The transport, biosynthesis and biochemical actions of taurine in a genetic epilepsy.
We have investigated the transport, biosynthesis and turnover of taurine in genetically seizure-susceptible (SS) and seizure-resistant (SR) rats. In SS rats, the rate of taurine uptake into the brain was half the rate in SR rats. As no difference was found in biosynthesis of taurine, these results imply a slower turnover of taurine in SS brain. The effect of taurine on the decarboxylation of glutamate in brain homogenates was determined. In homogenates of SR brains, taurine had no effect but in SS preparations taurine increased the rate of decarboxylation by 20%. Increased decarboxylation of glutamate may be one basis for the prolonged anticonvulsant action of taurine in the SS rat.
Bonhaus
D W
DW
University of Arizona, Department of Pharmacology, Health Sciences Center, Tucson, AZ 85724, U.S.A.
Huxtable
R J
RJ