title: A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes.
abstract: Cytotoxic T lymphocytes (CTLs) play a critical role in the control of various cancers and infections, and therefore the molecular mechanisms of CTL generation are a critical issue in designing antitumor immunotherapy and vaccines which augment the development of functional and long-lasting memory CTLs. Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, acts on naive CD4+ T cells and plays pivotal roles as a proinflammatory cytokine to promote the early initiation of type-1 helper differentiation and also as an antiinflammatory cytokine to limit the T cell hyperactivity and production of pro-inflammatory cytokines. Recent studies revealed that IL-27 plays an important role in CD8+ T cells as well. Therefore, this article reviews current understanding of the role of IL-27 in CD8+ T cell functions and generation of CTLs.
authors.affiliation: Intractable Disease Research Center, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Morishima
authors.forename: Izuru
authors.initials: I
authors.lastname: Mizoguchi
authors.forename: Masae
authors.initials: M
authors.lastname: Okumura
authors.forename: Yukino
authors.initials: Y
authors.lastname: Chiba
authors.forename: Mingli
authors.initials: M
authors.lastname: Xu
authors.forename: Motomu
authors.initials: M
authors.lastname: Shimizu
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsui
authors.forename: Junichiro
authors.initials: J
authors.lastname: Mizuguchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yoshimoto
mesh_terms: D000818:Animals; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D020381:Interleukin-17 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D009928:Organ Specificity / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology* / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D007371:Interferon-gamma
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