title: Age-related hearing loss or presbycusis.
abstract: Aging is a natural consequence of a society developing process. Although many adults retain good hearing as they aging, hearing loss related with age-presbycusis which can vary in severity from mild to substantial is common among elderly persons. There are a number of pathophysiological processes underlying age-related changes in the auditory system as well as in the central nervous systems. Many studies have been dedicated to the illustration of risk factors accumulating presbycusis such as heritability, environment factors, medical conditions, free radical (reactive oxygen species, ROS) and damage of mitochondrial DNA. Left untreated, presbycusis can not only lead sufferers to reduced quality of life, isolation, dependence and frustration, but also affect the healthy people around. These can be partly corrected using hearing aids, but it is not enough, more and more strategies of treatment based on the findings associating with presbycusis should be added rather than using single hearing aids. We review here the pathophysiology; heritability, susceptibility genes and other risk factors including environmental, medical, especially free radical (ROS) and damage of mitochondrial DNA; and some strategies of treatment, as well as promising rehabilitations associating with presbycusis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways / Q000503:physiopathology; D017626:Cochlear Nucleus / Q000503:physiopathology; D003142:Communication; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005829:Geniculate Bodies / Q000503:physiopathology; D006310:Hearing Aids; D006801:Humans; D011304:Presbycusis / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000534:rehabilitation; D011788:Quality of Life / Q000523:psychology; D012307:Risk Factors; D055815:Young Adult
references.citation: Hear Res. 2007 Apr;226(1-2):194-202
references.pmid: 16843623
references.citation: Hum Mol Genet. 2008 Jan 15;17(2):159-69
references.pmid: 17921507
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12523-8
references.pmid: 16888038
references.citation: Nat Med. 2003 Oct;9(10):1293-9
references.pmid: 12949502
references.citation: Audiol Neurootol. 2007;12(3):145-54
references.pmid: 17259700
references.citation: Braz J Otorhinolaryngol. 2009 Jul-Aug;75(4):573-8
references.pmid: 19784428
references.citation: Lancet. 2005 Sep 24-30;366(9491):1111-20
references.pmid: 16182900
references.citation: Prev Med. 2005 Feb;40(2):138-44
references.pmid: 15533522
references.citation: Nat Med. 2005 Mar;11(3):271-6
references.pmid: 15711559
references.citation: J Neurosci. 2003 Jul 9;23(14):6111-22
references.pmid: 12853430
references.citation: Ann N Y Acad Sci. 2002 Apr;959:508-16
references.pmid: 11976223
references.citation: Nature. 2007 Sep 6;449(7158):87-91
references.pmid: 17805295
references.citation: Nat Cell Biol. 2003 May;5(5):422-6
references.pmid: 12717441
references.citation: Hum Mutat. 2006 Oct;27(10):1007-16
references.pmid: 16917933
references.citation: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4084-8
references.pmid: 10097167
references.citation: Acta Otolaryngol. 2004 Mar;124(2):130-6
references.pmid: 15072414
references.citation: J Acoust Soc Am. 1990 Aug;88(2):813-20
references.pmid: 2212307
references.citation: Behav Brain Res. 2005 Jan 6;156(1):95-103
references.pmid: 15474654
references.citation: Genomics. 2000 Dec 1;70(2):171-80
references.pmid: 11112345
references.citation: J Acoust Soc Am. 2006 Feb;119(2):1143-55
references.pmid: 16521775
references.citation: Hear Res. 1997 Aug;110(1-2):147-54
references.pmid: 9282897
references.citation: J Occup Med. 1989 Dec;31(12):996
references.pmid: 2614541
references.citation: Am J Otol. 1988 Sep;9(5):376-82
references.pmid: 3202126
references.citation: Dev Biol. 2005 Apr 15;280(2):281-94
references.pmid: 15882573
references.citation: Hear Res. 2005 Nov;209(1-2):10-8
references.pmid: 16039078
references.citation: Postgrad Med J. 2006 Mar;82(965):166-71
references.pmid: 16517797
references.citation: J Am Acad Audiol. 2008 Apr;19(4):281-92; quiz 371
references.pmid: 18795468
references.citation: Arch Otolaryngol Head Neck Surg. 1999 Jun;125(6):654-9
references.pmid: 10367922
references.citation: Ear Hear. 2008 Aug;29(4):578-84
references.pmid: 18469720
references.citation: Curr Pharm Des. 2007;13(1):119-26
references.pmid: 17266591
references.citation: Acta Otolaryngol. 2001 Sep;121(6):666-72
references.pmid: 11678164
references.citation: Acta Otolaryngol. 1991;111(2):240-8
references.pmid: 2068909
references.citation: J Acoust Soc Am. 1991 Jul;90(1):175-81
references.pmid: 1880286
references.citation: Development. 2005 May;132(10):2377-88
references.pmid: 15843406
references.citation: Laryngoscope. 2009 Jun;119(6):1180-3
references.pmid: 19301411
references.citation: Laryngoscope. 2001 Mar;111(3):528-34
references.pmid: 11224787
references.citation: Arch Med Res. 2009 Jan;40(1):18-23
references.pmid: 19064122
references.citation: Ann Otol Rhinol Laryngol. 1993 Jan;102(1 Pt 2):1-16
references.pmid: 8420477
references.citation: Mutat Res. 2008 Apr 2;640(1-2):38-45
references.pmid: 18242646
references.citation: Lancet. 1986 Jan 18;1(8473):121-3
references.pmid: 2867347
references.citation: Scand Audiol. 1997;26(3):133-40
references.pmid: 9309808
references.citation: Arch Otolaryngol Head Neck Surg. 2007 Sep;133(9):929-33
references.pmid: 17875861
references.citation: Apoptosis. 2008 Nov;13(11):1303-21
references.pmid: 18839313
references.citation: Arch Otolaryngol Head Neck Surg. 2006 May;132(5):506-10
references.pmid: 16702566
references.citation: Prev Med. 2007 Feb;44(2):124-8
references.pmid: 17157369
references.citation: J Acoust Soc Am. 1988 Mar;83(3):859-95
references.pmid: 3281988
references.citation: Clin Otolaryngol. 2006 Apr;31(2):116-22
references.pmid: 16620330
references.citation: Acta Otolaryngol. 2009 Jan;129(1):36-44
references.pmid: 18607930
references.citation: Acta Otolaryngol Suppl. 1990;476:54-68
references.pmid: 2087980
references.citation: J Assoc Res Otolaryngol. 2005 Sep;6(3):234-43
references.pmid: 15983726
references.citation: Acta Otolaryngol Suppl. 2004 Mar;(551):26-30
references.pmid: 15078073
references.citation: Hear Res. 1990 Jun;46(1-2):113-45
references.pmid: 2380120
references.citation: Int J Audiol. 2006 Jul;45(7):367-81
references.pmid: 16938795
references.citation: J Gerontol. 1985 Sep;40(5):579-85
references.pmid: 4031406
references.citation: J Pathol. 2007 Jan;211(2):188-97
references.pmid: 17200945
references.citation: Ageing Res Rev. 2002 Jun;1(3):331-43
references.pmid: 12067590
references.citation: Methods Mol Biol. 2006;330:71-92
references.pmid: 16846017
references.citation: Acta Otolaryngol. 2006 Jan;126(1):10-4
references.pmid: 16308248
references.citation: Mol Ther. 2002 Jul;6(1):12-8
references.pmid: 12095298
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2004 Oct;12(5):439-43
references.pmid: 15377958
references.citation: J Assoc Res Otolaryngol. 2003 Sep;4(3):353-62
references.pmid: 14690053
references.citation: Hear Res. 1998 Apr;118(1-2):101-13
references.pmid: 9606065
references.citation: Physiol Rev. 1998 Apr;78(2):547-81
references.pmid: 9562038
references.citation: Zhonghua Yi Xue Za Zhi. 2003 Sep 10;83(17):1517-20
references.pmid: 14521734
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4333-8
references.pmid: 10760300
references.citation: Hear Res. 1997 Dec;114(1-2):75-82
references.pmid: 9447921
references.citation: Otol Neurotol. 2004 May;25(3):298-301
references.pmid: 15129109
references.citation: Ann Intern Med. 1990 Aug 1;113(3):188-94
references.pmid: 2197909
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7
references.pmid: 19901338
references.citation: Audiology. 2001 Nov-Dec;40(6):313-21
references.pmid: 11781044
references.citation: Hear Res. 2010 Jun 1;264(1-2):98-107
references.pmid: 19735708
references.citation: Arch Otolaryngol Head Neck Surg. 2003 Oct;129(10):1041-6
references.pmid: 14568784
references.citation: Brain Res. 2006 May 26;1091(1):89-102
references.pmid: 16631134
references.citation: Acta Otolaryngol. 2001 Jan;121(2):140-2
references.pmid: 11349765
references.citation: Gerontology. 2010;56(2):123-8
references.pmid: 19713692
references.citation: Hear Res. 2010 Jun 1;264(1-2):41-7
references.pmid: 19931608
references.citation: Acta Otolaryngol Suppl. 2004 May;(552):16-24
references.pmid: 15219042
references.citation: J Assoc Res Otolaryngol. 2002 Dec;3(4):444-56
references.pmid: 12486599
references.citation: Exp Gerontol. 2003 Jan-Feb;38(1-2):87-94
references.pmid: 12543265
references.citation: J Am Geriatr Soc. 2005 Dec;53(12):2119-27
references.pmid: 16398896
references.citation: Laryngoscope. 2009 Jun;119(6):1184-9
references.pmid: 19358252
references.citation: Exp Gerontol. 2003 Mar;38(3):319-25
references.pmid: 12581797
references.citation: Audiol Neurootol. 2007;12(6):345-58
references.pmid: 17664866
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13495-500
references.pmid: 14593207
references.citation: Ear Hear. 1997 Apr;18(2):114-20
references.pmid: 9099560
references.citation: Am J Otol. 1997 Jul;18(4):449-53
references.pmid: 9233484
references.citation: J Public Health Med. 2000 Dec;22(4):512-7
references.pmid: 11192279
references.citation: J Speech Lang Hear Res. 2005 Apr;48(2):473-81
references.pmid: 15989405
references.citation: Biochem Biophys Res Commun. 2007 Mar 30;355(1):117-21
references.pmid: 17291455
references.citation: Int J Audiol. 2003 Jul;42 Suppl 2:2S3-10
references.pmid: 12918622
references.citation: Hear Res. 2007 Apr;226(1-2):185-93
references.pmid: 16870370
references.citation: Hear Res. 2000 Mar;141(1-2):220-8
references.pmid: 10713509
references.citation: Acta Otolaryngol. 2005 Dec;125(12):1272-6
references.pmid: 16303673
references.citation: Science. 2005 Jul 15;309(5733):481-4
references.pmid: 16020738
references.citation: Nat Genet. 2003 Sep;35(1):21-3
references.pmid: 12910270
references.citation: Cell. 1999 Feb 5;96(3):437-46
references.pmid: 10025409
references.citation: Arch Phys Med Rehabil. 2006 Jun;87(6):757-63
references.pmid: 16731209
references.citation: J Otolaryngol Head Neck Surg. 2008 Aug;37(4):488-94
references.pmid: 19128581
references.citation: Int J Audiol. 2003 Jul;42 Suppl 2:2S92-101
references.pmid: 12918635
references.citation: Hear Res. 1990 Jul;46(3):201-10
references.pmid: 2394633
references.citation: J Acoust Soc Am. 2005 Aug;118(2):1089-100
references.pmid: 16158663
references.citation: Ear Hear. 2006 Jun;27(3):263-78
references.pmid: 16672795
references.citation: Hear Res. 2007 Apr;226(1-2):157-67
references.pmid: 17113254
references.citation: Arch Otolaryngol Head Neck Surg. 1997 Oct;123(10):1039-45
references.pmid: 9339978
references.citation: Arch Otolaryngol. 1964 Oct;80:369-82
references.pmid: 14198699
references.citation: JAMA. 2002 Nov 13;288(18):2271-81
references.pmid: 12425704
references.citation: Arch Neurol. 1995 Jun;52(6):626-34
references.pmid: 7763213
references.citation: Arch Otolaryngol Head Neck Surg. 2003 Mar;129(3):285-9
references.pmid: 12622536
references.citation: Osteoporos Int. 2005 Dec;16(12):1675-82
references.pmid: 15883660
references.citation: J Am Acad Audiol. 1997 Aug;8(4):269-76
references.pmid: 9272749
references.citation: J Neurosci. 2001 Jul 1;21(13):4712-20
references.pmid: 11425898
references.citation: Mol Ther. 2001 Jun;3(6):958-63
references.pmid: 11407910
references.citation: J Commun Disord. 2007 Jul-Aug;40(4):305-12
references.pmid: 17433356
references.citation: J Acoust Soc Am. 1998 Oct;104(4):2385-99
references.pmid: 10491702
references.citation: Nature. 2004 May 27;429(6990):417-23
references.pmid: 15164064
references.citation: Hear Res. 1997 Dec;114(1-2):83-92
references.pmid: 9447922
references.citation: Neurobiol Aging. 2007 Oct;28(10):1605-12
references.pmid: 16920227
references.citation: Ear Hear. 1990 Aug;11(4):247-56
references.pmid: 2210098
references.citation: Laryngoscope. 2005 Dec;115(12):2238-41
references.pmid: 16369173
references.citation: Genomics. 2002 Nov;80(5):461-4
references.pmid: 12408962
references.citation: Biochem Biophys Res Commun. 2004 Nov 26;324(4):1283-8
references.pmid: 15504353