Angiogenesis as a potential target of pharmaconutrients in cancer therapy.
OBJECTIVE
The aim of this review is to provide insight into tumor angiogenesis inhibition by pharmaconutrients through description of the most relevant and recent findings in cancer research.


RESULTS
Cancer growth needs oxygen and nutrients supplied through blood vessels to the tumor site. New vessel formation named angiogenesis can be prevented to avoid cancer invasion. Epidemiological studies suggested that specific food intakes could decrease incidence of many cancers. Recently, scientists were interested in the potential antitumor effects of nutrients because of their safety and general acceptance. Many excellent publications demonstrated that a large class of natural compounds including pharmaconutrients exhibits antitumoral activities in selected cancer types. This review focuses on the antiangiogenic role of natural products in cancer treatment, used alone or in combination with conventional chemotherapy.


CONCLUSIONS
There is strong evidence that natural diets influence cancer development by modulating signaling pathways. Our goal is to highlight the specific impact of specific nutrients in the modulation of vascular network leading to tumor angiogenesis inhibition.
Granci
Virginie
V
Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.
Dupertuis
Yves M
YM
Pichard
Claude
C
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols; D015398:Signal Transduction / Q000187:drug effects*
D020533:Angiogenesis Inhibitors; D015525:Fatty Acids, Omega-3; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols