Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.
A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.
Lorsch
Jon R
JR
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. jlorsch@jhmi.edu
Dever
Thomas E
TE
D018387:Codon, Initiator; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D009154:Mutation; D010442:Peptide Chain Initiation, Translational; D010448:Peptide Initiation Factors / Q000737:chemistry; D010641:Phenotype; D014176:Protein Biosynthesis; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins; D012270:Ribosomes / Q000378:metabolism*; D000097574:Eukaryotic Translation Initiation Factor 5A
D018387:Codon, Initiator; D015852:Eukaryotic Initiation Factor-2; D010448:Peptide Initiation Factors; D016601:RNA-Binding Proteins; D000097574:Eukaryotic Translation Initiation Factor 5A
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