title: The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment.
abstract: For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic 'fashions', and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients (www.IGSLI.org) and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health,lithium researchers from around the world have formed the Consortium on Lithium Genetics (www.ConLiGen.org) to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts.
authors.affiliation: Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-3719,USA. schulzet@mail.nih.gov
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
authors.forename: Martin
authors.initials: M
authors.lastname: Alda
authors.forename: Mazda
authors.initials: M
authors.lastname: Adli
authors.forename: Nirmala
authors.initials: N
authors.lastname: Akula
authors.forename: Raffaella
authors.initials: R
authors.lastname: Ardau
authors.forename: Elise T
authors.initials: ET
authors.lastname: Bui
authors.forename: Caterina
authors.initials: C
authors.lastname: Chillotti
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Piotr
authors.initials: P
authors.lastname: Czerski
authors.forename: Maria
authors.initials: M
authors.lastname: Del Zompo
authors.forename: Sevilla D
authors.initials: SD
authors.lastname: Detera-Wadleigh
authors.forename: Paul
authors.initials: P
authors.lastname: Grof
authors.forename: Oliver
authors.initials: O
authors.lastname: Gruber
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
authors.forename: Rebecca
authors.initials: R
authors.lastname: Hoban
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Layla
authors.initials: L
authors.lastname: Kassem
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Sarah
authors.initials: S
authors.lastname: Kittel-Schneider
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kliwicki
authors.forename: John R
authors.initials: JR
authors.lastname: Kelsoe
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kusumi
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Laje
authors.forename: Susan G
authors.initials: SG
authors.lastname: Leckband
authors.forename: Mirko
authors.initials: M
authors.lastname: Manchia
authors.forename: Glenda
authors.initials: G
authors.lastname: Macqueen
authors.forename: Takuya
authors.initials: T
authors.lastname: Masui
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Roy H
authors.initials: RH
authors.lastname: Perlis
authors.forename: Andrea
authors.initials: A
authors.lastname: Pfennig
authors.forename: Paola
authors.initials: P
authors.lastname: Piccardi
authors.forename: Sara
authors.initials: S
authors.lastname: Richardson
authors.forename: Guy
authors.initials: G
authors.lastname: Rouleau
authors.forename: Andreas
authors.initials: A
authors.lastname: Reif
authors.forename: Janusz K
authors.initials: JK
authors.lastname: Rybakowski
authors.forename: Johanna
authors.initials: J
authors.lastname: Sasse
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Giovanni
authors.initials: G
authors.lastname: Severino
authors.forename: Jordan W
authors.initials: JW
authors.lastname: Smoller
authors.forename: Alessio
authors.initials: A
authors.lastname: Squassina
authors.forename: Gustavo
authors.initials: G
authors.lastname: Turecki
authors.forename: L Trevor
authors.initials: LT
authors.lastname: Young
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Michael
authors.initials: M
authors.lastname: Bauer
authors.forename: Francis J
authors.initials: FJ
authors.lastname: McMahon
mesh_terms: D018692:Antimanic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D007391:International Cooperation; D018020:Lithium Compounds / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D009315:National Institute of Mental Health (U.S.); D010597:Pharmacogenetics; D010641:Phenotype; D014481:United States
chemical_list: D018692:Antimanic Agents; D018020:Lithium Compounds
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