Concentrations of thyrotropin-releasing hormone and substance P are increased in several areas of the central nervous system of shambling mutant mice.
The concentrations of thyrotropin-releasing hormone (TRH) and substance P (SP) in the brain of shambling mouse, a mutant mouse which is neurologically defective showing trunk instability and hind limb incoordination, were measured by radioimmunoassay. The TRH concentrations were significantly higher in the pons, medulla oblongata and spinal cord. The SP concentrations were also significantly higher in the thalamus, pons, thoracic and lumbar spinal cord. The findings suggest that changes in TRH and SP concentration in the brain might be relevant to the motor dysfunction of shambling mouse.
Mitsuma
T
T
Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Aichi 480-11 Japan.
Adachi
K
K
Mukoyama
M
M
Ohsugi
K
K
Ando
K
K