Cardiovascular consequences of obese and nonobese obstructive sleep apnea.
Current evidence suggests a role for obstructive sleep apnea (OSA) in the development of cardiovascular disorders. However, obesity is an active confounder in this relationship. OSA and obesity share similar pathophysiologic mechanisms potentially leading to cardiovascular disorders. Presence of OSA in obese patients may further contribute to adverse cardiovascular outcomes when compared with each condition in isolation. In this review the authors explore the complex relationship between OSA and obesity (and nonobese subjects) in the development of cardiovascular disorders.
Ramar
Kannan
K
Division of Pulmonary, Sleep and Critical Care Medicine, Center for Sleep Medicine, Mayo Clinic, 200 First Street South West, Rochester, MN 55901, USA. ramar.kannan@mayo.edu <ramar.kannan@mayo.edu>
Caples
Sean M
SM
D002318:Cardiovascular Diseases / Q000209:etiology*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D009765:Obesity / Q000150:complications*; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000209:etiology* / Q000503:physiopathology
Am J Respir Crit Care Med. 1996 Jan;153(1):250-4
8542124
Thorax. 2006 Dec;61(12):1083-90
16928705
J Am Coll Cardiol. 2003 Aug 20;42(4):677-9
12932600
J Diabetes Complications. 2000 May-Jun;14(3):154-74
10989324
Am J Respir Crit Care Med. 2009 Oct 15;180(8):788-93
19644043
Am J Physiol Cell Physiol. 2002 Feb;282(2):C227-41
11788333
Prev Med. 1987 Mar;16(2):235-51
3588564
Neth J Med. 1999 May;54(5):202-6
10365562
Circulation. 2004 Jul 27;110(4):364-7
15249509
Eur Heart J. 2007 May;28(10):1221-7
17470670
Am J Cardiol. 1983 Sep 1;52(5):490-4
6193700
Am J Respir Crit Care Med. 2006 Apr 15;173(8):910-6
16424443
Chest. 1991 Oct;100(4):894-902
1914603
Am J Med Sci. 2001 Apr;321(4):225-36
11307864
Hypertension. 2000 Jan;35(1 Pt 1):144-7
10642289
Am J Cardiol. 2000 Sep 15;86(6):688-92, A9
10980227
Sleep. 2008 Sep;31(9):1207-13
18788645
Am Heart J. 1988 Apr;115(4):869-75
3354416
J Appl Physiol (1985). 2009 Jul;107(1):17-24
19228987
Lancet. 2005 Mar 19-25;365(9464):1046-53
15781100
Curr Hypertens Rep. 1999 Feb-Mar;1(1):102-8
10981049
Cardiology. 2005;104(2):92-6
16015032
N Engl J Med. 1993 Apr 29;328(17):1230-5
8464434
Am J Hypertens. 1997 May;10(5 Pt 2):49S-55S
9160781
JAMA. 2000 Apr 12;283(14):1829-36
10770144
Am J Med. 2007 Mar;120(3 Suppl 1):S12-8
17320517
Chest. 2000 Sep;118(3):580-6
10988175
J Hypertens. 1999 Sep;17(9):1297-300
10489107
J Clin Endocrinol Metab. 2000 Mar;85(3):1151-8
10720054
Circulation. 2005 Feb 8;111(5):614-21
15699282
Circulation. 2003 Jan 7;107(1):68-73
12515745
J Am Coll Cardiol. 2007 Apr 17;49(15):1625-1631
17433953
Lancet. 2006 Aug 19;368(9536):666-78
16920472
J Appl Physiol (1985). 1995 Aug;79(2):455-60
7592202
Chest. 1992 Jun;101(6):1526-32
1600769
Am J Cardiol. 1997 Sep 15;80(6):736-40
9315579
Am J Respir Crit Care Med. 2004 Feb 1;169(3):361-6
14597482
J Clin Invest. 1997 Jan 1;99(1):106-9
9011563
Circulation. 1992 Jun;85(6):2025-33
1534286
Arch Intern Med. 1994 Aug 8;154(15):1705-11
8042887
J Am Coll Cardiol. 2007 Feb 6;49(5):565-71
17276180
Hypertension. 2006 May;47(5):840-5
16585412
Am J Epidemiol. 2004 Sep 15;160(6):521-30
15353412
Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):494-8
1892285
Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39
11991871
Circulation. 1999 Aug 17;100(7):706-12
10449691
J Clin Endocrinol Metab. 2001 Feb;86(2):713-8
11158035
N Engl J Med. 2000 May 11;342(19):1378-84
10805822
Circulation. 2003 May 27;107(20):2589-94
12743002
Am Heart J. 2008 Feb;155(2):310-5
18215602
Am J Respir Crit Care Med. 2002 Oct 1;166(7):965-71
12359655
Ann N Y Acad Sci. 1999 Nov 18;892:91-107
10842655
JAMA. 2004 Nov 24;292(20):2471-7
15562125
Arch Intern Med. 2002 Apr 22;162(8):893-900
11966340
Arch Intern Med. 1987 Oct;147(10):1725-8
2444173
Circulation. 2005 Oct 25;112(17):2660-7
16246965
Circulation. 2007 Feb 27;115(8):1020-8
17283257
Am Heart J. 2003 Nov;146(5):902-7
14597942
Chest. 1987 Dec;92(6):1042-6
2960499
Am J Respir Crit Care Med. 2002 Mar 1;165(5):670-6
11874812
Circulation. 2001 Dec 18;104(25):3052-6
11748099
Am J Hypertens. 2003 Apr;16(4):274-80
12670743
Circulation. 1998 Mar 24;97(11):1029-36
9531248
Am J Respir Crit Care Med. 2008 May 15;177(10):1150-5
18276938
Circulation. 1999 Dec 7;100(23):2332-5
10587337
Am J Cardiol. 2007 May 1;99(9):1298-302
17478161
Circulation. 1983 May;67(5):968-77
6219830
Eur Respir J. 2006 Jun;27(6):1229-35
16455835
J Appl Physiol (1985). 2000 Mar;88(3):1084-92
10710407
JAMA. 2001 May 16;285(19):2486-97
11368702
Circulation. 2007 Jul 3;116(1):39-48
17576866
Hypertension. 2007 Aug;50(2):417-23
17548722
N Engl J Med. 2002 Aug 1;347(5):305-13
12151467
Circulation. 1997 Oct 21;96(8):2520-5
9355888
Curr Hypertens Rep. 2002 Apr;4(2):160-6
11884272
Thorax. 2002 May;57(5):429-34
11978920
N Engl J Med. 2003 Mar 27;348(13):1233-41
12660387
J Mol Med (Berl). 2001;79(1):21-9
11327100
Am J Cardiol. 2007 Nov 1;100(9):1460-4
17950808
Lancet. 2005 Apr 16-22;365(9468):1415-28
15836891
Ann Intern Med. 2001 Jun 5;134(11):1015-23
11388814
Arch Intern Med. 2005 Nov 14;165(20):2408-13
16287771
J Clin Invest. 1995 Oct;96(4):1897-904
7560081
Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H234-7
10899061
Arch Intern Med. 2007 Apr 23;167(8):757-64
17452537
J Appl Physiol (1985). 1992 Feb;72(2):583-9
1559936
JAMA. 2000 Dec 20;284(23):3015-21
11122588
Chest. 1995 Sep;108(3):625-30
7656607
Circulation. 2006 Feb 14;113(6):898-918
16380542
Arch Intern Med. 1997 Aug 11-25;157(15):1746-52
9250236
Lancet. 2002 Jan 19;359(9302):204-10
11812555
Ann Intern Med. 1985 Dec;103(6 ( Pt 1)):850-5
3933396
Int J Obes Relat Metab Disord. 1993 Sep;17(9):533-40
8220656
J Intern Med. 1997 Jan;241(1):11-8
9042088
Am J Respir Crit Care Med. 2006 May 15;173(10):1170-5
16514115