Boiling water-catalyzed neutral and selective N-Boc deprotection.
A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.
Wang
Jia
J
State key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Liang
Yan-Liang
YL
Qu
Jin
J
D002384:Catalysis; D005563:Formic Acid Esters / Q000737:chemistry*; D006358:Hot Temperature; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D005563:Formic Acid Esters; C000345:t-butyloxycarbonyl group; D014867:Water