The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats.
Individuals with epilepsy often complain about memory deficits. Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages. The aim of the present study was to investigate the effects of rutin on memory retrieval in pentylenetetrazole (PTZ)-kindled rats using a step-through passive avoidance task. We administered rutin and PTZ intraperitoneally every other day prior to the start of training. Two retention tests were subsequently performed to assess memory in these rats. The results suggest that pretreatment with rutin at 50 and 100mg/kg can attenuate seizure severity during the kindling procedure. Furthermore, rutin administration significantly increased the step-through latency in the passive avoidance paradigm. Taken together, these results indicate that rutin has a potential role in enhancing memory retrieval in kindled rats.
Nassiri-Asl
Marjan
M
Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Iran. marjannassiriaslm@gmail.com
Mortazavi
Seyed-Reza
SR
Samiee-Rad
Fatemeh
F
Zangivand
Amir-Abdollah
AA
Safdari
Freshteh
F
Saroukhani
Sepideh
S
Abbasi
Esmail
E
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012153:Retention, Psychology / Q000187:drug effects*; D012431:Rutin / Q000008:administration & dosage / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy*
D012431:Rutin; D010433:Pentylenetetrazole