title: Outcomes of critically ill patients with cirrhosis admitted to intensive care: an important perspective from the non-transplant setting.
abstract: BACKGROUND
  Hospital admissions for cirrhosis have been increasing in the United Kingdom, leading to increased pressure on intensive care (ICU) services. Outcome data for patients admitted to ICU are currently limited to transplant centre reports, with mortality rates exceeding 70%. These tertiary reports could fuel a negative bias when patients with cirrhosis are reviewed for ICU admission in secondary care.
  
  
  OBJECTIVE
  To determine whether disease severity and mortality rates in non-transplant general ICU are less severe than those reported by tertiary datasets.
  
  
  METHODS
  A prospective dual-centre non-transplant ICU study. Admissions were screened for cirrhosis and physiological and biochemical data were collected. Disease-specific and critical illness scoring systems were evaluated.
  
  
  RESULTS
  Cirrhosis was present in 137/4198 (3.3%) of ICU admissions. ICU and hospital mortality were 38% and 47%, respectively; median age 50 [43-59] years, 68% men, 72% alcoholic cirrhosis, median Child Pugh Score (CPS) 10 [8-11], Model for End-Stage Liver Disease (MELD) 18 [12-24], Acute Physiology and Chronic Health Evaluation II score (APACHE II) 16 [13-22].
  
  
  CONCLUSIONS
  Mortality rates and disease staging were notably lower than in the published literature, suggesting that patients have a more favourable outlook than previously considered. Transplant centre data should therefore be interpreted with caution when evaluating the merits of intensive care admission for patients in general secondary care ICUs.
authors.affiliation: Department of Hepatology, St George's Hospital, Tooting, London, UK. samjthomson@gmail.com
authors.forename: S J
authors.initials: SJ
authors.lastname: Thomson
authors.forename: C
authors.initials: C
authors.lastname: Moran
authors.forename: M L
authors.initials: ML
authors.lastname: Cowan
authors.forename: S
authors.initials: S
authors.lastname: Musa
authors.forename: R
authors.initials: R
authors.lastname: Beale
authors.forename: D
authors.initials: D
authors.lastname: Treacher
authors.forename: M
authors.initials: M
authors.lastname: Hamilton
authors.forename: R M
authors.initials: RM
authors.lastname: Grounds
authors.forename: T M
authors.initials: TM
authors.lastname: Rahman
mesh_terms: D018806:APACHE; D003422:Critical Care / Q000706:statistics & numerical data*; D016638:Critical Illness; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008103:Liver Cirrhosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality*; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology