title: Respiratory muscle dysfunction in congestive heart failure--the role of pulmonary hypertension.
abstract: BACKGROUND
  Inspiratory muscle weakness has been described in patients with congestive heart failure (CHF), and only recently in patients with idiopathic pulmonary arterial hypertension. However, the relationship between pulmonary hemodynamics and respiratory muscle function has not been investigated in patients with CHF.
  
  
  RESULTS
  In two tertial referral centers for CHF patients, 532 consecutive CHF patients (159 female, age 59 ± 12 years, NYHA I-IV) were studied by right heart catheterization, maximal inspiratory mouth occlusion pressure (Pi(max)) and pressure 0.1s after beginning of inspiration during tidal breathing at rest (P(0.1)). There was a significant correlation between Pi(max) and mean pulmonary artery pressure (PAPm) (r=-0.65, p=0.0023), mean pulmonary capillary wedge pressure (PCWPm) (r=-0.56; p=0.0018), PVR (r=-0.73; p=0.0031), and cardiac output (r=0.51; p=0.0022). Moreover, the ratio P(0.1)/Pi(max) showed a linear correlation with PAPm (r=0.54; p=0.0019), and with TPG (r=0.64; p=0.0014) respectively. Vital capacity was reduced in relation to increased PAPm (r=-0.54; p=0.0029). Pi(max) and P(0.1)/Pi(max) were independent from VC.
  
  
  CONCLUSIONS
  This study provides the first evidence of a close relation between inspiratory muscle dysfunction, increased ventilatory drive and pulmonary hypertension in a large patient cohort with CHF. Pi(max) and P(0.1) can easily be measured in clinical routine and might become an additional parameter for the non-invasive monitoring of the hemodynamic severity of disease.
authors.affiliation: Department of Cardiology, Angiology, and Respiratory Medicine, Medical Center of the University Heidelberg, Heidelberg, Germany.
authors.forename: Arthur
authors.initials: A
authors.lastname: Filusch
authors.forename: Ralf
authors.initials: R
authors.lastname: Ewert
authors.forename: Maike
authors.initials: M
authors.lastname: Altesellmeier
authors.forename: Christian
authors.initials: C
authors.lastname: Zugck
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Mathias M
authors.initials: MM
authors.lastname: Borst
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
authors.forename: F Joachim
authors.initials: FJ
authors.lastname: Meyer
mesh_terms: D000368:Aged; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology*; D001239:Inhalation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000150:complications / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000503:physiopathology*