title: [Early antibiotic treatment for eradication of initial infection by Pseudomonas aeruginosa in patients with cystic fibrosis].
abstract: BACKGROUND
  Cystic fibrosis is a genetic autosomal recessive disease that affects approximately 1:6000 live births in our country. Chronic infection with Pseudomonas aeruginosa (PA) is associated with higher morbidity and-mortality, and deterioration of lung function. Treatment of initial infection is important to prevent or delay chronic infection. The primary aim was to determine the effectiveness and freetime of PA in bronchial secretions after eradication treatment. The secondary objective was to determine changes in the weight and lung function.
  
  
  METHODS
  Prospective, observational study, of patients with cystic fibrosis (CF) and recent PA infection. After initial infection by PA patients received oral ciprofoxacin and nebulized colistin. We studied effectiveness of treatment to eradicate PA, and changes in the weight measured in Z score and in the respiratory functional tests, pre-infection, during, and after the eradication of PA.
  
  
  RESULTS
  We included 24 patients (11 male) with confirmed CF. Seven of them had two PA infections, and received 2 treatment courses. PA was eradicated in 24 (80.5%) out of 31 infections. The value of weight measured in Z score, and functional tests measures through the FVC and FEV1 decreased during the infection by PA, returning to the baseline after eradication. The free-time of PA during the follow-up to these patients was 23.75 (95% CI 14.38-32.86) months.
  
  
  CONCLUSIONS
  Treatment of initial infection by PA has a high degree of response. Weight and functional values improved after treatment.
authors.affiliation: Servicio de Neumonología, Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires. hildagiugno@yahoo.com
authors.forename: Hilda
authors.initials: H
authors.lastname: Giugno
authors.forename: Claudio
authors.initials: C
authors.lastname: Castaños
authors.forename: Alberto
authors.initials: A
authors.lastname: Lubatti
authors.forename: José Luis
authors.initials: JL
authors.lastname: Pinheiro
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández
authors.forename: Hebe
authors.initials: H
authors.lastname: González Pena
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology*; D011550:Pseudomonas aeruginosa; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents