title: Evaluation of amino acids as chiral ligands for the enantiodifferentiation of carbohydrates by TOCSY NMR.
abstract: The use of natural amino acids as chiral ligands on a triethylbenzene scaffold for the binding and enantiodifferentiation of carbohydrates has resulted in moderate affinity and selectivity values for glucose. Selective 1D TOCSY experiments revealed this as a powerful titration technology surpassing the severe overlapping of receptor and carbohydrate signals in (1)H NMR spectra.
authors.affiliation: Departamento de Quimica Organica, Facultad de Quimica and Unidad de RMN de Biomoleculas Asociada al CSIC, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Trillo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernandez-Megia
authors.forename: Ricardo
authors.initials: R
authors.lastname: Riguera
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D008024:Ligands; D005947:Glucose