title: [Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain].
abstract: BACKGROUND
  LRRK2 mutations have been described as a common cause of Parkinson's disease (PD) in patients from northern Spain. Here we investigated the prevalence of these mutations in a cohort of Spanish PD patients (n = 96) from Extremadura, a region in southwestern Spain.
  
  
  METHODS
  To evaluate the rate of the G2019S and R1441G/C/H LRKK2 mutations in PD patients and healthy controls (n = 163).
  
  
  RESULTS
  Here we show that the G2019S mutation is present at a low prevalence in our Spanish cohort, while the R1441G/C/H mutation, which has been reported to be common in northern Spain, was not observed in the PD patients or in the controls.
  
  
  CONCLUSIONS
  LRRK2 mutations do not appear to be a common cause of Parkinson's disease in Extremadura, Spain.
authors.affiliation: Departamento de Enfermería, Universidad de Extremadura, Facultad de Medicina, Badajoz, España. jmmorang@unex.es
authors.forename: José M
authors.initials: JM
authors.lastname: Morán
authors.forename: Fernando
authors.initials: F
authors.lastname: Castellanos-Pinedo
authors.forename: Ignacio
authors.initials: I
authors.lastname: Casado-Naranjo
authors.forename: Carmen
authors.initials: C
authors.lastname: Durán-Herrera
authors.forename: José M
authors.initials: JM
authors.lastname: Ramírez-Moreno
authors.forename: Montserrat
authors.initials: M
authors.lastname: Gómez
authors.forename: José Martín
authors.initials: JM
authors.lastname: Zurdo-Hernández
authors.forename: Elisabet
authors.initials: E
authors.lastname: Fuentes
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Ortiz-Ortiz
authors.forename: Antonio D
authors.initials: AD
authors.lastname: Moreno
authors.forename: Rosa A
authors.initials: RA
authors.lastname: González-Polo
authors.forename: Mireia
authors.initials: M
authors.lastname: Niso-Santano
authors.forename: José M
authors.initials: JM
authors.lastname: Bravo-Sanpedro
authors.forename: Jordi
authors.initials: J
authors.lastname: Pérez-Tur
authors.forename: Luz M
authors.initials: LM
authors.lastname: Ruiz-Mesa
authors.forename: José M
authors.initials: JM
authors.lastname: Fuentes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003062:Codon; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D013030:Spain
chemical_list: D003062:Codon; D005819:Genetic Markers; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases