Towards a more physiological approach in GABA binding.
Gamma-aminobutyric acid (GABA) mediates the postsynaptic inhibition via reversible binding to specific recognition (receptor) sites. Despite extensive research, the results from binding and functional response measurements remains controversial. It is suggested that controversies may partly result from the use of non-physiological buffer during the preparation and binding assay of the GABA receptor. To account for the positive cooperativity found in physiological medium, a hypothetical model of the GABA receptor is proposed as a tetramer of binding sites operating in a cooperative fashion.
Kardos
J
J
Laboratory of Pharmacodynamics, Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary.
Maderspach
K
K
Simonyi
M
M