title: Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians.
abstract: The transcription factor glioma-associated oncogene homolog 1 (GLI1) has a central function in gastrointestinal tract development and homeostasis. A non-synonymous single-nucleotide polymorphism (SNP) (rs2228226; Q1100E) in GLI1, which impairs GLI1 function in vitro, has been proposed as a risk factor for inflammatory bowel disease (IBD). In this study, we assessed the cumulative evidence for association of GLI1 with IBD. New genotype data for rs2228226 from New Zealand (907 controls, 990 IBD patients) and Belgian Caucasian case-control data sets (312 controls, 1214 IBD patients) were combined with data from the National Institute of Diabetes and Digestive and Kidney Diseases and three previously studied Caucasian case-control data sets. Meta-analysis of rs2228226 did not detect any association with ulcerative colitis (UC) (P=0.09, odds ratio (OR)=1.07, 95% confidence interval (CI)=0.92-1.24), Crohn's disease (CD) (P=0.29, OR=1.06, 95% CI=0.93-1.21) or overall IBD (P=0.15, OR=1.05, 95% CI=0.92-1.19). Our analyses of rs2228226 suggest that GLI1 is not a significant risk factor for IBD in Caucasians.
authors.affiliation: Department of Pathology, University of Otago, Christchurch, New Zealand.
authors.forename: R W
authors.initials: RW
authors.lastname: Bentley
authors.forename: I
authors.initials: I
authors.lastname: Cleynen
authors.forename: R B
authors.initials: RB
authors.lastname: Gearry
authors.forename: M L
authors.initials: ML
authors.lastname: Barclay
authors.forename: P
authors.initials: P
authors.lastname: Rutgeerts
authors.forename: T R
authors.initials: TR
authors.lastname: Merriman
authors.forename: M
authors.initials: M
authors.lastname: Ferrante
authors.forename: R L
authors.initials: RL
authors.lastname: Roberts
authors.forename: S
authors.initials: S
authors.lastname: Vermeire
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics*; D044465:White People / Q000235:genetics*; D055815:Young Adult; D000071676:Zinc Finger Protein GLI1
chemical_list: C400551:GLI1 protein, human; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1