Direct Copper-Free Domino Conjugate Addition-Cycloallylation using Organozinc Reagents.
The Direct Approach: Enones possessing appendant allylic carbonates react directly with diorganozinc reagents in the presence of zinc diiodide [ZnI(2)] to provide 5- and 6-membered ring products of tandem or domino conjugate addition-cycloallylation in good to excellent yield. In a related copper-free transformation, allylic carbonates are found to engage in direct allylic substitution with diorganozinc reagents.
Komanduri
Venukrishnan
V
University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station - A5300, Austin, TX 78712-1167, USA.
Pedraza
Fernando
F
Krische
Michael J
MJ
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