title: 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.
abstract: The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.
authors.affiliation: Fonds de la Recherche Scientifique (FNRS), Laboratoire de Psychologie Médicale, Université Libre de Bruxelles, Belgium. mnoro@ulb.ac.be
authors.forename: Magali
authors.initials: M
authors.lastname: Noro
authors.forename: Irina
authors.initials: I
authors.lastname: Antonijevic
authors.forename: Carlos
authors.initials: C
authors.lastname: Forray
authors.forename: Siegfried
authors.initials: S
authors.lastname: Kasper
authors.forename: Neslihan Aygun
authors.initials: NA
authors.lastname: Kocabas
authors.forename: Yves
authors.initials: Y
authors.lastname: Lecrubier
authors.forename: Sylvie
authors.initials: S
authors.lastname: Linotte
authors.forename: Julien
authors.initials: J
authors.lastname: Mendlewicz
authors.forename: Stuart
authors.initials: S
authors.lastname: Montgomery
authors.forename: Lenore
authors.initials: L
authors.lastname: Snyder
authors.forename: Daniel
authors.initials: D
authors.lastname: Souery
authors.forename: Paul
authors.initials: P
authors.lastname: Verbanck
authors.forename: Joseph
authors.initials: J
authors.lastname: Zohar
authors.forename: Isabelle
authors.initials: I
authors.lastname: Massat
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D004351:Drug Resistance; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D044402:Receptor, Serotonin, 5-HT2A; D044282:Receptor, Serotonin, 5-HT1A