Small artery structure and function in hypertension.
It has been known for some considerable time that sustained hypertension changes the circulatory architecture both in the heart and blood vessels. The histopathological alterations are of considerable interest because once they have developed they appear to carry an adverse prognostic risk. In the heart it is apparent that there is hypertrophy. This extends also to the large- and medium-sized blood vessels but at the level of the smaller arteries that contribute to vascular resistance, this is not the case: it is clear that the physiological response to higher pressures is a change in the positional conformation of the pre-existing tissue constituents and as a result of this the lumen is narrowed. This brief review looks at our knowledge in this area and attempts to clarify our understanding of how hypertension brings these about and what happens when these homeostatic mechanisms break down. From a therapeutic perspective it appears imperative to control blood pressure in an attempt to reverse or prevent such alterations to cardiovascular structure. Our knowledge is fast expanding in this field and it is only to be anticipated that as detection methodology improves everyday practice will alter as we profile our patients in terms of structural alterations in the ventricle and blood vessels.
Heagerty
Anthony M
AM
Cardiovascular Research Group, School of Biomedicine, The University of Manchester, Manchester, UK. tony.heagerty@manchester.ac.uk
Heerkens
Egidius H
EH
Izzard
Ashley S
AS
D001158:Arteries / Q000473:pathology* / Q000503:physiopathology*; D001775:Blood Circulation / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D006984:Hypertrophy
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