Double stranded DNA discrimination by di-pyrene modified gamma-cyclodextrin.
Neutral fluorescent active di-pyrene modified gamma-cyclodextrin (1) was synthesized in order to discriminate with single and double strand DNA (ssDNA and dsDNA, respectively) with high selectivity. The binding and selectivity of 1 for dsDNA was indicated by increase of the fluorescent intensity in an addition of dsDNA. On the other hand, an increase of fluorescent intensity of 1 was not recognized in an addition of ssDNA.
Takeda
Akane
A
Department of Material-Process and Applied Chemistry for Environments, Graduate School of Engineering and Resource Science, Akita University, Akita 010-8502, Japan.
Akimoto
Kazuhiko
K
Kondo
Yoshihiko
Y
Hamada
Fumio
F
D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D011721:Pyrenes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D047408:gamma-Cyclodextrins / Q000737:chemistry*
D011721:Pyrenes; D047408:gamma-Cyclodextrins; D004247:DNA; C023792:gamma-cyclodextrin