Male-only systemic lupus.
OBJECTIVE
Systemic lupus erythematosus (SLE) is more common among women than men, a ratio of about 10 to 1. We undertook this study to describe familial male SLE within a large familial SLE cohort.


METHODS
SLE families (2 or more patients) were identified from the Lupus Multiplex Registry and Repository. Genomic DNA and blood samples were obtained using standard methods. Autoantibodies were determined by multiple methods. Medical records were abstracted for SLE clinical data. Fluorescent in situ hybridization (FISH) was performed with X and Y centromere-specific probes, and a probe specific for the Toll-like receptor 7 gene on the X chromosome.


RESULTS
Among 523 SLE families, we found 5 families in which all the SLE patients were male. FISH found no yaa gene equivalent in these families. SLE-unaffected primary female relatives from the 5 families with only-male SLE patients had a statistically increased rate of positive antinuclear antibodies compared to SLE-unaffected female relatives in other families. White men with SLE were 5 times more likely to have an offspring with SLE than White women with SLE, but there was no difference in this likelihood among Black men.


CONCLUSIONS
Because women in the all-male families had positive antinuclear antibodies, and men are more likely to have children with SLE, these data suggest genetic susceptibility factors that act only in men.
Aggarwal
Rachna
R
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Rachna-aggarwal@omrf.ouhsc.edu.
Namjou
Bahram
B
Li
Shibo
S
D'Souza
Anil
A
Tsao
Betty P
BP
Bruner
Benjamin F
BF
James
Judith A
JA
Scofield
R Hal
RH
D001741:Black or African American / Q000235:genetics; D000974:Antibodies, Antinuclear / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000235:genetics; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000235:genetics*; D008297:Male; D010375:Pedigree; D012042:Registries; D044465:White People / Q000235:genetics
D000974:Antibodies, Antinuclear; D001323:Autoantibodies
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