title: [AIDS related lymphomas: Histopathological subtypes and association with Epstein Barr virus and Human Herpes virus type-8].
abstract: Non-Hodgkin lymphomas (NHL) of the B-cell type are the second most common neoplasm among patients with human immunodeficiency virus (HIV) infection and AIDS. Here, we evaluated 48 cases of AIDS-related lymphomas (ARL) diagnosed at the Histopathological Division of the Instituto de Investigaciones Hematológicas of the National Academy of Medicine. Five were females and 43 were males with a median of age of 37 years at the time of the diagnosis. Micrometer sections were prepared and stained with hematoxilin-eosin; immunohistochemical examination for the presence of Epstein-Barr virus (EBV) was carried out in 48/48 cases. Additionally, biotinilated oligonucleotides were used to determine the presence of DNA of the Human Herpes virus type-8 (HHV-8) in 14/14 biopsy smears corresponding to plasmablastic lymphomas (PL). All were fenotype B cell lymphomas with an aggressive course and advanced neoplasm disease at the time of diagnosis. Virological findings showed the strong association between EBV and AIDS-related NHL. According to the histopathological subtype, the EBV genome was detected in 16/21 (76%) diffuse large B cell lymphomas, 1/3 Burkitt lymphoma and 3/4 (75%) of primary central nervous system lymphomas. Globally, EBV genome was detected in 20/28 NHL of this series. Detection of HHV-8 was negative in all cases of PL. Hodgkin lymphoma were more frequent in males 18/20 (90%), with an aggressive clinical course and a significant predominance of the subtypes associated with worse prognosis (90% of cases). We detected a significant association between EBV and HL (90% of cases). We consider that all cases of AIDS related lymphomas should be assessed for the presence of EBV because its presence may play a role in the prognosis.
authors.affiliation: Hospital de Enfermedades Infecciosas F. J. Muniz, Buenos Aires. marcellocorti@fibertel.com.ar
authors.forename: Marcelo
authors.initials: M
authors.lastname: Corti
authors.forename: Marcela
authors.initials: M
authors.lastname: de Dios Soler
authors.forename: Patricia
authors.initials: P
authors.lastname: Bare
authors.forename: María F
authors.initials: MF
authors.lastname: Villafañe
authors.forename: Miguel
authors.initials: M
authors.lastname: De Tezanos Pinto
authors.forename: Raúl
authors.initials: R
authors.lastname: Perez Bianco
authors.forename: Marina
authors.initials: M
authors.lastname: Narbaitz
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016483:Lymphoma, AIDS-Related / Q000145:classification / Q000473:pathology / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D004279:DNA, Viral