MASPECTRAS 2: An integration and analysis platform for proteomic data.
MASPECTRAS 2 is a freely available platform for integrating MS protein identifications with information from the major bioinformatics databases (ontologies, domains, literature, etc.). It assists researchers in understanding their data and publishing through sample comparisons, targeted queries, summaries, and exports in multiple formats such as PRIDE XML (Jones et al., Nucleic Acids Res. 2008, 36, D878-D883). MASPECTRAS 2 also comprises mechanisms to facilitate its integration in a high-throughput infrastructure. We illustrate application of MASPECTRAS 2 with unpublished tyrosine kinase inhibitor drug proteomics profiles in cancerous cells.
Ubaida Mohien
Ceereena
C
Institute for Genomics and Bioinformatics, Graz University of Technology, Austria.
Hartler
Jürgen
J
Breitwieser
Florian
F
Rix
Uwe
U
Remsing Rix
Lily
L
Winter
Georg E
GE
Thallinger
Gerhard G
GG
Bennett
Keiryn L
KL
Superti-Furga
Giulio
G
Trajanoski
Zlatko
Z
Colinge
Jacques
J
D000814:Aniline Compounds / Q000494:pharmacology; D045744:Cell Line, Tumor; D000069439:Dasatinib; D030562:Databases, Protein; D006801:Humans; D013058:Mass Spectrometry; D009363:Neoplasm Proteins / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D040901:Proteomics / Q000379:methods*; D011743:Pyrimidines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012984:Software; D013844:Thiazoles / Q000494:pharmacology; D014584:User-Computer Interface
D000814:Aniline Compounds; D009363:Neoplasm Proteins; D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011804:Quinolines; D013844:Thiazoles; C471992:bosutinib; D000069439:Dasatinib