A possible association between maternal otitis media and ear defect in their offspring.
BACKGROUND
The possible association between otitis media in pregnancy (OMP) and structural birth defects, that is, congenital abnormalities (CAs), in their offspring has not been studied.


METHODS
The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, was evaluated.


RESULTS
There were 58 (0.25%) and 55 (0.14%) of 22 843 cases and 38 151 controls with mothers who had OMP, respectively. There was association of OMP and a higher risk of ear CA.


CONCLUSIONS
A possible explanation for the association of OMP with higher risk of ear CA may be some morphological deviation of the inner ear.
Acs
Nándor
N
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary.
Bánhidy
Ferenc
F
Puhó
Erzsébet H
EH
Czeizel
Andrew E
AE
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D015897:Comorbidity; D016001:Confidence Intervals; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000453:epidemiology*; D004423:Ear / Q000002:abnormalities; D004427:Ear Diseases / Q000151:congenital / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016017:Odds Ratio; D010033:Otitis Media / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence; D012016:Reference Values; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
D000900:Anti-Bacterial Agents