title: [Value of tumor markers in the cerebrospinal fluid in the diagnosis of meningeal carcinomatosis].
abstract: OBJECTIVE
  To assess the diagnostic value of tumor markers in the cerebrospinal fluid (CSF) for meningeal carcinomatosis (MC).
  
  
  METHODS
  Twenty-one MC patients (including 13 adenocarcinoma and 8 non-adenocarcinoma patients), 72 patients with tuberculous meningitis (TBM) and 23 with primary intracerebral tumors (PIT) were enrolled in this study. Blood and CSF tumor markers including CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP and NSE were measured by Roche E170 electrochemiluminescence analyzer and sandwich assay.
  
  
  RESULTS
  CSF tumor markers CEA, CA125, CA199 and CYFRA21-1 and the serum tumor markers CEA, CA125, CA153, CA199 and AFP were significantly higher in MC group than in the other two groups. CSF CEA and CA15-3 were significantly higher in adenocarcinoma MC than in non-adenocarcinoma MC patients, but no significant differences were found in the serum tumor markers between the two groups (P>0.05). CSF tumor markers including CEA, CA125, CA15-3, CA72-4 and CYFRA21-1 were positively correlated to the serum tumor markers (P<0.05). CA199 was positively correlated to the disease course (P<0.05), and age was not correlated to any of the indexes (P>0.05).
  
  
  CONCLUSIONS
  Detection of the tumor markers in the CSF, especially CEA, CA125, CA19-9 and CYFRA21-1, may help in the early diagnosis of MC. CEA and CA15-3 can serve as indicators for differential diagnosis of adenocarcinoma and non-adenocarcinoma.
authors.affiliation: Department of Neurology, General Hospital of PLA, Beijing 100853, China. shiq301@sina.com
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shi
authors.forename: Chuan-qiang
authors.initials: CQ
authors.lastname: Pu
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Wu
authors.forename: Xu-sheng
authors.initials: XS
authors.lastname: Huang
authors.forename: Sheng-yuan
authors.initials: SY
authors.lastname: Yu
authors.forename: Cheng-lin
authors.initials: CL
authors.lastname: Tian
authors.forename: De-hui
authors.initials: DH
authors.lastname: Huang
authors.forename: Jia-tang
authors.initials: JT
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000134:cerebrospinal fluid / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000134:cerebrospinal fluid; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D018394:CA-125 Antigen / Q000134:cerebrospinal fluid; D018395:CA-19-9 Antigen / Q000134:cerebrospinal fluid; D002272:Carcinoembryonic Antigen / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D053539:Keratin-19 / Q000134:cerebrospinal fluid; D008297:Male; D008565:Membrane Proteins / Q000134:cerebrospinal fluid; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; C451759:MUC16 protein, human; D008565:Membrane Proteins; C102012:antigen CYFRA21.1