PRKAR1A and the evolution of pituitary tumors.
Carney complex (CNC) is an inherited tumor predisposition associated with pituitary tumors, including GH-producing pituitary adenomas and rare reports of prolactinomas. This disease is caused by mutations in PRKAR1A, which encodes the type 1A regulatory subunit of the cAMP-dependent protein kinase, PKA. Loss of PRKAR1A causes enhanced PKA signaling, which leads to pituitary tumorigenesis. Mutations in the gene have not been detected in sporadic pituitary tumors, but there is some data to suggest that non-genomic mechanisms may cause loss of protein expression. Unlike CNC patients, mice heterozygous for Prkar1a mutations do not develop pituitary tumors, although complete knockout of the gene in the Pit1 lineage of the pituitary produces GH-secreting pituitary adenomas. These data indicate that complete loss of Prkar1a/PRKAR1A is able to cause pituitary tumors in mice and men. The pattern of tumors is likely related to the signaling pathways employed in specific pituitary cell types.
Kirschner
Lawrence S
LS
Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA. Lawrence.Kirschner@osumc.edu
D000172:Acromegaly / Q000209:etiology; D000818:Animals; D056733:Carney Complex / Q000235:genetics*; D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit / Q000235:genetics*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000473:pathology; D006801:Humans; D051379:Mice; D009232:Myxoma / Q000209:etiology / Q000401:mortality; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology; D010911:Pituitary Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D015175:Prolactinoma / Q000378:metabolism / Q000473:pathology; D052683:Somatotrophs / Q000473:pathology
D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; C517834:PRKAR1A protein, human; C517835:Prkar1a protein, mouse; D017868:Cyclic AMP-Dependent Protein Kinases
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