A new phosphonate pendant-armed cross-bridged tetraamine chelator accelerates copper(ii) binding for radiopharmaceutical applications.
A phosphonate pendant-armed cross-bridged cyclam chelator has been synthesized, complexed to Cu(ii), radiolabeled with (64)Cu under mild conditions, and its biodistribution studied.
Stigers
Dannon J
DJ
Department of Chemistry, University of New Hampshire, Durham, New Hampshire 03824, USA.
Ferdani
Riccardo
R
Weisman
Gary R
GR
Wong
Edward H
EH
Anderson
Carolyn J
CJ
Golen
James A
JA
Moore
Curtis
C
Rheingold
Arnold L
AL
D000588:Amines / Q000737:chemistry*; D001665:Binding Sites; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D013237:Stereoisomerism
D000588:Amines; D002614:Chelating Agents; D063065:Organophosphonates; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D003300:Copper