A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes.
Cytotoxic T lymphocytes (CTLs) play a critical role in the control of various cancers and infections, and therefore the molecular mechanisms of CTL generation are a critical issue in designing antitumor immunotherapy and vaccines which augment the development of functional and long-lasting memory CTLs. Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, acts on naive CD4+ T cells and plays pivotal roles as a proinflammatory cytokine to promote the early initiation of type-1 helper differentiation and also as an antiinflammatory cytokine to limit the T cell hyperactivity and production of pro-inflammatory cytokines. Recent studies revealed that IL-27 plays an important role in CD8+ T cells as well. Therefore, this article reviews current understanding of the role of IL-27 in CD8+ T cell functions and generation of CTLs.
Morishima
Noriko
N
Intractable Disease Research Center, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
Mizoguchi
Izuru
I
Okumura
Masae
M
Chiba
Yukino
Y
Xu
Mingli
M
Shimizu
Motomu
M
Matsui
Masanori
M
Mizuguchi
Junichiro
J
Yoshimoto
Takayuki
T
D000818:Animals; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D020381:Interleukin-17 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D009928:Organ Specificity / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology* / Q000276:immunology*
D020381:Interleukin-17; D007371:Interferon-gamma
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