[LDL-cholesterol levels in a series of HIV-infected patients].
OBJECTIVE
To analyse the prevalence of HIV-infected patients who do not reach their target LDL-cholesterol (LDL-C) levels.


METHODS
Multicenter, cross-sectional study of all HIV-infected patients on regular follow-up in 5 hospitals in the province of Malaga (March-August/07). They were classified depending on their target LDL-C levels (NCEP): group A:<160mg/dl, if </=1 cardiovascular risk factor (CVRF); group B: <130mg/dl, if >/=2 CVRF; group C: <100mg/dl, if cardiovascular disease or equivalents or CVR at 10 years >20%). A comparison between patients reaching their target LDL-C levels and those not reaching them was done. Statistic program: SPSS.


RESULTS
Of 1019 included patients, 232 (22.8%) did not reach their target LDL-C levels. There were 693 patients in Group A, 163 in Group B, and 153 in Group C (6.6%, 53.3 % and 65.0% respectively (p<0.05)) who did not reach their target LDL-C. Factors associated with LDL-C levels higher than target were: obesity (OR=1.98; 95%CI: 1.14-3.46; p=0.01), time on antiretroviral therapy (for each 2 years OR=1.92; 95%CI: 1.85-1.99; p=0.02), and being included in Groups B and C (OR=16.9; 95%CI: 10.8-26.6; p=0.00001).


CONCLUSIONS
More than 20% of the patients in this cohort did not reach their target LDL-C levels. Factors associated with high LDL-C levels were central obesity, time on antiretroviral therapy and being included in Groups B and C.
Gallego
Marisa
M
Hospital Virgen de la Victoria, Málaga, España.
Palacios
Rosario
R
Olalla
Julián
J
Orihuela
Francisco
F
Roldán
Juan
J
Santos
Jesús
J
Grana
Mariela
M
D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D008078:Cholesterol, LDL