Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids.
Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.
Sornosa-Ten
Alejandra
A
Departament de Química Inorgànica, ICMol, Facultat de Química, Universitat de València, Burjassot, Spain.
Albelda
M Teresa
MT
Frías
Juan C
JC
García-España
Enrique
E
Llinares
José M
JM
Budimir
Ana
A
Piantanida
Ivo
I
D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D011522:Protons; D012996:Solutions / Q000737:chemistry; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D009696:Nucleic Acids; D009711:Nucleotides; D011073:Polyamines; D011522:Protons; D012996:Solutions; D014867:Water