Use of herbal treatments in pregnancy.
OBJECTIVE
Interest in herbal treatments has increased without data on safety, efficacy, or rates of use in pregnancy. We examined antenatal herbal and natural product use among mothers of nonmalformed infants in 5 geographic centers.


METHODS
We used data on nonmalformed infants from the Slone Epidemiology Center's case-control surveillance program for birth defects to examine rates and predictors of herbal use. Exposures were identified through maternal interview. In addition to overall use, 5 categories based on traditional uses and 2 natural product categories were created; topical products and herbal-containing multivitamins were excluded.


RESULTS
Among 4866 mothers of nonmalformed infants, 282 (5.8%) reported use of herbal or natural treatments. Use varied by study center and increased with increasing age.


CONCLUSIONS
Although rates of use are low, there remains a need for investigation of the safety of these products. Given sparse data on efficacy, even small risks might well outweigh benefits.
Louik
Carol
C
Slone Epidemiology Center, Department of Family Medicine, Boston University, Boston, MA 02215, USA. clouik@bu.edu
Gardiner
Paula
P
Kelley
Katherine
K
Mitchell
Allen A
AA
D000328:Adult; D005260:Female; D006801:Humans; D016015:Logistic Models; D008517:Phytotherapy / Q000706:statistics & numerical data*; D011247:Pregnancy; D014481:United States; D055815:Young Adult
BMC Pregnancy Childbirth. 2006 Jun 19;6:21
16780602
Pharmacoepidemiol Drug Saf. 2007 Apr;16(4):464-8
17063532
Adv Data. 2004 May 27;(343):1-19
15188733
Pharmacoepidemiol Drug Saf. 2004 Jun;13(6):371-80
15170766
Reprod Toxicol. 2007 Jun;23(4):480-5
17287108
Pharmacoepidemiol Drug Saf. 2008 Feb;17(2):151-9
17992658
Obstet Gynecol. 2000 Jan;95(1):19-23
10636495
Obstet Gynecol. 2005 May;105(5 Pt 1):1119-22
15863553
JAMA. 1981 Jun 12;245(22):2311-4
7230459
Am J Perinatol. 2005 Aug;22(6):321-4
16118721
Can J Clin Pharmacol. 2006 Fall;13(3):e277-84
17085776
Can J Clin Pharmacol. 2006 Fall;13(3):e268-76
17085775
Can J Clin Pharmacol. 2006 Fall;13(3):e257-61
17085773
Am J Obstet Gynecol. 2006 Jul;195(1):149-53
16631099
Anesth Analg. 2002 Mar;94(3):690-3; table of contents
11867399
Am J Obstet Gynecol. 2004 Feb;190(2):351-7
14981373
Am J Obstet Gynecol. 2001 Aug;185(2):433-7
11518905
BJOG. 2002 Mar;109(3):227-35
11950176
Am J Med. 2008 Mar;121(3):207-11
18328304
Am J Epidemiol. 1999 Oct 1;150(7):675-82
10512421