title: Liquid antisolvent preparation of amorphous cefuroxime axetil nanoparticles in a tube-in-tube microchannel reactor.
abstract: This article presents the preparation of nanoparticles of amorphous cefuroxime axetil (CFA) in a microporous tube-in-tube microchannel reactor (MTMCR). The experimental results indicated that CFA particle with a tunable size of 400-1400 nm could be achieved under a high throughput in the range of 1.5-6L/min. The average particle size decreased with increasing overall volumetric flow rate and decreasing CFA concentration, micropore size, and annular channel width. The produced CFA nanoparticles were characterized by SEM, XRD, FT-IR, DSC and a dissolution test, which indicated that the nanosized CFA was amorphous and exhibited higher dissolution rate compared to the raw CFA. The MTMCR might offer a general and facile pathway for mass production of the nanoparticles of hydrophobic pharmaceuticals thanks to its high throughput capacity and excellent micromixing performance.
authors.affiliation: Key Laboratory for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Wen-Zhen
authors.initials: WZ
authors.lastname: Zhu
authors.forename: Jie-Xin
authors.initials: JX
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Shao
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Qian-xia
authors.initials: QX
authors.lastname: Zhang
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D004867:Equipment Design; D004987:Ethers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D009038:Motion; D053758:Nanoparticles; D010316:Particle Size; D033362:Powder Diffraction; D012212:Rheology; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D004987:Ethers; C011779:diisopropyl ether; D002444:Cefuroxime; C040738:cefuroxime axetil