title: Interpreting NHANES biomonitoring data, cadmium.
abstract: Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet. Chronic Cd exposure is a public health concern because Cd is a known carcinogen; it accumulates in the body and causes kidney damage. The National Health and Nutritional Examination Survey (NHANES) has measured urinary Cd; the 2003-2004 NHANES survey cycle reported estimates for 2257 persons aged 6 years and older in the Fourth National Report on Human Exposure to Environmental Chemicals. As part of translational research to make computerized models accessible to health risk assessors we re-coded a cadmium model in Berkeley Madonna simulation language. This model was used in our computational toxicology laboratory to predict the urinary excretion of cadmium. The model simulated the NHANES-measured data very well from ages 6 to 60+ years. An unusual increase in Cd urinary excretion was observed among 6-11-year-olds, followed by a continuous monotonic rise into the seventh decade of life. This observation was also made in earlier studies that could be life stage-related and a function of anatomical and phsysiological changes occurring during this period of life. Urinary excretion of Cd was approximately twofold higher among females than males in all age groups. The model describes Cd's cumulative nature in humans and accommodates the observed variation in exposure/uptake over the course of a lifetime. Such models may be useful for interpreting biomonitoring data and risk assessment.
authors.affiliation: Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA. pruiz@cdc.gov
authors.forename: Patricia
authors.initials: P
authors.lastname: Ruiz
authors.forename: Moiz
authors.initials: M
authors.lastname: Mumtaz
authors.forename: John
authors.initials: J
authors.lastname: Osterloh
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Fisher
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Fowler
mesh_terms: D000293:Adolescent; D000328:Adult; D002104:Cadmium / Q000032:analysis / Q000652:urine*; D002648:Child; D003627:Data Interpretation, Statistical; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D002104:Cadmium