Disseminated Mycobacterium avium complex infection in a non-HIV-infected patient undergoing continuous ambulatory peritoneal dialysis.
Isolated bone marrow infection by nontuberculous mycobacteria (NTM) is extremely rare. Recently, we encountered a case of bone marrow Mycobacterium avium complex (MAC) infection, which presented as a fever of unknown origin shortly after starting continuous ambulatory peritoneal dialysis (CAPD). The patient was diagnosed with MAC infection on the basis of PCR-restriction fragment length polymorphism analysis and sequencing of DNA obtained from bone marrow specimens. Although this was a case of severe MAC infection, there was no evidence of infection of other organs. End-stage renal disease (ESRD) patients undergoing dialysis can be considered immunodeficient; therefore, when these patients present with fever of unknown origin, opportunistic infections such as NTM infection should be considered in the differential diagnosis.
Chung
Jin Won
JW
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Cha
Young Ju
YJ
Oh
Dong Jin
DJ
Nam
Woo Jin
WJ
Kim
Su Hyun
SH
Lee
Mi Kyung
MK
Kim
Hye Ryoun
HR
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000175:diagnosis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D015269:Mycobacterium avium Complex / Q000235:genetics / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D010531:Peritoneal Dialysis, Continuous Ambulatory; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins