Aqueous garlic extracts prevent oxidative stress and vascular remodeling in an experimental model of metabolic syndrome.
The organosulfur profile and the effect on oxidative stress and vascular remodeling in fructose-fed rats (FFR) were evaluated in Fuego INTA and Morado INTA garlic cultivars. Wistar rats were fed either normal rat chow (control) or the same diet plus 10% fructose in drinking water. During the last 6 weeks of a 12 week period of the corresponding diet, a subgroup of control and FFR received an aqueous extract of Fuego INTA and Morado INTA. Fuego INTA showed higher levels of total thiosulfinates, allicin, and pungency than Morado INTA. FFR showed an increase of systolic blood pressure, aortic NAD(P)H oxidase activity, plasma thiobarbituric acid reactive substances, and vascular remodeling that was significantly reduced after both garlic administrations. The beneficial effect was slightly higher when Fuego INTA was administered. Both aqueous garlic extracts prevent oxidative stress and vascular remodeling in rats with metabolic syndrome, suggesting the existence of slight differences among cultivars.
Vazquez-Prieto
Marcela Alejandra
MA
Area de Fisiología Patologica, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
González
Roxana Elizabeth
RE
Renna
Nicolás Federico
NF
Galmarini
Claudio Rómulo
CR
Miatello
Roberto Miguel
RM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control*; D018384:Oxidative Stress; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000737:chemistry / Q000187:drug effects / Q000503:physiopathology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances