title: Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction: a prospective nested case-referent study.
abstract: OBJECTIVE
  Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction.
  
  
  METHODS
  First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferrin iron saturation and ferritin were analyzed, as well as several confounders. HFE C282Y and H63D genotypes were determined.
  
  
  RESULTS
  There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction.
  
  
  CONCLUSIONS
  No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
authors.affiliation: Clinical Chemistry, Department of Medical Biosciences, Umeå University, Umeå, Sweden. kim.ekblom@medbio.umu.se
authors.forename: Kim
authors.initials: K
authors.lastname: Ekblom
authors.forename: Stefan L
authors.initials: SL
authors.lastname: Marklund
authors.forename: Jan-Håkan
authors.initials: JH
authors.lastname: Jansson
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Lars
authors.initials: L
authors.lastname: Weinehall
authors.forename: Johan
authors.initials: J
authors.lastname: Hultdin
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D007501:Iron