title: New technology for rapid molecular diagnosis of bloodstream infections.
abstract: Technologies for the correct and timely diagnosis of bloodstream infections are urgently needed. Molecular diagnostic methods have yet to have a major impact on the diagnosis of bloodstream infections; however, new methods are being developed that are beginning to address key issues. In this article, we discuss the key needs and objectives of molecular diagnostics for bloodstream infections and review some of the currently available methods and how these techniques meet key needs. We then focus on a new method that combines nucleic acid amplification with mass spectrometry in a novel approach to molecular diagnosis of bloodstream infections.
authors.affiliation: Ibis Biosciences, a subsidiary of Abbott Molecular, Inc., 2251 Faraday Ave, Carlsbad, CA 92008, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Ecker
authors.forename: Rangarajan
authors.initials: R
authors.lastname: Sampath
authors.forename: Haijing
authors.initials: H
authors.lastname: Li
authors.forename: Christian
authors.initials: C
authors.lastname: Massire
authors.forename: Heather E
authors.initials: HE
authors.lastname: Matthews
authors.forename: Donna
authors.initials: D
authors.lastname: Toleno
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Hall
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Blyn
authors.forename: Mark W
authors.initials: MW
authors.lastname: Eshoo
authors.forename: Raymond
authors.initials: R
authors.lastname: Ranken
authors.forename: Steven A
authors.initials: SA
authors.lastname: Hofstadler
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Tang
mesh_terms: D000368:Aged; D016470:Bacteremia / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000097:blood*; D004271:DNA, Fungal / Q000097:blood*; D005260:Female; D016469:Fungemia / Q000175:diagnosis*; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation / Q000379:methods; D021141:Nucleic Acid Amplification Techniques; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D055815:Young Adult
chemical_list: D004269:DNA, Bacterial; D004271:DNA, Fungal