Influence of genotype on dopamine transporter availability in human striatum and sleep architecture.
Genetic variants may modulate dopamine transporter (DAT) availability in the brain. A polymorphism within the intron 8 of the DAT1 gene was evaluated in 27 healthy men. No correlation between Int8 VNTR and either the inter-individual variability of the sleep architecture, or the DAT availability, as measured by single photon emission computed tomography (SPECT) and [(⁹⁹m)Tc]TRODAT-1 was observed.
Guindalini
Camila
C
Department of Psychobiology - Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, Brazil.
Martins
Raquel Cristina
RC
Andersen
Monica L
ML
Tufik
Sergio
S
D000328:Adult; D000704:Analysis of Variance; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005133:Eye Movements / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D015609:Organotechnetium Compounds; D012890:Sleep / Q000235:genetics*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes; D055815:Young Adult
D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; C493214:SLC6A3 protein, human; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1