Posttranscriptional regulation of microRNA biogenesis in animals.
MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.
Siomi
Haruhiko
H
Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. awa403@sc.itc.keio.ac.jp
Siomi
Mikiko C
MC
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006706:Homeostasis; D035683:MicroRNAs / Q000096:biosynthesis* / Q000737:chemistry; D009690:Nucleic Acid Conformation; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D043244:Ribonuclease III / Q000378:metabolism; D015398:Signal Transduction
D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D043244:Ribonuclease III