Adhesion molecules in the stem cell niche--more than just staying in shape?
The expression of adhesion molecules by stem cells within their niches is well described, but what is their function? A conventional view is that these adhesion molecules simply retain stem cells in the niche and thereby maintain its architecture and shape. Here, we review recent literature showing that this is but one of their roles, and that they have essential functions in all aspects of the stem cell-niche interaction--retention, division and exit. We also highlight from this literature evidence supporting a simple model whereby the regulation of centrosome positioning and spindle angle is regulated by both cadherins and integrins, and the differential activity of these two adhesion molecules enables the fundamental stem cell property of switching between asymmetrical and symmetrical divisions.
Marthiens
Véronique
V
Institut Curie, UMR144, Paris, France.
Kazanis
Ilias
I
Moss
Lara
L
Long
Katherine
K
Ffrench-Constant
Charles
C
D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D048750:Cell Nucleus Division; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008954:Models, Biological; D055153:Stem Cell Niche / Q000378:metabolism* / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology
D015820:Cadherins; D016023:Integrins
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