Knitting complex weaves with DNA origami.
The past three decades have witnessed steady growth in our ability to harness DNA branched junctions as building blocks for programmable self-assembly of diverse supramolecular architectures. The DNA-origami method, which exploits the availability of long DNA sequences to template sophisticated nanostructures, has played a major role in extending this trend through the past few years. Today, two-dimensional and three-dimensional custom-shaped nanostructures comparable in mass to a small virus can be designed, assembled, and characterized with a prototyping cycle on the order of a couple of weeks.
Shih
William M
WM
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. William_Shih@dfci.harvard.edu
Lin
Chenxiang
C
D001483:Base Sequence; D004247:DNA / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*
D004247:DNA
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