title: Circadian modulation of neuroplasticity in humans and potential therapeutic implications.
abstract: Learning, memory, and recovery from various neurological insults occur by a process known as neuroplasticity. Neuroplastic changes occur by a variety of physiological processes that modify central nervous system structure and function. The ability to non-invasively induce neuroplastic change in humans is developing as an exciting new field in neuroscience and may ultimately improve treatment outcomes for those suffering various neurological conditions reliant on neuroplasticity for recovery of function. The induction of neuroplastic changes is influenced by several factors, and do not occur evenly throughout the day, but appear to be under circadian control. This review will discuss the known mechanisms and techniques used to induce neuroplasticity, circadian modulation of neuroplasticity, and will discuss the potential implications of these findings for human neurorehabilitation.
authors.affiliation: Discipline of Physiology, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, 5005, South Australia.
authors.forename: M V
authors.initials: MV
authors.lastname: Sale
authors.forename: M C
authors.initials: MC
authors.lastname: Ridding
authors.forename: M A
authors.initials: MA
authors.lastname: Nordstrom
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000494:pharmacology
chemical_list: D018377:Neurotransmitter Agents