title: Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study.
abstract: BACKGROUND
  The relationship between cigarette smoking and incidence of acoustic neuromas and pituitary tumours is uncertain.
  
  
  METHODS
  We examined the relation between smoking and risk of acoustic neuromas and pituitary tumours in a prospective study of 1.2 million middle-aged women in the United Kingdom.
  
  
  RESULTS
  Over 10.2 million person years of follow-up, 177 women were diagnosed with acoustic neuromas and 174 with pituitary tumours. Current smokers at recruitment were at significantly reduced risk of incident acoustic neuroma compared with never smokers (adjusted relative risk (RR)=0.41, 95% confidence interval (CI)=0.24-0.70, P=0.001). Past smokers did not have significantly different risk of acoustic neuroma than never smokers (RR=0.87, 95% CI=0.62-1.22, P=0.4). Smoking was not associated with incidence of pituitary tumours (RR in current vs never smokers=0.91, 95% CI=0.60-1.40, P=0.7).
  
  
  CONCLUSIONS
  Women who smoke are at a significantly reduced risk of acoustic neuromas, but not of pituitary tumours, compared with never smokers. Acoustic neuromas are much rarer than the cancers that are increased among smokers.
authors.affiliation: Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK.
authors.forename: V S
authors.initials: VS
authors.lastname: Benson
authors.forename: J
authors.initials: J
authors.lastname: Green
authors.forename: K
authors.initials: K
authors.lastname: Pirie
authors.forename: V
authors.initials: V
authors.lastname: Beral
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000453:epidemiology* / Q000209:etiology; D010911:Pituitary Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology*
references.citation: Cancer Causes Control. 2009 Dec;20(10):1927-38
references.pmid: 19568697
references.citation: Annu Rev Pathol. 2009;4:97-126
references.pmid: 19400692
references.citation: Br J Cancer. 2008 Jul 8;99(1):185-90
references.pmid: 18560401
references.citation: Eur J Endocrinol. 2005 Apr;152(4):491-9
references.pmid: 15817903
references.citation: Neuro Oncol. 2006 Jan;8(1):1-11
references.pmid: 16443943
references.citation: Breast Cancer Res. 1999;1(1):73-80
references.pmid: 11056681
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1492-500
references.pmid: 19423526
references.citation: Int J Cancer. 2010 Oct 1;127(7):1692-8
references.pmid: 20091865
references.citation: Otol Neurotol. 2005 Jan;26(1):93-7
references.pmid: 15699726
references.citation: Int J Cancer. 2007 Jan 1;120(1):103-10
references.pmid: 17019705