title: The mucosal immune response to plant-derived vaccines.
abstract: Transgenic plants present enormous potential as one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary and agricultural uses. Heat-stable plant-derived vaccines that are administered orally could in effect enhance vaccine coverage in children and infants, particularly in developing countries. Here we discuss the current status of plant-derived vaccines and their potential to champion the battle against infectious diseases in the least developed countries.
authors.affiliation: Cornell Research Foundation, Cornell University, 395 Pine Tree Rd Suite 310, Ithaca, NY 14850, USA. klh22@cornell.edu
authors.forename: Kathleen Laura
authors.initials: KL
authors.lastname: Hefferon
mesh_terms: D001709:Biotechnology / Q000379:methods*; D003141:Communicable Diseases / Q000276:immunology; D003906:Developing Countries; D006801:Humans; D018928:Immunity, Mucosal; D046549:Plantibodies / Q000276:immunology*; D030821:Plants, Genetically Modified / Q000378:metabolism*; D022462:Vaccines, Edible / Q000096:biosynthesis / Q000276:immunology; D014614:Vaccines, Synthetic / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D046549:Plantibodies; D022462:Vaccines, Edible; D014614:Vaccines, Synthetic
references.citation: Plant Biotechnol J. 2009 Jan;7(1):59-72
references.pmid: 18793269
references.citation: Expert Rev Vaccines. 2006 Apr;5(2):249-60
references.pmid: 16608424
references.citation: J Agric Food Chem. 2006 Dec 27;54(26):9901-5
references.pmid: 17177518
references.citation: Biotechnol Prog. 2005 May-Jun;21(3):728-34
references.pmid: 15932249
references.citation: Curr Top Microbiol Immunol. 2009;332:103-17
references.pmid: 19401823
references.citation: Curr Opin Struct Biol. 2006 Oct;16(5):576-83
references.pmid: 16963259
references.citation: Environ Health Perspect. 2007 Mar;115(3):354-60
references.pmid: 17431483
references.citation: Virus Res. 2005 Jul;111(1):93-100
references.pmid: 15896408
references.citation: J Immunol. 2003 Aug 15;171(4):2116-26
references.pmid: 12902518
references.citation: FASEB J. 2006 May;20(7):959-61
references.pmid: 16603603