Aminoheterocycles as synthons for combinatorial Biginelli reactions.
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.
Ryabukhin
Sergey V
SV
Enamine Ltd, 23 A. Matrosova St., Kyiv, 01103, Ukraine. Ryabukhin@mail.enamine.net
Plaskon
Andrey S
AS
Boron
Sergey Yu
SY
Volochnyuk
Dmitriy M
DM
Tolmachev
Andrey A
AA
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry
D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries
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