Botulinum neurotoxin type-A for primary stabbing headache: an open study.
Primary stabbing headache is an ultra-short headache, associated with primary headaches, more prevalent in women and with a poor response to therapy. The effect of botulinum neurotoxin type-A (BoNTA) on primary stabbing headache was investigated in 24 patients. Three patients showed complete remission. Nineteen patients showed a decrease in their primary stabbing headaches that started in the second week, and that was sustained during approximately 63 days. In two patients BoNTA showed no therapeutic effect. The BoNTA seems to be an excellent therapeutic option for primary stabbing headache.
Piovesan
Elcio Juliato
EJ
Headache Unit, Neurology Division, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil. piovesan@avalon.sul.com.br
Teive
Helio Ghizoni
HG
Kowacs
Pedro André
PA
Silva
Lucas Leite da
LL
Werneck
Lineu Cesar
LC
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D051270:Headache Disorders, Primary / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009498:Neurotoxins / Q000627:therapeutic use*; D010147:Pain Measurement; D012720:Severity of Illness Index; D016896:Treatment Outcome
D009498:Neurotoxins; D019274:Botulinum Toxins, Type A