Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom.
We assessed the relationship between strain type, clinical factors, and outcome in 128 patients with Clostridium difficile infection. Strain type was not associated with any outcome measure. On multivariate analysis, ischemic heart disease and hypoalbuminemia predicted death. Metronidazole treatment in severe disease was associated with a higher rate of treatment failure and death.
Wilson
Vhairi
V
Department of Microbiology and Infection, Brighton and Sussex University Hospitals National Health Service Trust, UK.
Cheek
Liz
L
Satta
Giovanni
G
Walker-Bone
Karen
K
Cubbon
Marc
M
Citron
Diane
D
Gerding
Dale N
DN
Llewelyn
Martin J
MJ
D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects; D016360:Clostridioides difficile / Q000145:classification*; D003015:Clostridium Infections / Q000382:microbiology / Q000401:mortality*; D005243:Feces / Q000382:microbiology; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
D000890:Anti-Infective Agents; D008795:Metronidazole