Excavatoids L-N, new 12-hydroxybriaranes from the cultured octocoral Briareum excavatum (Briareidae).
Three new 12-hydroxybriarane diterpenoids, excavatoids L-N (1-3), have been isolated from the cultured octocoral Briareum excavatum. The structures of new briaranes 1-3 were elucidated by the interpretations of spectroscopic methods. Excavatoid L (1) displayed moderate inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
Su
Jui-Hsin
JH
National Museum of Marine Biology & Aquarium (NMMBA), Checheng, Pingtung 944, Taiwan.
Chen
Bo-Yuan
BY
Hwang
Tsong-Long
TL
Chen
Yung-Husan
YH
Huang
I-Chu
IC
Lin
Mei-Ru
MR
Chen
Jih-Jung
JJ
Fang
Lee-Shing
LS
Wang
Wei-Hsien
WH
Li
Jan-Jung
JJ
Sheu
Jyh-Horng
JH
Sung
Ping-Jyun
PJ
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects*; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism
D001688:Biological Products; D004224:Diterpenes; C551755:excavatoid L; C551756:excavatoid M; C551757:excavatoid N; D013481:Superoxides; D010196:Pancreatic Elastase