Diffusion tensor imaging of the cingulum bundle in children after traumatic brain injury.
Structural damage to the prefrontal-cingulate network has been implicated in cognitive and neurobehavioral deficits associated with traumatic brain injury (TBI). Forty-six children who had sustained moderate-to-severe TBI and 43 children with extracranial injury were imaged using diffusion tensor imaging (DTI). Decreased fractional anisotropy (FA) and increased apparent diffusion coefficient (ADC) values were found in the cingulum bundles bilaterally in the TBI group. Cingulum ADC was related to frontal lesion volume, injury severity, and injury mechanism. Finally, cingulum DTI parameters were related to cognitive control measures. DTI detects TBI-related injury to the cingulum, which may facilitate advances in assessment and treatment.
Wilde
Elisabeth A
EA
Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas-Houston Medical School, Houston, Texas 77030, USA. ewilde@bcm.edu
Ramos
Marco A
MA
Yallampalli
Ragini
R
Bigler
Erin D
ED
McCauley
Stephen R
SR
Chu
Zili
Z
Wu
Trevor C
TC
Hanten
Gerri
G
Scheibel
Randall S
RS
Li
Xiaoqi
X
Vásquez
Ana C
AC
Hunter
Jill V
JV
Levin
Harvey S
HS
D000293:Adolescent; D016880:Anisotropy; D001930:Brain Injuries / Q000150:complications / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D003072:Cognition Disorders / Q000209:etiology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009483:Neuropsychological Tests; D021641:Recognition, Psychology / Q000502:physiology; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D013223:Statistics as Topic / Q000379:methods
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