title: Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using omega-transaminases.
abstract: A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various omega-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine.
authors.affiliation: Department of Chemistry, Organic & Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Fuchs
authors.forename: Dominik
authors.initials: D
authors.lastname: Koszelewski
authors.forename: Katharina
authors.initials: K
authors.lastname: Tauber
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
authors.forename: Kurt
authors.initials: K
authors.lastname: Faber
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D001419:Bacteria / Q000201:enzymology*; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D048448:Phenylcarbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D000068836:Rivastigmine; D013237:Stereoisomerism; D000637:Transaminases / Q000378:metabolism*
chemical_list: D000098:Acetophenones; D018696:Neuroprotective Agents; D048448:Phenylcarbamates; D000637:Transaminases; D000068836:Rivastigmine; C038699:acetophenone