title: Prostate cancer diagnosis.
abstract: Prostate cancer is the fourth most common malignancy diagnosed in Missouri. The diagnosis may be clinically suspected based on an elevated serum prostate specific antigen (PSA) and/or digital rectal examination abnormality. Clinical symptoms are usually a manifestation of more advanced disease. The diagnosis is typically established by histopathologic examination of needle biopsy tissue. This article reviews clinical and pathological approaches to prostate cancer diagnosis, with a focus on clinically localized disease and needle biopsy diagnosis.
authors.affiliation: Washington University School of Medicine in St. Louis, USA. humphrey@path.wustl.edu
authors.forename: Peter A
authors.initials: PA
authors.lastname: Humphrey
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Andriole
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D051517:Digital Rectal Examination; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010338:Pathology, Clinical / Q000379:methods; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen
references.citation: J Urol. 1998 Dec;160(6 Pt 2):2407-11
references.pmid: 9817393
references.citation: N Engl J Med. 2009 Mar 26;360(13):1310-9
references.pmid: 19297565
references.citation: N Engl J Med. 2009 Mar 26;360(13):1320-8
references.pmid: 19297566
references.citation: N Engl J Med. 2004 May 27;350(22):2239-46
references.pmid: 15163773
references.citation: J Natl Cancer Inst. 2006 May 17;98(10):715-7
references.pmid: 16705126
references.citation: J Urol. 2006 Mar;175(3 Pt 1):820-34
references.pmid: 16469560
references.citation: JAMA. 1994 Feb 2;271(5):368-74
references.pmid: 7506797
references.citation: J Clin Pathol. 2007 Jan;60(1):35-42
references.pmid: 17213347
references.citation: Nat Rev Cancer. 2008 Apr;8(4):268-78
references.pmid: 18337732
references.citation: N Engl J Med. 2004 Jul 8;351(2):125-35
references.pmid: 15247353
references.citation: JAMA. 2007 Oct 3;298(13):1533-8
references.pmid: 17911498
references.citation: BJU Int. 2008 Dec;102(11):1524-30
references.pmid: 19035857
references.citation: Cancer. 2008 Apr 15;112(8):1650-9
references.pmid: 18306379
references.citation: BJU Int. 2008 Aug 5;102(5):546-50
references.pmid: 18694408
references.citation: J Urol. 2007 Dec;178(6):2359-64; discussion 2364-5
references.pmid: 17936806
references.citation: Cancer. 2008 Dec 1;113(11):3075-99
references.pmid: 18823041
references.citation: Cancer. 2004 Sep 1;101(5):894-904
references.pmid: 15329895
references.citation: Urology. 2007 Jun;69(6):1095-101
references.pmid: 17572194
references.citation: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
references.pmid: 18287387