Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain.
Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.
Sousa
Vitor H
VH
Smilow Neuroscience Program, Department of Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA.
Fishell
Gord
G
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002454:Cell Differentiation; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013687:Telencephalon / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D000074482:Thyroid Nuclear Factor 1; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000071676:Zinc Finger Protein GLI1
D053823:Hedgehog Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; C465570:Shh protein, mouse; D000074482:Thyroid Nuclear Factor 1; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1; D005346:Fibroblast Growth Factors
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