Comparison of structure-dependent hormetic cytotoxicity induced by coplanar and non-coplanar PCB congeners.
The effect of polychlorinated biphenyls (PCBs) on Vero cell proliferation was investigated, with the attempts to assess the possible hormetic dose-response and to compare their structure-dependent toxicity. Both PCB congeners revealed low doses stimulation in our experiment. However, significant cytotoxicity was only observed in PCB 52 concentrations larger than 0.1 microg ml(-1), while there was no significant inhibition in PCB 77-treated cells at concentrations selected. Furthermore, the time-dependent cytotoxic trends were different. The comparison between PCB 52 and PCB 77 indicated that the cytotoxic mechanisms involved in coplanar or non-coplanar PCB congener exposure were different, and this difference might be associated with individual genotoxicity and the release of contact inhibition, respectively.
Chen
Yingxu
Y
Ministry of Agriculture Key Laboratory of Non-point Source Pollution Control, Institute of Environmental Science and Technology, Zhejiang University, Hangzhou 310029, China. yxchen@zju.edu.cn
Shen
Kaili
K
Shen
Chaofeng
C
Chen
Lei
L
Chen
Xincai
X
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D011078:Polychlorinated Biphenyls / Q000737:chemistry* / Q000494:pharmacology; D014709:Vero Cells
D011078:Polychlorinated Biphenyls