title: Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.
abstract: Elaboration of our previously disclosed spiropiperidine template led to the development of a series of novel CCR5 antagonists. Results of SAR exploration and preliminary lead characterization are described.
authors.affiliation: Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. david.rotstein@comcast.net
authors.forename: David M
authors.initials: DM
authors.lastname: Rotstein
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Gabriel
authors.forename: Nicole
authors.initials: N
authors.lastname: Manser
authors.forename: Lubov
authors.initials: L
authors.lastname: Filonova
authors.forename: Fernando
authors.initials: F
authors.lastname: Padilla
authors.forename: Surya
authors.initials: S
authors.lastname: Sankuratri
authors.forename: Changhua
authors.initials: C
authors.lastname: Ji
authors.forename: Andre
authors.initials: A
authors.lastname: deRosier
authors.forename: Marianna
authors.initials: M
authors.lastname: Dioszegi
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Heilek
authors.forename: Andreas
authors.initials: A
authors.lastname: Jekle
authors.forename: Paul
authors.initials: P
authors.lastname: Weller
authors.forename: Pamela
authors.initials: P
authors.lastname: Berry
mesh_terms: D000818:Animals; D065100:CCR5 Receptor Antagonists; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D065100:CCR5 Receptor Antagonists; D048289:Imidazolidines