title: Herpes simplex virus type 1 persists in the aged brain through hypothetical expression of accessory genes.
abstract: Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer's disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses through an array of accessory genes. This mini-review focuses on these viral accessory genes that may shed light on the potential mechanisms of this enigmatic phenomenon in the elderly brain.
authors.affiliation: Faculty of Health and Nutrition, Shubun University, Aichi, Japan. mori@shubun-ac.jp
authors.forename: Isamu
authors.initials: I
authors.lastname: Mori
mesh_terms: D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000821:virology*; D001921:Brain / Q000821:virology; D020803:Encephalitis, Herpes Simplex / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D006561:Herpes Simplex / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000254:growth & development; D006801:Humans
references.citation: J Virol. 2005 May;79(10):6162-71
references.pmid: 15858001
references.citation: Lancet. 1997 Jan 25;349(9047):241-4
references.pmid: 9014911
references.citation: J Neurovirol. 2007;13(1):56-66
references.pmid: 17454449
references.citation: Cell Host Microbe. 2007 Mar 15;1(1):23-35
references.pmid: 18005679
references.citation: Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):843-8
references.pmid: 9023344
references.citation: J Neuroimmunol. 2010 Mar 30;220(1-2):1-9
references.pmid: 19819030
references.citation: Neuropathol Appl Neurobiol. 1994 Jun;20(3):253-60
references.pmid: 7936075
references.citation: Microbes Infect. 2006 Aug;8(9-10):2556-62
references.pmid: 16859952
references.citation: J Med Virol. 2005 Feb;75(2):300-6
references.pmid: 15602731
references.citation: Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9411-6
references.pmid: 15192152
references.citation: J Alzheimers Dis. 2009;16(1):1-14
references.pmid: 19158416
references.citation: EMBO J. 1996 Jul 1;15(13):3256-66
references.pmid: 8670826
references.citation: Virol J. 2008 Nov 21;5:140
references.pmid: 19025601
references.citation: Blood. 2009 Apr 2;113(14):3264-75
references.pmid: 18952891
references.citation: Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):978-83
references.pmid: 11773630
references.citation: Biochemistry. 2000 May 23;39(20):5988-94
references.pmid: 10821670
references.citation: J Virol. 2004 Feb;78(4):1675-84
references.pmid: 14747533
references.citation: Neurosci Lett. 2007 Dec 18;429(2-3):95-100
references.pmid: 17980964
references.citation: J Neurovirol. 2008 Jan;14(1):1-4
references.pmid: 18300070
references.citation: J Virol. 2002 Mar;76(5):2029-35
references.pmid: 11836380
references.citation: Glia. 2001 Nov;36(2):118-24
references.pmid: 11596120
references.citation: J Virol. 2009 Oct;83(20):10677-83
references.pmid: 19656888
references.citation: J Virol. 2009 Sep;83(18):9131-9
references.pmid: 19587058
references.citation: J Neuropathol Exp Neurol. 2006 Oct;65(10):1022-30
references.pmid: 17021407
references.citation: J Alzheimers Dis. 2009;16(2):341-50
references.pmid: 19221424
references.citation: J Immunol. 2001 Oct 1;167(7):3928-35
references.pmid: 11564811
references.citation: Cell Death Differ. 2003 Dec;10(12):1320-8
references.pmid: 12934063
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2827-32
references.pmid: 16477041
references.citation: J Gen Virol. 2010 Apr;91(Pt 4):858-66
references.pmid: 19955563
references.citation: Autophagy. 2006 Jan-Mar;2(1):24-9
references.pmid: 16874088
references.citation: J Gen Virol. 2000 Mar;81(Pt 3):649-62
references.pmid: 10675402
references.citation: J Virol. 2004 Sep;78(18):10193-6
references.pmid: 15331752
references.citation: J Alzheimers Dis. 2008 May;13(4):393-405
references.pmid: 18487848
references.citation: J Pathol. 2009 Jan;217(1):131-8
references.pmid: 18973185
references.citation: J Biol Chem. 2002 Sep 20;277(38):35019-24
references.pmid: 12119288
references.citation: J Neurovirol. 2005 Apr;11(2):129-37
references.pmid: 16036791
references.citation: J Virol. 2003 Jun;77(12):7101-5
references.pmid: 12768029
references.citation: J Virol. 2009 Sep;83(17):8315-26
references.pmid: 19570876
references.citation: J Virol. 2002 Jul;76(14):6974-86
references.pmid: 12072498
references.citation: J Neurol Neurosurg Psychiatry. 1984 Nov;47(11):1247-50
references.pmid: 6094737
references.citation: J Virol. 2009 May;83(10):4791-9
references.pmid: 19279108
references.citation: J Virol. 2009 Dec;83(23):12164-71
references.pmid: 19759141
references.citation: Rev Med Virol. 2004 Jan-Feb;14(1):33-46
references.pmid: 14716690
references.citation: Science. 2008 Oct 10;322(5899):268-71
references.pmid: 18845757
references.citation: J Immunol. 2003 Dec 15;171(12):6733-41
references.pmid: 14662877
references.citation: J Med Virol. 2004 Sep;74(1):102-6
references.pmid: 15258975
references.citation: J Virol. 2002 Sep;76(18):9232-41
references.pmid: 12186907
references.citation: J Med Virol. 2004 Aug;73(4):605-11
references.pmid: 15221907
references.citation: Virology. 2000 Dec 20;278(2):309-21
references.pmid: 11118355