Meat mutagens and breast cancer in postmenopausal women--a cohort analysis.
BACKGROUND
Mutagenic compounds produced when meats are cooked at high temperatures have been hypothesized to increase risk of breast cancer.


METHODS
We examined the association between intakes of the heterocyclic amines (HCA) MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline), PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]), and meat-derived mutagenic (MDM) activity and risk of breast cancer using a cooking method questionnaire administered in 1996 in the Nurses' Health Study. Between 1996 and 2006, 2,317 breast cancer cases were diagnosed during 533,618 person-years.


RESULTS
Higher intake of HCAs or MDM was not associated with elevated risk of breast cancer [multivariate relative risk and 95% confidence interval for the highest versus lowest quintile: MeIQx: 0.90 (0.79-1.03); PhIP: 0.92 (0.80-1.05); DiMeIQx: 0.92 (0.80-1.05); and MDM: 0.98 (0.85-1.12)]. HCA or MDM was not associated with estrogen receptor-positive/progesterone receptor-positive breast cancer risk either. There was some suggestion of a decreased risk of estrogen receptor-negative/progesterone receptor-negative breast cancer with higher intakes of MeIQx, DiMeIQx, and PhIP, but none of the associations were statistically significant. There was little evidence for an interaction between intake of cruciferous vegetables and HCA or MDM intake and risk of breast cancer.


CONCLUSIONS
Higher consumption of mutagens from meats cooked at higher temperature and longer duration was not associated with increased risk of postmenopausal breast cancer.


CONCLUSIONS
Overall prospective data including results from our study do not provide support for a substantial increase in risk of breast cancer with higher intake of HCAs.
Wu
Kana
K
Department of Nutrition, Harvard School of Public Health, and Department of Medicine, Brigham and Women's Hospital, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA. kana.wu@channing.harvard.edu
Sinha
Rashmi
R
Holmes
Michelle D
MD
Giovannucci
Edward
E
Willett
Walter
W
Cho
Eunyoung
E
D000328:Adult; D001943:Breast Neoplasms / Q000139:chemically induced*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D009153:Mutagens / Q000009:adverse effects*; D009726:Nurses / Q000706:statistics & numerical data; D017698:Postmenopause; D011810:Quinoxalines / Q000009:adverse effects*; D012307:Risk Factors; D011795:Surveys and Questionnaires
D007093:Imidazoles; D009153:Mutagens; D011810:Quinoxalines; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
J Natl Cancer Inst. 2000 Aug 16;92(16):1352-4
10944558
Carcinogenesis. 2002 May;23(5):831-8
12016157
Cancer Res. 1999 Oct 15;59(20):5154-9
10537291
Carcinogenesis. 2004 Dec;25(12):2509-17
15319301
Cancer Res. 2007 Oct 1;67(19):9597-602
17909072
Mol Carcinog. 2005 Jul;43(3):155-64
15924352
Cancer Epidemiol Biomarkers Prev. 2000 Sep;9(9):905-10
11008907
Mutat Res. 2001 Sep 1;480-481:285-97
11506821
Mutat Res. 1975 Dec;31(6):347-64
768755
Cancer Epidemiol Biomarkers Prev. 1999 Mar;8(3):233-9
10090301
Breast Dis. 2005-2006;24:3-15
16917136
J Chromatogr. 1992 Feb 21;592(1-2):271-8
1583097
Br J Cancer. 2009 Jul 7;101(1):178-84
19513076
Cancer Epidemiol Biomarkers Prev. 1995 Jul-Aug;4(5):567-71
7549816
Environ Mol Mutagen. 2002;39(2-3):165-70
11921185
Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2146-51
18669582
Environ Mol Mutagen. 2002;39(2-3):112-8
11921178
Int J Cancer. 2009 May 15;124(10):2430-5
19165862
Epidemiology. 2007 May;18(3):373-82
17435448
Cancer Epidemiol Biomarkers Prev. 1998 Jun;7(6):523-9
9641497
Environ Mol Mutagen. 2004;44(1):44-55
15199546
Mutat Res. 2002 Sep 30;506-507:197-204
12351159
Arch Intern Med. 2006 Nov 13;166(20):2253-9
17101944
Curr Drug Metab. 2004 Apr;5(2):169-80
15078194
Food Chem Toxicol. 1997 May;35(5):433-41
9216741
Carcinogenesis. 2000 Apr;21(4):607-15
10753193
Int J Cancer. 2008 Oct 1;123(7):1637-43
18636564
J Natl Cancer Inst. 1998 Nov 18;90(22):1724-9
9827527
J Am Med Womens Assoc (1972). 1995 Mar-Apr;50(2):40-4
7722205
J Natl Cancer Inst. 2004 Feb 4;96(3):218-28
14759989
Food Chem Toxicol. 1995 Jul;33(7):545-51
7628789
Food Chem Toxicol. 2002 May;40(5):673-84
11955674
J Mammary Gland Biol Neoplasia. 1998 Jan;3(1):49-61
10819504
Cancer Sci. 2004 Apr;95(4):290-9
15072585
Cancer Epidemiol Biomarkers Prev. 1997 Aug;6(8):573-81
9264269
Mutat Res. 1997 May 12;376(1-2):195-202
9202756
Nutr Cancer. 2003;46(2):212-21
14690798
Nutr Cancer. 2009;61(1):36-46
19116874
Int J Epidemiol. 1989 Dec;18(4):858-67
2621022
Am J Epidemiol. 1985 Jul;122(1):51-65
4014201
Mutat Res. 2002 Sep 30;506-507:153-62
12351155
Food Chem Toxicol. 1994 Oct;32(10):897-903
7959444
Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):801-8
12223422