Polymorphisms in the GNB3 and ADD1 genes and blood pressure in a Chinese population.
A large proportion of the phenotypic variation in blood pressure (BP) appears to be inherited as a polygenic trait. This study examined the association between 12 single nucleotide polymorphisms (SNPs) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) and adducin 1 alpha (ADD1) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP. A total of 3,142 individuals from 636 families were recruited from rural north China, and 2,746 met the eligibility criteria for analysis. BP measurements were obtained using a random-zero sphygmomanometer. Genetic variants were determined using SNPlex assays on an automated DNA Sequencer. A mixed linear model was used to estimate the association between each SNP and BP level. After Bonferroni correction, marker rs4963516 of the GNB3 gene remained significantly associated with DBP (corrected P values = 0.006, 0.007 and 0.002 for co-dominant, additive, and recessive models, respectively) and MAP (corrected P values = 0.02, 0.049, and 0.005, respectively). Compared to carriers of the major A allele, CC homozygotes had higher mean DBP (75.81 +/- 0.62 vs. 73.46 +/- 0.25 mmHg, P = 0.0002) and MAP (91.87 +/- 0.68 vs. 89.42 +/- 0.28 mmHg, P = 0.0004) after adjusting for covariates of age, gender, BMI, study site, and room temperature during BP measurement. In summary, these data support a role for the GNB3 gene in BP regulation in the Chinese population. Future studies aimed at replicating these novel findings are warranted.
Chen
Shufeng
S
Division of Population Genetics, Department of Evidence Based Medicine, Cardiovascular Institute, Fu Wai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing, 100037, China.
Wang
Hongwei
H
Lu
Xiangfeng
X
Liu
De-Pei
DP
Chen
Jing
J
Jaquish
Cashell E
CE
Rao
Dabeeru C
DC
Hixson
James E
JE
Kelly
Tanika N
TN
Hou
Liping
L
Wang
Laiyuan
L
Huang
Jianfeng
J
Chen
Chung-Shiuan
CS
Rice
Treva K
TK
Whelton
Paul K
PK
He
Jiang
J
Gu
Dongfeng
D
D000483:Alleles; D001158:Arteries; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics* / Q000494:pharmacology; D002681:China; D005260:Female; D020962:Heterotrimeric GTP-Binding Proteins; D006801:Humans; D007022:Hypotension / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D020962:Heterotrimeric GTP-Binding Proteins; D000099291:Adducins; C454420:G-protein beta3 subunit
Hypertension. 2002 Feb;39(2 Pt 2):357-62
11882573
Pharmacogenomics. 2007 May;8(5):465-72
17465710
Ann Hum Genet. 2005 Jul;69(Pt 4):468-73
15996174
Hypertension. 1998 Sep;32(3):510-3
9740618
Hypertension. 2000 Jun;35(6):1297-300
10856280
Hypertens Res. 2004 Jan;27(1):31-7
15055253
Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1536-49
16278339
J Hypertens. 2001 Dec;19(12):2149-55
11725157
Nat Genet. 2002 Jan;30(1):97-101
11731797
J Hum Hypertens. 2007 Aug;21(8):639-46
17443206
Hypertension. 2005 Mar;45(3):331-40
15699449
Am J Hum Genet. 2007 Sep;81(3):559-75
17701901
Am J Hypertens. 1998 Apr;11(4 Pt 1):502-6
9607391
Blood Press. 2001;10(5-6):254-70
11822531
J Hypertens. 1993 Mar;11(3):231-6
8387080
Am J Hypertens. 2007 Sep;20(9):981-9
17765140
Lancet. 1997 May 10;349(9062):1353-7
9149697
Hypertension. 1998 Dec;32(6):1094-7
9856980
Clin Exp Pharmacol Physiol. 2006 Mar;33(3):248-52
16487269
J Mol Med (Berl). 2003 Nov;81(11):729-35
13679998
Hypertension. 1995 Oct;26(4):649-55
7558226
Hypertension. 2002 Feb;39(2):191-6
11847182
N Engl J Med. 1999 Apr 1;340(13):1012-20
10099144
Bioinformatics. 2001 Aug;17(8):742-3
11524377
Hypertension. 2000 Oct;36(4):477-83
11040222
Circulation. 1993 Nov;88(5 Pt 1):2460-70
8222141
Nat Genet. 1998 Jan;18(1):45-8
9425898
Am J Hum Genet. 1998 Jul;63(1):259-66
9634505