title: Lensfree microscopy on a cellphone.
abstract: We demonstrate lensfree digital microscopy on a cellphone. This compact and light-weight holographic microscope installed on a cellphone does not utilize any lenses, lasers or other bulky optical components and it may offer a cost-effective tool for telemedicine applications to address various global health challenges. Weighing approximately 38 grams (<1.4 ounces), this lensfree imaging platform can be mechanically attached to the camera unit of a cellphone where the samples are loaded from the side, and are vertically illuminated by a simple light-emitting diode (LED). This incoherent LED light is then scattered from each micro-object to coherently interfere with the background light, creating the lensfree hologram of each object on the detector array of the cellphone. These holographic signatures captured by the cellphone permit reconstruction of microscopic images of the objects through rapid digital processing. We report the performance of this lensfree cellphone microscope by imaging various sized micro-particles, as well as red blood cells, white blood cells, platelets and a waterborne parasite (Giardia lamblia).
authors.affiliation: UCLA Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Tseng
authors.forename: Onur
authors.initials: O
authors.lastname: Mudanyali
authors.forename: Cetin
authors.initials: C
authors.lastname: Oztoprak
authors.forename: Serhan O
authors.initials: SO
authors.lastname: Isikman
authors.forename: Ikbal
authors.initials: I
authors.lastname: Sencan
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Yaglidere
authors.forename: Aydogan
authors.initials: A
authors.lastname: Ozcan
mesh_terms: D040421:Cell Phone; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006696:Holography / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation*; D007909:Lenses; D008029:Lighting / Q000295:instrumentation*; D008853:Microscopy / Q000295:instrumentation*; D012666:Semiconductors
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