Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities.
Twelve new dibenzocyclooctadiene lignans, marlignans A-L (1-12), together with 16 known compounds, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-12 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques. Compounds 1-12 were evaluated for their anti-HIV activities, of which compounds 3, 6, 8, and 12 showed modest activities with therapeutic index values of 13.2, 15.6, 17.6, and 16.4, respectively.
Yang
Guang-Yu
GY
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Li
Yin-Ke
YK
Wang
Rui-Rui
RR
Li
Xiao-Nian
XN
Xiao
Wei-Lie
WL
Yang
Liu-Meng
LM
Pu
Jian-Xin
JX
Zheng
Yong-Tang
YT
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032141:Schisandra / Q000737:chemistry*
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans