[Protective effect of marine collagen peptide on liver and renal injuries in diabetic rats induced by alloxan].
OBJECTIVE
To investigate the protective effect of Marine Collagen Peptides (MCPs) on liver and renal injury in diabetic rat induced by alloxan.


METHODS
Twenty-four diabetic rats were randomly divided into four groups and MCPs (0, 0.3575 g/kg bw, 1.0833 g/kg bw and 3.25 g/kg bw respectively) were given intragastrically. Liver function (ALT) and renal function (BUN) were measured before and 20 days after intervention with Marine Collagen Peptides. The SOD activity and MDA content of liver were measured 20 days after the intervention.


RESULTS
There were no significant changes of ALT before and after intervention. Treatment of diabetic rats with 1.0833 g/kg bw and 3.25 g/kg bw MCPs resulted in a significant reduction in BUN. The activity of SOD was enhanced and the MDA content was decreased concomitantly in the liver of diabetic rats treated with high MCPs (3.25 g/kg bw).


CONCLUSIONS
Marine Collagen Peptides might play a protective role on liver and renal function of alloxan-induced diabetic rats by improving antioxidant activity of the body.
Zhao
Ming
M
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Zhang
Zhaofeng
Z
Liang
Jiang
J
Li
Yong
Y
D000496:Alloxan; D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D008107:Liver Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D010455:Peptides / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D010455:Peptides; D020011:Protective Agents; D000496:Alloxan; D003094:Collagen