Characteristic peptides of protein secondary structural motifs.
Characteristic peptides of the protein segments having common secondary folds are obtained for the I-sites library using maximal position specific probability scores. The secondary structures of these peptides are predicted deploying two best-known computational methods. These are validated with significant accuracy against the corresponding motifs. The characteristic peptides also match with those computed using a Bayesian modeling approach with Markov Chain Monte Carlo Simulation. Percentage representation of the characteristic peptides in the protein structural and functional families shows some interesting results with potential applications in protein structural genomics.
Joshi
Rajani R
RR
Department of Mathematics, Indian Institute of Technology Bombay, India. rrj@iitb.ac.in
Sekharan
Sheeba
S
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D003198:Computer Simulation; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D017433:Protein Structure, Secondary
D010455:Peptides