title: Bisnicalaterines B and C, atropisomeric bisindole alkaloids from Hunteria zeylanica, showing vasorelaxant activity.
abstract: Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hara
authors.forename: Alfarius E
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Masatomo
authors.initials: M
authors.lastname: Sugai
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kawahara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects*; D029062:Apocynaceae / Q000737:chemistry* / Q000145:classification; D002478:Cells, Cultured; D002942:Circular Dichroism; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D009924:Organ Culture Techniques; D024301:Plant Bark / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D026121:Indole Alkaloids; D014665:Vasodilator Agents; C552158:bisnicalaterine B; C552159:bisnicalaterine C