title: In vivo micron-scale arthroscopic imaging of human knee osteoarthritis with optical coherence tomography: comparison with magnetic resonance imaging and arthroscopy.
abstract: Current treatments for osteoarthritis are pain relief and total joint arthroplasty. There is a clinical need for early osteoarthritis diagnostic methods for potential preventive interventions. The resolution achieved with radiography, magnetic resonance imaging (MRI), and arthroscopy is too limited for the assessment of early disease. The high resolution, small fiber-optic probes, and real-time imaging of optical coherence tomography (OCT) makes this method ideal for assessing articular cartilage. In this article, we describe in vivo human arthroscopic OCT with qualitative baseline comparisons made with MRI and arthroscopy. Two-year MRI follow-ups are under way to quantitatively compare OCT with MRI and to assess the long-term outcomes of changes noted in the OCT images.
authors.affiliation: Center for Optical Coherence Tomography and Optical Physics, Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Zheng
authors.forename: Scott D
authors.initials: SD
authors.lastname: Martin
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Rashidifard
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Mark E
authors.initials: ME
authors.lastname: Brezinski
mesh_terms: D000328:Adult; D001182:Arthroscopy / Q000379:methods*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000473:pathology; D018579:Patient Selection; D011859:Radiography; D041623:Tomography, Optical Coherence / Q000379:methods*
references.citation: Arthritis Rheum. 2007 May;56(5):1378-83
references.pmid: 17469094
references.citation: Appl Opt. 2006 Jun 20;45(18):4464-79
references.pmid: 16778957
references.citation: Anal Bioanal Chem. 2003 Nov;377(6):1003-6
references.pmid: 14564447
references.citation: IEEE Trans Med Imaging. 2005 Feb;24(2):155-9
references.pmid: 15707241
references.citation: J Rheumatol. 1999 Mar;26(3):627-35
references.pmid: 10090174
references.citation: Arthritis Res Ther. 2005;7(2):R318-23
references.pmid: 15743479
references.citation: Science. 1997 Jun 27;276(5321):2037-9
references.pmid: 9197265
references.citation: Rheum Dis Clin North Am. 2008 Aug;34(3):515-29
references.pmid: 18687270
references.citation: Br Med Bull. 2007;84:5-23
references.pmid: 17785279
references.citation: Radiol Clin North Am. 2002 Sep;40(5):1081-94
references.pmid: 12462469
references.citation: J Rheumatol. 2001 Jun;28(6):1311-8
references.pmid: 11409125