The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes.
BACKGROUND
The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM.


METHODS
2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up.


RESULTS
NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during OGTT had greater insulin sensitivity, better beta cell function and lower risk for future T2DM.


CONCLUSIONS
These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM.
Abdul-Ghani
Muhammad A
MA
Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. abdulghani@uthscsa.edu
Lyssenko
Valeriya
V
Tuomi
Tiinamaija
T
Defronzo
Ralph A
RA
Groop
Leif
L
D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000235:genetics; D008297:Male; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood / Q000235:genetics
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol