Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7.
A new titanocenyl amide containing flavone as pendant group has been synthesized by reaction of titanocenyl carboxylic acid chloride and 7-Aminoflavone and structurally characterized by spectroscopic methods. This species and eight previously synthesized titanocenyl amide complexes have been tested in breast adenocarcinoma cancer cell line, MCF-7. The functionalization of titanocene dichloride with amides enhances the cytotoxic activity in MCF-7. Two sets of titanocenyl amides can be identified, with IC(50) <100 muM and IC(50)>100 muM. The most cytotoxic species is Cp(CpCO-NH-C(6)H(4)-(CH(2))(2)CH(3))TiCl(2) with an IC(50) of 24(2) muM, followed by Cp(CpCO-NH-C(6)H(4)-Br)TiCl(2), IC(50) of 46(4) muM and Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2), IC(50) of 49(6) muM. There is no correlation between the nature of the para substituent on the phenyl ring and the cytotoxic properties on MCF-7 cell line.
Gao
Li Ming
LM
Department of Chemistry, University of Puerto Rico, P.O. Box 9019, Mayagüez, PR 00681, USA.
Meléndez
Enrique
E
Anticancer Drugs. 2007 Mar;18(3):317-21
17264765
Eur J Clin Pharmacol. 1994;47(1):1-16
7988618
Anticancer Drugs. 2007 Mar;18(3):311-5
17264764
Angew Chem Int Ed Engl. 1979 Jun;18(6):477-8
111586
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
6606682
Inorg Chem. 2010 Feb 15;49(4):1292-4
20055428
Chemistry. 2008;14(14):4160-3
18384037
Toxicol In Vitro. 2008 Mar;22(2):531-4
17981007
Met Ions Biol Syst. 2004;42:353-84
15206108
J Immunol Methods. 1986 May 22;89(2):271-7
3486233
Drug Metab Dispos. 2009 Mar;37(3):629-34
19074529
Apoptosis. 2006 Jul;11(7):1205-14
16699961
Curr Med Chem. 2000 Dec;7(12):1289-303
11032972
Crit Rev Oncol Hematol. 2002 Jun;42(3):309-15
12050022
Anticancer Agents Med Chem. 2009 Oct;9(8):827-42
19538167
J Organomet Chem. 2009 Dec 15;694(26):4134-4139
20177431
J Am Chem Soc. 2005 Aug 24;127(33):11622-3
16104737
ChemMedChem. 2006 May;1(5):560-4
16892392
Mini Rev Med Chem. 2004 Jan;4(1):49-60
14754443