title: [Fetomaternal pharmacology : anesthesiological approach in surgical interventions during pregnancy].
abstract: The choice of anesthesia procedure for surgical interventions in pregnancy is particularly important considering the responsibility for the unborn child and the patient. Uncertainties with the treatment of this patient group and lacking routine are common. Nevertheless, 0.5-2% of pregnant women require non-gynecological surgery. In this respect knowledge about the interrelationship between physiological changes and pharmacological effects with potentially negative impact for the embryo, fetus or neonate is of particular importance. In this article the physiology relevant for anesthesia during pregnancy is discussed and commonly used drugs are reviewed to enable anesthesiologists to formulate concepts to preclude adverse effects for the mother and child and to provide an adequate therapy.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Carl Gustav Carus, Fetscherstr. 74, 01307 Dresden, Deutschland. Matthias.v.Neindorff@uniklinikum-dresden.de
authors.forename: M
authors.initials: M
authors.lastname: v Neindorff
mesh_terms: D000328:Adult; D000758:Anesthesia; D000777:Anesthetics / Q000493:pharmacokinetics; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics; D000779:Anesthetics, Local / Q000493:pharmacokinetics; D005260:Female; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009125:Muscle Relaxants, Central / Q000493:pharmacokinetics; D009294:Narcotics / Q000493:pharmacokinetics; D011247:Pregnancy; D011248:Pregnancy Complications; D012308:Risk Management; D013514:Surgical Procedures, Operative
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D009125:Muscle Relaxants, Central; D009294:Narcotics
references.citation: Anaesthesist. 1998 Jun;47(6):525-36
references.pmid: 9676315
references.citation: Anesthesiology. 1974 Apr;40(4):340-7
references.pmid: 4594570
references.citation: Pediatr Clin North Am. 1997 Feb;44(1):79-92
references.pmid: 9057785
references.citation: Clin Obstet Gynecol. 2002 Jun;45(2):553-61
references.pmid: 12048412
references.citation: Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Jan;36(1):60-2
references.pmid: 11227315
references.citation: Birth Defects Res A Clin Mol Teratol. 2003 Feb;67(2):133-40
references.pmid: 12769509
references.citation: Br Med J (Clin Res Ed). 1982 Nov 20;285(6353):1453-4
references.pmid: 6814598
references.citation: Clin Obstet Gynecol. 2003 Sep;46(3):679-87
references.pmid: 12972749
references.citation: Anesthesiology. 1999 Oct;91(4):1159-63
references.pmid: 10519516
references.citation: J Clin Pharm Ther. 1998 Feb;23(1):19-23
references.pmid: 9756107
references.citation: Surg Gynecol Obstet. 1993 Oct;177(4):371-6
references.pmid: 8211581
references.citation: Anesthesiology. 1995 Aug;83(2):300-8
references.pmid: 7631952
references.citation: Am J Surg. 2005 Sep;190(3):467-73
references.pmid: 16105538
references.citation: Anaesthesist. 2003 Oct;52(10):934-46
references.pmid: 14618250
references.citation: Chirurg. 2005 Aug;76(8):744-52
references.pmid: 16052315