TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand.
OBJECTIVE
To investigate association of TIM1 sequence variations with HIV/AIDS progression.


BACKGROUND
: HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response.


METHODS
We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplotypes. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated.


RESULTS
Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4 cell count (P = 0.06) and lower proportion of AIDS-related symptoms (P = 0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P = 0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1.


CONCLUSIONS
TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females.
Wichukchinda
Nuanjun
N
National institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Nakajima
Toshiaki
T
Saipradit
Nongluk
N
Nakayama
Emi E
EE
Ohtani
Hitoshi
H
Rojanawiwat
Archawin
A
Pathipvanich
Panita
P
Ariyoshi
Koya
K
Sawanpanyalert
Pathom
P
Shioda
Tatsuo
T
Kimura
Akinori
A
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015497:HIV-1; D006239:Haplotypes; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D011991:Receptors, Virus / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis; D019562:Viral Load
C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus