The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size.
BACKGROUND
The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, beta-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy.


OBJECTIVE
Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size.


METHODS
We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and 2-h plasma glucose, and fasting and 1-h C-peptide from an oral glucose tolerance test) and fetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose).


METHODS
We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California.


RESULTS
After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested.


CONCLUSIONS
The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population.
Ackerman
C M
CM
Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15-717, Chicago, IL 60611, USA.
Lowe
L P
LP
Lee
H
H
Chen
F
F
Hughes
E
E
Cholod
P
P
Dyer
A R
AR
Hayes
M G
MG
Metzger
B E
BE
Lowe
W L
WL
Urbanek
M
M
D000483:Alleles; D001724:Birth Weight / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics*; D002096:C-Peptide / Q000235:genetics; D005260:Female; D047109:Fetal Development / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics
D001786:Blood Glucose; D002096:C-Peptide
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