title: Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics.
abstract: Toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine are diaminotoluenes used as colorants in permanent hair dyes and tints. Toluene-2,5-diamine is used in 79 products at concentrations up to 3%; toluene-2,5-diamine sulfate is used in 168 products at concentrations up to 4%. Toluene-3,4-diamine does not appear to be in current use. Previously, the Cosmetic Ingredient Review Expert Panel determined that all 3 ingredients were safe for use as hair dyes. New data suggest that differences in toxicity, especially with respect to carcinogenicity, may exist as a function of placement of amine groups around the benzene ring. The Expert Panel concluded that toluene-2,5-diamine and toluene-2,5-diamine sulfate and are safe as hair dye ingredients in the present practices of use and concentrations but that there are insufficient data supporting the safety of toluene-3,4-diamine.
authors.affiliation: Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. cirinfo@cir-safety.org
authors.forename: Christina L
authors.initials: CL
authors.lastname: Burnett
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F
authors.initials: F
authors.lastname: Alan Andersen
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D003257:Consumer Product Safety; D005260:Female; D006202:Hair Dyes / Q000633:toxicity*; D006801:Humans; D008297:Male; D010655:Phenylenediamines / Q000737:chemistry / Q000633:toxicity*; D018570:Risk Assessment
chemical_list: D006202:Hair Dyes; D010655:Phenylenediamines; C007303:2,5-diaminotoluene; C011131:3,4-toluenediamine