Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction.
Cocaine addiction has somatic, psychological, psychiatric, socio-economic and legal implications in the developed world. Presently, there is no medication approved for the treatment of cocaine addiction. In recent years, data from the literature (pre-clinical studies and clinical trials) have provided several lines of evidence that serotonin (5-HT) and 5-HT receptors play a modulatory role in the mechanisms of action of cocaine. Here we review the contribution of 5-HT receptor subtypes to cocaine sensitization, discrimination, conditioned place preference, self-administration, reinstatement of seeking behavior and withdrawal symptoms in laboratory animals. Additionally, the consequences of chronic cocaine exposure on particular 5-HT receptor-assigned functions in pre-clinical studies are presented.
Filip
Małgorzata
M
Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, 31-343 Kraków, 12 Smetna, Poland. filip@if-pan.krakow.pl
Alenina
Natalia
N
Bader
Michael
M
Przegaliński
Edmund
E
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D003042:Cocaine / Q000008:administration & dosage / Q000633:toxicity; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003259:Consummatory Behavior / Q000187:drug effects / Q000502:physiology; D004192:Discrimination, Psychological / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D005059:Euphoria / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009042:Motivation; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology*; D012646:Self Administration; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011985:Receptors, Serotonin; D003042:Cocaine; D004298:Dopamine