Change in the distribution of acetylcholinesterase molecular forms in the rat superior cervical ganglion after NaBr treatment in vivo.
Acetylcholinesterase (AChE) activity and the distribution of its molecular forms were investigated in the superior cervical ganglion of adult rats that had been given 27 mM bromide in drinking water for periods ranging from 2 days to 2 months. Chronic bromide treatment of adult rat caused an approx. 20% inhibition of the AChE activity in the superior cervical ganglion, while there was a significant elevation in the relative amount of the A(12)AChE molecular form (146%, P < 0.01). The results suggest that the bromide-induced formation of non-innervated postsynaptic membrane thickenings may promote the accumulation of A(12)AChE.
Rakonczay
Z
Z
Central Research Laboratory, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Kása
P
P
Wolff
J R
JR