title: Multimodality management of a locally advanced primary oesophageal melanoma with radical surgery and adjuvant chemoimmunoradiotherapy.
abstract: We present the case of a 46-year-old woman diagnosed with a primary oesophageal melanoma (PEM), who was treated with radical surgery followed by combined chemoimmunotherapy (interferon, carboplatin, dacarbazine and external radiotherapy) and who achieved a complete response after this treatment. PEMs are rare malignancies, with less than 300 cases described in the literature. The main differential diagnosis is with metastases of skin or ocular malignant melanomas. They are usually diagnosed at advanced stages and prognosis is typically poor. The main treatment modality should be radical surgery. The role of adjuvant treatment is uncertain, although some long responses have been seen with the use of chemotherapy or immunotherapy alongside surgery.
authors.affiliation: Medical Oncology Unit, University Hospital La Fe, Valencia, Spain. diaz_rob@gva.es
authors.forename: R
authors.initials: R
authors.lastname: Díaz
authors.forename: P
authors.initials: P
authors.lastname: Moral
authors.forename: M
authors.initials: M
authors.lastname: Fonfría
authors.forename: M
authors.initials: M
authors.lastname: de Juan
authors.forename: N
authors.initials: N
authors.lastname: Mancheño
authors.forename: A
authors.initials: A
authors.lastname: Tormo
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007167:Immunotherapy / Q000379:methods; D007372:Interferons / Q000008:administration & dosage; D008545:Melanoma / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D003606:Dacarbazine; D007372:Interferons; D016190:Carboplatin
references.citation: Melanoma Res. 2007 Aug;17(4):239-42
references.pmid: 17625454
references.citation: Surgery. 2006 Jul;140(1):118-9
references.pmid: 16857450
references.citation: Ann Thorac Surg. 1997 May;63(5):1461-3
references.pmid: 9146346
references.citation: Arch Pathol Lab Med. 2008 Oct;132(10):1675-8
references.pmid: 18834229
references.citation: Radiology. 1998 Nov;209(2):455-9
references.pmid: 9807573
references.citation: Onkologie. 2007 Apr;30(4):206-8
references.pmid: 17396044
references.citation: Ann Thorac Surg. 1995 Jul;60(1):217-22
references.pmid: 7598604
references.citation: Ann Surg Oncol. 2006 Apr;13(4):525-32
references.pmid: 16474909
references.citation: Radiology. 1999 Oct;213(1):97-100
references.pmid: 10540647
references.citation: Br J Surg. 2002 Apr;89(4):389-96
references.pmid: 11952577
references.citation: Nat Clin Pract Gastroenterol Hepatol. 2007 Mar;4(3):171-4
references.pmid: 17339854
references.citation: Acta Gastroenterol Belg. 2006 Jan-Mar;69(1):12-4
references.pmid: 16673556
references.citation: Pathol Int. 2008 Jul;58(7):432-5
references.pmid: 18577112
references.citation: Dis Esophagus. 2000;13(4):320-3
references.pmid: 11284983
references.citation: Dig Dis Sci. 2004 Oct;49(10):1646-51
references.pmid: 15573920
references.citation: Arch Pathol Lab Med. 2006 Apr;130(4):552-7
references.pmid: 16594751
references.citation: Dis Esophagus. 2002;15(3):244-9
references.pmid: 12444999
references.citation: Dis Esophagus. 2001;14(3-4):241-4
references.pmid: 11869329
references.citation: Gastrointest Endosc. 2007 Aug;66(2):408-10
references.pmid: 17643724
references.citation: Int J Clin Oncol. 2005 Jun;10(3):204-7
references.pmid: 15990972