[Current problems in the prevention and treatment of infections in patients with cirrhosis].
Infections in patients with cirrhosis are a common complication causing substantial morbidity and mortality. Bacterial translocation plays an important role in the pathogenesis of many infections in cirrhosis. In turn, infections are involved in the pathogenesis of many episodes of decompensated cirrhosis, such as esophageal variceal bleeding, renal insufficiency, the hemodynamic alterations of cirrhosis, and hepatic encephalopathy. Spontaneous bacterial peritonitis is currently the most frequent infection in cirrhosis. Mortality from this entity has recently decreased due to early diagnosis, the use of appropriate antibiotic therapy, and albumin administration. However, infections due to multiresistant microorganisms have recently increased, leading to greater mortality. Primary prophylaxis with quinolones is effective in preventing infections and is associated with lower mortality in a selected population of patients with liver cirrhosis.
Bellot
Pablo
P
Unidad Hepática, Hospital General y Universitario de Alicante, Alicante España.
Jara Pérez López
Neftalí
N
Martínez Moreno
Belén
B
Such
José
J
D058186:Acute Kidney Injury / Q000209:etiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D018988:Bacterial Translocation; D001778:Blood Coagulation Disorders / Q000209:etiology; D024901:Drug Resistance, Multiple, Bacterial; D042241:Early Diagnosis; D004932:Esophageal and Gastric Varices / Q000209:etiology; D024841:Fluoroquinolones / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006501:Hepatic Encephalopathy / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D017053:Infection Control; D008103:Liver Cirrhosis / Q000150:complications* / Q000276:immunology; D009928:Organ Specificity; D010538:Peritonitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D018805:Sepsis / Q000209:etiology; D012709:Serum Albumin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D012709:Serum Albumin