title: Antenatal Bartter syndrome: analysis of two cases with placental findings.
abstract: The prenatal diagnosis of Bartter syndrome can be based on the high chloride level in the amniotic fluid. Microscopic examination of the placenta in untreated cases showed extensive mineralization in the chorionic villi in previous studies. Two cases were presented at 26-29 weeks of gestation with severe polyhydramnios. The mothers were treated with Indomethacin, KCl, and serial amniocentesis in order to reduce the amniotic fluid volume and prevent fetal hypokalemia. The microscopic examination of the placenta revealed focal calcification and acute atherosis in placental vessels. The treatment with Indomethacin in the antenatal period can prevent severe nephrocalcinosis.
authors.affiliation: Department of Gynecology & Obstetrics, Haseki Training & Research Hospital, Istanbul, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Dane
authors.forename: Cem
authors.initials: C
authors.lastname: Dane
authors.forename: Figen
authors.initials: F
authors.lastname: Aksoy
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cetin
authors.forename: Murat
authors.initials: M
authors.lastname: Yayla
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000150:complications / Q000473:pathology; D001477:Bartter Syndrome / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002712:Chlorides / Q000032:analysis; D002824:Chorionic Villi / Q000098:blood supply / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000473:pathology* / Q000628:therapy; D005865:Gestational Age; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D009397:Nephrocalcinosis / Q000473:pathology / Q000517:prevention & control; D010922:Placenta Diseases / Q000473:pathology* / Q000628:therapy; D006831:Polyhydramnios / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D011189:Potassium Chloride / Q000627:therapeutic use; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002712:Chlorides; D011189:Potassium Chloride; D007213:Indomethacin