Acquisition of an active avoidance reaction in rats and morphological changes in the hippocampus in pentylenetetrazol kindling.
The relationship between measures of active avoidance behavior and morphological changes in the hippocampus was studied in rats after kindling induced by administration of pentylenetetrazol. Pentylenetetrazol kindling impaired the acquisition of the avoidance reaction and increased the number of intersignal reactions without altering the acquisition of the avoidance reaction in the shuttle box in rats. The numbers of neurons in the hippocampus (fields CA1 and CA3) and dentate fascia decreased, while the numbers of damaged neurons increased. Inverse correlations between seizure severity and the numbers of neurons in hippocampal fields CA1 and CA3 and the dentate fascia were seen in rats subjected to kindling. Rats of this group also showed positive correlations between seizure severity and the numbers of damaged neurons in field CA1 and the dentate fascia. There were no correlations between measures of convulsive activity or the number of cells in hippocampal zones and measures of the acquired avoidance behavior. Control animals showed negative correlations between the numbers of damaged cells in field CA1 and the dentate fascia and the characteristics of avoidance behavior in the first and third training sessions.
Pavlova
T V
TV
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Stepanichev
M Y
MY
Gekht
A B
AB
Gulyaeva
N V
NV
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D018756:GABA Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D007696:Kindling, Neurologic; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology
D018756:GABA Antagonists; D010433:Pentylenetetrazole
Brain Res. 1990 Sep 10;527(1):1-6
2282474
J Comp Physiol Psychol. 1975 Sep;89(7):759-77
1176670
Zh Vyssh Nerv Deiat Im I P Pavlova. 2003 Jan-Feb;53(1):110-2
12669512
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1118-22
9927703
Prog Neurobiol. 1984;22(2):131-53
6433403
Epilepsia. 1972 Sep;13(5):663-74
4563784
Pharmacol Biochem Behav. 2002 Nov;73(4):851-61
12213531
Exp Neurol. 1969 Nov;25(3):295-330
4981856
Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):291-303
11701200
Behav Neural Biol. 1992 Jan;57(1):37-43
1567332
Neurosurgery. 1993 Apr;32(4):574-80; discussion 580-1
8474648
Pediatr Dev Pathol. 2005 Nov-Dec;8(6):607-14
16333693
Eur Neuropsychopharmacol. 1995 Mar;5(1):53-6
7613103
Pharmacol Biochem Behav. 2000 Jan 1;65(1):23-30
10638631
Pharmacol Res. 1997 Jan;35(1):27-32
9149312
Epilepsy Behav. 2005 Dec;7(4):629-38
16246633
J Comp Physiol Psychol. 1976 Nov;90(11):1035-50
993387
Neurology. 2001 Jul 24;57(2):315-7
11468318
Neurosci Biobehav Rev. 2001 Dec;25(7-8):687-96
11801294
J Neurosci. 1994 May;14(5 Pt 2):3106-21
8182460
J Comp Neurol. 1996 Sep 30;373(4):593-618
8889946
Anxiety. 1996;2(3):109-16
9160611
Physiol Behav. 2004 Feb;80(5):647-55
14984798
J Neurophysiol. 2000 Dec;84(6):3088-90
11110837
Neurosci Lett. 2006 Jan 9;392(1-2):154-8
16242239
Psychopharmacologia. 1971;20(3):213-29
5565253
Seizure. 1997 Dec;6(6):467-74
9530943