Potential effects of chrysin on MDA-MB-231 cells.
This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 microM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
Hong
Teh Ban
TB
Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia. banhong86@hotmail.com
Rahumatullah
Anizah
A
Yogarajah
Thaneswary
T
Ahmad
Maimunah
M
Yin
Khoo Boon
KB
D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D005419:Flavonoids; D047493:PPAR alpha; D012333:RNA, Messenger; C043561:chrysin