Evidence-based consensus recommendations to improve the quality of life in prostate cancer treatment.
BACKGROUND
Prostate cancer (PC) is one of the tumours with the highest incidence in recent years. PC therapies have several adverse effects. A panel consensus recommendation has been made to prevent or ameliorate complications in PC treatment to improve quality of life.


METHODS
Fifteen specialists have met to analyse the different toxicities associated with PC treatment. Each medical specialist performed a National Library of Medicine PubMed search citations searching about these secondary effects and his specialty from 1999 to 2009 to propose measures for their prevention/amelioration.


RESULTS
Surgery is associated with incontinence and impotence. Radiotherapy can produce acute, late urological and gastrointestinal toxicity. Brachytherapy can produce acute urinary retention. Chemotherapy is associated with haematotoxicity, peripheral neuropathy and diarrhoea, and hormone therapy can produce osteoporosis, metabolic syndrome, cognitive and muscular alterations, cardiotoxicity, etc.


CONCLUSIONS
Improvement in surgical techniques and technology (IMRT/IGRT) can prevent surgical and radiotherapeutic toxicity, respectively. Brachytherapy toxicity can be prevented with precise techniques to preserve the urethra. Chemotherapy toxicity can be prevented with personalized schedules of treatment and close follow-up of iatrogenia and hormone therapy toxicity can be prevented with close follow-up of possible secondary effects.
Casas
Francesc
F
Radiation Oncology Department, Hospital Clínic, Barcelona, Spain. fcasas@clinic.ub.es
Borràs
Josep María
JM
Ferrer
Ferran
F
Guanyabens
Núria
N
Gutiérrez del Pozo
Rafael
R
León
Concha
C
López Torrecilla
José
J
Mellado
Begoña
B
Morote
Joan
J
Puig
Manel
M
Ribal
María José
MJ
Ruscalleda
Carme
C
Serra
Agustí
A
Valls
Valentí
V
Zapatero
Almudena
A
D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001918:Brachytherapy / Q000379:methods; D002277:Carcinoma / Q000523:psychology / Q000628:therapy*; D003131:Combined Modality Therapy; D055317:Evidence-Based Practice; D006287:Health Planning Guidelines; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D011832:Radiation Injuries / Q000517:prevention & control / Q000523:psychology; D011879:Radiotherapy Dosage
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