title: Platinum(II) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity.
abstract: Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
authors.forename: Zuqin
authors.initials: Z
authors.lastname: Xue
authors.forename: Miaoxin
authors.initials: M
authors.lastname: Lin
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhu
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Li
authors.forename: Zijian
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008958:Models, Molecular; D012516:Osteosarcoma / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017671:Platinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds; D002945:Cisplatin