title: Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.
abstract: The adaptor protein SLP-76 is expressed in multiple hematopoietic lineages including T cells, platelets, and neutrophils. SLP-76 mediated signaling is dependent on its multiple protein interaction domains, as it creates a scaffold on which key signaling complexes are built. SLP-76 is critical for supporting signaling downstream of both immunoreceptors and integrins. The signaling molecules used both upstream and downstream of SLP-76 are similar among these receptors and across cell types; however, important differences exist. Appreciating how SLP-76 coordinates signal transduction across different cell and receptor types provides insights into the complex interplay of pathways critical for activation of cells of the immune system that are essential for host defense.
authors.affiliation: Abramson Family Cancer Institute, University of Pennsylvania, Philadelphia, 19104, USA.
authors.forename: Martha S
authors.initials: MS
authors.lastname: Jordan
authors.forename: Gary A
authors.initials: GA
authors.lastname: Koretzky
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D019070:Cell Lineage; D006413:Hematopoietic System / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D011946:Receptors, Antigen / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D011946:Receptors, Antigen; C092947:SLP-76 signal Transducing adaptor proteins
references.citation: Mol Cell Biol. 2009 Oct;29(20):5578-89
references.pmid: 19667077
references.citation: Mol Cell Biol. 2006 Sep;26(17):6727-38
references.pmid: 16914752
references.citation: Immunity. 1998 Nov;9(5):607-16
references.pmid: 9846482
references.citation: J Biol Chem. 2004 Apr 9;279(15):15481-90
references.pmid: 14722089
references.citation: J Immunol. 2007 Apr 1;178(7):4606-14
references.pmid: 17372019
references.citation: Curr Biol. 1999 Jan 28;9(2):67-75
references.pmid: 10021361
references.citation: Curr Biol. 2001 Nov 13;11(22):1799-804
references.pmid: 11719224
references.citation: Eur J Immunol. 2007 Oct;37(10):2961-72
references.pmid: 17823979
references.citation: Immunity. 2006 Jul;25(1):93-104
references.pmid: 16860760
references.citation: Blood. 2009 Jul 2;114(1):74-84
references.pmid: 19401562
references.citation: J Immunol. 2009 Nov 1;183(9):5756-67
references.pmid: 19812192
references.citation: J Immunol. 2001 May 1;166(9):5654-64
references.pmid: 11313406
references.citation: J Immunol. 1999 Sep 15;163(6):3143-52
references.pmid: 10477581
references.citation: J Exp Med. 2007 Mar 19;204(3):681-91
references.pmid: 17353368
references.citation: Immunity. 2008 Mar;28(3):359-69
references.pmid: 18342008
references.citation: J Biol Chem. 2001 Nov 30;276(48):45207-16
references.pmid: 11487585
references.citation: Science. 1998 Jul 17;281(5375):416-9
references.pmid: 9665885
references.citation: J Biol Chem. 1997 May 2;272(18):11674-7
references.pmid: 9115214
references.citation: Mol Cell Biol. 2006 Sep;26(18):6936-49
references.pmid: 16943434
references.citation: J Immunol. 2003 Aug 1;171(3):1360-8
references.pmid: 12874226
references.citation: Immunity. 2008 Jun;28(6):810-21
references.pmid: 18549800
references.citation: J Biol Chem. 1996 Aug 16;271(33):19641-4
references.pmid: 8702662
references.citation: J Biol Chem. 2005 Mar 4;280(9):8364-70
references.pmid: 15623534
references.citation: J Immunol. 2004 Jun 1;172(11):6768-74
references.pmid: 15153494
references.citation: Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):884-9
references.pmid: 11792851
references.citation: J Clin Invest. 1999 Jan;103(1):19-25
references.pmid: 9884330
references.citation: Curr Biol. 2002 Aug 6;12(15):1336-41
references.pmid: 12176364
references.citation: Immunity. 2003 Nov;19(5):761-9
references.pmid: 14614862
references.citation: J Allergy Clin Immunol. 2009 Nov;124(5):1088-98
references.pmid: 19895996
references.citation: Curr Biol. 2003 Sep 16;13(18):1619-24
references.pmid: 13678593
references.citation: J Exp Med. 2005 Oct 3;202(7):893-900
references.pmid: 16186188
references.citation: Mol Cell Biol. 2006 Oct;26(19):7155-66
references.pmid: 16980618
references.citation: Nat Struct Mol Biol. 2006 Sep;13(9):798-805
references.pmid: 16906159
references.citation: Nat Immunol. 2006 Dec;7(12):1326-33
references.pmid: 17086186
references.citation: J Biol Chem. 1997 Oct 3;272(40):25401-8
references.pmid: 9312162
references.citation: Cell. 1998 Jan 9;92(1):83-92
references.pmid: 9489702
references.citation: Science. 1998 Jul 17;281(5375):413-6
references.pmid: 9665884
references.citation: Eur J Immunol. 1999 Nov;29(11):3702-11
references.pmid: 10556826
references.citation: Nat Immunol. 2007 Jan;8(1):84-91
references.pmid: 17115060
references.citation: J Biol Chem. 1995 Mar 31;270(13):7029-32
references.pmid: 7706237
references.citation: Cell. 1998 Jul 24;94(2):229-38
references.pmid: 9695951
references.citation: Mol Cell Biol. 2001 Jul;21(13):4208-18
references.pmid: 11390650
references.citation: Science. 2003 Jan 10;299(5604):247-51
references.pmid: 12522250
references.citation: J Clin Invest. 1999 Jun;103(12):1737-43
references.pmid: 10377180
references.citation: J Immunol. 2005 Feb 1;174(3):1385-92
references.pmid: 15661896
references.citation: J Biol Chem. 1998 Dec 18;273(51):34437-43
references.pmid: 9852111
references.citation: J Biol Chem. 2007 Feb 2;282(5):2937-46
references.pmid: 17148460
references.citation: J Exp Med. 1999 May 3;189(9):1383-90
references.pmid: 10224278
references.citation: Immunity. 2000 Apr;12(4):399-408
references.pmid: 10795738
references.citation: Science. 2001 Sep 21;293(5538):2260-3
references.pmid: 11567140
references.citation: Mol Cell Biol. 2006 Oct;26(19):7130-44
references.pmid: 16980616
references.citation: Immunity. 2006 Jul;25(1):79-91
references.pmid: 16860759
references.citation: J Thromb Haemost. 2008 Dec;6(12):2152-9
references.pmid: 18826392
references.citation: Immunity. 1997 Feb;6(2):155-64
references.pmid: 9047237
references.citation: J Biol Chem. 2000 Jan 21;275(3):2219-30
references.pmid: 10636929
references.citation: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12056-61
references.pmid: 11050236
references.citation: J Exp Med. 2002 Mar 18;195(6):705-17
references.pmid: 11901197
references.citation: Immunol Rev. 2007 Aug;218:9-28
references.pmid: 17624941
references.citation: Immunity. 2001 Dec;15(6):1011-26
references.pmid: 11754821
references.citation: Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19063-8
references.pmid: 16354835
references.citation: Science. 2001 Sep 21;293(5538):2263-5
references.pmid: 11567141
references.citation: J Exp Med. 2004 Oct 18;200(8):1063-74
references.pmid: 15477347
references.citation: Mol Cell Biol. 2007 Jun;27(11):4070-81
references.pmid: 17403904
references.citation: J Exp Med. 2008 Aug 4;205(8):1775-88
references.pmid: 18663126
references.citation: Immunity. 1996 Jun;4(6):593-602
references.pmid: 8673706
references.citation: Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6638-43
references.pmid: 17420479
references.citation: J Immunol. 1997 Aug 15;159(4):1639-47
references.pmid: 9257823
references.citation: J Exp Med. 2002 May 6;195(9):1103-14
references.pmid: 11994416