title: [Mechanism of Chinese herbal medicine delaying glomerulosclerosis in diabetic nephropathy].
abstract: The pathomechanisms of glomerulosclerosis in diabetic nephropathy (DN) are considered to be related with glycometabolism disorder, podocyte injury, intra-renal hemodynamics abnormality, fibrogenic cytokines over-expression, oxidative stress and inflammatory reaction. Chinese herbal medicine could delay the progression of glomerulosclerosis in DN by ameliorating the harmful factors of these pathological changes. Therefore, it is possible to postpone the progress of DN to end-stage renal disease through the treatment with Chinese herbal medicine.
authors.affiliation: Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210008, China. ada47@sohu.com
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Yigang
authors.initials: Y
authors.lastname: Wan
authors.forename: Rongwen
authors.initials: R
authors.lastname: Bian
authors.forename: Liubao
authors.initials: L
authors.lastname: Gu
authors.forename: Chaojun
authors.initials: C
authors.lastname: Wang
authors.forename: Huilan
authors.initials: H
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal