title: Axon guidance: repulsion and attraction in roundabout ways.
abstract: The secreted signal Slit and its three receptors, Robo1-3, regulate axon guidance in the Drosophila nervous system. Differences in expression and structure of Robo paralogs contribute to diversifying growth cone responses to a common ligand.
authors.affiliation: Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Kartik S
authors.initials: KS
authors.lastname: Pappu
authors.forename: S Lawrence
authors.initials: SL
authors.lastname: Zipursky
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development*; D005796:Genes / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009420:Nervous System / Q000254:growth & development; D011971:Receptors, Immunologic / Q000502:physiology; D000097905:Roundabout Proteins
chemical_list: D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins