title: Frequency and hemostatic abnormalities in pre-DIC patients.
abstract: Disseminated intravascular coagulation (DIC) sometimes has a poor outcome, and therefore early diagnosis and treatment are required. This study prospectively evaluated the hemostatic abnormalities and the onset of DIC in 613 patients with underlying diseases to identify a useful marker for diagnosing Pre-DIC. Pre-DIC was defined as the condition of patients within a week before the onset of DIC. Initially, 34.4% of patients were diagnosed with DIC, and about 8.5% of the patients without DIC were diagnosed as DIC within a week after registration (pre-DIC). The mortality of DIC, Pre-DIC and "without DIC" was 35.3%, 32.4% and 17.2%, respectively. All hemostatic parameters were significantly worse in "DIC" than "without DIC" and the values of the prothrombin time ratio, platelet count and fibrin monomer complex could classify the three groups; "DIC", "pre-DIC" and "without DIC". No useful marker was identified that provided an adequate cutoff value to differentiate "pre-DIC" from "without DIC". A multivariate analysis identified clinical symptoms that were related to poor outcome. DIC must be treated immediately; there is no specific marker to identify pre-DIC.
authors.affiliation: First Department of Surgery, University of Occupational and Environmental Health School of Medicine, KitaKyushu, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hatada
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawasugi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mayumi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Gando
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kushimoto
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Seki
authors.forename: Seiji
authors.initials: S
authors.lastname: Madoiwa
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.forename: Shin
authors.initials: S
authors.lastname: Koga
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Iba
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D006487:Hemostasis / Q000502:physiology*; D006490:Hemostatics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010976:Platelet Count; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D006490:Hemostatics; C011468:fibrinmonomer