title: The cyclic dipeptide cyclo(Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae.
abstract: Cyclo(Phe-Pro) is a cyclic dipeptide produced by multiple Vibrio species. In this work, we present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor Vibrio cholerae strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production correlated with reduced transcription of the virulence regulator tcpPH and was alleviated by overexpression of tcpPH.
authors.affiliation: The University of Tennessee Health Sciences Center, Department of Molecular Sciences, 858 Madison Avenue, Memphis, TN 38163, USA. JBina@uthsc.edu
authors.forename: Xiaowen R
authors.initials: XR
authors.lastname: Bina
authors.forename: James E
authors.initials: JE
authors.lastname: Bina
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002772:Cholera Toxin / Q000096:biosynthesis*; D004151:Dipeptides / Q000494:pharmacology*; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D014734:Vibrio cholerae / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D004151:Dipeptides; D010456:Peptides, Cyclic; C118540:cyclo(phenylalanyl-prolyl); D002772:Cholera Toxin
references.citation: Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5403-7
references.pmid: 2052618
references.citation: Proc Natl Acad Sci U S A. 1984 Jun;81(11):3471-5
references.pmid: 6374658
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16403-8
references.pmid: 16254052
references.citation: J Antimicrob Chemother. 2009 Jan;63(1):103-8
references.pmid: 19010827
references.citation: J Bacteriol. 1992 Nov;174(21):6974-80
references.pmid: 1400247
references.citation: Infect Immun. 2008 Aug;76(8):3595-605
references.pmid: 18490456
references.citation: Mol Microbiol. 2000 Oct;38(1):67-84
references.pmid: 11029691
references.citation: J Bacteriol. 2006 Mar;188(6):2214-21
references.pmid: 16513751
references.citation: J Bacteriol. 1988 Jun;170(6):2575-83
references.pmid: 2836362
references.citation: Nature. 2000 Aug 3;406(6795):477-83
references.pmid: 10952301
references.citation: Microbiol Immunol. 1986;30(11):1075-83
references.pmid: 3543624
references.citation: J Bacteriol. 1985 Aug;163(2):580-5
references.pmid: 2991197
references.citation: Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):730-4
references.pmid: 9435261
references.citation: J Bacteriol. 1999 Aug;181(15):4669-72
references.pmid: 10419969
references.citation: J Biol Chem. 2005 Apr 8;280(14):13779-83
references.pmid: 15647287
references.citation: J Bacteriol. 1999 Jul;181(14):4250-6
references.pmid: 10400582
references.citation: Mol Microbiol. 2001 Jul;41(2):393-407
references.pmid: 11489126
references.citation: Future Microbiol. 2007 Jun;2(3):335-44
references.pmid: 17661707
references.citation: BMC Microbiol. 2010 Jan 06;10:3
references.pmid: 20053280
references.citation: J Bacteriol. 1990 Feb;172(2):1077-84
references.pmid: 2137119
references.citation: J Bacteriol. 1995 Jul;177(14):4121-30
references.pmid: 7608087
references.citation: Mol Microbiol. 1999 Feb;31(3):763-71
references.pmid: 10048021