title: Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling.
abstract: The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C-H/C-OH bond activations with direct C(sp(2))-C(sp) bond formation, which is in line with ideal synthesis using readily available materials.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA. fkang@its.jnj.com
authors.forename: Fu-An
authors.initials: FA
authors.lastname: Kang
authors.forename: James C
authors.initials: JC
authors.lastname: Lanter
authors.forename: Chaozhong
authors.initials: C
authors.lastname: Cai
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sui
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D009943:Organophosphorus Compounds; D010165:Palladium; D003300:Copper