title: Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus.
abstract: TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55.6% in OLP and 53.3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42.2% and 35.6%; 2.2% and 11.1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71.2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0.546) or allele frequency (p = 0.497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil.
authors.forename: Andreza
authors.initials: A
authors.lastname: Barkokebas
authors.forename: Alessandra
authors.initials: A
authors.lastname: de Albuquerque T Carvalho
authors.forename: Paulo Roberto Eleutério
authors.initials: PR
authors.lastname: de Souza
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
authors.forename: Guilherme Machado
authors.initials: GM
authors.lastname: Xavier
authors.forename: Camila Maria Beder
authors.initials: CM
authors.lastname: Ribeiro
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
authors.forename: Stephen Ross
authors.initials: SR
authors.lastname: Porter
authors.forename: Jair Carneiro
authors.initials: JC
authors.lastname: Leão
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D017676:Lichen Planus, Oral / Q000235:genetics*; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D014409:Tumor Necrosis Factor-alpha