Recovery of function following unilateral damage to visuoparietal cortex.
Damage to the visuoparietal cortex located in the banks of the middle suprasylvian gyrus of the cat has been shown to produce a deficit in the detection and localization of moving visual cues presented in the contralesional visual hemifield. There is evidence from reversible cooling deactivation studies that the integrity of this orienting function is not completely dependent on the VP cortex and that under the right circumstances, other brain regions may come online and completely take over the processing that subserves this behavior. We examined the recovery of orienting behavior after unilateral damage to the VP cortex. We found that consistent with previous data, VP damage produced an impairment in the capacity to detect and orient to moving visual stimuli in the contralesional visual field. Over a span of days, spontaneous recovery fully occurred. The ability to detect and localize static visual stimuli was tested as a fiducial measure of parietal cortex function, and this function did not recover. We conclude that the detection and localization of moving visual stimuli is not a function that requires VP cortex and argue for the existence of a parallel and redundant subcortical-cortical brain network that serves as the substrate for recovery of function.
Rushmore
R J
RJ
Laboratory for Cerebral Dynamics, Plasticity and Rehabilitation, Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, W702, Boston, MA 02118, USA. rushmore@bu.edu
Payne
Bertram
B
Valero-Cabre
Antoni
A
D000818:Animals; D001522:Behavior, Animal; D001931:Brain Mapping; D002247:Carbon Isotopes / Q000008:administration & dosage; D002415:Cats; D003847:Deoxyglucose / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D009039:Motion Perception / Q000502:physiology; D009949:Orientation / Q000502:physiology; D010296:Parietal Lobe / Q000293:injuries* / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D020127:Recovery of Function / Q000502:physiology*; D014795:Visual Pathways / Q000503:physiopathology
D002247:Carbon Isotopes; D003847:Deoxyglucose
Cereb Cortex. 1996 Nov-Dec;6(6):814-22
8922338
Exp Brain Res. 2003 Jun;150(3):395-8
12698319
Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7617-20
9207141
J Comp Neurol. 1988 Jul 22;273(4):527-42
3209736
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):290-4
8552624
J Comp Neurol. 2008 May 1;508(1):45-61
18300259
Exp Brain Res. 1983;49(1):84-92
6305699
Vis Neurosci. 2002 Jul-Aug;19(4):409-19
12511074
Exp Brain Res. 2006 Jul;172(4):485-97
16501961
Prog Brain Res. 1996;112:117-30
8979824
Behav Brain Res. 2004 Aug 31;153(2):557-65
15265654
Exp Brain Res. 2002 Feb;142(4):463-74
11845242
Vis Neurosci. 1996 Nov-Dec;13(6):1143-56
8961543
J Comp Neurol. 1990 Jun 8;296(2):222-52
2358533
Exp Brain Res. 2005 May;163(1):1-12
15688174
Vis Neurosci. 2003 Nov-Dec;20(6):687-701
15088720
Vis Neurosci. 1989 Oct;3(4):365-75
2487113
Vis Neurosci. 2001 May-Jun;18(3):487-99
11497424
Neuroscience. 2001;106(4):765-81
11682162
J Comp Neurol. 2004 Jun 21;474(2):190-208
15164422
Exp Neurol. 1965 Jan;11:115-46
14272555
J Neurophysiol. 1975 Nov;38(6):1403-20
1221079
J Neurosci. 1987 Apr;7(4):943-58
3572478
Science. 1966 Sep 23;153(3743):1544-7
5917786
Brain. 2006 Jul;129(Pt 7):1803-21
16731540
Cereb Cortex. 2004 Jan;14(1):81-90
14654459
J Comp Neurol. 2005 Aug 8;488(4):414-26
15973682
Brain Res. 1976 Jan 23;101(3):427-43
1244984
J Neurophysiol. 2007 Jul;98(1):545-9
17475717
Brain Res. 1979 Jul 27;171(1):11-28
223730