title: Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia.
abstract: Although a number of studies have found prospective memory (PM) impairment in patients with schizophrenia, very little is known about the PM performance in non-psychotic relatives of these patients. The current study aimed to explore the PM performance in non-psychotic first-degree relatives of these patients. Two groups of participants (26 non-psychotic first-degree relatives of schizophrenia patients and 26 healthy comparison participants) were administered three PM tasks (time-, event-, and activity-based) and a set of neurocognitive tests. Results showed that the relatives performed significantly worse than the comparisons on most indices of the PM tasks, with a similar pattern of impairment found in other neurocognitive measures. Together with findings from previous studies, results of the current study suggest that PM may be a potential endophenotype for schizophrenia.
authors.affiliation: Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
authors.forename: Jifang
authors.initials: J
authors.lastname: Cui
authors.forename: Yongyu
authors.initials: Y
authors.lastname: Deng
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.forename: Huijie
authors.initials: H
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ma
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Hong
authors.forename: Zhanjiang
authors.initials: Z
authors.lastname: Li
authors.forename: Haisong
authors.initials: H
authors.lastname: Shi
authors.forename: David
authors.initials: D
authors.lastname: Shum
mesh_terms: D000328:Adult; D000368:Aged; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D018709:Statistics, Nonparametric