PDCD1 gene polymorphisms in different Mexican ethnic groups and their role in the susceptibility to hypersensitivity pneumonitis.
OBJECTIVE
Hypersensitivity pneumonitis (HP) is an immunological disorder caused by antigen exposure in susceptible individuals. The PDCD1 polymorphisms, PD1.3 and PD1.5 have been associated with the susceptibility to inflammatory disorders. This study was conducted to test whether the PD1.3 and PD1.5 polymorphisms are associated with HP in Mexican patients and to explore the distribution of these polymorphisms in different Mexican ethnic groups.


METHODS
We studied 98 Mexican patients with HP and 92 healthy Mexican controls. Also, 156 healthy Amerindian individuals from two ethnic groups were included (96 Mayans and 60 Mayos). Polymorphisms were determined by TaqMan 5' nuclease assays.


RESULTS
Significant differences in the distribution of the PD1.3 and PD1.5 genotypes between HP patients and healthy Mestizo controls were not found. We observed a significantly different distribution of these polymorphisms in Mexican Mestizos when compared to the Amerindians.


CONCLUSIONS
We found no association between PD1 polymorphism and HP; however the distribution of these polymorphisms was different in Mexican Mestizos and Amerindians.
Zúñiga
Joaquín
J
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, 14080, Mexico. joazu@yahoo.com
Torres-García
Diana
D
Jimenez
Luis
L
Ramírez-Martínez
Gustavo
G
Juárez-Nicolás
Francisco
F
Mujica
Fabiola
F
Romero
Lina T
LT
Acuña
Victor
V
Cruz-Lagunas
Alfredo
A
Ruíz-Saavedra
David
D
Ramos
Carlos
C
Montaño
Martha
M
Mendoza-Milla
Criselda
C
Vargas-Alarcón
Gilberto
G
Pardo
Annie
A
Selman
Moises
M
D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000235:genetics* / Q000276:immunology; D015703:Antigens, CD / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000208:ethnology; D018895:Microsatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D061026:Programmed Cell Death 1 Receptor
D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D005819:Genetic Markers; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor