title: Regulation of promyogenic signal transduction by cell-cell contact and adhesion.
abstract: Skeletal myoblast differentiation involves acquisition of the muscle-specific transcriptional program and morphological changes, including fusion into multinucleated myofibers. Differentiation is regulated by extracellular signaling cues, including cell-cell contact and adhesion. Cadherin and Ig adhesion receptors have been implicated in distinct but overlapping stages of myogenesis. N-cadherin signals through the Ig receptor Cdo to activate p38 MAP kinase, while the Ig receptor neogenin signals to activate FAK; both processes promote muscle-specific gene expression and myoblast fusion. M-cadherin activates Rac1 to enhance fusion. Specific Ig receptors (Kirre and Sns) are essential for myoblast fusion in Drosophila, also signaling through Rac, and vertebrate orthologs of Kirre and Sns have partially conserved function. Mice lacking specific cytoplasmic signaling factors activated by multiple receptors (e.g., Rac1) have strong muscle phenotypes in vivo. In contrast, mice lacking individual adhesion receptors that lie upstream of these factors have modest phenotypes. Redundancy among receptors may account for this. Many of the mammalian Ig receptors and cadherins associate with each other, and multivalent interactions within these complexes may require removal of multiple components to reveal dramatic defects in vivo. Nevertheless, it is possible that the murine adhesion receptors rate-limiting in vivo have not yet been identified or fully assessed.
authors.affiliation: Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. Robert.Krauss@mssm.edu
authors.forename: Robert S
authors.initials: RS
authors.lastname: Krauss
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002450:Cell Communication; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D024510:Muscle Development / Q000502:physiology*; D032446:Myoblasts / Q000166:cytology*; D015398:Signal Transduction / Q000502:physiology*
references.citation: Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1082-7
references.pmid: 15647354
references.citation: Dev Cell. 2004 Dec;7(6):843-54
references.pmid: 15572127
references.citation: Dev Cell. 2007 Apr;12(4):571-86
references.pmid: 17419995
references.citation: J Neurosci Res. 2008 Mar;86(4):727-43
references.pmid: 17975827
references.citation: Nat Neurosci. 2008 Jan;11(1):28-35
references.pmid: 18066058
references.citation: J Neurochem. 2008 Aug;106(4):1483-92
references.pmid: 18485097
references.citation: Annu Rev Neurosci. 2003;26:207-38
references.pmid: 12598678
references.citation: J Cell Sci. 2005 Jun 1;118(Pt 11):2355-62
references.pmid: 15923648
references.citation: Methods Mol Biol. 2008;475:75-97
references.pmid: 18979239
references.citation: J Cell Biol. 1997 Jul 28;138(2):331-6
references.pmid: 9230075
references.citation: Dev Biol. 2000 May 1;221(1):112-9
references.pmid: 10772795
references.citation: J Cell Biol. 2008 Mar 10;180(5):1005-19
references.pmid: 18332221
references.citation: Trends Cell Biol. 2009 Jun;19(6):286-94
references.pmid: 19394225
references.citation: J Cell Biol. 2006 Nov 6;175(3):383-8
references.pmid: 17074887
references.citation: J Cell Biochem. 2008 Oct 15;105(3):663-9
references.pmid: 18759329
references.citation: Cell Stem Cell. 2008 Jan 10;2(1):22-31
references.pmid: 18371418
references.citation: Mol Biol Cell. 1998 Jul;9(7):1891-902
references.pmid: 9658178
references.citation: Curr Top Dev Biol. 2009;89:1-32
references.pmid: 19737640
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15446-51
references.pmid: 18820033
references.citation: Mol Cell Biol. 2008 Apr;28(7):2314-23
references.pmid: 18212043
references.citation: Development. 2006 Mar;133(6):1101-12
references.pmid: 16481350
references.citation: J Cell Sci. 2009 Sep 15;122(Pt 18):3282-93
references.pmid: 19706686
references.citation: Development. 2007 Sep;134(17):3145-53
references.pmid: 17670792
references.citation: Differentiation. 2008 Mar;76(3):253-66
references.pmid: 17825087
references.citation: J Cell Biol. 2008 Aug 11;182(3):497-507
references.pmid: 18678706
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4212-7
references.pmid: 20160094
references.citation: Mol Cell Biol. 2002 Jul;22(13):4760-70
references.pmid: 12052883
references.citation: J Cell Biol. 2002 Sep 2;158(5):953-65
references.pmid: 12213839
references.citation: Methods Mol Biol. 2008;475:115-33
references.pmid: 18979241
references.citation: Curr Opin Clin Nutr Metab Care. 2010 May;13(3):243-8
references.pmid: 20098319
references.citation: Mol Cell Biol. 2001 Jul;21(14):4829-36
references.pmid: 11416156
references.citation: Nat Genet. 2007 Jun;39(6):781-6
references.pmid: 17529975
references.citation: Dev Biol. 2010 May 1;341(1):66-83
references.pmid: 19932206
references.citation: Cell. 2003 Sep 19;114(6):751-62
references.pmid: 14505574
references.citation: Hum Mol Genet. 2001 Jan 1;10(1):1-8
references.pmid: 11136707
references.citation: Mol Biol Cell. 2006 Feb;17(2):749-59
references.pmid: 16291866
references.citation: Dev Biol. 2007 Aug 15;308(2):281-93
references.pmid: 17612520
references.citation: Mol Biol Cell. 2009 Dec;20(23):4920-31
references.pmid: 19812254
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8935-40
references.pmid: 19443691
references.citation: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12074-8
references.pmid: 11050238
references.citation: Nature. 1994 Feb 3;367(6462):455-9
references.pmid: 8107803
references.citation: Dev Biol. 1997 Jan 1;181(1):64-78
references.pmid: 9015265
references.citation: Mol Biol Cell. 2007 May;18(5):1734-43
references.pmid: 17332503
references.citation: Exp Cell Res. 2008 Apr 15;314(7):1553-65
references.pmid: 18308302
references.citation: Dev Cell. 2003 May;4(5):673-85
references.pmid: 12737803
references.citation: Exp Cell Res. 2005 Jun 10;306(2):364-72
references.pmid: 15882864
references.citation: Dev Biol. 2007 Jan 1;301(1):70-81
references.pmid: 17150207
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9274-9
references.pmid: 19470472
references.citation: Mol Biol Cell. 2009 Jul;20(14):3422-35
references.pmid: 19458188