[Research on conventional and molecular epidemiology of tuberculosis in Orizaba, Veracruz, 1995-2008].
This study describes the achievements of the Mexican Consortium against Tuberculosis, in the Sanitary District of Orizaba, Veracruz, Mexico between 1995 and 2008. In brief, the main results can be classified as follows: 1) Conventional and molecular epidemiology (measurement of burden of disease, trends, risk factors and vulnerable groups, consequences of drug resistance, identification of factors that favor nosocomial and community transmission); 2) Development of diagnostic techniques to detect drug resistance, description of circulating clones and adaptation of simple techniques to be used in the field; 3) Evaluation of usefulness of tuberculin skin test, immunologic responses to BCG, impact of directly observed therapy for tuberculosis (DOTS), and study of immunological biomarkers and 4) Comments on ethical aspects of tuberculosis research. Additionally, we describe the impact on public policies, transference of technology, capacity building and future perspectives.
Jiménez-Corona
Ma Eugenia
ME
Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
García-García
Lourdes
L
León
Alfredo Ponce de
AP
Bobadilla-del Valle
Miriam
M
Torres
Martha
M
Canizales-Quintero
Sergio
S
Palacios-Merino
Carmen
C
Molina-Hernández
Susana
S
Martínez-Gamboa
Rosa Areli
RA
Juárez-Sandino
Luis
L
Cano-Arellano
Bulmaro
B
Ferreyra-Reyes
Leticia
L
Cruz-Hervert
Luis Pablo
LP
Báez-Saldaña
Renata
R
Ferreira-Guerrero
Elizabeth
E
Sada
Eduardo
E
Marquina
Brenda
B
Sifuentes-Osornio
José
J
D006801:Humans; D008800:Mexico / Q000453:epidemiology; D017720:Molecular Epidemiology; D013997:Time Factors; D014376:Tuberculosis / Q000453:epidemiology*