title: [Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model].
abstract: OBJECTIVE
  To evaluate the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis of rat.
  
  
  METHODS
  Thirty SD rats free of disease were randomly divided into two groups. A model of allergic rhinitis rat was established by using ovalbumin intraperitoneal immunization and intranasal antigen challenge. The nasal mucosa from 18 out of 20 AR models as well as 10 normal controls were studied for expression of BDNF mRNA by reverse transcription-polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  BDNF/beta-actin ratio in AR models was significantly higher than control (0.49+/-0.07 vs 0.28+/-0.01, P<0.05).
  
  
  CONCLUSIONS
  BDNF played an important role in the development of allergic rhinitis of rat.
authors.affiliation: Department of Otorhinolaryngology, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tao
authors.forename: Fengbing
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Huang
authors.forename: Baobin
authors.initials: B
authors.lastname: Sun
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D009297:Nasal Mucosa / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012333:RNA, Messenger