title: [Chemotherapy and women fertility preservation].
abstract: Agressive chemotherapy can lead to premature ovarian failure and loss of fertility in women and children. Embryo cryopreservation is an established clinical procedure of fertility preservation but with several limitations. Others options are available. Cryopreservation ovarian cortex tissu have to be suggested in case of high gonadotoxic treatment. It doesn't require puberty and delay in initiation of chemotherapy. The first birth in France after orthotopic graft of ovarian tissu thawed have been recently described with a promising process. Oocyte cryopreservation is available for women without partner but the experience is limited. Gonadotrophin-releasing hormone (GnRH) agonist therapy as ovarian protectants seem interesting. Follicular growth and maturation in vitro are still experimental.
authors.affiliation: CHU Dupuytren, hôpital Mère-Enfant, service gynécologie-obstétrique, avenue Dominique-Larrey, 87000 Limoges, France. gauthiertristan@yahoo.fr
authors.forename: Tristan
authors.initials: T
authors.lastname: Gauthier
authors.forename: Pascal
authors.initials: P
authors.lastname: Piver
authors.forename: Lise-Marie
authors.initials: LM
authors.lastname: Durand
authors.forename: Lorène
authors.initials: L
authors.lastname: Donadel
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Pech
authors.forename: Christophe
authors.initials: C
authors.lastname: Roux
authors.forename: Yves
authors.initials: Y
authors.lastname: Aubard
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents