Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1).
Costa
Emmanoel Vilaça
EV
Departamento de Quimica, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/n, Rosa Elze, 49100-000, Sao Cristovao, SE, Brazil. emmanoelvilaca@yahoo.com.br
Pinheiro
Maria Lúcia B
ML
Barison
Andersson
A
Campos
Francinete R
FR
Salvador
Marcos J
MJ
Maia
Beatriz Helena L N S
BH
Cabral
Elaine C
EC
Eberlin
Marcos N
MN
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry; D001938:Brazil; D002175:Candida / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D031043:Guatteria / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
C550959:9-methoxy-O-methylmoschatoline; C550960:9-methoxyisomoschatoline; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D001060:Aporphines; C550961:isocerasonine; C062700:xylopine