Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle.
The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A single nucleotide polymorphism in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds. Here, we report its allelic frequencies in Charolais and Beefmaster breeds; we confirm its association with three growth traits: weaning weight, weaning weight adjusted to 210 days and preweaning weight gain in the Charolais breed. In addition, we designed a strategy to search these breeds for new polymorphisms in four coding regions of the gene. A C/A transversion was detected in intron 4, but it was not associated with the growth traits. A single nucleotide polymorphism (IGF1/SnaBI) is proposed as a selection marker for Mexican Charolais cattle; validation of its association with weaning weight, weaning weight adjusted to 210 days and preweaning weight gain, could complement the genetic evaluations of this breed through marker-assisted management strategies.
Reyna
X F De la Rosa
XF
Instituto Politécnico Nacional, Centro de Biotecnología Genómica, Reynosa, Tamaulipas, México. xdelarosa@ipn.mx
Montoya
H M
HM
Castrellón
V V
VV
Rincón
A M S
AM
Bracamonte
M P
MP
Vera
W A
WA
D000483:Alleles; D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D001835:Body Weight; D001947:Breeding; D002417:Cattle; D005260:Female; D005787:Gene Frequency; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008800:Mexico; D011110:Polymorphism, Genetic; D013045:Species Specificity; D015430:Weight Gain / Q000235:genetics
D007334:Insulin-Like Growth Factor I