title: Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7.
abstract: A new titanocenyl amide containing flavone as pendant group has been synthesized by reaction of titanocenyl carboxylic acid chloride and 7-Aminoflavone and structurally characterized by spectroscopic methods. This species and eight previously synthesized titanocenyl amide complexes have been tested in breast adenocarcinoma cancer cell line, MCF-7. The functionalization of titanocene dichloride with amides enhances the cytotoxic activity in MCF-7. Two sets of titanocenyl amides can be identified, with IC(50) <100 muM and IC(50)>100 muM. The most cytotoxic species is Cp(CpCO-NH-C(6)H(4)-(CH(2))(2)CH(3))TiCl(2) with an IC(50) of 24(2) muM, followed by Cp(CpCO-NH-C(6)H(4)-Br)TiCl(2), IC(50) of 46(4) muM and Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2), IC(50) of 49(6) muM. There is no correlation between the nature of the para substituent on the phenyl ring and the cytotoxic properties on MCF-7 cell line.
authors.affiliation: Department of Chemistry, University of Puerto Rico, P.O. Box 9019, Mayagüez, PR 00681, USA.
authors.forename: Li Ming
authors.initials: LM
authors.lastname: Gao
authors.forename: Enrique
authors.initials: E
authors.lastname: Meléndez
references.citation: Anticancer Drugs. 2007 Mar;18(3):317-21
references.pmid: 17264765
references.citation: Eur J Clin Pharmacol. 1994;47(1):1-16
references.pmid: 7988618
references.citation: Anticancer Drugs. 2007 Mar;18(3):311-5
references.pmid: 17264764
references.citation: Angew Chem Int Ed Engl. 1979 Jun;18(6):477-8
references.pmid: 111586
references.citation: J Immunol Methods. 1983 Dec 16;65(1-2):55-63
references.pmid: 6606682
references.citation: Inorg Chem. 2010 Feb 15;49(4):1292-4
references.pmid: 20055428
references.citation: Chemistry. 2008;14(14):4160-3
references.pmid: 18384037
references.citation: Toxicol In Vitro. 2008 Mar;22(2):531-4
references.pmid: 17981007
references.citation: Met Ions Biol Syst. 2004;42:353-84
references.pmid: 15206108
references.citation: J Immunol Methods. 1986 May 22;89(2):271-7
references.pmid: 3486233
references.citation: Drug Metab Dispos. 2009 Mar;37(3):629-34
references.pmid: 19074529
references.citation: Apoptosis. 2006 Jul;11(7):1205-14
references.pmid: 16699961
references.citation: Curr Med Chem. 2000 Dec;7(12):1289-303
references.pmid: 11032972
references.citation: Crit Rev Oncol Hematol. 2002 Jun;42(3):309-15
references.pmid: 12050022
references.citation: Anticancer Agents Med Chem. 2009 Oct;9(8):827-42
references.pmid: 19538167
references.citation: J Organomet Chem. 2009 Dec 15;694(26):4134-4139
references.pmid: 20177431
references.citation: J Am Chem Soc. 2005 Aug 24;127(33):11622-3
references.pmid: 16104737
references.citation: ChemMedChem. 2006 May;1(5):560-4
references.pmid: 16892392
references.citation: Mini Rev Med Chem. 2004 Jan;4(1):49-60
references.pmid: 14754443