title: Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells.
abstract: Mitochondria and plastids have their own DNAs and are regarded as descendants of endosymbiotic prokaryotes. Organellar DNAs are not naked in vivo but are associated with basic proteins to form DNA-protein complexes (called organelle nuclei). The concept of organelle nuclei provides a new approach to explain the origin, division, and inheritance of organelles. Organelles divide using organelle division rings (machineries) after organelle-nuclear division. Organelle division machineries are a chimera of the FtsZ (filamentous temperature sensitive Z) ring of bacterial origin and the eukaryotic mechanochemical dynamin ring. Thus, organelle division machineries contain a key to solve the origin of organelles (eukaryotes). The maternal inheritance of organelles developed during sexual reproduction and it is also probably intimately related to the origin of organelles. The aims of this review are to describe the strategies used to reveal the dynamics of organelle division machineries, and the significance of the division machineries and maternal inheritance in the origin and evolution of eukaryotes.
authors.affiliation: Research Information Center of Extremophile, Rikkyo (St. Paul's) University, Tokyo, Japan. tsune@rikkyo.ne.jp
authors.forename: Tsuneyoshi
authors.initials: T
authors.lastname: Kuroiwa
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000166:cytology* / Q000378:metabolism / Q000528:radiation effects; D018390:Gene Targeting; D016678:Genome / Q000235:genetics; D006801:Humans; D008027:Light; D008954:Models, Biological; D015388:Organelles / Q000235:genetics* / Q000378:metabolism* / Q000528:radiation effects; D012100:Reproduction, Asexual / Q000235:genetics
references.citation: Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1382-7
references.pmid: 16432229
references.citation: Nature. 1998 Nov 12;396(6707):133-40
references.pmid: 9823893
references.citation: Int Rev Cytol. 1995;161:49-110
references.pmid: 7558693
references.citation: J Cell Biol. 1977 Mar;72(3):687-94
references.pmid: 557040
references.citation: Curr Opin Plant Biol. 2008 Dec;11(6):577-84
references.pmid: 18990608
references.citation: Curr Biol. 2009 Sep 15;19(17):1491-7
references.pmid: 19699094
references.citation: Biochim Biophys Acta. 1998 May 27;1403(1):72-84
references.pmid: 9622597
references.citation: Plant Cell. 2001 Mar;13(3):707-21
references.pmid: 11251107
references.citation: Science. 2006 Sep 8;313(5792):1435-8
references.pmid: 16960006
references.citation: Nature. 2009 Mar 19;458(7236):357-61
references.pmid: 19295610
references.citation: Biochim Biophys Acta. 2006 May-Jun;1763(5-6):510-21
references.pmid: 16690143
references.citation: Nature. 2004 Apr 8;428(6983):653-7
references.pmid: 15071595
references.citation: J Cell Biol. 2000 Oct 16;151(2):F1-4
references.pmid: 11038192
references.citation: Mol Biol Cell. 2005 May;16(5):2493-502
references.pmid: 15772156
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):803-7
references.pmid: 19141634
references.citation: Annu Rev Cell Dev Biol. 1997;13:395-424
references.pmid: 9442879
references.citation: Int Rev Cell Mol Biol. 2008;271:97-152
references.pmid: 19081542
references.citation: J Cell Biol. 1974 Oct;63(1):299-306
references.pmid: 4138519
references.citation: BMC Biol. 2007 Jul 10;5:28
references.pmid: 17623057
references.citation: J Struct Funct Genomics. 2009 Apr;10(2):165-79
references.pmid: 19130299
references.citation: Plant Cell. 2003 Mar;15(3):655-65
references.pmid: 12615939
references.citation: Int Rev Cytol. 1998;181:1-41
references.pmid: 9522454
references.citation: Int Rev Cytol. 1982;75:1-59
references.pmid: 6179895
references.citation: Curr Genet. 1994 Apr;25(4):357-61
references.pmid: 8082179
references.citation: Genes Dev. 2002 May 1;16(9):1116-28
references.pmid: 12000794
references.citation: Nature. 1982 Jul 29;298(5873):481-3
references.pmid: 7088193
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12548-53
references.pmid: 19592510
references.citation: Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47
references.pmid: 15040446
references.citation: J Plant Res. 2010 Mar;123(2):207-30
references.pmid: 20145972
references.citation: Biophys J. 1999 Jul;77(1):604-16
references.pmid: 10388785
references.citation: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12577-82
references.pmid: 10535964
references.citation: Genetics. 2003 Jul;164(3):963-75
references.pmid: 12871907
references.citation: Science. 2001 Aug 24;293(5534):1480-3
references.pmid: 11520985
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4736-41
references.pmid: 17360593
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2146-51
references.pmid: 12566569
references.citation: Plant Cell. 2002 Jul;14(7):1579-89
references.pmid: 12119376
references.citation: Mol Biol Cell. 2003 Dec;14(12):4758-69
references.pmid: 12960433
references.citation: J Cell Biol. 1962 Jun;13:383-91
references.pmid: 14492436