title: Enzymatic preparation of arbutin derivatives: lipase-catalyzed direct acylation without the need of vinyl ester as an acyl donor.
abstract: Direct and regioselective acylation of arbutin with aromatic or aliphatic acid using a lipase obtained from Candida antarctica in an organic solvent was investigated. We achieved the enzymatic synthesis of feruloyl arbutin and lipoyl arbutin without the need of vinyl ferulate and vinyl lipoate as acyl donors, respectively.
authors.affiliation: Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan. ishihara@dls.ous.ac.jp
authors.forename: Kohji
authors.initials: K
authors.lastname: Ishihara
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Katsube
authors.forename: Nozomi
authors.initials: N
authors.lastname: Kumazawa
authors.forename: Mari
authors.initials: M
authors.lastname: Kuratani
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Masuoka
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000215:Acylation; D001104:Arbutin / Q000031:analogs & derivatives*; D002175:Candida / Q000201:enzymology; D002384:Catalysis; D004800:Enzymes, Immobilized / Q000378:metabolism; D004952:Esters; D005227:Fatty Acids / Q000737:chemistry; D005419:Flavonoids / Q000096:biosynthesis* / Q000737:chemistry; D008049:Lipase / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry; D059808:Polyphenols
chemical_list: D004800:Enzymes, Immobilized; D004952:Esters; D005227:Fatty Acids; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D001104:Arbutin; D008049:Lipase