title: Adenosine binding sites in brain; relationship to endogenous levels of adenosine and to its physiological and regulatory roles.
abstract: Adenosine is an endogenous component of brain tissue and is present at micromolar concentrations, well above those required to saturate the adenylate cyclase-linked receptors recently demonstrated by binding studies. It is suggested that a major binding site for adenosine may be the enzyme S-adenosyl homocysteinase, and modulation of the equilibrium catalysed by this reaction may regulate the concentration of adenosine available for stimulation of cyclic AMP production and its other physiological roles.
authors.affiliation: Dept. of Research, Jerusalem Mental Health Center, Ezrath Nashim Hospital, P.O.B. 140, Jerusalem Israel.
authors.forename: M E
authors.initials: ME
authors.lastname: Newman