title: COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.
abstract: The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
authors.affiliation: Duke University Medical Center, Division of Medical Genetics, Department of Pediatrics, Durham, North Carolina 27710, USA. vandana.shashi@duke.edu
authors.forename: Vandana
authors.initials: V
authors.lastname: Shashi
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Howard
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: Jessica
authors.initials: J
authors.lastname: Kaczorowski
authors.forename: Margaret N
authors.initials: MN
authors.lastname: Berry
authors.forename: Kelly
authors.initials: K
authors.lastname: Schoch
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Spence
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kwapil
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D003072:Cognition Disorders / Q000235:genetics*; D004062:DiGeorge Syndrome / Q000235:genetics*; D056344:Executive Function / Q000502:physiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D014633:Valine / Q000235:genetics
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine