Unilateral sacroiliitis associated with systemic isotretinoin treatment.
BACKGROUND
Acne fulminans is the most severe form of inflammatory acne characterized by the acute onset of inflammatory nodules and plaques, most commonly on the chest and the back. The lesions undergo rapid suppuration, leaving ragged hemorrhagic ulcers. Typically, it affects adolescent males with a history of mild to moderate acne. The affected patients often have constitutional symptoms such as fever, malaise, arthralgias, and myalgias. Leukocytosis is commonly associated. Sacroiliitis is reported in 21% of acne fulminans patients in association with arthritis and in a few cases it is reported during isotretinoin treatment, suggesting the drug triggering.


CONCLUSIONS
We report a case of a young male patient in whom the induction of acne fulminans by systemic isotretinoin was associated with unilateral sacroiliitis.
Barbareschi
Mauro
M
Institute of Dermatological Science, University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy. melb@libero.it
Paresce
Erberto
E
Chiaratti
Anna
A
Ferla Lodigiani
Alessandra
A
Clerici
Giovanna
G
Greppi
Franco
F
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D026741:Physical Therapy Modalities; D011859:Radiography; D012446:Sacroiliac Joint
D000893:Anti-Inflammatory Agents; D015474:Isotretinoin