title: [Characteristics of gastroduodenal ulcers in patients with negative biopsies for Helicobacter pylori].
abstract: OBJECTIVE
  To evaluate the clinical, epidemiological and endoscopic characteristics of the Helicobacter pylori (Hp) negative peptic ulcer disease.
  
  
  METHODS
  In this cross sectional study we included 651 patients diagnosed of peptic ulcer disease between January 2000 and December 2005. The diagnosis of Hp infection was established by histology. Clinical and epidemiological characteristics of patients with and without Hp infection were compared.
  
  
  RESULTS
  Males prevailed (69%). Hp negative ulcers were older (57.73 +/- 19.44 years old vs 50.26 +/- 18, 64 years old, P < 0.001). Clinical characteristics did not differ among both groups. Duodenal ulcer prevailed in Hp positive patients (56.5%) and gastric ulcer in Hp negative patients (53.5%). Multiple ulcers and intestinal metaplasia were more frequently found in Hp negative cases [9.3% vs 4.5% (P = 0.015) and 34.5% vs 22.1% (P = 0.001), respectively]. CONCLUSION. Hp negative peptic ulcer disease is found in older patients, with a higher frequency of gastric ulcers, multiple lesions and intestinal metaplasia.
authors.affiliation: Servicio de Gastroenterogía, Hospital Daniel A. Carrión, Callao, Perú pedromontes25@hotmail.com
authors.forename: Pedro Montes
authors.initials: PM
authors.lastname: Teves
authors.forename: Sonia Salazar
authors.initials: SS
authors.lastname: Ventura
authors.forename: Eduardo Monge
authors.initials: EM
authors.lastname: Salgado
mesh_terms: D000368:Aged; D001706:Biopsy; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D013276:Stomach Ulcer / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*