Setting up presynaptic structures at specific positions.
Precise formation of presynaptic structures at specific loci is critical for correctly wiring neuronal circuits. Recent findings have gradually revealed how essential cues from different sources inform the axon to define the presynaptic domain and to choose its postsynaptic target. Here, we review key molecular regulators which mediate instructive or repellent signals from multiple sources including the target cells, local guidepost cells, and distal guiding tissues.
Ou
Chan-Yen
CY
Department of Biology, Howard Hughes Medical Institute, Stanford University, 385 Serra Mall, CA 94305, USA.
Shen
Kang
K
D000818:Animals; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D009419:Nerve Tissue Proteins
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