title: [A meta-analysis of the safety of simultaneous versus staged resection for synchronous liver metastasis from colorectal cancer].
abstract: OBJECTIVE
  To evaluate the safety of simultaneous and staged resection for synchronous liver metastasis from colorectal cancer.
  
  
  METHODS
  PubMed/Medline, ISI Web of Knowledge, Springer link, ebscohost, Elsevier Wiley Interscience, Google Scholar were searched for case-control studies concerning simultaneous versus staged resection of synchronous liver metastasis from colorectal cancer between January 1989 and March 2009. A meta-analysis was performed to analyze the morbidity and perioperative mortality.
  
  
  RESULTS
  Seven case-control studies, with a total of 1390 patients of liver metastasis from colorectal cancer undergone curative hepatic resection, were reviewed. There were 495 simultaneous and 895 staged resections. Perioperative mortality was 1.1% in the staged resection group and 2.4% in the the simultaneous group, the difference was statistically significant[Peto OR 3.39, 95% CI 1.29-8.93, P=0.01]. No significant difference was found in morbidity between two groups[OR(random)0.88, 95% CI 0.51-1.51, P=0.64].
  
  
  CONCLUSIONS
  Selective staged resection is safe for synchronous liver metastasis from colorectal cancer.
authors.affiliation: Department of Oncological Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, China.
authors.forename: Guo-qing
authors.initials: GQ
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Ke-feng
authors.initials: KF
authors.lastname: Ding
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D009367:Neoplasm Staging