title: Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents.
abstract: OBJECTIVE
  To compare different oral ovulation induction agents in treating infertile women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Decision-analytic model comparing three treatment strategies using probability estimates derived from literature review and sensitivity analyses performed on the baseline assumptions.
  
  
  METHODS
  Outpatient reproductive medicine and gynecology practices.
  
  
  METHODS
  Infertile women with PCOS.
  
  
  METHODS
  Metformin, clomiphene citrate, or metformin with clomiphene citrate.
  
  
  METHODS
  Live birth.
  
  
  RESULTS
  Within the baseline assumptions, combination therapy with metformin and clomiphene citrate was the preferred therapy for achieving live birth in women with PCOS. Sensitivity analysis revealed the model to be robust over a wide range of probabilities.
  
  
  CONCLUSIONS
  Combination therapy with metformin and clomiphene citrate should be considered as first-line treatment for infertile women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri 63108, USA. jungheime@wudosis.wustl.edu
authors.forename: Emily S
authors.initials: ES
authors.lastname: Jungheim
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Odibo
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000465:Algorithms; D002996:Clomiphene / Q000008:administration & dosage* / Q000009:adverse effects; D003661:Decision Support Techniques; D004338:Drug Combinations; D005260:Female; D005298:Fertility / Q000187:drug effects; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D050498:Live Birth / Q000453:epidemiology; D008687:Metformin / Q000008:administration & dosage* / Q000009:adverse effects; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy
chemical_list: D004338:Drug Combinations; D005300:Fertility Agents, Female; D002996:Clomiphene; D008687:Metformin
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