title: The role of CCR5 in HCV infection.
abstract: Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes. The CCR5 chemokine receptor is expressed on several cells of the immune system and has been suggested to influence the susceptibility to HCV infection as well as natural course and progression of hepatitis C. However, these reports are still controversial. This review will summarize and discuss the available data regarding the potential role of CCR5 and its ligands in hepatitis C.
authors.affiliation: Department of Internal Medicine I, University of Bonn, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Coenen
authors.forename: Jacob
authors.initials: J
authors.lastname: Nattermann
mesh_terms: D018946:Chemokine CCL5 / Q000502:physiology*; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D006801:Humans; D019713:Receptors, CCR5 / Q000502:physiology*
chemical_list: D018946:Chemokine CCL5; D019713:Receptors, CCR5
references.citation: Virology. 2002 Nov 25;303(2):253-77
references.pmid: 12490388
references.citation: Am J Transplant. 2008 Mar;8(3):557-66
references.pmid: 18294152
references.citation: Pharmacol Rev. 2000 Mar;52(1):145-76
references.pmid: 10699158
references.citation: J Infect Dis. 2008 Jul 15;198(2):213-7
references.pmid: 18500933
references.citation: J Am Soc Nephrol. 2002 Mar;13(3):754-758
references.pmid: 11856781
references.citation: Nat Rev Cancer. 2004 Jul;4(7):540-50
references.pmid: 15229479
references.citation: Hepatology. 2003 Dec;38(6):1468-76
references.pmid: 14647058
references.citation: Am J Gastroenterol. 2002 Nov;97(11):2861-70
references.pmid: 12425561
references.citation: Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G949-58
references.pmid: 12829440
references.citation: J Exp Med. 2006 Jan 23;203(1):35-40
references.pmid: 16418398
references.citation: J Hepatol. 2010 Feb;52(2):153-9
references.pmid: 20044164
references.citation: Nat Immunol. 2001 Feb;2(2):108-15
references.pmid: 11175802
references.citation: Autoimmun Rev. 2002 Dec;1(6):313-20
references.pmid: 12848986
references.citation: Clin Infect Dis. 2009 Aug 1;49(3):466-72
references.pmid: 19580412
references.citation: J Viral Hepat. 2004 Jul;11(4):319-23
references.pmid: 15230854
references.citation: Eur J Immunogenet. 2004 Dec;31(6):249-52
references.pmid: 15548261
references.citation: Nat Immunol. 2007 Dec;8(12):1324-36
references.pmid: 17952079
references.citation: Gastroenterology. 2000 Feb;118(2):346-55
references.pmid: 10648463
references.citation: Lancet. 2001 Jun 2;357(9270):1758-61
references.pmid: 11403814
references.citation: Nature. 1998 Jan 22;391(6665):344-5
references.pmid: 9450746
references.citation: J Immunol. 1998 Apr 15;160(8):4018-25
references.pmid: 9558111
references.citation: Immunol Invest. 2009;38(1):1-13
references.pmid: 19172482
references.citation: Gastroenterology. 2002 Jun;122(7):1721-8
references.pmid: 12055576
references.citation: Hepatology. 2006 Oct;44(4):945-54
references.pmid: 17006905
references.citation: Science. 1996 Sep 27;273(5283):1856-62
references.pmid: 8791590
references.citation: J Clin Invest. 2009 Jul;119(7):1858-70
references.pmid: 19603542
references.citation: Clin Immunol. 2003 Jul;108(1):46-50
references.pmid: 12865070
references.citation: Transplantation. 2007 Oct 27;84(8):1037-44
references.pmid: 17989610
references.citation: J Antimicrob Chemother. 2004 Jun;53(6):895-8
references.pmid: 15128728
references.citation: Gut. 2005 Aug;54(8):1157-61
references.pmid: 15863470
references.citation: Nat Immunol. 2001 Feb;2(2):95-101
references.pmid: 11175800
references.citation: Hepatology. 2005 Oct;42(4):854-62
references.pmid: 16175603
references.citation: Transplantation. 2004 Nov 15;78(9):1341-50
references.pmid: 15548973
references.citation: Circ Res. 2004 Oct 29;95(9):858-66
references.pmid: 15514167
references.citation: Blood. 2002 Feb 15;99(4):1237-45
references.pmid: 11830471
references.citation: World J Gastroenterol. 2006 Aug 7;12(29):4721-6
references.pmid: 16937446
references.citation: J Hepatol. 2003 Aug;39(2):245-52
references.pmid: 12873822
references.citation: Cell. 1996 Aug 9;86(3):367-77
references.pmid: 8756719
references.citation: J Immunol. 1999 Dec 1;163(11):6236-43
references.pmid: 10570316
references.citation: EMBO J. 2006 Feb 8;25(3):447-56
references.pmid: 16437164
references.citation: J Clin Invest. 1996 Aug 1;98(3):706-14
references.pmid: 8698862
references.citation: J Immunol. 2004 Sep 1;173(5):3287-96
references.pmid: 15322191
references.citation: J Mol Med (Berl). 2004 Jan;82(1):64-9
references.pmid: 14673528