Vital pulp therapy-current progress of dental pulp regeneration and revascularization.
Pulp vitality is extremely important for the tooth viability, since it provides nutrition and acts as biosensor to detect pathogenic stimuli. In the dental clinic, most dental pulp infections are irreversible due to its anatomical position and organization. It is difficult for the body to eliminate the infection, which subsequently persists and worsens. The widely used strategy currently in the clinic is to partly or fully remove the contaminated pulp tissue, and fill and seal the void space with synthetic material. Over time, the pulpless tooth, now lacking proper blood supply and nervous system, becomes more vulnerable to injury. Recently, potential for successful pulp regeneration and revascularization therapies is increasing due to accumulated knowledge of stem cells, especially dental pulp stem cells. This paper will review current progress and feasible strategies for dental pulp regeneration and revascularization.
Zhang
Weibo
W
Division of Craniofacial and Molecular Genetics, Department of Oral and Maxillofacial Pathology, Tufts University, 136 Harrison Avenue, Room M824, Boston, MA 02111, USA.
Yelick
Pamela C
PC
J Am Dent Assoc. 2000 Jun;131 Suppl:39S-46S
10860344
J Endod. 2008 Aug;34(8):962-9
18634928
J Dent Res. 2004 Jul;83(7):518-22
15218039
Arch Oral Biol. 2000 Feb;45(2):173-7
10716622
J Endod. 2006 Jan;32(1):34-8
16410065
Birth Defects Res C Embryo Today. 2004 Jun;72(2):200-12
15269893
Int Endod J. 2006 Apr;39(4):249-81
16584489
J Dent Res. 2002 Aug;81(8):531-5
12147742
J Oral Maxillofac Surg. 2008 Nov;66(11):2314-7
18940498
Proc Finn Dent Soc. 1992;88 Suppl 1:357-68
1508891
Microcirculation. 2006 Sep;13(6):423-37
16864410
J Endod. 2008 Feb;34(2):166-71
18215674
J Endod. 2008 Aug;34(8):919-25; Discussion 1157
18634921
J Oral Maxillofac Surg. 2009 Feb;67(2):335-47
19138608
Eur J Orthod. 1990 Feb;12(1):38-50
2318262
Tissue Eng Part A. 2008 Dec;14(12):2051-8
18636949
Cell Death Differ. 2007 Jun;14(6):1162-71
17347663
J Dent. 1997 Mar;25(2):97-105
9105139
J Dent Res. 1994 Sep;73(9):1515-22
7929986
J Endod. 2008 Nov;34(11):1302-1305
18928836
Cell. 2006 Aug 25;126(4):663-76
16904174
Tissue Eng Part A. 2008 Jul;14(7):1141-7
18593355
Pract Proced Aesthet Dent. 2009 Mar-Apr;21(2):81-9
19583165
J Dent Res. 2004 Aug;83(8):590-5
15271965
Connect Tissue Res. 2002;43(2-3):387-90
12489186
Stem Cells. 2008 Sep;26(9):2408-18
18583536
Tissue Eng Part A. 2008 Dec;14(12):2059-68
18939934
Int J Oral Maxillofac Implants. 2007 Nov-Dec;22(6):893-904
18271370
Stem Cells. 2006 Nov;24(11):2493-503
16873765
Biotechnol Prog. 1996 Nov-Dec;12(6):865-8
8983211
Int J Mol Med. 2008 May;21(5):539-44
18425344
Regen Med. 2009 May;4(3):377-85
19438313
Anat Rec (Hoboken). 2009 Apr;292(4):570-9
19226618
Gen Dent. 2006 Jan-Feb;54(1):37-40
16494119
Tissue Eng Part A. 2010 Feb;16(2):605-15
19737072
J Dent Res. 2004 Jul;83(7):523-8
15218040
J Endod. 2004 Apr;30(4):205-8
15085046
J Endod. 2008 Jun;34(6):645-51
18498881
Arch Oral Biol. 1990;35(9):707-15
2091590
J Hist Dent. 2008 Spring;56(1):9-23
18578224
Pediatr Dent. 2002 Jan-Feb;24(1):29-32
11874055
Eur J Oral Sci. 2000 Jun;108(3):202-6
10872990
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):435-40
19896887
Pediatr Dent. 2004 May-Jun;26(3):214-20
15185801
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12
12716973
J Dent Res. 2006 Sep;85(9):819-23
16931864
Cell Tissue Res. 2004 Mar;315(3):375-84
14740293
Gen Dent. 2002 May-Jun;50(3):252-6; quiz 257-8
12116513
Tissue Eng. 2005 Sep-Oct;11(9-10):1599-610
16259613
Nat Methods. 2007 Mar;4(3):227-30
17322892
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30
11087820
J Biomater Sci Polym Ed. 1998;9(7):749-64
9686338
J Dent Res. 2002 Oct;81(10):695-700
12351668
Tissue Eng. 2006 Oct;12(10):2813-23
17518650
Science. 1993 May 14;260(5110):920-6
8493529
Hum Gene Ther. 2003 Apr 10;14(6):591-7
12718768
Hum Gene Ther. 2004 Nov;15(11):1045-53
15610605
Nature. 2008 May 15;453(7193):330-7
18480814
J Esthet Restor Dent. 2006;18(5):280-300
16987326
J Endod. 2008 Apr;34(4):421-6
18358888
J Am Dent Assoc. 2008 Apr;139(4):457-65
18385030
Stem Cells Dev. 2008 Jun;17(3):475-82
18513162
J Dent. 2000 Feb;28(2):77-92
10666965
Biomaterials. 2006 Jun;27(17):3238-48
16504285
Acta Odontol Scand. 1999 Apr;57(2):87-92
10445361
Int Endod J. 2008 Aug;41(8):664-9
18479368
Clin Oral Implants Res. 2009 Mar;20(3):254-61
19397637
J Endod. 2003 Oct;29(10):646-50
14606787
Stem Cells. 2008 Jul;26(7):1787-95
18499892
Int Endod J. 2008 Dec;41(12):1026-46
19133093
Stem Cells. 2008 Mar;26(3):638-45
18079433
PLoS One. 2006 Dec 20;1:e79
17183711
Eur J Dent. 2009 Jan;3(1):42-9
19262730
Arch Oral Biol. 1995 Oct;40(10):883-93
8526798
Dev Biol. 2001 Oct 1;238(1):120-32
11783998
J Endod. 2002 Jan;28(1):44-5
11806649
Pediatr Dent. 2008 May-Jun;30(3):211-9
18615986
Eur J Neurosci. 2004 May;19(9):2388-98
15128393
Tissue Eng. 2006 Aug;12(8):2069-75
16968149
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4391-6
11917100
Cell. 2001 Jun 29;105(7):829-41
11439179
J Endod. 2003 Mar;29(3):176-9
12669875
Gene Ther. 2002 Jun;9(12):814-8
12040463
Science. 2007 Dec 21;318(5858):1917-20
18029452
Med Mol Morphol. 2008 Dec;41(4):183-92
19107607
Biochem Biophys Res Commun. 2008 Jun 20;371(1):90-3
18407827
J Periodontal Res. 2008 Dec;43(6):595-603
18705651
J Endod. 2005 Oct;31(10):711-8
16186748
J Endod. 2007 Apr;33(4):377-90
17368324
Adv Dent Res. 2001 Aug;15:108-12
12640754