title: Exopolysaccharide synthesized by Lactobacillus reuteri decreases the ability of enterotoxigenic Escherichia coli to bind to porcine erythrocytes.
abstract: This study investigated the therapeutic potential of bacterial polysaccharides by employing a model system based on enteroxigenic Escherichia coli (ETEC)-induced hemagglutination of erythrocytes. Exopolysaccharides produced by strains of Lactobacillus reuteri inhibited ETEC-induced hemagglutination of porcine erythrocytes. No effect was observed for dextran produced from Weissella cibaria and commercially available oligo- and polysaccharides.
authors.affiliation: University of Alberta, Department of Agricultural, Food and Nutritional Science, Edmonton, AB T6G 2P5, Canada.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Wang
authors.forename: Michael G
authors.initials: MG
authors.lastname: Gänzle
authors.forename: Clarissa
authors.initials: C
authors.lastname: Schwab
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D000898:Antibiosis; D001422:Bacterial Adhesion; D054307:Enterotoxigenic Escherichia coli / Q000187:drug effects* / Q000472:pathogenicity; D004912:Erythrocytes / Q000382:microbiology*; D006384:Hemagglutination / Q000187:drug effects; D052200:Limosilactobacillus reuteri / Q000378:metabolism*; D056584:Leuconostocaceae / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D011135:Polysaccharides, Bacterial
references.citation: FEMS Microbiol Lett. 2009 Mar;292(1):33-41
references.pmid: 19222580
references.citation: Lancet. 1976 Mar 20;1(7960):629-31
references.pmid: 55904
references.citation: Biochim Biophys Acta. 1980 Oct 1;632(2):326-35
references.pmid: 6774765
references.citation: New Microbiol. 1994 Apr;17(2):99-110
references.pmid: 8065280
references.citation: Appl Environ Microbiol. 2003 Feb;69(2):945-52
references.pmid: 12571016
references.citation: Appl Environ Microbiol. 2003 Apr;69(4):2073-9
references.pmid: 12676685
references.citation: Appl Microbiol Biotechnol. 2006 Aug;71(6):790-803
references.pmid: 16724190
references.citation: Infect Immun. 1977 Feb;15(2):676-8
references.pmid: 321358
references.citation: J Anim Sci. 1998 Feb;76(2):551-6
references.pmid: 9498365
references.citation: Infect Immun. 1991 Jan;59(1):91-6
references.pmid: 1670931
references.citation: J Gen Microbiol. 1975 Feb;86(2):228-40
references.pmid: 46271
references.citation: Adv Microb Physiol. 1972;8:143-213
references.pmid: 4581483
references.citation: Microbiol Mol Biol Rev. 2006 Mar;70(1):157-76
references.pmid: 16524921
references.citation: Infect Immun. 1990 Oct;58(10):3178-82
references.pmid: 1976112
references.citation: J Nutr. 2002 Oct;132(10):3067-72
references.pmid: 12368397
references.citation: Glycoconj J. 2002 Jan;19(1):5-11
references.pmid: 12652075
references.citation: Infect Immun. 2006 Dec;74(12):6920-8
references.pmid: 16982832
references.citation: J Nutr. 1995 Jun;125(6):1401-12
references.pmid: 7782892
references.citation: Am J Vet Res. 1986 Feb;47(2):213-7
references.pmid: 2869725
references.citation: Infect Immun. 1990 Jun;58(6):1870-8
references.pmid: 1692811
references.citation: Res Vet Sci. 1987 Jul;43(1):122-3
references.pmid: 3306851
references.citation: J Gen Microbiol. 1974 Sep;84(1):135-44
references.pmid: 4612097
references.citation: Mol Microbiol. 1992 Jan;6(2):247-55
references.pmid: 1372075