Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.
The adaptor protein SLP-76 is expressed in multiple hematopoietic lineages including T cells, platelets, and neutrophils. SLP-76 mediated signaling is dependent on its multiple protein interaction domains, as it creates a scaffold on which key signaling complexes are built. SLP-76 is critical for supporting signaling downstream of both immunoreceptors and integrins. The signaling molecules used both upstream and downstream of SLP-76 are similar among these receptors and across cell types; however, important differences exist. Appreciating how SLP-76 coordinates signal transduction across different cell and receptor types provides insights into the complex interplay of pathways critical for activation of cells of the immune system that are essential for host defense.
Jordan
Martha S
MS
Abramson Family Cancer Institute, University of Pennsylvania, Philadelphia, 19104, USA.
Koretzky
Gary A
GA
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D019070:Cell Lineage; D006413:Hematopoietic System / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D011946:Receptors, Antigen / Q000378:metabolism*; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D011946:Receptors, Antigen; C092947:SLP-76 signal Transducing adaptor proteins
Mol Cell Biol. 2009 Oct;29(20):5578-89
19667077
Mol Cell Biol. 2006 Sep;26(17):6727-38
16914752
Immunity. 1998 Nov;9(5):607-16
9846482
J Biol Chem. 2004 Apr 9;279(15):15481-90
14722089
J Immunol. 2007 Apr 1;178(7):4606-14
17372019
Curr Biol. 1999 Jan 28;9(2):67-75
10021361
Curr Biol. 2001 Nov 13;11(22):1799-804
11719224
Eur J Immunol. 2007 Oct;37(10):2961-72
17823979
Immunity. 2006 Jul;25(1):93-104
16860760
Blood. 2009 Jul 2;114(1):74-84
19401562
J Immunol. 2009 Nov 1;183(9):5756-67
19812192
J Immunol. 2001 May 1;166(9):5654-64
11313406
J Immunol. 1999 Sep 15;163(6):3143-52
10477581
J Exp Med. 2007 Mar 19;204(3):681-91
17353368
Immunity. 2008 Mar;28(3):359-69
18342008
J Biol Chem. 2001 Nov 30;276(48):45207-16
11487585
Science. 1998 Jul 17;281(5375):416-9
9665885
J Biol Chem. 1997 May 2;272(18):11674-7
9115214
Mol Cell Biol. 2006 Sep;26(18):6936-49
16943434
J Immunol. 2003 Aug 1;171(3):1360-8
12874226
Immunity. 2008 Jun;28(6):810-21
18549800
J Biol Chem. 1996 Aug 16;271(33):19641-4
8702662
J Biol Chem. 2005 Mar 4;280(9):8364-70
15623534
J Immunol. 2004 Jun 1;172(11):6768-74
15153494
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):884-9
11792851
J Clin Invest. 1999 Jan;103(1):19-25
9884330
Curr Biol. 2002 Aug 6;12(15):1336-41
12176364
Immunity. 2003 Nov;19(5):761-9
14614862
J Allergy Clin Immunol. 2009 Nov;124(5):1088-98
19895996
Curr Biol. 2003 Sep 16;13(18):1619-24
13678593
J Exp Med. 2005 Oct 3;202(7):893-900
16186188
Mol Cell Biol. 2006 Oct;26(19):7155-66
16980618
Nat Struct Mol Biol. 2006 Sep;13(9):798-805
16906159
Nat Immunol. 2006 Dec;7(12):1326-33
17086186
J Biol Chem. 1997 Oct 3;272(40):25401-8
9312162
Cell. 1998 Jan 9;92(1):83-92
9489702
Science. 1998 Jul 17;281(5375):413-6
9665884
Eur J Immunol. 1999 Nov;29(11):3702-11
10556826
Nat Immunol. 2007 Jan;8(1):84-91
17115060
J Biol Chem. 1995 Mar 31;270(13):7029-32
7706237
Cell. 1998 Jul 24;94(2):229-38
9695951
Mol Cell Biol. 2001 Jul;21(13):4208-18
11390650
Science. 2003 Jan 10;299(5604):247-51
12522250
J Clin Invest. 1999 Jun;103(12):1737-43
10377180
J Immunol. 2005 Feb 1;174(3):1385-92
15661896
J Biol Chem. 1998 Dec 18;273(51):34437-43
9852111
J Biol Chem. 2007 Feb 2;282(5):2937-46
17148460
J Exp Med. 1999 May 3;189(9):1383-90
10224278
Immunity. 2000 Apr;12(4):399-408
10795738
Science. 2001 Sep 21;293(5538):2260-3
11567140
Mol Cell Biol. 2006 Oct;26(19):7130-44
16980616
Immunity. 2006 Jul;25(1):79-91
16860759
J Thromb Haemost. 2008 Dec;6(12):2152-9
18826392
Immunity. 1997 Feb;6(2):155-64
9047237
J Biol Chem. 2000 Jan 21;275(3):2219-30
10636929
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12056-61
11050236
J Exp Med. 2002 Mar 18;195(6):705-17
11901197
Immunol Rev. 2007 Aug;218:9-28
17624941
Immunity. 2001 Dec;15(6):1011-26
11754821
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19063-8
16354835
Science. 2001 Sep 21;293(5538):2263-5
11567141
J Exp Med. 2004 Oct 18;200(8):1063-74
15477347
Mol Cell Biol. 2007 Jun;27(11):4070-81
17403904
J Exp Med. 2008 Aug 4;205(8):1775-88
18663126
Immunity. 1996 Jun;4(6):593-602
8673706
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6638-43
17420479
J Immunol. 1997 Aug 15;159(4):1639-47
9257823
J Exp Med. 2002 May 6;195(9):1103-14
11994416