[Effect of melatonin on the blood oxygen-carrying function and prooxidant-antioxidant balance after lipopolysaccharide injection].
Effects of melatonin on the blood oxygen-carrying function and prooxidant - antioxidant balance in the organism were studied 12 h after lipopolysaccharide injection in rabbits. The treatment with melatonin (intraperitoneally in a dose of 4 mg/kg) before endotoxic lipopolysaccharide injection (intravenously 500 microg/kg) improved oxygen transport function of the blood, increased the hemoglobin-oxygen affinity, decreased nitrates/nitrites level, reduced the gain of free-radical processes, and increased the level of antioxidant protection factors in test animals. It is concluded that melatonin modulates the blood oxygen-carrying function and prooxidant - antioxidant balance through NO-dependent mechanisms, thus reducing the negative action of endotoxin on the organism.
Zinchuk
V V
VV
Shul'ga
E V
EV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D005609:Free Radicals / Q000097:blood; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000378:metabolism* / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen / Q000097:blood*; D011817:Rabbits; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D008070:Lipopolysaccharides; D008550:Melatonin; D010100:Oxygen