title: Serum Levels of Natriuretic Peptides in Children before and after Treatment for an Atrial Septal Defect, a Patent Ductus Arteriosus, and a Coarctation of the Aorta-A Prospective Study.
abstract: Background and Objectives. We evaluated and compared the influence of treatment for atrial septal defect (ASD), patent ductus arteriosus (PDA), and coarctation of the aorta (CoA) on serum levels of N-terminal proatriopeptide and N-terminal probrain natriuretic peptide. Correlations between peptide levels and echocardiographic measurements were calculated. Patients and Methods. Peptide levels were measured and echocardiography performed before and 6-12 months after treatment in 21 children with ASD, 25 with PDA, 15 with CoA, and 76 control children. Results. ANPN levels were higher than in controls at baseline in all patient groups, and NT-proBNP in patients with ASD and PDA. Both peptide levels were elevated 6 months after treatment and decreased thereafter. Peptide levels were higher in patients with volume than pressure overload. They correlated with echocardiographic measurements. At the 6-month follow-up, dimensions of the originally overloaded ventricle had normalized only in patients with PDA. Conclusions. After intervention, peptide levels decrease but normalization takes over 6 months. The type of correlation between peptide levels and echocardiography varies according to the loading condition. Measurement of peptide levels can be used for monitoring the course of a patient's heart disease.
authors.affiliation: Department of Pediatrics, University Hospital of Tampere, 33521 Tampere, Finland.
authors.forename: Anneli
authors.initials: A
authors.lastname: Eerola
authors.forename: Eero
authors.initials: E
authors.lastname: Jokinen
authors.forename: Talvikki
authors.initials: T
authors.lastname: Boldt
authors.forename: Ilkka P
authors.initials: IP
authors.lastname: Mattila
authors.forename: Jaana I
authors.initials: JI
authors.lastname: Pihkala
references.citation: Cardiol Young. 2005 Aug;15(4):396-401
references.pmid: 16014188
references.citation: Heart. 2000 Jun;83(6):667-72
references.pmid: 10814626
references.citation: Scand Cardiovasc J. 2007 Dec;41(6):370-7
references.pmid: 17852783
references.citation: Cathet Cardiovasc Diagn. 1998 Sep;45(1):27-32
references.pmid: 9736347
references.citation: J Am Coll Cardiol. 2006 Mar 7;47(5):1060-6
references.pmid: 16516094
references.citation: Heart. 2003 Aug;89(8):875-8
references.pmid: 12860862
references.citation: Am J Cardiol. 2004 Jun 1;93(11):1374-7, A6
references.pmid: 15165917
references.citation: Curr Probl Pediatr. 1998 Feb;28(2):33-60
references.pmid: 9551314
references.citation: Am J Cardiol. 1994 Apr 1;73(9):698-701
references.pmid: 8166068
references.citation: Pediatr Cardiol. 1997 Mar-Apr;18(2):96-100
references.pmid: 9049120
references.citation: Circulation. 1981 Jun;63(6):1315-22
references.pmid: 7226477
references.citation: Am J Cardiol. 1975 Sep;36(3):302-8
references.pmid: 1166835
references.citation: Am J Cardiol. 1982 Jul;50(1):143-8
references.pmid: 7090997
references.citation: Circulation. 1977 Mar;55(3):479-84
references.pmid: 138489
references.citation: Pediatr Cardiol. 2004 Jul-Aug;25(4):336-40
references.pmid: 14735252
references.citation: Acta Paediatr. 2002;91(6):649-52
references.pmid: 12162595
references.citation: Acta Paediatr. 2004 Mar;93(3):340-5
references.pmid: 15124836
references.citation: J Pediatr. 1987 Sep;111(3):335-42
references.pmid: 2957477
references.citation: Am J Cardiol. 2001 Mar 15;87(6):748-52
references.pmid: 11249895
references.citation: Heart. 2000 Sep;84(3):320-6
references.pmid: 10956299
references.citation: Eur J Heart Fail. 2000 Jun;2(2):161-5
references.pmid: 10856729
references.citation: Pediatrics. 1988 Oct;82(4):639-43
references.pmid: 2971922
references.citation: Eur J Endocrinol. 1995 Aug;133(2):207-9
references.pmid: 7655645
references.citation: Scand J Clin Lab Invest. 2004;64(5):497-510
references.pmid: 15276915
references.citation: J Am Coll Cardiol. 2001 Jun 15;37(8):2108-13
references.pmid: 11419895
references.citation: Am J Cardiol. 2001 Dec 15;88(12):1450-3, A9
references.pmid: 11741575
references.citation: Pediatr Cardiol. 1992 Jul;13(3):152-8
references.pmid: 1603715
references.citation: Eur J Clin Invest. 2002 Aug;32(8):563-9
references.pmid: 12190955
references.citation: Curr Probl Cardiol. 2004 Dec;29(12):707-69
references.pmid: 15550914
references.citation: Clin Chem. 2003 Sep;49(9):1563-4
references.pmid: 12928255
references.citation: Clin Physiol Funct Imaging. 2005 Sep;25(5):263-9
references.pmid: 16117728
references.citation: Acta Paediatr. 2004 May;93(5):603-7
references.pmid: 15174780
references.citation: Pediatrics. 2003 Oct;112(4):896-9
references.pmid: 14523183
references.citation: Ann Thorac Surg. 2004 Jan;77(1):53-60
references.pmid: 14726034
references.citation: J Am Coll Cardiol. 1994 Jul;24(1):194-200
references.pmid: 8006265
references.citation: Pediatr Res. 1986 Dec;20(12):1328-31
references.pmid: 2948147
references.citation: N Engl J Med. 1990 Dec 13;323(24):1698-700
references.pmid: 2233967
references.citation: Clin Sci (Lond). 2004 Sep;107(3):297-302
references.pmid: 15142035
references.citation: Am J Cardiol. 1978 Mar;41(3):487-93
references.pmid: 626126
references.citation: J Card Fail. 2005 Jun;11(5 Suppl):S81-3
references.pmid: 15948107
references.citation: Am J Cardiol. 2005 May 15;95(10):1255-7
references.pmid: 15878007
references.citation: Curr Med Chem Cardiovasc Hematol Agents. 2005 Apr;3(2):87-98
references.pmid: 15853696
references.citation: Catheter Cardiovasc Interv. 2007 Feb 15;69(3):432-41; discussion 442
references.pmid: 17195197
references.citation: Am J Cardiol. 2005 Feb 15;95(4):545-6
references.pmid: 15695153
references.citation: Can J Physiol Pharmacol. 2001 Aug;79(8):705-14
references.pmid: 11558679
references.citation: Br Heart J. 1970 Nov;32(6):820-6
references.pmid: 5212356