Understanding eukaryotic chemotaxis: a pseudopod-centred view.
Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.
Insall
Robert H
RH
Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK r.insall@beatson.gla.ac.uk
D000818:Animals; D005075:Biological Evolution; D002450:Cell Communication; D002633:Chemotaxis; D056890:Eukaryota / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
Biosystems. 1994;33(2):75-87
7811960
J Cell Sci. 1999 Sep;112 ( Pt 17):2867-74
10444381
Cell. 1994 Oct 21;79(2):303-14
7954798
Trends Cell Biol. 2000 Nov;10(11):466-73
11050418
Curr Biol. 2007 May 1;17(9):813-7
17462897
J Cell Biol. 1995 Jun;129(6):1667-75
7790362
J Cell Sci. 1993 Dec;106 ( Pt 4):1005-13
7510298
J Cell Sci. 2004 Jun 15;117(Pt 14):2925-35
15161938
Philos Trans R Soc Lond B Biol Sci. 1975 Nov 6;272(915):181-92
1814
Dev Cell. 2007 Apr;12(4):603-14
17419997
J Cell Sci. 2008 Nov 1;121(Pt 21):3589-97
18840645
Science. 2008 Oct 17;322(5900):390-5
18927383
Cell Motil Cytoskeleton. 1992;22(3):211-23
1423666
J Cell Biol. 2008 Feb 25;180(4):747-53
18299345
J Cell Biol. 1998 Jun 29;141(7):1529-37
9647646
Nat Cell Biol. 2002 Jul;4(7):509-13
12080346
PLoS One. 2008;3(11):e3734
19011688
PLoS Biol. 2007 Sep;5(9):e221
17696648
J Biol Chem. 2003 Jun 6;278(23):20445-8
12672811
J Cell Biol. 2005 Dec 5;171(5):883-92
16314431
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11342-7
19549839
J Cell Biol. 2007 Dec 17;179(6):1247-59
18086920
J Cell Sci. 2008 Jan 1;121(Pt 1):120-7
18073238
J Cell Sci. 2008 Jan 15;121(Pt 2):205-14
18187452
Eur J Cell Biol. 2008 Oct;87(10):845-61
18554748
Nat Cell Biol. 2007 Feb;9(2):193-200
17220879
J Cell Sci. 2003 Nov 1;116(Pt 21):4331-43
12966168
Development. 2009 Jan;136(1):41-50
19060332
Cell. 2002 May 31;109(5):599-610
12062103
Nature. 2006 Jul 27;442(7101):457-60
16871217
PLoS One. 2008 May 07;3(5):e2093
18461173
Dev Cell. 2005 Feb;8(2):215-27
15691763
Dev Cell. 2001 Dec;1(6):743-7
11740936
Cell. 1998 Oct 2;95(1):81-91
9778249
Nat Rev Mol Cell Biol. 2004 Aug;5(8):626-34
15366706
PLoS One. 2009;4(4):e5253
19384419
Cell Motil Cytoskeleton. 2002 Oct;53(2):150-62
12211111
J Cell Sci. 1984 Jun;68:139-51
6092396
Nat Cell Biol. 2007 Jan;9(1):86-91
17173040
Annu Rev Cell Biol. 1988;4:649-86
2848555
Nat Cell Biol. 2007 Jan;9(1):15-7
17199126
Nature. 1967 Jan 21;213(5073):256-60
6030602
J Cell Sci. 1981 Dec;52:1-10
7037797
Curr Biol. 2006 Apr 4;16(7):717-22
16581519
Annu Rev Biophys. 2010;39:265-89
20192768
J Cell Biol. 2004 Aug 30;166(5):697-708
15337778
Curr Biol. 2009 Feb 10;19(3):253-9
19200726
Curr Biol. 2007 Jan 9;17(1):12-9
17208180
Biochem Cell Biol. 1997;75(3):277-86
9404647
PLoS One. 2009 Aug 31;4(8):e6842
19718261
J Cell Sci. 2008 Oct 1;121(Pt 19):3196-206
18782862