title: Juvenile idiopathic arthritis and Wegener's granulomatosis--causal or casual acquaintances?
abstract: We report two cases of long-term juvenile idiopathic arthritis which developed recurrent subglottic stenosis secondary to localized Wegener's granulomatosis. In both cases, the biopsies taken from the affected region shown granulomatous vasculitis with multinucleated giant cells. Both patients presented positive serology for antineutrophil cytoplasmic antibodies by immunofluorescence (c-ANCA) and ELISA (PR3). The involvement or other organs was ruled out at the time of Wegener's granulomatosis diagnosis and during follow-up. To our knowledge, this is the first report of the association between juvenile idiopathic arthritis and a localized form of Wegener's granulomatosis.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan. 14000 Mexico D.F., Mexico. jjakez_ocampo@yahoo.com
authors.forename: Juan
authors.initials: J
authors.lastname: Jakez-Ocampo
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Ramírez
authors.forename: Carmen María
authors.initials: CM
authors.lastname: Paulín-Vera
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Flores-Suárez
authors.forename: Edgardo
authors.initials: E
authors.lastname: Reyes
authors.forename: Luis
authors.initials: L
authors.lastname: Llorente
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001171:Arthritis, Juvenile / Q000150:complications*; D001706:Biopsy; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D013997:Time Factors; D014657:Vasculitis / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic