title: Antimicrobial activity and chemical composition of endemic Centaurea cariensis subsp. niveo-tomentosa.
abstract: The antimicrobial activity of the n-hexane, chloroform, ethyl acetate and ethyl alcohol extracts of the aerial parts of Centaurea cariensis subsp. niveo-tomentosa was evaluated against microorganisms, including multi-antibiotic resistant bacteria, using the paper disc diffusion method. The chemical composition of the chloroform extract of this plant was determined by gas chromatography and gas chromatography-mass spectrometry. The chloroform extract exhibited significant antibacterial activity for all bacteria tested, which are important pathogens. The major compounds of the chloroform extract were caryophyllene oxide (20.79%), spathulenol (14.73%), beta-eudesmol (9.27%), beta-caryophyllene (6.84%), n-cetylalcohol (6.27%), cubenol (5.23%) and cis-alpha-santalol (4.67%), respectively.
authors.affiliation: Department of Biology, Faculty of Arts and Sciences, Mugla University, 48121 Kotekli-Mugla, Turkey. ayselugur@hotmail.com
authors.forename: Aysel
authors.initials: A
authors.lastname: Ugur
authors.forename: Nurdan
authors.initials: N
authors.lastname: Sarac
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ceylan
authors.forename: M
authors.initials: M
authors.lastname: Emin Duru
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D031179:Centaurea / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts