Amino acyl conjugates of nitrogen heterocycles as potential pharmacophores.
2-Methyl- and 4-methylpyridine and 2-methylquinoline are converted by benzotriazole-activated (Cbz)-protected amino acids into chiral potential novel pharmacophore aminoacyl conjugates (33-53%).
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
Bajaj
Kiran
K
Charpentier
Mael
M
Zadeh
Ebrahim Ghazvini
EG
D000596:Amino Acids / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009584:Nitrogen; D010847:Picolines / Q000737:chemistry; D011798:Quinaldines / Q000737:chemistry; D014230:Triazoles
D000596:Amino Acids; D006571:Heterocyclic Compounds; D010847:Picolines; D011798:Quinaldines; D014230:Triazoles; C530793:2-picoline; C012771:benzotriazole; C037073:2-methylquinoline; D009584:Nitrogen; C515325:4-methylpyridine