title: Synthesis of (+/-)-eusynstyelamide A.
abstract: The synthesis of (+/-)-eusynstyelamide A has been accomplished in six steps in 13% overall yield from 6-bromoindole, methyl glycidate, and Boc-protected agmatine. If oxygen is carefully excluded from the reaction, the key NaOH-catalyzed aldol dimerization of the alpha-ketoamide proceeded efficiently to give Boc-protected eusynstyelamide A.
authors.affiliation: Department of Chemistry MS 015, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Barykina
authors.forename: Barry B
authors.initials: BB
authors.lastname: Snider
mesh_terms: D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006842:Hydrocarbons, Brominated; D007211:Indoles; C542025:eusynstyelamide A
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