title: Lymphedema management in head and neck cancer.
abstract: OBJECTIVE
  Head and neck lymphedema (HNL) is a common and often debilitating cancer treatment effect that is under-researched and ill defined. We examined current literature and reviewed historical treatment approaches. We propose a model for evaluation and treatment of HNL used at The University of Texas M. D. Anderson Cancer Center (MDACC) for patients with head and neck cancer (HNC).
  
  
  RESULTS
  Despite the morbidity associated with HNL in patients with HNC, to our knowledge, no article has been published within the past 18 months whose primary focus is HNL. Eight publications included HNL but only as a secondary focus related to treatment effect, risk of dysphagia, prognostic indicator of underlying disease, and quality of life. A potential benefit of selenium treatment to reduce HNL was reported.
  
  
  CONCLUSIONS
  This article highlights the recent literature regarding HNL in patients treated for HNC. Although HNL is reported as a potential complication of HNC treatment, no clear definition of the disease or its management are published. Our early experience using an objective evaluation and treatment protocol holds promise for a better understanding of HNL in patients treated for head and neck malignancy.
authors.affiliation: Department of Head and Neck Surgery, Section of Speech-Language Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. bradgsmith@mdanderson.org
authors.forename: Brad G
authors.initials: BG
authors.lastname: Smith
authors.forename: Jan S
authors.initials: JS
authors.lastname: Lewin
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008209:Lymphedema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011788:Quality of Life / Q000523:psychology; D012643:Selenium / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D012643:Selenium
references.citation: Head Neck. 2004 Sep;26(9):785-91
references.pmid: 15350024
references.citation: J Cancer Res Clin Oncol. 2009 Jul;135(7):961-7
references.pmid: 19107519
references.citation: Molecules. 2009 Oct 12;14(10):3975-88
references.pmid: 19924043
references.citation: J Laryngol Otol. 2001 Jan;115(1):62-4
references.pmid: 11233630
references.citation: J Am Osteopath Assoc. 2005 Oct;105(10):457-64
references.pmid: 16314678
references.citation: Laryngoscope. 2009 May;119(5):915-23
references.pmid: 19358200
references.citation: J Surg Oncol. 1989 Jul;41(3):143-7
references.pmid: 2747242
references.citation: Wien Med Wochenschr. 2008;158(23-24):695-701
references.pmid: 19165449
references.citation: Int J Palliat Nurs. 2009 Apr;15(4):162, 164, 166-9
references.pmid: 19430411
references.citation: Support Care Cancer. 2010 Oct;18(10):1313-9
references.pmid: 19821167
references.citation: Otolaryngol Head Neck Surg. 2009 Aug;141(2):172-6
references.pmid: 19643247
references.citation: Z Lymphol. 1993 Aug;17(1):6-11
references.pmid: 8379251
references.citation: Laryngorhinootologie. 1998 Apr;77(4):207-12
references.pmid: 9592754
references.citation: Cancer. 1998 Dec 15;83(12 Suppl American):2840-2
references.pmid: 9874409
references.citation: Anticancer Res. 2007 Jul-Aug;27(4A):1953-6
references.pmid: 17649803
references.citation: Lymphology. 2007 Sep;40(3):138-42
references.pmid: 18062616
references.citation: Int J Dermatol. 2006 Dec;45(12):1468-70
references.pmid: 17184270
references.citation: Asthet Med (Berl). 1965 Jun 20;14(6):190-1
references.pmid: 5296225
references.citation: Am J Phys Med Rehabil. 2001 Apr;80(4):261-9
references.pmid: 11277132
references.citation: Radiother Oncol. 2008 May;87(2):253-9
references.pmid: 18410976
references.citation: Strahlenther Onkol. 2009 Oct;185(10):675-81
references.pmid: 19806333
references.citation: HNO. 1986 Sep;34(9):365-7
references.pmid: 2429943
references.citation: Semin Radiat Oncol. 2009 Jan;19(1):35-42
references.pmid: 19028344
references.citation: Semin Oncol Nurs. 2009 Aug;25(3):231-41
references.pmid: 19635402