Comparison of endoscopy, histology, and cytokine mRNA of the equine gastric mucosa.
In recent years, gastric ulceration has been recognized as a common, possibly performance-limiting disease, of adult horses. The aim of this study was to compare endoscopic features, histological diagnosis, and mRNA levels of various cytokines (TNF-alpha, IL-1beta, and IL-13) from horse gastric biopsies. Eleven horses suffering from equine gastric ulcer syndrome and seven horses with normal histological gastric features were assessed. No correlation between endoscopic features and histology (i.e., the gold standard) was observed. Based on histological diagnosis, a significant (p < 0.05) increase in cytokine mRNA levels (specifically, TNF-alpha and IL-13) was observed in horses affected by equine ulcerative gastric syndrome.
Pietra
M
M
Department of Veterinary Clinical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy. marco.pietra@unibo.it
Morini
M
M
Perfetti
G
G
Spadari
A
A
Vigo
P
P
Peli
A
A
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D016099:Endoscopy, Gastrointestinal / Q000662:veterinary*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation / Q000502:physiology; D006734:Horse Diseases / Q000378:metabolism / Q000473:pathology*; D006736:Horses; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
D016207:Cytokines; D012333:RNA, Messenger
Aust Vet J. 2003 Apr;81(4):199-201
15080440
J Vet Med A Physiol Pathol Clin Med. 2007 Apr;54(3):161-8
17381682
BMC Vet Res. 2008 Feb 23;4:8
18294392
Vet Res Commun. 2008 Sep;32 Suppl 1:S275-7
18683069
Vet Microbiol. 2008 Apr 1;128(1-2):178-93
18054447
N Z Vet J. 2007 Feb;55(1):1-12
17339910
Am J Vet Res. 2006 Apr;67(4):669-77
16579761