title: Randomized controlled trial of hyaluronic acid/carboxymethylcellulose dressing after endoscopic sinus surgery.
abstract: OBJECTIVE
  To determine if a hyaluronic acid/carboxymethylcellulose (HA/CMC) sinus dressing reduces the rate of postoperative scarring.
  
  
  METHODS
  In a randomized, matched-controlled, single-blinded study, following the completion of surgery, an HA/CMC dressing was randomly assigned to one side with the opposite unpacked side serving as a control.
  
  
  RESULTS
  Fifty-three patients underwent surgery for chronic rhinosinusitis (CRS; 39 patients) or CRS with nasal polyposis (14 patients). At the 8-week follow-up, there was no difference in synechiae on the HA/CMC side compared to the control (p = 0.09). HA/CMC-treated sinuses, however, demonstrated fewer synechiae in the first 2 weeks postoperatively compared to the control (p = 0.01), and were associated with significantly less nasal congestion at the 4-week (p = 0.02) and 8-week follow-up visits (0.03).
  
  
  CONCLUSIONS
  There was no long-term difference in the rate of synechiae in the HA/CMC-treated sinus compared to the control. However, less severe nasal congestion and synechiae in the initial postoperative period may reduce the need for aggressive sinus debridement.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Medical University of South Carolina Hospital, Charleston, SC 29425, USA.
authors.forename: Bradford A
authors.initials: BA
authors.lastname: Woodworth
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Chandra
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Hoy
authors.forename: Fu-Shing
authors.initials: FS
authors.lastname: Lee
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Schlosser
authors.forename: M Boyd
authors.initials: MB
authors.lastname: Gillespie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D002480:Cellulase / Q000627:therapeutic use*; D002908:Chronic Disease; D003646:Debridement; D004724:Endoscopy; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012852:Sinusitis / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006820:Hyaluronic Acid; D002480:Cellulase; C019826:carboxymethylcellulase