Facile and efficient aromatization of 1,4-dihydropyridines with M(NO3)2.XH2O, TNCB, TBAP and HMTAI and preparation of deuterium labeled dehydronifedipine from nifedipine-d3.
The easy and efficient aromatization of various 1,4-dihydropyridines was investigated using various metal nitrates, trinitratocerium(IV) bromate (TNCB), and tetrabutyl ammonium periodate (TBAP) as oxidant in acetic acid at 100 degrees C, as well as hexamethylenetetramine-iodine (HMTAI) reflux in methanol. The efficient conversion of nifedipine-d(3) to dehydronifedipine-d(3) as an internal standard can be used in the measurement of nifedipine concentration in a body.
Shaikh
Ajam C
AC
Department of Chemistry, National Dong Hwa University, Soufeng, Hualien, Taiwan, ROC.
Chen
Chinpiao
C
D002121:Calcium Channel Blockers / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry*; D004095:Dihydropyridines / Q000737:chemistry*; D006801:Humans; D008670:Metals / Q000737:chemistry; D008709:Methenamine / Q000737:chemistry; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry* / Q000592:standards; D009566:Nitrates / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D014665:Vasodilator Agents / Q000737:chemistry
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D008670:Metals; D009566:Nitrates; D000644:Quaternary Ammonium Compounds; D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; C117802:dehydronifedipine; C038806:1,4-dihydropyridine; D003903:Deuterium; C009405:tetrabutylammonium; D009543:Nifedipine; D008709:Methenamine