Metoclopramide does not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation.
Landiolol is a new ultra-short-acting beta 1-selective adrenoreceptor antagonist, which is metabolized rapidly by plasma cholinesterase (PCHE). Metoclopramide has been shown to inhibit PCHE in vitro. Therefore, metoclopramide might prolong beta blocking effects of landiolol and spoil its ultimate-short-acting property. Just before induction of anesthesia, gynecological patients were randomly assigned to receive 0.2 mg/0.1 ml/kg landiolol and 2 ml saline (Landiolol group; n = 20), 0.2 mg/0.1 ml/kg landiolol and 10 mg metoclopramide/2 ml solution (Landiolol-M group; n = 20), or 0.1 ml/kg saline and 2 ml saline (Control group; n = 20). Tracheal intubation was performed 3 min after induction of anesthesia. Heart rate and blood pressure were recorded. Landiolol with or without metoclopramide similarly inhibited increase in heart rate after induction of anesthesia and tracheal intubation. However, changes in blood pressure were not affected. Metoclopramide at induction of anesthesia did not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation.
Inoue
Satoki
S
Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. seninoue@naramed-u.ac.jp
Abe
Ryuichi
R
Kawaguchi
Masahiko
M
Kobayashi
Hiroshi
H
Furuya
Hitoshi
H
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D009025:Morpholines; C077049:landiolol; D014508:Urea; D008787:Metoclopramide
Can J Anaesth. 2005 Dec;52(10):1027-34
16326671
Anesth Analg. 2005 Mar;100(3):733-737
15728061
Br J Anaesth. 1999 Apr;82(4):542-5
10472219
Anesth Analg. 2007 Jan;104(1):124-9
17179256
Anesthesiology. 1988 Jan;68(1):124-5
3337365
Chem Pharm Bull (Tokyo). 1992 Jun;40(6):1462-9
1356643
Can J Anaesth. 2005 Mar;52(3):254-7
15753495
Br J Anaesth. 1990 Aug;65(2):220-4
2223340
Eur J Clin Pharmacol. 1997;51(6):467-71
9112061
Can J Anaesth. 1988 Sep;35(5):476-8
3273154
Br J Anaesth. 1999 Nov;83(5):761-71
10690140
Eur J Clin Pharmacol. 1995;48(3-4):225-8
7589045
Anesth Analg. 1996 Mar;82(3):607-11
8623969
Pharmazie. 1992 Jan;47(1):66-7
1608990