Parathyroid hormone-related peptide-producing non-familial pheochromocytoma in a child.
We experienced a case of parathyroid hormone-related peptide (PTHrP)-producing pheochromocytoma, which was found in a 12-year-old boy with hypercalcemia. The leading symptom was abdominal pain, and severe hypertension and tachycardia were noticed at the initial visit. His medical and familial histories were unremarkable. Laboratory examinations showed hypercalcemia (3.3 mmol/L of serum-calcium). Computed tomography showed a heterogeneous mass measuring 5.0 cm in the right adrenal gland, which had abnormal uptake with 123-I metaiodobenzylguanidine scintigraphy. Serum/urine catecholamines were highly elevated, and serum PTHrP also increased (1.4 pmol/L). The patient underwent laparoscopic right adrenalectomy. The tumor was histologically diagnosed as typical pheochromocytoma and the expression of PTHrP was confirmed with immunohistochemistry. The serum PTHrP level was normalized after surgery. He was free of disease postoperatively for 12 months. There has been no described pediatric patient with PTHrP-producing pheochromocytoma. We showed evidence that the present tumor is a complex neoplasm involving various neuroendocrine activities with the dual-lineage differentiation.
Takeda
Keisuke
K
Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Hara
Noboru
N
Kawaguchi
Makoto
M
Nishiyama
Tsutomu
T
Takahashi
Kota
K
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002648:Child; D006801:Humans; D008297:Male; D044162:Parathyroid Hormone-Related Protein / Q000096:biosynthesis*; D010673:Pheochromocytoma / Q000175:diagnosis / Q000378:metabolism*
D044162:Parathyroid Hormone-Related Protein