title: The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.
abstract: In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
authors.forename: Francesco
authors.initials: F
authors.lastname: Venturoni
authors.forename: Nikzad
authors.initials: N
authors.lastname: Nikbin
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
mesh_terms: D047389:Casein Kinase I / Q000037:antagonists & inhibitors*; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D047428:Protein Kinase Inhibitors; D011724:Pyridazines; D047389:Casein Kinase I