title: Sonication, calcium, and peptides have systematic effects on the nonlinear dynamics of tyrosine hydroxylase activity.
abstract: Sonication, dialysis, calcium, and peptides have systematic effects on the nonlinear dynamics of tyrosine hydroxylase (TOH). Under standard assay conditions TOH shows a high amplitude fluctuation in catalytic output across time that is eliminated either by sonication or by dialysis. This coherent dynamic is restored with the addition to the dialyzed preparation of either calcium in micromolar concentrations or certain peptides (SOM, MSH), but not others (CCK, TRH).
authors.affiliation: Department of Psychiatry (M-003), University of California, San Diego, La Jolla, California 92093, U.S.A.
authors.forename: P V
authors.initials: PV
authors.lastname: Russo
authors.forename: A J
authors.initials: AJ
authors.lastname: Mandell