title: Dyspepsia and irritable bowel syndrome in China: a population-based endoscopy study of prevalence and impact.
abstract: BACKGROUND
  Dyspepsia and irritable bowel syndrome (IBS) are common in Western populations.
  
  
  OBJECTIVE
  To determine the epidemiology of dyspepsia and IBS in China.
  
  
  METHODS
  A representative sample of 18 000 adults from five regions of China were asked to complete the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form Health Survey (SF-36). Participants from Shanghai were invited to provide blood samples and undergo oesophago-gastroduodenoscopy. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined using a multivariate logistic regression model.
  
  
  RESULTS
  The survey was completed by 16 091 individuals (response rate: 89.4%). Overall, 387 participants (2.4%) had dyspepsia and 735 (4.6%) had IBS. All SF-36 dimension scores were at least five points lower in individuals with than without dyspepsia or IBS (P < or = 0.001). In Shanghai, 1030 (32.7%) of the 3153 respondents agreed to endoscopy; neither dyspepsia nor IBS was found to be associated with reflux oesophagitis, peptic ulcer disease or Helicobacter pylori infection.
  
  
  CONCLUSIONS
  Prevalence estimates for dyspepsia and IBS in China are lower than in Western populations. In China, dyspepsia or IBS symptoms are generally not associated with underlying organic disease.
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: D
authors.initials: D
authors.lastname: Zou
authors.forename: R
authors.initials: R
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Man
authors.forename: L
authors.initials: L
authors.lastname: Gao
authors.forename: J
authors.initials: J
authors.lastname: Fang
authors.forename: H
authors.initials: H
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Kang
authors.forename: P
authors.initials: P
authors.lastname: Yin
authors.forename: Y
authors.initials: Y
authors.lastname: Hao
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Dent
authors.forename: J
authors.initials: J
authors.lastname: Sung
authors.forename: K
authors.initials: K
authors.lastname: Halling
authors.forename: B
authors.initials: B
authors.lastname: Wernersson
authors.forename: S
authors.initials: S
authors.lastname: Johansson
authors.forename: J
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004415:Dyspepsia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D004724:Endoscopy; D005260:Female; D006304:Health Status; D016481:Helicobacter Infections / Q000453:epidemiology; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D011788:Quality of Life; D011795:Surveys and Questionnaires