Intrahepatic sarcomatoid cholangiocarcinoma.
Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma. The patient had early onset disease recurrence within 5 weeks of surgery. Here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma. The patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery.
Malhotra
Shalini
S
Department of Histopathology, Nottingham University Hospitals, Queens Medical Centre Campus, University of Nottingham, NG7 2UH Nottingham, UK.
Wood
Joanna
J
Mansy
Talal
T
Singh
Rajeev
R
Zaitoun
Abed
A
Madhusudan
Srinivasan
S
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