title: Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans.
abstract: The Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has provided clinical, operational, and data management support to ADNI since its inception. This article reviews the activities and accomplishments of the core in support of ADNI aims. These include the enrollment and follow-up of more than 800 subjects in the three original cohorts: healthy controls, amnestic mild cognitive impairment (now referred to as late MCI, or LMCI), and mild Alzheimer's disease (AD) in the first phase of ADNI (ADNI 1), with baseline longitudinal, clinical, and cognitive assessments. These data, when combined with genetic, neuroimaging, and cerebrospinal fluid measures, have provided important insights into the neurobiology of the AD spectrum. Furthermore, these data have facilitated the development of novel clinical trial designs. ADNI has recently been extended with funding from an NIH Grand Opportunities (GO) award, and the new ADNI GO phase has been launched; this includes the enrollment of a new cohort, called early MCI, with milder episodic memory impairment than the LMCI group. An application for a further 5 years of ADNI funding (ADNI 2) was recently submitted. This funding would support ongoing follow-up of the original ADNI 1 and ADNI GO cohorts, as well as additional recruitment into all categories. The resulting data would provide valuable data on the earliest stages of AD, and support the development of interventions in these critically important populations.
authors.affiliation: Department of Neurosciences, University of California San Diego, CA, USA. paisen@ucsd.edu
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Michael C
authors.initials: MC
authors.lastname: Donohue
authors.forename: Anthony
authors.initials: A
authors.lastname: Gamst
authors.forename: Rema
authors.initials: R
authors.lastname: Raman
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Thomas
authors.forename: Sarah
authors.initials: S
authors.lastname: Walter
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Shaw
authors.forename: Laurel A
authors.initials: LA
authors.lastname: Beckett
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: William
authors.initials: W
authors.lastname: Jagust
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Saykin
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000473:pathology; D003952:Diagnostic Imaging; D018450:Disease Progression; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D016730:Program Development; D011877:Radionuclide Imaging
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