IL-10 alters prolactin receptor activity emulating that during breast cancer.
Peripheral blood mononuclear cells (PBMC) of breast cancer patients show altered prolactin (PRL)-induced proinflammatory response and express short form of prolactin receptor (PRL-R), besides secreting elevated level of interleukin (IL)-10 than that of the normal counterparts. IL-10 depleted the functional long form of PRL-R mRNA and protein, expressed PRL-R (SF) mRNA and blocked the PRL response found in normal individuals, which could be a mechanism to suppress the proinflammatory immune responses during malignancy.
Paul
Sonali
S
Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, 99, Sarat Bose Road, Kolkata-700 026, West Bengal, India.
Biswas
Amlan
A
Sasmal
Krittika
K
Mukherjee
Subhadeep
S
Biswas
Tapas
T
Biswas
Ratna
R
D000328:Adult; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008875:Middle Aged; D011388:Prolactin / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011981:Receptors, Prolactin / Q000378:metabolism*
D012333:RNA, Messenger; D011981:Receptors, Prolactin; D016753:Interleukin-10; D011388:Prolactin