title: Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.
abstract: Three new dihydro-beta-agarofuran polyesters, 1alpha,9beta-difuranoyloxy-2-oxodihydro-beta-agarofuran (1), 1alpha,9beta-difuranoyloxy-2-oxo-3-enedihydro-beta-agarofuran (2), and 1alpha,9beta-difuranoyloxydihydro-beta-agarofuran (3), have been isolated from the CHCl(3) extract of the root bark of Osyris lanceolata, together with two known pentacylic triterpenoids, 4 and 5. Compounds 1-5 did not scavenge the DPPH radical within 30 min of reaction time. All five compounds displayed antifungal activity against Candida albicans. Compounds 1, 3, 4, and 5 showed antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa, with 4 and 5 being the most active. Compound 2 displayed weak antibacterial activity only against Escherichia coli.
authors.affiliation: Department of Chemistry, University of Botswana, P/Bag 0022, Gaborone, Botswana.
authors.forename: Elizabeth M O
authors.initials: EM
authors.lastname: Yeboah
authors.forename: Runner R T
authors.initials: RR
authors.lastname: Majinda
authors.forename: Anders
authors.initials: A
authors.lastname: Kadziola
authors.forename: Alfred
authors.initials: A
authors.lastname: Muller
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000494:pharmacology; D001902:Botswana; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D029630:Santalaceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D010851:Picrates; D012717:Sesquiterpenes; D014315:Triterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl