Axon guidance: repulsion and attraction in roundabout ways.
The secreted signal Slit and its three receptors, Robo1-3, regulate axon guidance in the Drosophila nervous system. Differences in expression and structure of Robo paralogs contribute to diversifying growth cone responses to a common ligand.
Pappu
Kartik S
KS
Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zipursky
S Lawrence
SL
D000818:Animals; D001369:Axons / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development*; D005796:Genes / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009420:Nervous System / Q000254:growth & development; D011971:Receptors, Immunologic / Q000502:physiology; D000097905:Roundabout Proteins
D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins