title: Beta-carboline alkaloids from the stems of Picrasma quassioides.
abstract: Five new beta-carboline alkaloids, 6,12-dimethoxy-3-(2-hydroxylethyl)-beta-carboline (1), 3,10-dihydroxy-beta-carboline (2), 6,12-dimethoxy-3-(1-hydroxylethyl)-beta-carboline (3), 6,12-dimethoxy-3-(1,2-dihydroxylethyl)-beta-carboline (4), and 6-methoxy-3-(2-hydroxyl-1-ethoxylethyl)-beta-carboline (5), and two new natural products, 6-methoxy-12-hydroxy-3-methoxycarbonyl-beta-carboline (6) and 3-hydroxy-beta-carboline (7) were isolated from the stems of Picrasma quassioides along with 16 known beta-carboline alkaloids (8-23). The structures of new compounds were determined by extensive spectroscopic analyses, and the 1D and 2D NMR data of compounds 6, 7 and 10 were reported for the first time. The bioassays showed that only compounds 14 and 16 could enhance the differentiation of 3T3-L1 preadiocytes accompanied by secretion of adiponectin proteins among these 23 compounds.
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Li
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ohmura
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D032270:Picrasma / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002243:Carbolines; D010936:Plant Extracts