title: Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury?
abstract: Systemic administration of activated protein C (APC) has been shown to reduce pulmonary inflammation in preclinical models of acute lung injury. However, there is only limited information concerning the effects of inhaled APC in modulating the severity of pulmonary inflammation. In a study reported in this issue of Critical Care, Maniatis and colleagues show that pretreatment of mice with inhaled APC is protective against ventilator-induced lung injury. While the mechanisms responsible for this effect require additional elucidation, inhaled APC appears to be a potentially useful intervention in diminishing the severity of ventilator-induced lung injury and other forms of acute lung injury.
authors.affiliation: Department of Medicine, University of Alabama at Birmingham School of Medicine, 420 Boshell Building, Birmingham, AL 35294, USA. eabraham@uab.edu
authors.forename: Edward
authors.initials: E
authors.lastname: Abraham
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D016638:Critical Illness; D051379:Mice; D011486:Protein C / Q000008:administration & dosage* / Q000494:pharmacology; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control*
chemical_list: D011486:Protein C
references.citation: Blood. 2004 Dec 15;104(13):3878-85
references.pmid: 15339848
references.citation: N Engl J Med. 2000 May 4;342(18):1301-8
references.pmid: 10793162
references.citation: Crit Care. 2010;14(2):R70
references.pmid: 20403177
references.citation: N Engl J Med. 2004 Jul 22;351(4):327-36
references.pmid: 15269312
references.citation: Blood. 2007 Apr 15;109(8):3161-72
references.pmid: 17110453
references.citation: Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2867-72
references.pmid: 17299037
references.citation: Crit Care. 2009;13(2):R51
references.pmid: 19356243
references.citation: Blood. 2004 Sep 15;104(6):1740-4
references.pmid: 15178575
references.citation: J Exp Med. 2007 Oct 1;204(10):2439-48
references.pmid: 17893198
references.citation: Crit Care Med. 2007 Jul;35(7):1660-6; quiz 1667
references.pmid: 17507824
references.citation: Vascul Pharmacol. 2006 Aug;45(2):134-40
references.pmid: 16959545
references.citation: Am J Respir Crit Care Med. 2005 Oct 1;172(7):798-806
references.pmid: 16020801
references.citation: Br J Pharmacol. 2006 Nov;149(6):740-6
references.pmid: 17016502
references.citation: Nat Med. 2009 Nov;15(11):1318-21
references.pmid: 19855397