[Chronic pancreatitis as a risk factor for the development of pancreatic cancer--diagnostic challenges].
Patients with chronic pancreatitis are burdened with an increased risk of developing pancreatic cancer. Strategies or guidelines for the surveillance and early detection of pancreatic adenocarcinoma in patients with chronic pancreatitis are not established, because available clinical, serologic or imaging techniques are still of limited sensitivity and specificity. Despite these limitations do patients with chronic pancreatitis and suspected pancreatic cancer need a careful and sometimes repeated diagnostic work-up. A clear benefit of surveillance programs outside of clinical trials for the early detection of pancreatic cancer has not been demonstrated. A 51-year-old patient with chronic pancreatitis is reported who developed cancer of the pancreatic head while undergoing repeated imaging studies.
Pickartz
Tilman
T
Klinik und Poliklinik für Innere Medizin A, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany.
Mayerle
Julia
J
Kraft
Matthias
M
Evert
Matthias
M
Evert
Katja
K
Kühn
Jens-Peter
JP
Heidecke
Claus-Dieter
CD
Lerch
Markus M
MM
D000713:Anastomosis, Roux-en-Y; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D042241:Early Diagnosis; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D019512:Pancreatitis, Alcoholic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
Med Clin North Am. 2000 May;84(3):531-47, vii
10872412
J Natl Cancer Inst. 1994 Apr 20;86(8):625-7
8145277
Clin Gastroenterol Hepatol. 2004 Mar;2(3):252-61
15017610
Nat Clin Pract Gastroenterol Hepatol. 2007 Jun;4(6):314-23
17541445
Gastrointest Endosc. 2002 Jul;56(1):66-71
12085037
Lancet Oncol. 2009 Jan;10(1):88-95
19111249
Pancreas. 2003 Nov;27(4):321-6
14576495
N Engl J Med. 1993 May 20;328(20):1433-7
8479461
Nat Genet. 1996 Oct;14(2):141-5
8841182
Gastrointest Endosc. 1998 Jul;48(1):11-7
9684658
Gut. 2009 Oct;58(10):1410-8
19470496
Pancreatology. 2001;1(5):405-15
12120217
Curr Gastroenterol Rep. 2004 Apr;6(2):104-10
15191687
J Eval Clin Pract. 2009 Feb;15(1):62-8
19239583
Am J Gastroenterol. 2008 Jan;103(1):111-9
18184119
Int J Pancreatol. 2000 Apr;27(2):93-103
10862508
Pancreas. 2009 Nov;38(8):846-8
19855232
J Biol Chem. 2002 Feb 15;277(7):5404-10
11719509
Clin Gastroenterol Hepatol. 2006 Jun;4(6):766-81; quiz 665
16682259
Am J Gastroenterol. 1990 Oct;85(10):1427-8
2220745
Surgery. 1997 Jul;122(1):53-9
9225915
JAMA. 2001 Jul 11;286(2):169-70
11448279
Chirurg. 2004 Jul;75(7):731-47; quiz 748
15205751
Am J Gastroenterol. 2009 Sep;104(9):2175-81
19491823
Eur J Gastroenterol Hepatol. 2004 Nov;16(12):1295-9
15618835
Am J Gastroenterol. 2004 May;99(5):844-50
15128348
Br J Surg. 1999 Feb;86(2):189-93
10100785
Am J Gastroenterol. 2004 Jul;99(7):1258-66
15233663
Int J Biochem Cell Biol. 2004 Aug;36(8):1386-92
15147717
J Natl Cancer Inst. 1997 Mar 19;89(6):442-6
9091646
Gastroenterology. 1952 May;21(1):54-63
14926813
Gut. 2007 Oct;56(10):1460-9
17872573
Clin Gastroenterol Hepatol. 2006 Aug;4(8):1010-6; quiz 934
16843735