Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging.
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), performed (11)C-Pittsburgh Compound B (PiB) scans in 177 healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients. High PiB binding was present in 33% of HC (49% in ApoE-epsilon4 carriers vs 21% in noncarriers) and increased with age, most strongly in epsilon4 carriers. 18% of HC aged 60-69 had high PiB binding rising to 65% in those over 80 years. Subjective memory complaint was only associated with elevated PiB binding in epsilon4 carriers. There was no correlation with cognition in HC or MCI. PiB binding in AD was unrelated to age, hippocampal volume or memory. Beta-amyloid (Abeta) deposition seems almost inevitable with advanced age, amyloid burden is similar at all ages in AD, and secondary factors or downstream events appear to play a more direct role than total beta amyloid burden in hippocampal atrophy and cognitive decline.
Rowe
Christopher C
CC
Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia. Christopher.Rowe@austin.org.au
Ellis
Kathryn A
KA
Rimajova
Miroslava
M
Bourgeat
Pierrick
P
Pike
Kerryn E
KE
Jones
Gareth
G
Fripp
Jurgen
J
Tochon-Danguy
Henri
H
Morandeau
Laurence
L
O'Keefe
Graeme
G
Price
Roger
R
Raniga
Parnesh
P
Robins
Peter
P
Acosta
Oscar
O
Lenzo
Nat
N
Szoeke
Cassandra
C
Salvado
Olivier
O
Head
Richard
R
Martins
Ralph
R
Masters
Colin L
CL
Ames
David
D
Villemagne
Victor L
VL
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D001315:Australia / Q000453:epidemiology; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D017352:Echo-Planar Imaging; D005260:Female; D006580:Genetic Carrier Screening; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011446:Prospective Studies; D040242:Risk Reduction Behavior; D013844:Thiazoles / Q000378:metabolism
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D015415:Biomarkers; D013844:Thiazoles