Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: synthesis of 4-aryl-2-quinolinones.
A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp(2))-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the presence of a catalytic amount of PdCl(2) and Cu(OAc)(2) under an O(2) atmosphere, providing practical access to a range of variously substituted 4-aryl-2-quinolinones.
Inamoto
Kiyofumi
K
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. inamoto@mail.pharm.tohoku.ac.jp
Saito
Tadataka
T
Hiroya
Kou
K
Doi
Takayuki
T
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D003500:Cyclization; D010100:Oxygen; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis*
D000577:Amides; D015363:Quinolones; D010165:Palladium; D003300:Copper; D010100:Oxygen