title: Identification of atypical scrapie in Canadian sheep.
abstract: Scrapie, a transmissible spongiform encephalopathy of sheep and goats, exists in most small ruminant-producing countries of the world. A novel form of this disease was recently recognized and is known by various names, including Nor98, Nor98-like, and atypical scrapie. Differing from classic scrapie in epidemiology, histopathology, and biochemical characteristics, atypical scrapie cases have been identified throughout Europe and in the United States. Enhanced scrapie surveillance efforts recently identified 3 cases of atypical scrapie in Canada.
authors.affiliation: Canadian Food Inspection Agency, Ottawa Laboratory-Fallowfield, 3851 Fallowfield Road, Ottawa, Ontario, Canada, K2H 8P9.
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mitchell
authors.forename: Katherine I
authors.initials: KI
authors.lastname: O'Rourke
authors.forename: Noel P
authors.initials: NP
authors.lastname: Harrington
authors.forename: Andrei
authors.initials: A
authors.lastname: Soutyrine
authors.forename: Marion M
authors.initials: MM
authors.lastname: Simmons
authors.forename: Sandor
authors.initials: S
authors.lastname: Dudas
authors.forename: Dongyue
authors.initials: D
authors.lastname: Zhuang
authors.forename: Hubert
authors.initials: H
authors.lastname: Laude
authors.forename: Aru
authors.initials: A
authors.lastname: Balachandran
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002170:Canada / Q000453:epidemiology; D003062:Codon / Q000235:genetics; D015511:Goat Diseases / Q000453:epidemiology / Q000821:virology; D006041:Goats; D015151:Immunoblotting / Q000379:methods; D018620:PrPSc Proteins / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D017096:Prion Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D011328:Prions / Q000235:genetics / Q000472:pathogenicity; D012608:Scrapie / Q000453:epidemiology*; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000821:virology; D014481:United States
chemical_list: D003062:Codon; D018620:PrPSc Proteins; D011328:Prions