Associations of ATGL gene polymorphisms with chicken growth and fat traits.
Adipose triglyceride lipase (ATGL) catalyses the initial step in triglyceride hydrolysis, so the ATGL gene is a candidate for growth and fat traits in chickens. Nine reported single-nucleotide polymorphisms (SNPs) located in 3 exons of the chicken ATGL gene were chosen for genotyping an F2 population. Only 5 SNPs were confirmed for polymorphisms and used for association analyses. The results show that c.531G>A (p.E177Syn) was not associated with any growth and fat traits (P > 0.05), but c.782G>A (p.S261N) was associated with body weight (BW) on days 14, 21, 35, 63, 70, 77, cingulated fat width and abdominal fat pad weight (P < 0.05), and significantly associated with BW on days 42, 49, and 56 (P < 0.01). Significant associations of c.903C>T (p.F301Syn) with BW on days 49 and 77 days and crude protein content of breast muscle (P < 0.05), and c.1164G>A (p.K388Syn) with BW on day 7 (P < 0.05) were also detected. Additionally, c.1069T>C (p.L357Syn) was associated with breast muscle colour (P < 0.05), and significantly associated with crude fat (ether extract) content of breast muscle (P < 0.01). Thus the missense SNP of c.782G>A (p.S261N) was significantly associated with the largest number of chicken growth and fat traits in this study.
Nie
Q-H
QH
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Fang
M-X
MX
Xie
L
L
Shen
X
X
Liu
J
J
Luo
Z-P
ZP
Shi
J-J
JJ
Zhang
X-Q
XQ
D000273:Adipose Tissue / Q000033:anatomy & histology*; D000818:Animals; D001835:Body Weight / Q000235:genetics; D002645:Chickens / Q000235:genetics* / Q000254:growth & development; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D008049:Lipase / Q000235:genetics*; D008297:Male; D016366:Open Reading Frames; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers; D008049:Lipase
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