title: Rab GEFs and GAPs.
abstract: Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in.
authors.affiliation: University of Liverpool, Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK. fabarr@liverpool.ac.uk
authors.forename: Francis
authors.initials: F
authors.lastname: Barr
authors.forename: David G
authors.initials: DG
authors.lastname: Lambright
mesh_terms: D000818:Animals; D004705:Endocytosis; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D055571:Secretory Pathway; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D020691:rab GTP-Binding Proteins
references.citation: J Cell Biol. 2008 Nov 3;183(3):499-511
references.pmid: 18981233
references.citation: Nat Struct Mol Biol. 2007 May;14(5):406-12
references.pmid: 17450153
references.citation: Mol Biol Cell. 1997 Jul;8(7):1305-16
references.pmid: 9243509
references.citation: Nature. 2006 Jul 20;442(7100):303-6
references.pmid: 16855591
references.citation: J Biol Chem. 1997 Feb 14;272(7):3875-8
references.pmid: 9020086
references.citation: Mol Cell. 2007 Feb 9;25(3):455-62
references.pmid: 17289591
references.citation: EMBO J. 1999 Oct 1;18(19):5216-25
references.pmid: 10508155
references.citation: Nat Cell Biol. 2002 Feb;4(2):124-33
references.pmid: 11788822
references.citation: Biochem Biophys Res Commun. 2008 Jul 18;372(1):162-7
references.pmid: 18477474
references.citation: Structure. 2008 Oct 8;16(10):1478-90
references.pmid: 18940604
references.citation: Nature. 1993 Feb 25;361(6414):736-9
references.pmid: 8441469
references.citation: Biol Chem. 2000 May-Jun;381(5-6):453-6
references.pmid: 10937877
references.citation: Nature. 2010 Apr 1;464(7289):778-82
references.pmid: 20305638
references.citation: Biochim Biophys Acta. 2003 Aug 18;1641(2-3):71-85
references.pmid: 12914949
references.citation: J Mol Biol. 2000 Aug 25;301(4):1077-87
references.pmid: 10966806
references.citation: Eur J Biochem. 1999 Feb;260(1):284-90
references.pmid: 10091609
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14185-6
references.pmid: 19706500
references.citation: EMBO J. 2010 Jan 20;29(2):496-504
references.pmid: 19942850
references.citation: Proc Natl Acad Sci U S A. 2007 May 15;104(20):8305-10
references.pmid: 17488829
references.citation: Cell. 2007 Jun 15;129(6):1201-13
references.pmid: 17574030
references.citation: J Cell Sci. 2007 Sep 1;120(Pt 17):2997-3010
references.pmid: 17684057
references.citation: Science. 1997 Jul 18;277(5324):333-8
references.pmid: 9219684
references.citation: Mol Cell. 2009 Dec 25;36(6):1060-72
references.pmid: 20064470
references.citation: Neuron. 1997 Apr;18(4):613-22
references.pmid: 9136770
references.citation: Trends Biochem Sci. 1997 Jul;22(7):243-4
references.pmid: 9255064
references.citation: Development. 2009 Jul;136(14):2445-55
references.pmid: 19542357
references.citation: Cell Metab. 2007 Jan;5(1):59-72
references.pmid: 17189207
references.citation: Nat Rev Mol Cell Biol. 2004 Nov;5(11):886-96
references.pmid: 15520808
references.citation: Nature. 2003 Dec 4;426(6966):525-30
references.pmid: 14654833
references.citation: Structure. 2007 Feb;15(2):245-52
references.pmid: 17292842
references.citation: Nat Cell Biol. 2006 Sep;8(9):971-7
references.pmid: 16906144
references.citation: J Biol Chem. 2008 Aug 22;283(34):23209-16
references.pmid: 18559336
references.citation: Mol Cell. 2010 Feb 12;37(3):370-82
references.pmid: 20159556
references.citation: J Cell Sci. 2004 Sep 15;117(Pt 20):4757-67
references.pmid: 15331637
references.citation: J Mol Biol. 2009 Jun 5;389(2):275-88
references.pmid: 19361519
references.citation: Nature. 2007 Nov 15;450(7168):365-9
references.pmid: 17952054
references.citation: Traffic. 2009 Oct;10(10):1377-89
references.pmid: 19522756
references.citation: J Cell Biol. 2010 Apr 19;189(2):223-32
references.pmid: 20404108
references.citation: Cell. 2006 Nov 17;127(4):817-30
references.pmid: 17110339
references.citation: J Cell Biol. 2008 Sep 22;182(6):1141-51
references.pmid: 18809726
references.citation: FEBS Lett. 2001 Jun 8;498(2-3):197-200
references.pmid: 11412856
references.citation: J Cell Biol. 2000 Oct 30;151(3):551-62
references.pmid: 11062257
references.citation: EMBO J. 2007 Jan 24;26(2):301-12
references.pmid: 17203072
references.citation: J Biol Chem. 2002 Oct 25;277(43):41023-31
references.pmid: 12189143
references.citation: Mol Biol Cell. 2008 Jul;19(7):2718-28
references.pmid: 18434594
references.citation: EMBO J. 2000 Dec 15;19(24):6713-20
references.pmid: 11118206
references.citation: Mol Biol Cell. 2006 Mar;17(3):1286-97
references.pmid: 16394106
references.citation: Science. 1994 Sep 2;265(5177):1405-12
references.pmid: 8073283
references.citation: J Cell Biol. 2007 Jul 30;178(3):363-9
references.pmid: 17646400
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11821-7
references.pmid: 16882731
references.citation: Mol Biol Cell. 2000 Dec;11(12):4403-11
references.pmid: 11102533
references.citation: Cell. 2008 Jun 27;133(7):1202-13
references.pmid: 18585354
references.citation: J Cell Biol. 2002 Jun 10;157(6):1005-15
references.pmid: 12045183
references.citation: EMBO J. 2000 Oct 2;19(19):5105-13
references.pmid: 11013213
references.citation: Biochem Biophys Res Commun. 2001 Sep 28;287(3):688-95
references.pmid: 11563850
references.citation: Dev Cell. 2006 Jul;11(1):47-56
references.pmid: 16824952
references.citation: EMBO J. 2010 Jan 20;29(2):304-14
references.pmid: 19942856
references.citation: J Biol Chem. 1999 Nov 19;274(47):33186-9
references.pmid: 10559187
references.citation: Traffic. 2007 Jan;8(1):47-60
references.pmid: 17132146
references.citation: Cell. 2005 Sep 9;122(5):735-49
references.pmid: 16143105
references.citation: Dev Cell. 2008 Mar;14(3):354-64
references.pmid: 18331716
references.citation: J Cell Biol. 1997 Jun 30;137(7):1495-509
references.pmid: 9199166
references.citation: Cell. 2004 Sep 3;118(5):607-17
references.pmid: 15339665
references.citation: EMBO J. 2000 Sep 15;19(18):4885-94
references.pmid: 10990452
references.citation: J Cell Biol. 2006 Oct 23;175(2):271-81
references.pmid: 17043139
references.citation: Nature. 1997 Oct 16;389(6652):758-62
references.pmid: 9338791
references.citation: Nat Struct Mol Biol. 2006 Mar;13(3):264-71
references.pmid: 16462746
references.citation: EMBO J. 2008 Apr 9;27(7):1145-53
references.pmid: 18309292
references.citation: J Cell Biol. 2003 Dec 8;163(5):973-85
references.pmid: 14662743
references.citation: Biochem J. 2005 Oct 1;391(Pt 1):87-93
references.pmid: 15971998
references.citation: J Biol Chem. 1998 Feb 6;273(6):3253-6
references.pmid: 9452439
references.citation: J Biol Chem. 2000 Oct 13;275(41):31786-91
references.pmid: 10859313
references.citation: Cell. 2006 Mar 24;124(6):1183-95
references.pmid: 16499958
references.citation: J Cell Biol. 2000 Oct 16;151(2):289-96
references.pmid: 11038176
references.citation: Nat Cell Biol. 2005 Sep;7(9):887-93
references.pmid: 16086013
references.citation: J Biol Chem. 2009 Oct 30;284(44):30016-23
references.pmid: 19740738
references.citation: Nature. 2000 Nov 16;408(6810):374-7
references.pmid: 11099046
references.citation: Cell. 2010 Apr 30;141(3):497-508
references.pmid: 20434987
references.citation: J Cell Biol. 2007 Jun 18;177(6):1133-43
references.pmid: 17562788
references.citation: Development. 2008 Jan;135(2):387-99
references.pmid: 18077594
references.citation: J Biol Chem. 2006 Mar 10;281(10):6874-83
references.pmid: 16407276
references.citation: Science. 2007 Nov 9;318(5852):974-7
references.pmid: 17947549
references.citation: Nat Rev Mol Cell Biol. 2001 Feb;2(2):107-17
references.pmid: 11252952
references.citation: Mol Biol Cell. 2002 Sep;13(9):3268-80
references.pmid: 12221131
references.citation: Mol Biol Cell. 2009 Jun;20(12):2900-8
references.pmid: 19403694
references.citation: EMBO J. 1994 Dec 1;13(23):5547-58
references.pmid: 7988552
references.citation: J Cell Biol. 2003 Aug 18;162(4):635-46
references.pmid: 12913108
references.citation: Nat Cell Biol. 2006 Nov;8(11):1263-9
references.pmid: 17041589
references.citation: Nature. 1993 Feb 4;361(6411):464-7
references.pmid: 8429887
references.citation: J Biol Chem. 1998 Sep 18;273(38):24781-5
references.pmid: 9733780
references.citation: J Cell Biol. 1993 Oct;123(1):35-45
references.pmid: 8408203
references.citation: J Cell Biol. 2001 Jul 9;154(1):109-22
references.pmid: 11448994
references.citation: Curr Biol. 1998 Mar 12;8(6):R191
references.pmid: 9512424
references.citation: Mol Biol Cell. 2009 Oct;20(19):4205-15
references.pmid: 19656848
references.citation: J Biol Chem. 2008 Jun 27;283(26):18323-30
references.pmid: 18450757
references.citation: Curr Biol. 2010 Feb 9;20(3):198-208
references.pmid: 20116244
references.citation: Traffic. 2008 Dec;9(12):2032-42
references.pmid: 18801063
references.citation: Mol Biol Cell. 2001 May;12(5):1215-26
references.pmid: 11359917
references.citation: Nature. 1994 Nov 17;372(6503):276-9
references.pmid: 7969474
references.citation: Nat Genet. 2005 Mar;37(3):221-3
references.pmid: 15696165
references.citation: J Biol Chem. 2010 Apr 2;285(14):10627-37
references.pmid: 20154091
references.citation: Proteins. 2008 Apr;71(1):497-502
references.pmid: 18186464
references.citation: EMBO J. 2008 Apr 23;27(8):1183-96
references.pmid: 18354496
references.citation: Nat Struct Biol. 1998 Dec;5(12):1047-52
references.pmid: 9846874
references.citation: Mol Biol Cell. 2006 Jul;17(7):3156-75
references.pmid: 16641372
references.citation: Am J Hum Genet. 2006 Apr;78(4):702-7
references.pmid: 16532399
references.citation: EMBO J. 2006 Apr 5;25(7):1445-55
references.pmid: 16541104