title: Association of interaction between smoking and CYP 2C19*3 polymorphism with coronary artery disease in a Uighur population.
abstract: OBJECTIVE
  Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation. The purpose of this study is to explore the relationship between the interaction of CYP2C19*3 polymorphism and smoking and coronary artery disease (CAD) in a Uighur population.
  
  
  METHODS
  In a Chinese Uighur case-control study of patients with CAD (n = 336) and healthy controls (n = 370), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  The CYP2C19*3 AG + AA genotype was significantly more prevalent in patients with CAD (6.25.0% vs 2.96%; P = .03). Multiple logistic regression analysis showed 4 independent risk factors: the interaction of CYP2C19*3 and smoking (OR 7.22, 95% confidence interval [CI] 2.32-10.23; P = .009), smoking (OR 3.23, 95% CI 1.72-5.44; P = .003), blood sugar (OR 2.12, 95% CI 1.03-4.21; P < .01), and hypertension (OR 1.74, 95% CI 0.98-2.34; P = .013).
  
  
  CONCLUSIONS
  The CYP2C19*3 polymorphism and CAD were synergistically and significantly associated in Chinese Uighur patients.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Xin-Lei
authors.initials: XL
authors.lastname: Wang
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000209:etiology* / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19