title: Monoclonal gammopathy associated with multiple myeloma and visceral leishmaniasis in the dog: a comparison of two cases.
abstract: The term monoclonal gammopathy (MG) suggests the presence of clonal immunoglobulins in blood serum that are recognized as narrow spikes in the beta and/or gamma region of the electrophoretic pattern of serum. In the dog, MG is rare and is associated with a heterogeneous group of diseases that include multiple myeloma (the most common source of MG) as well as infectious and chronic inflammatory diseases such as Leishmaniasis. In this paper, two cases of MG are described: the first case is associated with multiple myeloma of monoclonal component type IgA/lambda, with the latter rare in dogs, and the second case involves MG that developed 3 years after an initial diagnosis of Leishmaniasis.
authors.affiliation: Department of Pathology, Diagnostic and Veterinary Clinic, University of Perugia, Perugia, Italy. mariateresa.antognoni@unipg.it
authors.forename: M T
authors.initials: MT
authors.lastname: Antognoni
authors.forename: F
authors.initials: F
authors.lastname: Birettoni
authors.forename: A
authors.initials: A
authors.lastname: Miglio
authors.forename: P
authors.initials: P
authors.lastname: Lalli
authors.forename: F
authors.initials: F
authors.lastname: Porciello
authors.forename: V
authors.initials: V
authors.lastname: Mangili Pecci
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D007070:Immunoglobulin A / Q000097:blood / Q000145:classification / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000662:veterinary*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000662:veterinary*; D010265:Paraproteinemias / Q000150:complications / Q000662:veterinary*
chemical_list: D007070:Immunoglobulin A
references.citation: J Am Vet Med Assoc. 1986 Jun 1;188(11):1288-92
references.pmid: 3721983
references.citation: Can Vet J. 2008 Jul;49(7):694-702
references.pmid: 18827847
references.citation: J Vet Intern Med. 1994 May-Jun;8(3):233-5
references.pmid: 8064662
references.citation: J Am Anim Hosp Assoc. 1998 Mar-Apr;34(2):121-8
references.pmid: 9507424
references.citation: N Z Vet J. 1991 Dec;39(4):139-44
references.pmid: 16031641
references.citation: J Vet Intern Med. 2004 Sep-Oct;18(5):618-24
references.pmid: 15515575
references.citation: J Vet Intern Med. 2004 Jan-Feb;18(1):119-21
references.pmid: 14765743
references.citation: J Am Anim Hosp Assoc. 2002 Mar-Apr;38(2):135-47
references.pmid: 11908831
references.citation: Infez Med. 2008 Sep;16(3):173-4
references.pmid: 18843217
references.citation: Neth J Med. 2006 Feb;64(2):50-1
references.pmid: 16517989
references.citation: Vet Clin Pathol. 2002;31(2):83-9
references.pmid: 12040490