Direct catalytic asymmetric aldol reaction of beta-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex.
A homodinuclear Ni(2)-Schiff base 1 complex (0.1-1 mol%) promoted the direct catalytic asymmetric aldol reaction of beta-keto esters with formaldehyde, giving hydroxymethylated adducts in 94-66% ee.
Mouri
Shinsuke
S
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Chen
Zhihua
Z
Matsunaga
Shigeki
S
Shibasaki
Masakatsu
M
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D005557:Formaldehyde / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D004952:Esters; D009942:Organometallic Compounds; D012545:Schiff Bases; D005557:Formaldehyde; D009532:Nickel