title: Mixed testicular germ cell tumour in a patient with previous pineal germinoma.
abstract: Germ cell tumours (GCT) are a relatively common malignancy in men aged 15-35 years. They occur most frequently in the gonads, but 3-5% have extragonadal origin, mainly in the pineal gland, neurohypophysis, mediastinum and retroperitoneum. Although intracranial germinomas may present with synchronous midline lesions, development of metachronous testicular germ cell primaries seems to be extremely rare, and confirmed dissemination of intracranial GCT to the testes has never been reported. We report the case of a 32-year-old man, with previously treated pineal germinoma at age 16 years, who later developed mixed GCT of the left testis.
authors.affiliation: Department of Neurology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Professor Lima Basto, 1099-023, Lisbon, Portugal. vanessabrito.silva@hotmail.com
authors.forename: Vanessa B
authors.initials: VB
authors.lastname: Silva
authors.forename: Ana L
authors.initials: AL
authors.lastname: Azevedo
authors.forename: Ilda M
authors.initials: IM
authors.lastname: Costa
authors.forename: Manuela S
authors.initials: MS
authors.lastname: Mafra
authors.forename: José L
authors.initials: JL
authors.lastname: Passos-Coelho
authors.forename: José M
authors.initials: JM
authors.lastname: Bravo-Marques
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018237:Germinoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009919:Orchiectomy; D010871:Pinealoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
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