title: Hepatitis C virus: assembly and release of virus particles.
abstract: Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny. Thus, it is now possible to gain insight into the roles played by viral components in assembly and egress and the cellular pathways that contribute to virion formation. This minireview describes the key determining viral and host factors that are needed to produce infectious virus.
authors.affiliation: Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Jones
authors.forename: John
authors.initials: J
authors.lastname: McLauchlan
mesh_terms: D016174:Hepacivirus / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014771:Virion / Q000737:chemistry / Q000378:metabolism*; D019065:Virus Assembly; D057074:Virus Release
chemical_list: D014764:Viral Proteins
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