title: A murine model of stress controllability attenuates Th2-dominant airway inflammatory responses.
abstract: Epidemiological and experimental studies suggest a positive correlation between chronic respiratory inflammatory disease and the ability to cope with adverse stress. Interactions between neuroendocrine and immune systems are believed to provide insight toward the biological mechanisms of action. The utility of an experimental murine model was employed to investigate the immunological consequences of stress-controllability and ovalbumin-induced airway inflammation. Pre-conditioned uncontrollable stress exacerbated OVA-induced lung histopathological changes that were typical of Th2-predominant inflammatory response along respiratory tissues. Importantly, mice given the ability to exert control over aversive stress attenuated inflammatory responses and reduced lung pathology. This model represents a means of investigating the neuro-immune axis in defining mechanisms of stress and respiratory disease.
authors.affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.
authors.forename: Aniket
authors.initials: A
authors.lastname: Deshmukh
authors.forename: Byung-Jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Xavier
authors.initials: X
authors.lastname: Gonzales
authors.forename: James
authors.initials: J
authors.lastname: Caffrey
authors.forename: Jamboor
authors.initials: J
authors.lastname: Vishwanatha
authors.forename: Harlan P
authors.initials: HP
authors.lastname: Jones
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D018893:Bronchoalveolar Lavage / Q000379:methods; D003583:Cytokinins / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D007249:Inflammation / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000009:adverse effects; D011897:Random Allocation; D012120:Respiration Disorders / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D013315:Stress, Psychological / Q000276:immunology* / Q000503:physiopathology; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology; D013997:Time Factors; D015430:Weight Gain / Q000502:physiology
chemical_list: D015703:Antigens, CD; D003583:Cytokinins; D010047:Ovalbumin
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