title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome--a pilot study.
abstract: BACKGROUND
  Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It is shed, in part, by proteases and released as soluble LOX-1 (sLOX-1), which is a specific and sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS.
  
  
  RESULTS
  ACS patients undergoing emergency percutaneous coronary intervention and measurement of circulating sLOX-1 were followed (median: 896 days). Among 94 patients, 13 had ACS recurrence or died (re-ACS/death group). None of age, sex, lipid profile or prevalence of diabetes, smoking or hypertension was significantly different between the re-ACS/death group and the event-free survival group. Circulating sLOX-1 levels, but not those of high-sensitivity C-reactive protein (hs-CRP) or troponin T (TnT), were significantly (P<0.005) higher in the re-ACS/death group than in the event-free survival group. Kaplan-Meier survival curves showed that ACS patients with sLOX-1 values in the highest quartile or tertile had more frequent and earlier ACS recurrence or death. Receiver-operating characteristic curves for prediction of re-ACS or death showed higher sensitivity and specificity for sLOX-1 (area under the curve for sLOX-1, hs-CRP and TnT: 0.764, 0.658 and 0.524, respectively).
  
  
  CONCLUSIONS
  Circulating sLOX-1, a diagnostic biomarker of ACS, also predicts ACS recurrence or death.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. nkume@kuhp.kyoto-u.ac.jp
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kume
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Mitsuoka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Hayashida
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D006801:Humans; D053208:Kaplan-Meier Estimate; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012008:Recurrence; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: D015415:Biomarkers; D051127:Scavenger Receptors, Class E