title: Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise.
abstract: Green tea's active ingredient, epigallocatechin 3-gallate (EGCG), has gained significant attention among scientists and has been one of the leading plant-derived molecules studied for its potential health benefits. In the present review I summarize the findings from some of the most significant preclinical studies with EGCG in arthritic diseases. The review also addresses the limitations of the dose, pharmacokinetics, and bioavailability of EGCG in experimental animals and findings related to the EGCG-drug interaction. Although these findings provide scientific evidence of the anti-rheumatic activity of EGCG, further preclinical studies are warranted before phase clinical trials could be initiated with confidence for patients with joint diseases.
authors.affiliation: Department of Pharmacology, 2232 Wolfe Hall, College of Pharmacy, 2801 W, Bancroft Street, Toledo, OH 43606, USA. salah.ahmed@utoledo.edu
authors.forename: Salahuddin
authors.initials: S
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D018501:Antirheumatic Agents / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D028241:Camellia sinensis / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D013662:Tea / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D018501:Antirheumatic Agents; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate
references.citation: J Cell Biochem. 2008 Jul 1;104(4):1491-9
references.pmid: 18348186
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4524-9
references.pmid: 10200295
references.citation: Int J Pharm. 2009 Sep 11;379(2):270-7
references.pmid: 19501139
references.citation: Cells Tissues Organs. 2003;174(1-2):34-48
references.pmid: 12784040
references.citation: Biochem Biophys Res Commun. 2009 Feb 20;379(4):1033-7
references.pmid: 19150340
references.citation: Cancer Prev Res (Phila). 2009 Jul;2(7):673-82
references.pmid: 19542190
references.citation: Clin Rev Allergy Immunol. 2005 Jun;28(3):177-86
references.pmid: 16129902
references.citation: Geriatr Gerontol Int. 2009 Mar;9(1):29-40
references.pmid: 19260977
references.citation: Int J Mol Med. 2009 Aug;24(2):197-203
references.pmid: 19578793
references.citation: Ann Rheum Dis. 2006 Jul;65(7):910-2
references.pmid: 16284094
references.citation: Clin Cancer Res. 2003 Aug 15;9(9):3312-9
references.pmid: 12960117
references.citation: Nutr Cancer. 2000;37(1):41-8
references.pmid: 10965518
references.citation: Expert Opin Investig Drugs. 2009 Jul;18(7):957-71
references.pmid: 19505187
references.citation: Free Radic Biol Med. 2002 Oct 15;33(8):1097-105
references.pmid: 12374621
references.citation: Arthritis Rheum. 2000 May;43(5):1094-105
references.pmid: 10817564
references.citation: Cell Transplant. 2009;18(5):505-12
references.pmid: 19775510
references.citation: Leuk Res. 2006 Jun;30(6):707-12
references.pmid: 16325256
references.citation: Arthritis Res Ther. 2009;11(1):203
references.pmid: 19232065
references.citation: J Am Coll Nutr. 2007 Aug;26(4):389S-395S
references.pmid: 17906192
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14692-7
references.pmid: 18796608
references.citation: Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9
references.pmid: 16797629
references.citation: J Nutr. 2002 Mar;132(3):341-6
references.pmid: 11880552
references.citation: Biomaterials. 2003 Dec;24(28):5099-113
references.pmid: 14568426
references.citation: Arthritis Rheum. 2009 May;60(5):1282-93
references.pmid: 19404960
references.citation: Nat Rev Rheumatol. 2009 Oct;5(10):531-41
references.pmid: 19798027
references.citation: Bull NYU Hosp Jt Dis. 2007;65 Suppl 1:S11-5
references.pmid: 17708739
references.citation: Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14
references.pmid: 11994741
references.citation: Arthritis Rheum. 2006 Aug;54(8):2393-401
references.pmid: 16869002
references.citation: Am J Clin Nutr. 2005 Jan;81(1 Suppl):243S-255S
references.pmid: 15640487
references.citation: Arthritis Rheum. 2008 Oct;58(10):3145-56
references.pmid: 18821707
references.citation: Arthritis Rheum. 2000 Mar;43(3):673-82
references.pmid: 10728762
references.citation: Food Chem Toxicol. 2006 May;44(5):636-50
references.pmid: 16387402
references.citation: Arthritis Res Ther. 2009;11(3):R71
references.pmid: 19445683
references.citation: Matrix Biol. 2004 Jun;23(3):163-9
references.pmid: 15296944
references.citation: Tissue Eng Part A. 2010 Feb;16(2):595-603
references.pmid: 19737073
references.citation: Clin Nutr. 2008 Jun;27(3):363-70
references.pmid: 18468736
references.citation: Mol Pharmacol. 2010 Jan;77(1):17-25
references.pmid: 19828731
references.citation: Clin Cancer Res. 2007 Mar 1;13(5):1611-9
references.pmid: 17332308
references.citation: Hum Genet. 2008 Jan;122(6):635-43
references.pmid: 17962980
references.citation: J Am Acad Dermatol. 2001 Mar;44(3):425-32
references.pmid: 11209110
references.citation: Rheumatology (Oxford). 2010 Mar;49(3):467-79
references.pmid: 20032224
references.citation: Bull NYU Hosp Jt Dis. 2008;66(3):244-50
references.pmid: 18937640
references.citation: Am J Clin Nutr. 2005 Jan;81(1 Suppl):230S-242S
references.pmid: 15640486
references.citation: Ann N Y Acad Sci. 2008 Nov;1143:123-50
references.pmid: 19076348
references.citation: Arthritis Rheum. 2001 Jul;44(7):1555-67
references.pmid: 11465707
references.citation: Nat Rev Rheumatol. 2009 Jun;5(6):299-300
references.pmid: 19491907
references.citation: Arthritis Rheum. 2002 Aug;46(8):2079-86
references.pmid: 12209512
references.citation: Cell Biol Int. 2009 Dec 16;34(1):109-16
references.pmid: 19947947
references.citation: Eur J Biochem. 2003 Jun;270(11):2394-403
references.pmid: 12755694
references.citation: Blood. 2009 Jun 4;113(23):5927-37
references.pmid: 19190249
references.citation: Clin Cancer Res. 2005 Jun 15;11(12):4627-33
references.pmid: 15958649
references.citation: J Nutr Sci Vitaminol (Tokyo). 2001 Dec;47(6):402-8
references.pmid: 11922115
references.citation: Oncogene. 2008 Mar 27;27(14):2055-63
references.pmid: 17998943
references.citation: Curr Opin Rheumatol. 2007 May;19(3):308-13
references.pmid: 17414961
references.citation: Immunol Rev. 2008 Jun;223:7-19
references.pmid: 18613827
references.citation: Nat Rev Immunol. 2002 Jul;2(7):527-35
references.pmid: 12094227
references.citation: Mayo Clin Proc. 2007 Jun;82(6):725-32
references.pmid: 17550753
references.citation: J Herb Pharmacother. 2003;3(3):19-32
references.pmid: 15277054
references.citation: Rheumatol Int. 2008 Nov;29(1):23-9
references.pmid: 18496696
references.citation: FEBS Lett. 2007 Apr 3;581(7):1311-6
references.pmid: 17350626
references.citation: Cancer Res. 2009 Mar 1;69(5):1712-6
references.pmid: 19223530
references.citation: Mediators Inflamm. 2008;2008:291808
references.pmid: 19148296
references.citation: J Nutr. 2009 Feb;139(2):264-70
references.pmid: 19074207
references.citation: J Clin Invest. 1996 Feb 1;97(3):761-8
references.pmid: 8609233
references.citation: Anticancer Res. 2005 Jan-Feb;25(1A):397-402
references.pmid: 15816564
references.citation: Org Lett. 2001 Mar 22;3(6):843-6
references.pmid: 11263896
references.citation: J Immunol. 2005 Dec 15;175(12):8337-45
references.pmid: 16339575
references.citation: Br J Nutr. 2009 Mar;101(6):886-94
references.pmid: 18710606
references.citation: Drugs Today (Barc). 2009 Jan;45(1):21-31
references.pmid: 19271029
references.citation: Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):351-4
references.pmid: 9568793
references.citation: Curr Opin Rheumatol. 2006 May;18(3):277-81
references.pmid: 16582692
references.citation: J Altern Complement Med. 2005 Jun;11(3):521-8
references.pmid: 15992239
references.citation: J Clin Oncol. 2009 Aug 10;27(23):3808-14
references.pmid: 19470922
references.citation: J Rheumatol. 2005 Oct;32(10):1958-67
references.pmid: 16206353
references.citation: Prev Chronic Dis. 2009 Apr;6(2):A44
references.pmid: 19288987
references.citation: Arthritis Rheum. 2008 Jul;58(7):2012-8
references.pmid: 18576345
references.citation: Drug Metab Dispos. 1997 Sep;25(9):1045-50
references.pmid: 9311619
references.citation: J Nutr Biochem. 2005 May;16(5):259-66
references.pmid: 15866224
references.citation: J Pharmacol Exp Ther. 2004 Feb;308(2):767-73
references.pmid: 14600251
references.citation: J Nutr. 2008 Nov;138(11):2111-6
references.pmid: 18936206
references.citation: J Orthop Res. 2003 Jan;21(1):102-9
references.pmid: 12507586
references.citation: Int J Pharm. 2010 Apr 15;389(1-2):207-12
references.pmid: 20083179