Paramagnetic liposome nanoparticles for cellular and tumour imaging.
In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal imaging neutral nanoparticles for in vivo imaging applications. We discuss the development of such systems and show how paramagnetic liposomes and imaging nanoparticles could be developed as platforms for future multi-functional, multi-modal imaging theranostic nanodevices tailor-made for the combined imaging of early stage disease pathology and functional drug delivery.
Kamaly
Nazila
N
Department of Chemistry, Imperial College Genetic Therapies Centre, Imperial College London, UK. nazila.kamaly@imperial.ac.uk
Miller
Andrew D
AD
D003287:Contrast Media / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D011859:Radiography
D003287:Contrast Media; D008081:Liposomes