title: In vitro studies on a class of quinoline containing histamine H3 antagonists.
abstract: A series of quinoline containing histamine H(3) antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring.
authors.affiliation: Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6123, USA. huaqing.liu@abbott.com
authors.forename: Huaqing
authors.initials: H
authors.lastname: Liu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Altenbach
authors.forename: Gilbert J
authors.initials: GJ
authors.lastname: Diaz
authors.forename: Arlene M
authors.initials: AM
authors.lastname: Manelli
authors.forename: Ruth L
authors.initials: RL
authors.lastname: Martin
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Miller
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: Jorge D
authors.initials: JD
authors.lastname: Brioni
authors.forename: Marlon D
authors.initials: MD
authors.lastname: Cowart
mesh_terms: D000818:Animals; D054828:Histamine H3 Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
chemical_list: D054828:Histamine H3 Antagonists; D011804:Quinolines