title: Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury.
abstract: Toll-like receptors (TLRs) play a key role in innate immune defenses. After activation by foreign pathogens or host-derived molecules, TLRs signal via overlapping or distinct signaling cascades and eventually induce numerous genes involved in a variety of cellular responses. A growing body of evidence suggests that TLR signaling also plays an important role in cardiac ischemia/reperfusion injury. We review our current understanding of the TLR signaling pathways and their roles in the pathophysiology of cardiac ischemia/reperfusion injury, as well as discuss several mechanisms for TLR activation and regulation.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Abarbanell
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Herrmann
authors.forename: Brent R
authors.initials: BR
authors.lastname: Weil
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Poynter
authors.forename: Mariuxi C
authors.initials: MC
authors.lastname: Manukyan
authors.forename: Paul R
authors.initials: PR
authors.lastname: Crisostomo
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Meldrum
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D015427:Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism*
chemical_list: D051193:Toll-Like Receptors