A Systematic Review of Side Effects of Nucleoside and Nucleotide Drugs Used for Treatment of Chronic Hepatitis B.
Although nucleosides and nucleotides have a good safety record for the treatment of hepatitis B, there have been no systematic reviews on this topic. We searched Medline to include studies of the oral antiviral agents for hepatitis B and adverse events, with at least 48 weeks of follow-up from the initiation of treatment with the drug. Important toxicities include nephrotoxicity, myopathy, and resistance. It is often difficult to ascertain whether an adverse effect is from the study drug or the natural progression of the disease. Further safety data are needed for the newer agents and for all agents with regard to patients with decompensated liver disease, renal dysfunction, the elderly, children, and pregnant women.
Khungar
Vandana
V
Han
Steven-Huy
SH
Hepatology. 2009 May;49(5 Suppl):S185-95
19399802
Gastroenterology. 2005 Oct;129(4):1198-209
16230074
Hepatology. 2009 Sep;50(3):727-34
19517525
J Gastroenterol Hepatol. 2008 Sep;23(9):1320-6
18554238
J Viral Hepat. 2008 Feb;15(2):108-14
18184193
Kidney Int. 2004 Sep;66(3):1153-8
15327411
Hepatology. 2009 Jan;49(1):72-9
19065670
Nephrol Dial Transplant. 2004 Feb;19(2):386-90
14736963
Hepatology. 2006 Jul;44(1):108-16
16799983
Am J Gastroenterol. 2008 Nov;103(11):2776-83
18721244
J Hepatol. 2008 May;48(5):728-35
18329126
N Engl J Med. 2007 Dec 20;357(25):2576-88
18094378
N Engl J Med. 1995 Oct 26;333(17):1099-105
7565947
J Gastroenterol Hepatol. 2009 Feb;24(2):255-61
19215336
Hepatology. 2009 Dec;50(6):2001-6
19937695
Gastroenterology. 2006 Jun;130(7):2039-49
16762627
Hepatology. 2006 Nov;44(5):1110-6
17058225
Gastroenterology. 2006 Dec;131(6):1743-51
17087951
Hepatology. 2009 Sep;50(3):661-2
19714720
N Engl J Med. 2006 Mar 9;354(10):1001-10
16525137
J Viral Hepat. 2009 Jul;16(7):471-8
19457140
Gastroenterology. 2007 Nov;133(5):1437-44
17983800
Hepatology. 2008 Jun;47(6):1863-71
18433023
Liver Transpl. 2007 Mar;13(3):349-60
17326221
Eur J Gastroenterol Hepatol. 2006 Dec;18(12):1247-53
17099372
Hepatology. 2008 Sep;48(3):750-8
18752330
Antimicrob Agents Chemother. 2002 Mar;46(3):716-23
11850253
Clin Ther. 2008 Feb;30(2):317-23
18343270
N Engl J Med. 2008 Dec 4;359(23):2442-55
19052126
World J Gastroenterol. 2008 Jun 14;14(22):3549-53
18567085
Hepatology. 2008 Feb;47(2):447-54
18080339
N Engl J Med. 1998 Jul 9;339(2):61-8
9654535
Hepatology. 2006 Jun;43(6):1385-91
16729316
Ann Intern Med. 2007 Dec 4;147(11):745-54
17909201
AIDS. 2008 Sep 12;22(14):1779-87
18753861
J Hepatol. 2006 Jan;44(1):62-7
16274835
Gastroenterology. 2009 Feb;136(2):486-95
19027013
Hepatology. 2006 Aug;44(2):318-25
16871563
Hepatology. 2009 May;49(5):1503-14
19280622
J Hepatol. 2009 Feb;50(2):227-42
19054588
Hepatology. 2008 Jul;48(1):99-108
18537189
Gastroenterology. 2005 Aug;129(2):528-36
16083710