Pinostrobin from Cajanus cajan (L.) Millsp. inhibits sodium channel-activated depolarization of mouse brain synaptoneurosomes.
This investigation focuses on the in vitro neuroactive properties of pinostrobin, a substituted flavanone from Cajanus cajan (L.) Millsp. of the Fabaceae family. We demonstrate that pinostrobin inhibits voltage-gated sodium channels of mammalian brain (IC(50)=23 µM) based on the ability of this substance to suppress the depolarizing effects of the sodium channel-selective activator veratridine in a synaptoneurosomal preparation from mouse brain. The resting membrane potential of synaptoneurosomes was unaffected by pinostrobin. The pharmacological profile of pinostrobin resembles that of depressant drugs that block sodium channels.
Nicholson
Russell A
RA
Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada. nicholso@sfu.ca
David
Laurence S
LS
Pan
Rui Le
RL
Liu
Xin Min
XM
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D036561:Cajanus / Q000737:chemistry*; D044950:Flavanones / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009465:Neuromuscular Agents / Q000494:pharmacology; D018515:Plant Leaves; D026941:Sodium Channel Blockers / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects*; D013574:Synaptosomes / Q000187:drug effects / Q000502:physiology; D014701:Veratridine / Q000494:pharmacology
D044950:Flavanones; D009465:Neuromuscular Agents; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D014701:Veratridine; C411294:pinostrobin