Dental tissue regeneration - a mini-review.
BACKGROUND
with today's 21st century technological advancements, it is expected that individuals will either retain their natural teeth or obtain functional tooth replacements throughout their entire life. Modern dental therapies for the replacement of missing teeth largely utilize partial or complete dentures and titanium implants capped with prosthetic crowns. Although these prostheses serve a purpose, they are not equivalent, neither in function nor aesthetics, to natural teeth. Recent progress in dental tissue engineering has lent significant credibility to the concept that biological replacement teeth therapies may soon be available to replace missing teeth.


OBJECTIVE
in this review, we summarize the emerging concepts of whole-tooth replacement strategies, using postnatal dental stem cells (DSCs) and dental tissue engineering approaches.


METHODS
we provide a thorough and extensive review of the literature.


RESULTS
current approaches to achieve clinically relevant biological replacement tooth therapies rely on the cultivation of DSCs capable of relaying odontogenic induction signals, through dental epithelial-mesenchymal cell interactions. DSC expansion and differentiation can be achieved by programming progenitor stem cells to adopt dental lineages, using instructive, bioengineered scaffold materials. Periodontal ligament regeneration in particular has demonstrated significant progress recently, despite the somewhat unpredictable clinical outcomes, with regard to its capacity to augment conventional metallic dental implants and as an important component for whole-tooth tissue engineering. Following recent advances made in DSC and tissue engineering research, various research groups are in the midst of performing 'proof of principle' experiments for whole-tooth regeneration, with associated functional periodontal tissues. This mini-review focuses on recent and promising developments in the fields of pulp and periodontal tissue DSCs that are of particular relevance for dental tissue and whole-tooth regeneration.


CONCLUSIONS
continued advances in the derivation of useable DSC populations and optimally designed scaffold materials unequivocally support the feasibility of dental tissue and whole-tooth tissue engineering.
Yen
A-H
AH
Department of Oral and Maxillofacial Pathology, Division of Craniofacial and Molecular Genetics, Tufts University, Boston, Mass., USA.
Yelick
P C
PC
D053687:Adult Stem Cells / Q000637:transplantation; D000368:Aged; D006801:Humans; D007575:Jaw, Edentulous / Q000628:therapy*; D010519:Periodontium / Q000502:physiology; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014070:Tooth / Q000166:cytology / Q000502:physiology*
J Periodontol. 2005 Sep;76(9):1601-22
16171453
J Prosthet Dent. 2003 May;89(5):427-35
12806317
Cytotechnology. 1991 Sep;7(1):49-53
1367700
Biochem Biophys Res Commun. 2007 Apr 13;355(3):758-63
17321500
Arch Histol Cytol. 2004 Mar;67(1):65-77
15125024
J Prosthodont. 2009 Feb;18(2):116-22
19254301
J Oral Pathol. 1980 Jul;9(4):189-200
6777476
J Dent Res. 2002 Aug;81(8):531-5
12147742
Med Hypotheses. 2009 Jan;72(1):58-61
18829177
J Oral Maxillofac Surg. 2009 Feb;67(2):335-47
19138608
Differentiation. 2007 Feb;75(2):158-65
17316385
Lancet. 2004 Jul 10-16;364(9429):149-55
15246727
Biochem Cell Biol. 1998;76(6):923-38
10392706
Dev Dyn. 2003 Dec;228(4):651-63
14648842
Science. 1998 Nov 6;282(5391):1145-7
9804556
Cell. 2001 May 4;105(3):369-77
11348593
J Endod. 2009 Mar;35(3):321-8
19249588
Pharmacol Res. 2008 Aug;58(2):137-47
18602009
Science. 1997 Apr 4;276(5309):71-4
9082988
Nat Biotechnol. 2008 Jan;26(1):101-6
18059259
Orthod Craniofac Res. 2005 Nov;8(4):292-302
16238610
J Biomed Mater Res A. 2008 Dec 15;87(4):986-93
18257082
Transplantation. 2005 Sep 27;80(6):836-42
16210973
Curr Protoc Stem Cell Biol. 2009 Jan;Chapter 4:Unit 4A.1
19170021
J Periodontol. 1986 Dec;57(12):727-34
3467057
Exp Cell Res. 2000 Jul 10;258(1):33-41
10912785
Orthod Craniofac Res. 2005 Aug;8(3):191-9
16022721
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12
12716973
J Periodontal Res. 1999 Jul;34(5):244-50
10567947
J Cell Biochem. 2000 Jun 6;78(3):391-403
10861838
J Dent Res. 2004 Jul;83(7):518-22
15218039
Arch Oral Biol. 1994 Apr;39(4):271-5
8024490
Leukemia. 1998 Mar;12(3):414-21
9529137
J Dent Res. 2006 May;85(5):416-21
16632753
J Exp Zool B Mol Dev Evol. 2009 Jul 15;312B(5):408-15
19065566
Scand J Dent Res. 1976 Nov;84(6):353-6
1070125
Matrix Biol. 2005 Apr;24(2):155-65
15890265
Science. 1999 Apr 2;284(5411):143-7
10102814
Curr Pharm Des. 2008;14(22):2201-11
18781972
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30
11087820
J Dent Res. 2002 Oct;81(10):695-700
12351668
Nature. 2004 Apr 1;428(6982):487-92
15057821
Community Dent Oral Epidemiol. 2008 Jun;36(3):258-68
18474058
Science. 2000 Feb 25;287(5457):1433-8
10688783
Cell. 2009 Apr 3;137(1):13-7
19345179
Science. 2008 Nov 7;322(5903):949-53
18845712
J Biomed Mater Res A. 2008 Sep 15;86(4):1062-8
18067171
Arch Oral Biol. 1968 Dec;13(12):1399-409
5250213
J Am Geriatr Soc. 2008 Mar;56(3):429-35
18194226
PLoS One. 2006 Dec 20;1:e79
17183711
PLoS One. 2008 Jul 02;3(7):e2611
18596969
Tissue Eng. 2006 Aug;12(8):2069-75
16968149
Arch Oral Biol. 1987;32(2):123-7
3478009
Stem Cells. 2009 Mar;27(3):543-9
19096035
Nat Med. 2000 Nov;6(11):1229-34
11062533
J Bone Miner Res. 2010 May;25(5):1167-78
19888897
Biochem Biophys Res Commun. 2008 Jun 20;371(1):90-3
18407827