title: [An experimental research of neuroglobin expression changes and neural apoptosis after traumatic brain injury].
abstract: OBJECTIVE
  To study the expression changes of neuroglobin in rats with the model of diffuse traumatic brain injury and explore the relationship between the neuroglobin and neuron apoptosis in traumatic brain injury.
  
  
  METHODS
  The diffuse traumatic brain injury of rats was induced by the Marmarou's 'weight-drop' device. And the immunohistochemical technique was used to detect the expression changes of neuroglobin and neuron apoptosis in rat brain at different time points post-injury.
  
  
  RESULTS
  The expression of neuroglobin increased twice and reached peaks at 2 hours and 72 hours post-injury respectively. And the increased expression of neuroglobin from 30 minutes to 1 hour post-injury and from 48 hours to 72 hours post-injury accompanied with the decreased expression ratio of Bax to Bcl-2.
  
  
  CONCLUSIONS
  The increased expression of neuroglobin in traumatic brain injury informed us that neuroglobin had anti-apoptosis action in post-injury neuron. It could protect the neuron from traumatic stress and secondary ischemia and hypoxia insults during ultra-early and acute stages.
authors.affiliation: Surgical Department 2, South Building, PLA General Hospital, Beijing 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Ya-zhuo
authors.initials: YZ
authors.lastname: Hu
authors.forename: Zhi-tao
authors.initials: ZT
authors.lastname: Han
authors.forename: Hong-hong
authors.initials: HH
authors.lastname: Zhang
authors.forename: Ai-jia
authors.initials: AJ
authors.lastname: Shang
authors.forename: De-wei
authors.initials: DW
authors.lastname: Gao
authors.forename: Ding-biao
authors.initials: DB
authors.lastname: Zhou
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology*; D005914:Globins / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000078787:Neuroglobin; D009474:Neurons / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D005914:Globins