title: The potential economic value of a Staphylococcus aureus vaccine for neonates.
abstract: The continuing morbidity and mortality associated with Staphylococcus aureus (S. aureus) infections, especially methicillin-resistant S. aureus (MRSA) infections, have motivated calls to make S. aureus vaccine development a research priority. We developed a decision analytic computer simulation model to determine the potential economic impact of a S. aureus vaccine for neonates. Our results suggest that a S. aureus vaccine for the neonatal population would be strongly cost-effective (and in many situations dominant) over a wide range of vaccine efficacies (down to 10%) for vaccine costs (<or=$500), and S. aureus attack rates (>or=1%).
authors.affiliation: Applied Modeling, Public Health Computational and Operations Research (PHICOR), Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu
authors.forename: Bruce Y
authors.initials: BY
authors.lastname: Lee
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Ufberg
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Bailey
authors.forename: Ann E
authors.initials: AE
authors.lastname: Wiringa
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Smith
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Nowalk
authors.forename: Conor
authors.initials: C
authors.lastname: Higgins
authors.forename: Angela R
authors.initials: AR
authors.lastname: Wateska
authors.forename: Robert R
authors.initials: RR
authors.lastname: Muder
mesh_terms: D003198:Computer Simulation; D003362:Cost-Benefit Analysis; D006801:Humans; D007231:Infant, Newborn; D055624:Methicillin-Resistant Staphylococcus aureus / Q000276:immunology; D018803:Models, Economic; D013203:Staphylococcal Infections / Q000191:economics / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000191:economics*
chemical_list: D013209:Staphylococcal Vaccines
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