title: In vivo acquisition of a plasmid-mediated bla(KPC-2) gene among clonal isolates of Serratia marcescens.
abstract: Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of these cases, the patients were initially infected by carbapenem-susceptible S. marcescens isolates. Molecular typing and plasmid analysis suggested that all three patients had clonally indistinguishable isolates of S. marcescens that acquired a plasmid-mediated bla(KPC-2) gene during the hospitalization.
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece. atsakris@med.uoa.gr
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsakris
authors.forename: Evangelia
authors.initials: E
authors.lastname: Voulgari
authors.forename: Aggeliki
authors.initials: A
authors.lastname: Poulou
authors.forename: Maria
authors.initials: M
authors.lastname: Kimouli
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Ranellou
authors.forename: Olga
authors.initials: O
authors.lastname: Kosmopoulou
authors.forename: Dimitra
authors.initials: D
authors.lastname: Petropoulou
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology / Q000627:therapeutic use; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids / Q000235:genetics*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology; D016868:Serratia Infections / Q000188:drug therapy / Q000382:microbiology*; D012706:Serratia marcescens / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases
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