[Secondary osteoporosis UPDATE. Osteomalacia].
Vitamin D related osteomalacia consisted of vitamin D deficient and resistant forms. Vitamin D deficiency was frequently suggested as a complication of osteoporosis. Vitamin D was synthesized in the skin from pro vitamin D by sunlight. And the elderly residents in the nursing home who do not want to come outside frequently are at high risk. Also, the people taking anti-convulsant are the case, because the medications promoted the catabolism of vitamin D through the induction of an enzyme linked to cytochrome P450. Since the effect of bisphosphonate was reported to be decreased in vitamin D deficiency, we have to keep in mind for adding native or active vitamin D for the target people of osteoporosis.
Yamamoto
Takehisa
T
Department of Pediatrics, Minoh City Hospital.
D000927:Anticonvulsants / Q000009:adverse effects; D003577:Cytochrome P-450 Enzyme System; D004164:Diphosphonates / Q000008:administration & dosage; D006801:Humans; D008660:Metabolism; D010018:Osteomalacia / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy; D012306:Risk; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy
D000927:Anticonvulsants; D004164:Diphosphonates; D014807:Vitamin D; D003577:Cytochrome P-450 Enzyme System