title: NF-kappaB in the immune response of Drosophila.
abstract: The nuclear factor kappaB (NF-kappaB) pathways play a major role in Drosophila host defense. Two recognition and signaling cascades control this immune response. The Toll pathway is activated by Gram-positive bacteria and by fungi, whereas the immune deficiency (Imd) pathway responds to Gram-negative bacterial infection. The basic mechanisms of recognition of these various types of microbial infections by the adult fly are now globally understood. Even though some elements are missing in the intracellular pathways, numerous proteins and interactions have been identified. In this article, we present a general picture of the immune functions of NF-kappaB in Drosophila with all the partners involved in recognition and in the signaling cascades.
authors.affiliation: Centre National de la Recherche Scientifique, Institute of Molecular and Cellular Biology, 15 rue René Descartes, 67084 Strasbourg, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Hetru
authors.forename: Jules A
authors.initials: JA
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology; D004331:Drosophila melanogaster / Q000276:immunology* / Q000378:metabolism*; D005658:Fungi / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*
chemical_list: D016328:NF-kappa B
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