title: Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
abstract: Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Sherborne
authors.forename: Fay J
authors.initials: FJ
authors.lastname: Hosking
authors.forename: Rashmi B
authors.initials: RB
authors.lastname: Prasad
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar
authors.forename: Rolf
authors.initials: R
authors.lastname: Koehler
authors.forename: Jayaram
authors.initials: J
authors.lastname: Vijayakrishnan
authors.forename: Elli
authors.initials: E
authors.lastname: Papaemmanuil
authors.forename: Claus R
authors.initials: CR
authors.lastname: Bartram
authors.forename: Martin
authors.initials: M
authors.lastname: Stanulla
authors.forename: Martin
authors.initials: M
authors.lastname: Schrappe
authors.forename: Andreas
authors.initials: A
authors.lastname: Gast
authors.forename: Sara E
authors.initials: SE
authors.lastname: Dobbins
authors.forename: Yussanne
authors.initials: Y
authors.lastname: Ma
authors.forename: Eamonn
authors.initials: E
authors.lastname: Sheridan
authors.forename: Malcolm
authors.initials: M
authors.lastname: Taylor
authors.forename: Sally E
authors.initials: SE
authors.lastname: Kinsey
authors.forename: Tracey
authors.initials: T
authors.lastname: Lightfoot
authors.forename: Eve
authors.initials: E
authors.lastname: Roman
authors.forename: Julie A E
authors.initials: JA
authors.lastname: Irving
authors.forename: James M
authors.initials: JM
authors.lastname: Allan
authors.forename: Anthony V
authors.initials: AV
authors.lastname: Moorman
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Harrison
authors.forename: Ian P
authors.initials: IP
authors.lastname: Tomlinson
authors.forename: Sue
authors.initials: S
authors.lastname: Richards
authors.forename: Martin
authors.initials: M
authors.lastname: Zimmermann
authors.forename: Csaba
authors.initials: C
authors.lastname: Szalai
authors.forename: Agnes F
authors.initials: AF
authors.lastname: Semsei
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Erdelyi
authors.forename: Maja
authors.initials: M
authors.lastname: Krajinovic
authors.forename: Daniel
authors.initials: D
authors.lastname: Sinnett
authors.forename: Jasmine
authors.initials: J
authors.lastname: Healy
authors.forename: Anna
authors.initials: A
authors.lastname: Gonzalez Neira
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kawamata
authors.forename: Seishi
authors.initials: S
authors.lastname: Ogawa
authors.forename: H Phillip
authors.initials: HP
authors.lastname: Koeffler
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.forename: Mel
authors.initials: M
authors.lastname: Greaves
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
references.citation: Nat Genet. 2009 Sep;41(9):1001-5
references.pmid: 19684603
references.citation: Science. 2007 Jun 1;316(5829):1341-5
references.pmid: 17463248
references.citation: Nat Genet. 2009 Aug;41(8):899-904
references.pmid: 19578367
references.citation: Haematologica. 2006 Jul;91(7):881-5
references.pmid: 16818274
references.citation: Leukemia. 2009 Jul;23(7):1209-18
references.pmid: 19242497
references.citation: Blood. 2009 Jan 1;113(1):100-7
references.pmid: 18838613
references.citation: Nat Genet. 2009 Aug;41(8):909-14
references.pmid: 19578363
references.citation: Nat Genet. 2009 Sep;41(9):1006-10
references.pmid: 19684604
references.citation: PLoS Genet. 2005 Dec;1(6):e78
references.pmid: 16362079
references.citation: Leukemia. 2010 Jan;24(1):66-73
references.pmid: 19759560
references.citation: Science. 2007 Jun 8;316(5830):1488-91
references.pmid: 17478681
references.citation: J Biol Chem. 2002 Nov 29;277(48):46289-97
references.pmid: 12228235
references.citation: Nat Genet. 2009 Aug;41(8):915-9
references.pmid: 19578365
references.citation: Nat Genet. 2009 Aug;41(8):920-5
references.pmid: 19578364