Role of D-dimer testing in severe pelvic inflammatory disease: a new usable marker to assess the need for fertility-impairing surgery?
Pelvic inflammatory disease (PID), like many other inflammatory diseases, can be characterized by an inflammation-induced activation of the coagulation cascade, resulting in the production of D-dimers. In this study it is demonstrated how high levels of D-dimers, assayed at the time of hospitalization, are encountered in patients diagnosed with PID and how the levels of this parameter are significantly higher in patients, which due to the severity of the disease, needed surgical treatment. Therefore the d-dimer is shown to be an important parameter to be considered in the therapeutic counseling of severe forms of PID.
Franchi
Laura
L
Department of Maternal and Child Health, OB/GYN Unit, University of Parma, Parma, Italy.
Patrelli
Tito Silvio
TS
Berretta
Roberto
R
Rolla
Martino
M
Gizzo
Salvatore
S
Gramellini
Dandolo
D
Bacchi Modena
Alberto
A
Nardelli
Giovanni Battista
GB
D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D005260:Female; D005298:Fertility / Q000502:physiology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis* / Q000502:physiology; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D008403:Mass Screening / Q000379:methods; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D