title: Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging.
abstract: A paramagnetic manganese complex of a fluorescein-based probe affords a dual-modality zinc sensor featuring an improved fluorescence dynamic range and an MRI readout.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Youngmin
authors.initials: Y
authors.lastname: You
authors.forename: Elisa
authors.initials: E
authors.lastname: Tomat
authors.forename: Kevin
authors.initials: K
authors.lastname: Hwang
authors.forename: Tatjana
authors.initials: T
authors.lastname: Atanasijevic
authors.forename: Wonwoo
authors.initials: W
authors.lastname: Nam
authors.forename: Alan P
authors.initials: AP
authors.lastname: Jasanoff
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard
mesh_terms: D005452:Fluoresceins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D008856:Microscopy, Fluorescence / Q000379:methods*; D015032:Zinc / Q000032:analysis*
chemical_list: D005452:Fluoresceins; D005456:Fluorescent Dyes; D008345:Manganese; D015032:Zinc; C501987:zinpyr-1
references.citation: J Am Chem Soc. 2010 Jan 20;132(2):601-10
references.pmid: 20000765
references.citation: Chem Rev. 2008 May;108(5):1517-49
references.pmid: 18426241
references.citation: Org Lett. 2003 Jun 12;5(12):2029-31
references.pmid: 12790520
references.citation: J Am Chem Soc. 2001 Aug 15;123(32):7831-41
references.pmid: 11493056
references.citation: Angew Chem Int Ed Engl. 2001;40(16):3066-9
references.pmid: 12203651
references.citation: Acta Radiol. 1997 Jul;38(4 Pt 2):677-89
references.pmid: 9245963
references.citation: Inorg Chem. 2010 Mar 15;49(6):2589-91
references.pmid: 20141114
references.citation: J Am Chem Soc. 2004 Apr 21;126(15):4972-8
references.pmid: 15080703
references.citation: Curr Opin Chem Biol. 2010 Apr;14(2):225-30
references.pmid: 20097117
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10780-5
references.pmid: 17578918
references.citation: J Am Chem Soc. 2009 May 27;131(20):7142-52
references.pmid: 19405465
references.citation: J Neurosci Res. 2008 Feb 1;86(2):422-34
references.pmid: 17847078
references.citation: Chem Commun (Camb). 2009 Jun 28;(24):3511-24
references.pmid: 19521594
references.citation: Inorg Chem. 2008 Jun 16;47(12):5169-76
references.pmid: 18479122
references.citation: J Biol Inorg Chem. 2002 Mar;7(3):241-8
references.pmid: 11935348
references.citation: Org Lett. 2009 Aug 6;11(15):3454-7
references.pmid: 19719190
references.citation: Angew Chem Int Ed Engl. 2006 Dec 11;45(48):8160-2
references.pmid: 17103471