title: Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy. marialaura.bolognesi@unibo.it
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Bolognesi
authors.forename: Manuela
authors.initials: M
authors.lastname: Bartolini
authors.forename: Francesca
authors.initials: F
authors.lastname: Mancini
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Chiriano
authors.forename: Luisa
authors.initials: L
authors.lastname: Ceccarini
authors.forename: Michela
authors.initials: M
authors.lastname: Rosini
authors.forename: Andrea
authors.initials: A
authors.lastname: Milelli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Tumiatti
authors.forename: Vincenza
authors.initials: V
authors.lastname: Andrisano
authors.forename: Carlo
authors.initials: C
authors.lastname: Melchiorre
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D001665:Binding Sites; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D008024:Ligands; D013619:Tacrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C122128:1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine; D000682:Amyloid; D002800:Cholinesterase Inhibitors; D008024:Ligands; D013619:Tacrine; D000110:Acetylcholinesterase; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human