title: N-trimethylsilyloxyenamines as new aldehyde enolate synthons: general, efficient and diastereoselective aldol reaction with ketals and acetals.
abstract: (E)-N-trimethylsilyloxyenamines, easily accessible from aldonitrones, proved to be excellent nucleophiles in TMSOTf-induced diastereoselective aldol reaction, both with ketals and acetals, proceeding via an extended transition state and leading to a new aldol C-C-bond in the aldonitrone products, that can be readily hydrolysed to the corresponding aldehydes.
authors.affiliation: Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, v. v. i., Flemingovo nam. 2, 16610 Prague 6, Czech Republic.
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Sonawane
authors.forename: Ivana
authors.initials: I
authors.lastname: Císarová
authors.forename: Ilya M
authors.initials: IM
authors.lastname: Lyapkalo