title: Role of D-dimer testing in severe pelvic inflammatory disease: a new usable marker to assess the need for fertility-impairing surgery?
abstract: Pelvic inflammatory disease (PID), like many other inflammatory diseases, can be characterized by an inflammation-induced activation of the coagulation cascade, resulting in the production of D-dimers. In this study it is demonstrated how high levels of D-dimers, assayed at the time of hospitalization, are encountered in patients diagnosed with PID and how the levels of this parameter are significantly higher in patients, which due to the severity of the disease, needed surgical treatment. Therefore the d-dimer is shown to be an important parameter to be considered in the therapeutic counseling of severe forms of PID.
authors.affiliation: Department of Maternal and Child Health, OB/GYN Unit, University of Parma, Parma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Franchi
authors.forename: Tito Silvio
authors.initials: TS
authors.lastname: Patrelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Berretta
authors.forename: Martino
authors.initials: M
authors.lastname: Rolla
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gizzo
authors.forename: Dandolo
authors.initials: D
authors.lastname: Gramellini
authors.forename: Alberto
authors.initials: A
authors.lastname: Bacchi Modena
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Nardelli
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D005260:Female; D005298:Fertility / Q000502:physiology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis* / Q000502:physiology; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D008403:Mass Screening / Q000379:methods; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D