Analytical characterization of cell-asbestos fiber interactions in lung pathogenesis.
Asbestos is a fiber causing lung diseases such as asbestosis and mesothelioma. Although the process involving these diseases remains to be elucidated for developing drugs and treatments, direct consequences of fiber exposure in humans have been clearly demonstrated. These diseases are first characterized by histological heterogeneity and combine chronic inflammation with fibrosis and cellular alterations. As a consequence, asbestosis is usually diagnosed at advanced stages of the disease and treatments are usually inefficient to cure the patients. Here, we review the links established between asbestos fiber chemistry and morphology with the occurrence of associated lung diseases. Cytological and histological aspects of diseases are described with respect to current analytical capabilities, notably for microscopy techniques.
Yao
Seydou
S
Université de Bordeaux, CNRS UMR 5248, CBMN, 2 Rue Robert Escarpit, 33600 Pessac Cedex, France.
DellaVentura
Giancarlo
G
Petibois
Cyril
C
D001194:Asbestos / Q000009:adverse effects / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003584:Cytological Techniques; D006652:Histological Techniques; D006801:Humans; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology; D008853:Microscopy
D001194:Asbestos