title: Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.
abstract: The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.
authors.affiliation: Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, S3-137, Worcester, MA 01655, USA.
authors.forename: Kavitha
authors.initials: K
authors.lastname: Narayan
authors.forename: Joonsoo
authors.initials: J
authors.lastname: Kang
mesh_terms: D000818:Animals; D019070:Cell Lineage; D006801:Humans; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology* / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta
references.citation: J Immunol. 2002 Apr 15;168(8):3825-32
references.pmid: 11937535
references.citation: J Immunol. 2004 Jul 1;173(1):25-32
references.pmid: 15210755
references.citation: Proc Natl Acad Sci U S A. 1990 Apr;87(8):3067-71
references.pmid: 2326267
references.citation: Nat Rev Immunol. 2009 Jan;9(1):39-46
references.pmid: 19079134
references.citation: J Immunol. 2005 Mar 15;174(6):3153-7
references.pmid: 15749842
references.citation: Immunity. 2005 May;22(5):595-606
references.pmid: 15894277
references.citation: J Exp Med. 1996 May 1;183(5):2033-41
references.pmid: 8642314
references.citation: Immunol Rev. 2007 Feb;215:77-88
references.pmid: 17291280
references.citation: Immunity. 2008 Jul 18;29(1):90-100
references.pmid: 18585064
references.citation: J Exp Med. 1999 Oct 18;190(8):1093-102
references.pmid: 10523607
references.citation: J Exp Med. 2008 May 12;205(5):1173-86
references.pmid: 18443226
references.citation: Immunity. 2000 Jan;12(1):17-26
references.pmid: 10661402
references.citation: Semin Immunol. 1997 Jun;9(3):171-9
references.pmid: 9200328
references.citation: J Exp Med. 1994 Apr 1;179(4):1355-60
references.pmid: 8145048
references.citation: Science. 1991 Aug 16;253(5021):778-81
references.pmid: 1831564
references.citation: Immunity. 2009 Oct 16;31(4):565-75
references.pmid: 19833086
references.citation: Eur J Immunol. 2001 Oct;31(10):2901-9
references.pmid: 11592065
references.citation: Nat Immunol. 2002 May;3(5):489-96
references.pmid: 11927910
references.citation: Nat Immunol. 2008 Jul;9(7):777-84
references.pmid: 18516039
references.citation: Immunol Rev. 2009 Mar;228(1):115-31
references.pmid: 19290924
references.citation: J Exp Med. 1994 Feb 1;179(2):709-13
references.pmid: 8294878
references.citation: Immunity. 2008 Mar;28(3):359-69
references.pmid: 18342008
references.citation: Nat Med. 2005 Mar;11(3):340-5
references.pmid: 15711562
references.citation: J Exp Med. 2005 Mar 7;201(5):695-701
references.pmid: 15738056
references.citation: Immunity. 2006 Jul;25(1):105-16
references.pmid: 16814577
references.citation: J Immunol. 2010 Feb 1;184(3):1268-79
references.pmid: 20038637
references.citation: Nat Rev Immunol. 2008 Oct;8(10):788-801
references.pmid: 18802443
references.citation: Immunity. 2008 Sep 19;29(3):391-403
references.pmid: 18703361
references.citation: J Exp Med. 2008 Jan 21;205(1):245-56
references.pmid: 18195075
references.citation: Blood. 2008 Jan 1;111(1):160-4
references.pmid: 17855627
references.citation: Nat Immunol. 2008 Sep;9(9):1055-64
references.pmid: 18660811
references.citation: Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12522-7
references.pmid: 9770518
references.citation: Immunity. 1996 Oct;5(4):343-52
references.pmid: 8885867
references.citation: J Immunol. 2009 May 1;182(9):5306-16
references.pmid: 19380777
references.citation: Eur J Immunol. 1997 Feb;27(2):544-53
references.pmid: 9045929
references.citation: Immunity. 2007 Nov;27(5):775-85
references.pmid: 18031697
references.citation: J Exp Med. 1996 Dec 1;184(6):2423-7
references.pmid: 8976198
references.citation: Nat Immunol. 2003 Oct;4(10):991-8
references.pmid: 14502287
references.citation: Blood. 2008 Jan 1;111(1):142-9
references.pmid: 17906078
references.citation: J Exp Med. 1995 Sep 1;182(3):891-5
references.pmid: 7650493
references.citation: J Immunol. 1999 Mar 1;162(5):2575-80
references.pmid: 10072498
references.citation: Proc Natl Acad Sci U S A. 2009 May 19;106(20):8308-13
references.pmid: 19416854
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8
references.pmid: 19617548
references.citation: PLoS One. 2010 Feb 19;5(2):e9303
references.pmid: 20174563
references.citation: J Immunol. 1997 Jun 15;158(12):5744-50
references.pmid: 9190924
references.citation: J Immunol. 1998 Dec 1;161(11):5851-4
references.pmid: 9834063
references.citation: J Exp Med. 2005 Jul 4;202(1):111-21
references.pmid: 15998791
references.citation: Immunity. 2002 Jun;16(6):827-38
references.pmid: 12121664
references.citation: J Exp Med. 2003 Sep 15;198(6):957-62
references.pmid: 12975459
references.citation: Immunity. 1996 Dec;5(6):537-49
references.pmid: 8986714
references.citation: J Exp Med. 2001 Mar 19;193(6):689-98
references.pmid: 11257136
references.citation: J Immunol. 2004 Aug 15;173(4):2516-23
references.pmid: 15294967
references.citation: Nature. 1995 Mar 2;374(6517):70-4
references.pmid: 7870176
references.citation: J Exp Med. 2000 Aug 21;192(4):537-48
references.pmid: 10952723
references.citation: J Immunol. 2004 Aug 15;173(4):2307-14
references.pmid: 15294943
references.citation: Immunity. 1998 Apr;8(4):427-38
references.pmid: 9586633
references.citation: Blood. 2009 Jul 16;114(3):564-71
references.pmid: 19443662
references.citation: Immunity. 2005 May;22(5):583-93
references.pmid: 15894276
references.citation: Nat Immunol. 2003 Oct;4(10):999-1008
references.pmid: 12970761
references.citation: Mol Cell Biol. 2002 Feb;22(4):1184-93
references.pmid: 11809809
references.citation: Eur J Immunol. 2000 Jul;30(7):1988-97
references.pmid: 10940888
references.citation: Immunity. 1998 Jan;8(1):11-20
references.pmid: 9462507
references.citation: J Exp Med. 1999 Oct 4;190(7):973-82
references.pmid: 10510087
references.citation: Eur J Immunol. 1997 Nov;27(11):2948-58
references.pmid: 9394823
references.citation: Science. 2007 Jan 12;315(5809):230-3
references.pmid: 17218525
references.citation: Immunity. 1997 Jul;7(1):83-95
references.pmid: 9252122
references.citation: Nat Immunol. 2009 Apr;10(4):427-36
references.pmid: 19270712