title: Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia.
abstract: Gene amplification is a frequent genetic abnormality in solid tumors, and many oncogenes are activated in this way. In acute myeloid leukemia (AML), a frequent target of gene amplification is chromosome 11, particularly chromosome region 11q23, including the MLL (myeloid/lymphoid leukemia) gene. However, the number of other amplicons from the long arm of chromosome 11 has also been described. Duplication/amplification of chromosome 11 was found by cytogenetic methods in 10 of 119 newly diagnosed patients with AML. The amplification was presented as: amplification including only the 5' segment of the MLL gene (1 patient), trisomy 11 (3 patients), partial trisomy 11q (2 patients), isochromosome 11q (1 patient), and multiple amplification of specific regions (3 patients). In two cases, amplification involved parts of not only long arm but also of short arm of the chromosome 11: 11p15 and 11p11.1 to 11p13.
authors.affiliation: Cytogenetic Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic. iveta.sarova@uhkt.cz
authors.forename: Iveta
authors.initials: I
authors.lastname: Sárová
authors.forename: Jana
authors.initials: J
authors.lastname: Brezinová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zemanová
authors.forename: Silvia
authors.initials: S
authors.lastname: Izáková
authors.forename: Libuse
authors.initials: L
authors.lastname: Lizcová
authors.forename: Eva
authors.initials: E
authors.lastname: Malinová
authors.forename: Adéla
authors.initials: A
authors.lastname: Berková
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Cermák
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Maaloufová
authors.forename: Ludmila
authors.initials: L
authors.lastname: Nováková
authors.forename: Kyra
authors.initials: K
authors.lastname: Michalová
mesh_terms: D000328:Adult; D000368:Aged; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D020440:Gene Duplication; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014314:Trisomy