Looking for a 5-HT7 radiotracer for positron emission tomography.
In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation.
Andriès
Julien
J
Université de Lyon, Université Lyon 1, CNRS, ICBMS (UMR CNRS 5246), Lyon, France.
Lemoine
Laëtitia
L
Mouchel-Blaisot
Alice
A
Tang
Sandrine
S
Verdurand
Mathieu
M
Le Bars
Didier
D
Zimmer
Luc
L
Billard
Thierry
T
D000818:Animals; D001345:Autoradiography; D001565:Benzoates / Q000737:chemistry / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D005462:Fluorine Radioisotopes; D057927:Hydrophobic and Hydrophilic Interactions; D007553:Isotope Labeling; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis*
D001565:Benzoates; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor; C022893:4-fluorobenzoic acid