The impact of testosterone administration to female-to-male transsexuals on insulin resistance and lipid parameters compared with women with polycystic ovary syndrome.
OBJECTIVE
To evaluate the impact of testosterone (T) administration to female-to-male transsexuals (FtMs) on insulin resistance and lipid parameters and to compare the effects with women with polycystic ovary syndrome (PCOS).


METHODS
Cohort analysis.


METHODS
University hospital.


METHODS
Twenty-nine FtMs and 240 women with PCOS.


METHODS
Screening panel, ultrasound of the ovaries, hormone, lipid, and glucose and insulin measurements.


METHODS
Endocrine, metabolic parameters, and insulin resistance.


RESULTS
The PCOS women had significantly higher fasting, 1-h, and 2-h insulin levels and a significantly lower insulin sensitivity index compared with FtMs before and after their T treatment. There were higher triglyceride levels and lower high-density lipoprotein cholesterol levels upon T treatment in FtMs compared with the PCOS women. Women with PCOS had higher body mass index (BMI) values. Positive correlations between insulin resistance indices and BMI were found only in women with PCOS.


CONCLUSIONS
Testosterone administration by itself showed little detrimental influence on insulin resistance indices, but it had significant effects on lipid profiles. Compared with T, BMI had a greater impact on insulin resistance in women with PCOS.
Cupisti
Susanne
S
Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany.
Giltay
Erik J
EJ
Gooren
Louis J
LJ
Kronawitter
Desiree
D
Oppelt
Patricia G
PG
Beckmann
Matthias W
MW
Dittrich
Ralf
R
Mueller
Andreas
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism*; D013739:Testosterone / Q000008:administration & dosage* / Q000494:pharmacology; D014189:Transsexualism / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D055815:Young Adult
D008055:Lipids; D013739:Testosterone