Massive eosinophilic pleural effusion preceding vasculitic symptoms in Churg-Strauss syndrome.
We report a case of Churg-Strauss syndrome (CSS) presenting as a massive pleural effusion. A 52-year-old asthmatic Japanese woman presented with progressive dyspnea caused by an eosinophilic pleural effusion (EPE). She also had chronic sinusitis, skin lesions and blood eosinophilia, but no antineutrophil cytoplasmic antibodies. Skin biopsy and the late onset of mononeuritis multiplex led to the diagnosis of CSS. The pleural effusion resolved soon after corticosteroid treatment was started. CSS is rare as a cause of EPE, but should be included in the differential diagnosis of EPE in asthmatic patients. This is the first report showing that EPE can precede other vasculitic symptoms in CSS.
Tanizawa
Kiminobu
K
Department of Respiratory Medicine, Tenri Hospital. tanizawa@kuhp.kyoto-u.ac.jp
Kaji
Yusuke
Y
Tanaka
Eisaku
E
Inoue
Tetsuro
T
Sakuramoto
Minoru
M
Minakuchi
Masayoshi
M
Maeda
Yuji
Y
Maniwa
Ko
K
Terada
Kunihiko
K
Goto
Shunsuke
S
Takeda
Tomoshi
T
Okamoto
Masaki
M
Hashimoto
Seishu
S
Noma
Satoshi
S
Kobashi
Yoichiro
Y
Taguchi
Yoshio
Y
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy; D001707:Biopsy, Needle; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D004802:Eosinophilia / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis* / Q000188:drug therapy; D013902:Radiography, Thoracic; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones