[Investigation of simplified international diagnostic criteria for autoimmune hepatitis].
The simplified international diagnostic criteria for autoimmune hepatitis (AIH), re-revised by the International AIH Group in 2008, were investigated in 114 patients with AIH from 15 centers in Japan. While applying of the criteria, we had to pay attention to anti-nuclear antibody measurement methods, and liver histology scoring. Definite and probable AIH were diagnosed in 83 and 22 patients, respectively. The criteria were found to be useful for the diagnosis of AIH in Japan. However, 9 patients who did not meet the diagnostic criteria showed normal immunoglobulin G levels or were negative for autoantibodies. As the criteria were unreliable for diagnosing such atypical cases in the present series, we speculated that we should not rely solely on these, criteria and take a more holistic approach to diagnosis in such cases.
Kaneko
Akira
A
Department of Gastroenterology, NTT West Osaka Hospital, Japan. a.kaneko@mhc.west.ntt.co.jp
Kubo
Mitsuhiko
M
Yamada
Ryoko
R
Tanimura
Tomoki
T
Yamaguchi
Daisuke
D
Yamamoto
Moritoshi
M
Tatsumi
Nobuyuki
N
Nakama
Akihiro
A
Mita
Eiji
E
Kato
Michio
M
Hijioka
Taizo
T
Oshita
Masahide
M
Ito
Toshifumi
T
Imanaka
Kazuho
K
Katayama
Kazuhiro
K
Sato
Masako
M
Yoshihara
Harumasa
H
Kiriyama
Kazuo
K
Imai
Yasuharu
Y
Kashihara
Takeshi
T
Fukui
Hiroyuki
H
Suzuki
Kunio
K
Miyoshi
Shio
S
Yamada
Akira
A
Yakushijin
Takayuki
T
Mochizuki
Kiyoshi
K
Hiramatsu
Naoki
N
Takehara
Tetsuo
T
Hayashi
Norio
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged