Relationship of adipokines and non-esterified fatty acid to the insulin resistance in non-diabetic individuals.
BACKGROUND
Altered secretion of adipokines and non-esterified fatty acid (NEFA) seems to play a pivotal role in the abdominal obesity-related insulin resistance (IR).


OBJECTIVE
To determine semi-quantitatively the impact of serum NEFA, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin, and resistin levels on IR measured by homeostasis model assessment (HOMA-IR). MATERIAL/SUBJECTS: Seventy-four Caucasian subjects forming 3 age-, and sex-matched groups were included into the study [Group 1 and 2: non-diabetic obese patients, no.= 25, body mass index (BMI): 28-39.9 kg/m(2), no.=25, BMI≥40 kg/m(2), respectively, and Group 3: 24 healthy, normal weight control subjects].


METHODS
Serum levels of NEFA and adipokines as well as other metabolic variables including HOMA-IR were measured.


RESULTS
HOMA-IR was associated positively with BMI, waist circumference, serum NEFA, leptin, IL-6, and TNF-α levels, negatively with adiponectin, with no significant relation to resistin. In multiple regression analyses, of these factors leptin was a strong, IL-6 and adiponectin were weak independent predictors of HOMA-IR, while the others were not significant determinants of HOMA-IR. However, even together, they explained only 35-36% of variance of HOMAIR.


CONCLUSIONS
Although IR has associations with many of the investigated parameters, of these, only serum level of leptin, and in lesser degree IL-6 and adiponectin are independent determinants of the severity of IR. Moreover, even together they explain only a minority of variance IR.
Peti
A
A
Institute of Laboratory Medicine, School of Medicine, University of Pécs, Pécs, Hungary.
Juhasz
A
A
Kenyeres
P
P
Varga
Z
Z
Seres
I
I
Kovacs
G L
GL
Paragh
G
G
Bajnok
L
L
D054392:Adipokines / Q000032:analysis / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism; D004951:Esterification; D005227:Fatty Acids / Q000032:analysis / Q000097:blood*; D005260:Female; D006262:Health; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055815:Young Adult
D054392:Adipokines; D005227:Fatty Acids
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