New phenanthrenes and stilbenes from Dendrobium loddigesii.
New phenanthrenes, loddigesiinols A (1) and B (7), and stilbenes, loddigesiinols C (8) and D (9), were isolated from 80% ethanol extract of Dendrobium loddigesii ROLFE (Orcharedceae) along with known compounds, including five phenanthrenes, three stilbenes, two lignans, and three sterols. Their structures were determined by spectroscopic studies. These compounds were evaluated for their inhibitory activities against nitric oxide (NO) production and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Phenanthrenes (1-3, 7) and dihydrophenanthrenes (4-6) showed significant inhibitory activity against NO production. In particular, 2 showed stronger inhibitory activity against NO production than 5 and 6. This suggested that this phenanthrene is a stronger inhibitor of NO production than dihydrophenanthrene. The new phenanthrenes, loddigesiinols A (1) and B (7), significantly inhibited NO production with IC(50) values of 2.6 and 10.9 muM, respectively. One new dihydrostilbene, loddigesiinol D (9), showed weak inhibitory activity against NO production with an IC(50) value of 69.7 microM, but the other new dihydrostilbene, loddigesiinol C (8), did not show this activity at 100 microM.
Ito
Masanobu
M
Research Unit of Pharmacognosy, School of Pharmacy, Nihon University, 7-7-1 Narasinodai, Funabashi, Chiba 274-8555, Japan.
Matsuzaki
Keiichi
K
Wang
Jue
J
Daikonya
Akihiro
A
Wang
Nai-Li
NL
Yao
Xin-Sheng
XS
Kitanaka
Susumu
S
D000818:Animals; D002460:Cell Line; D031667:Dendrobium / Q000737:chemistry* / Q000145:classification*; D020128:Inhibitory Concentration 50; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry*
D010616:Phenanthrenes; D013267:Stilbenes; C551754:loddigesiinol A; C551753:loddigesiinol B