Evaluation of calcium dobesilate for its anti-cataract potential in experimental animal models.
The present study evaluated the protective action of calcium dobesilate (CDO) in various experimental models of cataract. CDO was studied in hydrocortisone-induced cataract in developing chick embryos and selenite-induced cataract in pups. CDO anti-cataract activity was also evaluated after oral and topical application as eye drops in galactose (30%) fed rats. This study was further extended to evaluate the intraocular penetration of a single dose of 1% CDO (50 microL) in rabbits. CDO exhibited significant protection against cataract in experimental models and considerable penetration after single topical application. Anti-cataract activity may be due to its antioxidant as well as aldose reductase inhibitor properties. Further studies are in progress to evaluate its clinical efficacy in diabetic cataract.
Velpandian
T
T
Department of Ocular Pharmacology and Pharmacy, All India Institute of Medical Sciences, New Delhi, India. tvelpandian@hotmail.com
Nirmal
J
J
Gupta
P
P
Vijayakumar
A R
AR
Ghose
S
S
D000284:Administration, Oral; D000287:Administration, Topical; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D002123:Calcium Dobesilate / Q000008:administration & dosage / Q000494:pharmacology*; D002386:Cataract / Q000188:drug therapy* / Q000503:physiopathology; D002642:Chick Embryo; D004195:Disease Models, Animal; D005260:Female; D005690:Galactose / Q000633:toxicity; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000633:toxicity; D008297:Male; D009883:Ophthalmic Solutions; D018384:Oxidative Stress; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000633:toxicity
D006490:Hemostatics; D009883:Ophthalmic Solutions; D002123:Calcium Dobesilate; D000449:Aldehyde Reductase; D018038:Sodium Selenite; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone; D005690:Galactose