Is the updated Schwartz formula appropriate for assessing renal function prior to hematopoietic stem cell transplantation?
Assessing renal function is an integral part of evaluating pediatric patients for hematopoietic stem cell transplantation (HSCT). The most accurate method is DTPA-Tc-(99m) GFR testing. However, it is costly and time consuming. The Schwartz formula, which was recently updated, represents an inexpensive and readily available alternative. We assessed agreement between the original and updated formula and DTPA-Tc-(99m) in 107 patients who were being evaluated for HSCT. Agreement between both formulas and DTPA-Tc-(99m) was poor, although the updated formula performed marginally better. The Schwartz formulas do not appear to be accurate enough to be used for pre-transplant kidney function evaluation.
Qayed
Muna
M
Aflac Cancer Center and Blood Disorders Service, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, USA. muna.qayed@choa.org
Thompson
Audra
A
Applegate
Kristy
K
Haight
Ann
A
Rogatko
Andre
A
Chiang
Kuang-Yueh
KY
Horan
John
J
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D055815:Young Adult
D003404:Creatinine