Study of cross-reactivity between proton pump inhibitors.
Several studies have demonstrated different cross-reactivity patterns between proton pump inhibitors (PPIs). The aim of this study was to investigate cross-reactivity between commercially available PPIs and establish a procedure for performing cutaneous tests for verifying PPI allergy. We performed skin prick and intradermal tests with all commercially available PPIs in 5 patients with clinical allergy to omeprazole and observed positive results in all patients. We report 5 cases of immunoglobulin (Ig) E-mediated allergy to omeprazole and document cross-reactivity by skin testing between all the PPIs studied. We also found that the probability of confirming an IgE-mediated mechanism with skin tests decreases with time. Finally, we propose a hypothesis that could explain the different PPI cross-reactivity patterns reported.
Sobrevia Elfau
M T
MT
Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain. materesas@hotmail.com
Garcés Sotillos
M
M
Ferrer Clavería
L
L
Segura Arazuri
N
N
Monzón Ballarin
S
S
Colás Sanz
C
C
D000328:Adult; D000799:Angioedema; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D009853:Omeprazole / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D012882:Skin Tests; D014581:Urticaria
D054328:Proton Pump Inhibitors; D009853:Omeprazole