Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.
Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.
Chepenik
Lara G
LG
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. lara.chepenik@yale.edu
Raffo
Mariella
M
Hampson
Michelle
M
Lacadie
Cheryl
C
Wang
Fei
F
Jones
Monique M
MM
Pittman
Brian
B
Skudlarski
Pawel
P
Blumberg
Hilary P
HP
D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000098:blood supply / Q000503:physiopathology*; D001714:Bipolar Disorder / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply / Q000503:physiopathology*; D012146:Rest / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen