Relationship between alcohol consumption and serum adiponectin levels: the Takahata study--a cross-sectional study of a healthy Japanese population.
BACKGROUND
The relationship between alcohol consumption and serum adiponectin levels has not been fully explored in an Asian population.


OBJECTIVE
Our goal was to determine whether alcohol consumption is associated with a change in adiponectin levels in a healthy Japanese population.


METHODS
This was a cross-sectional study.


METHODS
Subjects were recruited from participants in a health check-up program.


METHODS
This study included 2932 subjects (1306 men and 1626 women).


METHODS
The effects of total weekly or daily volume of ethanol intake on serum adiponectin levels were evaluated. In addition, the correlation of clinical traits with serum adiponectin levels was examined. A multivariate regression model was used to control for possible confounding factors.


RESULTS
Alcohol consumption was weakly correlated with decreased serum adiponectin levels in men [Spearman's ordered correlation coefficient (rs=-0.141; P<0.001]; an even weaker correlation was seen in women (rs=-0.055; P=0.025). Multivariate analysis demonstrated that alcohol consumption was independently associated with hypoadiponectinemia.


CONCLUSIONS
In contrast to reports from the United States and Europe among White and Black subjects, our study demonstrated an inverse association between alcohol intake and serum adiponectin levels in Asian subjects, suggesting ethnic differences in the effects of alcohol consumption on serum adiponectin levels.
Nishise
Yuko
Y
Department of Gastroenterology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. ynishise-gi@umin.ac.jp
Saito
Takafumi
T
Makino
Naohiko
N
Okumoto
Kazuo
K
Ito
Jun-Itsu
JI
Watanabe
Hisayoshi
H
Saito
Koji
K
Togashi
Hitoshi
H
Ikeda
Chisaki
C
Kubota
Isao
I
Daimon
Makoto
M
Kato
Takeo
T
Fukao
Akira
A
Kawata
Sumio
S
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000097:blood*; D044466:Asian People; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006306:Health Surveys; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012907:Smoking
D052242:Adiponectin