title: Molecular pathology and patient care.
abstract: Laboratory testing focused on the genetic basis of disease has become an increasingly important part of the analysis of tissue specimens traditionally evaluated only by histopathologic examination. Molecular laboratory testing in surgical pathology is usually only discussed in the context of its role in diagnosis, but genetic techniques have attained an increasingly prominent role in testing to predict prognosis, to identify likelihood of response to various treatment options, to monitor for minimal residual disease, and to identify disease predispositions.
authors.affiliation: Department of Pathology and Immunology at Washington University School of Medicine, St. Louis, USA. pfeifer@path.wustl.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Pfeifer
mesh_terms: D003582:Cytogenetics; D020869:Gene Expression Profiling; D006801:Humans; D017403:In Situ Hybridization; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D057089:Pathology, Molecular; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014015:Tissue Banks
references.citation: Methods Mol Biol. 2009;507:3-20
references.pmid: 18987802
references.citation: J Clin Oncol. 1998 Apr;16(4):1248-55
references.pmid: 9552022
references.citation: N Biotechnol. 2009 Apr;25(4):195-203
references.pmid: 19429539
references.citation: Lancet. 2009 Jul 25;374(9686):340-50
references.pmid: 19535135
references.citation: FEBS J. 2009 Apr;276(8):2157-64
references.pmid: 19250312
references.citation: Appl Immunohistochem Mol Morphol. 2008 Oct;16(5):485-92
references.pmid: 18594471
references.citation: Biotechniques. 2008 Apr;44(5):619-26
references.pmid: 18474036
references.citation: N Engl J Med. 2009 Sep 10;361(11):1058-66
references.pmid: 19657110
references.citation: J Mol Diagn. 2008 Nov;10(6):484-92
references.pmid: 18832462
references.citation: Nucleic Acids Res. 2007;35(12):e85
references.pmid: 17576663
references.citation: Science. 2007 Nov 16;318(5853):1108-13
references.pmid: 17932254
references.citation: Am J Pathol. 2002 Dec;161(6):1961-71
references.pmid: 12466110
references.citation: N Engl J Med. 2004 Dec 30;351(27):2817-26
references.pmid: 15591335
references.citation: Curr Pharm Biotechnol. 2009 Feb;10(2):161-5
references.pmid: 19199948
references.citation: Annu Rev Biomed Eng. 2007;9:289-320
references.pmid: 17391067
references.citation: Am J Surg Pathol. 2002 Aug;26(8):965-77
references.pmid: 12170083
references.citation: Hum Pathol. 2000 May;31(5):532-8
references.pmid: 10836292
references.citation: Dis Markers. 2007;23(1-2):97-104
references.pmid: 17325429
references.citation: J Natl Cancer Inst. 2006 Sep 6;98(17):1183-92
references.pmid: 16954471
references.citation: J Intern Med. 2008 Apr;263(4):366-75
references.pmid: 18298485
references.citation: CA Cancer J Clin. 2009 Sep-Oct;59(5):303-13
references.pmid: 19729680
references.citation: Gastroenterology. 2008 Nov;135(5):1466-8
references.pmid: 18848555
references.citation: Int J Biochem Cell Biol. 2009 Jan;41(1):127-35
references.pmid: 18771747
references.citation: Drug Discov Today. 2005 Feb 1;10(3):205-12
references.pmid: 15708535