Cerebral sinus thrombosis and heparin-induced thrombocytopenia in a patient with paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria is a rare acquired disorder of clonal hematopoietic stem cells and it is characterized as a hypercoagulable disorder. We report a 36-year-old woman with the rare triad of paroxysmal nocturnal hemoglobinuria, cerebral sinus thrombosis triggered by infection, and rapid-onset heparin-induced thrombocytopenia after resensitization of heparin. This case raises caution for heparin-induced thrombocytopenia in paroxysmal nocturnal hemoglobinuria.
Ishihara-Kawase
Kayoko
K
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences. kkawase@hiroshima-u.ac.jp
Ohtsuki
Toshiho
T
Sugihara
Sayaka
S
Tanaka
Hitomi
H
Nakamura
Takeshi
T
Kimura
Akiro
A
Matsumoto
Masayasu
M
D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000188:drug therapy*; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D008582:Meningitis, Aseptic / Q000150:complications; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D014057:Tomography, X-Ray Computed
D000925:Anticoagulants; D001323:Autoantibodies; D006493:Heparin