title: Copper-mediated aerobic oxidative trifluoromethylation of terminal alkynes with Me3SiCF3.
abstract: An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me(3)SiCF(3)) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO(2)Et, -Br, and -NO(2) were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Chu
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing
mesh_terms: D000332:Aerobiosis; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D008745:Methylation; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D017655:Silicon Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D017655:Silicon Compounds; D005461:Fluorine; D003300:Copper; D010100:Oxygen