Garlic and hepatic coccidiosis: prophylaxis or treatment?
A study was conducted to investigate the protective and therapeutic effects of crude garlic (Allium sativum) against experimental infection with Eimeria stiedae in rabbits. Forty rabbits were divided into four groups of ten rabbits each: a healthy control group (HC); a challenged-garlic-protected group (CGP) which received a daily dose of 0.5 g/kg body weight (bwt) crude garlic for five successive days before challenge with E. stiedae; a challenged-garlic-treated group (CGT) which was treated with a daily dose of 0.5 g/kg bwt crude garlic for five successive days post-challenge; and an infected control group (IC). The challenge dose was 5 x 10(4) sporulated E. stiedae oocysts per rabbit. Mortality rate, body weight gain, feed conversion ratio and faecal oocyst count were evaluated throughout the experiment. At the end of the experiment, all rabbits were killed and histopathological examination was performed. No mortalities were recorded in the HC and CGP groups, whilst mortality was found to be 20% and 40% in the CGT and IC groups, respectively. CGP rabbits had better body weight gain and lower numbers of oocysts than those in the CGT and IC groups. Hepatic lesions were less severe in the CGP group than in the CGT and IC groups. These results showed that oral administration of crude garlic ameliorated the adverse impacts of hepatic coccidiosis on rabbits when used as a prophylactic, but garlic was less effective as a therapeutic.
Abu-Akkada
Somaia S
SS
Department Pathology and Parasitology, Faculty of Veterinary Medicine, Alexandria University, Edfina, Behera, Egypt. somaia_abuakkada@yahoo.com
Oda
Samah S
SS
Ashmawy
Karam I
KI
D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D004539:Eimeria; D005737:Garlic; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D008517:Phytotherapy / Q000662:veterinary*; D028321:Plant Preparations / Q000627:therapeutic use*; D011817:Rabbits / Q000469:parasitology*
D028321:Plant Preparations
Folia Vet Lat. 1976 Jul-Sep;6(3):201-17
1010500
J Egypt Soc Parasitol. 2007 Dec;37(3):957-68
18383795
Exp Parasitol. 2008 May;119(1):164-72
18321485
Int Immunopharmacol. 2010 Mar;10(3):316-24
20004743
Libyan J Med. 2008 Mar 01;3(1):23-33
21499478
Ann Soc Belg Med Trop. 1994 Mar;74(1):51-9
8024350
Br Vet J. 1947 Jun;103(6):207-13
20249463
Exp Parasitol. 1979 Dec;48(3):407-14
510445
J Ethnopharmacol. 2006 Feb 20;103(3):333-7
16213117
J Parasitol. 1999 Oct;85(5):989-91
10577746
Phytother Res. 2003 Feb;17(2):97-106
12601669
J Am Vet Med Assoc. 2003 Aug 15;223(4):495-500
12930089
Trends Parasitol. 2005 Oct;21(10):462-8
16099722
Vet Parasitol. 2001 Apr 19;96(4):257-63
11267752
Avian Dis. 2005 Mar;49(1):1-8
15839405
Int J Vitam Nutr Res. 1998;68(3):208-13
9637953
Mol Aspects Med. 1993;14(3):199-207
8264334