Kidney disease associated with plasma cell dyscrasias.
Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.
Heher
Eliot C
EC
Massachusetts General Hospital, Boston, 02114, USA. eheher@partners.org
Goes
Nelson B
NB
Spitzer
Thomas R
TR
Raje
Noopur S
NS
Humphreys
Benjamin D
BD
Anderson
Kenneth C
KC
Richardson
Paul G
PG
D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications* / Q000473:pathology
Clin J Am Soc Nephrol. 2008 Nov;3(6):1684-90
18945993
Leukemia. 2008 Jul;22(7):1343-53
18509355
Blood. 2007 Mar 15;109(6):2604-6
17138816
Lab Invest. 2004 Apr;84(4):440-51
14990980
Arch Pathol Lab Med. 2004 Aug;128(8):875-9
15270616
Transplantation. 2009 Apr 15;87(7):947-52
19352111
Clin J Am Soc Nephrol. 2008 Sep;3(5):1339-49
18632851
Clin Chem. 2001 Apr;47(4):673-80
11274017
Biochemistry. 1995 Aug 29;34(34):10697-702
7662653
N Engl J Med. 2006 Mar 30;354(13):1362-9
16571879
Am J Transplant. 2006 Sep;6(9):2121-33
16796719
Leukemia. 2008 Apr;22(4):842-9
18200040
Kidney Int. 2002 Dec;62(6):1977-88
12427122
Ann Intern Med. 2005 Dec 6;143(11):777-84
16330788
Am J Physiol Renal Physiol. 2001 Apr;280(4):F562-73
11249847
Am J Kidney Dis. 2004 Jan;43(1):147-53
14712438
Kidney Int. 2006 Dec;70(12):2148-51
17063172
Blood. 2008 Mar 1;111(5):2516-20
17975015
Br J Haematol. 2009 Feb;144(3):446-7; author reply 447-8
19120361
Blood. 2008 Feb 1;111(3):1101-9
17989313
Nat Rev Cancer. 2007 Aug;7(8):585-98
17646864
J Pharmacol Exp Ther. 2008 Dec;327(3):645-56
18776064
Cancer. 2005 Mar 15;103(6):1195-200
15690325
Hematol Oncol Clin North Am. 2007 Dec;21(6):1007-34, vii-viii
17996586
N Engl J Med. 2005 Jun 16;352(24):2487-98
15958804
Blood. 2007 Aug 1;110(3):827-32
17416735
N Engl J Med. 2008 Aug 28;359(9):906-17
18753647
J Am Soc Nephrol. 2001 Jul;12(7):1558-1565
11423587
N Engl J Med. 2007 Sep 13;357(11):1083-93
17855669
Br J Haematol. 2003 Jul;122(1):78-84
12823348
Blood. 2007 Apr 15;109(8):3489-95
17209057
Cancer Res. 2001 Apr 1;61(7):3071-6
11306489
Kidney Int. 2009 Oct;76(7):792-7
19165173
Br J Haematol. 2003 Jun;121(5):749-57
12780789
Am J Kidney Dis. 1999 Feb;33(2):E5
10074605
N Engl J Med. 2004 Oct 28;351(18):1860-73
15509819
J Biochem. 1985 Jul;98(1):87-93
3900059
Trials. 2008 Sep 28;9:55
18822172
Am J Kidney Dis. 2004 Jan;43(1):E10-6
14712467
Blood. 1981 Feb;57(2):333-8
7448427
Lab Invest. 1991 Apr;64(4):527-37
1901926
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1285-90
18202175
Eur J Haematol. 2005 Jul;75(1):27-33
15946307
Br J Haematol. 2007 Sep;138(5):640-3
17686058
Haematologica. 2007 Apr;92(4):546-9
17488666
Nephrol Dial Transplant. 2008 Dec;23(12):3888-94
18596130
Am J Kidney Dis. 2005 Jan;45(1):102-11
15696449
N Engl J Med. 2009 Jun 18;360(25):2645-54
19535803
J Clin Oncol. 2005 Dec 20;23(36):9219-26
16275935
J Am Soc Nephrol. 2007 Apr;18(4):1239-45
17360948
Br J Haematol. 2003 Jul;122(1):160-1
12823359
J Pharm Pharmacol. 2003 Dec;55(12):1701-6
14738599
Clin Chem. 2007 Nov;53(11):1985-6
17954504
Am J Pathol. 1999 Dec;155(6):2009-17
10595931
Clin Chem. 2002 Sep;48(9):1437-44
12194920
Leuk Lymphoma. 2008 May;49(5):890-5
18464107
J Clin Invest. 1982 Aug;70(2):453-60
6808027
J Clin Oncol. 2007 May 20;25(15):1993-9
17420512
Br J Haematol. 1995 Dec;91(4):854-9
8547129
Am J Nephrol. 2001 May-Jun;21(3):237-40
11423695
N Engl J Med. 2007 Mar 15;356(11):1110-20
17360989
Kidney Int. 2007 Oct;72(8):1035-6
17914422
Cancer Res. 2007 Feb 15;67(4):1783-92
17308121
J Am Soc Nephrol. 2009 Sep;20(9):2055-64
19470674
Oncologist. 2007 Jun;12(6):664-89
17602058
Clin Ther. 2006 Jun;28(6):953-9
16860177
Haematologica. 2007 Oct;92(10):1411-4
17768111
Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5446-50
8202506
Am J Kidney Dis. 2003 Dec;42(6):1154-63
14655186
Eur J Haematol. 2000 Sep;65(3):175-81
11007053
Blood. 2006 Oct 15;108(8):2520-30
16794250
Am J Kidney Dis. 2000 Sep;36(3):E19
10977812
Br J Haematol. 2008 Mar;140(6):625-34
18302711
Eur J Haematol. 1994 Oct;53(4):207-12
7957804
Br J Haematol. 2008 Oct;143(1):143-5; author reply 145-6
18671704
Kidney Int. 2003 Jul;64(1):281-9
12787420
Blood. 2006 Jul 15;108(2):536-43
16543471
Am J Physiol Renal Physiol. 2003 Jun;284(6):F1245-54
12582006
Blood. 2004 Jan 1;103(1):20-32
12969978
Arch Pathol Lab Med. 2006 Feb;130(2):165-9
16454555
Am J Nephrol. 1994;14(3):187-91
7977478
Hematol Oncol Clin North Am. 1999 Dec;13(6):1273-80
10626150
Am J Transplant. 2009 Jan;9(1):201-9
18976291
Blood. 2009 Mar 26;113(13):3040-9
19164601
Lancet. 1999 Jul 10;354(9173):93-9
10408483
Kidney Int. 2008 Jun;73(11):1282-8
18385667
Am J Transplant. 2005 Jul;5(7):1660-70
15943624
Curr Opin Drug Discov Devel. 2008 Jan;11(1):60-71
18175268
Bone Marrow Transplant. 2007 Dec;40(12):1097-100
17906702
Transfusion. 2007 Mar;47(3):511-4
17319833