title: Hip fracture type: important role of parathyroid hormone (PTH) response to hypovitaminosis D.
abstract: OBJECTIVE
  To investigate whether clinical and laboratory characteristics, including serum 25-hydroxyvitamin D (25(OH) D), PTH and parameters of mineral and bone metabolism, differ by hip fracture (HF) type.
  
  
  METHODS
  We studied prospectively 761 consecutively admitted older patients (mean age 82.3+8.8(SD) years; 74.9% women) with low trauma non-pathological HF. A detailed clinical examination was performed, haematologic, renal, liver and thyroid function tests, serum 25(OH)D, PTH, calcium, phosphate, magnesium, C-reactive protein (CRP) and cardiac troponin I (cTnI) measured. In a subset of 294 patients' markers of bone formation (serum osteocalcin, OC; bone specific alkaline phosphatase, BAP) and bone resorption (urinary deoxypyridinoline, DPD/Cr; N-terminal cross-linked telopeptide of type 1 collagen, NTx/Cr; both corrected to urinary creatinine, Cr) were also measured.
  
  
  RESULTS
  In the trochanteric compared to the cervical group, females were older than males and the prevalence of Parkinson's disease, mean haemoglobin and albumin levels were lower. Incidence and degree of myocardial injury (cTnl rise) and inflammatory reaction (CRP elevation) as well as length of hospital stay, need of institutionalisation or in-hospital mortality were similar in both groups. Hypovitaminosis D (25(OH)D <50 mmol/L) was present in 77.8% of patients with cervical and in 82.1% with trochanteric HF, elevated PTH (>6.8 pmol/L) in 30.2% and 41.3%, respectively. The associations between 25(OH)D, PTH, and parameters of mineral metabolism and bone turnover were site-specific. In multivariate analyses, PTH (both as a continuous or categorical variable) response to hypovitaminosis D was a strong independent predictor of HF type. Coexistence of vitamin D deficiency (25(OH) D< 25 nmol/L) and elevated PTH predicts trochanteric HF while blunted PTH response predicts cervical HF (OR=3.5; 95% CI 1.5-80; p=0.005). PTH response and phosphate status (above or below median level) correctly discriminated HF type in 73.8% of patients with vitamin D deficiency.
  
  
  CONCLUSIONS
  HF type is significantly associated with PTH response to hypovitaminosis D and impaired phosphate homeostasis. We detected only minor differences between two main HF types with regard to a wide range of clinical and routine laboratory variables as well as short-term outcomes.
authors.affiliation: Department of Geriatric Medicine, The Canberra Hospital, ACT, Australia. alex.fisher@act.gov.au
authors.forename: Alexander
authors.initials: A
authors.lastname: Fisher
authors.forename: Wichat
authors.initials: W
authors.lastname: Srikusalanukul
authors.forename: Michael
authors.initials: M
authors.lastname: Davis
authors.forename: Paul
authors.initials: P
authors.lastname: Smith
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D006620:Hip Fractures / Q000145:classification* / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D012044:Regression Analysis; D016896:Treatment Outcome; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy*
chemical_list: D010281:Parathyroid Hormone