title: Upper gastrointestinal massive bleeding successfully treated intra-operatively with a collagen and thrombin-based high-viscosity gel for haemostasis. Case report.
abstract: A 57-year-old male patient was admitted in our Department for a non-variceal upper gastrointestinal massive bleeding. In accordance with the clinical guidelines, the patient underwent an early endoscopy (within 24 hours from admission), which showed the source of bleeding in the second portion of the duodenum. An endoscopic haemostatic injection with dilute adrenalin (epinephrine, 1:10.000) was then performed. After 8 hours, severe recidive bleeding occurred with reduced haemoglobin levels, which led us to an emergency surgical treatment. A gastric resection was performed, followed by the application of high-viscous gel (Floseal) into the source of bleeding within the duodenal lumen. This technique allowed to obtain a definitive haemostasis without long-term complications. Our experience suggests that the intra-operative application of Floseal can be an effective alternative to traditional haemostatic techniques in the emergency surgical treatment of upper gastrointestinal bleeding. This also provides additional time to perform other haemostatic techniques techniques avoiding the precarious haemodynamic conditions of a patient in emergency.
authors.affiliation: University of Perugia.
authors.forename: E
authors.initials: E
authors.lastname: Farinella
authors.forename: P
authors.initials: P
authors.lastname: Ronca
authors.forename: F
authors.initials: F
authors.lastname: La Mura
authors.forename: M
authors.initials: M
authors.lastname: Bravetti
authors.forename: A
authors.initials: A
authors.lastname: Spizzirri
authors.forename: V
authors.initials: V
authors.lastname: Napolitano
authors.forename: R
authors.initials: R
authors.lastname: Cirocchi
authors.forename: G
authors.initials: G
authors.lastname: Giustozzi
authors.forename: F
authors.initials: F
authors.lastname: Sciannameo
mesh_terms: D003094:Collagen / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D005782:Gels; D006489:Hemostatic Techniques; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012720:Severity of Illness Index; D013917:Thrombin / Q000627:therapeutic use*; D014783:Viscosity
chemical_list: D005782:Gels; D003094:Collagen; D013917:Thrombin