title: Predictors of menstrual resumption by patients with anorexia nervosa.
abstract: OBJECTIVE
  To investigate which factors predict the resumption of menstruation by patients with anorexia nervosa (AN).
  
  
  METHODS
  Participants were AN patients who, even after weight recovery by inpatient treatment, had prolonged amenorrhea (N=11), AN patients who resumed menstruation after weight recovery (N=9), and age-matched healthy controls (N=12). Anthropometric data and the serum levels of leptin, insulin-like growth factor I (IGF-1), cortisol, luteinizing hormone (LH), estradiol (E2), and other hormones were measured at the beginning of the inpatient treatment and after weight recovery.
  
  
  RESULTS
  Of the baseline anthropometric and hormonal factors, logistic regression analysis extracted a high serum cortisol level as a predictor of the inhibition of the resumption of menstruation. After weight recovery, the E2 and leptin levels were significantly higher for eumenorrheic patients than for amenorrheic patients.
  
  
  CONCLUSIONS
  The baseline serum cortisol level was a predictor of the prolonged inhibition of menstrual recovery.
authors.affiliation: Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan. chikakok@d2.dion.ne.jp
authors.forename: C
authors.initials: C
authors.lastname: Arimura
authors.forename: T
authors.initials: T
authors.lastname: Nozaki
authors.forename: S
authors.initials: S
authors.lastname: Takakura
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Takii
authors.forename: N
authors.initials: N
authors.lastname: Sudo
authors.forename: C
authors.initials: C
authors.lastname: Kubo
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D000704:Analysis of Variance; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D020738:Leptin; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D006854:Hydrocortisone
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