Nonsteroidal anti-inflammatory drug-associated renal papillary necrosis in a white-tailed deer (Odocoileus virginianus).
Renal papillary necrosis was diagnosed during postmortem examination of a juvenile white-tailed deer (Odocoileus virginianus) from Oklahoma. The deer was surgically treated for a Salter Harris type II fracture of the proximal tibia of the left hind limb. The animal was administered multiple nonsteroidal anti-inflammatory drugs (NSAIDs), including meloxicam, flunixin meglumine, and ketoprofen for pain management. At postmortem examination, gross lesions included a proximal tibial Salter Harris type II fracture with an associated fibrinonecrotizing myositis and bilateral renal papillary necrosis. Histologically, the kidneys exhibited coagulation necrosis of the renal medulla and renal papilla, thrombosis of renal blood vessels, and interstitial medullary edema. The gross and microscopic lesion coupled with the clinical history of multiple NSAID administration suggests NSAID-induced renal papillary necrosis.
Stern
Adam W
AW
Department of Pathobiology, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA. Adam.stern@okstate.edu
Ritchey
Jerry W
JW
Hall
Brittany
B
Ketz-Riley
Cornelia J
CJ
Genova
Suzanne G
SG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003238:Connective Tissue / Q000473:pathology; D003670:Deer; D017809:Fatal Outcome; D005260:Female; D006762:Hospitals, Animal; D006784:Hospitals, Teaching; D007660:Ketoprofen / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D009825:Oklahoma; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary; D011180:Postmortem Changes; D013978:Tibial Fractures / Q000150:complications / Q000662:veterinary
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen