title: Fungal infections in transplant and oncology patients.
abstract: Recent shifts in the epidemiology of invasive fungal infections (IFIs) among transplant and oncology populations have led to new recommendations on treatment; however, they have also brought new controversies. New pharmacologic therapies are being studied and guidelines for management of several IFIs have been changed accordingly. More information is being discovered about unique genetic factors that put some transplant recipients at greater risk than others for fungal infection. The role of immunomodulation continues to be investigated, and the delicate balance of maintaining some immune integrity while assuring protection of the graft remains critical. For transplant and oncology patients, the diagnosis and management of IFIs remain challenging, and improving outcomes depends on continued progress in all of these arenas. This article highlights recent advances and important factors to consider when treating transplant and oncology patients with IFIs.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Duke University Health System, Duke University School of Medicine, Box 102359, Durham, NC 27710, USA. perso006@mc.duke.edu
authors.forename: Anna K
authors.initials: AK
authors.lastname: Person
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Alexander
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy*; D016377:Organ Transplantation / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents
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