Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria.
Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 microg/mL.
Pruksakorn
Patamaporn
P
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Arai
Masayoshi
M
Kotoku
Naoyuki
N
Vilchèze
Catherine
C
Baughn
Anthony D
AD
Moodley
Prashini
P
Jacobs
William R
WR
Kobayashi
Motomasa
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents; D006801:Humans; D055666:Lipopeptides / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects* / Q000254:growth & development; D009163:Mycobacterium bovis / Q000187:drug effects; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011161:Porifera / Q000382:microbiology; D014242:Trichoderma / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D055666:Lipopeptides; C551822:trichoderin A; C551823:trichoderin A1; C551824:trichoderin B