title: Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.
abstract: Incorporation of zinc-binding groups into the side-chain of 1alpha,25-dihydroxyvitamin D(3) (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D.
authors.affiliation: Department of Chemistry, McGill University, Montreal, QC, Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Lamblin
authors.forename: Basel
authors.initials: B
authors.lastname: Dabbas
authors.forename: Russell
authors.initials: R
authors.lastname: Spingarn
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Mendoza-Sanchez
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Wang
authors.forename: Beum-Soo
authors.initials: BS
authors.lastname: An
authors.forename: Dao Chao
authors.initials: DC
authors.lastname: Huang
authors.forename: Richard
authors.initials: R
authors.lastname: Kremer
authors.forename: John H
authors.initials: JH
authors.lastname: White
authors.forename: James L
authors.initials: JL
authors.lastname: Gleason
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry*; D006801:Humans; D018167:Receptors, Calcitriol / Q000819:agonists*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D018167:Receptors, Calcitriol; C118756:dihydroxy-vitamin D3; D014807:Vitamin D; D015032:Zinc