[Fibroblast growth factor 23--a phosphate regulating hormone].
Fibroblast growth factor 23 (FGF23) is a recently identified phosphatonin. Its main physiological functions are to maintain serum phosphate within its reference range and to counter regulate the effects of vitamin D. Diseases correlated to high serum values of FGF23 are hypophosphatemic rickets, fibrous dysplasia, and tumour-induced osteomalacia. In contrast, hyperphosphatemic tumoral calcinosis is associated with accelerated degradation of FGF23. Measuring FGF23 serves as a differential diagnostic tool in elucidating conditions of long-lasting hypophosphatemia.
Beck-Nielsen
Signe Sparre
SS
H.C. Andersen Børnehospital, Afdeling for Biokemi, Farmakologi og Genetik, Odense Universitetshospital, 5000 Odense C, Denmark. sbeck-nielsen@dadlnet.dk
Pedersen
Susanne Møller
SM
Kassem
Moustapha
M
Rasmussen
Lars Melholt
LM
D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000097:blood; D003937:Diagnosis, Differential; D053098:Familial Hypophosphatemic Rickets / Q000097:blood; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood / Q000502:physiology*; D005357:Fibrous Dysplasia of Bone / Q000097:blood; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D054559:Hyperphosphatemia / Q000097:blood / Q000175:diagnosis; D017674:Hypophosphatemia / Q000097:blood / Q000175:diagnosis; D009369:Neoplasms / Q000097:blood; D010710:Phosphates / Q000097:blood
D015415:Biomarkers; C000717427:FGF23 protein, human; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23