title: G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve.
abstract: The growth differential factor-9 (GDF-9) gene, an oocyte-specific factor, was screened in 106 Chinese women with diminished ovarian reserve (DOR), and three single-nucleotide polymorphisms, c.G169A, c.C447T and c.G546A, were detected. We found GDF-9 c.G546A, but not c.G169A or c.C447T, to be correlated with the poor ovarian stimulation and in vitro fertilization outcomes in women with DOR.
authors.affiliation: Department of Reproductive Endocrinology, Zhejiang Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Yan-Ting
authors.initials: YT
authors.lastname: Wu
authors.forename: Min-Yue
authors.initials: MY
authors.lastname: Dong
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Sheng
authors.forename: Peter C K
authors.initials: PC
authors.lastname: Leung
authors.forename: He-Feng
authors.initials: HF
authors.lastname: Huang
mesh_terms: D000328:Adult; D002452:Cell Count; D005260:Female; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease; D055429:Growth Differentiation Factor 9 / Q000235:genetics*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D020125:Mutation, Missense / Q000502:physiology; D010053:Ovary / Q000473:pathology; D010062:Ovulation Induction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D055429:Growth Differentiation Factor 9