Aseptic meningitis in adult onset Still's disease.
Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy, and a neutrophilic leukocytosis. Though systemic complications of AOSD or its treatment are well described in the literature, CNS involvement in AOSD is exceedingly rare and can have protean manifestations. We present a patient with AOSD who developed chronic meningitis and sensorineural hearing loss on treatment, with a review of prior reported cases of aseptic meningitis, to highlight this rare complication of this uncommon illness.
Akkara Veetil
Bharath Manu
BM
Division of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. akkaraveetil.bharathmanu@mayo.edu
Yee
Alan H
AH
Warrington
Kenneth J
KJ
Aksamit
Allen J
AJ
Mason
Thomas G
TG
D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008582:Meningitis, Aseptic / Q000209:etiology*; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000188:drug therapy
D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate