title: Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom.
abstract: We assessed the relationship between strain type, clinical factors, and outcome in 128 patients with Clostridium difficile infection. Strain type was not associated with any outcome measure. On multivariate analysis, ischemic heart disease and hypoalbuminemia predicted death. Metronidazole treatment in severe disease was associated with a higher rate of treatment failure and death.
authors.affiliation: Department of Microbiology and Infection, Brighton and Sussex University Hospitals National Health Service Trust, UK.
authors.forename: Vhairi
authors.initials: V
authors.lastname: Wilson
authors.forename: Liz
authors.initials: L
authors.lastname: Cheek
authors.forename: Giovanni
authors.initials: G
authors.lastname: Satta
authors.forename: Karen
authors.initials: K
authors.lastname: Walker-Bone
authors.forename: Marc
authors.initials: M
authors.lastname: Cubbon
authors.forename: Diane
authors.initials: D
authors.lastname: Citron
authors.forename: Dale N
authors.initials: DN
authors.lastname: Gerding
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Llewelyn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects; D016360:Clostridioides difficile / Q000145:classification*; D003015:Clostridium Infections / Q000382:microbiology / Q000401:mortality*; D005243:Feces / Q000382:microbiology; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole