title: Total synthesis of PDE-II by copper-mediated double amination.
abstract: A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, beta-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Okano
authors.forename: Nakako
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tokuyama
mesh_terms: D000586:Amination; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D008024:Ligands; D013302:Streptomyces / Q000737:chemistry
chemical_list: D007211:Indoles; D008024:Ligands; D003300:Copper; C030374:indole