title: [Feedback control of depth of anesthesia during propofol administration. Bispectral index as the controlled variable].
abstract: BACKGROUND
  The objective of this study was to evaluate the performance of a new system for closed-loop control of propofol administration using the bispectral index (BIS) under total intravenous anesthesia in the index values of middle-to-deep depth of anaesthesia.
  
  
  METHODS
  In this study 20 adult patients anesthetized with propofol and remifentanil were investigated. The propofol infusion was carried out using a fuzzy-PD+I controller with a target BIS value of 40.
  
  
  RESULTS
  Closed-loop control was able to provide maintenance of anesthesia and adequate operating conditions for all patients. The following quality control criteria were calculated: median performance error (MDPE; 0.16%, SD +/-1.4%), median absolute performance error (MDAPE; 6.9%, SD +/-2.8%) and wobble (6.8%, SD +/-2.5%).
  
  
  CONCLUSIONS
  The present study showed the clinical feasibility of the controller compared to existing devices regarding a high level of quality criteria of a model with an implemented fuzzy-PD+I structure controlling depth of hypnosis.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universität Rostock, Schillingallee 35, 18055 Rostock, Deutschland. matthias.janda@uni-rostock.de
authors.forename: M
authors.initials: M
authors.lastname: Janda
authors.forename: J
authors.initials: J
authors.lastname: Bajorat
authors.forename: O
authors.initials: O
authors.lastname: Simanski
authors.forename: R
authors.initials: R
authors.lastname: Kähler
authors.forename: B
authors.initials: B
authors.lastname: Pohl
authors.forename: G F E
authors.initials: GF
authors.lastname: Nöldge-Schomburg
authors.forename: R
authors.initials: R
authors.lastname: Hofmockel
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D056805:Consciousness Monitors; D004569:Electroencephalography; D005240:Feasibility Studies; D005246:Feedback; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines; D015742:Propofol; D011786:Quality Control; D011880:Radiotherapy Planning, Computer-Assisted; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol
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