title: Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease.
abstract: OBJECTIVE
  To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease.
  
  
  METHODS
  Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test.
  
  
  RESULTS
  There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations.
  
  
  CONCLUSIONS
  Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.
authors.affiliation: Department of Vascular and Endovascular Surgery, Faculdade de Medicina da Universidade de São Paulo, Hospital das Clínicas, São Paulo, Brazil.
authors.forename: Ruben Miguel Ayzin
authors.initials: RM
authors.lastname: Rosoky
authors.forename: Nelson
authors.initials: N
authors.lastname: Wolosker
authors.forename: Michel
authors.initials: M
authors.lastname: Nasser
authors.forename: Antonio Eduardo
authors.initials: AE
authors.lastname: Zerati
authors.forename: Magnus
authors.initials: M
authors.lastname: Gidlund
authors.forename: Pedro
authors.initials: P
authors.lastname: Puech-Leão
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D003324:Coronary Artery Disease / Q000503:physiopathology; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000503:physiopathology; D007511:Ischemia / Q000097:blood / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008077:Lipoproteins, LDL / Q000097:blood / Q000502:physiology; D008297:Male; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000503:physiopathology; D011237:Predictive Value of Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
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