title: Redox biochemistry of hydrogen sulfide.
abstract: H(2)S, the most recently discovered gasotransmitter, might in fact be the evolutionary matriarch of this family, being both ancient and highly reduced. Disruption of gamma-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H(2)S production in the vasculature. However, patients with inherited deficiency in gamma-cystathionase apparently do not present vascular pathology. A mitochondrial pathway disposes sulfide and couples it to oxidative phosphorylation while also exposing cytochrome c oxidase to this metabolic poison. This report focuses on the biochemistry of H(2)S biogenesis and clearance, on the molecular mechanisms of its action, and on its varied biological effects.
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.
authors.forename: Omer
authors.initials: O
authors.lastname: Kabil
authors.forename: Ruma
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D010084:Oxidation-Reduction
chemical_list: D006862:Hydrogen Sulfide
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