Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats.
This work attempted to "biochemically" map the brain structures that are recruited at the different stages of pentylenetetrazole (PTZ) kindling (in a model of temporal lobe epilepsy induced by a repeated, systemic administration of PTZ, at a subconvulsive dose of 35 mg/kg). We observed substantial changes in the levels of noradrenaline (NA), 5-hydroxytryptamine (5-HT), dopamine (DA), and their metabolites in the brain structures known to be recruited in the course of kindling, i.e., the piriform, entorhinal and prefrontal cortices, and the hippocampus (in vitro). Kindling of seizures induced time-, seizure-, and structure-dependent increases in the local levels of NA, 5-HT, 5-hydroxyindolacetic acid, DA, homovanillic acid, and 3,4-dihydroxyphenylacetic acid. Surprisingly, limited changes in monoamines (NA and 5-HT) were found in the amygdala. The most potent and widespread effects concerned the serotonergic system, indicating a possible protective role of its enhanced activity in the control of the kindling of seizures. These new data indicate a pattern of changes in the basal activity of local monoaminergic innervation of brain limbic structures, accompanying the induction and propagation of seizures.
Szyndler
Janusz
J
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26/28 Krakowskie Przedmieście Street, 00-927 Warsaw, Poland. jszyndler@yahoo.com
Maciejak
Piotr
P
Turzyńska
Danuta
D
Sobolewska
Alicja
A
Bidziński
Andrzej
A
Płaźnik
Adam
A
D000704:Analysis of Variance; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004195:Disease Models, Animal; D004563:Electrochemistry / Q000379:methods; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
D015306:Biogenic Monoamines; D010433:Pentylenetetrazole
Neuroscience. 1990;34(1):209-17
2139189
Epilepsy Res. 2007 Sep;76(2-3):93-102
17689928
Pharmacol Biochem Behav. 2000 Jun;66(2):425-8
10880700
Eur J Pharmacol. 1998 Jun 5;350(2-3):181-8
9696406
Synapse. 1997 Aug;26(4):351-8
9215594
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8712-5
3120197
Life Sci. 1996;59(21):1763-71
8937503
Br J Pharmacol. 2001 Oct;134(3):507-20
11588104
J Neurochem. 1992 Nov;59(5):1702-8
1402915
Ann N Y Acad Sci. 1978 Jun 12;305:437-56
280255
Neurochem Res. 1994 Sep;19(9):1139-43
7824066
Brain Res. 1994 Jul 18;651(1-2):337-41
7922584
Exp Neurol. 1986 Nov;94(2):379-90
3095132
Psychopharmacology (Berl). 1990;100(1):60-5
1688661
Epilepsy Behav. 2005 Dec;7(4):602-19
16169281
Eur J Pharmacol. 1992 Nov 10;222(2-3):227-32
1451735
J Chromatogr. 1986 Jun 6;360(1):211-8
3733945
Brain Res. 1992 Jul 3;584(1-2):36-44
1515952
Brain Res. 1997 Feb 7;747(2):338-42
9046012
J Neurochem. 2004 May;89(4):834-43
15140183
Exp Neurol. 1979 Mar;63(3):527-44
428481
Neuropharmacology. 1988 Oct;27(10):1081-4
3148871
Brain Res. 1995 Jan 16;669(2):176-82
7712172
J Pharmacol Exp Ther. 1992 Feb;260(2):533-40
1738103
Neurology. 2002 Apr 23;58(8 Suppl 5):S27-39
11971130
Brain Res Bull. 1979 Jan-Feb;4(1):1-7
157185
Brain Res. 1986 Oct 22;385(2):212-8
2430666
Neuropharmacology. 1984 Sep;23(9):1041-8
6083501
Synapse. 1996 Feb;22(2):159-94
8787131
Crit Rev Neurobiol. 1999;13(4):317-56
11028680
Exp Neurol. 1982 Oct;78(1):158-66
7117477
Neuroscience. 1993 Mar;53(2):425-31
8098511
Brain Res. 1993 Jan 8;600(1):63-73
8422591
J Neurophysiol. 1986 Jun;55(6):1295-307
3016209
Epilepsia. 1998 Jul;39(7):709-14
9670898
Epilepsia. 1993 Mar-Apr;34(2):381-4
8384110
Neuropsychopharmacology. 1992 Nov;7(3):189-95
1382432
Neurology. 1995 Oct;45(10):1926-7
7477995
Exp Neurol. 1982 Sep;77(3):700-4
6811306
Brain Res. 1975 Aug 22;94(1):115-131
167913
Epilepsia. 1982 Aug;23(4):359-66
6284498
Nature. 1987 Jul 2-8;328(6125):73-7
3600775
Epilepsy Res. 1987 Jan;1(1):40-5
3504382
J Neural Transm Park Dis Dement Sect. 1993;5(2):89-100
8101446
Neuroscience. 2004;126(3):727-41
15183521
J Pharmacol Exp Ther. 1989 Apr;249(1):229-35
2709332
Brain Res. 1972 Nov 27;47(1):262-8
4641271
Neuropharmacology. 1973 Jul;12(7):681-92
4730377
Brain Res. 2001 Feb 16;892(1):176-92
11172762
Epilepsy Behav. 2009 Oct;16(2):216-24
19713157
Br J Pharmacol. 1995 Aug;115(7):1314-8
7582562
Pharmacol Toxicol. 1993 Apr-May;72(4-5):213-20
8103921
Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):917-30
8539428
Epilepsy Res. 2008 Dec;82(2-3):194-9
18845420
Neurosci Lett. 1999 Feb 12;261(1-2):89-92
10081934