Zn(OTf)(2)-catalyzed addition of amines to carbodiimides: efficient synthesis of guanidines and unpredicted formation of Zn-N amido species.
Zn(OTf)(2) acts as an excellent catalyst precursor for addition of various amine N-H bonds to carbodiimides under an atmosphere of air, offering a convenient synthesis of substituted guanidines with high functional-group tolerance. A Zn-N amido species is shown to act as the active species.
Li
Dongzhen
D
Beijing National Laboratory for Molecular Sciences (BNLMS), and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Guang
Jie
J
Zhang
Wen-Xiong
WX
Wang
Yang
Y
Xi
Zhenfeng
Z
D000588:Amines / Q000737:chemistry*; D002234:Carbodiimides / Q000737:chemistry*; D002384:Catalysis; D006146:Guanidines / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D017967:Zinc Compounds / Q000737:chemistry*
D000588:Amines; D002234:Carbodiimides; D006146:Guanidines; D017967:Zinc Compounds