title: [Melanomas more serious in the elderly].
abstract: Two patients, a 96-year-old woman and a 94-year-old man, were diagnosed with metastatic cutaneous melanoma. The first patient had undergone radical excision of the primary tumour 18 months before. The second patient presented with neurological symptoms caused by a metastatic melanoma; the primary tumour had recently been resected. Both patients died within three weeks of the diagnosis. Cutaneous melanomas have a high metastatic rate. Treatment options are limited for metastatic disease. The incidence of melanoma increases with age. Old age is an independent risk factor, which is also associated with a poor prognosis. Older patients more often present with more serious histological characteristics and more aggressive types of melanoma. The Breslow thickness is also higher in patients aged 65 or over. Nodular melanoma, lentigo maligna or acral lentiginous melanoma are observed more frequently in this group of patients. Moreover, elderly people more frequently present with liver or cerebral metastases. Early diagnosis improves the prognosis, also in the elderly.
authors.affiliation: Erasmus Medisch Centrum, Afd. Inwendige Geneeskunde, Rotterdam, The Netherlands. w.vandermeijden@erasmusmc.nl
authors.forename: Wilbert A G
authors.initials: WA
authors.lastname: van der Meijden
authors.forename: Rozemarijn L
authors.initials: RL
authors.lastname: van Bruchem-Visser
authors.forename: H Bing
authors.initials: HB
authors.lastname: Thio
authors.forename: Tischa J M
authors.initials: TJ
authors.lastname: van der Cammen
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D009362:Neoplasm Metastasis; D011379:Prognosis; D012307:Risk Factors; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology*