title: Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial.
abstract: BACKGROUND
  Serum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer.
  
  
  OBJECTIVE
  To determine whether serum adiponectin, leptin, C-peptide, and homocysteine are associated with fat, fiber, fruit and vegetable, flavonol, or dry bean intake and colorectal adenoma recurrence.
  
  
  METHODS
  Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (95% CI) for adenoma recurrence in 627 participants from the control arm of the Polyp Prevention Trial, a 4-year trial that examined the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence.
  
  
  RESULTS
  Serum concentrations of C-peptide and homocysteine were inversely related to fiber, fruit and vegetable, and flavonol intake and positively related to percentage of calories from fat (all P(trend) < or = 0.01). High homocysteine concentrations were associated with any (4th versus 1st quartile: OR, 2.26; 95% CI, 1.30-3.94) and more than one adenoma recurrence (OR, 2.11; 95% CI, 1.01-4.40). Individuals in the highest, versus lowest, tertile of serum leptin concentration had a decreased risk of advanced adenoma recurrence (OR, 0.22; 95% CI, 0.06-0.79).
  
  
  CONCLUSIONS
  Our results suggest that serum homocysteine may serve as an indicator of dietary exposure, including a low-fat and high-fiber, high-fruit and vegetable, and high-flavonol diet, as well as colorectal adenoma recurrence.
  
  
  CONCLUSIONS
  Discovering biomarkers that are both modifiable and can predict cancer risk is critical. We identified serum homocysteine as a novel indicator that is modified by diet and predicts risk of adenoma recurrence.
authors.affiliation: Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute (NCI), NIH, Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. gerd.bobe@oregonstate.edu
authors.forename: Gerd
authors.initials: G
authors.lastname: Bobe
authors.forename: Gwen
authors.initials: G
authors.lastname: Murphy
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Rogers
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Hance
authors.forename: Paul S
authors.initials: PS
authors.lastname: Albert
authors.forename: Adeyinka O
authors.initials: AO
authors.lastname: Laiyemo
authors.forename: Leah B
authors.initials: LB
authors.lastname: Sansbury
authors.forename: Elaine
authors.initials: E
authors.lastname: Lanza
authors.forename: Arthur
authors.initials: A
authors.lastname: Schatzkin
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Cross
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000517:prevention & control; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002096:C-Peptide / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000517:prevention & control; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology; D012008:Recurrence; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D002096:C-Peptide; D020738:Leptin; D006710:Homocysteine