title: A possible association between maternal otitis media and ear defect in their offspring.
abstract: BACKGROUND
  The possible association between otitis media in pregnancy (OMP) and structural birth defects, that is, congenital abnormalities (CAs), in their offspring has not been studied.
  
  
  METHODS
  The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, was evaluated.
  
  
  RESULTS
  There were 58 (0.25%) and 55 (0.14%) of 22 843 cases and 38 151 controls with mothers who had OMP, respectively. There was association of OMP and a higher risk of ear CA.
  
  
  CONCLUSIONS
  A possible explanation for the association of OMP with higher risk of ear CA may be some morphological deviation of the inner ear.
authors.affiliation: Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary.
authors.forename: Nándor
authors.initials: N
authors.lastname: Acs
authors.forename: Ferenc
authors.initials: F
authors.lastname: Bánhidy
authors.forename: Erzsébet H
authors.initials: EH
authors.lastname: Puhó
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Czeizel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D015897:Comorbidity; D016001:Confidence Intervals; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000453:epidemiology*; D004423:Ear / Q000002:abnormalities; D004427:Ear Diseases / Q000151:congenital / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016017:Odds Ratio; D010033:Otitis Media / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence; D012016:Reference Values; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents