title: [Research on conventional and molecular epidemiology of tuberculosis in Orizaba, Veracruz, 1995-2008].
abstract: This study describes the achievements of the Mexican Consortium against Tuberculosis, in the Sanitary District of Orizaba, Veracruz, Mexico between 1995 and 2008. In brief, the main results can be classified as follows: 1) Conventional and molecular epidemiology (measurement of burden of disease, trends, risk factors and vulnerable groups, consequences of drug resistance, identification of factors that favor nosocomial and community transmission); 2) Development of diagnostic techniques to detect drug resistance, description of circulating clones and adaptation of simple techniques to be used in the field; 3) Evaluation of usefulness of tuberculin skin test, immunologic responses to BCG, impact of directly observed therapy for tuberculosis (DOTS), and study of immunological biomarkers and 4) Comments on ethical aspects of tuberculosis research. Additionally, we describe the impact on public policies, transference of technology, capacity building and future perspectives.
authors.affiliation: Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
authors.forename: Ma Eugenia
authors.initials: ME
authors.lastname: Jiménez-Corona
authors.forename: Lourdes
authors.initials: L
authors.lastname: García-García
authors.forename: Alfredo Ponce de
authors.initials: AP
authors.lastname: León
authors.forename: Miriam
authors.initials: M
authors.lastname: Bobadilla-del Valle
authors.forename: Martha
authors.initials: M
authors.lastname: Torres
authors.forename: Sergio
authors.initials: S
authors.lastname: Canizales-Quintero
authors.forename: Carmen
authors.initials: C
authors.lastname: Palacios-Merino
authors.forename: Susana
authors.initials: S
authors.lastname: Molina-Hernández
authors.forename: Rosa Areli
authors.initials: RA
authors.lastname: Martínez-Gamboa
authors.forename: Luis
authors.initials: L
authors.lastname: Juárez-Sandino
authors.forename: Bulmaro
authors.initials: B
authors.lastname: Cano-Arellano
authors.forename: Leticia
authors.initials: L
authors.lastname: Ferreyra-Reyes
authors.forename: Luis Pablo
authors.initials: LP
authors.lastname: Cruz-Hervert
authors.forename: Renata
authors.initials: R
authors.lastname: Báez-Saldaña
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ferreira-Guerrero
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sada
authors.forename: Brenda
authors.initials: B
authors.lastname: Marquina
authors.forename: José
authors.initials: J
authors.lastname: Sifuentes-Osornio
mesh_terms: D006801:Humans; D008800:Mexico / Q000453:epidemiology; D017720:Molecular Epidemiology; D013997:Time Factors; D014376:Tuberculosis / Q000453:epidemiology*