NF-kappaB signaling modulation by EBV and KSHV.
The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.
de Oliveira
Deilson Elgui
DE
Department of Pathology, Botucatu School of Medicine, Sao Paulo State University (UNESP), Rubiao Junior, s/n - Botucatu, SP 18618-000, Brazil.
Ballon
Gianna
G
Cesarman
Ethel
E
D000818:Animals; D002471:Cell Transformation, Neoplastic; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015967:Gene Expression Regulation, Viral; D006566:Herpesviridae Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D015398:Signal Transduction
D036341:Intercellular Signaling Peptides and Proteins; D016328:NF-kappa B