title: alpha-Glucosidase inhibition properties of cucurbitane-type triterpene glycosides from the fruits of Momordica charantia.
abstract: Fourteen cucurbitane-type triterpene glycosides (1-14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A-C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for alpha-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against alpha-glucosidase. Whereas, 2, 3, 6-11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Ninh Khac
authors.initials: NK
authors.lastname: Ban
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Le Minh
authors.initials: le M
authors.lastname: Ha
authors.forename: Do Thi
authors.initials: do T
authors.lastname: Ha
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Tran Hong
authors.initials: TH
authors.lastname: Quang
authors.forename: Tran Minh
authors.initials: TM
authors.lastname: Ngoc
authors.forename: Young-In
authors.initials: YI
authors.lastname: Kwon
authors.forename: Hae-Dong
authors.initials: HD
authors.lastname: Jang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D007422:Intestines / Q000201:enzymology; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane; D000520:alpha-Glucosidases