Facial expression recognition, fear conditioning, and startle modulation in female subjects with conduct disorder.
BACKGROUND
Recent behavioral and psychophysiological studies have provided converging evidence for emotional dysfunction in conduct disorder (CD). Most of these studies focused on male subjects and little is known about emotional processing in female subjects with CD. Our primary aim was to characterize explicit and implicit aspects of emotion function to determine whether deficits in these processes are present in girls with CD.


METHODS
Female adolescents with CD (n = 25) and control subjects with no history of severe antisocial behavior and no current psychiatric disorder (n = 30) completed tasks measuring facial expression and facial identity recognition, differential autonomic conditioning, and affective modulation of the startle reflex by picture valence.


RESULTS
Compared with control subjects, participants with CD showed impaired recognition of anger and disgust but no differences in facial identity recognition. Impaired sadness recognition was observed in CD participants high in psychopathic traits relative to those lower in psychopathic traits. Participants with CD displayed reduced skin conductance responses to an aversive unconditioned stimulus and impaired autonomic discrimination between the conditioned stimuli, indicating impaired fear conditioning. Participants with CD also showed reduced startle magnitudes across picture valence types, but there were no significant group differences in the pattern of affective modulation.


CONCLUSIONS
Adolescent female subjects with CD exhibited deficits in explicit and implicit tests of emotion function and reduced autonomic responsiveness across different output systems. There were, however, no differences in emotional reactivity. These findings suggest that emotional recognition and learning are impaired in female subjects with CD, consistent with results previously obtained in male subjects with CD.
Fairchild
Graeme
G
Developmental Psychiatry Section, Department of Psychiatry, Cambridge University, Cambridge, UK. gff22@cam.ac.uk
Stobbe
Yvette
Y
van Goozen
Stephanie H M
SH
Calder
Andrew J
AJ
Goodyer
Ian M
IM
D000293:Adolescent; D000704:Analysis of Variance; D016022:Case-Control Studies; D003214:Conditioning, Classical; D019955:Conduct Disorder / Q000503:physiopathology / Q000523:psychology*; D004644:Emotions; D005149:Facial Expression; D005239:Fear; D005260:Female; D006801:Humans; D016555:Matched-Pair Analysis; D021641:Recognition, Psychology / Q000502:physiology; D012016:Reference Values; D013216:Reflex, Startle / Q000502:physiology*; D012938:Social Perception
Biol Psychiatry. 2008 Feb 1;63(3):279-85
17765205
Horm Behav. 2008 Jan;53(1):90-5
17976599
Science. 1995 Aug 25;269(5227):1115-8
7652558
Psychol Bull. 2007 Jan;133(1):149-82
17201574
Dev Psychopathol. 1999 Winter;11(1):101-26
10208358
Neuropsychopharmacology. 2007 Oct;32(10):2190-8
17314917
Am J Psychiatry. 2010 Jan;167(1):56-60
19917592
J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):262-76
16492259
Psychophysiology. 1996 Mar;33(2):103-11
8851238
J Am Acad Child Adolesc Psychiatry. 1993 Nov;32(6):1127-34
8282656
Behav Neurosci. 2006 Feb;120(1):24-39
16492114
J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
9204677
J Am Acad Child Adolesc Psychiatry. 1998 Jun;37(6):594-601
9628079
Philos Trans R Soc Lond B Biol Sci. 2003 Mar 29;358(1431):561-72
12689381
J Abnorm Psychol. 2002 Nov;111(4):610-9
12428774
Am J Psychiatry. 1998 Jul;155(7):862-70
9659848
Psychol Med. 2006 Nov;36(11):1563-9
16893483
Behav Neurosci. 2004 Apr;118(2):429-37
15113270
Psychophysiology. 1994 Jul;31(4):319-30
10690912
J Child Psychol Psychiatry. 2004 May;45(4):884-92
15056318
Psychophysiology. 1997 Jan;34(1):97-107
9009813
Br J Psychiatry. 2006 Sep;189:280-1
16946366
J Abnorm Psychol. 1993 Feb;102(1):82-92
8436703
Child Dev. 1987 Jun;58(3):829-41
3608653
J Abnorm Child Psychol. 2001 Dec;29(6):491-8
11761283
J Abnorm Psychol. 1993 Aug;102(3):453-65
8408958
Behav Sci Law. 2003;21(6):737-70
14696029
Arch Gen Psychiatry. 2005 Jul;62(7):799-805
15997022
J Neurosci. 1995 Oct;15(10):6846-55
7472442
J Am Acad Child Adolesc Psychiatry. 1990 Jul;29(4):611-9
2387797
Neurosci Biobehav Rev. 2008;32(3):454-65
17915324
J Abnorm Psychol. 2006 Nov;115(4):815-20
17100539
Psychol Methods. 2003 Dec;8(4):492-496
14664684
J Neurosci. 1995 Sep;15(9):5879-91
7666173
Brain. 1996 Dec;119 ( Pt 6):1991-2000
9010003
J Abnorm Psychol. 2000 Aug;109(3):373-85
11016107
J Cogn Neurosci. 2001 Aug 15;13(6):721-9
11564317
J Abnorm Psychol. 2000 May;109(2):290-8
10895567
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8448-53
12034876
J Child Psychol Psychiatry. 2009 May;50(5):627-36
19432683
Psychophysiology. 2002 Jul;39(4):505-18
12212643
J Am Acad Child Adolesc Psychiatry. 1991 Nov;30(6):973-81
1757447
Clin Neurophysiol. 2003 Sep;114(9):1557-79
12948786
J Abnorm Psychol. 1988 Nov;97(4):487-91
3204235
Am J Psychiatry. 1987 May;144(5):584-9
3495187
Arch Gen Psychiatry. 2001 Aug;58(8):737-45
11483139
J Abnorm Psychol. 1971 Jun;77(3):223-35
5556930
Emotion. 2002 Dec;2(4):398-411
12899372
J Abnorm Psychol. 1957 Jul;55(1):6-10
13462652
Neuropsychologia. 2002;40(10):1675-89
11992656
Emotion. 2001 Sep;1(3):276-98
12934687