title: The effect of creatinine clearance on the short-term outcome of neuropathic diabetic foot ulcers.
abstract: Reduced creatinine clearance is related to an increased risk for diabetic foot ulcer development. Wound healing has been reported to be worse in diabetic patients with impaired kidney functions than general diabetic population. This study aimed to investigate the effect of creatinine clearance on the short-term outcome of neuropathic diabetic foot ulcers. Data from 147 neuropathic diabetic foot ulcer episodes were included in this observational study. Patients were admitted to Dokuz Eylul University Hospital between January 2003 and June 2008. Patients were excluded if they had limb ischemia. Diabetic nephropathy was investigated by 24h urinary albumin excretion and serum creatinine levels. Creatinine clearance was calculated according to Cockcroft-Gault formula. Foot ulcers were followed up for 6 months to determine the outcome. Our short-term follow-up revealed that neuropathic diabetic ulcers healed worse in patients with decreased creatinine clearance than in those who had normal creatinine clearance. Amputation rates were also found to be higher. Our results suggest that creatinine clearance is an important factor affecting wound healing in patients with neuropathic diabetic foot ulcers.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Turkey. baris.akinci@deu.edu.tr
authors.forename: Baris
authors.initials: B
authors.lastname: Akinci
authors.forename: Sena
authors.initials: S
authors.lastname: Yesil
authors.forename: Firat
authors.initials: F
authors.lastname: Bayraktar
authors.forename: Yasin
authors.initials: Y
authors.lastname: Kucukyavas
authors.forename: Serkan
authors.initials: S
authors.lastname: Yener
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Comlekci
authors.forename: Sevinc
authors.initials: S
authors.lastname: Eraslan
mesh_terms: D000671:Amputation, Surgical; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood*; D017719:Diabetic Foot / Q000150:complications / Q000473:pathology / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D003404:Creatinine