title: Total synthesis of the proposed structure of iriomoteolide-1a.
abstract: The total synthesis of the proposed structure of iriomoteolide-1a has been accomplished via a Yamaguchi esterification and ring closing metathesis sequence between the C(7)-C(23) and newly synthesized Z-alkenoic acid C(1)-C(6) fragments. The spectral data of the synthetic 1, however, is at odds with data reported for the natural product, thus bringing into question the original structural assignment.
authors.affiliation: Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Ma
authors.forename: David A
authors.initials: DA
authors.lastname: Horne
mesh_terms: D004951:Esterification; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: D018942:Macrolides; C520799:iriomoteolide-1a