title: Neuropsychiatric symptoms in dementia patients with and without a history of traumatic brain injury.
abstract: The authors aim to determine if a history of traumatic brain injury (TBI) assessed before dementia onset is associated with a higher risk of neuropsychiatric symptoms after dementia onset. A population-based incident series of people with dementia were assessed for TBI prior to onset of dementia and for neuropsychiatric symptoms after the onset, using the Neuropsychiatric Inventory. Participants with predementia TBI were more likely to exhibit disinhibition (12.7% versus 5.4%, OR=2.8, p=0.02), but not other neuropsychiatric symptoms. Traumatic brain injury may increase the risk of disinhibition in patients with dementia.
authors.affiliation: Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21224, USA. vrao@jhmi.edu
authors.forename: Vani
authors.initials: V
authors.lastname: Rao
authors.forename: Paul
authors.initials: P
authors.lastname: Rosenberg
authors.forename: Quincy Samus
authors.initials: QS
authors.lastname: Miles
authors.forename: Deepa
authors.initials: D
authors.lastname: Patadia
authors.forename: Kate
authors.initials: K
authors.lastname: Treiber
authors.forename: Melaine
authors.initials: M
authors.lastname: Bertrand
authors.forename: Maria
authors.initials: M
authors.lastname: Norton
authors.forename: Martin
authors.initials: M
authors.lastname: Steinberg
authors.forename: JoAnn
authors.initials: J
authors.lastname: Tschanz
authors.forename: Constantine
authors.initials: C
authors.lastname: Lyketsos
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001930:Brain Injuries / Q000453:epidemiology* / Q000235:genetics; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000453:epidemiology / Q000235:genetics; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000235:genetics; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: D053327:Apolipoprotein E4
references.citation: Neuropsychiatry Neuropsychol Behav Neurol. 2002 Mar;15(1):28-38
references.pmid: 11877549
references.citation: Psychol Med. 1994 Feb;24(1):145-53
references.pmid: 8208879
references.citation: Am J Psychiatry. 2000 May;157(5):708-14
references.pmid: 10784462
references.citation: Brain Inj. 2001 Mar;15(3):255-62
references.pmid: 11260773
references.citation: Hum Mol Genet. 1993 Feb;2(2):159-63
references.pmid: 7684637
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Am J Ther. 2004 May-Jun;11(3):231-5
references.pmid: 15133540
references.citation: J Clin Psychiatry. 1987 Aug;48(8):314-8
references.pmid: 3611032
references.citation: Neurology. 1993 Aug;43(8):1467-72
references.pmid: 8350998
references.citation: J Neuropsychiatry Clin Neurosci. 2000 Spring;12(2):233-9
references.pmid: 11001602
references.citation: Alzheimer Dis Assoc Disord. 2005 Jan-Mar;19(1):37-40
references.pmid: 15764870
references.citation: Psychosomatics. 2003 Sep-Oct;44(5):388-401
references.pmid: 12954913
references.citation: J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):146-8
references.pmid: 14707327
references.citation: Gerontologist. 2005 Oct;45 Spec No 1(1):19-26
references.pmid: 16230746
references.citation: JAMA. 2005 Feb 2;293(5):596-608
references.pmid: 15687315
references.citation: Neurology. 2002 Jan 22;58(2):209-18
references.pmid: 11805246
references.citation: Am J Psychiatry. 1986 Oct;143(10):1279-82
references.pmid: 3766791
references.citation: JAMA. 2002 Sep 25;288(12):1475-83
references.pmid: 12243634
references.citation: J Neuropsychiatry Clin Neurosci. 1997 Spring;9(2):222-30
references.pmid: 9144101
references.citation: Neurology. 1993 Feb;43(2):250-60
references.pmid: 8094895
references.citation: Mov Disord. 2000 May;15(3):490-6
references.pmid: 10830414
references.citation: Neurology. 1994 Dec;44(12):2308-14
references.pmid: 7991117
references.citation: Int Psychogeriatr. 2008 Feb;20(1):149-61
references.pmid: 17466086
references.citation: J Neuropsychiatry Clin Neurosci. 2007 Winter;19(1):43-9
references.pmid: 17308226
references.citation: Am J Geriatr Psychiatry. 2007 Apr;15(4):314-27
references.pmid: 17384314
references.citation: J Neuropsychiatry Clin Neurosci. 2006 Fall;18(4):445-9
references.pmid: 17135372
references.citation: Int J Geriatr Psychiatry. 2000 Feb;15(2):181-9
references.pmid: 10679850
references.citation: Neurology. 1999 Jul 22;53(2):321-31
references.pmid: 10430421
references.citation: Brain Inj. 2007 Mar;21(3):301-7
references.pmid: 17453758
references.citation: Pharmacopsychiatry. 2005 May;38(3):144-5
references.pmid: 15902587
references.citation: Int J Geriatr Psychiatry. 2004 Nov;19(11):1087-94
references.pmid: 15481065