title: [A case of stage IV gastric cancer with multiple liver metastases surviving for more than 4 years by treatment with chemotherapies without surgery].
abstract: A 75-year-old male who with type 3 gastric cardia cancer with multiple liver metastases was initially treated with S-1 in July of 2005. After 4 courses of the treatment, the liver metastases became undetectable on abdominal CT scan, with reduction in size of the primary tumor of the stomach. After 7 months of S-1 treatment, however, the progression of the primary lesion was endoscopically detected, and irinotecan was administered, demonstrating primary tumor regression. When re-growth of the primary tumor was observed, 3 courses of paclitaxel treatment showed little effect and was replaced by docetaxel treatment for 5 months, which had a grade 3 adverse effect. The next 10 courses of 5-FU combined with methotrexate were applied for one year until the primary tumor showed enlargement. Then 12 courses of CDDP with S-1 were administered until now, and the size of the primary carcinoma is under control. The patient is being followed on an outpatient basis without any surgical treatment, while the liver metastases have not relapsed on abdominal imaging.
authors.affiliation: Division of Biological Regulation and Oncology, Tohoku University.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Ando
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kanno
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyashita
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Fumie
authors.initials: F
authors.lastname: Ikezawa
authors.forename: Chikashi
authors.initials: C
authors.lastname: Shibata
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshioka
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005773:Gastroscopy; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D009367:Neoplasm Staging; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents