General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates.
A wide range of 2-pyridyl and other difficult-to-access heterocyclic N-methyliminodiacetic acid boronates can be readily prepared from the corresponding bromides via a new method involving direct transligation of 2-heterocyclic trialkoxyborate salts with N-methyliminodiacetic acid (MIDA) at elevated temperatures.
Dick
Graham R
GR
Howard Hughes Medical Institute, Roger Adams Lab, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Knapp
David M
DM
Gillis
Eric P
EP
Burke
Martin D
MD
D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007098:Imino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D001897:Boronic Acids; D006571:Heterocyclic Compounds; D007098:Imino Acids; C533766:N-methyliminodiacetic acid
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