Sickle cell disease and the eye: old and new concepts.
The pathophysiology of sickle cell disease is not limited to abnormal red blood cells. The clinical manifestations of sickle cell disease include complex pathways and processes such as endothelial activation, inflammation, bioavailability of nitric oxide, oxidative stress, and the adhesiveness of a variety of blood cells. Increasingly, distinct subphenotypes and genetic modifiers of sickle cell disease are being recognized. We apply recent advances in sickle cell disease to ocular biology to highlight translational research in this field and encourage additional studies on the ocular manifestations of sickle cell disease.
Elagouz
Mohammed
M
Laser and Retinal Research Unit, Department of Ophthalmology, King's College Hospital, Denmark Hill, London, United Kingdom.
Jyothi
Sreedhar
S
Gupta
Bhaskar
B
Sivaprasad
Sobha
S
D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000503:physiopathology*; D006801:Humans