title: Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.
abstract: BACKGROUND
  The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR.
  
  
  RESULTS
  A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements > or =200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0+/-1.4 vs 2.6+/-1.1 micromol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002).
  
  
  CONCLUSIONS
  Serum ADMA levels might play a role in EBPR to exercise.
authors.affiliation: Department of Cardiology, Selcuk University Meram School of Medicine Hospital, Meram, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kayrak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacaksiz
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Selim S
authors.initials: SS
authors.lastname: Ayhan
authors.forename: Alparslan
authors.initials: A
authors.lastname: Taner
authors.forename: Ali
authors.initials: A
authors.lastname: Unlü
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
authors.forename: Mehmet S
authors.initials: MS
authors.lastname: Ulgen
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine