title: Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis.
abstract: In this open-label, randomized, multiple-dose, two-treatment crossover study, 24 postmenopausal women with moderate to severe atrophic vaginitis received 0.3 mg conjugated estrogens daily for 14 days: 7 days orally (0.3 mg tablet) and 7 days vaginally (0.5 g cream). Steady-state plasma concentrations of E2 and estrone were one-third lower after vaginal versus oral administration of conjugated estrogens.
authors.affiliation: Pfizer, Collegeville, Pennsylvania 19426, USA. marybethdorr@yahoo.com
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Dorr
authors.forename: Anita L
authors.initials: AL
authors.lastname: Nelson
authors.forename: Philip R
authors.initials: PR
authors.lastname: Mayer
authors.forename: Radhika P
authors.initials: RP
authors.lastname: Ranganath
authors.forename: Paul M
authors.initials: PM
authors.lastname: Norris
authors.forename: Eileen C
authors.initials: EC
authors.lastname: Helzner
authors.forename: Richard A
authors.initials: RA
authors.lastname: Preston
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000368:Aged; D001284:Atrophy / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood*; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D004970:Estrone / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D009994:Osmolar Concentration; D014621:Vagina / Q000187:drug effects / Q000473:pathology*; D014622:Vaginal Creams, Foams, and Jellies; D014627:Vaginitis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004966:Estrogens, Conjugated (USP); D014622:Vaginal Creams, Foams, and Jellies; D004970:Estrone; D004958:Estradiol