title: Silver nanosystems for photoacoustic imaging and image-guided therapy.
abstract: Due to their optical absorption properties, metallic nanoparticles are excellent photoacoustic imaging contrast agents. A silver nanosystem is presented here as a potential contrast agent for photoacoustic imaging and image-guided therapy. Currently, the nanosystem consists of a porous silver layer deposited on the surface of spherical silica cores ranging in diameter from 180 to 520 nm. The porous nature of the silver layer will allow for release of drugs or other therapeutic agents encapsulated in the core in future applications. In their current PEGylated form, the silver nanosystem is shown to be nontoxic in vitro at concentrations of silver up to 2 mgml. Furthermore, the near-infrared absorbance properties of the nanosystem are demonstrated by measuring strong, concentration-dependent photoacoustic signal from the silver nanosystem embedded in an ex vivo tissue sample. Our study suggests that silver nanosystems can be used as multifunctional agents capable of augmenting image-guided therapy techniques.
authors.affiliation: The University of Texas at Austin, Biomedical Engineering Department, 1 University Station C0800, Austin, Texas 78712, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Homan
authors.forename: Jignesh
authors.initials: J
authors.lastname: Shah
authors.forename: Sobeyda
authors.initials: S
authors.lastname: Gomez
authors.forename: Heidi
authors.initials: H
authors.lastname: Gensler
authors.forename: Andrei
authors.initials: A
authors.lastname: Karpiouk
authors.forename: Lisa
authors.initials: L
authors.lastname: Brannon-Peppas
authors.forename: Stanislav
authors.initials: S
authors.lastname: Emelianov
mesh_terms: D003287:Contrast Media; D054459:Elasticity Imaging Techniques / Q000379:methods*; D007089:Image Enhancement / Q000379:methods*; D049329:Nanostructures; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012834:Silver; D025321:Surgery, Computer-Assisted / Q000379:methods*
chemical_list: D003287:Contrast Media; D012834:Silver
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