In vivo micron-scale arthroscopic imaging of human knee osteoarthritis with optical coherence tomography: comparison with magnetic resonance imaging and arthroscopy.
Current treatments for osteoarthritis are pain relief and total joint arthroplasty. There is a clinical need for early osteoarthritis diagnostic methods for potential preventive interventions. The resolution achieved with radiography, magnetic resonance imaging (MRI), and arthroscopy is too limited for the assessment of early disease. The high resolution, small fiber-optic probes, and real-time imaging of optical coherence tomography (OCT) makes this method ideal for assessing articular cartilage. In this article, we describe in vivo human arthroscopic OCT with qualitative baseline comparisons made with MRI and arthroscopy. Two-year MRI follow-ups are under way to quantitatively compare OCT with MRI and to assess the long-term outcomes of changes noted in the OCT images.
Zheng
Kathy
K
Center for Optical Coherence Tomography and Optical Physics, Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Martin
Scott D
SD
Rashidifard
Christopher H
CH
Liu
Bin
B
Brezinski
Mark E
ME
D000328:Adult; D001182:Arthroscopy / Q000379:methods*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000473:pathology; D018579:Patient Selection; D011859:Radiography; D041623:Tomography, Optical Coherence / Q000379:methods*
Arthritis Rheum. 2007 May;56(5):1378-83
17469094
Appl Opt. 2006 Jun 20;45(18):4464-79
16778957
Anal Bioanal Chem. 2003 Nov;377(6):1003-6
14564447
IEEE Trans Med Imaging. 2005 Feb;24(2):155-9
15707241
J Rheumatol. 1999 Mar;26(3):627-35
10090174
Arthritis Res Ther. 2005;7(2):R318-23
15743479
Science. 1997 Jun 27;276(5321):2037-9
9197265
Rheum Dis Clin North Am. 2008 Aug;34(3):515-29
18687270
Br Med Bull. 2007;84:5-23
17785279
Radiol Clin North Am. 2002 Sep;40(5):1081-94
12462469
J Rheumatol. 2001 Jun;28(6):1311-8
11409125