title: Efficacy of prophylactic antibiotics for dental implants: a multicentre placebo-controlled randomised clinical trial.
abstract: OBJECTIVE
  To evaluate the efficacy of prophylactic antibiotics for dental implant placement.
  
  
  METHODS
  Twelve Italian private practices agreed to participate in this trial, each centre providing 30 patients. One hour prior to implant placement, patients were randomised, for consumption orally of 2 g amoxicillin or identical placebo tablets. Patients needing bone augmentation procedures were not included. Outcome measures were prosthesis and implant failures, adverse events and post-operative biological complications. Patients were seen 1 week, 2 weeks and 4 months post-operatively.
  
  
  RESULTS
  One centre did not deliver any data and 14 patients had to be excluded from the trial for various reasons. One hundred and fifty-eight patients were evaluated in each group and none dropped out at 4 months. Two prostheses and two implants failed in the antibiotics group, compared with four prostheses and nine implants in the placebo group. There were no statistically significant differences for prosthesis failures, implant losses, complications and side effects.
  
  
  CONCLUSIONS
  No statistically significant differences were observed. However, four times more patients in the placebo group experienced implant failures than in the antibiotic group, and this requires further investigation.
authors.affiliation: Oral and Maxillofacial Surgery, School of Denstistry, The University of Manchester, Manchester, UK. espositomarco@hotmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Esposito
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Cannizzaro
authors.forename: Paolo
authors.initials: P
authors.lastname: Bozzoli
authors.forename: Ugo
authors.initials: U
authors.lastname: Consolo
authors.forename: Pietro
authors.initials: P
authors.lastname: Felice
authors.forename: Vittorio
authors.initials: V
authors.lastname: Ferri
authors.forename: Stefano
authors.initials: S
authors.lastname: Landriani
authors.forename: Michele
authors.initials: M
authors.lastname: Leone
authors.forename: Antonio
authors.initials: A
authors.lastname: Magliano
authors.forename: Guiseppe
authors.initials: G
authors.lastname: Pellitteri
authors.forename: Marzio
authors.initials: M
authors.lastname: Todisco
authors.forename: Cinzia
authors.initials: C
authors.lastname: Torchio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D000044:Dental Abutments; D015921:Dental Implants; D019232:Dental Restoration Failure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D010919:Placebos; D011183:Postoperative Complications; D013529:Surgical Wound Dehiscence / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015921:Dental Implants; D010919:Placebos; D000658:Amoxicillin