title: Radiotherapy of large target volumes in Hodgkin's lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques.
abstract: BACKGROUND
  This paper analyses normal tissue sparing capability of radiation treatment techniques in Hodgkin's lymphoma with large treatment volume.
  
  
  METHODS
  10 patients with supradiaphragmatic Hodgkin's lymphoma and planning target volume (PTV) larger than 900 cm3 were evaluated. Two plans were simulated for each patient using 6 MV X-rays: a conventional multi-leaf (MLC) parallel-opposed (AP-PA) plan, and the same plan with additional MLC shaped segments (forward planned intensity modulated radiation therapy, FPIMRT). In order to compare plans, dose-volume histograms (DVHs) of PTV, lungs, heart, spinal cord, breast, and thyroid were analyzed. The Inhomogeneity Coefficient (IC), the PTV receiving 95% of the prescription dose (V95), the normal tissue complication probability (NTCP) and dose-volume parameters for the OARs were determined.
  
  
  RESULTS
  the PTV coverage was improved (mean V95AP-PA=95.9 and ICAP-PA=0.4 vs. V95FPIMRT=96.8 and ICFPIMRT=0.31, p<or=0.05) by the FPIMRT technique compared to the conventional one. At the same time, NTCPs of lung, spinal cord and thyroid, and the volume of lung and thyroid receiving>or=30 Gy resulted significantly reduced when using the FPIMRT technique.
  
  
  CONCLUSIONS
  The FPIMRT technique can represent a very useful and, at the same time, simple method for improving PTV conformity while saving critical organs when large fields are needed as in Hodgkin's lymphoma.
authors.affiliation: Institute of Biostructures and Bioimages, National Council of Research (CNR), Via Pansini 5, 80131, Naples, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Cella
authors.forename: Raffaele
authors.initials: R
authors.lastname: Liuzzi
authors.forename: Mario
authors.initials: M
authors.lastname: Magliulo
authors.forename: Manuel
authors.initials: M
authors.lastname: Conson
authors.forename: Luigi
authors.initials: L
authors.lastname: Camera
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.forename: Roberto
authors.initials: R
authors.lastname: Pacelli
mesh_terms: D000328:Adult; D001940:Breast / Q000528:radiation effects*; D005260:Female; D006321:Heart / Q000528:radiation effects*; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008168:Lung / Q000528:radiation effects*; D008297:Male; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D013116:Spinal Cord / Q000528:radiation effects*; D013961:Thyroid Gland / Q000528:radiation effects*; D055815:Young Adult
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