title: Replacement of the condyle and ascending ramus by a modular endoprosthesis in Macaca fascicularis--part 3: evaluation of peri-implant bone remodeling.
abstract: OBJECTIVE
  To assess whether the fixation of a condyle-ascending ramus mandibular modular endoprosthesis, using bone cement, will result in stress-related bone resorption in the Macaca fascicularis.
  
  
  METHODS
  The right condyle and ascending ramus were resected in 8 adult monkeys and replaced by a modular endoprosthesis, fixed with polymethylmethacrylate bone cement (Palacos). Four monkeys were sacrificed at 3 months and another 4 at 6 months postoperatively. The bone mineral density was assessed using dual-energy x-ray absorptiometry in the region anterior to the stem and using micro-computed tomography in the buccal, lingual, and inferior regions adjacent to the stem.
  
  
  RESULTS
  The bone mineral density of the 3-month specimens was greater than that at 6 months in the buccal, lingual, and inferior regions adjacent to the stem. However, the difference was statistically significant only in the inferior aspect. No significant difference was found in the bone mineral density in the region anterior to the stem between the 3- and 6-month specimens.
  
  
  CONCLUSIONS
  A minimal reduction in bone density around the stem of the endoprosthesis was observed between 3 and 6 months after placement. This reduction did not result in any adverse clinical events.
authors.affiliation: Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore, Singapore. gohbee@starhub.net.sg
authors.forename: Bee Tin
authors.initials: BT
authors.lastname: Goh
authors.forename: Shermin
authors.initials: S
authors.lastname: Lee
authors.forename: Henk
authors.initials: H
authors.lastname: Tideman
authors.forename: Paul J W
authors.initials: PJ
authors.lastname: Stoelinga
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001843:Bone Cements; D015519:Bone Density; D016723:Bone Remodeling; D002484:Cementation; D008252:Macaca fascicularis; D008297:Male; D008334:Mandible / Q000601:surgery*; D008335:Mandibular Condyle / Q000601:surgery; D008341:Mandibular Prosthesis; D019904:Polymethyl Methacrylate; D011474:Prosthesis Design; D016059:Range of Motion, Articular; D055114:X-Ray Microtomography
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate