Age-related hearing loss or presbycusis.
Aging is a natural consequence of a society developing process. Although many adults retain good hearing as they aging, hearing loss related with age-presbycusis which can vary in severity from mild to substantial is common among elderly persons. There are a number of pathophysiological processes underlying age-related changes in the auditory system as well as in the central nervous systems. Many studies have been dedicated to the illustration of risk factors accumulating presbycusis such as heritability, environment factors, medical conditions, free radical (reactive oxygen species, ROS) and damage of mitochondrial DNA. Left untreated, presbycusis can not only lead sufferers to reduced quality of life, isolation, dependence and frustration, but also affect the healthy people around. These can be partly corrected using hearing aids, but it is not enough, more and more strategies of treatment based on the findings associating with presbycusis should be added rather than using single hearing aids. We review here the pathophysiology; heritability, susceptibility genes and other risk factors including environmental, medical, especially free radical (ROS) and damage of mitochondrial DNA; and some strategies of treatment, as well as promising rehabilitations associating with presbycusis.
Huang
Qi
Q
Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China.
Tang
Jianguo
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways / Q000503:physiopathology; D017626:Cochlear Nucleus / Q000503:physiopathology; D003142:Communication; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005829:Geniculate Bodies / Q000503:physiopathology; D006310:Hearing Aids; D006801:Humans; D011304:Presbycusis / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000534:rehabilitation; D011788:Quality of Life / Q000523:psychology; D012307:Risk Factors; D055815:Young Adult
Hear Res. 2007 Apr;226(1-2):194-202
16843623
Hum Mol Genet. 2008 Jan 15;17(2):159-69
17921507
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12523-8
16888038
Nat Med. 2003 Oct;9(10):1293-9
12949502
Audiol Neurootol. 2007;12(3):145-54
17259700
Braz J Otorhinolaryngol. 2009 Jul-Aug;75(4):573-8
19784428
Lancet. 2005 Sep 24-30;366(9491):1111-20
16182900
Prev Med. 2005 Feb;40(2):138-44
15533522
Nat Med. 2005 Mar;11(3):271-6
15711559
J Neurosci. 2003 Jul 9;23(14):6111-22
12853430
Ann N Y Acad Sci. 2002 Apr;959:508-16
11976223
Nature. 2007 Sep 6;449(7158):87-91
17805295
Nat Cell Biol. 2003 May;5(5):422-6
12717441
Hum Mutat. 2006 Oct;27(10):1007-16
16917933
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4084-8
10097167
Acta Otolaryngol. 2004 Mar;124(2):130-6
15072414
J Acoust Soc Am. 1990 Aug;88(2):813-20
2212307
Behav Brain Res. 2005 Jan 6;156(1):95-103
15474654
Genomics. 2000 Dec 1;70(2):171-80
11112345
J Acoust Soc Am. 2006 Feb;119(2):1143-55
16521775
Hear Res. 1997 Aug;110(1-2):147-54
9282897
J Occup Med. 1989 Dec;31(12):996
2614541
Am J Otol. 1988 Sep;9(5):376-82
3202126
Dev Biol. 2005 Apr 15;280(2):281-94
15882573
Hear Res. 2005 Nov;209(1-2):10-8
16039078
Postgrad Med J. 2006 Mar;82(965):166-71
16517797
J Am Acad Audiol. 2008 Apr;19(4):281-92; quiz 371
18795468
Arch Otolaryngol Head Neck Surg. 1999 Jun;125(6):654-9
10367922
Ear Hear. 2008 Aug;29(4):578-84
18469720
Curr Pharm Des. 2007;13(1):119-26
17266591
Acta Otolaryngol. 2001 Sep;121(6):666-72
11678164
Acta Otolaryngol. 1991;111(2):240-8
2068909
J Acoust Soc Am. 1991 Jul;90(1):175-81
1880286
Development. 2005 May;132(10):2377-88
15843406
Laryngoscope. 2009 Jun;119(6):1180-3
19301411
Laryngoscope. 2001 Mar;111(3):528-34
11224787
Arch Med Res. 2009 Jan;40(1):18-23
19064122
Ann Otol Rhinol Laryngol. 1993 Jan;102(1 Pt 2):1-16
8420477
Mutat Res. 2008 Apr 2;640(1-2):38-45
18242646
Lancet. 1986 Jan 18;1(8473):121-3
2867347
Scand Audiol. 1997;26(3):133-40
9309808
Arch Otolaryngol Head Neck Surg. 2007 Sep;133(9):929-33
17875861
Apoptosis. 2008 Nov;13(11):1303-21
18839313
Arch Otolaryngol Head Neck Surg. 2006 May;132(5):506-10
16702566
Prev Med. 2007 Feb;44(2):124-8
17157369
J Acoust Soc Am. 1988 Mar;83(3):859-95
3281988
Clin Otolaryngol. 2006 Apr;31(2):116-22
16620330
Acta Otolaryngol. 2009 Jan;129(1):36-44
18607930
Acta Otolaryngol Suppl. 1990;476:54-68
2087980
J Assoc Res Otolaryngol. 2005 Sep;6(3):234-43
15983726
Acta Otolaryngol Suppl. 2004 Mar;(551):26-30
15078073
Hear Res. 1990 Jun;46(1-2):113-45
2380120
Int J Audiol. 2006 Jul;45(7):367-81
16938795
J Gerontol. 1985 Sep;40(5):579-85
4031406
J Pathol. 2007 Jan;211(2):188-97
17200945
Ageing Res Rev. 2002 Jun;1(3):331-43
12067590
Methods Mol Biol. 2006;330:71-92
16846017
Acta Otolaryngol. 2006 Jan;126(1):10-4
16308248
Mol Ther. 2002 Jul;6(1):12-8
12095298
Curr Opin Otolaryngol Head Neck Surg. 2004 Oct;12(5):439-43
15377958
J Assoc Res Otolaryngol. 2003 Sep;4(3):353-62
14690053
Hear Res. 1998 Apr;118(1-2):101-13
9606065
Physiol Rev. 1998 Apr;78(2):547-81
9562038
Zhonghua Yi Xue Za Zhi. 2003 Sep 10;83(17):1517-20
14521734
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4333-8
10760300
Hear Res. 1997 Dec;114(1-2):75-82
9447921
Otol Neurotol. 2004 May;25(3):298-301
15129109
Ann Intern Med. 1990 Aug 1;113(3):188-94
2197909
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7
19901338
Audiology. 2001 Nov-Dec;40(6):313-21
11781044
Hear Res. 2010 Jun 1;264(1-2):98-107
19735708
Arch Otolaryngol Head Neck Surg. 2003 Oct;129(10):1041-6
14568784
Brain Res. 2006 May 26;1091(1):89-102
16631134
Acta Otolaryngol. 2001 Jan;121(2):140-2
11349765
Gerontology. 2010;56(2):123-8
19713692
Hear Res. 2010 Jun 1;264(1-2):41-7
19931608
Acta Otolaryngol Suppl. 2004 May;(552):16-24
15219042
J Assoc Res Otolaryngol. 2002 Dec;3(4):444-56
12486599
Exp Gerontol. 2003 Jan-Feb;38(1-2):87-94
12543265
J Am Geriatr Soc. 2005 Dec;53(12):2119-27
16398896
Laryngoscope. 2009 Jun;119(6):1184-9
19358252
Exp Gerontol. 2003 Mar;38(3):319-25
12581797
Audiol Neurootol. 2007;12(6):345-58
17664866
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13495-500
14593207
Ear Hear. 1997 Apr;18(2):114-20
9099560
Am J Otol. 1997 Jul;18(4):449-53
9233484
J Public Health Med. 2000 Dec;22(4):512-7
11192279
J Speech Lang Hear Res. 2005 Apr;48(2):473-81
15989405
Biochem Biophys Res Commun. 2007 Mar 30;355(1):117-21
17291455
Int J Audiol. 2003 Jul;42 Suppl 2:2S3-10
12918622
Hear Res. 2007 Apr;226(1-2):185-93
16870370
Hear Res. 2000 Mar;141(1-2):220-8
10713509
Acta Otolaryngol. 2005 Dec;125(12):1272-6
16303673
Science. 2005 Jul 15;309(5733):481-4
16020738
Nat Genet. 2003 Sep;35(1):21-3
12910270
Cell. 1999 Feb 5;96(3):437-46
10025409
Arch Phys Med Rehabil. 2006 Jun;87(6):757-63
16731209
J Otolaryngol Head Neck Surg. 2008 Aug;37(4):488-94
19128581
Int J Audiol. 2003 Jul;42 Suppl 2:2S92-101
12918635
Hear Res. 1990 Jul;46(3):201-10
2394633
J Acoust Soc Am. 2005 Aug;118(2):1089-100
16158663
Ear Hear. 2006 Jun;27(3):263-78
16672795
Hear Res. 2007 Apr;226(1-2):157-67
17113254
Arch Otolaryngol Head Neck Surg. 1997 Oct;123(10):1039-45
9339978
Arch Otolaryngol. 1964 Oct;80:369-82
14198699
JAMA. 2002 Nov 13;288(18):2271-81
12425704
Arch Neurol. 1995 Jun;52(6):626-34
7763213
Arch Otolaryngol Head Neck Surg. 2003 Mar;129(3):285-9
12622536
Osteoporos Int. 2005 Dec;16(12):1675-82
15883660
J Am Acad Audiol. 1997 Aug;8(4):269-76
9272749
J Neurosci. 2001 Jul 1;21(13):4712-20
11425898
Mol Ther. 2001 Jun;3(6):958-63
11407910
J Commun Disord. 2007 Jul-Aug;40(4):305-12
17433356
J Acoust Soc Am. 1998 Oct;104(4):2385-99
10491702
Nature. 2004 May 27;429(6990):417-23
15164064
Hear Res. 1997 Dec;114(1-2):83-92
9447922
Neurobiol Aging. 2007 Oct;28(10):1605-12
16920227
Ear Hear. 1990 Aug;11(4):247-56
2210098
Laryngoscope. 2005 Dec;115(12):2238-41
16369173
Genomics. 2002 Nov;80(5):461-4
12408962
Biochem Biophys Res Commun. 2004 Nov 26;324(4):1283-8
15504353