High-performance liquid chromatography of biologically important, small epimeric peptides and their L, D-amino acid content.
Since most of the proteinogenic alpha-amino acids contain a chiral carbon atom, the stereoisomers of both these amino acids and the peptides in which they are to be found may possess differences in biological activity in living systems. The important analytical task of the separation of optical isomers is achieved mainly by chromatographic methods. This special review surveys direct and indirect HPLC separations of biologically important, small epimeric peptides and their L, D-amino acid content.
Ilisz
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Department of Inorganic and Analytical Chemistry, University of Szeged, H-6720 Szeged, Dóm tér 7, Hungary.
Pataj
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Aranyi
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Péter
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D000595:Amino Acid Sequence; D000596:Amino Acids; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism; D013237:Stereoisomerism
D000596:Amino Acids; D001688:Biological Products; D010455:Peptides