title: Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.
abstract: Although childhood acute lymphoblastic leukemia is the most common pediatric cancer, its etiology remains poorly understood. In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia. We also confirmed a selective effect for B-cell acute lymphoblastic leukemia with hyperdiploidy and report a putative gender-specific effect of ARID5B SNPs on acute lymphoblastic leukemia risk in males. This study provides a strong rationale for more detailed analysis to identify the causal variants at this locus and to better understand the overall functional contribution of ARID5B to childhood acute lymphoblastic leukemia susceptibility.
authors.affiliation: Division of Hematology-Oncology, Sainte-Justine Hospital Research Center, 3175 chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Healy
authors.forename: Chantal
authors.initials: C
authors.lastname: Richer
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bourgey
authors.forename: Ekaterini A
authors.initials: EA
authors.lastname: Kritikou
authors.forename: Daniel
authors.initials: D
authors.lastname: Sinnett
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: C503805:ARID5B protein, human; D004268:DNA-Binding Proteins; D014157:Transcription Factors
references.citation: Nat Genet. 2009 Sep;41(9):1001-5
references.pmid: 19684603
references.citation: Genetics. 2005 Nov;171(3):1321-30
references.pmid: 15944347
references.citation: Blood. 2007 Jan 15;109(2):683-92
references.pmid: 17008550
references.citation: Cell Growth Differ. 2002 Mar;13(3):95-106
references.pmid: 11959810
references.citation: Leuk Res. 2009 Jun;33(6):759-63
references.pmid: 19101034
references.citation: Leukemia. 2010 Apr;24(4):894-6
references.pmid: 20054350
references.citation: Int J Cancer. 2002 Jan 10;97(2):230-6
references.pmid: 11774269
references.citation: Leuk Res. 1997 Sep;21(9):817-23
references.pmid: 9393596
references.citation: Leuk Lymphoma. 2007 Apr;48(4):786-92
references.pmid: 17454638
references.citation: Nucleic Acids Res. 1996 May 1;24(9):1695-701
references.pmid: 8649988
references.citation: Genet Epidemiol. 2004 Jul;27(1):21-32
references.pmid: 15185400
references.citation: Eur J Cancer. 1999 Dec;35(14):1941-53
references.pmid: 10711237
references.citation: Blood. 1999 Mar 1;93(5):1496-501
references.pmid: 10029576
references.citation: Blood. 2008 Jun 15;111(12):5515-23
references.pmid: 18334672
references.citation: Am J Hum Genet. 1998 Jul;63(1):259-66
references.pmid: 9634505
references.citation: Genet Epidemiol. 2002 Nov;23(4):426-43
references.pmid: 12432508
references.citation: Nat Genet. 2009 Sep;41(9):1006-10
references.pmid: 19684604
references.citation: Biol Proced Online. 2007 Nov 01;9:27-42
references.pmid: 18213362
references.citation: Pediatr Clin North Am. 2008 Feb;55(1):1-20, ix
references.pmid: 18242313
references.citation: Blood. 2010 Mar 4;115(9):1765-7
references.pmid: 20042726