title: Development of aggressive squamous cell carcinoma in epidermodysplasia verruciformis associated with human papillomavirus type 22b.
abstract: Epidermodysplasia verruciformis (EV) is a rare genetic disease characterized by abnormal susceptibility to infection with EV-related human papillomavirus (HPV), now known as the beta-papillomavirus (beta-PV). Clinically specific beta-PV-type-associated EV, especially HPV-5 and -8, shows a high rate of progression to squamous cell carcinoma (SCC). In this report, we describe a 39-year-old Korean man with HPV-22b-associated EV who developed a rapidly progressing SCC. The patient presented with a huge destructive mass on the nose. Histopathological evaluation of the mass was compatible with well-differentiated SCC. HPV typing results from both EV and SCC specimens demonstrated HPV-22b which has not been considered to be associated with SCC in EV patients so far. The patient underwent surgical excision and postoperative radiotherapy for locoregional control. This is the first report presenting the association of an SCC arising from previous EV with HPV-22b infection only.
authors.affiliation: Department of Dermatology and Cutaneous Biology Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sinchon-Dong, Seodaemoon-Gu, Seoul, Korea.
authors.forename: Taegyun
authors.initials: T
authors.lastname: Kim
authors.forename: Jae Chan
authors.initials: JC
authors.lastname: Park
authors.forename: Mi Ryung
authors.initials: MR
authors.lastname: Roh
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Park
authors.forename: Se Heon
authors.initials: SH
authors.lastname: Kim
authors.forename: Nam Hoon
authors.initials: NH
authors.lastname: Cho
authors.forename: Min-Geol
authors.initials: MG
authors.lastname: Lee
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy / Q000821:virology*; D004819:Epidermodysplasia Verruciformis / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy / Q000821:virology*