Late onset of cholesterol crystal embolism after thrombolysis for cerebral infarction.
A 73-year-old man was admitted to our hospital because of bilateral foot pain. He was treated with thrombolysis for cerebral infarction about 5 months ago. Anticoagulants had not been used because of hemorrhagic infarction. The pulses of bilateral pedal arteries were palpable, but cyanosis was present in the bilateral toes. Laboratory data indicated azotemia and eosinophilia. Magnetic resonance imaging revealed multiple plaques of the thoracic and abdominal aorta, one of which was ulcerated. Skin biopsy proved the diagnosis of cholesterol crystal embolism (CCE). Because no invasive vascular procedure was performed, we assumed that CCE in this patient was related to thrombolysis. We should be cautious for late onset of CCE after thrombolysis.
Oe
Kotaro
K
Division of Internal Medicine, Saiseikai Kanazawa Hospital. kotarooe316@yahoo.co.jp
Araki
Tsutomu
T
Nakashima
Akikatsu
A
Sato
Katsuaki
K
Konno
Tetsuo
T
Yamagishi
Masakazu
M
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use; D000792:Angiography / Q000379:methods; D001707:Biopsy, Needle; D002544:Cerebral Infarction / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D017700:Embolism, Cholesterol / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy / Q000009:adverse effects* / Q000379:methods; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use; D014034:Toes / Q000473:pathology* / Q000503:physiopathology; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D010959:Tissue Plasminogen Activator; D000527:Alprostadil