Electrosprayed core-shell microspheres for protein delivery.
This communication describes a single-step electrospraying technique that generates core-shell microspheres (CSMs) with encapsulated protein as the core and an amphiphilic biodegradable polymer as the shell. The protein release profiles of the electrosprayed CSMs showed steady release kinetics over 3 weeks without a significant initial burst.
Wu
Yiquan
Y
Materials Science Program, Department of Mechanical Engineering, University of Rochester, Rochester, New York 14627, USA. wuyiquan@me.rochester.edu
Liao
I-Chien
IC
Kennedy
Scott J
SJ
Du
Jinzhi
J
Wang
Jun
J
Leong
Kam W
KW
Clark
Robert L
RL
D007700:Kinetics; D008863:Microspheres; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
D011091:Polyesters; D011108:Polymers; D011506:Proteins; C016240:polycaprolactone