title: Plerixafor (Mozobil) for stem cell mobilization in patients with multiple myeloma previously treated with lenalidomide.
abstract: Lenalidomide and other new agents have considerable activity in multiple myeloma (MM) and have changed the landscape of treatment. Data suggest that lenalidomide therapy before autologous hematopoietic stem cell transplantation has a detrimental effect on stem cell mobilization. This retrospective study examined the efficacy of plerixafor in combination with G-CSF among patients with MM previously treated with lenalidomide (median, 4 cycles; range, 1-20 cycles). Data were analyzed for 60 patients who received plerixafor plus G-CSF for frontline mobilization in a phase 3 clinical trial or an expanded access program (n=20) or for remobilization in a compassionate use program (n=40). The overall median number of CD34+ cells collected was 5.6 × 10(6) per kg (range, 0.45 × 10(6)-37.2 × 10(6)). The minimum number of CD34+ cells (2 × 10(6) per kg) was collected from 86.7% of patients in a median of 1 day. This minimum was collected from 100% of patients who underwent frontline mobilization and 80% of patients who underwent remobilization. These data suggest that CD34+ hematopoietic stem cells can be successfully and predictably collected with combination plerixafor plus G-CSF for primary or secondary mobilization in the majority of patients with MM who have been previously treated with lenalidomide.
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA. Micallef.Ivana@mayo.edu
authors.forename: I N M
authors.initials: IN
authors.lastname: Micallef
authors.forename: A D
authors.initials: AD
authors.lastname: Ho
authors.forename: L M
authors.initials: LM
authors.lastname: Klein
authors.forename: S
authors.initials: S
authors.lastname: Marulkar
authors.forename: P J
authors.initials: PJ
authors.lastname: Gandhi
authors.forename: G
authors.initials: G
authors.lastname: Calandra
authors.forename: P A
authors.initials: PA
authors.lastname: McSweeney
mesh_terms: D018952:Antigens, CD34 / Q000096:biosynthesis; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001596:Benzylamines; D001781:Blood Component Removal; D000080027:Cyclams; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; D013792:Thalidomide; D000077269:Lenalidomide; C088327:plerixafor