The immune enhancement of sodium lauryl sulfoacetate in chickens.
The purpose of this study is to investigate feasibility of sodium lauryl sulfoacetate (SLS) as an immunoadjuvant in chickens. After treating with 62.5, 125, 250, or 500 mug/mL SLS in vitro, lymphocyte proliferation assay of chicken peripheral blood mononuclear cells showed that the OD(570) values of all experimental groups, as well as Con A-stimulated group, were significantly higher than that of the untreated control group. After injection with 1.0, 2.0, or 4.0 mg/kg of SLS for 3 consecutive days, chickens were vaccinated with an attenuated vaccine against Newcastle disease virus (NDV), and the immunoadjuvant effects of SLS were evaluated on the basis of immune organ index, antibody response, and CD(4) (+)/CD(8) (+) T-cell ratio. The results confirmed that SLS could enhance NDV-specific antibody response and increase CD(4) (+)/CD(8) (+) T-cell ratio in vivo. Furthermore, SLS could improve NDV-specific antibody response in thiamphenicol-treated chickens. These data indicate that SLS not only can improve humoral immune response but also reverse the immunosuppressive effect of thiamphenicol in chickens.
Cheng
Darong
D
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Zhu
Shanyuan
S
Sun
Huaichang
H
J Ethnopharmacol. 2006 Mar 8;104(1-2):245-9
16213118
Am J Chin Med. 2001;29(2):303-12
11527072
J Ethnopharmacol. 2006 May 24;105(3):436-40
16384679
J Fluoresc. 2007 Jan;17(1):15-21
17160725
Zentralbl Veterinarmed B. 1997 Aug;44(6):365-70
9283287
Talanta. 2005 Nov 15;68(1):108-15
18970292
Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(16):1335-7
17061554
Eur J Cardiothorac Surg. 2002 Mar;21(3):497-501
11888770
J Ethnopharmacol. 2007 May 30;112(1):90-5
17368775
Biol Pharm Bull. 2005 Oct;28(10):1864-8
16204936
Chem Pharm Bull (Tokyo). 2006 Jul;54(7):936-40
16819207
Bull Exp Biol Med. 2005 Jan;139(1):101-4
16142290
Am J Chin Med. 2003;31(3):355-62
12943167
Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):929-31
17655149
Poult Sci. 2003 Aug;82(8):1266-73
12943297
Zhongguo Zhong Yao Za Zhi. 1990 Apr;15(4):221-2, 255
2119598
J Nutr Sci Vitaminol (Tokyo). 2003 Oct;49(5):327-33
14703307
World J Gastroenterol. 2005 Jan 21;11(3):389-92
15637750
Yao Xue Xue Bao. 2009 Jun;44(6):609-14
19806891
J Ethnopharmacol. 2008 Jun 19;118(1):79-85
18479853
Int Immunopharmacol. 2002 Sep;2(10):1411-8
12400871
Planta Med. 1995 Jun;61(3):237-41
7617766
Poult Sci. 2009 Oct;88(10):2118-24
19762865