Health-related quality of life among early-stage, non-small cell, lung cancer survivors.
BACKGROUND
Limited data are available about the physical and mental functioning of individuals diagnosed and treated for early-stage lung cancer. To develop post-treatment guidelines and targeted resources for the growing number of lung cancer survivors, clinically relevant information about longer term health-related quality of life (HQOL) is needed. The current study examines lung cancer survivors' HQOL and identifies associations between HQOL and demographic, disease and medical risk factors.


METHODS
A total of 359 individuals diagnosed and surgically treated for stage IA or IB non-small cell lung cancer completed a post-treatment survey via mail or telephone that included the SF-36v2 as well as questions regarding demographic and medical factors. To better understand the impact of lung cancer treatment, we examined age- and gender-adjusted differences in HQOL as compared to a demographically matched sample of older adults, most with a significant smoking history, who participated in a lung cancer screening trial. Risk factors for impairments in HQOL were also identified.


RESULTS
Compared to the screening sample, lung cancer survivors reported lower physical health scores, but did not differ in terms of mental health status. Dyspnea and distressed mood were most associated with HQOL impairments.


CONCLUSIONS
Early-stage lung cancer survivors are likely to experience mild impairment in physical functioning. They may benefit from management of distressed mood and referral to physical activity and pulmonary rehabilitation programs to promote HQOL outcomes.
Ostroff
Jamie S
JS
Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, United States. ostroffj@mskcc.org
Krebs
Paul
P
Coups
Elliot J
EJ
Burkhalter
Jack E
JE
Feinstein
Marc B
MB
Steingart
Richard M
RM
Logue
Amy E
AE
Park
Bernard J
BJ
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011788:Quality of Life; D017741:Survivors
J Surg Res. 2006 May 15;132(2):214-8
16566939
Eur J Cardiothorac Surg. 2008 Jan;33(1):95-8
18006327
Lung Cancer. 2007 Aug;57(2):175-80
17442449
Acta Oncol. 1999;38(6):709-18
10522761
Radiology. 2007 Apr;243(1):239-49
17392256
J Clin Oncol. 2002 Jul 1;20(13):2920-9
12089220
Lung Cancer. 2007 Jul;57(1):118-9
17475363
Chest. 1993 Jun;103(6):1863-72
8404115
J Psychiatr Res. 1975 Nov;12(3):189-98
1202204
Thorax. 2005 Mar;60(3):234-8
15741442
Br Med J (Clin Res Ed). 1986 Feb 1;292(6516):344
3080166
J Thorac Oncol. 2007 Aug;2(8):706-14
17762336
Cancer. 2007 Aug 1;110(3):590-8
17582629
Chest. 2004 Feb;125(2):439-45
14769722
Chest. 2006 Apr;129(4):1088-97
16608961
Ann Thorac Surg. 2007 Aug;84(2):410-6
17643607
Chest. 2002 Jul;122(1):21-30
12114334
Support Care Cancer. 2006 Oct;14(10):988-98
16794811
J Clin Oncol. 2008 Jan 10;26(2):233-41
18086802
Nurs Res. 1985 Sep-Oct;34(5):273-7
3850487
J Natl Cancer Inst. 2003 Sep 3;95(17):1276-99
12953083
Lung Cancer. 2009 Nov;66(2):268-9
19726101
Lung Cancer. 2006 May;52(2):257-60
16529844
Med Care. 2003 May;41(5):582-92
12719681
Eur J Cardiothorac Surg. 2009 Jun;35(6):1070-5; discussion 1075
19286388
Thorax. 2003 Mar;58(3):194-7
12612291
Chest. 1984 Jun;85(6):751-8
6723384