Pro/Anti-inflammatory cytokine imbalance in postischemic left ventricular remodeling.
OBJECTIVE
Cytokines play an important role in left ventricular remodeling consequent to myocardial ischemia. The aim of this study was to correlate cytokine production and lymphocyte apoptosis to post-ischemic left ventricular remodeling in patients affected by acute myocardial infarction (AMI) undergoing primary cutaneous angioplasty (PCI).


METHODS
In 40 patients, affected by AMI and undergoing PCI, we evaluated peripheral blood mononuclear cells (PBMCs), tumor necrosis factor-alpha (TNF-alpha) and interleukin 10 (IL10) production and apoptosis on day 1, day 3, day 7, 1 month and 6 months after PCI. Patients were divided into two subgroups of remodeling or not remodeling by echocardiographic criteria.


RESULTS
In the subgroup of remodeling patients, at each timepoint TNF-alpha production was increased significantly in comparison with the subgroup of not remodeling patients. IL10 production was statistically lower in remodeling subjects than in not remodeling ones 1 and 6 months after reperfusion. There were no differences between the two groups as regards lymphomonocyte apoptosis.


CONCLUSIONS
We found an increased production of pro-inflammatory cytokine TNF-alpha and a corresponding decrease of anti-inflammatory/regulatory cytokine IL10 in remodeling patients and we concluded that this cytokine imbalance resulted in pro-inflammatory effects which might contribute to the progression of left ventricular remodeling.
Pasqui
Anna Laura
AL
Division of Internal Medicine, Department of Clinical Medicine and Immunology, University of Siena, V. le Bracci, 53100 Siena, Italy.
Laura
Pasqui Anna
PA
Di Renzo
Michela
M
Michela
Di Renzo
DR
Maffei
Silvia
S
Silvia
Maffei
M
Pastorelli
Marcello
M
Marcello
Pastorelli
P
Pompella
Gerarda
G
Gerarda
Pompella
P
Auteri
Alberto
A
Alberto
Auteri
A
Puccetti
Luca
L
Luca
Puccetti
P
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D004452:Echocardiography; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D009203:Myocardial Infarction / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D020257:Ventricular Remodeling / Q000276:immunology*
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
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