title: Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis.
abstract: A pair of new isomeric indole alkaloids, naucleaorals A (1) and B (2) were isolated from the roots of Nauclea orientalis. The structures of compounds 1 and 2 were fully characterized using spectroscopic data, and were tested for their cytotoxicity (HeLa and KB cells) and antimalarial activity. Compound 1 showed significant cytotoxicity to HeLa cells with an IC(50) value of 4.0 µg/mL, while compound 2 exhibited very modest cytotoxicity to both cell lines with IC(50) values of 7.8 and 9.5 µg/mL, respectively. Both compounds proved to be inactive in antimalarial assays (IC(50)>10.00 µg/mL).
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Jirapast
authors.initials: J
authors.lastname: Sichaem
authors.forename: Serm
authors.initials: S
authors.lastname: Surapinit
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.forename: Suttira
authors.initials: S
authors.lastname: Khumkratok
authors.forename: Jonkolnee
authors.initials: J
authors.lastname: Jong-aramruang
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007624:KB Cells; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D019666:Rubiaceae / Q000737:chemistry*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D010936:Plant Extracts; C557324:naucleaoral A; C557325:naucleaoral B