title: The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions.
abstract: Here we aimed to first investigate the clinical value of combined detection of MG7-Ag and COX-2 (cyclo-oxygenase 2) in prediction of advances in gastric precancerous lesions. Immunohistochemical analysis was used to examine the expression of MG7-Ag and COX-2 in 396 cases of patients with gastric precancerous lesions, including 66 cases of atrophic gastritis, 106 cases of intestinal metaplasia, 174 cases of low-moderate-grade dysplasia and 50 cases of high-grade dysplasia. The relation of MG7-Ag and COX-2 staining with various clinicopathological features was analysed by follow-up study. The positive rates of MG7-Ag and COX-2 were increased gradually from atrophic gastritis (21.2%, 28.8%), intestinal metaplasia (36.8%, 44.3%), low-moderate-grade dysplasia (51.4%, 58.6%) to high-grade dysplasia (72%, 80%). Double positive staining of MG7-Ag and COX-2 in gastric precancerous lesions had an increased risk of precancerous progression over 22 times, compared with negative ones. However, the expression of MG7-Ag and COX-2 was not significantly correlated with age and gender of patients. MG7-Ag and COX-2 might play an important role in the process of carcinogenesis and progression of gastric cancer. Combined detection of MG7-Ag and COX-2 was of value of predicting early gastric cancer from precancerous lesions.
authors.affiliation: State Key Laboratory of Tumor Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian, 710032, Shaanxi Province, Peoples Republic of China.
authors.forename: Liu
authors.initials: L
authors.lastname: Hong
authors.forename: Shujun
authors.initials: S
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Shi
authors.forename: Kaichun
authors.initials: K
authors.lastname: Wu
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000201:enzymology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; C508753:MG7 antigen, human; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human