title: Isometric quadriceps strength in women with mild, moderate, and severe knee osteoarthritis.
abstract: OBJECTIVE
  Quadriceps weakness is a common clinical sign in persons with moderate-to-severe osteoarthritis and results in physical disability; however, minimal data exist to establish whether quadriceps weakness is present in early stages of the disease. Therefore, our purpose was to determine whether quadriceps weakness was present in persons with early radiographic and cartilaginous evidence of osteoarthritis. Further, we sought to determine whether quadriceps strength decreases as osteoarthritis severity increases.
  
  
  METHODS
  Three hundred forty-eight women completed radiologic and magnetic resonance imaging evaluation, in addition to strength testing. Anterior-posterior radiographs were graded for tibiofemoral osteoarthritis severity using the Kellgren-Lawrence scale. Scans from magnetic resonance imaging were used to assess medial tibiofemoral and patellar cartilage based on a modification of the Noyes scale. The peak knee extension torque recorded was used to represent strength.
  
  
  RESULTS
  Quadriceps strength (Nm/kg) was 22% greater in women without radiographic osteoarthritis than in women with osteoarthritis (P < 0.05). Quadriceps strength was also greater in women with Noyes' medial tibial and femoral cartilage scores of 0 when compared in women with Noyes' grades 2 and 3-5 (P < or = 0.05).
  
  
  CONCLUSIONS
  Women with early evidence of osteoarthritis had less quadriceps strength than women without osteoarthritis as defined by imaging.
authors.affiliation: University of Michigan, Ann Arbor, 48109, USA.
authors.forename: Riann M
authors.initials: RM
authors.lastname: Palmieri-Smith
authors.forename: Abbey C
authors.initials: AC
authors.lastname: Thomas
authors.forename: Carrie
authors.initials: C
authors.lastname: Karvonen-Gutierrez
authors.forename: Mary Fran
authors.initials: MF
authors.lastname: Sowers
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018908:Muscle Weakness / Q000175:diagnosis*; D020370:Osteoarthritis, Knee / Q000175:diagnosis*; D010147:Pain Measurement; D011336:Probability; D011379:Prognosis; D052097:Quadriceps Muscle / Q000000981:diagnostic imaging* / Q000473:pathology*; D016059:Range of Motion, Articular / Q000502:physiology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods
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