title: Visual acuity and foveal thickness after vitrectomy for macular edema.
abstract: The outcome of vitrectomy for macular edema was examined in patients with central retinal vein occlusion (CRVO), as well as whether vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) levels in vitreous fluid influence the visual prognosis and macular edema. Twenty-six consecutive patients with CRVO and macular edema underwent vitrectomy. Best-corrected visual acuity, retinal thickness, and the VEGF and IL-6 levels in vitreous fluid were measured before and after surgery. Both visual acuity and retinal thickness were significantly improved at 6 months postoperatively (p = 0.0114 and p < 0.0001, respectively). The vitreous VEGF level was significantly higher in patients who showed less improvement of visual acuity (p = 0.0182). In contrast, a high vitreous VEGF level was associated with greater improvement of macular edema (p = 0.0199). These results suggest that the vitreous VEGF level may be correlated with the visual prognosis and changes of macular edema in CRVO patients after vitrectomy.
authors.affiliation: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan. nomahide@tymc.twmu.ac.jp
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Noma
authors.forename: Hideharu
authors.initials: H
authors.lastname: Funatsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.forename: Katsunori
authors.initials: K
authors.lastname: Shimada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005139:Eyeglasses; D005260:Female; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008269:Macular Edema / Q000150:complications / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D012170:Retinal Vein Occlusion / Q000150:complications; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D042461:Vascular Endothelial Growth Factor A