title: The nuclear factor NF-kappaB pathway in inflammation.
abstract: The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
authors.affiliation: Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille, France. lawrence@ciml.univ-mrs.fr
authors.forename: Toby
authors.initials: T
authors.lastname: Lawrence
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016328:NF-kappa B
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