[CD4+ and CD8+ T-lymphocyte counts in human immunodeficiency virus type 1 subtype A-infected patients carrying mutations V77I in protease and/or A62V in reverse transcriptase].
The peripheral blood counts of CD4+, CD8+, and CD4/CD8 in human immunodeficiency virus type 1 subtype A-infected patients were comparatively analyzed with the data of a genetic study of the pol gene. Thirty peripheral blood samples from antiretroviral-naïve patients with grade 3 (sublinical) HIV infection were analyzed. According to the presence or absence of mutations V77I in protease and/or A62V in reverse transcriptase, the patients were divided into 2 study groups. The genetic analysis of the groups indicated that 19.5% of the study samples had no mutations; 75% contained one or both mutations, of them 36% contained both mutations. Immunological study showed that the median CD4+, CD8+, and CD4/CD8 in the patients infected with virus variants containing mutations V77I and/or A62V were increased by 25, 20, and 16%, respectively. The findings suggest that these mutations may be associated with an immune response in HIV-infected patients.
Selimova
L M
LM
Serebrovskaia
L V
LV
Ivanova
L A
LA
Nosik
D N
DN
D000293:Adolescent; D000328:Adult; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D016333:HIV Protease / Q000235:genetics*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation
D054303:HIV Reverse Transcriptase; D016333:HIV Protease