title: Thrombolysis in right versus left hemispheric stroke.
abstract: BACKGROUND
  Recent evidence has suggested that patients with right hemispheric stroke (RHS) present later to an emergency department, have a lower chance to receive intravenous (IV) recombinant tissue plasminogen activator (t-PA), and have poorer clinical outcomes than do patients with left hemispheric stroke (LHS).
  
  
  METHODS
  We analyzed the rate of IV t-PA administration with respect to the side of the affected hemisphere in a large community population, to determine whether a difference exists. The study population was a large prospective cohort of patients with acute stroke treated with IV t-PA at our hospital's stroke center (October 2000 to October 2006).
  
  
  RESULTS
  Of 2,932 patients presenting with ischemic stroke, 953 met criteria for study inclusion. In all, 151 patients received IV t-PA. Between groups, there was no significant difference in presentation within 3 hours after acute stroke (P=.180). There was no difference in the use of IV t-PA between patients with RHS and LHS (P=.237).
  
  
  CONCLUSIONS
  There was no difference with respect to affected hemisphere in time to presentation to the emergency department. Furthermore, there was no difference in the rate of IV t-PA administration for patients with RHS versus LHS. This finding is in contrast to previous research on IV t-PA use in hemispheric stroke and may reflect improved recognition of right hemispheric syndromes.
authors.affiliation: Department of Medical Education, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Blondin
authors.forename: Ilene
authors.initials: I
authors.lastname: Staff
authors.forename: Nora
authors.initials: N
authors.lastname: Lee
authors.forename: Louise D
authors.initials: LD
authors.lastname: McCullough
mesh_terms: D016208:Databases, Factual; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007839:Functional Laterality; D006801:Humans; D016015:Logistic Models; D011446:Prospective Studies; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000706:statistics & numerical data*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator