title: [Intratympanic drug delivery for the treatment of inner ear diseases].
abstract: BACKGROUND
  Intratympanic drug delivery for labyrinth diseases is a non-aggressive outpatient procedure where drugs reach high concentrations in the cochlea and minimum systemic diffusion. The aim of this review is to update the delivery techniques and report on the results obtained with different substances in cochleovestibular disorders. New perspectives in drug development and gene therapy are discussed.
  
  
  METHODS
  We have analyzed the literature published to date using the MEDLINE and EMBASE databases. The categories chosen for the review where the delivery techniques, the results using corticosteroids and aminoglucosides (gentamicin) and isolated papers related with new drugs or pathways to introduce the substance in the inner ear.
  
  
  RESULTS
  Intratympanic steroid therapy has been shown to be effective for cochleovestibular symptoms after failure of systemic steroids for sudden deafness and for control of Ménière's disease. Intratympanic gentamicin using a titration method showed vertigo control in 80% of the patients with a 0-25% risk of hearing impairment in Ménière's disease.
  
  
  CONCLUSIONS
  Intratympanic delivery is an effective procedure for the control of cochleovestibular disorders such as sudden deafness and Ménière's disease. Future perspectives could increase the indications for steroid and gentamicin treatment and open the door to new drugs and gene therapy.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario Fundación Alcorcón, Madrid, España. cherraizp@seorl.net
authors.forename: Carlos
authors.initials: C
authors.lastname: Herraiz
authors.forename: José
authors.initials: J
authors.lastname: Miguel Aparicio
authors.forename: Guillermo
authors.initials: G
authors.lastname: Plaza
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy*; D014432:Tympanic Membrane
chemical_list: D000305:Adrenal Cortex Hormones; D005839:Gentamicins