title: Additional left atrial septal line does not improve outcome of patients undergoing ablation for long-standing persistent atrial fibrillation.
abstract: OBJECTIVE
  Additional septal linear ablation in patients undergoing ablation of long-standing persistent atrial fibrillation (AF) could be beneficial due to additional extensive atrial tissue ablation and incidental ablation of sites with complex fractionated electrograms. We assessed the long-term outcome of patients after ablation of long-standing persistent AF with an additional left atrial (LA) septal line.
  
  
  METHODS
  Thirty-four patients were included.The patients were randomized into two groups and underwent pulmonary vein (PV) isolation with roof line, mitral isthmus line and coronary sinus ablation. In group I an additional LA septal line was created.
  
  
  RESULTS
  AF converted into atrial tachycardia in 2 patients during septal ablation in group I. In group 2 AF terminated via atrial tachycardia in 3 patients (P = ns). During a mean follow-up of 620 +/- 119 days, 7 (41%) and 8 (47%) patients from group 1 and group 2 were free from recurrences (P = ns). Redo procedures were performed in 5 patients of group 1 and in 5 patients of group 2. For a follow-up of 349 +/- 273 days after the last ablation, Cox's F-test showed a trend of more recurrences in group 1 (P = 0.07).
  
  
  CONCLUSIONS
  In patients with long-standing AF, an additional LA septal linear ablation is not associated with a significantly higher AF termination rate. A septal linear lesion might increase the risk of septal reentrant tachycardias, and is associated with a trend towards a worse outcome.
authors.affiliation: Department of Electrophysiology and Cardiac Pacing, Almazov Federal Heart, Blood and Endocrinology Centre, Saint-Petersburg, Russian Federation. evgenymikhaylov@gmail.com
authors.forename: Evgeny
authors.initials: E
authors.lastname: Mikhaylov
authors.forename: Sergey
authors.initials: S
authors.lastname: Gureev
authors.forename: Tamas
authors.initials: T
authors.lastname: Szili-Torok
authors.forename: Dmitry
authors.initials: D
authors.lastname: Lebedev
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods; D002908:Chronic Disease; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria / Q000503:physiopathology / Q000601:surgery*; D006329:Heart Conduction System / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000503:physiopathology / Q000601:surgery*; D055502:Secondary Prevention; D016896:Treatment Outcome