The sympathetic-vagal balance against endotoxemia.
The goal of this study was to establish a convenient and effective approach to anti-inflammation treatment by rebalancing the sympathetic-vagal system via vagal nerve stimulation (VNS). We established an endotoxemia model in Sprague-Dawley rats using lipopolysaccharide (LPS) injection. Electrical discharges in the vagal system, including the nucleus tractus solitarii (NTS) and afferent and efferent cervical vagal nerves, were detected. The condition of sympathetic-vagal balance, presented as heart rate variability (HRV) and hepatic norepinephrine/acetylcholine (NE/ACh), was measured following endotoxemia with and without VNS. Discharges in afferent and efferent vagal nerves increased significantly following LPS injection compared with the basis level and corresponding time points in the control group. Discharges in the NTS also increased significantly following LPS injection. The HRV components, including normalized high frequency (HFnm), normalized low frequency (LFnm), LF/HF, and very low frequency (VLF), increased significantly following LPS injection. HFnm values in the LPS + VNS group increased significantly compared with the LPS group. Conversely, LFnm, LF/HF, and VLF in the LPS + VNS group decreased significantly compared with the LPS group. Hepatic NE and ACh significantly decreased within 6 h after LPS injection compared with the basal level and the control groups (P < 0.05). VNS did not significantly improve hepatic NE, but the ACh levels in the LPS + VNS group were higher than those in other groups. Sympathetic and vagal nervous systems are enhanced following endotoxemia. The overexcitation of the sympathetic system leads to sympathetic-vagal disequilibrium. The rebalance of the sympathetic and vagal system is crucial for critically ill patients.
Huang
Jian
J
Intensive Care Unit, Trauma center of PLA, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China. huajcn@yahoo.com.cn
Wang
Yaoli
Y
Jiang
Dongbo
D
Zhou
Jian
J
Huang
Xiankai
X
D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000187:drug effects / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors; D014630:Vagus Nerve / Q000503:physiopathology*; D055536:Vagus Nerve Stimulation
D008070:Lipopolysaccharides; D000109:Acetylcholine; D009638:Norepinephrine
Circulation. 1997 Mar 18;95(6):1441-8
9118511
Biochim Biophys Acta. 2001 Jul 27;1537(1):49-57
11476962
J Immunol. 1994 Mar 15;152(6):3024-31
8144901
Neurosci Lett. 2005 Sep 2;385(1):64-9
15951110
Crit Care Med. 2001 Jul;29(7):1380-5
11445691
J Infect Dis. 2005 Jun 15;191(12):2138-48
15898001
Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R927-31
14557228
Rom J Intern Med. 2007;45(2):171-5
18333371
Ann Surg. 2004 Sep;240(3):547-54; discussion 554-6
15319726
J Immunol. 1994 Nov 1;153(9):4159-68
7930619
Brain Res. 1995 Mar 20;674(2):307-13
7796111
J Neuroimmunol. 1996 Jan;64(1):83-90
8598393
J Auton Nerv Syst. 1992 Apr;38(1):45-55
1588004
Nat Immunol. 2004 Jun;5(6):575-81
15164017
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11008-13
18669662
Gut. 2008 Jul;57(7):911-21
18308830
Neuropsychopharmacology. 2001 Nov;25(5):713-28
11682255
Am J Respir Crit Care Med. 1999 Aug;160(2):458-65
10430714
Zhonghua Shao Shang Za Zhi. 2008 Apr;24(2):99-101
18785407
J Exp Med. 2002 Mar 18;195(6):F25-8
11901206
Crit Care Med. 2002 Jan;30(1 Suppl):S58-63
11782562
Nature. 2001 Mar 22;410(6827):430-1
11260702
Diabetes Res Clin Pract. 2002 Jun;56(3):173-80
11947964
J Antimicrob Chemother. 2007 Feb;59(2):219-23
17114176
Crit Care Med. 2007 Apr;35(4):1139-44
17334244