title: The use of click chemistry in the emerging field of catalomics.
abstract: Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore117543.
authors.forename: Karunakaran A
authors.initials: KA
authors.lastname: Kalesh
authors.forename: Haibin
authors.initials: H
authors.lastname: Shi
authors.forename: Jingyan
authors.initials: J
authors.lastname: Ge
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods* / Q000639:trends
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes