[The study on the relationship between human papillomavirus infection and pathogenesis of nasal inverted papilloma and its malignant transformation].
OBJECTIVE
To investigate the relationship between human papillomavirus (HPV) infection and pathogenesis of nasal inverted papilloma (NIP) and its malignant transformation.


METHODS
Fifty-seven cases of NIP were divided into 2 groups: benign group, squamous cell carcinoma (SCC) arising in NIP group (malignancy group). HPV-DNA types of 6, 11, 16, 18 were detected by polymerase chain reaction (PCR) in 57 cases of NIP. Thirty cases of nasal polyps were control.


RESULTS
Total positive rate of HPV in NIP was 64.9% (37/57). The positive rate of benign group was 60% (27/45), all with single and low risk HPV11 type infection. The positive rate of malignancy group were was 83.3% (10/12), and the majority were HPV16 and HPV18. Five cases had double infection (4 with HPV16 and HPV 18, 1 with HPV11 and HPV18), four had single HPV16 infection, another one had single HPV11 infection. However, HPV-DNA was not detected in any cases of nasal polyps.


CONCLUSIONS
Infection of HPV-DNA has an important effect in pathogenesis of NIP. Meanwhile, there maybe a close relationship between high risk HPV16 type and HPV18 type and malignant transformation of NIP.
Zhong
Zhenhua
Z
Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yan
Aihui
A
Jiang
Feifei
F
Wei
Hongquan
H
Jiang
Xuejun
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology* / Q000821:virology*; D018308:Papilloma, Inverted / Q000473:pathology* / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology; D055815:Young Adult