title: Skull base metastasis from follicular thyroid carcinoma -two case reports-.
abstract: A 58-year-old woman and a 71-year-old woman presented with extremely rare skull base metastases from follicular thyroid carcinoma (FTC). Surgical removal and external radiotherapy were performed followed by iodine-131 ((131)I) brachytherapy and thyroid hormone administration. The metastatic tumors in the skull base were well controlled. Treatment for skull base metastasis from FTC includes surgical debulking of the metastatic lesion, as well as complete resection of the thyroid gland, followed by internal irradiation with (131)I, external irradiation, and administration of thyroid hormone to prevent tumor growth by suppression of endogenous thyroid-stimulating hormone. Skull base metastases may be the initial clinical presentation of FTC, with silent primary sites. The possibility of skull base metastasis from FTC should be considered in patients with clinical symptoms of cranial nerve dysfunction and radiological findings of bone destruction.
authors.affiliation: Department of Neurosurgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan. akirakun@med.teikyo-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuno
authors.forename: Hideki
authors.initials: H
authors.lastname: Katakami
authors.forename: Ryo
authors.initials: R
authors.lastname: Okazaki
authors.forename: So
authors.initials: S
authors.lastname: Yamada
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakaguchi
authors.forename: Shoko M
authors.initials: SM
authors.lastname: Yamada
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hoya
authors.forename: Mineko
authors.initials: M
authors.lastname: Murakami
authors.forename: Kazuto
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ishida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Jyunpei
authors.initials: J
authors.lastname: Kuyama
authors.forename: Kennichi
authors.initials: K
authors.lastname: Kakudo
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001918:Brachytherapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008875:Middle Aged; D011859:Radiography; D035583:Rare Diseases; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D013963:Thyroid Hormones / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007457:Iodine Radioisotopes; D013963:Thyroid Hormones