Cerebrospinal fluid changes in the excitatory amino acids concentration caused by the standard treatment of acute lymphoblastic leukaemia in children do not correlate with their later cognitive functioning.
The aim of this study was to ascertain whether changes in the concentrations of cerebrospinal fluid excitatory amino acids (EAAs) contribute to neurotoxicity of the standard acute lymphoblastic leukaemia (ALL) treatment protocols. We found a statistically significant increase in glutamate and aspartate in 12 ALL patients during their treatment. Cognitive functioning was examined in all patients at an average of 3.7 years after the disease diagnosis. Importantly, the levels of EAAs during the therapy were not correlated with the results of the cognitive test. This study suggests that standard ALL treatment-induced neurotoxicity may not lead to persistent neurocognitive deficits.
Protas
P T
PT
Departament of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland. piotrp15@wp.pl
Muszynska-Roslan
K
K
Holownia
A
A
Grabowska
A
A
Krawczuk-Rybak
M
M
Braszko
J J
JJ
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D018846:Excitatory Amino Acids / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy*
D018846:Excitatory Amino Acids