title: Associations between personality traits and CCK-4-induced panic attacks in healthy volunteers.
abstract: In this study we examined how personality disposition may affect the response to cholecystokinin tetrapeptide (CCK-4; 50 microg) challenge in healthy volunteers (n=105). Personality traits were assessed with the Swedish universities Scales of Personality (SSP). Statistical methods employed were correlation analysis and logistic regression. The results showed that the occurrence of CCK-4-induced panic attacks was best predicted by baseline diastolic blood pressure, preceding anxiety and SSP-defined traits of lack of assertiveness, detachment, embitterment and verbal aggression. Significant interactions were noted between the above mentioned variables, modifying their individual effects. For different subsets of CCK-4-induced symptoms, the traits of physical aggression, irritability, somatic anxiety and stress susceptibility also appeared related to panic manifestations. These findings suggest that some personality traits and their interactions may influence vulnerability to CCK-4-induced panic attacks in healthy volunteers.
authors.affiliation: Department of Psychiatry, University of Tartu, Tartu, Estonia. Innar.Toru@kliinikum.ee
authors.forename: Innar
authors.initials: I
authors.lastname: Tõru
authors.forename: Anu
authors.initials: A
authors.lastname: Aluoja
authors.forename: Ulle
authors.initials: U
authors.lastname: Võhma
authors.forename: Mait
authors.initials: M
authors.lastname: Raag
authors.forename: Veiko
authors.initials: V
authors.lastname: Vasar
authors.forename: Eduard
authors.initials: E
authors.lastname: Maron
authors.forename: Jakov
authors.initials: J
authors.lastname: Shlik
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000139:chemically induced* / Q000523:psychology*; D010551:Personality; D010555:Personality Inventory; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D013758:Tetragastrin; D055815:Young Adult
chemical_list: D013758:Tetragastrin