The Alzheimer's disease neuroimaging initiative: progress report and future plans.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6-year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer's disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid (CSF)/blood biomarkers as predictors and outcomes for use in clinical trials of AD treatments. Structural MRI, FDG PET, C-11 Pittsburgh compound B (PIB) PET, CSF measurements of amyloid beta (Abeta) and species of tau, with clinical/cognitive measurements were performed on elderly controls, subjects with mild cognitive impairment, and subjects with AD. Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects. FDG PET, C-11 Pittsburgh compound B PET, and CSF measurements of Abeta and tau were significant predictors of cognitive decline and brain atrophy. All data are available at UCLA/LONI/ADNI, without embargo. ADNI-like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD.
Weiner
Michael W
MW
Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA, USA. michael.weiner@ucsf.edu
Aisen
Paul S
PS
Jack
Clifford R
CR
Jagust
William J
WJ
Trojanowski
John Q
JQ
Shaw
Leslie
L
Saykin
Andrew J
AJ
Morris
John C
JC
Cairns
Nigel
N
Beckett
Laurel A
LA
Toga
Arthur
A
Green
Robert
R
Walter
Sarah
S
Soares
Holly
H
Snyder
Peter
P
Siemers
Eric
E
Potter
William
W
Cole
Patricia E
PE
Schmidt
Mark
M
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000453:epidemiology; D000569:Americas / Q000453:epidemiology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001931:Brain Mapping; D003952:Diagnostic Imaging / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends*; D018450:Disease Progression; D049674:History, 21st Century; D006801:Humans; D007391:International Cooperation; D008137:Longitudinal Studies; D008954:Models, Biological; D015337:Multicenter Studies as Topic; D016730:Program Development; D011877:Radionuclide Imaging
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