title: Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities.
abstract: Twelve new dibenzocyclooctadiene lignans, marlignans A-L (1-12), together with 16 known compounds, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-12 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques. Compounds 1-12 were evaluated for their anti-HIV activities, of which compounds 3, 6, 8, and 12 showed modest activities with therapeutic index values of 13.2, 15.6, 17.6, and 16.4, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.forename: Yin-Ke
authors.initials: YK
authors.lastname: Li
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032141:Schisandra / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans