Immunological and regenerative properties of cord blood stem cells.
Cord blood stem cells (CB-SCs) have shown impressive immunological and regenerative capabilities. In this review, we intend to review the state-of-the-art knowledge on CB-SCs characteristics and function as well as immunological and regenerative properties. We report an itemized classification of CB-SCs populations, which is important to better understand which tissues can be replaced using CB-SCs and how the generation of induced pluripotent stem cells from CB-SCs is changing the field. Furthermore, we will discuss new findings on the immunosuppressive capability of CB-SCs in autoimmune disease (e.g., type 1 diabetes). Our review will demonstrate how CB-SCs could become a powerful tool not only for regenerative medicine but for autoimmune and inflammatory diseases as well.
Francese
Roberto
R
Dipartimento di Medicina ed Oncologia Sperimentale, Università degli Studi di Torino, Italy; Sorgente Research, Milano, Italy.
Fiorina
Paolo
P
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D002986:Clinical Trials as Topic; D036101:Cord Blood Stem Cell Transplantation; D004700:Endocrine System Diseases / Q000628:therapy; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology / Q000502:physiology; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D008661:Metabolism, Inborn Errors / Q000628:therapy; D009422:Nervous System Diseases / Q000628:therapy; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000276:immunology* / Q000502:physiology*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous