title: [Progress in Tripterygium wilfordiiand its bioactive components in the field of pharmacodynamics and pharmacology].
abstract: In the trials of multi-glycoside of Tripterygium wilfordii (GTW) in the field of pharmacodynamics, some clinical characteristics and symptoms, such as proteinuria, hematuria,joint pain, and skin damage, could be improved in the patients with various diseases including proliferative glomerulonephritis, lupus nephritis, rheumatoid arthritis, psoriasis and other immune-related diseases. In this review, it has been also reported to discuss the effects of GTW and Triptolide (T4), which is a bioactive component in GTW on anti-inflammatory, immunosuppression, and protection of epithelial cell in kidney. On the other hand, it is possible to have some beneficial effects on organ transplant rejection, tumor growth and anti-fertility.
authors.affiliation: Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210008, China. mrross@163.com
authors.forename: Guangxing
authors.initials: G
authors.lastname: Shui
authors.forename: Yigang
authors.initials: Y
authors.lastname: Wan
authors.forename: Chunming
authors.initials: C
authors.lastname: Jiang
authors.forename: Huilan
authors.initials: H
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Chaojun
authors.initials: C
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D035843:Biomedical Research; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D010600:Pharmacology; D029757:Tripterygium / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal