title: Larvicidal activity of 94 extracts from ten plant species of northeastern of Brazil against Aedes aegypti L. (Diptera: Culicidae).
abstract: In an effort to find effective and affordable ways to control of Aedes aegypti L. (Diptera: Culicidae), the larvicidal activities of 94 extracts from ten plant species belonging to eight families [Guettarda grazielae and Spermacoce verticillata (Rubiaceae), Coccoloba mollis and Triplaris americana (Polygonaceae), Eschweilera ovata (Lecytidaceae), Merremia aegyptia (Convolvulaceae), Ouratea nitida (Ochnnaceae), Protium heptaphyllum (Burseraceae), Rourea doniana (Connaraceae), and Tovomita brevistaminea (Guttiferae)], widely found in the northeast of Brazil, were initially screened at 250 microg/mL. Nineteen of the 94 extracts from six plant species (C. mollis, G. grazielae, M. aegyptia, R. doniana, S. verticillata, and T. americana) showed significant activity (>75% mortality) against the fourth instar larvae. Some of these extracts showed 100% mosquito larvae mortality, with LD(50) values lower 200 microg/mL. When compared to synthetic insecticide Temephos (LD(50) 8.7 microg/mL), two of them, hexane (LD(50) 12.1 microg/mL) and ethyl acetate (LD(50) 51.6 microg/mL) extracts from stems of R. doniana and G. grazielae, respectively, were the most effective. The isolation and purification of these extracts are in progress and evaluation of these compounds will be needed to identify the active component.
authors.affiliation: Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, 57072-970, Maceió, Alagoas, Brazil.
authors.forename: Patrícia V
authors.initials: PV
authors.lastname: Oliveira
authors.forename: Jesú C
authors.initials: JC
authors.lastname: Ferreira
authors.forename: Fabyanne S
authors.initials: FS
authors.lastname: Moura
authors.forename: Gerson S
authors.initials: GS
authors.lastname: Lima
authors.forename: Fernando M
authors.initials: FM
authors.lastname: de Oliveira
authors.forename: Patrícia Emanuella S
authors.initials: PE
authors.lastname: Oliveira
authors.forename: Lucia M
authors.initials: LM
authors.lastname: Conserva
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Giulietti
authors.forename: Rosangela P Lyra
authors.initials: RP
authors.lastname: Lemos
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D001938:Brazil; D007306:Insecticides / Q000302:isolation & purification / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D016019:Survival Analysis; D000002:Temefos / Q000494:pharmacology
chemical_list: D007306:Insecticides; D010936:Plant Extracts; D000002:Temefos
references.citation: Bioresour Technol. 2006 Sep;97(14):1599-604
references.pmid: 16356712
references.citation: Parasitol Res. 2008 Apr;102(5):867-73
references.pmid: 18163189
references.citation: Indian J Exp Biol. 2004 Dec;42(12):1216-9
references.pmid: 15623234
references.citation: Bioresour Technol. 2007 Sep;98(13):2549-56
references.pmid: 17137781
references.citation: Southeast Asian J Trop Med Public Health. 2005 Nov;36(6):1412-22
references.pmid: 16610643
references.citation: Parasitol Res. 2008 Nov;103(6):1451-3
references.pmid: 18704496
references.citation: Parasitol Res. 2008 Jul;103(2):325-31
references.pmid: 18437424
references.citation: Mem Inst Oswaldo Cruz. 2004 Aug;99(5):541-4
references.pmid: 15543421
references.citation: J Am Mosq Control Assoc. 1991 Jun;7(2):210-37
references.pmid: 1680152
references.citation: Parasitol Res. 2006 Sep;99(4):466-72
references.pmid: 16642386
references.citation: Bioresour Technol. 2009 Dec;100(24):6647-50
references.pmid: 19664915
references.citation: Bioresour Technol. 2006 Dec;97(18):2481-4
references.pmid: 16815011