title: Beyond alphabeta/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate.
abstract: Signaling by the gammadelta T cell receptor (TCR) is required not only for alphabeta/gammadelta lineage commitment but also to activate and elicit effector functions in mature gammadelta T cells. Notably, at both of these stages, the signal delivered by the gammadeltaTCR is more robust than the one delivered by either the preTCR or the alphabetaTCR. Recent studies now provide evidence that signaling by the gammadeltaTCR is also required at other stages during gammadelta T cell development. Remarkably, the strength of the gammadeltaTCR signal also plays a role at these other stages, as evidenced by the findings that genetic manipulation of gammadeltaTCR signal strength affects gammadelta T cell maturation and effector fate. In this review, we discuss how a strong TCR signal is a recurring theme in gammadelta T cell development and activation.
authors.affiliation: Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. hayessa@upstate.edu
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Hayes
authors.forename: Renee M
authors.initials: RM
authors.lastname: Laird
authors.forename: Paul E
authors.initials: PE
authors.lastname: Love
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology* / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta
references.citation: Nat Rev Immunol. 2003 Mar;3(3):233-42
references.pmid: 12658271
references.citation: J Exp Med. 1998 Feb 2;187(3):357-65
references.pmid: 9449716
references.citation: J Immunol. 1988 Jun 15;140(12):4091-6
references.pmid: 3259605
references.citation: Immunity. 1998 Jun;8(6):713-21
references.pmid: 9655485
references.citation: Eur J Immunol. 1993 Jul;23(7):1655-60
references.pmid: 8100777
references.citation: Nat Immunol. 2003 Oct;4(10):991-8
references.pmid: 14502287
references.citation: J Exp Med. 2001 Mar 19;193(6):689-98
references.pmid: 11257136
references.citation: Immunity. 2005 May;22(5):595-606
references.pmid: 15894277
references.citation: Curr Opin Immunol. 1998 Apr;10(2):181-7
references.pmid: 9602307
references.citation: Immunity. 2009 Aug 21;31(2):321-30
references.pmid: 19682928
references.citation: Nature. 1995 Jun 29;375(6534):795-8
references.pmid: 7596413
references.citation: Semin Immunol. 1997 Jun;9(3):171-9
references.pmid: 9200328
references.citation: Eur J Immunol. 1998 Nov;28(11):3456-67
references.pmid: 9842888
references.citation: Immunity. 2009 Oct 16;31(4):565-75
references.pmid: 19833086
references.citation: Immunol Rev. 2003 Feb;191:28-37
references.pmid: 12614349
references.citation: Immunity. 2000 May;12(5):537-46
references.pmid: 10843386
references.citation: Adv Immunol. 1999;71:1-76
references.pmid: 9917910
references.citation: PLoS One. 2010 Jan 26;5(1):e8899
references.pmid: 20126650
references.citation: Immunity. 2009 Aug 21;31(2):331-41
references.pmid: 19682929
references.citation: J Immunol. 2010 Feb 1;184(3):1268-79
references.pmid: 20038637
references.citation: J Immunol. 1999 Sep 15;163(6):3076-82
references.pmid: 10477572
references.citation: Eur J Immunol. 1997 Feb;27(2):544-53
references.pmid: 9045929
references.citation: Immunol Rev. 1998 Oct;165:87-94
references.pmid: 9850854
references.citation: Eur J Immunol. 1992 Aug;22(8):2185-8
references.pmid: 1386319
references.citation: Nat Rev Immunol. 2002 May;2(5):336-45
references.pmid: 12033739
references.citation: Proc Natl Acad Sci U S A. 2009 May 19;106(20):8308-13
references.pmid: 19416854
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8
references.pmid: 19617548
references.citation: Clin Immunol Immunopathol. 1998 Feb;86(2):121-33
references.pmid: 9473374
references.citation: Semin Immunol. 1999 Aug;11(4):239-49
references.pmid: 10441210
references.citation: Science. 2000 Oct 6;290(5489):127-31
references.pmid: 11021796
references.citation: Nat Immunol. 2006 Sep;7(9):995-1003
references.pmid: 16878135
references.citation: Immunity. 2002 Jun;16(6):827-38
references.pmid: 12121664
references.citation: J Immunol. 2006 Nov 1;177(9):6038-43
references.pmid: 17056529
references.citation: Int J Biochem Cell Biol. 2010 Mar;42(3):429-32
references.pmid: 19647094
references.citation: Blood. 2009 Jul 16;114(3):564-71
references.pmid: 19443662
references.citation: Curr Opin Immunol. 2006 Oct;18(5):527-33
references.pmid: 16879956
references.citation: Immunity. 2005 May;22(5):583-93
references.pmid: 15894276
references.citation: J Immunol. 2002 Jun 1;168(11):5699-708
references.pmid: 12023369
references.citation: Nat Immunol. 2003 Oct;4(10):999-1008
references.pmid: 12970761
references.citation: Annu Rev Immunol. 1995;13:93-126
references.pmid: 7612239
references.citation: Annu Rev Immunol. 1996;14:511-32
references.pmid: 8717523
references.citation: J Immunol. 2007 Oct 1;179(7):4635-44
references.pmid: 17878361
references.citation: Eur J Immunol. 2001 Jan;31(1):205-14
references.pmid: 11265636
references.citation: Science. 2007 Jan 12;315(5809):230-3
references.pmid: 17218525
references.citation: J Immunol. 2010 Feb 15;184(4):1675-9
references.pmid: 20061408
references.citation: Nat Immunol. 2009 Apr;10(4):427-36
references.pmid: 19270712
references.citation: Immunity. 2008 Jul 18;29(1):90-100
references.pmid: 18585064
references.citation: Annu Rev Immunol. 2000;18:975-1026
references.pmid: 10837080
references.citation: Annu Rev Immunol. 1999;17:829-74
references.pmid: 10358775
references.citation: Mol Cell Biol. 2006 Nov;26(22):8655-65
references.pmid: 16966372
references.citation: J Immunol. 2009 May 15;182(10):5904-8
references.pmid: 19414740
references.citation: Science. 2000 Jan 14;287(5451):314-6
references.pmid: 10634788
references.citation: J Exp Med. 2008 May 12;205(5):1173-86
references.pmid: 18443226