Increased urinary excretion of carnitine and acylcarnitine by mercuric chloride is reversed by 2,3-dimercapto-1-propanesulfonic acid in rats.
This investigation was aimed to study the effect of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on mercuric chloride (HgCl(2))-induced alterations in urinary excretion of various carnitine fractions including free carnitine (FC), acylcarnitine (AC), and total carnitine (TC). Different groups of Wistar male rats were treated with HgCl(2) at the doses of 0.1, 0.5, 1.0, 2.0, and 3.0 mg/kg body weight, and the animals were sacrificed at 24 hours following HgCl(2) injection. A separate batch of animals received HgCl(2) (2 mg/kg) with or without DMPS (100 mg/kg) and sacrificed at 24 or 48 hours after dosing. Administration of HgCl(2) resulted in statistically significant and dose-dependent increase in the urinary excretion of FC, AC, and TC in rats. However, the ratio of urinary AC:FC was significantly decreased by HgCl(2). Pretreatment with DMPS offered statistically significant protection against HgCl(2)-induced alterations in various urinary carnitine fractions in rats.
Al-Madani
Waleed A
WA
College of Science, King Saud University, Riyadh, Saudi Arabia. khan_haseeb@yahoo.com
Siddiqi
Nikhat J
NJ
Alhomida
Abdullah S
AS
Khan
Haseeb A
HA
Arif
Ibrahim A
IA
Kishore
Uday
U
D000465:Algorithms; D000818:Animals; D000931:Antidotes / Q000494:pharmacology* / Q000627:therapeutic use; D015415:Biomarkers / Q000652:urine; D002331:Carnitine / Q000031:analogs & derivatives* / Q000652:urine*; D002614:Chelating Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015913:Chelation Therapy; D004305:Dose-Response Relationship, Drug; D015386:Hazardous Substances / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000652:urine; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014494:Unithiol / Q000494:pharmacology* / Q000627:therapeutic use
D000931:Antidotes; D015415:Biomarkers; D002614:Chelating Agents; D015386:Hazardous Substances; C116917:acylcarnitine; D014494:Unithiol; D008627:Mercuric Chloride; D002331:Carnitine