title: Cardiovascular response during trigeminal ganglion compression for trigeminal neuralgia according to the use of local anesthetics.
abstract: OBJECTIVE
  There are controversies about the use of local anesthetics during balloon compression for trigeminal neuralgia (TN) as a protective factor for cardiovascular events. The objective of this study was to investigate cardiovascular parameters (blood pressure and heart rate [HR]) of patients that underwent trigeminal balloon compression with local anesthetics compared to a control group (placebo).
  
  
  METHODS
  This is a randomized controlled study; 55 patients were randomized into two groups: study (deep sedation and trigeminal block with 0.8-mL lidocaine 2%) and control group (deep sedation and trigeminal injection of 0.8-mL saline). Blood pressure and HR were measured in five distinct moments: preoperative, during puncture for local anesthesia/placebo, during puncture with the catheter, during balloon compression, and final evaluation. Statistical analysis was performed with Pearson's chi (2) and McNemar tests and the analysis of variance for repetitive measures.
  
  
  RESULTS
  The means of systolic and diastolic blood pressures (SBP and DBP, respectively) were higher in the control group when compared to the study group at the evaluation during puncture with the catheter (p < 0.001) and balloon compression (p < 0.001 and p = 0.018 for DBP and SBP, respectively). There was an increase in the HR in the control group during the procedure (p = 0.017).
  
  
  CONCLUSIONS
  The use of local anesthetics during the trigeminal balloon compression for TN can have a preventive role for the risk of cardiovascular events.
authors.affiliation: Neurology Department, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Adriana Tanaka
authors.initials: AT
authors.lastname: Tibano
authors.forename: Silvia Regina D T
authors.initials: SR
authors.lastname: de Siqueira
authors.forename: José Cláudio Marinho
authors.initials: JC
authors.lastname: da Nóbrega
authors.forename: Manoel Jacobsen
authors.initials: MJ
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D002404:Catheterization / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D016896:Treatment Outcome; D012668:Trigeminal Ganglion / Q000473:pathology / Q000601:surgery*; D014277:Trigeminal Neuralgia / Q000473:pathology / Q000601:surgery*
chemical_list: D000779:Anesthetics, Local