title: Aspartyl proteinase, phospholipase, hemolytic activities and biofilm production of Candida albicans isolated from bronchial aspirates of ICU patients.
abstract: A correlation between mucosal colonization by Candida albicans and the subsequent development of invasive respiratory infection has been previously described. The aim of this study was to evaluate different enzymatic activities in vitro and to determine the capacity to form biofilms by 17 C. albicans isolates from bronchial aspirates of mechanically ventilated patients hospitalized in intensive care units. All the C. albicans clinical isolates tested were biofilm producers and displayed detectable levels of proteinase and hemolytic activities, although phospholipase activity was not detected in one strain. The correlation noted among the virulence factors studied suggests that the presence of more than one concurrent factor could facilitate the spread of infection.
authors.affiliation: Area of Microbiology, Department of Biomedical Sciences, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Sacristán
authors.forename: M T
authors.initials: MT
authors.lastname: Blanco
authors.forename: M A
authors.initials: MA
authors.lastname: Galán-Ladero
authors.forename: J
authors.initials: J
authors.lastname: Blanco
authors.forename: C
authors.initials: C
authors.lastname: Pérez-Giraldo
authors.forename: A C
authors.initials: AC
authors.lastname: Gómez-García
mesh_terms: D057055:Aspartic Acid Proteases / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D001980:Bronchi / Q000382:microbiology*; D002176:Candida albicans / Q000201:enzymology* / Q000302:isolation & purification* / Q000472:pathogenicity / Q000502:physiology; D006461:Hemolysis; D006801:Humans; D007362:Intensive Care Units; D010740:Phospholipases / Q000378:metabolism*; D012121:Respiration, Artificial; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D037521:Virulence Factors; D010740:Phospholipases; D057055:Aspartic Acid Proteases