title: Synthesis of densely substituted trans-configured 4-acylated piperidine-2,4-diones as 3:1 adducts of imines and ketenes.
abstract: An operationally simple method is described to form densely substituted diastereomerically pure trans-configured and potentially biologically interesting 5,6-dihydropyridone derivatives as 3:1 adducts of ketenes formed in situ from acyl bromides and aromatic imines.
authors.affiliation: Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany.
authors.forename: José
authors.initials: J
authors.lastname: Cabrera
authors.forename: Tina
authors.initials: T
authors.lastname: Hellmuth
authors.forename: René
authors.initials: R
authors.lastname: Peters