title: Pinostrobin from Cajanus cajan (L.) Millsp. inhibits sodium channel-activated depolarization of mouse brain synaptoneurosomes.
abstract: This investigation focuses on the in vitro neuroactive properties of pinostrobin, a substituted flavanone from Cajanus cajan (L.) Millsp. of the Fabaceae family. We demonstrate that pinostrobin inhibits voltage-gated sodium channels of mammalian brain (IC(50)=23 µM) based on the ability of this substance to suppress the depolarizing effects of the sodium channel-selective activator veratridine in a synaptoneurosomal preparation from mouse brain. The resting membrane potential of synaptoneurosomes was unaffected by pinostrobin. The pharmacological profile of pinostrobin resembles that of depressant drugs that block sodium channels.
authors.affiliation: Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada. nicholso@sfu.ca
authors.forename: Russell A
authors.initials: RA
authors.lastname: Nicholson
authors.forename: Laurence S
authors.initials: LS
authors.lastname: David
authors.forename: Rui Le
authors.initials: RL
authors.lastname: Pan
authors.forename: Xin Min
authors.initials: XM
authors.lastname: Liu
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D036561:Cajanus / Q000737:chemistry*; D044950:Flavanones / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009465:Neuromuscular Agents / Q000494:pharmacology; D018515:Plant Leaves; D026941:Sodium Channel Blockers / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects*; D013574:Synaptosomes / Q000187:drug effects / Q000502:physiology; D014701:Veratridine / Q000494:pharmacology
chemical_list: D044950:Flavanones; D009465:Neuromuscular Agents; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D014701:Veratridine; C411294:pinostrobin