title: UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes.
abstract: Interactions of the ESCRT complexes are critical for endosomal trafficking. We identify two domains with potential significance for this process. The MABP domain present in metazoan ESCRT-I/MVB12 subunits, Crag, a regulator of protein sorting, and bacterial pore-forming proteins might mediate novel membrane interactions in trafficking. The UBAP1-MVB12-associated UMA domain found in MVB12 and UBAP1 defines a novel adaptor that might recruit diverse targets to ESCRT-I.
  
  
  BACKGROUND
  Supplementary data are available at ftp://ftp.ncbi.nih.gov/pub/aravind/UMA/MVB12.html.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: Robson F
authors.initials: RF
authors.lastname: de Souza
authors.forename: L
authors.initials: L
authors.lastname: Aravind
mesh_terms: D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport / Q000737:chemistry / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D002352:Carrier Proteins; D056827:Endosomal Sorting Complexes Required for Transport
references.citation: Nat Genet. 2001 Jun;28(2):119-20
references.pmid: 11381253
references.citation: Mol Cell. 2010 Feb 12;37(3):370-82
references.pmid: 20159556
references.citation: PLoS One. 2007 Sep 26;2(9):e956
references.pmid: 17895996
references.citation: J Biol Chem. 2006 Sep 29;281(39):28919-31
references.pmid: 16895919
references.citation: Dev Cell. 2008 Mar;14(3):354-64
references.pmid: 18331716
references.citation: Nature. 2009 Mar 26;458(7237):445-52
references.pmid: 19325624
references.citation: Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
references.pmid: 9254694
references.citation: J Cell Biol. 2006 Dec 4;175(5):815-23
references.pmid: 17145965
references.citation: Neurobiol Aging. 2009 Apr;30(4):656-65
references.pmid: 19217189
references.citation: BMC Bioinformatics. 2005 Dec 12;6:298
references.pmid: 16343337
references.citation: Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8
references.pmid: 15980461
references.citation: Traffic. 2005 Jun;6(6):429-41
references.pmid: 15882441
references.citation: Bioinformatics. 1998;14(10):892-3
references.pmid: 9927721
references.citation: Curr Genomics. 2009 Jun;10(4):216-22
references.pmid: 19949542
references.citation: Cell Host Microbe. 2007 Jul 12;2(1):41-53
references.pmid: 18005716
references.citation: Biochim Biophys Acta. 2010 Feb;1800(2):172-80
references.pmid: 19665047
references.citation: PLoS Comput Biol. 2008 May 30;4(5):e1000069
references.pmid: 18516236
references.citation: Biochem Biophys Res Commun. 2001 Sep 28;287(3):688-95
references.pmid: 11563850
references.citation: Science. 2007 Sep 14;317(5844):1548-51
references.pmid: 17717151
references.citation: Trends Biochem Sci. 1996 Jan;21(1):3-6
references.pmid: 8848836
references.citation: Biochem Soc Trans. 2008 Feb;36(Pt 1):94-8
references.pmid: 18208393