Relationship between serum uric acid levels with chronic kidney disease in a Southeast Asian population.
OBJECTIVE
Elevated serum uric level has been suggested as a risk factor for chronic kidney disease (CKD). The relationship between serum uric acid level, and CKD in a Southeast Asian population was examined.


METHODS
In a cross-sectional study, authors surveyed 5618 subjects, but 5546 participants were included. The glomerular filtration rate (GFR) values were calculated by the Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as a GFR of less than 60 mL/min per 1.73 m(2). Multivariate binary logistic regression was used to determine the association between serum uric acid level and CKD.


RESULTS
The prevalence of CKD in serum uric acid quartiles: first quartile, 5.3 mg/dL or less; second quartile, 5.4-6.4 mg/dL; third quartile, 6.5-7.6 mg/dL; and fourth quartile, 7.7 mg/dL or more were 1.8%, 3.6%, 5.5% and 11.9%, respectively (P < 0.001). The mean values of estimated GFR in participants with CKD and without CKD were 53.44 +/- 7.72 and 81.26 +/- 12.48 mL/min per 1.73 m(2) respectively. In the entire participants, there were 6.76% with hypertension and 2.64% with diabetes as a comorbid disease. Compared with serum uric acid first quartile, the multivariate-adjusted odds for CKD of the fourth, third and second quartile were 10.94 (95% confidence interval (CI), 6.62-16.08), 4.17 (95% CI, 2.51-6.92) and 2.38 (95% CI, 1.43-3.95), respectively.


CONCLUSIONS
High serum uric acid level was independently associated with increased prevalence of CKD in the Southeast Asian population. Detection and treatment of hyperuricaemia should be attended as a strategy to prevent CKD.
Satirapoj
Bancha
B
Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand. satirapoj@yahoo.com
Supasyndh
Ouppatham
O
Chaiprasert
Amnart
A
Ruangkanchanasetr
Prajej
P
Kanjanakul
Inseey
I
Phulsuksombuti
Duangporn
D
Utainam
Darunee
D
Choovichian
Panbuppa
P
D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006306:Health Surveys; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000150:complications / Q000208:ethnology / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid