title: Driving drug discovery: the fundamental role of academic labs.
abstract: Academic labs have been responsible for virtually all of the basic science discoveries that translate into the discovery and development of innovative new medicines. There is a growing concern that large pharmaceutical and biotechnology companies are not able to sustain research pipelines that bring new compounds into drug development that translate into innovative new medicines, especially in areas with high unmet medical need. To address the needs of patients, caregivers, and society, academic labs have played and can continue to play an important role at one or more stages in the development of innovative medicines, both directly and through collaborations with researchers in pharmaceutical and biotechnology companies. Collaboration is in the best interests of patients and society if it accelerates the translation of basic science discoveries to new medicines that address unmet medical needs.
authors.affiliation: Institute for Neurodegenerative Diseases and Departments of Neurology and Bioengineering and Therapeutic Sciences, University of California San Francisco Schools of Medicine and Pharmacy, San Francisco, CA 94143, USA. msilber@ind.ucsf.edu
authors.forename: B Michael
authors.initials: BM
authors.lastname: Silber
mesh_terms: D000046:Academic Medical Centers; D035843:Biomedical Research / Q000639:trends*; D055808:Drug Discovery / Q000639:trends*; D004345:Drug Industry / Q000458:organization & administration; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis; D013678:Technology, Pharmaceutical / Q000379:methods*; D014495:Universities
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D004364:Pharmaceutical Preparations