title: alpha-catenin mechanosensing for adherens junctions.
abstract: The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation.
authors.affiliation: Thomas Lecuit is in IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy, Case 907. 13288 Marseille Cedex 09, France. lecuit@ibdml.univ-mrs.fr
authors.forename: Thomas
authors.initials: T
authors.lastname: Lecuit
mesh_terms: D000199:Actins / Q000378:metabolism; D022005:Adherens Junctions / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D015820:Cadherins / Q000378:metabolism / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009024:Morphogenesis; D051178:alpha Catenin / Q000378:metabolism*
chemical_list: D000199:Actins; D015820:Cadherins; D016023:Integrins; D051178:alpha Catenin
references.citation: Cell. 2001 Feb 23;104(4):605-17
references.pmid: 11239416
references.citation: J Cell Biol. 2002 Nov 25;159(4):695-705
references.pmid: 12446745
references.citation: Cell. 2005 Dec 2;123(5):769-72
references.pmid: 16325573
references.citation: Cell. 1997 Jan 10;88(1):39-48
references.pmid: 9019403
references.citation: Development. 2005 Sep;132(18):4165-78
references.pmid: 16123312
references.citation: Nature. 2004 Jun 10;429(6992):667-71
references.pmid: 15190355
references.citation: Dev Cell. 2009 Nov;17(5):736-43
references.pmid: 19879198
references.citation: J Cell Biol. 2010 Mar 8;188(5):735-49
references.pmid: 20194639
references.citation: Science. 2009 Jan 30;323(5914):638-41
references.pmid: 19179532
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
references.pmid: 18093941
references.citation: Cell. 2005 Dec 2;123(5):889-901
references.pmid: 16325582
references.citation: Nature. 2008 Jun 5;453(7196):751-6
references.pmid: 18480755
references.citation: Curr Top Dev Biol. 2009;89:33-54
references.pmid: 19737641
references.citation: J Cell Biol. 2010 Apr 19;189(2):339-52
references.pmid: 20404114