title: Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.
abstract: Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.
authors.affiliation: Department of Chemistry U. Schiff, Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles (HeteroBioLab), University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Florence, Italy. francesca.cardona@unifi.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Cardona
authors.forename: Andrea
authors.initials: A
authors.lastname: Goti
authors.forename: Camilla
authors.initials: C
authors.lastname: Parmeggiani
authors.forename: Paolo
authors.initials: P
authors.lastname: Parenti
authors.forename: Matilde
authors.initials: M
authors.lastname: Forcella
authors.forename: Paola
authors.initials: P
authors.lastname: Fusi
authors.forename: Laura
authors.initials: L
authors.lastname: Cipolla
authors.forename: Shirley M
authors.initials: SM
authors.lastname: Roberts
authors.forename: Gideon J
authors.initials: GJ
authors.lastname: Davies
authors.forename: Tracey M
authors.initials: TM
authors.lastname: Gloster
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D001665:Binding Sites; D002683:Chironomidae / Q000201:enzymology; D003198:Computer Simulation; D004791:Enzyme Inhibitors / Q000737:chemistry*; D004926:Escherichia coli / Q000201:enzymology; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry*; D007668:Kidney / Q000201:enzymology; D011758:Pyrroles / Q000737:chemistry*; D013552:Swine; D014198:Trehalase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D004791:Enzyme Inhibitors; D005960:Glucosides; D007306:Insecticides; D011758:Pyrroles; C409108:casuarine; D014198:Trehalase