title: BiliChek transcutaneous bilirubin meter overestimates serum bilirubin as measured by the Doumas reference method.
abstract: OBJECTIVE
  To determine the relationship between BiliChek TcB (Respironics, Marietta GA) and Doumas reference serum or plasma total bilirubin (TSB).
  
  
  METHODS
  Pooled samples with values assigned by the Doumas reference method were used to establish the relationship between a local laboratory and reference Doumas TSB. We then established the relationship between TcB and TSB in the 3 months before and after reassignment of calibrator setpoints undertaken to match the local laboratory to Doumas reference bilirubin values.
  
  
  RESULTS
  Before calibrator setpoint reassignment TSB as measured in our laboratory overestimated Doumas reference bilirubin. After calibrator adjustment laboratory TSB was within 1.7-6.8 micromol/L (0.1-0.4 mg/dL) of Doumas reference values. Mean bias between BiliChek TcB and TSB was 42.8+/-22.2 micromol/L (2.5+/-1.3mg/dL) (n=94) before and 49.6+/-22.2 micromol/L (2.9+/-1.3mg/dL) (n=115) after calibration adjustment.
  
  
  CONCLUSIONS
  BiliChek TcB significantly overestimates TSB as measured by the Doumas reference method.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Karon.bradley@mayo.edu
authors.forename: Brad S
authors.initials: BS
authors.lastname: Karon
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Wickremasinghe
authors.forename: Stanley F
authors.initials: SF
authors.lastname: Lo
authors.forename: Amy K
authors.initials: AK
authors.lastname: Saenger
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Cook
mesh_terms: D001663:Bilirubin / Q000097:blood*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000175:diagnosis; D007231:Infant, Newborn; D015997:Neonatal Screening / Q000379:methods*
chemical_list: D001663:Bilirubin