title: Anti-fungal cell wall beta-glucan antibody in animal sera.
abstract: beta-Glucan is a major component of the cell walls and pathogen-associated microbial patterns of fungi. We previously reported the presence of an antibody which reacts to beta-glucan, anti-beta-glucan (BG) antibody, in human sera. In livestock and domestic pets, the antibody's response to fungal cell wall beta-glucan is little understood. In this study, we examined the existence and reactivity of anti-BG antibody in various animal species. We demonstrated the presence of the anti-BG antibody in each animal's serum. Individual differences in the titer existed. The antibody was highly reactive to Candida solubilized cell wall beta-glucan (CSBG) while reacting little to grifolan (GRN) from Grifola frondosa. This suggested that the anti-BG antibody interacted with fungal cell wall beta-glucan and participated in the immune-response to pathogenic fungi.
authors.affiliation: Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Chikaku
authors.initials: C
authors.lastname: Dogasaki
authors.forename: Masuro
authors.initials: M
authors.lastname: Motoi
authors.forename: Noriko
authors.initials: N
authors.lastname: Miura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Adachi
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohno
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood*; D000918:Antibody Specificity; D002417:Cattle; D002473:Cell Wall / Q000276:immunology*; D002645:Chickens; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D005658:Fungi / Q000166:cytology* / Q000276:immunology*; D006041:Goats; D006168:Guinea Pigs; D000882:Haplorhini; D006736:Horses; D056724:Immunity, Humoral; D009181:Mycoses / Q000276:immunology / Q000382:microbiology; D011817:Rabbits; D013552:Swine; D014421:Turkey; D047071:beta-Glucans / Q000276:immunology*
chemical_list: D000908:Antibodies, Fungal; D047071:beta-Glucans