Protein secretion: unconventional exit by exophagy.
Certain secreted proteins bypass the canonical exit pathway from cells. Two studies now shed light on the unconventional secretion route taken by the yeast acyl-coenzyme A-binding protein: this protein is sequestered into autophagic vesicles that are re-routed to the plasma membrane where their content is released to the extracellular space.
Abrahamsen
Hilde
H
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0310 Oslo, Norway.
Stenmark
Harald
H
D001343:Autophagy / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology; D026261:Diazepam Binding Inhibitor / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D055571:Secretory Pathway / Q000502:physiology*; D022142:Secretory Vesicles / Q000502:physiology*
C492820:ACB1 protein, S cerevisiae; D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D029701:Saccharomyces cerevisiae Proteins