[Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates].
KRAB-containing zinc-finger proteins (KRAB-ZFPs) first arose in the tetrapod vertebrates, and evolved quickly. Till Homo sapiens, they have become the largest family of transcription factors. Despite the molecular mechanism of transcription regulation by KRAB-ZFPs has been clarified in some degree, the higher-vertebrate-specific biological functions of the KRAB-ZFP family are still largely unknown. This review focused on the important regulatory functions of the KRAB-ZFP in embryonic development and tumorgenesis, which will benefit to the comprehensive understanding of biological roles of KRAB-ZFP in different physiological and pathological states. All of the systematic information will facilitate the further theoretical and applied studies of KRAB-ZFPs.
Ma
Zhan-Fu
ZF
College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100022, China. zfma@emails.bjut.edu.cn
Yang
Dong
D
He
Fu-Chu
FC
Jiang
Ying
Y
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D012097:Repressor Proteins / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D014714:Vertebrates / Q000196:embryology / Q000235:genetics*
D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53; C422407:ZNF350 protein, human