Synthesis of stilbene-fused 2'-hydroxychalcones and flavanones.
Synthesis of stilbene-fused chalcones and flavanones were successfully completed. Molecules were designed in a way to mimic the structural features of both "stilbene and chalcones" or "stilbene and flavanones" at the same time, and synthesized by three steps. Heck reactions of 3-bromobenzaldehyde with styrene derivatives gave corresponding (E)-stilbenes, which were reacted with acetophenones to furnish stilbene-fused 2'-hydroxychalcones under basic conditions. Finally, intramolecular cyclization reactions were performed to produce stilbene-fused flavanones.
Akçok
Ismail
I
Izmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla-Izmir 35430, Turkey.
Cağir
Ali
A
D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D044950:Flavanones / Q000138:chemical synthesis*; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry
D047188:Chalcones; D044950:Flavanones; D013267:Stilbenes; C013031:2'-hydroxychalcone