Steroidal alkaloids of Veratrum lobelianum Bernh. and Veratrum nigrum L.
Twelve steroidal alkaloids were isolated from four populations of Veratrum lobelianum Bernh. and Veratrum nigrum L. Full NMR data for veralosinine (1), and extensive 1H NMR data for veralosine (3) and teinemine (5) are presented here for the first time. (+/-)-15-O-(2-Methylbutyroyl)germine (10) is undescribed up to now. The antiproliferative activities of veranigrine, veralosinine, and neogermitrine have shown that they are a perspective for further studies.
Christov
Veselin
V
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. christov@orgchm.bas.bg
Mikhova
Bozhanka
B
Ivanova
Antoaneta
A
Serly
Julianna
J
Molnar
Joseph
J
Selenge
Dangaa
D
Solongo
Amgalan
A
Kostova
Nadezhda
N
Gerelt-Od
Yadamsuren
Y
Dimitrov
Dimitar
D
D000818:Animals; D002031:Bulgaria; D002455:Cell Division / Q000187:drug effects*; D007940:Leukemia L5178 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D051379:Mice; D008958:Models, Molecular; D008986:Mongolia; D010840:Phytosterols / Q000494:pharmacology; D014703:Veratrum / Q000737:chemistry*; D014704:Veratrum Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D010840:Phytosterols; D014704:Veratrum Alkaloids; C539652:veranigrine