title: Bone marrow involvement in a patient with paracoccidioidomycosis: a rare presentation of juvenile form.
abstract: Paracoccidioides brasiliensis rarely shows bone marrow involvement and its response to treatment with itraconazole in children needs further assessment. We describe here a child with a juvenile disseminated form of paracoccidioidomycosis, which showed reticuloendothelial system involvement and the presence of Paracoccidioides brasiliensis in the bone marrow. The patient showed an effective and rapid response to itraconazole therapy.
authors.affiliation: Department of Infectious Diseases and Infection Control, Brigadeiro Hospital, São Paulo, SP, Brazil. ghpereira1@terra.com.br
authors.forename: Graziella Hanna
authors.initials: GH
authors.lastname: Pereira
authors.forename: Aline Queiroz
authors.initials: AQ
authors.lastname: Santos
authors.forename: Miriam
authors.initials: M
authors.lastname: Park
authors.forename: Patricia Rady
authors.initials: PR
authors.lastname: Muller
authors.forename: Soraia
authors.initials: S
authors.lastname: Padua
authors.forename: Raquel Ferrari
authors.initials: RF
authors.lastname: Marchesi
authors.forename: Vera Lucia
authors.initials: VL
authors.lastname: Aldred
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D001853:Bone Marrow / Q000382:microbiology* / Q000473:pathology; D002648:Child; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008198:Lymph Nodes / Q000473:pathology; D008853:Microscopy; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D010228:Paracoccidioides / Q000302:isolation & purification*; D010229:Paracoccidioidomycosis / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole
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