title: Assessment of a scalp EEG-based automated seizure detection system.
abstract: OBJECTIVE
  The purpose of this study was to evaluate and validate an offline, automated scalp EEG-based seizure detection system and to compare its performance to commercially available seizure detection software.
  
  
  METHODS
  The test seizure detection system, IdentEvent™, was developed to enhance the efficiency of post-hoc long-term EEG review in epilepsy monitoring units. It translates multi-channel scalp EEG signals into multiple EEG descriptors and recognizes ictal EEG patterns. Detection criteria and thresholds were optimized in 47 long-term scalp EEG recordings selected for training (47 subjects, ∼3653h with 141 seizures). The detection performance of IdentEvent was evaluated using a separate test dataset consisting of 436 EEG segments obtained from 55 subjects (∼1200h with 146 seizures). Each of the test EEG segments was reviewed by three independent epileptologists and the presence or absence of seizures in each epoch was determined by majority rule. Seizure detection sensitivity and false detection rate were calculated for IdentEvent as well as for the comparable detection software (Persyst's Reveal®, version 2008.03.13, with three parameter settings). Bootstrap re-sampling was applied to establish the 95% confidence intervals of the estimates and for the performance comparison between two detection algorithms.
  
  
  RESULTS
  The overall detection sensitivity of IdentEvent was 79.5% with a false detection rate (FDR) of 2 per 24h, whereas the comparison system had 80.8%, 76%, and 74% sensitivity using its three detection thresholds (perception score) with FDRs of 13, 8, and 6 per 24h, respectively. Bootstrap 95% confidence intervals of the performance difference revealed that the two detection systems had comparable detection sensitivity, but IdentEvent generated a significantly (p<0.05) smaller FDR.
  
  
  CONCLUSIONS
  The study validates the performance of the IdentEvent™ seizure detection system.
  
  
  CONCLUSIONS
  With comparable detection sensitivity, an improved false detection rate makes the automated seizure detection software more useful in clinical practice.
authors.affiliation: Center for Neuroscience Research, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Kelly
authors.forename: D S
authors.initials: DS
authors.lastname: Shiau
authors.forename: R T
authors.initials: RT
authors.lastname: Kern
authors.forename: J H
authors.initials: JH
authors.lastname: Chien
authors.forename: M C K
authors.initials: MC
authors.lastname: Yang
authors.forename: K A
authors.initials: KA
authors.lastname: Yandora
authors.forename: J P
authors.initials: JP
authors.lastname: Valeriano
authors.forename: J J
authors.initials: JJ
authors.lastname: Halford
authors.forename: J C
authors.initials: JC
authors.lastname: Sackellares
mesh_terms: D000328:Adult; D000465:Algorithms; D004569:Electroencephalography / Q000379:methods* / Q000592:standards* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D015588:Observer Variation; D012535:Scalp / Q000502:physiology*; D012640:Seizures / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D012984:Software / Q000592:standards; D014741:Video Recording / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data
references.citation: Clin Neurophysiol. 2003 Nov;114(11):2156-64
references.pmid: 14580614
references.citation: Clin Neurophysiol. 2005 Feb;116(2):427-42
references.pmid: 15661120
references.citation: J Clin Neurophysiol. 2001 Nov;18(6):545-9
references.pmid: 11779967
references.citation: Stat Med. 2003 Jan 30;22(2):279-90
references.pmid: 12520562
references.citation: Biometrics. 1992 Jun;48(2):577-85
references.pmid: 1637980
references.citation: Clin Neurophysiol. 2003 May;114(5):898-908
references.pmid: 12738437
references.citation: Clin Neurophysiol. 2007 Nov;118(11):2332-43
references.pmid: 17889601
references.citation: Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2297-301
references.pmid: 11607165
references.citation: Clin Neurophysiol. 2004 Oct;115(10):2280-91
references.pmid: 15351370
references.citation: Acta Neurochir Suppl. 2007;97(Pt 2):357-62
references.pmid: 17691324
references.citation: J Clin Neurophysiol. 2008 Jun;25(3):119-31
references.pmid: 18469727
references.citation: Clin Neurophysiol. 2006 Apr;117(4):912-27
references.pmid: 16458594
references.citation: Biometrics. 1977 Mar;33(1):159-74
references.pmid: 843571