[Some features of immunological status in young peoples irradiated in utero or in age up to 4 years as result of Chernobyl accident].
Some characteristics of immune system, namely quantities of serum immunoglobulins A, G, M and activity of free and hidden autoantibodies to DNA, cardiolipin and microsomal thyroid antigen were studied in young people irradiated in utero or in age up to 4 years through Chernobyl accident. The hallmarker of observed immunological changes is low content of immunoglobulin A. Degree of reduction was in back proportion with level 137Cs contamination inhabit territory. A lowering of the content of IgA in persons irradiated in utero depends on period of pregnancy at a moment of the accident: the most reduction was observed in young people irradiated in the first trimester of gestation. It was shown elevation of activity autoantibodies to cardiolipin. Both deficit of IgA and elevation activity the autoantibodies were observed only in proportion of young people irradiated in utero or in early period of life.
Pal'okha
E A
EA
Saenko
A S
AS
Lekakh
I V
IV
Leonova
O
O
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood / Q000528:radiation effects; D002308:Cardiolipins / Q000276:immunology; D002588:Cesium Radioisotopes / Q000633:toxicity; D047852:Chernobyl Nuclear Accident; D004247:DNA / Q000276:immunology; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000528:radiation effects; D008861:Microsomes / Q000276:immunology; D011247:Pregnancy; D011832:Radiation Injuries / Q000097:blood / Q000276:immunology*; D011848:Radioactive Pollutants / Q000633:toxicity; D012426:Russia; D013961:Thyroid Gland / Q000276:immunology; D055815:Young Adult
D001323:Autoantibodies; D002308:Cardiolipins; D002588:Cesium Radioisotopes; D007070:Immunoglobulin A; D011848:Radioactive Pollutants; D004247:DNA