title: Acute inflammatory syndrome and intrahepatic cholestasis caused by an interleukin-6-producing pheochromocytoma with pregnancy.
abstract: We herein describe the case of a 30-year-old woman who experienced high fever during the puerperal period and was diagnosed with pheochromocytoma. Acute inflammatory syndrome, as indicated by the elevated serum levels of interleukin-6 (IL-6), and cholestatic liver dysfunction were observed. Since this condition resolved before the operation, it was probably caused by massive central necrosis within the tumor. The IL-6 production from the tumor cells was confirmed by immunohistochemistry. When a case of pheochromocytoma accompanied with acute inflammatory syndrome is encountered, the possibility that the tumor itself might produce some cytokines should be considered, even in the presence of massive necrosis within the tumor.
authors.affiliation: Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Nagaishi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akehi
authors.forename: Kenji
authors.initials: K
authors.lastname: Ashida
authors.forename: Kazuna
authors.initials: K
authors.lastname: Higuchi-Tubouchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nojiri
authors.forename: Mikiko
authors.initials: M
authors.lastname: Aoki
authors.forename: Keizo
authors.initials: K
authors.lastname: Anzai
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Junko
authors.initials: J
authors.lastname: Ono
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D010673:Pheochromocytoma / Q000150:complications*; D011247:Pregnancy; D011644:Puerperal Disorders; D013577:Syndrome