title: Aqueous-phase Suzuki-Miyaura cross-coupling reactions catalyzed by Pd-NHC complexes.
abstract: Cleavage reactions of [PdBr(2)(NHC)](2) with two equiv. of pyridine derivatives (L), having one or two carboxylic acid groups [L = NC(5)H(4)-2-COOH, NC(5)H(4)-3-COOH, NC(5)H(4)-4-COOH, or NC(5)H(3)-2,6-(COOH)(2) in chloroform or DMSO, respectively, afforded the monomeric mixed ligand complexes trans-[PdBr(2)(NHC)L] (1-4) which, due to deprotonation of the carboxylic acid functionality, are water soluble in KOH. The catalytic activity of complexes 1-4 in aqueous Suzuki-Miyaura cross-coupling reactions were evaluated and compared. The dicarboxylic functionality enhances the catalyst reactivity and stability and the carboxylate derived from 4 could be easily recovered and reused for several cycles under the mild reaction conditions.
authors.affiliation: Department of Chemistry, Ege University, 35100, Bornova-Izmir, Turkey.
authors.forename: Hayati
authors.initials: H
authors.lastname: Türkmen
authors.forename: Rahime
authors.initials: R
authors.lastname: Can
authors.forename: Bekir
authors.initials: B
authors.lastname: Cetinkaya