title: Association study between an outbreak of Guillain-Barre syndrome in Jilin, China, and preceding Campylobacter jejuni infection.
abstract: From June to July 2007, 36 cases of Guillain-Barre syndrome (GBS) occurred in a township in north China. Serological study and bacteria culture were performed to investigate the association between preceding Campylobacter jejuni infection and this GBS outbreak. Anti-C. jejuni antibodies were found in significantly higher numbers of GBS patients (IgM 84%, IgG 87.5%) than in healthy inspection cases (IgM 33%, IgG 27%). IgG anti-GM1 was the dominant anti-ganglioside antibody among the GBS patients. Seven C. jejuni isolates (four from human stool and three from poultry specimens taken from the patients' houses) were obtained. Serotyping and molecular analysis were used to investigate the genetic relatedness among these C. jejuni isolates. The four human isolates, collected from residents of the same district, were indistinguishable by both pulsed-field gel electrophoresis and multilocus sequence typing, suggesting these patients had a common source of infection. A new sequence type, sequence type-2993, was assigned to the human C. jejuni isolates, three of which belonged to Penner serotype heat-stable (HS):41. Both serotype and molecular subtype of the human C. jejuni isolates were different from those of isolates obtained from poultry specimens. Our results suggest that the antecedent C. jejuni infection triggered this GBS outbreak in China.
authors.affiliation: Department of Diagnosis, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Maojun
authors.initials: M
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.forename: Lihua
authors.initials: L
authors.lastname: He
authors.forename: Fanliang
authors.initials: F
authors.lastname: Meng
authors.forename: Yixin
authors.initials: Y
authors.lastname: Gu
authors.forename: Minghuan
authors.initials: M
authors.lastname: Zheng
authors.forename: Yunwei
authors.initials: Y
authors.lastname: Gong
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Ruan
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Collette
authors.initials: C
authors.lastname: Fitzgerald
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D002169:Campylobacter Infections / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D016123:Campylobacter jejuni / Q000145:classification* / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification*; D002645:Chickens / Q000382:microbiology; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005243:Feces / Q000382:microbiology; D005260:Female; D005516:Food Microbiology; D005677:G(M1) Ganglioside / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000145:classification / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008460:Meat / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D012703:Serotyping; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside