title: [Effects of alpha1 adrenoceptor antagonist, naftopidil, on non-bacterial chronic pelvic pain syndrome in patients with lower urinary tract syndrome: evaluation of its efficacy using NIH-CPSI after 4-week treatment].
abstract: We investigated the effect of naftopidil an alpha1 adrenoceptor antagonist on non-bacterial chronic pelvic pain syndrome (CPPS) in middle-aged and older male patients with lower urinary tract symptoms (LUTS). Patients who had given informed consent were treated with naftopidil (daily 50 mg), and were evaluated using the Japanese edition of NIH chronic prostatitis symptom index (NIH-CPSI) and the international prostate symptom score (IPSS) at 2 and 4 weeks after the administration. The NIH-CPSI (total score) was significantly improved by naftopidil for 4 weeks (11.5+/-6.0, n=62, p<0.001) as compared with the baseline (19.8+/-5.7). Other items of NIH-CPSI of pain, urinary symptoms, and quality of life-impact, and IPSS were also ameliorated by naftopidil as compared with the baseline (n=62, p<0.001 each). One patient had slight dizziness, but no severe adverse events were noted in any patient. It is suggested that naftopidil could be an effective and safe therapeutic option for middle-aged and older male LUTS patients with CPPS.
authors.affiliation: Department of Urology, Morioka Yuai Hospital.
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ohinata
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Fujishima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hirano
authors.forename: Takuji
authors.initials: T
authors.lastname: Kudou
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Funaki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Akasaka
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage*; D000368:Aged; D002908:Chronic Disease; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000008:administration & dosage*; D017699:Pelvic Pain / Q000175:diagnosis / Q000188:drug therapy*; D010879:Piperazines / Q000008:administration & dosage*; D011472:Prostatitis / Q000175:diagnosis / Q000188:drug therapy*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013577:Syndrome; D013997:Time Factors
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D009281:Naphthalenes; D010879:Piperazines; C064357:naftopidil