Quantitative analysis of arterial spin labeling FMRI data using a general linear model.
Arterial spin labeling techniques can yield quantitative measures of perfusion by fitting a kinetic model to difference images (tagged-control). Because of the noisy nature of the difference images investigators typically average a large number of tagged versus control difference measurements over long periods of time. This averaging requires that the perfusion signal be at a steady state and not at the transitions between active and baseline states in order to quantitatively estimate activation induced perfusion. This can be an impediment for functional magnetic resonance imaging task experiments. In this work, we introduce a general linear model (GLM) that specifies Blood Oxygenation Level Dependent (BOLD) effects and arterial spin labeling modulation effects and translate them into meaningful, quantitative measures of perfusion by using standard tracer kinetic models. We show that there is a strong association between the perfusion values using our GLM method and the traditional subtraction method, but that our GLM method is more robust to noise.
Hernandez-Garcia
Luis
L
Functional MRI laboratory, University of Michigan, MI 48109, USA. hernan@umich.edu
Jahanian
Hesamoddin
H
Rowe
Daniel B
DB
D000328:Adult; D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
D013113:Spin Labels
Neuroimage. 2005 Jan 1;24(1):207-15
15588612
Radiology. 2009 May;251(2):476-84
19401575
Neuroimage. 2006 Oct 15;33(1):103-14
16860577
Magn Reson Med. 2002 Aug;48(2):242-54
12210932
Magn Reson Med. 2008 Dec;60(6):1488-97
19025913
Neuroimage. 2002 May;16(1):269-82
11969334
Magn Reson Med. 2006 Oct;56(4):891-906
16964610
Neuroimage. 2007 Aug 15;37(2):430-9
17590353
Zhongguo Yi Liao Qi Xie Za Zhi. 2005 Nov;29(6):410-3
16494051
Magn Reson Med. 2005 Sep;54(3):507-12
16086319
Neuroimage. 2002 Mar;15(3):488-500
11848692
Magn Reson Med. 2004 Sep;52(3):679-82
15334591
Magn Reson Med. 2004 Mar;51(3):577-85
15004800
Radiology. 2009 Mar;250(3):856-66
19164119
Magn Reson Imaging. 2008 Sep;26(7):870-3
18501544
J Cereb Blood Flow Metab. 1996 Nov;16(6):1236-49
8898697
Neurology. 2007 Oct 23;69(17):1650-6
17954780
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):212-6
1729691
Curr Opin Neurol. 2009 Aug;22(4):348-55
19491678
Hum Brain Mapp. 2001 May;13(1):1-12
11284042
Neuroimage. 2006 May 15;31(1):376-85
16427324