title: Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities.
abstract: Two new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 1-10 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 8-10 exhibited cytotoxic activities with IC(50) values ranging from 3.4 to 6.6microM.
authors.affiliation: Key Laboratory of Modern Chinese Medicine, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Wu
authors.forename: Ka-Wing
authors.initials: KW
authors.lastname: Cheng
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zuo
authors.forename: Ming-Fu
authors.initials: MF
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Lu-Yong
authors.initials: LY
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D027761:Asparagus Plant / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004441:Ecdysterone / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D012503:Saponins; C543297:filiasparoside C; D004441:Ecdysterone