Autoregulation of cardiac l-type calcium channels.
l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.
Satin
Jonathan
J
Department of Physiology, MS508 University of Kentucky College of Medicine, Lexington, KY 40536-0298, USA. jsatin1@uky.edu
Schroder
Elizabeth A
EA
D000818:Animals; D020746:Calcium Channels, L-Type / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling; D006706:Homeostasis; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D021381:Protein Transport; D014158:Transcription, Genetic
D020746:Calcium Channels, L-Type; C419385:L-type calcium channel alpha(1C)
J Mol Cell Cardiol. 1998 Oct;30(10):1899-916
9799645
Circ Res. 2004 Sep 17;95(6):604-11
15308581
Physiol Rev. 2009 Apr;89(2):411-52
19342611
J Mol Cell Cardiol. 1997 Jul;29(7):1791-803
9236134
Am J Physiol. 1994 Sep;267(3 Pt 2):H1222-6
8092289
Circ Res. 2009 Jun 19;104(12):1373-81
19461046
J Clin Invest. 2006 Mar;116(3):623-6
16511595
Cell. 2006 Nov 3;127(3):591-606
17081980
Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1906-16
17158651
J Mol Cell Cardiol. 2000 Oct;32(10):1841-9
11013128
Circ Res. 2007 May 25;100(10):1476-85
17463319
Circ Res. 2000 Dec 8;87(12):1087-94
11110764
Cell Calcium. 2006 Feb;39(2):175-86
16303176
J Appl Physiol (1985). 2000 May;88(5):1898-906
10797155
J Biol Chem. 2003 Feb 14;278(7):5021-8
12473653
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17705-10
16314582
Biochemistry. 1996 Aug 13;35(32):10392-402
8756695
Cell Calcium. 2008 Oct;44(4):353-62
19230140
Biochem Biophys Res Commun. 2002 Aug 16;296(2):429-33
12163037
Neuron. 2003 Sep 11;39(6):951-60
12971895
Annu Rev Physiol. 2008;70:23-49
17988210
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13093-8
14569017
J Mol Cell Cardiol. 2006 May;40(5):619-28
16600289
J Neurochem. 1994 Oct;63(4):1558-64
7931310
Cell Calcium. 2005 Apr;37(4):301-9
15755491
J Cardiovasc Electrophysiol. 2000 Nov;11(11):1262-9
11083247
J Clin Invest. 1996 Feb 1;97(3):656-63
8609220
Am J Physiol. 1988 Dec;255(6 Pt 2):H1434-42
2849320
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1299-308
16501029
Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1153-62
10749709
Circulation. 2003 Jun 10;107(22):2844-9
12756152
Circulation. 1997 Apr 1;95(7):1945-53
9107184
Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16574-9
17053072
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1959-71
16648185
FEBS Lett. 2003 Jul 10;546(2-3):349-54
12832067
Circ Res. 2002 Sep 20;91(6):517-24
12242270
Endocrine. 2002 Dec;19(3):339-44
12624436
Circ Res. 2006 Apr 14;98(7):868-78
16614312
J Physiol. 2006 Oct 1;576(Pt 1):87-102
16809371
Circ Res. 2005 Dec 9;97(12):1288-95
16293789