title: Nontuberculous mycobacterial blood stream and cardiac infections in patients without HIV infection.
abstract: Nontuberculous mycobacteria rarely cause bacteremia in HIV-negative patients. We describe 16 cases, including the first Mycobacterium neoaurum endocarditis. Nine cases were line related. Most patients were immunocompromised secondary to hematologic malignancy or other comorbid conditions. Amikacin had the most reliable in vitro activity. Combination therapy was frequently used. Mortality was 25%.
authors.affiliation: Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH 44195, USA. vanduid@ccf.org
authors.forename: David
authors.initials: D
authors.lastname: van Duin
authors.forename: Johanna
authors.initials: J
authors.lastname: Goldfarb
authors.forename: Steven K
authors.initials: SK
authors.lastname: Schmitt
authors.forename: J Walton
authors.initials: JW
authors.lastname: Tomford
authors.forename: Marion J
authors.initials: MJ
authors.lastname: Tuohy
authors.forename: Geraldine S
authors.initials: GS
authors.lastname: Hall
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D004359:Drug Therapy, Combination / Q000379:methods; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009161:Mycobacterium / Q000145:classification / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality
chemical_list: D000900:Anti-Bacterial Agents