Indacaterol for chronic obstructive pulmonary disease (COPD).
Indacaterol (Onbrez), previously known as QAB-149-AFA, is a novel ultra-long-acting beta2-adrenoceptor agonist that was recently approved by the European Commission as a new once-daily maintenance bronchodilator treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease (COPD). COPD is a major cause of chronic morbidity worldwide. According to World Health Organisation, it was the fifth cause of death in 2002 and it is projected to be the fourth cause of mortality by 2030. The rapid onset of action of indacaterol, duration of bronchodilation for at least 24 hours, and an optimal safety profile make this drug an interesting and attractive weapon for its use in fight against the COPD.
Cazzola
Mario
M
Unit of Respiratory Clinical Pharmacology, Department of Internal Medicine, University of Rome "Tor Vergata", Rehabilitative Pneumology, IRCCS, San Raffaele Pisana, Rome, Italy. mario.cazzola@uniroma2.it
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D000318:Adrenergic beta-Agonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D006801:Humans; D007189:Indans / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D015363:Quinolones / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D007189:Indans; D015363:Quinolones; C510790:indacaterol