Methodological considerations treatment trials for persons personality disorder.
BACKGROUND
The National Institute of Mental Health convened an international group of experts to examine the conduct of treatment trials for persons with borderline personality disorder (BPD). The rapid growth of treatment research had led to the recognition that investigators face unique methodological issues with these challenging patients.


METHODS
Conference members reviewed critical aspects of psychotherapy and pharmacotherapy trial design for patients with BPD.


RESULTS
This article summarizes discussions held on March 17-18, 2005.


CONCLUSIONS
This paper addresses the most pressing issues in sample selection and trial design pertaining to BPD; issues that have bedeviled both investigators submitting applications and reviewers trying to assess the merit of these grants. By disseminating this work, conference members hope to make this process more consistent and productive for all concerned.
Zanarini
Mary C
MC
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. zanarini@mclean.harvard.edu
Stanley
Barbara
B
Black
Donald W
DW
Markowitz
John C
JC
Goodman
Marianne
M
Pilkonis
Paul
P
Lynch
Thomas R
TR
Levy
Kenneth
K
Fonagy
Peter
P
Bohus
Martin
M
Farrell
Joan
J
Sanislow
Charles
C
D001883:Borderline Personality Disorder / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002986:Clinical Trials as Topic; D006801:Humans; D018579:Patient Selection; D011613:Psychotherapy; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012107:Research Design
D011619:Psychotropic Drugs
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