title: Lyme neuroborreliosis: aetiology and diagnosis of facial palsy in children from Tyrol.
abstract: BACKGROUND
  Lyme neuroborreliosis (LNB) is the second most common manifestation of Borrelia burgdorferi sensu lato (s. l.) infection in Europe. LNB is difficult to differentiate from other aetiologies of aseptic meningitis. Diagnostic criteria for LNB in children are not established. Therfore, based on the epidemiology of LNB in children from Tyrol, the aim of our study was to point out the necessity of a clear definition of pediatric LNB to avoid underdiagnosis and overtreatment.
  
  
  METHODS
  All medical charts of patients presented with acute peripheral facial palsy from January 2002 to December 2005 were reviewed. The patients were rediagnosed according to the criteria of the German Society of Neurology (DGN).
  
  
  RESULTS
  We identified 66 patients with peripheral facial palsy. 30 children were handled as B. burgdorferi s. l. infection. 5 patients were overtreated with antibiotic therapy. After reevaluation according to the DGN criteria 7 cases were reclassified as possible, 16 cases as probable and 7 cases as confirmed LNB.
  
  
  CONCLUSIONS
  Utilization of the established DGN criteria for pediatric LNB might help to elucidate the propability of LNB. Prospective studies are required to establish a classification system. A diagnostic tool, based on laboratory and clinical data, should avoid overtreatment of pediatric LNB.
authors.affiliation: Department of Pediatrics, Medical University Innsbruck, Austria. juergen.brunner@uki.at
authors.forename: J
authors.initials: J
authors.lastname: Brunner
authors.forename: G
authors.initials: G
authors.lastname: Moschovakis
authors.forename: M
authors.initials: M
authors.lastname: Prelog
authors.forename: G
authors.initials: G
authors.lastname: Walder
authors.forename: R
authors.initials: R
authors.lastname: Wuerzner
authors.forename: L B
authors.initials: LB
authors.lastname: Zimmerhackl
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D001317:Austria; D015748:Borrelia burgdorferi Group / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005158:Facial Paralysis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D015994:Incidence; D007223:Infant; D020852:Lyme Neuroborreliosis / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008582:Meningitis, Aseptic / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D000907:Antibodies, Bacterial