Skull base metastasis from follicular thyroid carcinoma -two case reports-.
A 58-year-old woman and a 71-year-old woman presented with extremely rare skull base metastases from follicular thyroid carcinoma (FTC). Surgical removal and external radiotherapy were performed followed by iodine-131 ((131)I) brachytherapy and thyroid hormone administration. The metastatic tumors in the skull base were well controlled. Treatment for skull base metastasis from FTC includes surgical debulking of the metastatic lesion, as well as complete resection of the thyroid gland, followed by internal irradiation with (131)I, external irradiation, and administration of thyroid hormone to prevent tumor growth by suppression of endogenous thyroid-stimulating hormone. Skull base metastases may be the initial clinical presentation of FTC, with silent primary sites. The possibility of skull base metastasis from FTC should be considered in patients with clinical symptoms of cranial nerve dysfunction and radiological findings of bone destruction.
Matsuno
Akira
A
Department of Neurosurgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan. akirakun@med.teikyo-u.ac.jp
Katakami
Hideki
H
Okazaki
Ryo
R
Yamada
So
S
Sasaki
Mitsuyoshi
M
Nakaguchi
Hiroshi
H
Yamada
Shoko M
SM
Hoya
Katsumi
K
Murakami
Mineko
M
Yamazaki
Kazuto
K
Ishida
Yasuo
Y
Iwasaki
Hiroyuki
H
Kuyama
Jyunpei
J
Kakudo
Kennichi
K
D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001918:Brachytherapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008875:Middle Aged; D011859:Radiography; D035583:Rare Diseases; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D013963:Thyroid Hormones / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D007457:Iodine Radioisotopes; D013963:Thyroid Hormones