title: Surgical management of pancreatic necrosis: towards lesser and later.
abstract: OBJECTIVE
  Our aim was to determine the overall success rate and survival rate with respect to the timing of intervention in the management of pancreatic necrosis. The use of minimally invasive pancreatic necrosectomy was also examined.
  
  
  METHODS
  This was a retrospective study carried out in a tertiary referral hospital. The subjects were all patients who suffered from acute pancreatic necrosis with emergency interventions from January 2001 to December 2007. For outcome measures, special emphasis was placed on the overall success rate and survival rate with respect to the timing of intervention. The success rate of percutaneous pancreatic necrosectomy (PCPN) was examined.
  
  
  RESULTS
  A total of 26 patients with pancreatic necrosis were studied. The overall mortality rate was 26.9% and the rate was significantly higher in those patients who had earlier intervention (before 6 weeks). Eleven patients had PCPN. There were 2 failures due to PCPN in the early phase; 2 had partial success, while the procedure was completely successful to remove all the necrotic tissues in the other 7 patients.
  
  
  CONCLUSIONS
  With a multidisciplinary approach, particularly with sophisticated intensive care, most patients with pancreatic necrosis can survive the initial phase. Open surgery should be limited to simple drainage and laparostomy to relieve the abdominal tension. Active intervention preferably should be delayed until the necrosis has become walled off, when a variety of minimally invasive maneuvers, notably percutaneous necrosectomy, can be offered to remove the debris. The surgical management of pancreatic necrosis should change towards a strategy of "lesser and later".
authors.affiliation: Department of Surgery, Block H10, Queen Elizabeth Hospital, 33, Gascoigne Road, Kowloon, Hong Kong. qehsurg@ha.org.hk
authors.forename: Moon-Tong
authors.initials: MT
authors.lastname: Cheung
authors.forename: Wing-Hong
authors.initials: WH
authors.lastname: Li
authors.forename: Philip Chong-Hei
authors.initials: PC
authors.lastname: Kwok
authors.forename: Jeffrey Kam-Fai
authors.initials: JK
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000000981:diagnostic imaging / Q000601:surgery*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome