title: Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy.
abstract: After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4(+) T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.
authors.affiliation: Clinical Infectious Diseases, Tor Vergata University, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Sarmati
authors.forename: S G
authors.initials: SG
authors.lastname: Parisi
authors.forename: C
authors.initials: C
authors.lastname: Andreoni
authors.forename: E
authors.initials: E
authors.lastname: Nicastri
authors.forename: A R
authors.initials: AR
authors.lastname: Buonomini
authors.forename: C
authors.initials: C
authors.lastname: Boldrin
authors.forename: L
authors.initials: L
authors.lastname: Dori
authors.forename: M
authors.initials: M
authors.lastname: Montano
authors.forename: C
authors.initials: C
authors.lastname: Tommasi
authors.forename: S
authors.initials: S
authors.lastname: Andreis
authors.forename: V
authors.initials: V
authors.lastname: Vullo
authors.forename: G
authors.initials: G
authors.lastname: Palù
authors.forename: M
authors.initials: M
authors.lastname: Andreoni
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D006678:HIV / Q000145:classification / Q000472:pathogenicity*; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D056189:Viral Tropism
chemical_list: D019380:Anti-HIV Agents