Silica nanoparticle supported lipid bilayers for gene delivery.
Silica nanoparticle supported cationic lipids can effectively bind plasmid DNAs and transfect mammalian cells with an efficiency that depends on both the particle size and lipid composition; here the gene delivery and expression process has been confirmed by confocal fluorescence microscopy.
Liu
Juewen
J
Center for Micro-Engineered Materials, University of New Mexico, Albuquerque, NM, USA.
Stace-Naughton
Alison
A
Brinker
C Jeffrey
CJ
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry*; D018014:Gene Transfer Techniques; D008051:Lipid Bilayers / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010957:Plasmids; D012822:Silicon Dioxide / Q000737:chemistry*; D014162:Transfection
D008051:Lipid Bilayers; D012822:Silicon Dioxide; D004247:DNA
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