title: An association between clotting factor VII and carotid intima-media thickness: the CARDIA study.
abstract: OBJECTIVE
  To investigate associations of procoagulants (factor VII [FVII], FVIII, von Willebrand factor) with subclinical atherosclerosis, we examined participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
  
  
  METHODS
  Clotting factor assays were performed in 1254 participants 23 to 37 years of age (baseline) and repeated at ages 38 through 50 (follow-up). Carotid intima-media thickness (IMT) was measured at follow-up.
  
  
  RESULTS
  Baseline levels of procoagulants (%), mean (SD) were: FVII, 76 (18); FVIII, 102 (38); and von Willebrand factor, 108 (47). At follow-up, all had increased by 40% to 55%. After age adjustment, mean common carotid IMT increased from the lowest to the highest tertile of FVII in the total group (0.787 to 0.801; P=0.007), in whites (0.772 to 0.790; P=0.002), and in men (0.807 to 0.827; P=0.015). All associations were attenuated by multivariable adjustment. However, participants with FVII values in the highest tertile at one or both examinations, compared with those in the lowest tertile, had greater common carotid IMT after age and multivariable adjustment (0.806 versus 0.778; P<0.05). Baseline FVIII was associated with greater internal carotid IMT in the total group, in whites, and in women after age adjustment but not multivariable adjustment. No associations were seen for von Willebrand factor.
  
  
  CONCLUSIONS
  FVII is associated with common carotid IMT in young adults, but the strength of the association is modified by other cardiovascular disease risk factors, such as body mass index. FVIII is associated with internal carotid IMT only in age-adjusted analyses, and no associations were observed for von Willebrand factor.
authors.affiliation: Division of Hematology/Oncology, Feinberg School of Medicine of Northwestern University, Chicago, Ill, USA. d-green@northwestern.edu
authors.forename: David
authors.initials: D
authors.lastname: Green
authors.forename: Nancy
authors.initials: N
authors.lastname: Foiles
authors.forename: Cheeling
authors.initials: C
authors.lastname: Chan
authors.forename: Joseph
authors.initials: J
authors.lastname: Kang
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Schreiner
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology*; D017536:Carotid Artery, Common / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D005167:Factor VII / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*; D055815:Young Adult
chemical_list: D005167:Factor VII
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