[Genetic features of Helicobacter pylori at patients with duodenal ulcer].
This article presents the results of original research, which showed that in St. Petersburg in patients with duodenal ulcer and chronic gastroduodenitis were identified more pathogenic strains of H. pylori, than in healthy voluntary infants infected with this microorganism. The most frequently detected genes, islands of H. pylori pathogenicity, in chronic gastroduodenitis--cagA and cagH, with peptic ulcer--cagA and cagE. Also found that in St. Petersburg in a greater percentage of cases circulating cagA + strains of H. pylori, as in Tajikistan. Based on these data, we can conclude that improved methods of molecular-genetic identification of H. pylori is a required condition for the optimization approaches to integrated diagnostics H. pylori-associated.
Baryshnikova
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D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000235:genetics* / Q000382:microbiology; D005260:Female; D044404:Genomic Islands / Q000235:genetics*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000235:genetics*; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D008297:Male
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori