European consensus on the medical management of acute radiation syndrome and analysis of the radiation accidents in Belgium and Senegal.
A European consensus concerning the medical management of mass radiation exposure was obtained in 2005 during a conference held by the European Group for Blood and Bone Marrow Transplantation, the Institute of Radioprotection and Nuclear Safety, and the University of Ulm. At the conference, a two-step triage strategy to deal with large masses of radiation-exposed patients was designed. The first step of this strategy concerns the first 48 h and involves scoring the patients exclusively on the basis of their clinical symptoms and biological data. This allows the non-irradiated bystanders and outpatient candidates to be identified. The remaining patients are hospitalized and diagnosis is confirmed after the first 48-h period according to the METREPOL (Medical Treatment Protocols for radiation accident victims) scale. This grades the patients according to the severity of their symptoms. It was also agreed that in the case of acute radiation syndrome (ARS), emergency hematopoietic stem cell (HSC) transplantation is not necessary. Instead, cytokines that promote hematological reconstruction should be administered as early as possible for 14-21 d. Crucial tests for determining whether the patient has residual hematopoiesis are physical dose reconstructions combined with daily blood count analyses. It was agreed that HSC transplantation should only be considered if severe aplasia persists after cytokine treatment. Two recent cases of accidental radiation exposure that were managed successfully by following the European consensus with modification are reviewed here. Thus, a European standard for the evaluation and treatment of ARS victims is now available. This standard may be suitable for application around the world.
Gourmelon
Patrick
P
Institut de Radioprotection et de Sûreté Nucléaire, Laboratoire de radiopathologie et de thérapie expérimentale, BP 17, 92262 Fontenay-aux-Roses, France.
Benderitter
Marc
M
Bertho
Jean Marc
JM
Huet
Christelle
C
Gorin
Norbert Claude
NC
De Revel
Patrick
P
D054508:Acute Radiation Syndrome / Q000628:therapy*; D001530:Belgium; D002959:Civil Defense; D004189:Disaster Planning; D004632:Emergency Medical Services / Q000458:organization & administration; D005060:Europe; D006410:Hematopoiesis / Q000528:radiation effects; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000628:therapy*; D018788:Radioactive Hazard Release; D012675:Senegal; D016896:Treatment Outcome