title: Novel and simple carbon-11-labeled ammonium salts as PET agents for myocardial perfusion imaging.
abstract: BACKGROUND
  Positron emission tomography (PET) has clear advantages over single photon emission computed tomography (SPECT) in the field of myocardial perfusion scintigraphy (MPS); however, there are just a small number of efficient PET tracers available today for MPS. We sought to develop and perform a preliminary biological evaluation of novel carbon-11-labeled ammonium salts as potential MPS PET agents.
  
  
  RESULTS
  Three potential tracers were labeled and evaluated via biodistribution in mice and PET imaging in both rats and rabbits, and the results obtained were also compared to agents that are routinely used in the clinical practice.
  
  
  CONCLUSIONS
  The results designated carbon-11-labeled ammonium salts as having great potential as MPS PET agents. Specifically, carbon-11-labeled trimethyl-phenyl-ammonium iodide ([(11)C]2) and homologues of higher lipophilicity/charge warrant further studies in larger animals and humans such as measurements of myocardial uptake at rest and stress under both normal and pathological coronary flow conditions.
authors.affiliation: Cyclotron/Radiochemistry Unit/Nuclear Medicine Department, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel.
authors.forename: Ohad
authors.initials: O
authors.lastname: Ilovich
authors.forename: Hana
authors.initials: H
authors.lastname: Billauer
authors.forename: Sharon
authors.initials: S
authors.lastname: Dotan
authors.forename: Nanette M T
authors.initials: NM
authors.lastname: Freedman
authors.forename: Moshe
authors.initials: M
authors.lastname: Bocher
authors.forename: Eyal
authors.initials: E
authors.lastname: Mishani
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011786:Quality Control; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics*; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002250:Carbon Radioisotopes; D000644:Quaternary Ammonium Compounds