title: Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy.
abstract: To evaluate cortical architecture in mesial temporal lobe epilepsy (MTLE) with respect to electrophysiology, we analyze both magnetic resonance imaging (MRI) and magnetoencephalography (MEG) in 19 patients with left MTLE. We divide the patients into two groups: 9 patients (Group A) have vertically oriented antero-medial equivalent current dipoles (ECDs). 10 patients (Group B) have ECDs that are diversely oriented and widely distributed. Group analysis of MRI data shows widespread cortical thinning in Group B compared with Group A, in the left hemisphere involving the cingulate, supramarginal, occipitotemporal and parahippocampal gyri, precuneus and parietal lobule, and in the right hemisphere involving the fronto-medial, -central and -basal gyri and the precuneus. These results suggest that regardless of the presence of hippocampal sclerosis, in a subgroup of patients with MTLE a large cortical network is affected. This finding may, in part, explain the unfavorable outcome in some MTLE patients after epilepsy surgery.
authors.affiliation: Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
authors.forename: Claus
authors.initials: C
authors.lastname: Reinsberger
authors.forename: Naoaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Cole
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Dworetzky
authors.forename: Edward B
authors.initials: EB
authors.lastname: Bromfield
authors.forename: Lorie
authors.initials: L
authors.lastname: Hamiwka
authors.forename: Blaise F
authors.initials: BF
authors.lastname: Bourgeois
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Golby
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Madsen
authors.forename: Steven M
authors.initials: SM
authors.lastname: Stufflebeam
mesh_terms: D000328:Adult; D001683:Biological Clocks; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*; D055815:Young Adult
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