[Roles of hypertension and serum leptin in obstructive sleep apnea hypopnea syndrome].
OBJECTIVE
To explore the roles of hypertension and serum leptin in obstructive sleep apnea hypopnea syndrome (OSAHS).


METHODS
Totally 60 patients with OSAHS (OSAHS group) and 40 age- and body mass index (BMI)-matched non-OSAHS individuals (non-OSAHS group) were enrolled in this study. The neck circumference (NC), waist/hip rate (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), leptin, fasting blood glucose (FBG), triglyceral (TG), cholesterol (Chol), and true insulin (TI) were measured before and after sleep . The correlations between hypertension/serum leptin level and OSAHS were analyzed.


RESULTS
The blood pressure(in the morning), especially DBP was significantly higher in OSAHS group than in non-OSAHS control group (89.75+/-2.04) mmHg vs. (81.63+/-1.91) mmHg, P<0.01. DBP in OSAHS group was positively correlated with serum leptin and apnea hypopnea index (AHI) (r=0.282, P<0.05; r=0.318, P<0.01). Logistic regression analysis showed that BMI (P=0.029), heart rate in the morning (P =0.030), and leptin (P=0.049) were independently correlated with the development of hypertension.


CONCLUSIONS
OSAHS may independently affect blood pressure, especially DBP, after waking up. BMIHR in the morning and serum leptin may be the independent correlates of hypertension.
Huang
Rong
R
Department of Respiratory Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xiao
Yi
Y
Zhong
Xu
X
Li
Ming
M
Huang
Xi-zhen
XZ
D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D020738:Leptin