Photodynamic therapy for focal ablation of the prostate.
Although in early stages of clinical development, photodynamic therapy (PDT) shows promise in delivering focal treatment of both primary and post-radiotherapy prostate cancer. This article will review the mechanism of action of PDT, previous research using PDT for treating prostate cancer including the development of newer vascular-acting photosensitizers, and the potential advantages and disadvantages of PDT in delivering focal therapy.
Arumainayagam
Nimalan
N
Division of Surgery and Interventional Sciences, National Medical Laser Centre, University College London, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, UK. nim.arum@ucl.ac.uk
Moore
C M
CM
Ahmed
Hashim U
HU
Emberton
M
M
D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use; D008665:Metalloporphyrins / Q000627:therapeutic use; D010778:Photochemotherapy / Q000009:adverse effects; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
D008652:Mesoporphyrins; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; C102825:motexafin lutetium; D017323:Dihematoporphyrin Ether; C072269:temoporfin
Prostate. 1997 Jul 1;32(2):89-98
9215396
Lancet. 1990 Nov 3;336(8723):1139
1978022
J Environ Pathol Toxicol Oncol. 2006;25(1-2):373-87
16566729
Clin Cancer Res. 2001 Mar;7(3):651-60
11297261
J Urol. 2001 May;165(5):1795-801
11342978
Arch Ophthalmol. 2004 Jul;122(7):1002-11
15249365
Clin Cancer Res. 2008 Aug 1;14(15):4869-76
18676760
Radiology. 2007 Jul;244(1):196-204
17507719
Cochrane Database Syst Rev. 2007 Jul 18;(3):CD002030
17636693
J Urol. 2002 Oct;168(4 Pt 1):1427-32
12352410
Gut. 2002 Apr;50(4):549-57
11889078
Lasers Surg Med. 2006 Apr;38(4):325-31
16596660
J Biophotonics. 2008 Aug;1(3):200-3
19412969
Can Urol Assoc J. 2009 Apr;3(2):125-30
19424466
Med Phys. 2007 Nov;34(11):4309-21
18072496
Int J Cancer. 1996 Aug 7;67(4):555-62
8759616
BJU Int. 2008 Aug 5;102(5):556-62
18494829
Adv Drug Deliv Rev. 2004 Jan 13;56(1):53-76
14706445
Int J Cancer. 2002 Apr 10;98(5):793-8
11920653
J Urol. 2007 Nov;178(5):1974-9; discussion 1979
17869307
Br J Cancer. 2004 Aug 2;91(3):441-6
15238981
J Urol. 1996 Jul;156(1):258-60
8648818
Br J Urol. 1997 Dec;80(6):898-902
9439405
Lasers Surg Med. 2006 Jun;38(5):356-63
16392142