Glucosamine hydrochloride functionalized tetraphenylethylene: a novel fluorescent probe for alkaline phosphatase based on the aggregation-induced emission.
Grafting of glucosamine hydrochloride moieties to tetraphenylethylene (TPE) motif furnished a novel cationic water-soluble tetraphenylethylene derivative (GH-TPE). With aggregation-induced emission properties, GH-TPE was used for fluorometric detection to alkaline phosphatase through enzyme-triggered de-aggregation of the ensemble of GH-TPE and substrate.
Chen
Qi
Q
National Center for Nanoscience and Technology, Beijing 100190, China.
Bian
Ning
N
Cao
Chun
C
Qiu
Xi-Long
XL
Qi
Ai-Di
AD
Han
Bao-Hang
BH
D000469:Alkaline Phosphatase / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005470:Fluorometry / Q000379:methods*; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D005456:Fluorescent Dyes; D013267:Stilbenes; D014230:Triazoles; D000469:Alkaline Phosphatase; D005944:Glucosamine