Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling.
The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C-H/C-OH bond activations with direct C(sp(2))-C(sp) bond formation, which is in line with ideal synthesis using readily available materials.
Kang
Fu-An
FA
Johnson & Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA. fkang@its.jnj.com
Lanter
James C
JC
Cai
Chaozhong
C
Sui
Zhihua
Z
Murray
William V
WV
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
D000480:Alkynes; D006571:Heterocyclic Compounds; D009943:Organophosphorus Compounds; D010165:Palladium; D003300:Copper