title: [Actively induced hypothermia following severe traumatic brain injury].
abstract: A Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic brain injury reduces cerebral perfusion in the penumbra zone, where local circulation is already reduced. Thus, to date there is no indication for therapeutic hypothermia in TBI patients.
authors.affiliation: Universitetssygehuset i Lund, Anaestesi- og Intensivafdelingen, Denmark.
authors.forename: Per-Olof
authors.initials: PO
authors.lastname: Grände
authors.forename: Karen-Lise
authors.initials: KL
authors.lastname: Welling
authors.forename: Vagn
authors.initials: V
authors.lastname: Eskesen
authors.forename: Bertil
authors.initials: B
authors.lastname: Romner
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000628:therapy*; D002648:Child; D019317:Evidence-Based Medicine; D006801:Humans; D007036:Hypothermia, Induced; D002546:Ischemic Attack, Transient / Q000628:therapy; D011379:Prognosis; D016896:Treatment Outcome