Association of interaction between smoking and CYP 2C19*3 polymorphism with coronary artery disease in a Uighur population.
OBJECTIVE
Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation. The purpose of this study is to explore the relationship between the interaction of CYP2C19*3 polymorphism and smoking and coronary artery disease (CAD) in a Uighur population.


METHODS
In a Chinese Uighur case-control study of patients with CAD (n = 336) and healthy controls (n = 370), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis.


RESULTS
The CYP2C19*3 AG + AA genotype was significantly more prevalent in patients with CAD (6.25.0% vs 2.96%; P = .03). Multiple logistic regression analysis showed 4 independent risk factors: the interaction of CYP2C19*3 and smoking (OR 7.22, 95% confidence interval [CI] 2.32-10.23; P = .009), smoking (OR 3.23, 95% CI 1.72-5.44; P = .003), blood sugar (OR 2.12, 95% CI 1.03-4.21; P < .01), and hypertension (OR 1.74, 95% CI 0.98-2.34; P = .013).


CONCLUSIONS
The CYP2C19*3 polymorphism and CAD were synergistically and significantly associated in Chinese Uighur patients.
Yang
Yi-Ning
YN
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.
Wang
Xin-Lei
XL
Ma
Yi-Tong
YT
Xie
Xiang
X
Fu
Zhen-Yan
ZY
Li
Xiao-Mei
XM
Chen
Bang-Dang
BD
Liu
Fen
F
D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000209:etiology* / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism
D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19