title: Autophagy and its physiological relevance in arthropods: current knowledge and perspectives.
abstract: Autophagic process is one of the best examples of a conserved mechanism of survival in eukaryotes. At the molecular level there are impressive similarities between unicellular and multicellular organisms, but there is increasing evidence that the same process may be used for different ends, i.e., survival or death, at least at cellular levels. Arthropods encompass a wide variety of invertebrates such as insects, crustaceans and spiders, and thus represent the taxon in which most of the investigations on autophagy in non-mammalian models are performed. The present review is focused on the genetic basis and the physiological meaning of the autophagic process on key models of arthropods. The involvement of autophagy in programmed cell death, especially during oogenesis and development, is also discussed.
authors.affiliation: Department of Biology, University of Modena and Reggio Emilia, Modena, Italy. davide.malagoli@unimore.it
authors.forename: Davide
authors.initials: D
authors.lastname: Malagoli
authors.forename: Fabio C
authors.initials: FC
authors.lastname: Abdalla
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.forename: Qili
authors.initials: Q
authors.lastname: Feng
authors.forename: Kozo
authors.initials: K
authors.lastname: Fujisaki
authors.forename: Ales
authors.initials: A
authors.lastname: Gregorc
authors.forename: Tomohide
authors.initials: T
authors.lastname: Matsuo
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Nezis
authors.forename: Issidora S
authors.initials: IS
authors.lastname: Papassideri
authors.forename: Miklós
authors.initials: M
authors.lastname: Sass
authors.forename: Elaine C M
authors.initials: EC
authors.lastname: Silva-Zacarin
authors.forename: Gianluca
authors.initials: G
authors.lastname: Tettamanti
authors.forename: Rika
authors.initials: R
authors.lastname: Umemiya-Shirafuji
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001181:Arthropods / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D001343:Autophagy / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006728:Hormones / Q000494:pharmacology; D008018:Life Cycle Stages / Q000187:drug effects; D009866:Oogenesis / Q000187:drug effects
chemical_list: D006728:Hormones