[Mechanism of Chinese herbal medicine delaying glomerulosclerosis in diabetic nephropathy].
The pathomechanisms of glomerulosclerosis in diabetic nephropathy (DN) are considered to be related with glycometabolism disorder, podocyte injury, intra-renal hemodynamics abnormality, fibrogenic cytokines over-expression, oxidative stress and inflammatory reaction. Chinese herbal medicine could delay the progression of glomerulosclerosis in DN by ameliorating the harmful factors of these pathological changes. Therefore, it is possible to postpone the progress of DN to end-stage renal disease through the treatment with Chinese herbal medicine.
Chen
Jing
J
Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210008, China. ada47@sohu.com
Wan
Yigang
Y
Bian
Rongwen
R
Gu
Liubao
L
Wang
Chaojun
C
Zhang
Huilan
H
Yao
Jian
J
D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects
D004365:Drugs, Chinese Herbal