Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts prognosis after acute coronary syndrome--a pilot study.
BACKGROUND
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It is shed, in part, by proteases and released as soluble LOX-1 (sLOX-1), which is a specific and sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS.


RESULTS
ACS patients undergoing emergency percutaneous coronary intervention and measurement of circulating sLOX-1 were followed (median: 896 days). Among 94 patients, 13 had ACS recurrence or died (re-ACS/death group). None of age, sex, lipid profile or prevalence of diabetes, smoking or hypertension was significantly different between the re-ACS/death group and the event-free survival group. Circulating sLOX-1 levels, but not those of high-sensitivity C-reactive protein (hs-CRP) or troponin T (TnT), were significantly (P<0.005) higher in the re-ACS/death group than in the event-free survival group. Kaplan-Meier survival curves showed that ACS patients with sLOX-1 values in the highest quartile or tertile had more frequent and earlier ACS recurrence or death. Receiver-operating characteristic curves for prediction of re-ACS or death showed higher sensitivity and specificity for sLOX-1 (area under the curve for sLOX-1, hs-CRP and TnT: 0.764, 0.658 and 0.524, respectively).


CONCLUSIONS
Circulating sLOX-1, a diagnostic biomarker of ACS, also predicts ACS recurrence or death.
Kume
Noriaki
N
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. nkume@kuhp.kyoto-u.ac.jp
Mitsuoka
Hirokazu
H
Hayashida
Kazutaka
K
Tanaka
Masaru
M
Kita
Toru
T
D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D006801:Humans; D053208:Kaplan-Meier Estimate; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012008:Recurrence; D051127:Scavenger Receptors, Class E / Q000097:blood*
D015415:Biomarkers; D051127:Scavenger Receptors, Class E