[Androgen receptor CAG gene polymorphism in men with azoospermia and oligozoospermia in Ukraine].
The number of CAG repeats of exon 1 of AR gene was determined in a group of 228 infertile males with azoospermia (n = 68) and oligozoospermia (n = 160) as well as in control group (124 proven fathers) by fluorescent polymerase chain reaction amplification followed by fragment analysis on automated fluorescent analyzer "A.L.F-express". The frequency of alleles with GAG-repeats < or = 18 was significantly higher (P < 0,01) in the group of patients with azoospermia (17,7%) comparing with the control group (2,4%) as well as in the group of patients with oligozoospermia (12,5%) comparing with the control group (2,4%). The frequency of alleles with CAG-repeats > or = 28 significantly differed (P < 0,01) between the group of patients with oligozoospermia (12,5%) and the control group (2,4%). Our data suggest an association between CAG repeats number and impaired spermatogenesis in azoospermic and oligozoospermic males.
Fesaĭ
O A
OA
Kravchenko
S A
SA
Tyrkus
M Ia
MIa
Makukh
G V
GV
Zinchenko
V M
VM
Strelko
G V
GV
Livshits
L A
LA
D053713:Azoospermia / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D013091:Spermatogenesis / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics*; D014455:Ukraine
D011944:Receptors, Androgen