title: No long-term weight maintenance effects of gelatin in a supra-sustained protein diet.
abstract: In the short-term, gelatin showed stronger hunger suppression and less energy intake compared with other proteins. This study investigated if a supra-sustained gelatin-milk protein (GMP) diet improves weight maintenance (WM) compared with a sustained milk protein (SMP) diet and supra-sustained milk protein (SSMP) diet during a 4-months WM period after 8-week weight loss (WL) in sixty-five healthy subjects (28.6+/-3.4kg/m(2); 44+/-10years). Absolute protein intake was kept constant (sustained) throughout per subject. Diets were: protein(P)/fat(F)/carbohydrate(C): 15/40/45% of energy (En%) (SMP) and 30/25/45 En% (SSMP or GMP) for weeks 9-16. Diets on weeks 17-24: P/F/C: 30/35/35 En% (SMP) and 60/5/35 En% (SSMP or GMP). From weeks 8 to 16, and weeks 16 to 24, changes in BMI were similar between the GMP (-0.4+/-0.6 and 0.3+/-0.7kg/m(2) respectively), and the SMP (-0.7+/-0.9 and 0.1+/-0.7kg/m(2) respectively) and SSMP (-0.6+/-0.6 and 0.3+/-0.6kg/m(2) respectively) diets. Sparing of fat free mass (FFM): increases/decreases in FFM%/fat-mass% from weeks 8 to 16 were similar between the GMP and both control diets, and maintained from weeks 16 to 24. In conclusion, all 3 diets resulted in a successful WM period, while a GMP diet does not improve body weight maintenance and related variables after weight loss compared with a SMP and SSMP diet.
authors.affiliation: NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Centre+, PO Box 616, 6200 MD Maastricht, The Netherlands. ananda.waelen@hb.unimaas.n
authors.forename: A
authors.initials: A
authors.lastname: Hochstenbach-Waelen
authors.forename: K R
authors.initials: KR
authors.lastname: Westerterp
authors.forename: S
authors.initials: S
authors.lastname: Soenen
authors.forename: M S
authors.initials: MS
authors.lastname: Westerterp-Plantenga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001774:Blood Chemical Analysis / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D016503:Drug Delivery Systems; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D005780:Gelatin / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009765:Obesity / Q000178:diet therapy* / Q000503:physiopathology; D016037:Single-Blind Method; D013997:Time Factors; D055105:Waist Circumference / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects*; D055815:Young Adult
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D005780:Gelatin