The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.
Two new metabolites, 3R,5R-Sonnerlactone (1) and 3R,5S-Sonnerlactone (2), were isolated from the mangrove endophytic fungus Zh6-B1 obtained from the South China Sea. Their structures were elucidated by MS and NMR. The absolute configuration of compound 1 was determined by single-crystal X-ray analysis using Cu Kalpha radiation. The absolute configuration of compound 2 was determined by NOESY analysis and comparing circular dichroism spectroscopy with compound 1. The antiproliferative activity of compound 1 and 2 against the multi-drug resistant human oral floor carcinoma cells (KV) was evaluated.
Li
Kai-Kai
KK
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
Lu
Yong-Jun
YJ
Song
Xiao-Hong
XH
She
Zhi-Gang
ZG
Wu
Xi-Wei
XW
An
Lin-Kun
LK
Ye
Chuang-Xing
CX
Lin
Yong-Cheng
YC
D045744:Cell Line, Tumor; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D029561:Lythraceae / Q000737:chemistry* / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D012623:Seawater; D021241:Spectrometry, Mass, Electrospray Ionization