title: Fungal polyketide azaphilone pigments as future natural food colorants?
abstract: The recent approval of fungal carotenoids as food colorants by the European Union has strengthened the prospects for fungal cell factories for the production of polyketide pigments. Fungal production of colorants has the main advantage of making the manufacturer independent of the seasonal supply of raw materials, thus minimizing batch-to-batch variations. Here, we review the potential of polyketide pigments produced from chemotaxonomically selected non-toxigenic fungal strains (e.g. Penicillium and Epicoccum spp.) to serve as food colorants. We argue that the production of polyketide azaphilone pigments from such potentially safe hosts is advantageous over traditional processes that involve Monascus spp., which risks co-production of the mycotoxin citrinin. Thus, there is tremendous potential for the development of robust fungal production systems for polyketide pigments, both to tailor functionality and to expand the color palette of contemporary natural food colorants.
authors.affiliation: Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. sam@bio.dtu.dk
authors.forename: Sameer A S
authors.initials: SA
authors.lastname: Mapari
authors.forename: Ulf
authors.initials: U
authors.lastname: Thrane
authors.forename: Anne S
authors.initials: AS
authors.lastname: Meyer
mesh_terms: D001578:Benzopyrans / Q000302:isolation & purification / Q000378:metabolism* / Q000592:standards / Q000633:toxicity; D001709:Biotechnology / Q000379:methods*; D005062:European Union; D005505:Food Coloring Agents / Q000302:isolation & purification / Q000378:metabolism* / Q000592:standards / Q000633:toxicity; D005516:Food Microbiology; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D018942:Macrolides / Q000302:isolation & purification / Q000378:metabolism* / Q000592:standards / Q000633:toxicity; D010860:Pigments, Biological / Q000302:isolation & purification / Q000378:metabolism* / Q000592:standards / Q000633:toxicity
chemical_list: D001578:Benzopyrans; D005505:Food Coloring Agents; D018942:Macrolides; D010860:Pigments, Biological; C494154:azaphilone