title: The effects of amantadine on liposomally reconstituted nicotinic acetylcholine receptor.
abstract: The effects of amantadine on liposomally reconstituted nicotinic acetylcholine receptor function were studied. At 1 x 10(?4)M, the drug blocked 85% of the carbamylcholine-induced cation influx into liposomes, but left 90% of the ?bungarotoxin binding intact. In addition, amantadine was shown to be a non-competitive inhibitor of membrane bound acetylcholinesterase. These experiments are relevant to the mechanism of action of amantadine at the motor end plate, where it produces electrophysiological changes compatible with an inhibition of cholinergic agonist mediated ion flux.
authors.affiliation: Instituto de Biología Celular, Facultad de Medicina, (1121) CF, Buenos Aires, Argentina.
authors.forename: E L
authors.initials: EL
authors.lastname: Ochoa