Mechanisms governing the control of mRNA translation.
The translation of cellular mRNA to protein is a tightly controlled process often deregulated in diseases such as cancer. Furthering our understanding of mRNA structural elements and the intracellular proteins and signaling pathways that affect protein expression is crucial in the development of new therapies. In this review, we discuss the current state-of-the-art of detecting and determining the role of mRNA sequence elements in regulating the initiation of mRNA translation and the therapeutic strategies that exploit this knowledge to treat disease.
Livingstone
Mark
M
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, QC H3A 1A3, Canada.
Atas
Evrim
E
Meller
Amit
A
Sonenberg
Nahum
N
D000818:Animals; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics*
D012333:RNA, Messenger