title: Impact of knee and low back pain on health-related quality of life in Japanese women: the Research on Osteoarthritis Against Disability (ROAD).
abstract: Although knee and low back pain are major public health issues, little information is available on their impact on the quality of life (QOL). We have investigated the impact of knee and low back pain on the QOL in Japanese women by assessing the associations between knee pain and low back pain and various QOL domains using measures such as the Medical Outcomes Study Short Form-8, EuroQOL, and the Western Ontario and McMaster Universities Osteoarthritis Index. From the 3,040 Japanese women participating in the Research on Osteoarthritis Against Disability (ROAD) study, we analyzed data on 1,369 women >40 years old (mean age 68.4 years). We further examined the associations of Kellgren-Lawrence (KL) grade at the knee and lumbar spine and the presence of vertebral fracture (VFx) with the magnitude of QOL loss in women with knee pain and low back pain, respectively. Knee pain and low back pain were found to be significantly associated with lower QOL scores among the women comprising the study cohort. In women with knee pain KL = 4, knee osteoarthritis was strongly associated with the magnitude of QOL loss. For women with low back pain, no significant associations were found between KL grade and magnitude of QOL loss, while there was a moderate association between the latter and VFx.
authors.affiliation: Department of Clinical Motor System Medicine, Faculty of Medicine, 22nd Century Medical and Research Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. murakis-ort@h.u-tokyo.ac.jp
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: En-Yo
authors.forename: Munehito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Akihiko
authors.initials: A
authors.lastname: Saika
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yoshida
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tokimura
authors.forename: Seizo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D017116:Low Back Pain / Q000503:physiopathology / Q000523:psychology*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D018434:Sickness Impact Profile; D055815:Young Adult