[Optimization of Glycyrrhiza flavonoid and ferulic acid cream by reflect-line orthogonal simplex method].
OBJECTIVE
To optimize the formula of Glycyrrhiza flavonoid and ferulic acid cream and set up its quality control parameters.


METHODS
Reflect-line orthogonal simplex method was used to optimize the main factors such as amount of Myrj52-glyceryl monostearate and dimethicone, based on the appearance, spreadability and stability of the cream.


RESULTS
9.0% Myrj52-glyceryl monostearate (3:2) and 2.5% dimethicone were chosen in prescription. The prepared cream presented a good stability after being placed 24 h at 5 degrees C, 25 degrees C and 37 degrees C respectively,and its spreadability suited with the property of semi-fluid cream.


CONCLUSIONS
[corrected] The formula of Glycyrrhiza flavonoid and ferulic acid cream is suitable, and its quality is stable. The reflect-line orthogonal simplex method is suitable for the formula optimization of cream.
Liu
Sheng
S
Affiliated Provincial Hospital,Anhui Medical University, Hefei 230001, China. lslcclhl@163.com
Xie
Jun
J
Chen
Xiangqing
X
Yang
Liqiang
L
Su
Dan
D
Fang
Yan
Y
Yu
Na
N
Fang
Wei
W
D003373:Coumaric Acids / Q000737:chemistry*; D004304:Dosage Forms; D004339:Drug Compounding; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D006035:Glycyrrhiza / Q000737:chemistry*
D003373:Coumaric Acids; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C004999:ferulic acid