Biomechanics in bone tissue engineering.
Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach; so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally, the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesised and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects of bone tissue engineering: the former could be related to osteoconduction, while the latter may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets but also incorporating some mechanotransduction principles.
Pioletti
Dominique P
DP
Laboratory of Biomechanical Orthopedics, EPFL, Lausanne, Switzerland. dominique.pioletti@epfl.ch
D001696:Biomechanical Phenomena; D001842:Bone and Bones; D006801:Humans; D008954:Models, Biological; D023822:Tissue Engineering