[Extra nuclear localization of steroid receptors and non genomic activation mechanisms].
Steroid hormone receptors have been historically considered as nuclear transcription factors. Nevertheless, in the last years, many of them have been detected in the cellular membrane. It has been postulated that their activation can induce transcription independent rapid events involving different second messengers. In addition, several novel steroid hormone receptors, showing a different molecular structure than the classical ones, have also been characterized and most of them are also located in the plasmatic membrane. This review focuses on the variety of effects initiated by glucocorticoids, mineralocorticoids, androgens, estrogens and progesterone, and the possible receptors involved mediating these effects.
Bottino
María Cecilia
MC
Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires. mbottino@leloir.org.ar
Lanari
Claudia
C
D000728:Androgens / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D004967:Estrogens / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D008901:Mineralocorticoids / Q000502:physiology; D011374:Progesterone / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D000728:Androgens; D004967:Estrogens; D005938:Glucocorticoids; D008901:Mineralocorticoids; D011956:Receptors, Cell Surface; D011987:Receptors, Steroid; D011374:Progesterone