title: Biomimetic nanoparticles: preparation, characterization and biomedical applications.
abstract: Mimicking nature is a powerful approach for developing novel lipid-based devices for drug and vaccine delivery. In this review, biomimetic assemblies based on natural or synthetic lipids by themselves or associated to silica, latex or drug particles will be discussed. In water, self-assembly of lipid molecules into supramolecular structures is fairly well understood. However, their self-assembly on a solid surface or at an interface remains poorly understood. In certain cases, hydrophobic drug granules can be dispersed in aqueous solution via lipid adsorption surrounding the drug particles as nanocapsules. In other instances, hydrophobic drug molecules attach as monomers to borders of lipid bilayer fragments providing drug formulations that are effective in vivo at low drug-to-lipid-molar ratio. Cationic biomimetic particles offer suitable interfacial environment for adsorption, presentation and targeting of biomolecules in vivo. Thereby antigens can effectively be presented by tailored biomimetic particles for development of vaccines over a range of defined and controllable particle sizes. Biomolecular recognition between receptor and ligand can be reconstituted by means of receptor immobilization into supported lipidic bilayers allowing isolation and characterization of signal transduction steps.
authors.affiliation: Biocolloids Lab, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. amcr@usp.br
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Carmona-Ribeiro
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D004337:Drug Carriers
references.citation: Expert Rev Vaccines. 2003 Apr;2(2):197-203
references.pmid: 12899571
references.citation: J Infect Dis. 1996 Dec;174(6):1168-75
references.pmid: 8940205
references.citation: Nat Biotechnol. 1999 Nov;17(11):1075-81
references.pmid: 10545912
references.citation: Biochemistry. 2007 Feb 27;46(8):2059-69
references.pmid: 17263563
references.citation: Res Immunol. 1992 Jun;143(5):494-503; discussion 574-6
references.pmid: 1439129
references.citation: J Lipid Res. 1997 Oct;38(10):2003-11
references.pmid: 9374123
references.citation: Curr Med Chem. 2006;13(12):1359-70
references.pmid: 16719782
references.citation: J Phys Chem B. 2008 Dec 25;112(51):16422-30
references.pmid: 19367939
references.citation: J Colloid Interface Sci. 2003 Feb 1;258(1):146-54
references.pmid: 12600782
references.citation: Nature. 1966 Apr 16;210(5033):259-61
references.pmid: 4289018
references.citation: Cell Biochem Biophys. 2006;44(3):446-52
references.pmid: 16679532
references.citation: Biophys J. 1995 Oct;69(4):1447-55
references.pmid: 8534815
references.citation: J Liposome Res. 2007;17(3-4):165-72
references.pmid: 18027236
references.citation: Vaccine. 2005 Jan 11;23(8):975-6
references.pmid: 15620469
references.citation: Nanomedicine (Lond). 2007 Feb;2(1):85-98
references.pmid: 17716195
references.citation: Proc Natl Acad Sci U S A. 1984 Oct;81(19):6159-63
references.pmid: 6333027
references.citation: Biochemistry. 1978 Sep 5;17(18):3759-68
references.pmid: 698196
references.citation: Biochim Biophys Acta. 2007 Jun;1768(6):1518-25
references.pmid: 17451640
references.citation: Anal Chem. 2008 Mar 1;80(5):1806-12
references.pmid: 18232711
references.citation: Vaccine. 2006 Mar 6;24(10):1680-6
references.pmid: 16300864
references.citation: Langmuir. 2004 Oct 26;20(22):9535-40
references.pmid: 15491183
references.citation: Proc Natl Acad Sci U S A. 2002 May 14;99(10):6725-30
references.pmid: 11997441
references.citation: Methods. 2006 Sep;40(1):1-9
references.pmid: 16997708
references.citation: Expert Rev Vaccines. 2003 Apr;2(2):269-83
references.pmid: 12899577
references.citation: Int J Pharm. 2007 Aug 1;340(1-2):216-22
references.pmid: 17452086
references.citation: Vaccine. 2009 Sep 25;27(42):5760-71
references.pmid: 19664738
references.citation: Adv Colloid Interface Sci. 2006 Sep 13;121(1-3):51-75
references.pmid: 16769012
references.citation: Nano Lett. 2005 May;5(5):829-34
references.pmid: 15884879
references.citation: J Am Chem Soc. 2008 Feb 20;130(7):2140-1
references.pmid: 18229924
references.citation: Immunology. 2007 Jun;121(2):216-26
references.pmid: 17302734
references.citation: Trends Biochem Sci. 2008 Jan;33(1):9-19
references.pmid: 18165013
references.citation: Anal Chim Acta. 2007 Apr 18;589(1):76-83
references.pmid: 17397656
references.citation: Biochem Biophys Res Commun. 1978 Apr 28;81(4):1080-6
references.pmid: 666808
references.citation: J Antimicrob Chemother. 2003 Sep;52(3):412-8
references.pmid: 12917237
references.citation: J Am Chem Soc. 2004 Oct 27;126(42):13816-21
references.pmid: 15493941
references.citation: Nat Med. 2002 Jan;8(1):81-4
references.pmid: 11786911
references.citation: J Nanobiotechnology. 2008 May 07;6:6
references.pmid: 18462496
references.citation: Immunol Rev. 2004 Jun;199:191-200
references.pmid: 15233735
references.citation: Colloids Surf B Biointerfaces. 2009 Jul 1;71(2):325-30
references.pmid: 19361963
references.citation: Vaccine. 2002 Jun 21;20(21-22):2743-51
references.pmid: 12034101
references.citation: Immunology. 1966 Oct;11(4):369-86
references.pmid: 5924622
references.citation: Langmuir. 2004 May 11;20(10):3906-12
references.pmid: 15969378
references.citation: Curr Drug Deliv. 2008 Oct;5(4):230-42
references.pmid: 18855591
references.citation: Biochim Biophys Acta. 2000 Nov 23;1508(1-2):146-63
references.pmid: 11090823
references.citation: Biochim Biophys Acta. 1972 Jan 27;260(1):49-58
references.pmid: 5062443
references.citation: Nature. 1982 Mar 11;296(5853):164-5
references.pmid: 7063019
references.citation: Vaccine. 1995 Oct;13(14):1263-76
references.pmid: 8585280
references.citation: Int J Pharm. 2009 Feb 9;367(1-2):187-94
references.pmid: 18930127
references.citation: Lancet Infect Dis. 2004 Feb;4(2):84-90
references.pmid: 14871632
references.citation: FASEB J. 2008 Sep;22(9):3389-402
references.pmid: 18556649
references.citation: Vaccine. 2005 Jul 8;23 Suppl 1:S26-38
references.pmid: 16026906
references.citation: J Colloid Interface Sci. 1997 Sep 1;193(1):104-11
references.pmid: 9299094
references.citation: Curr Drug Deliv. 2005 Oct;2(4):395-400
references.pmid: 16305442
references.citation: Biophys J. 2003 Dec;85(6):3839-47
references.pmid: 14645073
references.citation: Biophys Chem. 2005 Feb 1;113(2):183-92
references.pmid: 15617826
references.citation: Pharm Biotechnol. 1995;6:277-96
references.pmid: 7551221
references.citation: Biophys J. 1985 Jan;47(1):105-13
references.pmid: 3978184
references.citation: Biochim Biophys Acta. 1983 Aug 24;733(1):172-9
references.pmid: 6882751
references.citation: BMC Biotechnol. 2009 Jan 19;9:5
references.pmid: 19152701
references.citation: Vaccine. 2004 Sep 9;22(27-28):3658-68
references.pmid: 15315845
references.citation: J Appl Toxicol. 2002 Sep-Oct;22(5):333-44
references.pmid: 12355563
references.citation: J Antimicrob Chemother. 2006 Jul;58(1):66-75
references.pmid: 16636081
references.citation: Infect Immun. 1997 May;65(5):1710-5
references.pmid: 9125551
references.citation: Adv Drug Deliv Rev. 1998 Jul 6;32(3):155-172
references.pmid: 10837642
references.citation: Int J Pharm. 2008 Dec 8;364(2):272-80
references.pmid: 18555624
references.citation: J Immunol. 1996 Apr 15;156(8):2809-18
references.pmid: 8609400
references.citation: Hum Vaccin. 2006 Jan-Feb;2(1):1-7
references.pmid: 17012895
references.citation: Vaccine. 2002 May 31;20 Suppl 3:S24-33
references.pmid: 12184361
references.citation: J Lipid Res. 1999 Aug;40(8):1495-500
references.pmid: 10428986
references.citation: J Chromatogr A. 2003 Jul 4;1004(1-2):81-90
references.pmid: 12929964
references.citation: Methods. 1999 Sep;19(1):156-62
references.pmid: 10525452
references.citation: Biochim Biophys Acta. 1977 Oct 17;470(2):185-201
references.pmid: 911827
references.citation: Nano Lett. 2005 Feb;5(2):281-5
references.pmid: 15794611
references.citation: Curr Med Chem. 2003 Nov;10(22):2425-46
references.pmid: 14529483
references.citation: J Nanosci Nanotechnol. 2009 Jun;9(6):3578-86
references.pmid: 19504885
references.citation: Biochim Biophys Acta. 2004 May 27;1663(1-2):135-42
references.pmid: 15157616
references.citation: Langmuir. 2005 Oct 25;21(22):10160-4
references.pmid: 16229540
references.citation: Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4942-6
references.pmid: 8506338
references.citation: J Antimicrob Chemother. 2005 May;55(5):727-34
references.pmid: 15761070
references.citation: J Immunol. 1974 Apr;112(4):1526-34
references.pmid: 4815095
references.citation: Biochim Biophys Acta. 1976 Sep 7;443(3):313-30
references.pmid: 963059
references.citation: J Colloid Interface Sci. 2007 Sep 15;313(2):519-26
references.pmid: 17532328
references.citation: Langmuir. 2005 Oct 11;21(21):9495-501
references.pmid: 16207027
references.citation: J Colloid Interface Sci. 2006 Jan 1;293(1):240-7
references.pmid: 16095603
references.citation: Int J Pharm. 2005 Jul 25;298(2):315-22
references.pmid: 15961266