title: Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.
abstract: The type 5 G protein beta subunit (Gbeta5) can form complexes with members of the regulator of G protein signaling 7 (RGS7) family, but its relevance to neuronal G protein signaling is unclear. We found that mouse RGS7-Gbeta5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA(B) receptors in neurons. Our findings identify a compartmentalization mechanism that is critical for ensuring high temporal resolution of neuronal G protein signaling.
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Keqiang
authors.initials: K
authors.lastname: Xie
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Allen
authors.forename: Saïd
authors.initials: S
authors.lastname: Kourrich
authors.forename: José
authors.initials: J
authors.lastname: Colón-Saez
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Thomas
authors.forename: Kevin
authors.initials: K
authors.lastname: Wickman
authors.forename: Kirill A
authors.initials: KA
authors.lastname: Martemyanov
mesh_terms: D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000235:genetics / Q000378:metabolism*; D018755:GABA Agonists / Q000494:pharmacology; D044387:GTP-Binding Protein beta Subunits / Q000235:genetics / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D006801:Humans; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D020710:RGS Proteins / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels; D018755:GABA Agonists; D044387:GTP-Binding Protein beta Subunits; C094668:Gnb5 protein, mouse; D020710:RGS Proteins; D018080:Receptors, GABA-B; C492038:Rgs7 protein, mouse; D001418:Baclofen
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