Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site.
FNR-dependent activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF, which bind to overlapping targets adjacent to the DNA site for FNR. The NsrR target is inactivated by mutation at the Salmonella enterica serovar Typhimurium nrf promoter.
Browning
Douglas F
DF
School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom. D.F.Browning@bham.ac.uk
Lee
David J
DJ
Spiro
Stephen
S
Busby
Stephen J W
SJ
D001483:Base Sequence; D003574:Cytochrome c Group / Q000235:genetics / Q000378:metabolism; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D048168:Escherichia coli K12 / Q000235:genetics* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D009154:Mutation; D009569:Nitric Oxide / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000502:physiology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D003574:Cytochrome c Group; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C529899:NsrR protein, E coli; D014157:Transcription Factors; D009569:Nitric Oxide; C022302:cytochrome C-552
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