Patient-specific early seizure detection from scalp electroencephalogram.
The objective of this study is to develop a method for automatic detection of seizures before or immediately after clinical onset using features derived from scalp electroencephalogram. This detection method is patient specific. It uses recurrent neural networks and a variety of input features. For each patient, we trained and optimized the detection algorithm for two cases: (1) during the period immediately preceding seizure onset and (2) during the period immediately after seizure onset. Continuous scalp electroencephalogram recordings (duration 15-62 hours, median 25 hours) from 25 patients, including a total of 86 seizures, were used in this study. Preonset detection was successful in 14 of the 25 patients. For these 14 patients, all of the testing seizures were detected before seizure onset with a median preonset time of 51 seconds and false-positive (FP) rate was 0.06/hour. Postonset detection had 100% sensitivity, 0.023/hour FP rate, and median delay of 4 seconds after onset. The unique results of this study relate to preonset detection. Our results suggest that reliable preonset seizure detection may be achievable for a significant subset of patients with epilepsy without use of invasive electrodes.
Minasyan
Georgiy R
GR
Chatten Associates, Inc, West Conshohocken, Pennsylvania, USA. gminasyan@chattenassociates.com
Chatten
John B
JB
Chatten
Martha J
MJ
Harner
Richard N
RN
D000328:Adult; D000465:Algorithms; D001931:Brain Mapping; D004569:Electroencephalography; D001330:Electronic Data Processing / Q000379:methods; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012535:Scalp / Q000503:physiopathology*; D012640:Seizures / Q000175:diagnosis*; D013997:Time Factors; D055815:Young Adult
IEEE Trans Biomed Eng. 2003 May;50(5):616-27
12769437
Neuron. 2001 Apr;30(1):51-64
11343644
Electroencephalogr Clin Neurophysiol. 1998 Jun;106(6):513-21
9741751
Electroencephalogr Clin Neurophysiol. 1991 Jul;79(1):11-9
1713547
Comput Biol Med. 2007 Feb;37(2):227-44
16480706
Conf Proc IEEE Eng Med Biol Soc. 2005;2005:3546-50
17280990
Epilepsy Behav. 2008 Jan;12(1):128-35
18086457
Curr Opin Neurol. 2006 Apr;19(2):187-93
16538095
IEEE Trans Neural Netw. 1994;5(4):537-50
18267827
Electroencephalogr Clin Neurophysiol. 1982 Nov;54(5):530-40
6181976
Brain. 2005 Aug;128(Pt 8):1811-7
15975948
IEEE Trans Biomed Eng. 1998 Oct;45(10):1205-16
9775534
Clin Neurophysiol. 2005 Aug;116(8):1785-95
16005680
Epilepsia. 2002 Dec;43(12):1522-35
12460255
IEEE Trans Biomed Eng. 1997 Feb;44(2):115-22
9214791
Electroencephalogr Clin Neurophysiol. 1979 May;46(5):510-20
88339
Epilepsy Behav. 2004 Aug;5(4):483-98
15256184
Clin Neurophysiol. 2005 Feb;116(2):427-42
15661120
Clin Electroencephalogr. 2000 Oct;31(4):181-91
11056840
Arch Neurol. 1978 May;35(5):276-86
417703
Electroencephalogr Clin Neurophysiol. 1976 Nov;41(5):513-29
61855
IEEE Trans Biomed Eng. 2003 May;50(5):584-93
12769434
Clin Neurophysiol. 2003 May;114(5):898-908
12738437
Brain. 2007 Feb;130(Pt 2):314-33
17008335
J Clin Neurophysiol. 2008 Jun;25(3):119-31
18469727
J Clin Neurophysiol. 1999 Mar;16(2):141-5
10359499
Clin Neurophysiol. 2008 Jan;119(1):197-211
18037341
IEEE Trans Biomed Eng. 2003 May;50(5):603-15
12769436
IEEE Trans Biomed Eng. 2003 May;50(5):549-58
12769431
Lancet Neurol. 2002 May;1(1):22-30
12849542
Clin Neurophysiol. 2005 Oct;116(10):2460-72
16125459
Clin Neurophysiol. 2009 Aug;120(8):1465-78
19576849
Epilepsia. 1998 Jun;39(6):615-27
9637604
Epilepsia. 2003;44 Suppl 12:72-83
14641563
J Clin Neurophysiol. 2001 May;18(3):191-208
11528293
Neurology. 1995 Dec;45(12):2250-4
8848202