alpha-catenin mechanosensing for adherens junctions.
The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation.
Lecuit
Thomas
T
Thomas Lecuit is in IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy, Case 907. 13288 Marseille Cedex 09, France. lecuit@ibdml.univ-mrs.fr
D000199:Actins / Q000378:metabolism; D022005:Adherens Junctions / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D015820:Cadherins / Q000378:metabolism / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009024:Morphogenesis; D051178:alpha Catenin / Q000378:metabolism*
D000199:Actins; D015820:Cadherins; D016023:Integrins; D051178:alpha Catenin
Cell. 2001 Feb 23;104(4):605-17
11239416
J Cell Biol. 2002 Nov 25;159(4):695-705
12446745
Cell. 2005 Dec 2;123(5):769-72
16325573
Cell. 1997 Jan 10;88(1):39-48
9019403
Development. 2005 Sep;132(18):4165-78
16123312
Nature. 2004 Jun 10;429(6992):667-71
15190355
Dev Cell. 2009 Nov;17(5):736-43
19879198
J Cell Biol. 2010 Mar 8;188(5):735-49
20194639
Science. 2009 Jan 30;323(5914):638-41
19179532
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
18093941
Cell. 2005 Dec 2;123(5):889-901
16325582
Nature. 2008 Jun 5;453(7196):751-6
18480755
Curr Top Dev Biol. 2009;89:33-54
19737641
J Cell Biol. 2010 Apr 19;189(2):339-52
20404114