Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii.
Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10ng/ml and 100ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.
Kanaujia
Anil
A
Ranbaxy Research Labs, R&D-III, Gurgaon, Haryana, India. anil.kanaujia@ranbaxy.com
Duggar
Rajeev
R
Pannakal
Steve Thomas
ST
Yadav
Satyapal Singh
SS
Katiyar
Chandra Kant
CK
Bansal
Vinay
V
Anand
S
S
Sujatha
S
S
Lakshmi
B S
BS
D000818:Animals; D031484:Capparis / Q000737:chemistry*; D002460:Cell Line; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000235:genetics; D047348:Hydrolyzable Tannins / Q000302:isolation & purification* / Q000494:pharmacology*; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D018716:Molecular Mimicry; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D010766:Phosphorylation / Q000187:drug effects; D008517:Phytotherapy; D012333:RNA, Messenger / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism
D051275:Glucose Transporter Type 4; D047348:Hydrolyzable Tannins; D055504:Insulin Receptor Substrate Proteins; D012333:RNA, Messenger; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D005947:Glucose