Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain.
BACKGROUND
Protease inhibitors, including the Kunitz, Kazal, serpin and mucus families, play important roles in inhibiting protease activities during homeostasis, inflammation, tissue injury, and cancer progression. Interestingly, in addition to their anti-protease activity, protease inhibitors also often possess other intrinsic properties that contribute to termination of the inflammatory process, including modulation of cytokine expression, signal transduction and tissue remodeling. In this review we have tried to summarize recent findings on the Kunitz family of serine proteinase inhibitors and their implications in health and disease.


METHODS
A systematic search was performed in the electronic databases PubMed and ScienceDirect up to October 2009. We tried to limit the review to anti-inflammatory actions and actions not related to protease inhibition.


CONCLUSIONS
Recent studies have demonstrated that the Kunitz inhibitors are not only protease inhibitors, but can also prevent inflammation and tissue injury and subsequently promote tissue remodeling.
Shigetomi
Hiroshi
H
Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan.
Onogi
Akira
A
Kajiwara
Hirotaka
H
Yoshida
Shozo
S
Furukawa
Naoto
N
Haruta
Shoji
S
Tanase
Yasuhito
Y
Kanayama
Seiji
S
Noguchi
Taketoshi
T
Yamada
Yoshihiko
Y
Oi
Hidekazu
H
Kobayashi
Hiroshi
H
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D015842:Serine Proteinase Inhibitors
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