title: Unraveling mechanisms of homeostatic synaptic plasticity.
abstract: Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.
authors.affiliation: MRC Cell Biology Unit and MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Karine
authors.initials: K
authors.lastname: Pozo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Goda
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000502:physiology*; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
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