Directing dendritic cell immunotherapy towards successful cancer  treatment.
The use of dendritic cells (DCs) for tumor immunotherapy represents a powerful approach for harnessing the patient's own immune system to eliminate tumor cells. However, suboptimal conditions for generating potent immunostimulatory DCs, as well as the induction of tolerance and suppression mediated by the tumors and its microenvironment have contributed to limited success. Combining DC vaccines with new approaches that enhance immunogenicity and overcome the regulatory mechanisms underlying peripheral tolerance may be the key to achieving effective and durable anti-tumor immune responses that translate to better clinical outcomes.
Sabado
Rachel Lubong
RL
New York University School of Medicine, NYU Langone Medical Center Cancer Institute, 550 First Avenue SML 1303, New York, NY 10016, USA. rachel.sabado@nyumc.org
Bhardwaj
Nina
N
D000938:Antigen-Presenting Cells / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
D019496:Cancer Vaccines
Vaccine. 2009 Oct 9;27(43):6088-94
19450647
Clin Immunol. 2007 Nov;125(2):184-93
17827069
Ann Surg. 2002 Apr;235(4):540-9
11923611
J Immunother. 2006 Sep-Oct;29(5):545-57
16971810
Adv Immunol. 2006;90:1-50
16730260
Biochem Soc Trans. 2008 Dec;36(Pt 6):1478-81
19021579
Front Biosci (Landmark Ed). 2009 Jan 01;14:796-807
19273100
Eur J Dermatol. 2006 Jul-Aug;16(4):454-5
16935819
J Immunother. 2009 Jan;32(1):1-11
19307988
Blood. 2006 Aug 1;108(3):947-55
16614246
Blood. 2004 Mar 1;103(5):1763-9
14615377
Blood. 2005 Jan 1;105(1):266-73
15331446
Mol Ther. 2000 Feb;1(2):171-9
10933928
Nat Rev Immunol. 2003 Feb;3(2):133-46
12563297
Cancer. 2009 Aug 15;115(16):3670-9
19536890
J Clin Oncol. 2006 Jul 1;24(19):3089-94
16809734
Gene Ther. 2007 Jun;14(11):847-62
17361214
Blood. 2005 Mar 15;105(6):2465-72
15546948
Immunol Rev. 2008 Aug;224:141-65
18759925
J Exp Med. 2002 Aug 19;196(4):541-9
12186845
Blood. 2001 Jan 1;97(1):114-21
11133750
Curr Top Microbiol Immunol. 2005;289:259-92
15791960
J Leukoc Biol. 2007 Dec;82(6):1365-74
17711977
J Leukoc Biol. 2007 Nov;82(5):1106-14
17698915
J Clin Invest. 2007 May;117(5):1155-66
17476345
J Exp Med. 2005 May 2;201(9):1503-17
15867097
Trends Immunol. 2001 Feb;22(2):102-7
11286712
J Immunother. 2008 Apr;31(3):294-309
18317358
J Virol. 2005 Jan;79(1):17-27
15596797
Nat Rev Immunol. 2007 Oct;7(10):790-802
17853902
Med Oncol. 2006;23(2):273-82
16720928
Annu Rev Immunol. 2002;20:621-67
11861614
Clin Cancer Res. 2005 Mar 1;11(5):1910-7
15756017
Eur J Immunol. 2009 Sep;39(9):2424-36
19662633
Cell Microbiol. 2005 Apr;7(4):481-8
15760448
Nat Biotechnol. 2008 Mar;26(3):326-34
18297056
Vaccine. 2002 Dec 19;20 Suppl 4:A8-A22
12477423
Curr Opin Immunol. 2002 Apr;14(2):172-7
11869888
J Exp Med. 2005 Oct 3;202(7):885-91
16186187
J Immunol. 2000 Jul 1;165(1):566-72
10861097
J Immunother. 2005 Sep-Oct;28(5):505-16
16113607
Cancer Res. 2007 Feb 15;67(4):1842-52
17293384
Immunol Cell Biol. 2008 Oct;86(7):580-7
18679407
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12293-7
12218188
Nat Immunol. 2005 Jul;6(7):722-9
15951814
Blood. 2002 Jul 1;100(1):174-7
12070024
J Exp Med. 2001 Jan 15;193(2):233-8
11208863
Immunol Lett. 2008 Apr 15;117(1):1-8
18243339
Cancer Immunol Immunother. 2008 Nov;57(11):1589-97
18322684
J Immunother. 2002 May-Jun;25(3):278-88
12000870
J Clin Invest. 2006 Jan;116(1):90-100
16357940
Clin Cancer Res. 2009 Apr 1;15(7):2531-40
19318472
Nat Biotechnol. 2004 Dec;22(12):1521-2
15583655
Blood. 2006 Mar 1;107(5):2037-44
16293609
Blood. 2003 Jan 15;101(2):729-38
12393603
J Virol. 2007 May;81(10):5385-94
17314166
J Immunol. 2004 Feb 15;172(4):2232-7
14764691
J Clin Invest. 2005 Mar;115(3):739-46
15696196
Int J Cancer. 2006 Jul 15;119(2):317-27
16482562
Clin Cancer Res. 2003 Nov 1;9(14):5091-100
14613986
Nat Immunol. 2005 Aug;6(8):769-76
15995707
Clin Cancer Res. 2007 Jul 1;13(13):3883-91
17606721
Cancer Res. 2001 Jun 15;61(12):4766-72
11406550
Gene Ther. 2006 Apr;13(7):630-40
16355115
Blood. 2009 Mar 12;113(11):2451-60
19029446
Cancer Res. 2003 Jan 1;63(1):12-7
12517769
J Immunol. 2008 Mar 1;180(5):3585-93
18292586
Cancer Res. 2001 Sep 1;61(17):6451-8
11522640
Handb Exp Pharmacol. 2009;(188):31-49
19031020
J Clin Invest. 2007 Sep;117(9):2570-82
17710230
Nat Immunol. 2008 Mar;9(3):239-44
18285775
Cancer Sci. 2009 Aug;100(8):1389-96
19459853
Methods Mol Med. 2005;109:97-112
15585916
Trends Mol Med. 2004 Jan;10(1):15-8
14720581
Clin Cancer Res. 2009 Feb 1;15(3):1086-95
19188184
J Leukoc Biol. 2008 Jul;84(1):319-25
18426971
Biol Proced Online. 2003;5:197-203
14615816
J Exp Med. 2007 Feb 19;204(2):421-30
17296787
J Clin Oncol. 2009 Feb 20;27(6):945-52
19139436
Blood. 2003 Feb 1;101(3):977-82
12393470
Nat Med. 2004 Dec;10(12):1359-65
15568033
Clin Cancer Res. 2008 May 1;14(9):2740-8
18451240
Cancer. 2007 Dec 15;110(12):2614-27
18000991
Expert Rev Vaccines. 2008 Sep;7(7):1069-84
18767955
J Clin Invest. 2008 Dec;118(12):3990-4001
19033668
Cancer Immunol Immunother. 2007 Oct;56(10):1597-604
17440723
Nat Immunol. 2007 Nov;8(11):1217-26
17922015
J Exp Med. 2004 Mar 15;199(6):815-24
15024047
J Exp Med. 2000 Nov 6;192(9):1213-22
11067871
Trends Immunol. 2009 Jan;30(1):23-32
19059004
Nat Immunol. 2008 Jun;9(6):641-9
18454151
Cancer Gene Ther. 2003 Mar;10(3):209-14
12637942
J Immunol Methods. 2003 Jun 1;277(1-2):1-16
12799035
Immunology. 2007 May;121(1):1-14
17386080
Blood. 2006 Jul 15;108(2):544-50
16537810
Nat Rev Cancer. 2008 May;8(5):351-60
18418403
Curr Protoc Immunol. 2005 Jul;Chapter 22:Unit 22F.4
18432951
J Immunother. 2006 May-Jun;29(3):313-9
16699374
Adv Exp Med Biol. 2007;601:123-31
17712999
Cancer Res. 2006 Jul 15;66(14):7276-84
16849577
J Biol Chem. 2006 Jul 7;281(27):18763-73
16648140
Exp Mol Med. 2009 Feb 28;41(2):61-6
19287186
Nat Med. 2005 Feb;11(2):130-7
15665830
Pharmacol Res. 2004 May;49(5):383-96
14998548
Immunol Rev. 2009 May;229(1):192-215
19426223
Trends Immunol. 2003 Mar;24(3):108-11
12615202
J Immunother. 2005 Sep-Oct;28(5):480-7
16113604
J Clin Oncol. 2005 Dec 10;23(35):8978-91
16260696
J Clin Oncol. 2007 Jun 20;25(18):2546-53
17577033
Nat Immunol. 2002 Sep;3(9):867-74
12154358
Immunol Rev. 2008 Apr;222:287-98
18364009
Int J Cancer. 2003 Apr 20;104(4):437-45
12584740
Nat Med. 2006 Mar;12(3):335-41
16474399
Cancer Res. 2003 Oct 1;63(19):6478-87
14559840
J Immunol. 2000 Nov 15;165(10):5713-9
11067929
J Clin Invest. 2004 Jul;114(2):280-90
15254595
J Exp Med. 2005 Nov 7;202(9):1213-23
16275760
Blood. 2002 Aug 15;100(4):1354-61
12149218
Cancer Immunol Immunother. 2006 Jul;55(7):819-29
16187085
Gene Ther. 2000 Dec;7(23):2028-35
11175315
Immunol Rev. 1999 Aug;170:85-100
10566144
Cancer Res. 2009 Jun 15;69(12):5142-50
19491278
Cancer Res. 2006 Feb 15;66(4):1912-6
16488988
Immunol Rev. 2004 Jun;199:251-63
15233739
Cancer Res. 2007 Nov 1;67(21):10528-37
17974997
Cell Immunol. 2006 Feb;239(2):87-91
16781694
Nat Immunol. 2001 Oct;2(10):947-50
11547333
Cancer Res. 2006 May 1;66(9):4904-12
16651447
J Immunol. 2008 Oct 15;181(8):5396-404
18832696
Cancer Immunol Immunother. 2009 Sep;58(9):1363-73
19172271
Nat Immunol. 2000 Nov;1(5):426-32
11062503
J Clin Oncol. 2005 Feb 1;23(4):720-31
15613691
Clin Cancer Res. 2008 May 15;14(10):3044-51
18483370
J Clin Invest. 2002 Feb;109(3):409-17
11828001
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1969-74
14762166
Cancer. 2008 Sep 1;113(5):975-84
18646045
Cancer Immunol Immunother. 2005 Apr;54(4):307-14
15599732
Cancer Lett. 2008 Dec 18;272(2):186-96
18585853
Ann Oncol. 2006 Apr;17(4):563-70
16418308
Cancer Res. 2002 Jun 15;62(12):3459-65
12067989
Blood. 2008 Oct 15;112(8):3264-73
18669894
Lancet. 2004 Feb 21;363(9409):594-9
14987883
Cancer Immunol Immunother. 2006 Oct;55(10):1209-18
16331519
Vaccine. 2008 Mar 4;26(10):1375-86
18272264
Cancer Res. 2003 Oct 1;63(19):6501-5
14559843
Cancer Immunol Immunother. 2004 May;53(5):453-60
14760510
Cytotherapy. 2005;7(2):195-202
16040399
J Immunol. 2003 Apr 15;170(8):4069-76
12682236
Nat Immunol. 2002 Feb;3(2):135-42
11812990
Nat Biotechnol. 2004 Dec;22(12):1546-53
15558048
J Immunol. 2006 Aug 15;177(4):2276-84
16887988
Hum Gene Ther. 2004 Apr;15(4):393-404
15053864
Trends Mol Med. 2004 Jun;10(6):251-7
15177188
J Clin Oncol. 2000 Dec 1;18(23):3964-73
11099326
Immunol Rev. 2009 May;229(1):152-72
19426221
Nat Rev Immunol. 2004 Jul;4(7):499-511
15229469
Immunity. 2008 Feb;28(2):258-70
18275834
Nat Rev Immunol. 2004 Oct;4(10):762-74
15459668
J Immunol. 2005 Jul 1;175(1):112-23
15972637
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20410-5
19074257
Nat Immunol. 2009 Jul;10(7):713-20
19465907
J Exp Med. 2009 Aug 3;206(8):1717-25
19581407
J Exp Med. 2009 Jul 6;206(7):1589-602
19564349
Annu Rev Immunol. 2000;18:767-811
10837075
Hum Immunol. 2009 May;70(5):281-8
19236899
Nature. 2006 May 4;441(7089):101-5
16625202
Cancer Res. 2004 Sep 1;64(17):5934-7
15342370
J Immunol. 2004 Mar 1;172(5):2845-52
14978085
BMC Cancer. 2007 Jul 03;7:119
17608923
J Immunol. 2005 Mar 15;174(6):3808-17
15749922
J Immunol. 2008 Jul 1;181(1):776-84
18566444
Blood. 2005 Aug 15;106(4):1278-85
15878980
Expert Rev Vaccines. 2007 Dec;6(6):913-24
18377355
J Immunol. 2002 Sep 1;169(5):2756-61
12193750
Microbes Infect. 2009 Apr;11(5):620-4
19371794
J Immunother. 2008 Oct;31(8):781-91
18779741
Cancer Res. 2001 Apr 15;61(8):3388-93
11309297
J Immunother. 2008 Jul-Aug;31(6):591-8
18528294
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5
19139407
Immunobiology. 2006;211(6-8):599-608
16920498
Cancer Res. 2001 Sep 1;61(17):6445-50
11522639
Eur J Immunol. 2003 Apr;33(4):1052-62
12672071
Cancer Res. 2008 Nov 15;68(22):9441-50
19010919
Curr Dir Autoimmun. 2005;8:124-39
15564719
Curr Opin Immunol. 2005 Apr;17(2):170-4
15766677
J Exp Med. 2006 Mar 20;203(3):599-606
16505139
Ann Surg Oncol. 2006 Sep;13(9):1252-8
16952047
Cancer Sci. 2006 Sep;97(9):807-12
16805854
Semin Oncol. 2006 Feb;33(1 Suppl 3):S11-6
16516670
J Virol. 2009 Jul;83(13):6779-89
19386711
Semin Cell Dev Biol. 2008 Aug;19(4):414-22
18708154
Blood. 2005 Feb 1;105(3):1162-9
15479730
Curr Opin Immunol. 2009 Feb;21(1):10-6
19223160