title: Electrochemotherapy treatment for bilateral pleomorphic rhabdomyosarcoma in a cat.
abstract: A 13-year-old male neutered cat was presented for the sudden growth of two nodular lesions close to the upper eyelid of both eyes. Fine-needle aspiration cytology was suggestive of mesenchymal neoplasia. The cat had conservative surgical excision in order to preserve the eyelids' functionality; however, the histopathological report came with a diagnosis of incompletely excised bilateral pleomorphic rhabdomyosarcoma. Due to the local aggressiveness of this neoplasm, the cat was treated with two sessions of cisplatin-based electrochemotherapy, delivered 14 days apart. Systemic or local toxicities were not detected during the whole course of therapy. The cat is still in complete remission after 12 months. Electrochemotherapy is a safe and efficacious adjuvant therapy for aggressive sarcomas and warrants further investigations in order to standardise its protocols.
authors.affiliation: S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy.
authors.forename: E P
authors.initials: EP
authors.lastname: Spugnini
authors.forename: M
authors.initials: M
authors.lastname: Filipponi
authors.forename: L
authors.initials: L
authors.lastname: Romani
authors.forename: I
authors.initials: I
authors.lastname: Dotsinsky
authors.forename: N
authors.initials: N
authors.lastname: Mudrov
authors.forename: G
authors.initials: G
authors.lastname: Citro
authors.forename: A
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000601:surgery; D002415:Cats; D003131:Combined Modality Therapy / Q000662:veterinary; D053672:Electrochemotherapy / Q000662:veterinary*; D005142:Eyelid Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D008297:Male; D012074:Remission Induction; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D016896:Treatment Outcome