Effects of exercise induced oxidative stress on glutathione levels in Parkinson's disease on and off medication.
Resting plasma glutathione (GSH) levels are lower in individuals with Parkinson's disease (PD) than any other neurological condition. Medications used to treat PD have also been shown to further decrease this depletion. Acute exercise has been shown to be an effective tool to produce oxidative stress in other populations as reflected in lowering levels of GSH. The purpose of this study was to determine how PD responds to acute exercise stress and how medication affects these responses. Fourteen men with PD and 14 men without PD underwent an exercise stress test. Subjects with PD performed the test once off PD medication (PD-Off-med) for 12 h then again 1 week later on PD medication (PD-On-med). GSH and glutathione disulfide (GSSG), were collected via blood draws at rest and after peak exercise along with peak VO(2). At rest and at peak exercise GSH levels and the GSH:GSSG ratio were significantly lower in the PD-On-med and PD-Off-med as compared to controls. GSSG levels were significantly higher in both medication conditions at rest and peak exercise compared to controls. When comparing PD-On-med vs. PD-Off-med at rest and peak exercise, the PD-On-med had lower GSH levels, a lower GSH:GSSG ratio and higher GSSG levels. VO(2) correlated positively with GSH levels. Subjects with PD have lower plasma GSH levels than healthy controls at rest and at peak exercise.
Elokda
Ahmed
A
Department of Physical Therapy, New York Institute of Technology, Old Westbury, NY, USA.
DiFrancisco-Donoghue
Joanne
J
Lamberg
Eric M
EM
Werner
William G
WG
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004562:Electrocardiography / Q000379:methods; D015444:Exercise; D005978:Glutathione / Q000097:blood*; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood / Q000503:physiopathology / Q000534:rehabilitation
D005978:Glutathione; D019803:Glutathione Disulfide
Am J Physiol. 1999 Dec;277(6):R1697-704
10600916
Mov Disord. 2009 Sep 15;24(12):1773-8
19562762
Eur J Cardiovasc Prev Rehabil. 2007 Oct;14(5):630-7
17925621
J Strength Cond Res. 2005 May;19(2):276-85
15903362
Ageing Res Rev. 2005 May;4(2):288-314
15936251
Acta Physiol Scand. 1991 Jun;142(2):275-81
1877376
J Rehabil Res Dev. 2000 Sep-Oct;37(5):529-34
11322151
Eur J Biochem. 2000 Aug;267(16):4904-11
10931172
Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):900-10
15998245
Neurology. 1967 May;17(5):427-42
6067254
J Am Coll Cardiol. 2001 Nov 15;38(6):1734-40
11704389
CNS Drugs. 2003;17(10):729-62
12873156
Neurotoxicology. 2002 Oct;23(4-5):479-86
12428720
Med Sci Sports Exerc. 2008 Aug;40(8):1385-9
18614956
Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8
12666096
Neurobiol Dis. 2000 Aug;7(4):240-50
10964596
Med Sci Sports Exerc. 1999 Jun;31(6):761-6
10378900
J Appl Physiol (1985). 1988 Jan;64(1):115-9
3356628
Can J Appl Physiol. 2004 Jun;29(3):245-63
15199226
J Neurol Neurosurg Psychiatry. 2001 Nov;71(5):607-10
11606670
J Appl Physiol (1985). 1994 Nov;77(5):2177-87
7868431
Neurology. 2007 Jan 30;68(5):384-6
17082464
J Neurol Phys Ther. 2006 Jun;30(2):68-73
16796771
J Appl Physiol (1985). 1996 Nov;81(5):2198-202
8941545
Br J Sports Med. 2004 Apr;38(2):143-7; discussion 147
15039248
Mov Disord. 2005;20 Suppl 11:S23-9
15822106
Phys Ther. 1996 Jan;76(1):34-40
8545491
J Cardiopulm Rehabil. 2005 Jul-Aug;25(4):215-9
16056068
Am J Physiol. 1992 Nov;263(5 Pt 2):R992-5
1443237