Herpes simplex virus type 1 persists in the aged brain through hypothetical expression of accessory genes.
Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer's disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses through an array of accessory genes. This mini-review focuses on these viral accessory genes that may shed light on the potential mechanisms of this enigmatic phenomenon in the elderly brain.
Mori
Isamu
I
Faculty of Health and Nutrition, Shubun University, Aichi, Japan. mori@shubun-ac.jp
D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000821:virology*; D001921:Brain / Q000821:virology; D020803:Encephalitis, Herpes Simplex / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D006561:Herpes Simplex / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000254:growth & development; D006801:Humans
J Virol. 2005 May;79(10):6162-71
15858001
Lancet. 1997 Jan 25;349(9047):241-4
9014911
J Neurovirol. 2007;13(1):56-66
17454449
Cell Host Microbe. 2007 Mar 15;1(1):23-35
18005679
Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):843-8
9023344
J Neuroimmunol. 2010 Mar 30;220(1-2):1-9
19819030
Neuropathol Appl Neurobiol. 1994 Jun;20(3):253-60
7936075
Microbes Infect. 2006 Aug;8(9-10):2556-62
16859952
J Med Virol. 2005 Feb;75(2):300-6
15602731
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9411-6
15192152
J Alzheimers Dis. 2009;16(1):1-14
19158416
EMBO J. 1996 Jul 1;15(13):3256-66
8670826
Virol J. 2008 Nov 21;5:140
19025601
Blood. 2009 Apr 2;113(14):3264-75
18952891
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):978-83
11773630
Biochemistry. 2000 May 23;39(20):5988-94
10821670
J Virol. 2004 Feb;78(4):1675-84
14747533
Neurosci Lett. 2007 Dec 18;429(2-3):95-100
17980964
J Neurovirol. 2008 Jan;14(1):1-4
18300070
J Virol. 2002 Mar;76(5):2029-35
11836380
Glia. 2001 Nov;36(2):118-24
11596120
J Virol. 2009 Oct;83(20):10677-83
19656888
J Virol. 2009 Sep;83(18):9131-9
19587058
J Neuropathol Exp Neurol. 2006 Oct;65(10):1022-30
17021407
J Alzheimers Dis. 2009;16(2):341-50
19221424
J Immunol. 2001 Oct 1;167(7):3928-35
11564811
Cell Death Differ. 2003 Dec;10(12):1320-8
12934063
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2827-32
16477041
J Gen Virol. 2010 Apr;91(Pt 4):858-66
19955563
Autophagy. 2006 Jan-Mar;2(1):24-9
16874088
J Gen Virol. 2000 Mar;81(Pt 3):649-62
10675402
J Virol. 2004 Sep;78(18):10193-6
15331752
J Alzheimers Dis. 2008 May;13(4):393-405
18487848
J Pathol. 2009 Jan;217(1):131-8
18973185
J Biol Chem. 2002 Sep 20;277(38):35019-24
12119288
J Neurovirol. 2005 Apr;11(2):129-37
16036791
J Virol. 2003 Jun;77(12):7101-5
12768029
J Virol. 2009 Sep;83(17):8315-26
19570876
J Virol. 2002 Jul;76(14):6974-86
12072498
J Neurol Neurosurg Psychiatry. 1984 Nov;47(11):1247-50
6094737
J Virol. 2009 May;83(10):4791-9
19279108
J Virol. 2009 Dec;83(23):12164-71
19759141
Rev Med Virol. 2004 Jan-Feb;14(1):33-46
14716690
Science. 2008 Oct 10;322(5899):268-71
18845757
J Immunol. 2003 Dec 15;171(12):6733-41
14662877
J Med Virol. 2004 Sep;74(1):102-6
15258975
J Virol. 2002 Sep;76(18):9232-41
12186907
J Med Virol. 2004 Aug;73(4):605-11
15221907
Virology. 2000 Dec 20;278(2):309-21
11118355