title: Molecular evolution of piRNA and transposon control pathways in Drosophila.
abstract: The mere prevalence and potential mobilization of transposable elements in eukaryotic genomes present challenges at both the organismal and population levels. Not only is transposition able to alter gene function and chromosomal structure, but loss of control over even a single active element in the germline can create an evolutionary dead end. Despite the dangers of coexistence, transposons and their activity have been shown to drive the evolution of gene function, chromosomal organization, and even population dynamics (Kazazian 2004). This implies that organisms have adopted elaborate means to balance both the positive and detrimental consequences of transposon activity. In this chapter, we focus on the fruit fly to explore some of the molecular clues into the long- and short-term adaptation to transposon colonization and persistence within eukaryotic genomes.
authors.affiliation: Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Malone
authors.forename: G J
authors.initials: GJ
authors.lastname: Hannon
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics*; D004330:Drosophila / Q000166:cytology / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D049810:Genetic Speciation; D014644:Genetic Variation; D008297:Male; D008957:Models, Genetic; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D034741:RNA, Small Interfering
references.citation: Genes Dev. 2001 Jan 15;15(2):188-200
references.pmid: 11157775
references.citation: Genetics. 2000 Aug;155(4):1841-54
references.pmid: 10924479
references.citation: Mol Cell. 2008 Sep 26;31(6):785-99
references.pmid: 18922463
references.citation: Cytogenet Genome Res. 2005;110(1-4):215-22
references.pmid: 16093675
references.citation: Nature. 2006 Jul 13;442(7099):203-7
references.pmid: 16751777
references.citation: Cell. 1984 Aug;38(1):153-63
references.pmid: 6088060
references.citation: Science. 2007 May 4;316(5825):744-7
references.pmid: 17446352
references.citation: Genome Res. 2009 Oct;19(10):1776-85
references.pmid: 19541914
references.citation: Cytogenet Genome Res. 2005;110(1-4):160-4
references.pmid: 16093668
references.citation: Development. 1997 Jul;124(14):2789-98
references.pmid: 9226450
references.citation: Science. 2009 Jan 23;323(5913):498-501
references.pmid: 19164747
references.citation: Genetics. 1991 Oct;129(2):501-12
references.pmid: 1660427
references.citation: Cancer Cell Int. 2006 May 02;6:13
references.pmid: 16670018
references.citation: Genetics. 1976 May;83(1):107-23
references.pmid: 817964
references.citation: Genetics. 1977 Aug;86(4):813-33
references.pmid: 17248751
references.citation: Dev Cell. 2005 Jul;9(1):51-62
references.pmid: 15992540
references.citation: Genetics. 1995 Feb;139(2):697-711
references.pmid: 7713426
references.citation: Science. 2002 Sep 13;297(5588):1833-7
references.pmid: 12193640
references.citation: Science. 2006 Nov 24;314(5803):1292-5
references.pmid: 17124320
references.citation: Genetics. 1998 Aug;149(4):1857-66
references.pmid: 9691042
references.citation: Dev Cell. 2003 Aug;5(2):337-50
references.pmid: 12919683
references.citation: Mol Gen Genet. 1981;183(1):123-9
references.pmid: 6276672
references.citation: Science. 2006 Jul 21;313(5785):363-7
references.pmid: 16778019
references.citation: Cell. 2002 Aug 9;110(3):315-25
references.pmid: 12176319
references.citation: Genetics. 2007 Apr;175(4):1615-24
references.pmid: 17277359
references.citation: J Gen Virol. 1997 Sep;78 ( Pt 9):2379-88
references.pmid: 9292028
references.citation: Genes Dev. 1994 Sep 1;8(17):2046-57
references.pmid: 7958877
references.citation: Development. 2000 Feb;127(3):503-14
references.pmid: 10631171
references.citation: Cell. 2007 Mar 23;128(6):1089-103
references.pmid: 17346786
references.citation: Nat Rev Genet. 2007 Apr;8(4):272-85
references.pmid: 17363976
references.citation: Mol Cell Biol. 2005 Oct;25(20):9151-64
references.pmid: 16199890
references.citation: Curr Biol. 2001 Jul 10;11(13):1017-27
references.pmid: 11470406
references.citation: Nature. 2009 Oct 29;461(7268):1296-9
references.pmid: 19812547
references.citation: Science. 1983 Apr 8;220(4593):157-62
references.pmid: 17795801
references.citation: Genome Biol. 2002;3(12):RESEARCH0084
references.pmid: 12537573
references.citation: Cell. 2009 May 1;137(3):509-21
references.pmid: 19395009
references.citation: Nature. 2002 Jul 11;418(6894):244-51
references.pmid: 12110901
references.citation: Cell. 2009 Feb 20;136(4):656-68
references.pmid: 19239887
references.citation: Dev Cell. 2007 Jan;12(1):45-55
references.pmid: 17199040
references.citation: Science. 2009 Dec 11;326(5959):1538-41
references.pmid: 19933102
references.citation: Science. 2004 Mar 12;303(5664):1626-32
references.pmid: 15016989
references.citation: Science. 2006 Jul 21;313(5785):320-4
references.pmid: 16809489
references.citation: Science. 2002 Sep 13;297(5588):1831
references.pmid: 12193644
references.citation: Nat Genet. 2000 Apr;24(4):363-7
references.pmid: 10742098
references.citation: Cell. 2009 Feb 6;136(3):461-72
references.pmid: 19203581
references.citation: Curr Opin Genet Dev. 2004 Apr;14(2):181-7
references.pmid: 15196465
references.citation: Science. 1980 Feb 8;207(4431):606-11
references.pmid: 6766221
references.citation: Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11792-6
references.pmid: 7991537
references.citation: Proc Natl Acad Sci U S A. 1988 Feb;85(4):1141-5
references.pmid: 2829216
references.citation: Science. 2008 Nov 28;322(5906):1387-92
references.pmid: 19039138
references.citation: Nature. 1996 Mar 14;380(6570):157-9
references.pmid: 8600389
references.citation: Genes Dev. 2008 Jun 1;22(11):1501-12
references.pmid: 18519642
references.citation: Proc Natl Acad Sci U S A. 1926 Dec;12(12):687-90
references.pmid: 16587134
references.citation: Cell. 2007 Apr 6;129(1):69-82
references.pmid: 17418787
references.citation: Genetics. 1991 Jun;128(2):319-29
references.pmid: 1649069
references.citation: Genes Dev. 2009 Nov 1;23(21):2478-83
references.pmid: 19884254
references.citation: Science. 2007 Mar 16;315(5818):1587-90
references.pmid: 17322028
references.citation: Proc Natl Acad Sci U S A. 1983 Mar;80(6):1655-9
references.pmid: 6300863
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16325-30
references.pmid: 17056713
references.citation: EMBO J. 1994 Sep 15;13(18):4401-11
references.pmid: 7925283
references.citation: Proc Natl Acad Sci U S A. 1926 Jan;12(1):11-6
references.pmid: 16576949
references.citation: Cell. 2002 Sep 20;110(6):689-99
references.pmid: 12297043
references.citation: Cold Spring Harb Symp Quant Biol. 2006;71:171-80
references.pmid: 17381294
references.citation: Proc Natl Acad Sci U S A. 1950 Jun;36(6):344-55
references.pmid: 15430309
references.citation: Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1285-9
references.pmid: 8108403
references.citation: EMBO J. 2008 Oct 22;27(20):2702-11
references.pmid: 18833190
references.citation: Nature. 2006 Jul 13;442(7099):199-202
references.pmid: 16751776
references.citation: Genes Dev. 2005 Jan 1;19(1):77-89
references.pmid: 15598983
references.citation: Cell. 2009 May 1;137(3):522-35
references.pmid: 19395010
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15965-70
references.pmid: 16247000
references.citation: Genes Dev. 1998 Dec 1;12(23):3715-27
references.pmid: 9851978
references.citation: Science. 2004 Jan 30;303(5658):669-72
references.pmid: 14752161
references.citation: Proc Natl Acad Sci U S A. 1992 May 1;89(9):4018-22
references.pmid: 1315047
references.citation: Cell. 2002 Aug 9;110(3):327-38
references.pmid: 12176320
references.citation: Mol Biol Evol. 2007 Feb;24(2):498-504
references.pmid: 17119009
references.citation: Cell. 2008 Dec 12;135(6):1065-73
references.pmid: 19070577
references.citation: Genes Dev. 2007 Sep 15;21(18):2300-11
references.pmid: 17875665