title: High fruit intake is associated with a lower risk of future hypertension determined by home blood pressure measurement: the OHASAMA study.
abstract: We investigate associations of fruit and vegetable intake with the risk of future hypertension using home blood pressure in a general population from Ohasama, Japan. We obtained data from 745 residents aged ≥35 years without home hypertension at baseline. Dietary intake was measured using a validated 141-item food frequency questionnaire, and subjects were then divided into quartiles according to the fruit and vegetable intake. Home hypertension was defined as home systolic/diastolic blood pressure of ≥135/85 mm Hg and/or the use of antihypertensive medication. During a 4-year follow-up period, we identified 222 incident cases of home hypertension. After adjustment for all putative confounding factors, the highest quartile of fruit intake was associated with a significantly lower risk of future home hypertension (odds ratio 0.40, 95% confidence interval 0.22-0.74, P=0.004). In conclusion, this study, based on home blood pressure measurement, suggests that higher intake of fruit is associated with a lower risk of future home hypertension.
authors.affiliation: Nutritional Epidemiology Program, National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan. mutsugky@nih.go.jp
authors.forename: M
authors.initials: M
authors.lastname: Tsubota-Utsugi
authors.forename: T
authors.initials: T
authors.lastname: Ohkubo
authors.forename: M
authors.initials: M
authors.lastname: Kikuya
authors.forename: H
authors.initials: H
authors.lastname: Metoki
authors.forename: A
authors.initials: A
authors.lastname: Kurimoto
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Asayama
authors.forename: H
authors.initials: H
authors.lastname: Satoh
authors.forename: Y
authors.initials: Y
authors.lastname: Tsubono
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D018660:Blood Pressure Monitoring, Ambulatory; D015930:Diet Records; D005260:Female; D005500:Follow-Up Studies; D005638:Fruit; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000188:drug therapy / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D014675:Vegetables
chemical_list: D000959:Antihypertensive Agents