title: Aminocatalytic asymmetric inverse-electron-demand aza-Diels-Alder reaction of N-Ts-1-aza-1,3-butadienes based on coumarin cores.
abstract: The asymmetric inverse-electron-demand aza-Diels-Alder reaction of N-Ts-1-aza-1,3-butadienes derived from 3-argiocarbonylcoumarins and acetaldehyde has been developed using chiral secondary aminocatalysis, giving tricyclic chroman-2-one derivatives in high enantioselectivities (up to 95% ee).
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Jun-Long
authors.initials: JL
authors.lastname: Li
authors.forename: Si-Li
authors.initials: SL
authors.lastname: Zhou
authors.forename: Bo
authors.initials: B
authors.lastname: Han
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000079:Acetaldehyde / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D002070:Butadienes / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004583:Electrons; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D002070:Butadienes; D003374:Coumarins; C030123:coumarin; D000079:Acetaldehyde; C031763:1,3-butadiene