title: Cytotoxic, radical scavenging and antimicrobial activities of sesquiterpenoids from the Tahitian liverwort Mastigophora diclados (Brid.) Nees (Mastigophoraceae).
abstract: A drimane, (+)-drimenol (1), five known herbertanes, (-)-alpha-herbertenol (2), (-)-herbertenediol (3), mastigophorene A (4), (-)-mastigophorene C (5) and (-)-mastigophorene D (6), a pimarane, (-)-ent-pimara-8(14),15-dien-19-oic acid (7), and two eudesmanolides, (-)-diplophyllolide A (8) and (-)-diplophyllin (9) were isolated from the Tahitian Mastigophora diclados (Brid.) Nees. Herbertane sesquiterpenes (2, 3, 5 and 6) showed cytotoxicity against HL-60 and KB cell lines, radical scavenging activity and antimicrobial activity against Bacillus subtilis. (-)-Diplophyllolide A (8) also exhibited cytotoxicity against HL-60 and KB cell lines.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan.
authors.forename: Ismiarni
authors.initials: I
authors.lastname: Komala
authors.forename: Takuya
authors.initials: T
authors.lastname: Ito
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nagashima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yagi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D018922:HL-60 Cells; D035926:Hepatophyta / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D007624:KB Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D011114:Polynesia; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D003603:Cytotoxins; D016166:Free Radical Scavengers; D010936:Plant Extracts; D012717:Sesquiterpenes
references.citation: Phytomedicine. 1997 Sep;4(3):261-3
references.pmid: 23195486
references.citation: Phytochemistry. 2000 Oct;55(3):247-53
references.pmid: 11142851
references.citation: Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1382-4
references.pmid: 15516770
references.citation: Phytochemistry. 2004 Mar;65(6):623-69
references.pmid: 15016562
references.citation: Phytomedicine. 2007 Aug;14(7-8):486-91
references.pmid: 17336048
references.citation: Z Naturforsch C J Biosci. 2004 Nov-Dec;59(11-12):811-5
references.pmid: 15666539
references.citation: Z Naturforsch B. 1967 Apr;22(4):462-3
references.pmid: 4385299
references.citation: Eur J Pharmacol. 2008 Dec 28;601(1-3):179-85
references.pmid: 18938152
references.citation: J Ethnopharmacol. 2006 Oct 11;107(3):383-8
references.pmid: 16698207
references.citation: Nat Prod Commun. 2009 Oct;4(10):1387-92
references.pmid: 19911577