Assessment of the antimicrobial properties of maggots.
Chronic bacterial colonisation or infection of wound is one of the major factors interfering proper wound healing, especially in diabetic foot ulcers. This study assesses the potential antimicrobial properties of maggots in vitro. This is a prospective randomised experimental study. Complete lysis of methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus and Candida albicans cultures in the area of maggot application was observed 24 hours after application of live maggots in all culture plates and was confirmed by Gram staining. This lysis persisted for more than 5 days after the maggot application. Complete lysis of the bacterial or fungal cultures in the area of maggot application provides convincing evidence for the antimicrobial property of maggots. This effect has a significant implication in management of diabetic foot ulcers and vascular ulcers.
Margolin
Leon
L
Ohio State Medical Center, Columbus, Ohio, USA. leon3087@gmail.com
Gialanella
Philip
P
D000818:Animals; D001424:Bacterial Infections / Q000628:therapy; D001433:Bacteriolysis; D002176:Candida albicans; D002908:Chronic Disease; D003646:Debridement / Q000379:methods; D004175:Diptera; D016983:Enterococcus; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007814:Larva; D009181:Mycoses / Q000382:microbiology / Q000628:therapy; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa; D013211:Staphylococcus aureus; D020713:Vancomycin Resistance; D014945:Wound Healing; D014946:Wound Infection / Q000382:microbiology* / Q000473:pathology / Q000628:therapy*
Lancet. 2000 Dec 9;356(9246):2016
11130559
Clin Orthop Relat Res. 2011 Apr;469(4):920-44
20532712
Arch Phys Med Rehabil. 2001 Sep;82(9):1226-9
11552195
J Tissue Viability. 2000 Jul;10(3):91-4
11299572
Wound Repair Regen. 2002 Jul-Aug;10(4):208-14
12191002
Lancet. 2000 Sep 30;356(9236):1174
11030307
J Spinal Cord Med. 1995 Apr;18(2):71-4
7640976
Hautarzt. 2002 Sep;53(9):608-12
12207265
Prof Nurse. 1999 Feb;14(5):329-33
10205549
Annu Rev Entomol. 2000;45:55-81
10761570