Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment.
OBJECTIVE
To investigate associations of the Mediterranean diet (MeDi) components and the MeDi score with mild cognitive impairment (MCI).


METHODS
Participants (aged 70-89 years) were clinically evaluated to assess MCI and dementia, and completed a 128-item food frequency questionnaire.


RESULTS
163 of 1,233 nondemented persons had MCI. The odds ratio of MCI was reduced for high vegetable intake [0.66 (95% CI = 0.44-0.99), p = 0.05] and for high mono- plus polyunsaturated fatty acid to saturated fatty acid ratio [0.52 (95% CI = 0.33-0.81), p = 0.007], adjusted for confounders. The risk of incident MCI or dementia was reduced in subjects with a high MeDi score [hazard ratio = 0.75 (95% CI = 0.46-1.21), p = 0.24].


CONCLUSIONS
Vegetables, unsaturated fats, and a high MeDi score may be beneficial to cognitive function.
Roberts
Rosebud O
RO
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA. roberts.rosebud @ mayo.edu
Geda
Yonas E
YE
Cerhan
James R
JR
Knopman
David S
DS
Cha
Ruth H
RH
Christianson
Teresa J H
TJ
Pankratz
V Shane
VS
Ivnik
Robert J
RJ
Boeve
Bradley F
BF
O'Connor
Helen M
HM
Petersen
Ronald C
RC
D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000523:psychology*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000523:psychology*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology / Q000523:psychology; D004034:Diet Surveys; D038441:Diet, Mediterranean; D005224:Fats, Unsaturated; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D009518:New York / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires; D014675:Vegetables
D005224:Fats, Unsaturated