title: HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis.
abstract: Chlamydia trachomatis sexually transmitted infection can cause serious reproductive morbidities. This study determined the prevalence of a serum IgG response to C. trachomatis putative stress response proteins in women, to test for an association with genital tract pathology. There was no significant association of serum IgG reactive with C. trachomatis HtrA, Tsp, or RseP with infection or pathology. cHSP60 serum IgG prevalence was significantly associated with infection compared to IgG negative infertile controls, but not with upper genital tract pathology. Serum IgG(1-4) antibody subclasses reactive with these antigens was not significantly different between cohorts, although different responses to each antigen were detected.
authors.affiliation: Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, QLD 4053, Australia. w.huston@qut.edu.au
authors.forename: Wilhelmina M
authors.initials: WM
authors.lastname: Huston
authors.forename: Charles W
authors.initials: CW
authors.lastname: Armitage
authors.forename: Amba
authors.initials: A
authors.lastname: Lawrence
authors.forename: Sarina
authors.initials: S
authors.lastname: Gloeckl
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Bell
authors.forename: Joseph
authors.initials: J
authors.lastname: Debattista
authors.forename: John A
authors.initials: JA
authors.lastname: Allan
authors.forename: Peter
authors.initials: P
authors.lastname: Timms
mesh_terms: D001426:Bacterial Proteins / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D018834:Chaperonin 60 / Q000276:immunology; D002690:Chlamydia Infections / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D002692:Chlamydia trachomatis / Q000276:immunology* / Q000472:pathogenicity; D010450:Endopeptidases / Q000276:immunology*; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000097:blood; D015231:Sexually Transmitted Diseases, Bacterial / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D001426:Bacterial Proteins; D015415:Biomarkers; D018834:Chaperonin 60; D006360:Heat-Shock Proteins; D007074:Immunoglobulin G; D010450:Endopeptidases