title: PCM1 and schizophrenia: a replication study in the Northern Swedish population.
abstract: Previous studies implicated centrosomal dysfunction as a source of various neuropsychiatric disorders, including schizophrenia (SZ). Two recent reports [Gurling et al., 2006; Datta et al., 2008. Mol Psychiatry] described an association between polymorphisms in the PCM1 gene and SZ in a UK/Scottish population. In this study, we aimed to replicate these findings in a Northern Swedish association sample of 486 research subjects with SZ and 512 unrelated control individuals. We genotyped 12 previously described SNP markers and carried out haplotype analyses using the same multi-marker haplotypes previously reported. Though we could not replicate the association with SNPs rs445422 and rs208747, we did observe a significant protective association with intronic SNP rs13276297. Furthermore, we performed a meta-analysis comprising 1,794 SZ patients and 1,553 controls, which confirmed the previously reported association with rs445422 and rs208747. These data provide further evidence that PCM1-though certainly not a major risk factor in the Northern Swedish population-cannot be ruled out as a contributor to SZ risk and/or protection, and deserves further replication in larger populations to elucidate its role in disease etiology.
authors.affiliation: Applied Molecular Genomics Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, Antwerp, Belgium.
authors.forename: Lotte N
authors.initials: LN
authors.lastname: Moens
authors.forename: Shana
authors.initials: S
authors.lastname: Ceulemans
authors.forename: Maaike
authors.initials: M
authors.lastname: Alaerts
authors.forename: Maarten J A
authors.initials: MJ
authors.lastname: Van Den Bossche
authors.forename: An-Sofie
authors.initials: AS
authors.lastname: Lenaerts
authors.forename: Sonia
authors.initials: S
authors.lastname: De Zutter
authors.forename: Karl-Fredrik
authors.initials: KF
authors.lastname: Norrback
authors.forename: Rolf
authors.initials: R
authors.lastname: Adolfsson
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
mesh_terms: D000483:Alleles; D001324:Autoantigens / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden; D044465:White People / Q000235:genetics*
chemical_list: D001324:Autoantigens; D018797:Cell Cycle Proteins; C086074:PCM1 protein, human