[Influence of obstructive sleep apnea hypopnea syndrome on endothelial function and autonomic modulation].
OBJECTIVE
To explore the influence of obstructive sleep apnea hypopnea syndrome (OSAHS) on endothelial function and autonomic modulation.


METHODS
Electrocardiogram and beat-to-beat blood pressure from the radial artery were continuously recorded by polysomnography and applanation tonometry, respectively in OSAHS patients (OSAHS group, n=20) and obese controls (control group, n=20). Vascular endothelial function was evaluated by arterial augmentation index (AAI), and autonomic modulation was evaluated by heart rate variability (HRV) and blood pressure variability (BPV).


RESULTS
The baseline AAI and BPV low frequency (LF) were significantly higher in OSAHS group than in control group (P<0.05). Compared with the pre-sleep levels, systolic blood pressure, diastolic blood pressure, HRV LF, HRV LF/high frequency and BPV LF significantly increased after over-night sleeps in OSAHS group (P<0.001), while HRV high frequency significantly decreased (P<0.05).


CONCLUSIONS
OSAHS patients usually have endothelial dysfunction and autonomic modulation disorder, which are independently related with OSAHS.
Zhong
Xu
X
Department of Respiratory Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xiao
Yi
Y
Huang
Rong
R
D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*