Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease.
OBJECTIVE
To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease.


METHODS
Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test.


RESULTS
There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations.


CONCLUSIONS
Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.
Rosoky
Ruben Miguel Ayzin
RM
Department of Vascular and Endovascular Surgery, Faculdade de Medicina da Universidade de São Paulo, Hospital das Clínicas, São Paulo, Brazil.
Wolosker
Nelson
N
Nasser
Michel
M
Zerati
Antonio Eduardo
AE
Gidlund
Magnus
M
Puech-Leão
Pedro
P
D000368:Aged; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D003324:Coronary Artery Disease / Q000503:physiopathology; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000503:physiopathology; D007511:Ischemia / Q000097:blood / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008077:Lipoproteins, LDL / Q000097:blood / Q000502:physiology; D008297:Male; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000503:physiopathology; D011237:Predictive Value of Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
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