Neonatal undernutrition may affect the delivery of sulfatides from perikarya of oligodendrocytes and golgi-related membranes.
Brain slices obtained from 18-day old normal and undernourished animals, incubated in the presence of [(35)]sulfate, were used to explore the delivery of sulfatides from oligodendroglial cell perikarya and from microsomal subfractions and their further incorporation into myelin. The results obtained in normal animals indicate the existence of a precursor-product relationship between the sulfatides of oligodendroglial cell perikarya and myelin sulfatides and a similar relationship among the sulfatides of Golgi enriched membranes and those of myelin. The presence of such relationship is also supported by the results obtained in undernourished rats in which there is a failure in the delivery of sulfatides from the perikarya of the oligodendroglial cells and from the fraction rich in Golgi membranes coincident with a decrease in the appearance of these lipids at the level of the myelin membrane.
Sato
C
C
Programa de Investigación en Neuroquímica (PRINEUQUI), CONICET, Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina.
Larocca
J N
JN
Pasquini
J M
JM
Soto
E F
EF