Epilepsy as a dynamic disease: a tutorial of the past with an eye to the future.
How can clinical epileptologists and computational neuroscientists learn to function together within the confines of interdisciplinary teams to develop new and more effective treatment strategies for epilepsy? Here we introduce epileptologists to the way modelers think about epilepsy as a dynamic disease. Not only is there terminology to be learned, but also it is necessary to identify those areas where clinical input might be expected to have the greatest impact. It is concluded that both groups have major roles to play in educating, evaluating, and shaping the direction of the efforts of each other.
Milton
John G
JG
Joint Science Department, W.M. Keck Science Center, The Claremont Colleges, 925 North Mills Ave., Claremont, CA 91711, USA. jmilton@jsd.claremont.edu
D001921:Brain / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology*