Ionic mechanisms of the effects of sleep deprivation on excitability in hippocampal pyramidal neurons.
It has been confirmed that sleep has a key role in learning and memory. Our previous study indicated that paradoxical sleep deprivation (PSD) impairs spatial learning ability of rats, and the decrease in membrane excitability of CA1 pyramidal neurons contributes to deficits in performing a spatial learning task. To investigate the further ionic mechanisms, the persistent sodium currents (I(NaP)), the hyperpolarization-activated cation current (I(h)), and their roles in neuron excitability were detected. PSD decreased I(NaP) and suppressed spike ADP, which leads to the reduction of neuron excitability and to the increase of firing accommodation. In addition, PSD reduced the I(h) amplitude and the rebound excitability of CA1 pyramidal neurons. The results of the present study suggested that I(h) and I(NaP) contributed to the inhibitory effect of PSD on neuron excitability, further influencing learning and memory processing. Modulating the ion channels and increasing the membrane excitability of hippocampal neurons are possible targets for preventing the effects of paradoxical sleep deprivation.
Yang
Rui-Hua
RH
Department of Nutrition and Food Hygiene, the Fourth Military Medical University, Xi'an 710032, PR China. fmmur.young@gmail.com
Wang
Wen-Ting
WT
Hou
Xiang-Hong
XH
Hu
San-Jue
SJ
Chen
Jing-Yuan
JY
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D007858:Learning / Q000502:physiology; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000503:physiopathology*; D009433:Neural Inhibition / Q000502:physiology; D009924:Organ Culture Techniques; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012892:Sleep Deprivation / Q000503:physiopathology*; D015222:Sodium Channels / Q000502:physiology
D007473:Ion Channels; D015222:Sodium Channels