Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.
Recent genome-wide association study using four prospective population-based cohorts identified two single-nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579, to be significantly associated with the incidence of atherothrombotic stroke. To examine the association of these SNPs with atherothrombotic stroke in the Japanese population, we carried out a case-control association study using a total of 3784 cases and 3102 controls. We also examined the effect of these SNPs on the subtypes of ischemic stroke. Association analysis was carried out using logistic regression model after adjustment of age, sex and cardiovascular risk factors. Rs12425791 was significantly associated with atherothrombotic stroke (P=0.0084, odds ratio (OR)=1.15). When we analyzed effects of rs12425791 on ischemic stroke subtypes, rs12425791 was significantly associated with both small-artery occlusion (P=0.015, OR=1.15) and large-artery atherosclerosis (P=0.024, OR=1.19). Rs11833579 showed no association with atherothrombotic stroke or its subtypes in our population. Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population.
Matsushita
Tomonaga
T
Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN Yokohama Institute, Kanagawa, Japan. matsushita@src.riken.jp
Umeno
Junji
J
Hirakawa
Yoichiro
Y
Yonemoto
Koji
K
Ashikawa
Kyota
K
Amitani
Hanae
H
Ninomiya
Toshiharu
T
Hata
Jun
J
Doi
Yasufumi
Y
Kitazono
Takanari
T
Iida
Mitsuo
M
Nakamura
Yusuke
Y
Kiyohara
Yutaka
Y
Kubo
Michiaki
M
D000368:Aged; D044466:Asian People / Q000235:genetics*; D050197:Atherosclerosis / Q000150:complications* / Q000235:genetics; D002545:Brain Ischemia / Q000145:classification / Q000150:complications / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000145:classification / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000150:complications* / Q000235:genetics