title: Autoregulation of cardiac l-type calcium channels.
abstract: l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.
authors.affiliation: Department of Physiology, MS508 University of Kentucky College of Medicine, Lexington, KY 40536-0298, USA. jsatin1@uky.edu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Satin
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Schroder
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling; D006706:Homeostasis; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D021381:Protein Transport; D014158:Transcription, Genetic
chemical_list: D020746:Calcium Channels, L-Type; C419385:L-type calcium channel alpha(1C)
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