title: Asymmetric synthesis of axially chiral 1-aryl-5,6,7,8-tetrahydroquinolines by cobalt-catalyzed [2 + 2 + 2] cycloaddition reaction of 1-aryl-1,7-octadiynes and nitriles.
abstract: The asymmetric synthesis of a range of axially chiral 2-arylpyridines by a cobalt-catalyzed [2 + 2 + 2] cycloaddition reaction is described. The use of a planar chiral (1-neomenthylindenyl)cobalt(COD) complex under photochemical conditions is the key for reacting the 1-naphthyldiynes with a range of differently functionalized nitriles, giving the enantiomeric atropoisomers with high chemical yields and enantiomeric excesses of up to 94% ee.
authors.affiliation: Leibniz-Institut für Katalyse e.V. (LIKAT) an der Universität Rostock, Albert-Einstein-Str. 29a, D-18059 Rostock, Germany. marko.hapke@catalysis.de
authors.forename: Marko
authors.initials: M
authors.lastname: Hapke
authors.forename: Karolin
authors.initials: K
authors.lastname: Kral
authors.forename: Christine
authors.initials: C
authors.lastname: Fischer
authors.forename: Anke
authors.initials: A
authors.lastname: Spannenberg
authors.forename: Andrey
authors.initials: A
authors.lastname: Gutnov
authors.forename: Dmitry
authors.initials: D
authors.lastname: Redkin
authors.forename: Barbara
authors.initials: B
authors.lastname: Heller