Modeling biopotential signals and current densities of multiple breast cancerous cells.
This study presents a model to simulate the electrophysiological activities of multiple Michigan Cancer Foundation-7 (MCF-7) cells, the most studied breast cancer cell line. The intercellular spacing of MCF-7 cells is estimated using the effective diffusion coefficient. Nonuniform finite-difference discretization is implemented to accommodate for the contrast in size between the intercellular spacing and the cell dimension. The model computes the amplitude and the spatiotemporal patterns of biopotentials and electric current densities at different cell division stages. The results show that the biopotentials increase proportionally to the number of cells, especially when all cells are in the hyperpolarization stage. Also, the results show significant electric current density in the intercellular gap between the cells.
Hassan
Ahmed M
AM
Department of Electrical Engineering, Universityof Arkansas, Fayetteville, AR 72701, USA. amhassan@uark.edu
El-Shenawee
Magda
M
D000465:Algorithms; D001943:Breast Neoplasms / Q000503:physiopathology*; D045744:Cell Line, Tumor; D002468:Cell Physiological Phenomena; D055724:Electrophysiological Phenomena; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D016217:Ultrasonography, Mammary