[Male infertility and gene defects].
About 15% of the couples at reproductive age worldwide suffer from infertility. It is estimated that 50% of the entity result from male itself. The mechanism of male infertility is quite complicated, attributing to inherent and environment factors of the infertility patients, of which defects of fertility-related genes are of importance for its occurrence. The clinical features of male infertility vary from azoospermia to oligoasthenoteratozoospermia. This paper presents the relationship between the known defects in genes and male infertility.
Ruan
Jian
J
Key Lab of Gene Resource Utilization for Severe Hereditary Diseases of Ministry Education & Key Lab of Genome Research of Anhui Province, Anhui Medical University, Hefei 230032, China. software.888@163.com
Du
Wei-Dong
WD
D053713:Azoospermia / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D041322:Chromosomes, Human, Y / Q000235:genetics*; D050259:Genes, Mitochondrial / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008297:Male; D009154:Mutation; D012729:Sex Chromosome Aberrations