Synthesis of cyano-2,3-dihydropyrrolo[1,2-f]phenanthridine derivatives via a domino-Knoevenagel-cyclization.
In a new multicomponent reaction phenanthridine reacts with isocyanides and malonitrile in the presence of benzaldehyde derivatives to produce 2-aryl-3-(alkyl- or arylimino)-2,3-dihydropyrrolo[1,2-f]phenanthridine-1,1(12b H)-dicarbonitrile in a simple, mild, and efficient protocol in excellent yields.
Marandi
Ghasem
G
Department of Chemistry, The University of Sistan & Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
Maghsoodlou
Malek T
MT
Hazeri
Nourallah
N
Habibi-Khorassani
Sayyed M
SM
Torbati
Niloufar Akbarzadeh
NA
Rostami-Charati
Faramarz
F
Skelton
Brian W
BW
Makha
Mohamed
M
D001547:Benzaldehydes / Q000737:chemistry; D003500:Cyclization; D009570:Nitriles / Q000737:chemistry; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
D001547:Benzaldehydes; D009570:Nitriles; D010617:Phenanthridines; D011725:Pyridines; C000945:dicyanmethane; C032175:benzaldehyde
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