Dysfunctional niches as a root of hematopoietic malignancy.
Whether the bone marrow microenvironment can contribute to development of blood borne cancers is controversial. In a recent issue of Nature, Raaijmakers et al. (2010) show that deletion of Dicer1 specifically in osteoprogenitors not only impaired their differentiation but also resulted in disrupted blood formation and secondary leukemia.
Shiozawa
Yusuke
Y
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
Taichman
Russell S
RS