[On a hypothetic model based on the involvement of the immune system in the cells proliferation and metastasization of tumors].
Tumor cells lose their capability of self-destruction at the hazard of their transformation; they are actually immortal. The macrophages phagocyting the oncogenous cell (its nucleus or fragment) may not manage to destroy it. Under such conditions, the transformation of the macrophage itself into the oncogenous cell could not be ruled out. In the present work, a new hypothesis for the participation of the immune system in the metastasization of tumors is proposed. The extensive investigation of this mechanism would help to find new ways of cancer forecast and treatment.
Sepiashvili
D P
DP
D049109:Cell Proliferation; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000276:immunology* / Q000473:pathology; D010586:Phagocytes / Q000276:immunology / Q000473:pathology*; D010587:Phagocytosis