The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss.
The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.
Wolff
Amy R
AR
Psychology Department, University of Otago, Dunedin, New Zealand.
Bilkey
David K
DK
D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011070:Poly I-C; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology / Q000523:psychology*; D051381:Rats; D012559:Schizophrenia / Q000276:immunology* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D055139:Sensory Gating / Q000502:physiology*; D015431:Weight Loss
D011070:Poly I-C