title: Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression.
abstract: Misalignment between the timing of sleep and the circadian pacemaker has been linked to depression symptoms. This study sought to extend earlier findings by comparing sleep and circadian markers in healthy controls and individuals with major depression. Two markers of circadian misalignment correlated with depression severity in the depressed group.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Brant P
authors.initials: BP
authors.lastname: Hasler
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Buysse
authors.forename: David J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: Anne
authors.initials: A
authors.lastname: Germain
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003863:Depression / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012893:Sleep Wake Disorders / Q000209:etiology*; D055815:Young Adult
chemical_list: D008550:Melatonin
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