Timed tests of motor function in Parkinson's disease.
BACKGROUND
Timed tests of motor function in Parkinson's disease (PD) may be useful for the diagnosis of bradykinesia or to monitor disease progression or treatment response. However, normal ranges have not been established.


OBJECTIVE
To define normal ranges of hand-tapping and timed walking tests in non-parkinsonian controls and compare with PD patients' performance.


METHODS
We recruited PD patients and age- and gender-matched controls for a prospective community-based incidence study of parkinsonian disorders in North-East Scotland. We counted the times participants tapped between two counters in 30 s. We also timed a 6m get-up-and-go test. We assessed age and gender effects and calculated 95% reference ranges for controls. We compared PD patients with controls.


RESULTS
We recruited 157 controls and 138 newly diagnosed, untreated PD patients (mean ages 75 and 73). The 95% control reference range for tapping scores with the dominant hand was 18-74 taps. Males and younger participants performed significantly better. PD patients performed less well (mean difference 15 taps, p < 0.001) but only 10% had tapping scores below the control range. The 95% control reference range for the get-up-and-go test was 9-27 s. Walking times increased significantly with age, but gender had no effect. PD patients were slower (median difference 4.5s, p < 0.001) but only 17% were slower than the control range.


CONCLUSIONS
Although PD patients performed more slowly than matched controls, timed tests were not helpful diagnostically because few incident patients were outside the normal reference ranges. Further work is needed on their utility in monitoring disease progression.
Macleod
Angus D
AD
ST2 Doctor, Aberdeen Royal Infirmary, Aberdeen, UK. angusd123@gmail.com
Counsell
Carl E
CE
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006225:Hand / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D009068:Movement / Q000502:physiology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000502:physiology; D013998:Time Perception / Q000502:physiology*