title: The inherited genetics of ovarian and endometrial cancer.
abstract: Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40,000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22,000 new diagnoses and 15,000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications.
authors.affiliation: EGA Institute for Women's Health, Gynaecological Cancer Research Laboratories, University College London, London, UK. s.gayther@ucl.ac.uk
authors.forename: Simon A
authors.initials: SA
authors.lastname: Gayther
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics*; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D019683:Penetrance; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
references.citation: Lancet Oncol. 2009 Apr;10(4):327-40
references.pmid: 19282241
references.citation: J Natl Cancer Inst. 2010 Feb 3;102(3):193-201
references.pmid: 20028993
references.citation: Clin Cancer Res. 2004 Apr 1;10(7):2473-81
references.pmid: 15073127
references.citation: Cancer Res. 2003 Jan 15;63(2):417-23
references.pmid: 12543797
references.citation: Fam Cancer. 2001;1(1):57-60
references.pmid: 14574017
references.citation: Gynecol Oncol. 2006 May;101(2):238-43
references.pmid: 16360201
references.citation: Gastroenterology. 2004 Jul;127(1):17-25
references.pmid: 15236168
references.citation: N Engl J Med. 2008 Jun 26;358(26):2796-803
references.pmid: 18579814
references.citation: Future Oncol. 2006 Apr;2(2):257-74
references.pmid: 16563094
references.citation: Int J Cancer. 1999 Apr 12;81(2):214-8
references.pmid: 10188721
references.citation: Am J Hum Genet. 2007 Dec;81(6):1186-200
references.pmid: 17999359
references.citation: Am J Obstet Gynecol. 1998 Apr;178(4):670-7
references.pmid: 9579428
references.citation: Br J Obstet Gynaecol. 1998 May;105(5):493-9
references.pmid: 9637117
references.citation: N Engl J Med. 1998 Aug 20;339(8):511-8
references.pmid: 9709044
references.citation: Hered Cancer Clin Pract. 2009 Aug 23;7(1):14
references.pmid: 19698169
references.citation: J Med Genet. 2000 Nov;37(11):828-30
references.pmid: 11073535
references.citation: J Clin Oncol. 2007 Nov 20;25(33):5158-64
references.pmid: 17925543
references.citation: Fam Cancer. 2005;4(3):233-7
references.pmid: 16136383
references.citation: N Engl J Med. 2009 Jul 9;361(2):123-34
references.pmid: 19553641
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4240-5
references.pmid: 10200246
references.citation: Mol Oncol. 2009 Apr;3(2):171-81
references.pmid: 19383379
references.citation: Cancer Res. 2007 Apr 1;67(7):3027-35
references.pmid: 17409409
references.citation: Eur J Cancer Prev. 2009 Apr;18(2):95-9
references.pmid: 19337055
references.citation: Am J Hum Genet. 1999 Oct;65(4):1021-9
references.pmid: 10486320
references.citation: N Engl J Med. 2000 Jul 13;343(2):78-85
references.pmid: 10891514
references.citation: Hum Mol Genet. 1997 Jan;6(1):105-10
references.pmid: 9002677
references.citation: Br J Cancer. 2008 Jan 29;98(2):282-8
references.pmid: 18219286
references.citation: J Clin Oncol. 2005 Nov 1;23(31):7919-26
references.pmid: 16258091
references.citation: Expert Rev Anticancer Ther. 2008 Jul;8(7):1159-67
references.pmid: 18588460
references.citation: Cancer Epidemiol Biomarkers Prev. 1996 Jun;5(6):411-7
references.pmid: 8781735
references.citation: N Engl J Med. 2006 Jan 19;354(3):261-9
references.pmid: 16421367
references.citation: N Engl J Med. 2005 May 5;352(18):1851-60
references.pmid: 15872200
references.citation: Cancer Res. 2009 Mar 15;69(6):2349-57
references.pmid: 19276375
references.citation: Hum Mol Genet. 2008 Oct 15;17(R2):R109-15
references.pmid: 18852198
references.citation: Nat Genet. 2009 Sep;41(9):996-1000
references.pmid: 19648919
references.citation: J Clin Oncol. 2003 Dec 1;21(23):4364-70
references.pmid: 14645426
references.citation: Cancer Control. 2009 Jan;16(1):14-22
references.pmid: 19078925
references.citation: Adv Exp Med Biol. 2008;622:53-67
references.pmid: 18546618
references.citation: J Med Genet. 2008 Jul;45(7):425-31
references.pmid: 18413374
references.citation: Gastroenterology. 2005 Aug;129(2):415-21
references.pmid: 16083698
references.citation: Hum Mutat. 2007 Dec;28(12):1207-15
references.pmid: 17688236
references.citation: Int J Cancer. 2008 Jul 15;123(2):444-449
references.pmid: 18398828
references.citation: Gastroenterology. 1999 Jun;116(6):1453-6
references.pmid: 10348829
references.citation: Gynecol Oncol. 2005 Jan;96(1):21-4
references.pmid: 15589575
references.citation: Gastroenterology. 1996 Apr;110(4):1020-7
references.pmid: 8612988
references.citation: Am J Hum Genet. 2008 Apr;82(4):937-48
references.pmid: 18355772
references.citation: Nat Genet. 1997 Apr;15(4):356-62
references.pmid: 9090379
references.citation: N Engl J Med. 1996 Nov 7;335(19):1413-6
references.pmid: 8875917
references.citation: Am J Hum Genet. 1998 Mar;62(3):676-89
references.pmid: 9497246
references.citation: Mol Oncol. 2009 Apr;3(2):138-50
references.pmid: 19383375
references.citation: Am J Epidemiol. 1992 Jan 1;135(1):35-40
references.pmid: 1736658
references.citation: Am J Hum Genet. 2003 May;72(5):1117-30
references.pmid: 12677558
references.citation: J Clin Oncol. 2001 Oct 15;19(20):4074-80
references.pmid: 11600610
references.citation: Int J Gynecol Cancer. 2007 Jul-Aug;17(4):789-93
references.pmid: 17343610
references.citation: J Clin Oncol. 2005 Jul 20;23(21):4609-16
references.pmid: 15837969