title: Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels.
abstract: OBJECTIVE
  We have reported that serum glycated albumin (GA) levels are low in obese subjects, smokers and hyperuricemic subjects in whom high sensitive CRP (hs-CRP) is elevated. Because patients with nonalcoholic fatty liver disease with high alanine aminotransferase (ALT) levels are reported to show high levels of hs-CRP, the relationship between serum ALT and serum GA levels was investigated.
  
  
  METHODS
  This study comprised 196 non-diabetic men without drinking habit.
  
  
  RESULTS
  Compared with the normal ALT group (serum ALT < or =30 U/L; n=158), the high ALT group (serum ALT >30 U/L; n=38) had significantly higher fasting plasma glucose (PG), OGTT 2-h PG and HbA(1C) levels. Meanwhile, serum GA was significantly lower, and hs-CRP was significantly higher in the high ALT group.
  
  
  CONCLUSIONS
  The results obtained indicate that serum GA is under a negative control of hs-CRP in subjects with high ALT without drinking habit.
authors.affiliation: Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. koga_m@kich.itami.hyogo.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
authors.forename: Jun
authors.initials: J
authors.lastname: Murai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Mikio
authors.initials: M
authors.lastname: Mukai
authors.forename: Soji
authors.initials: S
authors.lastname: Kasayama
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005234:Fatty Liver / Q000097:blood* / Q000201:enzymology / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D033461:Hyperuricemia / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*; D012907:Smoking / Q000097:blood / Q000378:metabolism; D000093423:Glycated Serum Albumin
chemical_list: D000410:Alanine Transaminase; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin