Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4.
IgG4-positive plasma cell infiltration into multiple organs or tissues, such as the pancreas and salivary glands, associated with increased serum levels of IgG4 is a characteristic finding seen in IgG4-related disease. Affected organs may appear tumorous as a result of chronic inflammatory processes accompanied with progressive fibrosis. Recent cases of this disorder in which the pituitary gland was affected include cases of diffuse enlargement of the pituitary and/or its stalk associated with central diabetes insipidus and/or impaired anterior hormone production. Here we report two such cases, as well as two additional previously undiagnosed cases found in our database. In order to make a correct diagnosis of pituitary lesion involvement with IgG4-related disease, the clinical background and concomitant disorders should be carefully taken into consideration and the measurement of serum levels of IgG4 seems to be useful.
Haraguchi
Ai
A
First Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Era
Ai
A
Yasui
Junichi
J
Ando
Takao
T
Ueki
Ikuko
I
Horie
Ichiro
I
Imaizumi
Misa
M
Usa
Toshiro
T
Abe
Kuniko
K
Origuchi
Tomoki
T
Eguchi
Katsumi
K
D000368:Aged; D003919:Diabetes Insipidus / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D010907:Pituitary Hormones / Q000097:blood; D011239:Prednisolone / Q000627:therapeutic use
D007074:Immunoglobulin G; D010907:Pituitary Hormones; D011239:Prednisolone