Animal models of neurological disease.
The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology. These models have been the source of a plethora of information, such as the importance of certain molecular mechanisms and genetic contributions in neurological disease. Additionally, animal models have been utilized in the discovery and testing of possible therapeutic treatments. Although most neurological diseases are still not yet completely understood and reliable treatment is lacking, animal models provide a major step in the right direction.
Shah
Amol
A
UCSD School of Medicine, San Diego, California, USA.
Garzon-Muvdi
Tomas
T
Mahajan
Rohit
R
Duenas
Vincent J
VJ
Quiñones-Hinojosa
Alfredo
A
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D018663:Adrenergic Agents / Q000494:pharmacology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology; D002490:Central Nervous System / Q000187:drug effects / Q000473:pathology / Q000502:physiology / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D008694:Methamphetamine / Q000494:pharmacology; D009422:Nervous System Diseases / Q000473:pathology / Q000503:physiopathology; D009498:Neurotoxins / Q000494:pharmacology; D016627:Oxidopamine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012402:Rotenone / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology
D018663:Adrenergic Agents; D016564:Amyloid beta-Protein Precursor; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D009498:Neurotoxins; D014475:Uncoupling Agents; D012402:Rotenone; D008694:Methamphetamine; D012110:Reserpine; D016627:Oxidopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine