Viral fibroblast growth factor, matrix metalloproteases, and caspases are associated with enhancing systemic infection by baculoviruses.
Most arthropod-borne and invertebrate viruses are orally ingested and commence infection in cells of the invertebrate intestine. Infection of secondary sites and eventual transmission to other hosts is hindered by basal lamina, a tightly interwoven and virus-impenetrable noncellular layer, lining the intestine and other organ cell layers. The mechanisms for viral escape across basal laminae are unknown. We describe an elegant mechanism mediated by a baculovirus-encoded fibroblast growth factor (vFGF) that signals a previously undescribed stepwise cascade of protease activation wherein matrix metalloproteases activate effector caspases, leading to remodeling of basal lamina lining tracheal cells associated with the intestine and culminating in the establishment of efficient systemic infections. Because FGFs coordinate diverse functions during development, metabolic processes, and tissue repair, it is plausible that the vFGF-mediated pathway described here is widely used during developmental and pathogenic processes that involve basal lamina remodeling.
Means
John C
JC
Molecular, Cellular, and Developmental Biology Program, Division of Biology, Kansas State University, Manhattan, KS 66506-4901, USA.
Passarelli
A Lorena
AL
D000818:Animals; D016367:Baculoviridae / Q000235:genetics / Q000502:physiology*; D001485:Basement Membrane / Q000201:enzymology / Q000648:ultrastructure / Q000821:virology; D020169:Caspases / Q000378:metabolism*; D004789:Enzyme Activation; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D007313:Insecta / Q000201:enzymology / Q000821:virology; D008666:Metalloendopeptidases / Q000378:metabolism*; D046529:Microscopy, Electron, Transmission
D005346:Fibroblast Growth Factors; D020169:Caspases; D008666:Metalloendopeptidases
Int J Mol Med. 2007 Oct;20(4):591-5
17786292
J Surg Res. 2009 Jul;155(1):165-72
19394961
J Biochem. 2003 Nov;134(5):739-49
14688240
Development. 2004 Jan;131(1):15-24
14645125
Arch Virol Suppl. 2005;(19):89-100
16355869
Virology. 1995 Jun 1;209(2):561-8
7778288
J Virol. 2006 Jun;80(11):5474-81
16699027
J Med Entomol. 1998 Jul;35(4):567-72
9701946
Virology. 1995 Sep 10;212(1):1-12
7676618
Cell. 1996 Dec 13;87(6):1091-101
8978613
Am J Physiol Cell Physiol. 2003 Apr;284(4):C805-15
12466149
Cell Death Differ. 1998 Dec;5(12):1004-16
9894607
Carcinogenesis. 2004 Jun;25(6):873-9
14729579
Cell Death Differ. 2006 Jul;13(7):1222-34
16322754
Virology. 2007 Aug 15;365(1):70-8
17459443
Virology. 2006 Nov 10;355(1):62-70
16904150
J Gen Virol. 2002 Jul;83(Pt 7):1565-1572
12075074
Apoptosis. 2005 Jan;10(1):19-24
15711919
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3224-7
8159729
Cell. 2008 Mar 7;132(5):818-31
18329368
Virology. 1995 Jun 1;209(2):384-9
7778273
Science. 1991 Nov 29;254(5036):1388-90
1962198
Biochem Biophys Res Commun. 2001 May 25;283(5):1111-7
11355887
J Cereb Blood Flow Metab. 2004 Jul;24(7):720-7
15241180