Anti-Candida property of a lignan glycoside derived from Styrax japonica S. et Z. via membrane-active mechanisms.
Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.
Park
Cana
C
School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, 702-701, Korea.
Woo
Eun-Rhan
ER
Lee
Dong Gun
DG
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000472:pathogenicity / Q000502:physiology*; D002177:Candidiasis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002462:Cell Membrane / Q000378:metabolism; D015169:Colony Count, Microbial; D004161:Diphenylhexatriene / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D005456:Fluorescent Dyes / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032362:Styrax
D000935:Antifungal Agents; D005456:Fluorescent Dyes; D005960:Glucosides; D017705:Lignans; D010936:Plant Extracts; C546201:fargesin-4-O-glucopyranoside; D004161:Diphenylhexatriene