title: Infliximab administration reduces neuronal apoptosis on the optic pathways in a rabbit hydrocephalus model: a preliminary report.
abstract: OBJECTIVE
  This study was designed to explore the effects of infliximab on the optic pathway in kaolin induced hydrocephalus rabbit model.
  
  
  METHODS
  After injection of kaolin to the cisterna magna of 12 New Zealand rabbits for induction of hydrocephalus, animals were divided into 2 groups and received either infliximab or normal saline. The intracranial pressure measurement was performed 2 times; firstly, before kaolin injection and secondly, before decapitation to ensure that the rabbits had hydrocephalus. After 2 weeks, animals were decapitated.
  
  
  RESULTS
  Apoptotic cells in the lateral geniculate body, optic radiation, and optic disc were counted with TUNEL method. Apoptotic cell counts of the lateral geniculate body and the optic radiation were showed statistically significant difference between the infliximab group and the control group.
  
  
  CONCLUSIONS
  This study suggests that infliximab may have a neuroprotective effect through its anti-apoptotic property on hydrocephalus induced optic pathways injury.
authors.affiliation: Department of Neurosurgery, Gazi University, Ankara, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kurt
authors.forename: Berker
authors.initials: B
authors.lastname: Cemil
authors.forename: Alp Ozgun
authors.initials: AO
authors.lastname: Borcek
authors.forename: Pelin
authors.initials: P
authors.lastname: Borcek
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyurek
authors.forename: Aylin
authors.initials: A
authors.lastname: Sepici
authors.forename: Necdet
authors.initials: N
authors.lastname: Ceviker
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002452:Cell Count / Q000379:methods; D004195:Disease Models, Animal; D005829:Geniculate Bodies / Q000187:drug effects* / Q000473:pathology; D006849:Hydrocephalus / Q000139:chemically induced / Q000473:pathology*; D000069285:Infliximab; D007427:Intracranial Pressure / Q000187:drug effects* / Q000502:physiology; D007616:Kaolin; D008297:Male; D011817:Rabbits; D014795:Visual Pathways / Q000187:drug effects* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D007616:Kaolin; D000069285:Infliximab