title: Diabetes mellitus as a risk factor for the development of lumbar spinal stenosis.
abstract: BACKGROUND
  Diabetes mellitus is a multi-organ disorder affecting many types of connective tissues, including bone and cartilage. Certain skeletal changes are more prevalent in diabetic patients than in non-diabetic individuals. A possible association of diabetes mellitus and lumbar spinal stenosis has been raised.
  
  
  OBJECTIVE
  To compare the prevalence of diabetes mellitus in patients with spinal stenosis, degenerative disk disease or osteoporotic vertebral fractures.
  
  
  METHODS
  A cross-sectional analysis was performed of 395 consecutive patients diagnosed with spinal stenosis, degenerative disk disease or osteoporotic vertebral fractures. All the patients were examined by one senior author in the outpatient orthopedic clinic of a large general hospital between June 2004 and January 2006 and diagnosed as having lumbar spinal stenosis (n=225), degenerative disk disease (n=124), or osteoporotic vertebral fractures (n=46).
  
  
  RESULTS
  The prevalence of diabetes mellitus in the three groups (spinal stenosis, osteoporotic fracture, degenerative disk disease) was 28%, 6.5% and 12.1%, respectively, revealing a significantly higher prevalence in the spinal stenosis group compared with the others (P=0.001). The higher prevalence of diabetes in the stenotic patients was unrelated to the presence of degenerative spondylolisthesis.
  
  
  CONCLUSIONS
  There is an association between diabetes and lumbar spinal stenosis. Diabetes mellitus may be a predisposing factor for the development of lumbar spinal stenosis.
authors.affiliation: Spine Unit, Assaf Harofeh Medical Center, Zerifin, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: Yoram
authors.initials: Y
authors.lastname: Anekstein
authors.forename: Yossi
authors.initials: Y
authors.lastname: Smorgick
authors.forename: Raphael
authors.initials: R
authors.lastname: Lotan
authors.forename: Gabriel
authors.initials: G
authors.lastname: Agar
authors.forename: Ehud
authors.initials: E
authors.lastname: Shalmon
authors.forename: Yizhar
authors.initials: Y
authors.lastname: Floman
authors.forename: Yigal
authors.initials: Y
authors.lastname: Mirovsky
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008159:Lumbar Vertebrae / Q000293:injuries; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications; D015995:Prevalence; D012307:Risk Factors; D016103:Spinal Fractures / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D013130:Spinal Stenosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D013168:Spondylolisthesis / Q000150:complications / Q000378:metabolism / Q000473:pathology