title: Successful treatment of multidrug-resistant Acinetobacter baumannii ventriculitis with intrathecal and intravenous colistin.
abstract: Acinetobacter baumannii (AB) nosocomial infections, especially those due to multi-drug resistant (MDR) strains, are increasingly detected. We report a case of a 42-year-old male patient affected by low-grade ependymoma who developed AB-MDR post-neurosurgical ventriculitis. Initially, because of in vitro susceptibility, we used a combination of intravenous colistin and tigecycline. This treatment resulted in the improvement of the patient's initial condition. However, soon after, the infection relapsed; tigecycline was stopped and treatment with intrathecal colistin was initiated. Cure was achieved by continuing this treatment for approximately three weeks, without adverse effects.
authors.affiliation: Institute of Infectious Diseases, Catholic University School of Medicine, Rome, Italy. gennaro.depascale@email.it
authors.forename: G
authors.initials: G
authors.lastname: De Pascale
authors.forename: A
authors.initials: A
authors.lastname: Pompucci
authors.forename: R
authors.initials: R
authors.lastname: Maviglia
authors.forename: T
authors.initials: T
authors.lastname: Spanu
authors.forename: G
authors.initials: G
authors.lastname: Bello
authors.forename: A
authors.initials: A
authors.lastname: Mangiola
authors.forename: G
authors.initials: G
authors.lastname: Scoppettuolo
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000473:pathology; D040981:Acinetobacter baumannii; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000601:surgery; D058565:Cerebral Ventriculitis / Q000188:drug therapy* / Q000473:pathology; D003091:Colistin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004806:Ependymoma / Q000601:surgery; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin