AIM2 joins the gang of microbial sensors.
AIM2 was recently implicated in the assembly and activation of the inflammasome in response to eukaryotic and viral dsDNA. Sauer and colleagues (2010) demonstrate that AIM2 is also involved in the activation of the inflammasome in response to the intracellular bacterium Listeria monocytogenes.
Franchi
Luigi
L
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nuñez
Gabriel
G