[Research progress in aldose reductase].
Aldose reductase is a member of aldehyde-keto reductase superfamily widely existing in the kidney, adrenal gland, lens, retina, nerve, heart, placenta, brain, skeletal muscle, testis, blood vessels, lung, liver, et al. It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. It is involved in many oxidative stress diseases, cell signal transduction and cell proliferation process as well as diabetes complications. In recent years, some progress has been made in research of the activity and gene regulation of aldose reductase and the relation with many common diseases.
Gu
Juan
J
Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
Yan
Jin
J
Wu
Weihua
W
Huang
Qi
Q
Ouyang
Dongsheng
D
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D000818:Animals; D049109:Cell Proliferation; D048909:Diabetes Complications / Q000188:drug therapy / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress; D012236:Rhodanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D015398:Signal Transduction; D053778:Thiazolidines / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D053778:Thiazolidines; C038131:epalrestat; D012236:Rhodanine; D000449:Aldehyde Reductase