title: High-grade histologic lesions in women with low-grade squamous intraepithelial lesion cytology from a region of Thailand with a high incidence of cervical cancer.
abstract: OBJECTIVE
  To evaluate the prevalence of and predictors for underlying significant lesions in women with low-grade squamous intraepithelial lesion (LSIL) smears.
  
  
  METHODS
  Records were retrospectively reviewed for 208 women with LSIL who underwent colposcopy and histological evaluation from October 2004 through April 2009.
  
  
  RESULTS
  Mean age of the patients was 38.5 years. Forty-four (21.2%) women were nulliparous; 20 (9.6%) women were postmenopausal; 29 (13.9%) women tested positive for HIV. Thirty-three (15.9%) women were current users of combined oral contraceptive pills. The pathological results of initial colposcopic evaluations were: 63 (30.3%) with cervical intraepithelial neoplasia (CIN) 2-3; 62 (29.8%) with CIN 1; 4 (1.9%) with cervical cancer; and 79 (38.0%) with no epithelial lesion. Current use of combined oral contraceptive pills, a positive HIV test, and multiparity were significant independent predictors for high-grade disease.
  
  
  CONCLUSIONS
  Approximately one-third of women with LSIL in our population have underlying significant lesions. Current use of combined oral contraceptive pills, a positive HIV test, and multiparity are significant predictors for high-grade lesions.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Rattapon
authors.initials: R
authors.lastname: Kiatiyosnusorn
authors.forename: Prapaporn
authors.initials: P
authors.lastname: Suprasert
authors.forename: Jatupol
authors.initials: J
authors.lastname: Srisomboon
authors.forename: Sitthicha
authors.initials: S
authors.lastname: Siriaree
authors.forename: Surapan
authors.initials: S
authors.lastname: Khunamornpong
authors.forename: Chumnan
authors.initials: C
authors.lastname: Kietpeerakool
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003127:Colposcopy; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology*
chemical_list: D003278:Contraceptives, Oral, Hormonal