title: Ischemia-modified albumin and heart fatty acid-binding protein: could early ischemic cardiac biomarkers be used in acute stroke management?
abstract: BACKGROUND
  The detection of biomarkers such as ischemia-modified albumin (IMA) and heart fatty acid-binding protein (HFABP) is used in the early diagnosis of acute myocardial infarction. As these biomarkers are not organ specific, we tested them in the neurovascular field.
  
  
  METHODS
  A total of 41 patients with acute stroke were enrolled (31 ischemic strokes and 10 intracerebral hemorrhages). IMA and HFABP levels were measured in serum samples collected within 4.5 hours of stroke onset. Clinical, imaging, and outcome data were recorded.
  
  
  RESULTS
  No difference in baseline IMA or HFABP was found between patients with ischemic and hemorrhagic stroke. There was no correlation among biomarker levels at admission, National Institutes of Health Stroke Scale score, or stroke volume. Neither of the biomarkers could predict short-term prognosis.
  
  
  CONCLUSIONS
  IMA and HFABP do not appear to be relevant in acute stroke management.
authors.affiliation: Department of Neurology and Stroke Unit, University Hospital, Nantes, France. fannyherisson@yahoo.fr
authors.forename: Fanny
authors.initials: F
authors.lastname: Herisson
authors.forename: Odile
authors.initials: O
authors.lastname: Delaroche
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Auffray-Calvier
authors.forename: Benjamin Daumas
authors.initials: BD
authors.lastname: Duport
authors.forename: Benoit
authors.initials: B
authors.lastname: Guillon
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000097:blood / Q000175:diagnosis; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D012709:Serum Albumin