Receptive field dynamics underlying MST neuronal optic flow selectivity.
Optic flow informs moving observers about their heading direction. Neurons in monkey medial superior temporal (MST) cortex show heading selective responses to optic flow and planar direction selective responses to patches of local motion. We recorded MST neuronal responses to a 90 x 90 degrees optic flow display and to a 3 x 3 array of local motion patches covering the same area. Our goal was to test the hypothesis that the optic flow responses reflect the sum of the local motion responses. The local motion responses of each neuron were modeled as mixtures of Gaussians, combining the effects of two Gaussian response functions derived using a genetic algorithm, and then used to predict that neuron's optic flow responses. Some neurons showed good correspondence between local motion models and optic flow responses, others showed substantial differences. We used the genetic algorithm to modulate the relative strength of each local motion segment's responses to accommodate interactions between segments that might modulate their relative efficacy during co-activation by global patterns of optic flow. These gain modulated models showed uniformly better fits to the optic flow responses, suggesting that coactivation of receptive field segments alters neuronal response properties. We tested this hypothesis by simultaneously presenting local motion stimuli at two different sites. These two-segment stimuli revealed that interactions between response segments have direction and location specific effects that can account for aspects of optic flow selectivity. We conclude that MST's optic flow selectivity reflects dynamic interactions between spatially distributed local planar motion response mechanisms.
Yu
Chen Ping
CP
Department of Computer Sciences, Rochester Institute of Technology Rochester, Rochester, New York, USA.
Page
William K
WK
Gaborski
Roger
R
Duffy
Charles J
CJ
D000818:Animals; D002211:Capsaicin; D008253:Macaca mulatta; D008839:Microelectrodes; D008959:Models, Neurological; D009038:Motion; D009039:Motion Perception / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D016011:Normal Distribution; D010775:Photic Stimulation; D013702:Temporal Lobe / Q000502:physiology*
C528652:ALGRX-4975; D002211:Capsaicin
J Opt Soc Am A. 1992 Feb;9(2):177-94
1542059
J Neurophysiol. 1988 Aug;60(2):580-603
3171643
J Neurophysiol. 1999 Feb;81(2):596-610
10036263
Neuron. 2004 Jun 24;42(6):993-1001
15207243
J Neurophysiol. 1984 Jan;51(1):16-31
6693933
J Neurosci. 1999 Jun 15;19(12):5074-84
10366640
J Neurophysiol. 1984 Sep;52(3):488-513
6481441
Curr Opin Neurobiol. 2003 Jun;13(3):372-83
12850223
J Neurophysiol. 2000 Aug;84(2):730-43
10938300
J Neurophysiol. 1996 Dec;76(6):4056-68
8985900
J Opt Soc Am A. 1990 Jan;7(1):160-9
2299447
Biol Cybern. 1993;70(2):123-36
8312404
Vision Res. 1996 Oct;36(19):3061-75
8917769
J Neurosci. 2004 Aug 18;24(33):7305-23
15317857
J Comp Neurol. 1990 Jun 15;296(3):462-95
2358548
Nature. 1989 Feb 23;337(6209):734-6
2918907
J Neurophysiol. 1988 Aug;60(2):621-44
3171645
J Neurosci. 1999 Sep 1;19(17):7591-602
10460265
J Neurosci. 1996 Dec 1;16(23):7733-41
8922429
J Neurophysiol. 2003 Apr;89(4):1994-2013
12686576
Vision Res. 1993 Jul;33(11):1481-90
8351820
Annu Rev Neurosci. 1985;8:407-30
3885829
Network. 2007 Dec;18(4):343-74
18360939
Exp Brain Res. 2010 Jan;200(1):51-60
19727690
J Neurosci. 1996 Oct 1;16(19):6265-85
8815907
Nature. 1992 Dec 10;360(6404):583-5
1461280
J Neurophysiol. 1997 Feb;77(2):782-96
9065850
Proc R Soc Lond B Biol Sci. 1980 Jul 17;208(1173):385-97
6106198
J Neurophysiol. 1993 Mar;69(3):902-14
8385201
Vision Res. 1998 Jul;38(14):2155-79
9797976
J Exp Psychol Hum Percept Perform. 1997 Apr;23(2):546-65
9104009
J Neurosci. 1994 Jan;14(1):54-67
8283251
J Neurophysiol. 1989 Sep;62(3):626-41
2769351
Science. 2002 Mar 29;295(5564):2462-5
11923540
J Neurosci. 1995 Feb;15(2):1195-214
7869094
Nature. 1989 Feb 9;337(6207):549-55
2915704
Nat Neurosci. 2004 Jul;7(7):764-72
15195097
Cereb Cortex. 2006 Oct;16(10):1494-507
16339087
J Neurophysiol. 1989 Sep;62(3):642-56
2769352
J Opt Soc Am A. 1987 Aug;4(8):1455-71
3625326
Neural Comput. 1997 Jul 1;9(5):1001-13
9188191
Vision Res. 1994 Nov;34(21):2917-38
7975326
Nature. 1996 Aug 8;382(6591):539-41
8700227
J Comp Neurol. 1986 Jun 8;248(2):190-222
3722458
Eur J Neurosci. 2002 Nov;16(10):1877-86
12453051
J Neurosci. 1986 Jan;6(1):145-57
3944616
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11303-6
7479984
Nature. 1982 Dec 9;300(5892):523-5
7144903
J Neurosci Methods. 1988 Dec;26(2):117-22
3146006
Vision Res. 1980;20(6):535-8
6776685
Cereb Cortex. 2007 Jul;17(7):1722-32
17008413
J Neurosci. 1986 Jan;6(1):134-44
3944614
J Neurophysiol. 1986 Jun;55(6):1308-27
3016210
IEEE Trans Biomed Eng. 1963 Oct;10:137-45
14121113
Nat Neurosci. 2006 Nov;9(11):1421-31
17041595
J Neurosci Methods. 2003 May 30;125(1-2):73-82
12763233
Proc R Soc Lond B Biol Sci. 1980 Feb 29;207(1167):239-48
6102766
J Neurosci. 2008 Dec 17;28(51):13889-906
19091978
Science. 1996 Sep 13;273(5281):1544-7
8703215
Vision Res. 1998 Mar;38(5):743-61
9604103
Vision Res. 2005 Sep;45(19):2481-91
15963549
J Neurophysiol. 1991 Jun;65(6):1346-59
1875244
Percept Psychophys. 1999 Jan;61(1):120-33
10070204
Exp Brain Res. 1997 May;114(3):472-82
9187283
Exp Brain Res. 1989;75(1):53-64
2707356
Neural Comput. 1995 Mar;7(2):290-306
8974732
J Opt Soc Am. 1981 Aug;71(8):953-7
7264778
Neural Netw. 2005 Jun-Jul;18(5-6):549-56
16112546
Network. 2008;19(3):183-212
18946836
J Physiol. 2001 Jun 1;533(Pt 2):447-66
11389204
J Neurosci. 2006 Jan 4;26(1):73-85
16399674
Neural Comput. 2001 Jan;13(1):227-48
11177434
Vis Neurosci. 1992 Sep-Oct;9(3-4):291-302
1390388
J Neurophysiol. 1998 Oct;80(4):1816-27
9772241
Vision Res. 1996 Feb;36(3):431-43
8746233
J Neurophysiol. 1991 Jun;65(6):1329-45
1875243
Eur J Neurosci. 1999 Jul;11(7):2323-31
10383621
J Neurosci. 1995 Jul;15(7 Pt 2):5192-208
7623145
Neural Comput. 1998 Feb 15;10(2):403-30
9472488
J Neurosci. 2006 Dec 27;26(52):13474-84
17192430
Biol Cybern. 2008 Nov;99(4-5):241-51
19011918
Vision Res. 1995 Jun;35(11):1619-31
7667919
J Neurosci. 1997 Apr 15;17(8):2839-51
9092605
Cereb Cortex. 2004 Oct;14(10):1059-70
15115747