title: Water extract of Houttuynia cordata Thunb. leaves exerts anti-obesity effects by inhibiting fatty acid and glycerol absorption.
abstract: Houttuynia cordata Thunb. is used in folk medicine for diuresis and detoxification. However, it has not yet been reported to have an anti-obesity effect. We found that the water extract of H. cordata leaves (WEH) inhibited the corn oil-induced increase in plasma triglyceride levels in mice. WEH also inhibited the oleic acid- and glycerol-induced increase in the levels of plasma nonesterified fatty acids and glycerol, respectively. Moreover, WEH had anti-obesity effects in mice with high-fat-diet-induced obesity. Therefore, WEH may be able to prevent or reduce obesity induced by a high-fat diet.
authors.affiliation: Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Miyata
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazunaga
authors.initials: K
authors.lastname: Yazawa
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005260:Female; D005990:Glycerol / Q000097:blood / Q000378:metabolism*; D052859:Houttuynia; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051379:Mice; D009765:Obesity / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D014867:Water
chemical_list: D004365:Drugs, Chinese Herbal; D005227:Fatty Acids; C442781:Houttuynia cordata extract; D014280:Triglycerides; D014867:Water; D005990:Glycerol