Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry.
Optical coherence tomography (OCT) and scanning laser polarimetry (GDx ECC) are non-invasive methods used to assess retinal nerve fiber layer (RNFL) thickness, which may be a reliable tool used to monitor axonal loss in multiple sclerosis (MS). The objectives of this study are (1) to compare OCT with the GDx ECC; (2) to assess and compare the RNFL thickness in subgroups of MS. Ophthalmologic examination and RNFL assessment by OCT and GDx were performed in 65 MS patients (26 relapsing-remitting (RRMS), ten secondary-progressive (SPMS), 29 primary-progressive (PPMS)). Twenty-eight patients (43%) had a history of optic neuritis (ON). Adjustments were made for age and disease duration. RNFL thickness was reduced in eyes with previous ON (p < 0.01). No differences were found between PPMS and relapse-onset MS. OCT and GDx ECC measurements were moderately correlated (rho = 0.73, p < 0.01). Visual field-mean deviation (MD) values correlated with OCT means (r = 0.44, p < 0.01) and GDx ECC TSNIT average (r = 0.41, p < 0.01). In patients without previous ON, EDSS correlated with MD (r = -0.36, p < 0.01), visual field-pattern standard deviation (PSD) (r = 0.30, p < 0.05), OCT means (r = -0.31-0.30, p < 0.05) and macular volume (r = -0.37, p < 0.01). For MSIS-29 physical impact score, significant correlations were found with MD (r = -0.48, p < 0.01) and PSD (r = 0.48, p < 0.01).


CONCLUSIONS
No differences between PPMS and relapse-onset MS subgroups were found. RNFL thickness was reduced in eyes with previous ON. Although OCT and GDx ECC findings were moderately correlated and showed significant correlations with measures of visual function in patients without previous ON, EDSS correlated significantly with visual and OCT measures, but not with GDx ECC.
Siepman
Theodora A M
TA
Department of Neurology, MS Centre ErasMS, Erasmus MC, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
Bettink-Remeijer
Marijke Wefers
MW
Hintzen
Rogier Q
RQ
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D009412:Nerve Fibers / Q000473:pathology*; D009902:Optic Neuritis / Q000209:etiology / Q000473:pathology; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D057109:Scanning Laser Polarimetry; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology
Curr Opin Ophthalmol. 2008 Mar;19(2):136-40
18301287
Mult Scler. 2008 Jun;14(5):609-14
18424482
Ann Neurol. 2006 Apr;59(4):597-605
16566022
Mult Scler. 2008 Aug;14(7):906-12
18573835
Invest Ophthalmol Vis Sci. 2004 Mar;45(3):840-5
14985299
Brain. 2008 Jan;131(Pt 1):277-87
18056739
Ophthalmology. 2006 Feb;113(2):324-32
16406539
Eur J Ophthalmol. 2010 Jan-Feb;20(1):167-73
19882541
Ophthalmologica. 2007;221(3):186-9
17440281
J Neurol. 2010 Jul;257(7):1083-91
20143110
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3870-7
16936099
J Neurol Sci. 2009 Jul 15;282(1-2):96-105
19439327
Br J Ophthalmol. 2006 Jun;90(6):749-53
16481378
Acta Ophthalmol. 2010 Nov;88(7):748-52
19489763
Ann Neurol. 2005 Dec;58(6):840-6
16283615
Mult Scler. 2008 Aug;14(7):893-905
18573837
J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):505-9
9576544
Ann Neurol. 2005 Sep;58(3):383-91
16075460
Eye (Lond). 2009 Feb;23(2):407-12
17992198
Br J Ophthalmol. 2003 Jan;87(1):32-7
12488259
Lancet. 2008 Oct 25;372(9648):1502-17
18970977
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2889-95
16799030
N Engl J Med. 2000 Nov 16;343(20):1430-8
11078767
Neurology. 2003 Nov 25;61(10):1367-73
14638957
Neurology. 2007 Oct 16;69(16):1603-9
17938370
J Neurol. 2002 Aug;249(8):1072-7
12195457
Brain. 2001 May;124(Pt 5):962-73
11335698
Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2520-7
10509645
Eye (Lond). 2009 Jan;23(1):171-5
17721504
J Neurol. 2008 Oct;255(10):1555-60
18825432
J Neurol Sci. 2008 May 15;268(1-2):12-7
18054962
Neurology. 2005 Apr 12;64(7):1144-51
15824338
Lancet Neurol. 2007 Oct;6(10):903-12
17884680
Arch Ophthalmol. 1990 Apr;108(4):557-60
2322159
Arch Neurol. 2008 Jul;65(7):924-8
18625859
Neurology. 2007 Nov 27;69(22):2085-92
18040015
J Neurol. 2007 Nov;254(11):1595-6
17987252
Neurology. 2007 May 1;68(18):1488-94
17470751
Nat Clin Pract Neurol. 2008 Dec;4(12):664-75
19043423
Ann Neurol. 2006 Jun;59(6):963-9
16718705