Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression.
Misalignment between the timing of sleep and the circadian pacemaker has been linked to depression symptoms. This study sought to extend earlier findings by comparing sleep and circadian markers in healthy controls and individuals with major depression. Two markers of circadian misalignment correlated with depression severity in the depressed group.
Hasler
Brant P
BP
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Buysse
Daniel J
DJ
Kupfer
David J
DJ
Germain
Anne
A
D000328:Adult; D001831:Body Temperature / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003863:Depression / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012893:Sleep Wake Disorders / Q000209:etiology*; D055815:Young Adult
D008550:Melatonin
Behav Sleep Med. 2008;6(1):55-73
18412037
Emotion. 2009 Oct;9(5):705-16
19803592
Chronobiol Int. 2006;23(1-2):497-509
16687322
J Psychiatry Neurosci. 2000 Nov;25(5):446-58
11109296
J Biol Rhythms. 2009 Dec;24(6):465-76
19926806
Am J Physiol. 1999 Oct;277(4 Pt 2):R1152-63
10516257
Sleep Med Rev. 1997 Nov;1(1):45-56
15310523
J Sleep Res. 2006 Jun;15(2):162-6
16704571
Science. 1979 Nov 9;206(4419):710-3
227056
Curr Biol. 2008 May 6;18(9):678-83
18439826
J Affect Disord. 1991 Oct;23(2):93-8
1753041
Psychiatry Res. 2009 Aug 15;168(3):259-61
19524304
Biol Psychol. 2001 Jul-Aug;57(1-3):67-103
11454435
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7414-9
16648247
Ann Med. 1999 Feb;31(1):12-33
10219711
Psychiatry Res. 2003 Aug 1;119(3):243-50
12914895
Pharmacol Ther. 2007 May;114(2):222-32
17395264
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
6080235
Hum Psychopharmacol. 2008 Oct;23(7):571-85
18680211
Psychiatry Res. 2010 Apr 30;176(2-3):166-73
20132992
Sleep Med. 2010 Feb;11(2):131-6
20044310
Int J Chronobiol. 1976;4(2):97-110
1027738
J Affect Disord. 1999 Jan-Mar;52(1-3):19-29
10357014
J Clin Sleep Med. 2008 Feb 15;4(1):66-9
18350967
J Biol Rhythms. 1999 Jun;14(3):227-36
10452335