Molecular basis of lysophosphatidic acid-induced NF-κB activation.
PKC, β-arrestin 2, CARMA3, BCL10, MALT1, TRAF6 and MEKK3 are signaling proteins that have a key role in G protein-coupled receptor (GPCR)-mediated activation of nuclear factor-κB (NF-κB) pathway in nonhematopoietic cells in response to lysophosphatidic acid (LPA) stimulation. The PKC, β-arrestin 2, CARMA3-BCL10-MALT1-TRAF6 signalosome, and MEKK3 functions as a link between GPCR signaling and IKK-NF-κB activation. Here we briefly summarize recent progress in the understanding of the molecular and biological functions of these proteins in GPCR-mediated NF-κB activation in nonhematopoietic cells.
Sun
Wenjing
W
Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza-BCM320, 6621 Fannin St., MC 3-3320, Houston, TX 77030, United States
Yang
Jianhua
J
D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D005544:Forecasting; D006801:Humans; D008246:Lysophospholipids / Q000494:pharmacology*; D051379:Mice; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D041681:NIH 3T3 Cells; D011506:Proteins / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction
D008246:Lysophospholipids; D016328:NF-kappa B; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; C032881:lysophosphatidic acid
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