title: Disruption of brain white matter microstructure in primary Sjögren's syndrome: evidence from diffusion tensor imaging.
abstract: OBJECTIVE
  The relationship between cognitive symptoms and underlying neuropathology in primary SS (PSS) is poorly understood. We used high-resolution quantitative brain MRI to identify potential structural correlates of cognitive symptoms.
  
  
  METHODS
  Subjects completed a comprehensive neuropsychometric evaluation. Imaging was performed on a 3 T MRI scanner with T(1) and proton density-weighted, fluid-attenuated inversion recovery (FLAIR) and diffusion tensor imaging (DTI) sequences. We compared MRI group metrics (impaired PSS, not-impaired PSS and controls) and tested for correlations between DTI results and neuropsychological measurements (significance threshold P = 0.05).
  
  
  RESULTS
  Nineteen PSS patients (who met American-European Consensus Group 2002 criteria) and 17 healthy controls completed the cognitive evaluation. MRI scans were performed in six impaired PSS, seven not-impaired PSS and seven controls. No differences were found in regional volumetrics, nor was there a difference in T(2) lesion load between groups. Fractional anisotropy (FA) in the inferior frontal white matter (WM) was lower (P = 0.021) and mean diffusivity higher (P = 0.003) in the impaired PSS relative to the control group. Inferior frontal FA was correlated with cognitive symptoms (P = 0.0064) and with verbal memory (P = 0.0125).
  
  
  CONCLUSIONS
  In this exploratory study, frontal region WM microstructure alterations accompanied cognitive symptoms and were associated with mild cognitive impairment in PSS. While additional study is warranted to assess the specificity and stability of these results, DTI could provide novel insight into the pathological processes accompanying the subtle cognitive dysfunction commonly experienced by PSS patients.
authors.affiliation: Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. segal017@umn.edu
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Segal
authors.forename: Bryon A
authors.initials: BA
authors.lastname: Mueller
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Zhu
authors.forename: Rachel
authors.initials: R
authors.lastname: Prosser
authors.forename: Brian
authors.initials: B
authors.lastname: Pogatchnik
authors.forename: Erin
authors.initials: E
authors.lastname: Holker
authors.forename: Adam F
authors.initials: AF
authors.lastname: Carpenter
authors.forename: Kelvin O
authors.initials: KO
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000648:ultrastructure*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*; D055815:Young Adult