title: Functional connectivity density mapping.
abstract: Brain networks with energy-efficient hubs might support the high cognitive performance of humans and a better understanding of their organization is likely of relevance for studying not only brain development and plasticity but also neuropsychiatric disorders. However, the distribution of hubs in the human brain is largely unknown due to the high computational demands of comprehensive analytical methods. Here we propose a 10(3) times faster method to map the distribution of the local functional connectivity density (lFCD) in the human brain. The robustness of this method was tested in 979 subjects from a large repository of MRI time series collected in resting conditions. Consistently across research sites, a region located in the posterior cingulate/ventral precuneus (BA 23/31) was the area with the highest lFCD, which suggest that this is the most prominent functional hub in the brain. In addition, regions located in the inferior parietal cortex (BA 18) and cuneus (BA 18) had high lFCD. The variability of this pattern across subjects was <36% and within subjects was 12%. The power scaling of the lFCD was consistent across research centers, suggesting that that brain networks have a "scale-free" organization.
authors.affiliation: National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. tomasi@bnl.gov
authors.forename: Dardo
authors.initials: D
authors.lastname: Tomasi
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000166:cytology* / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult
references.citation: Hum Brain Mapp. 2009 Oct;30(10):3127-41
references.pmid: 19235882
references.citation: Neuroimage. 2006 Feb 1;29(3):1000-6
references.pmid: 16139527
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
references.pmid: 20176931
references.citation: Neuroscientist. 2006 Dec;12(6):512-23
references.pmid: 17079517
references.citation: Science. 2003 Sep 26;301(5641):1870-4
references.pmid: 14512617
references.citation: J Neurosci. 2008 Sep 10;28(37):9239-48
references.pmid: 18784304
references.citation: Neuroimage. 2007 Nov 1;38(2):306-20
references.pmid: 17869543
references.citation: Neuroimage. 2005 Feb 15;24(4):1164-9
references.pmid: 15670694
references.citation: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references.pmid: 17704812
references.citation: Neuroimage. 2007 Feb 1;34(3):1171-81
references.pmid: 17157035
references.citation: Magn Reson Med. 1996 Mar;35(3):346-55
references.pmid: 8699946
references.citation: Cereb Cortex. 2009 Oct;19(10):2209-29
references.pmid: 19221144
references.citation: AJNR Am J Neuroradiol. 2001 Aug;22(7):1326-33
references.pmid: 11498421
references.citation: Nature. 1998 Jun 4;393(6684):440-2
references.pmid: 9623998
references.citation: Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):811-7
references.pmid: 9448245
references.citation: Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10237-9
references.pmid: 12149485
references.citation: Cereb Cortex. 2005 Sep;15(9):1332-42
references.pmid: 15635061
references.citation: Science. 2009 Jul 24;325(5939):412-3
references.pmid: 19628854
references.citation: J Neurosci. 2009 Feb 11;29(6):1860-73
references.pmid: 19211893
references.citation: Magn Reson Imaging. 2009 Oct;27(8):1019-29
references.pmid: 19375260
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references.pmid: 11209064
references.citation: Neuroimage. 2008 Nov 15;43(3):528-39
references.pmid: 18786642
references.citation: NMR Biomed. 2001 Nov-Dec;14(7-8):389-96
references.pmid: 11746930
references.citation: Magn Reson Med. 1995 Oct;34(4):537-41
references.pmid: 8524021
references.citation: Science. 1999 Oct 15;286(5439):509-12
references.pmid: 10521342
references.citation: J Neurosci Res. 2003 Oct 15;74(2):179-83
references.pmid: 14515346
references.citation: Hum Brain Mapp. 2006 Aug;27(8):694-705
references.pmid: 16404736
references.citation: J Neurosci. 2006 Jan 4;26(1):63-72
references.pmid: 16399673
references.citation: Neuroimage. 2006 Jan 15;29(2):452-66
references.pmid: 16140550
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11376-81
references.pmid: 19549821
references.citation: Am J Psychiatry. 2001 Jun;158(6):955-8
references.pmid: 11384907
references.citation: Magn Reson Imaging. 2002 May;20(4):305-17
references.pmid: 12165349
references.citation: Neuroimage. 2009 May 1;45(4):1107-16
references.pmid: 19349228
references.citation: J Neurosci. 2009 Jun 10;29(23):7619-24
references.pmid: 19515930
references.citation: PLoS Comput Biol. 2007 Feb 2;3(2):e17
references.pmid: 17274684
references.citation: Magn Reson Med. 2005 Nov;54(5):1261-7
references.pmid: 16215962