Is there evidence of separate inflammatory or metabolic forms of preeclampsia?
OBJECTIVE
To examine whether high insulin resistance versus high inflammation identifies subtypes of preeclampsia.


METHODS
A cytokine panel, glucose and insulin were measured in 37 preeclampsia plasma samples. Wilcoxon rank sum assessed median concentration of HOMA(IR) by pro-inflammatory:anti-inflammatory ratio. Regression stratifying by BMI and preterm birth was conducted.


RESULTS
There was no difference in median HOMA(IR) by the pro-inflammatory:anti-inflammatory ratio (p = 0.16). No subsets scatterplot clusters emerged. A positive correlation between HOMAlog and the ratio was significant (p = 0.04).


CONCLUSIONS
No dichotomous subsets of preeclampsia by inflammation versus insulin resistance were detected. Contrary to our hypothesis, insulin resistance was higher as inflammation increased in preeclampsia.
Founds
Sandra A
SA
School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. foundss@pitt.edu
Catov
Janet M
JM
Gallaher
Marcia J
MJ
Harger
Gail F
GF
Markovic
Nina
N
Roberts
James M
JM
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D011225:Pre-Eclampsia / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D011247:Pregnancy
D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin
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