title: Traumatic brain injury: preferred methods and targets for resuscitation.
abstract: OBJECTIVE
  Severe traumatic brain injury (TBI) is the most common cause of death and disability in pediatric trauma. This review looks at the strategies to treat TBI in a temporal fashion. We examine the targets for resuscitation from field triage to definitive care in the pediatric ICU.
  
  
  RESULTS
  Guidelines for the management of pediatric TBI exist. The themes of contemporary clinical research have been compliance with these guidelines and refinement of treatment recommendations developing a more sophisticated understanding of the pathophysiology of the injured brain. In the field, the aim has been to achieve routine compliance with the resuscitation goals. In the hospital, efforts have been directed at improving our ability to monitor the injured brain, developing techniques that limit brain swelling, and customizing brain perfusion.
  
  
  CONCLUSIONS
  As our understanding of pediatric TBI evolves, the ambition is that age-specific and perhaps individual brain injury strategies based upon feedback from continuous monitors will be defined. In addition, vogue methods such as hypothermia, hypertonic saline, and aggressive surgical decompression may prove to impact brain swelling and outcomes.
authors.affiliation: Pediatric Trauma Service, Department of Surgery, Division of Pediatric Surgery, University of Utah, Salt Lake City, Utah, USA. eric.scaife@hsc.utah.edu
authors.forename: Eric R
authors.initials: ER
authors.lastname: Scaife
authors.forename: Kimberly D
authors.initials: KD
authors.lastname: Statler
mesh_terms: D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D002648:Child; D003422:Critical Care / Q000379:methods*; D019299:Decompression, Surgical; D006801:Humans; D007036:Hypothermia, Induced; D008991:Monitoring, Physiologic / Q000379:methods; D017410:Practice Guidelines as Topic; D012151:Resuscitation / Q000379:methods*; D012462:Saline Solution, Hypertonic; D014218:Triage
chemical_list: D012462:Saline Solution, Hypertonic