Recognition of single stranded and double stranded DNA/RNA sequences in aqueous medium by small bis-aromatic derivatives.
The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure - DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator - nucleobase conjugates.
Tumir
L-M
LM
Laboratory for Study of Interactions of Biomacromolecules, Division of Organic Chemistry and Biochemistry, Ruder Bosković Institute, P. O. Box 180, HR-10002 Zagreb, Croatia.
Piantanida
I
I
D000818:Animals; D001483:Base Sequence; D004277:DNA, Single-Stranded / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000378:metabolism*; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000235:genetics* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry*
D004277:DNA, Single-Stranded; D006841:Hydrocarbons, Aromatic; D007364:Intercalating Agents; D012330:RNA, Double-Stranded; D014867:Water