Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype.
BACKGROUND
Sex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men. The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women.


OBJECTIVE
Our objective was to evaluate the effect of endogenous sex hormones on very-low-density lipoprotein (VLDL) triglyceride (TG) and apolipoprotein B-100 (apoB-100) metabolism. EXPERIMENTAL DESIGN AND MAIN OUTCOME MEASURES: We measured basal VLDL-TG and VLDL-apoB-100 concentrations and kinetics by using stable isotope-labeled tracers.


METHODS
Eight premenopausal women [age, 43 + or - 8 yr; body mass index (BMI), 35 + or - 4 kg/m(2); mean + or - sd], eight postmenopausal women (age, 55 + or - 4 yr; BMI, 34 + or - 4 kg/m(2)), and eight men (age, 41 + or - 13 yr; BMI, 34 + or - 4 kg/m(2)) were studied at Washington University School of Medicine, St. Louis, MO.


RESULTS
VLDL-TG secretion rate was approximately double (P < 0.05) in postmenopausal women and men compared with premenopausal women but not different in postmenopausal women and men. The secretion rate of VLDL-apoB-100 was not different in pre- and postmenopausal women but was greater (P < 0.05) in men than in women.


CONCLUSIONS
Endogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones.
Magkos
Faidon
F
Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA.
Fabbrini
Elisa
E
Mohammed
B Selma
BS
Patterson
Bruce W
BW
Klein
Samuel
S
Mittendorfer
Bettina
B
D000328:Adult; D000704:Analysis of Variance; D053299:Apolipoprotein B-100 / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000172:deficiency* / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D017697:Premenopause / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D012737:Sex Factors; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000378:metabolism
D053299:Apolipoprotein B-100; D004967:Estrogens; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone
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