title: G/R 241 polymorphism of intercellular adhesion molecule 1 (ICAM-1) is associated with Fuchs uveitis.
abstract: OBJECTIVE
  To investigate potential associations of the ICAM-1 gene polymorphisms and Fuchs uveitis in a cohort of Italian patients.
  
  
  METHODS
  Seventy-one consecutive Italian patients affected by Fuchs uveitis were observed at the Ocular Immunology Unit, Arcispedale S. Maria Nuova (Reggio Emilia, Italy) from 2002 to 2008. Two hundred twenty-six healthy Italian blood donors from the same geographic area were selected as the control group. All Fuchs uveitis patients and control subjects were genotyped by polymerase chain reaction (PCR) and allele-specific oligonucleotide techniques for ICAM-1 polymorphisms at codon 241 (exon 4).
  
  
  RESULTS
  The frequency of the ICAM-1 G/R 241 polymorphism was significantly higher in Fuchs uveitis than in the control subjects (16.9% vs. 5.8%; P=0.006, Pcorr=0.012; odds ratio, 3.3; 95% confidence interval, 1.4-7.7). No significant association between clinical features and ICAM-1 polymorphisms was found.
  
  
  CONCLUSIONS
  This study demonstrates for the first time that the ICAM-1 G/R 241 polymorphism may represent a candidate gene for Fuchs uveitis susceptibility.
authors.affiliation: Ocular Immunology Unit, Arcispedale S Maria Nuova REggion emilia, Italy. l.cimono@libero.it
authors.forename: Luca
authors.initials: L
authors.lastname: Cimino
authors.forename: Luigi
authors.initials: L
authors.lastname: Boiardi
authors.forename: Raffaella
authors.initials: R
authors.lastname: Aldigeri
authors.forename: Bruno
authors.initials: B
authors.lastname: Casali
authors.forename: Davide
authors.initials: D
authors.lastname: Nicoli
authors.forename: Enrico
authors.initials: E
authors.lastname: Farnetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Salvarani
authors.forename: Daniele
authors.initials: D
authors.lastname: Cirone
authors.forename: Liberatina
authors.initials: L
authors.lastname: De Martino
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pupino
authors.forename: Luca
authors.initials: L
authors.lastname: Cappuccini
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007558:Italy; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014606:Uveitis, Anterior / Q000235:genetics*
chemical_list: D018799:Intercellular Adhesion Molecule-1