Synthesis and biological evaluation of novel spiro 6-methoxytetralin-1,3'-pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice.
A series of novel organoselenocyanate compounds (6a-d) having spiro[tetralin-1,3'-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium- (Cd) induced toxicity in Swiss Albino mice. All the compounds (6a-d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities, e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds, 6d being the most active one (6d>6c>6b>6a).
Sk
Ugir Hossain
UH
Department of Pharmacology, Chemical Carcinogenesis and Chemoprevention Program of Penn State Hershey Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Sharma
Arun K
AK
Ghosh
Sulekha
S
Bhattacharya
Sudin
S
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D003485:Cyanates / Q000737:chemistry*; D055808:Drug Discovery; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D011759:Pyrrolidines / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry*
D000975:Antioxidants; D015415:Biomarkers; D003485:Cyanates; D016566:Organoselenium Compounds; D011759:Pyrrolidines; D018036:Selenium Compounds; D002104:Cadmium; C053721:selenocyanic acid; D005978:Glutathione