Enzymatic preparation of arbutin derivatives: lipase-catalyzed direct acylation without the need of vinyl ester as an acyl donor.
Direct and regioselective acylation of arbutin with aromatic or aliphatic acid using a lipase obtained from Candida antarctica in an organic solvent was investigated. We achieved the enzymatic synthesis of feruloyl arbutin and lipoyl arbutin without the need of vinyl ferulate and vinyl lipoate as acyl donors, respectively.
Ishihara
Kohji
K
Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan. ishihara@dls.ous.ac.jp
Katsube
Yasuko
Y
Kumazawa
Nozomi
N
Kuratani
Mari
M
Masuoka
Noriyoshi
N
Nakajima
Nobuyoshi
N
D000215:Acylation; D001104:Arbutin / Q000031:analogs & derivatives*; D002175:Candida / Q000201:enzymology; D002384:Catalysis; D004800:Enzymes, Immobilized / Q000378:metabolism; D004952:Esters; D005227:Fatty Acids / Q000737:chemistry; D005419:Flavonoids / Q000096:biosynthesis* / Q000737:chemistry; D008049:Lipase / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry; D059808:Polyphenols
D004800:Enzymes, Immobilized; D004952:Esters; D005227:Fatty Acids; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D001104:Arbutin; D008049:Lipase