Asymmetric Michael addition of aldehydes to nitroalkenes using a primary amino acid lithium salt.
Enantioselective Michael addition of aldehydes to nitroalkenes was successfully carried out by asymmetric catalysis with L-phenylalanine lithium salt, giving gamma-nitroaldehydes in good yields with high enantioselectivity.
Yoshida
Masanori
M
Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, 8, Kita 13-jo Nishi, Kita-ku, 060-8628, Sapporo, Japan. myoshida@eng.hokudai.ac.jp
Sato
Atsushi
A
Hara
Shoji
S
D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D008094:Lithium / Q000737:chemistry*; D012492:Salts / Q000737:chemistry
D000447:Aldehydes; D000475:Alkenes; D000596:Amino Acids; D012492:Salts; D008094:Lithium