title: Eosinophilia and eosinophilic infiltration into splenic B-cell high-grade lymphoma in a dog.
abstract: A 13-year-old mixed-breed dog showing ascites, anorexia and anemia was found to have leukocytosis with marked eosinophilia, splenomegaly and hepatomegaly. The dog died 4 days after initial presentation and was diagnosed with splenic high-grade B-cell lymphoma at necropsy. Remarkable infiltrations of eosinophils were observed in spleen and liver tissues. The eosinophilia and infiltration of eosinophils into the lesions could have been associated with B-cell lymphoma because causes other than lymphoma were excluded. This is the first report of eosinophilia and eosinophilic infiltrations into neoplastic lesions in a dog with high-grade B-cell lymphoma.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tomiyasu
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Jun
authors.initials: J
authors.lastname: Ugai
authors.forename: Yuko
authors.initials: Y
authors.lastname: Goto-Koshino
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ide
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayam
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000740:Anemia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000662:veterinary; D001201:Ascites / Q000209:etiology / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004802:Eosinophilia / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D016393:Lymphoma, B-Cell / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D010052:Ovariectomy / Q000662:veterinary; D011859:Radiography