Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as a type I diabetes models.
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic beta-cells. Several animal models have been used to study T1DM. Among them, mini-pig seems to be a useful model of diabetes because of its similarities in anatomy and physiology to humans. The purpose of this study is to analyze differentially expressed pancreatic proteins in streptozotocin (STZ)-induced mini-pig T1DM model. The pancreas proteins from mini-pigs treated with STZ were separated by 2-dimensional gel electrophoresis and eleven protein spots were found to be altered significantly compared with control mini-pigs. The data in this study from proteomic analysis provide a valuable resource for the further understanding of T1DM pathomechanism.
Lee
Phil Young
PY
Medical Proteomics Research Center, KRIBB, Daejeon, Korea.
Park
Sung Goo
SG
Kim
Eun Young
EY
Lee
Myung Sup
MS
Chung
Sang J
SJ
Lee
Sang Chul
SC
Yu
Dae Yeul
DY
Bae
Kwang-Hee
KH
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D013058:Mass Spectrometry; D010179:Pancreas / Q000378:metabolism*; D040901:Proteomics / Q000379:methods; D013311:Streptozocin; D013552:Swine; D013556:Swine, Miniature
D013311:Streptozocin