[Study on different proportion formulas of activating blood circulation by FTIR].
Fourier transform spectroscopy (FTIR) and two-dimensional correlation spectroscopy were used to analyze different compatibility forms of sargentgloryvine stem, radix paeoniae rubra and cortex moutan in order to study the FTIR spectra of different proportion formulas. The results indicate that different proportion formulas have distinct change regularity in FTIR spectra, second derivative spectra and synchronous 2D. Key components of sargentgloryvine stem's characteristic absorption band are 1 610, 1 518 and 1 446 cm(-1) which are characteristic absorption band of aromatic material, and in the original formula, that shows stronger peak than others, suggesting that original formula can make the best of composition of drug action. In the different proportion formulas, 1 614 cm(-1) is nearer to 1 610 cm(-1), which is sargentgloryvine stem's characteristic absorption band, than to 1 706 cm(-1), illustrating that sargentgloryvine stem is more influential formula than others. According to identification and ascription of characteristic absorption band, it was initially revealed that different proportion of drug dosage can affect pharmacodynamic action of integral formula.
Xu
Mao-Ling
ML
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. baby.mao.mao@hotmail.com
Li
Hui-Fen
HF
Zhou
Qun
Q
Yin
Quan
Q
Sun
Su-Qin
SQ
Wu
Xian-Zhong
XZ
D001775:Blood Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D029596:Paeonia; D018547:Plant Stems; D017550:Spectroscopy, Fourier Transform Infrared
D004365:Drugs, Chinese Herbal; C038881:moutan cortex