[Treatment of adult patients with metastatic sarcoma: current shift in concepts].
We describe herein the current concepts tested in clinical trials dedicated to patients with metastatic soft tissue sarcomas: identify predictive factors under anthracyclin-based regimens, identify patients beneficing from polychemotherapy, benefit of maintenance treatment, use of non-progression rate rather than response rate for selecting new drugs, histology-tailored or biological target-tailored second-line treatment.
Penel
N
N
Centre Oscar-Lambret, Département de cancérologie générale, 3, rue F.-Combemale, 59020 Lille, France.
Watelle
F
F
Vanhuyse
M
M
Adenis
A
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology
C515074:ridaforolimus; D004317:Doxorubicin; D020123:Sirolimus