title: Missing pieces in the Parkinson's disease puzzle.
abstract: Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.
authors.affiliation: Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, Center for Applied Medical Research, Pamplona, Spain. obeso@unav.es
authors.forename: Jose A
authors.initials: JA
authors.lastname: Obeso
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rodriguez-Oroz
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Goetz
authors.forename: Concepcion
authors.initials: C
authors.lastname: Marin
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Kordower
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Etienne C
authors.initials: EC
authors.lastname: Hirsch
authors.forename: Matthew
authors.initials: M
authors.lastname: Farrer
authors.forename: Anthony H V
authors.initials: AH
authors.lastname: Schapira
authors.forename: Glenda
authors.initials: G
authors.lastname: Halliday
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D013378:Substantia Nigra / Q000503:physiopathology