title: [Comparison between saline solution and heparin in arterial catheter patency in intensive care units: a systematic review].
abstract: OBJECTIVE
  To find the best scientific evidence on the effectiveness of the saline solution compared with heparin in maintaining patency of the arterial cannula in intensive care units.
  
  
  METHODS
  A review of the evidence was made using the databases: MEDLINE, CINAHL, CUIDEN and Cochrane Library. The criteria that limited the search were: the type of study (randomised control trials (RCTs), systematic reviews and/or meta-analysis), the year of publication of studies (1990-2009) and language, English and / or Spanish. Finally, a critical appraisal of selected papers was carried out.
  
  
  RESULTS
  Two meta-analysis and six RCTs were identified and analysed. Results from one of the meta-analysis and two RCTs supported the use of heparin for maintaining peripheral arterial catheter patency. In the rest, however, no significant differences were found regarding the arterial catheter patency between the control (saline) and intervention (heparin).
  
  
  CONCLUSIONS
  Recent studies suggest that it is not necessary to use heparin to maintain a patent arterial catheter. From this review the performing of a nationwide multicentre study is proposed to implement the use of saline in Spain.
authors.affiliation: UCI, Clínica Universidad de Navarra, Universidad de Navarra, Escuela Universitaria de Enfermería, Universidad de Navarra, Pamplona, Navarra, España. mvazca@unav.es
authors.forename: Mónica
authors.initials: M
authors.lastname: Vázquez-Calatayud
authors.forename: Mari Carmen
authors.initials: MC
authors.lastname: Portillo
mesh_terms: D057785:Catheters; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007362:Intensive Care Units; D012965:Sodium Chloride / Q000627:therapeutic use*; D014654:Vascular Patency
chemical_list: D005343:Fibrinolytic Agents; D012965:Sodium Chloride; D006493:Heparin