Glucagonoma syndrome and necrolytic migratory erythema.
The glucagonoma syndrome is a rare disorder, characterized by necrolytic migratory erythema, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia in association with a glucagon-secreting alpha-cell tumor of the pancreas. We present a 67-year-old diabetic patient with extensive cutaneous lesions, weight loss, and poor glycemic control. The clinical investigation revealed a pancreatic glucagonoma with resolution of the cutaneous and systemic features after surgical removal. The dermatologic and endocrine approach to this syndrome is discussed here. Early recognition and treatment may prevent metastatic disease and ensure its cure with resolution of the cutaneous and catabolic manifestations.
Lobo
Inês
I
Department of Dermatology, Hospital Geral de Santo António, Centro Hosptalar do Porto, Portugal. inesmlobo@hotmail.com
Carvalho
André
A
Amaral
Cláudia
C
Machado
Susana
S
Carvalho
Rui
R
D000368:Aged; D001706:Biopsy; D004890:Erythema / Q000209:etiology* / Q000473:pathology*; D005934:Glucagon / Q000097:blood; D005935:Glucagonoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008297:Male; D009336:Necrosis; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D012867:Skin / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D005934:Glucagon