The spatial arrangement of the human large intestinal wall blood circulation.
The aim of the study was to describe and depict the spatial arrangement of the colon microcirculatory bed as a whole. Various parts of the large intestine and terminal ileum were harvested from either cadaver or section material or gained peroperatively. Samples were then injected with India ink or methylmetacrylate Mercox resin for microdissection and corrosion casting for scanning electron microscopy. The results showed that extramural vasa recta ramified to form the subserous plexus, some of them passing underneath the colon taeniae. Branches of both short and long vasa recta merged in the colon wall, pierced the muscular layer and spread out as the submucous plexus, which extended throughout the whole intestine without any interruption. The muscular layer received blood via both the centrifugal branches of the submucous plexus and the minor branches sent off by the subserous plexus. The mucosa was supplied by the mucous plexus, which sent capillaries into the walls of intestinal glands. The hexagonal arrangement of the intestinal glands reflected their vascular bed. All three presumptive critical points are only gross anatomical points of no physiological relevance in healthy individuals. Neither microscopic weak points nor regional differences were proven within the wall of the whole large intestine. The corrosion casts showed a huge density of capillaries under the mucosa of the large intestine. A regular hexagonal pattern of the vascular bed on the inner surface was revealed. No microvascular critical point proofs were confirmed and a correlation model to various pathological states was created.
Kachlik
David
D
Third Faculty of Medicine, Charles University in Prague, Ruská, Praha, Czech Republic. david.kachlik@lf3.cuni.cz
Baca
Vaclav
V
Stingl
Josef
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000648:ultrastructure*; D002102:Cadaver; D016319:Corrosion Casting; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply*; D007420:Intestine, Large / Q000098:blood supply / Q000648:ultrastructure*; D008297:Male; D008833:Microcirculation; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D055815:Young Adult
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