title: In vitro paradoxical growth of Pythium insidiosum in the presence of caspofungin.
abstract: Pythium insidiosum is a zoosporic organism which causes pythiosis in humans and animals. This study aimed to report the paradoxical growth of Brazilian P. insidiosum strains when submitted to in vitro susceptibility tests with caspofungin. The growth at concentrations above the minimal inhibitory concentration (MIC) ranged from 16 to 128 μg/ml and it was observed in 50% of the isolates tested. This paradoxical growth in the presence of caspofungin has been observed with Candida and Aspergillus strains, however, the phenomenon involving oomycetes was described here for the first time.
authors.affiliation: Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Juliana S
authors.initials: JS
authors.lastname: Argenta
authors.forename: Sydney H
authors.initials: SH
authors.lastname: Alves
authors.forename: Flávio
authors.initials: F
authors.lastname: Silveira
authors.forename: Grazieli
authors.initials: G
authors.lastname: Maboni
authors.forename: Daniela I B
authors.initials: DI
authors.lastname: Pereira
authors.forename: Andreia
authors.initials: A
authors.lastname: Spanamberg
authors.forename: Janio M
authors.initials: JM
authors.lastname: Santurio
authors.forename: Laerte
authors.initials: L
authors.lastname: Ferreiro
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001938:Brazil; D000077336:Caspofungin; D054714:Echinocandins / Q000494:pharmacology*; D006734:Horse Diseases / Q000188:drug therapy / Q000382:microbiology*; D006736:Horses; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D058968:Pythiosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin