Effectiveness of rotavirus vaccines for prevention of rotavirus gastroenteritis-associated hospitalizations in Israel: a case-control study.
The association between rotavirus gastroenteritis (RVGE)-associated hospitalization and rotavirus vaccine receipt was examined, and vaccine effectiveness was estimated in a case-control study conducted between 11/2007 and 12/2009 among Israeli children age eligible for rotavirus vaccination. Cases (n=111) were hospitalized children with diarrhea testing positive for rotavirus by immunochromatography. Controls (n=216) were hospitalized children with diarrhea testing negative for rotavirus. Among controls 36 (16.7%) children were vaccinated against rotavirus compared with two children (1.8%) among cases (p < 0.001). Rotavirus immunization was associated with lower risk of RVGE-associated hospitalization; adjusted OR 0.106 (95% CI 0.024, 0.481), yielding a vaccine effectiveness of 89.4% (95% CI 51.9%, 97.6%) in preventing hospitalization. These data demonstrate high effectiveness of rotavirus vaccines in a high income country.
Muhsen
Khitam
K
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shulman
Lester
L
Kasem
Eias
E
Rubinstein
Uri
U
Shachter
Jacob
J
Kremer
Adi
A
Goren
Sophy
S
Zilberstein
Ilana
I
Chodick
Gabby
G
Ephros
Moshe
M
Cohen
Dani
D
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005759:Gastroenteritis / Q000517:prevention & control* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007557:Israel; D008297:Male; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage*
D022243:Rotavirus Vaccines