A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.
We present a novel computational model for maladaptive cardiac growth in which kinematic changes of the cardiac chambers are attributed to alterations in cytoskeletal architecture and in cellular morphology. We adopt the concept of finite volume growth characterized through the multiplicative decomposition of the deformation gradient into an elastic part and a growth part. The functional form of its growth tensor is correlated to sarcomerogenesis, the creation and deposition of new sarcomere units. In response to chronic volume-overload, an increased diastolic wall strain leads to the addition of sarcomeres in series, resulting in a relative increase in cardiomyocyte length, associated with eccentric hypertrophy and ventricular dilation. In response to chronic pressure-overload, an increased systolic wall stress leads to the addition of sacromeres in parallel, resulting in a relative increase in myocyte cross sectional area, associated with concentric hypertrophy and ventricular wall thickening. The continuum equations for both forms of maladaptive growth are discretized in space using a nonlinear finite element approach, and discretized in time using the implicit Euler backward scheme. We explore a generic bi-ventricular heart model in response to volume- and pressure-overload to demonstrate how local changes in cellular morphology translate into global alterations in cardiac form and function.
Göktepe
Serdar
S
Department of Mechanical Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA. goktepe@stanford.edu
Abilez
Oscar John
OJ
Parker
Kevin Kit
KK
Kuhl
Ellen
E
D001696:Biomechanical Phenomena; D001794:Blood Pressure; D006332:Cardiomegaly / Q000503:physiopathology*; D003599:Cytoskeleton / Q000648:ultrastructure; D020342:Finite Element Analysis; D006321:Heart / Q000254:growth & development*; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D012518:Sarcomeres / Q000502:physiology*; D013314:Stress, Mechanical