Ligand binding prediction for BRCA1, a key molecule in the pathogenesis of breast cancer.
BACKGROUND
Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention.


METHODS
In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool.


RESULTS
According to this study, 10 strong possible ligands were identified.


CONCLUSIONS
These sites can be useful for further drug development studies.
Wiwanitkit
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Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand.
D019313:BRCA1 Protein / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D019295:Computational Biology; D015195:Drug Design; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011379:Prognosis
D019313:BRCA1 Protein; D014408:Biomarkers, Tumor