Selective binding of small molecules to DNA: application and perspectives.
More and more researchers are interested in DNA binders with sequence selectivity which may be developed to potential drugs. In this paper, we mainly review the compounds that selectively bind to special bases or sequences such as AT and GC-rich sequences. The selective binding of them to DNA sequences could affect the interactions of transcription factors with their target sequences in DNA. Furthermore, the design and effectiveness of sequence-selective DNA binding drugs are discussed. At last we put forward the some current challenges and solution in developing targeting anticancer drugs binding to specific oncogene.
Wang
Bochu
B
Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China. wangbc2000@126.com
Tan
Jun
J
Zhu
Liancai
L
D001483:Base Sequence; D001665:Binding Sites; D001667:Binding, Competitive; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism
D004364:Pharmaceutical Preparations; D014157:Transcription Factors; D004247:DNA