Biosynthesis of polyketides by trans-AT polyketide synthases.
This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
Piel
Jörn
J
Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Bonn, Germany. joern.piel@uni-bonn.de
D001688:Biological Products / Q000096:biosynthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*; D013237:Stereoisomerism
D001688:Biological Products; D007783:Lactones; D018942:Macrolides; D048630:Polyketide Synthases; C036969:myxovirescin A