title: Excavatoids L-N, new 12-hydroxybriaranes from the cultured octocoral Briareum excavatum (Briareidae).
abstract: Three new 12-hydroxybriarane diterpenoids, excavatoids L-N (1-3), have been isolated from the cultured octocoral Briareum excavatum. The structures of new briaranes 1-3 were elucidated by the interpretations of spectroscopic methods. Excavatoid L (1) displayed moderate inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
authors.affiliation: National Museum of Marine Biology & Aquarium (NMMBA), Checheng, Pingtung 944, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Bo-Yuan
authors.initials: BY
authors.lastname: Chen
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: I-Chu
authors.initials: IC
authors.lastname: Huang
authors.forename: Mei-Ru
authors.initials: MR
authors.lastname: Lin
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Jan-Jung
authors.initials: JJ
authors.lastname: Li
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects*; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001688:Biological Products; D004224:Diterpenes; C551755:excavatoid L; C551756:excavatoid M; C551757:excavatoid N; D013481:Superoxides; D010196:Pancreatic Elastase