Differing obstetric outcomes of rosacea fulminans in pregnancy: report of three cases with review of pathogenesis and management.
Rosacea fulminans (RF) is a rare facial dermatosis characterized by the sudden onset of severe facial inflammation consisting of numerous pustules, cystic swellings and coalescing sinuses. The standard treatment is the retinoid drug isotretinoin in combination with systemic corticosteroids or with high-dose oral tetracycline antibiotics. We report three recent cases of RF in pregnancy with differing obstetric outcomes: an intrauterine death, a termination of pregnancy, and a normal vaginal delivery. The pathogenesis of RF is considered and therapeutic options in pregnancy are reviewed.
Jarrett
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R
Department of Core Medicine, Bristol Royal Infirmary, United Bristol Healthcare Trust, Bristol, UK. rachaeljarrett@doctors.org.uk
Gonsalves
R
R
Anstey
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AV
D000028:Abortion, Induced; D000152:Acne Vulgaris / Q000150:complications; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D016640:Diabetes, Gestational; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005313:Fetal Death; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use; D016104:Oligohydramnios / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012393:Rosacea / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D005938:Glucocorticoids; D004917:Erythromycin; D011239:Prednisolone; D015474:Isotretinoin