title: 'In vivo' optical approaches to angiogenesis imaging.
abstract: In recent years, molecular imaging gained significant importance in biomedical research. Optical imaging developed into a modality which enables the visualization and quantification of all kinds of cellular processes and cancerous cell growth in small animals. Novel gene reporter mice and cell lines and the development of targeted and cleavable fluorescent "smart" probes form a powerful imaging toolbox. The development of systems collecting tomographic bioluminescence and fluorescence data enabled even more spatial accuracy and more quantitative measurements. Here we describe various bioluminescent and fluorescent gene reporter models and probes that can be used to specifically image and quantify neovascularization or the angiogenic process itself.
authors.affiliation: Department of Endocrinology, Leiden University Medical Center, Building 1, C4-R86, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
authors.forename: T J A
authors.initials: TJ
authors.lastname: Snoeks
authors.forename: C W G M
authors.initials: CW
authors.lastname: Löwik
authors.forename: E L
authors.initials: EL
authors.lastname: Kaijzel
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes / Q000378:metabolism; D017930:Genes, Reporter; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D055620:Optical Phenomena
chemical_list: D005456:Fluorescent Dyes
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