Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics.
Toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine are diaminotoluenes used as colorants in permanent hair dyes and tints. Toluene-2,5-diamine is used in 79 products at concentrations up to 3%; toluene-2,5-diamine sulfate is used in 168 products at concentrations up to 4%. Toluene-3,4-diamine does not appear to be in current use. Previously, the Cosmetic Ingredient Review Expert Panel determined that all 3 ingredients were safe for use as hair dyes. New data suggest that differences in toxicity, especially with respect to carcinogenicity, may exist as a function of placement of amine groups around the benzene ring. The Expert Panel concluded that toluene-2,5-diamine and toluene-2,5-diamine sulfate and are safe as hair dye ingredients in the present practices of use and concentrations but that there are insufficient data supporting the safety of toluene-3,4-diamine.
Burnett
Christina L
CL
Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. cirinfo@cir-safety.org
Bergfeld
Wilma F
WF
Belsito
Donald V
DV
Klaassen
Curtis D
CD
Marks
James G
JG
Shank
Ronald C
RC
Slaga
Thomas J
TJ
Snyder
Paul W
PW
Alan Andersen
F
F
D000818:Animals; D000830:Animals, Laboratory; D003257:Consumer Product Safety; D005260:Female; D006202:Hair Dyes / Q000633:toxicity*; D006801:Humans; D008297:Male; D010655:Phenylenediamines / Q000737:chemistry / Q000633:toxicity*; D018570:Risk Assessment
D006202:Hair Dyes; D010655:Phenylenediamines; C007303:2,5-diaminotoluene; C011131:3,4-toluenediamine