title: Severe amiodarone-induced hypothyroidism in an infant.
abstract: OBJECTIVE
  To report a case of postnatal, postoperative amiodarone-induced hypothyroidism in an infant with a congenital heart defect.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  Pediatric intensive care unit at a freestanding tertiary care children's hospital.
  
  
  METHODS
  At 7 wks of age, a female infant with a congenital heart defect was confirmed to have profound hypothyroidism after amiodarone administration for a postoperative cardiac arrhythmia.
  
  
  METHODS
  Levothyroxine treatment.
  
  
  RESULTS
  Thyroid function tests were regularly performed to guide levothyroxine dosing. Thyroid hormone replacement was discontinued after the infant had been off amiodarone for 6 mos.
  
  
  CONCLUSIONS
  Given the potential adverse developmental consequences associated with hypothyroidism during infancy and early childhood, thyroid function tests should be carefully monitored in any infant treated with amiodarone.
authors.affiliation: Division of Cardiology, University of British Columbia and British Columbia Children's Hospital, Vancouver, BC, Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Trudel
authors.forename: Shubhayan
authors.initials: S
authors.lastname: Sanatani
authors.forename: Constadina
authors.initials: C
authors.lastname: Panagiotopoulos
mesh_terms: D000638:Amiodarone / Q000009:adverse effects*; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007223:Infant; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D000638:Amiodarone; D013974:Thyroxine