Non-canonical activation of Notch signaling/target genes in vertebrates.
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.
Sanalkumar
Rajendran
R
Neuro-Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram, 695 014, Kerala, India.
Dhanesh
Sivadasan Bindu
SB
James
Jackson
J
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000378:metabolism*; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014714:Vertebrates / Q000378:metabolism*
D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D051880:Receptors, Notch
Development. 1995 Oct;121(10):3291-301
7588063
Neuron. 2007 Jul 19;55(2):201-15
17640523
Carcinogenesis. 2007 Sep;28(9):1867-76
17434929
Dev Biol. 2000 Dec 15;228(2):151-65
11112321
Trends Immunol. 2001 Mar;22(3):155-60
11286731
Invest Ophthalmol Vis Sci. 2000 Feb;41(2):552-60
10670488
Genes Dev. 2008 Jan 15;22(2):166-78
18198335
Curr Opin Immunol. 2005 Jun;17(3):259-66
15886115
Development. 2009 Jun;136(11):1823-33
19386663
Cancer Res. 2004 Nov 1;64(21):7794-800
15520185
Annu Rev Pathol. 2008;3:587-613
18039126
Nat Neurosci. 2005 Jun;8(6):709-15
15917835
Dev Cell. 2004 Feb;6(2):183-92
14960273
Cancer Biol Ther. 2009 Oct;8(19):1840-51
19717984
J Neurosurg. 2007 Mar;106(3):417-27
17367064
Cell Death Differ. 2009 Jun;16(6):879-89
19265851
Cancer Cell. 2003 Jun;3(6):565-76
12842085
Dev Cell. 2005 Jun;8(6):867-79
15935776
Genes Dev. 2006 Oct 1;20(19):2739-53
17015435
Cell Mol Life Sci. 2009 May;66(10):1631-46
19165418
Oncogene. 2008 Feb 28;27(10):1489-500
17873912
Stem Cells. 2008 Mar;26(3):621-9
18055448
Cell Stem Cell. 2008 Apr 10;2(4):356-66
18397755
Nature. 1999 Aug 26;400(6747):877-81
10476967
Biochim Biophys Acta. 2008 Sep;1782(9):489-97
18625307
Neurosci Lett. 2009 Dec 25;467(2):164-8
19833173
Neuron. 2000 May;26(2):383-94
10839357
PLoS Biol. 2009 Aug;7(8):e1000169
19668359
Nat Immunol. 2005 Mar;6(3):314-22
15665828
Development. 1997 Mar;124(6):1139-48
9102301
Mol Cell Biol. 1998 Apr;18(4):2230-9
9528794
Nat Rev Genet. 2003 Jan;4(1):39-49
12509752
Development. 2003 Apr;130(7):1391-402
12588854
Genes Dev. 2002 May 15;16(10):1167-81
12023297
Dev Neurosci. 2006;28(1-2):5-12
16508299
Dev Cell. 2009 Feb;16(2):245-55
19217426
Nature. 2005 Sep 8;437(7056):270-4
16025100
Development. 2001 Apr;128(7):1099-107
11245575
J Cell Physiol. 2003 Mar;194(3):237-55
12548545
Immunity. 1997 Feb;6(2):145-54
9047236
Cold Spring Harb Symp Quant Biol. 2008;73:367-75
19022772
Mol Cell Biol. 2000 Jun;20(11):3928-41
10805736
Cell. 1991 Aug 23;66(4):649-61
1831692
Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):543-53
12615665
Oncogene. 2000 Jan 27;19(4):556-61
10698525
Curr Biol. 2003 Aug 5;13(15):1348-54
12906797
Genes Dev. 2005 May 1;19(9):1028-33
15879553
Oncogene. 2009 Jan 15;28(2):219-30
18836481
Cell. 2006 Mar 10;124(5):973-83
16530044
Cell. 2006 Mar 10;124(5):883-5
16530033
J Immunol. 2004 Sep 15;173(6):3935-44
15356142
Nat Med. 2002 Sep;8(9):979-86
12185362
Immunity. 2004 May;20(5):611-22
15142529
J Neurochem. 2010 May;113(4):807-18
20067572
Int J Dev Biol. 2006;50(2-3):193-208
16479488
Teratology. 1999 Oct;60(4):226-39
10508976
Cell. 2009 Apr 17;137(2):216-33
19379690
Int J Biochem Cell Biol. 1997 Dec;29(12):1389-99
9570134
Dev Cell. 2009 Jan;16(1):58-69
19154718
Development. 2008 Aug;135(16):2757-65
18635610
Curr Biol. 2003 Feb 18;13(4):333-8
12593800
Nature. 2007 Sep 20;449(7160):351-5
17721509
J Biol Chem. 2004 Mar 19;279(12):11657-63
14701863
Mol Cell Biol. 2007 Jun;27(11):3982-94
17371842
Cells Tissues Organs. 2008;188(1-2):91-102
18196925
Cancer Res. 2005 Mar 15;65(6):2353-63
15781650
Dev Biol. 2006 May 15;293(2):565-80
16581056
Curr Opin Genet Dev. 2004 Feb;14(1):48-54
15108805
Exp Cell Res. 2005 Oct 15;310(1):218-28
16120441
Exp Cell Res. 2005 Jun 10;306(2):343-8
15925590
Nat Rev Neurosci. 2006 Feb;7(2):93-102
16429119
Mech Dev. 1998 Dec;79(1-2):39-50
10349619
Development. 1994 Sep;120(9):2385-96
7956819
Int J Gynecol Cancer. 2009 May;19(4):564-6
19509550
Lab Invest. 2006 Aug;86(8):842-52
16732296
Nature. 2006 Aug 17;442(7104):823-6
16799564
Science. 1999 Apr 30;284(5415):770-6
10221902
Curr Opin Cell Biol. 2007 Apr;19(2):166-75
17317139
J Exp Med. 2006 May 15;203(5):1329-42
16682500
Dev Neurosci. 2002;24(1):79-88
12145413
Nat Immunol. 2002 May;3(5):443-50
11967543
Endocr Rev. 2007 May;28(3):339-63
17409286
Mol Cell Biol. 2006 Jan;26(1):117-30
16354684
Curr Opin Genet Dev. 2002 Oct;12(5):524-33
12200157
Cell. 2000 Dec 8;103(6):957-69
11136980
Cell Res. 1999 Sep;9(3):179-88
10520600
Curr Biol. 1999 May 6;9(9):460-9
10322111
J Cell Biol. 2009 Jan 12;184(1):101-12
19124651
Oncogene. 2001 Dec 20;20(58):8342-57
11840327
J Immunol. 2002 Sep 15;169(6):3021-9
12218117
Genes Cells. 1996 Jan;1(1):1-9
9078362
Adv Med Sci. 2009;54(2):136-42
19758972
Dev Biol. 2008 Jan 15;313(2):556-67
18062953
Development. 1999 Apr;126(8):1689-702
10079231
Nature. 2005 Jun 16;435(7044):959-63
15959515
Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R9-13
12668592
Genes Dev. 2002 Apr 1;16(7):846-58
11937492
Development. 2004 Nov;131(22):5539-50
15496443
Cancer Res. 2004 Nov 1;64(21):7787-93
15520184
Development. 2005 Jun;132(12):2759-70
15901663
Stem Cells. 2006 Nov;24(11):2437-47
16888285
J Virol. 2005 Jun;79(12):7889-98
15919944
Nat Rev Mol Cell Biol. 2006 Sep;7(9):678-89
16921404
Blood. 2005 Aug 1;106(3):886-92
15845899
Int Immunol. 2002 Jun;14(6):637-45
12039915
Development. 1996 Dec;122(12):3765-73
9012498