title: Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma.
abstract: Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeneous group of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia overwhelmingly predominates the AHNMD component, lymphoproliferative disorders rarely occur as an AHNMD component of SM-AHNMD. Here we report two cases of SM-AHNMD, in which the AHNMD component is chronic lymphocytic leukemia in one case, and concurrent chronic lymphocytic leukemia as well as plasma cell myeloma in another case. To the best of our knowledge, this is the first case report of SM-AHNMD with chronic lymphocytic leukemia and plasma cell dyscrasia simultaneously.
authors.affiliation: Department of Pathology, University of California San Diego Moores Cancer Center, La Jolla, CA 92093-0987, USA.
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
authors.forename: Hooman H
authors.initials: HH
authors.lastname: Rashidi
authors.forename: Dzung T
authors.initials: DT
authors.lastname: Le
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kipps
authors.forename: H Elizabeth
authors.initials: HE
authors.lastname: Broome
authors.forename: Huan-You
authors.initials: HY
authors.lastname: Wang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002469:Cell Separation; D004252:DNA Mutational Analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008415:Mastocytosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
chemical_list: D019009:Proto-Oncogene Proteins c-kit