title: Molecular size of collagen peptide reverses the permeability of Caco-2 cells.
abstract: Intestinal permeability to size-classified fish collagen peptides (FCPs) was examined using Caco-2 monolayers. Minimum-sized FCPs were most efficiently transported across the Caco-2 monolayers. Permeability depended on peptide size. It was independent of the H(+)-coupled peptide transport system but was associated with tight junction permeability, suggesting that the paracellular pathway is responsible for transepithelial transport of collagen peptides.
authors.affiliation: R&D Center, Nippon Meat Packers, Inc, Tsukuba, Ibaraki, Japan. kazu.shimizu@nipponham.co.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shimizu
authors.forename: Mikako
authors.initials: M
authors.lastname: Sato
authors.forename: Youzuo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kouguchi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takahata
authors.forename: Fumiki
authors.initials: F
authors.lastname: Morimatsu
authors.forename: Makoto
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D018938:Caco-2 Cells; D003094:Collagen / Q000737:chemistry*; D005399:Fishes; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism*; D010539:Permeability
chemical_list: D010446:Peptide Fragments; D003094:Collagen