title: Diffusion tensor imaging of the cingulum bundle in children after traumatic brain injury.
abstract: Structural damage to the prefrontal-cingulate network has been implicated in cognitive and neurobehavioral deficits associated with traumatic brain injury (TBI). Forty-six children who had sustained moderate-to-severe TBI and 43 children with extracranial injury were imaged using diffusion tensor imaging (DTI). Decreased fractional anisotropy (FA) and increased apparent diffusion coefficient (ADC) values were found in the cingulum bundles bilaterally in the TBI group. Cingulum ADC was related to frontal lesion volume, injury severity, and injury mechanism. Finally, cingulum DTI parameters were related to cognitive control measures. DTI detects TBI-related injury to the cingulum, which may facilitate advances in assessment and treatment.
authors.affiliation: Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas-Houston Medical School, Houston, Texas 77030, USA. ewilde@bcm.edu
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Wilde
authors.forename: Marco A
authors.initials: MA
authors.lastname: Ramos
authors.forename: Ragini
authors.initials: R
authors.lastname: Yallampalli
authors.forename: Erin D
authors.initials: ED
authors.lastname: Bigler
authors.forename: Stephen R
authors.initials: SR
authors.lastname: McCauley
authors.forename: Zili
authors.initials: Z
authors.lastname: Chu
authors.forename: Trevor C
authors.initials: TC
authors.lastname: Wu
authors.forename: Gerri
authors.initials: G
authors.lastname: Hanten
authors.forename: Randall S
authors.initials: RS
authors.lastname: Scheibel
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Li
authors.forename: Ana C
authors.initials: AC
authors.lastname: Vásquez
authors.forename: Jill V
authors.initials: JV
authors.lastname: Hunter
authors.forename: Harvey S
authors.initials: HS
authors.lastname: Levin
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D001930:Brain Injuries / Q000150:complications / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D003072:Cognition Disorders / Q000209:etiology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009483:Neuropsychological Tests; D021641:Recognition, Psychology / Q000502:physiology; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D013223:Statistics as Topic / Q000379:methods
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