title: Intrahepatic sarcomatoid cholangiocarcinoma.
abstract: Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma. The patient had early onset disease recurrence within 5 weeks of surgery. Here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma. The patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery.
authors.affiliation: Department of Histopathology, Nottingham University Hospitals, Queens Medical Centre Campus, University of Nottingham, NG7 2UH Nottingham, UK.
authors.forename: Shalini
authors.initials: S
authors.lastname: Malhotra
authors.forename: Joanna
authors.initials: J
authors.lastname: Wood
authors.forename: Talal
authors.initials: T
authors.lastname: Mansy
authors.forename: Rajeev
authors.initials: R
authors.lastname: Singh
authors.forename: Abed
authors.initials: A
authors.lastname: Zaitoun
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Madhusudan
references.citation: World J Gastroenterol. 2007 Feb 7;13(5):809-12
references.pmid: 17278210
references.citation: Cancer Chemother Pharmacol. 1989;23 Suppl:S4-8
references.pmid: 2466583
references.citation: Cancer. 1993 Sep 15;72(6):1872-7
references.pmid: 7689920
references.citation: Cancer. 1991 Jul 1;68(1):93-7
references.pmid: 1710948
references.citation: Virchows Arch. 2006 Nov;449(5):585-90
references.pmid: 17033799
references.citation: Ann Oncol. 2006 Jun;17 Suppl 7:vii73-7
references.pmid: 16760299
references.citation: Hum Pathol. 2006 Mar;37(3):283-91
references.pmid: 16613323
references.citation: Tumori. 2004 Sep-Oct;90(5):458-60
references.pmid: 15656328
references.citation: J Gastroenterol. 2003;38(11):1097-101
references.pmid: 14673730
references.citation: Arch Pathol Lab Med. 2000 Jun;124(6):888-90
references.pmid: 10835528