[A concept of regulating tumor microenvironment immune and normalizing angiogenesis by Chinese medicine drug therapy for supporting zheng-qi to prop up root].
Antiangiogenic therapy can generate a "normalization window" for tumor vasculature. This normalization process prunes immature vessels and improves the integrity and function of the remaining vasculature by enhancing the perivascular cell and basement membrane coverage in tumor, therefor creates a window of opportunity for improved sensitivity to ionizing radiation and the delivery of chemotherapeutic drugs. It provides a rational basis for the combination therapy of traditional Chinese drugs with radiation and perhaps other forms of chemotherapy. Antiangiogenic therapy with the traditional Chinese drug interfering in the the mechanisms of the normalization window in humans maybe harness a new approach to improve the sensitivity of tumors to radio- and chemotherapy.
Xiong
Lu
L
Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing. jackxionglu@163.com
Tian
Shao-xia
SX
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D008517:Phytotherapy / Q000379:methods*; D059016:Tumor Microenvironment
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal