title: Endothelin--biology and disease.
abstract: Endothelins are important mediators of physiological and pathophysiologic processes including cardiovascular disorders, pulmonary disease, renal diseases and many others. Additionally, endothelins are involved in many other important processes such as development, cancer biology, wound healing, and even neurotransmission. Here, we review the cell and molecular biology as well as the prominent pathophysiological aspects of the endothelin system.
authors.affiliation: Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX 75390-8887, United States.
authors.forename: Al-Karim
authors.initials: AK
authors.lastname: Khimji
authors.forename: Don C
authors.initials: DC
authors.lastname: Rockey
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000378:metabolism; D016232:Endothelins / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D008171:Lung Diseases / Q000378:metabolism; D017466:Receptors, Endothelin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016232:Endothelins; D017466:Receptors, Endothelin