title: Rapid response to antipsychotic treatment on psychotic prodrome: implications from a case series.
abstract: The feasible intervention strategy at the prodromal state of psychosis is under debate. We report nine subjects clinically in a putative prodromal state of psychosis who responded to low-dose aripiprazole within the first week of medication. We conjecture that the pathophysiological processes might be easier to modify by antipsychotics in the prodromal state and we believe a short-term low-dose trial of antipsychotic agents is a convenient option for subjects at ultra high risk of psychosis. We urge specific attention to monitor the dissolution of psychotic-like symptoms carefully in order to have a better understanding of the pathogenesis and pharmacotherapy in the inception of psychosis.
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital, No. 7 Chung Shan S. Road, Taipei 10002, Taiwan. chchliu@ntu.edu.tw
authors.forename: Chen-Chung
authors.initials: CC
authors.lastname: Liu
authors.forename: Yi-Han
authors.initials: YH
authors.lastname: Sheu
authors.forename: Szu-Ying
authors.initials: SY
authors.lastname: Wu
authors.forename: Meng-Chuan
authors.initials: MC
authors.lastname: Lai
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D000068180:Aripiprazole; D005260:Female; D006801:Humans; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole