title: Social stress reactivity alters reward and punishment learning.
abstract: To examine how stress affects cognitive functioning, individual differences in trait vulnerability (punishment sensitivity) and state reactivity (negative affect) to social evaluative threat were examined during concurrent reinforcement learning. Lower trait-level punishment sensitivity predicted better reward learning and poorer punishment learning; the opposite pattern was found in more punishment sensitive individuals. Increasing state-level negative affect was directly related to punishment learning accuracy in highly punishment sensitive individuals, but these measures were inversely related in less sensitive individuals. Combined electrophysiological measurement, performance accuracy and computational estimations of learning parameters suggest that trait and state vulnerability to stress alter cortico-striatal functioning during reinforcement learning, possibly mediated via medio-frontal cortical systems.
authors.affiliation: Department of Psychology, University of Arizona, Tucson, AZ, USA. jim.f.cav@gmail.com
authors.forename: James F
authors.initials: JF
authors.lastname: Cavanagh
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Frank
authors.forename: John J B
authors.initials: JJ
authors.lastname: Allen
mesh_terms: D000293:Adolescent; D001931:Brain Mapping / Q000379:methods; D003071:Cognition / Q000502:physiology; D004569:Electroencephalography; D005246:Feedback; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D011237:Predictive Value of Tests; D011678:Punishment / Q000523:psychology*; D012054:Reinforcement, Psychology; D012201:Reward; D012919:Social Behavior; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology*; D055815:Young Adult
references.citation: Can J Psychiatry. 2009 Jan;54(1):6-15
references.pmid: 19175975
references.citation: Brain Res. 2009 Nov 24;1299:74-94
references.pmid: 19595993
references.citation: Clin Neurophysiol. 2007 Mar;118(3):645-68
references.pmid: 17223380
references.citation: Clin Neurophysiol. 2006 Feb;117(2):348-68
references.pmid: 16356767
references.citation: Biol Psychiatry. 2007 Jan 15;61(2):253-60
references.pmid: 17150197
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16311-6
references.pmid: 17913879
references.citation: Trends Cogn Sci. 1998 Nov 1;2(11):436-47
references.pmid: 21227275
references.citation: J Neurosci. 1993 Sep;13(9):3839-47
references.pmid: 8396170
references.citation: Psychol Bull. 2004 May;130(3):355-91
references.pmid: 15122924
references.citation: J Neurosci. 2006 Dec 20;26(51):13264-72
references.pmid: 17182776
references.citation: Neuroimage. 2005 Dec;28(4):1007-13
references.pmid: 16055352
references.citation: Biol Psychol. 2007 Feb;74(2):243-62
references.pmid: 17070982
references.citation: Cereb Cortex. 2007 Dec;17(12):2796-804
references.pmid: 17322559
references.citation: Psychoneuroendocrinology. 2008 Jan;33(1):41-53
references.pmid: 17964737
references.citation: Nat Neurosci. 2004 May;7(5):497-8
references.pmid: 15097995
references.citation: Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17951-6
references.pmid: 19822738
references.citation: J Neurosci. 2004 Mar 17;24(11):2825-31
references.pmid: 15028776
references.citation: Nat Neurosci. 2007 Sep;10(9):1214-21
references.pmid: 17676057
references.citation: Brain Res. 2008 Oct 31;1238:127-42
references.pmid: 18760262
references.citation: Neuron. 2005 Aug 18;47(4):495-501
references.pmid: 16102533
references.citation: J Neurosci. 2009 Jan 7;29(1):98-105
references.pmid: 19129388
references.citation: Neuropsychopharmacology. 2008 Jul;33(8):2033-41
references.pmid: 17957215
references.citation: Neuropsychologia. 2009 Jul;47(8-9):1978-87
references.pmid: 19428431
references.citation: J Neurosci. 1994 May;14(5 Pt 2):3333-40
references.pmid: 8182476
references.citation: Neuroimage. 2010 Feb 15;49(4):3198-209
references.pmid: 19969093
references.citation: Cognition. 2009 Dec;113(3):314-328
references.pmid: 19285311
references.citation: Psychol Rev. 2002 Oct;109(4):679-709
references.pmid: 12374324
references.citation: Neuropsychopharmacology. 2007 Jul;32(7):1583-99
references.pmid: 17164816
references.citation: Science. 2004 Dec 10;306(5703):1940-3
references.pmid: 15528409
references.citation: Cogn Affect Behav Neurosci. 2007 Dec;7(4):297-308
references.pmid: 18189003
references.citation: J Neurosci. 2005 Dec 14;25(50):11730-7
references.pmid: 16354931
references.citation: J Neurosci. 2009 Jun 3;29(22):7330-40
references.pmid: 19494154
references.citation: J Neurosci Methods. 2004 Mar 15;134(1):9-21
references.pmid: 15102499
references.citation: Nat Neurosci. 2005 Mar;8(3):365-71
references.pmid: 15696163