Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens.
Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It was observed that two of the synthesized compounds exhibited relatively good antibacterial and antifungal activities.
Arumugam
Natarajan
N
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India.
Raghunathan
Raghavachary
R
Shanmugaiah
Vellaisamy
V
Mathivanan
Narayanasamy
N
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000382:microbiology; D013141:Spiro Compounds / Q000138:chemical synthesis; D013329:Structure-Activity Relationship; D044024:Tetralones / Q000138:chemical synthesis* / Q000494:pharmacology; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002839:Chromans; D007555:Isoxazoles; D013141:Spiro Compounds; D044024:Tetralones; D047090:beta-Lactams