title: Mechanoreceptors found in a posterior cruciate ligament from a well-functioning total knee arthroplasty retrieval.
abstract: Histologic analysis of the posterior cruciate ligament has been reported in the normal and osteoarthritic knee but not after cruciate-retaining (CR) total knee arthroplasty (TKA). Retention of the posterior cruciate ligament during TKA has been debated as to whether it is beneficial in stability and function. If the presence of mechanoreceptors is shown to be maintained in CR TKA, then there may be an argument for retention. This case report used a retrieval of a well-functioning TKA specimen that had a CR TKA. To prove the presence of mechanoreceptors within the ligament, immunohistochemistry techniques using S100 protein and neurofilament protein were used. This specimen had pacini and lamellar type of mechanoreceptors present on immunohistochemistry analysis. The presence or retention of mechanoreceptors and innervations of the ligament may indicate an advantage when retained during TKA.
authors.affiliation: InMotion Orthopaedic Research Center, Memphis, TN, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Mihalko
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Creek
authors.forename: Michelle N
authors.initials: MN
authors.lastname: Mary
authors.forename: John L
authors.initials: JL
authors.lastname: Williams
authors.forename: David E
authors.initials: DE
authors.lastname: Komatsu
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000295:instrumentation*; D001696:Biomechanical Phenomena; D020878:Device Removal; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D007720:Knee Prosthesis; D008465:Mechanoreceptors / Q000166:cytology* / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D016119:Posterior Cruciate Ligament / Q000166:cytology* / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D016900:Neurofilament Proteins; D009418:S100 Proteins