title: Sickle cell disease and the eye: old and new concepts.
abstract: The pathophysiology of sickle cell disease is not limited to abnormal red blood cells. The clinical manifestations of sickle cell disease include complex pathways and processes such as endothelial activation, inflammation, bioavailability of nitric oxide, oxidative stress, and the adhesiveness of a variety of blood cells. Increasingly, distinct subphenotypes and genetic modifiers of sickle cell disease are being recognized. We apply recent advances in sickle cell disease to ocular biology to highlight translational research in this field and encourage additional studies on the ocular manifestations of sickle cell disease.
authors.affiliation: Laser and Retinal Research Unit, Department of Ophthalmology, King's College Hospital, Denmark Hill, London, United Kingdom.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Elagouz
authors.forename: Sreedhar
authors.initials: S
authors.lastname: Jyothi
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Gupta
authors.forename: Sobha
authors.initials: S
authors.lastname: Sivaprasad
mesh_terms: D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000503:physiopathology*; D006801:Humans