A case of explosive progression of hepatocellular carcinoma in a patient with common variable immunodeficiency (CVID).
OBJECTIVE
While it is well known that patients with common variable immunodeficiency (CVID) are predisposed to various malignancies, primarily non-Hodgkin's lymphoma and gastric carcinomas, to our knowledge no cases of hepatocellular carcinoma have been reported in the absence of preexisting liver disease.


RESULTS
We report a 50-year-old male patient with CVID with a B- and T-cell deficiency. The patient was on prophylactic intravenous gammaglobulin and had received several years earlier a course of rituximab for an autoimmune disorder. He had no history of hepatitis. The patient developed a rapidly progressing hepatocellular carcinoma within 3 to 4 weeks.


CONCLUSIONS
Although patients with CVID are predisposed to malignancies such as lymphoma and adenocarcinoma of the stomach, rapidly progressive hepatocellular carcinoma in the absence of any preexisting liver disease has not been described.
Gandhi
Kaushang
K
Department of Internal Medicine, Westchester Medical Center/New York Medical College, New York, USA. kaushanggandhi@yahoo.com
Parikh
Purvi
P
Aronow
Wilbert S
WS
Desai
Harit
H
Amin
Harshad
H
Sharma
Mala
M
Rubinstein
Arye
A
D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D007155:Immunologic Factors
Curr Opin Genet Dev. 2007 Jun;17(3):201-12
17467261
Am J Hematol. 2002 Mar;69(3):171-8
11891803
Lancet. 2008 Aug 9;372(9637):489-502
18692715
J Clin Immunol. 2007 May;27(3):308-16
17510807
Ann Allergy Asthma Immunol. 2005 May;94(5 Suppl 1):S1-63
15945566
Q J Med. 1993 Jan;86(1):31-42
8438047
Eur J Pediatr. 1996 Jul;155(7):532-4
8831072
Clin Exp Immunol. 2002 Dec;130(3):495-500
12452841
J Clin Immunol. 1987 Jul;7(4):294-9
3611296
Clin Exp Med. 2004 Apr;3(4):211-7
15103511
Hepatol Res. 2008 Apr;38(4):415-20
18021227
Lancet. 1985 Feb 2;1(8423):263-6
2857327
Clin Immunol. 1999 Dec;93(3):190-7
10600329
Clin Immunol. 1999 Jul;92(1):34-48
10413651
Int Arch Allergy Immunol. 2009;150(4):311-24
19571563
J Intern Med. 1996 Aug;240(2):99-102
8810936