Novoamauromine and ent-Cycloechinulin: two new diketopiperazine derivatives from Aspergillus novofumigatus.
Two new diketopiperazine metabolites, novoamauromine (1) and ent-cycloechinulin (2) have been isolated from Aspergillus novofumigatus CBS117520. The structures of 1 and 2 were established on the basis of spectroscopic and chemical investigation, including a detailed comparison of the spectroscopic and physico-chemical data of amauromine (3) and cycloechinulin (4).
Ishikawa
Kazuki
K
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Hosoe
Tomoo
T
Itabashi
Takeshi
T
Wakana
Daigo
D
Takizawa
Kayoko
K
Yaguchi
Takashi
T
Kawai
Ken-ichi
K
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002853:Chromatography, Liquid; D054659:Diketopiperazines / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D054659:Diketopiperazines; C551760:ent-cycloechinulin; C551759:novoamauromine