title: Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract.
abstract: In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
authors.affiliation: Departmento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. marley@ipk.sld.cu
authors.forename: Marley García
authors.initials: MG
authors.lastname: Parra
authors.forename: Lianet Monzote
authors.initials: LM
authors.lastname: Fidalgo
authors.forename: Judith Mendiola
authors.initials: JM
authors.lastname: Martinez
authors.forename: Ana Margarita Montalvo
authors.initials: AM
authors.lastname: Alvarez
authors.forename: Olga Valdés
authors.initials: OV
authors.lastname: Iglesias
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004447:Echinodermata / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000981:Antiprotozoal Agents