Identification of atypical scrapie in Canadian sheep.
Scrapie, a transmissible spongiform encephalopathy of sheep and goats, exists in most small ruminant-producing countries of the world. A novel form of this disease was recently recognized and is known by various names, including Nor98, Nor98-like, and atypical scrapie. Differing from classic scrapie in epidemiology, histopathology, and biochemical characteristics, atypical scrapie cases have been identified throughout Europe and in the United States. Enhanced scrapie surveillance efforts recently identified 3 cases of atypical scrapie in Canada.
Mitchell
Gordon B
GB
Canadian Food Inspection Agency, Ottawa Laboratory-Fallowfield, 3851 Fallowfield Road, Ottawa, Ontario, Canada, K2H 8P9.
O'Rourke
Katherine I
KI
Harrington
Noel P
NP
Soutyrine
Andrei
A
Simmons
Marion M
MM
Dudas
Sandor
S
Zhuang
Dongyue
D
Laude
Hubert
H
Balachandran
Aru
A
D000818:Animals; D015153:Blotting, Western; D002170:Canada / Q000453:epidemiology; D003062:Codon / Q000235:genetics; D015511:Goat Diseases / Q000453:epidemiology / Q000821:virology; D006041:Goats; D015151:Immunoblotting / Q000379:methods; D018620:PrPSc Proteins / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D017096:Prion Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D011328:Prions / Q000235:genetics / Q000472:pathogenicity; D012608:Scrapie / Q000453:epidemiology*; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000821:virology; D014481:United States
D003062:Codon; D018620:PrPSc Proteins; D011328:Prions