title: Association of obstructive sleep apnea risk with asthma control in adults.
abstract: BACKGROUND
  Unrecognized obstructive sleep apnea (OSA) may lead to poor asthma control despite optimal therapy. Our objective was to evaluate the relationship between OSA risk and asthma control in adults.
  
  
  METHODS
  Patients with asthma seen routinely at tertiary-care clinic visits completed the validated Sleep Apnea Scale of the Sleep Disorders Questionnaire (SA-SDQ) and Asthma Control Questionnaire (ACQ). An ACQ score of >or= 1.5 defined not-well-controlled asthma, and an SA-SDQ score of >or= 36 for men and >or= 32 for women defined high OSA risk. Logistic regression was used to model associations of high OSA risk with not-well-controlled asthma (ACQ full version and short versions).
  
  
  RESULTS
  Among 472 subjects with asthma, the mean +/- SD ACQ (full version) score was 0.87 +/- 0.90, and 80 (17%) subjects were not well controlled. Mean SA-SDQ score was 27 +/- 7, and 109 (23%) subjects met the definition of high OSA risk. High OSA risk was associated, on average, with 2.87-times higher odds for not-well-controlled asthma (ACQ full version) (95% CI, 1.54-5.32; P = .0009) after adjusting for obesity and other factors known to worsen asthma control. Similar independent associations were seen when using the short ACQ versions.
  
  
  CONCLUSIONS
  High OSA risk is significantly associated with not-well-controlled asthma independent of known asthma aggravators and regardless of the ACQ version used. Patients who have difficulty achieving adequate asthma control should be screened for OSA.
authors.affiliation: Medical Service, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. mt3@medicine.wisc.edu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Teodorescu
authors.forename: David A
authors.initials: DA
authors.lastname: Polomis
authors.forename: Stephanie V
authors.initials: SV
authors.lastname: Hall
authors.forename: Mihai C
authors.initials: MC
authors.lastname: Teodorescu
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gangnon
authors.forename: Andrea G
authors.initials: AG
authors.lastname: Peterson
authors.forename: Ailiang
authors.initials: A
authors.lastname: Xie
authors.forename: Christine A
authors.initials: CA
authors.lastname: Sorkness
authors.forename: Nizar N
authors.initials: NN
authors.lastname: Jarjour
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control*; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D019141:Respiratory System Agents / Q000627:therapeutic use; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D055815:Young Adult
chemical_list: D019141:Respiratory System Agents