DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history.
The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.
Pop-Busui
Rodica
R
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. rpbusui@umich.edu
Herman
William H
WH
Feldman
Eva L
EL
Low
Phillip A
PA
Martin
Catherine L
CL
Cleary
Patricia A
PA
Waberski
Barbara H
BH
Lachin
John M
JM
Albers
James W
JW
D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000628:therapy; D009202:Cardiomyopathies / Q000209:etiology / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D003929:Diabetic Neuropathies / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D016032:Randomized Controlled Trials as Topic
D007004:Hypoglycemic Agents; D007328:Insulin
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