The hydrolysis of phosphate diesters in cyclohexane and acetone.
The hydrolysis of phosphate diesters is one of the most difficult reactions known. Here we show that in acetone or cyclohexane, at 25 degrees C, phosphodiesters undergo hydrolysis 5 x 10(5) and 2 x 10(9)-fold more rapidly than in water, respectively, and that this rate enhancement is achieved by lowering the enthalpy of activation.
Stockbridge
Randy B
RB
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Wolfenden
Richard
R
D000096:Acetone / Q000737:chemistry*; D003510:Cyclohexanes / Q000737:chemistry*; D004952:Esters; D006868:Hydrolysis; D010710:Phosphates / Q000737:chemistry*; D013816:Thermodynamics
D003510:Cyclohexanes; D004952:Esters; D010710:Phosphates; D000096:Acetone; C506365:Cyclohexane
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