title: Histopathological evaluation of root canal filling materials for primary teeth.
abstract: This study aimed to assess the response of apical and periapical tissues of dogs' teeth after root canal filling with different materials. Forty roots from dogs' premolars were prepared biomechanically and assigned to 4 groups filled with: Group I: commercial calcium hydroxide and polyethylene glycol-based paste (Calen) thickened with zinc oxide; Group II: paste composed of iodoform, Rifocort and camphorated paramonochlorophenol; Group III: zinc oxide-eugenol cement; Group IV: sterile saline. After 30 days, the samples were subjected to histological processing. The histopathological findings revealed that in Groups I and IV the apical and periapical regions exhibited normal appearance, with large number of fibers and cells and no resorption of mineralized tissues. In Group II, mild inflammatory infiltrate and mild edema were observed, with discrete fibrogenesis and bone resorption. Group III showed altered periapical region and thickened periodontal ligament with presence of inflammatory cells and edema. It may be concluded that the Calen paste thickened with zinc oxide yielded the best tissue response, being the most indicated material for root canal filling of primary teeth with pulp vitality.
authors.affiliation: Department of Pediatric Clinics, Preventive and Community Dentistry, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Léa Assed Bezerra da
authors.initials: LA
authors.lastname: Silva
authors.forename: Mário Roberto
authors.initials: MR
authors.lastname: Leonardo
authors.forename: Daniela S B de
authors.initials: DS
authors.lastname: Oliveira
authors.forename: Raquel Assed Bezerra da
authors.initials: RA
authors.lastname: Silva
authors.forename: Alexandra Mussolino de
authors.initials: AM
authors.lastname: Queiroz
authors.forename: Patrícia Gatón
authors.initials: PG
authors.lastname: Hernández
authors.forename: Paulo
authors.initials: P
authors.lastname: Nelson-Filho
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000601:surgery; D001862:Bone Resorption / Q000209:etiology; D002126:Calcium Hydroxide / Q000627:therapeutic use; D002164:Camphor / Q000627:therapeutic use; D002733:Chlorophenols / Q000627:therapeutic use; D003238:Connective Tissue / Q000187:drug effects; D003739:Dental Cementum / Q000187:drug effects; D019551:Dental Disinfectants / Q000627:therapeutic use; D003786:Dental Pulp Cavity / Q000187:drug effects* / Q000473:pathology; D003804:Dentin / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004487:Edema / Q000209:etiology; D006847:Hydrocarbons, Iodinated / Q000627:therapeutic use; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008422:Materials Testing; D010486:Periapical Tissue / Q000187:drug effects / Q000473:pathology; D010513:Periodontal Ligament / Q000187:drug effects / Q000473:pathology; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D012294:Rifamycins / Q000627:therapeutic use; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D018915:Root Canal Preparation / Q000379:methods; D012391:Root Resorption / Q000209:etiology; D013997:Time Factors; D019227:Tooth Apex / Q000187:drug effects / Q000473:pathology; D014094:Tooth, Deciduous / Q000187:drug effects* / Q000473:pathology; D015034:Zinc Oxide / Q000627:therapeutic use; D015035:Zinc Oxide-Eugenol Cement / Q000627:therapeutic use
chemical_list: D002733:Chlorophenols; D019551:Dental Disinfectants; D004338:Drug Combinations; D006847:Hydrocarbons, Iodinated; D012294:Rifamycins; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C420643:calen; C541391:rifocort; D011092:Polyethylene Glycols; D002164:Camphor; C029804:camphorated parachlorophenol; D011239:Prednisolone; C010473:iodoform; D002126:Calcium Hydroxide; D015034:Zinc Oxide