title: Peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy.
abstract: Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy.
authors.affiliation: Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
authors.forename: Han-Chung
authors.initials: HC
authors.lastname: Wu
authors.forename: De-Kuan
authors.initials: DK
authors.lastname: Chang
references.citation: Clin Cancer Res. 2001 Feb;7(2):243-54
references.pmid: 11234875
references.citation: Clin Cancer Res. 2002 Feb;8(2):413-8
references.pmid: 11839657
references.citation: Eur J Cancer. 2007 May;43(8):1242-50
references.pmid: 17449238
references.citation: Am J Pathol. 2009 Dec;175(6):2657-67
references.pmid: 19875502
references.citation: J Clin Oncol. 1995 Jul;13(7):1777-85
references.pmid: 7602367
references.citation: J Clin Oncol. 2006 Jun 1;24(16):2505-12
references.pmid: 16636341
references.citation: Cancer Cell. 2009 Dec 8;16(6):510-20
references.pmid: 19962669
references.citation: Eur J Cancer. 2001 Dec;37 Suppl 9:S15-8
references.pmid: 11741769
references.citation: Clin Cancer Res. 2000 May;6(5):1949-57
references.pmid: 10815920
references.citation: J Control Release. 2000 Mar 1;65(1-2):271-84
references.pmid: 10699287
references.citation: Clin Pharmacokinet. 2003;42(5):419-36
references.pmid: 12739982
references.citation: Br J Cancer. 2003 Jun 16;88(12):1979-86
references.pmid: 12799646
references.citation: EMBO J. 1994 May 1;13(9):2236-43
references.pmid: 7514533
references.citation: J Clin Pharmacol. 1996 Jan;36(1):55-63
references.pmid: 8932544
references.citation: Am J Pathol. 2000 Apr;156(4):1363-80
references.pmid: 10751361
references.citation: Science. 1995 Dec 8;270(5242):1657-60
references.pmid: 7502074
references.citation: Cancer Res. 2004 Nov 15;64(22):8249-55
references.pmid: 15548691
references.citation: PLoS One. 2009;4(1):e4171
references.pmid: 19137069
references.citation: N Engl J Med. 2004 Jun 3;350(23):2335-42
references.pmid: 15175435
references.citation: J Gen Virol. 2003 Oct;84(Pt 10):2771-2779
references.pmid: 13679612
references.citation: Curr Pharm Des. 2004;10(19):2335-43
references.pmid: 15279612
references.citation: Clin Cancer Res. 2002 Apr;8(4):1172-81
references.pmid: 11948130
references.citation: Nat Rev Cancer. 2002 Oct;2(10):750-63
references.pmid: 12360278
references.citation: J Control Release. 2010 Mar 3;142(2):167-73
references.pmid: 19861140
references.citation: Nat Med. 2002 Dec;8(12):1369-75
references.pmid: 12415261
references.citation: Nat Med. 1998 May;4(5):623-6
references.pmid: 9585240
references.citation: Nat Rev Cancer. 2004 Oct;4(10):806-13
references.pmid: 15510161
references.citation: Ann Oncol. 2000 Aug;11(8):1029-33
references.pmid: 11038041
references.citation: J Clin Invest. 2000 Apr;105(8):1045-7
references.pmid: 10772648
references.citation: Nat Biotechnol. 1997 Aug;15(8):772-7
references.pmid: 9255793
references.citation: Cancer Res. 2002 Feb 1;62(3):867-74
references.pmid: 11830545
references.citation: Cancer Res. 1987 Jun 15;47(12):3039-51
references.pmid: 3555767
references.citation: Science. 1998 Jan 16;279(5349):377-80
references.pmid: 9430587
references.citation: Science. 2005 Jan 7;307(5706):58-62
references.pmid: 15637262
references.citation: J Clin Invest. 2000 Apr;105(8):R15-24
references.pmid: 10772661
references.citation: Cancer Res. 1994 Jun 1;54(11):2830-3
references.pmid: 8187061
references.citation: Adv Drug Deliv Rev. 2004 Sep 22;56(11):1649-59
references.pmid: 15350294
references.citation: Cancer Res. 1986 Dec;46(12 Pt 1):6387-92
references.pmid: 2946403
references.citation: Science. 1995 Jul 14;269(5221):223-6
references.pmid: 7542403
references.citation: Biochemistry. 1997 Jan 7;36(1):66-75
references.pmid: 8993319
references.citation: J Control Release. 2009 Nov 3;139(3):174-81
references.pmid: 19576253
references.citation: Bioconjug Chem. 1997 Mar-Apr;8(2):111-8
references.pmid: 9095350
references.citation: Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11460-4
references.pmid: 1763060
references.citation: Clin Vaccine Immunol. 2007 Apr;14(4):404-11
references.pmid: 17287314
references.citation: Cancer Res. 2006 Oct 15;66(20):10073-82
references.pmid: 17047071
references.citation: Anal Biochem. 1966 Mar;14(3):328-36
references.pmid: 4161471
references.citation: Science. 2004 Mar 19;303(5665):1818-22
references.pmid: 15031496
references.citation: J Infect Dis. 2004 Aug 15;190(4):797-809
references.pmid: 15272409
references.citation: Cardiovasc Toxicol. 2007;7(2):72-4
references.pmid: 17652807
references.citation: Ann N Y Acad Sci. 1991;618:367-82
references.pmid: 2006796
references.citation: Br J Cancer. 1996 Oct;74(7):1023-9
references.pmid: 8855969
references.citation: Cancer Res. 2000 Feb 1;60(3):722-7
references.pmid: 10676659
references.citation: N Engl J Med. 2007 Jan 11;356(2):115-24
references.pmid: 17215529
references.citation: Nat Med. 2002 Feb;8(2):121-7
references.pmid: 11821895
references.citation: Pharmacol Rev. 1999 Dec;51(4):691-743
references.pmid: 10581328
references.citation: Cancer Res. 2007 Nov 15;67(22):10958-65
references.pmid: 18006841
references.citation: Cancer Res. 2002 Dec 15;62(24):7190-4
references.pmid: 12499256
references.citation: Br J Radiol. 1993 Mar;66(783):181-96
references.pmid: 7682469
references.citation: Cancer Res. 2004 Nov 1;64(21):8002-8
references.pmid: 15520208
references.citation: Cancer Res. 2002 Dec 1;62(23):6938-43
references.pmid: 12460910
references.citation: Clin Cancer Res. 2008 Nov 15;14(22):7320-9
references.pmid: 19010847
references.citation: Cancer Res. 2002 Oct 1;62(19):5476-84
references.pmid: 12359756
references.citation: J Clin Microbiol. 2001 Mar;39(3):977-82
references.pmid: 11230414
references.citation: Nat Med. 2004 Feb;10(2):145-7
references.pmid: 14745444
references.citation: Blood. 1999 Mar 1;93(5):1738-48
references.pmid: 10029604
references.citation: Br J Cancer. 2006 Jun 5;94(11):1615-20
references.pmid: 16685267
references.citation: J Biol Chem. 2009 May 8;284(19):12905-16
references.pmid: 19276080
references.citation: Mol Cancer Ther. 2008 Mar;7(3):579-89
references.pmid: 18347144
references.citation: Nat Rev Cancer. 2006 Sep;6(9):688-701
references.pmid: 16900224
references.citation: Cancer Res. 2001 Jun 15;61(12):4750-5
references.pmid: 11406547
references.citation: Clin Cancer Res. 2008 Mar 1;14(5):1310-6
references.pmid: 18316549
references.citation: Cancer Res. 2003 Nov 1;63(21):7400-9
references.pmid: 14612539
references.citation: Cancer Res. 1998 Mar 15;58(6):1195-201
references.pmid: 9515805
references.citation: Science. 2002 Jun 28;296(5577):2404-7
references.pmid: 12089446
references.citation: Cancer Res. 2000 Apr 1;60(7):1878-86
references.pmid: 10766175
references.citation: J Clin Oncol. 2007 Sep 1;25(25):3892-901
references.pmid: 17679727
references.citation: Science. 1997 Nov 7;278(5340):1125-8
references.pmid: 9353194
references.citation: Ann Oncol. 2004 Mar;15(3):517-25
references.pmid: 14998859
references.citation: Cancer Res. 2000 Dec 15;60(24):6942-9
references.pmid: 11156394
references.citation: Cancer. 1995 Apr 15;75(8):2169-73
references.pmid: 7697608
references.citation: Oncology (Williston Park). 2005 Apr;19(4 Suppl 3):7-16
references.pmid: 15934498