The Wada memory test and prediction of outcome after anterior temporal lobectomy.
We reviewed the records of 77 Chinese-speaking adult patients to investigate the relationship between the Wada memory test and outcomes after anterior temporal lobectomy (ATL). The ipsilateral memory scores, contralateral memory scores and Wada asymmetry index (WAI) were calculated to evaluate their relationships with seizure and cognitive outcomes. The seizure outcomes did not correlate with the unilateral memory scores or the WAI. Patients who had a smaller WAI tended to have a post-operative decline in verbal intelligence quotient (VIQ) (odds ratio: 13.54, 95% confidence interval: 1.17-156.11, p=0.037). The seven patients who failed the Wada memory test after ipsilateral injection had a higher percentage of VIQ deterioration than the 70 who passed (p=0.039). However, no patient displayed global amnesia after surgery. The Wada memory test was a predictor for post-operative VIQ changes in our study. Patients who failed the Wada memory test still benefitted from the ATL and showed good seizure outcomes.
Yu
Hsiang-Yu
HY
Department of Neurology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
Shih
Yang-Hsin
YH
Su
Tung-Ping
TP
Shan
Ian-Kai
IK
Yiu
Chun-Hin
CH
Lin
Yung-Yang
YY
Kwan
Shang-Yeong
SY
Chen
Chien
C
Yen
Der-Jen
DJ
D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007361:Intelligence Tests / Q000592:standards; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests / Q000592:standards; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology*; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D055815:Young Adult