title: Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases.
abstract: After the introduction of highly active antiretroviral therapies (HAART), an increased incidence of insulin resistance, diabetes mellitus (DM), and cardiovascular diseases has been described. The impact of such conditions on mortality in the post-HAART era has been also assessed in various modes in the literature. In this paper, we report on the death risks for DM, myocardial infarction, and chronic ischemic heart diseases that were investigated among 9662 Italian AIDS cases diagnosed between 1999 and 2005. Death certificates reporting DM, myocardial infarction, and chronic ischemic heart diseases were reviewed to identify the underlying cause of death, and to compare the observed numbers of deaths with the expected ones from the sex- and age-matched, general population of Italy. Person-years at risk of death were computed from date of AIDS diagnosis up to date of death or to December 31, 2006. Standardized mortality ratios (SMR) and their 95% confidence intervals (CI) were computed. DM and cardiovascular diseases were the cause of death for 43 out of 3101 deceased AIDS cases (i.e., 1.4% of all deaths). In comparison with the general population, the risks of death were 6.4-fold higher for DM (95% CI:3.5-10.8), 2.3-fold higher for myocardial infarction (95% CI:1.4-3.7) and 3.0 for chronic ischemic heart diseases (95% CI: 1.5-5.2).
authors.affiliation: Unit of Epidemiology and Biostatistics, Centro di Riferimento Onocologico, IRCCS, Aviano, Italy. serrainod@cro.it.
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.forename: Silvia
authors.initials: S
authors.lastname: Bruzzone
authors.forename: Antonella
authors.initials: A
authors.lastname: Zucchetto
authors.forename: Barbara
authors.initials: B
authors.lastname: Suligoi
authors.forename: Angela
authors.initials: A
authors.lastname: De Paoli
authors.forename: Simona
authors.initials: S
authors.lastname: Pennazza
authors.forename: Laura
authors.initials: L
authors.lastname: Camoni
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Paoli
authors.initials: P
authors.lastname: De Paoli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rezza