title: Condition, innate immunity and disease mortality of inbred crows.
abstract: Cooperatively breeding American crows (Corvus brachyrhynchos) suffer a severe disease-mediated survival cost from inbreeding, but the proximate mechanisms linking inbreeding to disease are unknown. Here, we examine indices of nestling body condition and innate immunocompetence in relationship to inbreeding and disease mortality. Using an estimate of microsatellite heterozygosity that predicts inbreeding in this population, we show that inbred crows were in relatively poor condition as nestlings, and that body condition index measured in the first 2-33 days after hatching, in addition to inbreeding index, predicted disease probability in the first 34 months of life. Inbred nestlings also mounted a weaker response along one axis of innate immunity: the proportion of bacteria killed in a microbiocidal assay increased as heterozygosity index increased. Relatively poor body condition and low innate immunocompetence are two mechanisms that might predispose inbred crows to ultimate disease mortality. A better understanding of condition-mediated inbreeding depression can guide efforts to minimize disease costs of inbreeding in small populations.
authors.affiliation: Fuller Evolutionary Biology Program, Cornell Laboratory of Ornithology, , 159 Sapsucker Woods Road, Ithaca, NY 14850, USA. at256@cornell.edu
authors.forename: Andrea K
authors.initials: AK
authors.lastname: Townsend
authors.forename: Anne B
authors.initials: AB
authors.lastname: Clark
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: McGowan
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Buckles
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000276:immunology* / Q000382:microbiology / Q000401:mortality*; D046368:Crows / Q000235:genetics / Q000382:microbiology / Q000502:physiology*; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology / Q000401:mortality / Q000662:veterinary*; D005260:Female; D007113:Immunity, Innate; D007121:Immunocompetence; D007178:Inbreeding; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009425:Nesting Behavior; D011157:Population Dynamics; D012726:Sexual Behavior, Animal
references.citation: Anim Behav. 2009 Feb 1;77(2):503-512
references.pmid: 20126287
references.citation: Trends Ecol Evol. 1988 Oct;3(10):254-9
references.pmid: 21227241
references.citation: Proc Biol Sci. 2003 Feb 7;270(1512):241-8
references.pmid: 12614572
references.citation: J Vet Diagn Invest. 2010 Mar;22(2):289-95
references.pmid: 20224095
references.citation: Proc Biol Sci. 2001 Oct 7;268(1480):2021-7
references.pmid: 11571049
references.citation: Proc Biol Sci. 2009 Jun 7;276(1664):2057-64
references.pmid: 19324784
references.citation: Evolution. 2007 Jun;61(6):1391-402
references.pmid: 17542848
references.citation: J Evol Biol. 2008 May;21(3):834-41
references.pmid: 18312317
references.citation: J Evol Biol. 2008 May;21(3):873-8
references.pmid: 18298497
references.citation: J Hered. 2005 Mar-Apr;96(2):85-8
references.pmid: 15618305
references.citation: Biol Lett. 2005 Sep 22;1(3):326-9
references.pmid: 17148199
references.citation: Proc Biol Sci. 2007 Mar 7;274(1610):697-706
references.pmid: 17254994
references.citation: Heredity (Edinb). 2008 Jun;100(6):587-93
references.pmid: 18398424
references.citation: Ecol Appl. 2009 Jun;19(4):829-39
references.pmid: 19544727
references.citation: Proc Biol Sci. 2008 Aug 7;275(1644):1753-9
references.pmid: 18448414
references.citation: Proc Biol Sci. 2004 Feb 7;271 Suppl 3:S110-3
references.pmid: 15101435
references.citation: Evolution. 1999 Aug;53(4):1259-1267
references.pmid: 28565537
references.citation: Mol Ecol. 2004 Oct;13(10):3021-31
references.pmid: 15367117
references.citation: Am Nat. 2010 Jan;175(1):E1-9
references.pmid: 19929635
references.citation: Parasitology. 2007 Jan;134(Pt 1):23-31
references.pmid: 16948876
references.citation: Science. 1994 Jan 28;263(5146):485-6
references.pmid: 8290956
references.citation: Dev Comp Immunol. 2005;29(3):275-86
references.pmid: 15572075
references.citation: Immunol Today. 2000 Dec;21(12):624-30
references.pmid: 11114423
references.citation: Proc Biol Sci. 2006 Apr 7;273(1588):797-804
references.pmid: 16618672
references.citation: Naturwissenschaften. 2009 Oct;96(10):1193-202
references.pmid: 19609498
references.citation: Proc Biol Sci. 2006 Oct 22;273(1601):2633-40
references.pmid: 17002949
references.citation: Proc Biol Sci. 2008 Mar 22;275(1635):703-11
references.pmid: 18211876
references.citation: Heredity (Edinb). 2004 Sep;93(3):255-65
references.pmid: 15254488
references.citation: Dev Comp Immunol. 2007;31(2):188-201
references.pmid: 16870251
references.citation: Annu Rev Nutr. 2001;21:297-321
references.pmid: 11375439
references.citation: Poult Sci. 1998 Aug;77(8):1119-25
references.pmid: 9706075
references.citation: Nature. 2003 Mar 6;422(6927):35
references.pmid: 12621424
references.citation: Epidemiol Infect. 2009 Sep;137(9):1295-301
references.pmid: 19144246
references.citation: Evolution. 2007 Sep;61(9):2268-73
references.pmid: 17767596
references.citation: Poult Sci. 1981 Nov;60(11):2494-2500
references.pmid: 6799951