title: A new phosphonate pendant-armed cross-bridged tetraamine chelator accelerates copper(ii) binding for radiopharmaceutical applications.
abstract: A phosphonate pendant-armed cross-bridged cyclam chelator has been synthesized, complexed to Cu(ii), radiolabeled with (64)Cu under mild conditions, and its biodistribution studied.
authors.affiliation: Department of Chemistry, University of New Hampshire, Durham, New Hampshire 03824, USA.
authors.forename: Dannon J
authors.initials: DJ
authors.lastname: Stigers
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ferdani
authors.forename: Gary R
authors.initials: GR
authors.lastname: Weisman
authors.forename: Edward H
authors.initials: EH
authors.lastname: Wong
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Anderson
authors.forename: James A
authors.initials: JA
authors.lastname: Golen
authors.forename: Curtis
authors.initials: C
authors.lastname: Moore
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold
mesh_terms: D000588:Amines / Q000737:chemistry*; D001665:Binding Sites; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D002614:Chelating Agents; D063065:Organophosphonates; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D003300:Copper