The origin of biological homochirality.
The single-handedness of biological molecules has fascinated scientists and laymen alike since Pasteur's first painstaking separation of the enantiomorphic crystals of a tartrate salt more than 150 yr ago. More recently, a number of theoretical and experimental investigations have helped to delineate models for how one enantiomer might have come to dominate over the other from what presumably was a racemic prebiotic world. This article highlights mechanisms for enantioenrichment that include either chemical or physical processes, or a combination of both. The scientific driving force for this work arises from an interest in understanding the origin of life, because the homochirality of biological molecules is a signature of life.
Blackmond
Donna G
DG
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA. blackmond@scripps.edu
D000596:Amino Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D002241:Carbohydrates
J Am Chem Soc. 2003 Jul 30;125(30):8978-9
15369330
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5732-6
15067112
Astrobiology. 2007 Apr;7(2):312-9
17480162
J Am Chem Soc. 2008 Nov 19;130(46):15274-5
18954052
J Am Chem Soc. 2007 Jun 20;129(24):7657-60
17530759
Chem Commun (Camb). 2007 Oct 21;(39):3990-6
17912393
Angew Chem Int Ed Engl. 1972 Sep;11(9):798-820
4628613
Angew Chem Int Ed Engl. 2007;46(3):393-6
17146824
Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7985-9
16986192
Science. 1990 Nov 16;250(4983):975-6
17746924
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15131-5
19416826
Chem Commun (Camb). 2007 Jul 7;(25):2578-80
17579743
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9144-6
19478058
Phys Rev Lett. 2005 Feb 18;94(6):065504
15783745
Angew Chem Int Ed Engl. 2009;48(3):590-4
19072810
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):12979-80
16938839
Science. 2009 Apr 24;324(5926):492-5
19325079
Angew Chem Int Ed Engl. 2002 Dec 16;41(24):4618-30
12481315
Cold Spring Harb Perspect Biol. 2010 May;2(5):a002162
20452963
Science. 2002 Feb 15;295(5558):1266-9
11786606
Ann N Y Acad Sci. 1957 Aug 30;69(2):352-68
13479013
Nature. 2006 Jun 1;441(7093):621-3
16738656
Angew Chem Int Ed Engl. 1998 Nov 16;37(21):2922-2959
29711141
J Am Chem Soc. 2008 Jan 30;130(4):1158-9
18173274
Chemistry. 2009;15(13):3065-8
19222072
Acc Chem Res. 2006 Apr;39(4):231-7
16618090
Chem Commun (Camb). 2007 Mar 14;(10):1071-3
17325809
Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a004895
20573713
J Am Chem Soc. 2001 Oct 17;123(41):10103-4
11592892
Biochim Biophys Acta. 1953 Aug;11(4):459-63
13105666
J Theor Biol. 1969 Dec;25(3):491-4
5387052