title: Efficacy of an alpha-hydroxy acid (AHA)-based cream, even in monotherapy, in patients with mild-moderate acne.
abstract: OBJECTIVE
  The treatment of mild-moderate acne with topical drugs in association with appropriate cosmetics is currently the golden standard. The tolerability and efficacy of a cream formulated with a new mix of alpha-hydroxy acids (Hyseac AHA cream) in 248 patients with mild-moderate acne (comedonic, inflammatory, or mixed) have been investigated in a multicenter, non-randomized, open study by 10 dermatologists from different Italian areas during their routine practice. The medication with Hyseac AHA cream was prescribed at first consultation for 60 days, twice a day, either as a monotherapy (49.2% patients) or in association with a pharmacological treatment (50.2%).
  
  
  RESULTS
  The tolerability was good to excellent in 92.3% patients, without significant differences between patients using AHA cream in monotherapy (90.0%) or associated with concomitant pharmacological treatment (97.6%). The efficacy was overall high in 64.2% patients, again without significant differences related to concomitant pharmacological treatment or not (64.8% vs. 63.3%) and/or the acne clinical type (comedonic vs. inflammatory vs. mixed: 69.2% vs. 66.7% vs. 58%).
  
  
  CONCLUSIONS
  The results of this study, while confirming the high tolerability and efficacy of this AHA cream in the treatment of mild/moderate acne, reasonably suggest its possible use also in monotherapy. Furthermore, its use can be reasonably hypothesized as a maintenance treatment after specific pharmacological treatment even in more severe acne types.
authors.affiliation: Dermatologic Clinic, Napoli Federico II University, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Baldo
authors.forename: P
authors.initials: P
authors.lastname: Bezzola
authors.forename: S
authors.initials: S
authors.lastname: Curatolo
authors.forename: T
authors.initials: T
authors.lastname: Florio
authors.forename: G
authors.initials: G
authors.lastname: Lo Guzzo
authors.forename: M
authors.initials: M
authors.lastname: Lo Presti
authors.forename: G P
authors.initials: GP
authors.lastname: Sala
authors.forename: F
authors.initials: F
authors.lastname: Serra
authors.forename: E
authors.initials: E
authors.lastname: Tonin
authors.forename: M
authors.initials: M
authors.lastname: Pellicano
authors.forename: N
authors.initials: N
authors.lastname: Pimpinelli
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D006880:Hydroxy Acids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D006880:Hydroxy Acids