title: [Effects of pravastatin on the proliferation and invasion of human hepatocarcinoma HepG2 cell line].
abstract: OBJECTIVE
  To observe the effects of pravastatin on the proliferation and invasion of human hepatocarcinoma HepG2 cell line.
  
  
  METHODS
  The effects of pravastatin on the proliferation, migration and invasion of HepG2 cells was observed by MTT assay, Boyden chamber assay and motility assay. p38 activity was measured, and the expression of p-p38, MKP-1, RhoC and MMP-2 was analyzed by Western blot.
  
  
  RESULTS
  Pravastatin inhibited the proliferation of HepG2 cells. The intracellular p38 activity and expressions of p-p38, RhoC and MMP-2 were decreased, while MKP-1 expression was elevated in pravastatin treated cells. In addition, pravastatin inhibited the invasion and motility.
  
  
  CONCLUSIONS
  Pravastatin can inhibit the proliferation and invasion of HepG2 cells.
authors.affiliation: Department of Infectious Diseases, the Second Hospital of Gansu Province, Lanzhou, China. zhangwenjie718@163.com
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Yang
authors.forename: Shu-ju
authors.initials: SJ
authors.lastname: Tian
authors.forename: Zhao-xia
authors.initials: ZX
authors.lastname: Li
authors.forename: Yan-xuan
authors.initials: YX
authors.lastname: Gong
authors.forename: Yan
authors.initials: Y
authors.lastname: Qu
authors.forename: Wei-wu
authors.initials: WW
authors.lastname: Mao
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D017035:Pravastatin / Q000494:pharmacology*
chemical_list: D020778:Matrix Metalloproteinase 2; D017035:Pravastatin