title: Integrating clinical trial imaging data resources using service-oriented architecture and grid computing.
abstract: Clinical trials which use imaging typically require data management and workflow integration across several parties. We identify opportunities for all parties involved to realize benefits with a modular interoperability model based on service-oriented architecture and grid computing principles. We discuss middleware products for implementation of this model, and propose caGrid as an ideal candidate due to its healthcare focus; free, open source license; and mature developer tools and support.
authors.affiliation: Biomarker Development/Clinical Imaging, Novartis Institutes for BioMedical Research, Lichtstrasse 35, 4056, Basel, Switzerland. stefan.baumann@novartis.com
authors.forename: Stefan Baumann
authors.initials: SB
authors.lastname: El-Ghatta
authors.forename: Thierry
authors.initials: T
authors.lastname: Cladé
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Snyder
mesh_terms: D002986:Clinical Trials as Topic; D019295:Computational Biology; D003628:Database Management Systems; D003952:Diagnostic Imaging; D006295:Health Resources; D006801:Humans; D033181:Information Dissemination; D020407:Internet; D008490:Medical Informatics; D018511:Systems Integration
references.citation: J Am Med Inform Assoc. 2008 Mar-Apr;15(2):138-49
references.pmid: 18096909
references.citation: Clin Pharmacol Ther. 2008 Jul;84(1):69-74
references.pmid: 18563070