title: Histopathological alterations and induction of hsp70 in ramshorn snail (Marisa cornuarietis) and zebrafish (Danio rerio) embryos after exposure to PtCl(2).
abstract: The platinum group metals (PGMs) platinum (Pt), palladium (Pd), and rhodium (Rh) are used in automobile catalytic converters, from which they have been emitted into the environment to an increasing degree during the last 20 years. Despite the bioavailability of these metals to plants and animals, studies determining the effects of PGMs on organisms are extremely rare. In the present study, effects of various concentrations of PtCl(2) (0.1, 1, 10, 50 and 100 microg/L) were investigated with respect to the induction of hsp70 and histopathological alterations in the zebrafish, Danio rerio and the ramshorn snail, Marisa cornuarietis. Histopathological investigations revealed effects of Pt on both species, which varied between slight and strong cellular reactions, depending on the PtCl(2) concentration. The hsp70 level in M. cornuarietis did not show an increase following Pt exposure whereas it was significantly elevated at 100 micorg/L PtCl(2) in D. rerio.
authors.affiliation: Animal Physiological Ecology Department, University of Tübingen, Konrad-Adenauer-Str. 20, 72072 Tübingen, Germany. raphaela.osterauer@gmx.de
authors.forename: Raphaela
authors.initials: R
authors.lastname: Osterauer
authors.forename: Heinz-R
authors.initials: HR
authors.lastname: Köhler
authors.forename: Rita
authors.initials: R
authors.lastname: Triebskorn
mesh_terms: D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D005393:Fish Diseases / Q000139:chemically induced / Q000378:metabolism; D005880:Gills / Q000378:metabolism / Q000473:pathology*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D017671:Platinum Compounds / Q000378:metabolism / Q000633:toxicity*; D012908:Snails / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D017671:Platinum Compounds; D014874:Water Pollutants, Chemical; C030173:platinum chloride