title: PDCD1 gene polymorphisms in different Mexican ethnic groups and their role in the susceptibility to hypersensitivity pneumonitis.
abstract: OBJECTIVE
  Hypersensitivity pneumonitis (HP) is an immunological disorder caused by antigen exposure in susceptible individuals. The PDCD1 polymorphisms, PD1.3 and PD1.5 have been associated with the susceptibility to inflammatory disorders. This study was conducted to test whether the PD1.3 and PD1.5 polymorphisms are associated with HP in Mexican patients and to explore the distribution of these polymorphisms in different Mexican ethnic groups.
  
  
  METHODS
  We studied 98 Mexican patients with HP and 92 healthy Mexican controls. Also, 156 healthy Amerindian individuals from two ethnic groups were included (96 Mayans and 60 Mayos). Polymorphisms were determined by TaqMan 5' nuclease assays.
  
  
  RESULTS
  Significant differences in the distribution of the PD1.3 and PD1.5 genotypes between HP patients and healthy Mestizo controls were not found. We observed a significantly different distribution of these polymorphisms in Mexican Mestizos when compared to the Amerindians.
  
  
  CONCLUSIONS
  We found no association between PD1 polymorphism and HP; however the distribution of these polymorphisms was different in Mexican Mestizos and Amerindians.
authors.affiliation: Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, 14080, Mexico. joazu@yahoo.com
authors.forename: Joaquín
authors.initials: J
authors.lastname: Zúñiga
authors.forename: Diana
authors.initials: D
authors.lastname: Torres-García
authors.forename: Luis
authors.initials: L
authors.lastname: Jimenez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Ramírez-Martínez
authors.forename: Francisco
authors.initials: F
authors.lastname: Juárez-Nicolás
authors.forename: Fabiola
authors.initials: F
authors.lastname: Mujica
authors.forename: Lina T
authors.initials: LT
authors.lastname: Romero
authors.forename: Victor
authors.initials: V
authors.lastname: Acuña
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cruz-Lagunas
authors.forename: David
authors.initials: D
authors.lastname: Ruíz-Saavedra
authors.forename: Carlos
authors.initials: C
authors.lastname: Ramos
authors.forename: Martha
authors.initials: M
authors.lastname: Montaño
authors.forename: Criselda
authors.initials: C
authors.lastname: Mendoza-Milla
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: Annie
authors.initials: A
authors.lastname: Pardo
authors.forename: Moises
authors.initials: M
authors.lastname: Selman
mesh_terms: D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000235:genetics* / Q000276:immunology; D015703:Antigens, CD / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000208:ethnology; D018895:Microsatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D061026:Programmed Cell Death 1 Receptor
chemical_list: D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D005819:Genetic Markers; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor