title: Immunohistochemical expression of growth factors in the exocrine pancreas of patients with chronic liver diseases.
abstract: Acute viral hepatitis has been reported to cause acute pancreatitis. It was also reported that exocrine pancreatic function is damaged in chronic liver disease (CLD). Growth factors stored in the extracellular matrix and released in the course of pancreatic degradation are major mediators of inductive processes. The immunostaining technique was used to evidence the changes of the expression of the growth factors in different pancreatic cells. VEGF and FGF-beta are involved in the angiogenesis processes and in the evolution of the pancreatic interstitial tissue in case of chronic pancreatitis. Theses markers can also be used for the diagnosis of pancreatitis, but their value is variable. They stimulate the pancreatic star cells, the myofibroblasts and play an important role in the genesis of the extracellular matrix and in the repairing of the tissue after the aggression. TGF beta is important for its role in cellular differentiation and growth and in the development of the fibrosis in liver and other organs. The present paper studies the immunohistochemical expression of these growth factors in pancreatic cells.
authors.affiliation: Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania. garo2963@yahoo.com.
authors.forename: Garofiţa
authors.initials: G
authors.lastname: Mateescu
authors.forename: Maria
authors.initials: M
authors.lastname: Comănescu
authors.forename: Rodica
authors.initials: R
authors.lastname: Mehedinţi
authors.forename: Zizi
authors.initials: Z
authors.lastname: Niculescu
authors.forename: Adriana
authors.initials: A
authors.lastname: Bold
authors.forename: Laurenţia
authors.initials: L
authors.lastname: Panduru
authors.forename: Daniela
authors.initials: D
authors.lastname: Cernea
mesh_terms: D002908:Chronic Disease; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D008107:Liver Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male; D046790:Pancreas, Exocrine / Q000378:metabolism* / Q000473:pathology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins