Fuzzy complexes of myelin basic protein: NMR spectroscopic investigations of a polymorphic organizational linker of the central nervous system.
The classic 18.5 kDa isoform of myelin basic protein (MBP) is central to maintaining the structural homeostasis of the myelin sheath of the central nervous system. It is an intrinsically disordered, promiscuous, multifunctional, peripheral membrane protein, whose conformation adapts to its particular environment. Its study requires the selective and complementary application of diverse approaches, of which solution and solid-state NMR spectroscopy are the most powerful to elucidate site-specific features. We review here several recent solution and solid-state NMR spectroscopic studies of 18.5 kDa MBP, and the induced partial disorder-to-order transitions that it has been demonstrated to undergo when complexed with calmodulin, actin, and phospholipid membranes.
Libich
David S
DS
Centre for Structural Biology, Institute of Fundamental Sciences, Department of Physics, Massey University, Palmerston North, New Zealand. d.s.libich@massey.ac.nz
Ahmed
Mumdooh A M
MA
Zhong
Ligang
L
Bamm
Vladimir V
VV
Ladizhansky
Vladimir
V
Harauz
George
G
D000818:Animals; D002490:Central Nervous System / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D004676:Myelin Basic Protein / Q000737:chemistry*; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry*
D004676:Myelin Basic Protein; D020033:Protein Isoforms
J Neurosci Res. 2000 Jan 15;59(2):153-9
10650873
J Biomol NMR. 1995 Jun;5(4):427-32
22911561
Biochemistry. 2009 Mar 24;48(11):2385-93
19178193
Prog Biophys Mol Biol. 1995;63(3):277-99
8599031
J Biomol NMR. 2004 Aug;29(4):545-6
15243191
J Neurochem. 1992 Nov;59(5):1589-608
1383423
J Mol Graph Model. 2001;19(1):26-59
11381529
Biochemistry. 2009 Sep 1;48(34):8094-104
19642704
J Mol Biol. 2009 Mar 6;386(4):1078-93
19244620
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4422-7
16537438
Curr Opin Struct Biol. 2005 Feb;15(1):35-41
15718131
J Mol Biol. 2002 Sep 6;322(1):163-78
12215422
J Am Chem Soc. 2004 Jun 2;126(21):6720-7
15161300
J Biol Chem. 2003 Aug 1;278(31):29041-7
12748174
Protein Sci. 2002 Mar;11(3):529-37
11847276
Protein Sci. 2003 Jan;12(1):1-16
12493823
Chem Rev. 2004 Aug;104(8):3623-40
15303831
Biochem Cell Biol. 1998;76(2-3):153-63
9923684
J Struct Biol. 2004 Dec;148(3):353-69
15522783
IUBMB Life. 2006 Feb;58(2):107-9
16608823
Nat Rev Mol Cell Biol. 2005 Mar;6(3):197-208
15738986
Science. 1993 Jun 4;260(5113):1491-6
8502992
Biophys J. 2007 Mar 1;92(5):1439-56
17158572
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10695-9
7504278
Biopolymers. 1999;51(3):191-207
10516571
J Am Chem Soc. 2001 Apr 4;123(13):2970-8
11457007
J Magn Reson. 2001 Feb;148(2):459-64
11237654
J Am Chem Soc. 2009 Jun 17;131(23):8108-20
19445506
Eur Biophys J. 2008 Jul;37(6):1015-29
18449534
Science. 2001 Jul 20;293(5529):487-9
11463915
Biochemistry. 2008 Jan 8;47(1):267-82
18067320
J Mol Biol. 2007 Sep 14;372(2):549-61
17681540
FEBS Lett. 1997 Dec 15;419(2-3):285-9
9428652
J Biomol NMR. 2000 Sep;18(1):43-8
11061227
Protein Sci. 2008 Feb;17(2):199-204
18227427
Cell Mol Life Sci. 2006 Sep;63(17):1945-61
16794783
FEBS J. 2006 Feb;273(3):601-14
16420483
Biochim Biophys Acta. 2007 Dec;1768(12):3193-205
17920035
Micron. 2004;35(7):503-42
15219899
Curr Opin Struct Biol. 2008 Dec;18(6):756-64
18952168
J Am Chem Soc. 2008 Jun 25;130(25):7804-5
18512919
Chemphyschem. 2009 Jul 13;10(9-10):1415-9
19462392
J Mol Recognit. 2010 Mar-Apr;23(2):105-16
19585546
Biomol NMR Assign. 2007 Jul;1(1):61-3
19636827
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10165-70
19509339
Curr Opin Struct Biol. 2009 Feb;19(1):23-30
19162471
J Biol Chem. 2004 Feb 13;279(7):5757-64
14630913
Biochemistry. 2006 Jun 6;45(22):6873-88
16734424
Protein Sci. 2006 Dec;15(12):2795-804
17088319
FEBS Lett. 2005 Jun 13;579(15):3346-54
15943980
Curr Protein Pept Sci. 2009 Jun;10(3):196-215
19519451
Cell. 2002 Mar 22;108(6):739-42
11955428
Neurochem Res. 2007 Feb;32(2):213-28
17031566
IUBMB Life. 2001 Dec;52(6):291-302
11895078
Curr Opin Struct Biol. 2009 Feb;19(1):31-8
19157855
Proteins. 2006 Jan 1;62(1):24-45
16287116
Int Rev Neurobiol. 2007;79:149-72
17531841
Annu Rev Biochem. 2004;73:107-46
15189138
J Biomol NMR. 2006 Sep;36(1):55-71
16964530
Chem Rev. 2004 Aug;104(8):3607-22
15303830
FEBS Lett. 1994 Aug 15;350(1):87-90
8062930
Dis Model Mech. 2008 Nov-Dec;1(4-5):229-40
19093029
Bioessays. 2009 Mar;31(3):328-35
19260013
Biochem Cell Biol. 2002;80(4):395-406
12234092
Adv Protein Chem. 2002;62:1-23
12418099
J Am Chem Soc. 2006 Oct 4;128(39):12620-1
17002335
J Mol Biol. 1997 Apr 25;268(1):158-69
9149149
Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3878-81
16646097
Biophys J. 2008 Jun;94(12):4847-66
18326633
Trends Biochem Sci. 2008 Jan;33(1):2-8
18054235
Protein Sci. 2003 Jul;12(7):1507-21
12824496
J Proteome Res. 2007 Jun;6(6):2351-66
17488107
Biophys J. 2009 Jan;96(1):180-91
19134474
Neurochem Res. 2007 Feb;32(2):251-6
17031564
J Mol Biol. 2006 Oct 6;362(5):1043-59
16935303
J Am Chem Soc. 2006 Oct 11;128(40):13224-8
17017802
Biochem Biophys Res Commun. 2003 Aug 22;308(2):313-9
12901870