Juvenile idiopathic arthritis and Wegener's granulomatosis--causal or casual acquaintances?
We report two cases of long-term juvenile idiopathic arthritis which developed recurrent subglottic stenosis secondary to localized Wegener's granulomatosis. In both cases, the biopsies taken from the affected region shown granulomatous vasculitis with multinucleated giant cells. Both patients presented positive serology for antineutrophil cytoplasmic antibodies by immunofluorescence (c-ANCA) and ELISA (PR3). The involvement or other organs was ruled out at the time of Wegener's granulomatosis diagnosis and during follow-up. To our knowledge, this is the first report of the association between juvenile idiopathic arthritis and a localized form of Wegener's granulomatosis.
Jakez-Ocampo
Juan
J
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan. 14000 Mexico D.F., Mexico. jjakez_ocampo@yahoo.com
Ramírez
Jacqueline
J
Paulín-Vera
Carmen María
CM
Flores-Suárez
Luis Felipe
LF
Reyes
Edgardo
E
Llorente
Luis
L
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001171:Arthritis, Juvenile / Q000150:complications*; D001706:Biopsy; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D013997:Time Factors; D014657:Vasculitis / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic