title: [Tuberous sclerosis: evaluation of myofibroblasts in cutaneous angiofibromas - case report].
abstract: Tuberous sclerosis is a rare autosomal dominant disorder. Myofibroblasts are cells with a hybrid phenotype between fibroblasts and smooth muscle cells. The objective of this study is to describe clinical and histopathological characteristics of tuberous sclerosis and to conduct an immunohistochemical evaluation of myofibroblasts in cutaneous angiofibromas present in this condition. Lesion sections removed were stained with hematoxylin-eosin and Masson's trichrome. Immunohistochemistry against alpha-SMA was done to determine the presence of myofibroblasts, and the reaction was negative. Since alpha-SMA is a specific marker for myofibroblasts, this result suggests that myofibroblasts are not involved in cutaneous angiofibromas present in the tuberous sclerosis case reported.
authors.affiliation: Universidade de Alfenas, Brasil.
authors.forename: Erick Gomes
authors.initials: EG
authors.lastname: Perez
authors.forename: Lívia Ribeiro
authors.initials: LR
authors.lastname: Paranaíba
authors.forename: Paulo Rogério
authors.initials: PR
authors.lastname: Bonan
authors.forename: Julian Miranda
authors.initials: JM
authors.lastname: Orsi Júnior
authors.forename: Adriano Macedo de
authors.initials: AM
authors.lastname: Oliveira
authors.forename: Hercílio
authors.initials: H
authors.lastname: Martelli Júnior
mesh_terms: D000293:Adolescent; D018322:Angiofibroma / Q000150:complications* / Q000473:pathology*; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology*; D014402:Tuberous Sclerosis / Q000150:complications*