[Evaluation properties of hydrogels with simvastatin prepared on Carbopol 2020].
The inhibitors of 3-hydroxy-3-methyloglutaryl coenzyme-A reductase are very popular in hipercholesterolemia therapy. According to current publications statins can be also used in other medical indications. In addition to fundamental cholesterol lowering activity statins give other effects as well, for example immunomodulating and anti-inflammatory effect, they promote bone mineralization. The anti-inflammatory activity has been described in few articles and clinical letters. Systemic or topical use of statins can be beneficial in alopecia, erythema, psoriasis. In the following paper prepared and tested formulations including simvastatin gel obtained from the Carbopolu 2020 with the addition of selected excipients: Tween 20, propylene glycol, glycerol, PEG 400. Particle size distributions, rheological characteristic of formulations and pharmaceutical availability were carried over to all formulations.
Owczarek
Artur
A
Katedra i Zakład Technologii Postaci Leku, Akademia Medyczna im. Piastów Slaskich we Wrocławiu. artur@ktpl.am.wroc.pl
Pluta
Janusz
J
Kogut
Joanna
J
D000180:Acrylic Resins; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry*; D012212:Rheology; D019821:Simvastatin / Q000737:chemistry*
D000180:Acrylic Resins; D004337:Drug Carriers; D020100:Hydrogels; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D011145:Polyvinyls; C006912:carboxypolymethylene; D019821:Simvastatin