title: Superinfection during treatment of nosocomial infections with tigecycline.
abstract: We performed a retrospective and observational study of 51 patients treated with tigecycline, as the treatment for nosocomial infections due to multidrug-resistant microorganisms, to evaluate the superinfection rate and their etiologies. Superinfections were diagnosed in 12 (23.5%) patients (seven due to Pseudomonas aeruginosa, 13.7%) and one patient had P. aeruginosa colonization. Five patients with superinfection died (41.6%), three due to superinfections and two to underlying diseases. The superinfection rate observed during tigecycline treatment is higher than that previously reported. Pseudomonas aeruginosa is the most frequent agent, being the cause of 58.5% of all superinfections.
authors.affiliation: The Spanish Network for Research in Infectious Diseases, Hospitales Universitarios Virgen del Rocío, Av. Manuel Siurot s/n, 41013 Seville, Spain.
authors.forename: E
authors.initials: E
authors.lastname: García-Cabrera
authors.forename: M E
authors.initials: ME
authors.lastname: Jiménez-Mejías
authors.forename: M V
authors.initials: MV
authors.lastname: Gil Navarro
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez-Gómez
authors.forename: C
authors.initials: C
authors.lastname: Ortiz-Leyba
authors.forename: E
authors.initials: E
authors.lastname: Cordero
authors.forename: J
authors.initials: J
authors.lastname: Pachón
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015995:Prevalence; D012189:Retrospective Studies; D015163:Superinfection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
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