title: Electrosprayed core-shell microspheres for protein delivery.
abstract: This communication describes a single-step electrospraying technique that generates core-shell microspheres (CSMs) with encapsulated protein as the core and an amphiphilic biodegradable polymer as the shell. The protein release profiles of the electrosprayed CSMs showed steady release kinetics over 3 weeks without a significant initial burst.
authors.affiliation: Materials Science Program, Department of Mechanical Engineering, University of Rochester, Rochester, New York 14627, USA. wuyiquan@me.rochester.edu
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Wu
authors.forename: I-Chien
authors.initials: IC
authors.lastname: Liao
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Kennedy
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Du
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Kam W
authors.initials: KW
authors.lastname: Leong
authors.forename: Robert L
authors.initials: RL
authors.lastname: Clark
mesh_terms: D007700:Kinetics; D008863:Microspheres; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
chemical_list: D011091:Polyesters; D011108:Polymers; D011506:Proteins; C016240:polycaprolactone