title: Predicting visual function from the measurements of retinal nerve fiber layer structure.
abstract: OBJECTIVE
  To develop and validate a method of predicting visual function from retinal nerve fiber layer (RNFL) structure in glaucoma.
  
  
  METHODS
  RNFL thickness (RNFLT) measurements from scanning laser polarimetry (SLP) and visual field (VF) sensitivity from standard automated perimetry were made available for 535 eyes from three centers. In a training dataset, structure-function relationships were characterized by using linear regression and a type of neural network: radial basis function customized under a Bayesian framework (BRBF). These two models were used in a test dataset to (1) predict sensitivity at individual VF locations from RNFLT measurements and (2) predict the spatial relationship between VF locations and positions at a peripapillary RNFLT measurement annulus. Predicted spatial relationships were compared with a published anatomic structure-function map.
  
  
  RESULTS
  Compared with linear regression, BRBF yielded a nearly twofold improvement (P < 0.001; paired t-test) in performance of predicting VF sensitivity in the test dataset (mean absolute prediction error of 2.9 dB [SD 3.7] versus 4.9 dB [SD 4.0]). The predicted spatial structure-function relationship showed better agreement (P < 0.001; paired t-test) with anatomic prior knowledge when the BRBF was compared with the linear regression (median absolute angular difference of 15° vs. 62°).
  
  
  CONCLUSIONS
  The BRBF generates clinically useful relationships that relate topographical maps of RNFL measurement to VF locations and allows the VF sensitivity to be predicted from structural measurements. This method may allow clinicians to evaluate structural and functional measures in the same domain. It could also be generalized to use other structural measures.
authors.affiliation: Department of Optometry and Visual Science, City University London, London, United Kingdom.
authors.forename: Haogang
authors.initials: H
authors.lastname: Zhu
authors.forename: David P
authors.initials: DP
authors.lastname: Crabb
authors.forename: Patricio G
authors.initials: PG
authors.lastname: Schlottmann
authors.forename: Hans G
authors.initials: HG
authors.lastname: Lemij
authors.forename: Nicolaas J
authors.initials: NJ
authors.lastname: Reus
authors.forename: Paul R
authors.initials: PR
authors.lastname: Healey
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Tuan
authors.initials: T
authors.lastname: Ho
authors.forename: David F
authors.initials: DF
authors.lastname: Garway-Heath
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005188:False Negative Reactions; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D057109:Scanning Laser Polarimetry; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D055815:Young Adult