title: Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells.
abstract: We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.
authors.affiliation: Massachusetts Institute of Technology, G. R. Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. ykpark@mit.edu
authors.forename: YongKeun
authors.initials: Y
authors.lastname: Park
authors.forename: Monica
authors.initials: M
authors.lastname: Diez-Silva
authors.forename: Dan
authors.initials: D
authors.lastname: Fu
authors.forename: Gabriel
authors.initials: G
authors.lastname: Popescu
authors.forename: Wonshik
authors.initials: W
authors.lastname: Choi
authors.forename: Ishan
authors.initials: I
authors.lastname: Barman
authors.forename: Subra
authors.initials: S
authors.lastname: Suresh
authors.forename: Michael S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D004912:Erythrocytes / Q000469:parasitology* / Q000473:pathology*; D006801:Humans; D008027:Light; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D010963:Plasmodium falciparum / Q000472:pathogenicity / Q000502:physiology*; D012016:Reference Values; D012542:Scattering, Radiation
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