title: Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection.
abstract: In the current era of organ shortages and long wait times for life-saving transplants, marginal or extended donors are increasingly being considered; one such category of marginal organs is from donors with a previous history of malignancy. Melanoma in particular has been associated with increased risk of developing late recurrence. In this report, we describe a case of fatal donor melanoma transmission to a 64-year-old lung transplant recipient 32 years after surgical excision of the melanoma. Based on this report and review of the available literature, we conclude that a history of donor melanoma, regardless of the stage and time interval from 'curative' surgical resection, should remain a strong relative contraindication to transplantation.
authors.affiliation: University of Alabama, Ryals School of Public Health, Birmingham, AL, USA. ahyav@uphs.upenn.edu
authors.forename: Navkaranbir S
authors.initials: NS
authors.lastname: Bajaj
authors.forename: Christopher
authors.initials: C
authors.lastname: Watt
authors.forename: Denis
authors.initials: D
authors.lastname: Hadjiliadis
authors.forename: Colin
authors.initials: C
authors.lastname: Gillespie
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Haas
authors.forename: Alberto
authors.initials: A
authors.lastname: Pochettino
authors.forename: James
authors.initials: J
authors.lastname: Mendez
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Sterman
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Schuchter
authors.forename: Jason D
authors.initials: JD
authors.lastname: Christie
authors.forename: James C
authors.initials: JC
authors.lastname: Lee
authors.forename: Vivek N
authors.initials: VN
authors.lastname: Ahya
mesh_terms: D046148:Donor Selection; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000209:etiology*; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000601:surgery*; D012878:Skin Neoplasms; D014019:Tissue Donors