[Pathogenetic basis of pharmaceutical hepatitis induced by depakine in children].
42 children with epilepsy receved treatment by depakin drug. We defined the factors of lipid exchange processes of liver and their correlation between itself and with changes in immune status. The results of the studies indicated shaping the medical hepatitis with cholestatic syndrome on background of the long acceptance of depakin. Metabolic desadaptation was conditioned by glicolis activation in the condition of the oxygen deficit in tissue.
Podymova
S D
SD
Sadovnikova
I V
IV
D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001657:Biliary Dyskinesia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008111:Liver Function Tests; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid