[Mechanism of development of epidemic process of group A streptococcal infection in children collectives].
OBJECTIVE
To study the characteristics of group A streptococcal infection epidemic process in children aged 12 - 14 years arrived to summer camp "Orlenok" (Tuapse) from different regions of Russia.


METHODS
Epidemiological (retrospective analysis of incidence of acute respiratory infections, tonsillitis, and scarlet fever), microbiological (isolation and identification of group A streptococci [GAS]), and molecular biological (pulse-electrophoresis, analysis of spe and emm genes) methods were used for the study. Objects of the study were GAS strains isolated from patients and carriers.


RESULTS
Performed genotyping showed that cases of GAS infection in newly formed children collectives were caused by 2 - 3 epidemically important clones, which were genotypically heterogenous.


CONCLUSIONS
Performed molecular biologic studies demonstrated polyclonal structure of GAS that determines the features of development of epidemic process.
Briko
N I
NI
Riapis
L A
LA
Dmitrieva
N F
NF
Eshchina
A S
AS
Kirillov
M Iu
MIu
Torchinskiĭ
N V
NV
Gerasimov
A N
AN
Zhukov
V V
VV
D000293:Adolescent; D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D002353:Carrier State; D002648:Child; D004196:Disease Outbreaks; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D015994:Incidence; D007899:Leisure Activities; D017720:Molecular Epidemiology; D012426:Russia / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology*; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D005098:Exotoxins; C027951:erythrogenic toxin; C014689:streptococcal M protein