[Characterization of vaccine polioviruses isolated in the closed pediatric collective bodies (children's homes)].
Examination of 281 healthy vaccinees from 6 children's homes could isolate 37 vaccine polioviruses. The detection rate for polioviruses in the children's homes, in which there were children born to HIV-positive mothers, was significantly higher than that in other children's homes. These children's homes showed the longest poliovirus excretion after vaccination. The RFLP analysis showed that 40% of the strains being examined were intertypic recombinant strains. The sequence analysis demonstrated that about 30% of the strains under study had a small number of nucleotide substitutions in the VP3-VP1 genomic region. The study revealed a correlation between the dynamics of poliovirus excretion after oral vaccination and the kinetics of formation of recombinant poliovirus strains.
Romanenkova
N I
NI
Bichurina
M A
MA
Rozaeva
N R
NR
D002353:Carrier State / Q000175:diagnosis* / Q000821:virology; D002648:Child; D002674:Child, Institutionalized; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D011051:Poliomyelitis / Q000517:prevention & control* / Q000821:virology; D017955:Poliovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D011995:Recombination, Genetic; D012426:Russia; D014611:Vaccination; D014774:Virulence
D011055:Poliovirus Vaccine, Oral