Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality.
The zinc finger DHHC domain-containing protein 8 (ZDHHC8) is located in the 22q11 microdeletion region and may contribute to the behavioral deficit associated with 22q11 deletion syndrome. Although polymorphisms of ZDHHC8 have been reported to be associated with the risk of schizophrenia, those associations are still controversial. This study was performed to validate the genetic association of ZDHHC8 polymorphisms with the risk of schizophrenia, and also to scrutinize the association with smooth pursuit eye movement (SPEM) abnormality in a Korean population. Five SNPs of ZDHHC8 were genotyped by TaqMan assay. Their genetic effects on the risk of schizophrenia were analyzed in 354 patients and 396 controls using allele-based chi(2) analyses. Association of ZDHHC8 polymorphisms with SPEM abnormality among 166 schizophrenic patients were analyzed using multiple regressions. No ZDHHC8 polymorphisms were found to be associated with the risk of schizophrenia. However, four SNPs and one haplotype (ht4) were strongly associated with the risk of SPEM abnormality even after multiple correction (P = 0.00005-0.0007, P(corr) = 0.0001-0.002). The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea. hdshin@sogang.ac.kr
Park
Byung Lae
BL
Bae
Joon Seol
JS
Park
Tae Joon
TJ
Chun
Ji Yong
JY
Park
Chul Soo
CS
Sohn
Jin-Wook
JW
Kim
Bong-Jo
BJ
Kang
Yeo-Hwa
YH
Kim
Jae Won
JW
Kim
Ki-Hoon
KH
Shin
Tae-Min
TM
Woo
Sung-Il
SI
D000217:Acyltransferases / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007723:Korea; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011698:Pursuit, Smooth / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
D008565:Membrane Proteins; D000217:Acyltransferases; C488097:ZDHHC8 protein, human