title: Carbon metabolism of intracellular bacterial pathogens and possible links to virulence.
abstract: New technologies such as high-throughput methods and 13C-isotopologue-profiling analysis are beginning to provide us with insight into the in vivo metabolism of microorganisms, especially in the host cell compartments that are colonized by intracellular bacterial pathogens. In this Review, we discuss the recent progress made in determining the major carbon sources and metabolic pathways used by model intracellular bacterial pathogens that replicate either in the cytosol or in vacuoles of infected host cells. Furthermore, we highlight the possible links between intracellular carbon metabolism and the expression of virulence genes.
authors.affiliation: Lehrstuhl für Biochemie, Technische Universität München, D-85747 Garching, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eisenreich
authors.forename: Thomas
authors.initials: T
authors.lastname: Dandekar
authors.forename: Jürgen
authors.initials: J
authors.lastname: Heesemann
authors.forename: Werner
authors.initials: W
authors.lastname: Goebel
mesh_terms: D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002244:Carbon / Q000378:metabolism*; D003600:Cytosol / Q000382:microbiology; D044404:Genomic Islands; D054884:Host-Pathogen Interactions; D008089:Listeria monocytogenes / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D010454:Peptide Termination Factors / Q000235:genetics / Q000378:metabolism; D012485:Salmonella typhi / Q000378:metabolism / Q000472:pathogenicity; D012763:Shigella flexneri / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D014617:Vacuoles / Q000382:microbiology; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D010454:Peptide Termination Factors; C545356:PrfA protein, Listeria monocytogenes; D037521:Virulence Factors; D002244:Carbon
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