Regulation of inflammasome activity.
Interleukin-1beta (IL-1beta) is a potent inflammatory cytokine, which is implicated in acute and chronic inflammatory disorders. The activity of IL-1beta is regulated by the proteolytic cleavage of its inactive precursor resulting in the mature, bioactive form of the cytokine. Cleavage of the IL-1beta precursor is performed by the cysteine protease caspase-1, which is activated within protein complexes termed 'inflammasomes'. To date, four distinct inflammasomes have been described, based on different core receptors capable of initiating complex formation. Both the host and invading pathogens need to control IL-1beta production and this can be achieved by regulating inflammasome activity. However, we have, as yet, little understanding of the mechanisms of this regulation. In particular the negative feedbacks, which are critical for the host to limit collateral damage of the inflammatory response, remain largely unexplored. Recent exciting findings in this field have given us an insight into the potential of this research area in terms of opening up new therapeutic avenues for inflammatory disorders.
Guarda
Greta
G
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. Greta.Guarda@unil.ch
So
Alexander
A
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D053583:Interleukin-1beta / Q000276:immunology* / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D053583:Interleukin-1beta
Nature. 2009 Mar 26;458(7237):509-13
19158676
Annu Rev Immunol. 2009;27:229-65
19302040
PLoS One. 2009 Aug 04;4(8):e6510
19652710
Mol Cell. 2002 Aug;10(2):417-26
12191486
Nat Immunol. 2007 Sep;8(9):942-9
17676045
Trends Cell Biol. 2009 Sep;19(9):455-64
19716304
Cell Death Differ. 2007 Aug;14(8):1457-66
17431422
Mol Cell. 2007 Oct 26;28(2):214-27
17964261
Nat Immunol. 2008 Oct;9(10):1171-8
18724372
Nature. 2009 May 21;459(7245):433-6
19339971
Trends Microbiol. 2005 Aug;13(8):381-8
15994078
Science. 1997 Jan 10;275(5297):206-9
8999548
Nature. 2006 Jul 6;442(7098):39-44
16823444
Immunity. 2000 May;12(5):581-90
10843390
Int Immunol. 2004 Feb;16(2):335-43
14734619
J Exp Med. 2006 Jun 12;203(6):1407-12
16717117
J Exp Med. 2000 Jul 17;192(2):249-58
10899911
Nature. 2006 Mar 9;440(7081):237-41
16407889
J Immunol. 1985 Nov;135(5):3205-16
2413115
Immunity. 2009 Jun 19;30(6):860-74
19501001
Immunity. 2006 Mar;24(3):317-27
16546100
Nature. 2006 Apr 20;440(7087):1064-8
16625199
Immunity. 2009 Apr 17;30(4):556-65
19362020
Mol Cell. 2007 Mar 9;25(5):713-24
17349957
Nature. 2006 Mar 9;440(7081):228-32
16407890
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7
16785446
J Biol Chem. 2001 Jul 27;276(30):28309-13
11390368
J Immunol. 2009 Oct 15;183(8):5208-20
19783673
J Immunol. 2008 Sep 15;181(6):3755-9
18768827
Biochem J. 2003 Jul 1;373(Pt 1):101-13
12656673
Bone. 2006 Jan;38(1):41-7
16122996
Annu Rev Immunol. 2002;20:197-216
11861602
Ann Rheum Dis. 2006 Apr;65(4):542-4
16096327
Arthritis Res Ther. 2007;9(2):R28
17352828
PLoS Pathog. 2007 Aug 10;3(8):e111
17696608
J Mol Biol. 2004 Oct 8;343(1):1-28
15381417
Physiology (Bethesda). 2009 Dec;24:325-31
19996363
Nature. 2004 Jul 8;430(6996):213-8
15190255
Cell Host Microbe. 2009 May 8;5(5):487-97
19454352
J Exp Med. 2000 May 1;191(9):1535-44
10790428
Nat Rev Microbiol. 2009 Feb;7(2):99-109
19148178
Immunol Rev. 2008 Jun;223:39-59
18613829
Mol Cell. 2003 Mar;11(3):591-604
12667444
N Engl J Med. 2009 Jun 4;360(23):2416-25
19494217
Ann Rheum Dis. 2009 Oct;68(10):1613-7
19635719
Nat Immunol. 2010 Feb;11(2):136-40
20023662
Nature. 2004 May 6;429(6987):75-9
15129283
Cell. 1992 May 15;69(4):597-604
1339309
Biochem J. 1999 Sep 15;342 Pt 3:655-65
10477277
Cell. 1998 Feb 20;92(4):501-9
9491891
Science. 1995 Mar 31;267(5206):2000-3
7535475
Nature. 2009 Jul 9;460(7252):269-73
19494813
Arthritis Rheum. 2004 Feb;50(2):607-12
14872505
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13501-6
14595024
J Immunol. 2007 Mar 15;178(6):3837-45
17339483
Biochem Soc Trans. 2007 Dec;35(Pt 6):1508-11
18031255
Nat Genet. 2001 Nov;29(3):301-5
11687797
Nature. 2009 Mar 26;458(7237):514-8
19158675
N Engl J Med. 2007 Apr 12;356(15):1517-26
17429083
Nat Genet. 2006 Feb;38(2):240-4
16429160
Immunity. 2004 Mar;20(3):319-25
15030775
Cell Death Differ. 2007 Jan;14(1):10-22
16977329
J Exp Med. 2005 Oct 17;202(8):1043-9
16230474
Immunity. 2009 Apr 17;30(4):566-75
19362023
Cell. 1995 Feb 10;80(3):401-11
7859282
J Exp Med. 2009 Jan 16;206(1):79-87
19139171
Exp Cell Res. 2005 Aug 1;308(1):1-17
15896773
Blood. 2006 Apr 15;107(8):3350-8
16397132
Science. 2009 Feb 20;323(5917):1057-60
19131592
Cell Host Microbe. 2008 Apr 17;3(4):224-32
18407066
J Endotoxin Res. 2004;10(4):201-22
15373964
Mol Cell Proteomics. 2008 Dec;7(12):2350-63
18667412
Cell. 2007 Sep 7;130(5):918-31
17803913
Cell. 2007 Apr 6;129(1):45-56
17418785
J Immunol. 2009 Sep 15;183(6):3578-81
19684085
Nature. 1997 Apr 10;386(6625):619-23
9121587
J Mol Evol. 2008 Jun;66(6):591-7
18473111
Immunity. 2005 Dec;23(6):587-98
16356857
Nat Immunol. 2009 Mar;10(3):266-72
19158679