Cholesterol, CSF 5-HIAA, violence and intent in suicidal men.
Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between serum cholesterol, CSF 5-HIAA, the planning subscale of suicide intent and violence of attempted suicide method in 13 medication-free male suicide attempters and eight healthy volunteers. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in suicide attempters than in controls. HDL-C showed a significant positive correlation with the planning subscale of suicide intent in non-violent suicide attempters. A positive association was observed between CSF 5-HIAA and serum cholesterol in suicides. The role of cholesterol may be different in planned non-violent suicide attempts compared with violent suicide attempts.
Jokinen
Jussi
J
Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden. jussi.jokinen@ki.se
Nordström
Anna-Lena
AL
Nordström
Peter
P
D002784:Cholesterol / Q000097:blood*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D013058:Mass Spectrometry; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D013405:Suicide; D013406:Suicide, Attempted; D014754:Violence / Q000523:psychology*
D008074:Lipoproteins; C030104:lipoprotein cholesterol; D006897:Hydroxyindoleacetic Acid; D002784:Cholesterol