Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression?
Two recent studies show that epigenetics and inflammation play a relevant role in the regulation of transformation and cancer cell self-renewal in breast tumours, opening up the possibility that cancer progression can be controlled by interfering with inflammation cascades. Struhl's group showed that transient activation of the Src oncoprotein induces transformation and self-renewal of immortal cells via an epigenetic switch involving NF-kappaB, Lin28, Let-7 microRNA and IL-6. Concomitantly, Wicha's laboratory developed a strategy to selectively target cancer stem cells, retarding tumour growth and reducing metastasis by blocking the IL-8 receptor CXCR1 using either an inhibitor, repertaxin or a specific blocking antibody.
Cabodi
Sara
S
Dept. of Oncological Sciences, Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin, Italy. sara.cabodi@unito.it
Taverna
Daniela
D
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019138:Antibodies, Blocking / Q000276:immunology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000235:genetics / Q000473:pathology*; D018450:Disease Progression; D044127:Epigenesis, Genetic; D005812:Genes, Switch / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D015850:Interleukin-6 / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D015688:Oncogene Protein pp60(v-src) / Q000378:metabolism; D023062:Receptors, Interleukin-8A / Q000037:antagonists & inhibitors / Q000276:immunology; D013449:Sulfonamides / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D019138:Antibodies, Blocking; D000970:Antineoplastic Agents; D015850:Interleukin-6; D023062:Receptors, Interleukin-8A; D013449:Sulfonamides; D015688:Oncogene Protein pp60(v-src); C490707:reparixin
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