Integrin alpha 6: anchors away for glioma stem cells.
The laminin receptor Integrin alpha6beta1 anchors adult neural stem cells to the niche vasculature. In this issue of Cell Stem Cell, Lathia et al. (2010) show that glioblastoma stem cells highly express integrin alpha6 and that their interaction with laminin on endothelial cells directly regulates their tumorigenic capacity.
Corsini
Nina S
NS
Department of Molecular Neurobiology, German Cancer Research Center, 69120 Heidelberg, Germany.
Martin-Villalba
Ana
A