Three-dimensional, multiwavelength Monte Carlo simulations of dermally implantable luminescent sensors.
Dermally implanted luminescent sensors have been proposed for monitoring of tissue biochemistry, which has the potential to improve treatments for conditions such as diabetes and kidney failure. Effective in vivo monitoring via noninvasive transdermal measurement of emission from injected microparticles requires a matched optoelectronic system for excitation and collection of luminescence. We applied Monte Carlo modeling to predict the characteristics of output luminescence from microparticles in skin to facilitate hardware design. Three-dimensional, multiwavelength Monte Carlo simulations were used to determine the spatial and spectral distribution of the escaping luminescence for different implantation depths, excitation light source properties, particle characteristics, and particle packing density. Results indicate that the ratio of output emission to input excitation power ranged 10(-3) to 10(-6) for sensors at the upper and lower dermal boundaries, respectively, and 95% of the escaping emission photons induced by a 10-mm-diam excitation beam were confined within an 18-mm circle. Tightly packed sensor configurations yielded higher output intensity with fewer particles, even after luminophore concentration effects were removed. Most importantly, for the visible wavelengths studied, the ability to measure spectral changes in emission due to glucose changes was not significantly affected by absorption and scattering of tissue, which supports the potential to accurately track changes in luminescence of sensor implants that respond to the biochemistry of the skin.
Long
Ruiqi
R
Texas A&M University, Biomedical Engineering, College Station, Texas 77843-3120, USA.
McShane
Mike
M
D000818:Animals; D015374:Biosensing Techniques; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D009010:Monte Carlo Method; D019736:Prostheses and Implants; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012879:Skin Physiological Phenomena; D014159:Transducers
Phys Med Biol. 1997 Jan;42(1):51-65
9015808
Appl Opt. 1989 Oct 15;28(20):4286-92
20555864
Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:2972-5
18002619
Sens Actuators B Chem. 1995 Oct;29(1-3):16-24
33867678
Anal Chem. 1990 Nov 1;62(21):2377-80
2291483
J Biomed Opt. 2001 Oct;6(4):385-96
11728196
Biosens Bioelectron. 2010 Jan 15;25(5):1075-81
19926464
Med Phys. 1983 Nov-Dec;10(6):824-30
6656695
Biotechnol Bioeng Symp. 1979;(9):65-71
94999
J Biomed Opt. 2003 Apr;8(2):223-36
12683848
IEEE Trans Biomed Eng. 1989 Dec;36(12):1146-54
2606488
J Fluoresc. 2004 Sep;14(5):585-95
15617265
Appl Opt. 1998 Nov 1;37(31):7429-36
18301577
IEEE Trans Biomed Eng. 1996 Feb;43(2):113-22
8682522
Appl Opt. 1998 May 1;37(13):2781-7
18273224
Lasers Surg Med. 1997;21(2):166-78
9261794
Diabetes Technol Ther. 2004 Apr;6(2):191-200
15117585
Anal Chem. 2005 Sep 1;77(17):5501-11
16131059
J Nutr. 2001 May;131(5):1596S-604S
11340124
J Photochem Photobiol B. 1997 Apr;38(2-3):234-40
9203387
Anal Chem. 2000 Sep 1;72(17):4185-92
10994982
IEEE Trans Biomed Eng. 2000 May;47(5):624-32
10851806
Diabetes Technol Ther. 2002;4(4):533-8
12396748
Opt Lett. 2002 Jan 15;27(2):104-6
18007726
Appl Opt. 2000 Jul 1;39(19):3344-56
18349903
Anal Chem. 2007 Feb 15;79(4):1339-48
17297932
Anal Chem. 2008 Mar 1;80(5):1408-17
18237153
Anal Chem. 1999 Aug 1;71(15):3126-32
10450158