[New therapeutic approaches to special diseases of the small intestine].
Numerous reports on fundamental research and clinical studies have appeared in the past 1-2 decades which have contributed decisively to understanding inflammatory diseases of the small intestine. Illustrated by the examples of Crohn's disease, celiac disease, refractory sprue, and Whipple's disease, the rationale and evidence for treatment approaches are presented that are based on these pathophysiological findings. Emphasis is placed on modulation of the intestinal flora with antibiotics and probiotics as well as immunomodulatory/immunosuppressive measures with so-called biological agents. Future treatment options that directly intervene in the disease process are discussed.
Schumann
M
M
Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité Centrum 10, Charité Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany. michael.schumann@charite.de
Herrlinger
K
K
Zeitz
M
M
Stange
E F
EF
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007410:Intestinal Diseases / Q000188:drug therapy*; D007422:Intestines / Q000187:drug effects*; D019936:Probiotics / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D007166:Immunosuppressive Agents
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