title: Trimetazidine exerts protection against increasing current electroshock seizure test in mice.
abstract: Trimetazidine, a novel anti-ischemic agent, is used in the therapy of angina, vertigo and chorioretinal diseases. It has also been examined for its effect on nociception, inflammation and neuroprotection in various animal models. The present study was designed to investigate the effect of trimetazidine on electrically induced seizures in mice. Trimetazidine was administered orally in doses of 5, 10 and 20mg/kg (single dose) to observe its effect on the increasing current electroshock seizure (ICES) test in mice. Trimetazidine in 10 and 20mg/kg doses significantly raised the seizure-threshold current in the ICES test. Further, co-administration of per se ineffective dose of trimetazidine (5mg/kg, p.o.) with sub-anticonvulsant dose of nimodipine (10mg/kg, p.o.) and phenytoin (12.5mg/kg, p.o.) offered significant protection in the ICES test. These results indicate that trimetazidine possesses significant anticonvulsant activity against electro-convulsions in the mice.
authors.affiliation: Department of Pharmacology, University College of Medical Sciences & G.T.B. Hospital, University of Delhi, Delhi 110095, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Jain
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bharal
authors.forename: Pramod Kumari
authors.initials: PK
authors.lastname: Mediratta
authors.forename: Krishna Kishore
authors.initials: KK
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D015220:Calcium Channels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D051379:Mice; D009553:Nimodipine / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014292:Trimetazidine / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D015220:Calcium Channels; D014665:Vasodilator Agents; D009553:Nimodipine; D010672:Phenytoin; D014292:Trimetazidine