title: An analysis of genetic changes during the divergence of Drosophila species.
abstract: BACKGROUND
  It has been long appreciated that speciation involves changes in body plans and establishes genetic, reproductive, developmental and behavioral incompatibilities between populations. However, little is still known about the genetic components involved in these changes or the sequence and scale of events that lead to the differentiation of species.
  
  
  RESULTS
  In this paper, we investigated the genetic changes in three closely related species of Drosophila by making pair-wise comparisons of their genomes. We focused our analysis on the modern relatives of the alleles likely to be segregating in pre-historic populations at the time or after the ancestor of D. simulans became separated from the ancestor of D. melanogaster. Some of these genes were previously implicated in the genetics of reproduction and behavior while the biological functions of others are not yet clear.
  
  
  CONCLUSIONS
  Together these results identify different classes of genes that might have participated in the beginning of segregation of these species millions of years ago in Africa.
authors.affiliation: Department of Biology, Case Western Reserve University, Cleveland, Ohio, United States of America. rui.sousaneves@case.edu
authors.forename: Rui
authors.initials: R
authors.lastname: Sousa-Neves
authors.forename: Alexandre
authors.initials: A
authors.lastname: Rosas
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002875:Chromosomes / Q000235:genetics; D003625:Data Collection; D004330:Drosophila / Q000235:genetics*; D017344:Genes, Insect / Q000235:genetics; D014644:Genetic Variation; D017711:Nonlinear Dynamics; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
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