title: Anatomical and functional connectivity of cytoarchitectonic areas within the human parietal operculum.
abstract: In monkeys, the somatosensory cortex on the parietal operculum can be differentiated into several distinct cortical fields. Potential human homologues for these areas have already been defined by cytoarchitectonic mapping and functional imaging experiments. Differences between the two most widely studied areas [operculum parietale (OP) 1 and OP 4] within this region particularly pertain to their connection with either the perceptive parietal network or the frontal motor areas. In the present study, we investigated differences in anatomical connection patterns probed by probabilistic tractography on diffusion tensor imaging data. Functional connectivity was then mapped by coordinate-based meta-analysis of imaging studies. Comparison between these two aspects of connectivity showed a good congruency and hence converging evidence for an involvement of these areas in matching brain networks. There were, however, also several instances in which anatomical and functional connectivity diverged, underlining the independence of these measures and the need for multimodal characterization of brain connectivity. The connectivity analyses performed showed that the two largest areas within the human parietal operculum region display considerable differences in their connectivity to frontoparietal brain regions. In particular, relative to OP 1, area OP 4 is more closely integrated with areas responsible for basic sensorimotor processing and action control, while OP 1 is more closely connected to the parietal networks for higher order somatosensory processing. These results are largely congruent with data on nonhuman primates. Differences between anatomical and functional connectivity as well as between species, however, highlight the need for an integrative view on connectivity, including comparison and cross-validation of results from different approaches.
authors.affiliation: Department of Psychiatry and Psychotherapy, Rheinisch-Westfälische Technische Hochschule Aachen University, D-52074 Aachen, Germany. S.Eickhoff@fz-juelich.de
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.forename: Saad
authors.initials: S
authors.lastname: Jbabdi
authors.forename: Svenja
authors.initials: S
authors.lastname: Caspers
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.forename: Timothy E J
authors.initials: TE
authors.lastname: Behrens
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D016208:Databases, Factual; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology
references.citation: J Neurosci. 2004 Jun 9;24(23):5391-9
references.pmid: 15190112
references.citation: Cereb Cortex. 2008 Sep;18(9):2141-57
references.pmid: 18245042
references.citation: J Comp Neurol. 1989 Apr 8;282(2):169-90
references.pmid: 2496153
references.citation: J Neurophysiol. 1993 Jul;70(1):444-7
references.pmid: 8360721
references.citation: Neuroimage. 2008 Jul 15;41(4):1382-94
references.pmid: 18486490
references.citation: Nature. 1996 Aug 29;382(6594):805-7
references.pmid: 8752272
references.citation: Front Neuroinform. 2009 Jul 09;3:23
references.pmid: 19636392
references.citation: J Neurophysiol. 2001 May;85(5):2236-44
references.pmid: 11353038
references.citation: Clin Neurophysiol. 2002 Oct;113(10):1573-8
references.pmid: 12350433
references.citation: Cereb Cortex. 2006 Feb;16(2):254-67
references.pmid: 15888607
references.citation: Brain Struct Funct. 2008 Aug;212(6):481-95
references.pmid: 18651173
references.citation: J Comp Neurol. 2006 Mar 1;495(1):53-69
references.pmid: 16432904
references.citation: J Comp Neurol. 1995 May 15;355(4):539-62
references.pmid: 7636030
references.citation: Philos Trans A Math Phys Eng Sci. 2009 Jun 13;367(1896):2399-421
references.pmid: 19414462
references.citation: Eur J Neurosci. 1995 Sep 1;7(9):1934-41
references.pmid: 8528469
references.citation: Cereb Cortex. 2008 Nov;18(11):2553-9
references.pmid: 18296434
references.citation: J Comp Neurol. 2000 Feb 28;418(1):1-21
references.pmid: 10701752
references.citation: J Neurol Neurosurg Psychiatry. 1997 Oct;63(4):501-5
references.pmid: 9343131
references.citation: Hum Brain Mapp. 2008 Feb;29(2):207-21
references.pmid: 17390318
references.citation: Nature. 2000 Mar 9;404(6774):187-90
references.pmid: 10724171
references.citation: Neuron. 2003 Oct 30;40(3):643-53
references.pmid: 14642286
references.citation: Neuroimage. 2010 Apr 15;50(3):1148-67
references.pmid: 20056149
references.citation: Exp Brain Res. 2000 Jul;133(1):55-65
references.pmid: 10933210
references.citation: Physiol Rev. 1983 Jan;63(1):206-31
references.pmid: 6401864
references.citation: Anat Embryol (Berl). 2005 Dec;210(5-6):373-86
references.pmid: 16249867
references.citation: J Neurophysiol. 2009 Jun;101(6):3246-57
references.pmid: 19357343
references.citation: Cereb Cortex. 1997 Jan-Feb;7(1):3-17
references.pmid: 9023428
references.citation: Nat Neurosci. 2003 Jul;6(7):750-7
references.pmid: 12808459
references.citation: Adv Anat Embryol Cell Biol. 2004;174:I-VIII, 1-89
references.pmid: 14750415
references.citation: J Neurosci. 1990 Mar;10(3):952-74
references.pmid: 2108231
references.citation: J Comp Neurol. 2002 Feb 4;443(2):168-82
references.pmid: 11793354
references.citation: Hum Brain Mapp. 2010 Feb;31(2):173-84
references.pmid: 19603407
references.citation: Neuroimage. 1999 Jul;10(1):63-83
references.pmid: 10385582
references.citation: Nat Neurosci. 2002 Nov;5(11):1217-25
references.pmid: 12368806
references.citation: Neuroimage. 2001 Sep;14(3):617-31
references.pmid: 11506535
references.citation: Ann Neurol. 2008 Feb;63(2):236-46
references.pmid: 17896791
references.citation: Cereb Cortex. 2008 Apr;18(4):846-67
references.pmid: 17644831
references.citation: J Comp Neurol. 1999 Sep 20;412(2):319-41
references.pmid: 10441759
references.citation: J Comp Neurol. 2006 Apr 20;495(6):691-708
references.pmid: 16506197
references.citation: Neuroimage. 2006 Nov 1;33(2):430-48
references.pmid: 16949304
references.citation: Cereb Cortex. 1999 Oct-Nov;9(7):662-74
references.pmid: 10554989
references.citation: Curr Opin Neurobiol. 2005 Dec;15(6):623-5
references.pmid: 16271463
references.citation: Neuroimage. 2006 Aug 15;32(2):570-82
references.pmid: 16781166
references.citation: Cereb Cortex. 2007 Aug;17(8):1800-11
references.pmid: 17032710
references.citation: Neuroimage. 2006 Jul 1;31(3):1004-14
references.pmid: 16529950
references.citation: J Physiol Paris. 2006 Jun;99(4-6):414-24
references.pmid: 16730432
references.citation: J Neurosci. 2004 Dec 8;24(49):11193-204
references.pmid: 15590936
references.citation: Exp Brain Res. 1983;51(2):247-60
references.pmid: 6617794
references.citation: J Neurosci. 2006 Jun 14;26(24):6473-84
references.pmid: 16775135
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
references.pmid: 19620724
references.citation: J Comp Neurol. 1992 Mar 1;317(1):1-30
references.pmid: 1573055
references.citation: Somatosens Mot Res. 2008 Sep;25(3):149-62
references.pmid: 18821280
references.citation: Hum Brain Mapp. 2006 Jul;27(7):611-21
references.pmid: 16281284
references.citation: Neuroimage. 1992 Aug;1(1):43-53
references.pmid: 9343556
references.citation: Neuroreport. 2002 May 7;13(6):813-9
references.pmid: 11997693
references.citation: Neuroimage. 2002 Jul;16(3 Pt 1):765-80
references.pmid: 12169260
references.citation: Magn Reson Med. 2003 Nov;50(5):1077-88
references.pmid: 14587019
references.citation: J Neurosci. 2006 Jun 14;26(24):6485-95
references.pmid: 16775136
references.citation: Neuroimage. 2007 Jan 1;34(1):144-55
references.pmid: 17070705
references.citation: J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205
references.pmid: 8126267
references.citation: J Comp Neurol. 1980 Jul 1;192(1):93-108
references.pmid: 7410615
references.citation: Nat Rev Neurosci. 2002 Apr;3(4):319-21
references.pmid: 11967563
references.citation: J Comp Neurol. 2003 Aug 4;462(4):382-99
references.pmid: 12811808
references.citation: Cereb Cortex. 2006 Feb;16(2):268-79
references.pmid: 15888606
references.citation: Neuroimage. 2004;23 Suppl 1:S208-19
references.pmid: 15501092
references.citation: J Neurosci. 2009 Nov 18;29(46):14496-505
references.pmid: 19923283
references.citation: Adv Neurol. 2003;93:57-67
references.pmid: 12894401
references.citation: J Neurosci. 2007 Sep 19;27(38):10259-69
references.pmid: 17881532
references.citation: Neuroimage. 2000 Jun;11(6 Pt 1):684-96
references.pmid: 10860796
references.citation: Hum Brain Mapp. 2009 Sep;30(9):2907-26
references.pmid: 19172646
references.citation: Prog Neurobiol. 2002 Oct;68(2):113-43
references.pmid: 12450490
references.citation: Cereb Cortex. 2006 Oct;16(10):1418-30
references.pmid: 16306320
references.citation: J Comp Neurol. 2004 Aug 30;476(4):363-87
references.pmid: 15282711
references.citation: J Comp Neurol. 1999 Jan 5;403(1):5-32
references.pmid: 10075440
references.citation: Eur J Neurosci. 2005 Sep;22(5):1239-47
references.pmid: 16176367
references.citation: J Neurosci. 1995 May;15(5 Pt 2):3821-39
references.pmid: 7751949
references.citation: Neuroimage. 2004 May;22(1):42-56
references.pmid: 15109996
references.citation: Hum Brain Mapp. 1996;4(1):58-73
references.pmid: 20408186
references.citation: J Comp Neurol. 1986 Oct 15;252(3):348-73
references.pmid: 3793981
references.citation: Neuroimage. 2005 Jul 1;26(3):839-51
references.pmid: 15955494
references.citation: Neuroimage. 2005 May 1;25(4):1325-35
references.pmid: 15850749
references.citation: J Comp Neurol. 1999 Jan 25;403(4):431-58
references.pmid: 9888311
references.citation: J Neurosci. 2005 Jun 22;25(25):5984-7
references.pmid: 15976087
references.citation: Hum Brain Mapp. 2005 May;25(1):155-64
references.pmid: 15846811
references.citation: Trends Cogn Sci. 2004 Jul;8(7):315-24
references.pmid: 15242691