In vitro studies on a class of quinoline containing histamine H3 antagonists.
A series of quinoline containing histamine H(3) antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring.
Liu
Huaqing
H
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6123, USA. huaqing.liu@abbott.com
Altenbach
Robert J
RJ
Diaz
Gilbert J
GJ
Manelli
Arlene M
AM
Martin
Ruth L
RL
Miller
Thomas R
TR
Esbenshade
Timothy A
TA
Brioni
Jorge D
JD
Cowart
Marlon D
MD
D000818:Animals; D054828:Histamine H3 Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
D054828:Histamine H3 Antagonists; D011804:Quinolines