Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry.
The relationship of magnetic field strength and Fourier transform ion cyclotron resonance mass spectrometry performance was tested using three instruments with the same design but different fields of 4.7, 7, and 9.4 tesla. We found that the theoretically predicted "transformative" effects of magnetic field are indeed observed experimentally. The most striking effects were that mass accuracy demonstrated approximately second to third order improvement with the magnetic field, depending upon the charge state of the analyte, and that peak splitting, which prohibited automated data analysis at 4.7 T, was not observed at 9.4 T.
Karabacak
N Murat
NM
Department of Chemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA.
Easterling
Michael L
ML
Agar
Nathalie Y R
NY
Agar
Jeffrey N
JN
D002247:Carbon Isotopes / Q000737:chemistry; D003198:Computer Simulation; D004574:Electromagnetic Fields; D005583:Fourier Analysis; D013058:Mass Spectrometry / Q000379:methods*; D008970:Molecular Weight; D009587:Nitrogen Isotopes / Q000737:chemistry; D013373:Substance P / Q000737:chemistry
D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D013373:Substance P
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