Structure and function of interleukin-22 and other members of the interleukin-10 family.
The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-lambdas (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.
Trivella
Daniela Barretto Barbosa
DB
Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense 400, São Carlos, SP, CEP 13566-590, Brazil.
Ferreira-Júnior
José Ribamar
JR
Dumoutier
Laure
L
Renauld
Jean-Christophe
JC
Polikarpov
Igor
I
D000595:Amino Acid Sequence; D006801:Humans; D016753:Interleukin-10 / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D007378:Interleukins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D055503:Protein Multimerization; D018121:Receptors, Cytokine / Q000378:metabolism*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*; D000097043:Interleukin-22
D016753:Interleukin-10; D007378:Interleukins; D018121:Receptors, Cytokine; D000097043:Interleukin-22
Vitam Horm. 2006;74:77-103
17027512
FEBS Lett. 2008 Sep 3;582(20):2985-92
18675809
Int Immunopharmacol. 2004 May;4(5):609-13
15120646
Vitam Horm. 2006;74:165-206
17027515
Int Immunopharmacol. 2004 May;4(5):593-608
15120645
J Clin Invest. 2008 Feb;118(2):597-607
18202747
Blood. 1997 Nov 15;90(10):4162-71
9354687
Cytokine Growth Factor Rev. 2003 Feb;14(1):35-51
12485618
Immunity. 2008 Dec 19;29(6):947-57
19100701
Int Immunol. 1996 Oct;8(10):1587-94
8921438
J Immunol. 2002 Jun 15;168(12):6041-6
12055212
Immunity. 2001 Jul;15(1):35-46
11485736
J Virol. 2000 Apr;74(8):3881-7
10729163
Structure. 2000 Sep 15;8(9):927-36
10986460
Am J Pathol. 2008 Sep;173(3):901-9
18669613
Physiol Rev. 1999 Jul;79(3):683-701
10390516
Arthritis Rheum. 2009 Feb;60(2):390-5
19180498
Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G960-8
16051921
Bioinformatics. 2007 Nov 1;23(21):2947-8
17846036
J Exp Med. 1989 Dec 1;170(6):2081-95
2531194
Lancet. 2007 Jul 21;370(9583):263-271
17658397
J Immunol. 1995 Nov 1;155(9):4412-8
7594602
J Mol Model. 2004 Aug;10(4):290-6
15243778
J Leukoc Biol. 2008 May;83(5):1181-93
18281438
Nat Rev Immunol. 2003 Aug;3(8):667-76
12974481
Int Immunopharmacol. 2004 May;4(5):615-26
15120647
J Leukoc Biol. 2004 Aug;76(2):314-21
15123776
J Cell Biochem. 1999 Jul 1;74(1):1-10
10381256
Hepatology. 2004 May;39(5):1332-42
15122762
Clin Exp Immunol. 2007 Dec;150(3):407-15
17900301
Eur Cytokine Netw. 2002 Jan-Mar;13(1):5-15
11956016
J Biol Chem. 2004 Jul 30;279(31):32269-74
15166220
J Immunol. 2000 Feb 15;164(4):1814-9
10657629
J Exp Med. 2009 Jul 6;206(7):1465-72
19564350
J Biol Chem. 1991 Nov 15;266(32):21791-7
1939201
Curr Opin Immunol. 2002 Feb;14(1):96-102
11790538
Lymphokine Cytokine Res. 1994 Feb;13(1):47-54
8186324
Autoimmunity. 2008 Aug;41(5):363-71
18568641
Genes Immun. 2005 Feb;6(1):8-18
15526001
J Biol Chem. 2004 Aug 6;279(32):33343-51
15178681
Nat Genet. 2009 Oct;41(10):1100-4
19749758
Brain Behav Immun. 2006 Mar;20(2):175-81
16023829
J Immunol. 2006 Jun 15;176(12):7686-94
16751416
J Immunol. 1994 Feb 15;152(4):1821-9
8120391
J Clin Invest. 2008 Feb;118(2):534-44
18172556
Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10144-9
10954742
Eur J Immunol. 1999 Sep;29(9):2658-65
10508240
Nature. 2009 Sep 17;461(7262):399-401
19684573
Nat Med. 2008 Mar;14(3):275-81
18264110
J Virol. 2007 Jul;81(14):7749-58
17507495
J Immunol. 2010 Feb 15;184(4):1793-8
20061404
Annu Rev Immunol. 2004;22:929-79
15032600
Cell. 2001 Jan 12;104(1):9-19
11163236
Biochem Biophys Res Commun. 2006 Jun 16;344(4):1334-41
16650825
Oncogene. 1995 Dec 21;11(12):2477-86
8545104
Protein Sci. 1996 Oct;5(10):1955-62
8897595
Arthritis Rheum. 2000 Sep;43(9):1976-81
11014347
Gastroenterology. 2006 Dec;131(6):1887-98
17087946
Cytokine Growth Factor Rev. 2006 Oct;17(5):367-80
17030002
Cytokine Growth Factor Rev. 2002 Jun;13(3):223-40
12486876
J Immunol. 2007 Apr 15;178(8):5086-98
17404291
J Biol Chem. 2002 Mar 1;277(9):7341-7
11706020
Science. 2002 Nov 22;298(5598):1630-4
12446913
J Biol Chem. 2003 Jan 31;278(5):3308-13
12403790
J Immunol. 2001 Jun 15;166(12):7090-5
11390453
J Mol Biol. 2004 Sep 10;342(2):503-14
15327950
J Immunol. 2001 Jun 15;166(12):7096-103
11390454
Gut. 2009 Sep;58(9):1207-17
18483078
Mol Ther. 2005 Jan;11(1):4-18
15585401
J Biol Chem. 2008 Oct 31;283(44):30079-89
18757365
J Biol Chem. 2001 Jan 26;276(4):2725-32
11035029
Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50
15983417
Cell Mol Immunol. 2004 Feb;1(1):43-9
16212920
Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9404-9
12093920
Nat Immunol. 2009 Jan;10(1):75-82
19029904
Eur J Immunol. 2005 May;35(5):1576-82
15827959
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9511-6
11481447
J Biol Chem. 2005 Apr 22;280(16):15809-14
15755740
PLoS Pathog. 2008 Sep 12;4(9):e1000151
18787692
J Mol Med (Berl). 2009 May;87(5):523-36
19330474
Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):545-67
11313011
J Interferon Cytokine Res. 2001 Dec;21(12):1047-53
11798462
Biochemistry. 1995 Sep 26;34(38):12118-25
7547951
J Immunol. 2004 Dec 1;173(11):6712-8
15557163
Cytokine. 2006 Jul;35(1-2):44-52
16908179
Eur J Immunol. 2006 May;36(5):1309-23
16619290
Mol Biol Cell. 2006 Jul;17(7):2986-95
16624864
EMBO J. 1997 Oct 1;16(19):5894-903
9312047
Genes Immun. 2000 Dec;1(8):488-94
11197690
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3041-5
7708771
J Virol. 1996 Sep;70(9):6012-9
8709223
Cancer Res. 2005 Nov 15;65(22):10128-38
16287994
Am J Respir Cell Mol Biol. 2004 Aug;31(2):220-6
15039135
Clin Exp Immunol. 2000 May;120(2):375-83
10792391
N Engl J Med. 2001 Mar 22;344(12):907-16
11259725
Biophys J. 2008 Mar 1;94(5):1754-65
18024507
Cancer Res. 2004 May 1;64(9):2988-93
15126330
Mol Ther. 2005 Jan;11(1):149-59
15585416
Annu Rev Immunol. 2001;19:683-765
11244051
Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):23-9
15519673
Immunity. 2004 Aug;21(2):241-54
15308104
Invest New Drugs. 1989 Jul;7(2-3):179-88
2793370
J Biol Chem. 2009 Jul 31;284(31):20869-75
19457860
Adv Protein Chem. 2004;68:171-223
15500862
Bioinformatics. 2009 May 1;25(9):1189-91
19151095
Structure. 2008 Sep 10;16(9):1333-44
18599299
Nature. 2009 Oct 8;461(7265):798-801
19759533
Nature. 2009 Feb 5;457(7230):722-5
18978771
Mol Ther. 2005 Jan;11(1):160-72
15585417
J Exp Med. 2006 Oct 2;203(10):2271-9
16982811
PLoS Pathog. 2008 Mar 14;4(3):e1000017
18369468
J Cell Mol Med. 2008 Dec;12(6A):2505-10
18505472
J Leukoc Biol. 2002 Nov;72(5):856-63
12429707
Pharmacol Rev. 2003 Jun;55(2):241-69
12773629
Science. 1991 May 3;252(5006):698-702
1902591
Genes Immun. 2000 Oct;1(7):442-50
11196675
Structure. 1995 Jun 15;3(6):591-601
8590020
J Immunol. 2001 Oct 1;167(7):3545-9
11564763
Nat Rev Immunol. 2007 Jun;7(6):425-8
17525751
FEBS Lett. 2009 Apr 2;583(7):1072-7
19285080
Oncogene. 2001 Oct 25;20(48):7051-63
11704829
Cytokine. 2005 Jul 21;31(2):109-18
15899585
J Biol Chem. 1999 Jun 4;274(23):16513-21
10347215
J Immunol. 2004 Feb 15;172(4):2006-10
14764663
J Biol Chem. 2000 Oct 6;275(40):31335-9
10875937
J Clin Invest. 1994 Jan;93(1):424-8
8282815
Cancer Biol Ther. 2008 Jul;7(7):1109-15
18698163
Am J Physiol. 1997 Sep;273(3 Pt 1):L676-83
9316504
Science. 1996 Jul 26;273(5274):464-71
8662530
J Immunol. 2002 Oct 15;169(8):4288-97
12370360
Vitam Horm. 2006;74:61-76
17027511
Nature. 2007 Feb 8;445(7128):648-51
17187052
Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1295-8
15213397
Proc Natl Acad Sci U S A. 1990 Sep;87(18):6934-8
2169613
Curr Pharm Des. 2004;10(31):3873-84
15579076
BMC Struct Biol. 2005 Jun 28;5:10
15985167
Lupus. 1995 Oct;4(5):393-5
8563734
Structure. 2002 Aug;10(8):1051-62
12176383
J Biol Chem. 2009 Sep 25;284(39):26377-84
19632985
J Immunol. 2002 Jun 1;168(11):5397-402
12023331
Nat Immunol. 2003 Jan;4(1):63-8
12469119
Arthritis Rheum. 2000 Aug;43(8):1790-800
10943869
J Immunol. 2005 Mar 15;174(6):3695-702
15749908
Cancer Res. 2003 Aug 15;63(16):5105-13
12941841
Acta Crystallogr D Biol Crystallogr. 2000 Jan;56(Pt 1):14-24
10666622
J Leukoc Biol. 2009 Jul;86(1):23-32
19304895
Nature. 2002 Jan 24;415(6870):389-95
11807545
Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S23-37
14508078
Cell. 2008 Jan 25;132(2):259-72
18243101
Nat Immunol. 2003 Jan;4(1):69-77
12483210
Biochemistry. 2003 Nov 4;42(43):12617-24
14580208
Immunity. 2008 Dec 19;29(6):958-70
19084435
Nat Genet. 2009 Oct;41(10):1105-9
19749757
Neuroendocrinology. 2004;80(6):394-424
15838182
Acta Crystallogr D Biol Crystallogr. 1993 Nov 1;49(Pt 6):513-21
15299487
Arthritis Rheum. 2005 Apr;52(4):1037-46
15818686
J Biol Chem. 2002 Dec 6;277(49):47517-23
12351624
J Interferon Res. 1985 Winter;5(1):11-22
3989332
J Biol Chem. 2006 Nov 17;281(46):35088-96
16982608
J Invest Dermatol. 2003 Dec;121(6):1306-11
14675174
J Mol Biol. 2008 Oct 24;382(5):1168-83
18675824
Oncogene. 2003 Nov 24;22(53):8608-18
14634622
Hepatology. 2006 Oct;44(4):896-906
17006906
Nat Immunol. 2009 Jan;10(1):83-91
19029903
J Immunol. 2001 May 15;166(10):5859-63
11342597
J Interferon Cytokine Res. 2002 Nov;22(11):1099-112
12513909
Nat Immunol. 2005 Nov;6(11):1123-32
16200070
Mol Ther. 2005 Oct;12(4):707-15
16054437
Blood. 2010 Mar 4;115(9):1718-26
19965640
Arthritis Rheum. 2003 Oct;48(10):2773-8
14558082