Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease.
Several genes have been related to late-onset Alzheimer's disease (LOAD). Phospholipases A2 (PLA2) influence the processing and secretion of the amyloid precursor protein, which gives rise to the beta-amyloid peptide, the major component of the amyloid plaque in AD. Hence, in the present study, polymorphisms of three genes encoding PLA2 enzymes group (cytosolic PLA2: BanI cPLA2 polymorphism; calcium-independent PLA2: AvrII iPLA2 polymorphism; PAFAH: Val279Phe PAFAH polymorphism) were analysed in a case-control sample using 58 patients with LOAD and 107 matched healthy controls. There was a genotypic association between the BanI cPLA2 polymorphism and LOAD (chi2=6.25, 2df, p=0.04), however there was no allelic association. There were no associations between AvrII iPLA2 and Val279Phe PAFAH polymorphisms and LOAD. These data suggest that the BanI cPLA2 polymorphism may play a role in the susceptibility for LOAD in our Brazilian sample.
Cordeiro
Quirino
Q
Institute of Psychiatry, University of São Paulo Medical School, São Paulo, SP, Brazil. qcordeiro@yahoo.com
Noguti
Ricardo
R
Bottino
Cássio M C
CM
Vallada
Homero
H
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000235:genetics*; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D054512:Phospholipases A2, Calcium-Independent / Q000235:genetics*; D054510:Phospholipases A2, Cytosolic / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D054512:Phospholipases A2, Calcium-Independent; D054510:Phospholipases A2, Cytosolic; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase