RAAS blockade in combination with diuretic therapy increases urine excretion, which in turn increases drinking and thus reduces erythropoietin and proteinuria.
Thornton
Simon N
SN
D002908:Chronic Disease; D004232:Diuretics / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000097:blood*; D006438:Hemodilution; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007674:Kidney Diseases / Q000378:metabolism*; D019808:Losartan / Q000494:pharmacology*; D011507:Proteinuria / Q000378:metabolism / Q000517:prevention & control*; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D014554:Urination / Q000187:drug effects*
D004232:Diuretics; D006454:Hemoglobins; D006852:Hydrochlorothiazide; D004921:Erythropoietin; D019808:Losartan