Indinavir-induced nephrolithiasis three and one-half years after cessation of indinavir therapy.
Nephrolithiasis is a known side effect of indinavir sulfate, a protease inhibitor used in the treatment of human immunodeficiency virus (HIV). The duration of its side effects, however, has not been well defined. We present a case where a patient presented with symptomatic indinavir-induced nephrolithiasis 3.5 years after discontinuing indinavir. We use this case to illustrate the pathophysiology of indinavir stones and hypothesize how they can occur years after discontinuation by discussing the pharmacokinetics of the drug.
Huynh
Julie
J
Division of Nephrology and Hypertension, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.
Hever
Aviv
A
Tom
Thomas
T
Sim
John J
JJ
D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis / Q000139:chemically induced*; D013997:Time Factors
D017320:HIV Protease Inhibitors; D019469:Indinavir
Clin Infect Dis. 1998 Dec;27(6):1536-7
9868678
Urology. 1997 Oct;50(4):508-11
9338723
Lancet. 1997 May 3;349(9061):1294-5
9142068
J Urol. 2003 Feb;169(2):475-7
12544290
J Urol. 1999 Jun;161(6):1765-8
10332431
J Antimicrob Chemother. 2007 Jan;59(1):114-7
17095526