title: Evaluation of flavoglaucin, its derivatives and pyranonigrins produced by molds used in fermented foods for inhibiting tumor promotion.
abstract: Flavoglaucin, its derivatives, and pyranonigrins, which are antioxidants produced by the molds used in fermented foods, were examined for their inhibition of tumor promotion by the Epstein-Barr virus early antigen activation test. Flavoglaucin and its derivatives exhibited high activity. Flavoglaucin and such a derivative as isodihydroauroglaucin inhibited mouse skin tumor promotion in a two-stage carcinogenesis test and appear to be antitumor promoters.
authors.affiliation: Faculty of Human Wellness, Tokaigakuen University, Nagoya, Japan. miyakeyo@tokaigakuen-u.ac.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Miyake
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Osawa
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D005285:Fermentation; D005516:Food Microbiology; D005658:Fungi / Q000378:metabolism*; D005841:Gentisates / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000276:immunology; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D011753:Pyrones / Q000378:metabolism / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000821:virology
chemical_list: D000956:Antigens, Viral; D000975:Antioxidants; D005841:Gentisates; D011753:Pyrones; C005001:flavoglaucin