title: [Treatment of adult patients with metastatic sarcoma: current shift in concepts].
abstract: We describe herein the current concepts tested in clinical trials dedicated to patients with metastatic soft tissue sarcomas: identify predictive factors under anthracyclin-based regimens, identify patients beneficing from polychemotherapy, benefit of maintenance treatment, use of non-progression rate rather than response rate for selecting new drugs, histology-tailored or biological target-tailored second-line treatment.
authors.affiliation: Centre Oscar-Lambret, Département de cancérologie générale, 3, rue F.-Combemale, 59020 Lille, France.
authors.forename: N
authors.initials: N
authors.lastname: Penel
authors.forename: F
authors.initials: F
authors.lastname: Watelle
authors.forename: M
authors.initials: M
authors.lastname: Vanhuyse
authors.forename: A
authors.initials: A
authors.lastname: Adenis
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: C515074:ridaforolimus; D004317:Doxorubicin; D020123:Sirolimus