Novel neurohormonal insights with therapeutic potential in chronic heart failure.
Despite considerable therapeutic advances over recent years, chronic heart failure remains associated with significant morbidity and mortality. Further improvements in the treatment of this syndrome are therefore needed and this will require advances in the understanding of its underlying pathophysiology. This article reviews the literature regarding recently identified neurohormonal pathways that are declaring themselves as potential therapeutic targets in chronic heart failure.
Dalzell
Jonathan R
JR
Scottish Advanced Heart Failure Unit, Golden Jubilee National Hospital, Glasgow, G81 4HX, UK. j.dalzell@nhs.net
Jackson
Colette E
CE
D000803:Angiotensin I / Q000627:therapeutic use; D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002320:Cardiovascular Physiological Phenomena; D006333:Heart Failure / Q000097:blood / Q000628:therapy*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology / Q000627:therapeutic use; D009206:Myocardium / Q000378:metabolism; D010446:Peptide Fragments / Q000627:therapeutic use; D007703:Peptidyl-Dipeptidase A / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D012065:Relaxin / Q000502:physiology / Q000627:therapeutic use; D012083:Renin / Q000097:blood / Q000378:metabolism; D054832:Urocortins / Q000097:blood / Q000502:physiology / Q000627:therapeutic use; D000093342:Prorenin Receptor
D000959:Antihypertensive Agents; D036341:Intercellular Signaling Peptides and Proteins; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D054832:Urocortins; D012065:Relaxin; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2; D012083:Renin; C118790:angiotensin I (1-7); D000093342:Prorenin Receptor