title: Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI.
abstract: Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic ZnCl(2), Me(3)SiCH(2)MgCl, and LiCl. Tertiary alcohols were obtained in high yields with high chemoselectivities, while minimizing undesired side products produced by reduction and enolization.
authors.affiliation: Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hatano
authors.forename: Orie
authors.initials: O
authors.lastname: Ito
authors.forename: Shinji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara