title: Assessing medication adherence of perinatally HIV-infected children using caregiver interviews.
abstract: Medication adherence is critical for children's HIV treatment success, but obtaining accurate assessments is challenging when complex measurement technologies are not feasible. Our goal was to evaluate a multidimensional adherence interview designed to improve on existing adherence measures. Data from caregivers (N = 126) of perinatally infected children were analyzed to determine the ability of the revised interview guide to detect potential treatment nonadherence. Questions related to viral load (VL) on a bivariate level included proportion of doses taken in the previous 3 days and 6 months, caregivers' knowledge of prescribed dosing frequencies, and caregivers' reports of problems associated with medication administration. VL was not associated with 3-day recall of missed doses. In multivariate analyses, only caregiver knowledge of prescribed dosing frequencies was uniquely associated with VL. Our modified interview appears to successfully identify family struggles with adherence and to have the capacity to help clinicians address medication adherence challenges.
authors.affiliation: School of Medicine, University of Maryland, Baltimore, MD, USA.
authors.forename: Susannah M
authors.initials: SM
authors.lastname: Allison
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Koenig
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Marhefka
authors.forename: Rosalind J
authors.initials: RJ
authors.lastname: Carter
authors.forename: Elaine J
authors.initials: EJ
authors.lastname: Abrams
authors.forename: Marc
authors.initials: M
authors.lastname: Bulterys
authors.forename: Vicki
authors.initials: V
authors.lastname: Tepper
authors.forename: Paul E
authors.initials: PE
authors.lastname: Palumbo
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Bachanas
authors.forename: John J
authors.initials: JJ
authors.lastname: Farley
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D017028:Caregivers; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D015999:Multivariate Analysis; D010349:Patient Compliance; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents
references.citation: AIDS Behav. 2005 Sep;9(3):355-62
references.pmid: 16088365
references.citation: J Acquir Immune Defic Syndr. 2006 Mar;41(3):315-22
references.pmid: 16540932
references.citation: Pediatr Infect Dis J. 2000 Dec;19(12):1148-53
references.pmid: 11144374
references.citation: AIDS Care. 2000 Jun;12(3):255-66
references.pmid: 10928201
references.citation: AIDS Care. 2001 Oct;13(5):617-29
references.pmid: 11571008
references.citation: Paediatr Perinat Epidemiol. 2006 Jul;20(4):338-47
references.pmid: 16879506
references.citation: Pediatr Infect Dis J. 2003 Jan;22(1):56-62
references.pmid: 12544410
references.citation: N Engl J Med. 2001 Nov 22;345(21):1522-8
references.pmid: 11794218
references.citation: AIDS Behav. 2006 May;10(3):227-45
references.pmid: 16783535
references.citation: Clin Infect Dis. 2002 Apr 15;34(8):1115-21
references.pmid: 11915001
references.citation: Pediatrics. 2006 Dec;118(6):e1745-57
references.pmid: 17101712
references.citation: Pediatr Infect Dis J. 2007 Jan;26(1):61-7
references.pmid: 17195708
references.citation: Pediatrics. 2007 Jun;119(6):e1371-83
references.pmid: 17533177
references.citation: J Infect Dis. 2005 Feb 1;191(3):339-47
references.pmid: 15633092
references.citation: AIDS Care. 2004 Apr;16(3):323-38
references.pmid: 15203426
references.citation: J Acquir Immune Defic Syndr. 2003 Jun 1;33(2):211-8
references.pmid: 12794557
references.citation: AIDS Patient Care STDS. 2008 Aug;22(8):637-47
references.pmid: 18627275
references.citation: AIDS. 1998 Feb 12;12(3):301-8
references.pmid: 9517993
references.citation: Pediatrics. 2002 Apr;109(4):e61
references.pmid: 11927734
references.citation: JAMA. 1999 Aug 11;282(6):531-8
references.pmid: 10450714
references.citation: J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):187-93
references.pmid: 17693883