Friedel-Crafts alkylation of arenes with epoxides promoted by fluorinated alcohols or water.
The stereoselective intra- and intermolecular Friedel-Crafts alkylation of electron-rich arenes with epoxides can take place in refluxing 1,1,1,3,3,3-hexafluoroisopropanol owing to its weak acidity and high ionizing power.
Li
Guo-Xing
GX
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Qu
Jin
J