alpha-Glucosidase inhibition properties of cucurbitane-type triterpene glycosides from the fruits of Momordica charantia.
Fourteen cucurbitane-type triterpene glycosides (1-14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A-C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for alpha-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against alpha-glucosidase. Whereas, 2, 3, 6-11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.
Nhiem
Nguyen Xuan
NX
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Kiem
Phan Van
PV
Minh
Chau Van
CV
Ban
Ninh Khac
NK
Cuong
Nguyen Xuan
NX
Tung
Nguyen Huu
NH
Ha
Le Minh
le M
Ha
Do Thi
do T
Tai
Bui Huu
BH
Quang
Tran Hong
TH
Ngoc
Tran Minh
TM
Kwon
Young-In
YI
Jang
Hae-Dong
HD
Kim
Young Ho
YH
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D007422:Intestines / Q000201:enzymology; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000737:chemistry*
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane; D000520:alpha-Glucosidases