title: Bioactivity of sesquiterpenes: compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage.
abstract: Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.
authors.affiliation: Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, Junín 956, C1113AAD Buenos Aires, Argentina. mrepetto@ffyb.uba.ar
authors.forename: M G
authors.initials: MG
authors.lastname: Repetto
authors.forename: A
authors.initials: A
authors.lastname: Boveris
mesh_terms: D000431:Ethanol / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D018384:Oxidative Stress; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000627:therapeutic use; D013272:Stomach Diseases / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D018836:Inflammation Mediators; D012717:Sesquiterpenes; D000431:Ethanol