Remote ischemic preconditioning will reduce graft-related events after surgical infrainguinal revascularization: evidence-based surgery hypothesis.
Surgical lower extremity revascularization obligates ischemia-reperfusion, and local ischemia-reperfusion provokes systemic inflammation; perhaps counterintuitively, remote ischemic preconditioning elicits a constructive anti-inflammatory response. So, remote ischemic preconditioning will decrease graft-related complications after surgical infrainguinal revascularization.
Walsh
Stewart R
SR
Addenbrooke's Hospital, Cambridge, UK. srwalsh@doctors.org.uk
Tang
Tjun Y
TY
Cooper
David G
DG
Sadat
Umar
U
Gaunt
Michael E
ME
D006801:Humans; D007511:Ischemia / Q000601:surgery*; D019194:Ischemic Preconditioning; D035002:Lower Extremity / Q000098:blood supply*; D011183:Postoperative Complications / Q000517:prevention & control*; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D014680:Veins / Q000637:transplantation