title: Time course of coagulopathy in isolated severe traumatic brain injury.
abstract: BACKGROUND
  Time aspects of coagulopathy following severe traumatic brain injury (sTBI) are ill defined throughout the literature. Thus, the aim of this study was to evaluate the time course of coagulopathy following isolated sTBI and its relationship to in-hospital outcomes.
  
  
  METHODS
  Retrospective analysis of patients sustaining isolated sTBI (head AIS 3, extracranial injuries AIS < 3). TBI coagulopathy was defined as thrombocytopenia and/or elevated international normalised ratio (INR) and/or prolonged activated partial thromboplastin time (aPTT). Incidence, onset and duration of sTBI-coagulopathy and its impact on morbidity and mortality were analysed.
  
  
  RESULTS
  Overall, 45.7% (n = 127) of the 278 patients included developed coagulopathy. Coagulopathy occurred 23.1 ± 2.2 h [range: 0.1–108.2 h (0–4.5 days)] post-admission with a mean duration of 68.0 ± 7.4 h[range: 2.6–531.4 h (0.1–22.1 days)]. The time interval to onset of coagulopathy decreased significantly with increasing head injury severity (p = 0.015). Early coagulation abnormalities occurring within 12 h of admission along with markers of devastating head injury including head AIS 5, penetrating injury mechanism, subdural hematoma, and a low GCS on admission proved to be independent risk factors for mortality.
  
  
  CONCLUSIONS
  The sTBI-associated coagulopathy may ensue as late as 5 days after injury with a prolonged duration (>72 h) in 30% of patients. Early coagulopathy occurring within 12 h after injury is a marker of increased morbidity and poor outcomes. Pertinent prolonged screening of this sequela is warranted.
authors.affiliation: Department of Surgery, Division of Acute Care Surgery (Trauma, Emergency Surgery and Surgical Critical Care) at the Los Angeles County + University of Southern California MedicalCenter, Los Angeles, CA, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lustenberger
authors.forename: Peep
authors.initials: P
authors.lastname: Talving
authors.forename: Leslie
authors.initials: L
authors.lastname: Kobayashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Inaba
authors.forename: Lydia
authors.initials: L
authors.lastname: Lam
authors.forename: David
authors.initials: D
authors.lastname: Plurad
authors.forename: Demetrios
authors.initials: D
authors.lastname: Demetriades
mesh_terms: D001778:Blood Coagulation Disorders / Q000453:epidemiology / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors