title: Relationship between periodontitis and diabetes - importance of a clinical study to prove the vicious cycle.
abstract: Periodontitis is regarded to have a close relationship to diabetes mellitus. In Japan, some cohort studies have indicated that there is a significant positive association of obesity plus metabolic syndrome with periodontal diseases. As such, an increasing number of studies suggest a relationship between periodontitis and diabetes, most of which are epidemiologic association. In this review, we have summarized the possible evidence of a relationship between periodontitis and diabetes. To date, little evidence has been reported to indicate that diabetes and/or glucose intolerance has in fact had a significant cause-effect relationship with periodontal disease. In this regard, it is important to directly uncover the relation, i.e., to prove the effect of therapeutic approaches to periodontitis upon mitigation of glycemic control in diabetic patients, which would be a direct evidence of its causal nature. Therefore a study should be undertaken to this effect.
authors.affiliation: Division of Periodontology and Endodontology, School of Dentistry, Health Science University of Hokkaido.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
authors.forename: Sayaka
authors.initials: S
authors.lastname: Katagiri
authors.forename: Maki
authors.initials: M
authors.lastname: Takaichi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Nawarat
authors.initials: N
authors.lastname: Wara-Aswapati
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Satoko
authors.initials: S
authors.lastname: Ohara
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tagami
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Furuichi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D002986:Clinical Trials as Topic; D048909:Diabetes Complications / Q000453:epidemiology; D006801:Humans; D007564:Japan; D024821:Metabolic Syndrome / Q000150:complications; D008954:Models, Biological; D009765:Obesity / Q000150:complications; D010518:Periodontitis / Q000150:complications* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy