title: [Acute hepatitis of unspecified etiology: etiological structure and clinical-laboratory characteristics].
abstract: The straight line nucleic acids detection method of viruses and wide spectrum of virus antigens immunodiagnostics in acute hepatitis of unknown etiology patients has allowed verifying the diagnosis at 19% cases (a viral hepatitis A, C or E). Results of research do not allow to consider hepatotropic viruses HGV, TTV, PV B19, EBV, CMV, HHV 1, 2, 6 and 8 type, NV-F as etiological agents at the majority of patients of investigated group, and the data of the anamnesis and a clinical and laboratory picture of a current of disease does not allow to exclude at 29.4% of patients a drug-induced hepatitis. Despite detailed molecular-biological and immunological inspection of patients, at 37.9% of acute hepatitis of unknown etiology patients it was not possible to establish a connection with hepatitis and defined etiological factor (the infectious agent).
authors.forename: N D
authors.initials: ND
authors.lastname: Iushchuk
authors.forename: E V
authors.initials: EV
authors.lastname: Tsyganova
authors.forename: O O
authors.initials: OO
authors.lastname: Znoĭko
authors.forename: G N
authors.initials: GN
authors.lastname: Karetkina
authors.forename: S A
authors.initials: SA
authors.lastname: Solonin
authors.forename: M I
authors.initials: MI
authors.lastname: Mikhaĭlov
authors.forename: M G
authors.initials: MG
authors.lastname: Isaguliants
authors.forename: T V
authors.initials: TV
authors.lastname: Petrova
authors.forename: V I
authors.initials: VI
authors.lastname: Kashirin
authors.forename: D S
authors.initials: DS
authors.lastname: Cheshik
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D006518:Hepatitis Viruses / Q000235:genetics / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D055815:Young Adult