New insights into the regulation of the actin cytoskeleton by tropomyosin.
The actin cytoskeleton is regulated by a variety of actin-binding proteins including those constituting the tropomyosin family. Tropomyosins are coiled-coil dimers that bind along the length of actin filaments. In muscles, tropomyosin regulates the interaction of actin-containing thin filaments with myosin-containing thick filaments to allow contraction. In nonmuscle cells where multiple tropomyosin isoforms are expressed, tropomyosins participate in a number of cellular events involving the cytoskeleton. This chapter reviews the current state of the literature regarding tropomyosin structure and function and discusses the evidence that tropomyosins play a role in regulating actin assembly.
Wang
C-L Albert
CL
Boston Biomedical Research Institute, Watertown, MA, USA.
Coluccio
Lynne M
LM
D000199:Actins / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D020409:Molecular Motor Proteins / Q000502:physiology; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000502:physiology; D009218:Myosins / Q000502:physiology; D009362:Neoplasm Metastasis / Q000503:physiopathology; D010766:Phosphorylation; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D014335:Tropomyosin / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D000199:Actins; D002148:Calmodulin-Binding Proteins; D020409:Molecular Motor Proteins; D020033:Protein Isoforms; D014335:Tropomyosin; D009218:Myosins
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