title: Boiling water-catalyzed neutral and selective N-Boc deprotection.
abstract: A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.
authors.affiliation: State key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Yan-Liang
authors.initials: YL
authors.lastname: Liang
authors.forename: Jin
authors.initials: J
authors.lastname: Qu
mesh_terms: D002384:Catalysis; D005563:Formic Acid Esters / Q000737:chemistry*; D006358:Hot Temperature; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D005563:Formic Acid Esters; C000345:t-butyloxycarbonyl group; D014867:Water