Cipura paludosa attenuates long-term behavioral deficits in rats exposed to methylmercury during early development.
In the present study, we evaluated the effects of the ethanolic extract (EE) of Cipura paludosa on locomotor, and anxiety- and depression-like behaviors of adult rats exposed to MeHg during early development. Additionally, the antioxidant enzymes catalase (CAT) and selenium-glutathione peroxidase (Se-GPx) were measured in cortical, hippocampal, and cerebellar tissues. Pregnant Wistar rats were treated by gavage with a single dose of MeHg (8 mg/kg) on gestational day 15, the developmental stage critical for cortical neuron proliferation. Moreover, prenatal MeHg exposure inhibited CAT and Se-GPx in the cortex and cerebellum. Chronic treatment with the EE of C. paludosa attenuated these emotional and antioxidant deficits induced by prenatal MeHg toxic exposure. This study provides novel evidence that developmental exposure to MeHg can affect not only cognitive functions but also locomotor, and anxiety- and depression-like behaviors.
Lucena
Greice M R S
GM
Faculdade de Ciências da Saúde, Curso de Ciências Farmacêuticas, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro (Asa Norte), 70910-900 DF, Brazil.
Porto
Fábio A
FA
Campos
Elida G
EG
Azevedo
Mariangela S
MS
Cechinel-Filho
Valdir
V
Prediger
Rui D S
RD
Ferreira
Vania M M
VM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D027621:Iridaceae / Q000737:chemistry*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D018782:Maze Learning / Q000187:drug effects; D008767:Methylmercury Compounds / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects; D038081:Organogenesis / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D008767:Methylmercury Compounds; D010936:Plant Extracts; D014874:Water Pollutants, Chemical; D002374:Catalase; D005979:Glutathione Peroxidase