Effects of magnesium on central arterial compliance in preeclampsia.
OBJECTIVE
The objective of the study was to investigate the effect of MgSO4 infusion on central arterial compliance, using radial artery applanation tonometry in women with preeclampsia.


METHODS
Seventy women with preeclampsia were prospectively recruited. Radial pulse waveforms were obtained and the aortic waveforms constructed. The arterial compliance surrogates, augmentation pressure (AP) and augmentation index (AIx-75), were derived from the aortic waveform and then compared: prior to MgSO4 (t1), 1 hour after MgSO4 bolus (t2), 4 hours after MgSO4 infusion (t3), and 24 hours after MgSO4 cessation (t4). Statistical analysis was performed using differences of least squared means with Tukey Kramer adjustments.


RESULTS
The AP and AIx-75 at t2-t4 were significantly lower compared with t1, with the greatest decrease in arterial stiffness at t3 (P<.05).


CONCLUSIONS
In preeclampsia, MgSO4 improved central arterial compliance. This effect was most exaggerated after 4 hours of infusion and remained 24 hours following MgSO4 completion, suggesting either a sustained arterial compliance effect or resolution of the vasoconstrictive effect of preeclampsia.
Rogers
Dennie T
DT
Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, University of Illinois Hospital at Chicago, Chicago, IL, USA.
Colon
Maria
M
Gambala
Cecilia
C
Wilkins
Isabelle
I
Hibbard
Judith U
JU
D000328:Adult; D001158:Arteries / Q000187:drug effects* / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D003187:Compliance / Q000187:drug effects; D004548:Elasticity; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008365:Manometry; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D017534:Radial Artery / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D055815:Young Adult
D002317:Cardiovascular Agents; D008278:Magnesium Sulfate