Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole.
We investigated possible influences of 3 single nucleotide polymorphisms in the d-amino acid oxidase activator (rs2391191, rs947267, rs3918342) on clinical outcomes and side effects in 86 Korean schizophrenia patients treated with aripiprazole for 8weeks, finding that individuals carrying rs2391191 A allele had significantly lower brief psychiatric rating scale scores than subjects carrying the G allele at each time point. Further research is needed to determine the role of DAOA on the response to antipsychotics.
Pae
Chi-Un
CU
Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon, Kyonggi-Do, Republic of Korea. pae@catholic.ac.kr
Chiesa
Alberto
A
Serretti
Alessandro
A
D014150:Antipsychotic Agents / Q000627:therapeutic use; D000068180:Aripiprazole; D010054:Brief Psychiatric Rating Scale; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007723:Korea; D008297:Male; D009483:Neuropsychological Tests; D010597:Pharmacogenetics; D010879:Piperazines / Q000627:therapeutic use; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D015363:Quinolones / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D013997:Time Factors; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole