title: Maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models.
abstract: BACKGROUND
  Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution.
  
  
  OBJECTIVE
  We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted geostatistical (TAG) model with a finer spatial resolution, for use in pregnancy studies.
  
  
  METHODS
  The AQMS and TAG exposure models were implemented in two areas surrounding medium-size cities in which 776 pregnant women were followed as part of the EDEN mother-child cohort. The exposure models were compared in terms of estimated nitrogen dioxide (NO2) levels and of their association with birth weight.
  
  
  RESULTS
  The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively. Exposure patterns displayed greater spatial than temporal variations. Exposure during the first trimester of pregnancy was most strongly associated with birth weight for women living < 2 km away from an AQMS: a 10-µg/m3 increase in NO2 exposure was associated with an adjusted difference in birth weight of -37 g [95% confidence interval (CI), -75 to 1 g] for the nearest-AQMS model and of -51 g (95% CI, -128 to 26 g) for the TAG model. The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS.
  
  
  CONCLUSIONS
  The two exposure models tended to give consistent results in terms of association with birth weight, despite the moderate concordance between exposure estimates.
authors.affiliation: INSERM, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Institut Albert Bonniot, Grenoble, France. johanna.lepeule@ujf-grenoble.fr
authors.forename: Johanna
authors.initials: J
authors.lastname: Lepeule
authors.forename: Fabrice
authors.initials: F
authors.lastname: Caïni
authors.forename: Sébastien
authors.initials: S
authors.lastname: Bottagisi
authors.forename: Julien
authors.initials: J
authors.lastname: Galineau
authors.forename: Agnès
authors.initials: A
authors.lastname: Hulin
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marquis
authors.forename: Aline
authors.initials: A
authors.lastname: Bohet
authors.forename: Valérie
authors.initials: V
authors.lastname: Siroux
authors.forename: Monique
authors.initials: M
authors.lastname: Kaminski
authors.forename: Marie-Aline
authors.initials: MA
authors.lastname: Charles
authors.forename: Rémy
authors.initials: R
authors.lastname: Slama
mesh_terms: D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005602:France; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008962:Models, Theoretical; D009585:Nitrogen Dioxide / Q000633:toxicity*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
chemical_list: D009585:Nitrogen Dioxide
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