title: Progenitor cell number is correlated to physical performance in obese children and young adolescents.
abstract: Juvenile obesity is associated with cardiovascular risk factors. In adults, cardiovascular risk factors and obesity are associated with a decreased number of endothelial progenitor cells. Higher physical fitness correlates with a lower cardiovascular morbidity and increased endothelial progenitor cells.
  
  
  METHODS
  CD34 positive, KDR/CD34, CD133/CD34, and CD117/CD34 double positive progenitor cells were measured in 24 obese children and adolescents - 15 female; age: 12.5 plus or minus 2.1 years, body mass index standard deviation score: 2.5 plus or minus 0.5, waist: 88.6 plus or minus 15.0 centimetre, body fat: 24.6 plus or minus 2.2% - participating in the CHILT III programme. Percentage body fat was assessed by skinfold thickness. Peak of oxygen uptake and the respiratory quotient were determined by spiroergometry.
  
  
  RESULTS
  No gender differences were found. CD34 positive and CD117 positive/CD34 positive cells correlated with maximum relative watt performance, r is equal to 0.429 and 0.462; p-value less than 0.05. The peak of oxygen uptake correlated with CD34 positive and CD133 positive/CD34 positive cells, r is equal to 0.458 and 0.456; p-value less than 0.05, while no correlations were found between parameters of weight, body composition, and respiratory quotient with progenitor cells.
  
  
  CONCLUSIONS
  A higher physical fitness, but not less body fat or body mass index is associated with a higher number of endothelial progenitor cells. These results support the hypothesis that physical fitness and cardiovascular risk in high-risk populations are inversely related. Further research is warranted to clarify the strength of this association and longitudinal effects of a comprehensive obesity programme.
authors.affiliation: Institute of Movement and Neurosciences, German Sport University Cologne, 50933 Cologne, Germany. C.Arnold@dshs-koeln.de
authors.forename: Christiane
authors.initials: C
authors.lastname: Arnold
authors.forename: Daniel
authors.initials: D
authors.lastname: Wenta
authors.forename: Jochen
authors.initials: J
authors.lastname: Müller-Ehmsen
authors.forename: Narayanswami
authors.initials: N
authors.lastname: Sreeram
authors.forename: Christine
authors.initials: C
authors.lastname: Graf
mesh_terms: D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D002452:Cell Count; D002648:Child; D015331:Cohort Studies; D042783:Endothelial Cells; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D013147:Spirometry; D013234:Stem Cells