Retrospective comparison of patient outcomes after in-person and telephone results disclosure counseling for BRCA1/2 genetic testing.
Telephone disclosure of BRCA1/2 molecular genetic test results has been proposed as a feasible alternative to traditional in-person results disclosure. The purpose of this study was to investigate the relationship between method of result disclosure with the patient outcome variables of knowledge, cancer worry, cancer risk perception, satisfaction, and cancer screening and prophylactic surgery behaviors. Study participants included 228 women who completed retrospective, self-administered, mailed surveys regarding their pre-test genetic counseling and results disclosure. No significant relationships were found between result disclosure method and the outcome variables investigated. A majority (90%) of individuals who received positive results by telephone returned for follow up visits. Factors which genetic counselors believed influenced their clinical decision to offer telephone disclosure, such as history of breast cancer, a priori risk of genetic mutation and family history of known mutation were not shown to significantly impact the actual disclosure method. This study suggests that telephone results disclosure is clinically appropriate when counselors utilize their clinical judgment to determine which patients are appropriate candidates.
Doughty Rice
Courtney
C
Genetic Counseling Graduate Program, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Ruschman
Jennifer Gamm
JG
Martin
Lisa J
LJ
Manders
Jennifer B
JB
Miller
Erin
E
D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000523:psychology*; D030881:Disclosure / Q000331:legislation & jurisprudence; D005260:Female; D019398:Genes, BRCA1 / Q000502:physiology*; D024522:Genes, BRCA2 / Q000502:physiology; D005817:Genetic Counseling / Q000523:psychology*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007258:Informed Consent / Q000523:psychology; D008297:Male; D018907:Privacy; D012189:Retrospective Studies; D013689:Telephone; D016896:Treatment Outcome
D019313:BRCA1 Protein
N Engl J Med. 1997 May 15;336(20):1409-15
9145677
Health Psychol. 1991;10(4):259-67
1915212
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1893-8
17035396
Am J Med Genet A. 2003 Jan 1;116A(1):11-9
12476445
Am J Med Genet. 1990 Dec;37(4):522-9
2260600
Fam Cancer. 2005;4(4):279-84
16341803
J Genet Couns. 2007 Jun;16(3):241-60
17508274
JAMA. 1996 Jun 26;275(24):1885-92
8648868
Fam Pract. 2001 Apr;18(2):135-40
11264262
Patient Educ Couns. 2006 Dec;64(1-3):96-103
16427245
Psychooncology. 2000 Jan-Feb;9(1):44-56
10668059
Oncol Nurs Forum. 2006 Jan 01;33(1):138-44
16470242
Am J Med Genet A. 2005 Aug 15;137(1):27-35
16007615
Qual Health Res. 2000 Jul;10(4):507-20
11010075
Patient Educ Couns. 1999 May;37(1):3-18
10640115
Genet Med. 2007 Aug;9(8):487-95
17700386
J Clin Oncol. 2002 Mar 15;20(6):1480-90
11896095
J Clin Oncol. 2002 Nov 15;20(22):4485-92
12431973
JAMA. 2008 Mar 19;299(11):1320-34
18349093
Breast J. 2008 Jan-Feb;14(1):3-13
18086272
J Genet Couns. 2009 Oct;18(5):447-63
19462222
J Genet Couns. 2004 Apr;13(2):83-114
15604628
J Genet Couns. 2003 Apr;12(2):171-84
26140847
J Genet Couns. 2000 Feb;9(1):63-71
26141085
J Mol Med (Berl). 2006 Jan;84(1):16-28
16283147
Cancer. 1996 Jun 1;77(11):2318-24
8635102
Am J Med Genet A. 2006 Oct 15;140(20):2198-206
16969872
J Genet Couns. 2000 Feb;9(1):73-82
26141086
Science. 1994 Sep 30;265(5181):2088-90
8091231
Surg Oncol. 2002 May;10(4):183-92
12020673
Science. 1990 Dec 21;250(4988):1684-9
2270482
J Clin Oncol. 2003 Jun 15;21(12):2397-406
12692171