title: Comparison of endoscopy, histology, and cytokine mRNA of the equine gastric mucosa.
abstract: In recent years, gastric ulceration has been recognized as a common, possibly performance-limiting disease, of adult horses. The aim of this study was to compare endoscopic features, histological diagnosis, and mRNA levels of various cytokines (TNF-alpha, IL-1beta, and IL-13) from horse gastric biopsies. Eleven horses suffering from equine gastric ulcer syndrome and seven horses with normal histological gastric features were assessed. No correlation between endoscopic features and histology (i.e., the gold standard) was observed. Based on histological diagnosis, a significant (p < 0.05) increase in cytokine mRNA levels (specifically, TNF-alpha and IL-13) was observed in horses affected by equine ulcerative gastric syndrome.
authors.affiliation: Department of Veterinary Clinical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy. marco.pietra@unibo.it
authors.forename: M
authors.initials: M
authors.lastname: Pietra
authors.forename: M
authors.initials: M
authors.lastname: Morini
authors.forename: G
authors.initials: G
authors.lastname: Perfetti
authors.forename: A
authors.initials: A
authors.lastname: Spadari
authors.forename: P
authors.initials: P
authors.lastname: Vigo
authors.forename: A
authors.initials: A
authors.lastname: Peli
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D016099:Endoscopy, Gastrointestinal / Q000662:veterinary*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation / Q000502:physiology; D006734:Horse Diseases / Q000378:metabolism / Q000473:pathology*; D006736:Horses; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D016207:Cytokines; D012333:RNA, Messenger
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