Ten-year graft survival of deceased-donor kidney transplantation: a single-center experience.
BACKGROUND
Kidney transplantation is the treatment of choice for end-stage renal disease that restores the patients' quality of life and reduces the morbidity and mortality rates induced by renal failure and its complications. However, after transplantation the organ and patient survival rates are important issues of interest in many centers worldwide.


METHODS
This is a historical cohort study planned to determine the organ survival rate after kidney transplantation from deceased donor during a period of 10 years (March 1999-March 2009) in Shiraz Transplant Center, Namazi Hospital, Shiraz, Iran. We tried to clarify the probable contributory risk factors implicating in graft loss. Kaplan-Meier method was used to determine the survival rate. Log-rank test was used to compare survival curves, and Cox regression model to define the hazard ratio and for modeling of factors implicating in survival rate.


RESULTS
Mean follow-up period was 37.54 +/- 28.6 months. Allograft survival rates at 1, 3, 5, and 9 years after kidney transplantation from deceased donor (calculated by Kaplan-Meier method) was found to be 93.7, 89.1, 82.1, and 80.1%, respectively. Duration of dialysis before operation and creatinine level at discharge were showed to be the most important factors influencing survival rate of renal allograft.


CONCLUSIONS
Overall long-term graft survival in our cohort is satisfactory and comparable with reports from large centers in the world. Duration of dialysis before operation and creatinine level at discharge are the only independent factors that could correlate with long-term graft survival in our cohort.
Hashiani
Amir Almasi
AA
Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Rajaeefard
Abdolreza
A
Hasanzadeh
Jafar
J
Kakaei
Farzad
F
Behbahan
Afshin Ghalehgolab
AG
Nikeghbalian
Saman
S
Salahi
Heshmatollah
H
Bahador
Ali
A
Salehipour
Mehdi
M
Malek-Hosseini
Seyed Ali
SA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003404:Creatinine / Q000032:analysis; D005260:Female; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007223:Infant; D007492:Iran / Q000453:epidemiology; D016030:Kidney Transplantation / Q000401:mortality; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012307:Risk Factors; D015996:Survival Rate
D003404:Creatinine