Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis.
BACKGROUND
Cystic fibrosis (CF) affects the lungs causing infections and inflammation. Surfactant protein D (SP-D) is an innate defense lectin primarily secreted in the lungs. We investigated the influence of the SP-D Met11Thr polymorphism on CF lung function; and serum SP-D as a marker for CF lung disease.


METHODS
For 107 CF patients (73 children, and 34 adults) serum SP-D and SP-D Met11Thr genotype were available. Leukocyte count was obtained for a subset of patients. Lung function was measured as forced expiratory volume in one second (FEV-1).


RESULTS
Serum SP-D was increased in CF patients compared to healthy controls, positively correlated to leukocyte count, and negatively correlated to FEV-1. We found no correlation between SP-D Met11Thr genotype and FEV-1, and we found corresponding genotype frequencies in CF patients and in healthy controls.


CONCLUSIONS
Serum SP-D in CF patients was increased in parallel with leukocyte count and with reduced FEV-1 and may constitute an alternative biomarker for lung disease, in the clinical setting and in research.
Olesen
Hanne Vebert
HV
Department of Pediatrics, Aarhus University Hospital, Skejby, 8200 Arhus N, Denmark. hvo@dadlnet.dk
Holmskov
Uffe
U
Schiøtz
Peter Oluf
PO
Sørensen
Grith Lykke
GL
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood* / Q000235:genetics; D055815:Young Adult
D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D