Lipids in Alzheimer's disease: A century-old story.
Three neuropathological features attracted the attention of Alzheimer in his examination of the brain of Auguste Deter: abnormal fibrillary structures, cortical depositions now termed "plaques," and glial proliferation, whereby he noted remarkable lipid granule accumulation in the glia. These features were also recorded by Perusini and Kraepelin, but by 1930 the lipoid deposits were no longer regarded by neuropathologists with great interest.
Foley
Paul
P
Prince of Wales Medical Research Institute, Randwick (Sydney), NSW 2031, Australia. p.foley@powmri.edu.au
D000544:Alzheimer Disease / Q000209:etiology* / Q000266:history / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000502:physiology*
D008055:Lipids