CFP: a web-server for constructing sequence-based protein conformational flexibility profiles.
Many proteins contain conformationally flexible segments that undergo significant changes in the backbone conformation or completely lack a well-defined conformation. Previously, we have developed the generalized local propensity (GLP), a quantitative sequence-based measure of the protein backbone flexibility. In this paper, we present the CFP (Conformational Flexibility Profile) web-server that constructs the GLP flexibility profile for a user-submitted sequence and uses this profile to identify segments with high backbone flexibility. The statistical significance of a flexible sequence segment is assessed using the discrete scan statistics based on the density of flexible residues observed in this segment.


BACKGROUND
CFP is publicly available at http://cfp.rit.albany.edu.
Kuznetsov
Igor B
IB
Cancer Research Center, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA. ikuznetsov@uamail.albany.edu
Rackovsky
Shalom
S
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