title: Maternal undernutrition influences placental-fetal development.
abstract: Maternal nutrition during pregnancy has a pivotal role in the regulation of placental-fetal development and thereby affects the lifelong health and productivity of offspring. Suboptimal maternal nutrition yields low birth weight, with substantial effect on the short-term morbidity of the newborn. The placenta is the organ through which gases, nutrients, and wastes are exchanged between the maternal-fetal circulations. The size, morphology, and nutrient transfer capacity of the placenta determine the prenatal growth trajectory of the fetus to influence birth weight. Transplacental exchange depends on uterine, placental, and umbilical blood flow. Most important, maternal nutrition influences factors associated not only with placental homeostasis but also with optimal fetal development. This review associates fetal growth with maternal nutrition during pregnancy, placental growth and vascular development, and placental nutrient transport.
authors.affiliation: Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, and David Geffen School of Medicine at UCLA, Torrance, California 90502, USA. lbelkacemi@obgyn.humc.edu
authors.forename: Louiza
authors.initials: L
authors.lastname: Belkacemi
authors.forename: D Michael
authors.initials: DM
authors.lastname: Nelson
authors.forename: Mina
authors.initials: M
authors.lastname: Desai
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ross
mesh_terms: D000818:Animals; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005317:Fetal Growth Retardation / Q000503:physiopathology; D006801:Humans; D044342:Malnutrition / Q000503:physiopathology*; D039382:Maternal Nutritional Physiological Phenomena / Q000502:physiology*; D010929:Placentation / Q000502:physiology; D011247:Pregnancy