Neonatal status epilepticus due to lamination disorder without significant cell death.
BACKGROUND
Malformations of the cerebral cortex may be associated with severe epilepsy and status epilepticus. It has been shown that status epilepticus models induce excitotoxic cell death. In humans, very few data are available.


RESULTS
We report a case of a multifocal disorder of the lamination diagnosed in a neonate, born at 30 weeks' gestation, who died from a refractory status epilepticus at two months and half. This abnormality was not detected by repeated MRI studies. Only microscopic investigations permitted to identify this disorder of the lamination. We found also little cell death or cell loss.


CONCLUSIONS
Our report highlights the possible false negative results of MRI in a newborn. We can also discuss that immature human brain maybe less sensitive to neuronal injury than mature as described in animal models.
Ansart-Franquet
Hélène
H
Department of Neuropathology, University Hospital, Lille, France.
Devisme
Louise
L
Maurage
Claude-Alain
CA
Lamblin
Marie-Dominique
MD
Soto-Ares
Gustavo
G
Renard-Edun
Marie-Eve
ME
Kacet
Nadine
N
Gressens
Pierre
P
Auvin
Stéphane
S
D000818:Animals; D001921:Brain / Q000002:abnormalities*; D016923:Cell Death; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D013226:Status Epilepticus / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology*