Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI.
Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic ZnCl(2), Me(3)SiCH(2)MgCl, and LiCl. Tertiary alcohols were obtained in high yields with high chemoselectivities, while minimizing undesired side products produced by reduction and enolization.
Hatano
Manabu
M
Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
Ito
Orie
O
Suzuki
Shinji
S
Ishihara
Kazuaki
K