[The dose-response of unstable chromosome exchanges in lymphocytes of cancer patients undergone whole-body fractionated gamma-rays exposure at the total dose 1.15 Gy].
The dose-response of unstable chromosome exchanges (UCE) in lymphocytes of 4 cancer patients undergone whole-body fractionated gamma-rays exposure (at the daily dose of 0.115 Gy up to the total dose 1.15 Gy) was compared with corresponding dose-response for lymphocytes of the same patients, irradiated in vitro at the same dose range. In vivo irradiation yielded lower frequency of UCE on the dose unit than in vitro irradiation. It was shown that the in vivo dose-response curve gives more adequate dose estimation than in vitro one. This curve could be used for reconstruction of absorbed dose in the cases of analogous character of in-controlled irradiation of people.
Semenov
A V
AV
Vorobtsova
I E
IE
Zharinov
G M
GM
D000293:Adolescent; D043171:Chromosomal Instability / Q000235:genetics*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000627:therapeutic use*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy*; D014916:Whole-Body Irradiation / Q000592:standards; D055815:Young Adult