p63 in skin development and ectodermal dysplasias.
The transcription factor p63 is critically important for skin development and maintenance. Processes that require p63 include epidermal lineage commitment, epidermal differentiation, cell adhesion, and basement membrane formation. Not surprisingly, alterations in the p63 pathway underlie a subset of ectodermal dysplasias, developmental syndromes in which the skin and skin appendages do not develop normally. This review summarizes the current understanding of the role of p63 in normal development and ectodermal dysplasias.
Koster
Maranke I
MI
Department of Dermatology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA. Maranke.Koster@ucdenver.edu
D004475:Ectoderm / Q000002:abnormalities* / Q000254:growth & development*; D004476:Ectodermal Dysplasia / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*
C081876:CKAP4 protein, human; D008565:Membrane Proteins
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