title: Anti-mullerian hormone and cumulative pregnancy outcome in in-vitro fertilization.
abstract: OBJECTIVE
  To evaluate the role of Anti-mullerian hormone (AMH) in predicting cumulative pregnancy outcome during in-vitro fertilization (IVF) treatment.
  
  
  METHODS
  Serum AMH levels on day 6 of ovarian stimulation were taken from 180 women undergoing IVF with or without intracytoplasmic sperm injection (ICSI). The main outcome measures were ongoing pregnancy in the fresh cycle, cumulative ongoing pregnancy and ovarian response.
  
  
  RESULTS
  There was a trend of higher median AMH levels in subjects achieving ongoing pregnancy in the fresh IVF cycle. The median AMH levels were significantly higher in subjects attaining ongoing pregnancy cumulatively and in subjects showing ovarian hyper-response in the stimulated cycle. Areas under the ROC curves were 0.606 and 0.792 for the prediction of cumulative ongoing pregnancy and ovarian hyper-response respectively.
  
  
  CONCLUSIONS
  Serum AMH concentration on day 6 of stimulation was significantly higher in subjects who achieved cumulative ongoing pregnancy in IVF compared to those who did not. Serum AMH is a reasonably good predictor of ovarian hyper-response.
authors.affiliation: Assisted Conception Programme, Royal Infirmary of Edinburgh, Edinburgh, UK. suresh.kini@nhs.net
authors.forename: Suresh
authors.initials: S
authors.lastname: Kini
authors.forename: H W Raymond
authors.initials: HW
authors.lastname: Li
authors.forename: Dave
authors.initials: D
authors.lastname: Morrell
authors.forename: Sue
authors.initials: S
authors.lastname: Pickering
authors.forename: K Joo
authors.initials: KJ
authors.lastname: Thong
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
chemical_list: D054304:Anti-Mullerian Hormone
references.citation: Fertil Steril. 2006 Mar;85(3):592-6
references.pmid: 16500324
references.citation: Hum Reprod. 2006 Aug;21(8):2022-6
references.pmid: 16679324
references.citation: Curr Opin Obstet Gynecol. 2008 Jun;20(3):257-64
references.pmid: 18460940
references.citation: Hum Reprod. 2004 Nov;19(11):2439-41
references.pmid: 15319392
references.citation: Clin Endocrinol (Oxf). 2006 Jun;64(6):603-10
references.pmid: 16712660
references.citation: Fertil Steril. 2004 Nov;82(5):1323-9
references.pmid: 15533354
references.citation: Fertil Steril. 2009 Mar;91(3):705-14
references.pmid: 18321493
references.citation: Hum Reprod. 1997 Jul;12(7):1545-9
references.pmid: 9262293
references.citation: Br J Obstet Gynaecol. 1998 Jan;105(1):107-12
references.pmid: 9442172
references.citation: Hum Reprod. 2003 May;18(5):1062-9
references.pmid: 12721185
references.citation: Hum Reprod. 2009 Sep;24(9):2264-75
references.pmid: 19520713
references.citation: Reprod Biomed Online. 2008 May;16(5):664-70
references.pmid: 18492370
references.citation: Fertil Steril. 2009 Jul;92(1):395.e9-395.e12
references.pmid: 19410249
references.citation: Hum Reprod. 2005 Apr;20(4):915-22
references.pmid: 15665015
references.citation: Ann N Y Acad Sci. 2008 Apr;1127:49-58
references.pmid: 18443329
references.citation: Reprod Biomed Online. 2007 May;14(5):602-10
references.pmid: 17509203
references.citation: Fertil Steril. 2009 Jun;91(6):2616-9
references.pmid: 18555223
references.citation: Hum Reprod. 2007 Jul;22(7):1837-40
references.pmid: 17485437
references.citation: Hum Reprod. 2009 Apr;24(4):867-75
references.pmid: 19136673
references.citation: Br J Obstet Gynaecol. 1994 Nov;101(11):999-1002
references.pmid: 7999732
references.citation: Fertil Steril. 2009 Jan;91(1):226-30
references.pmid: 18249391
references.citation: Hum Reprod. 2003 Feb;18(2):328-32
references.pmid: 12571169
references.citation: Fertil Steril. 2008 Sep;90(3):737-43
references.pmid: 17923131
references.citation: Hum Reprod Update. 2006 Nov-Dec;12(6):685-718
references.pmid: 16891297
references.citation: J Clin Endocrinol Metab. 2006 Oct;91(10):4057-63
references.pmid: 16804046
references.citation: Eur J Obstet Gynecol Reprod Biol. 2004 Jul 1;115 Suppl 1:S106-9
references.pmid: 15196727
references.citation: J Assist Reprod Genet. 2001 Mar;18(3):151-5
references.pmid: 11411430
references.citation: Hum Reprod. 2006 Dec;21(12):3103-7
references.pmid: 16923748
references.citation: Hum Reprod. 2000 Sep;15(9):1937-42
references.pmid: 10966990
references.citation: Fertil Steril. 2007 Jan;87(1):223-6
references.pmid: 17081531
references.citation: Fertil Steril. 2008 Apr;89(4):927-33
references.pmid: 17603052
references.citation: Mol Hum Reprod. 2004 Feb;10(2):77-83
references.pmid: 14742691
references.citation: J Clin Endocrinol Metab. 1996 Feb;81(2):571-6
references.pmid: 8636269
references.citation: Hum Reprod. 2006 Jan;21(1):159-63
references.pmid: 16123085
references.citation: Reproduction. 2006 Jan;131(1):1-9
references.pmid: 16388003
references.citation: Fertil Steril. 2009 Nov;92(5):1586-93
references.pmid: 18930213
references.citation: Hum Reprod. 2007 Sep;22(9):2414-21
references.pmid: 17636277