A decade of epigenetic research in Toxoplasma gondii.
In the past 10 years, the field of parasitology has witnessed an explosion of studies investigating gene regulation. In this review, we will describe recent advances largely stemming from the study of Toxoplasma gondii, a significant opportunistic pathogen and useful model for other apicomplexan protozoa. Surprising findings have emerged, including the discovery of a wealth of epigenetic machinery in these primitive eukaryotes, unusual histone variants, and a battery of plant-like transcription factors. We will elaborate on how these unusual features impact parasite physiology and potential therapeutics as we summarize some of the key discoveries from the last decade. We will close by proposing a few questions to address in the next 10 years.
Dixon
Stacy E
SE
Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, 46202, United States.
Stilger
Krista L
KL
Elias
Eliana V
EV
Naguleswaran
Arunasalam
A
Sullivan
William J
WJ
D000818:Animals; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D014122:Toxoplasma / Q000235:genetics* / Q000502:physiology; D014123:Toxoplasmosis / Q000469:parasitology*
D006657:Histones; D015800:Protozoan Proteins
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