Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary gamma-cyclodextrin complex.
A crystalline ternary complex was prepared by sealed-heating of naproxen (NPX) with a flurbiprofen (FBP)/gamma-cyclodextrin (gamma-CD) inclusion complex. The dissolution rates of NPX and FBP in the ternary complex were almost the same, indicating that FBP and NPX from the complex dissolved simultaneously. The ternary CD complex showing a fascinating dissolution property could be a new formulation for combination therapies.
Higashi
Kenjirou
K
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. ken-h@p.chiba-u.ac.jp
Ideura
Saori
S
Waraya
Haruka
H
Limwikrant
Waree
W
Moribe
Kunikazu
K
Yamamoto
Keiji
K
D002626:Chemistry, Pharmaceutical; D005480:Flurbiprofen / Q000737:chemistry*; D015394:Molecular Structure; D009288:Naproxen / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction; D047408:gamma-Cyclodextrins / Q000737:chemistry*
D047408:gamma-Cyclodextrins; D014867:Water; D009288:Naproxen; D005480:Flurbiprofen; C023792:gamma-cyclodextrin