title: Primary lymphoepithelioma-like carcinoma of the ureter.
abstract: Lymphoepithelioma-like carcinoma (LELC) is an uncommon tumor of the urinary tract. We present a case of LELC involving the ureter of a 71-year-old male patient with gross hematuria. On biopsy, the patient was diagnosed with invasive poorly differentiated carcinoma, with a final diagnosis of LELC on subsequent nephroureterectomy. On resection, the neoplasm was solitary and consisted of undifferentiated neoplastic cells demonstrating a syncytial growth pattern, vesicular nuclei, prominent nucleoli, and an admixed polyclonal lymphoid infiltrate. Immunohistochemistry showed that the tumor cells were positive for Cam5.2 and CK7; focally positive for cytokeratinAE1/3, EMA, CK20, and p63; and negative for CK903. Epstein-Barr virus in situ hybridization was negative. No disease progression was noted at 5-month follow-up. Only 6 previous cases of LELC involving the ureter have been reported in the literature. We document an additional example of this uncommon entity and present a comprehensive review of LELC involving the ureter.
authors.affiliation: Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Daniela S
authors.initials: DS
authors.lastname: Allende
authors.forename: Mihir
authors.initials: M
authors.lastname: Desai
authors.forename: Donna E
authors.initials: DE
authors.lastname: Hansel
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D053552:Keratin-7 / Q000378:metabolism; D007633:Keratins / Q000378:metabolism; D008297:Male; D016896:Treatment Outcome; D014513:Ureter / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014516:Ureteral Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D019459:Urothelium / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; C400901:CAM 5.2 antigen; D053552:Keratin-7; D007633:Keratins