title: [Inflammatory myofibroblastic tumor of the lymph node with paraneoplastic thrombosis and eosinophilia].
abstract: METHODS
  A 52-year-old female patient was admitted to hospital because of progressive thrombosis despite therapeutic anticoagulation as well as leukocytosis with eosinophilia and thrombocytopenia. On examination, the patient presented with dyspnea and swelling oft her left leg and arm. The laboratory findings revealed leukocytosis (31,000/microl) with eosinophilia (54%), thrombocytopenia (58,000/microl), together with an increased C-reactive protein of 247 mg/dl (reference range < 5 mg/dl). Initial computed tomography scans showed pulmonary embolism and a slightly enlarged left inguinal lymph node. Histological examination of the lymph node biopsy revealed in part an epitheloid and spindle cell-like tumorous lesion with slightly increased tissue eosinophilia consistent with an inflammatory myofibroblastic tumor (IMT). Resection of the left inguinal lymph node resulted in an immediate regression of the paraneoplastic eosinophilia and thrombocytopenia. Anti-inflammatory medication with ibuprofen was subsequently initiated. Imaging and clinical examination at 3 months after discharge revealed no relapse and no signs of a paraneoplastic syndrome.
  
  
  CONCLUSIONS
  The IMT is a rare soft-tissue tumor of intermediate dignity with a low tendency to metastasize. It is consistently accompanied by paraneoplastic syndromes. Therapy of choice is complete resection of the tumor. In nonresectable cases, corticosteroids and nonsteroidal antirheumatics have been shown to be effective. Because of the variable clinical course ranging from spontaneous regression to metastasis, IMTs might be separated into different entities (autoimmune, inflammatory, neoplastic subtype) which thus far cannot be classified on a histopathologic basis. A clinical assessment of the dignity is therefore important until further subclassifications of this rare disease become available.
authors.affiliation: Medizinische Klinik 5 - Hämatologie & Internistische Onkologie, Universitätsklinikum Erlangen, Erlangen, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Behzad
authors.forename: Andrea
authors.initials: A
authors.lastname: Müller
authors.forename: Wolf
authors.initials: W
authors.lastname: Rösler
authors.forename: Kerstin
authors.initials: K
authors.lastname: Amann
authors.forename: Rainer
authors.initials: R
authors.lastname: Linke
authors.forename: Andreas
authors.initials: A
authors.lastname: Mackensen
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007264:Inguinal Canal / Q000601:surgery; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D049268:Positron-Emission Tomography; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D019788:Fluorodeoxyglucose F18
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