Adenoma incidence after resection of sporadic colorectal cancer with microsatellite instability.
OBJECTIVE
Microsatellite instability (MSI) tumors that develop via the mismatch repair (MMR) gene pathway show rapid growth. It is unknown if patients with sporadic colorectal cancer (CRC) with MSI would benefit from a shorter interval between colonoscopies. The purpose of this study is to determine if there is a difference in adenoma incidence based on the presence of MSI in patients with sporadic CRC.


METHODS
We retrospectively reviewed the incidence of a recurring adenoma at the 1- and 3-year surveillance colonoscopies in 426 patients who had sporadic CRC after surgery


RESULTS
The number of high MSI (MSI-H), low MSI (MSI-L), and microsatellite stable (MSS) tumors were 38 (9%), 27 (6%), and 361 (85%), respectively. After 1 year, the incidence of adenoma (13% vs. 16% for MSI-L + MSS vs. MSI-H, P = 0.61) or advanced adenoma (3% vs. 8% for MSI-L + MSS vs. MSI-H, P = 0.14) did not differ based on MSI status. The incidence of adenoma or advanced adenoma also did not differ based on MSI status at the 3-year surveillance colonoscopy.


CONCLUSIONS
Our study does not show recommendations for a shorter interval for subsequent colonoscopies in patients with sporadic CRC with MSI-H. Further studies on a large scale are needed.
Kang
Ki Joo
KJ
Department of Medicine and Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sinn
Dong Hyun
DH
Park
Sung Hyun
SH
Kim
Jin Yong
JY
Chang
Dong Kyung
DK
Son
Hee Jung
HJ
Rhee
Poong-Lyul
PL
Kim
Jae J
JJ
Rhee
Jong Chul
JC
Chun
Ho-Kyung
HK
Kim
Young-Ho
YH
D000236:Adenoma / Q000453:epidemiology* / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery; D003082:Colectomy; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery; D005260:Female; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery; D012189:Retrospective Studies