Relationships between telocytes and cardiomyocytes during pre- and post-natal life.
Evidence has been given that the adult heart contains a specific population of stromal cells lying in close spatial relationship with cardiomyocytes and with cardiac stem cells in sub-epicardial cardiogenic niches. Recently termed 'telocytes' because of their long cytoplasmic processes embracing the parenchymal cells, these cells have been postulated to be involved in heart morphogenesis. In our opinion, investigating the occurrence and morphology of telocytes during heart histogenesis may shed further light on this issue. Our findings show that typical telocytes are present in the mouse heart by early embryonic to adult life. These cells closely embrace the growing cardiomyocytes with their long, slender cytoplasmic processes. Hence, in the developing myocardium, telocytes may play nursing and guiding roles for myocardial precursors to form the correct three-dimensional tissue architectural pattern, as previously suggested.
Faussone-Pellegrini
Maria-Simonetta
MS
Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy.
Bani
D
D
D000818:Animals; D000831:Animals, Newborn; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D051379:Mice; D009206:Myocardium / Q000166:cytology* / Q000648:ultrastructure; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure
J Cell Mol Med. 2010 Apr;14(4):729-40
20367664
Exp Cell Res. 1999 Dec 15;253(2):296-301
10585250
J Cell Mol Med. 2009 Feb;13(2):295-308
19183408
Histol Histopathol. 2010 Mar;25(3):397-404
20054810
Cell. 2003 Sep 19;114(6):763-76
14505575
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14068-73
17709737
Perspect Biol Med. 2004 Summer;47(3):339-56
15247501
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S8-13
16501638
J Cell Mol Med. 2009 May;13(5):866-86
19382895
J Cell Mol Med. 2005 Oct-Dec;9(4):972-5
16364205
Trends Biotechnol. 2007 Oct;25(10):441-7
17826855