title: Pregnancy during TNFalpha antagonist therapy: beware the rifampin-oral contraceptive interaction. Report of two cases.
abstract: We report two cases of pregnancy in patients taking TNFalpha antagonists for chronic inflammatory joint disease. A factor in both pregnancies was the use of rifampin concomitantly with a combined oral contraceptive. Both patients were taking rifampin and isoniazid for tuberculosis prophylaxis in compliance with French recommendations for patients with positive intradermal tuberculin tests who are scheduled to receive biotherapeutic agents.
authors.affiliation: Service de rhumatologie, hôpital Roger-Salengro, CHRU de Lille, université de Lille-2, rue Emile-Laine, 59037 Lille cedex, France. c-wibaux@chru-lille.fr
authors.forename: Cécile
authors.initials: C
authors.lastname: Wibaux
authors.forename: Irina
authors.initials: I
authors.lastname: Andrei
authors.forename: Julien
authors.initials: J
authors.lastname: Paccou
authors.forename: Peggy
authors.initials: P
authors.lastname: Philippe
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Biver
authors.forename: Bernard
authors.initials: B
authors.lastname: Duquesnoy
authors.forename: René Marc
authors.initials: RM
authors.lastname: Flipo
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000009:adverse effects*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007538:Isoniazid / Q000009:adverse effects; D011247:Pregnancy; D012293:Rifampin / Q000009:adverse effects*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy* / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D000995:Antitubercular Agents; D003276:Contraceptives, Oral; D014409:Tumor Necrosis Factor-alpha; D007538:Isoniazid; D012293:Rifampin