title: Wiring the brain: the biology of neuronal guidance.
abstract: The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic and postnatal development through a series of precisely orchestrated developmental events regulated by specific molecular mechanisms. Below we review the most important features of mammalian brain wiring derived from work in both mammals and in nonmammalian species. These mechanisms are highly conserved throughout evolution, simply becoming more complex in the mammalian brain. This fascinating area of biology is uncovering the essence of what makes the mammalian brain able to perform the everyday tasks we take for granted, as well as those which give us the ability for extraordinary achievement.
authors.affiliation: INSERM, UMRS_968, Institut de la Vision, Department of Development, 17 rue Moreau, Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Chédotal
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Richards
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D001921:Brain / Q000166:cytology* / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology*
references.citation: Development. 2003 Jul;130(13):2929-37
references.pmid: 12756176
references.citation: Science. 1992 Mar 13;255(5050):1441-3
references.pmid: 1542795
references.citation: J Neurosci. 2008 Apr 23;28(17):4414-22
references.pmid: 18434520
references.citation: J Neurosci. 2009 Jul 15;29(28):8914-26
references.pmid: 19605629
references.citation: Annu Rev Neurosci. 2008;31:295-315
references.pmid: 18558857
references.citation: Neuron. 1996 Jan;16(1):55-62
references.pmid: 8562091
references.citation: J Neurosci. 2000 Jun 1;20(11):4112-9
references.pmid: 10818146
references.citation: Cell. 2004 Oct 15;119(2):257-72
references.pmid: 15479642
references.citation: Dev Growth Differ. 2009 Apr;51(3):325-42
references.pmid: 19298550
references.citation: Mol Cell Neurosci. 2005 Mar;28(3):547-55
references.pmid: 15737744
references.citation: Nat Rev Neurosci. 2006 Apr;7(4):259-67
references.pmid: 16543914
references.citation: Neuron. 1994 Nov;13(5):1039-53
references.pmid: 7946344
references.citation: Nature. 2007 Nov 1;450(7166):56-62
references.pmid: 17972876
references.citation: Nature. 1990 Sep 13;347(6289):179-81
references.pmid: 2395469
references.citation: Development. 2004 Feb;131(3):681-92
references.pmid: 14729576
references.citation: Development. 1992 Apr;114(4):825-31
references.pmid: 1618146
references.citation: PLoS Biol. 2008 Apr 29;6(4):e103
references.pmid: 18447583
references.citation: PLoS Biol. 2008 May 13;6(5):e116
references.pmid: 18479186
references.citation: Cell Tissue Res. 1997 Nov;290(2):189-96
references.pmid: 9321679
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10296-301
references.pmid: 19541606
references.citation: Cereb Cortex. 2009 Aug;19(8):1705-7
references.pmid: 19293397
references.citation: J Neurosci. 1997 Apr 1;17(7):2445-58
references.pmid: 9065505
references.citation: J Comp Neurol. 2004 Nov 29;480(1):38-56
references.pmid: 15515022
references.citation: J Neurosci. 2007 Mar 14;27(11):3037-45
references.pmid: 17360927
references.citation: Science. 2005 Nov 4;310(5749):805-10
references.pmid: 16272112
references.citation: Nat Neurosci. 2003 Jul;6(7):750-7
references.pmid: 12808459
references.citation: J Neurosci. 2003 Oct 29;23(30):9873-80
references.pmid: 14586016
references.citation: PLoS Biol. 2009 Oct;7(10):e1000230
references.pmid: 19859539
references.citation: Trends Neurosci. 2007 Jun;30(6):260-7
references.pmid: 17418905
references.citation: Dev Biol. 2001 Jan 15;229(2):271-86
references.pmid: 11203695
references.citation: Science. 2007 May 25;316(5828):1212-6
references.pmid: 17525344
references.citation: Science. 1995 Jul 7;269(5220):98-101
references.pmid: 7541558
references.citation: J Neurosci. 2002 Jul 1;22(13):5473-80
references.pmid: 12097499
references.citation: J Neurosci. 1995 Oct;15(10):6389-402
references.pmid: 7472403
references.citation: Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a001776
references.pmid: 20554703
references.citation: Nature. 1997 Apr 24;386(6627):796-804
references.pmid: 9126737
references.citation: Neuron. 1996 Nov;17(5):849-62
references.pmid: 8938118
references.citation: Nature. 2005 Nov 3;438(7064):94-8
references.pmid: 16267555
references.citation: Nature. 1993 Jun 17;363(6430):630-4
references.pmid: 8510755
references.citation: J Neurosci. 2001 Apr 15;21(8):2749-58
references.pmid: 11306627
references.citation: J Neurosci. 2008 Jan 16;28(3):622-32
references.pmid: 18199763
references.citation: Prog Brain Res. 1994;102:79-93
references.pmid: 7800834
references.citation: Eur J Neurosci. 1995 Feb 1;7(2):198-212
references.pmid: 7757257
references.citation: Nat Rev Neurosci. 2003 Dec;4(12):1002-12
references.pmid: 14618156
references.citation: J Comp Neurol. 1982 Sep 1;210(1):10-29
references.pmid: 7130467
references.citation: Development. 2006 Mar;133(5):845-53
references.pmid: 16439477
references.citation: Development. 2000 Jun;127(12):2549-61
references.pmid: 10821754
references.citation: J Neurosci. 2000 Aug 1;20(15):5802-12
references.pmid: 10908621
references.citation: Neuron. 2003 Jul 31;39(3):453-65
references.pmid: 12895420
references.citation: Cell. 1993 Jan;72 Suppl:77-98
references.pmid: 8428376
references.citation: Nat Rev Neurosci. 2007 Jun;8(6):427-37
references.pmid: 17514196
references.citation: Cereb Cortex. 2007 Mar;17(3):531-41
references.pmid: 16627861
references.citation: Neuron. 1991 Aug;7(2):277-85
references.pmid: 1873031
references.citation: J Neurosci. 2004 Sep 29;24(39):8428-35
references.pmid: 15456815
references.citation: Science. 2004 Apr 2;304(5667):108-10
references.pmid: 15064420
references.citation: Cell. 2008 Aug 8;134(3):508-20
references.pmid: 18692473
references.citation: J Comp Neurol. 2001 May 28;434(2):147-57
references.pmid: 11331522
references.citation: J Neurosci. 1999 Jun 1;19(11):4428-36
references.pmid: 10341244
references.citation: Cereb Cortex. 2009 Jul;19 Suppl 1:i11-21
references.pmid: 19357391
references.citation: J Comp Neurol. 1994 Jun 1;344(1):101-20
references.pmid: 8063952
references.citation: Mech Dev. 2004 Feb;121(2):143-56
references.pmid: 15037316
references.citation: Int J Dev Biol. 2002;46(4):609-19
references.pmid: 12141449
references.citation: J Neurosci. 2006 Jan 18;26(3):882-92
references.pmid: 16421308
references.citation: J Comp Neurol. 1993 Feb 15;328(3):415-36
references.pmid: 8440789
references.citation: J Comp Neurol. 2004 Jan 6;468(2):217-32
references.pmid: 14648681
references.citation: Neuron. 2008 Feb 7;57(3):378-92
references.pmid: 18255031
references.citation: J Neurosci. 2000 Jul 1;20(13):4975-82
references.pmid: 10864955
references.citation: Dev Biol. 2008 Jan 1;313(1):371-83
references.pmid: 18061159
references.citation: Neuron. 2005 Sep 15;47(6):817-31
references.pmid: 16157277
references.citation: Neuron. 1991 Dec;7(6):947-63
references.pmid: 1764246
references.citation: Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1207-12
references.pmid: 17229842
references.citation: Comb Chem High Throughput Screen. 2009 Jul;12(6):580-8
references.pmid: 19601755
references.citation: Curr Top Dev Biol. 2009;87:81-118
references.pmid: 19427517
references.citation: PLoS Biol. 2008 Jun 10;6(6):e142
references.pmid: 18547144
references.citation: Curr Opin Neurobiol. 2008 Feb;18(1):28-35
references.pmid: 18508260
references.citation: Science. 1986 Aug 15;233(4765):740-6
references.pmid: 3738507
references.citation: J Neurobiol. 1992 Sep;23(7):845-54
references.pmid: 1431848
references.citation: Neuron. 1999 Mar;22(3):463-73
references.pmid: 10197527
references.citation: J Neurosci. 2009 Oct 7;29(40):12542-57
references.pmid: 19812329
references.citation: Nat Rev Neurosci. 2005 Jul;6(7):553-64
references.pmid: 15959467
references.citation: J Neurosci. 1995 May;15(5 Pt 2):3716-29
references.pmid: 7751940
references.citation: Nature. 2008 Jan 24;451(7177):465-9
references.pmid: 18216854
references.citation: Neuron. 2009 May 28;62(4):494-509
references.pmid: 19477152
references.citation: Eur J Neurosci. 2004 Apr;19(8):2039-46
references.pmid: 15090031
references.citation: Dev Biol. 2009 Aug 15;332(2):351-9
references.pmid: 19505456
references.citation: Development. 2008 Nov;135(22):3643-53
references.pmid: 18842816
references.citation: Neuron. 2003 Sep 11;39(6):919-35
references.pmid: 12971893
references.citation: Development. 2003 Oct;130(20):4999-5008
references.pmid: 12952902
references.citation: Nature. 1994 Mar 10;368(6467):140-4
references.pmid: 8139655
references.citation: J Comp Neurol. 2005 Mar 21;483(4):375-82
references.pmid: 15700272
references.citation: Neuron. 2008 Feb 28;57(4):511-23
references.pmid: 18304481
references.citation: Development. 2002 Dec;129(23):5389-98
references.pmid: 12403710
references.citation: Nat Rev Neurosci. 2007 Sep;8(9):673-86
references.pmid: 17704810
references.citation: Nat Rev Mol Cell Biol. 2003 Oct;4(10):814-9
references.pmid: 14570063
references.citation: Mol Cell Biol. 2005 Jan;25(2):685-98
references.pmid: 15632069
references.citation: Cell. 1996 Dec 13;87(6):1001-14
references.pmid: 8978605
references.citation: Nat Neurosci. 2007 May;10(5):588-97
references.pmid: 17450135
references.citation: J Comp Neurol. 2008 Jan 20;506(3):387-97
references.pmid: 18041777
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16021-6
references.pmid: 18840685
references.citation: J Neurosci. 2009 Apr 1;29(13):4044-55
references.pmid: 19339600
references.citation: J Comp Neurol. 1998 Sep 21;399(2):176-88
references.pmid: 9721902
references.citation: Prog Neurobiol. 2008 Jun;85(2):214-35
references.pmid: 18378059
references.citation: J Comp Neurol. 2009 May 20;514(3):215-25
references.pmid: 19296474
references.citation: Nature. 2003 Oct 30;425(6961):917-25
references.pmid: 14586460
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11382-7
references.pmid: 18678899
references.citation: Development. 1997 May;124(10):1985-97
references.pmid: 9169845
references.citation: Trends Neurosci. 2003 Sep;26(9):469-76
references.pmid: 12948657
references.citation: Dev Biol. 2006 Aug 15;296(2):485-98
references.pmid: 16836993
references.citation: J Neurosci. 1994 Nov;14(11 Pt 1):6608-20
references.pmid: 7965064
references.citation: J Neurosci. 2003 Sep 3;23(22):8176-84
references.pmid: 12954881
references.citation: Nature. 1989 Feb 2;337(6206):424-8
references.pmid: 2644541
references.citation: Curr Opin Neurobiol. 2009 Apr;19(2):139-45
references.pmid: 19428236
references.citation: Nature. 1991 Sep 19;353(6341):267-70
references.pmid: 1680220
references.citation: Int J Biochem Cell Biol. 2006;38(12):2011-7
references.pmid: 16971168
references.citation: Genes Dev. 2005 Nov 15;19(22):2656-67
references.pmid: 16260494
references.citation: J Comp Neurol. 2008 Jan 10;506(2):240-62
references.pmid: 18022955
references.citation: Neuron. 2002 Jan 17;33(2):233-48
references.pmid: 11804571
references.citation: Neuron. 2005 Oct 6;48(1):63-75
references.pmid: 16202709
references.citation: Nat Neurosci. 2005 Sep;8(9):1151-9
references.pmid: 16116452
references.citation: Brain Res Bull. 2008 Jan 31;75(1):42-52
references.pmid: 18158094
references.citation: Neuron. 2008 Jan 24;57(2):232-47
references.pmid: 18215621
references.citation: Cell. 2006 Apr 7;125(1):127-42
references.pmid: 16615895
references.citation: J Comp Neurol. 2002 Jan 7;442(2):130-55
references.pmid: 11754167
references.citation: Nature. 1997 Jan 2;385(6611):70-4
references.pmid: 8985248
references.citation: Neuron. 2009 Jun 25;62(6):773-80
references.pmid: 19555646
references.citation: Science. 2009 Jan 16;323(5912):388-93
references.pmid: 19150847
references.citation: J Neurosci. 2003 Jan 1;23(1):203-12
references.pmid: 12514217
references.citation: J Neurosci. 2007 Sep 5;27(36):9653-63
references.pmid: 17804626
references.citation: J Comp Neurol. 2009 Jan 10;512(2):158-82
references.pmid: 19003874
references.citation: J Neurosci. 1993 Jan;13(1):285-99
references.pmid: 8423474
references.citation: Neuron. 2008 Feb 7;57(3):364-77
references.pmid: 18255030
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):557-68
references.pmid: 18568015
references.citation: PLoS Biol. 2009 Apr 28;7(4):e98
references.pmid: 19402755
references.citation: Annu Rev Neurosci. 2008;31:479-509
references.pmid: 18558864
references.citation: AJNR Am J Neuroradiol. 2009 Feb;30(2):282-9
references.pmid: 19001538
references.citation: PLoS Comput Biol. 2009 Mar;5(3):e1000334
references.pmid: 19325892
references.citation: Neuron. 1997 Sep;19(3):575-89
references.pmid: 9331350
references.citation: Science. 2003 Jul 25;301(5632):521-5
references.pmid: 12881571
references.citation: J Neurosci. 2000 Aug 1;20(15):5792-801
references.pmid: 10908620
references.citation: Neuron. 2002 Jan 17;33(2):219-32
references.pmid: 11804570
references.citation: Development. 1998 Nov;125(21):4273-82
references.pmid: 9753681
references.citation: Nat Rev Neurosci. 2007 May;8(5):331-40
references.pmid: 17453014
references.citation: Trends Neurosci. 1999 Dec;22(12):529-34
references.pmid: 10542427
references.citation: Science. 1989 Sep 1;245(4921):978-82
references.pmid: 2475909
references.citation: J Neurosci. 2008 Nov 19;28(47):12328-40
references.pmid: 19020026
references.citation: Prog Neurobiol. 2008 May;85(1):75-93
references.pmid: 18304718
references.citation: Nat Neurosci. 2006 Jun;9(6):787-97
references.pmid: 16715082
references.citation: Brain Res Bull. 1991 Dec;27(6):767-89
references.pmid: 1664779
references.citation: Development. 1997 Dec;124(24):5063-74
references.pmid: 9362464