title: Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.
abstract: OBJECTIVE
  Genetic factors are believed to contribute to the development and progression of diabetic nephropathy. Recently, a genome-wide association study for diabetic nephropathy revealed four novel candidate loci in European American subjects with type 1 diabetes. In this study, we determined the association of the four loci with diabetic nephropathy in Japanese subjects with type 2 diabetes.
  
  
  METHODS
  We genotyped 11 singlenucleotide polymorphisms (SNPs) in four distinct loci (rs39059 and rs39075 in the CPVL/CHN2, rs1888747 and rs10868025 in FRMD3, rs739401 and rs451041 in CARS, and rs1041466, rs1411766, rs6492208, rs7989848, and rs9521445 in a chromosome 13q locus) in four independent Japanese populations.
  
  
  RESULTS
  Six SNPs were nominally associated with diabetic nephropathy in one of the four Japanese populations (P < 0.05; rs451041 in study 1; rs39059 and rs1888747 in study 3; rs1411766 in studies 1 and 4; and rs7989848 and rs9521445 in study 4); however, no significant association was observed for any SNP after correction for multiple testing errors in the individual populations. Nevertheless, a meta-analysis performed for the data obtained from all four populations revealed that one SNP (rs1411766) in chromosome 13q was significantly associated with diabetic nephropathy in the Japanese populations (nominal P = 0.004, corrected P = 0.04, odds ratio 1.26 [95% CI = 1.07-1.47]).
  
  
  CONCLUSIONS
  Our results suggest that the rs1411766 locus may be commonly involved in conferring susceptibility to diabetic nephropathy among subjects with type 1 or type 2 diabetes across different ethnic groups.
authors.affiliation: Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Japan. smaeda@src.riken.jp
authors.forename: Shiro
authors.initials: S
authors.lastname: Maeda
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Araki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Babazono
authors.forename: Masao
authors.initials: M
authors.lastname: Toyoda
authors.forename: Tomoya
authors.initials: T
authors.lastname: Umezono
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Masahito
authors.initials: M
authors.lastname: Imanishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Uzu
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Watada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Suzuki
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Kaku
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamori
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D044466:Asian People / Q000235:genetics; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005060:Europe / Q000208:ethnology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007564:Japan / Q000208:ethnology; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: D004247:DNA
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