Primary localized cutaneous amyloidosis intermingled with papulopustular lesions in a patient with Behçet's disease.
Primary localized cutaneous amyloidosis (PLCA) sometimes shows overlapping with collagen vascular diseases; however, association with Behçet's disease (BD) is rare. We herein report a case of PLCA developing intermingled with papulopustular lesions associated with BD. A 57-year-old woman visited our hospital, complaining of recalcitrant multiple oral aphthae. Further detailed physical examination revealed folliculitis-like small pustules with surrounding erythema on the upper back. Also, she stated past histories of genital ulcers 10 years ago and erythema nodosum on the lower legs 4 years ago. A biopsy specimen from the pustular lesion on the back showed neutrophilic abscess in the epidermis with a number of perivascular inflammatory cells in the upper dermis. Congo-red and Dylon stain revealed amyloid deposition in the papillary dermis. Although association of systemic amyloidosis with BD is occasionally found in the literature, co-occurrence of cutaneous amyloidosis and papulopustular lesions of BD is extremely rare.
Yamamoto
Toshiyuki
T
Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan. toyamade@fmu.ac.jp
Suzuki
Yasuhiro
Y
D028226:Amyloidosis, Familial / Q000150:complications* / Q000473:pathology; D001528:Behcet Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D012393:Rosacea / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012873:Skin Diseases, Genetic / Q000150:complications* / Q000473:pathology
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