No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition.
A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry-informative principal components as covariates, the effect of 5-HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868-1.172, P = 0.91). In cases only, 5-HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons.
Konneker
Thomas I
TI
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7264, USA.
Crowley
James J
JJ
Quackenbush
Corey R
CR
Keefe
Richard S E
RS
Perkins
Diana O
DO
Stroup
T Scott
TS
Lieberman
Jeffrey A
JA
van den Oord
Edwin
E
Sullivan
Patrick F
PF
D000293:Adolescent; D000328:Adult; D000368:Aged; D003071:Cognition; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
Am J Hum Genet. 2006 May;78(5):815-826
16642437
JAMA. 2009 Jun 17;301(23):2462-71
19531786
Mol Psychiatry. 2008 Jun;13(6):570-84
18347602
Schizophr Bull. 2003;29(1):15-31
12908658
Arch Gen Psychiatry. 2006 Oct;63(10):1069-72
17015808
Neuropsychopharmacology. 2006 Sep;31(9):2033-46
16641947
Biol Psychiatry. 2007 Apr 1;61(7):902-10
17161382
Science. 1996 Nov 29;274(5292):1527-31
8929413
Cytogenet Cell Genet. 1997;79(3-4):214-20
9605856