title: [Foetal akinesia-hypokinesia deformation sequence].
abstract: Foetal akinesia-hypokinesia deformation sequence (FADS) involves arthrogryposis, facial deformations, pulmonary hypoplasia, intrauterine growth retardation, polyhydramnios and short umbilical cord. FADS is caused by lack of foetal movements, most often due to neuromuscular diseases. FADS is associated with a high mortality rate, and the infants usually die due to pulmonary hypoplasia. Antenatal diagnosis by ultrasound is possible when the condition is pronounced, or by genetic investigation, on suspicion of a specific underlying disease with known genetics.
authors.affiliation: Aalborg Sygehus, Paediatrisk Afdeling, Denmark. bayabayabayat@hotmail.com
authors.forename: Allan
authors.initials: A
authors.lastname: Bayat
authors.forename: Astrid
authors.initials: A
authors.lastname: Petersen
authors.forename: Margrethe
authors.initials: M
authors.lastname: Møller
authors.forename: Graziella
authors.initials: G
authors.lastname: Andersen
authors.forename: Finn
authors.initials: F
authors.lastname: Ebbesen
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology / Q000235:genetics / Q000473:pathology; D001176:Arthrogryposis / Q000235:genetics / Q000473:pathology; D005315:Fetal Diseases / Q000209:etiology / Q000235:genetics / Q000473:pathology; D005317:Fetal Growth Retardation / Q000235:genetics / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D009468:Neuromuscular Diseases / Q000235:genetics / Q000473:pathology; D011379:Prognosis