title: Combined InCl3- and amine-catalyzed intramolecular addition of alpha-disubstituted aldehydes onto unactivated alkynes.
abstract: The combination of enamine-type catalysis to the indium-catalyzed activation of alkynes allows the efficient preparation of functionalized cyclopentanes bearing a quaternary stereogenic center. A broad range of formylalkynyl derivatives has been prepared. The InCl(3)/(Cy)(i-Pr)NH system efficiently promotes the carbocyclization reaction of alpha-disubstituted aldehydes in good to excellent yields.
authors.affiliation: ENSCP, Chimie ParisTech, UMR 7223, Laboratoire Charles Friedel, 11 rue P. et M. Curie, 75231 Paris Cedex 05, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Montaignac
authors.forename: Maxime R
authors.initials: MR
authors.lastname: Vitale
authors.forename: Veronique
authors.initials: V
authors.lastname: Michelet
authors.forename: Virginie
authors.initials: V
authors.lastname: Ratovelomanana-Vidal