Biology and biotechnology of Trichoderma.
Fungi of the genus Trichoderma are soilborne, green-spored ascomycetes that can be found all over the world. They have been studied with respect to various characteristics and applications and are known as successful colonizers of their habitats, efficiently fighting their competitors. Once established, they launch their potent degradative machinery for decomposition of the often heterogeneous substrate at hand. Therefore, distribution and phylogeny, defense mechanisms, beneficial as well as deleterious interaction with hosts, enzyme production and secretion, sexual development, and response to environmental conditions such as nutrients and light have been studied in great detail with many species of this genus, thus rendering Trichoderma one of the best studied fungi with the genome of three species currently available. Efficient biocontrol strains of the genus are being developed as promising biological fungicides, and their weaponry for this function also includes secondary metabolites with potential applications as novel antibiotics. The cellulases produced by Trichoderma reesei, the biotechnological workhorse of the genus, are important industrial products, especially with respect to production of second generation biofuels from cellulosic waste. Genetic engineering not only led to significant improvements in industrial processes but also to intriguing insights into the biology of these fungi and is now complemented by the availability of a sexual cycle in T. reesei/Hypocrea jecorina, which significantly facilitates both industrial and basic research. This review aims to give a broad overview on the qualities and versatility of the best studied Trichoderma species and to highlight intriguing findings as well as promising applications.
Schuster
André
A
Research Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, Vienna University of Technology, Getreidemarkt 9/166-5, 1060, Vienna, Austria. andre.schuster@tuwien.ac.at
Schmoll
Monika
M
D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D007218:Industrial Microbiology; D014242:Trichoderma / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*
D005656:Fungal Proteins
Experientia. 1983 May 15;39(5):528-30
6406260
Fungal Genet Biol. 2005 Sep;42(9):749-60
15964222
J Bacteriol. 1979 Sep;139(3):761-9
39061
Appl Environ Microbiol. 2004 May;70(5):3073-81
15128569
Curr Genet. 2005 Aug;48(2):126-33
15959723
Mycobiology. 2006 Sep;34(3):111-3
24039481
Appl Environ Microbiol. 1999 Mar;65(3):1061-70
10049864
Commun Agric Appl Biol Sci. 2006;71(3 Pt B):953-61
17390844
Acta Microbiol Immunol Hung. 2003;50(2-3):105-17
12894482
Curr Genet. 1993 Oct;24(4):349-56
8252645
Appl Microbiol Biotechnol. 2010 Feb;85(5):1259-77
19915832
J Environ Sci Health B. 2008 Mar-Apr;43(3):237-40
18368544
Clin Infect Dis. 2008 May 15;46(10):e116-8
18419477
J Biotechnol. 1994 Nov 15;37(3):193-200
7765573
Appl Environ Microbiol. 2004 Jan;70(1):542-9
14711686
Mycol Res. 2005 Jun;109(Pt 6):658-60
16080389
Plant Physiol. 2006 Nov;142(3):1169-79
16950863
Fungal Genet Biol. 2010 Nov;47(11):909-16
20466064
BMC Genomics. 2009 Nov 30;10:567
19948043
J Biol Chem. 2003 Aug 22;278(34):31988-97
12788920
Mycologia. 2002 Jan-Feb;94(1):146-70
21156486
Appl Environ Microbiol. 2007 Nov;73(21):7048-58
17827332
Biotechnol Bioeng Symp. 1976;(6):9-20
826291
Eukaryot Cell. 2007 Dec;6(12):2332-42
17933910
Nature. 2008 Aug 14;454(7206):841-5
18704079
FEMS Microbiol Lett. 2009 Nov;300(1):58-67
19735461
Acta Biol Hung. 2005;56(1-2):137-50
15813222
Fungal Genet Biol. 2005 Oct;42(10):813-28
16154784
FEMS Microbiol Lett. 2009 Oct;299(2):135-42
19702879
Biotechnol Biofuels. 2008 Dec 23;1(1):18
19105830
Mycoses. 2008 Mar;51(2):95-8
18254744
Chem Biodivers. 2008 May;5(5):671-80
18493954
Eukaryot Cell. 2003 Jun;2(3):446-55
12796289
Fungal Genet Biol. 1998 Feb;23(1):34-44
9501476
Mol Plant Microbe Interact. 2009 Mar;22(3):291-301
19245323
FEMS Microbiol Lett. 2010 Feb;303(1):26-32
20002748
Curr Genet. 2005 Jun;47(6):381-8
15856359
J Microbiol Methods. 2010 May;81(2):187-93
20302890
Int Microbiol. 2003 Sep;6(3):191-9
12898399
Regul Toxicol Pharmacol. 2004 Apr;39(2):214-28
15041150
Curr Genet. 2005 Sep;48(3):204-11
16091959
J Agric Food Chem. 2005 Oct 19;53(21):8190-6
16218663
Appl Environ Microbiol. 2005 Mar;71(3):1591-7
15746364
Microbiology (Reading). 2007 Jun;153(Pt 6):1734-1742
17526831
Chem Biodivers. 2007 Jun;4(6):1052-67
17589876
Acta Biochim Biophys Sin (Shanghai). 2008 Feb;40(2):158-65
18235978
Appl Microbiol Biotechnol. 2009 Jun;83(4):649-57
19205687
J Ind Microbiol Biotechnol. 2008 May;35(5):377-391
18338189
Biotechnology (N Y). 1993 May;11(5):591-5
7763606
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16151-6
19805272
Mycopathologia. 1997;139(3):151-5
16283454
J Biotechnol. 1991 Jan;17(1):35-49
1367015
Acta Microbiol Immunol Hung. 2005;52(2):169-84
16003937
Gene Regul Syst Bio. 2007 Nov 08;1:227-34
19936091
Microbiology (Reading). 2007 Oct;153(Pt 10):3417-3437
17906141
Clin Microbiol Infect. 2004 Mar;10 Suppl 1:48-66
14748802
Clin Infect Dis. 2002 Dec 1;35(11):1360-7
12439799
BMC Plant Biol. 2007 Jul 30;7:41
17663762
Rapid Commun Mass Spectrom. 2008 Jun;22(12):1889-98
18470867
Microbiology (Reading). 2008 Apr;154(Pt 4):1229-1241
18375815
Lett Appl Microbiol. 2009 Jun;48(6):705-11
19413806
Biotechnol Biofuels. 2009 Sep 01;2:19
19723296
Inflamm Res. 1998;47 Suppl 1:S5-6
9561390
Curr Genet. 2007 May;51(5):331-42
17415567
Trends Biotechnol. 2005 Sep;23(9):468-74
15967521
Experientia. 1984 Nov 15;40(11):1189-97
6500005
J Med Microbiol. 2006 Jan;55(Pt 1):31-35
16388027
J Antimicrob Chemother. 2006 Nov;58(5):1058-61
16987867
Chem Biodivers. 2007 Jun;4(6):1068-82
17589877
Curr Genet. 2009 Feb;55(1):81-91
19116716
Nat Prod Rep. 2007 Oct;24(5):1128-41
17898900
Phytopathology. 2007 Apr;97(4):532-7
18943294
Biotechnol Lett. 2009 Apr;31(4):531-6
19116694
Adv Appl Microbiol. 2004;56:313-30
15566984
Mol Microbiol. 2007 Nov;66(4):890-900
17924946
Curr Biol. 2007 Feb 20;17(4):R115-9
17307040
Phytopathology. 2006 Feb;96(2):190-4
18943924
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15965-70
14673101
Acta Biochim Pol. 2008;55(3):447-56
18797519
J Biotechnol. 2009 Jan 15;139(2):146-51
19027803
J Zhejiang Univ Sci B. 2008 Oct;9(10):753-63
18837102
Commun Agric Appl Biol Sci. 2007;72(1):219-23
18018891
BMC Genomics. 2007 Dec 04;8:449
18053205
Eukaryot Cell. 2002 Aug;1(4):594-605
12456007
J Agric Food Chem. 2008 Aug 27;56(16):6914-22
18642836
FEMS Microbiol Lett. 2006 Apr;257(1):145-51
16553845
Microbiology (Reading). 2007 Jul;153(Pt 7):2137-2147
17600058
J Pept Sci. 2003 Nov-Dec;9(11-12):666-78
14658788
Fungal Genet Biol. 2007 Dec;44(12):1355-67
17881256
Biotechnol Adv. 2009 Nov-Dec;27(6):833-848
19577626
Eur J Biochem. 2002 Sep;269(17):4202-11
12199698
BMC Genomics. 2008 Jul 11;9:327
18620557
Fungal Genet Biol. 1996 Jun;20(2):105-14
8810515
Stud Mycol. 2009;63:1-91
19826500
Curr Opin Biotechnol. 1995 Oct;6(5):534-7
7579664
Curr Genet. 2008 Dec;54(6):283-99
18836726
Curr Genet. 1990 Jul;18(1):71-6
2245476
Appl Environ Microbiol. 2010 Apr;76(7):2345-52
20154111
Fungal Genet Biol. 2007 Nov;44(11):1123-33
17509915
Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):549-56
12448750
Acta Microbiol Immunol Hung. 2004;51(3):283-95
15571068
Lett Appl Microbiol. 2006 Aug;43(2):143-8
16869896
Int J Biol Sci. 2009 Sep 04;5(6):578-95
19774110
Appl Microbiol Biotechnol. 2003 Jan;60(5):515-22
12536250
Fungal Genet Biol. 2003 Apr;38(3):310-9
12684020
Appl Environ Microbiol. 2006 Mar;72(3):2126-33
16517662
Gene. 1987;61(2):155-64
3127274
Acta Microbiol Immunol Hung. 2003;50(2-3):125-45
12894484
Fungal Genet Biol. 2001 Aug;33(3):155-71
11495573
Plant Dis. 2000 Apr;84(4):377-393
30841158
Microbiology (Reading). 2008 Nov;154(Pt 11):3447-3459
18957598
Eukaryot Cell. 2005 Dec;4(12):1998-2007
16339718
Genome Res. 2001 Jul;11(7):1246-55
11435407
J Appl Microbiol. 2001 Nov;91(5):806-13
11722657
Appl Environ Microbiol. 2007 Nov;73(22):7415-26
17827333
Phytopathology. 2006 Feb;96(2):181-5
18943922
Curr Genet. 1994 Jun;25(6):567-70
8082210
Plant Physiol. 2008 Jun;147(2):779-89
18400936
Int J Biochem. 1993 Nov;25(11):1637-51
8288033
Nat Biotechnol. 2008 May;26(5):553-60
18454138
PLoS One. 2010 Feb 12;5(2):e9191
20169200
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13909-14
19667182
Annu Rev Phytopathol. 2010;48:21-43
20192757
Appl Environ Microbiol. 2005 Oct;71(10):6241-6
16204544
Mycopathologia. 2000 Jan;149(1):21-5
11227850
Curr Genet. 2006 Nov;50(5):307-21
17008992
Adv Biochem Eng Biotechnol. 2007;108:95-120
17594064
Mol Plant Microbe Interact. 2006 Aug;19(8):838-53
16903350
Phytopathology. 2006 Feb;96(2):195-206
18943925
Eukaryot Cell. 2009 Mar;8(3):410-20
19136572
BMC Microbiol. 2009 Oct 13;9:217
19825185
Mycopathologia. 1997;137(2):115-24
16284721
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7755-60
8755548
Curr Genet. 2004 Feb;45(1):54-60
14586554
BMC Genomics. 2008 Sep 20;9:430
18803869
Toxicon. 1999 Jan;37(1):77-83
9920482
Int Microbiol. 2001 Mar;4(1):1-4
11770814
Int Microbiol. 2004 Dec;7(4):249-60
15666245
Acta Microbiol Immunol Hung. 2005;52(3-4):341-50
16400874