title: Synthesis, structure and reactivity of azosalophen complexes of vanadium(IV): studies on cytotoxic properties.
abstract: The free ligands, 2-{(o-hydroxyaryl)azo}-1-N-salicylidene phenylamine, H(2)L [where H(2)L = RC(6)H(4)N=NC(6)H(4)N=CH-C(6)H(4)OHR = p-H for H(2)L(1), p-Me for H(2)L(2) and p-Cl for H(2)L(3)], were prepared by the condensation of salicylaldehyde with 2-{(o-hydroxy aryl)azo} aniline. Reaction of H(2)L with VOSO(4) afforded the oxovanadium complex, (L)V(O)(H(2)O). The (L(1))V(O)(H(2)O) complex displays two reversible responses at 0.7 V and -0.65 V vs. SCE in cyclic voltammetry. Catalytic activity of (L(1))V(O)(H(2)O) toward H(2)O(2) induced oxidation of organic thioethers to sulfoxide and sulfones have been examined. The cytotoxicity of (L(1))V(O)(H(2)O) has also been examined on human lung cancer cells.
authors.affiliation: Department of Chemistry, University of Kalyani, Kalyani. 741235, India.
authors.forename: Poulami
authors.initials: P
authors.lastname: Pattanayak
authors.forename: Jahar Lal
authors.initials: JL
authors.lastname: Pratihar
authors.forename: Debprasad
authors.initials: D
authors.lastname: Patra
authors.forename: Soham
authors.initials: S
authors.lastname: Mitra
authors.forename: Arindam
authors.initials: A
authors.lastname: Bhattacharyya
authors.forename: Hon Man
authors.initials: HM
authors.lastname: Lee
authors.forename: Surajit
authors.initials: S
authors.lastname: Chattopadhyay
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004563:Electrochemistry; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012459:Salicylates / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014639:Vanadium / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D008024:Ligands; D009942:Organometallic Compounds; D012459:Salicylates; D014639:Vanadium; C090416:salophen