title: Methodological considerations treatment trials for persons personality disorder.
abstract: BACKGROUND
  The National Institute of Mental Health convened an international group of experts to examine the conduct of treatment trials for persons with borderline personality disorder (BPD). The rapid growth of treatment research had led to the recognition that investigators face unique methodological issues with these challenging patients.
  
  
  METHODS
  Conference members reviewed critical aspects of psychotherapy and pharmacotherapy trial design for patients with BPD.
  
  
  RESULTS
  This article summarizes discussions held on March 17-18, 2005.
  
  
  CONCLUSIONS
  This paper addresses the most pressing issues in sample selection and trial design pertaining to BPD; issues that have bedeviled both investigators submitting applications and reviewers trying to assess the merit of these grants. By disseminating this work, conference members hope to make this process more consistent and productive for all concerned.
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA, USA. zanarini@mclean.harvard.edu
authors.forename: Mary C
authors.initials: MC
authors.lastname: Zanarini
authors.forename: Barbara
authors.initials: B
authors.lastname: Stanley
authors.forename: Donald W
authors.initials: DW
authors.lastname: Black
authors.forename: John C
authors.initials: JC
authors.lastname: Markowitz
authors.forename: Marianne
authors.initials: M
authors.lastname: Goodman
authors.forename: Paul
authors.initials: P
authors.lastname: Pilkonis
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Lynch
authors.forename: Kenneth
authors.initials: K
authors.lastname: Levy
authors.forename: Peter
authors.initials: P
authors.lastname: Fonagy
authors.forename: Martin
authors.initials: M
authors.lastname: Bohus
authors.forename: Joan
authors.initials: J
authors.lastname: Farrell
authors.forename: Charles
authors.initials: C
authors.lastname: Sanislow
mesh_terms: D001883:Borderline Personality Disorder / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002986:Clinical Trials as Topic; D006801:Humans; D018579:Patient Selection; D011613:Psychotherapy; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012107:Research Design
chemical_list: D011619:Psychotropic Drugs
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