[Substantiation of possibility of use GABA-receptor's chloride channel blockers for modelling of the temporal epilepsy].
In work the review of some clinik-morphological and pharmacological researches devoted to a temporal epilepsy and its experimental models is resulted. On the basis of the analysis of existing problems in working out antiepileptic drugs and in studying of mechanisms epilepsy necessity of development of new chronic experimental models of a temporal epilepsy is proved. The basic criteria of experimental model of a temporal epilepsy are generalised. It is shown that parametres of acute toxicity and the remote consequences of an intoxication convulsive agents from group GABA-receptor's chloride channel blockers correspond to the basic criteria a post-epistatus of model of a temporal epilepsy. The conclusion is presented on use possibility GABA-receptor's chloride channel blockers in quality agents for modelling of a temporal epilepsy.
Bragina
T A
TA
Ivanov
I M
IM
Golovko
A I
AI
Ivanov
M B
MB
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000302:isolation & purification; D001952:Bridged-Ring Compounds / Q000008:administration & dosage; D018118:Chloride Channels / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D055808:Drug Discovery; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced* / Q000503:physiopathology*; D018756:GABA Antagonists / Q000008:administration & dosage*; D006801:Humans; D007696:Kindling, Neurologic / Q000187:drug effects; D009636:Norbornanes / Q000008:administration & dosage
D000927:Anticonvulsants; D001952:Bridged-Ring Compounds; D018118:Chloride Channels; D018756:GABA Antagonists; D009636:Norbornanes; C010349:tetramethylenedisulfotetramine