title: Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.
abstract: Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. lara.chepenik@yale.edu
authors.forename: Lara G
authors.initials: LG
authors.lastname: Chepenik
authors.forename: Mariella
authors.initials: M
authors.lastname: Raffo
authors.forename: Michelle
authors.initials: M
authors.lastname: Hampson
authors.forename: Cheryl
authors.initials: C
authors.lastname: Lacadie
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Monique M
authors.initials: MM
authors.lastname: Jones
authors.forename: Brian
authors.initials: B
authors.lastname: Pittman
authors.forename: Pawel
authors.initials: P
authors.lastname: Skudlarski
authors.forename: Hilary P
authors.initials: HP
authors.lastname: Blumberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000098:blood supply / Q000503:physiopathology*; D001714:Bipolar Disorder / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply / Q000503:physiopathology*; D012146:Rest / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen