The role of echocardiographic deformation imaging in hypertrophic myopathies.
Echocardiography has a leading role in the routine assessment and diagnosis of hypertrophic ventricles. However, the use of M-mode echocardiography and measurement of global left ventricular function may be misleading. Traditionally, systolic function was thought to be preserved in patients with hypertrophic myopathies until the late stages of the disease, and hypertrophic myopathies were thought to affect the myocardium more diffusely than ischemic heart disease. Ultrasound deformation imaging, either by Doppler myocardial imaging or speckle tracking, provides more-sensitive detection of regional myocardial motion and deformation than standard echocardiography. Basic and clinical studies that apply these techniques have revealed early, often subclinical impairment in systolic function. This information allows the detection and treatment of myocardial dysfunction at an early stage, which is of high clinical importance. Physiological hypertrophic remodeling seen in athletes differs from pathological myocardial hypertrophy, which can be caused by compensatory reactive hypertrophy owing to pressure overload in patients with aortic stenosis or hypertension, as well as amyloidosis, Fabry disease or Friedreich ataxia. Each of the etiologies associated with hypertrophy demonstrate distinct regional changes in myocardial deformation, which allows identification of the underlying processes, and will improve the assessment and follow-up of patients with hypertrophic myopathies.
Cikes
Maja
M
University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. maja_cikes@yahoo.com
Sutherland
George R
GR
Anderson
Lisa J
LJ
Bijnens
Bart H
BH
D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D015150:Echocardiography, Doppler; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
Am J Cardiol. 1999 Nov 1;84(9):1061-7
10569664
Lancet. 1999 Aug 7;354(9177):477-9
10465173
Eur J Echocardiogr. 2008 Jul;9(4):501-8
17905662
Lancet. 2004 Jun 5;363(9424):1881-91
15183628
J Am Soc Echocardiogr. 2008 Sep;21(9):1049-54
18406573
Eur J Echocardiogr. 2009 Dec;10(8):914-21
19666722
Am J Cardiol. 2002 May 1;89(9):1067-71
11988197
Am Heart J. 2000 Jun;139(6):1101-8
10827394
Ann Intern Med. 1975 Apr;82(4):521-4
1119766
Heart. 2005 Aug;91(8):1036-40
16020591
Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H610-20
11158958
Circulation. 2002 Apr 2;105(13):1602-8
11927530
Circulation. 2005 Sep 27;112(13):2047-60
16186440
N Engl J Med. 2001 Jul 5;345(1):9-16
11439963
Am J Cardiol. 2008 Apr 1;101(7):1039-45
18359328
Circulation. 1996 Mar 1;93(5):841-2
8598070
J Magn Reson Imaging. 2008 May;27(5):1054-60
18425835
Circulation. 1999 Jan 19;99(2):254-61
9892592
Circulation. 2004 Dec 21;110(25):3808-14
15583080
Circulation. 1991 May;83(5):1676-84
1827056
J Am Soc Echocardiogr. 2007 May;20(5):539-51
17485001
Circulation. 2005 Jan 18;111(2):186-93
15630027
Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1609-15
12234815
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2843-5
2320592
Am J Cardiol. 2008 May 15;101(10):1493-7
18471464
Am J Cardiol. 2003 Mar 1;91(5):622-6
12615279
Circulation. 2009 Aug 18;120(7):577-84
19652094
J Cardiovasc Magn Reson. 2007;9(6):891-8
18066749
Eur Heart J. 2007 Dec;28(23):2886-94
17971400
J Am Coll Cardiol. 1990 Nov;16(5):1135-41
2229760
Am J Cardiol. 1998 Dec 1;82(11):1394-8
9856926
Am J Physiol. 1989 Oct;257(4 Pt 2):H1119-26
2801973
Circ Res. 2004 Apr 30;94(8):1008-10
15044325
Heart. 2010 Jan;96(1):49-55
19858137
J Am Coll Cardiol. 1986 Jun;7(6):1370-8
2940284
Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1699-705
16272203
Res Exp Med (Berl). 1980;177(3):201-11
6449727
Circulation. 2003 Feb 25;107(7):984-91
12600911
Arch Intern Med. 2005 Jun 27;165(12):1425-9
15983293
Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H792-9
12124229
Circulation. 1981 Apr;63(4):882-94
7193536
J Am Coll Cardiol. 2006 Mar 21;47(6):1175-81
16545649
J Am Coll Cardiol. 1983 Sep;2(3):437-44
6683731
Circulation. 2001 Aug 28;104(9):1059-65
11524402
Circulation. 2003 May 20;107(19):2446-52
12743000
Circulation. 2007 Nov 20;116(21):2453-64
18025403
Eur Heart J. 2008 Jan;29(2):270-6
17916581
J Am Coll Cardiol. 1987 Oct;10(4):733-42
3655141
Ultrasound Med Biol. 2006 Oct;32(10):1509-13
17045871
J Am Soc Echocardiogr. 2003 Mar;16(3):233-9
12618731
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1573-9
16679404
J Hum Hypertens. 2006 Sep;20(9):666-71
16738687
Eur Heart J. 2007 Dec;28(24):3020-6
17981828
Br J Sports Med. 2010 Sep;44(12):872-8
19136502
Int J Cardiol. 2002 Dec;86(2-3):177-84
12419554
Eur Heart J. 1992 Sep;13 Suppl D:17-23
1396854
Am J Cardiol. 2000 May 1;85(9):1131-6
10781765
Neurology. 2003 May 27;60(10):1679-81
12771265
Eur Heart J. 2003 Dec;24(23):2151-5
14643276
Heart. 2008 Oct;94(10):1302-6
18198205
Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H898-906
10710359
Semin Hematol. 1995 Jan;32(1):45-59
7878478
J Am Soc Echocardiogr. 2009 Sep;22(9):1025-30
19556106
J Am Coll Cardiol. 2001 Aug;38(2):315-21
11499718
Scand J Med Sci Sports. 2007 Apr;17(2):148-55
17394476
Eur J Echocardiogr. 2006 Mar;7(2):79-108
16458610
Hypertension. 1985 Jan-Feb;7(1):97-104
3980063
Cell. 1987 Dec 24;51(6):919-28
3319190
Circulation. 1994 Jan;89(1):122-31
8281637
J Am Geriatr Soc. 1975 Mar;23(3):97-103
122982
J Am Soc Echocardiogr. 2005 Dec;18(12):1247-53
16376750
Circulation. 1998 Feb 24;97(7):666-72
9495302
Eur J Echocardiogr. 2009 Mar;10(2):216-26
19098303
Eur Heart J. 2004 Sep;25(17):1517-25
15342171
Arch Intern Med. 2006 Sep 25;166(17):1805-13
17000935
Am Heart J. 2007 Nov;154(5):937-42
17967601
J Am Coll Cardiol. 2003 Aug 6;42(3):486-94
12906978
Ultrasound Med Biol. 2001 Aug;27(8):1087-97
11527595
Circulation. 1994 Sep;90(3):1200-9
8087929
J Clin Invest. 1975 Jul;56(1):56-64
124746
J Am Soc Echocardiogr. 2008 Dec;21(12):1309-17
19041574
Br Heart J. 1969 Jan;31(1):5-14
5774037
Annu Rev Physiol. 1983;45:169-89
6221687
Am J Cardiol. 2008 Sep 15;102(6):784-9
18774007
J Am Coll Cardiol. 1995 Jul;26(1):195-202
7797752
Cathet Cardiovasc Diagn. 1983;9(5):463-71
6640662
Circulation. 2003 Apr 22;107(15):1978-84
12668521
Clin Physiol Funct Imaging. 2010 Jan;30(1):6-12
19744087
Am J Cardiol. 2009 Feb 1;103(3):411-5
19166699
J Am Coll Cardiol. 1992 Jun;19(7):1550-8
1534335
Blood Press. 2004;13(2):101-9
15182113
Eur J Echocardiogr. 2009 Jan;10(1):112-9
18579501
Ultrasound Med Biol. 2007 Dec;33(12):1963-70
17673356
Hum Mol Genet. 2000 Jan 22;9(2):275-82
10607838
Circulation. 1997 Jul 1;96(1):214-9
9236436
Prog Cardiovasc Dis. 1995 May-Jun;37(6):371-96
7777668
Ultrasound Med Biol. 2003 Aug;29(8):1085-92
12946511
J Am Coll Cardiol. 2006 Nov 21;48(10):2026-33
17112992
Circulation. 2009 Feb 3;119(4):524-9
19153271
Eur Heart J. 2007 Nov;28(21):2627-36
17526904
Am J Cardiol. 2006 May 15;97(10):1515-8
16679096
Lancet. 2006 Jan 28;367(9507):356-67
16443044
Echocardiography. 2006 Feb;23(2):149-57
16445736
J Am Soc Echocardiogr. 2008 Oct;21(10):1129-37
18486443
Am Heart J. 2009 Oct;158(4):540-5
19781412
Science. 1996 May 3;272(5262):731-4
8614836
Eur Heart J. 2005 Jun;26(12):1221-7
15728649
JAMA. 1999 Jan 20;281(3):249-54
9918480
Am Heart J. 2004 May;147(5):919-23
15131552
J Am Coll Cardiol. 2004 Jul 7;44(1):144-9
15234423
Curr Opin Cardiol. 2004 Sep;19(5):430-6
15316448
QJM. 1998 Feb;91(2):141-57
9578896
Arch Cardiovasc Dis. 2008 Jan;101(1):61-8
18391875
Clin Res Cardiol. 2008 Feb;97(2):65-73
17713717
Heart. 2008 Feb;94(2):e3
17916666
J Am Soc Echocardiogr. 2005 Jul;18(7):737-42
16003271
Eur J Clin Invest. 2004 Mar;34(3):236-42
15025684
Heart. 2009 Apr;95(8):657-61
18977803
Pediatr Rev. 2006 Mar;27(3):83-8
16510548
J Am Soc Echocardiogr. 2006 Aug;19(8):987-93
16880093
Eur Heart J. 2003 Nov;24(21):1965-91
14585256
AJR Am J Roentgenol. 2002 Apr;178(4):953-8
11906882
Am J Cardiol. 2007 Jul 1;100(1):128-32
17599454
Am J Cardiol. 2001 Jul 1;88(1):53-8
11423058
Int J Cardiol. 2003 Jul;90(1):33-8; discussion 38-40
12821216
N Engl J Med. 1998 Apr 30;338(18):1248-57
9562578
Br Heart J. 1981 Mar;45(3):248-63
7008815
Circulation. 1999 Jul 27;100(4):361-8
10421595
J Am Soc Echocardiogr. 2004 Jan;17(1):36-44
14712185
Circulation. 2000 Sep 12;102(11):1276-82
10982543
Am Heart J. 1985 Jul;110(1 Pt 1):84-90
3160227
Circulation. 2003 Sep 16;108(11):1299-301
12952834