Mortality from ischaemic heart disease: age-specific effects of blood pressure stratified by body-mass index: the HUNT cohort study in Norway.
BACKGROUND
Blood pressure is positively associated with ischaemic heart disease (IHD) mortality, but the strength of the association declines with age, and may differ between lean and obese people.


OBJECTIVE
To study the association of blood pressure with IHD mortality stratified by attained age (<65 and ≥65 years) and by body mass index (BMI).


METHODS
Prospective cohort study.


METHODS
General population with baseline measurements in 1984-1986. Participants 34,633 men and 36,749 women. MEASUREMENTS, Standardised measurements of blood pressure and BMI conducted by trained personnel, and information on potentially confounding factors was retrieved from self-administered questionnaires. Information on deaths from IHD was obtained from the Causes of Death Registry in Norway from baseline until the end of 2004.


RESULTS
During 2 years of follow-up, 2,529 men and 1,719 women had died from IHD. The association of blood pressure with IHD mortality was stronger in people younger than 65 years than in older age groups (p for interaction, 0.001), and the association was further modified by BMI (p for interaction, 0.001). In this age group, the RR of death from IHD associated with systolic pressure ≥160 mm Hg in lean (BMI<25) people was 5.8 (95% CI 3.8 to 8.7) compared with the reference (systolic pressure 120-139 mm Hg and BMI <25), and in overweight (BMI 25-29) and obese (BMI≥30) people, the corresponding relative risks were 2.4 (95% CI 1.6 to 3.5) and 1.6 (95% CI 0.9 to 2.8), respectively.


CONCLUSIONS
The association of blood pressure with IHD mortality is modified by age and body mass index.
Mørkedal
Bjørn
B
Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Romundstad
Pål R
PR
Vatten
Lars J
LJ
D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality*; D009664:Norway / Q000453:epidemiology; D011446:Prospective Studies; D055815:Young Adult