title: Biodegradable therapeutic MOFs for the delivery of bioactive molecules.
abstract: A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.
authors.affiliation: Institut Lavoisier, UMR CNRS 8180, University of Versailles-St. Quentin-en-Yvelines, 45, Avenue des Etats-Unis, 78035, Versailles, France.
authors.forename: Stuart R
authors.initials: SR
authors.lastname: Miller
authors.forename: Daniela
authors.initials: D
authors.lastname: Heurtaux
authors.forename: Tarek
authors.initials: T
authors.lastname: Baati
authors.forename: Patricia
authors.initials: P
authors.lastname: Horcajada
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Grenèche
authors.forename: Christian
authors.initials: C
authors.lastname: Serre
mesh_terms: D018360:Crystallography, X-Ray; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D007501:Iron / Q000737:chemistry*; D008958:Models, Molecular; D009525:Niacin / Q000737:chemistry*; D013696:Temperature
chemical_list: D005290:Ferric Compounds; D009525:Niacin; D007501:Iron