina
authors.initials: M
authors.lastname: Babic
authors.forename: Maja
authors.initials: M
authors.lastname: Smurinic
authors.forename: Zorana
authors.initials: Z
authors.lastname: Bujas-Petkovic
authors.forename: Branimir
authors.initials: B
authors.lastname: Jernej
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D017523:Croatia / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A