title: From molecular mechanisms of cardiac development to genetic substrate of congenital heart diseases.
abstract: Congenital heart disease is one of the most important chapters in medicine because its incidence is increasing and nowadays it is close to 1.2%. Most congenital heart disorders are the result of defects during embryogenesis, which implies that they are due to alterations in genes involved in cardiac development. This review summarizes current knowledge regarding the molecular mechanisms involved in cardiac development in order to clarify the genetic basis of congenital heart disease.
authors.affiliation: University of Padua, Padua, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Cecchetto
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rampazzo
authors.forename: Annalisa
authors.initials: A
authors.lastname: Angelini
authors.forename: Lucia Dal
authors.initials: LD
authors.lastname: Bianco
authors.forename: Massimo
authors.initials: M
authors.lastname: Padalino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Stellin
authors.forename: Luciano
authors.initials: L
authors.lastname: Daliento
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D006321:Heart / Q000196:embryology; D006330:Heart Defects, Congenital / Q000209:etiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors