[Function of endothelium and feto-utero-placental blood flow in pregnant women with arterial hypertension].
Aim of the study was to investigate function of endothelium and utero feto placental blood flow in pregnant women with various degree of arterial hypertension as well as effect of nifedipine SR/GITS and bisoprolol on arterial pressure level, brachial artery endothelium dependent vasodilation (EDVD), level of von Willebrand factor (FW) and resistance index, characterizing the state of utero feto placental blood flow. Examination and treatment for 4 weeks with nifedipine SR/GITS and bisoprolol (more often in combination) was carried out in 47 pregnant women with stage II hypertension during trimester II of gestation. At baseline we found significant lowering of EDVD progressing with elevation of degree of hypertension, elevation of FW level and resistance index in umbilical arteries. In dynamics at the background of treatment parallel with normalization of arterial pressure we noted significant improvement of endothelial function manifested by elevation of EDVD and lowering of FW level, as well as elevation of blood flow in arteries of umbilical cord.
Striuk
R I
RI
Moscow State Medical Dental University, ul. Delegatskaya 20/1, 127473 Moscow, Russia. rstryuk@list.ru
Bukhonkina
Iu M
IuM
Smirnova
V A
VA
Chizhova
G V
GV
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001916:Brachial Artery / Q000503:physiopathology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D021041:Placental Circulation / Q000502:physiology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D012307:Risk Factors; D014655:Vascular Resistance / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*; D055815:Young Adult