Navigating the nucleotide excision repair threshold.
Nucleotide excision repair (NER) is the primary DNA repair pathway that removes helix-distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and repair reactions have been identified and extensively characterized, and the NER pathway has been reconstituted in vitro, the regulatory pathways that govern the threshold levels of NER have not been fully elucidated. This mini-review focuses on recently discovered transcriptional and post-translational mechanisms that specify the capacity of NER, and suggests the potential implications of modulating NER activity in cancer prevention and therapeutic intervention.
Liu
Liren
L
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA.
Lee
Jennifer
J
Zhou
Pengbo
P
D000818:Animals; D001683:Biological Clocks / Q000235:genetics; D002940:Circadian Rhythm / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D014158:Transcription, Genetic; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics / Q000378:metabolism
D051760:Xeroderma Pigmentosum Group A Protein
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10320-5
18650382
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2588-93
16473935
Mutat Res. 1979 Sep;62(2):311-23
503098
Mol Cell Biol. 1995 Oct;15(10):5396-402
7565690
Cancer Biol Ther. 2002 Mar-Apr;1(2):177-86
12170778
J Cell Biol. 2004 Jul 5;166(1):27-36
15226310
DNA Repair (Amst). 2003 Sep 18;2(9):947-54
12967652
Oncogene. 2002 Dec 16;21(58):8949-56
12483511
EMBO J. 1994 May 15;13(10):2388-92
8194528
Mutat Res. 2001 Feb 25;485(1):3-13
11341989
Genes Dev. 2000 Feb 1;14(3):349-59
10673506
Mol Cell Biol. 1996 Sep;16(9):4852-61
8756644
Mutat Res. 2008 Mar-Apr;658(3):271-86
18321768
DNA Repair (Amst). 2009 Apr 5;8(4):461-9
19217833
J Biol Chem. 1998 Dec 11;273(50):33327-32
9837906
DNA Repair (Amst). 2004 Oct 5;3(10):1285-95
15336624
Mol Cell. 2001 Jul;8(1):213-24
11511374
Cell. 1996 Sep 6;86(5):811-22
8797827
Mol Cell. 2009 May 14;34(4):451-60
19481525
Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8876-80
7568035
Mol Cell. 2006 May 19;22(4):489-99
16713579
Prog Nucleic Acid Res Mol Biol. 2005;79:183-235
16096029
Nat Rev Cancer. 2001 Oct;1(1):22-33
11900249
Mol Cell. 2006 May 5;22(3):383-94
16678110
Nucleic Acids Res. 2004 Dec 15;32(22):6490-500
15601997
EMBO J. 1997 Nov 3;16(21):6559-73
9351836
DNA Repair (Amst). 2009 Jun 4;8(6):767-76
19332393
Mol Cell Biol. 2007 Apr;27(8):3199-210
17296735
Cell. 2005 May 6;121(3):387-400
15882621
DNA Repair (Amst). 2005 Jul 28;4(8):926-38
15916927
DNA Repair (Amst). 2004 Nov 2;3(11):1409-23
15380097
EMBO J. 2003 Apr 1;22(7):1665-75
12660172
Mol Cell. 2009 Nov 25;36(4):642-53
19941824
Mutat Res. 1982 Jun;94(2):421-34
7110182
J Biol Chem. 1999 Dec 10;274(50):35309-12
10585395
J Virol. 2000 Jul;74(14):6408-17
10864652
Genes Dev. 1994 Oct 15;8(20):2401-15
7958905
J Biol Chem. 2008 Oct 24;283(43):29045-52
18703516
DNA Repair (Amst). 2009 Jul 4;8(7):795-802
19376752
DNA Repair (Amst). 2005 May 2;4(5):571-82
15811629
EMBO J. 2006 Mar 22;25(6):1285-94
16482220
J Biol Chem. 1995 Sep 1;270(35):20862-9
7657672
Cell. 1990 Aug 24;62(4):777-91
2167179
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3746-51
11904430
Genes Dev. 2008 Sep 15;22(18):2496-506
18794347
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):424-8
9892649
Mutat Res. 1982 Aug;95(2-3):493-503
6956805
Nature. 2002 Aug 29;418(6901):935-41
12198538
Oncogene. 1995 Mar 16;10(6):1053-9
7700629
J Biol Chem. 1996 Aug 9;271(32):19451-6
8702634
Mol Biol Cell. 2001 Oct;12(10):2987-3003
11598186
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2864-7
19164551
J Biol Chem. 2000 Apr 14;275(15):11492-7
10753968
Science. 1993 Apr 2;260(5104):58-63
8465201
J Biol Chem. 1997 Oct 31;272(44):28073-80
9346961
Cancer Biol Ther. 2005 Dec;4(12):1409-14
16357511
J Biol Chem. 2008 Nov 21;283(47):32553-61
18806262
Science. 1988 Oct 28;242(4878):564-7
3175673
Cell. 2003 May 2;113(3):357-67
12732143
J Biol Chem. 2003 Nov 21;278(47):46906-10
12944386
Biochemistry. 1995 Apr 18;34(15):5011-7
7711023
Curr Genet. 2002 Oct;42(1):9-20
12420141
Nature. 1994 Sep 29;371(6496):432-5
8090225
Mol Cell Biol. 2000 Jun;20(12):4393-404
10825202
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12985-90
12242345
J Biol Chem. 2001 Dec 21;276(51):48175-82
11673459
J Biol Chem. 2005 Sep 16;280(37):32184-92
16033759
Mutat Res. 1983 Aug;110(2):401-12
6877263
Mol Cell Biol. 2001 Apr;21(7):2281-91
11259578
Nature. 2007 Apr 19;446(7138):876-81
17443180
Oncogene. 2007 May 24;26(24):3572-81
17173070
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9124-9
10430906
Nature. 2001 May 17;411(6835):366-74
11357144
Genes Dev. 2003 Jul 1;17(13):1630-45
12815074
Mol Cell. 1998 Nov;2(5):571-80
9844630
Mol Cell. 2000 Apr;5(4):737-44
10882109
J Mol Biol. 2000 Jul 7;300(2):275-90
10873465
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10394-8
7937961
Mol Cell Biol. 1993 Dec;13(12):7757-65
8246991
Mutat Res. 1994 Nov;315(3):229-37
7526200
Genes Dev. 2008 Sep 15;22(18):2507-19
18794348
Nucleic Acids Res. 2002 Jun 1;30(11):2588-98
12034848
Carcinogenesis. 2004 Jun;25(6):1033-43
14742321
Cancer Res. 2005 Nov 15;65(22):10298-306
16288018
Mol Cell. 2007 Jul 20;27(2):311-23
17643379
Genes Dev. 2006 Jun 1;20(11):1429-34
16751180
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6628-33
12732713
Mol Cell. 1998 Aug;2(2):223-32
9734359