Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder.
OBJECTIVE
Patients with idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) may show electroencephalographic (EEG) slowing reflecting cortical dysfunction and are at risk for developing neurological conditions characterized by cognitive dysfunction including mild cognitive impairment (MCI), dementia with Lewy bodies and Parkinson's disease with associated dementia. We hypothesized that those IRBD patients who later developed MCI had pronounced cortical EEG slowing at presentation.


METHODS
Power EEG spectral analysis was blindly quantified from the polysomnographic studies of 23 IRBD patients without cognitive complaints and 10 healthy controls without RBD. After a mean clinical follow-up of 2.40+/-1.55 years, 10 patients developed MCI (RBD+MCI) and the remaining 13 remained idiopathic.


RESULTS
Patients with RBD+MCI had marked EEG slowing (increased delta and theta activity) in central and occipital regions during wakefulness and REM sleep, particularly in the right hemisphere, when compared with controls and, to a lesser extent, with IRBD subjects who remained idiopathic. The EEG spectral pattern of the RBD+MCI group was similar to that seen in patients with dementia with Lewy bodies and Parkinson's disease associated with dementia.


CONCLUSIONS
Our findings suggest that the presence of marked EEG slowing on spectral analysis might be indicative of the short-term development of MCI in patients initially diagnosed with IRBD.
Iranzo
Alex
A
Neurology Service, Multidisciplinary Sleep Unit, Hospital Clínic de Barcelona, Institut D'Investigació Biomèdiques August Pi i Sunyer, CIBERNED, Barcelona, Spain.
Isetta
Valentina
V
Molinuevo
Jose Luis
JL
Serradell
Monica
M
Navajas
Daniel
D
Farre
Ramon
R
Santamaria
Joan
J
D000368:Aged; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D003700:Delta Rhythm; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017286:Polysomnography; D011594:Psychometrics; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D012895:Sleep, REM / Q000502:physiology; D013826:Theta Rhythm