[Chemotherapy and women fertility preservation].
Agressive chemotherapy can lead to premature ovarian failure and loss of fertility in women and children. Embryo cryopreservation is an established clinical procedure of fertility preservation but with several limitations. Others options are available. Cryopreservation ovarian cortex tissu have to be suggested in case of high gonadotoxic treatment. It doesn't require puberty and delay in initiation of chemotherapy. The first birth in France after orthotopic graft of ovarian tissu thawed have been recently described with a promising process. Oocyte cryopreservation is available for women without partner but the experience is limited. Gonadotrophin-releasing hormone (GnRH) agonist therapy as ovarian protectants seem interesting. Follicular growth and maturation in vitro are still experimental.
Gauthier
Tristan
T
CHU Dupuytren, hôpital Mère-Enfant, service gynécologie-obstétrique, avenue Dominique-Larrey, 87000 Limoges, France. gauthiertristan@yahoo.fr
Piver
Pascal
P
Durand
Lise-Marie
LM
Donadel
Lorène
L
Pech
Jean-Christophe
JC
Roux
Christophe
C
Aubard
Yves
Y
D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced* / Q000517:prevention & control*
D000970:Antineoplastic Agents