title: Effect of bio-oss collagen and collagen matrix on bone formation.
abstract: OBJECTIVE
  to compare the amount of new bone produced by Bio-Oss((R)) Collagen to that produced by collagen matrix in vivo.
  
  
  METHODS
  eighteen bone defects, 5mm by 10mm were created in the parietal bone of 9 New Zealand White rabbits. 6 defects were grafted with Bio-Oss((R)) Collagen. 6 defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis.
  
  
  RESULTS
  A total of 339% more new bone was present in defects grafted with Bio-Oss((R)) Collagen than those grafted with collagen matrix (positive control). No bone was formed in the negative control group.
  
  
  CONCLUSIONS
  Bio-Oss((R)) Collagen has the effect of stimulating new bone formation locally compared with collagen matrix in vivo. Bio-Oss((R) )Collagen may be utilized as a bone graft material.
authors.affiliation: Biomedical and Tissue Engineering, University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong.
authors.forename: R W K
authors.initials: RW
authors.lastname: Wong
authors.forename: A B M
authors.initials: AB
authors.lastname: Rabie
references.citation: J Craniofac Surg. 2005 Sep;16(5):778-89
references.pmid: 16192856
references.citation: J Oral Maxillofac Surg. 2006 May;64(5):770-7
references.pmid: 16631483
references.citation: Int J Oral Maxillofac Surg. 1986 Jun;15(3):269-72
references.pmid: 3088154
references.citation: J Bone Joint Surg Br. 1973 May;55(2):402-17
references.pmid: 4574991
references.citation: Int J Oral Maxillofac Implants. 1993;8(1):45-53
references.pmid: 8468086
references.citation: Br J Oral Maxillofac Surg. 2003 Aug;41(4):244-8
references.pmid: 12946667
references.citation: Osteoarthritis Cartilage. 2007 Aug;15(8):894-9
references.pmid: 17379543
references.citation: J Biomed Mater Res A. 2008 May;85(2):506-12
references.pmid: 17729265
references.citation: Eur J Orthod. 1999 Apr;21(2):119-26
references.pmid: 10327735
references.citation: Clin Orthop Relat Res. 1983 Apr;(174):28-42
references.pmid: 6339139
references.citation: Clin Oral Implants Res. 1998 Apr;9(2):107-16
references.pmid: 9663038
references.citation: Front Biosci (Landmark Ed). 2009 Jan 01;14:3673-9
references.pmid: 19273301
references.citation: Clin Oral Implants Res. 1997 Apr;8(2):117-24
references.pmid: 9758962
references.citation: Clin Oral Implants Res. 2008 Dec;19(12):1219-25
references.pmid: 19040436
references.citation: Clin Oral Implants Res. 2008 Aug;19(8):796-803
references.pmid: 18705811
references.citation: J Orthop Res. 2008 Aug;26(8):1061-6
references.pmid: 18383168
references.citation: Plast Reconstr Surg. 1983 Dec;72(6):778-85
references.pmid: 6196801
references.citation: Biomaterials. 2006 Mar;27(9):1824-31
references.pmid: 16310246
references.citation: Int J Oral Maxillofac Surg. 1992 Aug;21(4):204-9
references.pmid: 1328414