A general strategy for construction of a difluoromethyl compound library and its application in synthesis of pseudopeptides bearing a terminal difluoromethyl group.
We describe the development of a novel synthesis strategy that uses common reaction conditions to transform a collection of simple building blocks into complex molecules bearing a terminal difluoromethyl group. The core of this approach is the conscious design and synthesis of new difluorinated building blocks which contain inactive and reactive groups on each side of the CF(2) group. The strategy is illustrated by application to the synthesis of CF(2)H-bearing pseudopeptides via Ugi reaction.
Wu
Jingjing
J
Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Cao
Song
S
Liu
Nianjin
N
Shen
Li
L
Yu
Jinlong
J
Zhang
Jian
J
Li
Hui
H
Qian
Xuhong
X
D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D015195:Drug Design; D005463:Fluoroacetates / Q000737:chemistry; D054879:Halogenation; D010455:Peptides / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry*
D005463:Fluoroacetates; D010455:Peptides; D054852:Small Molecule Libraries