[Evaluation of curative and palliative treatment of duodenal adenocarcinoma].
BACKGROUND
Primary adenocarcinoma of the duodenum is a rare disease in this part of the world, and data on survival following curative and palliative treatment are scarce.


METHODS
All patients treated for duodenal cancer (DC) at the Department of Surgery, Odense University Hospital, between January 1995 and February 2006 were retrospectively evaluated. Tumours arising from the pancreatic head, the papilla of Vater, distal bile duct or tumour infiltration from surrounding organs (apart from the duodenum) were excluded.


RESULTS
Eleven (31%) of the 35 included patients (17 women and 18 men, median age 62 years, range 45-88 years) received a curative resection (R0 resection), while 24 patients had surgical or endoscopic palliation. Survival following R0 resection was significantly higher than survival in the palliative group (p = 0.0002). The median survival was 45 months (confidence interval (CI) 6- ) in the R0 group versus 5.3 months (CI 2-11) in the palliative group.


CONCLUSIONS
In a consecutive, but retrospective DC population, we found that only one third of the patients were candidates for a curative resection, and despite microscopical, radical surgery only one third were alive after five years.
Bendixen
Morten
M
Kirurgisk Afdeling A, Odense Universitetshospital, 5000 Odense C, Denmark. pinseferie@gmail.com
Dahl
Sune
S
Fristrup
Claus
C
Mortensen
Michael Bau
MB
D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D004379:Duodenal Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery* / Q000628:therapy; D004386:Duodenum / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome