HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols.
An enantioseparation study of nitro-substituted aryloxyaminopropanols was performed using HPLC on a teicoplanin chiral stationary phase and TLC impregnated with L-aspartic and L-tartaric acid as chiral selectors. The type of substituent on the nitrogen in the hydrophilic part of molecule is essential for excellent separation by HPLC. L-aspartic acid seems to be a suitable chiral selector for enantioseparation by TLC.
Cizmáriková
R
R
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. cizmarikova@fpharm.uniba.sk
Bruchatá
K
K
Pastírová
Z
Z
Lehotay
J
J
Hrobonová
K
K
D001224:Aspartic Acid / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D009574:Nitro Compounds / Q000737:chemistry*; D011412:Propanolamines / Q000737:chemistry*; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry
D007202:Indicators and Reagents; D009574:Nitro Compounds; D011412:Propanolamines; D013644:Tartrates; D001224:Aspartic Acid; C029768:tartaric acid