title: Increasing effect of a high dose of PG-1 peptide on the infectivity of Chlamydophila abortus.
abstract: Cathelicidins are antimicrobial peptides, stored by mammalian leukocytes, showing an antimicrobial activity against bacteria, fungi, protozoa and enveloped viruses. In accordance with other authors, we reported in a previous study that the protegrin-1 (PG-1), at 80 microg mL(-1), inhibited the in vitro growth of Chlamydia trachomatis serovars D, H and L2; however, we observed an increased infectivity of some animal chlamydial species after their treatment with the same PG-1 concentration. In this study, the treatment of LLC-MK2 cells with PG-1 before chlamydial infection resulted in an increased infectivity of Chlamydophila abortus probably due to their easier entry into the host cells, whereas no increase in S26/3 infectivity was detected in LLC-MK2 cells treated with PG-1 postchlamydial infection.
authors.affiliation: Policlinico S. Orsola, University of Bologna, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Donati
authors.forename: Antonietta
authors.initials: A
authors.lastname: Di Francesco
authors.forename: Renato
authors.initials: R
authors.lastname: Gennaro
authors.forename: Monica
authors.initials: M
authors.lastname: Benincasa
authors.forename: Maria
authors.initials: M
authors.lastname: Di Paolo
authors.forename: Alisa
authors.initials: A
authors.lastname: Shurdhi
authors.forename: Fabio
authors.initials: F
authors.lastname: Ostanello
authors.forename: Raffaella
authors.initials: R
authors.lastname: Baldelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Cevenini
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D002460:Cell Line; D023501:Chlamydophila / Q000187:drug effects* / Q000472:pathogenicity*; D002479:Inclusion Bodies / Q000382:microbiology; D008253:Macaca mulatta
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C094880:protegrin-1