What types of inappropriate prescribing predict adverse drug reactions in older adults?
Adverse drug events happen all too often in older adults, but we still do not have a clear understanding of potentially modifiable risk factors, with the exception of polypharmacy. This paper critiques the article in this issue of The Annals entitled, "Inappropriate Prescribing Predicts Adverse Drug Events in Older Adults." A validated measure for self-reported adverse drug events was used, along with a modified measure for inappropriate prescribing that we developed nearly 2 decades ago (ie, Medication Appropriateness Index). Besides discussing the strengths and weaknesses of this article, we also recommend future research directions in this area.
Hanlon
Joseph T
JT
Department of Medicine (Geriatrics), University of Pittsburgh, Pittsburgh, PA 15213, USA. jth14@pitt.edu
Schmader
Kenneth E
KE
D000367:Age Factors; D000368:Aged; D011307:Drug Prescriptions / Q000145:classification*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000145:classification / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008508:Medication Errors / Q000145:classification / Q000639:trends; D004364:Pharmaceutical Preparations / Q000145:classification; D019338:Polypharmacy; D011237:Predictive Value of Tests
D004364:Pharmaceutical Preparations
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