Antiviral drug resistance: mechanisms and clinical implications.
Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.
Strasfeld
Lynne
L
Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, mail code L457, Portland, OR 97239, USA. strasfel@ohsu.edu
Chou
Sunwen
S
D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D006801:Humans; D016867:Immunocompromised Host; D009369:Neoplasms / Q000150:complications; D014180:Transplantation; D014777:Virus Diseases / Q000188:drug therapy* / Q000821:virology*; D014780:Viruses / Q000187:drug effects* / Q000302:isolation & purification
D000998:Antiviral Agents
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