Does the progeny of premature ischemic stroke sufferers need intensive interest of physicians oriented toward primary prevention? A pilot study.
BACKGROUND
Few studies focus on the progeny of stroke patients with respect to the occurrence of other potential risk factors.


METHODS
The study group covered 60 males and 62 females whose parents had suffered premature ischemic stroke (PIS); the control group comprised of 41 males and 47 females whose parents had no history of premature vascular event (mean age: 28.4 and 27.1 years, respectively). Examination of both the groups consisted of evaluation of their diet, measurement of arterial blood pressure and body mass index (BMI). Moreover, blood test was carried out and concentration of biochemical stroke risk factors was determined.


RESULTS
The adult progeny of parents with a history of PIS followed a deficient, unbalanced, and nonvaried diet. Their average blood pressure and BMI reached higher values, compared with the results obtained in the control group (125.7±16.06 vs. 122.64±10.83 mmHg; 24.27±3.98 vs. 22.54±2.69 kg/m, respectively; P<0.05). The same applies to average concentrations of the triglycerides 1.22±0.76 vs. 1.06±0.54 mmol/l; total cholesterol (5.34±1.16 vs. 4.82±0.89 mmol/l), low-density lipoprotein-cholesterol (2.95±0.97 vs. 2.52±0.73 mmol/l), total homocysteine (11.22±4.22 vs. 10.18±2.45 μmol/l), and fibrinogen (2.91±0.68 vs. 2.78±0.6 g/l) (P<0.05).


CONCLUSIONS
Adult children of PIS sufferers show different stroke risk factor profiles than the control group. It may indicate a need for preventive activities for this group in the future. Family occurrence of stroke requires further detailed studies on a larger cohort of patients from risk group.
Mierzecki
Artur
A
Independent Laboratory of Family Physician Education, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. roklr@sci.pam.szczecin.pl
Kozłowska-Wojciechowska
Małgorzata
M
Bukowska
Hanna
H
Makarewicz-Wujec
Magdalena
M
Honczarenko
Krystyna
K
Chełstowski
Kornel
K
Jastrzębska
Maria
M
Masztalewicz
Marta
M
D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010375:Pedigree; D010641:Phenotype; D010865:Pilot Projects; D011044:Poland / Q000453:epidemiology; D011322:Primary Prevention; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D055815:Young Adult
D015415:Biomarkers; D008055:Lipids; D006710:Homocysteine; D005340:Fibrinogen