Predictors of menstrual resumption by patients with anorexia nervosa.
OBJECTIVE
To investigate which factors predict the resumption of menstruation by patients with anorexia nervosa (AN).


METHODS
Participants were AN patients who, even after weight recovery by inpatient treatment, had prolonged amenorrhea (N=11), AN patients who resumed menstruation after weight recovery (N=9), and age-matched healthy controls (N=12). Anthropometric data and the serum levels of leptin, insulin-like growth factor I (IGF-1), cortisol, luteinizing hormone (LH), estradiol (E2), and other hormones were measured at the beginning of the inpatient treatment and after weight recovery.


RESULTS
Of the baseline anthropometric and hormonal factors, logistic regression analysis extracted a high serum cortisol level as a predictor of the inhibition of the resumption of menstruation. After weight recovery, the E2 and leptin levels were significantly higher for eumenorrheic patients than for amenorrheic patients.


CONCLUSIONS
The baseline serum cortisol level was a predictor of the prolonged inhibition of menstrual recovery.
Arimura
C
C
Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan. chikakok@d2.dion.ne.jp
Nozaki
T
T
Takakura
S
S
Kawai
K
K
Takii
M
M
Sudo
N
N
Kubo
C
C
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D000704:Analysis of Variance; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000097:blood*; D011237:Predictive Value of Tests
D020738:Leptin; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D006854:Hydrocortisone
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