Seronegative HIV-1 infection: a review of the literature.
HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.
Spivak
Adam M
AM
Johns Hopkins School of Medicine, Division of Infectious Diseases, Baltimore, Maryland 21287, USA.
Sydnor
Emily R M
ER
Blankson
Joel N
JN
Gallant
Joel E
JE
D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D015483:HIV Antibodies / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D055815:Young Adult
D015483:HIV Antibodies