title: Obstetric outcomes of influenza A H1N1 (2009) infection in pregnancy--experience of a Singapore tertiary hospital.
abstract: BACKGROUND
  Influenza A H1N1 (2009) pandemic has affected countries worldwide including Singapore. Data on obstetric outcomes of women with H1N1 (2009) in pregnancy are lacking.
  
  
  METHODS
  This was an observational study analysing the obstetric outcomes of pregnant women with influenza A H1N1 (2009) infection who had delivered at a viable gestation (24 weeks or more) in our centre.
  
  
  RESULTS
  Between 23 June 2009 and 30 September 2009, 235 pregnant women were diagnosed with influenza A H1N1 (2009) at our centre, with 42 having delivered and comprising the study cohort. Median age was 27.5 years (range, 16 to 42). Multiparous women comprised 59.5% (25/42) whilst 40.5% (17/42) were primiparous. In terms of ethnicity, 61.9% were Malays, 26.2% Chinese, 4.8% Indians and 7.1% Others. All women received oseltamivir. All had shown recovery from the acute influenza infection. There were no respiratory complications. Twenty-nine women (69.0%) delivered at term. Twenty-fi ve women (59.5%) had spontaneous labour whilst 15 (35.7%) had labour induction. Two women (4.8%) did not labour. Thirty-six women (85.7%) had vaginal delivery, of whom 3 were instrumental deliveries. Apgar scores of greater than 8 at 1 min and 5 min were documented in babies of 95.2% (40/42) women, respectively. Thirty-two women (76.2%) delivered babies with birthweights greater than 2500 g. Compared with historical data from 2008, the H1N1 cohort had comparable mean birthweight and average gestational age at delivery of 38 weeks.
  
  
  CONCLUSIONS
  Our study suggested that obstetric outcomes were not adversely affected by influenza A H1N1 (2009) infection.
authors.affiliation: Department of Maternal-Fetal Medicine, KK Women's & Children's Hospital, Singapore.
authors.forename: May Li
authors.initials: ML
authors.lastname: Lim
authors.forename: Wai Yee
authors.initials: WY
authors.lastname: Lim
authors.forename: Nancy W S
authors.initials: NW
authors.lastname: Tee
authors.forename: Siok Hong
authors.initials: SH
authors.lastname: Lim
authors.forename: Jing Jye
authors.initials: JJ
authors.lastname: Chee
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology*; D009775:Obstetrics and Gynecology Department, Hospital; D053139:Oseltamivir / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011248:Pregnancy Complications; D012846:Singapore; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir