Ameliorative effect of a combination of vitamin E, vitamin C, alpha-lipoic acid and stilbene resveratrol on lindane induced toxicity in mice olfactory lobe and cerebrum.
Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Pretreatment by a combination of antioxidants, vitamin E, vitamin C, a- lipoic acid and stilbene resveratrol (125 mg/kg body weight, ip) significantly augment the altered level of BChE and protect the other parameters in both the brain regions. The results were adequately in agreement with the histochemical findings, suggesting the neuroprotective efficacy of combination of antioxidants studied on the lindane induced neurotoxicity.
Bano
Mehajbeen
M
banomehaj2001@hotmail.com
Bhatt
Devendra Kumar
DK
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002648:Child; D002784:Cholesterol / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D006801:Humans; D007223:Infant; D007306:Insecticides / Q000633:toxicity; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology; D009833:Olfactory Pathways / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000378:metabolism / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D008063:Thioctic Acid / Q000378:metabolism / Q000494:pharmacology*; D014810:Vitamin E / Q000378:metabolism / Q000494:pharmacology*
D000975:Antioxidants; D007306:Insecticides; D018696:Neuroprotective Agents; D013267:Stilbenes; D014810:Vitamin E; D001556:Hexachlorocyclohexane; D008063:Thioctic Acid; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase; D002091:Butyrylcholinesterase; D001205:Ascorbic Acid; D000077185:Resveratrol