title: Cyclic spermidine alkaloids and flavone glycosides from Meehania fargesii.
abstract: The dried whole plant of Meehania fargesii (H. LéV.) C. Y. WU is utilized as an antipyretic and antidote for poison in China. Water soluble fractions, obtained from an 80% acetone extract of the whole plant, showed hyaluronidase inhibitory activity. From these fractions, hyaluronidase inhibitors were isolated along with two new spermidine alkaloids (meefarnines A and B), four new flavone glycosides (fargenins A-D), and 10 known compounds. The structure of each was elucidated by spectroscopic methods.
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. murata-t@tohoku-pharm.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018514:Plant Structures / Q000737:chemistry*; D012995:Solubility; D013095:Spermidine / Q000737:chemistry* / Q000494:pharmacology; D014867:Water / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D004791:Enzyme Inhibitors; D047309:Flavones; D006027:Glycosides; D014867:Water; D006821:Hyaluronoglucosaminidase; D013095:Spermidine