title: Therapeutic efficacy of botulinum toxin in the treatment of urinary incontinence in female dogs.
abstract: Urinary incontinence in animals poses a growing therapeutic problem. Satisfactory results in the treatment of incontinence are not reported despite the wide availability of pharmaceuticals addressing the problem. The growing number of side effects and the need for sustained pharmacotherapy have prompted a search for new treatment methods. The experiment described in this study was performed on 11 bitches with clinical symptoms of urinary incontinence. The dogs underwent cystoscopy during which botulinum toxin solution was injected into the wall of the urinary bladder (50-100 botulinum toxin units were given per animal in 10 injections), causing changes in its innervation. Positive therapeutic effects lasting for 5 months in average were noted in 70% of the treated animals.
authors.affiliation: University of Warmia and Mazury in Olsztyn, Department of Internal Diseases, Faculty of Veterinary Medicine, PL-10-719 Olsztyn, Oczapowskiego 14, Poland. s.lew@uwm.edu.pl
authors.forename: Sylwia
authors.initials: S
authors.lastname: Lew
authors.forename: Mariusz
authors.initials: M
authors.lastname: Majewski
authors.forename: Piotr
authors.initials: P
authors.lastname: Radziszewski
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Kuleta
mesh_terms: D000818:Animals; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D014549:Urinary Incontinence / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins