Microcapsules with self-microemulsifying core: optimization of shell-forming phase.
Microcapsules with self-microemulsifying core were originated by the vibrating nozzle method. Alginate-pectin (A/P) ratio of the shell forming phase was optimized with regard to core phase retention and drug release kinetics from dried microcapsules. Well shaped microcapsules with high encapsulation efficiency were produced when an A/P composition of 25:75 was used. Microcapsules with higher pectin content exhibited faster drug release, which was additionally enhanced by the addition of sodium chloride to the shell phase.
Zvonar
A
A
Faculty of Pharmacy, University of Ljubljana, Slovenia.
Gasperlin
M
M
D002214:Capsules / Q000737:chemistry*; D003890:Desiccation; D004232:Diuretics / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D004655:Emulsions; D005079:Excipients; D005665:Furosemide / Q000008:administration & dosage / Q000737:chemistry; D007700:Kinetics; D010368:Pectins; D012965:Sodium Chloride; D012995:Solubility
D002214:Capsules; D004232:Diuretics; D004655:Emulsions; D005079:Excipients; D012965:Sodium Chloride; D005665:Furosemide; D010368:Pectins