Asking good clinical research questions and choosing the right study design.
Clinicians and researchers seek answers to clinical research questions, primarily by accessing the results of clinical research studies. This paper moves the focus of research enquiry from getting answers to developing good clinical research questions. Using worked examples, the steps involved in refining questions drawn from various sources to create 'answerable' clinical research questions using the 'PICO' principle are described. Issues to consider in prioritising clinical research questions are also identified. Theoretical and practical considerations involved in choosing the right study design for a clinical research question are then discussed using the worked examples. These include:
Bragge
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National Trauma Research Institute & Monash University, Level 6, 99 Commercial Road, Melbourne, VIC 3004, Australia. peter.bragge@med.monash.edu.au
D035843:Biomedical Research / Q000592:standards*; D001930:Brain Injuries; D006801:Humans; D012107:Research Design / Q000592:standards*; D012108:Research Personnel / Q000592:standards*