Cytotoxic, radical scavenging and antimicrobial activities of sesquiterpenoids from the Tahitian liverwort Mastigophora diclados (Brid.) Nees (Mastigophoraceae).
A drimane, (+)-drimenol (1), five known herbertanes, (-)-alpha-herbertenol (2), (-)-herbertenediol (3), mastigophorene A (4), (-)-mastigophorene C (5) and (-)-mastigophorene D (6), a pimarane, (-)-ent-pimara-8(14),15-dien-19-oic acid (7), and two eudesmanolides, (-)-diplophyllolide A (8) and (-)-diplophyllin (9) were isolated from the Tahitian Mastigophora diclados (Brid.) Nees. Herbertane sesquiterpenes (2, 3, 5 and 6) showed cytotoxicity against HL-60 and KB cell lines, radical scavenging activity and antimicrobial activity against Bacillus subtilis. (-)-Diplophyllolide A (8) also exhibited cytotoxicity against HL-60 and KB cell lines.
Komala
Ismiarni
I
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan.
Ito
Takuya
T
Nagashima
Fumihiro
F
Yagi
Yasuyuki
Y
Asakawa
Yoshinori
Y
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D018922:HL-60 Cells; D035926:Hepatophyta / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D007624:KB Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D011114:Polynesia; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity
D000890:Anti-Infective Agents; D003603:Cytotoxins; D016166:Free Radical Scavengers; D010936:Plant Extracts; D012717:Sesquiterpenes
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