Yeast as a model to study mitochondrial mechanisms in ageing.
Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria-nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms.
Barros
Mario H
MH
Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
da Cunha
Fernanda M
FM
Oliveira
Graciele A
GA
Tahara
Erich B
EB
Kowaltowski
Alicia J
AJ
D000367:Age Factors; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D001343:Autophagy; D031204:Caloric Restriction; D002467:Cell Nucleus / Q000378:metabolism; D019069:Cell Respiration; D004271:DNA, Fungal / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D015398:Signal Transduction
D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species