title: A morphometric analysis of neuroanatomic abnormalities in traumatic brain injury.
abstract: Cognitive and structural brain abnormalities are common following traumatic brain injury (TBI). The authors compared cognition and brain structure in 14 TBI survivors and 28 matched healthy comparison subjects. TBI survivors showed reduced cerebral volume, due mainly to white matter changes, and poorer attention, psychomotor speed, and memory. Severity of white matter abnormality correlated with worse performance on several cognitive measures that distinguished between groups. Using voxel-based morphometry, regions of reduced white matter concentration were found throughout the cerebrum along with more localized gray matter reductions. Findings suggest that diffuse rather than focal aspects of TBI contribute most to cognitive outcome.
authors.affiliation: Johns Hopkins Hospital, 600 N. Wolfe St., Meyer 218, Baltimore, MD 21287, USA.
authors.forename: Tracy D
authors.initials: TD
authors.lastname: Vannorsdall
authors.forename: Nicola G
authors.initials: NG
authors.lastname: Cascella
authors.forename: Vani
authors.initials: V
authors.lastname: Rao
authors.forename: Godfrey D
authors.initials: GD
authors.lastname: Pearlson
authors.forename: Barry
authors.initials: B
authors.lastname: Gordon
authors.forename: David J
authors.initials: DJ
authors.lastname: Schretlen
mesh_terms: D000328:Adult; D001288:Attention; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000473:pathology; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D009929:Organ Size; D011597:Psychomotor Performance; D012720:Severity of Illness Index