title: A comparison of nonlinear filtering approaches in the context of an HIV model.
abstract: In this paper three different filtering methods, the Extended Kalman Filter (EKF), the Gauss-Hermite Filter (GHF), and the Unscented Kalman Filter (UKF), are compared for state-only and coupled state and parameter estimation when used with log state variables of a model of the immunologic response to the human immunodeficiency virus (HIV) in individuals. The filters are implemented to estimate model states as well as model parameters from simulated noisy data, and are compared in terms of estimation accuracy and computational time. Numerical experiments reveal that the GHF is the most computationally expensive algorithm, while the EKF is the least expensive one. In addition, computational experiments suggest that there is little difference in the estimation accuracy between the UKF and GHF. When measurements are taken as frequently as every week to two weeks, the EKF is the superior filter. When measurements are further apart, the UKF is the best choice in the problem under investigation.
authors.affiliation: Center for Research in Scientific Computation, Raleigh, NC 27695-8205, United States. htbanks@ncsu.edu
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Banks
authors.forename: Shuhua
authors.initials: S
authors.lastname: Hu
authors.forename: Zackary R
authors.initials: ZR
authors.lastname: Kenz
authors.forename: Hien T
authors.initials: HT
authors.lastname: Tran
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D018791:CD4 Lymphocyte Count; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D006801:Humans; D008954:Models, Biological; D017711:Nonlinear Dynamics