Monoclonal anti-torpedo receptor antibodies used to study antibody heterogeneity in myasthenic sera.
Monoclonal antibodies against Torpedo acetylcholine receptor were used to define the binding regions of cross-reacting, anti-receptor antibodies from sera of myasthenic patients. Cross-reacting antibodies were directed mainly against the toxin-binding region of the receptor and a region remote from the acetylcholine-binding site. Few patients had antibodies against the acetylcholine-binding site region. The monoclonal antibodies provide probes for defining the heterogeneity of anti-receptor antibodies in myasthenic sera.
James
R W
RW
Dept. of Biochemistry, University of Geneva, Geneva, Switzerland.
Lefvert
A K
AK
Alliod
C
C
Fulpius
B W
BW