Immunohistochemical study of cytokeratin expression in nevus sebaceous.
BACKGROUND
The histogenesis of nevus sebaceous (NS) is unclear.


METHODS
To elucidate the histogenesis of NS, cytokeratin (CK) profiles were examined immunohistochemically using 10 anti-keratin antibodies in the three stages of NS.


RESULTS
In the first stage, stratified differentiated keratins (CK1 and 10) were reduced, and basal keratin (CK14) was increased in the epidermis and primitive follicular structure (PFS). In the second stage, in addition to reduced CK1 and CK10 expressions and increased CK14 expression, CK17 expression was strongly expressed in the sebaceous ducts in proportion to the development of sebaceous gland. In the third stage, CK14, CK17 and CK19 were expressed in secondary tumors. CK16 was not detected throughout all stages of NS.


CONCLUSIONS
These results suggest that NS is not hyperproliferative but involves hamartomatous differentiation with undifferentiated keratins.
Kurokawa
Ichiro
I
Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan. kuroichi@clin.medic.mie-u.ac.jp
Nishimura
Keisuke
K
Yamanaka
Kei-ichi
K
Isoda
Ken-ichi
K
Taniguchi
Yoshiki
Y
Tsuruta
Daisuke
D
Tsubura
Airo
A
Mizutani
Hitoshi
H
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053547:Keratin-14 / Q000378:metabolism; D053536:Keratin-16 / Q000378:metabolism; D053537:Keratin-17 / Q000378:metabolism; D007633:Keratins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D054000:Nevus, Sebaceous of Jadassohn / Q000378:metabolism* / Q000473:pathology; D012627:Sebaceous Glands / Q000378:metabolism
D053547:Keratin-14; D053536:Keratin-16; D053537:Keratin-17; D007633:Keratins