title: Male-only systemic lupus.
abstract: OBJECTIVE
  Systemic lupus erythematosus (SLE) is more common among women than men, a ratio of about 10 to 1. We undertook this study to describe familial male SLE within a large familial SLE cohort.
  
  
  METHODS
  SLE families (2 or more patients) were identified from the Lupus Multiplex Registry and Repository. Genomic DNA and blood samples were obtained using standard methods. Autoantibodies were determined by multiple methods. Medical records were abstracted for SLE clinical data. Fluorescent in situ hybridization (FISH) was performed with X and Y centromere-specific probes, and a probe specific for the Toll-like receptor 7 gene on the X chromosome.
  
  
  RESULTS
  Among 523 SLE families, we found 5 families in which all the SLE patients were male. FISH found no yaa gene equivalent in these families. SLE-unaffected primary female relatives from the 5 families with only-male SLE patients had a statistically increased rate of positive antinuclear antibodies compared to SLE-unaffected female relatives in other families. White men with SLE were 5 times more likely to have an offspring with SLE than White women with SLE, but there was no difference in this likelihood among Black men.
  
  
  CONCLUSIONS
  Because women in the all-male families had positive antinuclear antibodies, and men are more likely to have children with SLE, these data suggest genetic susceptibility factors that act only in men.
authors.affiliation: Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Rachna-aggarwal@omrf.ouhsc.edu.
authors.forename: Rachna
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Bahram
authors.initials: B
authors.lastname: Namjou
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
authors.forename: Anil
authors.initials: A
authors.lastname: D'Souza
authors.forename: Betty P
authors.initials: BP
authors.lastname: Tsao
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Bruner
authors.forename: Judith A
authors.initials: JA
authors.lastname: James
authors.forename: R Hal
authors.initials: RH
authors.lastname: Scofield
mesh_terms: D001741:Black or African American / Q000235:genetics; D000974:Antibodies, Antinuclear / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000235:genetics; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000235:genetics*; D008297:Male; D010375:Pedigree; D012042:Registries; D044465:White People / Q000235:genetics
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies
references.citation: Chin Med J (Engl). 2007 Dec 5;120(23):2124-8
references.pmid: 18167187
references.citation: J Gend Specif Med. 2000 Jul-Aug;3(5):29-32
references.pmid: 11253253
references.citation: N Engl J Med. 2008 Feb 28;358(9):900-9
references.pmid: 18204098
references.citation: J Immunol. 1969 Jan;102(1):117-22
references.pmid: 4179557
references.citation: Br J Haematol. 1990 Jan;74(1):1-9
references.pmid: 2178669
references.citation: Scand J Immunol. 2006 Sep;64(3):227-35
references.pmid: 16918691
references.citation: Arthritis Rheum. 1983 Jan;26(1):39-44
references.pmid: 6600612
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14869-74
references.pmid: 9843982
references.citation: Arthritis Rheum. 2002 Nov;46(11):2928-36
references.pmid: 12428234
references.citation: J Reprod Immunol. 2008 Jan;77(1):51-6
references.pmid: 17418423
references.citation: J Exp Med. 2008 May 12;205(5):1099-108
references.pmid: 18443225
references.citation: N Engl J Med. 1984 Jul 19;311(3):149-52
references.pmid: 6738600
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9970-5
references.pmid: 16777955
references.citation: Arthritis Rheum. 1992 Mar;35(3):311-8
references.pmid: 1536669
references.citation: Br Med J. 1957 Sep 28;2(5047):732-4
references.pmid: 13460368
references.citation: Science. 2006 Jun 16;312(5780):1669-72
references.pmid: 16709748
references.citation: Autoimmunity. 2007 Dec;40(8):550-9
references.pmid: 18075789
references.citation: Arthritis Rheum. 2007 Feb;56(2):622-30
references.pmid: 17265497
references.citation: J Med Genet. 1969 Sep;6(3):233-54
references.pmid: 5345095
references.citation: Lupus. 2005;14(12):938-46
references.pmid: 16425573
references.citation: J Immunol. 2004 Mar 1;172(5):2731-8
references.pmid: 14978070
references.citation: Adv Immunol. 2006;92:1-69
references.pmid: 17145301
references.citation: Clin Rheumatol. 1993 Dec;12(4):522-5
references.pmid: 8124916
references.citation: Autoimmun Rev. 2003 May;2(3):119-25
references.pmid: 12848952
references.citation: Lupus. 1995 Dec;4(6):425-37
references.pmid: 8749564
references.citation: Ann Rheum Dis. 1992 Sep;51(9):1050-2
references.pmid: 1417135
references.citation: Arthritis Rheum. 2007 Oct;56(10):3375-8
references.pmid: 17907191
references.citation: Lupus. 2006;15(2):61-4
references.pmid: 16539274
references.citation: Clin Rev Allergy Immunol. 2007 Apr;32(2):159-61
references.pmid: 17916986
references.citation: Diabetologia. 1995 Jun;38(6):715-9
references.pmid: 7672495
references.citation: Br Med Bull. 1961 Sep;17:251-4
references.pmid: 13691133
references.citation: Lupus. 2003;12(2):99-106
references.pmid: 12630753
references.citation: Singapore Med J. 1980 Dec;21(6):775-7
references.pmid: 7194512
references.citation: Arthritis Res Ther. 2007;9(3):210
references.pmid: 17509159
references.citation: J Rheumatol. 1990 Feb;17(2):220-4
references.pmid: 2319521
references.citation: Nat Genet. 2008 Feb;40(2):204-10
references.pmid: 18204446
references.citation: Isr Med Assoc J. 2008 Jan;10(1):3-7
references.pmid: 18300562
references.citation: Arthritis Rheum. 2002 Feb;46(2):428-35
references.pmid: 11840445
references.citation: Br J Rheumatol. 1994 Apr;33(4):339-42
references.pmid: 8156305
references.citation: Medicine (Baltimore). 1976 Jul;55(4):313-22
references.pmid: 781465
references.citation: Ann N Y Acad Sci. 2007 Aug;1109:1-8
references.pmid: 17785284
references.citation: Hum Genet. 2005 Dec;118(3-4):309-21
references.pmid: 16189706
references.citation: Arthritis Rheum. 1997 Sep;40(9):1725
references.pmid: 9324032
references.citation: Lupus. 1992 Oct;1(5):295-8
references.pmid: 1303221
references.citation: Arthritis Rheum. 1982 Nov;25(11):1271-7
references.pmid: 7138600
references.citation: Arthritis Rheum. 1973 Mar-Apr;16(2):221-4
references.pmid: 4716434
references.citation: J Rheumatol. 1999 Jul;26(7):1495-9
references.pmid: 10405936
references.citation: Am J Public Health. 2000 Sep;90(9):1463-6
references.pmid: 10983209
references.citation: J Exp Med. 1978 Nov 1;148(5):1198-215
references.pmid: 309911
references.citation: J Rheumatol. 2002 Aug;29(8):1674-7
references.pmid: 12180728
references.citation: Clin Immunol Immunopathol. 1994 Sep;72(3):335-41
references.pmid: 7914842
references.citation: Arthritis Rheum. 2003 Aug;48(8):2100-10
references.pmid: 12905462
references.citation: Neurology. 2006 Jul 25;67(2):305-10
references.pmid: 16864824
references.citation: PLoS One. 2008 Mar 12;3(3):e0001757
references.pmid: 18335026
references.citation: N Engl J Med. 1998 May 7;338(19):1359-68
references.pmid: 9571257
references.citation: N Engl J Med. 1969 Sep 25;281(13):701-5
references.pmid: 5821163
references.citation: Springer Semin Immunopathol. 2006 Oct;28(2):83-96
references.pmid: 16972052
references.citation: Arthritis Rheum. 2008 Aug;58(8):2511-7
references.pmid: 18668569
references.citation: Immunity. 2007 Nov;27(5):695-7
references.pmid: 18031693
references.citation: Ann N Y Acad Sci. 1975 Jun 30;254:505-15
references.pmid: 52321