Dimethyl titanocene Y: a valuable precursor for libraries of cytotoxic titanocene derivatives.
Reaction of the known titanocene Y 2 with methyl lithium at -15 degrees C yields bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dimethyl (dimethyl titanocene Y, 3), a hitherto unknown, surprisingly robust titanium (IV) dimethyl species. Dimethyl titanocene Y was utilized in the preparation of several bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dicarboxylates by the reaction with the free carboxylic acids in fair to good yields. Cytotoxicity of all new compounds has been estimated in Hela S3 cells.
Immel
Timo A
TA
Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstrasse 10, Fach 720, 78457 Konstanz, Germany.
Martin
Josefine T
JT
Dürr
Christoph J
CJ
Groth
Ulrich
U
Huhn
Thomas
T
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D009942:Organometallic Compounds; C432624:dimethyl titanocene