Vascular potential of human pluripotent stem cells.
Cardiovascular disease is the number one cause of death and disability in the US. Understanding the biological activity of stem and progenitor cells, and their ability to contribute to the repair, regeneration and remodeling of the heart and blood vessels affected by pathological processes is an essential part of the paradigm in enabling us to achieve a reduction in related deaths. Both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are promising sources of cells for clinical cardiovascular therapies. Additional in vitro studies are needed, however, to understand their relative phenotypes and molecular regulation toward cardiovascular cell fates. Further studies in translational animal models are also needed to gain insights into the potential and function of both human ES- and iPS-derived cardiovascular cells, and enable translation from experimental and preclinical studies to human trials.
Iacobas
Ionela
I
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Vats
Archana
A
Hirschi
Karen K
KK
D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000601:surgery; D002454:Cell Differentiation; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000502:physiology* / Q000637:transplantation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology; D018919:Neovascularization, Physiologic; D010641:Phenotype; D039904:Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000502:physiology
Development. 2004 Nov;131(22):5515-25
15509763
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4736-41
12682294
Dev Biol. 1992 Jul;152(1):75-88
1321062
Blood. 2008 Feb 15;111(4):1933-41
18042803
Nature. 2009 Apr 9;458(7239):766-70
19252478
Circ Res. 2007 Jun 22;100(12):1686-95
17585076
Nature. 2007 Jul 19;448(7151):313-7
17554338
Stem Cells. 2007 Sep;25(9):2206-14
17556598
Mech Dev. 1997 Nov;68(1-2):3-25
9431800
Circulation. 2008 Jul 29;118(5):498-506
18625891
Dev Dyn. 2010 Apr;239(4):1178-87
20235229
Genes Dev. 2001 Sep 15;15(18):2470-82
11562355
Stem Cells. 2009 May;27(5):1042-9
19415770
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):814-9
19129488
Nat Biotechnol. 2008 Aug;26(8):916-24
18594521
Dev Biol. 2005 Jul 1;283(1):140-56
15882861
Arterioscler Thromb Vasc Biol. 2009 May;29(5):718-24
19213939
Dev Biol. 2004 May 15;269(2):360-80
15110706
Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2127-34
17872458
Development. 1996 May;122(5):1363-71
8625825
Curr Opin Lipidol. 2006 Oct;17(5):548-55
16960504
Development. 1991 Nov;113(3):891-911
1821858
Reprod Biomed Online. 2006 Oct;13(4):551-7
17007678
Cell. 2006 Aug 25;126(4):663-76
16904174
Int J Dev Biol. 1998;42(7):917-25
9853822
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2975-80
14978268
Nat Biotechnol. 2001 Oct;19(10):971-4
11581665
Mol Cell Biol. 1995 Jan;15(1):141-51
7799920
Cell Stem Cell. 2008 May 8;2(5):497-507
18462699
PLoS One. 2009;4(3):e4994
19308258
Science. 1998 Nov 6;282(5391):1145-7
9804556
Science. 2009 May 8;324(5928):797-801
19325077
Immunol Today. 1994 Oct;15(10):490-5
7945775
Glia. 2005 Feb;49(3):385-96
15538751
Blood. 2005 Aug 1;106(3):860-70
15831705
Nat Biotechnol. 2008 Jan;26(1):101-6
18059259
J Embryol Exp Morphol. 1985 Jun;87:27-45
3897439
Dev Biol. 1999 Aug 15;212(2):307-22
10433823
Dev Biol. 1999 Feb 15;206(2):123-41
9986727
Gastroenterology. 1994 Apr;106(4):1106-11
8143978
J Hematother Stem Cell Res. 2001 Oct;10(5):587-94
11672504
Immunity. 2004 Jul;21(1):31-41
15345218
Nat Methods. 2006 Aug;3(8):637-46
16862139
Stem Cells. 2009 Nov;27(11):2667-74
19697349
Development. 2002 Jan;129(2):361-72
11807029
Differentiation. 2004 Jun;72(5):230-8
15270779
Genes Dev. 1995 Sep 1;9(17):2105-16
7657163
Vasc Med. 2009 May;14(2):153-66
19366823
Development. 1998 Jul;125(14):2611-20
9636076
Cell. 2009 Mar 6;136(5):964-77
19269371
Science. 1984 Mar 23;223(4642):1296-9
6199844
Blood. 1996 Jan 15;87(2):630-41
8555485
Am J Pathol. 2005 Sep;167(3):663-71
16127147
Mol Cell Biol. 2000 Aug;20(15):5643-52
10891501
Blood. 2005 Jan 15;105(2):617-26
15374881
Dev Biol. 2006 Jun 15;294(2):458-70
16678147
Mol Cell Biol. 2007 Apr;27(7):2687-97
17242194
Mol Cell Biol. 1995 Nov;15(11):5957-65
7565748
Immunity. 1998 Oct;9(4):555-63
9806641
EMBO J. 1998 Jul 15;17(14):4029-45
9670018
Circ Res. 2009 Feb 27;104(4):e30-41
19213953
Nature. 1989 Jun 8;339(6224):446-51
2725678
Cell Stem Cell. 2009 May 8;4(5):381-4
19398399
Blood. 2008 May 1;111(9):4500-10
18270322
Science. 1994 Aug 19;265(5175):1098-101
8066449
Stem Cells Dev. 2010 Nov;19(11):1757-67
20192839
Development. 2001 Jan;128(2):155-66
11124112
J Cell Sci. 2006 Feb 15;119(Pt 4):759-68
16449320
Mech Dev. 1997 Mar;62(2):197-211
9152011
Blood. 2003 Aug 1;102(3):906-15
12702499
Nature. 1996 Apr 4;380(6573):435-9
8602241
Dev Dyn. 1998 Dec;213(4):421-30
9853963
Hum Mol Genet. 2006 Jul 1;15(13):2098-105
16723375
Stem Cells. 2009 Mar;27(3):559-67
19259936
Nature. 1995 Jul 6;376(6535):62-6
7596435
J Cell Mol Med. 2011 Jan;15(1):38-51
20041972
Genes Dev. 1999 Aug 15;13(16):2072-86
10465785
Hum Reprod. 2009 Oct;24(10):2567-81
19556288
Nat Methods. 2007 Jun;4(6):501-9
17486087
Stem Cells. 2008 Jun;26(6):1537-46
18450826
Circulation. 2008 Jul 29;118(5):507-17
18625890
Cell. 2007 Nov 30;131(5):861-72
18035408
J Embryol Exp Morphol. 1975 Aug;34(1):125-54
1185098
Science. 2008 Nov 7;322(5903):949-53
18845712
J Biol Chem. 2004 Aug 13;279(33):34741-9
15184386
Development. 2007 Oct;134(20):3753-61
17881493
Cell. 2008 Dec 12;135(6):1053-64
19070576
Nat Rev Drug Discov. 2007 Apr;6(4):273-86
17396134
Br J Haematol. 1991 Oct;79 Suppl 1:67-8
1931713
Development. 2002 Sep;129(17):4147-57
12163416
Cancer Treat Res. 2004;117:3-32
15015550
Dev Biol. 2007 Mar 15;303(2):772-83
17125762
Stem Cells. 2006 Aug;24(8):1923-30
16675598
Circulation. 1999 Apr 6;99(13):1726-32
10190883
Cell. 1997 Jun 13;89(6):981-90
9200616
Development. 1994 Sep;120(9):2539-53
7956830
Development. 2007 Jan;134(2):393-405
17166922
Blood. 1994 Mar 1;83(5):1200-8
8118024
PLoS One. 2009 Dec 31;4(12):e8443
20046878
Am J Pathol. 1994 Sep;145(3):574-84
7521577
Immunity. 2000 Aug;13(2):167-77
10981960
Am J Pathol. 1997 May;150(5):1523-30
9137078
Stem Cells. 2008 Mar;26(3):724-33
18096723
J Cell Physiol. 1997 Nov;173(2):206-10
9365523
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4391-6
11917100
Nature. 2009 Apr 9;458(7239):771-5
19252477
PLoS One. 2008 Jun 11;3(6):e2401
18545664
Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1100-3
19423866
Development. 2001 May;128(10):1717-30
11311154
EMBO J. 1997 Jul 16;16(14):4374-83
9250681
J Craniofac Genet Dev Biol. 1991 Oct-Dec;11(4):192-213
1812125
Science. 2007 Dec 21;318(5858):1917-20
18029452
Nature. 2004 Jul 15;430(6997):350-6
15254537
Stem Cells. 2009 Jan;27(1):59-67
18845766
Mech Dev. 2000 Jun;94(1-2):117-32
10842064
Dev Biol. 1997 Jul 15;187(2):298-310
9242425
Nucleic Acids Res. 2004 Oct 21;32(18):5693-702
15498926