Rhabdomyosarcoma of the head and neck: a clinicopathological and immunohistochemical analysis of 29 cases.
Rhabdomyosarcoma is a malignant tumor occurring more frequently in the childhood. The purpose of this study was to analyze the clinicopathological and immunohistochemical features of rhabdomyosarcomas of the head and neck (RHNs). Twenty nine patients treated in a single institution were selected. The histological slides were reviewed and the tumors were classified. The immunohistochemical reactions were performed using antibodies against vimentin, desmin, myogenin, MyoD1, AE1/AE3, p53, PCNA, Ki67, C-erbB2, FAS and CDK4. The mean age was 14.3 years. The nonparameningeal site was affected in 16 cases (55.2%). Eleven cases (37.9%) affected parameningeal sites and 2 cases the orbit. The p53 was positive in 4 cases (13.8%), CDK4 in 10 cases (34.5%), C-erbB2 in 19 cases (70.4%), FAS in 9 cases (31%), PCNA in 28 cases (96.5%) and Ki67 in 16 cases (55.2%). The overall survival was 28.7% in 5 and 10 years, and p53 expression may be related with poor prognosis.
Andrade
Cléverton Roberto de
CR
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Campinas, SP, Brazil.
Takahama Junior
Ademar
A
Nishimoto
Inês Nobuko
IN
Kowalski
Luiz Paulo
LP
Lopes
Márcio Ajudarte
MA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D051358:Cyclin-Dependent Kinase 4 / Q000032:analysis; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008577:Meningeal Neoplasms / Q000453:epidemiology; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000453:epidemiology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000453:epidemiology*; D012737:Sex Factors; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D055815:Young Adult; D019014:fas Receptor / Q000032:analysis
D051358:Cyclin-Dependent Kinase 4; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor; C491901:FAS protein, human; C495900:CDK4 protein, human