title: Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study.
abstract: The authors present preliminary results from a pilot study on patterns of brain injury associated with incident major depression after traumatic brain injury (TBI). Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between 10 subjects with incident major depression post-TBI and seven TBI patients without major depression. TBI-depressed participants performed poorly on tests of frontotemporal functioning, had lower choline/creatine and N-acetylaspartate/creatine ratios in the right basal ganglia and had lower regional brain volumes in the right frontal, left occipital, and temporal lobes. The results suggest a possible role of frontotemporal lobe and basal ganglia pathology in depression after TBI.
authors.affiliation: Division of Geriatric Psychiatry & Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. vrao@jhmi.edu
authors.forename: Vani
authors.initials: V
authors.lastname: Rao
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Munro
authors.forename: Paul
authors.initials: P
authors.lastname: Rosenberg
authors.forename: Julianna
authors.initials: J
authors.lastname: Ward
authors.forename: Melaine
authors.initials: M
authors.lastname: Bertrand
authors.forename: Mahaveer
authors.initials: M
authors.lastname: Degoankar
authors.forename: Alena
authors.initials: A
authors.lastname: Horská
authors.forename: Dzung
authors.initials: D
authors.lastname: Pham
authors.forename: David M
authors.initials: DM
authors.lastname: Yousem
authors.forename: Peter B
authors.initials: PB
authors.lastname: Barker
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000378:metabolism / Q000473:pathology; D003401:Creatine / Q000378:metabolism; D003865:Major Depressive Disorder / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size; D010865:Pilot Projects; D013997:Time Factors
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline