title: Solid ovarian tumours in childhood: a 35-year review in a single institution.
abstract: OBJECTIVE
  Solid ovarian tumours are uncommon in childhood. Our aim is to evaluate the outcomes in a single institution over 35 years.
  
  
  METHODS
  We reviewed their clinical presentation, management, pathology and outcomes from 1972 to 2007.
  
  
  RESULTS
  Fifty-three patients, with a median age of 9.2 years (range 0.9-14.2), were registered. Common symptoms at presentation were abdominal pain (75.8%) and abdominal mass (57.4%). Histopathological diagnoses were: 26 mature teratoma, 10 immature teratoma, 8 dysgerminoma, 5 granulosa cell tumours, 2 yolk sac tumours, 1 gonadoblastoma and 1 embryonal carcinoma. Staging (FIGO) for malignant/borderline tumours was: 17 stage I, 1 stage II, 8 stage III and 1 stage IV. Unilateral salpingo-oophorectomy was performed in 47 cases. Sixteen patients underwent chemotherapy after surgery (15 with platinum-based regimen) and postoperative radiotherapy was given in 5 cases. Recurrence was observed in 2 patients and one died (stage III immature teratoma) after a second relapse despite multiple chemotherapy, surgery and radiotherapy. Five-year OS and 5-year EFS were 97% and 94% respectively.
  
  
  CONCLUSIONS
  Although rare, ovarian tumours must be included in the differential diagnosis of abdominal pain in childhood. Our results confirm their excellent prognosis using conservative surgery and platinum-based chemotherapy. The key point is to maintain excellent outcome while reducing associated morbidity and preserving fertility.
authors.affiliation: Paediatric Oncology Unit, Hospital Universitario Infantil La Fe, Valencia, Spain. maradres@hotmail.com
authors.forename: M M
authors.initials: MM
authors.lastname: Andrés
authors.forename: E
authors.initials: E
authors.lastname: Costa
authors.forename: A
authors.initials: A
authors.lastname: Cañete
authors.forename: L
authors.initials: L
authors.lastname: Moreno
authors.forename: V
authors.initials: V
authors.lastname: Castel
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy*; D010052:Ovariectomy; D011878:Radiotherapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
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