title: Long survival and clinical stability in Marburg's variant multiple sclerosis.
abstract: Marburg's variant multiple sclerosis (MS) is an acute and aggressive atypical form of MS, leading frequently to death in few months. A 32-year-old man with motor and sensory symptoms suggestive of acute myelopathy, rapidly followed by cerebellar dysfunction and consciousness impairment. Clinical, laboratory and radiological evaluations suggested a central nervous system demyelinating disease. The diagnosis was Marburg's variant MS, usually leading to death in short time. He underwent different treatments, including steroids, cyclophosphamide, plasma exchange and lastly interferon-beta. The patient reached clinical stability with severe residual disability, persistent after 3 years from onset. This observation suggests that subjects with Marburg's MS might reach long clinical stability.
authors.affiliation: Section of Neurology, Department of Neurological and Vision Sciences, University of Verona, Policlinico G. Rossi, Piazzale L.A. Scuro, 10, Verona, Italy. marco.turatti@univr.it
authors.forename: Marco
authors.initials: M
authors.lastname: Turatti
authors.forename: Alberto
authors.initials: A
authors.lastname: Gajofatto
authors.forename: Francesca
authors.initials: F
authors.lastname: Rossi
authors.forename: Marcella
authors.initials: M
authors.lastname: Vedovello
authors.forename: Maria Donata
authors.initials: MD
authors.lastname: Benedetti
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D009103:Multiple Sclerosis / Q000145:classification / Q000188:drug therapy / Q000628:therapy*; D010951:Plasma Exchange; D011379:Prognosis; D017741:Survivors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016899:Interferon-beta; D003520:Cyclophosphamide
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