title: Hydrolysable tannins depress cardiac papillary muscle contraction and propranolol-induced negative inotropism.
abstract: We studied effects of hydrolysable tannins on rat papillary muscle contractions induced by propranolol. The developed force of papillary muscle was measured isometrically with an inductive force transducer. The IC(50) values for digallic acid, gallic acid, germin D, praecoxin A and 1-desgalloyl rugosin F were 4.2 x 10(-5) M, 1.3 x 10(-4) M, 1,4 x 10(-4) M, 1.5 x 10(-4) and 1.7 x 10(-4) M, respectively. Incubation with tannins significantly attenuated the propranolol-induced negative inotropic contractile response. These results show that hydrolysable tannins depress muscle contractions and potentiate the activities of β-adrenergic blocker.
authors.affiliation: Division of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Hobeom
authors.initials: H
authors.lastname: Lee
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Lee
authors.forename: Moo Hyun
authors.initials: MH
authors.lastname: Suh
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Sim
authors.forename: Min-Won
authors.initials: MW
authors.lastname: Lee
authors.forename: Chang Jong
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D029401:Betulaceae / Q000737:chemistry*; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000319:Adrenergic beta-Antagonists; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D011433:Propranolol