title: Frequency and rate of pilin antigenic variation of Neisseria meningitidis.
abstract: The rates of pilin antigenic variation (Av) of two strains of Neisseria meningitidis were determined using an unbiased DNA sequencing assay. Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18.
authors.affiliation: Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.
authors.forename: R Allen
authors.initials: RA
authors.lastname: Helm
authors.forename: H Steven
authors.initials: HS
authors.lastname: Seifert
mesh_terms: D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D036781:Fimbriae Proteins / Q000235:genetics / Q000276:immunology*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000276:immunology; D009345:Neisseria meningitidis / Q000235:genetics / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D036781:Fimbriae Proteins
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