title: [Wegener granulomatosis and aneurysmal subarachnoid hemorrhage: an insignificant association?].
abstract: BACKGROUND
  Wegener granulomatosis (WG) is an uncommon systemic necrotizing vasculitis that demonstrates renal and respiratory tropism. While the pathogenesis of WG remains controversial, autoimmune and inflammatory mechanisms are likely to be involved. The nervous system could be affected in up to 54% of cases. Although central nervous system involvement has been reported in 7-11% of cases, aneurysmal subarachnoid hemorrhage (SAH) occurrence is exceptional.
  
  
  METHODS
  We describe the third reported case of WG-related aneurysmal SAH and then discuss the diagnosis and pathogenesis of WG along with the physiopathology of intracranial aneurysm in light of recent data reported in the literature.
  
  
  RESULTS
  A 63-year-old woman with WG was referred to our neurosurgical department for aneurysmal SAH. The vasculitis diagnosis had been established 4 years earlier when she presented with chronic sinusitis, recurrent cystitis, and renal failure. The cerebral angiography revealed an anterior communicating artery dysplastic aneurysm. The neurosurgical management of the aneurysm was scheduled but delayed because the patient was experiencing a vasculitis flare-up. Immunosuppressive therapy and intravenous corticotherapy were given, with the patient's improvement, allowing neurosurgical clipping of the aneurysm.
  
  
  CONCLUSIONS
  Wegener granulomatosis-related aneurysmal SAH is an exceptional condition in neurovascular pathology. As inflammatory mechanisms are involved in the pathogenesis of aneurysm, the vasculitis flare-up could account for this SAH. The management of WG could benefit from anti-inflammatory therapy, as could the vasculitis-related SAH. SAH occurrence in patients with systemic vasculitis could indicate a vasculitis flare-up.
authors.affiliation: Service de neurochirurgie B, hôpital Pierre-Wertheimer, 59, boulevard Pinel, 69003 Lyon, France. dominique.marnet@laposte.net
authors.forename: D
authors.initials: D
authors.lastname: Marnet
authors.forename: C
authors.initials: C
authors.lastname: Ginguené
authors.forename: A
authors.initials: A
authors.lastname: Marcos
authors.forename: R
authors.initials: R
authors.lastname: Cahen
authors.forename: B
authors.initials: B
authors.lastname: Mac Gregor
authors.forename: F
authors.initials: F
authors.lastname: Turjman
authors.forename: B
authors.initials: B
authors.lastname: Vallée
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002533:Cerebral Angiography; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018810:Magnetic Resonance Angiography; D008875:Middle Aged; D010530:Peritoneal Dialysis; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000209:etiology
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents