title: Long term consequences of oxygen therapy in the neonatal period.
abstract: Preterm and term infants are frequently exposed to high concentrations of oxygen for prolonged periods. In experimental models, high and prolonged oxygen exposures cause delayed alveolar septation and a bronchopulmonary dysplasia phenotype. Often, however, the oxygen exposure is tolerated in that the infants recover without severe lung or systemic injury. Multiple exposures change oxygen sensitivity in adult and newborn animals. Examples are antenatal corticosteroids, inflammatory mediators or preconditioning with oxygen, which will increase tolerance to oxygen injury. Intrauterine growth restriction or postnatal nutritional deficits will increase oxygen injury. Different infants probably have quite variable sensitivities to oxygen injury, but there are no biomarkers available to predict the risk of oxygen injury.
authors.affiliation: Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA. alan.jobe@chmcc.org
authors.forename: Alan H
authors.initials: AH
authors.lastname: Jobe
authors.forename: Suhas G
authors.initials: SG
authors.lastname: Kallapur
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D001997:Bronchopulmonary Dysplasia / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D055370:Lung Injury / Q000378:metabolism; D010100:Oxygen / Q000008:administration & dosage* / Q000009:adverse effects; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects / Q000379:methods*
chemical_list: D000305:Adrenal Cortex Hormones; D010100:Oxygen
references.citation: Arch Dis Child Fetal Neonatal Ed. 2001 Mar;84(2):F106-10
references.pmid: 11207226
references.citation: Am J Pathol. 1976 Dec;85(3):623-50
references.pmid: 998734
references.citation: Pediatrics. 2000 Feb;105(2):295-310
references.pmid: 10654946
references.citation: Pediatrics. 2009 Sep;124(3):e439-49
references.pmid: 19661049
references.citation: Pediatr Res. 1985 Mar;19(3):281-6
references.pmid: 3982889
references.citation: Biol Neonate. 1979;36(1-2):1-9
references.pmid: 476207
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov;45(5):699-704
references.pmid: 730565
references.citation: Pediatrics. 2003 Feb;111(2):339-45
references.pmid: 12563061
references.citation: Am J Respir Crit Care Med. 2008 May 15;177(10):1103-10
references.pmid: 18292469
references.citation: N Engl J Med. 1967 Feb 16;276(7):357-68
references.pmid: 5334613
references.citation: Pediatr Res. 1999 Dec;46(6):641-3
references.pmid: 10590017
references.citation: Pediatrics. 2009 Apr;123(4):1124-31
references.pmid: 19336371
references.citation: Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L641-9
references.pmid: 19617311
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1979 Sep;47(3):577-81
references.pmid: 533752
references.citation: Am J Respir Crit Care Med. 1995 Aug;152(2):640-6
references.pmid: 7633720
references.citation: Pediatr Res. 2009 Jul;66(1):3-10
references.pmid: 19287338
references.citation: Am J Physiol. 1984 Sep;247(3 Pt 2):R475-81
references.pmid: 6476146
references.citation: Am Rev Respir Dis. 1987 Sep;136(3):677-82
references.pmid: 3307571
references.citation: Semin Perinatol. 1991 Dec;15(6):462-8
references.pmid: 1803523
references.citation: Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1099-110
references.pmid: 17704187
references.citation: Antioxid Redox Signal. 2009 Dec;11(12):2945-55
references.pmid: 19645572
references.citation: N Engl J Med. 2003 Sep 4;349(10):959-67
references.pmid: 12954744
references.citation: Pediatr Res. 2003 Apr;53(4):679-83
references.pmid: 12612216
references.citation: Pediatr Res. 1991 Mar;29(3):292-6
references.pmid: 2034478
references.citation: Crit Care. 2006;10(2):R41
references.pmid: 16542488
references.citation: Am J Physiol. 1998 Jul;275(1):L110-7
references.pmid: 9688942
references.citation: Am J Physiol. 1989 Oct;257(4 Pt 1):L226-31
references.pmid: 2801950
references.citation: J Perinatol. 2006 Nov;26(11):700-5
references.pmid: 17036032
references.citation: Brain Res. 2009 Mar 13;1260:47-54
references.pmid: 19167368
references.citation: Prog Brain Res. 2007;162:373-92
references.pmid: 17645928
references.citation: Semin Neonatol. 2003 Feb;8(1):73-81
references.pmid: 12667832
references.citation: J Pediatr. 2002 Feb;140(2):171-6
references.pmid: 11865267
references.citation: Pediatrics. 2000 Jun;105(6):1194-201
references.pmid: 10835057
references.citation: Pediatr Res. 1978 Feb;12(2):115-9
references.pmid: 643379
references.citation: Pediatr Res. 2006 Sep;60(3):294-8
references.pmid: 16857758
references.citation: J Appl Physiol (1985). 1998 Jul;85(1):273-8
references.pmid: 9655786
references.citation: J Appl Physiol (1985). 2006 Mar;100(3):869-79
references.pmid: 16306257
references.citation: Pediatr Res. 1987 Feb;21(2):109-15
references.pmid: 3822589
references.citation: Semin Neonatol. 2003 Feb;8(1):63-71
references.pmid: 12667831
references.citation: Pediatr Res. 2009 Jan;65(1):33-8
references.pmid: 18703992
references.citation: J Appl Physiol (1985). 1986 Apr;60(4):1209-12
references.pmid: 3700305