title: Distinct regulation of Arabidopsis ADP-ribose/NADH pyrophosphohydrolases, AtNUDX6 and 7, in biotic and abiotic stress responses.
abstract: Among Arabidopsis Nudix hydrolases (AtNUDX1~27), AtNUDX6 and AtNUDX7 having ADP-ribose/NADH pyrophosphohydrolase activities have been found to contribute to keeping the energy and redox homeostasis, and/or modulating defense responses against biotic and abiotic stress. Interestingly, AtNUDX6 had an opposite effect to AtNUDX7 on the regulation of immune responses. A comparison of the activities of ADP-ribose/NADH pyrophosphohydrolase among wild-type, knockout (KO)-AtNUDX6, and KO-AtNUDX7 plants revealed AtNUDX7 to contribute more than AtNUDX6 to the total pyrophosphohydrolase activity toward both ADP-ribose and NADH under normal conditions and oxidative stress, while AtNUDX6 accounted for the majority of total NADH pyrophosphohydrolase activity under salicylic acid treatment. These results support the idea that the metabolism of ADP-ribose and/or NADH needs to be finely tuned for accurate regulation of cellular responses to biotic and abiotic stress.
authors.affiliation: Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, Nakamachi, Nara, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Takahisa
authors.initials: T
authors.lastname: Ogawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Shigeoka
references.citation: J Biol Chem. 2005 Jul 1;280(26):25277-83
references.pmid: 15878881
references.citation: EMBO J. 2008 Aug 20;27(16):2214-21
references.pmid: 18650934
references.citation: Plant Cell. 2008 Sep;20(9):2339-56
references.pmid: 18790826
references.citation: Acta Biochim Pol. 2008;55(4):663-71
references.pmid: 19081844
references.citation: Plant Physiol. 2008 Nov;148(3):1412-24
references.pmid: 18815383
references.citation: Plant Physiol. 2007 Sep;145(1):204-15
references.pmid: 17660350
references.citation: Plant J. 2007 Apr;50(2):253-64
references.pmid: 17355437
references.citation: Mol Plant Microbe Interact. 2008 May;21(5):646-57
references.pmid: 18393624
references.citation: Comp Funct Genomics. 2009;:820381
references.pmid: 19590748
references.citation: Cell Mol Life Sci. 2006 Jan;63(2):123-43
references.pmid: 16378245
references.citation: Plant Physiol. 2010 Apr;152(4):2000-12
references.pmid: 20181750
references.citation: Plant Cell. 2006 Apr;18(4):1038-51
references.pmid: 16531493
references.citation: Plant Physiol. 2009 Oct;151(2):741-54
references.pmid: 19656905
references.citation: Plant Physiol. 2009 May;150(1):333-47
references.pmid: 19304930
references.citation: Plant J. 2009 Jan;57(2):289-301
references.pmid: 18798872