[Endocytosis of cholinoreceptors in the mechanism of depression of cholinosensitivity in Helix lucorum neurons in a cellular model of habituation].
Inhibitors of dynamin-dependent endocytosis (dynamin inhibitory peptide and dynasore) and inhibitors of tubulin (colchicine and vinblastine) decrease the depression of acetylcholine-induced inward current in command neurons of Helix defensive behavior under conditions of rhythmical local applications of acetylcholine to a neuron soma in a cellular model of habituation. Mathematical model which allows for the possibility of different localizations of receptors in a neuron and characteristics of receptor travel makes it possible to analyze the dependence of the current depression on some intracellular processes. We suggest that the cholinosensitivity depression of extrasynaptic membrane zones in command neurons of Helix defensive behavior in the cellular model of habituation under study is associated with dynamin-dependent endocytosis of cholinoreceptors with involvement of cytoskeleton microtubules.
Makhnovskiĭ
D A
DA
Tret'iakova
M S
MS
Murzina
G B
GB
Pivovarov
A S
AS
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D034281:Dynamins / Q000037:antagonists & inhibitors; D004705:Endocytosis; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D006372:Helix, Snails / Q000502:physiology*; D006835:Hydrazones / Q000494:pharmacology; D036881:Long-Term Synaptic Depression; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D050257:Tubulin Modulators / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
D006835:Hydrazones; C511794:N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide; D011950:Receptors, Cholinergic; D050257:Tubulin Modulators; D014747:Vinblastine; D034281:Dynamins; D003078:Colchicine