title: Successful revascularization of coronary artery occluded by massive intracoronary thrombi with alteplase and percutaneous coronary intervention.
abstract: A 67-year-old man was admitted to our institution with sudden and persistent chest pain for 3 days. Coronary angiography showed massive thrombotic occlusion of the right coronary artery. The patient received intracoronary thrombolysis with alteplase (recombinant tissue-type plasminogen activator, rt-PA). On repeated angiography, there was marked resolution of intracoronary thrombus. After percutaneous coronary intervention with stent implantation, the final result was complete revascularization of the right coronary artery (TIMI grade 3 distal flow). This case demonstrates that intracoronary rt-PA can result in local thrombus reduction in patients undergoing PCI, especially with a large thrombus burden.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Pusan National University School of Medicine, PNU Yangsan Hospital, Yangsan, Korea.
authors.forename: Jeong Su
authors.initials: JS
authors.lastname: Kim
authors.forename: June Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyung Ha
authors.initials: HH
authors.lastname: Jang
authors.forename: Yong Whan
authors.initials: YW
authors.lastname: Lee
authors.forename: Sung Gook
authors.initials: SG
authors.lastname: Song
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Kook Jin
authors.initials: KJ
authors.lastname: Chun
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D008297:Male; D020127:Recovery of Function; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010959:Tissue Plasminogen Activator