title: Roles of the NF-kappaB pathway in lymphocyte development and function.
abstract: This article focuses on the functions of NF-kappaB that vitally impact lymphocytes and thus adaptive immunity. NF-kappaB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kappaB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kappaB executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-kappaB's physiologic impact that we address in this article.
authors.affiliation: The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia. gerondakis@burnet.edu.au
authors.forename: Steve
authors.initials: S
authors.lastname: Gerondakis
authors.forename: Ulrich
authors.initials: U
authors.lastname: Siebenlist
mesh_terms: D000818:Animals; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D016328:NF-kappa B / Q000502:physiology*
chemical_list: D016328:NF-kappa B
references.citation: Cell Death Differ. 2006 May;13(5):826-33
references.pmid: 16439988
references.citation: Nat Immunol. 2009 Jun;10(6):647-54
references.pmid: 19412180
references.citation: J Immunol. 2008 Apr 1;180(7):4728-41
references.pmid: 18354197
references.citation: Oncogene. 2005 Feb 3;24(6):992-1000
references.pmid: 15592506
references.citation: Nat Rev Immunol. 2004 May;4(5):348-59
references.pmid: 15122200
references.citation: Gastroenterology. 2002 Jun;122(7):1853-68
references.pmid: 12055593
references.citation: J Exp Med. 2001 Mar 5;193(5):631-6
references.pmid: 11238593
references.citation: Annu Rev Immunol. 2005;23:487-513
references.pmid: 15771579
references.citation: Immunity. 2004 Jul;21(1):19-30
references.pmid: 15345217
references.citation: Immunity. 2009 Feb 20;30(2):180-92
references.pmid: 19239902
references.citation: J Immunol. 2009 Mar 15;182(6):3406-13
references.pmid: 19265118
references.citation: Annu Rev Immunol. 2008;26:627-50
references.pmid: 18370924
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20072-6
references.pmid: 19104040
references.citation: Eur J Immunol. 2009 Jan;39(1):78-84
references.pmid: 19130560
references.citation: Nature. 2000 Mar 23;404(6776):402-7
references.pmid: 10746729
references.citation: J Immunol. 2007 Nov 15;179(10):6799-807
references.pmid: 17982070
references.citation: Mol Cell Biol. 2005 Apr;25(8):3209-19
references.pmid: 15798206
references.citation: J Immunol. 2008 Jun 1;180(11):7240-8
references.pmid: 18490723
references.citation: Annu Rev Immunol. 2009;27:287-312
references.pmid: 19302042
references.citation: Nat Immunol. 2008 Dec;9(12):1379-87
references.pmid: 18978795
references.citation: Blood. 2009 May 7;113(19):4566-74
references.pmid: 19196865
references.citation: J Exp Med. 1998 Jan 19;187(2):147-59
references.pmid: 9432973
references.citation: Nat Rev Immunol. 2009 Jan;9(1):15-27
references.pmid: 19079135
references.citation: J Exp Med. 2004 Nov 1;200(9):1205-11
references.pmid: 15504821
references.citation: J Exp Med. 2000 Oct 16;192(8):1175-82
references.pmid: 11034607
references.citation: J Immunol. 2001 Nov 15;167(10):5628-35
references.pmid: 11698434
references.citation: J Immunol. 2008 Nov 1;181(9):6244-54
references.pmid: 18941215
references.citation: J Immunol. 2007 Jun 1;178(11):6777-88
references.pmid: 17513725
references.citation: J Exp Med. 2009 Jul 6;206(7):1505-13
references.pmid: 19564355
references.citation: Immunity. 2005 Oct;23(4):445-58
references.pmid: 16226509
references.citation: Nat Rev Immunol. 2008 Nov;8(11):837-48
references.pmid: 18927578
references.citation: Cell Immunol. 2004 Nov-Dec;232(1-2):9-20
references.pmid: 15922711
references.citation: J Immunol. 2001 Aug 15;167(4):1909-19
references.pmid: 11489970
references.citation: Curr Opin Immunol. 2008 Apr;20(2):158-61
references.pmid: 18456486
references.citation: Semin Immunol. 2008 Feb;20(1):14-25
references.pmid: 18261920
references.citation: J Immunol. 2006 Apr 1;176(7):3995-4002
references.pmid: 16547234
references.citation: Nat Rev Immunol. 2006 Oct;6(10):728-40
references.pmid: 16998507
references.citation: Semin Immunol. 2004 Dec;16(6):429-35
references.pmid: 15541657
references.citation: Trends Immunol. 2007 Apr;28(4):169-75
references.pmid: 17336158
references.citation: J Immunol. 2009 Aug 15;183(4):2205-12
references.pmid: 19661265
references.citation: Immunity. 2001 Sep;15(3):375-85
references.pmid: 11567628
references.citation: Annu Rev Immunol. 2002;20:709-60
references.pmid: 11861616
references.citation: Annu Rev Immunol. 2006;24:571-606
references.pmid: 16551260
references.citation: Semin Immunopathol. 2008 Dec;30(4):383-98
references.pmid: 18925397
references.citation: Int Immunol. 1999 Sep;11(9):1431-9
references.pmid: 10464164
references.citation: Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12634-8
references.pmid: 7809091
references.citation: Proc Natl Acad Sci U S A. 1990 Dec;87(24):10028-32
references.pmid: 2263603
references.citation: Nat Immunol. 2009 Jul;10(7):669-71
references.pmid: 19536187
references.citation: J Exp Med. 1998 Mar 2;187(5):663-74
references.pmid: 9480976
references.citation: Nature. 2001 Nov 22;414(6862):457-62
references.pmid: 11719808
references.citation: Nat Immunol. 2009 Jan;10(1):38-47
references.pmid: 19060899
references.citation: Eur J Immunol. 2006 Nov;36(11):3033-43
references.pmid: 17048267
references.citation: Cytokine Growth Factor Rev. 2000 Dec;11(4):303-20
references.pmid: 10959078
references.citation: PLoS Biol. 2009 Mar 3;7(3):e51
references.pmid: 19260764
references.citation: Nat Rev Immunol. 2005 Jun;5(6):435-45
references.pmid: 15905862
references.citation: Blood. 2005 Nov 15;106(10):3457-64
references.pmid: 16037393
references.citation: J Immunol. 2008 Apr 15;180(8):5384-92
references.pmid: 18390720
references.citation: Nat Immunol. 2006 Aug;7(8):851-8
references.pmid: 16799562
references.citation: J Immunol. 1998 May 1;160(9):4398-405
references.pmid: 9574544
references.citation: J Exp Med. 1995 Mar 1;181(3):1091-9
references.pmid: 7532676
references.citation: Immunol Res. 2008;42(1-3):106-17
references.pmid: 18818886
references.citation: J Exp Med. 1997 Jun 2;185(11):1897-907
references.pmid: 9166419
references.citation: Nat Immunol. 2005 Nov;6(11):1087-95
references.pmid: 16186825
references.citation: Nat Rev Immunol. 2008 May;8(5):362-71
references.pmid: 18379575
references.citation: Immunity. 2008 Sep 19;29(3):423-37
references.pmid: 18799149
references.citation: Immunity. 2003 Mar;18(3):331-42
references.pmid: 12648451
references.citation: J Exp Med. 1995 Jan 1;181(1):181-92
references.pmid: 7807002
references.citation: Cell Death Differ. 2006 May;13(5):697-701
references.pmid: 16528380
references.citation: Trends Immunol. 2002 Jan;23(1):31-9
references.pmid: 11801452
references.citation: J Biol Chem. 2007 Jun 15;282(24):17475-85
references.pmid: 17446175
references.citation: Nature. 2008 Jul 10;454(7201):226-31
references.pmid: 18568025
references.citation: J Infect Chemother. 2008 Aug;14(4):265-9
references.pmid: 18709529
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10883-8
references.pmid: 18663224
references.citation: J Immunol. 2004 Mar 15;172(6):3704-11
references.pmid: 15004174
references.citation: Adv Exp Med Biol. 2007;596:149-54
references.pmid: 17338183
references.citation: Oncogene. 2006 Oct 30;25(51):6781-99
references.pmid: 17072328
references.citation: Adv Immunol. 2007;94:157-214
references.pmid: 17560275
references.citation: PLoS One. 2009;4(3):e4736
references.pmid: 19270748
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3274-9
references.pmid: 16484370
references.citation: Med Immunol. 2004 Mar 29;3(1):1
references.pmid: 15050028
references.citation: Immunol Cell Biol. 2007 Aug-Sep;85(6):471-5
references.pmid: 17637697
references.citation: J Exp Med. 2001 Oct 15;194(8):1021-32
references.pmid: 11602633
references.citation: Blood. 2003 Nov 1;102(9):3270-9
references.pmid: 12855571
references.citation: J Immunol. 2007 Jul 1;179(1):179-85
references.pmid: 17579036
references.citation: J Exp Med. 2001 Dec 17;194(12):1861-74
references.pmid: 11748286
references.citation: J Exp Med. 1998 Jan 19;187(2):185-96
references.pmid: 9432976
references.citation: Oncogene. 2006 Oct 30;25(51):6758-80
references.pmid: 17072327
references.citation: Immunity. 2002 Feb;16(2):257-70
references.pmid: 11869686
references.citation: Science. 2001 Aug 24;293(5534):1495-9
references.pmid: 11520989
references.citation: Mol Cell. 2000 Jun;5(6):981-92
references.pmid: 10911992
references.citation: Nature. 2008 Dec 11;456(7223):819-23
references.pmid: 18849970
references.citation: Curr Opin Immunol. 1998 Jun;10(3):353-9
references.pmid: 9638373
references.citation: Cell Growth Differ. 1994 Dec;5(12):1321-31
references.pmid: 7696180
references.citation: Eur J Immunol. 2007 Nov;37 Suppl 1:S46-52
references.pmid: 17972344
references.citation: Immunity. 2006 Jun;24(6):729-739
references.pmid: 16782029
references.citation: Science. 1997 Jan 24;275(5299):540-3
references.pmid: 8999800
references.citation: J Immunol. 2004 Aug 1;173(3):1612-9
references.pmid: 15265889
references.citation: J Immunol. 2009 Sep 1;183(5):2974-83
references.pmid: 19648281
references.citation: Mol Cell. 2003 Mar;11(3):685-94
references.pmid: 12667451
references.citation: Immunol Rev. 2007 Feb;215:123-35
references.pmid: 17291284
references.citation: Nat Immunol. 2001 Jan;2(1):45-50
references.pmid: 11135577
references.citation: Annu Rev Immunol. 2009;27:693-733
references.pmid: 19302050
references.citation: J Immunol. 2009 Jun 15;182(12):7729-37
references.pmid: 19494297
references.citation: J Exp Med. 2005 Feb 21;201(4):603-14
references.pmid: 15728238
references.citation: Immunity. 2007 Sep;27(3):438-52
references.pmid: 17869136
references.citation: J Immunol. 2001 Sep 15;167(6):3257-65
references.pmid: 11544313
references.citation: J Exp Med. 2003 Jun 16;197(12):1613-21
references.pmid: 12810684
references.citation: J Immunol. 2007 Dec 1;179(11):7514-22
references.pmid: 18025196
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9160-5
references.pmid: 16751279
references.citation: J Immunol. 1996 Aug 1;157(3):1149-55
references.pmid: 8757620
references.citation: Genes Dev. 1999 Feb 15;13(4):400-11
references.pmid: 10049356
references.citation: Ann N Y Acad Sci. 2004 Dec;1029:101-14
references.pmid: 15681750
references.citation: Immunol Rev. 2003 Oct;195:91-105
references.pmid: 12969313
references.citation: Cell Mol Life Sci. 2008 Apr;65(7-8):1123-32
references.pmid: 18193168
references.citation: J Immunol. 2007 Jul 1;179(1):195-200
references.pmid: 17579038
references.citation: Int Immunol. 2002 Sep;14(9):983-91
references.pmid: 12202396
references.citation: Immunol Rev. 2000 Aug;176:116-33
references.pmid: 11043772
references.citation: J Immunol. 2009 Jun 1;182(11):6736-43
references.pmid: 19454668
references.citation: Curr Opin Immunol. 2007 Apr;19(2):176-85
references.pmid: 17306520
references.citation: Immunity. 2003 Sep;19(3):377-89
references.pmid: 14499113
references.citation: Curr Opin Immunol. 2008 Apr;20(2):178-84
references.pmid: 18403191
references.citation: Nat Immunol. 2005 Feb;6(2):198-203
references.pmid: 15619624
references.citation: J Immunol. 2001 Nov 1;167(9):4948-56
references.pmid: 11673501
references.citation: J Exp Med. 2003 Jun 16;197(12):1623-33
references.pmid: 12810685
references.citation: Int Immunol. 2006 Oct;18(10):1405-11
references.pmid: 16940043
references.citation: Immunity. 2008 Oct 17;29(4):523-37
references.pmid: 18957265
references.citation: J Exp Med. 2004 Nov 1;200(9):1099-102
references.pmid: 15520242
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11677-82
references.pmid: 16857737
references.citation: Nat Immunol. 2007 Sep;8(9):903-5
references.pmid: 17712339
references.citation: Genes Dev. 1997 Dec 15;11(24):3482-96
references.pmid: 9407039
references.citation: Cell Res. 2009 Feb;19(2):196-207
references.pmid: 18781138
references.citation: J Exp Med. 1997 Mar 3;185(5):953-61
references.pmid: 9120401
references.citation: Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9136-41
references.pmid: 10430908
references.citation: J Exp Med. 1999 Jan 4;189(1):145-58
references.pmid: 9874571
references.citation: Mol Cell. 2000 Jun;5(6):969-79
references.pmid: 10911991
references.citation: J Immunol. 2007 Nov 15;179(10):6596-603
references.pmid: 17982049
references.citation: J Immunol. 1999 Dec 15;163(12):6581-8
references.pmid: 10586052
references.citation: Immunology. 2005 May;115(1):1-20
references.pmid: 15819693
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5757-9
references.pmid: 11983876
references.citation: Eur J Immunol. 2008 Dec;38(12):3508-19
references.pmid: 19003818
references.citation: J Biol Chem. 2007 May 25;282(21):15884-93
references.pmid: 17392286
references.citation: Nature. 1999 Jan 28;397(6717):363-8
references.pmid: 9950430
references.citation: J Exp Med. 2004 Mar 1;199(5):617-27
references.pmid: 14993249
references.citation: Immunity. 2007 Jun;26(6):703-14
references.pmid: 17582343
references.citation: BMC Immunol. 2005 Apr 18;6:8
references.pmid: 15836790
references.citation: J Immunol. 2002 Apr 15;168(8):3721-31
references.pmid: 11937522
references.citation: Eur J Immunol. 2006 Dec;36(12):3315-23
references.pmid: 17109470
references.citation: Cell. 1995 Jan 27;80(2):331-40
references.pmid: 7834753
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4514-9
references.pmid: 11930006
references.citation: Int Immunol. 2006 May;18(5):653-9
references.pmid: 16571606
references.citation: Curr Top Microbiol Immunol. 2007;314:195-212
references.pmid: 17593662
references.citation: PLoS One. 2009;4(5):e5456
references.pmid: 19421318
references.citation: J Immunol. 2008 Oct 15;181(8):5405-13
references.pmid: 18832697
references.citation: Immunol Rev. 2008 Aug;224:284-94
references.pmid: 18759934
references.citation: Curr Opin Genet Dev. 2000 Oct;10(5):529-35
references.pmid: 10980431
references.citation: J Biol Chem. 2003 Apr 4;278(14):12006-12
references.pmid: 12556537
references.citation: Oncogene. 2004 Mar 25;23(13):2275-86
references.pmid: 14755244
references.citation: J Immunol. 2003 Apr 1;170(7):3724-31
references.pmid: 12646638
references.citation: J Immunol. 2008 Jul 1;181(1):400-7
references.pmid: 18566406
references.citation: Immunity. 2000 Nov;13(5):677-89
references.pmid: 11114380
references.citation: Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):369-78
references.pmid: 12220550
references.citation: J Immunol. 2004 Aug 15;173(4):2245-52
references.pmid: 15294936
references.citation: Mol Immunol. 2002 Mar;38(11):849-59
references.pmid: 11922943
references.citation: Nat Immunol. 2002 Oct;3(10):958-65
references.pmid: 12352969
references.citation: Genes Dev. 1995 Aug 15;9(16):1965-77
references.pmid: 7649478
references.citation: J Immunol. 2007 Mar 1;178(5):2932-9
references.pmid: 17312138
references.citation: Cell. 2007 Jan 26;128(2):369-81
references.pmid: 17254973
references.citation: Immunity. 2002 Dec;17(6):823-33
references.pmid: 12479827
references.citation: Immunol Rev. 2006 Feb;209:159-69
references.pmid: 16448541
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12435-8
references.pmid: 18713867
references.citation: Cell Immunol. 2006 Feb;239(2):92-102
references.pmid: 16797504
references.citation: J Exp Med. 2002 Sep 16;196(6):743-52
references.pmid: 12235208
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4566-71
references.pmid: 15070758
references.citation: Blood. 2007 Mar 15;109(6):2521-8
references.pmid: 17105816
references.citation: J Clin Invest. 2006 Nov;116(11):2964-71
references.pmid: 17039258
references.citation: J Exp Med. 2001 Feb 19;193(4):417-26
references.pmid: 11181694
references.citation: Blood. 2008 Dec 15;112(13):5063-73
references.pmid: 18805964
references.citation: Cell. 1995 Jan 27;80(2):321-30
references.pmid: 7834752
references.citation: Adv Exp Med Biol. 2007;597:72-9
references.pmid: 17633018
references.citation: Immunol Lett. 2007 Mar 15;109(1):36-46
references.pmid: 17275920
references.citation: Genes Dev. 2009 Jun 1;23(11):1270-82
references.pmid: 19487568
references.citation: Nat Immunol. 2006 Apr;7(4):344-53
references.pmid: 16550197
references.citation: Immunol Rev. 2007 Feb;215:15-31
references.pmid: 17291276
references.citation: EMBO J. 1996 Dec 16;15(24):7099-107
references.pmid: 9003785
references.citation: EMBO J. 2003 Jan 2;22(1):121-30
references.pmid: 12505990
references.citation: J Immunol. 2004 Apr 15;172(8):4667-71
references.pmid: 15067039
references.citation: J Exp Med. 1995 Mar 1;181(3):1169-77
references.pmid: 7869034
references.citation: Immunity. 2005 Apr;22(4):519-31
references.pmid: 15845455
references.citation: Curr Opin Immunol. 2009 Apr;21(2):140-5
references.pmid: 19321327
references.citation: J Immunol. 2005 Sep 15;175(6):3790-9
references.pmid: 16148125
references.citation: J Exp Med. 2000 Apr 17;191(8):1281-92
references.pmid: 10770796
references.citation: Curr Opin Immunol. 2003 Jun;15(3):354-61
references.pmid: 12787764
references.citation: Blood. 2007 Oct 1;110(7):2381-9
references.pmid: 17620454
references.citation: Nat Immunol. 2009 Apr;10(4):427-36
references.pmid: 19270712
references.citation: Immunol Res. 2008;42(1-3):210-8
references.pmid: 19002607
references.citation: Cell Mol Life Sci. 2004 Feb;61(3):263-80
references.pmid: 14770292
references.citation: J Exp Med. 2003 Apr 7;197(7):861-74
references.pmid: 12668645
references.citation: J Immunol. 2000 Jul 15;165(2):804-12
references.pmid: 10878354
references.citation: Genes Dev. 2000 Mar 15;14(6):690-703
references.pmid: 10733529
references.citation: Oncogene. 2003 Nov 20;22(52):8472-86
references.pmid: 14627988
references.citation: Adv Immunol. 2008;99:59-94
references.pmid: 19117532
references.citation: Immunity. 1997 Apr;6(4):479-90
references.pmid: 9133427
references.citation: Ann N Y Acad Sci. 2008 Nov;1143:105-22
references.pmid: 19076347
references.citation: Cell Growth Differ. 1990 Aug;1(8):345-50
references.pmid: 2278886
references.citation: Cell Cycle. 2007 Sep 15;6(18):2236-40
references.pmid: 17881896
references.citation: Nat Immunol. 2007 Sep;8(9):984-91
references.pmid: 17660823
references.citation: Mol Immunol. 2005 Feb;42(4):413-7
references.pmid: 15607792
references.citation: Int Immunol. 2009 Apr;21(4):467-76
references.pmid: 19251935
references.citation: Clin Exp Immunol. 2009 Jul;157(1):20-6
references.pmid: 19659766
references.citation: Semin Immunol. 2003 Jun;15(3):159-66
references.pmid: 14563114
references.citation: Mol Cell. 2002 Dec;10(6):1283-94
references.pmid: 12504005
references.citation: J Immunol. 2004 Feb 15;172(4):2067-75
references.pmid: 14764671
references.citation: Arthritis Res Ther. 2008;10(4):212
references.pmid: 18771589
references.citation: J Immunol. 2008 Oct 1;181(7):4696-708
references.pmid: 18802072
references.citation: Nat Rev Immunol. 2009 Jul;9(7):491-502
references.pmid: 19521398
references.citation: J Immunol. 2004 Feb 15;172(4):2265-73
references.pmid: 14764695
references.citation: Cell. 2008 Feb 8;132(3):344-62
references.pmid: 18267068
references.citation: Immunity. 2008 Sep 19;29(3):438-50
references.pmid: 18799150
references.citation: J Exp Med. 2009 Aug 3;206(8):1803-16
references.pmid: 19581408
references.citation: J Immunol. 2007 Jan 15;178(2):953-60
references.pmid: 17202357
references.citation: Int Immunol. 2005 Jun;17(6):815-25
references.pmid: 15908447
references.citation: Immunity. 2001 Mar;14(3):217-30
references.pmid: 11290332
references.citation: Curr Opin Immunol. 2008 Apr;20(2):149-57
references.pmid: 18434123
references.citation: EMBO J. 2000 Dec 1;19(23):6351-60
references.pmid: 11101508
references.citation: Int Immunol. 2000 Aug;12(8):1167-72
references.pmid: 10917891
references.citation: J Exp Med. 2008 Nov 24;205(12):2827-38
references.pmid: 19015306
references.citation: Curr Opin Immunol. 2005 Jun;17(3):244-50
references.pmid: 15886113
references.citation: Immunity. 2008 Sep 19;29(3):451-63
references.pmid: 18799151
references.citation: J Immunol. 2000 Nov 1;165(9):5004-10
references.pmid: 11046028
references.citation: BMB Rep. 2009 Apr 30;42(4):189-93
references.pmid: 19403040