Hf(OTf)4-catalyzed regioselective n-aminomethylation of indoles and related NH-containing heterocycles.
Under Lewis acidic conditions using Hf(OTf)(4), the aminomethylation of an indole derivative with a typical N,O-acetal preferentially produced kinetically favored N-aminomethylated indole derivatives instead of thermodynamically favored 3-aminomethylated indoles.
Sakai
Norio
N
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan. sakachem@rs.noda.tus.ac.jp
Shimamura
Kazuyori
K
Ikeda
Reiko
R
Konakahara
Takeo
T