A new highly versatile handle for chemistry on a solid support: the pipecolic linker.
The design, synthesis, and potential application of the pipecolic linker is presented. This new versatile handle can immobilize primary, secondary, and aromatic amines, as well as alcohols, phenols, and hydrazides, on a solid support. Compared with other linkers, the anchoring step is easy and efficient. The release of final products from the resin proceeds upon acidic treatment with high purities. The pipecolic linker offers the promise of being using in peptide chemistry to produce peptides modified at the N and C terminus, peptidomimetics, as well as small organic molecules.
Zajdel
Paweł
P
Institut des Biomolécules Max Mousseron IBMM, UMR CNRS 5247, 15 avenue Charles Flahault, 34000 Montpellier, France.
Nomezine
Gaël
G
Masurier
Nicolas
N
Amblard
Muriel
M
Pawłowski
Maciej
M
Martinez
Jean
J
Subra
Gilles
G
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D010875:Pipecolic Acids / Q000737:chemistry*
D000588:Amines; D006834:Hydrazines; D010455:Peptides; D010875:Pipecolic Acids