18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in rats.
18-Methoxycoronaridine (18-MC), a selective antagonist of alpha3beta4 nicotinic receptors, has been shown to reduce the self-administration of several drugs of abuse. Recently, this agent has also been shown to attenuate sucrose reward, decrease sucrose intake and prevent the development of sucrose-induced obesity in rats. The present experiments were designed to determine whether the latter effect was due to an 18-MC-induced conditioned taste aversion to sucrose. Both 18-MC (20mg/ kg, i.p.) and control agent, lithium chloride (100mg/kg, i.p.), reduced sucrose intake 24h after association with sucrose; however, only lithium chloride reduced sucrose intake 72h later. Consistent with previous data, 18-MC appears to have proactive effect for 24h and it does not induce a conditioned taste aversion.
Taraschenko
Olga D
OD
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA. tarasco@mail.amc.edu
Maisonneuve
Isabelle M
IM
Glick
Stanley D
SD
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D005260:Female; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018021:Lithium Chloride; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose; D013649:Taste / Q000187:drug effects*
D019440:Anti-Obesity Agents; D007050:Ibogaine; D013395:Sucrose; D018021:Lithium Chloride; C103345:18-methoxycoronaridine
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