title: Low efficacy of atrial fibrillation ablation in severe obstructive sleep apnoea patients.
abstract: OBJECTIVE
  Atrial fibrillation (AF) ablation efficacy varies according to patients' clinical characteristics. Although the association of obstructive sleep apnoea (OSA) and AF is well established, data on AF ablation efficacy in OSA are scarce. The aim of this study was to clarify the effect of OSA on the outcome of AF ablation.
  
  
  RESULTS
  A series of 174 consecutive patients without polysomnography submitted to circumferential pulmonary vein ablation were included in the study. All patients were assessed by Berlin Questionnaire (BQ) and underwent an echocardiogram and a clinical evaluation. Patients with a high BQ score, indicating high risk for OSA, participated in a sleep study. Diagnoses were classified according to the apnoea-hypoapnoea index (AHI) as mild (AHI < 10/h), non-severe (AHI < 30/h), or severe (AHI >or= 30/h) OSA. Follow-up consisted of outpatient visits and 24 or 48 h Holter monitoring at 1, 4, and 7 months, and every 6 months thereafter. Any episode of AF or left atrial (LA) flutter was considered recurrence. Fifty-one (29.3%) patients had high BQ scores. The sleep study showed that 17 (9.8%) and 25 (14.4%) of these patients had non-severe and severe OSA, respectively. One-year arrhythmia-free probability after a single ablation procedure was 48.5% in patients with low risk for OSA (low BQ score or AHI < 10/h), 30.4% in the non-severe OSA group (10 < AHI < 30/h) and 14.3% in the severe OSA group (AHI >or= 30). Anteroposterior LA diameter [hazard ratio (HR) = 1.046, 95% confidence interval (CI): 1.005-1.089; P = 0.029] and severe OSA (HR = 1.870, 95% CI: 1.106-3.161; P = 0.019) were the independent predictors of arrhythmia recurrence.
  
  
  CONCLUSIONS
  In patients with AF ablation, the presence of severe OSA is an independent predictor for AF ablation failure.
authors.affiliation: Arrhythmia Section, Cardiology Department, Thorax Institute, Hospital Clínic Universitari, Institut de Investigació Biomèdica August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Catalonia, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Matiello
authors.forename: Mercé
authors.initials: M
authors.lastname: Nadal
authors.forename: David
authors.initials: D
authors.lastname: Tamborero
authors.forename: Antonio
authors.initials: A
authors.lastname: Berruezo
authors.forename: Josep
authors.initials: J
authors.lastname: Montserrat
authors.forename: Cristina
authors.initials: C
authors.lastname: Embid
authors.forename: Jose
authors.initials: J
authors.lastname: Rios
authors.forename: Julián
authors.initials: J
authors.lastname: Villacastín
authors.forename: Josep
authors.initials: J
authors.lastname: Brugada
authors.forename: Lluís
authors.initials: L
authors.lastname: Mont
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000601:surgery*; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D045422:Continuous Positive Airway Pressure / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011237:Predictive Value of Tests; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy