title: Antioxidant intake and risk of endometrial cancer: results from the Nurses' Health Study.
abstract: To investigate the associations between antioxidant intake and risk of endometrial cancer, the authors analyzed data from the prospective Nurses' Health Study. From 1980 to 2006, 669 invasive adenocarcinoma cases were identified over 1.3 million person-years of follow-up. Information on dietary intake was collected in 1980 and updated every 2-4 years. Cox proportional hazard models were used to calculate the multivariate relative risks (RR), controlling for total energy and potential risk factors for endometrial cancer. Overall, the authors found no association between intakes of vitamins A, C, E or carotenoids from foods or supplements and cancer risk. The RR and 95% confidence intervals (CI) for the highest vs. lowest quintiles of vitamins A, C, E and total carotenoids were 1.09 (95% CI: 0.85-1.39), 0.98 (95% CI: 0.76-1.25), 1.07 (95% CI: 0.83-1.38) and 1.12 (95% CI: 0.86-1.45), respectively. Similarly, the use of multivitamins or specific vitamins A, C or E supplements was unassociated with risk. In subgroup analyses, several associations seemed to vary by postmenopausal hormone use. Our results suggest that there is no overall association between dietary antioxidant intake or use of antioxidant supplements with risk of endometrial cancer.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. nhxxc@channing.harvard.edu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Cui
authors.forename: Bernard
authors.initials: B
authors.lastname: Rosner
authors.forename: Walter C
authors.initials: WC
authors.lastname: Willett
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009726:Nurses; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
chemical_list: D000975:Antioxidants
references.citation: Cancer Res. 2003 May 15;63(10):2483-91
references.pmid: 12750270
references.citation: Am J Epidemiol. 1993 Jan 15;137(2):155-65
references.pmid: 8452119
references.citation: Am J Epidemiol. 1993 Feb 15;137(4):393-403
references.pmid: 8460621
references.citation: Cancer. 1989 Mar 1;63(5):901-6
references.pmid: 2914296
references.citation: Nutr Cancer. 2002;42(1):25-32
references.pmid: 12235647
references.citation: Cancer. 1986 Mar 15;57(6):1248-53
references.pmid: 3002600
references.citation: J Nutr. 2004 Nov;134(11):3143S-3163S
references.pmid: 15514289
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2840-7
references.pmid: 16364998
references.citation: N Engl J Med. 1996 May 2;334(18):1150-5
references.pmid: 8602180
references.citation: Cancer. 1996 Mar 1;77(5):917-23
references.pmid: 8608484
references.citation: J Nutr Biochem. 2007 Sep;18(9):567-79
references.pmid: 17360173
references.citation: Nutr Cancer. 1995;24(3):257-66
references.pmid: 8610045
references.citation: Annu Rev Pharmacol Toxicol. 2004;44:239-67
references.pmid: 14744246
references.citation: Cancer. 1993 Jun 1;71(11):3575-81
references.pmid: 8490907
references.citation: Anal Biochem. 1996 Jul 15;239(1):70-6
references.pmid: 8660627
references.citation: Cancer Causes Control. 2008 Dec;19(10):1209-15
references.pmid: 18592384
references.citation: Eur J Epidemiol. 2000;16(10):899-905
references.pmid: 11338120
references.citation: N Engl J Med. 1996 Aug 29;335(9):640-9
references.pmid: 8692240
references.citation: Int J Cancer. 1999 Mar 15;80(6):827-41
references.pmid: 10074914
references.citation: Int J Gynecol Cancer. 2005 Sep-Oct;15(5):938-45
references.pmid: 16174249
references.citation: Cancer Causes Control. 1993 May;4(3):239-50
references.pmid: 8318640
references.citation: Eur J Cancer. 2007 Nov;43(17):2590-601
references.pmid: 17911009
references.citation: Int J Cancer. 2007 Apr 15;120(8):1776-81
references.pmid: 17230528
references.citation: Am J Epidemiol. 1997 Aug 15;146(4):294-306
references.pmid: 9270408
references.citation: J Cell Physiol. 2008 Jul;216(1):180-8
references.pmid: 18297687
references.citation: N Engl J Med. 1994 Apr 14;330(15):1029-35
references.pmid: 8127329
references.citation: Cancer Control. 2000 May-Jun;7(3):288-96
references.pmid: 10832115
references.citation: J Nutr. 2009 Feb;139(2):317-22
references.pmid: 19074206
references.citation: Ann N Y Acad Sci. 2001 Sep;943:296-315
references.pmid: 11594550
references.citation: Cancer Res. 1997 Nov 15;57(22):5077-85
references.pmid: 9371506
references.citation: Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43
references.pmid: 12496040
references.citation: Cancer Causes Control. 2000 Dec;11(10):965-74
references.pmid: 11142531
references.citation: Lancet. 1994 Sep 24;344(8926):862-3
references.pmid: 7916406
references.citation: Int J Cancer. 2005 May 10;114(6):996-1001
references.pmid: 15645490
references.citation: Br J Cancer. 1996 May;73(10):1284-90
references.pmid: 8630294