title: Investigation of the possibility of using ischemia-modified albumin in testicular torsion: an experimental study.
abstract: OBJECTIVE
  To investigate the serum ischemia-modified albumin levels with use of an experimental testicular torsion (TT) model.
  
  
  METHODS
  Randomized, controlled experimental study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirty mature male Wistar rats.
  
  
  METHODS
  Rats were divided into five groups: a sham operation group, 2- and 4-hour control (groups I and III, respectively), and 2- and 4-hour torsion groups (groups II and IV, respectively). Ischemia-modified albumin, tissue and blood malondialdehyde (MDA), tissue and blood myeloperoxidase (MPO) activity levels, and histopathologic damage scores then were compared.
  
  
  METHODS
  Ischemia-modified albumin, tissue and blood MDA, tissue and blood MPO activity levels, and histopathologic damage scores.
  
  
  RESULTS
  There was a significantly higher level of histopathologic damage in the 4-hour torsion group, and the serum ischemia-modified albumin levels in this group were significantly higher than those of the other groups. There was no difference between the groups in terms of blood and tissue MDA and MPO levels. There was no significant correlation between ischemia-modified albumin levels and blood and tissue MDA and MPO levels. The only significant correlation between histopathologic score and biochemical markers was that with blood and tissue MPO.
  
  
  CONCLUSIONS
  The results from this pioneering study determined a high level of ischemia-modified albumin in TT, indicating a potential value for TT diagnosis. The value of ischemia-modified albumin levels in TT should be investigated also with respect to prognosis.
authors.affiliation: Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Kutlu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: Suha
authors.initials: S
authors.lastname: Turkmen
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turedi
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Gunduz
authors.forename: Esin
authors.initials: E
authors.lastname: Yulug
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.forename: Suleyman Caner
authors.initials: SC
authors.lastname: Karahan
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D007511:Ischemia / Q000097:blood* / Q000175:diagnosis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000032:analysis / Q000378:metabolism*; D013086:Spermatic Cord Torsion / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin