Bimatoprost in the treatment of eyelash hypotrichosis.
Eyelashes hypotrichosis is a condition indicated by an inadequate amount of eyelashes. Hypertrichosis of eyelashes, characterized by excessive eyelash growth, is a regular phenomenon associated with ophthalmic prostaglandin and prostamide analogs. Recently, the US Food and Drug Administration approved Latisse((R)) (bimatoprost 0.03% solution), identical to the ophthalmic solution for glaucoma treatment, for increasing eyelash length, thickness and darkness in patients with hypotrichosis of the eyelashes. When prostaglandin and prostamide analogs interact with the prostanoid receptors in the hair follicle, this most likely stimulates the resting follicles (telogen phase) to growing follicles (anagen phase). Prostaglandin and prostamide analogs may also prolong the anagen phase of eyelashes, leading to an increase of eyelash length. Although bimatoprost is effective in promoting increased growth of healthy eyelashes and adnexal hairs, its effectiveness in patients with eyelash alopecia areata is debatable and its protective effect is not yet studied in patients with eyelash loss secondary to radiation or chemotherapy. Bimatoprost is generally safe when applied to the base of the eyelashes at the lid margin with minimum side effects. However, other ocular or systemic side effects associated with ophthalmic prostaglandin and prostamide analogs may occur when instilled on the surface of the eye, and patients must be informed and monitored.
Law
Simon K
SK
Jules Stein Eye Institute, University of California, Los Angeles, California, USA. law@jsei.ucla.edu
Am J Ophthalmol. 1997 Oct;124(4):544-7
9323945
JAMA. 1979 Jul 13;242(2):142
448883
Vitam Horm. 2009;81:469-85
19647123
Arch Ophthalmol. 2001 Jul;119(7):994-1000
11448321
Ophthalmology. 2001 Jun;108(6):1023-31; discussion 1032
11382623
Am J Ophthalmol. 2003 May;135(5):688-703
12719078
J Cataract Refract Surg. 2003 Nov;29(11):2242-3
14670442
Ophthalmology. 2005 Feb;112(2):262-6
15691561
Biochem Biophys Res Commun. 2002 Jan 18;290(2):696-700
11785955
Arch Ophthalmol. 2000 May;118(5):718-9
10815168
Arch Ophthalmol. 2005 Nov;123(11):1541-6
16286616
N Engl J Med. 1999 Aug 12;341(7):491-7
10441606
Acta Derm Venereol. 2002;82(1):7-12
12013211
Surv Ophthalmol. 2001 May;45 Suppl 4:S353-60
11434938
J Ocul Pharmacol Ther. 2003 Jun;19(3):233-45
12828841
J Drugs Dermatol. 2004 Sep-Oct;3(5):571-2
15552614
Exp Dermatol. 2008 Jan;17(1):63-72
18005048
J Invest Dermatol. 1993 Jul;101(1 Suppl):135S-137S
8326147
Arch Ophthalmol. 1997 Sep;115(9):1206-8
9298071
Am J Ophthalmol. 2001 Oct;132(4):472-84
11589866
Adv Ther. 2001 May-Jun;18(3):110-21
11571823
Am J Ophthalmol. 2003 Jan;135(1):55-63
12504698
Am J Ophthalmol. 2005 May;139(5):932-3
15860312
Ophthalmic Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7
18645437
Eur J Ophthalmol. 2006 Mar-Apr;16(2):247-50
16703542
Clin Exp Dermatol. 2010 Jun;35(4):e161-2
19925481
Endocr Rev. 2000 Aug;21(4):363-92
10950157
Nurs Womens Health. 2009 Jun;13(3):243-8
19523139
Int J Radiat Biol. 1992 Apr;61(4):533-7
1349335
Br J Pharmacol. 2008 Jul;154(5):1079-93
18587449
Ophthalmology. 2006 Nov;113(11):1961-7
16935336
Med Biol Eng Comput. 1979 May;17(3):333-6
317330
Am J Ophthalmol. 2003 May;135(5):713-5
12719085
Comput Methods Programs Biomed. 2007 Aug;87(2):93-103
17576020
Am J Ophthalmol. 2005 Jan;139(1):202-3
15652856
J Eur Acad Dermatol Venereol. 2004 Sep;18(5):644-5
15324422
Arch Ophthalmol. 2001 Feb;119(2):300-1
11176999
Br J Pharmacol. 2008 Feb;153(3):410-9
17721551
Curr Probl Dermatol. 1984;12:1-58
6209067
Am J Ophthalmol. 2004 May;137(5):966-8
15126179
Am J Ophthalmol. 2003 Mar;135(3):314-20
12614748
Am J Ophthalmol. 2006 Dec;142(6):1059-60
17157592
Ophthalmology. 2007 Jul;114(7):1255-8
17306877
J Invest Dermatol. 1991 Aug;97(2):264-8
1830074
Clin Dermatol. 1988 Oct-Dec;6(4):119-21
3214817
J Am Acad Dermatol. 2001 Apr;44(4):721-3
11260563
Invest Ophthalmol Vis Sci. 2001 May;42(6):1134-45
11328719
Ocul Immunol Inflamm. 2003 Mar;11(1):67-71
12854029
Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4123-8
17724196
Klin Monbl Augenheilkd. 2008 May;225(5):443-5
18454393
Surv Ophthalmol. 2001 May;45 Suppl 4:S337-45
11434936
Ophthalmic Plast Reconstr Surg. 2004 Jul;20(4):320-2
15266150
Ophthalmic Plast Reconstr Surg. 1997 Mar;13(1):21-5
9076779
Am J Ophthalmol. 2001 Jul;132(1):114-6
11438068
Am J Ophthalmol. 1999 May;127(5):602-4
10334356
Horm Res. 2000;54(5-6):243-50
11595812
Surv Ophthalmol. 2001 May;45 Suppl 4:S361-8
11434939
Acta Ophthalmol Scand. 1999 Dec;77(6):668-72
10634560
Br J Dermatol. 2010 Feb 1;162(2):304-10
19804590
Am J Ophthalmol. 2004 Apr;137(4):756-7
15059720
Pediatrics. 2005 Jan;115(1):e86-91
15629970
Surv Ophthalmol. 2002 Aug;47 Suppl 1:S185-202
12204716
Am J Ophthalmol. 1999 May;127(5):531-6
10334345
Ann Pharmacother. 1998 Apr;32(4):504-5
9562149
J Am Acad Dermatol. 2009 Sep;61(3):530-2
19700021
J Eur Acad Dermatol Venereol. 2007 Mar;21(3):421-3
17309487
Am J Ophthalmol. 2004 May;137(5):965-6
15126178
J Pharmacol Exp Ther. 2003 May;305(2):772-85
12606640
J Am Acad Dermatol. 2004 Nov;51(5):843
15523378
Arch Ophtalmol (Paris). 1977;37(11):697-708
147666
Ophthalmology. 1998 Feb;105(2):263-8
9479285
J Invest Dermatol. 1997 Feb;108(2):205-9
9008235
Arch Dermatol. 1969 Sep;100(3):328-35
5822379
Am J Ophthalmol. 2002 Mar;133(3):401-3
11860979
Rev Physiol Biochem Pharmacol. 2008;160:1-24
18481028
J Am Acad Dermatol. 2009 Apr;60(4):705-6
19293023
BMJ. 2001 Oct 6;323(7316):783
11588081
Jpn J Ophthalmol. 2009 Mar;53(2):176-179
19333704
Exp Dermatol. 2005 May;14(5):323-8
15854125
J Neuroendocrinol. 2008 May;20 Suppl 1:1-9
18426492
Eye (Lond). 2003 Apr;17(3):444-6
12724722
Br J Dermatol. 2006 Dec;155(6):1170-6
17107385
Optom Vis Sci. 2004 Aug;81(8):574-7
15300114
Am J Ophthalmol. 2004 Aug;138(2):305-6
15289149
Exp Dermatol. 2007 Sep;16(9):762-9
17697149
Indian J Ophthalmol. 2006 Mar;54(1):47-8
16531673
Exp Eye Res. 2003 Dec;77(6):721-30
14609560
Am J Ophthalmol. 1998 Jul;126(1):37-41
9683147
Surv Ophthalmol. 1997 Feb;41 Suppl 2:S129-38
9154289
Nippon Ganka Gakkai Zasshi. 2006 Aug;110(8):581-7
16972649
Int J Radiat Oncol Biol Phys. 1992;23(2):333-7
1587754
Int J Dermatol. 1995 Mar;34(3):149-58
7751086