[IARC revision on dioxin and some dioxin-like compounds].
Since 1997 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has classified in Group 1 carcinogens by IARC essentially on based on mechanistic considerations. In the last review of human carcinogens IARC confirmed this classification also with epidemiological evidences. Following chemical-physical and mechanistics considerations, in particular the same AhR-mediated action, for two other dioxin-like compounds, the PCB126 and the PeCDF the classification in group 1 was suggested. This note reports and comments this IARC revision.
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Dipartimento di Medicina Sperimentale e Applicata, Sezione di Medicina del Lavoro e Igiene Industriale, Università degli Studi di Brescia, Italy.
D035843:Biomedical Research; D002273:Carcinogens / Q000145:classification*; D004147:Dioxins / Q000145:classification*; D006801:Humans; D007390:International Agencies; D008495:Medical Oncology
D002273:Carcinogens; D004147:Dioxins