title: Sinus opacification associated with exacerbation of thyroid eye disease.
abstract: OBJECTIVE
  To describe the association of sinus opacification with exacerbation of thyroid eye disease. Three cases followed orbital decompression performed when disease was quiescent and one case occurred without prior orbital or sinus surgery.
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  Four patients' charts were retrospectively reviewed.
  
  
  RESULTS
  Three patients with thyroid eye disease (TED), whose ophthalmopathy was stable after orbital decompression surgery, experienced recurrence of TED signs and symptoms after development of sinus inflammation. The fourth patient with TED did not have orbital surgery but presented with unilateral ophthalmopathy and ipsilateral sinus opacification.
  
  
  CONCLUSIONS
  Paranasal sinus disease can exacerbate TED, possibly through a nonspecific inflammatory response. Minimizing inflammation proximal to the orbit may afford some protection against progression of the orbital process occurring in TED.
authors.affiliation: Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, and University of Rochester Eye Institute, Rochester, New York 14642, USA.
authors.forename: Azin
authors.initials: A
authors.lastname: Abazari
authors.forename: Garrick
authors.initials: G
authors.lastname: Chak
authors.forename: Steven E
authors.initials: SE
authors.lastname: Feldon
mesh_terms: D000328:Adult; D019299:Decompression, Surgical; D005260:Female; D049970:Graves Ophthalmopathy / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000503:physiopathology*; D008875:Middle Aged; D010254:Paranasal Sinus Diseases / Q000503:physiopathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed