Ornithine decarboxylase G316A genotype and colorectal cancer risk.
OBJECTIVE
Ornithine decarboxylase (ODC) is a modifier of adenomatous polyposis coli-dependent tumourigenesis. The G316 > A polymorphism in intron 1 of the ODC gene lies between two myc-binding domains and alters the expression of the gene to affect polyamine metabolism. This variant may be associated with recurrence of colorectal adenoma. We examined whether this variant also modified the susceptibility to sporadic colorectal cancer (CRC).


METHODS
The G316 > A variant was analysed in a large (n = 754) CRC case-controlled series of hospital patient volunteers (n = 627) in the Czech Republic, and the relationship with cancer risk was estimated by conditional logistic regression.


RESULTS
After adjusting for age and sex, G316 > A was associated with no decrease in CRC risk for either heterozygotes [odds ratio 0.98, 95% confidence interval (CI) 0.77-1.23] or rare allele homozygotes (odds ratio 0.92, 95% CI 0.61-1.37).


CONCLUSIONS
The G316 > A functional variant in the ODC gene is unlikely to make much impact on reducing CRC risk regardless of the reduction in risk found for the recurrence of colorectal adenoma.
Hughes
D J
DJ
Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide & Meath Hospital, Dublin, Ireland. hughesd4@tcd.ie
Hlavatá
I
I
Soucek
P
P
Pardini
B
B
Naccarati
A
A
Vodickova
L
L
O'Morain
C
C
Vodicka
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000235:genetics*; D018153:Czech Republic; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012004:Rectal Neoplasms / Q000235:genetics*
D009955:Ornithine Decarboxylase