title: Macrophage colony-stimulating factor (M-CSF) in plasma and CSF of patients with mild cognitive impairment and Alzheimer's disease.
abstract: Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that activates microglial cells, involved in phagocytosis of amyloid-beta (Abeta) in the brain. In the present study, we found in 50 patients with Alzheimer's disease (AD) significantly increased M-CSF plasma levels compared to 22 patients with mild cognitive impairment (MCI) and 35 age-matched healthy controls. In contrast, MCI patients showed significantly decreased M-CSF levels in cerebrospinal fluid (CSF) compared to AD patients and 20 patients with other non-inflammatory neurological disease (NIND). Analyzing the impact of Beta-amyloid 1-42 (Abeta 1-42), tau protein and M-CSF for differentiation between the groups we found that M-CSF, but not Abeta 1-42 and tau-protein is a significant parameter for distinction between MCI and NIND patients with 68.8% sensitivity and 75.0% specificity. M-CSF CSF levels < or = 357.8 pg/ml yielded 73.7% sensitivity and 75.0% specificity for diagnosing MCI patients in comparison with control subjects. In conclusion, our data indicate that M-CSF in CSF could be a putative biomarker for MCI.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 24, D-72076 Tübingen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Laske
authors.forename: E
authors.initials: E
authors.lastname: Stransky
authors.forename: N
authors.initials: N
authors.lastname: Hoffmann
authors.forename: W
authors.initials: W
authors.lastname: Maetzler
authors.forename: G
authors.initials: G
authors.lastname: Straten
authors.forename: G W
authors.initials: GW
authors.lastname: Eschweiler
authors.forename: T
authors.initials: T
authors.lastname: Leyhe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D016173:Macrophage Colony-Stimulating Factor