title: Spanish radiobiological pattern of care in lung cancer: a GOECP/SEOR study.
abstract: BACKGROUND
  A survey regarding radiobiological questions in the treatment of lung cancer (LC) was done to study the clinical aspects of radiotherapy in Spain, in order to standardise treatment decisions.
  
  
  METHODS
  From November 2007 to March 2008, a survey was performed among radiation oncologists in Spain specialising in LC treatment via e-mail, which included questions regarding different radiobiological aspects of radiotherapy LC treatment. The extent of the resulting material made it necessary to divide it into two parts; the first is presented in this article. The second, which includes items about alpha/beta-NTCP/TCP values and reirradiation criteria, will be reported elsewhere.
  
  
  RESULTS
  Thirty-one radiation therapists from 29 radiation oncology departments answered the survey. 77.4-93.5% of responders used the basic formula from the linear-quadratic model and/or computer software for radiobiological calculations; 100% used lung (mostly V20, median <30%) and spinal cord constraints (mostly a median of physical maximum dose <45.5 Gy); and 90.3% used heart and oesophagus constraints (very heterogeneous parameters in both organs).
  
  
  CONCLUSIONS
  Radiobiological considerations are clearly present in the planning process of radiotherapy of LC in Spain, with a high coincidence with the literature regarding lung and spinal cord constraints. The heterogeneity shown for oesophagus and heart results demonstrates the need for continuing investigation into the standardisation of clinical, dosimetric and radiobiologic aspects of the treatment of this cancer.
authors.affiliation: Department of Radiation Oncology, Instituto Madrileño de Oncología Unidad Regional de Guadalajara, Guadalajara, Spain. jagonzalez@grupoimo.com
authors.forename: J A
authors.initials: JA
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Chust
authors.forename: R
authors.initials: R
authors.lastname: Delgado
authors.forename: A
authors.initials: A
authors.lastname: Gómez
authors.forename: N
authors.initials: N
authors.lastname: Rodríguez
authors.forename: M J
authors.initials: MJ
authors.lastname: Ruiz
authors.forename: F
authors.initials: F
authors.lastname: Casas
mesh_terms: D003625:Data Collection; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D010818:Practice Patterns, Physicians' / Q000592:standards* / Q000706:statistics & numerical data*; D018787:Radiation Oncology / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data*; D013030:Spain
references.citation: Int J Radiat Oncol Biol Phys. 1999 Sep 1;45(2):323-9
references.pmid: 10487552
references.citation: Int J Radiat Oncol Biol Phys. 2003 May 1;56(1):106-13
references.pmid: 12694828
references.citation: Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1075-86
references.pmid: 16647222
references.citation: Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):110-5
references.pmid: 12504042
references.citation: Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):342-9
references.pmid: 17531398
references.citation: Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):100-7
references.pmid: 16839700
references.citation: Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):109-22
references.pmid: 2032882
references.citation: Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):810-7
references.pmid: 18755556
references.citation: Int J Radiat Oncol Biol Phys. 2003 Feb 1;55(2):337-41
references.pmid: 12527046
references.citation: Clin Chem. 2003 Feb;49(2):248-52
references.pmid: 12560347
references.citation: Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1093-112
references.pmid: 7677836
references.citation: Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3):626-9
references.pmid: 15936536
references.citation: Semin Radiat Oncol. 1999 Apr;9(2 Suppl 1):90-6
references.pmid: 10210546
references.citation: Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):155-61
references.pmid: 9422572
references.citation: Radiother Oncol. 1997 Jul;44(1):17-22
references.pmid: 9288852
references.citation: Radiology. 2005 Apr;235(1):208-15
references.pmid: 15703313
references.citation: Int J Radiat Oncol Biol Phys. 1995 Jan 15;31(2):267-72
references.pmid: 7836079
references.citation: Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1399-407
references.pmid: 16997503
references.citation: Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):318-28
references.pmid: 15667949
references.citation: Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1317-22
references.pmid: 14630268
references.citation: Radiother Oncol. 2004 May;71(2):127-38
references.pmid: 15110445
references.citation: Int J Radiat Oncol Biol Phys. 2001 Nov 1;51(3):650-9
references.pmid: 11597805
references.citation: Int J Radiat Oncol Biol Phys. 2003 Mar 1;55(3):724-35
references.pmid: 12573760
references.citation: Strahlenther Onkol. 2003 Aug;179(8):548-56
references.pmid: 14509954
references.citation: Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):995-1002
references.pmid: 15990000
references.citation: Clin Transl Oncol. 2007 Jun;9(6):345-6
references.pmid: 17594947
references.citation: Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1106-13
references.pmid: 15001251
references.citation: Am J Clin Oncol. 2007 Jun;30(3):239-44
references.pmid: 17551299
references.citation: Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):138-42
references.pmid: 16618576
references.citation: Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):291-5
references.pmid: 11567801
references.citation: J Clin Oncol. 2008 Jul 20;26(21):3552-9
references.pmid: 18506026
references.citation: Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):335-47
references.pmid: 15667951
references.citation: Br J Radiol. 1989 Aug;62(740):679-94
references.pmid: 2670032
references.citation: Semin Radiat Oncol. 2007 Apr;17(2):108-20
references.pmid: 17395041
references.citation: Br J Radiol. 1948 Sep;21(249):464-9
references.pmid: 18878308
references.citation: Int J Radiat Oncol Biol Phys. 1999 Aug 1;45(1):97-103
references.pmid: 10477012