Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats.
Superoxide dismutase, ascorbic acid, glutathione and uric acid levels were decreased and xanthine oxidase, glutathione-s-transferase activities were increased in alcohol treated (2 g/kg body weight, once daily for 30 days) group. However, treatment with ethanolic extract of ginger (100 mg/kg, 200 mg/kg body weight, po, once daily for 30 days) these parameters came to normalcy showing the antioxidant effect of ginger. The antioxidant compounds of ginger may modulate the oxidative stress parameters. The biochemical findings were supplemented by histopathological examination of the kidney. Severe congestion and degenerative changes in tubules in alcohol treated rats were restored by ginger extract treatment. The results confirm the renal protective effect of ginger in alcohol treated rats.
Shanmugam
K R
KR
Division of Molecular Biology and Exercise Physiology, Department of Zoology, Sri Venkateswara University, Tirupati 517 502, India. krshanmugam@yahoo.co.in
Ramakrishna
C H
CH
Mallikarjuna
K
K
Reddy
K Sathyavelu
KS
D000818:Animals; D000431:Ethanol / Q000494:pharmacology* / Q000633:toxicity; D020939:Zingiber officinale / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D010936:Plant Extracts; D017382:Reactive Oxygen Species; D000431:Ethanol; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D005982:Glutathione Transferase; D005978:Glutathione