Simian recombinant adenovirus delivered by the mucosal route modulates gammadelta T cells from murine genital tract.
Although it has been demonstrated that mucosal immunization using vectors such as simian adenovirus (AdC) stimulates robust adaptive immune responses, there remains a paucity of information on the modulation of innate immune responses by such vectors. Using an established murine model of intravaginal immunization (Ivag), we have investigated whether mucosal gammadelta T cells participate in immune responses induced by AdC vectors. gammadelta T cell numbers were found to be increased in the vaginal tract. Moreover, gammadelta T cells isolated from the genital tract showed an activated phenotype and enhanced expression of cytokine gene. Altogether, our results demonstrate that AdC modulates gammadelta T cell responses and suggest that this cell population may influence immune responses following vaginal immunization.
Lanza
Silvia R
SR
Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil.
Menin
Alvaro
A
Ertl
Hildegund C J
HC
Báfica
André
A
Pinto
Aguinaldo R
AR
D000261:Adenoviruses, Simian / Q000276:immunology*; D000282:Administration, Intravaginal; D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D018928:Immunity, Mucosal; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014621:Vagina / Q000276:immunology*