[The role of AGEs and ROS in atherosclerosis].
Advanced glycation end products (AGEs) are among the "newcomers" of metabolic research during the last 2-3 decades. Also known as Maillard products, they have belonged to the everyday life of food research for a long time, but their role in the development of diabetes and cardiovascular complications has been suggested only recently. Even though multiple studies have recently dealt with the role of AGEs and their receptors in mediating pathomechanisms, we are still far from understanding them completely and maybe even farther from developing effective therapeutic approaches. Nevertheless, the present article attempts to offer an overview of known associations between AGEs and vascular complications, in order to draw attention to a less known subject--the AGEs--and, maybe, to stimulate further research in this very exciting field.
Stirban
Alin
A
Diabetesklinik, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany. stirban@web.de
D050197:Atherosclerosis / Q000276:immunology*; D017127:Glycation End Products, Advanced / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species
Arterioscler Thromb Vasc Biol. 2004 May;24(5):816-23
14976002
Diabetologia. 2002 Jun;45(6):867-76
12107731
Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9441-5
7937786
Diabetes Care. 2003 May;26(5):1589-96
12716823
Int J Clin Pract Suppl. 2002 Jul;(129):51-8
12166608
Nat Med. 2003 Mar;9(3):294-9
12592403
Diabetes Care. 2005 Oct;28(10):2465-71
16186281
Adv Exp Med Biol. 2005;561:135-56
16438296
Circulation. 2001 Nov 27;104(22):2673-8
11723017
FEBS Lett. 1995 Jul 17;368(2):225-9
7628610
Eur J Pharmacol. 1999 Jul 2;376(1-2):17-22
10440084
Horm Metab Res. 2008 Dec;40(12):896-900
18792885
Diabetes Obes Metab. 2007 May;9(3):233-45
17391149
Diabetes Metab. 2001 Sep;27(4 Pt 1):436-47
11547217
Diabetes Care. 2007 Oct;30(10):2514-6
17630265
N Engl J Med. 2005 Dec 22;353(25):2643-53
16371630
FASEB J. 1999 Jan;13(1):23-30
9872926
Circulation. 2004 Jul 20;110(3):285-91
15249511
Diabete Metab. 1992 Jul-Aug;18(4):264-71
1459313
Diabetes. 2004 Jul;53(7):1813-23
15220206
Diabetes Metab Res Rev. 2002 May-Jun;18(3):224-37
12112941
Diabetologia. 2003 Apr;46(4):556-66
12739028
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8555-60
12805564
Am J Kidney Dis. 2003 Sep;42(3):532-8
12955681
Clin Sci (Lond). 2005 Jul;109(1):83-95
15755259
Diabetes Care. 1996 Mar;19(3):257-67
8742574
Sleep. 2006 Mar;29(3):329-33
16553018
Diabetes. 2002 Jul;51(7):2082-9
12086936
Science. 1966 Jan 14;151(3707):209-10
5907911
Curr Pharm Des. 2005;11(18):2279-99
16022668
Diabetes Care. 2007 Oct;30(10):2579-82
17496238
N Engl J Med. 2003 Jun 5;348(23):2294-303
12788993
Atherosclerosis. 2000 Jun;150(2):299-308
10856522
Nephrol Dial Transplant. 1996;11 Suppl 5:27-30
9044303
Atherosclerosis. 2003 Jun;168(2):213-20
12801603
Atherosclerosis. 2002 Aug;163(2):303-11
12052477
Proc Natl Acad Sci U S A. 1979 Jan;76(1):333-7
218198
J Am Soc Nephrol. 2003 Mar;14(3):728-31
12595509
Diabetes. 2005 Aug;54(8):2314-9
16046296
J Hypertens. 2005 Aug;23(8):1565-73
16003184
Diabetes. 1991 Mar;40(3):377-84
1847886
Diabetes. 1985 Sep;34(9):938-41
4029512
Diabetes Care. 2006 Sep;29(9):2064-71
16936154
J Clin Invest. 1991 Feb;87(2):432-8
1991829
J Hum Hypertens. 2003 Apr;17(4):265-70
12692571
Ann N Y Acad Sci. 2005 Jun;1043:461-6
16037267
Diabetes. 2003 Nov;52(11):2805-13
14578300
Microvasc Res. 2005 Nov;70(3):137-41
16271939
Ann N Y Acad Sci. 2008 Apr;1126:173-6
18448812