The type 2C protein phosphatase FgPtc1p of the plant fungal pathogen Fusarium graminearum is involved in lithium toxicity and virulence.
Type 2C protein phosphatases (PP2Cs) are monomeric protein serine/threonine phosphatases that play various roles in eukaryotic organisms. In this study, we characterized the PP2C encoded by FgPTC1 in Fusarium graminearum, the major causal agent of Fusarium head blight on wheat and barley. We found that deletion of FgPTC1 delays the mycelium growth of F. graminearum in response to lithium. Consistently, FgPTC1 complemented the function of ScPTC1 in lithium toxicity in Saccharomyces cerevisiae. Furthermore, we showed that deletion of FgPTC1 attenuated the virulence of F. graminearum on wheat. Therefore, FgPTC1 plays an important role in regulating the hyphal growth and virulence of F. graminearum.
Jiang
Linghuo
L
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China. linghuojiang2@yahoo.com.cn
Yang
Jingran
J
Fan
Feiyu
F
Zhang
Dajun
D
Wang
Xuli
X
D005670:Fusarium / Q000187:drug effects / Q000201:enzymology* / Q000472:pathogenicity*; D017353:Gene Deletion; D008094:Lithium / Q000633:toxicity*; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D016366:Open Reading Frames / Q000235:genetics; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D000071636:Protein Phosphatase 2C; D011993:Recombinant Fusion Proteins / Q000302:isolation & purification / Q000378:metabolism; D014908:Triticum / Q000187:drug effects / Q000382:microbiology; D014774:Virulence / Q000187:drug effects
D011993:Recombinant Fusion Proteins; D008094:Lithium; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C
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