"Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness.
Huntington's disease has been linked with fronto-subcortical neuropathology and behaviors consistent with this dysfunction. Little is known about these "frontal" behaviors in the earliest phase of the illness. Comparisons between participants in the Predict-HD study (745 "expansion-positive" and 163 "expansion-negative" control subjects) on the Frontal System Behavior Scale looked for evidence of frontal behaviors, including apathy, disinhibition, and executive dysfunction. The authors were also able to compare participant and companion reporting of these frontal behaviors as a possible indication of awareness of behaviors. Expansion-positive individuals reported significantly more of these frontal behaviors than expansion-negative peers. Self- and companion-reported frontal behaviors were related to other Huntington's disease markers. Expansion-positive participants closest to Huntington's disease diagnosis showed greater discrepancies with companions on ratings of frontal behaviors. Even though most are more than 10 years from Huntington's disease diagnosis, mild frontal behaviors were present in this prediagnosed sample, which might make these behaviors useful as markers for Huntington's disease onset. Participant/companion discrepancies, especially closest to Huntington's disease diagnosis, might suggest early lack of awareness in these individuals.
Duff
Kevin
K
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA. kevin.duff@hsc.utah.edu
Paulsen
Jane S
JS
Beglinger
Leigh J
LJ
Langbehn
Douglas R
DR
Wang
Chiachi
C
Stout
Julie C
JC
Ross
Christopher A
CA
Aylward
Elizabeth
E
Carlozzi
Noelle E
NE
Queller
Sarah
S
D000328:Adult; D003342:Corpus Striatum / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D009929:Organ Size; D011336:Probability; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012649:Self Concept; D012720:Severity of Illness Index; D013997:Time Factors
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