title: Effect of statins on estrogen and androgen levels in postmenopausal women treated with estradiol.
abstract: OBJECTIVE
  A considerable number of postmenopausal women who receive estrogen therapy are also treated for hypercholesterolemia with cholesterol-lowering statins. Statins and steroid hormones can compete for the same steroid-metabolizing enzymes. We investigated whether long-term administration of statins had an effect on serum estrogen and androgen levels in postmenopausal women receiving and not receiving oral estrogen therapy.
  
  
  METHODS
  A subgroup analysis from the Estrogen in the Prevention of Atherosclerosis Trial, a randomized, double-blind, placebo-controlled trial, was performed. A total of 222 women were randomized to receive either placebo or 1 mg of oral micronized 17β-estradiol daily for 2 years. In both the placebo and treatment groups, participants with low density lipoprotein cholesterol levels >160 mg/dl were treated with statins. Blood samples were obtained at baseline and every 6 months during the trial. Serum levels of dehydroepiandrosterone, androstenedione, testosterone, estrone and 17β-estradiol were measured by radioimmunoassay.
  
  
  RESULTS
  Among 86 placebo- and 90 estradiol-treated subjects with baseline and on-trial hormone measurements, no significant differences were observed between the statin-free and statin-treated groups in mean changes from baseline to on-trial levels in any of the androgens or estrogens, whether or not the postmenopausal women were treated with estrogen.
  
  
  CONCLUSIONS
  The results suggest that estrogen therapy and statins can be used simultaneously with no deleterious effects on circulating hormone levels.
authors.affiliation: Departments of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA 90093, USA.
authors.forename: A
authors.initials: A
authors.lastname: Peck
authors.forename: S
authors.initials: S
authors.lastname: Chaikittisilpa
authors.forename: R
authors.initials: R
authors.lastname: Mirzaei
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: W J
authors.initials: WJ
authors.lastname: Mack
authors.forename: H N
authors.initials: HN
authors.lastname: Hodis
authors.forename: F Z
authors.initials: FZ
authors.lastname: Stanczyk
mesh_terms: D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D004958:Estradiol / Q000627:therapeutic use*; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008875:Middle Aged; D017698:Postmenopause
chemical_list: D008078:Cholesterol, LDL; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D004958:Estradiol
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