Novel therapeutic approach to counter the recruitment of circulating endothelial progenitor cells to tumors.
Evaluation of: Shaked Y, Ciarrocchi A, Franco M et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313, 1785-1787 (2006). Recently gathered evidence indicates that bone marrow-derived circulating endothelial progenitor cells can contribute to tumor angiogenesis and the growth of certain tumors. The paper under evaluation presents a novel therapeutic approach that disrupts the recruitment of these cells by tumors, therefore facilitating the antitumor activity of chemotherapeutic agents.
Espinoza
Luis R
LR
LSU Health Sciences Center, Department of Internal Medicine, New Orleans, LA 70112-2822, USA. luisrolan@msn.com