title: Vascular endothelial growth factor and its soluble receptor in infants with congenital cardiac disease.
abstract: Patients with cyanotic congenital cardiac disease often develop major aortopulmonary collaterals. Vascular endothelial growth factor is a key promoter of angiogenesis. Its soluble receptor-1 acts as a potent antagonist. We studied 30 infants with cyanotic congenital cardiac disease and 27 infants with acyanotic congenital cardiac disease. Central venous plasma vascular endothelial growth factor and soluble vascular endothelial growth factor receptor-1 levels were measured before, and 24 and 96 hours after surgery. There was no difference between plasma vascular endothelial growth factor levels in infants with cyanotic and those with acyanotic congenital cardiac disease. In cyanotic infants, the soluble vascular endothelial growth factor receptor-1 levels tended to be higher than in the acyanotic infants. In conclusion, there is no significant difference in the plasma levels of vascular endothelial growth factor and its soluble receptor-1 between infants with cyanotic and those with acyanotic congenital cardiac disease.
authors.affiliation: Department of Neonatology, Charité University Medicine Berlin, Germany. anja.pohl@charite.de
authors.forename: Anja
authors.initials: A
authors.lastname: Pohl-Schickinger
authors.forename: Petra
authors.initials: P
authors.lastname: Koehne
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz
authors.forename: Katharina R L
authors.initials: KR
authors.lastname: Schmitt
authors.forename: Michael
authors.initials: M
authors.lastname: Hübler
authors.forename: Matthias
authors.initials: M
authors.lastname: Redlin
authors.forename: Felix
authors.initials: F
authors.lastname: Berger
authors.forename: Brigitte
authors.initials: B
authors.lastname: Stiller
mesh_terms: D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1