title: Photodynamic therapy for focal ablation of the prostate.
abstract: Although in early stages of clinical development, photodynamic therapy (PDT) shows promise in delivering focal treatment of both primary and post-radiotherapy prostate cancer. This article will review the mechanism of action of PDT, previous research using PDT for treating prostate cancer including the development of newer vascular-acting photosensitizers, and the potential advantages and disadvantages of PDT in delivering focal therapy.
authors.affiliation: Division of Surgery and Interventional Sciences, National Medical Laser Centre, University College London, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, UK. nim.arum@ucl.ac.uk
authors.forename: Nimalan
authors.initials: N
authors.lastname: Arumainayagam
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: Hashim U
authors.initials: HU
authors.lastname: Ahmed
authors.forename: M
authors.initials: M
authors.lastname: Emberton
mesh_terms: D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use; D008665:Metalloporphyrins / Q000627:therapeutic use; D010778:Photochemotherapy / Q000009:adverse effects; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D008652:Mesoporphyrins; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; C102825:motexafin lutetium; D017323:Dihematoporphyrin Ether; C072269:temoporfin
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