Controversy of corticosteroids in septic shock.
The mortality rate of septic shock remains high. The guidelines of the Surviving Sepsis Campaign were published in 2004 and were revised in 2008. Steroid therapy is prominent in the guidelines but remains controversial. In this review, steroid therapy for septic shock is discussed with various landmark papers.
Miyashita
Masao
M
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School. miyashit@nms.ac.jp
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000266:history / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006293:Health Promotion; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D017410:Practice Guidelines as Topic; D012772:Shock, Septic / Q000188:drug therapy* / Q000266:history / Q000401:mortality; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones