Neural correlates of strategic processes underlying episodic memory in women with major depression: A 15O-PET study.
To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words (eight healthy females, IQ=122, and eight depressed females, IQ=107). Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation.
Ottowitz
William E
WE
Department of Statistics, Columbia University, New York, NY 10027, USA. weo2101@columbia.edu
Deckersbach
Thilo
T
Savage
Cary R
CR
Lindquist
Martin A
MA
Dougherty
Darin D
DD
D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003463:Cues; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods; D021641:Recognition, Psychology / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
D010104:Oxygen Radioisotopes