title: Bone density consequences of initiation and compliance with therapy for osteoporosis.
abstract: OBJECTIVE
  There are many effective osteoporosis (OP) medications with a variety of dosing intervals and delivery options, but even when diagnosed, OP is often undertreated. We sought to determine the bone density consequences of the decision to initiate and comply with therapy for OP.
  
  
  METHODS
  We identified 243 women who received a dual x-ray absorptiometry (DXA) evaluation and fulfilled the World Health Organization criteria for OP. One year later, the patients were asked to return for a followup DXA. Administrative electronic health records were used to identify prescription drug use.
  
  
  RESULTS
  A total of 142 women (58%) initiated pharmacologic therapy for OP during the year after the initial DXA; 144 returned for a followup DXA after 1 year. For those women with ≥66% of days receiving therapy, the mean annual change in spine bone mineral density (BMD) was 4.5% compared with 2.0% for those with <66% of days receiving therapy and 0.8% for those not receiving OP therapy (P < 0.001). For those women with ≥66% of days receiving therapy, the mean change in hip BMD was 2.3% compared with 0.3% for those with <66% of days receiving therapy and -0.8% for those not receiving OP therapy (P < 0.001).
  
  
  CONCLUSIONS
  We found significant bone density consequences of the decision to initiate and comply with therapy in the first year after diagnosis of OP. Improvement in both initiation rates of treatment as well as compliance are needed in order to reduce the frequency of osteoporotic fractures.
authors.affiliation: Fallon Clinic and Meyers Primary Care Institute, Worcester, Massachusetts 01605, USA. robert.yood@fallonclinic.org
authors.forename: Robert A
authors.initials: RA
authors.lastname: Yood
authors.forename: Susan E
authors.initials: SE
authors.lastname: Andrade
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Mazor
authors.forename: Hassan
authors.initials: H
authors.lastname: Fouayzi
authors.forename: Wing
authors.initials: W
authors.lastname: Chan
authors.forename: Kristijan
authors.initials: K
authors.lastname: Kahler
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000523:psychology; D010349:Patient Compliance / Q000523:psychology
chemical_list: D050071:Bone Density Conservation Agents