Bisnicalaterines B and C, atropisomeric bisindole alkaloids from Hunteria zeylanica, showing vasorelaxant activity.
Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.
Hirasawa
Yusuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.
Hara
Mayumi
M
Nugroho
Alfarius E
AE
Sugai
Masatomo
M
Zaima
Kazumasa
K
Kawahara
Nobuo
N
Goda
Yukihiro
Y
Awang
Khalijah
K
Hadi
A Hamid A
AH
Litaudon
Marc
M
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects*; D029062:Apocynaceae / Q000737:chemistry* / Q000145:classification; D002478:Cells, Cultured; D002942:Circular Dichroism; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D009924:Organ Culture Techniques; D024301:Plant Bark / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D026121:Indole Alkaloids; D014665:Vasodilator Agents; C552158:bisnicalaterine B; C552159:bisnicalaterine C