Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.
BACKGROUND
The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR.


RESULTS
A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements > or =200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0+/-1.4 vs 2.6+/-1.1 micromol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002).


CONCLUSIONS
Serum ADMA levels might play a role in EBPR to exercise.
Kayrak
Mehmet
M
Department of Cardiology, Selcuk University Meram School of Medicine Hospital, Meram, Konya, Turkey.
Bacaksiz
Ahmet
A
Vatankulu
Mehmet Akif
MA
Ayhan
Selim S
SS
Taner
Alparslan
A
Unlü
Ali
A
Yazici
Mehmet
M
Ulgen
Mehmet S
MS
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
C018524:N,N-dimethylarginine; D001120:Arginine