Low dose heparin prophylaxis.
Low dose heparin prophylaxis reduces the frequency of postoperative calf vein thrombosis, popliteal and femoral vein thrombosis and nonfatal pulmonary embolism in patients undergoing elective abdominal surgery. In a recent study, it produced an eight-fold reduction in the frequency of major pulmonary emboli detected at autopsy in general surgical patients. Low dose heparin prophylaxis has been less effective in reducing the incidence of venous thromboembolism in patients undergoing hip surgery; in some studies this has been associated with an increased risk of bleeding.
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Circulation. 1973 Apr;47(4):671-6
4572381
Lancet. 1975 Jul 12;2(7924):45-51
49649
Semin Thromb Hemost. 1976 Apr;2(4):203-31
138933
N Engl J Med. 1975 Jan 16;292(3):146-51
127943
Lancet. 1969 Aug 9;2(7615):292-3
4184212
Circulation. 1974 Apr;49(4):603-5
4817700
N Engl J Med. 1975 Mar 27;292(13):665-7
1113762