title: [The effect of serotonin precursor 5-hydroxytryptophan and neurotoxic analogue 5,7-dihydroxytryptamine on defensive conditioning in a snail].
abstract: This study is devoted to investigation of the influence of precursor of serotonin 5-hydroxytryptophane (5-HTP) and neurotoxic analogue 5,7-dihydroxytryptamine (5,7-DHT) on defensive conditioning and electrical characteristics of command neurones of defensive behaviour after learning. Snails injected with 5-HTP learned faster as compared to control group injected with physiological solution. After the 5,7-DHT injection, snails failed to form the conditioned reflex. Injection of 5-HTP after the preliminary injection of neurotoxin 5,7-DHT restored the capability of snails for learning. Injections of 5-HTP prevented the effect of 5,7-DHT at the behavioural level, but not at the level of electrical characteristics of the command neurones.
authors.forename: R R
authors.initials: RR
authors.lastname: Tagirova
authors.forename: I B
authors.initials: IB
authors.lastname: Deriabina
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gaĭnutdinova
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gaĭnutdinov
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000378:metabolism* / Q000494:pharmacology; D006916:5-Hydroxytryptophan / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D003213:Conditioning, Psychological; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000096:biosynthesis / Q000502:physiology*
chemical_list: D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D006916:5-Hydroxytryptophan