Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.
A recent pediatric-focused genome-wide association study has implicated three novel susceptibility loci for Crohn' disease (CD).We aimed to investigate whether the three recently reported and other previously reported genes/loci were also associated with CD in Canadian children. A case-control design was implemented at three pediatric gastroenterology clinics in Canada. Children <19 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in 19 reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. A total of 563 cases and 553 controls were studied. The mean (+/-SD) age of the cases was 12.3 (+/-3.2) years. Most cases were male (56.0%), had ileo-colonic disease (L3 +/- L4, 48.8%) and inflammatory behavior (B1 +/- p, 87.9%) at diagnosis. Allelic association analysis (two-tailed) showed that 8 of the 19 targeted SNPs were significantly associated with overall susceptibility for CD. Associations with one additional SNP was borderline non-significant. Significantly associated SNPs included SNPs rs1250550 (p = 0.026) and rs8049439 (p = 0.04), recently reported to be specifically associated with pediatric-onset CD.Based on the results, we confirmed associations between two of the three novel pediatric-CD loci and other regions reported for associations with either pediatric and/or adult-onset CD.
Amre
Devendra K
DK
Department of Pediatrics, University of Montreal, Montreal, QC, Canada. devendra.amre@umontreal.ca
Mack
David R
DR
Morgan
Kenneth
K
Israel
David
D
Deslandres
Colette
C
Seidman
Ernest G
EG
Lambrette
Phlippe
P
Costea
Irina
I
Krupoves
Alfreda
A
Fegury
Houda
H
Dong
Jinsong
J
Xhu
Zia
Z
Grimard
Guy
G
Levy
Emile
E
D000328:Adult; D000483:Alleles; D002170:Canada; D002648:Child; D003424:Crohn Disease / Q000175:diagnosis / Q000235:genetics*; D016678:Genome; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012106:Research
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