title: Yeast as a model to study mitochondrial mechanisms in ageing.
abstract: Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria-nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms.
authors.affiliation: Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Mario H
authors.initials: MH
authors.lastname: Barros
authors.forename: Fernanda M
authors.initials: FM
authors.lastname: da Cunha
authors.forename: Graciele A
authors.initials: GA
authors.lastname: Oliveira
authors.forename: Erich B
authors.initials: EB
authors.lastname: Tahara
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Kowaltowski
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D001343:Autophagy; D031204:Caloric Restriction; D002467:Cell Nucleus / Q000378:metabolism; D019069:Cell Respiration; D004271:DNA, Fungal / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species