mRNA expression pattern of insulin-like growth factor components of granulosa cells and cumulus cells in women with and without polycystic ovary syndrome according to oocyte maturity.
The mRNA expression of insulin-like growth factor (IGF) components was investigated in granulosa cells (GCs) and cumulus cells (CCs) sampled from immature and mature follicles in women with and without polycystic ovary syndrome (PCOS). Gene expression for IGF-binding protein (IGFBP) 3 in GCs definitely differed between normal women and women with PCOS, whereas increase in IGF-I and IGF receptor (IGFR) 2 mRNA in mature-follicle GCs, increase in IGF-II, IGFR-1, and IGFBP-4 mRNA in immature-follicle GCs, increase in IGFR-2 and IGFBP-2 mRNA in mature-follicle CCs, and increase IGFBP-6 mRNA in immature-follicle CCs were observed in both normal women and women with PCOS.
Kwon
Hwang
H
CHA Fertility Center of Bundang CHA General Hospital, CHA Research Institute, and Graduate School of Life Science and Biotechnology, College of Medicine, CHA University, Seongnam, South Korea. khlsm98@dreamwiz.com
Choi
Dong-Hee
DH
Bae
Jee-Hyeon
JH
Kim
Ji-Hyang
JH
Kim
Young-Sang
YS
D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D002986:Clinical Trials as Topic; D054885:Cumulus Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D006107:Granulosa Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics / Q000378:metabolism; D008597:Menstrual Cycle / Q000235:genetics / Q000378:metabolism; D054315:Oocyte Retrieval; D009865:Oocytes / Q000378:metabolism / Q000502:physiology*; D009866:Oogenesis / Q000235:genetics / Q000502:physiology; D006080:Ovarian Follicle / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D013002:Somatomedins / Q000235:genetics* / Q000378:metabolism
D018969:Insulin-Like Growth Factor Binding Proteins; D012333:RNA, Messenger; D013002:Somatomedins