title: Positively charged bioactive Ti metal prepared by simple chemical and heat treatments.
abstract: A highly bioactive bone-bonding Ti metal was obtained when Ti metal was simply heat-treated after a common acid treatment. This bone-bonding property was ascribed to the formation of apatite on the Ti metal in a body environment. The formation of apatite on the Ti metal was induced neither by its surface roughness nor by the rutile phase precipitated on its surface, but by its positively charged surface. The surface of the Ti metal was positively charged because acid groups were adsorbed on titanium hydride formed on the Ti metal by the acid treatment, and remained even after the titanium hydride was transformed into titanium oxide by the subsequent heat treatment. These results provide a new principle based on a positively charged surface for obtaining bioactive materials.
authors.affiliation: Department of Biomedical Sciences, Chubu University, Kasugai, Japan. kokubo@isc.chubu.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kokubo
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Pattanayak
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takadama
authors.forename: Tomiharu
authors.initials: T
authors.lastname: Matsushita
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Takemoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000327:Adsorption; D000818:Animals; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D006358:Hot Temperature; D006851:Hydrochloric Acid / Q000737:chemistry*; D008297:Male; D010012:Osteogenesis; D011817:Rabbits; D013464:Sulfuric Acids / Q000737:chemistry*; D013499:Surface Properties; D013977:Tibia / Q000737:chemistry* / Q000254:growth & development; D014025:Titanium / Q000737:chemistry*
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D013464:Sulfuric Acids; C009495:titanium dioxide; D014025:Titanium; C033158:sulfuric acid; D006851:Hydrochloric Acid
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