title: [The role of AGEs and ROS in atherosclerosis].
abstract: Advanced glycation end products (AGEs) are among the "newcomers" of metabolic research during the last 2-3 decades. Also known as Maillard products, they have belonged to the everyday life of food research for a long time, but their role in the development of diabetes and cardiovascular complications has been suggested only recently. Even though multiple studies have recently dealt with the role of AGEs and their receptors in mediating pathomechanisms, we are still far from understanding them completely and maybe even farther from developing effective therapeutic approaches. Nevertheless, the present article attempts to offer an overview of known associations between AGEs and vascular complications, in order to draw attention to a less known subject--the AGEs--and, maybe, to stimulate further research in this very exciting field.
authors.affiliation: Diabetesklinik, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany. stirban@web.de
authors.forename: Alin
authors.initials: A
authors.lastname: Stirban
mesh_terms: D050197:Atherosclerosis / Q000276:immunology*; D017127:Glycation End Products, Advanced / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species
references.citation: Arterioscler Thromb Vasc Biol. 2004 May;24(5):816-23
references.pmid: 14976002
references.citation: Diabetologia. 2002 Jun;45(6):867-76
references.pmid: 12107731
references.citation: Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9441-5
references.pmid: 7937786
references.citation: Diabetes Care. 2003 May;26(5):1589-96
references.pmid: 12716823
references.citation: Int J Clin Pract Suppl. 2002 Jul;(129):51-8
references.pmid: 12166608
references.citation: Nat Med. 2003 Mar;9(3):294-9
references.pmid: 12592403
references.citation: Diabetes Care. 2005 Oct;28(10):2465-71
references.pmid: 16186281
references.citation: Adv Exp Med Biol. 2005;561:135-56
references.pmid: 16438296
references.citation: Circulation. 2001 Nov 27;104(22):2673-8
references.pmid: 11723017
references.citation: FEBS Lett. 1995 Jul 17;368(2):225-9
references.pmid: 7628610
references.citation: Eur J Pharmacol. 1999 Jul 2;376(1-2):17-22
references.pmid: 10440084
references.citation: Horm Metab Res. 2008 Dec;40(12):896-900
references.pmid: 18792885
references.citation: Diabetes Obes Metab. 2007 May;9(3):233-45
references.pmid: 17391149
references.citation: Diabetes Metab. 2001 Sep;27(4 Pt 1):436-47
references.pmid: 11547217
references.citation: Diabetes Care. 2007 Oct;30(10):2514-6
references.pmid: 17630265
references.citation: N Engl J Med. 2005 Dec 22;353(25):2643-53
references.pmid: 16371630
references.citation: FASEB J. 1999 Jan;13(1):23-30
references.pmid: 9872926
references.citation: Circulation. 2004 Jul 20;110(3):285-91
references.pmid: 15249511
references.citation: Diabete Metab. 1992 Jul-Aug;18(4):264-71
references.pmid: 1459313
references.citation: Diabetes. 2004 Jul;53(7):1813-23
references.pmid: 15220206
references.citation: Diabetes Metab Res Rev. 2002 May-Jun;18(3):224-37
references.pmid: 12112941
references.citation: Diabetologia. 2003 Apr;46(4):556-66
references.pmid: 12739028
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8555-60
references.pmid: 12805564
references.citation: Am J Kidney Dis. 2003 Sep;42(3):532-8
references.pmid: 12955681
references.citation: Clin Sci (Lond). 2005 Jul;109(1):83-95
references.pmid: 15755259
references.citation: Diabetes Care. 1996 Mar;19(3):257-67
references.pmid: 8742574
references.citation: Sleep. 2006 Mar;29(3):329-33
references.pmid: 16553018
references.citation: Diabetes. 2002 Jul;51(7):2082-9
references.pmid: 12086936
references.citation: Science. 1966 Jan 14;151(3707):209-10
references.pmid: 5907911
references.citation: Curr Pharm Des. 2005;11(18):2279-99
references.pmid: 16022668
references.citation: Diabetes Care. 2007 Oct;30(10):2579-82
references.pmid: 17496238
references.citation: N Engl J Med. 2003 Jun 5;348(23):2294-303
references.pmid: 12788993
references.citation: Atherosclerosis. 2000 Jun;150(2):299-308
references.pmid: 10856522
references.citation: Nephrol Dial Transplant. 1996;11 Suppl 5:27-30
references.pmid: 9044303
references.citation: Atherosclerosis. 2003 Jun;168(2):213-20
references.pmid: 12801603
references.citation: Atherosclerosis. 2002 Aug;163(2):303-11
references.pmid: 12052477
references.citation: Proc Natl Acad Sci U S A. 1979 Jan;76(1):333-7
references.pmid: 218198
references.citation: J Am Soc Nephrol. 2003 Mar;14(3):728-31
references.pmid: 12595509
references.citation: Diabetes. 2005 Aug;54(8):2314-9
references.pmid: 16046296
references.citation: J Hypertens. 2005 Aug;23(8):1565-73
references.pmid: 16003184
references.citation: Diabetes. 1991 Mar;40(3):377-84
references.pmid: 1847886
references.citation: Diabetes. 1985 Sep;34(9):938-41
references.pmid: 4029512
references.citation: Diabetes Care. 2006 Sep;29(9):2064-71
references.pmid: 16936154
references.citation: J Clin Invest. 1991 Feb;87(2):432-8
references.pmid: 1991829
references.citation: J Hum Hypertens. 2003 Apr;17(4):265-70
references.pmid: 12692571
references.citation: Ann N Y Acad Sci. 2005 Jun;1043:461-6
references.pmid: 16037267
references.citation: Diabetes. 2003 Nov;52(11):2805-13
references.pmid: 14578300
references.citation: Microvasc Res. 2005 Nov;70(3):137-41
references.pmid: 16271939
references.citation: Ann N Y Acad Sci. 2008 Apr;1126:173-6
references.pmid: 18448812