Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue?
The aims of this study is to evaluate the presence of estrogen receptors alpha (ERα) in thyroid lesions and to assess the practicality of this test in view of numerous disagreements on the subject. Immunohistochemical stains were performed for ERα, for the evaluation of immunoreactivity in 296 pathological thyroid tissue samples. We evaluated the intensity of the nuclear and cytoplasmatic staining and the spread of the stain over the sample. Thirty cases of the breast cancer served as a control group. None of the histological thyroid samples showed immunoreactivity for ERα. No difference was found between the various lesions in regard to this absence. The ERα rate of expression in the breast cancer samples was 60%. The ERα is undetectable in the histological samples of benign and malignant thyroid lesions. Further investigation is necessary in the laboratory immunohistochemical workup in order to exclude a possibility of non-specific staining.
Vaiman
Michael
M
Department of Otorhinolaryngology-Head and Neck Surgery, Assaf HaRofeh Medical Center affiliated to Sackler Medical School, Tel-Aviv University, Zerifin, Israel. vaimed@yahoo.com
Olevson
Youlian
Y
Sandbank
Judith
J
Habler
Liliana
L
Zehavi
Sergei
S
Kessler
Alex
A
D000328:Adult; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D013965:Thyroidectomy
D047628:Estrogen Receptor alpha
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