Neopterin predicts left ventricular remodeling in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
BACKGROUND
Left ventricle remodeling (LVR) is a relatively common and unfavourable event occurring after acute myocardial infarction. A link exists between inflammation and LVR. Neopterin, a marker of inflammation and macrophage activation, is a predictor of left ventricular dysfunction in patients with coronary artery disease. We therefore sought to assess whether both neopterin and brain natriuretic peptide (BNP), a marker of LV dysfunction and patient outcome, correlate with LVR in patients with ST-segment elevation myocardial infarction (STEMI).


METHODS
We prospectively assessed 108 STEMI patients (age 64 + or - 11 years; 85% male) undergoing primary percutaneous coronary intervention (PCI) who were assessed echocardiographycally assessment was performed at 96 + or - 10h after the onset of symptoms and 12 month after STEMI. LVR was defined as >20% increase in LV end-diastolic volume at 12 months of follow-up compared to baseline. Neopterin and BNP serum concentrations were measured immediately before primary PCI.


RESULTS
At 1 year, 21 patients (19%) showed LVR and 87 (81%) had no LVR. Patients with LVR had higher levels of neopterin at study entry (7.45 + or - 1.04 vs 5.19 + or - 1.39 nmol/L; p<0.001). After adjustment for relevant confounders, neopterin levels were found to be an independent predictor of LVR (OR ranging from [3.10, CI 95% 1.928-4.990, p<0.001] to [3.32, CI 95% 1.999-5.532, p<0.001]). ROC analysis showed an area under the curve of 0.901 for neopterin (CI 95% 0.84-0.96, p<0.0001) compared to 0.579 for BNP (CI 95% 0.409-0.748) regarding LVR.


CONCLUSIONS
In STEMI patients undergoing primary PCI, high neopterin levels - but not BNP - predict LVR at 1-year follow-up.
Dominguez-Rodriguez
Alberto
A
Hospital Universitario de Canarias, Department of Cardiology, Tenerife, Spain. adrvdg@hotmail.com
Abreu-Gonzalez
Pedro
P
Avanzas
Pablo
P
Laynez-Cerdeña
Ignacio
I
Kaski
Juan Carlos
JC
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000628:therapy*; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis; D019798:Neopterin / Q000096:biosynthesis*; D012372:ROC Curve; D012044:Regression Analysis; D012307:Risk Factors; D020257:Ventricular Remodeling / Q000187:drug effects*
D020097:Natriuretic Peptide, Brain; D019798:Neopterin