title: Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products.
abstract: A combination of an enantioselective conjugate addition/trapping sequence and a ruthenium(iii)-catalyzed domino cyclization provides a concise access to benzo[d]xanthenes found in several anti-influenza active sesquiterpene natural products.
authors.affiliation: Laboratory of Organic Chemistry, ETH Zurich, HCI H 304, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.
authors.forename: Ngoc Duc
authors.initials: ND
authors.lastname: Tran
authors.forename: Martin
authors.initials: M
authors.lastname: Albicker
authors.forename: Lorenz
authors.initials: L
authors.lastname: Schneider
authors.forename: Nicolai
authors.initials: N
authors.lastname: Cramer
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy*; D015394:Molecular Structure; D014966:Xanthenes / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D014966:Xanthenes