Breakfast with glycomacropeptide compared with amino acids suppresses plasma ghrelin levels in individuals with phenylketonuria.
Phenylketonuria (PKU) requires a lifelong low-phenylalanine (phe) diet where protein needs are met by consumption of a phe-free amino acid (AA) formula; complaints of persistent hunger are common. Foods made with glycomacropeptide (GMP), an intact protein that contains minimal phe and may promote satiety, provide an alternative to AA formula. The objective was to assess the ability of a GMP breakfast to promote satiety and affect plasma concentrations of AAs, insulin, and the appetite stimulating hormone ghrelin in those with PKU, when compared to an AA-based breakfast. Eleven PKU subjects (8 adults and 3 boys ages 11-14) served as their own controls in an inpatient metabolic study with two 4-day treatments: an AA-based diet followed by a diet replacing all AA formula with GMP foods. Plasma concentrations of AAs, insulin and ghrelin were obtained before and/or 180 min after breakfast. Satiety was assessed using a visual analog scale before, immediately after and 150 min after breakfast. Postprandial ghrelin concentration was significantly lower (p=0.03) with GMP compared to an AA-based breakfast, with no difference in fasting ghrelin. Lower postprandial ghrelin concentrations were associated with greater feelings of fullness after breakfast suggesting greater satiety with GMP compared to AAs. Postprandial concentrations of insulin and total plasma AAs were higher after a GMP breakfast compared to an AA-based breakfast consistent with slower absorption and less degradation of AAs from GMP. These results show sustained ghrelin suppression, and suggest greater satiety with ingestion of a meal containing GMP compared with AAs.
MacLeod
Erin L
EL
Department of Nutritional Sciences, 1415 Linden Dr., University of Wisconsin, Madison, Wisconsin 53706, USA.
Clayton
Murray K
MK
van Calcar
Sandra C
SC
Ney
Denise M
DM
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood / Q000494:pharmacology*; D002364:Caseins / Q000494:pharmacology*; D002648:Child; D004032:Diet; D005260:Female; D005502:Food; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009042:Motivation; D010147:Pain Measurement; D010446:Peptide Fragments / Q000494:pharmacology*; D010661:Phenylketonurias / Q000097:blood* / Q000178:diet therapy*; D019518:Postprandial Period; D012528:Satiety Response / Q000187:drug effects; D055815:Young Adult
D000596:Amino Acids; D002364:Caseins; D054439:Ghrelin; D007328:Insulin; D010446:Peptide Fragments; C065989:caseinomacropeptide
NIH Consens Statement. 2000 Oct 16-18;17(3):1-33
11757784
Am J Clin Nutr. 2005 Jul;82(1):41-8
16002798
Am J Physiol Endocrinol Metab. 2000 May;278(5):E877-84
10780944
Physiol Behav. 2009 Mar 23;96(4-5):675-82
19385022
Endocrinology. 2005 Feb;146(2):845-50
15528308
N Engl J Med. 2002 May 23;346(21):1623-30
12023994
J Inherit Metab Dis. 2007 Apr;30(2):153-8
17334706
J Inherit Metab Dis. 2002 Sep;25(5):333-46
12408183
J Inherit Metab Dis. 2009 Feb;32(1):58-64
19191005
Eur J Clin Nutr. 1999 Jun;53(6):495-502
10403587
J Clin Endocrinol Metab. 2004 Aug;89(8):3983-7
15292337
Appetite. 2009 Apr;52(2):388-95
19101599
J Clin Endocrinol Metab. 2008 May;93(5):1971-9
18198223
Am J Clin Nutr. 2006 Jan;83(1):89-94
16400055
Am J Clin Nutr. 2008 May;87(5):1576S-1581S
18469291
J Inherit Metab Dis. 2009 Feb;32(1):32-9
18956251
Endocrinology. 2002 Jan;143(1):185-90
11751608
Am J Clin Nutr. 2009 Sep;90(3):838S-843S
19640948
J Food Sci. 2009 May-Jul;74(4):E199-206
19490325
Physiol Behav. 2009 Jan 8;96(1):162-8
18948128
J Inherit Metab Dis. 2003;26(4):319-26
12971419
J Am Coll Nutr. 2007 Dec;26(6):704S-12S
18187437
J Inherit Metab Dis. 2007 Apr;30(2):202-8
17347917
Physiol Behav. 2006 Aug 30;89(1):71-84
16859720
JPEN J Parenter Enteral Nutr. 1991 Jan-Feb;15(1):48-53
2008034
J Nutr. 2001 Jul;131(7):1965-72
11435515
J Nutr. 2004 Nov;134(11):3011-5
15514267
Ann Nutr Metab. 2007;51(4):352-8
17726313
Am J Clin Nutr. 2002 Nov;76(5):1023-30
12399274
Gastroenterology. 2005 Jan;128(1):175-91
15633135
Am J Clin Nutr. 2009 Oct;90(4):1011-22
19692493
Diabetes. 2001 Aug;50(8):1714-9
11473029
Br J Nutr. 2000 Nov;84 Suppl 1:S39-46
11242445
J Nutr. 2004 Apr;134(4):996S-1002S
15051860
Pancreas. 1992;7(6):698-704
1448457
Br J Nutr. 2000 Oct;84(4):405-15
11103211
Physiol Behav. 2008 Jan 28;93(1-2):379-87
17964616
Endocrinology. 2003 Jul;144(7):2765-7
12810528
J Clin Endocrinol Metab. 2004 Mar;89(3):1319-24
15001628
Am J Clin Nutr. 2009 Apr;89(4):1068-77
19244369
Mol Genet Metab. 2007 Sep-Oct;92(1-2):176-8
17644019
Obes Res. 1997 Jul;5(4):381-4
9285848
Eur J Pediatr. 1996 Jul;155 Suppl 1:S115-20
8828625
Br J Nutr. 2003 Feb;89(2):239-48
12575908
Appetite. 2001 Apr;36(2):157-63
11237351
Am J Clin Nutr. 2008 Jun;87(6):1602-5
18541546