title: Unravelling mononuclear phagocyte  heterogeneity.
abstract: When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research.
authors.affiliation: King's College London, Guy's Campus, London SE1 1UL, UK. frederic.geissmann@kcl.ac.uk
authors.forename: Frédéric
authors.initials: F
authors.lastname: Geissmann
authors.forename: Siamon
authors.initials: S
authors.lastname: Gordon
authors.forename: David A
authors.initials: DA
authors.lastname: Hume
authors.forename: Allan M
authors.initials: AM
authors.lastname: Mowat
authors.forename: Gwendalyn J
authors.initials: GJ
authors.lastname: Randolph
mesh_terms: D000818:Animals; D015415:Biomarkers; D018929:Cell Culture Techniques; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D022423:Myeloid Cells / Q000276:immunology; D010586:Phagocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D015415:Biomarkers
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