title: Isothiourea-mediated stereoselective C-acylation of silyl ketene acetals.
abstract: Isothiourea DHPB promotes the diastereoselective C-acylation of silyl ketene acetals with anhydrides or benzoyl fluoride, giving 3-acyl-3-aryl or 3-acyl-3-alkylfuranones in excellent yields and stereoselectivities (up to 99:1 dr).
authors.affiliation: EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, UK.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Woods
authors.forename: Louis C
authors.initials: LC
authors.lastname: Morrill
authors.forename: Tomas
authors.initials: T
authors.lastname: Lebl
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Bragg
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Smith
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000215:Acylation; D000812:Anhydrides / Q000737:chemistry; D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000080:Acetals; D000812:Anhydrides; D005030:Ethylenes; D005663:Furans; D007659:Ketones; D012821:Silanes; D013890:Thiourea; C008223:ketene