title: Update on newer antihypertensive medicines and interventions.
abstract: The incidence and prevalence of systemic hypertension are reaching global epidemic proportions. Despite a diverse pharmacologic armamentarium of agents to treat high blood pressure, suboptimal control remains a significant problem in as many as 43% of patients and this rate has not significantly improved over the past 2 decades. There are a variety of factors contributing to this including patient nonadherence due to complex drug regimens and medication side effects, undertreatment, and treatment resistance. There, thus, remains a need to develop novel agents and approaches to antihypertensive therapy that facilitate attainment of optimal blood pressure levels. This monograph will review a number of new pharmacologic targets and interventions as well as a novel method of drug delivery to patients.
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. kwu@jhmi.edu
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Wu
authors.forename: Gary
authors.initials: G
authors.lastname: Gerstenblith
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D016503:Drug Delivery Systems; D004351:Drug Resistance; D065128:Endothelin Receptor Antagonists; D000072396:Endothelin-Converting Enzymes; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D010349:Patient Compliance; D011372:Progestins / Q000627:therapeutic use; D014612:Vaccines / Q000627:therapeutic use
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000959:Antihypertensive Agents; D065128:Endothelin Receptor Antagonists; D000451:Mineralocorticoid Receptor Antagonists; D011372:Progestins; D014612:Vaccines; D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; D000072396:Endothelin-Converting Enzymes