title: Amine-promoted synthesis of vinyl aziridines.
abstract: N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regioselective nucleophilic aziridination of alpha,beta,gamma,delta-unsaturated carbonyl compounds. The reaction is completely regioselective (>95: 5) for the alpha,beta-alkene and completely diastereoselective, affording the trans-vinyl aziridine in moderate-to-good yields.
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom. a.armstrong@imperial.ac.uk
authors.forename: Alan
authors.initials: A
authors.lastname: Armstrong
authors.forename: Robert D C
authors.initials: RD
authors.lastname: Pullin
authors.forename: Chloe R
authors.initials: CR
authors.lastname: Jenner
authors.forename: James N
authors.initials: JN
authors.lastname: Scutt
mesh_terms: D000588:Amines / Q000737:chemistry*; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001388:Aziridines