title: Imaging myocardial metabolic remodeling.
abstract: Myocardial metabolic remodeling is the process in which the heart loses its ability to utilize different substrates, becoming dependent primarily on the metabolism of a single substrate such as glucose or fatty acids for energy production. Myocardial metabolic remodeling is central to the pathogenesis of a variety of cardiac disease processes such as left ventricular hypertrophy, myocardial ischemia, and diabetic cardiomyopathy. As a consequence, there is a growing demand for accurate noninvasive imaging approaches of various aspects of myocardial substrate metabolism that can be performed in both humans and small-animal models of disease, facilitating the crosstalk between the bedside and the bench and leading to improved patient management paradigms. SPECT, PET, and MR spectroscopy are the most commonly used imaging techniques. Discussed in this review are the strengths and weaknesses of these various imaging methods and how they are furthering our understanding of the role of myocardial remodeling in cardiovascular disease. In addition, the role of ultrasound to detect the inflammatory response to myocardial ischemia will be discussed.
authors.affiliation: Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA. Groplerr@mir.wustl.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gropler
authors.forename: Rob S B
authors.initials: RS
authors.lastname: Beanlands
authors.forename: Vasken
authors.initials: V
authors.lastname: Dilsizian
authors.forename: E Douglas
authors.initials: ED
authors.lastname: Lewandowski
authors.forename: Flordeliza S
authors.initials: FS
authors.lastname: Villanueva
authors.forename: Maria Cecilia
authors.initials: MC
authors.lastname: Ziadi
mesh_terms: D000818:Animals; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006801:Humans; D007249:Inflammation; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D049268:Positron-Emission Tomography / Q000379:methods*; D013667:Technetium / Q000494:pharmacology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18; D013667:Technetium; D005947:Glucose
references.citation: Circulation. 2003 Sep 9;108(10):1208-13
references.pmid: 12939208
references.citation: Circulation. 1998 Feb 10;97(5):473-83
references.pmid: 9490243
references.citation: J Am Coll Cardiol. 2002 Apr 3;39(7):1151-8
references.pmid: 11923039
references.citation: J Am Coll Cardiol. 1995 Oct;26(4):870-8
references.pmid: 7560611
references.citation: N Engl J Med. 1990 Dec 6;323(23):1593-600
references.pmid: 2233948
references.citation: J Nucl Med. 2008 Dec;49(12):1986-91
references.pmid: 18997035
references.citation: Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E714-8
references.pmid: 18628354
references.citation: Circulation. 2000 Nov 28;102(22):2745-50
references.pmid: 11094042
references.citation: Biochem Soc Trans. 2003 Feb;31(Pt 1):228-31
references.pmid: 12546691
references.citation: Circulation. 2001 Oct 23;104(17):2107-12
references.pmid: 11673354
references.citation: J Clin Invest. 2002 Jan;109(1):121-30
references.pmid: 11781357
references.citation: Circulation. 2007 Jan 23;115(3):345-52
references.pmid: 17210843
references.citation: JACC Cardiovasc Imaging. 2009 Sep;2(9):1060-8
references.pmid: 19761983
references.citation: Circulation. 2000 Aug 1;102(5):531-8
references.pmid: 10920065
references.citation: Am Heart J. 1991 Sep;122(3 Pt 1):795-801
references.pmid: 1877457
references.citation: Am J Cardiol. 1994 Mar 15;73(8):527-33
references.pmid: 8147295
references.citation: Am J Physiol. 1990 Sep;259(3 Pt 2):H987-95
references.pmid: 1975735
references.citation: J Am Coll Cardiol. 1992 Sep;20(3):559-65
references.pmid: 1512333
references.citation: Circulation. 2002 Apr 16;105(15):1764-7
references.pmid: 11956115
references.citation: Circulation. 2005 Oct 4;112(14):2169-74
references.pmid: 16186423
references.citation: Am J Physiol Cell Physiol. 2000 Dec;279(6):C1704-9
references.pmid: 11078684
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12051-6
references.pmid: 18689683
references.citation: J Nucl Med. 1996 Oct;37(10):1631-6
references.pmid: 8862297
references.citation: J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9
references.pmid: 19022158
references.citation: N Engl J Med. 2001 Jun 14;344(24):1823-31
references.pmid: 11407343
references.citation: Circ Res. 2009 Mar 27;104(6):805-12
references.pmid: 19213957
references.citation: J Am Coll Cardiol. 2001 Dec;38(7):1888-94
references.pmid: 11738290
references.citation: Circ Res. 1994 Feb;74(2):336-43
references.pmid: 7507416
references.citation: Biotechnol Bioeng. 2005 Dec 20;92(6):780-8
references.pmid: 16121392
references.citation: Circulation. 1995 Dec 15;92(12):3436-44
references.pmid: 8521565
references.citation: J Nucl Med. 2007 Dec;48(12):2046-55
references.pmid: 18056334
references.citation: Proc Natl Acad Sci U S A. 1987 Jun;84(12):4283-7
references.pmid: 3473502
references.citation: J Nucl Med. 2007 Jun;48(6):955-64
references.pmid: 17536107
references.citation: Circulation. 2001 May 29;103(21):2624-30
references.pmid: 11382734
references.citation: Kidney Int. 2004 Aug;66(2):811-9
references.pmid: 15253738
references.citation: Circulation. 2002 Jan 22;105(3):367-72
references.pmid: 11804994
references.citation: J Am Coll Cardiol. 2008 Jan 15;51(2):146-8
references.pmid: 18191739
references.citation: Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S42-8
references.pmid: 18641606
references.citation: J Exp Med. 1995 Feb 1;181(2):669-75
references.pmid: 7530761
references.citation: Am J Hypertens. 2001 Jun;14(6 Pt 2):44S-54S
references.pmid: 11411765
references.citation: Cardiovasc Res. 2009 Feb 15;81(3):412-9
references.pmid: 18987051
references.citation: J Am Coll Cardiol. 2008 Jan 15;51(2):139-45
references.pmid: 18191738
references.citation: Circulation. 2002 Feb 12;105(6):759-65
references.pmid: 11839634
references.citation: Am J Physiol Cell Physiol. 2007 May;292(5):C1880-6
references.pmid: 17229809
references.citation: J Nucl Med. 2010 Apr;51(4):567-74
references.pmid: 20237039
references.citation: J Nucl Med. 1996 Oct;37(10):1723-30
references.pmid: 8862319
references.citation: Echocardiography. 2002 Apr;19(3):229-40
references.pmid: 12022933
references.citation: Circulation. 1998 Mar 10;97(9):843-50
references.pmid: 9521332
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19773-7
references.pmid: 18056642
references.citation: Circulation. 2005 Jun 21;111(24):3248-54
references.pmid: 15956135
references.citation: Circulation. 1998 Jun 30;97(25):2536-42
references.pmid: 9657474
references.citation: J Cell Biol. 1992 May;117(4):895-902
references.pmid: 1374413
references.citation: J Nucl Med. 2008 Aug;49(8):1320-7
references.pmid: 18632819
references.citation: Circulation. 2007 Sep 4;116(10):1170-5
references.pmid: 17698735
references.citation: Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H361-7
references.pmid: 10899076
references.citation: Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S26-32
references.pmid: 18641604
references.citation: Circulation. 2008 Jul 15;118(3):291-308
references.pmid: 18625905
references.citation: Circ Cardiovasc Imaging. 2009 Nov;2(6):485-91
references.pmid: 19920047
references.citation: N Engl J Med. 1990 Jul 19;323(3):141-6
references.pmid: 2362606
references.citation: Curr Probl Cardiol. 2007 Jul;32(7):375-410
references.pmid: 17560992
references.citation: J Am Coll Cardiol. 2007 Nov 13;50(20):2002-12
references.pmid: 17996568
references.citation: J Nucl Med. 1995 Feb;36(2):176-9
references.pmid: 7830109
references.citation: JACC Cardiovasc Imaging. 2009 Jan;2(1):87-96
references.pmid: 19356540
references.citation: Circulation. 2007 Apr 17;115(15):2033-41
references.pmid: 17404155
references.citation: J Nucl Cardiol. 2001 Jan-Feb;8(1):75-88
references.pmid: 11182712
references.citation: J Clin Invest. 2007 Dec;117(12):3930-9
references.pmid: 18037994
references.citation: N Engl J Med. 1986 Apr 3;314(14):884-8
references.pmid: 3485252
references.citation: J Nucl Cardiol. 2002 Jul-Aug;9(4):419-28
references.pmid: 12161719
references.citation: J Magn Reson Imaging. 1992 Nov-Dec;2(6):711-9
references.pmid: 1446116
references.citation: Biophys J. 2001 Mar;80(3):1547-56
references.pmid: 11222315
references.citation: Circ Res. 1994 Jun;74(6):1157-65
references.pmid: 8187282
references.citation: J Mol Cell Cardiol. 2008 Feb;44(2):315-22
references.pmid: 18155232
references.citation: Circulation. 1992 May;85(5):1842-56
references.pmid: 1572040
references.citation: Circulation. 2009 Apr 21;119(15):2069-77
references.pmid: 19349323
references.citation: J Am Coll Cardiol. 1998 Nov;32(5):1426-32
references.pmid: 9809958
references.citation: Magn Reson Med. 2009 May;61(5):1007-14
references.pmid: 19253408
references.citation: Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96
references.pmid: 18487436
references.citation: J Nucl Med. 1990 Nov;31(11):1749-56
references.pmid: 2230987
references.citation: Radiology. 1991 Oct;181(1):67-75
references.pmid: 1887057
references.citation: J Nucl Med. 1978 Dec;19(12):1311-9
references.pmid: 104018
references.citation: Circulation. 2006 Sep 12;114(11):1151-8
references.pmid: 16952984
references.citation: J Nucl Cardiol. 2007 May-Jun;14(3):354-65
references.pmid: 17556170
references.citation: J Am Coll Cardiol. 2010 Jul 20;56(4):290-9
references.pmid: 20633821