[Cutaneous adverse reaction to carbamazepine: unusual presentation].
Besides its use for the control of seizures, carbamazepine is being increasingly prescribed for neuropathic pain and depression, and this may explain the increased incidence of cutaneous drug reactions, namely Setevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis associated with this drug. We report a case of a 42-year-old woman, medicated with levotyroxin for years and carbamazepine for fifteen days due to a depressive state. A mucous and cutaneous eruption suddenly appeared and the diagnosis of SSJ was made. Skin biopsy confirmed the clinical diagnosis and patch testing and intradermal test were negative. The remaining laboratory findings were normal. Supportive measures and a course of oral predisolone (started at 1.5 mg/Kg) with progressive tapering were introduced and carbamazepine was immediately stopped, with a complete clinical resolution within two weeks.
Duarte
Ana Filipa
AF
Serviço de Dermatologia e Venereologia, Hospital de São João/Faculdade de Medicina do Porto, Porto.
Baudrier
Teresa
T
Mota
Alberto
A
Azevedo
Filomena
F
D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005533:Foot Dermatoses / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans
D018692:Antimanic Agents; D002220:Carbamazepine