title: Neural control of muscle.
abstract: Cholinergic innervation regulates the physiological and biochemical properties of skeletal muscle. The mechanisms that appear to be involved in this regulation include soluble, neurally-derived polypeptides, transmitter-evoked muscle activity and the neurotransmitter, acetylcholine, itself. Despite extensive research, the interacting neural mechanisms that control such macromolecules as acetylcholinesterase, the acetylcholine receptor and glucose 6-phosphate dehydrogenase remain unclear. It may be that more simplified in vitro model systems coupled with recent dramatic advances in the molecular biology of neurally-regulated proteins will begin to allow researchers to unravel the mechanisms controlling the expression and maintenance of these macromolecules.
authors.affiliation: Departments of Neurology and Anatomy, University of Maryland, School of Medicine, Baltimore, Maryland 21201, U.S.A.
authors.forename: S R
authors.initials: SR
authors.lastname: Max
authors.forename: G J
authors.initials: GJ
authors.lastname: Markelonis