Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration.
Recent human genetic studies and postmortem brain examinations of schizophrenia patients strongly indicate that dysregulation of NRG1 and ErbB4 may be important pathogenic factors of schizophrenia. However, this hypothesis has not been validated and fully investigated in animal models of schizophrenia. In this study we quantitatively examined NRG1 and ErbB4 protein expressions by immunohistochemistry and Western blot in the brain of a rat schizophrenia model induced by chronic administration of MK-801 (a noncompetitive NMDA receptor antagonist). Our data showed that NRG1beta and ErbB4 expressions were significantly increased in the rat prefrontal cortex and hippocampus but in different subregions. These findings suggest that altered expressions of NRG1 and ErbB4 might be attributed to the schizophrenia. Further study in the role and mechanism of NRG1 and ErbB4 may lead to better understanding of the pathophysiology for this disorder.
Feng
Yu
Y
Key Laboratory of Mental Health of National Health Ministry, Institute of Mental Health, Peking University, No. 51 Hua Yuan Bei Road, Haidian District, Beijing 100191, China.
Wang
Xiao-Dong
XD
Guo
Chun-Mei
CM
Yang
Yang
Y
Li
Ji-Tao
JT
Su
Yun-Ai
YA
Si
Tian-Mei
TM
D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000009:adverse effects; D066246:ErbB Receptors / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D020890:Neuregulin-1 / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D066247:Receptor, ErbB-4; D012559:Schizophrenia / Q000139:chemically induced / Q000378:metabolism
D020890:Neuregulin-1; C117467:neuregulin beta; D016291:Dizocilpine Maleate; C587689:ERBB4 protein, human; D066246:ErbB Receptors; C587691:Erbb4 protein, rat; D066247:Receptor, ErbB-4
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