Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels.
OBJECTIVE
We have reported that serum glycated albumin (GA) levels are low in obese subjects, smokers and hyperuricemic subjects in whom high sensitive CRP (hs-CRP) is elevated. Because patients with nonalcoholic fatty liver disease with high alanine aminotransferase (ALT) levels are reported to show high levels of hs-CRP, the relationship between serum ALT and serum GA levels was investigated.


METHODS
This study comprised 196 non-diabetic men without drinking habit.


RESULTS
Compared with the normal ALT group (serum ALT < or =30 U/L; n=158), the high ALT group (serum ALT >30 U/L; n=38) had significantly higher fasting plasma glucose (PG), OGTT 2-h PG and HbA(1C) levels. Meanwhile, serum GA was significantly lower, and hs-CRP was significantly higher in the high ALT group.


CONCLUSIONS
The results obtained indicate that serum GA is under a negative control of hs-CRP in subjects with high ALT without drinking habit.
Koga
Masafumi
M
Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. koga_m@kich.itami.hyogo.jp
Murai
Jun
J
Saito
Hiroshi
H
Mukai
Mikio
M
Kasayama
Soji
S
D000410:Alanine Transaminase / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005234:Fatty Liver / Q000097:blood* / Q000201:enzymology / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D033461:Hyperuricemia / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*; D012907:Smoking / Q000097:blood / Q000378:metabolism; D000093423:Glycated Serum Albumin
D000410:Alanine Transaminase; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin