title: [An overwhelming post-splenectomy infection with toxic shock syndrome by group B Streptococcus].
abstract: Patients receiving splenectomy are at risk of a fatal fulminant infection called overwhelming post-splenectomy infection (OPSI). Here we report a rare case of toxic shock syndrome (TSS) evoked by group B streptococcus (GBS) in an asplenic young woman, which we considered a case of OPSI. A 34-year old woman consulted our hospital complaining of vomiting, diarrhea and fever that developed early in the morning. As the physical examination and routine laboratory tests did not disclose any serious abnormalities, she returned home after symptomatic treatment under a provisional diagnosis of acute enterocolitis. However, the next morning, she was transferred to the hospital complicated by acute renal failure, severe liver damage, respiratory insufficiency, disseminated intravascular coagulation and hypotension. She was admitted to ICU and treated with intravenous antibiotics, frequent transfusions of platelet concentrates, hemodialysis, and non-invasive positive pressure ventilation. Blood cultures grew gram-positive cocci, which later proved to be Streptococcus agalactiae (GBS). We diagnosed the patient with TSS due to GBS. Organ damage and symptoms improved gradually with intensive treatment, she was discharged from the hospital 26 days after admission. Although cases of TSS due to GBS are very rare, we must be aware of the potential risk of OPSI in a splenectomized patient.
authors.affiliation: Division of Hematology and Immunology, Department of Internal Medicine, Ohtsu Red Cross Hospital.
authors.forename: Dai
authors.initials: D
authors.lastname: Chihara
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Gaku
authors.initials: G
authors.lastname: Murakami
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Takeoka
authors.forename: Tatsuharu
authors.initials: T
authors.lastname: Ohno
mesh_terms: D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006801:Humans; D011183:Postoperative Complications; D012772:Shock, Septic / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D013156:Splenectomy; D013290:Streptococcal Infections; D013292:Streptococcus agalactiae / Q000302:isolation & purification*