A General Strategy to Prepare TiO(2)-core Gold-shell Nanoparticles as SERS-tags.
The synthesis and characterization of TiO(2)-based core-shell nanoparticles as surface-enhanced Raman Scattering (SERS) tags are reported. A hydrolysis approach is first used to generate colloidal TiO(2) nanoparticles, which are subsequently tagged with Raman probe molecules and encapsulated within a gold nanoshell. The resulting core-shell nanoparticles are characterized by using a number of techniques including UV-visible spectroscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy (EDX) to confirm the successful coating of the Au shells. These core-shell nanoparticles exhibit very strong and reproducible SERS signals of the Raman probe molecules. Three different types of Raman probe molecules are used to prepare different SERS-active nanoparticles (SERS-tags), which demonstrates the versatility of the design. Such TiO(2)-based metal-coated core-shell nanoparticles will be useful as SERS-tags in biological assay and imaging applications. They may also provide a platform for fundamental studies in the ongoing investigations on the mechanisms of SERS.
Li
Wenbing
W
Department of Chemistry, New Mexico Tech, Socorro, New Mexico 87801.
Guo
Yanyan
Y
Zhang
Peng
P
Nat Nanotechnol. 2009 Sep;4(9):571-6
19734929
J Am Chem Soc. 2005 Mar 30;127(12):4484-9
15783231
Phys Rev Lett. 1996 Apr 1;76(14):2444-2447
10060701
Anal Chem. 2004 Jan 1;76(1):78-85
14697035
Anal Bioanal Chem. 2006 Nov;386(5):1379-86
16933128
Analyst. 2007 Dec;132(12):1210-4
18318281
Science. 2003 Oct 17;302(5644):419-22
14564001
J Am Chem Soc. 2003 Aug 13;125(32):9598-9
12904020
J Phys Chem C Nanomater Interfaces. 2008 Mar 11;112(13):4880-4883
19424458
J Am Chem Soc. 2009 Mar 25;131(11):3808-9
19243178
Science. 1997 Feb 21;275(5303):1102-6
9027306
J Phys Chem B. 2005 Jan 13;109(1):312-20
16851017
Acc Chem Res. 2008 Dec;41(12):1742-9
18783255
J Am Chem Soc. 2007 Dec 26;129(51):16249-56
18052068
Nat Mater. 2008 Jun;7(6):442-53
18497851
Anal Chem. 2001 Aug 1;73(15):3674-8
11510833
Science. 2007 Oct 19;318(5849):430-3
17947577
Langmuir. 2005 Jan 18;21(2):520-3
15641817
J Phys Chem B. 2005 Jul 28;109(29):13857-70
16852739
Science. 2002 Aug 30;297(5586):1536-40
12202825
J Am Chem Soc. 2004 Apr 28;126(16):5225-33
15099107
Curr Opin Chem Biol. 2003 Oct;7(5):609-15
14580566
Acc Chem Res. 2006 Apr;39(4):249-57
16618092
Nat Biotechnol. 2008 Jan;26(1):83-90
18157119
J Am Chem Soc. 2004 Jun 23;126(24):7608-18
15198609
Chem Rev. 1999 Oct 13;99(10):2957-76
11749507
Acc Chem Res. 2007 Jan;40(1):53-62
17226945
Curr Opin Biotechnol. 2003 Feb;14(1):13-22
12565997
Chem Rev. 2005 Apr;105(4):1171-96
15826012