Rapid behavioural effects of oestrogens and fast regulation of their local synthesis by brain aromatase.
Besides their genomic effects, oestrogens, 17beta-oestradiol in particular, also activate cellular effects that may be too rapid (seconds to minutes) to result from de novo protein synthesis. Although the existence of such nongenomic actions has been extensively demonstrated in vitro, the understanding of their behavioural significance is only emerging. Recent findings provide evidence that acute oestrogen treatments significantly affect a variety of behavioural processes, including sexual behaviour, social communication and cognition. One question arising from these results concerns the source of the oestrogens mediating nongenomic effects in vivo. In this review, data collected in vitro and in vivo are presented supporting the notion that fast modulations of local testosterone aromatisation can rapidly control the local oestrogen concentration in a time frame compatible with their rapid actions. Taken together, these data provide compelling evidence of how rapid changes in the local production and action of oestrogens can shape complex behaviours.
Cornil
C A
CA
Behavioral Neuroendocrinology Research Group, GIGA Neurosciences, University of Liège, Liège, Belgium. charlotte.cornil@ulg.ac.be
Charlier
T D
TD
D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology*; D004967:Estrogens / Q000096:biosynthesis* / Q000494:pharmacology*; D005786:Gene Expression Regulation; D011499:Protein Processing, Post-Translational; D011960:Receptors, Estrogen / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D013739:Testosterone; D001141:Aromatase
J Neuroendocrinol. 2001 Jan;13(1):63-73
11123516
Endocr Rev. 2007 Feb;28(1):1-19
17018839
Endocrinology. 1994 Jul;135(1):395-401
8013375
Brain Res. 1976 Sep 10;114(1):152-7
986858
Neuroendocrinology. 1996 Feb;63(2):149-55
9053779
J Neuroendocrinol. 2008 Jun;20(6):705-12
18601693
J Neuroendocrinol. 2009 Mar;21(3):191-9
19207827
Pharmacol Biochem Behav. 1989 Nov;34(3):459-63
2623002
Endocrinology. 1968 Mar;82(3):627-30
5641551
Neuroendocrinology. 1989 Apr;49(4):434-41
2716959
Pharmacol Rev. 1999 Dec;51(4):593-628
10581325
J Chem Neuroanat. 1995 May;8(4):267-82
7669272
J Neurosci Res. 2005 Jul 1;81(1):31-7
15952176
J Neurosci. 2004 Aug 18;24(33):7225-9
15317848
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9840-5
17525148
News Physiol Sci. 2001 Dec;16:251-5
11719599
Mol Endocrinol. 2005 Apr;19(4):833-42
15695368
Nat Neurosci. 2008 Mar;11(3):334-43
18297067
J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):365-74
9365212
Physiol Behav. 1991 Oct;50(4):793-9
1663629
Endocr Rev. 1999 Jun;20(3):279-307
10368772
J Neurosci. 2004 Jun 30;24(26):5892-900
15229236
Horm Behav. 2008 Sep;54(4):488-95
18452920
Carcinogenesis. 1998 Jan;19(1):1-27
9472688
Steroids. 2008 Oct;73(9-10):985-91
18342349
Horm Behav. 1997 Dec;32(3):176-83
9454668
Endocrinology. 2007 Nov;148(11):5288-94
17673514
J Neurosci. 2007 Jun 13;27(24):6563-72
17567817
Trends Pharmacol Sci. 2008 Mar;29(3):116-23
18262661
J Neurosci. 1998 May 15;18(10):3967-76
9570823
Front Neuroendocrinol. 2006 Sep;27(3):247-74
16828853
Horm Behav. 1985 Jun;19(2):174-87
4040115
J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):521-40
8476766
Mol Endocrinol. 2009 Oct;23(10):1634-45
19556341
J Neuroendocrinol. 2005 Sep;17(9):553-9
16101893
Horm Behav. 2005 Mar;47(3):297-305
15708758
Horm Behav. 2006 Jan;49(1):45-67
15963995
Biol Reprod. 1989 May;40(5):929-34
2765616
Horm Behav. 1998 Oct;34(2):126-39
9799623
J Neurosci. 2008 Aug 27;28(35):8660-7
18753366
J Neurobiol. 1996 Oct;31(2):129-48
8885196
J Steroid Biochem Mol Biol. 2008 Nov;112(1-3):95-101
18822378
Science. 1979 Mar 2;203(4383):918-20
570304
Brain Res. 1973 Apr 27;53(2):343-52
4706033
Proc Biol Sci. 2005 Oct 7;272(1576):2089-96
16191621
Recent Prog Horm Res. 1997;52:33-68; discussion 68-9
9238847
J Neurosci. 2009 May 6;29(18):5949-63
19420261
Eur J Pharmacol. 1982 May 7;80(1):65-72
7201404
J Neuroendocrinol. 2005 Oct;17(10):664-71
16159379
J Neurosci. 2002 Oct 1;22(19):8391-401
12351713
Endocrinology. 2006 Jan;147(1):359-66
16195408
J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):307-14
9365206
Brain Res Bull. 1994;35(4):339-45
7850484
Neuroscience. 2003;118(4):941-8
12732239
Endocrinology. 2003 Jul;144(7):2836-44
12810538
J Neurosci. 2009 Feb 11;29(6):1897-903
19211896
J Neurosci. 2009 Aug 26;29(34):10779-83
19710328
J Comp Neurol. 1999 Apr 28;407(1):115-29
10213192
Horm Behav. 1997 Oct;32(2):114-24
9367719
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12267-71
11572951
Endocrinology. 2005 Jan;146(1):287-93
15486220
Endocrinology. 2004 Jul;145(7):3055-61
14976146
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):865-70
14694190
Comp Biochem Physiol B Biochem Mol Biol. 2002 May;132(1):203-15
11997222
Front Neuroendocrinol. 2009 Aug;30(3):259-301
19505496
Endocrinology. 1986 Mar;118(3):968-73
3004902
Endocrinology. 2005 Sep;146(9):3809-20
15932925
Behav Brain Res. 2006 Jan 6;166(1):110-23
16159671
Nat Neurosci. 2008 Nov;11(11):1327-34
18820691
J Comp Neurol. 2000 Aug 7;423(4):619-30
10880992
Anim Behav. 1978 May;26(2):349-57
566522
J Neurosci. 2009 Dec 2;29(48):15323-30
19955385
J Neurosci. 2004 Jan 28;24(4):947-55
14749439
J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):61-5
11850208
J Physiol. 2009 Nov 1;587(Pt 21):5019-23
19687123
J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):247-53
11850231
J Comp Neurol. 2000 Aug 7;423(4):552-64
10880987
J Neurosci. 2007 Aug 29;27(35):9294-300
17728443
J Neurosci. 2007 Jan 31;27(5):1114-22
17267566
Mol Cell Endocrinol. 2008 Aug 13;290(1-2):24-30
18534740
Horm Behav. 2008 Jan;53(1):192-9
17976598
Eur J Neurosci. 2003 Apr;17(8):1591-606
12752377
Am J Physiol. 1999 May;276(5):R1346-50
10233026
Neuropsychopharmacology. 2010 Jan;35(2):547-59
19847162
Ann N Y Acad Sci. 2003 Dec;1007:64-78
14993041
Cancer Res. 1992 Mar 15;52(6):1411-5
1311630
J Neuroendocrinol. 2009 Mar;21(3):217-26
19207825
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12354-7
15302933
Neuroscience. 2008 May 15;153(3):751-61
18406537
Pharmacol Biochem Behav. 1990 Feb;35(2):307-10
2157227
Brain Res. 2006 Dec 18;1126(1):2-26
16978590
Physiol Behav. 1985 Oct;35(4):577-81
4070433
Gen Comp Endocrinol. 1988 Nov;72(2):190-203
2848743
J Neurosci. 2005 May 18;25(20):5066-78
15901789
J Comp Neurol. 1995 Sep 11;360(1):172-84
7499563
Pharmacol Biochem Behav. 1987 May;27(1):53-9
3615546
Pharmacol Biochem Behav. 1992 Sep;43(1):303-6
1409815
J Endocrinol. 1974 Mar;60(3):429-39
4856704
J Neurosci. 2004 Jun 30;24(26):5913-21
15229239
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3852-7
20133597
Horm Behav. 2009 Nov;56(5):519-26
19751737
Annu Rev Pharmacol Toxicol. 2007;47:657-80
16918306