Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions.
Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This review will provide a general outline of the replicative cycle of non-LTR retrotransposons. Recent findings regarding the host regulation of non-LTR retrotransposons will be summarized. Finally, future directions of interest will be discussed.
Han
Jeffrey S
JS
Department of Embryology, Carnegie Institution of Washington, Baltimore, MD, USA. han@ciwemb.edu.
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