Serendipity strikes again--efficient preparation of lithium tetramethylcuprate(III) via rapid injection NMR.
Lithium tetramethylcuprate(III), Me(4)CuLi, the Cu(III) analog of the Gilman reagent, has been prepared in high yield from halo-Gilman reagents Me(2)CuLi.LiX (X = Cl, Br, I) and 2,3-dichloropropene and found to have surprising thermal stability. The cyano-Gilman reagent (X = CN) follows a different pathway.
Bartholomew
Erika R
ER
Department of Chemistry, University of North Carolina-Charlotte, Charlotte, NC 28223, USA.
Bertz
Steven H
SH
Cope
Stephen K
SK
Murphy
Michael D
MD
Ogle
Craig A
CA
Thomas
Andy A
AA