Are vitamin D receptor agonists like angiotensin-converting enzyme inhibitors without side effects?
Vitamin D receptor agonists (VDRAs) inhibit the renin-angiotensin system (RAS) and reduce podocyte loss and fibrosis over and above RAS blockade. Several studies in humans show that VDRAs are antiproteinuric and have the potential to delay the progression of renal disease. Whether VDRAs will accomplish this goal among proteinuric patients with chronic kidney disease needs to be tested in randomized controlled trials.
Agarwal
Rajiv
R
Indiana University School of Medicine and Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA. ragarwal@iupui.edu
D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D018450:Disease Progression; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004872:Ergocalciferols / Q000009:adverse effects / Q000627:therapeutic use*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D019808:Losartan / Q000009:adverse effects / Q000627:therapeutic use*; D051379:Mice; D018167:Receptors, Calcitriol / Q000819:agonists* / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects; D014815:Vitamins / Q000009:adverse effects / Q000627:therapeutic use*
D047228:Angiotensin II Type 1 Receptor Blockers; D015415:Biomarkers; D004872:Ergocalciferols; D016326:Extracellular Matrix Proteins; D018836:Inflammation Mediators; D018167:Receptors, Calcitriol; D014815:Vitamins; C084656:paricalcitol; D003404:Creatinine; D019808:Losartan