[Clinical research on improvement of glucose metabolic marker level by coffee drinking-validity of saliva caffeine concentration measurement].
We measured both serum and saliva caffeine concentration using HPLC and assessed the correlation between them in volunteers with mild obesity. Significant correlation was shown between saliva and serum caffeine concentration. It may be necessary to measure caffeine metabolite concentration because its metabolites may also have an improving effect of glucose metabolism. In summary, we found that saliva caffeine concentration measurement was useful to assess caffeine intake level. Moreover, it will be helpful to know whether caffeine has an improving effect of glucose metabolism.
Okada
Tomoko
T
Department of Clinical Pharmacy and Pharmaceutical Care, Kyushu University, Fukuoka, Japan.
Kobayashi
Daisuke
D
Kono
Suminori
S
Shimazoe
Takao
T
D002110:Caffeine / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003069:Coffee; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000517:prevention & control; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D012463:Saliva / Q000737:chemistry*
D003069:Coffee; D007328:Insulin; D002110:Caffeine; D005947:Glucose