title: Environmental versus dietary exposure to POPs and metals: a probabilistic assessment of human health risks.
abstract: The human health risks derived from the multipathway/multipollutant exposure to various chemicals were assessed in an area with significant petrochemical activity (Tarragona, Catalonia, Spain). Environmental exposure to several Persistent Organic Pollutants (POPs) (PCDD/Fs, PCBs, PCNs, and PAHs) and metals (As, Cd, Cr, Hg, Mn, Pb, and V) was determined and compared with the dietary intake of these pollutants. The mean environmental exposure to organic pollutants ranged from 6.36 x 10(-6) ng WHO-TEQ kg(-1) day(-1) to 3.34 ng kg(-1) day(-1) for PCDD/Fs and PAHs, respectively. In turn, the minimum and maximum values of environmental exposure to metals corresponded to Cd (9.35 x 10(-8) mg kg(-1) day(-1)) and Mn (8.72 x 10(-5) mg kg(-1) day(-1)), respectively. Among the environmental exposure pathways, dermal absorption and soil ingestion were the most important pathways for POPs and metals, respectively. However, this exposure was notably lower than the dietary intake of these contaminants, with percentages of <2% for most of them. Considering cumulative effects, the current concentrations of micropollutants do not mean significant additional non-carcinogenic and carcinogenic human health risks. Notwithstanding, in order to consider the synergistic/antagonistic effects according to the target organ or mode-of-action, the development of alternative methodologies of risk assessment are necessary for a more accurate evaluation.
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Sant Llorenç 21, 43201 Reus, Catalonia, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Linares
authors.forename: Gemma
authors.initials: G
authors.lastname: Perelló
authors.forename: Martí
authors.initials: M
authors.lastname: Nadal
authors.forename: Jesús
authors.initials: J
authors.lastname: Gómez-Catalán
authors.forename: Juan M
authors.initials: JM
authors.lastname: Llobet
authors.forename: José L
authors.initials: JL
authors.lastname: Domingo
mesh_terms: D004147:Dioxins / Q000032:analysis*; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000032:analysis*; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008670:Metals / Q000032:analysis*; D008954:Models, Biological; D015233:Models, Statistical; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D018570:Risk Assessment
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants; D008670:Metals; D011084:Polycyclic Aromatic Hydrocarbons; D011078:Polychlorinated Biphenyls