Cytotoxic cardenolides from the leaves of Calotropis gigantea.
Two 15beta-hydroxycardenolides (1,2) and a 16alpha-hydroxycalactinic acid methyl ester (3) along with eleven known compounds including 16alpha-hydroxycalotropagenin, coroglaucigenin, 16alpha-hydroxycalotropin, calactinic acid, calotoxin, 6'-O-(E-4-hydroxycinnamoyl)desglucouzarin, 12beta-hydroxycoroglaucigenin, frugoside, calotropagenin, 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid and R-(-)-mevalonolactone were isolated from the polar fraction of the CH(2)Cl(2) extract, and n-BuOH extract of the leaves of this plant. The isolated compounds were evaluated for their inhibitory activities against a panel of cell lines.
Seeka
Chonticha
C
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Ramkhamhaeng Road, Bangkapi, Bangkok 10240, Thailand.
Sutthivaiyakit
Somyote
S
D000970:Antineoplastic Agents / Q000737:chemistry*; D031107:Calotropis / Q000737:chemistry*; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
D000970:Antineoplastic Agents; D002298:Cardenolides; D010936:Plant Extracts