Serum selenium concentration is associated with metabolic factors in the elderly: a cross-sectional study.
BACKGROUND
Selenium is an essential micronutrient known for its antioxidant function. However, the association of serum selenium with lipid profiles and fasting glucose are inconsistent in populations with average intake of selenium. Furthermore, there were few studies conducted specifically for the elderly. This study examined the relationship of serum selenium concentration with serum lipids and fasting glucose in the Taiwanese elderly population.


METHODS
This was a cross-sectional study of 200 males and females aged 65-85 years (mean 71.5 +/- 4.6 years) from Taipei, Taiwan. Serum selenium was measured by inductively coupled plasma-mass spectrometer. The association between serum selenium and metabolic factors was examined using a multivariate linear regression analysis after controlling several confounders.


RESULTS
The mean serum selenium concentration was 1.14 mumol/L, without significant difference between sexes. Total cholesterol, triglycerides, and LDL cholesterol increased significantly with serum selenium concentration (P < 0.001, P < 0.05 and P < 0.001, respectively) after adjusting for age, gender, anthropometric indices, lifestyle factors, and cardio-vascular risk factors in several linear regression models. Furthermore, there was a significantly positive association between serum selenium and serum fasting glucose concentrations (P < 0.05).


CONCLUSIONS
Total cholesterol, triglycerides, and LDL cholesterol, and fasting serum glucose concentrations increased significantly with serum selenium concentration in the Taiwanese elderly. The underlying mechanism warrants further research.
Yang
Kuen-Cheh
KC
Department of Family Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan. bretthuang@ntu.edu.tw.
Lee
Long-Teng
LT
Lee
Yow-Shan
YS
Huang
Hui-Ying
HY
Chen
Ching-Yu
CY
Huang
Kuo-Chin
KC
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