Vesicle transport: a new player in APP trafficking.
The trafficking of the amyloid precursor protein (APP) is critical for controlling the generation of the toxic A beta peptide that is central to amyloid formation in Alzheimer's disease. A new study reveals a key role for the AP4 adaptor protein complex in the Golgi-to-endosome trafficking of APP.
Owen
David J
DJ
Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Collins
Brett M
BM
D000544:Alzheimer Disease / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D022161:Transport Vesicles / Q000502:physiology*
D016564:Amyloid beta-Protein Precursor; D026901:Membrane Transport Proteins