Genetic variation in TGF-beta 1 gene promoter and risk of gestational trophoblastic disease.
OBJECTIVE
To examine the relationship of transforming growth factor beta 1 (TGF-beta 1) gene polymorphisms at promoter positions -509 (C/T) and -800 (G/A) with the risk of gestational trophoblastic disease (GTD) as compared to normal controls


METHODS
Polymerase chain reaction-restriction fragment length polymorphism was performed on peripheral blood of 102 patients with GTD and 124 normal, healthy, pregnant women as the control group.


RESULTS
In this study, TGF-beta 1 gene polymorphisms at positions -509 (C/T) and -800 (G/A) failed to correlate with GTD.


CONCLUSIONS
Our findings suggest that promoter gene polymorphisms of TGF-beta 1 do not play major roles in GTD and may not be risk factors for this disease.
Dehaghani
Alamtaj Samsami
AS
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
Zamanpour
Tarlan
T
Naeimi
Sirous
S
Sameni
Safoura
S
Robati
Minoo
M
Ghaderi
Abbas
A
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D031901:Gestational Trophoblastic Disease / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D053773:Transforming Growth Factor beta1