The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events.
Secreted Frizzled Related Proteins (Sfrps) are a family of secreted proteins that can bind both to Wnt ligands and Frizzled receptors, thereby modulating the Wnt signalling cascades. Recent studies have shown that Sfrps can also interact with Wnt unrelated molecules such as RANKL, a member of the tumor necrosis factor family, Tolloid metalloproteinases or integrin-fibronectin complexes. Alterations in the levels of Sfrp expression have been recently associated with different pathological conditions, including tumor formation and bone and myocardial disorders. Here, we summarise the evidence that relates Sfrps with these diseases and discuss how the proposed multiple Sfrp interactions with Wnt related and unrelated pathways may explain their implication in such diverse pathologies.
Esteve
Pilar
P
Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal (CSIC), Spain. PilarEsteve@cajal.csic.es
Bovolenta
Paola
P
D001847:Bone Diseases / Q000378:metabolism* / Q000473:pathology; D005353:Fibronectins / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D053245:RANK Ligand / Q000378:metabolism; D015398:Signal Transduction; D055394:Tolloid-Like Metalloproteinases / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism; D000094742:Secreted Frizzled-Related Proteins
D005353:Fibronectins; D039081:Integrin alpha5beta1; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D053245:RANK Ligand; D055394:Tolloid-Like Metalloproteinases; D051153:Wnt Proteins; C117636:SFRP1 protein, human; D000094742:Secreted Frizzled-Related Proteins; C109618:SFRP2 protein, human; C505688:TNFSF11 protein, human