title: Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging.
abstract: The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), performed (11)C-Pittsburgh Compound B (PiB) scans in 177 healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients. High PiB binding was present in 33% of HC (49% in ApoE-epsilon4 carriers vs 21% in noncarriers) and increased with age, most strongly in epsilon4 carriers. 18% of HC aged 60-69 had high PiB binding rising to 65% in those over 80 years. Subjective memory complaint was only associated with elevated PiB binding in epsilon4 carriers. There was no correlation with cognition in HC or MCI. PiB binding in AD was unrelated to age, hippocampal volume or memory. Beta-amyloid (Abeta) deposition seems almost inevitable with advanced age, amyloid burden is similar at all ages in AD, and secondary factors or downstream events appear to play a more direct role than total beta amyloid burden in hippocampal atrophy and cognitive decline.
authors.affiliation: Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia. Christopher.Rowe@austin.org.au
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Rowe
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Ellis
authors.forename: Miroslava
authors.initials: M
authors.lastname: Rimajova
authors.forename: Pierrick
authors.initials: P
authors.lastname: Bourgeat
authors.forename: Kerryn E
authors.initials: KE
authors.lastname: Pike
authors.forename: Gareth
authors.initials: G
authors.lastname: Jones
authors.forename: Jurgen
authors.initials: J
authors.lastname: Fripp
authors.forename: Henri
authors.initials: H
authors.lastname: Tochon-Danguy
authors.forename: Laurence
authors.initials: L
authors.lastname: Morandeau
authors.forename: Graeme
authors.initials: G
authors.lastname: O'Keefe
authors.forename: Roger
authors.initials: R
authors.lastname: Price
authors.forename: Parnesh
authors.initials: P
authors.lastname: Raniga
authors.forename: Peter
authors.initials: P
authors.lastname: Robins
authors.forename: Oscar
authors.initials: O
authors.lastname: Acosta
authors.forename: Nat
authors.initials: N
authors.lastname: Lenzo
authors.forename: Cassandra
authors.initials: C
authors.lastname: Szoeke
authors.forename: Olivier
authors.initials: O
authors.lastname: Salvado
authors.forename: Richard
authors.initials: R
authors.lastname: Head
authors.forename: Ralph
authors.initials: R
authors.lastname: Martins
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D001315:Australia / Q000453:epidemiology; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D017352:Echo-Planar Imaging; D005260:Female; D006580:Genetic Carrier Screening; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011446:Prospective Studies; D040242:Risk Reduction Behavior; D013844:Thiazoles / Q000378:metabolism
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D015415:Biomarkers; D013844:Thiazoles