title: MASPECTRAS 2: An integration and analysis platform for proteomic data.
abstract: MASPECTRAS 2 is a freely available platform for integrating MS protein identifications with information from the major bioinformatics databases (ontologies, domains, literature, etc.). It assists researchers in understanding their data and publishing through sample comparisons, targeted queries, summaries, and exports in multiple formats such as PRIDE XML (Jones et al., Nucleic Acids Res. 2008, 36, D878-D883). MASPECTRAS 2 also comprises mechanisms to facilitate its integration in a high-throughput infrastructure. We illustrate application of MASPECTRAS 2 with unpublished tyrosine kinase inhibitor drug proteomics profiles in cancerous cells.
authors.affiliation: Institute for Genomics and Bioinformatics, Graz University of Technology, Austria.
authors.forename: Ceereena
authors.initials: C
authors.lastname: Ubaida Mohien
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hartler
authors.forename: Florian
authors.initials: F
authors.lastname: Breitwieser
authors.forename: Uwe
authors.initials: U
authors.lastname: Rix
authors.forename: Lily
authors.initials: L
authors.lastname: Remsing Rix
authors.forename: Georg E
authors.initials: GE
authors.lastname: Winter
authors.forename: Gerhard G
authors.initials: GG
authors.lastname: Thallinger
authors.forename: Keiryn L
authors.initials: KL
authors.lastname: Bennett
authors.forename: Giulio
authors.initials: G
authors.lastname: Superti-Furga
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Trajanoski
authors.forename: Jacques
authors.initials: J
authors.lastname: Colinge
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology; D045744:Cell Line, Tumor; D000069439:Dasatinib; D030562:Databases, Protein; D006801:Humans; D013058:Mass Spectrometry; D009363:Neoplasm Proteins / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D040901:Proteomics / Q000379:methods*; D011743:Pyrimidines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012984:Software; D013844:Thiazoles / Q000494:pharmacology; D014584:User-Computer Interface
chemical_list: D000814:Aniline Compounds; D009363:Neoplasm Proteins; D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011804:Quinolines; D013844:Thiazoles; C471992:bosutinib; D000069439:Dasatinib