title: Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome".
abstract: Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete. The inclusion of patients from a "CFS outbreak" previously linked with a viral infection, without confirmation in sporadic CFS cases, casts doubt on the role of XMRV in the pathogenesis of CFS.
authors.affiliation: Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. j.vandermeer@aig.umcn.nl
authors.forename: Jos W M
authors.initials: JW
authors.lastname: van der Meer
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Jochem M D
authors.initials: JM
authors.lastname: Galama
authors.forename: Frank J M
authors.initials: FJ
authors.lastname: van Kuppeveld
mesh_terms: D001773:Blood Cells / Q000821:virology*; D015331:Cohort Studies; D016207:Cytokines / Q000032:analysis; D004196:Disease Outbreaks; D015340:Epidemiologic Research Design; D015673:Fatigue Syndrome, Chronic / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D017988:Gammaretrovirus / Q000302:isolation & purification*; D006801:Humans; D012192:Retroviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*
chemical_list: D016207:Cytokines