Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer.
The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.
Sabitha
Gowravaram
G
Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. gowravaramsr@yahoo.com
Srinivas
Rangavajjula
R
Das
Sukant K
SK
Yadav
Jhillu S
JS