Application of polymyxin B convalently immobilized fiber in patients with septic shock.
Sepsis and septic shock are major causes of morbidity and mortality in the intensive care unit. Endotoxin produced by Gram-negative bacteria contributes to the pathogenesis of sepsis and septic shock. As an adsorbent, a polymyxin B convalently immobilized fiber (PMX) was developed. This review discusses, designing of the PMX, its application in clinical practice and the clinical outcomes.
Suzuki
Hiromichi
H
Shoji
Hisataka
H
D000818:Animals; D004731:Endotoxins / Q000097:blood / Q000302:isolation & purification; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D011112:Polymyxin B / Q000008:administration & dosage*; D012772:Shock, Septic / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome
D004731:Endotoxins; D011112:Polymyxin B