Effect of dietary tea polyphenols on growth performance and cell-mediated immune response of post-weaning piglets under oxidative stress.
To gain insights into the effects of tea polyphenols (TP) on growth performance and cell-mediated immune response of piglets under oxidative stress, an oxidative stress model was established by intraperitoneally injecting weaned piglets with diquat. After intake of either basal diet or TP-supplemented diet for 7 d, half of the piglets in each group were challenged with diquat. Results showed that dietary TP alleviated growth depression to some extent. A T lymphocyte transformation test (LTT) demonstrated that TP promoted the proliferation and activation of T lymphocytes. The ratio of CD4+/CD8+ was elevated, indicating a recovering tendency from immune damages caused by oxidative stress. The increment of pro-inflammatory IL-1 caused by oxidative stress was attenuated, and the concentration of serum IFN-gamma was decreased by TP-supplementation. However, the serum concentrations of anti-inflammatory cytokine, such as IL-4, were greatly enhanced by TP, which suggested an immune shift from Th1 to Th2. These findings supported the immunomodulatory potential of TP for piglets subjected to oxidative stress.
Deng
Qilan
Q
Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Ya'an, Sichuan, P.R. China.
Xu
Jing
J
Yu
Bing
B
He
Jun
J
Zhang
Keying
K
Ding
Xuemei
X
Chen
Daiwen
D
D000821:Animal Feed / Q000032:analysis*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D004032:Diet / Q000662:veterinary*; D004178:Diquat; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D013552:Swine / Q000254:growth & development* / Q000276:immunology; D014886:Weaning
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D004178:Diquat