eEF1A: thinking outside the ribosome.
Eukaryotic translation elongation factor 1A (eEF1A) is one of the most abundant protein synthesis factors. eEF1A is responsible for the delivery of all aminoacyl-tRNAs to the ribosome, aside from initiator and selenocysteine tRNAs. In addition to its roles in polypeptide chain elongation, unique cellular and viral activities have been attributed to eEF1A in eukaryotes from yeast to plants and mammals. From preliminary, speculative associations to well characterized biochemical and biological interactions, it is clear that eEF1A, of all the translation factors, has been ascribed the most functions outside of protein synthesis. A mechanistic understanding of these non-canonical functions of eEF1A will shed light on many important biological questions, including viral-host interaction, subcellular organization, and the integration of key cellular pathways.
Mateyak
Maria K
MK
Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854-5635, USA.
Kinzy
Terri Goss
TG
D000199:Actins / Q000737:chemistry; D021581:Active Transport, Cell Nucleus; D017209:Apoptosis; D003599:Cytoskeleton / Q000378:metabolism; D015977:Eukaryotic Initiation Factor-1 / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D010445:Peptide Elongation Factors; D014176:Protein Biosynthesis; D011487:Protein Conformation; D012328:RNA Viruses / Q000378:metabolism; D012343:RNA, Transfer / Q000737:chemistry*; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D017279:Selenocysteine / Q000737:chemistry*
D000199:Actins; D015977:Eukaryotic Initiation Factor-1; D010445:Peptide Elongation Factors; C026022:eukaryotic peptide initiation factor-1A; D017279:Selenocysteine; D012343:RNA, Transfer
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