title: Central adiposity rather than total adiposity measurements are specifically involved in the inflammatory status from healthy young adults.
abstract: This study assessed the potential association of some proinflammatory markers with adiposity (total vs. central) and metabolic features in young adults. Measurements included body composition, lifestyle features, blood biochemical, and selected inflammatory indicators on 154 healthy subjects (53 M/101 F; 21.5 ± 3 years; 22.1 ± 2.6 kg/m(2)). Those subjects with higher waist circumference (WC) and waist-hip ratio (WHR) showed higher (P < 0.05) C-reactive protein (CRP), complement C3, interleukin-6 (IL6), and retinol binding protein-4 (RBP4) concentrations, while only IL6 was positively associated with total body fat (%). Furthermore, CRP and RBP4 were higher in former/current smokers, as compared to never smokers (P < 0.05). Some indicators of glucose (homeostasis model assessment-insulin resistance) and lipid metabolism (total cholesterol/high density lipoprotein-cholesterol and triglycerides) were positively associated with the assayed inflammatory markers (P < 0.05). The findings of this cross-sectional study indicate that central adiposity-related indicators (WC/WHR) correlated better than those assessing total adiposity with plasma proinflammatory markers, which additionally were associated with lifestyle and metabolic features in healthy young adults.
authors.affiliation: Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, C/ Irunlarrea, 1, 31008, Pamplona, Spain.
authors.forename: Helen Hermana M
authors.initials: HH
authors.lastname: Hermsdorff
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Zulet
authors.forename: Blanca
authors.initials: B
authors.lastname: Puchau
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology*; D018836:Inflammation Mediators / Q000097:blood*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000473:pathology; D056128:Obesity, Abdominal / Q000097:blood / Q000473:pathology; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003176:Complement C3; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D008055:Lipids; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D002097:C-Reactive Protein
references.citation: Nutr Metab (Lond). 2007 Dec 21;4:28
references.pmid: 18154661
references.citation: Int J Obes Relat Metab Disord. 2002 Jul;26(7):994-1008
references.pmid: 12080455
references.citation: Nature. 2006 Dec 14;444(7121):875-80
references.pmid: 17167476
references.citation: Arq Bras Endocrinol Metabol. 2004 Dec;48(6):803-11
references.pmid: 15761553
references.citation: OMICS. 2010 Jun;14(3):297-307
references.pmid: 20450441
references.citation: Nature. 2005 Jul 21;436(7049):356-62
references.pmid: 16034410
references.citation: J Clin Endocrinol Metab. 2007 Nov;92(11):4359-65
references.pmid: 17726085
references.citation: N Engl J Med. 2006 Jun 15;354(24):2552-63
references.pmid: 16775236
references.citation: Nutrition. 2009 Apr;25(4):392-9
references.pmid: 19056238
references.citation: Metabolism. 2006 Mar;55(3):415-21
references.pmid: 16483888
references.citation: Obesity (Silver Spring). 2007 Sep;15(9):2225-32
references.pmid: 17890490
references.citation: J Clin Endocrinol Metab. 2007 Jun;92(6):2330-5
references.pmid: 17405846
references.citation: Eur Heart J. 2010 Mar;31(6):737-46
references.pmid: 19933515
references.citation: Endocrine. 2009 Dec;36(3):445-51
references.pmid: 19816812
references.citation: Atherosclerosis. 2008 Nov;201(1):217-24
references.pmid: 18289552
references.citation: Diabetes. 2005 Feb;54(2):570-5
references.pmid: 15677517
references.citation: Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):625-30
references.pmid: 18813130
references.citation: Diabetes Care. 2009 Sep;32(9):1734-6
references.pmid: 19587368
references.citation: Circulation. 2007 Sep 11;116(11):1234-41
references.pmid: 17709633
references.citation: Eur Cytokine Netw. 2006 Mar;17(1):4-12
references.pmid: 16613757
references.citation: Med Clin (Barc). 2000 Nov 4;115(15):587-97
references.pmid: 11141395
references.citation: Int J Obes Relat Metab Disord. 2001 Oct;25(10):1407-15
references.pmid: 11673759
references.citation: Clin Chem. 1972 Jun;18(6):499-502
references.pmid: 4337382
references.citation: Med Clin (Barc). 2007 Feb 10;128(5):184-96; quiz 1 p following 200
references.pmid: 17298782
references.citation: Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):747-52
references.pmid: 15702630
references.citation: Atherosclerosis. 2000 Feb;148(2):209-14
references.pmid: 10657556
references.citation: Eur Heart J. 2005 Sep;26(17):1765-73
references.pmid: 15817606
references.citation: Int J Obes (Lond). 2005 Dec;29(12):1452-6
references.pmid: 16077717
references.citation: Am J Public Health. 1996 Jan;86(1):25-30
references.pmid: 8561237
references.citation: Cardiovasc Diabetol. 2007 Oct 01;6:27
references.pmid: 17903275
references.citation: Atherosclerosis. 2003 Jun;168(2):305-13
references.pmid: 12801614
references.citation: Diabetes Res Clin Pract. 2005 Jul;69(1):29-35
references.pmid: 15955385
references.citation: Adv Biol Med Phys. 1956;4:239-80
references.pmid: 13354513
references.citation: Nutr Hosp. 2007 Sep-Oct;22(5):511-27
references.pmid: 17970534
references.citation: J Clin Endocrinol Metab. 2008 Jun;93(6):2287-93
references.pmid: 18397979
references.citation: Public Health Nutr. 2005 Oct;8(7):920-7
references.pmid: 16277809
references.citation: J Clin Endocrinol Metab. 2007 Dec;92(12):4827-34
references.pmid: 17878249
references.citation: Am J Clin Nutr. 2006 Sep;84(3):505-12
references.pmid: 16960163
references.citation: Br J Nutr. 1974 Jul;32(1):77-97
references.pmid: 4843734
references.citation: Eur J Clin Nutr. 2003 Feb;57(2):285-92
references.pmid: 12571661
references.citation: World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
references.pmid: 11234459
references.citation: Diabetologia. 1985 Jul;28(7):412-9
references.pmid: 3899825
references.citation: Eur J Clin Nutr. 2009 Jul;63(7):858-64
references.pmid: 18985060
references.citation: J Clin Endocrinol Metab. 2000 Sep;85(9):3338-42
references.pmid: 10999830