Analysis of two polymorphisms of the manganese superoxide dismutase gene (Ile-58Thr and Ala-9Val) in patients with recurrent depressive disorder.
Reactive oxygen species (ROS) may contribute to the pathogenesis of depressive disorder (DD). Functional genetic polymorphisms of manganese superoxide dismutase (MnSOD) are candidates for DD susceptibility. The study examined the relationship between MnSOD gene polymorphisms (Ala-9Val, Ile-58Thr) and DD in the Polish population. The association study was conducted in a case-control design in DD patients (n=149) and healthy controls (CG; n=149) by genotyping. Assessment of Ala-9Val genotype distribution and disease odds ratio demonstrated a statistically significant difference between the compared groups only in the female subgroup. The obtained results suggest a role of the MnSOD polymorphism in the development and course of depression.
Gałecki
Piotr
P
Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159 st., 91-229 Lodz, Poland. galeckipiotr@wp.pl
Smigielski
Janusz
J
Florkowski
Antoni
A
Bobińska
Kinga
K
Pietras
Tadeusz
T
Szemraj
Janusz
J
D000409:Alanine; D000596:Amino Acids / Q000235:genetics*; D016022:Case-Control Studies; D003863:Depression / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007532:Isoleucine; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D013912:Threonine; D014633:Valine
D000596:Amino Acids; D007532:Isoleucine; D013912:Threonine; D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine