title: Asymmetric deprotonation of N-boc piperidine: react IR monitoring and mechanistic aspects.
abstract: The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the lithiation by in situ React IR allowed the direct observation of a prelithiation complex.
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Darren
authors.initials: D
authors.lastname: Stead
authors.forename: Giorgio
authors.initials: G
authors.lastname: Carbone
authors.forename: Peter
authors.initials: P
authors.lastname: O'Brien
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Campos
authors.forename: Iain
authors.initials: I
authors.lastname: Coldham
authors.forename: Adam
authors.initials: A
authors.lastname: Sanderson
mesh_terms: D010880:Piperidines / Q000737:chemistry*; D011522:Protons; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
chemical_list: C454939:N-(tert-butoxycarbonyl)piperidine; D010880:Piperidines; D011522:Protons