title: Evidence-based consensus recommendations to improve the quality of life in prostate cancer treatment.
abstract: BACKGROUND
  Prostate cancer (PC) is one of the tumours with the highest incidence in recent years. PC therapies have several adverse effects. A panel consensus recommendation has been made to prevent or ameliorate complications in PC treatment to improve quality of life.
  
  
  METHODS
  Fifteen specialists have met to analyse the different toxicities associated with PC treatment. Each medical specialist performed a National Library of Medicine PubMed search citations searching about these secondary effects and his specialty from 1999 to 2009 to propose measures for their prevention/amelioration.
  
  
  RESULTS
  Surgery is associated with incontinence and impotence. Radiotherapy can produce acute, late urological and gastrointestinal toxicity. Brachytherapy can produce acute urinary retention. Chemotherapy is associated with haematotoxicity, peripheral neuropathy and diarrhoea, and hormone therapy can produce osteoporosis, metabolic syndrome, cognitive and muscular alterations, cardiotoxicity, etc.
  
  
  CONCLUSIONS
  Improvement in surgical techniques and technology (IMRT/IGRT) can prevent surgical and radiotherapeutic toxicity, respectively. Brachytherapy toxicity can be prevented with precise techniques to preserve the urethra. Chemotherapy toxicity can be prevented with personalized schedules of treatment and close follow-up of iatrogenia and hormone therapy toxicity can be prevented with close follow-up of possible secondary effects.
authors.affiliation: Radiation Oncology Department, Hospital Clínic, Barcelona, Spain. fcasas@clinic.ub.es
authors.forename: Francesc
authors.initials: F
authors.lastname: Casas
authors.forename: Josep María
authors.initials: JM
authors.lastname: Borràs
authors.forename: Ferran
authors.initials: F
authors.lastname: Ferrer
authors.forename: Núria
authors.initials: N
authors.lastname: Guanyabens
authors.forename: Rafael
authors.initials: R
authors.lastname: Gutiérrez del Pozo
authors.forename: Concha
authors.initials: C
authors.lastname: León
authors.forename: José
authors.initials: J
authors.lastname: López Torrecilla
authors.forename: Begoña
authors.initials: B
authors.lastname: Mellado
authors.forename: Joan
authors.initials: J
authors.lastname: Morote
authors.forename: Manel
authors.initials: M
authors.lastname: Puig
authors.forename: María José
authors.initials: MJ
authors.lastname: Ribal
authors.forename: Carme
authors.initials: C
authors.lastname: Ruscalleda
authors.forename: Agustí
authors.initials: A
authors.lastname: Serra
authors.forename: Valentí
authors.initials: V
authors.lastname: Valls
authors.forename: Almudena
authors.initials: A
authors.lastname: Zapatero
mesh_terms: D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001918:Brachytherapy / Q000379:methods; D002277:Carcinoma / Q000523:psychology / Q000628:therapy*; D003131:Combined Modality Therapy; D055317:Evidence-Based Practice; D006287:Health Planning Guidelines; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D011832:Radiation Injuries / Q000517:prevention & control / Q000523:psychology; D011879:Radiotherapy Dosage
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