Copper-catalyzed tandem process: an efficient approach to 2-substituted-1,4-benzodioxanes.
An efficient method for the preparation of various 2-substituted-1,4-benzodioxanes by CuBr-catalyzed tandem reactions of 2-((o-iodophenoxy)methyl)oxiranes with phenols has been developed. The reaction involves the ring-opening process of 2-((2-iodophenoxy)methyl)oxirane followed by an intramolecular C-O cross coupling cyclization.
Liu
Yunyun
Y
Department of Chemistry, Xi Xi Campus, Zhejiang University, Hangzhou, Zhejiang 310028, PR China.
Bao
Weiliang
W
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004146:Dioxanes / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry
D004146:Dioxanes; D010636:Phenols; D003300:Copper; C527681:1,4-benzodioxan