title: Pituitary-dependent hyperadrenocorticism and generalised toxoplasmosis in a cat with neurological signs.
abstract: A 12-year-old female neutered cat presented with acute onset unilateral vestibular syndrome, a spontaneous cutaneous wound, polyuria, polydipsia, and diabetes mellitus. Hyperadrenocorticism was demonstrated by means of hyper-responsiveness to adrenocorticotropic hormone stimulation, elevated urine cortisol-to-creatinine ratio, bilaterally enlarged adrenal glands on abdominal ultrasound, and pituitary enlargement on computed tomography imaging. The cat was euthanased and post-mortem histological examination revealed feline skin fragility syndrome; confirmed a pituitary cromophobe macroadenoma; and generalised toxoplasmosis with tachyzoites in the pancreas, bowel and brain. This report is the first to describe the concurrence of macroadenoma pituitary-dependent hyperadrenocorticism and generalised toxoplasmosis in a cat with central vestibular syndrome.
authors.affiliation: Dipartimento di Scienze Cliniche Veterinarie, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, via Celoria, 10, 20133 Milano, Italy. eva.spada@unimi.it
authors.forename: Eva
authors.initials: E
authors.lastname: Spada
authors.forename: Daniela
authors.initials: D
authors.lastname: Proverbio
authors.forename: Chiara
authors.initials: C
authors.lastname: Giudice
authors.forename: Mauro
authors.initials: M
authors.lastname: DiGiancamillo
authors.forename: Matteo
authors.initials: M
authors.lastname: Lodi
authors.forename: Roberta
authors.initials: R
authors.lastname: Perego
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats; D037901:Euthanasia, Animal; D005260:Female; D010902:Pituitary Gland / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D014124:Toxoplasmosis, Animal / Q000150:complications* / Q000175:diagnosis; D015837:Vestibular Diseases / Q000150:complications / Q000662:veterinary*
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