Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia.
Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.
Novak
Gabriela
G
Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8.
LeBlanc
Martha
M
Zai
Clement
C
Shaikh
Sajid
S
Renou
Julien
J
DeLuca
Vincenzo
V
Bulgin
Natalie
N
Kennedy
James L
JL
Le Foll
Bernard
B
D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*; D012907:Smoking / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor; C493593:DRD3 protein, human; D017447:Receptors, Dopamine D1; D050637:Receptors, Dopamine D3