title: Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects.
abstract: Pathological gambling (PG) is an impulse control disorder with suggestive genetic vulnerability component. We evaluated the association of genetic variants in the dopaminergic receptor genes (DRD1-3s) with risk for gambling in healthy subjects using the Canadian Problem Gambling Index (CPGI). Healthy Caucasian subjects who had gambled at least once in their lifetime (n=242) were included in the analysis. Gender was not associated with the CPGI, while younger age was associated with higher CPGI scores. We have found that none of the single polymorphisms investigated on DRD1 and DRD3 were associated with CPGI scores in healthy subjects. However, we observed trends for association on the TaqIA/rs1800497 polymorphism (P=0.10) and the haplotype flanking DRD2 (G/C/A rs11604671/rs4938015/rs2303380; P=0.06). Both trends were associated with lower CPGI score. Our results provide further evidence for the role of dopamine D2-like receptor in addiction susceptibility.
authors.affiliation: Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. daniela_lobo@camh.net
authors.forename: Daniela S S
authors.initials: DS
authors.lastname: Lobo
authors.forename: Renan P
authors.initials: RP
authors.lastname: Souza
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Tong
authors.forename: David M
authors.initials: DM
authors.lastname: Casey
authors.forename: David C
authors.initials: DC
authors.lastname: Hodgins
authors.forename: Garry J
authors.initials: GJ
authors.lastname: Smith
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Williams
authors.forename: Don P
authors.initials: DP
authors.lastname: Schopflocher
authors.forename: Rob T
authors.initials: RT
authors.lastname: Wood
authors.forename: Nady
authors.initials: N
authors.lastname: el-Guebaly
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D002170:Canada; D016009:Chi-Square Distribution; D002880:Chromosomes, Human, Pair 11; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000235:genetics*; D005260:Female; D005715:Gambling / Q000523:psychology*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics*