A novel dipeptidomimetic containing a cyclic threonine.
An efficient and simple two-step procedure for the formation of hydroxy-Freidinger lactams is presented. The methodology allows assembly of the cyclic threonine motif (cThr) in solution and on solid support during conventional peptide synthesis.
Sicherl
Frank
F
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. frank.sicherl@contractors.roche.com
Cupido
Tommaso
T
Albericio
Fernando
F
D032701:Biomimetics; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013912:Threonine / Q000138:chemical synthesis / Q000737:chemistry*
D004151:Dipeptides; D007769:Lactams; D013912:Threonine