Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease.
A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease.
Basaranoglu
Metin
M
Division of Gastroenterology, Ankara Yüksek Ihtisas Hospital, Ankara 06100, Turkey. metin_basaranoglu@yahoo.com
Kayacetin
Serra
S
Yilmaz
Nevin
N
Kayacetin
Ertugrul
E
Tarcin
Orhan
O
Sonsuz
Abdullah
A
D000818:Animals; D004195:Disease Models, Animal; D002149:Energy Intake; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D015227:Lipid Peroxidation; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species
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