Cross-talk between hemidesmosomes and focal contacts: understanding subepidermal blistering diseases.
Because hemidesmosomes and focal contacts (FCs) play major roles in epidermal wound healing and in the pathogenesis of subepidermal blistering diseases, it is of particular importance to understand their cross-talk in the regulation of their assembly and disassembly. In this issue, Ozawa et al. demonstrate that hemidesmosome-enriched protein complex (HPC) and FC dynamics are tightly coregulated in keratinocytes undergoing migration by employing HaCat cells that express fluorescent protein-tagged beta4 integrin and alpha-actinin as markers of HPCs and FCs.
Kitajima
Yasuo
Y
Kizawa Memorial Hospital, 590 Shimokobi, Kobi-cho, Minokamo City, Gifu, Japan. yaskitaj@gifu-u.ac.jp
D000185:Actinin / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001768:Blister / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D022001:Focal Adhesions / Q000502:physiology*; D022002:Hemidesmosomes / Q000502:physiology*; D006801:Humans; D039663:Integrin beta4 / Q000378:metabolism; D015603:Keratinocytes / Q000473:pathology / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
D015415:Biomarkers; D039663:Integrin beta4; D000185:Actinin