The potential economic value of a Staphylococcus aureus vaccine for neonates.
The continuing morbidity and mortality associated with Staphylococcus aureus (S. aureus) infections, especially methicillin-resistant S. aureus (MRSA) infections, have motivated calls to make S. aureus vaccine development a research priority. We developed a decision analytic computer simulation model to determine the potential economic impact of a S. aureus vaccine for neonates. Our results suggest that a S. aureus vaccine for the neonatal population would be strongly cost-effective (and in many situations dominant) over a wide range of vaccine efficacies (down to 10%) for vaccine costs (<or=$500), and S. aureus attack rates (>or=1%).
Lee
Bruce Y
BY
Applied Modeling, Public Health Computational and Operations Research (PHICOR), Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu
Ufberg
Paul J
PJ
Bailey
Rachel R
RR
Wiringa
Ann E
AE
Smith
Kenneth J
KJ
Nowalk
Andrew J
AJ
Higgins
Conor
C
Wateska
Angela R
AR
Muder
Robert R
RR
D003198:Computer Simulation; D003362:Cost-Benefit Analysis; D006801:Humans; D007231:Infant, Newborn; D055624:Methicillin-Resistant Staphylococcus aureus / Q000276:immunology; D018803:Models, Economic; D013203:Staphylococcal Infections / Q000191:economics / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000191:economics*
D013209:Staphylococcal Vaccines
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