title: [Salvage radical prostatectomy after external radiotherapy for prostate cancer: indications, morbidity and results. Review from CCAFU prostate section].
abstract: Local recurrence after external radiotherapy for prostate cancer occurs in 30 to 50 % and is often diagnosed by a rising PSA. The absence of local control after radiotherapy is a risk factor of metastases and specific mortality. There are several therapeutic options to treat these patients: surveillance, hormonotherapy and salvage therapies (radical prostatectomy, cystoprostatectomy, brachytherapy, high intensity focused ultrasound [HIFU] and cryotherapy). Hormonotherapy is not a curative treatment and after a couple of years, the disease will progress again. Local salvage therapies are the only treatment to have the potential to cure these patients with the condition of very strict inclusion criteria. Among these therapies, only radical prostatectomy demonstrated his efficacity with a follow-up of 10 years on specific survival and survival without biological progression respectively from 70 to 77 % and from 30 to 43 %. During last decade, morbidity of RP has strongly decreased with a percentage of rectal and ureteral injury at 3 %. Nevertheless, percentage of urinary incontinence remains high from 29 to 50 %. Salvage mini-invasive therapies (cryotherapy, HIFU and cryotherapy) are under constant evolution due to progress of technology. Functional and oncological results are better with last generation devices but need to be evaluated and compared with radical prostatectomy.
authors.affiliation: Service d'urologie, centre hospitalier Lyon-Sud, université Claude-Bernard Lyon 1, 165 chemin du Grand-Revoyet, Pierre-Bénite cedex, France. philippe.paparel@chu-lyon.fr
authors.forename: P
authors.initials: P
authors.lastname: Paparel
authors.forename: M
authors.initials: M
authors.lastname: Soulie
authors.forename: P
authors.initials: P
authors.lastname: Mongiat-Artus
authors.forename: F
authors.initials: F
authors.lastname: Cornud
authors.forename: C
authors.initials: C
authors.lastname: Borgogno
mesh_terms: D005602:France; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D010818:Practice Patterns, Physicians'; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D016879:Salvage Therapy; D012955:Societies, Medical; D011795:Surveys and Questionnaires; D014572:Urology