title: Encapsulating peritoneal sclerosis: experience of a tertiary referral center.
abstract: OBJECTIVE
  Encapsulating peritoneal sclerosis (EPS) is arguably the most serious complication of chronic peritoneal dialysis (PD) therapy with extremely high mortality rates. We aimed to establish the rates of EPS and factors associated with its development in a single center.
  
  
  METHODS
  We retrospectively reviewed the records of all our PD patients from 1 January 1989 until 31 December 2008. All suspected cases were confirmed at laparotomy. Multifactorial models adjusted for potentially confounding variables such as age and sex.
  
  
  RESULTS
  Eleven cases of EPS were identified giving a prevalence rate of 1.98%. Median duration on PD was substantially longer in affected versus unaffected patients (42.5 months versus 13.8 months; p = 0.0002). EPS patients had experienced a mean of 3.54 previous cases of peritonitis (1 infection per year versus 0.71 per year in unaffected patients; p = 0.075). Six patients died (54.5%) due to intra-abdominal sepsis including all five who presented with small bowel obstruction. Three patients had an omentectomy and adhesiolysis performed with a successful outcome.
  
  
  CONCLUSIONS
  Our study reinforces the link between duration on PD and EPS. While mortality was high in our cohort, emerging surgical techniques demonstrate a favorable outcome that can be achieved even in severely affected cases.
authors.affiliation: Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland. paulphel@gmail.com
authors.forename: P J
authors.initials: PJ
authors.lastname: Phelan
authors.forename: J J
authors.initials: JJ
authors.lastname: Walshe
authors.forename: A
authors.initials: A
authors.lastname: Al-Aradi
authors.forename: J P
authors.initials: JP
authors.lastname: Garvey
authors.forename: K
authors.initials: K
authors.lastname: Finnegan
authors.forename: P
authors.initials: P
authors.lastname: O'Kelly
authors.forename: J
authors.initials: J
authors.lastname: McWilliams
authors.forename: J P
authors.initials: JP
authors.lastname: Ti
authors.forename: M M
authors.initials: MM
authors.lastname: Morrin
authors.forename: N
authors.initials: N
authors.lastname: Morgan
authors.forename: P J
authors.initials: PJ
authors.lastname: Conlon
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000401:mortality; D056627:Peritoneal Fibrosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric