title: Effects of a 6-days-a-week low protein diet regimen on depressive symptoms in young-old type 2 diabetic patients.
abstract: OBJECTIVE
  Late-life depression is one of the main health problems among elderly diabetic subjects. In addition, depression is a common psychopathological condition among renal failure patients and most of these patients follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear.
  
  
  METHODS
  In the present study, the effects of LPD regimen on depressive symptoms in elderly type 2 diabetic subjects with renal failure were investigated.
  
  
  METHODS
  Fifty-two young-old type 2 diabetic patients with renal failure were enrolled in the study. All participants after normal protein diet regimen providing 1.2g/kg per d were instructed to consume either a LPD providing 0.8 g/kg per d, 7 d a wk (LPD 7/7), or a LPD providing 0.8 g/kg per d 6 d a wk (LPD 6/7) randomly.
  
  
  RESULTS
  Mean 15-item Geriatric Depression Scale (GDS-15) (2.0±0.6) and Beck Depression Inventory (BDI) (4.1±1.0), during normal protein diet regimen, significantly increased to (6.7±1.6) and (12.2±1.4), respectively, after LPD 7/7 (P<0.05 versus normal protein diet). However, after LPD 6/7, mean GDS-15 and BDI significantly decreased to (4.4±1.5) and (6.7±1.6), respectively (P<0.05 versus LPD 7/7).
  
  
  CONCLUSIONS
  LPD 6/7 regimen significantly decreased depressive symptoms in young-old type 2 diabetic patients.
authors.affiliation: Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Ciarambino
authors.affiliation: Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Ferrara
authors.affiliation: Department of Internal Medicine, University of Catania, Catania, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Castellino
authors.affiliation: Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.affiliation: Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Coppola
authors.affiliation: Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy. Electronic address: mauro.giordano@unina2.it.
authors.forename: Mauro
authors.initials: M
authors.lastname: Giordano
mesh_terms: D000368:Aged; D003863:Depression / Q000178:diet therapy* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000523:psychology*; D003928:Diabetic Nephropathies / Q000178:diet therapy / Q000523:psychology; D018753:Diet, Protein-Restricted; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000178:diet therapy / Q000209:etiology; D012720:Severity of Illness Index
chemical_list: D004044:Dietary Proteins