title: Variation of Aujeszky's disease viruses in wild swine in USA.
abstract: In the United States of America, Aujeszky's disease (pseudorabies) has been eradicated from all domestic swine. Some re-emergence of infection occurred as vaccine use diminished. Sporadic outbreaks have also occurred because of the reservoir of infection in feral swine that have spread across the southern two-thirds of the country and Hawaii. In order to be able to understand the origins of re-emerging virus, sequence analysis of variable genes in pseudorabies virus (PRV) has been used to differentiate strains. Most PRV from feral swine can be distinguished from virus circulating in domestic pigs during the national epizootic. However, several feral swine isolates of PRV from south central states are closely related or identical in sequence to strains from domestic pigs. Extensive study by PCR for the presence of virus in the oral cavity of feral pigs disclosed that the viral DNA is distributed widely in tonsils salivary glands, taste buds and even mucosa in the vicinity of tusks. Clearly the virus in feral swine has multiple mechanisms of transmission to insure persistent infection and the threat of re-emergence in domestic swine continues.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 S Lincoln Ave., Urbana, IL 61802, USA. ned@illinois.edu
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Hahn
authors.forename: Bahaa
authors.initials: B
authors.lastname: Fadl-Alla
authors.forename: Carol A
authors.initials: CA
authors.lastname: Lichtensteiger
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D004196:Disease Outbreaks / Q000662:veterinary*; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011557:Pseudorabies / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D034421:Sus scrofa; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D014481:United States
chemical_list: D004279:DNA, Viral