The frequency of occurrence and nature of recombinant feline leukemia viruses in the induction of multicentric lymphoma by infection of the domestic cat with FeLV-945.
During feline leukemia virus (FeLV) infection in the domestic cat, viruses with a novel envelope gene arise by recombination between endogenous FeLV-related elements and the exogenous infecting species. These recombinant viruses (FeLV-B) are of uncertain disease association, but have been linked to the induction of thymic lymphoma. To assess the role of FeLV-B in the induction of multicentric lymphoma and other non-T-cell disease, the frequency of occurrence and nature of FeLV-B were examined in diseased tissues from a large collection of FeLV-infected animals. Diseased tissues were examined by Southern blot and PCR amplification to detect the presence of FeLV-B. Further analysis was performed to establish the recombination junctions and infectivity of FeLV-B in diseased tissues. The results confirmed the frequent association of FeLV-B with thymic lymphoma but showed infrequent generation, low levels and lack of infectivity of FeLV-B in non-T-cell diseases including multicentric lymphoma.
Ahmad
Shamim
S
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. sahmad1@tulane.edu
Levy
Laura S
LS
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002371:Cat Diseases / Q000473:pathology / Q000821:virology*; D002415:Cats; D005256:Leukemia Virus, Feline / Q000235:genetics* / Q000302:isolation & purification* / Q000472:pathogenicity; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D016415:Sequence Alignment; D014759:Viral Envelope Proteins / Q000235:genetics*
D014759:Viral Envelope Proteins
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