title: Occurrence and risk assessment of acidic pharmaceuticals in the Yellow River, Hai River and Liao River of north China.
abstract: Pharmaceuticals in the aquatic environment have received great attentions from the general and scientific community due to their potential impacts on ecological and human health. We investigated the occurrence of twelve acidic pharmaceuticals and herbicides (salicylic acid, clofibric acid, ibuprofen, gemfibrozil, fenoprofen, naproxen, ketoprofen, mefenamic acid, tolfenamic acid, diclofenac, meclofenamic acid and indomethacin) in surface waters of the Yellow River, Hai River and Liao River in north China during the wet and dry seasons and assessed the potential risks to aquatic organisms posed by these acidic compounds. Seven acidic compounds were detected in the rivers, including five non-steroidal anti-inflammatory drugs (salicylic acid, ibuprofen, diclofenac, mefenamic acid and naproxen), and two blood lipid regulators (clofibric acid and gemfibrozil). The concentrations for acidic pharmaceuticals in the Yellow River and Liao River were in most cases higher in the dry season than in the wet season, but the concentrations of acidic compounds in the Hai River were generally higher in July than in November. High concentrations of these detected compounds in the Yellow River, Hai River and Liao River were found more frequently at those sites located in metropolitan areas, lower reaches or river confluences. Only diclofenac and ibuprofen were found to have medium to high risks in the three rivers based on the calculated risk quotients.
authors.affiliation: State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Guang-Guo
authors.initials: GG
authors.lastname: Ying
authors.forename: Jian-Liang
authors.initials: JL
authors.lastname: Zhao
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhou
mesh_terms: D002681:China; D005618:Fresh Water; D004364:Pharmaceutical Preparations / Q000032:analysis*; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical