title: Image-guided near infrared spectroscopy using boundary element method: phantom validation.
abstract: Image-guided near infrared spectroscopy (IG-NIRS) can provide high-resolution vascular, metabolic and molecular characterization of localized tissue volumes in-vivo. The approach for IG-NIRS uses hybrid systems where the spatial anatomical structure of tissue obtained from standard imaging modalities (such as MRI) is combined with tissue information from diffuse optical imaging spectroscopy. There is need to optimize these hybrid systems for large-scale clinical trials anticipated in the near future in order to evaluate the feasibility of this technology across a larger population. However, existing computational methods such as the finite element method mesh arbitrary image volumes, which inhibit automation, especially with large numbers of datasets. Circumventing this issue, a boundary element method (BEM) for IG-NIRS systems in 3-D is presented here using only surface rendering and discretization. The process of surface creation and meshing is faster, more reliable, and is easily generated automatically as compared to full volume meshing. The proposed method has been implemented here for multi-spectral non-invasive characterization of tissue. In phantom experiments, 3-D spectral BEM-based spectroscopy recovered the oxygen dissociation curve with mean error of 6.6% and tracked variation in total hemoglobin linearly.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH-03755.
authors.forename: Subhadra
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Colin
authors.initials: C
authors.lastname: Carpenter
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
references.citation: Med Phys. 2008 May;35(5):1682-97
references.pmid: 18561643
references.citation: IEEE Trans Med Imaging. 2001 Mar;20(3):147-63
references.pmid: 11341706
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4014-9
references.pmid: 17360469
references.citation: Opt Lett. 2007 Apr 15;32(8):933-5
references.pmid: 17375158
references.citation: Opt Lett. 2004 Feb 1;29(3):256-8
references.pmid: 14759043
references.citation: Radiology. 2007 May;243(2):350-9
references.pmid: 17400760
references.citation: Phys Med Biol. 2008 Feb 21;53(4):837-59
references.pmid: 18263944
references.citation: Phys Med Biol. 2006 Feb 7;51(3):497-516
references.pmid: 16424578
references.citation: Appl Opt. 2005 Apr 10;44(11):2082-93
references.pmid: 15835357
references.citation: Appl Opt. 2003 Sep 1;42(25):5181-90
references.pmid: 12962399
references.citation: Acad Radiol. 2005 Aug;12(8):925-33
references.pmid: 16023383
references.citation: Radiology. 2005 Oct;237(1):57-66
references.pmid: 16183924
references.citation: Appl Opt. 2003 Jun 1;42(16):3117-28
references.pmid: 12790463
references.citation: Med Phys. 1992 Jul-Aug;19(4):879-88
references.pmid: 1518476
references.citation: Neoplasia. 2000 Jan-Apr;2(1-2):26-40
references.pmid: 10933066
references.citation: J Biomed Opt. 2006 Jul-Aug;11(4):044005
references.pmid: 16965162
references.citation: J Biomed Opt. 2005 Mar-Apr;10(2):024033
references.pmid: 15910106
references.citation: Appl Opt. 2003 Jan 1;42(1):135-45
references.pmid: 12518832
references.citation: Technol Cancer Res Treat. 2005 Oct;4(5):513-26
references.pmid: 16173822
references.citation: J Biomed Opt. 2007 Sep-Oct;12(5):051902
references.pmid: 17994885
references.citation: J Biomed Opt. 2005 Sep-Oct;10(5):051504
references.pmid: 16292948
references.citation: Phys Med Biol. 2005 Jun 21;50(12):2837-58
references.pmid: 15930606
references.citation: Nature. 2008 Apr 3;452(7187):580-9
references.pmid: 18385732
references.citation: Opt Express. 2006 Jun 12;14(12):5394-410
references.pmid: 19516706
references.citation: Appl Opt. 1998 Nov 1;37(31):7419-28
references.pmid: 18301576
references.citation: Appl Opt. 2007 Jun 10;46(17):3628-38
references.pmid: 17514325
references.citation: Med Phys. 2007 Jun;34(6):2085-98
references.pmid: 17654912
references.citation: Appl Opt. 2005 Apr 1;44(10):1858-69
references.pmid: 15813523
references.citation: Med Phys. 2007 Nov;34(11):4545-57
references.pmid: 18072520