title: Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus.
abstract: Several data link vitamin D to many autoimmune diseases. Association between vitamin D receptor (VDR) gene BsmI polymorphisms and systemic lupus erythematosus has been reported. In this study, we examine whether the VDR gene BsmI polymorphisms are markers for susceptibility to or severity of SLE. This study incorporated 60 patients with SLE living in northeastern Iran. Three genotypes, BB, Bb and bb, were detected based on polymerase chain reaction-restriction fragment length polymorphism (PCR/RFLP). The distribution of VDR genotyping in patients with SLE was 23.3% for BB, 60% for Bb and 16.7% for bb and in the control group was 33.3% for BB, 46.7% for Bb and 20% for bb (P = 0.334). No association of VDR gene BsmI polymorphisms with SLE disease activity index (SLEDAI), SLE damage score and major organ involvement was detected. The result of this study did not show any association between VDR gene BsmI polymorphisms and SLE.
authors.affiliation: Qazvin Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Abbasi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rezaieyazdi
authors.forename: Jalil Tavakol
authors.initials: JT
authors.lastname: Afshari
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Hatef
authors.forename: Maryam
authors.initials: M
authors.lastname: Sahebari
authors.forename: Nayereh
authors.initials: N
authors.lastname: Saadati
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol
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