Maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models.
BACKGROUND
Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution.


OBJECTIVE
We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted geostatistical (TAG) model with a finer spatial resolution, for use in pregnancy studies.


METHODS
The AQMS and TAG exposure models were implemented in two areas surrounding medium-size cities in which 776 pregnant women were followed as part of the EDEN mother-child cohort. The exposure models were compared in terms of estimated nitrogen dioxide (NO2) levels and of their association with birth weight.


RESULTS
The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively. Exposure patterns displayed greater spatial than temporal variations. Exposure during the first trimester of pregnancy was most strongly associated with birth weight for women living < 2 km away from an AQMS: a 10-µg/m3 increase in NO2 exposure was associated with an adjusted difference in birth weight of -37 g [95% confidence interval (CI), -75 to 1 g] for the nearest-AQMS model and of -51 g (95% CI, -128 to 26 g) for the TAG model. The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS.


CONCLUSIONS
The two exposure models tended to give consistent results in terms of association with birth weight, despite the moderate concordance between exposure estimates.
Lepeule
Johanna
J
INSERM, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Institut Albert Bonniot, Grenoble, France. johanna.lepeule@ujf-grenoble.fr
Caïni
Fabrice
F
Bottagisi
Sébastien
S
Galineau
Julien
J
Hulin
Agnès
A
Marquis
Nathalie
N
Bohet
Aline
A
Siroux
Valérie
V
Kaminski
Monique
M
Charles
Marie-Aline
MA
Slama
Rémy
R
D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005602:France; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure; D008962:Models, Theoretical; D009585:Nitrogen Dioxide / Q000633:toxicity*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D009585:Nitrogen Dioxide
Lancet. 1986 Feb 8;1(8476):307-10
2868172
Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):182-90
18226073
Environ Health Perspect. 2007 Sep;115(9):1283-92
17805417
Occup Environ Med. 2005 Aug;62(8):524-30
16046604
J Epidemiol Community Health. 2004 Jan;58(1):11-7
14684720
Environ Health Perspect. 2005 Nov;113(11):1638-44
16263524
Occup Environ Med. 2008 Sep;65(9):579-86
18070798
Hum Reprod. 2003 Mar;18(3):638-43
12615838
J Expo Sci Environ Epidemiol. 2007 Aug;17(5):426-32
16736056
Environ Res. 2005 Jan;97(1):32-42
15476731
Environ Health Perspect. 2007 Jul;115(7):1118-24
17637932
Environ Health Perspect. 2006 Nov;114(11):1636-42
17107846
Environ Health Perspect. 2008 Jun;116(6):791-8
18560536
Environ Health Perspect. 2009 Aug;117(8):1313-21
19672414
Environ Health Perspect. 2000 May;108(5):419-26
10811568
Environ Health Perspect. 2008 May;116(5):680-6
18470315
Environ Health Perspect. 2005 Sep;113(9):1212-21
16140630
Environ Sci Technol. 2008 Feb 15;42(4):1337-44
18351114
J Expo Anal Environ Epidemiol. 2004 Sep;14(5):391-6
15361898
Br J Nutr. 2009 Feb;101(4):583-91
18631416
Environ Health Perspect. 2003 Feb;111(2):207-16
12573907
Pediatrics. 2005 Jan;115(1):121-8
15629991
Environ Health Perspect. 2008 Mar;116(3):362-9
18335104
Int J Epidemiol. 2008 Apr;37(2):382-5
18184671
Environ Health Perspect. 2009 Oct;117(10):1526-30
20019901
N Engl J Med. 2007 Feb 1;356(5):447-58
17267905
Epidemiology. 2001 Nov;12(6):643-8
11679791
Epidemiology. 2005 May;16(3):385-95
15824556
Am Ind Hyg Assoc J. 1976 Oct;37(10):570-7
983946