[Hormones and hair growth].
With respect to the relationship between hormones and hair growth, the role of androgens for androgenetic alopecia (AGA) and hirsutism is best acknowledged. Accordingly, therapeutic strategies that intervene in androgen metabolism have been successfully developed for treatment of these conditions. Clinical observations of hair conditions involving hormones beyond the androgen horizon have determined their role in regulation of hair growth: estrogens, prolactin, thyroid hormone, cortisone, growth hormone (GH), and melatonin. Primary GH resistance is characterized by thin hair, while acromegaly may cause hypertrichosis. Hyperprolactinemia may cause hair loss and hirsutism. Partial synchronization of the hair cycle in anagen during late pregnancy points to an estrogen effect, while aromatase inhibitors cause hair loss. Hair loss in a causal relationship to thyroid disorders is well documented. In contrast to AGA, senescent alopecia affects the hair in a diffuse manner. The question arises, whether the hypothesis that a causal relationship exists between the age-related reduction of circulating hormones and organ function also applies to hair and the aging of hair.
Trüeb
R M
RM
Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, 8091, Zürich, Switzerland. ralph.trueeb@usz.ch
D000172:Acromegaly / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000505:Alopecia / Q000503:physiopathology; D001141:Aromatase / Q000502:physiology; D042944:Cholestenone 5 alpha-Reductase / Q000502:physiology; D005260:Female; D006197:Hair / Q000254:growth & development*; D006628:Hirsutism / Q000503:physiopathology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology; D007006:Hypogonadism / Q000503:physiopathology; D007037:Hypothyroidism / Q000503:physiopathology; D046150:Laron Syndrome / Q000503:physiopathology; D008297:Male; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D011247:Pregnancy; D012737:Sex Factors; D055815:Young Adult
D006728:Hormones; D001141:Aromatase; D042944:Cholestenone 5 alpha-Reductase