Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages.
Programmed cell death 4 (Pdcd4), a novel tumor suppressor, has recently emerged as an anti-inflammatory protein. We assessed in the present study the effects of 18 different food factors with anti-inflammatory activity on the lipopolysaccharide-induced down-regulation of pdcd4 mRNA expression in mouse RAW 264.7 macrophages. Genistein, a soy isoflavone, significantly inhibited pdcd4 down-regulation.
Yasuda
Michiko
M
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Irie
Kazuhiro
K
Murakami
Akira
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D051017:Apoptosis Regulatory Proteins / Q000235:genetics; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D015536:Down-Regulation / Q000187:drug effects*; D005502:Food; D019833:Genistein / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics
D000893:Anti-Inflammatory Agents; D051017:Apoptosis Regulatory Proteins; D008070:Lipopolysaccharides; C498443:Pdcd4 protein, mouse; D010936:Plant Extracts; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D019833:Genistein