Hemostatic alterations in fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver failure. Whatever its cause, the liver failure is accompanied by multiple changes in the hemostatic system. The objective of the current report was to study several homeostasis parameters such as protein C, protein S, factor 7, factor 8 levels, platelet counts, prothrombin time and activated partial thromboplastin time, and plasminogen activator inhibitor in patients with fatty liver. A total of 28 consecutive patients with ultrasound proven NAFLD and 33 healthy volunteers were included in the study. Plasma prothrombin time and activated partial thromboplastin time were within normal ranges in both NAFLD and control groups. Plasma factor 7, factor 8, protein S, and protein C levels were decreased in NAFLD patients but the difference was not statistically significant, whereas plasminogen activator inhibitor 1 levels were significantly increased in patients with NAFLD compared to controls. In conclusion, in all types of liver disease, some alterations in hemostatic parameters are awaited. As fatty liver disease is very common in clinical practice, clinicians should be aware of this kind of alterations.
Kargili
Ayse
A
Department of Internal Medicine, Fatih University Hospital, Ankara, Turkey.
Cipil
Handan
H
Karakurt
Feridun
F
Kasapoglu
Benan
B
Koca
Cemile
C
Aydin
Murat
M
Uysal
Sema
S
Ikizek
Mustafa
M
Uz
Ebru
E
Balcik
Ozlem Sahin
OS
Kosar
Ali
A
D000328:Adult; D001780:Blood Coagulation Tests; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005234:Fatty Liver / Q000097:blood* / Q000000981:diagnostic imaging*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010976:Platelet Count; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D014463:Ultrasonography
D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; D005167:Factor VII; D005169:Factor VIII