Research on Blastocyst Implantation Essential Factors (BIEFs).
Blastocyst implantation is a process of interaction between embryo and the uterus. To understand this process, this review tries to summarize what blastocyst implantation essential factors (BIEFs) play what roles, as well as where in the uterus and at what stage of implantation process. Addition of more new data to this kind of compilation of information will help the development of diagnosis and treatment of infertility caused by implantation failure. The major, important cells of the endometrial cells that interact with invading blastocyst (trophoblast) are luminal epithelial cells, stromal cells (decidual cells) and resident immune cells. BIEFs regulate these cells to successfully maintain pregnancy.
Yoshinaga
Koji
K
Reproductive Sciences Branch, Center for Population Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, MD 20892-7510, USA. ky6a@nih.gov
D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000166:cytology* / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D007107:Immune System / Q000166:cytology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000166:cytology / Q000378:metabolism
C587883:HBEGF protein, human; C587884:Hbegf protein, mouse; C587885:Hbegf protein, rat; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins