Synthesis of poly(p-dioxanone) catalyzed by Zn L-lactate under microwave irradiation and its application in ibuprofen delivery.
Microwave-assisted ring-opening polymerization (ROP) of p-dioxanone (PDO) catalyzed by Zn L-lactate (Znlac(2)) was investigated and the purified product was characterized by (1)H-NMR. When the ROP of PDO was carried out at 100 degrees C for 6.5 h, the viscosity-average molecular weight (M(v)) of poly(p-dioxanone) (PPDO) reached 53.2 kg/mol. The kinetics of ring-opening polymerization of PDO under microwave irradiation were investigated and the polymerization reaction was accurately first-order with respect to monomer concentration. The reaction rate was greatly accelerated by microwave irradiation, compared with conventional heating. The resultant PPDO was used as carrier and drug-release systems were prepared using ibuprofen (IBU) as model drug with 10, 15 and 20% loading. The release behavior of the systems was investigated in phosphate buffer solution at 37 degrees C and the release of IBU from the system was sustained and steady. The resultant PPDO could be well used as the carrier for the delivery drug.
Wang
Xiu-Li
XL
Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, P. R. China.
Chen
Yu-Yan
YY
Wang
Yu-Zhong
YZ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002384:Catalysis; D004146:Dioxanes / Q000138:chemical synthesis*; D004337:Drug Carriers / Q000138:chemical synthesis*; D007052:Ibuprofen / Q000008:administration & dosage*; D019344:Lactic Acid / Q000737:chemistry; D008872:Microwaves; D011108:Polymers / Q000138:chemical synthesis*; D015032:Zinc / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004146:Dioxanes; D004337:Drug Carriers; D011108:Polymers; C079733:poly-4-dioxan-2-one; D019344:Lactic Acid; D015032:Zinc; D007052:Ibuprofen