The role of CCR5 in HCV infection.
Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes. The CCR5 chemokine receptor is expressed on several cells of the immune system and has been suggested to influence the susceptibility to HCV infection as well as natural course and progression of hepatitis C. However, these reports are still controversial. This review will summarize and discuss the available data regarding the potential role of CCR5 and its ligands in hepatitis C.
Coenen
Martin
M
Department of Internal Medicine I, University of Bonn, Germany.
Nattermann
Jacob
J
D018946:Chemokine CCL5 / Q000502:physiology*; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D006801:Humans; D019713:Receptors, CCR5 / Q000502:physiology*
D018946:Chemokine CCL5; D019713:Receptors, CCR5
Virology. 2002 Nov 25;303(2):253-77
12490388
Am J Transplant. 2008 Mar;8(3):557-66
18294152
Pharmacol Rev. 2000 Mar;52(1):145-76
10699158
J Infect Dis. 2008 Jul 15;198(2):213-7
18500933
J Am Soc Nephrol. 2002 Mar;13(3):754-758
11856781
Nat Rev Cancer. 2004 Jul;4(7):540-50
15229479
Hepatology. 2003 Dec;38(6):1468-76
14647058
Am J Gastroenterol. 2002 Nov;97(11):2861-70
12425561
Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G949-58
12829440
J Exp Med. 2006 Jan 23;203(1):35-40
16418398
J Hepatol. 2010 Feb;52(2):153-9
20044164
Nat Immunol. 2001 Feb;2(2):108-15
11175802
Autoimmun Rev. 2002 Dec;1(6):313-20
12848986
Clin Infect Dis. 2009 Aug 1;49(3):466-72
19580412
J Viral Hepat. 2004 Jul;11(4):319-23
15230854
Eur J Immunogenet. 2004 Dec;31(6):249-52
15548261
Nat Immunol. 2007 Dec;8(12):1324-36
17952079
Gastroenterology. 2000 Feb;118(2):346-55
10648463
Lancet. 2001 Jun 2;357(9270):1758-61
11403814
Nature. 1998 Jan 22;391(6665):344-5
9450746
J Immunol. 1998 Apr 15;160(8):4018-25
9558111
Immunol Invest. 2009;38(1):1-13
19172482
Gastroenterology. 2002 Jun;122(7):1721-8
12055576
Hepatology. 2006 Oct;44(4):945-54
17006905
Science. 1996 Sep 27;273(5283):1856-62
8791590
J Clin Invest. 2009 Jul;119(7):1858-70
19603542
Clin Immunol. 2003 Jul;108(1):46-50
12865070
Transplantation. 2007 Oct 27;84(8):1037-44
17989610
J Antimicrob Chemother. 2004 Jun;53(6):895-8
15128728
Gut. 2005 Aug;54(8):1157-61
15863470
Nat Immunol. 2001 Feb;2(2):95-101
11175800
Hepatology. 2005 Oct;42(4):854-62
16175603
Transplantation. 2004 Nov 15;78(9):1341-50
15548973
Circ Res. 2004 Oct 29;95(9):858-66
15514167
Blood. 2002 Feb 15;99(4):1237-45
11830471
World J Gastroenterol. 2006 Aug 7;12(29):4721-6
16937446
J Hepatol. 2003 Aug;39(2):245-52
12873822
Cell. 1996 Aug 9;86(3):367-77
8756719
J Immunol. 1999 Dec 1;163(11):6236-43
10570316
EMBO J. 2006 Feb 8;25(3):447-56
16437164
J Clin Invest. 1996 Aug 1;98(3):706-14
8698862
J Immunol. 2004 Sep 1;173(5):3287-96
15322191
J Mol Med (Berl). 2004 Jan;82(1):64-9
14673528