title: Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain.
abstract: Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.
authors.affiliation: Smilow Neuroscience Program, Department of Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Vitor H
authors.initials: VH
authors.lastname: Sousa
authors.forename: Gord
authors.initials: G
authors.lastname: Fishell
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002454:Cell Differentiation; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013687:Telencephalon / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D000074482:Thyroid Nuclear Factor 1; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000071676:Zinc Finger Protein GLI1
chemical_list: D053823:Hedgehog Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; C465570:Shh protein, mouse; D000074482:Thyroid Nuclear Factor 1; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1; D005346:Fibroblast Growth Factors
references.citation: Nat Rev Neurosci. 2002 Dec;3(12):943-51
references.pmid: 12461551
references.citation: J Neurosci. 2010 Feb 3;30(5):1582-94
references.pmid: 20130169
references.citation: Development. 1997 Jul;124(14):2709-18
references.pmid: 9226442
references.citation: Development. 2005 Nov;132(22):4987-98
references.pmid: 16221724
references.citation: Neuron. 1995 Jun;14(6):1141-52
references.pmid: 7605629
references.citation: J Neurosci. 2007 Jul 18;27(29):7786-98
references.pmid: 17634372
references.citation: J Neurosci. 2010 Feb 24;30(8):2812-23
references.pmid: 20181579
references.citation: Curr Opin Neurobiol. 2001 Feb;11(1):43-9
references.pmid: 11179871
references.citation: Neuron. 2010 Feb 11;65(3):328-40
references.pmid: 20159447
references.citation: Neuron. 2008 Sep 11;59(5):722-32
references.pmid: 18786356
references.citation: Dev Biol. 2002 Nov 15;251(2):320-32
references.pmid: 12435361
references.citation: Development. 1995 Oct;121(10):3267-78
references.pmid: 7588061
references.citation: Dev Suppl. 1991;Suppl 2:105-22
references.pmid: 1842349
references.citation: J Neurosci. 2006 Sep 6;26(36):9282-92
references.pmid: 16957084
references.citation: Genes Dev. 2005 Mar 1;19(5):626-41
references.pmid: 15741323
references.citation: J Comp Neurol. 2008 Jan 1;506(1):16-29
references.pmid: 17990269
references.citation: Neuron. 1992 May;8(5):957-66
references.pmid: 1350202
references.citation: Dev Cell. 2004 Jan;6(1):103-15
references.pmid: 14723851
references.citation: Cell. 1991 Feb 8;64(3):635-47
references.pmid: 1991324
references.citation: J Neurosci. 2009 Dec 16;29(50):15933-46
references.pmid: 20016109
references.citation: Nat Neurosci. 2009 Feb;12(2):141-9
references.pmid: 19136974
references.citation: Development. 2002 Nov;129(21):4963-74
references.pmid: 12397105
references.citation: Development. 2001 Feb;128(4):527-40
references.pmid: 11171336
references.citation: Mol Cell Neurosci. 2008 Apr;37(4):845-56
references.pmid: 18316204
references.citation: J Neurosci. 2004 Mar 17;24(11):2612-22
references.pmid: 15028753
references.citation: Dev Biol. 1994 Apr;162(2):402-13
references.pmid: 8150204
references.citation: Neuron. 2005 Nov 23;48(4):591-604
references.pmid: 16301176
references.citation: Curr Opin Genet Dev. 2009 Aug;19(4):315-22
references.pmid: 19596567
references.citation: Development. 1998 Dec;125(24):5079-89
references.pmid: 9811591
references.citation: Oncogene. 1999 Dec 20;18(55):7852-9
references.pmid: 10630638
references.citation: J Neurosci. 2007 Sep 5;27(36):9682-95
references.pmid: 17804629
references.citation: Neuron. 2003 Sep 11;39(6):937-50
references.pmid: 12971894
references.citation: Development. 2006 May;133(9):1831-44
references.pmid: 16613831
references.citation: Development. 1999 Jan;126(2):281-92
references.pmid: 9847242
references.citation: Cereb Cortex. 2009 Jul;19 Suppl 1:i1-10
references.pmid: 19363146
references.citation: Nat Rev Neurosci. 2006 Oct;7(10):772-83
references.pmid: 16988653
references.citation: Development. 2000 Apr;127(8):1593-605
references.pmid: 10725236
references.citation: Dev Biol. 1995 Aug;170(2):299-313
references.pmid: 7649364
references.citation: Development. 2007 Nov;134(22):4083-93
references.pmid: 17965053
references.citation: Mol Cell Biol. 2006 May;26(9):3365-77
references.pmid: 16611981
references.citation: J Neurosci. 2003 Nov 19;23(33):10568-76
references.pmid: 14627641
references.citation: Neuron. 2009 Aug 27;63(4):451-65
references.pmid: 19709628
references.citation: Nat Neurosci. 2002 Dec;5(12):1279-87
references.pmid: 12411960
references.citation: Development. 2003 Aug;130(16):3891-902
references.pmid: 12835403
references.citation: Development. 2006 Aug;133(15):2937-46
references.pmid: 16818446
references.citation: Development. 1995 Dec;121(12):3923-33
references.pmid: 8575293
references.citation: Cereb Cortex. 2006 Jul;16 Suppl 1:i89-95
references.pmid: 16766713
references.citation: Dev Biol. 2008 Feb 1;314(1):127-36
references.pmid: 18155689
references.citation: Dev Biol. 2001 Aug 1;236(1):76-88
references.pmid: 11456445
references.citation: Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
references.pmid: 19386638
references.citation: Development. 2004 Oct;131(20):5031-40
references.pmid: 15371303
references.citation: Cell. 1993 Dec 31;75(7):1417-30
references.pmid: 7916661
references.citation: J Neurosci. 2000 Aug 15;20(16):6063-76
references.pmid: 10934256
references.citation: Nat Rev Genet. 2000 Oct;1(1):20-9
references.pmid: 11262869
references.citation: J Neurosci. 2003 Jan 1;23(1):167-74
references.pmid: 12514213
references.citation: Dev Biol. 2000 Mar 15;219(2):373-83
references.pmid: 10694429
references.citation: Dev Biol. 2009 Oct 1;334(1):264-75
references.pmid: 19632216
references.citation: Development. 2000 Dec;127(23):5007-20
references.pmid: 11060228
references.citation: Development. 1998 Aug;125(15):2759-70
references.pmid: 9655799
references.citation: Development. 1998 Jul;125(14):2533-43
references.pmid: 9636069
references.citation: J Neurosci. 2007 Oct 10;27(41):10935-46
references.pmid: 17928435
references.citation: Development. 2001 Jul;128(13):2545-54
references.pmid: 11493571
references.citation: Development. 2003 Oct;130(20):4895-906
references.pmid: 12930780
references.citation: Genes Dev. 2001 Dec 1;15(23):3059-87
references.pmid: 11731473
references.citation: Nat Rev Neurosci. 2008 Sep;9(9):678-85
references.pmid: 19143049
references.citation: J Anat. 1976 Feb;121(Pt 1):71-84
references.pmid: 1254534
references.citation: Development. 1999 Aug;126(15):3359-70
references.pmid: 10393115
references.citation: Development. 1993 Jan;117(1):205-18
references.pmid: 8223247
references.citation: Genes Dev. 2002 Nov 15;16(22):2865-78
references.pmid: 12435629
references.citation: Nature. 2007 Nov 29;450(7170):717-20
references.pmid: 18046410
references.citation: Cell. 1996 Nov 15;87(4):661-73
references.pmid: 8929535
references.citation: J Neurosci. 2008 Dec 10;28(50):13582-91
references.pmid: 19074032