title: Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins.
abstract: Quinidine was found to catalyze the Michael addition of unprotected 3-substituted oxindoles to nitroolefins in excellent yield and moderate to good diastereoselectivity. Bifunctional quinidine derived thiourea catalyst 10 could catalyze this reaction to afford the major diastereomer in up to 85% ee.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: Ding
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Zi-Qing
authors.initials: ZQ
authors.lastname: Qian
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000475:Alkenes; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D009584:Nitrogen