title: The MIF -173G/C polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population.
abstract: Migration inhibitory factor (MIF) has recently been defined as a novel pro-tumorigenic factor that promotes cell proliferation, migration, and invasion. The MIF -173C allele results in increased MIF promoter activity and is associated with a higher serum MIF level. We hypothesized that this polymorphism may contribute to childhood acute lymphoblastic leukemia (ALL) susceptibility. We genotyped the MIF -173G/C polymorphism (rs755622) in 346 ALL cases and 516 cancer-free controls in a Chinese population and found that the variant genotype GC and the combined genotypes GC/CC were associated with a significantly higher risk of childhood ALL [adjusted odds ratio (OR)=1.39, 95% confidence interval (CI)=1.01-1.93 for GC and adjusted OR=1.38, 95% CI=1.01-1.89 for GC/CC]. In addition, we found that the increased risk was more pronounced among high-risk ALL and B-phenotype ALL patients. Our results suggest that the MIF -173G/C polymorphism is involved in the etiology of childhood ALL and is a potential candidate gene for determining cancer susceptibility. Further validations in other populations are warranted.
authors.affiliation: Department of Hematology and Oncology, The Affiliated Nanjing Children's Hospital of Nanjing Medical University, No. 72 Guanzhou Road, Nanjing 210008, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Xue
authors.forename: Hongyan
authors.initials: H
authors.lastname: Xu
authors.forename: Liucheng
authors.initials: L
authors.lastname: Rong
authors.forename: Qin
authors.initials: Q
authors.lastname: Lu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D019746:Intramolecular Oxidoreductases / Q000235:genetics* / Q000502:physiology; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics* / Q000502:physiology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human