Cytokine profiles before and after exchange transfusion in a neonate with transient myeloproliferative disorder and hepatic fibrosis.
To study the effect of exchange transfusion on cytokine profiles in a patient with transient myeloproliferative disorder and hepatic fibrosis in which cytokines were measured before and after exchange transfusion. A newborn female was diagnosed with Down syndrome phenotypically and on karyotyping. Laboratory data showed a high leukocyte count with blast cells in the peripheral blood and liver dysfunction. Exchange transfusion was performed on day 1. However, respiratory distress and multiorgan failure progressed, and she died after 16 days. Of the cytokines examined, transforming growth factor-beta1 and interleukin-7 were extremely high before exchange transfusion, and decreased after exchange transfusion.
Sugiura
Tokio
T
Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. sugitoki23@yahoo.co.jp
Goto
Kenji
K
Ninchoji
Takeshi
T
Aiba
Kaori
K
Kouwaki
Masanori
M
Koyama
Norihisa
N
Togari
Hajime
H
D004314:Down Syndrome / Q000378:metabolism*; D005078:Exchange Transfusion, Whole Blood; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015851:Interleukin-7 / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000628:therapy; D009196:Myeloproliferative Disorders / Q000378:metabolism* / Q000628:therapy; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D015851:Interleukin-7; D053773:Transforming Growth Factor beta1