title: [Multiple myeloma complicated with Takotsubo cardiomyopathy].
abstract: A 67-year-old woman with refractory multiple myeloma was admitted to our hospital for salvage therapy. She developed fever several days after chemotherapy was initiated and complained of chest pain. Since abnormal electrocardiogram was demonstrated. Emergency coronary angiography was performed, but the coronary artery did not demonstrate stenosis. Thereafter, the patient was diagnosed as having takotsubo cardiomyopathy. Hydragogue and nitric acid preparation transiently improved chest symptoms, but high fever persisted despite antibiotic and antifungal agents. She died on the 9th day after the initiation of chemotherapy. Physicians need to be aware that cardiomyopathy may develop as a severe side effect of chemotherapy.
authors.affiliation: Department of Hematology and Oncology, Faculty of Medicine, University of Yamanashi.
authors.forename: Toru
authors.initials: T
authors.lastname: Mitsumori
authors.forename: Kei
authors.initials: K
authors.lastname: Nakajima
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nozaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hamanaka
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nagashima
authors.forename: Keita
authors.initials: K
authors.lastname: Kirito
authors.forename: Noriaki
authors.initials: N
authors.lastname: Iwao
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D016879:Salvage Therapy / Q000009:adverse effects; D054549:Takotsubo Cardiomyopathy / Q000209:etiology*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D011239:Prednisolone; D008558:Melphalan