Novel genetic mechanisms for aortic aneurysms.
Aortic aneurysms occur in the thoracic and abdominal sections of the aorta and are a deadly late-age-at-onset disease with complex pathobiology. Currently, the number of published genome-wide analyses including microarray-based expression profiling, DNA linkage studies, and genetic association studies is still limited and it is difficult to make generalizations about the disease pathogenesis or genetic risk factors contributing to aortic aneurysms, but it appears that thoracic aortic aneurysms differ in many ways from abdominal aortic aneurysms. Characterization of diseases at the molecular level is likely to lead to more accurate diagnoses and the use of "genomic nosology" of disease. The biggest future challenge will be to translate the genomic information to the clinic and improve our understanding of the disease processes, help us to develop better diagnostic tools, and lead to the design of new ways to manage aortic aneurysms in the era of personalized medicine.
Tromp
Gerard
G
Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, PA 17822-2611, USA. gctromp@geisinger.edu
Kuivaniemi
Helena
H
Hinterseher
Irene
I
Carey
David J
DJ
D000368:Aged; D001014:Aortic Aneurysm / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012737:Sex Factors; D055815:Young Adult
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