[Acute hepatitis of unspecified etiology: etiological structure and clinical-laboratory characteristics].
The straight line nucleic acids detection method of viruses and wide spectrum of virus antigens immunodiagnostics in acute hepatitis of unknown etiology patients has allowed verifying the diagnosis at 19% cases (a viral hepatitis A, C or E). Results of research do not allow to consider hepatotropic viruses HGV, TTV, PV B19, EBV, CMV, HHV 1, 2, 6 and 8 type, NV-F as etiological agents at the majority of patients of investigated group, and the data of the anamnesis and a clinical and laboratory picture of a current of disease does not allow to exclude at 29.4% of patients a drug-induced hepatitis. Despite detailed molecular-biological and immunological inspection of patients, at 37.9% of acute hepatitis of unknown etiology patients it was not possible to establish a connection with hepatitis and defined etiological factor (the infectious agent).
Iushchuk
N D
ND
Tsyganova
E V
EV
Znoĭko
O O
OO
Karetkina
G N
GN
Solonin
S A
SA
Mikhaĭlov
M I
MI
Isaguliants
M G
MG
Petrova
T V
TV
Kashirin
V I
VI
Cheshik
D S
DS
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D006518:Hepatitis Viruses / Q000235:genetics / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D055815:Young Adult