title: Three-year clinical outcome of percutaneous treatment of  bifurcation lesions in multivessel coronary artery disease  with the sirolimus-eluting stent: insights from the Arterial  Revascularisation Therapies Study, part II (ARTS II).
abstract: OBJECTIVE
  The long-term impact of treating bifurcation lesions on the overall outcome of patients with multivessel coronary disease treated percutaneously with drug-eluting stents is unknown. This analysis determined the influence of bifurcation treatment using sirolimus-eluting stents on 3-year clinical outcomes.
  
  
  RESULTS
  Of the 607 patients (2,160 lesions) in the ARTS II study, 324 patients underwent revascularisation procedures involving treatment of at least one bifurcation (465 lesions). Three-year outcomes were compared to those without bifurcations. Despite more diffuse and complex disease in the bifurcation group, survival free of adverse events was equivalent in the two groups. At 3-years, there was no difference in rate of overall MACCE (20.2% vs. 18.5%, p=NS) or any of the component events between the bifurcation and the non-bifurcation group. There was a trend for a higher rate of definite stent thrombosis in the bifurcation group (4.6 vs 2.1%, p=0.1), but in multivariate analysis the CK value post-procedure served as the only independent predictor of definite stent thrombosis (p=0.015), with the presence of a bifurcation lesion of borderline significance (p=0.056).
  
  
  CONCLUSIONS
  In multivessel disease treated by PCI with DES, the presence of bifurcation disease had no adverse influence on 3-year clinical outcomes.
authors.affiliation: Institut Cardiovasculaire Paris Sud, Massy, France.
authors.forename: Helen C
authors.initials: HC
authors.lastname: Routledge
authors.forename: Thierry
authors.initials: T
authors.lastname: Lefèvre
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.forename: Keith G
authors.initials: KG
authors.lastname: Oldroyd
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.forename: Giulio
authors.initials: G
authors.lastname: Guagliumi
authors.forename: Wolfgang
authors.initials: W
authors.lastname: von Scheidt
authors.forename: Victor
authors.initials: V
authors.lastname: Guetta
authors.forename: Witold
authors.initials: W
authors.lastname: Ruzyllo
authors.forename: Kristel
authors.initials: K
authors.lastname: Wittebols
authors.forename: Dick M
authors.initials: DM
authors.lastname: Goedhart
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D002561:Cerebrovascular Disorders / Q000209:etiology; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D011474:Prosthesis Design; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D020123:Sirolimus / Q000008:administration & dosage*; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020123:Sirolimus