title: Catechol derivatives inhibit the fibril formation of amyloid-beta peptides.
abstract: The inhibition of fibril formation of amyloid beta proteins (A beta) would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). Dopamine (DA) and other catechol derivatives were used as inhibitory factors for A beta fibril formation. The fibril formation of A beta was monitored by Thioflavin T fluorescence, a transmission electron microscopy (TEM) and a total internal reflection fluorescence microscopy (TIRFM). Catechol and its derivatives showed the dose-dependent inhibitory effects on the spontaneous A beta fibril formation. The inhibitory activity depended on the chemical structure of catechol derivatives both in the presence and absence of the liposome a model of biomembrane. Formation of catechol quinone-conjugated-A beta adduct by a Schiff-base is a key step for the inhibition effect of A beta fibril formation.
authors.affiliation: Division of Chemical Engineering, Department of Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Vu Thi
authors.initials: VT
authors.lastname: Huong
authors.forename: Toshinori
authors.initials: T
authors.lastname: Shimanouchi
authors.forename: Naoya
authors.initials: N
authors.lastname: Shimauchi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Umakoshi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Goto
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kuboi
mesh_terms: D000682:Amyloid / Q000187:drug effects* / Q000648:ultrastructure; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D052160:Benzothiazoles; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology*; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D010446:Peptide Fragments / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D002396:Catechols; D010446:Peptide Fragments; D013844:Thiazoles; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); C009462:thioflavin T