[Genetic and epigenetic changes of FHIT gene in patients with esophageal cancer].
Deletions in the fifth and the eighth exons of FHIT gene were detected using intragenic microsatellites D3s1540 and D3s1234 in the patients with esophageal cancer. Samples were provided from 17 males and 5 females, residents of province Hebei, China. Homozygotic deletions in the fifth or eighth exon were detected in 16 patients. Hypermethylation in FHITgene was found in healthy tissue of only one patient while in 17 patients it appeared in the cancerous tissues. Homozygosis of FHIT gene that was made by deletion or methylation had been found in all the cancerous tissues of the studied patients.
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D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000368:Aged; D002681:China; D004247:DNA / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D044127:Epigenesis, Genetic / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006720:Homozygote; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D008297:Male; D008745:Methylation; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D004247:DNA; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase