title: Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii.
abstract: Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10ng/ml and 100ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.
authors.affiliation: Ranbaxy Research Labs, R&D-III, Gurgaon, Haryana, India. anil.kanaujia@ranbaxy.com
authors.forename: Anil
authors.initials: A
authors.lastname: Kanaujia
authors.forename: Rajeev
authors.initials: R
authors.lastname: Duggar
authors.forename: Steve Thomas
authors.initials: ST
authors.lastname: Pannakal
authors.forename: Satyapal Singh
authors.initials: SS
authors.lastname: Yadav
authors.forename: Chandra Kant
authors.initials: CK
authors.lastname: Katiyar
authors.forename: Vinay
authors.initials: V
authors.lastname: Bansal
authors.forename: S
authors.initials: S
authors.lastname: Anand
authors.forename: S
authors.initials: S
authors.lastname: Sujatha
authors.forename: B S
authors.initials: BS
authors.lastname: Lakshmi
mesh_terms: D000818:Animals; D031484:Capparis / Q000737:chemistry*; D002460:Cell Line; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000235:genetics; D047348:Hydrolyzable Tannins / Q000302:isolation & purification* / Q000494:pharmacology*; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D018716:Molecular Mimicry; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D010766:Phosphorylation / Q000187:drug effects; D008517:Phytotherapy; D012333:RNA, Messenger / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism
chemical_list: D051275:Glucose Transporter Type 4; D047348:Hydrolyzable Tannins; D055504:Insulin Receptor Substrate Proteins; D012333:RNA, Messenger; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D005947:Glucose