Carboplatin plus paclitaxel therapy after docetaxel in men with metastatic castrate resistant prostate cancer.
OBJECTIVE
Docetaxel is considered first-line chemotherapy for patients with metastatic castrate resistant prostate cancer (CRPC). Carboplatin and paclitaxel have demonstrated activity in CRPC but published data are limited regarding use after docetaxel.


METHODS
A retrospective, bi-institutional review was conducted of patients with advanced CRPC treated with carboplatin plus paclitaxel after docetaxel. Therapy was evaluated for tolerability, response, and survival. Endpoints used modified Prostate Cancer Working Group 2 criteria.


RESULTS
Twenty-five patients were identified from February 2000 to March 2008. Median pretreatment PSA was 130.2 ng/ml [range 0.1-2100]. Sites of metastases included bone (88%), lymph nodes (52%), pelvis (32%), lung (28%), and liver (20%). A median 4.5 cycles of docetaxel [range 1-22] were given with a median progression-free survival (PFS) of 12 weeks [range 2-68]. Eighty-eight percent of patients (22/25) were docetaxel-refractory at the initiation of therapy with carboplatin (AUC 4-6) day 1 plus paclitaxel 60-80 mg/m(2) days 1, 8, and 21 recycled every 28 days. Patients received a median of 3.5 cycles [range 1-8] of carboplatin/paclitaxel with a median PFS of 12 weeks [range 2-35]. Sixty-four percent of patients (16/25) achieved ≥ 30% reduction in PSA with a median overall survival of 42 weeks [95% CI 30.6-53.5 weeks]. Grade 3 or 4 adverse hematologic events occurred in 11/25 (44%) patients, with no neutropenic fever or grade 3/4 non-hematologic toxicity.


CONCLUSIONS
Carboplatin/paclitaxel chemotherapy following docetaxel in metastatic CRPC is well tolerated with favorable PSA response rates and survival. This combination is a viable option after progression on docetaxel-based therapy.
Jeske
Stephanie
S
Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY 10065, USA.
Tagawa
Scott T
ST
Olowokure
Olugbenga
O
Selzer
Jodi
J
Giannakakou
Paraskevi
P
Nanus
David M
DM
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D018572:Disease-Free Survival; D000077143:Docetaxel; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D043823:Taxoids / Q000627:therapeutic use
D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017430:Prostate-Specific Antigen; D017239:Paclitaxel