title: Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates.
abstract: A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3.
authors.affiliation: Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: E
authors.initials: E
authors.lastname: Vijaya Bharathi
authors.forename: M
authors.initials: M
authors.lastname: Janaki Ramaiah
authors.forename: J
authors.initials: J
authors.lastname: Surendranadha Reddy
authors.forename: D
authors.initials: D
authors.lastname: Dastagiri
authors.forename: A
authors.initials: A
authors.lastname: Viswanath
authors.forename: Farheen
authors.initials: F
authors.lastname: Sultana
authors.forename: S N C V L
authors.initials: SN
authors.lastname: Pushpavalli
authors.forename: Manika
authors.initials: M
authors.lastname: Pal-Bhadra
authors.forename: Aarti
authors.initials: A
authors.lastname: Juvekar
authors.forename: Subrata
authors.initials: S
authors.lastname: Sen
authors.forename: Surekha
authors.initials: S
authors.lastname: Zingde
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis; D001569:Benzodiazepines / Q000737:chemistry*; D053148:Caspase 3 / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D006801:Humans; D011758:Pyrroles / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011758:Pyrroles; D016159:Tumor Suppressor Protein p53; D062367:ortho-Aminobenzoates; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines; D053148:Caspase 3; C000219:anthranilamide