title: Genetic variation in TGF-beta 1 gene promoter and risk of gestational trophoblastic disease.
abstract: OBJECTIVE
  To examine the relationship of transforming growth factor beta 1 (TGF-beta 1) gene polymorphisms at promoter positions -509 (C/T) and -800 (G/A) with the risk of gestational trophoblastic disease (GTD) as compared to normal controls
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism was performed on peripheral blood of 102 patients with GTD and 124 normal, healthy, pregnant women as the control group.
  
  
  RESULTS
  In this study, TGF-beta 1 gene polymorphisms at positions -509 (C/T) and -800 (G/A) failed to correlate with GTD.
  
  
  CONCLUSIONS
  Our findings suggest that promoter gene polymorphisms of TGF-beta 1 do not play major roles in GTD and may not be risk factors for this disease.
authors.affiliation: Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alamtaj Samsami
authors.initials: AS
authors.lastname: Dehaghani
authors.forename: Tarlan
authors.initials: T
authors.lastname: Zamanpour
authors.forename: Sirous
authors.initials: S
authors.lastname: Naeimi
authors.forename: Safoura
authors.initials: S
authors.lastname: Sameni
authors.forename: Minoo
authors.initials: M
authors.lastname: Robati
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D031901:Gestational Trophoblastic Disease / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1