title: A unique adolescent response to reward prediction errors.
abstract: Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural decision value signals varied depending on how value was modeled. This suggests that heightened dopaminergic prediction error responsivity contributes to adolescent reward seeking.
authors.affiliation: Department of Psychology, University of California Los Angeles, Los Angeles, California, USA. jrcohen@berkeley.edu
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Cohen
authors.forename: Robert F
authors.initials: RF
authors.lastname: Asarnow
authors.forename: Fred W
authors.initials: FW
authors.lastname: Sabb
authors.forename: Robert M
authors.initials: RM
authors.lastname: Bilder
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Bookheimer
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Knowlton
authors.forename: Russell A
authors.initials: RA
authors.lastname: Poldrack
mesh_terms: D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology; D000328:Adult; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D003342:Corpus Striatum / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D030141:Feedback, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008606:Mental Processes / Q000502:physiology*; D011337:Probability Learning; D011930:Reaction Time; D012201:Reward; D055815:Young Adult
references.citation: J Neurosci. 2008 May 28;28(22):5623-30
references.pmid: 18509023
references.citation: Science. 2008 Feb 29;319(5867):1264-7
references.pmid: 18309087
references.citation: Biol Psychiatry. 2004 Feb 15;55(4):359-66
references.pmid: 14960288
references.citation: Science. 1996 Sep 6;273(5280):1399-402
references.pmid: 8703077
references.citation: J Neurosci. 2004 Feb 25;24(8):1793-802
references.pmid: 14985419
references.citation: Nat Neurosci. 2002 Feb;5(2):97-8
references.pmid: 11802175
references.citation: Dev Rev. 2008;28(1):62-77
references.pmid: 18688292
references.citation: Science. 1997 Mar 14;275(5306):1593-9
references.pmid: 9054347
references.citation: Science. 2007 Jan 26;315(5811):515-8
references.pmid: 17255512
references.citation: Brain Res Brain Res Rev. 1998 Dec;28(3):309-69
references.pmid: 9858756
references.citation: J Neurosci. 2006 Jun 21;26(25):6885-92
references.pmid: 16793895
references.citation: J Neurosci. 2009 Sep 30;29(39):12315-20
references.pmid: 19793990