title: Peripheral arthritis in the course of inflammatory bowel diseases.
abstract: BACKGROUND
  Musculoskeletal disorders are well-defined extra-intestinal manifestations of inflammatory bowel diseases (IBD). There is little data regarding the frequencies of IBD and extra-intestinal manifestations from Central and East Europe and Middle Eastern countries.
  
  
  OBJECTIVE
  To determine the prevalence of peripheral arthritis in IBD and to document the relationship to other extra-intestinal manifestations.
  
  
  METHODS
  Enrolled in the study were 357 patients who were diagnosed with IBD from December 2002 through January 2008. All of the patients underwent a detailed whole-body examination by a gastroenterologist and rheumatologist.
  
  
  RESULTS
  IBD-related peripheral arthritis (IBDPA) was found in 66 (18.5%) of the 357 patients (28.3% Crohn's disease, 13.5% ulcerative colitis; p=0.001 χ=11.62). IBDPA was more frequent in female patients (60.6 vs. 39.4%, p=0.000, χ=11.12). In eight (12.1%) cases, IBDPA occurred before the onset of IBD. Acute self-limiting episodes, recurrences of the attacks, and persistent symptoms of arthritis were present in 40 (60.6%), 26 (39.3%), and 29 (45.7%) patients, respectively. Arthritis was symmetrical in 33 (50%) cases. Knees (65.2%) and ankles (62.1%) were the most commonly affected joints. Erythema nodosum and pyoderma gangrenosum were more common among patients with IBDPA than patients without it (p=0.001, χ=10.49, and p=0.000 χ=25.77, respectively).
  
  
  CONCLUSIONS
  IBDPA is a frequent extra-intestinal complication of IBD. Those of female gender and the presence of Crohn's disease, erythema nodosum and pyoderma gangrenosum have a higher risk to develop IBDPA.
authors.affiliation: Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey. yukselilhami@hotmail.com
authors.forename: Ilhami
authors.initials: I
authors.lastname: Yüksel
authors.forename: Hilmi
authors.initials: H
authors.lastname: Ataseven
authors.forename: Omer
authors.initials: O
authors.lastname: Başar
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Köklü
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ertuğrul
authors.forename: Aysel
authors.initials: A
authors.lastname: Ulker
authors.forename: Ulkü
authors.initials: U
authors.lastname: Dağlı
authors.forename: Nurgül
authors.initials: N
authors.lastname: Saşmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000843:Ankle Joint; D001168:Arthritis / Q000453:epidemiology*; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications* / Q000453:epidemiology; D003424:Crohn Disease / Q000150:complications* / Q000453:epidemiology; D004893:Erythema Nodosum / Q000150:complications / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D008877:Middle East / Q000453:epidemiology; D015995:Prevalence; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
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