Multimodality cardiovascular molecular imaging technology.
Cardiovascular molecular imaging is a new discipline that integrates scientific advances in both functional imaging and molecular probes to improve our understanding of the molecular basis of the cardiovascular system. These advances are driven by in vivo imaging of molecular processes in animals, usually small animals, and are rapidly moving toward clinical applications. Molecular imaging has the potential to revolutionize the diagnosis and treatment of cardiovascular disease. The 2 key components of all molecular imaging systems are the molecular contrast agents and the imaging system providing spatial and temporal localization of these agents within the body. They must deliver images with the appropriate sensitivity and specificity to drive clinical applications. As work in molecular contrast agents matures and highly sensitive and specific probes are developed, these systems will provide the imaging technologies required for translation into clinical tools. This is the promise of molecular medicine.
O'Donnell
Matthew
M
University of Washington, Seattle, Washington, USA.
McVeigh
Elliot R
ER
Strauss
H William
HW
Tanaka
Atsushi
A
Bouma
Brett E
BE
Tearney
Guillermo J
GJ
Guttman
Michael A
MA
Garcia
Ernest V
EV
D000162:Acoustics; D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000473:pathology; D002319:Cardiovascular System / Q000473:pathology*; D003196:Computer Graphics; D003287:Contrast Media / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008954:Models, Biological; D041622:Tomography, Optical / Q000379:methods; D014463:Ultrasonography / Q000379:methods; D014584:User-Computer Interface
D003287:Contrast Media
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