[Etiologic link between vascular lesions and late-onset depression: myth or reality?].
The concepts of post-stroke depression and vascular depression have emphasized the bidirectional etiologic links that may connect depression and cardiovascular risk factors. In post-stroke depression, the pathogenic role of a chronic cumulative "burden" of subcortical lesions has been well established. In what concerns late-onset depression and the symptomatic profile attributed to "vascular depressions, and despite a growing body of evidence from both neuroimaging and neuropathologic studies, this bilateral causality is still matter of debate. This field of research has highlighted the need for an interdisciplinary view in these traditionally divided fields.
Santos Brosch
Carla Micaela
CM
Mount Sinai School of Medicine, Department of Neuroscience, One Gustave L. Levy Place, Box 1065, New York, NY 10029-6574, USA. micaela.santos@mssm.edu
D001921:Brain / Q000473:pathology*; D003863:Depression / Q000209:etiology*; D006801:Humans; D020521:Stroke / Q000150:complications*