Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI.
Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.
Schühle
Daniel T
DT
Delft University of Technology, Department of Biotechnology, Biocatalysis and Organic Chemistry, Julianalaan 136, 2628 BL Delft, The Netherlands.
van Rijn
Patrick
P
Laurent
Sophie
S
Vander Elst
Luce
L
Muller
Robert N
RN
Stuart
Marc C A
MC
Schatz
Jürgen
J
Peters
Joop A
JA
D047250:Calixarenes / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D004058:Diffusion; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D009942:Organometallic Compounds / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D002614:Chelating Agents; D003287:Contrast Media; D006571:Heterocyclic Compounds; D008081:Liposomes; D009942:Organometallic Compounds; D014867:Water; D047250:Calixarenes; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate