title: Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population.
abstract: On the one hand, a suitable response to daily stressors is crucial for adequate functioning in any natural environment. On the other hand, depending on the individual's genetic makeup, prolonged stress that is accompanied by an inappropriate level of responsiveness may lead to physiological and psychiatric disorders. Several psychiatric conditions have been linked with stress and alterations in hypothalamic-pituitary-adrenal (HPA) activity. While stress is a general phenomenon, illness is only seen in a proportion of individuals, suggesting that genetic factors may play a role in the ability to cope with stress. In children, relatively little research has been conducted to determine the impact of genetic factors on the variability in HPA axis functioning. In the present exploratory investigation, 106 prepubertal children were studied to estimate the impact of four glucocorticoid receptor gene (NR3C1) polymorphisms (NR3C1-1 [rs10482605], ER22/23EK [rs6190], N363S [rs6195], N766N [rs6196]) and five arginine vasopressin (AVP) receptor 1b gene (AVPR1b) polymorphisms (AVPR1b_s1 [rs28536160], AVPR1b_s2 [rs28373064], AVPR1b_s3 [rs33976516], AVPR1b_s4 [rs33985287], AVPR1b_s5 [rs33933482]) on cortisol responses after a psychosocial stress test (public speaking task). ER22/23EK carriers had significantly lower cortisol responses to psychosocial stress compared with noncarriers. These findings provide evidence for the relevance of the ER22/23EK polymorphism in childhood HPA axis regulation. However, the small number of ER22/23EK subjects does not allow us to draw definitive conclusions about the genotypic effect.
authors.affiliation: Department of Molecular Genetics, Applied Molecular Genomics Group, VIB, Belgium. dirk.vanwest@zna.be
authors.forename: Dirk
authors.initials: D
authors.lastname: van West
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: Dirk
authors.initials: D
authors.lastname: Deboutte
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Stephan
authors.initials: S
authors.lastname: Claes
mesh_terms: D000704:Analysis of Variance; D019540:Area Under Curve; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008297:Male; D001523:Mental Disorders / Q000150:complications; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D017483:Receptors, Vasopressin / Q000235:genetics* / Q000378:metabolism; D013315:Stress, Psychological / Q000209:etiology / Q000235:genetics* / Q000473:pathology*
chemical_list: C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid; D017483:Receptors, Vasopressin; D006854:Hydrocortisone