'In vivo' optical approaches to angiogenesis imaging.
In recent years, molecular imaging gained significant importance in biomedical research. Optical imaging developed into a modality which enables the visualization and quantification of all kinds of cellular processes and cancerous cell growth in small animals. Novel gene reporter mice and cell lines and the development of targeted and cleavable fluorescent "smart" probes form a powerful imaging toolbox. The development of systems collecting tomographic bioluminescence and fluorescence data enabled even more spatial accuracy and more quantitative measurements. Here we describe various bioluminescent and fluorescent gene reporter models and probes that can be used to specifically image and quantify neovascularization or the angiogenic process itself.
Snoeks
T J A
TJ
Department of Endocrinology, Leiden University Medical Center, Building 1, C4-R86, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
Löwik
C W G M
CW
Kaijzel
E L
EL
D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes / Q000378:metabolism; D017930:Genes, Reporter; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D055620:Optical Phenomena
D005456:Fluorescent Dyes
Am J Pathol. 2003 Oct;163(4):1677-86
14507674
Cancer Metastasis Rev. 2007 Jun;26(2):281-90
17603752
Nephrology (Carlton). 2009 Feb;14(1):86-93
19143941
Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16745-9
15556995
Bioconjug Chem. 2002 Jan-Feb;13(1):128-35
11792188
Nano Lett. 2006 Jan;6(1):1-6
16402777
Nat Rev Cancer. 2005 Oct;5(10):796-806
16195751
Eur J Nucl Med Mol Imaging. 2006 Jul;33(7):841-8
16699765
Physiol Genomics. 2006 Jan 12;24(2):173-80
16410544
Opt Express. 2008 Feb 4;16(3):1481-6
18542223
Mol Ther. 2005 Mar;11(3):435-43
15727940
Anal Chem. 2002 Sep 1;74(17):4378-85
12236345
J Biomed Opt. 2008 Sep-Oct;13(5):054035
19021415
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2616-21
11226288
Am J Pathol. 2002 Apr;160(4):1393-403
11943724
Cancer Res. 2004 Nov 1;64(21):8009-14
15520209
Science. 2009 May 8;324(5928):804-7
19423828
Cell. 1990 Feb 23;60(4):585-95
1689217
PLoS One. 2007 Oct 03;2(10):e974
17912353
Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13291-5
15331785
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14004-9
19666490
Blood. 2004 Jan 15;103(2):617-26
14512298
Genesis. 2000 Oct;28(2):75-81
11064424
Int J Cancer. 2002 Dec 10;102(5):469-75
12432548
Neuron. 1994 Jan;12(1):11-24
8292356
Am J Pathol. 1997 May;150(5):1673-85
9137092
Bioconjug Chem. 2008 May;19(5):1049-54
18407683
Biomaterials. 2006 Nov;27(31):5452-8
16843524
Gene Ther. 2000 Mar;7(6):493-8
10757022
Nano Lett. 2006 Apr;6(4):669-76
16608262
Anticancer Res. 2006 Sep-Oct;26(5A):3237-42
17094435
Mol Cancer Ther. 2007 Nov;6(11):2900-8
17989317
Angiogenesis. 2009;12(1):17-24
19067197
Bioconjug Chem. 2005 Nov-Dec;16(6):1433-41
16287239
Methods Mol Biol. 2008;494:275-94
18726580
Mol Imaging. 2003 Jan;2(1):50-64
12926237
Radiology. 2001 Nov;221(2):523-9
11687699
J Clin Invest. 2002 Mar;109(6):777-85
11901186
Am J Pathol. 2000 Jul;157(1):103-10
10880381
J Clin Invest. 2001 Feb;107(4):409-17
11181640
Nat Med. 2001 Jun;7(6):743-8
11385514
Science. 2006 Apr 14;312(5771):217-24
16614209
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1702-7
14755051
J Photochem Photobiol B. 2010 Jan 21;98(1):77-94
20031443
Cell. 1993 Mar 26;72(6):835-46
7681362
Mol Imaging Biol. 2006 Jul-Aug;8(4):226-36
16791749
J Surg Res. 2007 Jun 15;140(2):165-70
17418866
Neoplasia. 2001 Nov-Dec;3(6):527-34
11774035
Anticancer Res. 2007 Mar-Apr;27(2):713-8
17465193
Dev Biol. 1999 Jan 15;205(2):309-21
9917366
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):377-82
11752410
J Histochem Cytochem. 2002 Jun;50(6):767-77
12019293
ILAR J. 2008;49(1):78-88
18172335
Nat Methods. 2007 Sep;4(9):741-6
17721542
Methods Mol Biol. 2009;574:15-23
19685296
PLoS One. 2009;4(4):e5077
19347037
Annu Rev Biomed Eng. 2002;4:235-60
12117758
Pharmacol Rev. 2000 Jun;52(2):237-68
10835101
Radiology. 2003 Jan;226(1):214-20
12511693
Science. 2002 Apr 5;296(5565):151-5
11884718
Clin Exp Metastasis. 2006;23(7-8):315-22
17136576
J Nucl Med. 2009 Dec;50(12):2058-63
19910439
Cancer Res. 2001 Mar 1;61(5):1781-5
11280722
Biochem Biophys Res Commun. 2008 Apr 4;368(2):364-7
18237547
Science. 1994 Apr 22;264(5158):569-71
7512751
Mol Imaging Biol. 2010 Oct;12(5):488-99
19960268
Mol Cell. 2007 Apr 13;26(1):63-74
17434127
J Biomed Opt. 2005 Jul-Aug;10(4):41207
16178631
Nat Biotechnol. 2004 Dec;22(12):1567-72
15558047
Circ Res. 1996 Aug;79(2):277-85
8756005
Biomaterials. 2008 Apr;29(11):1720-9
18155761
J Biomed Opt. 2007 Mar-Apr;12(2):024017
17477732
Oncogene. 1994 Dec;9(12):3417-26
7970700
Mol Imaging. 2005 Jul-Sep;4(3):182-93
16194450
Nat Med. 2007 Apr;13(4):504-9
17351626
Mol Cancer. 2007 Jun 12;6:41
17565663
Int J Cancer. 1999 Dec 10;83(6):798-802
10597197
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14259-62
14614130
J Invest Dermatol. 2000 May;114(5):909-16
10771470
Gastroenterology. 2002 Feb;122(2):406-14
11832455
Gene. 1996;173(1 Spec No):5-11
8707056
Ann N Y Acad Sci. 2005 May;1041:398-414
15956738
Oncol Res. 1997;9(6-7):327-32
9406238
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14595-600
11734653
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9958-61
12904579
FEBS Lett. 1997 May 5;407(3):313-9
9175875
Radiology. 2007 Mar;242(3):751-8
17325064
Opt Express. 2009 Nov 23;17(24):21925-34
19997437
Cancer Res. 2005 Jul 15;65(14):6330-6
16024635
Nat Biotechnol. 1999 Apr;17(4):375-8
10207887
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12634-9
15304647
J Nucl Med. 1999 Jun;40(6):1061-71
10452325
Cancer Res. 2005 Jun 15;65(12):5352-7
15958583
Cancer Res. 2005 Mar 15;65(6):2337-43
15781648
Nat Med. 2003 Jan;9(1):123-8
12514725