Telomerase and chromosome end protection in vivo: the TPP1 connection.
In an article published in this issue of Developmental Cell, Maria Blasco's group shows that the telomere end-binding protein TPP1 is involved in both end protection and telomerase regulation in vivo. Importantly, they highlight the relevance of telomerase activity in highly proliferative tissues and in reprogramming of cells to induced pluripotency (iPS).
Gilson
Eric
E
Laboratoire de Biologie Moléculaire de la Cellule, Université de Lyon, CNRS UMR5239, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, F-69364 Lyon Cedex 07, France. Eric.Gilson@ens-lyon.fr
Teixeira
M Teresa
MT