Normal movement selectivity in autism.
It has been proposed that individuals with autism have difficulties understanding the goals and intentions of others because of a fundamental dysfunction in the mirror neuron system. Here, however, we show that individuals with autism exhibited not only normal fMRI responses in mirror system areas during observation and execution of hand movements but also exhibited typical movement-selective adaptation (repetition suppression) when observing or executing the same movement repeatedly. Movement selectivity is a defining characteristic of neurons involved in movement perception, including mirror neurons, and, as such, these findings argue against a mirror system dysfunction in autism.
Dinstein
Ilan
I
Center for Neural Science, New York University, 6 Washington Place, New York, NY 10003, USA. ilan.dinstein@weizmann.ac.il
Thomas
Cibu
C
Humphreys
Kate
K
Minshew
Nancy
N
Behrmann
Marlene
M
Heeger
David J
DJ
D000328:Adult; D001321:Autistic Disorder / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007100:Imitative Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009039:Motion Perception; D009043:Motor Activity / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D014796:Visual Perception / Q000502:physiology
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