title: Polymorphisms in the GNB3 and ADD1 genes and blood pressure in a Chinese population.
abstract: A large proportion of the phenotypic variation in blood pressure (BP) appears to be inherited as a polygenic trait. This study examined the association between 12 single nucleotide polymorphisms (SNPs) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) and adducin 1 alpha (ADD1) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP. A total of 3,142 individuals from 636 families were recruited from rural north China, and 2,746 met the eligibility criteria for analysis. BP measurements were obtained using a random-zero sphygmomanometer. Genetic variants were determined using SNPlex assays on an automated DNA Sequencer. A mixed linear model was used to estimate the association between each SNP and BP level. After Bonferroni correction, marker rs4963516 of the GNB3 gene remained significantly associated with DBP (corrected P values = 0.006, 0.007 and 0.002 for co-dominant, additive, and recessive models, respectively) and MAP (corrected P values = 0.02, 0.049, and 0.005, respectively). Compared to carriers of the major A allele, CC homozygotes had higher mean DBP (75.81 +/- 0.62 vs. 73.46 +/- 0.25 mmHg, P = 0.0002) and MAP (91.87 +/- 0.68 vs. 89.42 +/- 0.28 mmHg, P = 0.0004) after adjusting for covariates of age, gender, BMI, study site, and room temperature during BP measurement. In summary, these data support a role for the GNB3 gene in BP regulation in the Chinese population. Future studies aimed at replicating these novel findings are warranted.
authors.affiliation: Division of Population Genetics, Department of Evidence Based Medicine, Cardiovascular Institute, Fu Wai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing, 100037, China.
authors.forename: Shufeng
authors.initials: S
authors.lastname: Chen
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Xiangfeng
authors.initials: X
authors.lastname: Lu
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Cashell E
authors.initials: CE
authors.lastname: Jaquish
authors.forename: Dabeeru C
authors.initials: DC
authors.lastname: Rao
authors.forename: James E
authors.initials: JE
authors.lastname: Hixson
authors.forename: Tanika N
authors.initials: TN
authors.lastname: Kelly
authors.forename: Liping
authors.initials: L
authors.lastname: Hou
authors.forename: Laiyuan
authors.initials: L
authors.lastname: Wang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Huang
authors.forename: Chung-Shiuan
authors.initials: CS
authors.lastname: Chen
authors.forename: Treva K
authors.initials: TK
authors.lastname: Rice
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
mesh_terms: D000483:Alleles; D001158:Arteries; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics* / Q000494:pharmacology; D002681:China; D005260:Female; D020962:Heterotrimeric GTP-Binding Proteins; D006801:Humans; D007022:Hypotension / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D020962:Heterotrimeric GTP-Binding Proteins; D000099291:Adducins; C454420:G-protein beta3 subunit
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