A new population of calretinin-positive cells, presumptively neurons, with polymorphous spines in the mouse forebrain.
An immunohistochemical reaction was used to study the locations of calretinin-positive cells on frontal sections of the anterior part of the mouse cerebral cortex. A previously undescribed population of cells with a characteristic structure was found at the anterior horns of the lateral ventricles. These cells had small (8-10 microm) round bodies giving rise to one and occasionally two nodose processes bearing rare polymorphous spines (PS) and thickenings of irregular shape. The relatively thick primary processes branched into finer processes, which also formed thickenings and spines of different calibers and structures. Calretinin-positive cells with polymorphous spines (CR+PS) were located in the white subcortical matter, in layer VI, and, significantly more rarely, in layer V of the frontal area of the dorsomedial cortex close to the cingulum. In addition, CR+PS cells were present in the rostrodorsal part of the caudate nucleus-putamen complex, in the anterior olfactory nucleus, in the subependymal layer of the dorsolateral angle of the lateral ventricle and, more rarely, in its dorsal wall. In contrast to the situation in mice, CR+PS cells were not present in the brains of other animals (rats, rabbits, cats). CR+PS cells showed no colocalization of calretinin with GABA or other neuronal or glial markers. It is suggested that these cells represent a previously unknown, probably neuronal, type of cell in the mouse forebrain.
Revishchin
A V
AV
Neurogenetics and Developmental Genetics Laboratory, Institute of the Biology of the Gene, Russian Academy of Sciences, Moscow, Russia.
Okhotin
V E
VE
Korochkin
L I
LI
Pavlova
G V
GV
D000818:Animals; D064032:Calbindin 2; D002415:Cats; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011817:Rabbits; D051381:Rats; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013045:Species Specificity
C576511:Calb2 protein, mouse; C576512:Calb2 protein, rat; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G
Int Rev Cytol. 2008;265:55-109
18275886
J Chem Neuroanat. 1997 Dec;14(1):1-19
9498163
Dokl Biol Sci. 2000 May-Jun;372:231-3
10944708
Cereb Cortex. 1997 Jun;7(4):347-58
9177765
J Neurosci. 1997 May 15;17(10):3894-906
9133407
Cereb Cortex. 2003 Mar;13(3):297-307
12571119
Eur J Neurosci. 1998 Dec;10(12):3853-68
9875362
Neurosci Behav Physiol. 2004 Jan;34(1):49-66
15109083
Front Neuroanat. 2008 Mar 28;1:3
18958197