Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G (1), along with the previously isolated compound, psammaplysin F (2). When tested against two different strains of the parasite Plasmodium falciparum (Dd2 and 3D7), 2 displayed IC(50) values of 1.4 and 0.87 microM, respectively, while 1 showed 98% inhibition at 40 microM against the chloroquine-resistant (Dd2) strain of P. falciparum.
Yang
Xinzhou
X
Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
Davis
Rohan A
RA
Buchanan
Malcolm S
MS
Duffy
Sandra
S
Avery
Vicky M
VM
Camp
David
D
Quinn
Ronald J
RJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001315:Australia; D002738:Chloroquine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000962:Antimalarials; D006842:Hydrocarbons, Brominated; C475724:bromotyrosine; C550029:psammaplysin G; D014443:Tyrosine; D002738:Chloroquine