Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction.
Oligobenzamide inhibitors of the p53-hDM2 protein-protein interaction are described.
Plante
Jeffrey P
JP
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK LS29JT.
Burnley
Thomas
T
Malkova
Barbora
B
Webb
Michael E
ME
Warriner
Stuart L
SL
Edwards
Thomas A
TA
Wilson
Andrew J
AJ
D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D051736:Proto-Oncogene Proteins c-mdm2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors* / Q000378:metabolism
D001549:Benzamides; D004791:Enzyme Inhibitors; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
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