Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation.
BACKGROUND
Prematurity and small-for-gestational age (SGA) neonates are at risk for postnatal complications. Concentrations of total homocysteine (tHcy) might be related to neonatal outcome. We hypothesized that concentrations of tHcy are not related to growth restriction in neonates from mothers receiving 5 mg/day folic acid. We studied a total of 133 preterm neonates from normotensive mothers; SGA (n=96) and appropriate-for-gestational age (AGA, n=37).


METHODS
Concentrations of tHcy, folate and vitamin B12 were measured in venous umbilical cord plasma.


RESULTS
AGA preterm neonates had higher mean birth weight (BW) compared to SGA preterms (2472 g vs. 2007 g; p<0.001) of comparable mean gestational age (GA) (35.1 vs. 35.7 weeks; p=0.059). Concentrations of tHcy (4.86 vs. 4.95 micromol/L), folate (63.3 vs. 55.7 nmol/L), and vitamin B12 (409 vs. 394 pmol/L) were not significantly different between the groups. GA was a strong positive predictor, BW was a significant negative predictor of cord plasma folate. Vitamin B12 concentration was a significant negative predictor of cord tHcy.


CONCLUSIONS
Concentrations of tHcy did not differ between SGA and AGA preterm neonates born to mothers supplemented with folic acid. This finding argues against a causal role for folate deficiency or increased tHcy in growth restriction.
Gomes
Thushari S
TS
Department of General Pediatrics and Neonatology, University Children's Hospital, Faculty of Medicine, Saarland University, Homburg/Saar, Germany. Thushari.Gomes@uniklinikum-saarland.de
Lindner
Ulrike
U
Tennekoon
Kamani H
KH
Karandagoda
Wimal
W
Gortner
Ludwig
L
Obeid
Rima
R
D000328:Adult; D001724:Birth Weight; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005317:Fetal Growth Retardation / Q000209:etiology; D005492:Folic Acid / Q000032:analysis / Q000627:therapeutic use*; D005494:Folic Acid Deficiency / Q000188:drug therapy; D005865:Gestational Age; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D009035:Mothers; D011237:Predictive Value of Tests; D011247:Pregnancy; D047928:Premature Birth; D014805:Vitamin B 12 / Q000032:analysis
D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12