title: Relationship between chronic trauma of the oral mucosa, oral potentially malignant disorders and oral cancer.
abstract: BACKGROUND
  Oral cancer represents 2%-5% of all cancers, being one of the 10 most frequent ones. Apart from oral cancer risk factors already described in literature, such as tobacco and alcohol consumption, others emerging risk factors have been proposed, such as chronic irritation from dental factors. The aim of this work was to assess the influence of chronic trauma of the oral mucosa (CTOM) in patients with oral potentially malignant disorders (OPMD) and cancer.
  
  
  METHODS
  A retrospective study of 406 patients (both sexes; aged between 18 and 80 years; with OPMD and cancer) who attended the Department of Clinical Stomatology A of the National University of Cordoba was performed by non-probabilistic sampling. The association of variables and outcome variable diagnosis, with levels control, OPMD, oral cancer, was evaluated by multinomial regression model.
  
  
  RESULTS
  Population under study was represented by 72% of control patients, 16% patients with OPMD and 11% of patients with oral cancer. It was observed a significant association between diagnosis and CTOM (P = 0.000), after adjustment of confounding factors (smoking and drinking habits, sex, cancer inheritance and denture use).
  
  
  CONCLUSIONS
  Our results suggest that CTOM is, together with other factors, an important risk factor in patients with oral cancer diagnosis, but not for patients with OPMD.
authors.affiliation: Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Eduardo David
authors.initials: ED
authors.lastname: Piemonte
authors.forename: Jerónimo Pablo
authors.initials: JP
authors.lastname: Lazos
authors.forename: Mabel
authors.initials: M
authors.lastname: Brunotto
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D018289:Carcinoma, Verrucous / Q000453:epidemiology; D002908:Chronic Disease; D015986:Confounding Factors, Epidemiologic; D003778:Dentures / Q000706:statistics & numerical data; D004358:Drug Therapy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000293:injuries*; D009062:Mouth Neoplasms / Q000209:etiology* / Q000235:genetics; D011159:Population Surveillance; D011230:Precancerous Conditions / Q000209:etiology* / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult