title: A secoiridoid with quinone reductase inducing activity from Cortex fraxini.
abstract: A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively.
authors.affiliation: Institute of Pharmaceutical Informatics, School of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus, No. 388 Yuhangtang Road, Hangzhou 310058, PR China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Sun
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Ma
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002460:Cell Line; D004789:Enzyme Activation / Q000187:drug effects*; D031661:Fraxinus / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D039823:Iridoids; D010936:Plant Extracts; C557326:chinensisol; D016660:NAD(P)H Dehydrogenase (Quinone)