title: Traditional Chinese medicine and related active compounds against hepatitis B virus infection.
abstract: Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China and widely used for hepatitis B in China and many parts of the world. Many TCMs and related active compounds have been reported that have promising and potent anti-HBV activities, including Phyllanthus, Salvia miltiorrhiza, Rheum palmatum L., Radix Astragali, oxymatrine, artemisinin and artesunate, and wogonin. Thus, TCM is a potential candidate for anti-HBV drugs. More information is needed regarding TCMs, including preparation, standardization, identification of active ingredients, and toxicological evaluation. Therefore, TCM development needs to apply advanced and interdisciplinary methodology and technology and perform further rigorously designed experimental and clinical investigations.
authors.affiliation: Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Cui
authors.forename: Yueling
authors.initials: Y
authors.lastname: Wang
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kokudo
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Fang
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology; D000077332:Artesunate; D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry; D008517:Phytotherapy / Q000379:methods*; D011807:Quinolizines / Q000737:chemistry / Q000494:pharmacology; D012250:Rheum / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D037621:Artemisinins; D000077332:Artesunate; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines; C027492:Huang Qi; C031327:artemisinin; C085514:wogonin