Macrophages as mediators of tumor immunosurveillance.
Tumor immunosurveillance is a well-established mechanism for regulation of tumor growth. In this regard, most studies have focused on the role of T- and NK-cells as the critical immune effector cells. However, macrophages play a major role in the recognition and clearance of foreign, aged, and damaged cells. Macrophage phagocytosis is negatively regulated via the receptor SIRPalpha upon binding to CD47, a ubiquitously expressed protein. We recently showed that CD47 is up-regulated in myeloid leukemia and migrating hematopoietic progenitors, and that the level of protein expression correlates with the ability to evade phagocytosis. These results implicate macrophages in the immunosurveillance of hematopoietic cells and leukemias. The ability of macrophages to phagocytose tumor cells might be exploited therapeutically by blocking the CD47-SIRPalpha interaction.
Jaiswal
Siddhartha
S
Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, USA. sjaiswal@stanford.edu
Chao
Mark P
MP
Majeti
Ravindra
R
Weissman
Irving L
IL
D000818:Animals; D051928:CD47 Antigen / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D010587:Phagocytosis; D015398:Signal Transduction
D051928:CD47 Antigen
Nat Med. 2007 Jan;13(1):54-61
17187072
J Exp Med. 2007 Oct 29;204(11):2719-31
17954568
Cell Stem Cell. 2007 Oct 11;1(4):371-81
18371376
Trends Immunol. 2008 Oct;29(10):464-8
18775673
Cell. 2009 Jul 23;138(2):271-85
19632178
Cell Death Differ. 2007 Oct;14(10):1848-50
17657249
J Cell Biol. 2008 Mar 10;180(5):989-1003
18332220
J Exp Med. 2001 Aug 20;194(4):541-9
11514609
Cell Stem Cell. 2009 Jun 5;4(6):499-502
19497277
Semin Cancer Biol. 2004 Jun;14(3):155-60
15246050
Ann N Y Acad Sci. 2009 Sep;1174:118-21
19769744
JAMA. 2005 Sep 21;294(11):1359-66
16174694
J Exp Med. 1994 Mar 1;179(3):1047-52
8113673
Blood. 2002 Dec 15;100(13):4660-7
12393415
Leuk Res. 2005 Apr;29(4):445-50
15725479
Cell Stem Cell. 2009 Sep 4;5(3):310-9
19733542
Transfusion. 2007 Sep;47(9):1725-32
17725740
Front Biosci. 2007 May 01;12:4298-314
17485376
Science. 2000 Jun 16;288(5473):2051-4
10856220
Nat Immunol. 2007 Dec;8(12):1313-23
17982459
J Cancer Res Clin Oncol. 1982;103(1):31-8
7076715
Oncol Rep. 2007 May;17(5):1189-94
17390064
Hepatology. 1995 Feb;21(2):487-94
7843723
J Biol Chem. 1999 Jan 8;274(2):559-62
9872987
Nature. 2001 Sep 13;413(6852):165-71
11557981
Annu Rev Immunol. 2002;20:825-52
11861619
Cancer Immunol Immunother. 2005 Mar;54(3):187-207
15309328
Leuk Lymphoma. 2005 Dec;46(12):1775-84
16263581
Mol Biol Cell. 2004 Aug;15(8):3950-63
15215311
J Clin Oncol. 2005 Dec 10;23(35):8959-67
16219934
Nat Rev Immunol. 2006 Jun;6(6):457-64
16691243
J Lipid Res. 2005 Jan;46(1):11-20
15548472
Nat Rev Immunol. 2006 Nov;6(11):836-48
17063185
J Cell Sci. 1995 Nov;108 ( Pt 11):3419-25
8586654
Drugs. 2002;62 Suppl 1:1-15
12479591
J Immunol. 2000 Feb 15;164(4):2193-9
10657674
Crit Rev Oncol Hematol. 2002 Nov;44(2):143-61
12413632
Cancer Res. 1987 Dec 15;47(24 Pt 1):6686-91
3119198
Nat Rev Immunol. 2003 Jan;3(1):23-35
12511873
Lancet. 2006 Nov 25;368(9550):1894-907
17126723
Semin Cancer Biol. 2008 Oct;18(5):349-55
18467122
Crit Rev Oncol Hematol. 2008 Apr;66(1):1-9
17913510
Cell. 1990 Jun 1;61(5):759-67
2188735
Hepatology. 1996 May;23(5):1224-31
8621157
Nat Med. 1999 Nov;5(11):1277-84
10545994
J Immunol. 2007 Feb 15;178(4):1975-9
17277099
J Infect Dis. 2005 Nov 1;192(9):1666-71
16206084
Carcinogenesis. 2009 Jul;30(7):1073-81
19468060
Nature. 2002 Jul 11;418(6894):200-3
12110892
Mol Immunol. 2004 Nov;41(11):1109-21
15476922
Nature. 1986 Feb 20-26;319(6055):675-8
3951539
Science. 2001 Nov 30;294(5548):1933-6
11729320
Cancer Res. 1992 Oct 1;52(19):5416-20
1394148
Biochem Biophys Res Commun. 2004 Mar 19;315(4):912-8
14985099
J Exp Med. 1997 Jan 6;185(1):1-11
8996237
Tumour Biol. 2008;29(1):28-34
18497546
Science. 1999 Jul 30;285(5428):727-9
10426993
Hepatology. 1991 Aug;14(2):318-24
1907256
J Clin Invest. 2001 Oct;108(7):957-62
11581295
Nature. 2005 Aug 25;436(7054):1186-90
15995699
Am J Pathol. 2008 Oct;173(4):1100-12
18787106
Br Med J. 1957 Apr 13;1(5023):841-7
13413231
J Biol Chem. 2001 Oct 26;276(43):40156-66
11479293
Nature. 2007 Nov 15;450(7168):435-9
17960135
Trends Cell Biol. 2001 Mar;11(3):130-5
11306274
EMBO J. 2006 Nov 29;25(23):5560-8
17093498
Nature. 2001 Nov 1;414(6859):105-11
11689955
J Clin Invest. 1992 Oct;90(4):1513-22
1383273
Science. 1996 Nov 1;274(5288):795-8
8864123
Cell. 2000 Jan 7;100(1):57-70
10647931
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14016-21
19666525
Cell. 2005 Oct 21;123(2):321-34
16239148
Blood. 1993 Jun 15;81(12):3474-9
8507882
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5062-6
17360380
Cell. 2009 Jul 23;138(2):286-99
19632179
Blood. 2002 Oct 15;100(8):2882-90
12351399
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11784-9
18689689
J Biol Chem. 1996 Jan 5;271(1):21-4
8550562
J Immunol. 2004 Aug 15;173(4):2562-70
15294972
Trends Immunol. 2008 May;29(5):203-6
18394962
Nat Rev Immunol. 2009 Aug;9(8):568-80
19629084
Gynecol Oncol. 2007 Jul;106(1):160-3
17490737
Oncol Rep. 2003 Mar-Apr;10(2):309-13
12579264
Blood. 2001 May 1;97(9):2741-9
11313266