title: Soft-tissue sarcomas in the inguinal region may present as deep vein thrombosis.
abstract: Swelling, pain, and discoloration in the affected extremities are classic symptoms of deep vein thrombosis (DVT), although these symptoms are often unreliable for diagnosis, and wide differential diagnoses exist. Soft-tissue sarcomas arising in the inguinal region may encompass or be adjacent to femoral vessels and result in venous obstruction, mimicking symptoms of DVT. We present two cases of soft-tissue sarcomas in the inguinal region that were initially misdiagnosed as spontaneous DVT and administered unnecessary long-term anticoagulation therapy. In patients diagnosed with unprovoked DVT, especially young patients aged <45 years, we recommend a careful physical examination and ultrasonography in the inguinal region to prevent overlooking possible underlying malignancy, as delays in diagnosis may affect prognosis.
authors.affiliation: Musculoskeletal Oncology Service, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. emrmkt@yahoo.co.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Emori
authors.forename: Norifumi
authors.initials: N
authors.lastname: Naka
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Hamada
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takami
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Araki
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D019917:Blood Vessel Prosthesis Implantation; D017024:Chemotherapy, Adjuvant; D003251:Constriction, Pathologic; D003951:Diagnostic Errors; D004487:Edema / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D035002:Lower Extremity / Q000098:blood supply*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008297:Male; D020360:Neoadjuvant Therapy; D013584:Sarcoma, Synovial / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex; D019564:Unnecessary Procedures; D014652:Vascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014680:Veins / Q000473:pathology; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000925:Anticoagulants