Molecular mechanisms of complement evasion: learning from staphylococci and meningococci.
The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.
Serruto
Davide
D
Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy.
Rappuoli
Rino
R
Scarselli
Maria
M
Gros
Piet
P
van Strijp
Jos A G
JA
D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D015938:Complement Membrane Attack Complex / Q000276:immunology / Q000378:metabolism; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism*; D003593:Cytoplasm / Q000382:microbiology; D057131:Immune Evasion; D007113:Immunity, Innate; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D009345:Neisseria meningitidis / Q000166:cytology / Q000378:metabolism / Q000472:pathogenicity*; D011487:Protein Conformation; D013211:Staphylococcus aureus / Q000166:cytology / Q000378:metabolism / Q000472:pathogenicity*; D014617:Vacuoles / Q000382:microbiology
D001426:Bacterial Proteins; D015938:Complement Membrane Attack Complex; D008565:Membrane Proteins; D003165:Complement System Proteins
Nature. 2006 Nov 9;444(7116):213-6
17051160
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6194-9
15079085
J Immunol. 2008 Aug 15;181(4):2610-9
18684951
Nature. 2005 Sep 22;437(7058):505-11
16177781
Nat Immunol. 2009 Jul;10(7):728-33
19503104
Proc Natl Acad Sci U S A. 1977 Jul;74(7):2701-5
268620
Nat Immunol. 2007 Apr;8(4):430-7
17351618
J Mol Biol. 1994 Jan 14;235(2):695-708
8289289
J Exp Med. 1972 Apr 1;135(4):1003-8
4111773
J Biol Chem. 2004 Jan 23;279(4):2421-9
14607842
Nat Immunol. 2009 Jul;10(7):721-7
19503103
Lancet. 2007 Jun 30;369(9580):2196-2210
17604802
J Mol Biol. 2007 Mar 16;367(1):224-33
17234210
J Immunol. 1996 Oct 1;157(7):3021-9
8816411
J Exp Med. 2009 Oct 26;206(11):2417-27
19808256
Nat Rev Immunol. 2008 Jan;8(1):48-58
18064050
Mol Cell. 2004 Apr 9;14(1):17-28
15068800
Springer Semin Immunopathol. 1984;7(2-3):163-92
6238433
J Biol Chem. 2008 Jun 20;283(25):17579-93
18434316
Vaccine. 2008 Dec 30;26 Suppl 8:I113-7
19388175
J Exp Med. 2003 Mar 17;197(6):789-99
12642606
Infect Immun. 2010 Feb;78(2):802-9
19933829
J Immunol. 2004 Mar 1;172(5):3111-8
14978117
J Exp Med. 2007 Oct 1;204(10):2461-71
17893203
J Immunol. 2005 May 15;174(10):6299-307
15879129
Neoplasia. 2009 Apr;11(4):333-44
19308288
Mol Microbiol. 2007 Feb;63(3):754-67
17212592
Nat Immunol. 2005 Sep;6(9):920-7
16086019
J Infect Dis. 2008 Jul 1;198(1):125-33
18544012
J Biol Chem. 2000 Nov 24;275(47):37257-63
10967103
PLoS Pathog. 2008 Aug 29;4(8):e1000140
18769718
Annu Rev Microbiol. 1988;42:201-30
3059994
Curr Top Microbiol Immunol. 2007;315:477-509
17848076
J Immunol. 2006 Jun 15;176(12):7566-75
16751403
J Immunol. 2006 Jul 1;177(1):501-10
16785547
Hoppe Seylers Z Physiol Chem. 1980 Sep;361(9):1389-99
7439885
J Immunol. 1995 Jul 1;155(1):348-56
7541419
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3681-6
20133685
Nature. 2006 Nov 9;444(7116):217-20
17051150
Adv Exp Med Biol. 2009;666:32-48
20054973
J Exp Med. 2007 Oct 1;204(10):2277-83
17893204
J Biol Chem. 2009 Mar 27;284(13):8738-46
19103601
N Engl J Med. 2001 Apr 12;344(15):1140-4
11297706
J Immunol. 2007 Sep 1;179(5):2989-98
17709514
J Biol Chem. 2006 Mar 17;281(11):7220-7
16407174
Vaccine. 2008 Dec 30;26 Suppl 8:I46-8
19388164
Microbiology (Reading). 2009 Mar;155(Pt 3):667-679
19246738
N Engl J Med. 2001 Apr 5;344(14):1058-66
11287977
Mol Immunol. 2010 Jan;47(4):932-8
19913916
Infect Immun. 2004 Apr;72(4):2088-100
15039331
Pediatr Infect Dis J. 2006 Mar;25(3):255-6
16511390
Proc Natl Acad Sci U S A. 1988 Mar;85(5):1657-61
2964038
Infect Immun. 2010 Apr;78(4):1717-27
20100856
Infect Immun. 2009 Feb;77(2):764-9
19047406
Science. 1998 May 22;280(5367):1277-81
9596584
Lancet Infect Dis. 2009 Jul;9(7):418-27
19555901
Nat Rev Microbiol. 2008 Feb;6(2):132-42
18197169
Blood. 2007 Apr 1;109(7):2936-43
17132726
J Immunol. 2010 Jan 1;184(1):420-5
19949103
Mol Immunol. 2007 Sep;44(16):3875-88
17768106
J Immunol. 2009 Dec 1;183(11):7347-51
19890040
J Exp Med. 1967 Feb 1;125(2):359-80
6019133
Protein Sci. 1997 Feb;6(2):263-74
9041627
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):882-7
19136636
Trends Microbiol. 2005 Dec;13(12):596-601
16242332
Mol Immunol. 2007 Sep;44(16):3809-22
17768099
J Biol Chem. 2009 Apr 17;284(16):10473-9
19196712
Structure. 2006 Oct;14(10):1587-97
17027507
Proc Natl Acad Sci U S A. 1990 May;87(10):3982-6
1692629
J Biol Chem. 2001 Mar 16;276(11):8427-35
11113124
EMBO J. 2009 Aug 19;28(16):2469-78
19574954
J Biol Chem. 2007 Oct 5;282(40):29241-7
17684013
J Immunol. 2009 Nov 15;183(10):6569-78
19846866
Nature. 2009 Apr 16;458(7240):890-3
19225461
Infect Immun. 2008 Jun;76(6):2568-75
18362128
Immunol Lett. 2008 Jun 30;118(2):152-6
18486240
Nat Med. 2002 Jul;8(7):687-93
12091905
PLoS Pathog. 2008 Dec;4(12):e1000250
19112495
Nucleic Acids Res. 2010 Jun;38(10):3263-74
20150412
J Immunol. 2004 Jun 1;172(11):6994-7001
15153520
Infect Immun. 2009 Jan;77(1):292-9
18852235
J Immunol. 2005 Mar 1;174(5):2926-33
15728504
J Biol Chem. 2007 Oct 12;282(41):30051-61
17699522
Nat Struct Mol Biol. 2007 Mar;14(3):224-8
17310251