title: Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus.
abstract: The antiviral neuraminidase inhibitor oseltamivir (OSV) is widely used to suppress viral replication in the treatment of influenza. Here, we report that OSV administration significantly suppressed respiratory mucosal secretory IgA responses with respect to antigen (Ag)-specific antibody (Ab) production and also the induction of Ag-specific IgA Ab-forming cells, but not systemic IgG responses, in weanling mice as a model of pediatric influenza. Neutralizing activities of the airway fluids in oral OSV-treated mice were significantly less than those of sham-treated mice. Our findings suggest the risk of re-infection in patients showing a low mucosal response following OSV treatment.
authors.affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, 3-15-18, Kuramoto-cho, Tokushima-city, Tokushima, 770-8503, Japan.
authors.forename: Etsuhisa
authors.initials: E
authors.lastname: Takahashi
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kataoka
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Fujii
authors.forename: Junji
authors.initials: J
authors.lastname: Chida
authors.forename: Dai
authors.initials: D
authors.lastname: Mizuno
authors.forename: Makoto
authors.initials: M
authors.lastname: Fukui
authors.lastname: Hiro-O Ito
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Fujihashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kido
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D018928:Immunity, Mucosal / Q000187:drug effects; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology*; D053139:Oseltamivir / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D053139:Oseltamivir