title: Normal growth and intravascular volume status with good metabolic control during peritoneal dialysis in infancy.
abstract: The most demanding patient population on peritoneal dialysis (PD) consists of children under 2 years of age. Their growth is inferior to that of older children and maintaining euvolemia is difficult, especially in anuric patients. In this prospective study reported here, we enrolled 21 patients <2 years of age (mean 0.59 years) at onset of PD and monitored their uremia parameters and evaluated their nutrition. Since no good instrument currently exists for estimating intravascular volume status, we used traditional blood pressure measurements, echocardiography, and N-terminal atrial natriuretic peptide measurements. Growth was compared with midparental height. Metabolic control was good. Long-term hypertension was seen in 43% of the patients, but left ventricular hypertrophy decreased during the study period. Mean weekly urea Kt/V was 3.38 +/- 0.66 and creatinine clearance was 49 +/- 20 L/week per 1.73 m(2). Catch-up growth was documented in 57% of the patients during PD. However, these children did not attain their midparental height at the end of PD at a mean age of 1.71 years. Although favorable metabolic control and good growth were achieved during PD, these children lagged in term of their midparental height. We conclude that several instruments are needed for determining the management of intravascular volume status and that the control of calcium-phosphorus status is demanding.
authors.affiliation: Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. hanne.laakkonen@hus.fi
authors.forename: Hanne
authors.initials: H
authors.lastname: Laakkonen
authors.forename: Juha-Matti
authors.initials: JM
authors.lastname: Happonen
authors.forename: Eino
authors.initials: E
authors.lastname: Marttinen
authors.forename: Aila
authors.initials: A
authors.lastname: Paganus
authors.forename: Tuula
authors.initials: T
authors.lastname: Hölttä
authors.forename: Christer
authors.initials: C
authors.lastname: Holmberg
authors.forename: Kai
authors.initials: K
authors.lastname: Rönnholm
mesh_terms: D001002:Anuria / Q000378:metabolism; D002648:Child; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods*; D010758:Phosphorus; D011446:Prospective Studies; D014508:Urea / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism
chemical_list: D010758:Phosphorus; D014508:Urea; D003404:Creatinine
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