[Study on effect of total flavonoids from Scutellaria amoena on experimental arrhythmia].
OBJECTIVE
To observe the effect of total flavonoids from Scutellaria amoena on the experimental arrhythmia.


METHODS
Experimental animals anesthetized with 10% chloral hydrate were evenly randomized into control group, positive control group, and low-dose, middle-dose and high-dose total flavonoids groups. The experimental arrhythmia ouabain-induced in guinea pigs and barium chloride or calcium chloride-induced in rats were observed and detected respectively. The result was converted into cumulative dosage of ouabain, in guinea pig model. In rat model, the duration of arrhythmia were detected.


RESULTS
hold dosage of ventricular premature heat (VP) and ventricular fibrillation( VF) ouabain-induced in guinea pigs was markedly elevated, and the duration of ventricular tachycardia (VT) barium chloride-induced and VF calcium chloride-induced in rats was postponed by total flavonoids from S. amoena.


CONCLUSIONS
Total flavonoids from S. amoena has obvious protective effect on drug-induced arrhythmia.
He
Xiaoshan
X
Yunnan University of Traditional Chinese Medicine, Kunming 650200, China. hexshjyh74@sina.com
Zhou
Ningna
N
Lin
Qing
Q
Yu
Zepu
Z
Dai
Ron
R
Ai
Kesong
K
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage*; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031363:Scutellaria / Q000737:chemistry*
D000889:Anti-Arrhythmia Agents; D005419:Flavonoids; D010936:Plant Extracts