title: ZAP-70: an essential kinase in T-cell signaling.
abstract: ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
authors.affiliation: Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
authors.forename: Haopeng
authors.initials: H
authors.lastname: Wang
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Kadlecek
authors.forename: Byron B
authors.initials: BB
authors.lastname: Au-Yeung
authors.forename: Hanna E Sjölin
authors.initials: HE
authors.lastname: Goodfellow
authors.forename: Lih-Yun
authors.initials: LY
authors.lastname: Hsu
authors.forename: Tanya S
authors.initials: TS
authors.lastname: Freedman
authors.forename: Arthur
authors.initials: A
authors.lastname: Weiss
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D010766:Phosphorylation; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology*; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D011948:Receptors, Antigen, T-Cell; D051746:ZAP-70 Protein-Tyrosine Kinase
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