[The expression of interleukin-17 in blood and nasal tissue of patients with allergic rhinltis and nasal polyps].
OBJECTIVE
To study the expression of IL-17 in blood and nasal tissue of allergic rhinitis and nasal polyps, and to investigate the possible mechanism of IL-17 in the progress of allergic rhinitis and nasal polyps.


METHODS
There were 41 patients enrolled, including the patients with allergic rhinitis, nasal polyps and deviated nasal septum. The blood and nasal mucosa tissue or nasal polyps were collected in all the patients. The expression of IL-17 was measured by the methods of ELISA and immunohistochemisty, and the number of eosinophils and IL-17 positive cells was measured.


RESULTS
The IL-17 expression of nasal polyps was significantly elevated in the blood and nasal tissue, which was obviously correlated with the number of eosinophils infiltrated in nasal tissue. However, for the patients with allergic rhinitis, there was only apparent expression of IL-17 in nasal mucosa.


CONCLUSIONS
IL-17 plays an important role in the development of nasal polyps, but for allergic rhinitis, it needs further study as an potential important aspect of the pathogenesis.
Du
Jin-tao
JT
Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Ba
Luo
L
Shang
Ting-ting
TT
Liu
Ya-feng
YF
Wei
Da-peng
DP
An
Hui-min
HM
D000293:Adolescent; D000328:Adult; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D055815:Young Adult
D020381:Interleukin-17