title: Regulation of signal transduction by integrins.
abstract: The integrin family of cell membrane receptors plays an important role in signal transduction cascades. Ligation of integrins by extracellular matrix proteins can lead to direct activation of Rho-family GTPases and MAP kinase pathways. However, perhaps the most significant signaling function of integrins is to modulate signal transduction events initiated by receptor tyrosine kinases and G protein-coupled receptors. This probably plays a role in coordinating information about cell shape and position with information about the availability of soluble growth factors.
authors.affiliation: Department of Pharmacology, University of North Carolina, CB 7365, Chapel Hill, NC, 27599-7365, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: P
authors.initials: P
authors.lastname: Reddig
authors.forename: R L
authors.initials: RL
authors.lastname: Juliano