Epithelial-to-mesenchymal transitions and circulating tumor cells.
Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.
Bonnomet
Arnaud
A
Laboratory of Tumor and Developmental Biology, Liège University, GIGA - Cancer, C.H.U. Sart-Tilman, Tour de Pathologie B23, 4000 Liège, Belgium.
Brysse
Anne
A
Tachsidis
Anthony
A
Waltham
Mark
M
Thompson
Erik W
EW
Polette
Myriam
M
Gilles
Christine
C
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology*; D054337:Cell Dedifferentiation; D054338:Cell Transdifferentiation; D004847:Epithelial Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000503:physiopathology; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating; D010641:Phenotype
Cell. 2009 Nov 25;139(5):871-90
19945376
J Cell Biochem. 2008 Aug 1;104(5):1587-97
18646053
Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4147-53
16857785
Anticancer Res. 2009 Jun;29(6):2347-55
19528501
Mol Biol Cell. 2006 Mar;17(3):1261-72
16371504
Oncogene. 2005 Mar 31;24(14):2375-85
15674322
Cancer Metastasis Rev. 2009 Jun;28(1-2):15-33
19169796
Cell. 2008 May 16;133(4):704-15
18485877
Mol Cell Biol. 2007 Jan;27(1):157-69
17060462
Cancer Res. 2003 May 1;63(9):2306-11
12727854
Exp Cell Res. 2010 Feb 15;316(4):554-67
20006606
J Pathol. 2006 Mar;208(4):495-506
16429394
Oncogene. 2007 Dec 13;26(57):7859-71
17603561
Hepatology. 2010 Feb;51(2):545-56
19957372
Clin Cancer Res. 2007 Apr 1;13(7):2023-9
17404082
Nat Rev Cancer. 2007 Jun;7(6):415-28
17508028
Cancer Res. 2001 Mar 1;61(5):1890-5
11280743
Nucleic Acids Res. 2005 Nov 24;33(20):6566-78
16314317
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10393-8
12917485
Int J Cancer. 2003 Dec 20;107(6):984-90
14601059
Nat Rev Clin Oncol. 2009 Jun;6(6):339-51
19399023
J Clin Oncol. 2007 Nov 20;25(33):5287-312
17954709
J Clin Invest. 2009 Jun;119(6):1420-8
19487818
Mod Pathol. 2006 Feb;19(2):264-71
16341146
Clin Cancer Res. 2004 Oct 15;10(20):6897-904
15501967
J Cell Sci. 1999 Dec;112 ( Pt 24):4615-25
10574710
Cancer Res. 2008 Mar 1;68(5):1388-97
18316602
Cancer Res. 2003 May 15;63(10):2658-64
12750294
Nat Rev Cancer. 2009 Apr;9(4):302-12
19308069
Cancer Res. 2008 Feb 15;68(4):989-97
18281472
Pathobiology. 2008;75(2):140-8
18544969
Cell. 2003 Jul 11;114(1):33-45
12859896
Int J Cancer. 2006 Jan 1;118(1):35-42
16003740
Cancer Res. 2008 May 15;68(10):3645-54
18483246
Nature. 2002 Jan 31;415(6871):530-6
11823860
Mol Biol Cell. 2005 Sep;16(9):4386-97
15987741
Drug Resist Updat. 2008 Aug-Oct;11(4-5):123-51
18718806
J Mammary Gland Biol Neoplasia. 2009 Mar;14(1):29-43
19242781
Clin Cancer Res. 2007 Feb 1;13(3):920-8
17289886
Clin Exp Metastasis. 2008;25(6):629-42
18461285
Cancer Res. 2005 Sep 1;65(17):7691-8
16140936
J Biol Chem. 2002 Nov 1;277(44):42386-93
12200448
Int J Oncol. 2000 Sep;17(3):573-8
10938400
Clin Exp Metastasis. 2008;25(6):593-600
18286378
Exp Cell Res. 1999 Nov 1;252(2):281-91
10527619
Pathology. 2007 Jun;39(3):305-18
17558857
Clin Cancer Res. 2005 Nov 15;11(22):8070-8
16299238
Nat Rev Clin Oncol. 2009 Apr;6(4):190-1
19333222
Nat Med. 2009 Sep;15(9):1010-2
19734877
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20318-23
19915148
Int J Oncol. 2007 Aug;31(2):277-83
17611683
Mol Cancer Res. 2002 Nov;1(1):68-78
12496370
Oncogene. 2004 Jan 15;23(2):474-82
14724576
Am J Pathol. 1997 Feb;150(2):483-95
9033265
Cell. 2009 Dec 24;139(7):1315-26
20064377
Br J Cancer. 2005 May 23;92(10):1948-52
15841077
Oncogene. 2006 Aug 17;25(36):4975-85
16568083
Cancer Res. 2007 Mar 1;67(5):1979-87
17332325
Nature. 2005 Jul 7;436(7047):123-7
16001073
JAMA. 2010 Mar 17;303(11):1092-3
20233831
Exp Cell Res. 2006 Sep 10;312(15):2860-71
16828470
J Cell Biol. 1997 Jun 16;137(6):1403-19
9182671
Nature. 2006 May 25;441(7092):444-50
16724056
Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4218-24
16857794
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14884-9
19706487
Clin Cancer Res. 2007 Sep 1;13(17):5001-9
17785550
FASEB J. 2002 Apr;16(6):555-64
11919158
J Biol Chem. 2000 Mar 31;275(13):9492-500
10734097
J Cell Sci. 2003 May 15;116(Pt 10):1959-67
12668723
Mol Cell Biol. 2004 Sep;24(17):7559-66
15314165
Cell Biol Int. 2002;26(5):463-76
12095232
Int J Cancer. 2008 Nov 1;123(9):1991-2006
18712708
Cancer Res. 2008 Dec 15;68(24):10377-86
19074907
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13820-5
19666588
Mol Cell Biol. 2009 Jul;29(13):3722-37
19414595
J Cell Physiol. 2007 Nov;213(2):374-83
17680632
Cancer Metastasis Rev. 2007 Jun;26(2):319-31
17458507
Cancer Res. 2006 Jan 1;66(1):46-51
16397214
Cancer Res. 2007 Dec 15;67(24):11721-31
18089802
J Clin Pathol. 2004 Jun;57(6):577-84
15166260
J Biol Chem. 2004 Apr 2;279(14):13564-74
14729679
Cancer Res. 2006 May 15;66(10):5165-72
16707440
Cancer Res. 2005 Jul 15;65(14):5991-5; discussion 5995
16024595
Am J Pathol. 2009 May;174(5):1588-93
19342369
Dev Cell. 2008 Jun;14(6):818-29
18539112
Clin Cancer Res. 2002 Jul;8(7):2073-84
12114406
Cancer Sci. 2010 Feb;101(2):293-9
19961486
Clin Cancer Res. 2006 Mar 15;12(6):1715-20
16551854
Cancer Res. 2001 Aug 15;61(16):6050-4
11507052
Crit Rev Immunol. 2009;29(3):241-54
19538137
J Clin Oncol. 2005 Mar 1;23(7):1420-30
15735118
Breast Cancer Res Treat. 2010 Jul;122(1):211-7
19967556
Cancer Metastasis Rev. 1996 Dec;15(4):507-25
9034607
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):716-28
16469948
Cancer Res. 2009 Sep 15;69(18):7135-9
19738043
J Cell Biochem. 2008 Jun 1;104(3):733-44
18253935
Adv Cancer Res. 2009;102:67-101
19595307
Cells Tissues Organs. 2005;179(1-2):56-65
15942193
Cancer Res. 2006 Dec 1;66(23):11271-8
17145872
Neoplasia. 2009 Dec;11(12):1371-82
20019845
Nat Cell Biol. 2000 Feb;2(2):76-83
10655586
Lung Cancer. 2008 Oct;62(1):8-14
18372076
Cell Cycle. 2008 Oct;7(20):3112-8
18927505
Am J Pathol. 2003 Oct;163(4):1437-47
14507651
Development. 2005 Jul;132(14):3151-61
15983400
Nat Rev Cancer. 2002 Jun;2(6):442-54
12189386
Cancer Res. 2005 Jul 15;65(14):5996-6000; discussion 6000-1
16024596
Cell Mol Life Sci. 2009 Mar;66(5):773-87
19011757
J Exp Clin Cancer Res. 2007 Sep;26(3):385-94
17987801
Breast Cancer Res Treat. 2006 Jul;98(2):179-84
16552629
Br J Cancer. 2000 Dec;83(12):1664-73
11104564
Oncogene. 2008 Feb 21;27(9):1218-30
17724470
Biochem Biophys Res Commun. 2008 May 16;369(4):1098-102
18331824
Breast Cancer Res. 2009;11(4):R46
19589136
Breast Cancer Res. 2001;3(5):289-93
11597316
Cancer Biol Ther. 2009 Apr;8(8):671-5
19242121
Cells Tissues Organs. 2007;185(1-3):7-19
17587803
Clin Transl Oncol. 2008 Dec;10(12):777-85
19068448
J Cell Biol. 2006 Mar 27;172(7):973-81
16567498
Exp Cell Res. 2004 Oct 1;299(2):315-24
15350531
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
11553815
FEBS Lett. 1996 Apr 8;384(1):14-8
8797794
J Cell Sci. 2004 Jun 1;117(Pt 13):2827-39
15169839
Cancer Res. 2009 May 15;69(10):4116-24
19435916
Breast Cancer Res. 2008;10 Suppl 1:S1
19091005
Cancer Res. 2003 Jun 15;63(12):3386-94
12810675
Int J Cancer. 2005 Oct 10;116(6):847-52
15856465
Cancer Cell. 2008 Jul 8;14(1):79-89
18598946
Biochimie. 2005 Mar-Apr;87(3-4):329-42
15781320
Cancer Res. 2008 Jan 15;68(2):537-44
18199550
Br J Cancer. 2005 Mar 14;92(5):906-12
15714202
Nat Cell Biol. 2008 May;10(5):593-601
18376396
J Cell Mol Med. 2009 Sep;13(9B):4002-13
19426156
Cell. 2004 Jun 25;117(7):927-39
15210113
J Natl Cancer Inst. 2008 Feb 20;100(4):232-3, 239
18270330
J Biol Chem. 2008 May 30;283(22):14910-4
18411277
Clin Exp Metastasis. 2008;25(6):591-2
18566898
Cells Tissues Organs. 2007;185(1-3):61-5
17587809
Int J Cancer. 2009 Jun 1;124(11):2568-76
19243022
Cancer Res. 2006 Mar 1;66(5):2778-84
16510599
Nat Rev Cancer. 2009 Apr;9(4):265-73
19262571
Nat Cell Biol. 2008 Mar;10(3):295-305
18297062
Stem Cells. 2009 Sep;27(9):2059-68
19544473
J Cell Sci. 1998 Jul;111 ( Pt 13):1897-907
9625752
Differentiation. 2006 Jun;74(5):254-64
16759291
Curr Opin Genet Dev. 2006 Feb;16(1):51-9
16377174
Cancer Metastasis Rev. 2009 Jun;28(1-2):151-66
19153669
Nat Rev Cancer. 2004 Jun;4(6):448-56
15170447
Mol Cancer Ther. 2009 May;8(5):1055-66
19435871
J Cell Sci. 2003 Feb 1;116(Pt 3):499-511
12508111
Mol Biol Cell. 2009 Apr;20(8):2207-17
19225155
Br J Cancer. 2007 Feb 26;96(4):654-9
17262082
J Cell Sci. 2000 Jul;113 ( Pt 13):2455-62
10852824
J Pathol. 2000 Jan;190(1):15-9
10640987
Genome Biol. 2007;8(5):R76
17493263
Cancer Res. 2006 Sep 1;66(17):8319-26
16951136
Bull Cancer. 2006 Mar 1;93(3):251-6
16567311
Histochem Cell Biol. 2008 Sep;130(3):481-94
18648847
Nat Rev Cancer. 2008 May;8(5):329-40
18404148
Int J Clin Oncol. 2008 Jun;13(3):252-6
18553236
Clin Cancer Res. 2009 Apr 15;15(8):2657-65
19336515