title: Sub-maximal exercise altered the prednisolone absorption pattern.
abstract: OBJECTIVE
  Prednisolone has been widely used due to its relatively short pituitary inhibition and its moderate potency. Exercise is one of the non-pharmacological interventions for glucocorticoid- induced osteoporosis prevention. However, the effects of exercise on the pharmacokinetics of prednisolone were unclear. The purpose of this study was to evaluate the effects of sub-maximal exercise on the pharmacokinetics of prednisolone.
  
  
  METHODS
  A randomized, double-blind, cross-over experimental design was used. Subjects needed to undertake two trials: a non-exercise trial (NE) and an exercise trial (E). After the first blood sampling, the subjects consumed 5 mg of prednisolone with 100 mL of water and then took a rest for 30 min. In the E trial, subjects cycled at 70% VO(2max) intensity until exhaustion. When subjects underwent the NE trial, they remained seated for the duration of the experiment. Serial blood samples were collected at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 hr after prednisolone administration. Prednisolone and cortisol concentration were analyzed with a validated high performance liquid chromatographic method.
  
  
  RESULTS
  This study indicated that the maximum concentration of the E trial was significantly lower than the NE trial (p<.05). However, the area under the plasma concentration-time, half life, the time-averaged total body clearance, and the apparent volume of the distribution showed no significant difference between two trials. The mean percentage change of cortisol of E trail was significantly higher than NE trail (p<.05).
  
  
  CONCLUSIONS
  The results suggested that sub-maximal exercise altered the prednisolone absorption pattern.
authors.affiliation: Department of Geriatric Health Promotion, Kainan University, Taoyuan, Taiwan.
authors.forename: Kuei-Yu
authors.initials: KY
authors.lastname: Chien
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Chen
authors.forename: Jia
authors.initials: J
authors.lastname: Hsu
authors.forename: Ryh-Nan
authors.initials: RN
authors.lastname: Pan
authors.forename: Jih-Heng
authors.initials: JH
authors.lastname: Li
authors.forename: Chia-Hua
authors.initials: CH
authors.lastname: Kuo
authors.forename: Mei-Chich
authors.initials: MC
authors.lastname: Hsu
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D019540:Area Under Curve; D001642:Bicycling; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D018592:Cross-Over Studies; D015444:Exercise; D005938:Glucocorticoids / Q000493:pharmacokinetics* / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011239:Prednisolone / Q000493:pharmacokinetics* / Q000494:pharmacology; D013997:Time Factors; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone; D006854:Hydrocortisone