Fly fishing for collective cell migration.
The collective migration of cells is essential for organogenesis. It requires the establishment of spatial information within the cellular group and a mechanism that controls the onset of cell movement and migratory arrest. In this review I will use two examples of collective cell migration, from Drosophila and the zebrafish, to discuss how genetic analyses have helped to unravel some basic aspects of collective cell migration. Following, I will suggest some general experimental approaches to further advance our understanding of the mechanisms that control the migration of cellular collectives.
López-Schier
Hernán
H
Laboratory of Sensory Cell Biology & Organogenesis, Centre de Regulació Genòmica, Dr. Aiguader 88, Barcelona, Spain. hernan.lopez@crg.es
D000818:Animals; D002465:Cell Movement / Q000235:genetics* / Q000502:physiology; D004330:Drosophila / Q000166:cytology* / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000378:metabolism; D038081:Organogenesis / Q000235:genetics; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics; D029961:Zebrafish Proteins / Q000235:genetics / Q000502:physiology
D029721:Drosophila Proteins; D029961:Zebrafish Proteins