Efficient in situ three-component formation of chiral oxazoline-Schiff base copper(II) complexes: towards combinatorial library of chiral catalysts for asymmetric Henry reaction.
A combinatorial in situ three-component chiral oxazoline-Schiff base copper(II) complex catalyst formation method was developed. This simple combinatorial chiral catalyst approach provided a modular library of chiral oxazoline-Schiff base copper(II) complex catalysts. The catalytic activity of these in situ generated catalysts can be rapidly and conveniently evaluated in the asymmetric Henry reaction. Moderate to good yields and enantioselectivities (up to 92% ee) were obtained under the optimized condition. The combination of modular three-component catalyst formation and in situ asymmetric reaction provides a new technology in asymmetric catalysis.
Yang
Wen
W
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
Liu
Han
H
Du
Da-Ming
DM
D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000438:Alcohols; D009942:Organometallic Compounds; D010080:Oxazoles; D012545:Schiff Bases; D003300:Copper