title: Lung cancer screening: an update, discussion, and look ahead.
abstract: Over the past few years there has been a great deal of debate about the status of lung cancer screening. The debate has focused on at least three areas: the unmet need to prove a mortality reduction from the screening tests being studied, the potential for these screening tests to produce harm, and the possible cost-effectiveness of an image-based screening program. In this manuscript, I review the chest imaging cohort and controlled trials that have been added to the evidence base over the past few years. I then discuss the evidence related to the areas that are currently debated, describe the ongoing trials that will help to clarify these issues, and speculate about the future.
authors.affiliation: Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. mazzonp@ccf.org
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mazzone
mesh_terms: D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000528:radiation effects; D008175:Lung Neoplasms / Q000175:diagnosis*; D008403:Mass Screening / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D011859:Radiography; D018570:Risk Assessment
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