Anti-mullerian hormone and cumulative pregnancy outcome in in-vitro fertilization.
OBJECTIVE
To evaluate the role of Anti-mullerian hormone (AMH) in predicting cumulative pregnancy outcome during in-vitro fertilization (IVF) treatment.


METHODS
Serum AMH levels on day 6 of ovarian stimulation were taken from 180 women undergoing IVF with or without intracytoplasmic sperm injection (ICSI). The main outcome measures were ongoing pregnancy in the fresh cycle, cumulative ongoing pregnancy and ovarian response.


RESULTS
There was a trend of higher median AMH levels in subjects achieving ongoing pregnancy in the fresh IVF cycle. The median AMH levels were significantly higher in subjects attaining ongoing pregnancy cumulatively and in subjects showing ovarian hyper-response in the stimulated cycle. Areas under the ROC curves were 0.606 and 0.792 for the prediction of cumulative ongoing pregnancy and ovarian hyper-response respectively.


CONCLUSIONS
Serum AMH concentration on day 6 of stimulation was significantly higher in subjects who achieved cumulative ongoing pregnancy in IVF compared to those who did not. Serum AMH is a reasonably good predictor of ovarian hyper-response.
Kini
Suresh
S
Assisted Conception Programme, Royal Infirmary of Edinburgh, Edinburgh, UK. suresh.kini@nhs.net
Li
H W Raymond
HW
Morrell
Dave
D
Pickering
Sue
S
Thong
K Joo
KJ
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
D054304:Anti-Mullerian Hormone
Fertil Steril. 2006 Mar;85(3):592-6
16500324
Hum Reprod. 2006 Aug;21(8):2022-6
16679324
Curr Opin Obstet Gynecol. 2008 Jun;20(3):257-64
18460940
Hum Reprod. 2004 Nov;19(11):2439-41
15319392
Clin Endocrinol (Oxf). 2006 Jun;64(6):603-10
16712660
Fertil Steril. 2004 Nov;82(5):1323-9
15533354
Fertil Steril. 2009 Mar;91(3):705-14
18321493
Hum Reprod. 1997 Jul;12(7):1545-9
9262293
Br J Obstet Gynaecol. 1998 Jan;105(1):107-12
9442172
Hum Reprod. 2003 May;18(5):1062-9
12721185
Hum Reprod. 2009 Sep;24(9):2264-75
19520713
Reprod Biomed Online. 2008 May;16(5):664-70
18492370
Fertil Steril. 2009 Jul;92(1):395.e9-395.e12
19410249
Hum Reprod. 2005 Apr;20(4):915-22
15665015
Ann N Y Acad Sci. 2008 Apr;1127:49-58
18443329
Reprod Biomed Online. 2007 May;14(5):602-10
17509203
Fertil Steril. 2009 Jun;91(6):2616-9
18555223
Hum Reprod. 2007 Jul;22(7):1837-40
17485437
Hum Reprod. 2009 Apr;24(4):867-75
19136673
Br J Obstet Gynaecol. 1994 Nov;101(11):999-1002
7999732
Fertil Steril. 2009 Jan;91(1):226-30
18249391
Hum Reprod. 2003 Feb;18(2):328-32
12571169
Fertil Steril. 2008 Sep;90(3):737-43
17923131
Hum Reprod Update. 2006 Nov-Dec;12(6):685-718
16891297
J Clin Endocrinol Metab. 2006 Oct;91(10):4057-63
16804046
Eur J Obstet Gynecol Reprod Biol. 2004 Jul 1;115 Suppl 1:S106-9
15196727
J Assist Reprod Genet. 2001 Mar;18(3):151-5
11411430
Hum Reprod. 2006 Dec;21(12):3103-7
16923748
Hum Reprod. 2000 Sep;15(9):1937-42
10966990
Fertil Steril. 2007 Jan;87(1):223-6
17081531
Fertil Steril. 2008 Apr;89(4):927-33
17603052
Mol Hum Reprod. 2004 Feb;10(2):77-83
14742691
J Clin Endocrinol Metab. 1996 Feb;81(2):571-6
8636269
Hum Reprod. 2006 Jan;21(1):159-63
16123085
Reproduction. 2006 Jan;131(1):1-9
16388003
Fertil Steril. 2009 Nov;92(5):1586-93
18930213
Hum Reprod. 2007 Sep;22(9):2414-21
17636277