Sub-chronic toxicity of Senilia senilis hepatopancreas in albino Wistar mice.
This study investigates the sub-chronic effects of shellfish possibly contaminated by algal toxins in albino Wistar mice. Following in-feed treatment with hepatopancreas, there were significant (p < 0.05) differences in packed cell volume, haemoglobin concentration, red blood cell count, lymphocyte count and alanine aminotransferase between the different treatment groups and control. Post mortem revealed inflammation and congestion in the gastrointestinal tract of the middle and highest dose groups. The stomach of the mice fed on the highest dose of the hepatopancreas showed severe ulcerations, leaving behind deep cavities and necrotic tissues on the glandular epithelium of the mucosal wall.
Igboeli
Okechukwu O
OO
Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. oigboeli@upei.ca
Asuzu
Isaac U
IU
D000821:Animal Feed; D000818:Animals; D004784:Environmental Monitoring; D043143:Hepatopancreas / Q000737:chemistry*; D008387:Marine Toxins / Q000032:analysis / Q000302:isolation & purification / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009549:Nigeria; D012758:Shellfish / Q000633:toxicity*; D057096:Shellfish Poisoning / Q000209:etiology*; D018675:Toxicity Tests / Q000379:methods*
D008387:Marine Toxins