Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide.
A 73-year-old man was admitted with complaints of a 2-month history of generalized weakness and numbness. Laboratory examination revealed hypercalcemia, metabolic alkalosis, and kidney injury, similar to the traditional milk-alkali syndrome. The clinical history and the response to therapy indicated that alphacalcidol and thiazide taken daily were the cause. Recently, it has been recommended the term "milk-alkali syndrome" be replaced by "calcium-alkali syndrome", which broadens the definition of the condition. This case suggests that the calcium-alkali syndrome can occur without calcium and alkali, but rather with alphacalcidol and a thiazide diuretic.
Satoh
Fumie
F
Department of Nephrology, Tokyo Medical and Dental University.
Okado
Tomokazu
T
Iwamoto
Mari
M
Akita
Wataru
W
Wakabayashi
Mai
M
Ohta
Akihito
A
Sohara
Eisei
E
Noda
Yumi
Y
Rai
Tatemitsu
T
Uchida
Shinichi
S
Sasaki
Sei
S
D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D001774:Blood Chemical Analysis; D003131:Combined Modality Therapy; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects*; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000009:adverse effects*; D006934:Hypercalcemia / Q000139:chemically induced* / Q000175:diagnosis; D007677:Kidney Function Tests; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D006887:Hydroxycholecalciferols; D006852:Hydrochlorothiazide; C008088:alfacalcidol