[Modulators of the regulatory protein activity acting at microdoses].
New, previously not studied bioregulators active in the ultra low doses corresponding of 10(-8) - 10(-17) mg/ml have been isolated from vitreoretinal tissue of eye. It has been shown that these bioregulators comprise some regulatory peptides-modulators represented by proteins with molecular weights 15-70 KDa one of which is bovine serum albumin. Correlation between the nanosize of bioregulators and their ability to show activity in ultra low doses is established.
Iamskova
V P
VP
Krasnov
M S
MS
Skripnikova
V S
VS
Moliavka
A A
AA
Il'ina
A P
AP
Margasiuk
D V
DV
Borisenko
A V
AV
Berezin
B B
BB
Iamskov
I A
IA
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004591:Electrophoresis, Polyacrylamide Gel; D005123:Eye / Q000737:chemistry* / Q000187:drug effects*; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry; D009924:Organ Culture Techniques; D010316:Particle Size; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D010999:Pleurodeles; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D055213:Retinal Pigment Epithelium / Q000737:chemistry; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*
D010455:Peptides; D011506:Proteins; D014020:Tissue Extracts