[Diagnostic significance of some indices of systemic inflammation in peritonitis].
The blood concentration of histamine, serotonin, endothelial-monocytic activating polypeptide II (EMAP II). activity of elastase, as well as general clinical markers of inflammation, the leucocytes quantity in peripheral blood and the average mass peptides level in particular, were studied in 72 patients with an acute peritonitis. It was established, that highest level of histamine, serotonin, the elastase activity in serum are characteristic for spread peritonitis and somewhat lower--for the diffuse one. The EMAP II level is most lowered in diffuse and somewhat lesser in case of spread peritonitis. Value of these markers of inflammation had differed concerning the peritonitis cause existed. Between elastase activity raising and EMAP II concentration the back proportional dependence was established. The peritonitis spread stage diagnosis and planning of its treatment become possible when complex considering of the inflammation mediators and EMAP II content is done together with endogenic intoxication indices and clinical symptoms severity.
Mishchuk
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Pyptiuk
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D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D010196:Pancreatic Elastase / Q000097:blood*; D010538:Peritonitis / Q000097:blood* / Q000150:complications; D011237:Predictive Value of Tests; D016601:RNA-Binding Proteins / Q000097:blood*; D012701:Serotonin / Q000097:blood*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000209:etiology
D015415:Biomarkers; D016207:Cytokines; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; C077219:small inducible cytokine subfamily E, member 1; D012701:Serotonin; D006632:Histamine; D010196:Pancreatic Elastase