title: Protein secretion: unconventional exit by exophagy.
abstract: Certain secreted proteins bypass the canonical exit pathway from cells. Two studies now shed light on the unconventional secretion route taken by the yeast acyl-coenzyme A-binding protein: this protein is sequestered into autophagic vesicles that are re-routed to the plasma membrane where their content is released to the extracellular space.
authors.affiliation: Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0310 Oslo, Norway.
authors.forename: Hilde
authors.initials: H
authors.lastname: Abrahamsen
authors.forename: Harald
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D001343:Autophagy / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology; D026261:Diazepam Binding Inhibitor / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D055571:Secretory Pathway / Q000502:physiology*; D022142:Secretory Vesicles / Q000502:physiology*
chemical_list: C492820:ACB1 protein, S cerevisiae; D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D029701:Saccharomyces cerevisiae Proteins