title: Treatment of hypertension in the elderly in 2010 - a brief review.
abstract: BACKGROUND
  Populations, the world over, age. Prevalence of hypertension increases with advancing age. Despite the advances over the past 30 years, there are still unresolved issues regarding antihypertensive therapy in the elderly.
  
  
  METHODS
  The present review discusses the available evidence supporting treatment of hypertension in the elderly.
  
  
  RESULTS
  In the 1980s and 1990s, a number of trials were performed and proved that active treatment of hypertension in individuals above the age of 60 - 65 years, compared with placebo or no treatment, reduces the risk of complications. In the 1990s, the same was proven in patients specifically affected with isolated systolic hypertension, the predominant form of hypertension in the elderly. The subsequent years witnessed the publication of trials that showed that most antihypertensive drugs are capable of substantially reducing risk. Finally, treatment of hypertension in the very elderly was proven to be beneficial.
  
  
  CONCLUSIONS
  In spite of these advances, we still lack evidence in elderly patients with mild isolated systolic hypertension and are therefore in need of a properly designed, randomized, placebo-controlled trial.
authors.affiliation: Jagiellonian University, Department of Internal Medicine and Gerontology, 10 Śniadeckich St, 31-537 Kraków, Poland. jerzy.gasowski@wp.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gąsowski
authors.forename: Valérie
authors.initials: V
authors.lastname: Tikhonoff
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Stolarz-Skrzypek
authors.forename: Lutgarde
authors.initials: L
authors.lastname: Thijs
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzicki
authors.forename: Kalina
authors.initials: K
authors.lastname: Kawecka-Jaszcz
authors.forename: Jan A
authors.initials: JA
authors.lastname: Staessen
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence
chemical_list: D000959:Antihypertensive Agents