title: Neonatal status epilepticus due to lamination disorder without significant cell death.
abstract: BACKGROUND
  Malformations of the cerebral cortex may be associated with severe epilepsy and status epilepticus. It has been shown that status epilepticus models induce excitotoxic cell death. In humans, very few data are available.
  
  
  RESULTS
  We report a case of a multifocal disorder of the lamination diagnosed in a neonate, born at 30 weeks' gestation, who died from a refractory status epilepticus at two months and half. This abnormality was not detected by repeated MRI studies. Only microscopic investigations permitted to identify this disorder of the lamination. We found also little cell death or cell loss.
  
  
  CONCLUSIONS
  Our report highlights the possible false negative results of MRI in a newborn. We can also discuss that immature human brain maybe less sensitive to neuronal injury than mature as described in animal models.
authors.affiliation: Department of Neuropathology, University Hospital, Lille, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Ansart-Franquet
authors.forename: Louise
authors.initials: L
authors.lastname: Devisme
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Lamblin
authors.forename: Gustavo
authors.initials: G
authors.lastname: Soto-Ares
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Renard-Edun
authors.forename: Nadine
authors.initials: N
authors.lastname: Kacet
authors.forename: Pierre
authors.initials: P
authors.lastname: Gressens
authors.forename: Stéphane
authors.initials: S
authors.lastname: Auvin
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities*; D016923:Cell Death; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D013226:Status Epilepticus / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology*