title: Late solitary testicular metastasis from rectal cancer.
abstract: Isolated testicular metastasis from rectal cancer is rare. We describe the case of a patient who presented with a locally advanced rectal malignancy and underwent multimodality treatment with low anterior resection, postoperative radiotherapy and adjuvant chemotherapy. He developed a painless testicular nodule while on follow-up, five years after the diagnosis of primary rectal cancer. Histopathology and immunohistochemistry of orchidectomy specimen were compatible with a metastatic adenocarcinoma of rectal origin. We hypothesize that this phenomenon of isolated relapse in a sanctuary site could be due to the altered biology and pattern of metastasis as a result of effective adjuvant systemic chemotherapy. Treatment of late isolated relapse in the testis needs to be ascertained.
authors.affiliation: Ipswich Hospital NHS, United Kingdom.
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Venkitaraman
authors.forename: Mathew
authors.initials: M
authors.lastname: George
authors.forename: Suranga
authors.initials: S
authors.lastname: Weerasooriya
authors.forename: Sid
authors.initials: S
authors.lastname: Selva-Nayagam
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy; D000368:Aged; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000473:pathology* / Q000628:therapy; D013736:Testicular Neoplasms / Q000556:secondary*
chemical_list: D005472:Fluorouracil