title: [Long-term remission of malignant melanoma stage IV after antigen-specific immunotherapy].
abstract: This case report describes the clinical course of a patient with progressing metastatic melanoma (M1a) under standard chemotherapy, followed by long-term partial remission of disease under treatment with experimental, specific immunotherapy. Detectable specific immune responses demonstrate the correlation between continued tumor regression and the administered specific immunotherapy.
authors.affiliation: Klinik für Onkologie und Hämatologie, Krankenhaus Nordwest, Frankfurt/Main, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Neumann
authors.forename: Julia
authors.initials: J
authors.lastname: Karbach
authors.forename: Akin
authors.initials: A
authors.lastname: Atmaca
authors.forename: Elke
authors.initials: E
authors.lastname: Jäger
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D000971:Antineoplastic Combined Chemotherapy Protocols; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D019496:Cancer Vaccines / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D018450:Disease Progression; D000939:Epitopes / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D007271:Injections, Intradermal; D007866:Leg; D008207:Lymphatic Metastasis / Q000473:pathology; D008545:Melanoma / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology*; D009367:Neoplasm Staging; D010166:Palliative Care; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D017741:Survivors
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D000939:Epitopes; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins
references.citation: Int J Cancer. 2000 May 15;86(4):538-47
references.pmid: 10797269
references.citation: Cancer Sci. 2009 Nov;100(11):2014-21
references.pmid: 19719775
references.citation: J Exp Med. 1996 Mar 1;183(3):725-9
references.pmid: 8642276
references.citation: Int J Cancer. 1996 Jul 3;67(1):54-62
references.pmid: 8690525
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14453-8
references.pmid: 16984998