title: Serum amino-terminal pro-brain natriuretic peptide in hematological patients with neutropenic fever: a prospective comparison with C-reactive protein.
abstract: Serum amino-terminal pro-brain natriuretic peptide (NT-proBNP) is considered as a prognostic marker in patients with severe sepsis or septic shock, but no data are available on NT-proBNP kinetics in hematological patients with neutropenic fever. Altogether 70 hematological patients with neutropenic fever were included in this prospective study. NT-proBNP and C-reactive protein (CRP) were determined at the beginning of the neutropenic fever (d0) and then daily up to 3-4 days. The median NT-proBNP (interquartile range) increased from 127 (57-393) ng/L on d0 to 542 (194-1385) ng/L on d4. The increment of CRP was from 35 (17-61) mg/L on d0 to 109 (56-109) mg/L on d2. Neither serial NT-proBNP nor CRP predicted development of severe sepsis, but NT-proBNP was significantly higher in patients with previous cardiovascular disease than in those without. NT-proBNP seemed to reflect cardiac distress, but it did not help to predict the development of severe sepsis in this patient group.
authors.affiliation: Department of Medicine, Kuopio University Hospital, Kuopio, Finland. sari.hamalainen@kuh.fi
authors.forename: Sari
authors.initials: S
authors.lastname: Hämäläinen
authors.forename: Auni
authors.initials: A
authors.lastname: Juutilainen
authors.forename: Taru
authors.initials: T
authors.lastname: Kuittinen
authors.forename: Tapio
authors.initials: T
authors.lastname: Nousiainen
authors.forename: Irma
authors.initials: I
authors.lastname: Matinlauri
authors.forename: Kari
authors.initials: K
authors.lastname: Pulkki
authors.forename: Irma
authors.initials: I
authors.lastname: Koivula
authors.forename: Esa
authors.initials: E
authors.lastname: Jantunen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000150:complications; D005260:Female; D005334:Fever / Q000097:blood* / Q000150:complications; D006402:Hematologic Diseases / Q000097:blood* / Q000150:complications / Q000601:surgery; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009503:Neutropenia / Q000097:blood* / Q000150:complications; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000175:diagnosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein