title: Influence of TGFB1+869T>C functional polymorphism in non-small cell lung cancer (NSCLC) risk.
abstract: OBJECTIVE
  Lung cancer is the third most common type of cancer in Europe and is the first cause of death by cancer worldwide. Non-small cell lung cancer accounts for 75-85% of all histological types of LC. The transforming growth factor beta 1 is a multifunctional regulatory polypeptide that controls many aspects of cellular function (cellular proliferation, differentiation, migration, apoptosis, immune surveillance). TGFB1+869T>C is a functional polymorphism described in TGFB1 gene and this transition has been associated with higher circulating levels of TGFß1 that may modulate cellular microenvironment and consequently LC development and prognosis.
  
  
  METHODS
  We studied TGFB + 869T > C functional polymorphism by allelic discrimination using 7300 real-time polymerase chain reaction system in 305 patients with NSCLC and 380 healthy individuals.
  
  
  RESULTS
  We found an increased risk for C carriers to develop NSCLC, both epidermoid NSCLC and non-epidermoid NSCLC (odds ratio (OR) = 2.03, P < 0.0001, OR = 2.37, P < 0.001 and OR = 1.83, P = 0.001, respectively). TGFB1+869T>C functional polymorphism may influence NSCLC susceptibility with impact in cellular microenvironment.
  
  
  CONCLUSIONS
  Our results suggest that individual differences influence the susceptibility to LC and tumoral behavior. This genetic profiling may help define higher risk groups for an individualized chemoprevention strategy and therapy.
authors.affiliation: Molecular Oncology GRP-CI, Portuguese Institute of Oncology, Porto Centre, Edifício Laboratórios, 4º piso, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Teixeira
authors.forename: António
authors.initials: A
authors.lastname: Araújo
authors.forename: Ana
authors.initials: A
authors.lastname: Coelho
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ribeiro
authors.forename: Mónica
authors.initials: M
authors.lastname: Gomes
authors.forename: Carina
authors.initials: C
authors.lastname: Pereira
authors.forename: Rui
authors.initials: R
authors.lastname: Medeiros
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1
references.citation: Dis Markers. 2005;21(3):157-65
references.pmid: 16276011
references.citation: J Clin Oncol. 2005 Mar 20;23(9):2078-93
references.pmid: 15774796
references.citation: Cancer Genet Cytogenet. 2006 Aug;169(1):39-44
references.pmid: 16875935
references.citation: Nat Rev Cancer. 2003 Nov;3(11):807-21
references.pmid: 14557817
references.citation: Expert Opin Biol Ther. 2003 Apr;3(2):251-61
references.pmid: 12662140
references.citation: J Cancer Res Clin Oncol. 2008 Mar;134(3):345-51
references.pmid: 17680270
references.citation: Cancer Res. 1999 Oct 1;59(19):4834-42
references.pmid: 10519393
references.citation: Cancer Biol Ther. 2004 Mar;3(3):276-83
references.pmid: 15034302
references.citation: Lung Cancer. 2006 Apr;52(1):1-7
references.pmid: 16499994
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1303-5
references.pmid: 17548703
references.citation: Circulation. 2000 Jun 20;101(24):2783-7
references.pmid: 10859282
references.citation: Clin Cancer Res. 2008 Aug 1;14(15):4961-70
references.pmid: 18676771
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):759-64
references.pmid: 15159307
references.citation: Cancer Res. 1996 Dec 15;56(24):5583-5
references.pmid: 8971158
references.citation: Curr Cancer Drug Targets. 2006 Nov;6(7):565-78
references.pmid: 17100564
references.citation: Cancer Res. 1996 Jun 15;56(12):2718-20
references.pmid: 8665501
references.citation: Microsc Res Tech. 2001 Feb 15;52(4):363-73
references.pmid: 11170295
references.citation: Cell Biochem Funct. 2008 Apr;26(3):283-90
references.pmid: 17654453
references.citation: Cancer. 1999 Nov 1;86(9):1712-9
references.pmid: 10547543
references.citation: Carcinogenesis. 2007 Sep;28(9):1965-70
references.pmid: 17615257
references.citation: Clin Chim Acta. 2007 May 1;380(1-2):165-9
references.pmid: 17368597
references.citation: Anticancer Res. 1999 Jan-Feb;19(1A):301-6
references.pmid: 10226558
references.citation: Carcinogenesis. 2004 Feb;25(2):237-40
references.pmid: 14604900
references.citation: Curr Opin Pulm Med. 2004 Jul;10(4):279-83
references.pmid: 15220752
references.citation: Pharmacogenomics J. 2009 Oct;9(5):341-6
references.pmid: 19488063
references.citation: N Engl J Med. 2004 Jan 22;350(4):379-92
references.pmid: 14736930
references.citation: Hum Mol Genet. 1999 Jan;8(1):93-7
references.pmid: 9887336
references.citation: Int J Cancer. 2004 Oct 20;112(1):94-9
references.pmid: 15305380
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):412-5
references.pmid: 15006917