Sudden unexpected death in epilepsy.
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of death for people with epilepsy. Recent research suggests that multiple factors may contribute and that both cardiac and respiratory mechanisms are involved. Both human and animal data suggest that specific genetic factors might play a role in some cases. Recent animal data suggest that serotonin might affect respiratory mechanisms and may be involved. Both cardiac and respiratory abnormalities are more likely with generalized tonic-clonic seizures. Uncontrolled epilepsy, particularly with generalized tonic-clonic seizures, appears to be the most highly associated modifiable risk factor for SUDEP.
Nei
Maromi
M
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Jefferson Medical College, 900 Walnut Street, Suite 200, Philadelphia, PA 19107, USA. maromi.nei@jefferson.edu
Hays
Ryan
R
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D003645:Death, Sudden / Q000453:epidemiology / Q000209:etiology*; D003933:Diagnosis; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality*; D006801:Humans; D012307:Risk Factors
D000927:Anticonvulsants
Epilepsia. 1993 Jul-Aug;34(4):597-603
8330567
Epilepsia. 2005;46 Suppl 11:49-53
16393181
Lancet. 1999 Mar 13;353(9156):888-93
10093982
Seizure. 2009 Mar;18(2):158-60
18752973
Epilepsia. 2010 Feb;51(2):233-42
19817816
Epilepsia. 2000 Nov;41(11):1494-7
11077466
Neurology. 2007 Jul 31;69(5):434-41
17664402
Epilepsia. 2000 May;41(5):542-8
10802759
Epilepsy Curr. 2009 Jul-Aug;9(4):91-5
19693322
Am J Forensic Med Pathol. 2002 Dec;23(4):307-14
12464802
Lancet. 2004 Dec 18-31;364(9452):2212-9
15610808
Ther Drug Monit. 1998 Jun;20(3):309-12
9631928
Neurology. 2001 Aug 14;57(3):430-4
11502908
Epilepsia. 1995 Dec;36(12):1187-94
7489695
Lancet. 2002 Jun 1;359(9321):1891-5
12057550
Seizure. 2003 Oct;12(7):456-64
12967573
Neurology. 2009 May 12;72(19):1702-3
19433745
Epilepsy Behav. 2007 Feb;10(1):138-41
17196884
Neurology. 2003 Feb 11;60(3):395-9
12578917
Seizure. 2004 Oct;13(7):523-8
15324833
Epilepsia. 2000 Jan;41(1):42-7
10643922
Epilepsia. 2009 Dec;50(12):2557-62
19682029
Arch Neurol. 1986 Feb;43(2):194-6
3947265
Neurology. 2008 Nov 11;71(20):1572-8
18565827
Epilepsy Res. 2010 Feb;88(2-3):183-8
20018491
J Clin Neurosci. 2000 Jan;7(1):34-7
10847648
Epilepsia. 2004 Apr;45(4):338-45
15030496
Seizure. 1993 Dec;2(4):287-90
8162397
J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):751-2
12438483
J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):211-3
10644790
Neuropathol Appl Neurobiol. 2003 Apr;29(2):132-43
12662321
Ann Neurol. 1981 May;9(5):458-64
7271241
Epilepsia. 2006 Jan;47(1):21-6
16417527
Epilepsy Behav. 2009 Feb;14(2):280-7
19130900
Neurology. 2009 Jan 20;72(3):224-31
19038855
Seizure. 1996 Mar;5(1):79-83
8777558
J Forensic Sci. 1998 May;43(3):598-603
9608695
Epilepsy Behav. 2009 Feb;14(2):404-6
19110074
Epilepsia. 2010 Feb;51(2):289-92
19694797
Brain. 2008 Dec;131(Pt 12):3239-45
18952672
Neurology. 1998 Nov;51(5):1270-4
9818844
Epilepsia. 1992 Mar-Apr;33(2):310-6
1547760
Lancet Neurol. 2008 Nov;7(11):1021-31
18805738
Epilepsia. 2002 Feb;43(2):170-4
11903464
Sleep. 2008 Aug;31(8):1071-8
18714778
Neurology. 2001 Nov 13;57(9):1650-4
11706106
Neurology. 2005 Apr 12;64(7):1131-3
15824334
Acta Neurol Scand. 2007 Mar;115(3):199-203
17295716
Sci Transl Med. 2009 Oct 14;1(2):2ra6
20368164
Curr Neurol Neurosci Rep. 2007 Jul;7(4):335-41
17618541
Epilepsia. 2008 Jan;49(1):168-71
17900291
Epilepsy Res. 2002 Dec;52(2):117-27
12458028
J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1395-7
17389715
J Neurol Neurosurg Psychiatry. 1996 Mar;60(3):297-300
8609507
Neurology. 2000 Feb 22;54(4):903-8
10690984
Epilepsia. 2010 May;51(5):773-6
19863581
Neurology. 2001 Feb 27;56(4):519-25
11222798
Arch Neurol. 1998 Jun;55(6):857-60
9626779
Epilepsia. 1999 Dec;40(12):1795-8
10612346
Epilepsia. 2008 Dec;49(12):2113-7
18801039
Epilepsy Res. 2005 Jan;63(1):67-75
15716033
Epilepsia. 1997 Jan;38(1):47-55
9024183
Epilepsia. 2004 Aug;45(8):993-6
15270769
Acta Paediatr. 2005 May;94(5):564-7
16188745
Seizure. 2007 Mar;16(2):153-9
17178458