title: Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion.
abstract: BACKGROUND
  Ventilator-induced lung injury (VILI) is a recognized complication of mechanical ventilation. Although the specific mechanism by which mechanical ventilation causes lung injury remains an active area of study, the application of positive end expiratory pressure (PEEP) reduces its severity. We have previously reported that VILI is spatially heterogeneous with the most severe injury in the dorsal-caudal lung. This regional injury heterogeneity was abolished by the application of PEEP = 8 cm H2O. We hypothesized that the spatial distribution of lung injury correlates with areas in which cyclical airway collapse and recruitment occurs.
  
  
  METHODS
  To test this hypothesis, rabbits were mechanically ventilated in the supine posture, and regional ventilation distribution was measured under four conditions: tidal volumes (VT) of 6 and 12 ml/kg with PEEP levels of 0 and 8 cm H2O.
  
  
  RESULTS
  We found that relative ventilation was sequentially redistributed towards dorsal-caudal lung with increasing tidal volume. This sequential ventilation redistribution was abolished with the addition of PEEP.
  
  
  CONCLUSIONS
  These results suggest that cyclical airway collapse and recruitment is regionally heterogeneous and spatially correlated with areas most susceptible to VILI.
authors.affiliation: Department of Medicine, University of Tennessee Health Sciences Center, 956 Court Ave E222, Memphis, TN 38163 USA. ssincla1@uthsc.edu
authors.forename: Scott E
authors.initials: SE
authors.lastname: Sinclair
authors.forename: Nayak L
authors.initials: NL
authors.lastname: Polissar
authors.forename: William A
authors.initials: WA
authors.lastname: Altemeier
mesh_terms: D000818:Animals; D005260:Female; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology*; D008297:Male; D008863:Microspheres; D023421:Models, Animal; D011175:Positive-Pressure Respiration / Q000379:methods*; D011187:Posture / Q000502:physiology*; D011817:Rabbits; D015656:Respiratory Mechanics / Q000502:physiology; D013990:Tidal Volume / Q000502:physiology; D055397:Ventilator-Induced Lung Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
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