Spontaneous intracranial bleeding in a neonate with congenital afibrinogenemia.
Congenital afibrinogenemia, a very rare autosomal recessive coagulation disorder, is characterized by undetectable and extremely low antigen levels of fibrinogen in plasma. We report a male newborn with intracranial bleeding and diagnosed as congenital afibrinogenemia in the neonatal period. All members of the family were asymptomatic. Even though his sister and father showed extremely low fibrinogen levels, they did not have any symptoms. The most important finding of this case was a spontaneous intracranial hemorrhage at a very early stage of life. Another interesting point was the rapid resorption of this hemorrhage.
Ataoglu
Emel
E
Department of Pediatrics, Haseki Education and Research Hospital, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Duru
Nilgun S
NS
Celkan
Tiraje
T
Civilibal
Mahmut
M
Yavuz
Selda C
SC
Elevli
Murat
M
Ayta
Semih
S
D000347:Afibrinogenemia / Q000150:complications* / Q000151:congenital; D005190:Family; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male
D005340:Fibrinogen