A preliminary study of the use of bioimpedance in the screening of squamous tongue cancer.
Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objective of this study was to study the electrical properties of cancerous tongue tissue (CTT) and normal tongue tissue (NTT). Five tongue cancer patients participated in this study. A disposable probe incorporating four silver electrodes was used to measure the electrical properties of CTT and the surrounding NTT of patients. Measurements were performed at six frequencies: 20 Hz; 50 kHz; 1.3 MHz; 2.5 MHz; 3.7 MHz; and 5 MHz, with the amplitude of the applied voltage limited to 200mV. Four measurement parameters of impedance (Z), phase angle (theta), real part of impedance (R), and imaginary part of impedance (X) of tongue tissue were assessed to see if there was any significant difference in the values obtained in CTT and surrounding NTT. The intraclass correlation coefficient showed that all measurements were reliable. A significant difference (P < 0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT. It was also found that Z and R of CTT were generally smaller than that of surrounding NTT. In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.
Ching
Congo Tak-Shing
CT
Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou, Taiwan.
Sun
Tai-Ping
TP
Huang
Su-Hua
SH
Hsiao
Chin-Sung
CS
Chang
Ching-Haur
CH
Huang
Shiow-Yuan
SY
Chen
Yi-Juai
YJ
Cheng
Chi-Sheng
CS
Shieh
Hsiu-Li
HL
Chen
Chung-Yuan
CY
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D010865:Pilot Projects; D010992:Plethysmography, Impedance / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014062:Tongue Neoplasms / Q000175:diagnosis*
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