Prevalence of insulin resistance and its relationship with cardiovascular disease risk factors among Thai adults over 35 years old.
OBJECTIVE
To estimate the prevalence of insulin resistance (HOMA-IR) and to study its relationship with selected cardiovascular disease risk factors among Thai adults.


METHODS
This cross-sectional study was comprised of 227 men and 990 women undergoing routine health check-up. The prevalence of insulin resistance was estimated using diagnostic criteria previously employed in Asian and other populations. Spearman's rank correlation coefficients were used to evaluate associations of HOMA-IR with selected cardiovascular disease risk factors. Multivariable logistic regression procedures were used to evaluate associations of hypertriglyceridemia, low HDL-Cholesterolemia, and hypertension with varying HOMA-IR values.


RESULTS
Approximately 25.1% of men (HOMA-IR>or=1.56) and 21.5% of women (HOMA-IR>or=1.64) were classified as having insulin resistance. HOMA-IR values were statistically significantly and positively associated with body mass index, body fat percentage, waist circumference, and serum triglycerides. The values were inversely correlated with HDL-Cholesterol. When compared with those whose HOMA-IR values were within the lowest quartile (<0.45), men with HOMA-IR values in the highest quartile (>or=1.58) had higher risks of hypertriglyceridemia (adjusted OR=2.83), low HDL-Cholesterolemia (adjusted OR=2.79), and hypertension (adjusted OR=2.76). Similar associations were observed among women.


CONCLUSIONS
Insulin resistance, as determined using HOMA-IR, was positively associated with selected cardiovascular disease risk factors among Thai adults.
Do
Hau D
HD
Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
Lohsoonthorn
Vitool
V
Jiamjarasrangsi
Wiroj
W
Lertmaharit
Somrat
S
Williams
Michelle A
MA
D000328:Adult; D044466:Asian People; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
Diabetes Care. 2000 Jan;23(1):57-63
10857969
Am J Clin Nutr. 1992 Jul;56(1 Suppl):247S-248S
1615892
Diabetes Metab Res Rev. 2007 May;23(4):304-10
17001619
Arch Med Res. 1997 Spring;28(1):115-9
9078598
Diabetes Obes Metab. 2002 Nov;4(6):388-93
12406036
N Engl J Med. 1996 Apr 11;334(15):952-7
8596596
Am J Physiol. 1979 Sep;237(3):E214-23
382871
Med Clin North Am. 2004 Jan;88(1):63-82
14871051
Diabetes Res Clin Pract. 2003 Mar;59(3):225-32
12590020
Diabetes Care. 1994 Feb;17(2):107-14
8137680
J Clin Lab Anal. 2007;21(2):85-90
17385686
Diabetologia. 1985 Jul;28(7):412-9
3899825
Diabetes. 1998 Oct;47(10):1643-9
9753305
Diabetes. 2003 Aug;52(8):1888-96
12882902
Am J Clin Nutr. 2003 Feb;77(2):379-84
12540397
Diabetes. 2003 Sep;52(9):2191-7
12941756
J Pediatr. 2004 Jan;144(1):47-55
14722518
N Engl J Med. 1993 Dec 30;329(27):1988-92
8247074
Diabetes Care. 2007 Aug;30(8):2007-12
17468342