title: Ovarian stimulation during the luteal phase for fertility preservation of cancer patients: case reports and review of the literature.
abstract: OBJECTIVE
  To report the case of a patient with a diagnosis of infiltrative ductal carcinoma of the breast (case 1) and of a patient with Hodgkin's lymphoma (case 2), both submitted to ovarian stimulation during the luteal phase of the menstrual cycle in order to cryopreserve embryos and oocytes, respectively, in view of the need to start chemotherapy within a maximum of three weeks.
  
  
  METHODS
  Case reports.
  
  
  RESULTS
  Both patients were submitted to ovarian stimulation with recombinant follicle stimulating hormone together with pituitary blockade with a GnRH antagonist during the luteal phase of the cycle. Oocyte retrieval was performed nine days after the beginning of ovarian stimulation, with 12 mature oocytes being obtained in both cases. In case 1, all mature oocytes were submitted to ICSI, with fertilization and cleavage rates of 83.3% and 70%, respectively, and with the formation of seven good quality embryos. In case 2, all of mature oocytes were cryopreserved.
  
  
  CONCLUSIONS
  These cases demonstrate that it is possible to obtain mature oocytes when ovarian stimulation is started in the luteal phase in situations in which there is not sufficient time for conventional stimulation.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital, Faculty of Medicine of Ribeirão Preto, USP, Monte Alegre, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Giuliano M
authors.initials: GM
authors.lastname: Bedoschi
authors.forename: Felipe Oliveira
authors.initials: FO
authors.lastname: de Albuquerque
authors.forename: Rui Alberto
authors.initials: RA
authors.lastname: Ferriani
authors.forename: Paula Andrea
authors.initials: PA
authors.lastname: Navarro
mesh_terms: D000328:Adult; D001943:Breast Neoplasms; D044584:Carcinoma, Ductal; D015925:Cryopreservation; D004622:Embryo, Mammalian; D005260:Female; D005298:Fertility; D006689:Hodgkin Disease; D006801:Humans; D008183:Luteal Phase; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods*
references.citation: Fertil Steril. 1990 Oct;54(4):638-42
references.pmid: 2209884
references.citation: Fertil Steril. 2009 Oct;92(4):1360-1365
references.pmid: 18930226
references.citation: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references.pmid: 19474385
references.citation: Hum Reprod. 2000 Jan;15(1):165-70
references.pmid: 10611207
references.citation: Fertil Steril. 2005 Apr;83(4):897-901
references.pmid: 15820797
references.citation: Biol Reprod. 2003 Sep;69(3):1023-31
references.pmid: 12748128
references.citation: Fertil Steril. 2008 Jun;89(6):1657-64
references.pmid: 17889865
references.citation: Hum Reprod Update. 2004 May-Jun;10(3):251-66
references.pmid: 15140872
references.citation: J Clin Oncol. 2006 Jun 20;24(18):2917-31
references.pmid: 16651642
references.citation: Fertil Steril. 2010 Feb;93(2):391-6
references.pmid: 19439285
references.citation: Eur J Cancer. 2007 Jul;43(11):1646-53
references.pmid: 17512721
references.citation: J Clin Invest. 1975 Apr;55(4):699-706
references.pmid: 1120778
references.citation: Hum Reprod. 1999 Oct;14(10):2665-8
references.pmid: 10528005
references.citation: Rheumatology (Oxford). 2008 Oct;47(10):1506-9
references.pmid: 18660508
references.citation: Curr Opin Obstet Gynecol. 2005 Jun;17(3):299-308
references.pmid: 15870565
references.citation: Fertil Steril. 1982 Sep;38(3):281-300
references.pmid: 6811331
references.citation: J Clin Endocrinol Metab. 1983 May;56(5):1022-31
references.pmid: 6403567
references.citation: Lancet. 2004 Dec 11-17;364(9451):2091-2; author reply 2092-3
references.pmid: 15589298