title: The effect of fibromyalgia and widespread pain on the clinically significant temporomandibular muscle and joint pain disorders--a prospective 18-month cohort study.
abstract: Although most cases of temporomandibular muscle and joint disorders (TMJD) are mild and self-limiting, about 10% of TMJD patients develop severe disorders associated with chronic pain and disability. It has been suggested that fibromyalgia and widespread pain play a significant role in TMJD chronicity. This paper assessed the effects of fibromyalgia and widespread pain on clinically significant TMJD pain (GCPS II-IV). Four hundred eighty-five participants recruited from the Minneapolis/St. Paul area through media advertisements and local dentists received examinations and completed the Graded Chronic Pain Scale (GCPS) at baseline and at 18 months. Baseline widespread pain (OR: 2.53, P = .04) and depression (OR: 5.30, P = .005) were associated with onset of clinically significant pain (GCPS II-IV) within 18 months after baseline. The risk associated with baseline fibromyalgia was moderate, but not significant (OR: 2.74, P = .09). Persistence of clinically significant pain was related to fibromyalgia (OR: 2.48, P = .02) and depression (OR: 2.48, P = .02). These results indicate that these centrally generated pain conditions play a role in the onset and persistence of clinically significant TMJD.
  
  
  CONCLUSIONS
  Fibromyalgia and widespread pain should receive important consideration when evaluating and developing a treatment plan for patients with TMJD.
authors.affiliation: Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. velly001@umn.edu
authors.forename: Ana Miriam
authors.initials: AM
authors.lastname: Velly
authors.forename: John O
authors.initials: JO
authors.lastname: Look
authors.forename: Eric
authors.initials: E
authors.lastname: Schiffman
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Lenton
authors.forename: Wenjun
authors.initials: W
authors.lastname: Kang
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Messner
authors.forename: Christina A
authors.initials: CA
authors.lastname: Holcroft
authors.forename: James R
authors.initials: JR
authors.lastname: Fricton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015331:Cohort Studies; D015897:Comorbidity; D020918:Complex Regional Pain Syndromes / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D011446:Prospective Studies; D013705:Temporomandibular Joint Disorders / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D055815:Young Adult
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