Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea.
Several recent discoveries reveal unexpected versatility of the bacterial and archaeal cytoskeleton systems that are involved in cell division and other processes based on membrane remodeling. Here we apply methods for distant protein sequence similarity detection, phylogenetic approaches, and genome context analysis to described two previously unnoticed families of the FtsZ-tubulin superfamily. One of these families is limited in its spread to Proteobacteria whereas the other is represented in diverse bacteria and archaea, and might be the key component of a novel, multicomponent membrane remodeling system that also includes a Von Willebrand A domain-containing protein, a distinct GTPase and membrane transport proteins of the OmpA family.
Makarova
Kira S
KS
National Center for Biotechnology Information, NLM, National Institutes of Health Bethesda, Maryland 20894, USA.
Koonin
Eugene V
EV
D001105:Archaea / Q000378:metabolism*; D019843:Archaeal Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D002462:Cell Membrane / Q000145:classification / Q000378:metabolism*; D010802:Phylogeny; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
D019843:Archaeal Proteins; D001426:Bacterial Proteins; D014404:Tubulin
Extremophiles. 2009 Jan;13(1):67-79
18972064
J Mol Biol. 2000 Jul 21;300(4):805-18
10891270
Int J Biochem Cell Biol. 2009 Feb;41(2):323-9
18768164
Methods Enzymol. 1996;266:418-27
8743697
Proc Int Conf Intell Syst Mol Biol. 1998;6:175-82
9783223
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18942-6
18987308
Mol Biol Cell. 2002 Oct;13(10):3369-87
12388743
Nucleic Acids Res. 2002 Jan 1;30(1):281-3
11752315
Mol Biol Evol. 2007 Jul;24(7):1439-42
17412703
Annu Rev Biophys Biomol Struct. 2004;33:177-98
15139810
Curr Opin Struct Biol. 2006 Apr;16(2):221-9
16549346
Res Microbiol. 2008 Jun;159(5):390-9
18625304
Nat Struct Biol. 1998 Jun;5(6):451-8
9628483
EMBO Rep. 2004 Jun;5(6):567-71
15170475
Annu Rev Plant Biol. 2002;53:503-21
12221987
Genes Dev. 2009 May 1;23(9):1131-44
19417107
Nucleic Acids Res. 2008 Apr;36(7):2295-300
18287115
Science. 2006 Jan 13;311(5758):242-5
16373532
J Mol Evol. 2004 Jan;58(1):19-29
14743312
J Mol Biol. 2002 Mar 15;317(1):41-72
11916378
Nat Protoc. 2007;2(4):953-71
17446895
Nucleic Acids Res. 2007 Jan;35(Database issue):D61-5
17130148
J Bacteriol. 2000 May;182(10):2985-8
10781574
Science. 2008 Dec 12;322(5908):1710-3
19008417
Bioinformatics. 2000 Apr;16(4):404-5
10869041
J Mol Biol. 2001 Nov 9;313(5):1045-57
11700061
Microbiol Mol Biol Rev. 2006 Sep;70(3):729-54
16959967
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8
15980461
Biol Direct. 2009 Feb 26;4:9
19245710
Chem Phys Lipids. 2006 Jun;141(1-2):30-47
16581049
Trends Biochem Sci. 1998 Nov;23(11):444-7
9852764
J Bacteriol. 2006 Apr;188(8):2829-35
16585744
Genes Dev. 2007 Jun 1;21(11):1340-52
17510284
Trends Microbiol. 2009 Nov;17(11):507-13
19783442
Bioinformatics. 2002 Apr;18(4):617-25
12016059
Nucleic Acids Res. 2010 Jun;38(11):3743-59
20156992
Biochim Biophys Acta. 2008 Sep;1778(9):1871-80
17601489
J Mol Biol. 2007 Nov 9;373(5):1229-42
17900614
Nature. 2001 Sep 6;413(6851):39-44
11544518
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
9254694
FEMS Microbiol Lett. 2007 Aug;273(1):1-11
17559395
Annu Rev Biochem. 2000;69:277-302
10966460
Commun Integr Biol. 2009;2(2):86-8
19704896