title: Performance of CT colonography in clinical trials.
abstract: The amount of data accumulated in trials of CT colonography (CTC) has greatly increased in the past decade. The information from these studies is shaping clinical practice and public health policy regarding screening for colorectal cancer (CRC). This article examines the performance of CTC in clinical trials for individuals at average risk and increased risk for CRC. It also addresses the efficacy of CTC after incomplete colonoscopy, when colon preparations are reduced or eliminated, and in academic versus nonacademic environments. The data suggest that CTC is effective especially for the detection of larger lesions and when more advanced imaging technology is used.
authors.affiliation: Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637-1463, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Rosenberg
authors.forename: David T
authors.initials: DT
authors.lastname: Rubin
mesh_terms: D002986:Clinical Trials as Topic; D023881:Colonography, Computed Tomographic / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000379:methods; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014481:United States / Q000453:epidemiology