title: Neural mechanisms of repetition priming of familiar and globally unfamiliar visual objects.
abstract: Functional magnetic resonance imaging (fMRI) studies have shown that repetition priming of visual objects is typically accompanied by a reduction in activity for repeated compared to new stimuli (repetition suppression). However, the spatial distribution and direction (suppression vs. enhancement) of neural repetition effects can depend on the pre-experimental familiarity of stimuli. The first goal of this study was to further probe the link between repetition priming and repetition suppression/enhancement for visual objects and how this link is affected by stimulus familiarity. A second goal was to examine whether priming of familiar and unfamiliar objects following a single stimulus repetition is supported by the same processes as priming following multiple repetitions within the same task. In this endeavor, we examined both between and within-subject correlations between priming and fMRI repetition effects for familiar and globally unfamiliar visual objects during the first and third repetitions of the stimuli. We included reaction time of individual trials as a linear regressor to identify brain regions whose repetition effects varied with response facilitation on a trial-by-trial basis. The results showed that repetition suppression in bilateral fusiform gyrus, was selectively correlated with priming of familiar objects that had been repeated once, likely reflecting facilitated perceptual processing or the sharpening of perceptual representations. Priming during the third repetition was correlated with repetition suppression in prefrontal and parietal areas for both familiar and unfamiliar stimuli, possibly reflecting a shift from top-down controlled to more automatic processing that occurs for both item types.
authors.affiliation: Department of Psychology, University of Massachusetts - Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02747, USA.
authors.forename: Anja
authors.initials: A
authors.lastname: Soldan
authors.forename: Christian
authors.initials: C
authors.lastname: Habeck
authors.forename: Yunglin
authors.initials: Y
authors.lastname: Gazes
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern
mesh_terms: D000328:Adult; D001931:Brain Mapping; D006801:Humans; D007858:Learning / Q000502:physiology*; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology*; D013663:Teaching; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*; D055815:Young Adult
references.citation: J Neurophysiol. 2007 May;97(5):3532-43
references.pmid: 17344370
references.citation: J Neurosci. 2007 May 30;27(22):5981-5
references.pmid: 17537969
references.citation: Curr Opin Neurobiol. 2007 Apr;17(2):171-6
references.pmid: 17303410
references.citation: Nat Neurosci. 2002 May;5(5):491-9
references.pmid: 11967545
references.citation: Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13494-9
references.pmid: 8942962
references.citation: Neuropsychologia. 2001;39(2):184-99
references.pmid: 11163375
references.citation: J Neurosci. 2008 Sep 24;28(39):9790-6
references.pmid: 18815263
references.citation: Curr Opin Neurobiol. 1998 Apr;8(2):227-33
references.pmid: 9635206
references.citation: Nature. 1995 Aug 17;376(6541):587-90
references.pmid: 7637806
references.citation: Neuropsychopharmacology. 2002 Aug;27(2):282-92
references.pmid: 12093602
references.citation: Neuroscience. 2006 Apr 28;139(1):209-21
references.pmid: 16324796
references.citation: Neuron. 1999 Sep;24(1):187-203
references.pmid: 10677037
references.citation: Neuroimage. 2005 Apr 15;25(3):815-23
references.pmid: 15808982
references.citation: J Cogn Neurosci. 2004 Jul-Aug;16(6):966-77
references.pmid: 15298784
references.citation: Nature. 2004 Mar 18;428(6980):316-9
references.pmid: 14990968
references.citation: Neuropsychologia. 2003;41(3):263-70
references.pmid: 12457752
references.citation: Cereb Cortex. 2007 Feb;17(2):425-33
references.pmid: 16565294
references.citation: Science. 2000 Feb 18;287(5456):1269-72
references.pmid: 10678834
references.citation: Neuroimage. 2007 Oct 1;37(4):1083-90; discussion 1097-9
references.pmid: 17719799
references.citation: J Neurosci. 2005 Mar 30;25(13):3414-22
references.pmid: 15800196
references.citation: Brain. 2005 Apr;128(Pt 4):773-87
references.pmid: 15705615
references.citation: Neurobiol Learn Mem. 2005 May;83(3):251-62
references.pmid: 15820861
references.citation: J Neurosci. 2001 Sep 1;21(17):6846-52
references.pmid: 11517272
references.citation: Nat Neurosci. 2005 Sep;8(9):1228-33
references.pmid: 16056222
references.citation: Neuron. 2006 Jan 19;49(2):307-18
references.pmid: 16423703
references.citation: Prog Neurobiol. 2003 May;70(1):53-81
references.pmid: 12927334
references.citation: J Exp Psychol Hum Learn. 1980 Mar;6(2):174-215
references.pmid: 7373248
references.citation: Neuroimage. 2008 Jan 1;39(1):515-26
references.pmid: 17913513
references.citation: Cereb Cortex. 2005 Jun;15(6):787-95
references.pmid: 15371295
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references.pmid: 11209064
references.citation: J Cogn Neurosci. 2006 Aug;18(8):1237-52
references.pmid: 16859411
references.citation: J Cogn Neurosci. 2004 Nov;16(9):1625-32
references.pmid: 15601524
references.citation: Brain Res. 2006 Feb 23;1075(1):133-41
references.pmid: 16476414
references.citation: Neuron. 2004 Jun 10;42(5):865-75
references.pmid: 15182724
references.citation: J Neurophysiol. 2006 Feb;95(2):995-1007
references.pmid: 16236787
references.citation: J Cogn Neurosci. 2009 Sep;21(9):1766-81
references.pmid: 18823245
references.citation: Neuropsychologia. 2006;44(10):1765-76
references.pmid: 16701731
references.citation: Neuroimage. 2004 Apr;21(4):1674-89
references.pmid: 15050590
references.citation: Neuropsychologia. 2008;46(7):1979-91
references.pmid: 18328508
references.citation: Behav Brain Res. 1996 Apr;76(1-2):191-7
references.pmid: 8734053
references.citation: Trends Cogn Sci. 2006 Jan;10(1):14-23
references.pmid: 16321563
references.citation: Neuron. 2006 Mar 16;49(6):917-27
references.pmid: 16543138
references.citation: Hum Brain Mapp. 2009 Aug;30(8):2530-41
references.pmid: 19072895