title: Perioperative seizures following deep brain stimulation in patients with multiple sclerosis.
abstract: Following a total of 386 deep brain stimulation (DBS) procedures in Oxford, only two seizures have been recorded in the peri-operative period. Both patients had MS and underwent thalamic DBS for tremor and these 2 cases are presented here. The incidence of peri-operative seizures in MS patients undergoing DBS procedures is more than 8-fold greater than that expected for patients undergoing DBS procedures. Further experience with DBS procedures in MS patients is needed to determine whether there is a role for peri-operative anticonvulsants in these patients.
authors.affiliation: Nuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK. reubenjohnson@doctors.org.uk
authors.forename: Reuben D
authors.initials: RD
authors.lastname: Johnson
authors.forename: Syed R
authors.initials: SR
authors.lastname: Qadri
authors.forename: C
authors.initials: C
authors.lastname: Joint
authors.forename: L
authors.initials: L
authors.lastname: Moir
authors.forename: A L
authors.initials: AL
authors.lastname: Green
authors.forename: T Z
authors.initials: TZ
authors.lastname: Aziz
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications*; D012640:Seizures / Q000209:etiology* / Q000601:surgery; D016896:Treatment Outcome; D014202:Tremor / Q000150:complications / Q000628:therapy*