Correlation between plasma asymmetric dimethylarginine and different types of coronary heart disease.
OBJECTIVE
To monitor the changes of plasma asymmetric dimethylarginine (ADMA), nitric oxide (NO), and von Willebrand factor (vWF) levels in patients with stable angina pectoris (SAP) or acute coronary syndrome (ACS) and to evaluate the correlation between ADMA and different types of coronary heart disease.


METHODS
A total of 143 subjects were divided into a non-CHD group, a SAP group and an ACS group. Plasma levels of ADMA, NO and vWF were examined and their correlation with SAP or ACS was analyzed.


RESULTS
Compared with the non-CHO or the SAP group, ADMA level was elevated in the ACS group (P<0.05). The ADMA level tended to increase in the SAP group compared with the non-CHD group, but had no significant difference (P>0.05). Compared with the non-CHD group, NO level was decreased in both the SAP and ACS group (P<0.05), and it decreased more in ACS group than that in the SAP group (P<0.05); vWF levels were increased in both the SAP and ACS group compared with the non-CHD group (P<0.05). There was no significant difference in the plasma levels of vWF in the SAP and the ACS group (P>0.05).


CONCLUSIONS
The change of plasma ADMA level is closely correlated with acute coronary syndrome. ADMA might be a clinical marker for acute coronary syndrome.
Cao
Yu
Y
Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yang
Kan
K
Zhang
Zhihui
Z
Ouyang
Mao
M
Xiao
Li
L
D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000145:classification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
D015415:Biomarkers; D014841:von Willebrand Factor; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine