Hybrid bioinorganic insulin amyloid fibrils.
Herein we report a method to functionalize in vitro grown insulin amyloid fibrils with various inorganic materials. The counterion of the positively charged amyloid fibril is exchanged with anions from various salts; subsequent addition of appropriate cations results in functionalization of the amyloid fibril. We demonstrate the formation of apatite and platinum complex structures ordered by the amyloid template.
Tang
Qun
Q
Biomolecular and Organic Electronics, IFM, Linköping University, SE-581 83 Linköping, Sweden.
Solin
Niclas
N
Lu
Jun
J
Inganäs
Olle
O
D000682:Amyloid / Q000737:chemistry* / Q000648:ultrastructure*; D001031:Apatites / Q000737:chemistry; D007328:Insulin / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D010984:Platinum / Q000737:chemistry; D012492:Salts / Q000737:chemistry
D000682:Amyloid; D001031:Apatites; D007328:Insulin; D007477:Ions; D012492:Salts; D010984:Platinum