Effects of short-term oral administration of trimethoprim-sulfamethoxazole on Schirmer II tear test results in clinically normal rabbits.
Fifteen New Zealand white rabbits were used in a study to determine whether oral administration of trimethoprim-sulfamethoxazole affects the rate of tear secretion in healthy rabbits. Ten rabbits received 40 mg/kg trimethoprim-sulfamethoxazole orally twice a day for 14 days; the other five rabbits were used as a control group and received a placebo during the study. The Schirmer II tear test (STT-II) was performed in both groups during administration of the drugs or placebo on the first, third, seventh and 14th days. Significant decreases in STT-II values were observed in the treatment group on the 14th day of the study in comparison with baseline values (P<0.001).
Shirani
D
D
Department of Clinical Sciences, School of Veterinary Medicine, University of Tehran, Tehran, Iran.
Selk Ghaffari
M
M
Akbarein
H
H
Haji Ali Asgari
A
A
D000284:Administration, Oral; D000818:Animals; D016022:Case-Control Studies; D004338:Drug Combinations; D007765:Lacrimal Apparatus / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits / Q000502:physiology*; D013419:Sulfamethizole / Q000494:pharmacology*; D013666:Tears / Q000187:drug effects* / Q000378:metabolism*; D014295:Trimethoprim / Q000494:pharmacology*; D000096926:Benzenesulfonamides
D004338:Drug Combinations; D013419:Sulfamethizole; D014295:Trimethoprim; C029078:trimethoprim sulfamethizole; D000096926:Benzenesulfonamides