title: Paternal recognition of adult offspring mediated by newly generated CNS neurons.
abstract: In mammals, olfaction is often used to distinguish individuals on the basis of their unique odor types (genetically programmed body odors). Parental-offspring recognition behavior is mediated, in part, by learning and processing of different odor types and is crucial for reproductive success. Maternal recognition behavior and associated brain plasticity has been well characterized, but paternal recognition behavior and brain plasticity is poorly understood. We found that paternal-adult offspring recognition behavior in mice was dependent on postnatal offspring interaction and was associated with increased neurogenesis in the paternal olfactory bulb and hippocampus. Newly generated paternal olfactory interneurons were preferentially activated by adult offspring odors. Disrupting prolactin signaling abolished increased paternal neurogenesis and adult offspring recognition. Rescuing this neurogenesis restored recognition behavior. Thus, neurogenesis in the paternal brain may be involved in offspring recognition.
authors.affiliation: Hotchkiss Brain Institute, Department of Cell Biology & Anatomy, University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada.
authors.forename: Gloria K
authors.initials: GK
authors.lastname: Mak
authors.forename: Samuel
authors.initials: S
authors.lastname: Weiss
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000502:physiology*; D049109:Cell Proliferation; D005260:Female; D006624:Hippocampus / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D008297:Male; D008425:Maternal Behavior; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology; D055696:Olfactory Perception / Q000502:physiology*; D010332:Paternal Behavior; D046709:Pattern Recognition, Physiological / Q000502:physiology; D011388:Prolactin / Q000235:genetics / Q000378:metabolism; D021641:Recognition, Psychology / Q000502:physiology*
chemical_list: D011388:Prolactin
references.citation: Curr Biol. 2007 Dec 4;17(23):2061-6
references.pmid: 17997307
references.citation: Trends Ecol Evol. 1996 May;11(5):201-6
references.pmid: 21237809
references.citation: Trends Neurosci. 2006 Nov;29(11):604-9
references.pmid: 16904761
references.citation: J Reprod Dev. 2005 Oct;51(5):547-58
references.pmid: 16284449
references.citation: Science. 2007 Mar 2;315(5816):1243-9
references.pmid: 17303719
references.citation: J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):355-64
references.pmid: 10935023
references.citation: Trends Ecol Evol. 1994 Aug;9(8):294-7
references.pmid: 21236858
references.citation: J Neurosci. 2005 Nov 16;25(46):10729-39
references.pmid: 16291946
references.citation: Nat Neurosci. 2007 Aug;10(8):1003-11
references.pmid: 17603480
references.citation: Nature. 1992 Dec 10;360(6404):581-3
references.pmid: 1461279
references.citation: Physiol Rev. 2005 Jan;85(1):281-317
references.pmid: 15618482
references.citation: J Neurosci. 2007 Feb 21;27(8):1812-23
references.pmid: 17314279
references.citation: Nat Neurosci. 2003 May;6(5):519-25
references.pmid: 12665798
references.citation: Eur J Neurosci. 2005 Dec;22(11):2863-70
references.pmid: 16324121
references.citation: Science. 2003 Jan 3;299(5603):117-20
references.pmid: 12511652
references.citation: Endocrinology. 2000 Oct;141(10):3564-72
references.pmid: 11014209
references.citation: Behav Genet. 1988 Jul;18(4):525-36
references.pmid: 3056389
references.citation: Dev Psychobiol. 1983 Mar;16(2):75-82
references.pmid: 6832487
references.citation: J Neurosci. 2004 Sep 22;24(38):8354-65
references.pmid: 15385618
references.citation: Proc Biol Sci. 2005 Apr 7;272(1564):715-24
references.pmid: 15906464
references.citation: Annu Rev Neurosci. 2005;28:223-50
references.pmid: 16022595
references.citation: Genetica. 1998-1999;104(3):259-63
references.pmid: 10386392
references.citation: Behav Neural Biol. 1984 Jul;41(2):135-51
references.pmid: 6487216
references.citation: Nature. 2003 Sep 11;425(6954):179-81
references.pmid: 12968180
references.citation: Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10500-2
references.pmid: 10973487
references.citation: Science. 1994 Oct 14;266(5183):271-3
references.pmid: 7939661
references.citation: Philos Trans R Soc Lond B Biol Sci. 2006 Dec 29;361(1476):2061-78
references.pmid: 17118924
references.citation: Front Neuroendocrinol. 2001 Apr;22(2):140-5
references.pmid: 11259135
references.citation: Nat Med. 1998 Nov;4(11):1313-7
references.pmid: 9809557
references.citation: J Neurosci. 2002 Apr 1;22(7):2679-89
references.pmid: 11923433
references.citation: Reproduction. 2001 Apr;121(4):529-39
references.pmid: 11277871
references.citation: Behav Brain Res. 2008 Feb 11;187(1):9-16
references.pmid: 17913255
references.citation: Trends Ecol Evol. 1987 Oct;2(10):295-9
references.pmid: 21227869
references.citation: Neurosci Biobehav Rev. 2000 Aug;24(6):669-86
references.pmid: 10940441