title: Bilateral dystrophic calcinosis circumscripta in a cynomolgus macaque (Macaca fascicularis).
abstract: The authors describe a case in which well-circumscribed, expansile, and nonencapsulated nodular masses with missing digits were detected on the right and left feet in a 6-year-old female cynomolgus macaque from a routine toxicology study. Grossly, these masses were composed of variably sized and firm nodules containing white, chalklike material in the subcutaneous tissue on cross section. Microscopically, the nodules were composed of irregular lobules containing amorphous to granular, light to dark basophilic material that was surrounded by macrophages and multinucleated giant cells and separated by fibrous connective tissue. The nodule's contents were von Kossa and Alizarin red S positive. Serum calcium and phosphorus levels of this monkey were within normal ranges. Based on the gross pathology, histopathology, serum chemistry, and histochemistry, a diagnosis of dystrophic calcinosis circumscripta was made. Dystrophic calcinosis circumscripta is an uncommon syndrome of mineralization that occurs following tissue damage, without abnormalities in calcium and phosphorus homeostasis, and it is characterized by deposition of calcium salts in soft tissues. To the best of the authors' knowledge, this is the first report of dystrophic calcinosis circumscripta in a cynomolgus macaque.
authors.affiliation: Pfizer Research and Development, Drug Safety R&D, Cambridge, Massachusetts 02140, USA. zaher.radi@pfizer.com
authors.forename: Zaher A
authors.initials: ZA
authors.lastname: Radi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D002118:Calcium / Q000378:metabolism; D005260:Female; D005528:Foot / Q000473:pathology; D005534:Foot Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006651:Histocytochemistry; D008252:Macaca fascicularis; D014034:Toes / Q000473:pathology
chemical_list: D002118:Calcium