title: Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue?
abstract: The aims of this study is to evaluate the presence of estrogen receptors alpha (ERα) in thyroid lesions and to assess the practicality of this test in view of numerous disagreements on the subject. Immunohistochemical stains were performed for ERα, for the evaluation of immunoreactivity in 296 pathological thyroid tissue samples. We evaluated the intensity of the nuclear and cytoplasmatic staining and the spread of the stain over the sample. Thirty cases of the breast cancer served as a control group. None of the histological thyroid samples showed immunoreactivity for ERα. No difference was found between the various lesions in regard to this absence. The ERα rate of expression in the breast cancer samples was 60%. The ERα is undetectable in the histological samples of benign and malignant thyroid lesions. Further investigation is necessary in the laboratory immunohistochemical workup in order to exclude a possibility of non-specific staining.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Assaf HaRofeh Medical Center affiliated to Sackler Medical School, Tel-Aviv University, Zerifin, Israel. vaimed@yahoo.com
authors.forename: Michael
authors.initials: M
authors.lastname: Vaiman
authors.forename: Youlian
authors.initials: Y
authors.lastname: Olevson
authors.forename: Judith
authors.initials: J
authors.lastname: Sandbank
authors.forename: Liliana
authors.initials: L
authors.lastname: Habler
authors.forename: Sergei
authors.initials: S
authors.lastname: Zehavi
authors.forename: Alex
authors.initials: A
authors.lastname: Kessler
mesh_terms: D000328:Adult; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D013965:Thyroidectomy
chemical_list: D047628:Estrogen Receptor alpha
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