[Effects of etomidate infusion on serum cortisol in patients undergoing radical resection of lung cancer].
OBJECTIVE
To evaluate the effect of etodimate infusion on serum cortisol in patients undergoing radical resection of lung cancer operations during the perioperative period.


METHODS
Forty ASA I-II patients undergoing radical resection of lung cancer were randomly divided into etomidate group (Group E) and propofol group (Group P) (n=20). The serum cortisol was measured at 8:00 am (T(0)) before anesthesia, 4:00 pm (T(1)) on the day of operation and 24 h after the operation (T(2)) by radioimmunoassay.


RESULTS
Compared with that at T0, the serum level of cortisol significantly increased at 24 h after the operation in both groups (P<0.01); serum cortisol decreased lightly at T1, which was not statistically significant (P>0.05), and remained higher than the normal level. At each of the time points, serum cortisol levels were comparable between the two groups (P>0.05).


CONCLUSIONS
Etomidate infusion can not inhibit the synthesis of cortisol in patients undergoing radical resection of lung cancer.
Xie
Yong-qiu
YQ
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. yongqiuxie@yahoo.com.cn
Jiao
He-na
HN
Guo
Qu-lian
QL
Cheng
Chan
C
D000328:Adult; D000768:Anesthesia, General; D005045:Etomidate / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods; D011184:Postoperative Period; D055815:Young Adult
D006854:Hydrocortisone; D005045:Etomidate