title: Synthesis of a novel biodegradable polyurethane with phosphatidylcholines.
abstract: A novel polyurethane was successfully synthesized by chain-extension of biodegradable poly (l-lactide) functionalized phosphatidylcholine (PC) with hexamethylene diisocyanate (HDI) as chain extender (PUR-PC). The molecular weights, glass transition temperature (Tg) increased significantly after the chain-extension. The hydrophilicity of PUR-PC was better than the one without PC, according to a water absorption test. Moreover, the number of adhesive platelets and anamorphic platelets on PUR-PC film were both less than those on PUR film. These preliminary results suggest that this novel polyurethane might be a better scaffold than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility. Besides, this study also provides a new method to prepare PC-modified biodegradable polyurethanes.
authors.affiliation: Sichuan University, Chengdu, China. caojun198610301981@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Niancao
authors.initials: N
authors.lastname: Chen
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Xianglin
authors.initials: X
authors.lastname: Luo
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001673:Biodegradation, Environmental; D057927:Hydrophobic and Hydrophilic Interactions; D010713:Phosphatidylcholines / Q000737:chemistry*; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D023822:Tissue Engineering; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D010713:Phosphatidylcholines; D011140:Polyurethanes; D014867:Water