title: Acute Chagas' disease in postrenal transplant and treatment with benzonidazole.
abstract: Transplanted organs may act as a route of transmission of infectious diseases, such as Chagas' disease. The aim of this study was to describe the transmission of the Trypanosoma cruzi through a renal transplant and the anatomo-clinical evolution of the patient after treatment with benzonidazole. The patient was a 31-year-old white male from the State of Minas Gerais in Brazil. He had renal failure secondary to diabetes and later received a kidney from a cadaveric donor. The patient was undergoing immunosuppression therapy with azathioprine, cyclosporine A, and prednisone. After the transplant, he developed an acute phase of Chagas' disease and complications from diabetes and died 2 months later. In the autopsy, T cruzi amastigotes were found in the transplanted kidney, heart, bladder, liver, and pancreas. An important reduction in the parasitemia was obtained through the treatment of the infection with benzonidazole; however, the patient died due to complications from diabetes associated with tissue lesions caused by T cruzi.
authors.affiliation: Discipline of General Pathology, Triângulo Mineiro Federal University, Uberaba, the State of Minas Gerais, Brazil.
authors.forename: Alex Eduardo
authors.initials: AE
authors.lastname: Silva
authors.forename: Anna Carolina Fabiana Lúcia
authors.initials: AC
authors.lastname: Silva
authors.forename: Ana Carolina Guimarães
authors.initials: AC
authors.lastname: Faleiros
authors.forename: Camila Souza de Oliveira
authors.initials: CS
authors.lastname: Guimarães
authors.forename: Rosana Rosa Miranda
authors.initials: RR
authors.lastname: Corrêa
authors.forename: Flávia Aparecida
authors.initials: FA
authors.lastname: Oliveira
authors.forename: Dalmo
authors.initials: D
authors.lastname: Correia
authors.forename: Alan César
authors.initials: AC
authors.lastname: Teixeira
authors.forename: Luís Eduardo
authors.initials: LE
authors.lastname: Ramirez
authors.forename: Vicente de Paula Antunes
authors.initials: Vde P
authors.lastname: Teixeira
authors.forename: Marlene Antônia
authors.initials: MA
authors.lastname: dos Reis
mesh_terms: D000208:Acute Disease; D000328:Adult; D014355:Chagas Disease / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011183:Postoperative Complications; D051437:Renal Insufficiency / Q000601:surgery; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole