Interhemispheric coupling between the posterior sylvian regions impacts successful auditory temporal order judgment.
Accurate perception of the temporal order of sensory events is a prerequisite in numerous functions ranging from language comprehension to motor coordination. We investigated the spatio-temporal brain dynamics of auditory temporal order judgment (aTOJ) using electrical neuroimaging analyses of auditory evoked potentials (AEPs) recorded while participants completed a near-threshold task requiring spatial discrimination of left-right and right-left sound sequences. AEPs to sound pairs modulated topographically as a function of aTOJ accuracy over the 39-77ms post-stimulus period, indicating the engagement of distinct configurations of brain networks during early auditory processing stages. Source estimations revealed that accurate and inaccurate performance were linked to bilateral posterior sylvian regions activity (PSR). However, activity within left, but not right, PSR predicted behavioral performance suggesting that left PSR activity during early encoding phases of pairs of auditory spatial stimuli appears critical for the perception of their order of occurrence. Correlation analyses of source estimations further revealed that activity between left and right PSR was significantly correlated in the inaccurate but not accurate condition, indicating that aTOJ accuracy depends on the functional decoupling between homotopic PSR areas. These results support a model of temporal order processing wherein behaviorally relevant temporal information--i.e. a temporal 'stamp'--is extracted within the early stages of cortical processes within left PSR but critically modulated by inputs from right PSR. We discuss our results with regard to current models of temporal of temporal order processing, namely gating and latency mechanisms.
Bernasconi
Fosco
F
Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, Lausanne, Switzerland.
Grivel
Jeremy
J
Murray
Micah M
MM
Spierer
Lucas
L
D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007600:Judgment / Q000502:physiology*; D008297:Male; D009483:Neuropsychological Tests; D011571:Psychoacoustics; D011597:Psychomotor Performance / Q000502:physiology; D013998:Time Perception / Q000502:physiology*; D055815:Young Adult