title: First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates.
abstract: Divinyl sulfone-modified carbohydrates have been synthesized for the first time by reacting easily available carbohydrate epoxides with thioethanol in a regiospecific fashion. One of the modified divinyl sulfones initiated significant cell death in Entamoeba species and the influence of the anomeric configurations on the biological activities of these sugar-derived divinyl sulfones has been highlighted. The most active compound in this series was found to be devoid of any toxicity.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, India.
authors.forename: Tarun Kumar
authors.initials: TK
authors.lastname: Pal
authors.forename: Tuli
authors.initials: T
authors.lastname: Dey
authors.forename: Arindam
authors.initials: A
authors.lastname: Chakrabarty
authors.forename: Debanjana
authors.initials: D
authors.lastname: Dey
authors.forename: Sudip K
authors.initials: SK
authors.lastname: Ghosh
authors.forename: Tanmaya
authors.initials: T
authors.lastname: Pathak
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004747:Entamoeba / Q000187:drug effects*; D004852:Epoxy Compounds; D006801:Humans; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D002241:Carbohydrates; D004852:Epoxy Compounds; D013450:Sulfones; C009873:divinyl sulfone