Associations of visceral and subcutaneous fat areas with the prevalence of metabolic risk factor clustering in 6,292 Japanese individuals: the Hitachi Health Study.
OBJECTIVE
We examined the relationships of visceral fat area (VFA), subcutaneous fat area, and waist circumference, determined using computed tomography (CT), and BMI with metabolic risk factors in a large Japanese population.


METHODS
Study subjects comprised 6,292 men and women who participated in the Hitachi Health Study and received CT examinations in 2007 and 2008.


RESULTS
Regarding the clustering of metabolic risk factors, the odds ratios (ORs) for the VFA quintiles were 1.0 (ref.), 2.4, 3.4, 5.0, and 9.7 for men and 1.0 (ref.), 1.5, 2.6, 4.6, and 10.0 for women (P < 0.001 for trends in both sexes). For the highest quintiles, the OR for VFA was 1.5 to 2 times higher than those of the other anthropometric indexes in both sexes.


CONCLUSIONS
We demonstrated a superior performance of VFA to predict the clustering of metabolic risk factors compared with other anthropometric indexes.
Matsushita
Yumi
Y
Department of Epidemiology and International Health, National Center for Global Health and Medicine, Tokyo, Japan. ymatsushita@ri.ncgm.go.jp
Nakagawa
Toru
T
Yamamoto
Shuichiro
S
Takahashi
Yoshihiko
Y
Yokoyama
Tetsuji
T
Noda
Mitsuhiko
M
Mizoue
Tetsuya
T
D000328:Adult; D000368:Aged; D044466:Asian People; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000378:metabolism*
Diabetes Care. 2001 Apr;24(4):683-9
11315831
J Atheroscler Thromb. 2005;12(6):301
16394611
Circulation. 2004 Jan 27;109(3):433-8
14744958
JAMA. 2002 Dec 4;288(21):2709-16
12460094
Endocr Rev. 2000 Dec;21(6):697-738
11133069
Diabetes Care. 2010 Jan;33(1):184-9
19837793
Circulation. 2005 Oct 25;112(17):2735-52
16157765
Circulation. 2007 Jul 3;116(1):39-48
17576866
Int J Obes Relat Metab Disord. 1996 Jun;20(6):533-8
8782729