Cystatin C, a novel urinary biomarker for sensitive detection of acute kidney injury during haemorrhagic fever with renal syndrome.
To explore the value of cystatin C for evaluating acute kidney injury (AKI) in haemorrhagic fever with renal syndrome (HFRS), the concentrations of cystatin C in serum and urine samples from HFRS patients were determined. The serum and urinary cystatin C concentrations significantly increased in HFRS patients compared with normal controls (p < 0.001). In the acute phase of HFRS, urinary cystatin C increased to higher levels than serum creatinine, especially in severe or critical cases in the oliguric stage. Furthermore, higher levels of urinary cystatin C in the acute phase positively correlated with increased severity of the subsequent kidney injury. In conclusion, urinary cystatin C is a more sensitive clinical marker for AKI in HFRS, which may enable us to initiate treatment measures as early as possible.
Ma
Ying
Y
Department of Immunology, The Fourth Military Medical University, Xi'an, China.
Li
Qi
Q
Wang
Jiuping
J
Xu
Zhuwei
Z
Song
Chaojun
C
Zhuang
Ran
R
Yang
Kun
K
Yang
Angang
A
Jin
Boquan
B
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine*; D002648:Child; D055316:Cystatin C / Q000097:blood / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000150:complications* / Q000652:urine; D006482:Hemorrhagic Fevers, Viral / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult
D015415:Biomarkers; D055316:Cystatin C