title: The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys.
abstract: The surround suppression of the receptive field is important for basic visual information processing, such as orientation specificity. To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies of the receptive field properties of cells in the primary visual cortex (area V1) in young and old rhesus (Macaca mulatta) monkeys. When presented with the oriented central stimulus, we found that cells in old animals showed reduced orientation and direction selectivity compared with those in young animals. When presented with the oriented central stimulus together with the optimal surround stimulus, more selective cells {orientation bias (OB) >/=0.1; a bias of 0.1 is significant at the P<0.005 level} in animals of both ages showed reduced orientation selectivity compared with the experiment that presented only the oriented central stimulus. When presented with the optimal central stimulus together with the oriented surround stimulus, cells in old animals showed reduced orientation and direction selectivity compared with young animals. Moreover, broadly tuned cells (OB<0.1) in old animals exhibited significantly reduced suppression indices that quantified the strength of the surround suppression of the receptive field, when compared with those in young animals. These results suggest that aging may seriously affect the surround suppression of the receptive field of V1 cells. Thus, the decreased strength of surround suppression of the receptive field may be one possible reason for the decreased stimulus selectivity of V1 cells previously found in the senescent brain. This work will contribute to an understanding of the physiological mechanisms mediating surround suppression of the receptive field.
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fu
authors.forename: X S
authors.initials: XS
authors.lastname: Wang
authors.forename: Y C
authors.initials: YC
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Liang
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhou
authors.forename: Y Y
authors.initials: YY
authors.lastname: Ma
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
references.citation: J Neurophysiol. 2001 Oct;86(4):2011-28
references.pmid: 11600658
references.citation: Neurobiol Aging. 1985 Fall;6(3):193-8
references.pmid: 2932652
references.citation: Vision Res. 1976;16(10):1131-9
references.pmid: 969225
references.citation: Brain Res. 2009 Jun 5;1274:21-7
references.pmid: 19376092
references.citation: Neuron. 2003 Jun 5;38(5):689-99
references.pmid: 12797955
references.citation: Neuron. 2005 Feb 3;45(3):361-6
references.pmid: 15694323
references.citation: Cereb Cortex. 2005 Apr;15(4):403-8
references.pmid: 15749984
references.citation: Vision Res. 1994 Sep;34(18):2337-55
references.pmid: 7975275
references.citation: Vis Neurosci. 2000 May-Jun;17(3):369-79
references.pmid: 10910105
references.citation: Neurobiol Aging. 1981 Fall;2(3):187-92
references.pmid: 7312096
references.citation: Spat Vis. 1997;10(4):433-6
references.pmid: 9176952
references.citation: Nature. 1997 May 1;387(6628):73-6
references.pmid: 9139823
references.citation: J Anat. 1995 Dec;187 ( Pt 3):563-81
references.pmid: 8586556
references.citation: Neurobiol Aging. 2006 Jan;27(1):155-62
references.pmid: 16298251
references.citation: J Neurophysiol. 1992 Apr;67(4):961-80
references.pmid: 1588394
references.citation: Nature. 1998 Feb 5;391(6667):580-4
references.pmid: 9468134
references.citation: J Neurophysiol. 2001 May;85(5):1873-87
references.pmid: 11353004
references.citation: Brain Res. 1978 Jan 13;139(2):359-65
references.pmid: 624064
references.citation: Brain Res. 2006 Nov 29;1122(1):93-8
references.pmid: 17010946
references.citation: J Neurophysiol. 2000 Aug;84(2):909-26
references.pmid: 10938316
references.citation: J Neurosci. 1995 Mar;15(3 Pt 1):1808-18
references.pmid: 7891136
references.citation: J Neurosci. 2003 Aug 20;23(20):7690-701
references.pmid: 12930809
references.citation: Annu Rev Neurosci. 1985;8:407-30
references.pmid: 3885829
references.citation: J Neurosci. 1999 Dec 1;19(23):10536-53
references.pmid: 10575050
references.citation: Neuroscience. 2006 Jul 7;140(3):1023-9
references.pmid: 16678974
references.citation: Neurosci Res. 2002 Jul;43(3):207-20
references.pmid: 12103439
references.citation: Nat Neurosci. 2000 Apr;3(4):384-90
references.pmid: 10725929
references.citation: Brain Cogn. 1996 Feb;30(1):109-26
references.pmid: 8811986
references.citation: Science. 2003 May 2;300(5620):812-5
references.pmid: 12730605
references.citation: Exp Brain Res. 1972;15(4):439-40
references.pmid: 5079475
references.citation: Vision Res. 1993 Dec;33(18):2589-609
references.pmid: 8296455
references.citation: Brain Res Mol Brain Res. 1992 Jun;14(1-2):71-8
references.pmid: 1323020
references.citation: J Vis. 2009 Jan 20;9(1):21.1-11
references.pmid: 19271891
references.citation: J Neurophysiol. 1998 Jun;79(6):3272-8
references.pmid: 9636126
references.citation: J Neurophysiol. 1994 Jan;71(1):347-74
references.pmid: 8158236
references.citation: Exp Brain Res. 1997 Sep;116(2):216-28
references.pmid: 9348122
references.citation: Spat Vis. 1997;10(4):437-42
references.pmid: 9176953
references.citation: Vision Res. 1977;17(9):1001-8
references.pmid: 595408
references.citation: Nat Neurosci. 1999 Aug;2(8):733-9
references.pmid: 10412063
references.citation: Brain Res. 2000 Jul 28;872(1-2):125-33
references.pmid: 10924684
references.citation: J Physiol Paris. 2003 Mar-May;97(2-3):141-54
references.pmid: 14766139
references.citation: Eur J Neurosci. 2008 Jul;28(1):201-7
references.pmid: 18616566
references.citation: J Neurosci. 1994 Dec;14(12):7469-77
references.pmid: 7996188
references.citation: Nature. 1995 Nov 30;378(6556):492-6
references.pmid: 7477405
references.citation: J Neurosci. 2002 Oct 1;22(19):8633-46
references.pmid: 12351737
references.citation: Neurobiol Aging. 1981 Winter;2(4):303-8
references.pmid: 7335148
references.citation: J Neurosci. 2005 Dec 14;25(50):11666-75
references.pmid: 16354925