Leveraging the membrane - cytoskeleton interface with myosin-1.
Class 1 myosins are small motor proteins with the ability to simultaneously bind to actin filaments and cellular membranes. Given their ability to generate mechanical force, and their high prevalence in many cell types, these molecules are well positioned to carry out several important biological functions at the interface of membrane and the actin cytoskeleton. Indeed, recent studies implicate these motors in endocytosis, exocytosis, release of extracellular vesicles, and the regulation of tension between membrane and the cytoskeleton. Many class 1 myosins also exhibit a load-dependent mechano-chemical cycle that enables them to maintain tension for long periods of time without hydrolyzing ATP. These properties put myosins-1 in a unique position to regulate dynamic membrane-cytoskeleton interactions and respond to physical forces during these events.
McConnell
Russell E
RE
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37205, USA.
Tyska
Matthew J
MJ
D000048:Acanthamoeba / Q000166:cytology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D004023:Dictyostelium / Q000166:cytology; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D008958:Models, Molecular; D024461:Myosin Type I / Q000378:metabolism*
D000255:Adenosine Triphosphate; D024461:Myosin Type I
Nature. 1954 May 22;173(4412):973-6
13165698
Nature. 1995 Dec 14;378(6558):751-3
7501027
J Biol Chem. 1985 Apr 25;260(8):4543-6
3157680
J Biol Chem. 1973 Jul 10;248(13):4682-90
4268863
Science. 1996 Apr 26;272(5261):533-5
8614799
J Biol Chem. 2010 Mar 19;285(12):8675-86
20071333
Annu Rev Physiol. 2004;66:521-45
14977412
J Cell Biol. 1997 Feb 10;136(3):633-47
9024693
J Cell Biol. 1990 Apr;110(4):1137-47
2139032
J Cell Biol. 1993 Aug;122(3):613-21
8335688
Nature. 1980 Jul 31;286(5772):452-6
6995856
J Biol Chem. 1998 Jun 5;273(23):14605-11
9603977
J Cell Biol. 1995 Dec;131(5):1205-21
8522584
J Biol Chem. 1993 Jul 15;268(20):14981-90
8325874
Nature. 1989 Aug 17;340(6234):565-8
2770861
Mol Biol Cell. 2001 Apr;12(4):780-94
11294886
Nat Protoc. 2009;4(3):363-71
19247286
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14332-7
9405612
J Biol Chem. 1998 Jun 5;273(23):14644-8
9603982
Mol Biol Cell. 2006 Nov;17(11):4856-65
16971510
Mol Cell Biol. 2004 Jun;24(12):5447-58
15169906
Genome Biol. 2007;8(9):R196
17877792
J Cell Sci. 2005 Jul 1;118(Pt 13):2891-9
15976448
Mol Biol Cell. 2007 Oct;18(10):4096-105
17699600
Biophys J. 1999 Aug;77(2):1168-76
10423462
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3681-6
16505385
J Mol Biol. 1997 Feb 21;266(2):331-42
9047367
Mol Biol Cell. 1993 Feb;4(2):233-46
8382977
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3693-7
4264772
J Biol Chem. 1992 Feb 15;267(5):3445-54
1737797
FEBS Lett. 2007 Feb 20;581(4):644-50
17257598
J Cell Sci Suppl. 1991;14:11-6
1885650
Curr Opin Cell Biol. 2004 Feb;16(1):61-7
15037306
J Cell Biol. 2000 Sep 4;150(5):1013-26
10973992
Science. 1993 Jul 2;261(5117):50-8
8316857
Nature. 1954 May 22;173(4412):971-3
13165697
Mol Biol Cell. 2005 May;16(5):2443-57
15758024
J Cell Sci. 1996 Mar;109 ( Pt 3):663-73
8907711
J Cell Biol. 2004 Mar 15;164(6):887-97
15024034
J Biol Chem. 1998 Aug 7;273(32):20481-6
9685403
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2703-7
4256552
Nat Genet. 1995 Dec;11(4):369-75
7493015
J Cell Biol. 2003 Apr 28;161(2):237-41
12719468
J Biol Chem. 2008 Nov 14;283(46):32014-23
18772133
Nat Neurosci. 2002 Jan;5(1):41-7
11753415
J Cell Biol. 2004 May 10;165(3):395-405
15138292
Nature. 2005 Aug 25;436(7054):1113-8
16121172
Cell. 2009 Oct 2;139(1):33-44
19804752
FEBS J. 2005 May;272(9):2189-97
15853803
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3118-23
16492791
J Cell Biol. 2007 May 21;177(4):671-81
17502425
J Biol Chem. 1985 Sep 15;260(20):11174-9
3161891
J Biol Chem. 1979 May 10;254(9):3624-30
155069
Structure. 1996 Dec 15;4(12):1475-90
8994973
Biophys J. 2002 Apr;82(4):1869-83
11916846
J Cell Biol. 2000 Jan 10;148(1):127-36
10629223
Cell Regul. 1989 Nov;1(1):55-63
2519618
Biochemistry. 1996 Jan 16;35(2):513-22
8555222
J Cell Biol. 1990 Nov;111(5 Pt 1):1895-904
2229179
Cell Motil Cytoskeleton. 1996;33(1):64-79
8824735
Gastroenterology. 1991 Feb;100(2):395-402
1985037
Nat Cell Biol. 2009 Apr;11(4):443-50
19287378
J Cell Biol. 1990 Aug;111(2):443-51
2143194
Mol Biol Cell. 2010 Mar 15;21(6):970-8
20089841
Cell Motil Cytoskeleton. 2003 Jan;54(1):29-40
12451593
J Biol Chem. 2002 Nov 8;277(45):42763-8
12221091
Neuron. 2005 Aug 18;47(4):541-53
16102537
EMBO J. 2004 Apr 7;23(7):1433-40
15014434
Nat Rev Mol Cell Biol. 2001 May;2(5):392-6
11331914
Nature. 2004 Apr 29;428(6986):950-5
15057245
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6549-53
8022818
J Cell Biol. 2008 Mar 24;180(6):1219-32
18347067
J Cell Sci. 1998 Oct;111 ( Pt 19):2911-22
9730983
Neuron. 1991 Dec;7(6):985-94
1764247
Nature. 1986 Aug 21-27;322(6081):754-6
3748157
Cell. 2002 Feb 8;108(3):371-81
11853671
J Biol Chem. 2004 Mar 5;279(10):8517-25
14724268
J Cell Biol. 1997 Nov 3;139(3):683-93
9348285
J Cell Biol. 1990 Jun;110(6):1955-64
2141028
Curr Opin Cell Biol. 1995 Aug;7(4):587-94
7495580
J Cell Biol. 1996 Apr;133(2):305-23
8609164
J Cell Biol. 1993 Jun;121(6):1357-68
8509455
J Biol Chem. 2005 Dec 16;280(50):41562-7
16254000
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4655-9
3014500
J Neurosci. 2002 Apr 1;22(7):2487-95
11923413
Biochemistry. 1969 Dec;8(12):4964-75
4243803
Nature. 1989 Sep 28;341(6240):328-31
2797149
Dev Cell. 2007 Sep;13(3):391-404
17765682
Dev Cell. 2006 Nov;11(5):629-40
17084356
J Biol Chem. 1999 Oct 29;274(44):31373-81
10531338
J Cell Biol. 1992 Jun;117(6):1241-9
1607386
J Biol Chem. 2007 Oct 5;282(40):29504-13
17702742
Nature. 1999 Apr 8;398(6727):530-3
10206648
Cold Spring Harb Symp Quant Biol. 1995;60:567-71
8824429
J Cell Sci. 1995 Mar;108 ( Pt 3):1093-103
7622596
J Am Soc Nephrol. 2009 Jan;20(1):86-94
19005011
Biochem Soc Trans. 2001 Aug;29(Pt 4):377-84
11497993
Science. 2008 Jul 4;321(5885):133-6
18599791
J Biol Chem. 1979 May 10;254(9):3631-6
429373
J Cell Biol. 1995 Feb;128(4):577-87
7860631
Biochemistry. 2007 Oct 23;46(42):11718-26
17910470
J Cell Biol. 1992 Dec;119(5):1193-203
1447297
Cell Motil Cytoskeleton. 1991;20(4):301-15
1666340
J Neurosci. 2006 Oct 4;26(40):10243-52
17021180
Trends Cell Biol. 2009 Jun;19(6):245-52
19406643
J Biol Chem. 2010 Feb 19;285(8):5738-47
20018884
J Muscle Res Cell Motil. 2004;25(6):483-7
16106534
Neuron. 1994 Jan;12(1):1-9
8292354
EMBO J. 2002 Jun 3;21(11):2517-25
12032065
Science. 2006 Oct 6;314(5796):136-9
17023661
J Muscle Res Cell Motil. 2007;28(6):285-91
17994197
J Cell Biol. 2006 Jun 5;173(5):665-71
16754954
J Cell Sci. 2003 Oct 1;116(Pt 19):3985-99
12953059
FEBS Lett. 2010 Feb 5;584(3):493-9
19968988
J Biol Chem. 1991 Jan 15;266(2):1312-9
1824700
J Cell Biol. 2009 Jun 29;185(7):1285-98
19564407
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11972-7
19574460
C R Biol. 2005 Feb;328(2):155-62
15771001
Neuron. 2004 Oct 14;44(2):309-20
15473969
BMC Biochem. 2002 Nov 26;3:31
12453307