Biodegradable therapeutic MOFs for the delivery of bioactive molecules.
A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.
Miller
Stuart R
SR
Institut Lavoisier, UMR CNRS 8180, University of Versailles-St. Quentin-en-Yvelines, 45, Avenue des Etats-Unis, 78035, Versailles, France.
Heurtaux
Daniela
D
Baati
Tarek
T
Horcajada
Patricia
P
Grenèche
Jean-Marc
JM
Serre
Christian
C
D018360:Crystallography, X-Ray; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D007501:Iron / Q000737:chemistry*; D008958:Models, Molecular; D009525:Niacin / Q000737:chemistry*; D013696:Temperature
D005290:Ferric Compounds; D009525:Niacin; D007501:Iron