Interleukin-1 beta regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model.
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-beta on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1 beta activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.
Fontana
Vanina Andrea
VA
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Sanchez
Melisa
M
Cebral
Elisa
E
Calvo
Juan Carlos
JC
D002460:Cell Line; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000494:pharmacology*; D020738:Leptin / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008954:Models, Biological; D011247:Pregnancy; D014327:Trophoblasts / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
D053583:Interleukin-1beta; D020738:Leptin; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9