The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?
According to recent observations, there is worldwide vitamin D insufficiency (VDI) in various populations. A number of observations suggest a link between low serum levels of vitamin D and higher incidence of chronic pain. A few case reports have shown a beneficial effect of vitamin D therapy in patients with headache disorders. Serum vitamin D level shows a strong correlation with the latitude. Here, we review the literature to delineate a relation of prevalence rate of headaches with the latitude. We noted a significant relation between the prevalence of both tension-type headache and migraine with the latitude. There was a tendency for headache prevalence to increase with increasing latitude. The relation was more obvious for the lifetime prevalence for both migraine and tension-type headache. One year prevalence for migraine was also higher at higher latitude. There were limited studies on the seasonal variation of headache disorders. However, available data indicate increased frequency of headache attacks in autumn-winter and least attacks in summer. This profile of headache matches with the seasonal variations of serum vitamin D levels. The presence of vitamin D receptor, 1alpha-hydroxylase and vitamin D-binding protein in the hypothalamus further suggest a role of vitamin D deficiency in the generation of head pain.
Prakash
Sanjay
S
Department of Neurology, Medical College, SSG Hospital, O-19, Doctor's Quarter, Jail Road, Baroda, Gujarat 390001, India. drprakashs@yahoo.co.in
Mehta
Nivedita C
NC
Dabhi
Ajay S
AS
Lakhani
Om
O
Khilari
Madhuri
M
Shah
Nilima D
ND
D015897:Comorbidity; D005843:Geography / Q000706:statistics & numerical data / Q000639:trends*; D020773:Headache Disorders / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D015995:Prevalence; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000503:physiopathology*
Headache. 1988 Mar;28(2):111-3
3372236
Neurology. 2006 Feb 28;66(4):545-50
16354886
Cephalalgia. 1998 Oct;18(8):552-8
9827247
Headache. 2009 May;49(5):721-5
19472449
Headache. 1994 Oct;34(9):544-6
8002332
Cephalalgia. 2002 Oct;22(8):672-9
12383064
Neuroepidemiology. 2004 Nov-Dec;23(6):261-8
15297791
Cephalalgia. 2000 Dec;20(10):900-6
11304025
Cephalalgia. 1997 Nov;17(7):770-7
9399008
Neurology. 1996 Jul;47(1):52-9
8710124
Cephalalgia. 1995 Dec;15(6):482-8
8706111
Neurology. 2009 Nov 24;73(21):1796-803
19933983
Cephalalgia. 2000 Jul;20(6):566-72
11075840
Cephalalgia. 2004 Nov;24(11):960-6
15482359
Headache. 1998 May;38(5):356-65
9630788
J Headache Pain. 2009 Aug;10(4):265-70
19387792
Cephalalgia. 2003 Sep;23(7):519-27
12950377
Headache. 2000 Jun;40(6):473-9
10849044
Cephalalgia. 2010 Jan;30(1):62-7
19489885
Headache. 1996 Mar;36(3):168-73
8984090
J Chem Neuroanat. 2005 Jan;29(1):21-30
15589699
Headache. 2004 Jan;44(1):8-19
14979878
JAMA. 1998 Feb 4;279(5):381-3
9459472
J Hypertens. 2002 Jul;20(7):1303-6
12131526
Headache. 2009 Sep;49(8):1214-22
19619241
Headache. 2006 Nov-Dec;46(10):1571-4
17115990
Headache. 2004 Jun;44(6):596-602
15186304
Headache. 1994 Nov-Dec;34(10):590-2
7843955
Headache. 1995 Feb;35(2):93-7
7737869
J Occup Environ Med. 1997 Apr;39(4):320-7
9113602
J Clin Endocrinol Metab. 2002 May;87(5):2024-32
11994336
J Headache Pain. 2008 Dec;9(6):339-47
18850259
Headache. 1996 Jun;36(6):385-8
8707558
Cephalalgia. 2007 Mar;27(3):193-210
17381554
Pain. 2009 Jan;141(1-2):10-3
19084336
Headache. 2001 Sep;41(8):805-12
11576206
Proc Nutr Soc. 1994 Nov;53(3):533-43
7886053
Headache. 2009 Jan;49(1):71-8
18793211
Prog Biophys Mol Biol. 2006 Sep;92(1):65-79
16546242
Neuroepidemiology. 1995;14(2):82-91
7891818
Cephalalgia. 2008 Dec;28(12):1264-9
18727642
N Engl J Med. 2007 Jul 19;357(3):266-81
17634462
Headache. 1997 Feb;37(2):95-101
9074294
Arch Intern Med. 2009 Mar 23;169(6):626-32
19307527
Headache. 2002 Apr;42(4):275-80
12010384
Histochem Cell Biol. 2009 Mar;131(3):365-70
19034485
Cephalalgia. 2003 Feb;23(1):6-13
12534573
Neurology. 1999 Aug 11;53(3):537-42
10449117
Headache. 2002 Nov-Dec;42(10):963-73
12453027
Ann Clin Biochem. 2006 Jan;43(Pt 1):23-30
16390606
Pain Med. 2008 Nov;9(8):979-84
18346069
East Afr Med J. 1992 Apr;69(4):196-9
1644029
Headache. 2003 Jul-Aug;43(7):774-8
12890132
Headache. 2005 Jan;45(1):32-6
15663610
Int J Epidemiol. 1980 Sep;9(3):227-31
7440046
Cephalalgia. 2009 Dec;29(12):1317-25
19438921
J Clin Epidemiol. 1991;44(11):1147-57
1941010
Neurology. 2002 Mar 26;58(6):885-94
11914403
Cephalalgia. 2003 Jun;23(5):336-43
12780762
Chronobiol Int. 1990;7(5-6):467-9
2097080
Cephalalgia. 2010 May;30(5):582-92
19735479