Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294.
A new bioactive compound of the N-acylhydrazone class, LASSBio-294, was shown to produce a cardioinotropic effect and vasodilation. In this study, we report the structure-based drug metabolism prediction, biosynthesis and identification of the major mammalian metabolite of LASSBio-294.
Carneiro
Emmanuel O
EO
Laboratório de Bioconversão, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Andrade
Carolina H
CH
Braga
Rodolpho C
RC
Tôrres
Andréa C B
AC
Alves
Rosângela O
RO
Lião
Luciano M
LM
Fraga
Carlos A M
CA
Barreiro
Eliezer J
EJ
de Oliveira
Valéria
V
D000818:Animals; D052982:Beauveria / Q000378:metabolism; D002316:Cardiotonic Agents / Q000378:metabolism*; D004285:Dogs; D006835:Hydrazones / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013876:Thiophenes / Q000378:metabolism*; D014664:Vasodilation / Q000187:drug effects*
D002316:Cardiotonic Agents; D006835:Hydrazones; C439284:LASSBio 294; D013876:Thiophenes