title: Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl)cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides.
abstract: A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl)cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl)cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compounds including N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarboxamide (2c) and N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarbothiamide (3c) demonstrated significant cytotoxicity against three cancer cell lines (A549, MCF7-MDR and HT1080) while most of compounds exhibited moderate inhibitory effects on the growth of Staphyllococcus aureus and some other fungi.
authors.affiliation: Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam. nhnam@etal.uri.edu
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Nam
authors.forename: Phan Thi Phuong
authors.initials: PT
authors.lastname: Dung
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Tran Thi
authors.initials: TT
authors.lastname: Hien
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D052160:Benzothiazoles; C558227:N-(6-ethoxybenzo(d)thiazol-2-yl)cyclohexanecarbothiamide; C558226:N-(6-ethoxybenzo(d)thiazol-2-yl)cyclohexanecarboxamide