title: Neuropathic pain in breast cancer survivors: using the ID pain as a screening tool.
abstract: Neuropathic pain (NP) is a debilitating symptom experienced by a number of patients with cancer. We evaluated the validity of ID Pain as a screening tool for NP in breast cancer survivors using the Self-Report Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) and a reported diagnosis of NP as criterion measures. Two hundred forty breast cancer survivors with a mean age of 58 years (standard deviation=16) participated in this survey. Forty-five percent of the sample reported having pain in the past week. Of those reporting pain, 33% reported that they had been diagnosed by their health care provider with NP, 39% had a positive ID Pain (> or = 2) score, and 19% had a positive S-LANSS score. The most commonly endorsed ID Pain item was "hot/burning" (n=48) followed by feeling "numb" (n=47) and "pins and needles" (n=45). Total ID Pain score was significantly associated with a clinical diagnosis of NP (r=0.41; P<0.001) and the S-LANSS total score (r=0.54; P<0.001). Receiver operating curve analysis demonstrated that ID Pain has a predictive validity of 0.72 and 0.70 for diagnosis of NP as made by clinicians and the S-LANSS, respectively. We also found that an ID Pain score greater than or equal to 2 corresponded with the likelihood of NP in this sample, consistent with the original ID Pain development study. This study provides evidence for ID Pain as a valid screening measure for NP in breast cancer survivors.
authors.affiliation: Department of Epidemiology, Division of Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. creyes@mdanderson.org
authors.forename: Cielito
authors.initials: C
authors.lastname: Reyes-Gibby
authors.forename: Phuong Khanh
authors.initials: PK
authors.lastname: Morrow
authors.forename: Michael I
authors.initials: MI
authors.lastname: Bennett
authors.forename: Mark P
authors.initials: MP
authors.lastname: Jensen
authors.forename: Sanjay
authors.initials: S
authors.lastname: Shete
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009437:Neuralgia / Q000175:diagnosis* / Q000209:etiology; D016017:Odds Ratio; D010147:Pain Measurement; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D017741:Survivors
references.citation: Curr Neuropharmacol. 2006 Apr;4(2):165-72
references.pmid: 18615126
references.citation: Int J Fertil Womens Med. 2006 Mar-Apr;51(2):75-82
references.pmid: 16881383
references.citation: Br J Cancer. 2005 Jan 31;92(2):225-30
references.pmid: 15655557
references.citation: Acta Oncol. 1997;36(6):625-30
references.pmid: 9408154
references.citation: Breast. 2008 Oct;17(5):472-6
references.pmid: 18450444
references.citation: Neurology. 2008 Apr 29;70(18):1630-5
references.pmid: 18003941
references.citation: Neurology. 1997 Feb;48(2):332-8
references.pmid: 9040716
references.citation: Clin J Pain. 2003 Sep-Oct;19(5):315-6
references.pmid: 12966257
references.citation: Pain. 2001 May;92(1-2):147-57
references.pmid: 11323136
references.citation: Pain. 1999 Jan;79(1):15-20
references.pmid: 9928771
references.citation: Clin J Pain. 2003 Sep-Oct;19(5):306-14
references.pmid: 12966256
references.citation: Eur J Neurol. 2008 Aug;15(8):851-7
references.pmid: 18565107
references.citation: Eur J Pain. 2009 May;13(5):478-85
references.pmid: 18635381
references.citation: J R Soc Med. 2003 Aug;96(8):379-83
references.pmid: 12893852
references.citation: Pain. 2000 Sep;87(3):275-284
references.pmid: 10963907
references.citation: J Pain. 2008 Sep;9(9):813-22
references.pmid: 18585963
references.citation: Pain Suppl. 1986;3:S1-226
references.pmid: 3461421
references.citation: Pain. 2007 Feb;127(3):199-203
references.pmid: 17182186
references.citation: Curr Pain Headache Rep. 2006 Jun;10(3):159-66
references.pmid: 18778569
references.citation: Acta Anaesthesiol Scand. 2009 Jul;53(6):800-6
references.pmid: 19397505
references.citation: J Pain. 2006 Sep;7(9):626-34
references.pmid: 16942948
references.citation: Pain. 2005 Nov;118(1-2):10-4
references.pmid: 16213086
references.citation: Pain. 2005 Mar;114(1-2):29-36
references.pmid: 15733628
references.citation: Curr Med Res Opin. 2006 Aug;22(8):1555-65
references.pmid: 16870080
references.citation: Pain Pract. 2007 Jun;7(2):163-77
references.pmid: 17559487
references.citation: Cancer. 2008 Dec 15;113(12 Suppl):3530-9
references.pmid: 19058147
references.citation: J Pain. 2009 Jun;10(6):594-600
references.pmid: 19231297
references.citation: J Pain. 2005 Mar;6(3):149-58
references.pmid: 15772908
references.citation: Disabil Rehabil. 2004 Jan 21;26(2):78-84
references.pmid: 14668143
references.citation: Breast Cancer. 2006;13(2):197-201
references.pmid: 16755117
references.citation: Ann Oncol. 1995 May;6(5):453-9
references.pmid: 7669710
references.citation: Pain. 1999 Sep;82(3):263-274
references.pmid: 10488677
references.citation: Oncology. 2003;65(1):23-8
references.pmid: 12837979
references.citation: Pain. 2004 Jul;110(1-2):461-9
references.pmid: 15275799
references.citation: Int J Radiat Oncol Biol Phys. 2003 Mar 1;55(3):651-8
references.pmid: 12573752