title: Epileptic seizures in a descendant of Dom Pedro I.
abstract: Intrauterine seizure is a rare event. Genetic predisposition and trauma are possible risk factors.
  
  
  OBJECTIVE
  To review and comment on the historical description of intrauterine events of a bastard daughter of Dom Pedro I (Maria Isabel Alcântara Brasileira - 1830-1896).
  
  
  METHODS
  Review of historical facts about the health of Dom Pedro I's daughter according to primary and secondary historical data.
  
  
  RESULTS
  According to historical accounts, Dom Pedro I's daughter suffered trauma during the intrauterine period that provoked intrauterine seizures. At the age of eight years, she developed self-limited and benign generalized epilepsy. Like her father, she had mood problems and also learning difficulties.
  
  
  CONCLUSIONS
  Dona Maria Isabel's own report does not shown sufficient evidence to support the diagnosis of post-traumatic intrauterine seizures. Nevertheless, her family history suggests a genetic basis for her epilepsy.
authors.affiliation: Epilepsy Program, Instituto de Neurologia Deolindo Couto, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. mmotagomes@acd.ufrj.br
authors.forename: Marleide da Mota
authors.initials: Mda M
authors.lastname: Gomes
authors.forename: Heber de Souza
authors.initials: Hde S
authors.lastname: Maia Filho
mesh_terms: D001938:Brazil; D004827:Epilepsy / Q000235:genetics / Q000266:history*; D005315:Fetal Diseases / Q000266:history; D020022:Genetic Predisposition to Disease / Q000266:history; D049672:History, 19th Century; D006801:Humans