Relics of selection in the mycobacterial genome.
A new study reports the whole-genome sequences of 21 Mycobacterium tuberculosis complex strains, selected to represent geographically diverse isolates. Comparative genomic analyses identify surprising conservation of epitopes recognized by human T cells.
Sassetti
Christopher M
CM
Rubin
Eric J
EJ
D000942:Antigens, Bacterial; D001500:BCG Vaccine / Q000276:immunology; D017124:Conserved Sequence; D018984:Epitopes, T-Lymphocyte; D016680:Genome, Bacterial; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology*; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000517:prevention & control
D000942:Antigens, Bacterial; D001500:BCG Vaccine; D018984:Epitopes, T-Lymphocyte