title: Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review.
abstract: Temozolomide chemotherapy has become part of the therapy used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Temozolomide frequently produces profound lymphopenia. We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the literature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation.
authors.affiliation: Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Madrid, Spain. yolandameije@gmail.com
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Meije
authors.forename: Manuel
authors.initials: M
authors.lastname: Lizasoain
authors.forename: Ana
authors.initials: A
authors.lastname: García-Reyne
authors.forename: Pilar
authors.initials: P
authors.lastname: Martínez
authors.forename: Virginia
authors.initials: V
authors.lastname: Rodríguez
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Medrano
authors.forename: Rafael San
authors.initials: RS
authors.lastname: Juan
authors.forename: Antonio
authors.initials: A
authors.lastname: Lalueza
authors.forename: José María
authors.initials: JM
authors.lastname: Aguado
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000188:drug therapy; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide