title: B vitamins in the nervous system.
abstract: The coenzyme functions of the B vitamins in intermediatry metabolism are well established; nevertheless, for none of them is it possible to determine precisely the connection between the biochemical lesions associated with deficiency and the neurological consequences. Although there is convincing evidence of a neurospecific role for thiamin and other B vitamins, in no case has this role been adequately described. Similarly, the neurochemical sequelae of intoxication by massive amounts of vitamins (so-called mega-vitamin therapy or orthomolecular medicine) remain largely unexplained.
authors.affiliation: Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London W1P 7PN, U.K.
authors.forename: D A
authors.initials: DA
authors.lastname: Bender