title: Enantioselective organocatalytic addition of azlactones to maleimides: a highly stereocontrolled entry to 2,2-disubstituted-2H-oxazol-5-ones.
abstract: The first highly diastereo- and enantioselective organocatalytic synthesis of 2,2-disubstituted-2H-oxazol-5-ones is described. The addition of oxazolones to maleimides is promoted by bifunctional thiourea catalysts, which afford the corresponding 2,2-disubstituted-2H-oxazol-5-ones with total regio- and stereocontrol.
authors.affiliation: Department of Organic Chemistry, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain.
authors.forename: Andrea-Nekane R
authors.initials: AN
authors.lastname: Alba
authors.forename: Guillem
authors.initials: G
authors.lastname: Valero
authors.forename: Teresa
authors.initials: T
authors.lastname: Calbet
authors.forename: Mercé
authors.initials: M
authors.lastname: Font-Bardía
authors.forename: Albert
authors.initials: A
authors.lastname: Moyano
authors.forename: Ramon
authors.initials: R
authors.lastname: Rios