title: Hypertrophic cardiomyopathy with restrictive phenotype and myocardial crypts.
abstract: This report describes a 22-year-old woman who has clinical and physiologic features of a restrictive cardiomyopathy. Magnetic resonance imaging showed myocardial delayed enhancement and interventricular septal crypts characteristic of hypertrophic cardiomyopathy (HCM). Transcatheter biopsy confirmed the diagnosis, revealing marked myocyte hypertrophy, interstitial fibrosis, and fiber disarray, which are findings consistent with HCM. A review of the literature suggests that this is the first case of HCM reported with a restrictive pattern and myocardial crypts.
authors.affiliation: Department of Radiology, University of Rome Sapienza, Viale Regina Elena, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cannavale
authors.forename: Karen G
authors.initials: KG
authors.lastname: Ordovás
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Rame
authors.forename: Charles B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000328:Adult; D001706:Biopsy; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology* / Q000601:surgery; D002313:Cardiomyopathy, Restrictive / Q000473:pathology* / Q000601:surgery; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D016027:Heart Transplantation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D009206:Myocardium / Q000473:pathology; D010641:Phenotype; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA