title: Neutralising antibody responses in cattle and sheep following booster vaccination with two commercial inactivated bluetongue virus serotype 8 vaccines.
abstract: Cattle and sheep that had received a primary course of vaccination with an inactivated bluetongue virus serotype 8 (BTV-8) vaccine were booster vaccinated 6 or 12 months later with the homologous vaccine or an alternative inactivated BTV-8 vaccine and neutralising antibody responses were determined. Antibody titres to the alternative vaccine were significantly higher than to the homologous vaccine (P=0.013) in cattle. There was no significant difference between the antibody responses to alternative and homologous vaccines in sheep. These data indicate that cattle and sheep primed with one inactivated BTV-8 vaccine may be effectively boosted with an alternative commercial inactivated BTV-8 vaccine.
authors.affiliation: Fort Dodge Animal Health, Hedge End, Southampton SO30 4QH, UK. david.bartram@pfizer.com
authors.forename: David J
authors.initials: DJ
authors.lastname: Bartram
authors.forename: Lindsay
authors.initials: L
authors.lastname: Heasman
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Batten
authors.forename: Christopher A L
authors.initials: CA
authors.lastname: Oura
authors.forename: Joan
authors.initials: J
authors.lastname: Plana-Durán
authors.forename: Ho Ming
authors.initials: HM
authors.lastname: Yuen
authors.forename: Andrew D M
authors.initials: AD
authors.lastname: Wylie
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood* / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D001819:Bluetongue / Q000276:immunology / Q000517:prevention & control*; D001820:Bluetongue virus / Q000276:immunology*; D002417:Cattle; D005260:Female; D007117:Immunization, Secondary / Q000662:veterinary*; D008297:Male; D012756:Sheep; D015164:Vaccines, Inactivated; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines