title: Effect of adiponectin and sex steroid hormones on bone mineral density and bone formation markers in postmenopausal women with subclinical hyperthyroidism.
abstract: OBJECTIVE
  The relationship between adiponectin and sex hormones with bone mineral density (BMD) and bone formation markers was investigated in postmenopausal women with subclinical hyperthyroidism (SCH).
  
  
  METHODS
  Seventy-five postmenopausal women were selected among the patients who participated in a health screening program in 2007. Thirty-seven control women with normal thyroid function were matched to 38 women with SCH by age, body mass index (BMI), and years since menopause (YSM). The associations between adiponectin and sex hormones with lumbar spine BMD and bone turnover markers were investigated.
  
  
  RESULTS
  Adiponectin, testosterone (T; total and free forms), and thyroid-stimulating hormone were significantly different between the women with SCH and euthyroid. After adjusting for age, BMI, and YSM, free T (r = 0.351; P = 0.029) and estradiol (E2; r = -0.368; P = 0.024) had significant associations with bone alkaline phosphatase (B-ALP). Total T (r = 0.388; P = 0.021) and E2 (r = -0.376; P = 0.026) had significant associations with osteocalcin. However, there were no significant associations between adiponectin and sex hormones with the BMD levels in the SCH subjects.
  
  
  CONCLUSIONS
  There were correlations between sex hormones with B-ALP and osteocalcin, but no associations between adiponectin and sex hormones with the lumbar spine BMD in postmenopausal SCH patients.
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
authors.forename: Ki Hoon
authors.initials: KH
authors.lastname: Ahn
authors.forename: Seung Hyeun
authors.initials: SH
authors.lastname: Lee
authors.forename: Hyun Tae
authors.initials: HT
authors.lastname: Park
authors.forename: Tak
authors.initials: T
authors.lastname: Kim
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Hur
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Sun Haeng
authors.initials: SH
authors.lastname: Kim
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000097:blood; D005260:Female; D006304:Health Status; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000503:physiopathology; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis / Q000502:physiology*; D017698:Postmenopause / Q000097:blood*; D012044:Regression Analysis; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood*; D013972:Thyrotropin / Q000097:blood
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D015675:Osteocalcin; D013739:Testosterone; D004958:Estradiol; D013972:Thyrotropin