Schizophrenia and language--shall we look for a deficit of deviance detection?
In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. We suggest that a deficit in the hemispheric specialization for language may be a consequence of the other recently shown neurophysiological deficit of schizophrenia, namely deviance detection. We hypothesise that a deficit of deviance detection related to the dysfunction of NMDA receptors in schizophrenia leads to the abnormal interaction between the parallel and sequential streams of speech processing in the brain. This hypothesis opens perspectives for genetic, molecular and pharmacological studies of the deficit of deviance detection in schizophrenia, as reflected by event-related potentials and neuroimaging during speech processing.
Strelnikov
Kuzma
K
CerCo, Université Toulouse 3, CNRS, Faculté de Médecine de Rangueil, 31062 Toulouse CEDEX9, France. kuzma@cerco.ups-tlse.fr
D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D007802:Language; D007806:Language Disorders / Q000209:etiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology; D013060:Speech / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate