title: Rosaceiform dermatitis associated with topical tacrolimus treatment.
abstract: We describe herein 3 patients who developed rosacea-like dermatitis eruptions while using 0.03% or 0.1% tacrolimus ointment for facial dermatitis. Skin biopsy specimens showed telangiectasia and noncaseating epithelioid granulomatous tissue formation in the papillary to mid dermis. Continuous topical use of immunomodulators such as tacrolimus or pimecrolimus should be regarded as a potential cause of rosaceiform dermatitis, although many cases have not been reported.
authors.affiliation: Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Yukari
authors.initials: Y
authors.lastname: Okubo
authors.forename: Ryokichi
authors.initials: R
authors.lastname: Irisawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tsuboi
mesh_terms: D000287:Administration, Topical; D000368:Aged; D005148:Facial Dermatoses / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012393:Rosacea / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects*; D013684:Telangiectasis / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus