The use of click chemistry in the emerging field of catalomics.
Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.
Kalesh
Karunakaran A
KA
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore117543.
Shi
Haibin
H
Ge
Jingyan
J
Yao
Shao Q
SQ
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods* / Q000639:trends
D004791:Enzyme Inhibitors; D004798:Enzymes