title: FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients.
abstract: DNA variation at the FGF20 gene has been associated with Parkinson's disease (PD). In particular, SNP rs12720208 in the 3' untranslated region (3' UTR) was linked to PD-risk through a mechanism that would implicate a differential binding to microRNA-433 (miR-433). The reduction of the affinity of miR-433 to the 3' UTR would result in increased FGF20 expression and upregulation of alpha-synuclein, which could in turn promote dopaminergic neurons degeneration. We genotyped the rs12720208 SNP in a total of 512 PD patients and 258 healthy controls from Spain, and searched for miR-433 variants in the patients. We did not find significant differences in allele and genotype frequencies between patients and controls. None of the patients had miR-433 variants. In conclusion, our work did not confirm the association between rs12720208 and PD, or an effect of miR-433 variants on this disease.
authors.affiliation: Genética Molecular, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: de Mena
authors.forename: Lucía F
authors.initials: LF
authors.lastname: Cardo
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Ana
authors.initials: A
authors.lastname: Miar
authors.forename: Marta
authors.initials: M
authors.lastname: Díaz
authors.forename: Ana I
authors.initials: AI
authors.lastname: Corao
authors.forename: Belén
authors.initials: B
authors.lastname: Alonso
authors.forename: René
authors.initials: R
authors.lastname: Ribacoba
authors.forename: Carlos
authors.initials: C
authors.lastname: Salvador
authors.forename: Manuel
authors.initials: M
authors.lastname: Menéndez
authors.forename: Germán
authors.initials: G
authors.lastname: Morís
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
mesh_terms: D020413:3' Untranslated Regions; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D013030:Spain; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; C416003:FGF20 protein, human; C548883:MIRN433 microRNA, human; D035683:MicroRNAs; D005346:Fibroblast Growth Factors