Autoantibodies as prognostic markers in autoimmune liver disease.
Certain autoantibodies in autoimmune liver disease have prognostic implications that are under-utilized and under-developed. The goals of this review are to indicate progress in characterizing the autoantibodies with prognostic connotations and to indicate the feasibility and importance of discovering other markers. Prime source and review articles in English were selected by a Medline search through 2010. Antibodies to soluble liver antigen, actin, liver cytosol type 1, asialoglycoprotein receptor, chromatin, cyclic citrullinated peptide, and uridine glucuronosyltransferases have been associated with the occurrence, severity, and progression of autoimmune hepatitis, and antibodies to Sp100, gp210, and centromere have had similar implications in primary biliary cirrhosis. Antibodies to soluble liver antigen have shown the most promise in autoimmune hepatitis as they have been associated with severe histological changes, long durations of treatment, relapse after drug withdrawal, and high frequency of liver failure. Antibodies to the nuclear rim pore protein, gp210, have shown the most promise in primary biliary cirrhosis as they have been associated with severe interface hepatitis, lobular inflammation, and progression to liver failure. The major limitations of the autoantibodies have been their lack of standardized assays, low negative predictabilities, and fluctuating levels. Performance parameters will improve as critical pathogenic pathways, comprehensive testing batteries, and standardized assays through international exchange workshops are developed. Progress has been made in identifying the serological markers of prognosis in autoimmune liver disease, and they promise to reflect critical disease mechanisms and enhance patient management.
Czaja
Albert J
AJ
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. czaja.albert@mayo.edu
D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D019693:Hepatitis, Autoimmune / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007124:Immunoenzyme Techniques
D001323:Autoantibodies; D015415:Biomarkers
J Hepatol. 2004 Jun;40(6):904-9
15158329
Histochem Cell Biol. 1997 Jan;107(1):1-10
9049636
Hepatology. 2009 Jul;50(1):291-308
19554543
Clin Gastroenterol Hepatol. 2004 Sep;2(9):825-30
15354284
N Engl J Med. 1989 May 25;320(21):1377-80
2716784
Clin Gastroenterol Hepatol. 2008 Apr;6(4):379-88
18328791
Ann N Y Acad Sci. 2005 Jun;1050:266-73
16014542
Can J Gastroenterol. 2000 May;14(5):429-39
10851284
Gastroenterology. 1995 Feb;108(2):455-62
7835588
Clin Chim Acta. 2004 Dec;350(1-2):17-34
15530456
J Rheumatol. 2009 Oct;36(10):2250-6
19723904
J Hepatol. 1993 Aug;19(1):55-63
8301043
Autoimmunity. 2002 Dec;35(8):497-500
12765475
J Autoimmun. 1994 Feb;7(1):107-18
8198697
Liver Transpl. 2002 Jun;8(6):505-13
12037780
Hepatology. 1995 Jan;21(1):58-62
7806169
J Gastroenterol Hepatol. 1998 May;13(5):483-9
9641645
Gastroenterology. 1984 Oct;87(4):763-9
6088350
Pathology. 2009;41(6):572-5
19900107
J Gastroenterol Hepatol. 1995 Jul-Aug;10(4):438-45
8527711
Hepatology. 1987 Nov-Dec;7(6):1333-9
3679093
Liver. 2001 Aug;21(4):225-32
11454184
Hepatol Res. 2007 Oct;37 Suppl 3:S412-9
17931196
Hepatol Res. 2007 Oct;37 Suppl 3:S406-11
17931195
World J Gastroenterol. 2008 Jun 7;14(21):3306-12
18528928
Scand J Gastroenterol. 1991 Jul;26(7):707-13
1896812
Hepatology. 2001 Mar;33(3):591-6
11230739
Dig Dis Sci. 1998 Jun;43(6):1322-31
9635626
Clin Rev Allergy Immunol. 2008 Jun;34(3):321-5
18197482
Ann Rheum Dis. 1982 Dec;41(6):612-4
7149799
J Immunol Methods. 1990 Jun 12;130(1):1-8
2193058
Gastroenterology. 2008 Dec;135(6):2107-18
18773898
Dig Dis Sci. 2009 Feb;54(2):360-8
18629643
Ital J Pediatr. 2009 Jul 20;35(1):22
19712439
Clin Exp Immunol. 1987 Apr;68(1):108-16
3308206
Autoimmun Rev. 2002 Dec;1(6):321-8
12848987
Acta Virol. 2001 Feb;45(1):7-11
11394582
Autoimmunity. 2004 May;37(3):195-201
15497452
Hepatology. 2001 Sep;34(3):494-501
11526534
Toxicol Appl Pharmacol. 2008 Oct 15;232(2):280-91
18708081
Biomed Pharmacother. 1995;49(7-8):344-9
8562861
Expert Rev Gastroenterol Hepatol. 2007 Oct;1(1):113-28
19072440
J Cell Biol. 1990 Oct;111(4):1409-18
2211817
Scand J Immunol. 1995 Aug;42(2):257-68
7631159
Clin Exp Immunol. 1976 May;24(2):266-72
945140
Gastroenterology. 1994 Jan;106(1):193-9
8276182
Am J Gastroenterol. 2006 Dec;101(12):2731-6
17227520
Curr Opin Rheumatol. 2000 Sep;12(5):369-73
10990171
Clin Exp Immunol. 1998 Sep;113(3):339-45
9737660
J Immunol Methods. 2005 Jun;301(1-2):1-10
15890353
J Hepatol. 2004 Oct;41(4):677-83
15464251
Gut. 1995 May;36(5):749-54
7797126
Br J Rheumatol. 1995 May;34(5):407-12
7788167
J Rheumatol. 2005 Feb;32(2):231-8
15693082
Gastroenterology. 1997 Jun;112(6):2028-35
9178696
Gut. 1989 Apr;30(4):515-9
2714684
Clin Exp Dermatol. 1994 Jul;19(4):298-302
7955469
J Autoimmun. 2010 Feb;34(1):7-14
19766456
J Clin Immunol. 2006 Nov;26(6):495-505
17001515
J Immunol Methods. 1995 Dec 1;187(2):259-64
7499885
Hepatology. 1996 Nov;24(5):1068-73
8903377
Clin Immunol Immunopathol. 1989 Apr;51(1):77-82
2784364
Semin Liver Dis. 1997 Feb;17(1):79-90
9089913
J Immunol. 1989 Jun 1;142(11):3815-20
2715637
Mol Biol Rep. 1996;23(3-4):235-42
9112234
Arthritis Res Ther. 2005;7(5):R949-58
16207336
Dig Liver Dis. 2003 Nov;35(11):801-5
14674671
Gastroenterology. 1994 Sep;107(3):799-804
8076767
Arthritis Rheum. 1994 Nov;37(11):1684-8
7980678
Acta Med Okayama. 2002 Apr;56(2):99-105
12002624
J Immunol. 1990 Dec 15;145(12):4338-47
2258622
Clin Chim Acta. 2009 Oct;408(1-2):19-24
19576873
Aliment Pharmacol Ther. 2007 Sep 15;26(6):831-8
17767467
Drug Metab Dispos. 2009 Aug;37(8):1759-68
19439486
Autoimmun Rev. 2004 Jan;3(1):1-9
14871643
Arthritis Rheum. 2003 Oct;48(10):2741-9
14558078
Clin Exp Med. 2008 Mar;8(1):9-15
18385935
Am J Gastroenterol. 2010 Jan;105(1):125-31
19861957
Gastroenterology. 2003 Jun;124(7):1915-25
12806624
Hepatology. 1997 Sep;26(3):567-72
9303484
Hepatology. 1997 Mar;25(3):541-7
9049195
Hepatology. 2008 Mar;47(3):786-8
18302295
J Exp Med. 1990 Sep 1;172(3):961-7
2167346
J Autoimmun. 2001 Nov;17(3):223-8
11712860
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8531-4
2847165
Clin Exp Immunol. 2000 Aug;121(2):364-74
10931155
J Autoimmun. 2003 Jun;20(4):333-44
12791319
Hepatology. 1990 Dec;12(6):1314-20
2258147
Arthritis Res Ther. 2005;7(3):R458-67
15899032
Gastroenterology. 1987 Feb;92(2):304-8
3491773
Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 1):245-54
8811044
Clin Gastroenterol Hepatol. 2004 Dec;2(12):1116-22
15625657
Am J Gastroenterol. 1999 Jul;94(7):1906-13
10406258
Hepatology. 1997 Oct;26(4):1054-66
9328334
Transl Res. 2007 Mar;149(3):107-13
17320796
Dig Dis Sci. 2003 Aug;48(8):1658-64
12924665
Clin Exp Immunol. 1984 Feb;55(2):347-54
6199139
World J Gastroenterol. 2005 Mar 28;11(12):1862-6
15793882
Science. 1995 Dec 8;270(5242):1591-4
7502067
J Clin Pathol. 1976 May;29(5):403-10
777046
Semin Liver Dis. 2009 Aug;29(3):241-53
19675997
Hepatology. 1997 Feb;25(2):317-23
9021941
Hepatology. 1998 Aug;28(2):332-40
9695994
Scand J Gastroenterol. 2003 Sep;38(9):996-9
14531539
Ann N Y Acad Sci. 2007 Aug;1109:203-11
17785307
J Clin Lab Anal. 2007;21(4):249-53
17621360
J Rheumatol. 2005 Aug;32(8):1488-94
16078324
Cell Transplant. 2002;11(5):407-15
12382666
J Clin Invest. 1990 Jul;86(1):279-85
2195063
Drug Metab Pharmacokinet. 2007 Oct;22(5):367-76
17965520
Hepatology. 1988 Nov-Dec;8(6):1662-6
3192182
Hepatology. 2007 Jan;45(1):118-27
17187436
Biotechnol Lett. 2006 Jul;28(14):1061-9
16799763
Gastroenterology. 1984 Jan;86(1):142-9
6315523
J Clin Lab Anal. 2008;22(5):340-5
18803268
Gastroenterology. 1995 Apr;108(4):1124-35
7698580
Hepatology. 1997 Mar;25(3):689-96
9049220
Autoimmunity. 2004 Sep-Nov;37(6-7):473-80
15621574
Semin Liver Dis. 2005 Aug;25(3):298-310
16143945
Autoimmun Rev. 2009 Jul;8(8):713-6
19232552
Clin Exp Immunol. 2004 Jan;135(1):154-8
14678277
J Hepatol. 1995;22(1 Suppl):132-5
7602065
Am J Gastroenterol. 2003 Feb;98(2):431-7
12591064
Clin Exp Immunol. 1984 Mar;55(3):561-70
6368059
Semin Liver Dis. 1991 Aug;11(3):215-22
1925646
Exp Cell Res. 2004 Jan 15;292(2):332-41
14697341
J Autoimmun. 2004 Mar;22(2):159-66
14987745
J Hepatol. 1999 Mar;30(3):394-401
10190720
J Gastroenterol Hepatol. 2000 Oct;15(10):1176-82
11106099
J Exp Med. 1993 May 1;177(5):1367-81
8478612
Clin Exp Immunol. 1990 Aug;81(2):244-9
2117509
Hepatology. 1997 Nov;26(5):1123-30
9362351
Gut. 1998 May;42(5):721-6
9659171
J Clin Pathol. 2006 Mar;59(3):280-4
16505279
Hepatology. 2002 Feb;35(2):403-8
11826415
J Clin Gastroenterol. 2008 Oct;42(9):1047-53
18719506
J Clin Gastroenterol. 2008 Sep;42(8):926-30
18645526
Scand J Immunol. 1992 Oct;36(4):555-64
1384113
Am J Gastroenterol. 1995 Aug;90(8):1206-11
7639216
Clin Gastroenterol Hepatol. 2009 Dec;7(12):1355-60
19631286
Immunol Res. 1991;10(3-4):497-502
1955777
J Hepatol. 1986;3(2):196-205
3794301
J Hepatol. 1998 May;28(5):824-8
9625318
Z Gastroenterol. 1997 Jan;35(1):15-21
9123953
Autoimmun Rev. 2003 Jun;2(4):211-7
12848948
Liver Int. 2004 Aug;24(4):322-9
15287855
Lancet. 1984 Oct 27;2(8409):954-6
6149344
Dig Dis Sci. 2010 Oct;55(10):2712-26
20108036
Autoimmunity. 2008 Feb;41(1):105-10
18176872
Dig Dis Sci. 2007 Jan;52(1):179-84
17160474
Eur J Immunol. 2003 Jul;33(7):1869-78
12811847
Am J Gastroenterol. 2001 Mar;96(3):910-1
11280576
Hepatology. 2004 May;39(5):1398-407
15122769
Bioessays. 2003 Nov;25(11):1106-18
14579251
Z Gastroenterol. 1997 Feb;35(2):113-21
9066101
Lancet. 1994 Aug 27;344(8922):578-81
7914961
Hepatology. 1990 Apr;11(4):606-12
1691732
Gastroenterology. 1999 Mar;116(3):643-9
10029623
Arthritis Rheum. 2000 Aug;43(8):1831-5
10943873
J Immunol Methods. 2008 Sep 30;338(1-2):63-6
18691595
Gastroenterology. 1994 Jul;107(1):200-7
8020663
Hepatology. 1990 Mar;11(3):408-15
2312054
J Hepatol. 1995 Jul;23(1):32-8
8530807
Adv Clin Chem. 2005;40:127-64
16355922
Braz J Med Biol Res. 2002 May;35(5):499-507
12011934
Aliment Pharmacol Ther. 2005 Nov 15;22(10):951-5
16268969
J Cell Physiol. 1992 Feb;150(2):344-52
1346401
J Biol Chem. 2000 Nov 17;275(46):36164-71
10748067
Mod Rheumatol. 2007;17(6):486-91
18084701
Hepatology. 1992 Oct;16(4):892-8
1398495
Autoimmunity. 2006 Jun;39(4):341-8
16891223
Eur J Gastroenterol Hepatol. 2002 Jan;14(1):35-42
11782573
J Pediatr Gastroenterol Nutr. 1993 Nov;17(4):376-81
8145091
Gastroenterology. 1996 Dec;111(6):1576-86
8942737
Mol Pharmacol. 1996 Aug;50(2):326-33
8700140
J Gastroenterol Hepatol. 1990 May-Jun;5(3):244-51
2103405
Dig Dis Sci. 1996 Sep;41(9):1733-40
8794787
Am J Gastroenterol. 1997 Dec;92(12):2197-200
9399751
Eur J Pediatr. 2000 May;159(5):310-3
10834513
Hepatology. 1996 Jan;23(1):57-61
8550049
Autoimmunity. 2004 Jun;37(4):295-9
15518045
Gastroenterology. 1992 Oct;103(4):1290-5
1397887
Clin Exp Immunol. 1992 Apr;88(1):45-9
1532926
Am J Gastroenterol. 2001 Apr;96(4):1224-31
11316174
Hepatology. 1991 Dec;14(6):1070-5
1959856
J Clin Invest. 1994 Jul;94(1):184-92
8040259
Clin Exp Immunol. 2002 Jan;127(1):172-5
11882049