title: Headache in thrombotic thrombocytopenic purpura: two cases with pathophysiological considerations.
abstract: Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.
authors.affiliation: Montefiore Medical Center-Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Bezov
authors.forename: Richard B
authors.initials: RB
authors.lastname: Lipton
authors.forename: Nikolai
authors.initials: N
authors.lastname: Podoltsev
authors.forename: Chi G
authors.initials: CG
authors.lastname: Zhao
authors.forename: Sait
authors.initials: S
authors.lastname: Ashina
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006261:Headache / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000503:physiopathology