title: Ischemic heart disease associated with bortezomib treatment combined with dexamethasone in a patient with multiple myeloma.
abstract: A 79-year-old female patient with multiple myeloma who had no prior cardiac disease history developed an acute myocardial infarction on day 5 after receiving bortezomib and dexamethasone (BD). After treatment of coronary stenoses by stents, she received another course of BD therapy and developed angina pectoris on day 5 after the therapy. Bortezomib's antitumor effect is due to the inhibition of proteasome activity. This inhibition may increase endothelial progenitor cell apoptosis and decrease endothelial nitric oxide synthase/nitric oxide (eNOS/NO), thus leading to coronary spasm. It is, therefore, important to carefully monitor patients being treated with bortezomib for the potential occurrence of ischemic heart disease.
authors.affiliation: Department of Internal Medicine, NTT WEST Kanazawa Hospital, 6-26 Shimoshinmachi, Kanazawa, Ishikawa, 920-0910, Japan. takamaz@med3.m.kanazawa-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamashita
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kotani
authors.forename: Aiko
authors.initials: A
authors.lastname: Sawazaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Okumura
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001897:Boronic Acids / Q000009:adverse effects*; D000069286:Bortezomib; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy*; D009203:Myocardial Infarction / Q000139:chemically induced*; D011719:Pyrazines / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone
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