title: Biosynthesis of polyketides by trans-AT polyketide synthases.
abstract: This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
authors.affiliation: Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Bonn, Germany. joern.piel@uni-bonn.de
authors.forename: Jörn
authors.initials: J
authors.lastname: Piel
mesh_terms: D001688:Biological Products / Q000096:biosynthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D007783:Lactones; D018942:Macrolides; D048630:Polyketide Synthases; C036969:myxovirescin A