title: [Optimization of Glycyrrhiza flavonoid and ferulic acid cream by reflect-line orthogonal simplex method].
abstract: OBJECTIVE
  To optimize the formula of Glycyrrhiza flavonoid and ferulic acid cream and set up its quality control parameters.
  
  
  METHODS
  Reflect-line orthogonal simplex method was used to optimize the main factors such as amount of Myrj52-glyceryl monostearate and dimethicone, based on the appearance, spreadability and stability of the cream.
  
  
  RESULTS
  9.0% Myrj52-glyceryl monostearate (3:2) and 2.5% dimethicone were chosen in prescription. The prepared cream presented a good stability after being placed 24 h at 5 degrees C, 25 degrees C and 37 degrees C respectively,and its spreadability suited with the property of semi-fluid cream.
  
  
  CONCLUSIONS
  [corrected] The formula of Glycyrrhiza flavonoid and ferulic acid cream is suitable, and its quality is stable. The reflect-line orthogonal simplex method is suitable for the formula optimization of cream.
authors.affiliation: Affiliated Provincial Hospital,Anhui Medical University, Hefei 230001, China. lslcclhl@163.com
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Xiangqing
authors.initials: X
authors.lastname: Chen
authors.forename: Liqiang
authors.initials: L
authors.lastname: Yang
authors.forename: Dan
authors.initials: D
authors.lastname: Su
authors.forename: Yan
authors.initials: Y
authors.lastname: Fang
authors.forename: Na
authors.initials: N
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
mesh_terms: D003373:Coumaric Acids / Q000737:chemistry*; D004304:Dosage Forms; D004339:Drug Compounding; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D006035:Glycyrrhiza / Q000737:chemistry*
chemical_list: D003373:Coumaric Acids; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C004999:ferulic acid