Synthesis of the structure proposed for the natural allenic antibiotic scorodonin.
The structure proposed for scorodonin, a natural allenyne with significant antibacterial and antifungal activities, was synthesized through an enantioselective route. The spectroscopic data of the synthetic allenyne are generally consistent with those reported for the natural one, but slight yet definite differences were observed in (13)C NMR.
Jian
Ya-Jun
YJ
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Wu
Yikang
Y
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011090:Polyenes / Q000138:chemical synthesis / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011090:Polyenes; C027269:scorodonin