title: [Late gadolinium enhancement in the diagnostics of ischemic heart disease: technical principles, contrast optimization and clinical application].
abstract: BACKGROUND
  The purpose of the study was to explore a "dark blood" technique and to compare it with a standard inversion recovery gradient echo (IR GRE) sequence in the visualization of myocardial infarction.
  
  
  METHODS
  A total of 9 patients were examined with standard IR GRE and a "dark blood" sequence 15 mins after contrast medium application (0.2 mmol/kg body weight gadobenate dimeglumine). Contrast-to-noise ratios (CNR) were calculated for each sequence.
  
  
  RESULTS
  The CNR(inf-lvc) was significantly higher in the "dark blood" technique compared to the IR GRE sequence, while the CNR(inf-myo) was significantly lower.
  
  
  CONCLUSIONS
  Small subendocardial infarctions may be easier to detect with the "dark blood" technique. However, the standard IR GRE sequence is superior in the demarcation of infarctions in relation to the myocardium and cannot be replaced by the "dark blood" technique.
authors.affiliation: Institut für Klinische Radiologie, Klinikum der Ludwig-Maximilians-Universität München, Campus Grosshadern, Marchioninistr. 15, 81377, München, Deutschland. Kerstin.Bauner@med.uni-muenchen.de
authors.forename: K U
authors.initials: KU
authors.lastname: Bauner
authors.forename: A
authors.initials: A
authors.lastname: Biffar
authors.forename: M
authors.initials: M
authors.lastname: Greif
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Picciolo
authors.forename: D
authors.initials: D
authors.lastname: Theisen
authors.forename: T A
authors.initials: TA
authors.lastname: Sandner
authors.forename: M
authors.initials: M
authors.lastname: Notohamiprodjo
authors.forename: M F
authors.initials: MF
authors.lastname: Reiser
authors.forename: B J
authors.initials: BJ
authors.lastname: Wintersperger
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
references.citation: Lancet. 2003 Feb 1;361(9355):374-9
references.pmid: 12573373
references.citation: AJR Am J Roentgenol. 2006 Mar;186(3):627-33
references.pmid: 16498088
references.citation: Circulation. 2006 Jul 4;114(1):32-9
references.pmid: 16801462
references.citation: Radiology. 2005 Dec;237(3):854-60
references.pmid: 16304107
references.citation: N Engl J Med. 2000 Nov 16;343(20):1445-53
references.pmid: 11078769
references.citation: Circulation. 2006 Jun 13;113(23):2733-43
references.pmid: 16754804
references.citation: Circulation. 2002 Jan 15;105(2):224-9
references.pmid: 11790705
references.citation: Invest Radiol. 2009 Feb;44(2):95-104
references.pmid: 19077911
references.citation: Magn Reson Med. 2007 Jul;58(1):34-40
references.pmid: 17659622
references.citation: Radiology. 2005 Sep;236(3):1041-6
references.pmid: 16055693
references.citation: Radiology. 2001 Jan;218(1):215-23
references.pmid: 11152805
references.citation: Circulation. 2007 Apr 17;115(15):2006-14
references.pmid: 17389270
references.citation: Circulation. 2009 Nov 24;120(21):2069-76
references.pmid: 19901193
references.citation: Invest Radiol. 2006 Feb;41(2):148-53
references.pmid: 16428986
references.citation: Magn Reson Med. 2002 Feb;47(2):372-83
references.pmid: 11810682
references.citation: Eur Heart J. 2004 Nov;25(21):1940-65
references.pmid: 15522474
references.citation: Circulation. 1998 Mar 3;97(8):765-72
references.pmid: 9498540
references.citation: Circulation. 2003 Oct 21;108(16):1945-53
references.pmid: 14557364
references.citation: J Cardiovasc Magn Reson. 2007;9(2):93-491
references.pmid: 17192234
references.citation: Invest Radiol. 2007 Jun;42(6):361-71
references.pmid: 17507806
references.citation: Circulation. 1999 Nov 9;100(19):1992-2002
references.pmid: 10556226
references.citation: Circulation. 2006 Feb 21;113(7):969-76
references.pmid: 16476852
references.citation: Radiology. 2004 Dec;233(3):921-6
references.pmid: 15516607
references.citation: JACC Cardiovasc Imaging. 2009 Jan;2(1):34-44
references.pmid: 19356530
references.citation: Radiology. 2004 Mar;230(3):845-51
references.pmid: 14990846
references.citation: Circulation. 1996 Dec 15;94(12):3318-26
references.pmid: 8989146
references.citation: Invest Radiol. 1978 Mar-Apr;13(2):103-9
references.pmid: 77854
references.citation: Can J Cardiol. 1990 Dec;6(10):439-44
references.pmid: 2148709
references.citation: J Magn Reson Imaging. 2008 Jan;27(1):229-38
references.pmid: 18050331
references.citation: Magn Reson Med. 2007 Aug;58(2):365-72
references.pmid: 17654582
references.citation: Magn Reson Imaging. 1993;11(2):207-18
references.pmid: 8455431