title: Biodegradable and pH-sensitive polymersome with tuning permeable membrane for drug delivery carrier.
abstract: Novel biodegradable and pH-sensitive polymersomes prepared from poly(ethylene glycol) and poly(d,l-lactide) grafted poly(beta-amino ester) exhibit pH dependent permeability on hydrophilic solutes of which permeability is determined by the packing state of poly(d,l-lactide) membrane followed by ionization of poly(beta-amino ester) inducing loosely packed membrane formation from well-ordered packing.
authors.affiliation: Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Korea.
authors.forename: Min Sang
authors.initials: MS
authors.lastname: Kim
authors.forename: Doo Sung
authors.initials: DS
authors.lastname: Lee
mesh_terms: D020341:Absorbable Implants; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D008567:Membranes, Artificial; D011108:Polymers