Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli: a case for EspB as an intrinsically less-ordered effector.
Enterohemorrhagic and enteropathogenic Escherichia coli produce various effector proteins that are directly injected into the host-cell cytosol through the type III secretion system. E. coli secreted protein (Esp)B is one such effector protein, and affects host-cell morphology by reorganizing actin networks. Unlike most globular proteins that have well-ordered, rigid structures, the structures of type III secretion system effectors from pathogenic Gram-negative bacteria, including EspB, are often less well-ordered. This minireview focuses on the functional relationship between the structural properties of these proteins and their roles in type III secretion system-associated pathogenesis.
Hamada
Daizo
D
Division of Structural Biology (G-COE), Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Kobe University, Chuo-ku, Kobe, Japan. daizo@med.kobe-u.ac.jp
Hamaguchi
Mitsuhide
M
Suzuki
Kayo N
KN
Sakata
Ikuhiro
I
Yanagihara
Itaru
I
D000199:Actins / Q000502:physiology; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D003599:Cytoskeleton / Q000382:microbiology* / Q000473:pathology; D054324:Enterohemorrhagic Escherichia coli / Q000472:pathogenicity*; D054308:Enteropathogenic Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000503:physiopathology; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D017510:Protein Folding; D012760:Shigella / Q000502:physiology; D015398:Signal Transduction; D013056:Spectrophotometry, Ultraviolet; D014774:Virulence
D000199:Actins; D001425:Bacterial Outer Membrane Proteins; C087863:EaeB protein, E coli; D029968:Escherichia coli Proteins