title: Natural history of infections with high-risk HPV in Chinese women with abnormal cervical cytology findings at baseline.
abstract: OBJECTIVE
  To clarify the natural history of disease in Chinese women with benign cytologic observation and positive for high-risk human papillomavirus (HR-HPV).
  
  
  METHODS
  From September 1, 2004, to June 30, 2008, this prospective study followed up 893 women positive for HR-HPV who also had benign cytologic findings at baseline.
  
  
  RESULTS
  After 3 to 57 months, the viral clearance rate was higher for patients younger than 30 years and for patients who had a low viral load at baseline than for those in their comparison groups. Conversely, the occurrence rate of cervical intraepithelial neoplasia (CIN) 2 or 3 was higher for patients with persistent HR-HPV infection, those who had CIN 1 at baseline, and those whose the second viral load was increased.
  
  
  CONCLUSIONS
  Age, viral load, and presence of CIN 1 at the first evaluation were the main factors affecting the natural history of HR-HPV infection in women with benign baseline cytologic findings. The result(s) of the second HR-HPV testing were independent indicators of histologic progression.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Guo
authors.forename: Ke
authors.initials: K
authors.lastname: You
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Zhao
authors.forename: Cong-rong
authors.initials: CR
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Geng
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000473:pathology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology*; D019562:Viral Load; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000821:virology*