title: NF-kappaB signaling modulation by EBV and KSHV.
abstract: The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.
authors.affiliation: Department of Pathology, Botucatu School of Medicine, Sao Paulo State University (UNESP), Rubiao Junior, s/n - Botucatu, SP 18618-000, Brazil.
authors.forename: Deilson Elgui
authors.initials: DE
authors.lastname: de Oliveira
authors.forename: Gianna
authors.initials: G
authors.lastname: Ballon
authors.forename: Ethel
authors.initials: E
authors.lastname: Cesarman
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015967:Gene Expression Regulation, Viral; D006566:Herpesviridae Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D015398:Signal Transduction
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D016328:NF-kappa B