title: Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles (Sonazoid) for hepatic malignancies: an initial experience.
abstract: OBJECTIVE
  Conventional contrast harmonic sonography has the technical problem of a short enhancement time during targeting of hepatic malignancies for radiofrequency (RF) ablation. This study investigated the effectiveness of contrast harmonic sonographic guidance using perfluorocarbon microbubbles (Sonazoid) during RF ablation of hepatic malignancies.
  
  
  METHODS
  Nodules were detected on contrast-enhanced computed tomography, but could not be resolved clearly by B-mode sonography. Sixty-six patients (51 men, 15 women; mean age, 65.8 years) with 108 hepatic malignancies were enrolled. Fifty-one patients with hepatocellular carcinoma and 15 patients with liver metastases were treated by RF ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles for a target lesion identified as a defect image after the administration of contrast medium.
  
  
  RESULTS
  The maximal diameters of all tumours ranged from 0.7 to 3.5 cm (mean +/- SD, 1.7 cm +/- 0.9) on sonography. Complete tumour necrosis was achieved by a single session of RF ablation in 62 (94%) of the 66 patients, while two sessions were required for the remaining four (6%) patients. The average number of treatment sessions was 1.1 +/- 0.3. In the post-vascular phase, 105 (97%) of a total of 108 malignant hepatic tumours were depicted as a defect with a margin. Clinical courses have been satisfactory without any signs of local tumour progression during 1-12 months of follow-up (mean, 4.3 months).
  
  
  CONCLUSIONS
  Using perfluorocarbon microbubbles, contrast harmonic sonographic-guided RF ablation is an efficient approach for guiding further ablation of hepatic malignancies that are not clearly demarcated by B-mode sonography.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kinki University School of Medicine, Ohno-Higashi Osaka-Sayama, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Minami
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kudo
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kitai
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Inoue
authors.forename: Satoru
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Hobyung
authors.initials: H
authors.lastname: Chung
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Ueshima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D007501:Iron; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D045423:Microbubbles; D008875:Middle Aged; D010087:Oxides; D010743:Phospholipids; D013459:Sulfur Hexafluoride; D014463:Ultrasonography
chemical_list: D005290:Ferric Compounds; D010087:Oxides; D010743:Phospholipids; C069727:Sonazoid; C420843:contrast agent BR1; D007501:Iron; D013459:Sulfur Hexafluoride