Actin in dendritic spines: connecting dynamics to function.
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses and are major sites of information processing and storage in the brain. Changes in the shape and size of dendritic spines are correlated with the strength of excitatory synaptic connections and heavily depend on remodeling of its underlying actin cytoskeleton. Emerging evidence suggests that most signaling pathways linking synaptic activity to spine morphology influence local actin dynamics. Therefore, specific mechanisms of actin regulation are integral to the formation, maturation, and plasticity of dendritic spines and to learning and memory.
Hotulainen
Pirta
P
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland. pirta.hotulainen@helsinki.fi
Hoogenraad
Casper C
CC
D000199:Actins / Q000378:metabolism*; D000818:Animals; D049229:Dendritic Spines / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology; D015398:Signal Transduction; D013569:Synapses / Q000378:metabolism
D000199:Actins
Nature. 1997 Jan 30;385(6615):439-42
9009191
Nature. 2006 Jun 22;441(7096):979-83
16791195
J Neurosci. 2009 Mar 4;29(9):2926-37
19261888
Mol Cell Biol. 2004 Dec;24(24):10905-22
15572692
Curr Opin Neurobiol. 2008 Oct;18(5):532-40
18832033
Nature. 2009 Mar 19;458(7236):299-304
19295602
J Biol Chem. 2009 Jan 9;284(2):1252-66
18945678
Neuroscience. 2010 Jan 13;165(1):138-50
19837137
J Neurosci. 2008 May 28;28(22):5654-9
18509026
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13713-8
19666512
Eur J Neurosci. 2005 Jan;21(1):15-25
15654839
Nature. 2006 Aug 17;442(7104):814-7
16862120
Prog Neurobiol. 2005 Feb;75(3):161-205
15882774
J Cell Biol. 2009 Apr 20;185(2):323-39
19380880
J Neurosci. 2005 Mar 30;25(13):3379-88
15800193
Mol Biol Cell. 2005 May;16(5):2349-62
15743906
Mol Biol Cell. 2005 Feb;16(2):649-64
15548599
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6418-23
17404223
Nat Rev Mol Cell Biol. 2006 Oct;7(10):713-26
16990851
Nature. 2010 Feb 18;463(7283):948-52
20164928
Neuron. 2003 May 8;38(3):447-60
12741991
Nat Neurosci. 2010 Mar;13(3):327-32
20139976
Nature. 2002 Dec 19-26;420(6917):812-6
12490949
Cell Motil Cytoskeleton. 2009 Aug;66(8):606-17
19459187
Nat Cell Biol. 2007 Dec;9(12):1347-59
18026093
Nat Rev Neurosci. 2002 Mar;3(3):175-90
11994750
J Neurosci. 2009 Sep 30;29(39):12167-73
19793974
Nat Neurosci. 2004 Sep;7(9):917-8
15322548
J Neurosci. 2008 Dec 10;28(50):13673-83
19074040
Annu Rev Biophys Biomol Struct. 2000;29:545-76
10940259
Mol Biol Cell. 2010 Jan 1;21(1):165-76
19889835
Physiol Rev. 2008 Apr;88(2):489-513
18391171
Mol Cell Proteomics. 2006 Jun;5(6):1158-70
16507876
J Biol Chem. 2008 Jun 6;283(23):15912-20
18430734
Neuron. 2009 Jan 15;61(1):85-100
19146815
Neuron. 2007 Nov 8;56(3):441-55
17988629
Science. 2005 Nov 4;310(5749):866-9
16272125
Cell. 2008 Oct 31;135(3):535-48
18984164
Trends Neurosci. 2000 Apr;23(4):141-6
10717670
Nat Rev Neurosci. 2009 Sep;10(9):647-58
19693029
Nat Neurosci. 2003 Nov;6(11):1194-200
14555951
Cell. 2010 Feb 19;140(4):579-89
20178749
Nat Genet. 1998 Sep;20(1):25-30
9731525
Nat Rev Neurosci. 2009 May;10(5):319-32
19377501
J Cell Biol. 1983 Oct;97(4):1169-78
6684661
Neuron. 2002 Oct 24;36(3):435-49
12408846
Neuron. 2008 Mar 13;57(5):719-29
18341992
J Neurosci. 2003 Dec 17;23(37):11759-69
14684878
J Neurosci. 1998 Apr 1;18(7):2423-36
9502803
Annu Rev Neurosci. 2001;24:1071-89
11520928
Hippocampus. 2006;16(2):183-97
16358313
Nature. 2004 Jun 17;429(6993):761-6
15190253
J Cell Sci. 2006 Oct 1;119(Pt 19):4127-37
16968742
Neuron. 2002 Jul 3;35(1):121-33
12123613
Annu Rev Cell Dev Biol. 2002;18:601-35
12142283
Curr Opin Neurobiol. 2008 Oct;18(5):524-31
18834940
Cell. 2003 Feb 21;112(4):453-65
12600310
J Neurosci. 2004 Oct 6;24(40):8862-72
15470153
Trends Neurosci. 2006 Jan;29(1):8-20
16337695
Cell Signal. 2009 Mar;21(3):384-93
19036346
J Neurochem. 2009 Jul;110(1):92-105
19453375
Nat Neurosci. 2006 Feb;9(2):234-42
16415866
J Cell Biol. 2005 Jan 17;168(2):329-38
15657400
EMBO J. 2007 Jun 20;26(12):2843-55
17525734
Nat Rev Neurosci. 2008 May;9(5):344-56
18425089
Mol Brain. 2009 Aug 04;2:25
19653898
Dev Neurobiol. 2009 Mar;69(4):221-34
19160442
Curr Biol. 2010 Feb 23;20(4):290-9
20137950
J Cell Biol. 2009 Jul 13;186(1):85-97
19596849
Science. 2000 Oct 27;290(5492):754-8
11052932
Nat Neurosci. 2000 Sep;3(9):887-94
10966619
J Neurosci. 2007 Jul 25;27(30):8031-9
17652593
Annu Rev Biochem. 2007;76:823-47
17243894
J Cell Biol. 2007 May 7;177(3):465-76
17470633
Nat Neurosci. 2006 Apr;9(4):481-3
16547510
Nat Neurosci. 2002 Mar;5(3):239-46
11850630
Nat Rev Neurosci. 2004 Jan;5(1):45-54
14708003
J Neurosci. 2007 May 16;27(20):5363-72
17507558
Nat Rev Neurosci. 2005 Jun;6(6):423-34
15928715
Curr Biol. 2009 Jan 27;19(2):95-107
19150238
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6
11274401
J Neurobiol. 2005 Jul;64(1):58-74
15884002
Curr Opin Neurobiol. 2009 Apr;19(2):146-53
19523814
J Neurosci. 2007 Jan 10;27(2):355-65
17215396
Annu Rev Neurosci. 2008;31:47-67
18284372
Neuron. 2006 Dec 7;52(5):817-30
17145503
J Neurosci. 2008 Oct 1;28(40):10031-44
18829961
PLoS One. 2009 May 25;4(5):e5678
19479071
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12411-6
16894163
Neuron. 2009 Jul 16;63(1):92-105
19607795
Neuron. 1998 May;20(5):847-54
9620690
Trends Neurosci. 2003 Jul;26(7):360-8
12850432
Neuron. 2007 Sep 20;55(6):874-89
17880892
PLoS One. 2008 Jan 09;3(1):e1407
18183288
Neuron. 2003 Jun 5;38(5):773-84
12797961
J Neurosci. 2005 Jan 26;25(4):869-79
15673667
J Neurosci. 2005 Sep 28;25(39):8878-88
16192377
Neuron. 2006 Jan 19;49(2):175-82
16423692
J Neurosci. 2006 Jul 19;26(29):7693-706
16855097
J Cell Biol. 2007 Jun 4;177(5):829-41
17548511
Nature. 2008 Oct 16;455(7215):903-11
18923512
Nature. 2002 Dec 19-26;420(6917):788-94
12490942
PLoS Biol. 2009 Jun 30;7(6):e1000138
19564905
Curr Biol. 2007 Oct 23;17(20):1752-8
17935993
Annu Rev Physiol. 2002;64:313-53
11826272
Trends Cell Biol. 2009 May;19(5):218-27
19328694
Nat Neurosci. 2004 Oct;7(10):1104-12
15361876
Trends Neurosci. 2010 Mar;33(3):121-9
20138375
Biol Psychiatry. 2004 Jun 15;55(12):1121-7
15184030
Nat Cell Biol. 2008 Jul;10(7):849-57
18516090
J Cell Biol. 2006 May 8;173(3):383-94
16651381
Science. 2004 Sep 24;305(5692):1972-5
15448273
J Cell Sci. 2007 Jan 15;120(Pt 2):205-12
17215449
Curr Opin Neurobiol. 2006 Feb;16(1):95-101
16361095
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6856-61
10823894
Biochem Biophys Res Commun. 2009 Jun 19;384(1):55-60
19393616
Trends Cell Biol. 2009 Dec;19(12):669-76
19801190
J Biol Chem. 2007 Aug 10;282(32):23005-9
17576764
J Cell Sci. 2009 Feb 15;122(Pt 4):524-34
19174472
Hippocampus. 2000;10(5):501-11
11075821
PLoS One. 2009 Nov 09;4(11):e7724
19898630
Nat Neurosci. 2002 Nov;5(11):1117-8
12389031
Nat Neurosci. 2009 Jul;12(7):823-5
19503086
Cell. 2004 Aug 6;118(3):363-73
15294161
J Cell Biol. 2007 Oct 22;179(2):229-38
17954606
Trends Neurosci. 2008 Sep;31(9):487-94
18684518