title: HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients.
abstract: The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobels vag 16, 17177 Stockholm, Sweden. helena.skar@smi.se
authors.forename: Helena
authors.initials: H
authors.lastname: Skar
authors.forename: Pedro
authors.initials: P
authors.lastname: Borrego
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Wallstrom
authors.forename: Mattias
authors.initials: M
authors.lastname: Mild
authors.forename: José Maria
authors.initials: JM
authors.lastname: Marcelino
authors.forename: Helena
authors.initials: H
authors.lastname: Barroso
authors.forename: Nuno
authors.initials: N
authors.lastname: Taveira
authors.forename: Thomas
authors.initials: T
authors.lastname: Leitner
authors.forename: Jan
authors.initials: J
authors.lastname: Albert
mesh_terms: D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D015658:HIV Infections / Q000235:genetics / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity; D015498:HIV-2 / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D012641:Selection, Genetic; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D004279:DNA, Viral; D054299:env Gene Products, Human Immunodeficiency Virus
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