Hypoxic regulation of erythropoiesis and iron metabolism.
The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.
Haase
Volker H
VH
Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA. volker.haase@vanderbilt.edu
D000740:Anemia / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004920:Erythropoiesis / Q000187:drug effects / Q000235:genetics; D004921:Erythropoietin / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D005786:Gene Expression Regulation; D006397:Hematinics / Q000627:therapeutic use; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000235:genetics; D007501:Iron / Q000097:blood*; D007668:Kidney / Q000378:metabolism; D010100:Oxygen / Q000097:blood*; D011086:Polycythemia / Q000097:blood / Q000235:genetics; D011393:Procollagen-Proline Dioxygenase / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000097:blood / Q000235:genetics; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D004921:Erythropoietin; D006397:Hematinics; D007501:Iron; D010100:Oxygen; D011393:Procollagen-Proline Dioxygenase; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D000099162:Endothelial PAS Domain-Containing Protein 1
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