title: Massive eosinophilic pleural effusion preceding vasculitic symptoms in Churg-Strauss syndrome.
abstract: We report a case of Churg-Strauss syndrome (CSS) presenting as a massive pleural effusion. A 52-year-old asthmatic Japanese woman presented with progressive dyspnea caused by an eosinophilic pleural effusion (EPE). She also had chronic sinusitis, skin lesions and blood eosinophilia, but no antineutrophil cytoplasmic antibodies. Skin biopsy and the late onset of mononeuritis multiplex led to the diagnosis of CSS. The pleural effusion resolved soon after corticosteroid treatment was started. CSS is rare as a cause of EPE, but should be included in the differential diagnosis of EPE in asthmatic patients. This is the first report showing that EPE can precede other vasculitic symptoms in CSS.
authors.affiliation: Department of Respiratory Medicine, Tenri Hospital. tanizawa@kuhp.kyoto-u.ac.jp
authors.forename: Kiminobu
authors.initials: K
authors.lastname: Tanizawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kaji
authors.forename: Eisaku
authors.initials: E
authors.lastname: Tanaka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Inoue
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuramoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Minakuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Maeda
authors.forename: Ko
authors.initials: K
authors.lastname: Maniwa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Terada
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Goto
authors.forename: Tomoshi
authors.initials: T
authors.lastname: Takeda
authors.forename: Masaki
authors.initials: M
authors.lastname: Okamoto
authors.forename: Seishu
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noma
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kobashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Taguchi
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy; D001707:Biopsy, Needle; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D004802:Eosinophilia / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis* / Q000188:drug therapy; D013902:Radiography, Thoracic; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones