title: MicroRNAs: a new paradigm on molecular urological oncology.
abstract: MicroRNAs (miRNA) are a class of naturally occurring, small, noncoding RNAs that function as specific repressors of protein-encoding genes, being pivotal regulators of development and cellular homeostasis. They have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in different cancer types. Deregulation of these so-called "cancerous" miRNAs can figure prominently in tumor initiation and progression. The Human miRNA profile is under development, and it is of concern that there is so little agreement on the miRNAs found in each of the studies. Bioinformatics progress and efficient delivery are essential to overcome barriers to miRNA use in clinical practice.
authors.affiliation: Urologic Oncology Division, School of Medical Sciences, University of Campinas, São Paulo, Brazil. reisleo@unicamp.br
authors.forename: Leonardo Oliveira
authors.initials: LO
authors.lastname: Reis
authors.forename: Tiago Campos
authors.initials: TC
authors.lastname: Pereira
authors.forename: Iscia
authors.initials: I
authors.lastname: Lopes-Cendes
authors.forename: Ubirajara
authors.initials: U
authors.lastname: Ferreira
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D035683:MicroRNAs; D011379:Prognosis; D022661:RNA, Untranslated / Q000008:administration & dosage; D014571:Urologic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D014572:Urology / Q000379:methods
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated