title: Type 1 diabetes mellitus and hyperadrenocorticism in a ferret.
abstract: Diabetes mellitus (DM) was diagnosed in a 6-year-old neutered male ferret with polyuria/polydipsia, symmetrical alopecia, and weight loss. Laboratory tests revealed severe hyperglycemia, glucosuria, and increased steroid hormone profile. Abdominal ultrasound revealed a bilateral enlargement of the adrenal glands. Significant clinical improvement was achieved with insulin- and leuprolide acetate-based therapy. After 2 months of therapy, the ferret showed a severe ketoacidosis, and the owner decided to euthanize the animal. Histological findings revealed carcinoma of the left adrenal cortex and cortical hyperplasia of the right adrenal gland. Moderate, chronic, and active pancreatitis with a marked decrease in the number of beta-cells was also present. This is the first reported case of type 1 DM associated with hyperadrenocorticism and chronic pancreatitis in a ferret.
authors.affiliation: Dipartimento di Scienze Cliniche Veterinarie, Università degli Studi di Teramo, Teramo, Italy. aboari@unite.it
authors.forename: A
authors.initials: A
authors.lastname: Boari
authors.forename: V
authors.initials: V
authors.lastname: Papa
authors.forename: F
authors.initials: F
authors.lastname: Di Silverio
authors.forename: G
authors.initials: G
authors.lastname: Aste
authors.forename: D
authors.initials: D
authors.lastname: Olivero
authors.forename: F
authors.initials: F
authors.lastname: Rocconi
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000662:veterinary*; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D005289:Ferrets; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D008297:Male; D050500:Pancreatitis, Chronic / Q000662:veterinary
chemical_list: D007004:Hypoglycemic Agents; D049528:Insulin, Long-Acting
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