[Pathogenesis of atopic dermatitis].
Although atopic dermatitis (AD) is a very frequent disease in our society, it is still poorly understood. AD mainly results from a complex interaction between a cutaneous barrier dysfunction, a dysregulation of the immune system and environmental factors. Recent studies have highlighted new mutations in genes coding for skin proteins inducing AD. Furthermore, a new cytokine named TSLP was discovered. TSLP plays a major role in allergic inflammation and represents a big step further in the understanding of AD pathogenesis. However, there are still a lot of unknown factors in this disease, which are actually thouroughly investigated in numerous studies.
Lang
Caroline
C
Service de dermatologie et de vénéréologie, Hôpital de Beaumont, Avenue de Beaumont 29 CHUV, 1011 Lausanne.
Kypriotou
Magdalini
M
Christen-Zaech
Stéphanie
S
D016207:Cytokines / Q000235:genetics; D003876:Dermatitis, Atopic / Q000235:genetics / Q000503:physiopathology*; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics; D012879:Skin Physiological Phenomena; D000094632:Thymic Stromal Lymphopoietin
D016207:Cytokines; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D000094632:Thymic Stromal Lymphopoietin