Murine spleen lymphocytes apoptosis in the experimental model of staphylococcal intravaginal infection.
The results of research on changes in the level of apoptosis among the spleen cells during the development of intravaginal staphylococcal infection in experimental models of different genetic mice lines are given in the paper. Intravaginal injection of Staphylococcus aureus resulted in an increased number of cells with morphological characteristics of apoptosis in underbred and line BALB/c mice, while it decreased in the ICR line mice. The level of the apoptotic cells in the underbred and line BALB/c mice was accompanied by some level of microorganisms that were seeded out of kidneys--the higher was the number of microorganisms, the more apoptotic cells were indicated.
Spivak
N Ja
NJ
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Acad Zabolotny St., Kyiv, MCP, D03680, Ukraine. Spivak@serv.imv.kiev.ua
Babenko
L R
LR
Mokrozub
V V
VV
Kishko
K M
KM
Lazarenko
L N
LN
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D005260:Female; D007668:Kidney / Q000382:microbiology; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D013045:Species Specificity; D013154:Spleen / Q000276:immunology / Q000473:pathology*; D013203:Staphylococcal Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000254:growth & development; D016585:Vaginosis, Bacterial / Q000276:immunology / Q000382:microbiology / Q000473:pathology*