Lysosomal Rag-ulation of mTOR complex 1 activity.
An amino acid-sensing pathway regulates mTOR complex 1 (mTORC1) activity and participates in nutrient control of cell metabolism and growth. Sancak et al. (2010) identify a lysosomal membrane-localized super-complex that drives amino acid-dependent mTORC1 activation.
Abraham
Robert T
RT
Center for Integrative Biology and Biotherapeutics, Pfizer Biopharmaceuticals, 401 N. Middletown Road, Pearl River, NY 10965, USA.