title: Update on HHV-8-Associated Malignancies.
abstract: The human herpesvirus 8 (HHV-8) is the oncogenic virus associated with Kaposi's sarcoma (KS) and lymphoproliferative disorders, namely, primary effusion lymphoma and multicentric Castleman's disease. KS is among the most common malignancies seen in HIV-infected patients despite the decreased incidence of KS in the era of highly active antiretroviral therapy. Advances in molecular pathology reveal HHV-8 tumorigenesis is mediated through molecular mimicry wherein viral-encoded proteins can activate several cellular signaling cascades while evading immune surveillance. This knowledge has led to the evolution of multiple therapeutic strategies against specific molecular targets. Many such therapeutic modalities have shown activity, but none have proven to be curative. Identifying possible prognostic factors is another active area of research. This review summarizes the recent developments in the fields of virus transmission, molecular biology, and treatment of HHV-8-related neoplasms.
authors.forename: Meena
authors.initials: M
authors.lastname: Sunil
authors.forename: Erin
authors.initials: E
authors.lastname: Reid
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: Lechowicz
references.citation: Curr Opin Infect Dis. 2007 Apr;20(2):152-6
references.pmid: 17496573
references.citation: Blood. 2000 Feb 15;95(4):1406-12
references.pmid: 10666218
references.citation: J Clin Oncol. 2007 Aug 1;25(22):3350-6
references.pmid: 17664482
references.citation: Clin Transplant. 2010 Jan-Feb;24(1):127-32
references.pmid: 19919613
references.citation: J Infect Dis. 2006 Apr 15;193(8):1054-62
references.pmid: 16544245
references.citation: Lancet. 1990 Jan 20;335(8682):123-8
references.pmid: 1967430
references.citation: Int J Cancer. 2007 Mar 1;120(5):1129-35
references.pmid: 17154170
references.citation: Blood. 2002 Nov 1;100(9):3415-8
references.pmid: 12384445
references.citation: Br J Haematol. 2008 May;141(4):559-61
references.pmid: 18341641
references.citation: Int Urol Nephrol. 2009;41(3):679-85
references.pmid: 19009366
references.citation: PLoS Pathog. 2006 Oct;2(10):e116
references.pmid: 17069461
references.citation: Biol Blood Marrow Transplant. 2008 May;14(5):601-2
references.pmid: 18410904
references.citation: J Virol. 2007 Dec;81(23):12836-45
references.pmid: 17881434
references.citation: Ann Intern Med. 2007 Dec 18;147(12):836-9
references.pmid: 18087054
references.citation: Am J Surg Pathol. 2008 Jul;32(7):1006-12
references.pmid: 18469709
references.citation: Clin Infect Dis. 2008 Sep 1;47(5):684-8
references.pmid: 18652555
references.citation: Blood. 2007 Feb 15;109(4):1550-8
references.pmid: 17047149
references.citation: J Clin Oncol. 2008 Nov 10;26(32):5297-9
references.pmid: 18854561
references.citation: Virology. 2008 May 25;375(1):94-102
references.pmid: 18321555
references.citation: Blood. 2000 Nov 1;96(9):3279-81
references.pmid: 11050015
references.citation: N Engl J Med. 2005 Mar 31;352(13):1317-23
references.pmid: 15800227
references.citation: Science. 2007 Apr 27;316(5824):604-8
references.pmid: 17463289
references.citation: Cancer Lett. 2008 May 18;263(2):182-8
references.pmid: 18234418
references.citation: Blood. 1995 Aug 15;86(4):1276-80
references.pmid: 7632932
references.citation: N Engl J Med. 2007 Sep 27;357(13):1352-3
references.pmid: 17898112
references.citation: PLoS Pathog. 2007 May 11;3(5):e65
references.pmid: 17500590
references.citation: Mod Pathol. 2009 May;22(5):618-26
references.pmid: 19287457
references.citation: PLoS One. 2009 May 19;4(5):e5613
references.pmid: 19479040
references.citation: Semin Cancer Biol. 2008 Dec;18(6):423-36
references.pmid: 18948197
references.citation: AIDS. 2007 Jul 31;21(12):1541-5
references.pmid: 17630548
references.citation: J Clin Virol. 2009 Jan;44(1):81-3
references.pmid: 18835212
references.citation: Cancer Lett. 2010 Mar 28;289(2):140-50
references.pmid: 19651473
references.citation: Transplantation. 2009 Jan 27;87(2):157-63
references.pmid: 19155967
references.citation: Clin Infect Dis. 2009 Dec 15;49(12):1946-9
references.pmid: 19911999
references.citation: Nat Genet. 2006 Jun;38 Suppl:S25-30
references.pmid: 16736021
references.citation: Nature. 2007 Dec 13;450(7172):1096-9
references.pmid: 18075594
references.citation: Am J Surg Pathol. 2007 Sep;31(9):1439-45
references.pmid: 17721201
references.citation: Leukemia. 2009 Oct;23(10):1867-74
references.pmid: 19554030
references.citation: N Engl J Med. 1995 May 4;332(18):1186-91
references.pmid: 7700311
references.citation: Mol Immunol. 2007 Feb;44(6):1352-60
references.pmid: 16828498
references.citation: AIDS. 2008 May 11;22(8):937-45
references.pmid: 18453853
references.citation: J Korean Med Sci. 2009 Oct;24(5):970-4
references.pmid: 19795003
references.citation: Am J Transplant. 2008 Mar;8(3):707-10
references.pmid: 18261181
references.citation: Mol Cancer Ther. 2007 Aug;6(8):2360-70
references.pmid: 17699731
references.citation: AIDS. 2008 Jun 19;22(10):1232-4
references.pmid: 18525273
references.citation: J Virol. 2008 Feb;82(3):1518-25
references.pmid: 18032494
references.citation: Br J Haematol. 2009 Nov;147(3):405-8
references.pmid: 19681885
references.citation: Lancet. 2006 May 6;367(9521):1495-502
references.pmid: 16679162
references.citation: J Clin Oncol. 2006 Mar 20;24(9):1389-94
references.pmid: 16549833
references.citation: Cancer. 2007 Aug 25;111(4):224-33
references.pmid: 17554754
references.citation: J Virol. 2008 May;82(9):4235-49
references.pmid: 18305042
references.citation: J Infect Dis. 2009 Aug 1;200(3):430-8
references.pmid: 19534596
references.citation: Am J Hematol. 2008 Jun;83(6):498-503
references.pmid: 18260115
references.citation: Am J Epidemiol. 2008 Aug 1;168(3):311-20
references.pmid: 18515794
references.citation: Cancer Cell. 2006 Aug;10(2):133-43
references.pmid: 16904612
references.citation: J Med Virol. 2008 Dec;80(12):2153-60
references.pmid: 19040293
references.citation: PLoS Pathog. 2007 Sep 7;3(9):1348-60
references.pmid: 17907806
references.citation: J Infect Dis. 2008 Jul 1;198(1):23-30
references.pmid: 18491970
references.citation: Br J Haematol. 2008 Jan;140(1):13-24
references.pmid: 17991301
references.citation: Lancet. 1981 Sep 19;2(8247):598-600
references.pmid: 6116083
references.citation: J Infect Dis. 2006 Oct 15;194(8):1078-88
references.pmid: 16991082
references.citation: Transplantation. 2008 Sep 15;86(5):738-44
references.pmid: 18791457
references.citation: N Engl J Med. 2008 Jan 31;358(5):535-6; author reply 536
references.pmid: 18234764
references.citation: J Virol. 1999 May;73(5):4156-70
references.pmid: 10196312
references.citation: Int J Cancer. 2008 Jul 1;123(1):187-94
references.pmid: 18435450
references.citation: AIDS. 2008 May 31;22(9):1019-28
references.pmid: 18520345
references.citation: AIDS. 2008 Jun 19;22(10):1236-7
references.pmid: 18525275
references.citation: Am J Transplant. 2008 Apr;8(4):906-7
references.pmid: 18294348
references.citation: J Infect Dis. 2007 Jul 15;196(2):199-207
references.pmid: 17570106
references.citation: Pathol Int. 2006 Oct;56(10):617-24
references.pmid: 16984619
references.citation: Blood. 2008 May 1;111(9):4731-40
references.pmid: 18199825
references.citation: Clin Infect Dis. 2008 Nov 1;47(9):1209-15
references.pmid: 18808357
references.citation: Science. 1994 Dec 16;266(5192):1865-9
references.pmid: 7997879