Serum nitrosative stress levels are increased in Alzheimer disease but not in vascular dementia.
The aim of this study was to investigate whether there is a difference between Alzheimer disease (AD) dementia and pure vascular dementia (VaD) in relation to nitrosative stress levels. We determined serum nitric oxide (NO), oxidized low-density lipoproteins (ox-LDL), and 3-nitrotyrosine levels (3-NT) in healthy elderly individuals (controls, n=15, mean age=73.4+/-7.9 y), AD patients (n=30; mean age=71.2+/-12.7 y) and VaD patients (n=20; mean age=75.2+/-7.5 y). Patients were under anticholinesterase drug therapy. Our results showed that serum NO and ox-LDL levels in AD patients group were significantly higher than in both controls (P<0.001 and P<0.001) and VaD patients (P<0.01 and P<0.001). However, no significant differences in plasma NO and ox-LDL levels were found between VaD and controls. Our study did not reveal significant differences in plasma 3-NT values of dementia patients when compared with controls. There was a significant negative correlation between Mini-Mental State Examination score and serum NO levels in dementia patients (r=-0.349, P<0.01). Serum NO levels were also positively correlated with serum ox-LDL levels (r=0.358, P<0.01). In conclusion, elevation in serum levels of NO was present in probable AD patients but not in VaD patients, and this seems to be related to both ox-LDL levels and cognitive status.
Dildar
Konukoğlu
K
Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. dkonuk@istanbul.edu.tr
Sinem
Firtina
F
Gökhan
Erkol
E
Orhan
Yağiz
Y
Filiz
Manga
M
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D015140:Dementia, Vascular / Q000097:blood*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D009483:Neuropsychological Tests; D009569:Nitric Oxide / Q000097:blood*; D009603:Nitroso Compounds / Q000097:blood*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood
C443112:3-nitrosotyrosine; D008077:Lipoproteins, LDL; D009603:Nitroso Compounds; C099252:oxidized low density lipoprotein; D009569:Nitric Oxide; D014443:Tyrosine