title: CD163 expression is present in cutaneous histiocytomas but not in atypical fibroxanthomas.
abstract: CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. Recent work has shown that this marker is specific for neoplasms of histiocytic differentiation. Our aim was to test the ability of CD163 to separate cutaneous histiocytomas from their morphologic mimics. We tested the expression of CD163 in 78 cases, including 19 xanthogranulomas, 16 atypical fibroxanthomas, 6 reticulohistiocytomas, 8 epithelioid cell histiocytomas, 9 cases of Langerhans cell histiocytosis, 10 xanthomas, and 10 intradermal Spitz nevi. CD163 expression was seen in all xanthogranulomas and reticulohistiocytomas, 4 epithelioid cell histiocytomas, 2 cases of Langerhans cell histiocytosis, and 8 xanthomas but was absent in atypical fibroxanthomas and Spitz nevi. CD163 is an excellent marker for confirming histiocytic differentiation and is useful in eliminating morphologic mimics such as Spitz nevi from the differential diagnosis. The lack of CD163 in atypical fibroxanthomas argues against a histiocytic origin for this tumor.
authors.affiliation: Department of Pathology, Stanford University Medical Center, 300 Pasteur Drove, Stanford, CA 94305, USA.
authors.forename: Reena
authors.initials: R
authors.lastname: Sachdev
authors.forename: Jason
authors.initials: J
authors.lastname: Robbins
authors.forename: Sabine
authors.initials: S
authors.lastname: Kohler
authors.forename: Vijay
authors.initials: V
authors.lastname: Vanchinathan
authors.forename: Erich J
authors.initials: EJ
authors.lastname: Schwartz
authors.forename: Uma N
authors.initials: UN
authors.lastname: Sundram
mesh_terms: D000071443:12E7 Antigen; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D015260:Neprilysin / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis*; D051116:Receptors, Scavenger / Q000032:analysis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D000098902:CD163 Antigen
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D000098902:CD163 Antigen; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D011956:Receptors, Cell Surface; D051116:Receptors, Scavenger; D015260:Neprilysin