The importance of cognitive aging for understanding dementia.
A third of those over 80 years of age are likely to have dementia, the lack of a cure requires efforts directed at prevention and delaying the age of onset. We argue here for the importance of understanding the cognitive ageing process, seen as the decline in various cognitive functions from adulthood to old age. The impact of age on cognitive function is heterogeneous and the identification of risk factors associated with adverse cognitive ageing profiles would allow well-targeted interventions, behavioural or pharmacological, to delay and reduce the population burden of dementia. A shift away from binary outcomes such as dementia assessed at one point in time in elderly populations to research on cognitive ageing using repeated measures of cognitive function and starting earlier in the life course would allow the sources of variability in ageing to be better understood.
Singh-Manoux
Archana
A
INSERM, U1018 Centre for Research in Epidemiology & Population Health Hôpital Paul Brousse, Bâtiment 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France. Archana.Singh-Manoux@inserm.fr
Kivimäki
Mika
M
D000375:Aging; D000544:Alzheimer Disease / Q000453:epidemiology / Q000503:physiopathology; D003071:Cognition; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D005602:France / Q000453:epidemiology; D006801:Humans; D015995:Prevalence; D012307:Risk Factors; D014944:World Health Organization
JAMA. 1994 Apr 6;271(13):1004-10
8139057
N Engl J Med. 2005 Jan 20;352(3):245-53
15659724
Neurology. 2005 Jan 25;64(2):277-81
15668425
Lancet. 2002 Nov 30;360(9347):1759-66
12480441
Psychol Aging. 2001 Mar;16(1):3-11
11302365
J Gerontol A Biol Sci Med Sci. 1997 Mar;52(2):M117-25
9060980
Lancet Neurol. 2006 Aug;5(8):713-20
16857578
Int J Epidemiol. 1985 Mar;14(1):32-8
3872850
Lancet. 2006 Jul 29;368(9533):387-403
16876668
JAMA. 2008 Apr 16;299(15):1763
18413868
Arch Neurol. 2001 Mar;58(3):397-405
11255443
Science. 2002 Jul 19;297(5580):353-6
12130773
Nat Rev Neurosci. 2007 Mar;8(3):233-9
17299455
Neurology. 2003 Jun 24;60(12):1909-15
12821732
J Neuropathol Exp Neurol. 2009 Jan;68(1):1-14
19104448
Neurology. 1988 Nov;38(11):1682-7
3185902
Neuropsychologia. 2009 Aug;47(10):2015-28
19467352
Arch Neurol. 2000 Jun;57(6):808-13
10867777
Annu Rev Neurosci. 2003;26:81-104
12574495