title: Is there evidence of separate inflammatory or metabolic forms of preeclampsia?
abstract: OBJECTIVE
  To examine whether high insulin resistance versus high inflammation identifies subtypes of preeclampsia.
  
  
  METHODS
  A cytokine panel, glucose and insulin were measured in 37 preeclampsia plasma samples. Wilcoxon rank sum assessed median concentration of HOMA(IR) by pro-inflammatory:anti-inflammatory ratio. Regression stratifying by BMI and preterm birth was conducted.
  
  
  RESULTS
  There was no difference in median HOMA(IR) by the pro-inflammatory:anti-inflammatory ratio (p = 0.16). No subsets scatterplot clusters emerged. A positive correlation between HOMAlog and the ratio was significant (p = 0.04).
  
  
  CONCLUSIONS
  No dichotomous subsets of preeclampsia by inflammation versus insulin resistance were detected. Contrary to our hypothesis, insulin resistance was higher as inflammation increased in preeclampsia.
authors.affiliation: School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. foundss@pitt.edu
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Founds
authors.forename: Janet M
authors.initials: JM
authors.lastname: Catov
authors.forename: Marcia J
authors.initials: MJ
authors.lastname: Gallaher
authors.forename: Gail F
authors.initials: GF
authors.lastname: Harger
authors.forename: Nina
authors.initials: N
authors.lastname: Markovic
authors.forename: James M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D011225:Pre-Eclampsia / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin
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