Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) bis-imine fluorescent adducts.
The synthesis of a series of malondialdehyde (MDA) fluorescent adducts that mimic the well-known pentamethine cyanine dyes is reported. This new subclass of bis-imino dyes shares some common spectroscopic properties with their polymethine analogues although absorbing at significantly shorter wavelengths. A small library of trimethine and pentamethine cyanine dye bis-imino analogues have been synthesised and characterised that cover a spectral range from blue to orange. Of particular interest is their capacity to act as mono- and bis-alkylating agents of nucleosides in general and of cytidine (and 2'-deoxycytidine) in particular.
Meguellati
Kamel
K
Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, CNRS UMR 7006, 8, allée Gaspard Monge, BP 70028, 67083 Strasbourg Cédex, France.
Spichty
Martin
M
Ladame
Sylvain
S
D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D008315:Malondialdehyde / Q000737:chemistry*; D015394:Molecular Structure
D005456:Fluorescent Dyes; D007097:Imines; D008315:Malondialdehyde