A kidney tumor in an adolescent with severe hypertension and hypokalemia: an uncommon case--case report and review of the literature on reninoma.
This report presents a case of a 16-year-old hypertensive boy who presented to our clinic. Laboratory findings showed severe hypokalemia and markedly increased plasma renin activity. Abdominal ultrasonography and contrast-enhanced computed tomography of the abdomen revealed a well-circumscribed, solid, hypoenhancing cortical lesion (2 cm) in the lower pole of the left kidney. The patient underwent nephron-sparing surgery. Histopathologic examination gave a diagnosis of juxtaglomerular cell tumor. Reninoma is an uncommon cause of hypertension in a young adult and should be included in the differential diagnosis as a potential life-threatening and curable condition. The conservative surgical management is the gold standard for small, circumscribed lesions.
Gottardo
Fedra
F
Centre for Reproductive Medicine and Andrology, University of Münster, Germany. Fedra.Gottardo @ ukmuenster.de
Cesari
Maurizio
M
Morra
Aldo
A
Gardiman
Marina
M
Fassina
Ambrogio
A
Dal Bianco
Massimo
M
D000293:Adolescent; D001706:Biopsy; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D007008:Hypokalemia / Q000097:blood / Q000209:etiology*; D007606:Juxtaglomerular Apparatus / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D007680:Kidney Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D012083:Renin / Q000097:blood*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015854:Up-Regulation
D012083:Renin