title: [12 years immunological effects of hepatitis B vaccine made by recombinant deoxyribonucleic acid techniques in Chinese hamster ovary cell].
abstract: OBJECTIVE
  To understand the long-term immunological effects of a recombined hepatitis B vaccine [HepB made by recombinant deoxyribonucleic acid (DNA) techniques in Chinese hamster ovary (CHO) cell, HepB (CHO)].
  
  
  METHODS
  from 1997 to 1999 all newborns in Zhengding County were administered to HepB (CHO)at birth. Children in 3 of all 7 towns in the county were selected as study objects to check their hepatitis B vaccination history and test for HBV markers.
  
  
  RESULTS
  Children who aged 10, 11 and 12 years after immunization, the anti-HBs positive rates were 71.0%, 72.1% and 68.2% respectively, and the geometric mean concentration (GMCs)were 197.9 mIU/ml, 296.0 mIU/ml and 158.0 mIU/ml respectively; Anti-HBs GMCs were 197.9 mIU/ml, 296.0 mIU/ml and 158.0 mIU/ml respectively. The Average GMC was 207.9 mIU/ml. HBsAg and anti-HBc positive rates were 0.50% and 2.26% respectively.
  
  
  CONCLUSIONS
  The long-term immunological effects of HepB (CHO) are excellent.
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, Hebei, China.
authors.forename: Shun-Xiang
authors.initials: SX
authors.lastname: Qi
authors.forename: Xin-Jiang
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D016466:CHO Cells; D002648:Child; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D005500:Follow-Up Studies; D005818:Genetic Engineering; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013997:Time Factors; D014611:Vaccination; D019444:Vaccines, DNA / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology*; D014765:Viral Vaccines / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D019444:Vaccines, DNA; D014765:Viral Vaccines