title: Physical activity and 5-year cognitive decline in the Doetinchem cohort study.
abstract: OBJECTIVE
  It is hypothesized that the intensity of physical activity habits, rather than the time spent on those activities, might mediate cognitive function. This study tested a possible association between changes in the time spent on or the average intensity of weekly physical activities and changes in cognitive function in healthy men and women.
  
  
  METHODS
  This longitudinal cohort study with 1,904 healthy men and women (45-75 years of age) assessed physical activity by a questionnaire and cognitive function with a neuropsychological test battery twice with an interval of 5 years.
  
  
  RESULTS
  Multiple linear regression analyses showed that changes in the time spent on physical activities were not associated with changes in cognitive function over a 5-year period. By contrast, changes in average intensity of weekly activities were significantly and positively associated with processing speed (beta = 0.063; p < 0.05).
  
  
  CONCLUSIONS
  In this longitudinal cohort study, an increase or smaller decline in average intensity was associated with a smaller age-related decline in processing speed, estimated at 6 years of aging.
authors.affiliation: Research Group Lifestyle and Health, University of Applied Sciences, Utrecht, The Netherlands. Maaike.Angevaren@hu.nl
authors.forename: Maaike
authors.initials: M
authors.lastname: Angevaren
authors.forename: Luc
authors.initials: L
authors.lastname: Vanhees
authors.forename: Astrid C J
authors.initials: AC
authors.lastname: Nooyens
authors.forename: C G Wanda
authors.initials: CG
authors.lastname: Wendel-Vos
authors.forename: W M Monique
authors.initials: WM
authors.lastname: Verschuren
mesh_terms: D000368:Aged; D000375:Aging; D015992:Body Mass Index; D003071:Cognition; D003072:Cognition Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008019:Life Style; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D009426:Netherlands / Q000453:epidemiology; D009483:Neuropsychological Tests; D011594:Psychometrics; D018570:Risk Assessment; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013997:Time Factors