An update on Tourette syndrome.
Recent advances in our understanding of the phenomenology, etiology, pathophysiology, and treatment of Tourette syndrome are discussed. Tourette syndrome appears to involve dysfunction of limbic and somatosensory "traffic" through the basal ganglia, within corticostriatal-thalamocortical circuits. Dynamic alterations in the balance of these inputs may dictate the manifestations (sensory, motor, affective, and behavioral) of the disorder at any given time. Individualized assessment and treatment are the keys to optimal treatment of this condition.
Kimber
Thomas E
TE
Neurology Unit, Royal Adelaide Hospital, and Department of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia. thomas.kimber@health.sa.gov.au
D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D046690:Deep Brain Stimulation; D003952:Diagnostic Imaging; D006801:Humans; D005879:Tourette Syndrome / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy
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