title: Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary gamma-cyclodextrin complex.
abstract: A crystalline ternary complex was prepared by sealed-heating of naproxen (NPX) with a flurbiprofen (FBP)/gamma-cyclodextrin (gamma-CD) inclusion complex. The dissolution rates of NPX and FBP in the ternary complex were almost the same, indicating that FBP and NPX from the complex dissolved simultaneously. The ternary CD complex showing a fascinating dissolution property could be a new formulation for combination therapies.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. ken-h@p.chiba-u.ac.jp
authors.forename: Kenjirou
authors.initials: K
authors.lastname: Higashi
authors.forename: Saori
authors.initials: S
authors.lastname: Ideura
authors.forename: Haruka
authors.initials: H
authors.lastname: Waraya
authors.forename: Waree
authors.initials: W
authors.lastname: Limwikrant
authors.forename: Kunikazu
authors.initials: K
authors.lastname: Moribe
authors.forename: Keiji
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D002626:Chemistry, Pharmaceutical; D005480:Flurbiprofen / Q000737:chemistry*; D015394:Molecular Structure; D009288:Naproxen / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D047408:gamma-Cyclodextrins; D014867:Water; D009288:Naproxen; D005480:Flurbiprofen; C023792:gamma-cyclodextrin