title: [Intratympanic glucocorticoid therapy of sudden hearing loss].
abstract: In addition to the intratympanic application of gentamycin for the therapy of Menière's disease, therapy of sudden hearing loss with glucocorticoids has received steadily growing interest especially in the last 15 years. Various aspects favor local therapy of inner ear diseases, such as bypassing of the blood-labyrinth barrier and achieving higher inner ear drug levels. However, for local application special pharmacokinetic aspects must be taken into consideration in comparison to systemic application. Among the rapidly growing number of reports on local therapy of sudden hearing loss there are, however, only few which included control groups and an even fewer number of prospective randomized clinical studies. The case series and clinical studies differ in the glucocorticoid studied, the application system used and the mode of application as primary therapy or as secondary therapy following unsuccessful systemic application. Although both the number of clinical studies with sufficient quality as well as the total number of patients treated in the published studies are still low, intratympanic application of glucocorticosteroids seems in principal to be a good approach for secondary therapy of patients following unsuccessful systemic treatment.
authors.affiliation: Klinik für Hals,-Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Tübingen, Elfriede-Aulhorn-Str 5, 72076 Tübingen. Stefan.Plontke@uni-tuebingen.de
authors.forename: S K
authors.initials: SK
authors.lastname: Plontke
mesh_terms: D005938:Glucocorticoids / Q000008:administration & dosage*; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome; D014432:Tympanic Membrane
chemical_list: D005938:Glucocorticoids
references.citation: Hear Res. 1999 Oct;136(1-2):124-30
references.pmid: 10511631
references.citation: Otolaryngol Head Neck Surg. 2006 Jun;134(6):940-5
references.pmid: 16730534
references.citation: HNO. 2001 Jul;49(7):538-42
references.pmid: 11486587
references.citation: Otol Neurotol. 2008 Apr;29(3):401-6
references.pmid: 18277312
references.citation: Otol Neurotol. 2001 Jul;22(4):475-9
references.pmid: 11449103
references.citation: Otolaryngol Head Neck Surg. 2005 Jun;132(6):902-5
references.pmid: 15944562
references.citation: Laryngoscope. 2009 Feb;119(2):359-69
references.pmid: 19172627
references.citation: Laryngoscope. 2008 Feb;118(2):279-82
references.pmid: 17989574
references.citation: Otol Neurotol. 2005 Sep;26(5):878-81
references.pmid: 16151332
references.citation: Otol Neurotol. 2009 Feb;30(2):254-5; author reply 255-6
references.pmid: 18849885
references.citation: Otolaryngol Head Neck Surg. 2007 Jul;137(1):74-8
references.pmid: 17599569
references.citation: Laryngoscope. 2004 Jul;114(7):1184-9
references.pmid: 15235345
references.citation: Otol Neurotol. 2001 Jan;22(1):18-23
references.pmid: 11314710
references.citation: Otol Neurotol. 2010 Jan;31(1):25-30
references.pmid: 19940792
references.citation: Acta Otolaryngol. 2002 Oct;122(7):698-702
references.pmid: 12484644
references.citation: Audiol Neurootol. 2009;14(6):373-82
references.pmid: 19923807
references.citation: ORL J Otorhinolaryngol Relat Spec. 2006;68(5):247-52
references.pmid: 16679810
references.citation: Acta Otolaryngol. 2005 Aug;125(8):830-9
references.pmid: 16158529
references.citation: Audiol Neurootol. 2005 Jan-Feb;10(1):53-63
references.pmid: 15591792
references.citation: Eur Arch Otorhinolaryngol. 2005 Feb;262(2):131-4
references.pmid: 15747106
references.citation: Laryngoscope. 1999 Jul;109(7 Pt 2):1-17
references.pmid: 10399889
references.citation: Acta Otolaryngol. 2007 Oct;127(10):1012-7
references.pmid: 17851934
references.citation: Otol Neurotol. 2006 Aug;27(5):604-8
references.pmid: 16788418
references.citation: Otol Neurotol. 2005 Sep;26(5):890-5
references.pmid: 16151334
references.citation: Adv Otorhinolaryngol. 2002;59:149-55
references.pmid: 11887794
references.citation: Otolaryngol Head Neck Surg. 2001 Sep;125(3):142-6
references.pmid: 11555744
references.citation: Otolaryngol Head Neck Surg. 2006 Aug;135(2):276-9
references.pmid: 16890082
references.citation: Laryngoscope. 2006 May;116(5):747-52
references.pmid: 16652082
references.citation: Laryngoscope. 2007 Jan;117(1):3-15
references.pmid: 17202923
references.citation: Ear Nose Throat J. 1996 Aug;75(8):468-71, 474, 476 passim
references.pmid: 8828271
references.citation: Audiol Neurootol. 2009;14(6):350-60
references.pmid: 19923805
references.citation: Otolaryngol Head Neck Surg. 2009 Nov;141(5):572-8
references.pmid: 19861193
references.citation: Otolaryngol Head Neck Surg. 2005 Aug;133(2):251-9
references.pmid: 16087024
references.citation: Ann Otol Rhinol Laryngol. 2000 Jan;109(1):30-2
references.pmid: 10651408
references.citation: Otol Neurotol. 2007 Dec;28(8):1124-30
references.pmid: 18043438
references.citation: Otol Neurotol. 2007 Apr;28(3):312-6
references.pmid: 17414035
references.citation: Otolaryngol Head Neck Surg. 2005 Apr;132(4):527-31
references.pmid: 15806039
references.citation: Otol Neurotol. 2008 Jun;29(4):453-60
references.pmid: 18401285
references.citation: J Control Release. 2005 Dec 10;110(1):1-19
references.pmid: 16274830
references.citation: J Assoc Res Otolaryngol. 2006 Jun;7(2):182-93
references.pmid: 16718612
references.citation: Eur Arch Otorhinolaryngol. 2005 Jul;262(7):587-91
references.pmid: 15744509
references.citation: Otol Neurotol. 2008 Aug;29(5):732-3; author reply 733
references.pmid: 18451748