title: Relationship between alcohol consumption and serum adiponectin levels: the Takahata study--a cross-sectional study of a healthy Japanese population.
abstract: BACKGROUND
  The relationship between alcohol consumption and serum adiponectin levels has not been fully explored in an Asian population.
  
  
  OBJECTIVE
  Our goal was to determine whether alcohol consumption is associated with a change in adiponectin levels in a healthy Japanese population.
  
  
  METHODS
  This was a cross-sectional study.
  
  
  METHODS
  Subjects were recruited from participants in a health check-up program.
  
  
  METHODS
  This study included 2932 subjects (1306 men and 1626 women).
  
  
  METHODS
  The effects of total weekly or daily volume of ethanol intake on serum adiponectin levels were evaluated. In addition, the correlation of clinical traits with serum adiponectin levels was examined. A multivariate regression model was used to control for possible confounding factors.
  
  
  RESULTS
  Alcohol consumption was weakly correlated with decreased serum adiponectin levels in men [Spearman's ordered correlation coefficient (rs=-0.141; P<0.001]; an even weaker correlation was seen in women (rs=-0.055; P=0.025). Multivariate analysis demonstrated that alcohol consumption was independently associated with hypoadiponectinemia.
  
  
  CONCLUSIONS
  In contrast to reports from the United States and Europe among White and Black subjects, our study demonstrated an inverse association between alcohol intake and serum adiponectin levels in Asian subjects, suggesting ethnic differences in the effects of alcohol consumption on serum adiponectin levels.
authors.affiliation: Department of Gastroenterology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. ynishise-gi@umin.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nishise
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Naohiko
authors.initials: N
authors.lastname: Makino
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumoto
authors.forename: Jun-Itsu
authors.initials: JI
authors.lastname: Ito
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Saito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Togashi
authors.forename: Chisaki
authors.initials: C
authors.lastname: Ikeda
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
authors.forename: Makoto
authors.initials: M
authors.lastname: Daimon
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Fukao
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000097:blood*; D044466:Asian People; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006306:Health Surveys; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012907:Smoking
chemical_list: D052242:Adiponectin