title: Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as a type I diabetes models.
abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic beta-cells. Several animal models have been used to study T1DM. Among them, mini-pig seems to be a useful model of diabetes because of its similarities in anatomy and physiology to humans. The purpose of this study is to analyze differentially expressed pancreatic proteins in streptozotocin (STZ)-induced mini-pig T1DM model. The pancreas proteins from mini-pigs treated with STZ were separated by 2-dimensional gel electrophoresis and eleven protein spots were found to be altered significantly compared with control mini-pigs. The data in this study from proteomic analysis provide a valuable resource for the further understanding of T1DM pathomechanism.
authors.affiliation: Medical Proteomics Research Center, KRIBB, Daejeon, Korea.
authors.forename: Phil Young
authors.initials: PY
authors.lastname: Lee
authors.forename: Sung Goo
authors.initials: SG
authors.lastname: Park
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Myung Sup
authors.initials: MS
authors.lastname: Lee
authors.forename: Sang J
authors.initials: SJ
authors.lastname: Chung
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Lee
authors.forename: Dae Yeul
authors.initials: DY
authors.lastname: Yu
authors.forename: Kwang-Hee
authors.initials: KH
authors.lastname: Bae
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D013058:Mass Spectrometry; D010179:Pancreas / Q000378:metabolism*; D040901:Proteomics / Q000379:methods; D013311:Streptozocin; D013552:Swine; D013556:Swine, Miniature
chemical_list: D013311:Streptozocin