Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate.
We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism.
Choi
Seok Ki
SK
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Medical School, Ann Arbor, MI 48109, USA. skchoi@umich.edu
Thomas
Thommey
T
Li
Ming-Hsin
MH
Kotlyar
Alina
A
Desai
Ankur
A
Baker
James R
JR
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010782:Photolysis; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism; D014466:Ultraviolet Rays
D000903:Antibiotics, Antineoplastic; D002352:Carrier Proteins; D050091:Dendrimers; D004337:Drug Carriers; D058973:Folate Receptors, GPI-Anchored; C104700:PAMAM Starburst; D011956:Receptors, Cell Surface; D004317:Doxorubicin; D005492:Folic Acid
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