Osteoporosis and inflammation.
Several inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, celiac disease, cystic fibrosis and chronic obstructive pulmonary disease have been associated to bone resorption. The link between osteoclast, macrophage colony stimulating factor and pro-inflammatory cytokines, especially tumor necrosis factor-alpha and interleukin-1 explain the association between inflammation and osteoporosis. These diseases are related to osteoporosis and high fracture risk independent of other risk factors common to inflammatory diseases such as reduced physical activity, poor nutritional status, hypovitaminosis D, decrease in calcium intake and glucocorticoid treatment. Erythrocyte sedimentation rate and C-reactive protein should always be performed, but the indication about when to perform the densitometry test should be analyzed for each disease. Bisphosphonates are nowadays the best choice of therapy but new medications such as denosumab, IL-1 receptor antagonist, and TNF-alpha antibody have risen as new potential treatments for osteoporosis secondary to inflammation.
Lacativa
Paulo Gustavo Sampaio
PG
Departamento de Medicina Interna, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, RJ, Brasil. pglaca@yahoo.com <pglaca@yahoo.com>
Farias
Maria Lucia Fleiuss de
ML
D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D004164:Diphosphonates / Q000627:therapeutic use; D050723:Fractures, Bone; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D010010:Osteoclasts / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*
D004164:Diphosphonates