Serum response factor: look into the gut.
Serum response factor (SRF) is a transcription factor that regulates many genes involved in cellular activities such as proliferation, migration, differentiation, angiogenesis, and apoptosis. Although it has only been known for about two decades, SRF has been studied extensively. To date, over a thousand SRF studies have been published, but it still remains a hot topic. Due to its critical role in mesoderm-derived tissues, most of the SRF studies focused on muscle structure/function, cardiovascular development/maintenance, and smooth muscle generation/repair. Recently, SRF has received more attention in the digestive field and several important discoveries have been made. This review will summarize what we have learned about SRF in the gastrointestinal tract and provide insights into possible future directions in this area.
Modak
Cristina
C
Chai
Jianyuan
J
D000818:Animals; D004066:Digestive System Diseases / Q000209:etiology / Q000503:physiopathology; D004068:Digestive System Physiological Phenomena; D006801:Humans; D026362:Serum Response Factor / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
C476858:SRF protein, human; D026362:Serum Response Factor
J Physiol Pharmacol. 2002 Jun;53(2):289-94
12120903
J Gastrointest Cancer. 2009;40(3-4):83-90
19859834
Genome Res. 2006 Feb;16(2):197-207
16365378
Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1521-33
11893590
J Biol Chem. 2001 Oct 26;276(43):40033-40
11514558
J Physiol Pharmacol. 2002 Jun;53(2):147-57
12120892
Gut. 2007 May;56(5):621-30
17068115
Lab Invest. 2006 Oct;86(10):1020-36
16894357
J Clin Invest. 2000 Dec;106(11):1321-30
11104785
Hepatology. 2009 May;49(5):1645-54
19205030
Gastroenterology. 2007 Dec;133(6):1948-59
18054566
Cell. 1986 Aug 15;46(4):567-74
3524858
Gastroenterology. 2007 Dec;133(6):1960-70
18054567
J Biol Chem. 2001 Apr 27;276(17):14482-9
11278942
Genesis. 2002 Feb;32(2):124-6
11857797
Gastroenterology. 2002 Dec;123(6):1962-71
12454853
J Biol Chem. 2005 Feb 11;280(6):4906-12
15576363
Gastroenterology. 2007 Dec;133(6):2052-5
18054578
FASEB J. 2004 Aug;18(11):1264-6
15180964
J Biol Chem. 2000 Aug 18;275(33):25681-9
10829028
Nature. 1984 Oct 4-10;311(5985):433-8
6090941
Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G996-G1001
17170024
Dig Dis Sci. 2005 Oct;50 Suppl 1:S24-33
16184417
Genesis. 2000 Sep;28(1):15-22
11020712
Cell. 1988 Dec 23;55(6):989-1003
3203386
Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7400-5
9207103
J Biol Chem. 2001 May 25;276(21):18313-20
11359793
Oncol Rep. 2009 Jan;21(1):57-63
19082443
J Biol Chem. 1999 Dec 31;274(53):38071-82
10608876
Development. 1994 Apr;120(4):743-53
7600954
Biochimie. 2010 May;92(5):455-63
20144681
Gastroenterology. 2004 Jun;126(7):1809-18
15188176
Cancer Lett. 1997 Nov 11;119(2):137-41
9570363
J Surg Res. 2004 Sep;121(1):92-100
15313381
Mol Cell Biol. 1993 Oct;13(10):6260-73
8413226
Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1782-92
11247792
EMBO J. 1998 Nov 2;17(21):6289-99
9799237