Quantification of the familial contribution to juvenile idiopathic arthritis.
OBJECTIVE
We previously demonstrated that there is familial aggregation of juvenile idiopathic arthritis (JIA). Using a large JIA cohort, we sought to identify additional clusters of JIA cases and to calculate robust estimates of the relative risk (RR) of JIA in the siblings and cousins of JIA probands. We also estimated the population attributable risk (PAR) of familial factors in JIA.


METHODS
A probabilistic record-linking analysis was performed by matching the records of 862 patients with JIA with the records of approximately 7 million individuals in the Utah Population Database (UPDB), a computerized genealogic database. For each patient, 5 control subjects matched for birth year and sex were selected from the UPDB. Specialized software was used to test for familial aggregation of disease, to estimate the magnitude of familial risks, and to identify families at high risk of disease.


RESULTS
We identified 22 founders who had significantly more descendants with JIA than expected (5-13 descendants; P values ranged from <0.0001 to <0.008). The PAR of familial factors for JIA was approximately 13%. The RR of JIA in the siblings of patients was significantly increased (11.6, 95% confidence interval [95% CI] 4.9-27.5, P < 2.59 x 10(-8)). The RR of JIA in first cousins was also increased (5.82, 95% CI 2.5-13.8, P < 6.07 x 10(-5)).


CONCLUSIONS
We have identified the largest sets of JIA pedigrees described to date. Approximately 13% of cases of JIA can be attributed to familial factors. Siblings and first cousins of probands with JIA have an increased risk of JIA. The observed decline in the magnitude of risk between siblings and cousins suggests that JIA is influenced by shared genetic factors.
Prahalad
Sampath
S
Division of Pediatric Rheumatology, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA. sprahal@emory.edu
Zeft
Andrew S
AS
Pimentel
Richard
R
Clifford
Bronte
B
McNally
Bernadette
B
Mineau
Geraldine P
GP
Jorde
Lynn B
LB
Bohnsack
John F
JF
D001171:Arthritis, Juvenile / Q000235:genetics*; D016022:Case-Control Studies; D016208:Databases, Factual; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D008297:Male; D010375:Pedigree; D012306:Risk; D012307:Risk Factors; D014589:Utah