Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.
To better characterize neurophysiologic processes underlying olfactory dysfunction in schizophrenia, nose-referenced 30-channel electroencephalogram was recorded from 32 patients and 35 healthy adults (18 and 18 male) during detection of hydrogen sulfide (constant-flow olfactometer, 200 ms unirhinal exposure). Event-related potentials (ERPs) were transformed to reference-free current source density (CSD) waveforms and analyzed by unrestricted Varimax-PCA. Participants indicated when they perceived a high (10 ppm) or low (50% dilution) odor concentration. Patients and controls did not differ in detection of high (23% misses) and low (43%) intensities and also had similar olfactory ERP waveforms. CSDs showed a greater bilateral frontotemporal N1 sink (305 ms) and mid-parietal P2 source (630 ms) for high than low intensities. N1 sink and P2 source were markedly reduced in patients for high intensity stimuli, providing further neurophysiological evidence of olfactory dysfunction in schizophrenia.
Kayser
Jürgen
J
Division of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA. kayserj@pi.cpmc.columbia.edu
Tenke
Craig E
CE
Malaspina
Dolores
D
Kroppmann
Christopher J
CJ
Schaller
Jennifer D
JD
Deptula
Andrew
A
Gates
Nathan A
NA
Harkavy-Friedman
Jill M
JM
Gil
Roberto
R
Bruder
Gerard E
GE
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016477:Artifacts; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide; D008297:Male; D008875:Middle Aged; D009812:Odorants; D000857:Olfaction Disorders / Q000209:etiology / Q000523:psychology; D025341:Principal Component Analysis; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012903:Smell / Q000502:physiology*; D055815:Young Adult
D006862:Hydrogen Sulfide
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