title: Effectiveness of rotavirus vaccines for prevention of rotavirus gastroenteritis-associated hospitalizations in Israel: a case-control study.
abstract: The association between rotavirus gastroenteritis (RVGE)-associated hospitalization and rotavirus vaccine receipt was examined, and vaccine effectiveness was estimated in a case-control study conducted between 11/2007 and 12/2009 among Israeli children age eligible for rotavirus vaccination. Cases (n=111) were hospitalized children with diarrhea testing positive for rotavirus by immunochromatography. Controls (n=216) were hospitalized children with diarrhea testing negative for rotavirus. Among controls 36 (16.7%) children were vaccinated against rotavirus compared with two children (1.8%) among cases (p < 0.001). Rotavirus immunization was associated with lower risk of RVGE-associated hospitalization; adjusted OR 0.106 (95% CI 0.024, 0.481), yielding a vaccine effectiveness of 89.4% (95% CI 51.9%, 97.6%) in preventing hospitalization. These data demonstrate high effectiveness of rotavirus vaccines in a high income country.
authors.affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Khitam
authors.initials: K
authors.lastname: Muhsen
authors.forename: Lester
authors.initials: L
authors.lastname: Shulman
authors.forename: Eias
authors.initials: E
authors.lastname: Kasem
authors.forename: Uri
authors.initials: U
authors.lastname: Rubinstein
authors.forename: Jacob
authors.initials: J
authors.lastname: Shachter
authors.forename: Adi
authors.initials: A
authors.lastname: Kremer
authors.forename: Sophy
authors.initials: S
authors.lastname: Goren
authors.forename: Ilana
authors.initials: I
authors.lastname: Zilberstein
authors.forename: Gabby
authors.initials: G
authors.lastname: Chodick
authors.forename: Moshe
authors.initials: M
authors.lastname: Ephros
authors.forename: Dani
authors.initials: D
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005759:Gastroenteritis / Q000517:prevention & control* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007557:Israel; D008297:Male; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage*
chemical_list: D022243:Rotavirus Vaccines