[Model of gastroesophageal reflux concomitant with functional constipation in conditions of nitric oxide synthase inhibition].
Gastroesophageal reflux combined with functional constipation prevented bythe introduction of nitric oxide synthase blocker. Gastroesophageal reflux simulated by the administration of nitric oxide donor - methylene blue at fundal department of the stomach and constipation - by free ligation overlaid on the terminal division sigmoid colon of rats. The protective effect of nitric oxide synthase blocker on the gastroesophageal reflux development was demonstrated.
Lychkova
A E
AE
D000818:Animals; D003248:Constipation / Q000150:complications* / Q000201:enzymology / Q000517:prevention & control; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000201:enzymology / Q000517:prevention & control; D005769:Gastrointestinal Motility / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000627:therapeutic use*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester