Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract.
In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
Parra
Marley García
MG
Departmento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. marley@ipk.sld.cu
Fidalgo
Lianet Monzote
LM
Martinez
Judith Mendiola
JM
Alvarez
Ana Margarita Montalvo
AM
Iglesias
Olga Valdés
OV
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004447:Echinodermata / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C
D000981:Antiprotozoal Agents