Advance of studies on anti-atherosclerosis mechanism of berberine.
Coptis Chinensis is a traditional Chinese medicine herb that has the effect of clearing heat and drying dampness, purging fire to eliminate toxin. Berberine is the main alkaloid of Coptis Chinensis, and, recent researches showed that berberine had the effect of anti-atherosclerosis. This paper reviewed the anti-atherosclerosis mechanism of berberine, which may be related to regulating lipids, anti-inflammation, decompression, reducing blood sugar, and inhibiting vascular smooth muscle cell proliferation.
Wu
Min
M
Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China.
Wang
Jie
J
Liu
Long-tao
LT
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000517:prevention & control*; D001599:Berberine / Q000494:pharmacology* / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000517:prevention & control; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood
D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D008055:Lipids; D001599:Berberine
Circulation. 1997 Nov 18;96(10):3264-5
9396412
Stroke. 1995 Nov;26(11):2016-22
7482641
J Biomed Sci. 2005 Oct;12(5):791-801
16132116
Eur J Pharmacol. 2000 Jul 7;399(2-3):187-96
10884519
N Engl J Med. 1999 Jan 14;340(2):115-26
9887164
Atherosclerosis. 2006 May;186(1):29-37
16098530
Biochem Pharmacol. 2006 Mar 14;71(6):806-17
16448624
Metabolism. 2008 May;57(5):712-7
18442638
Annu Rev Pathol. 2006;1:297-329
18039117
Cardiovasc Drug Rev. 2001 Fall;19(3):234-44
11607041
Thromb Res. 2002 May 15;106(4-5):223-7
12297129
Acta Pharmacol Sin. 2000 May;21(5):477-80
11324451
Planta Med. 1999 May;65(4):381-3
10364850
Biochem Pharmacol. 2005 Oct 15;70(8):1176-84
16140275
Diabetes. 2008 May;57(5):1414-8
18285556
Cancer Lett. 2004 Jan 20;203(2):127-37
14732220
Blood Press. 2007;16(4):238-45
17852092
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Mar;17(3):162-4
9863084
Nat Med. 2004 Dec;10(12):1344-51
15531889
J Agric Food Chem. 2007 Dec 12;55(25):10437-45
18001034
World J Gastroenterol. 2008 Feb 14;14(6):876-83
18240344
Cardiovasc Res. 2006 Oct 1;72(1):9-17
16824498
J Lipid Res. 2006 Jun;47(6):1281-8
16508037
Acta Pharmacol Sin. 2006 Feb;27(2):173-8
16412266
Pharmazie. 2008 May;63(5):384-8
18557425
Biol Pharm Bull. 2008 Jun;31(6):1169-76
18520050
Eur J Pharmacol. 2008 Aug 20;590(1-3):343-54
18590725
Curr Drug Targets. 2007 Nov;8(11):1181-9
18045096
Biol Pharm Bull. 2005 Aug;28(8):1431-7
16079488
Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):881-3, 934
17655135