Long-term clinical observation of the immunogenicity of inactivated hepatitis A vaccine in children.
110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoculated children remained positive for serum anti-HAV antibody, with a geometric mean concentration (GMC) of 61.59mIU/mL. GMC values following a secondary immunization in children with antibody levels <20mIU/mL were significantly elevated (567.9mIU/mL), compared with the primary injection alone. Havrix appears to induce persistent immunity and potent immune memory.
Bian
Guo-Lin
GL
Ningbo Municipal Center for Disease Control and Prevention, 237 Yongfeng Road, Ningbo, Zhejiang 315010, China.
Ma
Rui
R
Dong
Hong-Jun
HJ
Ni
Hong-Xia
HX
Hu
Feng-Jiao
FJ
Chen
Yao-Rong
YR
Chen
Jia-Qun
JQ
Zhou
Shao-Ying
SY
Lin
Yong-Xin
YX
Xu
Guo-Zhang
GZ
D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006506:Hepatitis A / Q000276:immunology* / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000032:analysis / Q000276:immunology; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007223:Infant; D008297:Male; D015233:Models, Statistical; D014611:Vaccination / Q000706:statistics & numerical data; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated
D000914:Antibodies, Viral; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated