New stilbene dimers against amyloid fibril formation.
Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-beta peptide (Abeta) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and epsilon-viniferin glucoside demonstrated a strong inhibition of the aggregation process.
Rivière
Céline
C
GESVAB (EA 3675), Université de Bordeaux, ISVV Bordeaux-Aquitaine, 71, Avenue Edouard Bourleaux, 33883 Villenave d'Ornon cedex, France.
Papastamoulis
Yorgos
Y
Fortin
Pierre-Yves
PY
Delchier
Nicolas
N
Andriamanarivo
Soahary
S
Waffo-Teguo
Pierre
P
Kapche
Gilbert D W F
GD
Amira-Guebalia
H
H
Delaunay
Jean-Claude
JC
Mérillon
Jean-Michel
JM
Richard
Tristan
T
Monti
Jean-Pierre
JP
D000682:Amyloid / Q000737:chemistry*; D019281:Dimerization; D013267:Stilbenes / Q000737:chemistry*
D000682:Amyloid; D013267:Stilbenes