title: Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis.
abstract: OBJECTIVE
  Types 1 and 2 by Delahunt of papillary renal cell carcinoma (PRCC) are traditionally differentiated. An oncocytic variant of PRCC (O-PRCC) has recently been described. We compare clinical data of O-PRCC with other subtypes of PRCC such as the main tumour size, necrotic changes, presence of pseudocapsula and real extrarenal growth in retrospective study.
  
  
  METHODS
  From 1/1992 to 10/2009, 1,398 patients with 1,436 renal tumours were surgically treated in our institution. PRCCs were described in 109 (7.6%). Among PRCC, O-PRCCs were in 12 (11%), PRCC type 1 in 86 (78.9%), PRCC type 2 in 8 (7.3%) and others in 3 (2.8%) cases.
  
  
  RESULTS
  The patient's mean age with O-PRCC (M:F ratio = 2:1) was 67.5 +/- 10.9 versus 63.5 +/- 14.1 in type 1 and 57.9 +/- 5.7 in type 2, the mean tumour size was 35 +/- 12 mm versus 47 +/- 22 and 37 +/- 17, respectively. The follow-up of O-PRCC is 35.3 +/- 12.3 months and all cases are without recurrence. We did not find any pseudocapsula in O-PRCC but it was a major sign of PRCC type 1 (32.6%). Huge microscopic necrotic changes were described in 33.3% of O-PRCC, in 33.7% of PRCC type 1 and 62.5% of PRCC type 2. Extrarenal growth was found only in 16.7% O-PRCC versus 40.7% in PRCC type I.
  
  
  CONCLUSIONS
  None of the O-PRCC had pseudocapsula and none had massive necroses in comparison of O-PRCC with PRCC types I and II. Extrarenal growth in O-PRCC is relatively rare. The malignant potential of O-PRCC is low.
authors.affiliation: Department of Urology, Faculty of Medicine in Pilsen, Charles University in Prague and Faculty Hospital, Dr. E. Benese 13, 30599, Plzen, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Urge
authors.forename: O
authors.initials: O
authors.lastname: Hes
authors.forename: J
authors.initials: J
authors.lastname: Ferda
authors.forename: Z
authors.initials: Z
authors.lastname: Chudácek
authors.forename: V
authors.initials: V
authors.lastname: Eret
authors.forename: M
authors.initials: M
authors.lastname: Michal
authors.forename: M
authors.initials: M
authors.lastname: Brunelli
authors.forename: G
authors.initials: G
authors.lastname: Martignoni
authors.forename: M
authors.initials: M
authors.lastname: Hora
mesh_terms: D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D000368:Aged; D001706:Biopsy; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009392:Nephrectomy; D014057:Tomography, X-Ray Computed
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