Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria.
The synthesis and biofilm inhibitory activity of a 30-member aryl amide 2-aminoimidazole library against the three biofilm forming Gram-negative bacteria Escherichia coli, Psuedomonas aeruginosa, and Acinetobacter baumannii is presented. The most active compound identified inhibits the formation of E. coli biofilms with an IC(50) of 5.2 microM and was observed to be non-toxic to planktonic growth, demonstrating that analogues based on an aryl framework are viable options as biofilm inhibitors within the 2-aminoimidazole family.
Bunders
Cynthia A
CA
Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Richards
Justin J
JJ
Melander
Christian
C
D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D018441:Biofilms / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D010933:Plankton / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D054852:Small Molecule Libraries / Q000138:chemical synthesis
D000900:Anti-Bacterial Agents; D007093:Imidazoles; D054852:Small Molecule Libraries; C014973:2-aminoimidazole