Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: from basics to recent advances.
Systemic lupus erythematosus (SLE) is a complex auto-immune disorder which involves various facets of the immune system. In addition to autoantibody production and immune complex deposition, emerging evidences suggest that cytokines may act as key players in the immunopathogenesis of SLE. These cytokines assume a critical role in the differentiation, maturation and activation of cells and also participate in the local inflammatory processes that mediate tissue insults in SLE. Certain cytokines such as the IL-6, IL-10, IL-17, BLys, type I interferons (IFN) and tumor necrosis factor-alpha (TNF-alpha) are closely linked to pathogenesis of SLE. The delineation of the role played by these cytokines not only fosters our understanding of this disease but also provides a sound rationale for various therapeutic approaches. In this context, this review focuses on selected cytokines which exert significant effect in the pathogenesis of SLE and their possible clinical applications.
Yap
Desmond Yat Hin
DY
Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong.
Lai
Kar Neng
KN
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D051379:Mice; D008954:Models, Biological
D016207:Cytokines
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