Octreotide reduces hepatic, renal and breast cystic volume in autosomal-dominant polycystic kidney disease.
A 43-year-old woman with autosomal-dominant polycystic kidney disease (ADPKD) received octreotide for 12 months, and this was associated with a 6.3% reduction in liver volume, an 8% reduction in total kidney volume and stabilization of renal function. There was also a reduction of cyst size in fibrocystic disease of breast. These data suggest that the cyst fluid accumulation in different organs from patients with ADPKD is a dynamic process which can be reversed by octreotide. This is the first report of a case of simultaneous reduction in hepatic, renal and breast cystic volume with preservation of renal function in a patient with ADPKD receiving octreotide.
Peces
Ramón
R
Servicio de Nefrología, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain. cpeces@varnetmail.com
Cuesta-López
Emilio
E
Peces
Carlos
C
Pérez-Dueñas
Virginia
V
Vega-Cabrera
Cristina
C
Selgas
Rafael
R
D000328:Adult; D047688:Breast Cyst / Q000188:drug therapy* / Q000209:etiology*; D003560:Cysts / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000188:drug therapy* / Q000209:etiology*; D008107:Liver Diseases / Q000188:drug therapy* / Q000209:etiology*; D015282:Octreotide / Q000627:therapeutic use*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*
D015282:Octreotide
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