title: Genome-wide association study identifies five new breast cancer susceptibility loci.
abstract: Breast cancer is the most common cancer in women in developed countries. To identify common breast cancer susceptibility alleles, we conducted a genome-wide association study in which 582,886 SNPs were genotyped in 3,659 cases with a family history of the disease and 4,897 controls. Promising associations were evaluated in a second stage, comprising 12,576 cases and 12,223 controls. We identified five new susceptibility loci, on chromosomes 9, 10 and 11 (P = 4.6 x 10(-7) to P = 3.2 x 10(-15)). We also identified SNPs in the 6q25.1 (rs3757318, P = 2.9 x 10(-6)), 8q24 (rs1562430, P = 5.8 x 10(-7)) and LSP1 (rs909116, P = 7.3 x 10(-7)) regions that showed more significant association with risk than those reported previously. Previously identified breast cancer susceptibility loci were also found to show larger effect sizes in this study of familial breast cancer cases than in previous population-based studies, consistent with polygenic susceptibility to the disease.
authors.affiliation: Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Turnbull
authors.forename: Shahana
authors.initials: S
authors.lastname: Ahmed
authors.forename: Jonathan
authors.initials: J
authors.lastname: Morrison
authors.forename: David
authors.initials: D
authors.lastname: Pernet
authors.forename: Anthony
authors.initials: A
authors.lastname: Renwick
authors.forename: Mel
authors.initials: M
authors.lastname: Maranian
authors.forename: Sheila
authors.initials: S
authors.lastname: Seal
authors.forename: Maya
authors.initials: M
authors.lastname: Ghoussaini
authors.forename: Sarah
authors.initials: S
authors.lastname: Hines
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Healey
authors.forename: Deborah
authors.initials: D
authors.lastname: Hughes
authors.forename: Margaret
authors.initials: M
authors.lastname: Warren-Perry
authors.forename: William
authors.initials: W
authors.lastname: Tapper
authors.forename: Diana
authors.initials: D
authors.lastname: Eccles
authors.forename: D Gareth
authors.initials: DG
authors.lastname: Evans
authors.forename: Maartje
authors.initials: M
authors.lastname: Hooning
authors.forename: Mieke
authors.initials: M
authors.lastname: Schutte
authors.forename: Ans
authors.initials: A
authors.lastname: van den Ouweland
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
authors.forename: Gillian
authors.initials: G
authors.lastname: Ross
authors.forename: Cordelia
authors.initials: C
authors.lastname: Langford
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stratton
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.forename: Nazneen
authors.initials: N
authors.lastname: Rahman
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide
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