Melt-in-mouth pellets of fexofenadine hydrochloride using crospovidone as an extrusion-spheronisation aid.
Microcrystalline cellulose (MCC) is well established as an extrusion spheronisation aid for the preparation of pellets. Crospovidone (Polyplasdone XL-10) is compared with microcrystalline cellulose for the preparation of melt-in-mouth pellets. Taste-masked fexofenadine hydrochloride was incorporated in the melt-in-mouth formulation. Crospovidone was found to be well suited as extrusion-spheronisation aid for the preparation of melt-in-mouth pellets. The great advantage of crospovidone is, however, the disintegrating properties of the pellets after only a short time of exposure to liquid. Crospovidone was successfully employed as an extrusion-spheronisation aid to produce melt-in-mouth pellets obviating the need of a traditional extrusion-spheronisation aid, MCC. Dual properties of Crospovidone were explored viz. as an extrusion-spheronisation aid and a disintegrant.
Jain
Satishkumar P
SP
Department Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, 400019, India.
Mehta
Dharmini C
DC
Shah
Sejal P
SP
Singh
Pirthi Pal
PP
Amin
Purnima D
PD
D000284:Administration, Oral; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000737:chemistry; D002214:Capsules; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D005079:Excipients / Q000138:chemical synthesis*; D009055:Mouth; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D016593:Terfenadine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry
D018926:Anti-Allergic Agents; D002214:Capsules; D005079:Excipients; D016593:Terfenadine; C093230:fexofenadine; D011205:Povidone