title: Plasticity in the human motor system.
abstract: It is well recognized that the number and effectiveness of synapses in the adult brain change in response to learning and that similar processes contribute to the restoration of function after central nervous system damage. It is possible to use non-invasive methods of brain stimulation in humans (transcranial magnetic stimulation or transcranial direct current stimulation) to study and even manipulate these processes. Initial studies are now underway to test whether modification of synaptic plasticity by neurostimulation can improve the recovery of motor function in patients after stroke.
authors.affiliation: Institute of Neurology, University College London, London, UK. j.rothwell @ ion.ucl.ac.uk
authors.forename: John C
authors.initials: JC
authors.lastname: Rothwell
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D001930:Brain Injuries / Q000503:physiopathology / Q000534:rehabilitation; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D009473:Neuronal Plasticity; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation / Q000379:methods
references.citation: Nature. 1990 Sep 6;347(6288):69-72
references.pmid: 1975639
references.citation: Science. 2000 Oct 20;290(5491):533-6
references.pmid: 11039938
references.citation: Cortex. 2009 Oct;45(9):1035-42
references.pmid: 19371866
references.citation: J Rehabil Med. 2003 May;(41 Suppl):7-10
references.pmid: 12817650
references.citation: Electroencephalogr Clin Neurophysiol. 1991 Oct;81(5):366-76
references.pmid: 1718723
references.citation: Clin Neurophysiol. 2001 Nov;112(11):2138-45
references.pmid: 11682353
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1590-5
references.pmid: 19164589
references.citation: Neuron. 2001 Dec 20;32(6):1149-64
references.pmid: 11754844
references.citation: Electroencephalogr Clin Neurophysiol Suppl. 1991;43:227-37
references.pmid: 1773760
references.citation: Neuropsychologia. 2008;46(8):2122-8
references.pmid: 18394661
references.citation: Arch Neurol. 2004 Dec;61(12):1844-8
references.pmid: 15596603
references.citation: Brain Stimul. 2008 Oct;1(4):363-369
references.pmid: 19802336
references.citation: Prog Brain Res. 2001;134:411-25
references.pmid: 11702558
references.citation: Lancet Neurol. 2005 Aug;4(8):454-5
references.pmid: 16033688
references.citation: Neuropsychologia. 2003;41(13):1802-7
references.pmid: 14527543
references.citation: J Clin Neurophysiol. 1991 Jan;8(1):26-37
references.pmid: 2019648
references.citation: Clin Neurophysiol. 2003 Jul;114(7):1272-7
references.pmid: 12842725
references.citation: Neurology. 2001 Nov 27;57(10):1899-901
references.pmid: 11723286