Association of interleukin-1 receptor antagonist gene polymorphisms with generalized aggressive periodontitis in an Iranian population.
BACKGROUND
Periodontitis is a multifactorial disease that occurs in the presence of bacteria, environmental factors, and genetic predispositions. It is suggested that polymorphisms in the interleukin-1 (IL1) receptor antagonist gene have an important role in the susceptibility of the host to periodontitis. This study investigates the association of a variable number of tandem repeat polymorphism in the IL1RN gene with generalized aggressive periodontitis (GAgP).


METHODS
Sixty-six subjects with GAgP and 56 periodontally healthy subjects took part in the study. All subjects were of Iranian Khorasanian (north-east province of Iran) descent. Subjects were identified through clinical examinations and radiographs at the Mashad Dental School and Dental Research Center. DNA was extracted from peripheral blood cells, and different genotypes were detected using polymerase chain reaction amplification and fragment-size analysis. Data were analyzed using the chi(2) test.


RESULTS
The frequencies of the IL1RN genotype A1A2 (chi(2) test; P = 0.001) and allele A2 (chi(2) test; P = 0.006) were found to be significantly increased in patients with GAgP compared to normal subjects.


CONCLUSIONS
These findings suggest that the polymorphic IL1RN gene is a risk determinant for generalized aggressive periodontitis in the Iranian Khorasanian population.
Baradaran-Rahimi
Hesam
H
Department of Periodontology, School of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Radvar
Mehrdad
M
Arab
Hamid R
HR
Tavakol-Afshari
Jalil
J
Ebadian
Ahmad R
AR
D000328:Adult; D010520:Aggressive Periodontitis / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007492:Iran; D008297:Male; D018598:Minisatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D055815:Young Adult
D005819:Genetic Markers; D053590:Interleukin 1 Receptor Antagonist Protein