title: Neoadjuvant chemotherapy for breast cancer: correlation between the baseline MR imaging findings and responses to therapy.
abstract: OBJECTIVE
  To retrospectively evaluate the magnetic resonance (MR) imaging findings of breast cancer before neoadjuvant chemotherapy (NAC) and to compare findings of chemosensitive breast cancer with those of chemoresistant breast cancer.
  
  
  METHODS
  The MR imaging findings before NAC in 120 women undergoing NAC were reviewed. The MR imaging findings were compared with the pathological findings and responses.
  
  
  RESULTS
  A complete response (pCR) and marked response were achieved in 12 and 35% of 120 breast cancers in 120 women respectively. Breast cancers with a pCR or marked response were classified as chemosensitive breast cancer. The remaining 64 breast cancers (53%) were classified as chemoresistant breast cancer. Large tumour size, a lesion without mass effect, and very high intratumoural signal intensity on T2-weighted MR images were significantly associated with chemoresistant breast cancer. Lesions with mass effect and washout enhancement pattern were significantly associated with chemosensitive breast cancer. Areas with very high intratumoural signal intensity on T2-weighted images corresponded pathologically to areas of intratumoural necrosis.
  
  
  CONCLUSIONS
  Several MR imaging features of breast cancer before NAC can help predict the efficacy of NAC.
authors.affiliation: Breast Imaging and Breast Intervention Section, Shizuoka Cancer Center Hospital, Naga-izumi, Shizuoka, 411-8777, Japan. t.uematsu@scchr.jp
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Uematsu
authors.forename: Masako
authors.initials: M
authors.lastname: Kasami
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yuen
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
references.citation: Breast Cancer. 2008;15(1):5-7
references.pmid: 18224386
references.citation: Breast J. 2006 Mar-Apr;12(2):130-7
references.pmid: 16509837
references.citation: AJR Am J Roentgenol. 2005 Mar;184(3):868-77
references.pmid: 15728611
references.citation: AJR Am J Roentgenol. 2003 Nov;181(5):1275-82
references.pmid: 14573420
references.citation: Cancer Sci. 2009 Oct;100(10):1823-33
references.pmid: 19604245
references.citation: Breast J. 1999 Jan;5(1):13-21
references.pmid: 11348250
references.citation: Breast Cancer Res Treat. 2002 Mar;72(2):145-52
references.pmid: 12038705
references.citation: Cancer. 1993 Apr 15;71(8):2507-14
references.pmid: 8453574
references.citation: AJR Am J Roentgenol. 2002 Nov;179(5):1193-9
references.pmid: 12388497
references.citation: Am J Surg Pathol. 2001 Mar;25(3):331-7
references.pmid: 11224603
references.citation: Eur Radiol. 2004 Aug;14(8):1371-9
references.pmid: 14986052
references.citation: Br J Radiol. 1997 May;70(833):452-8
references.pmid: 9227225
references.citation: Radiology. 2009 Mar;250(3):638-47
references.pmid: 19244039
references.citation: Oncol Rep. 2004 Dec;12(6):1257-62
references.pmid: 15547747
references.citation: Ann Oncol. 2006 Aug;17(8):1228-33
references.pmid: 16740599
references.citation: Ann Oncol. 2006 Sep;17(9):1393-8
references.pmid: 16788001
references.citation: Int J Hyperthermia. 2009;25(6):405-15
references.pmid: 19657852
references.citation: Radiol Med. 2003 Jul-Aug;106(1-2):51-8
references.pmid: 12951551
references.citation: Acad Radiol. 2003 May;10(5):484-90
references.pmid: 12755535
references.citation: Cancer. 2008 Jan 1;112(1):17-26
references.pmid: 18000804
references.citation: Br J Cancer. 1999 Feb;79(5-6):991-5
references.pmid: 10070902
references.citation: Cancer. 1982 Mar 15;49(6):1123-30
references.pmid: 6277457
references.citation: Ann Surg Oncol. 2001 Jul;8(6):549-59
references.pmid: 11456056
references.citation: J Clin Oncol. 2005 Jan 1;23(1):41-8
references.pmid: 15625359
references.citation: Cancer. 1996 Jul 1;78(1):91-100
references.pmid: 8646731