Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.
A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.
Kharel
Madan Kumar
MK
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.
Pahari
Pallab
P
Lian
Hui
H
Rohr
Jürgen
J
D000105:Acetyl Coenzyme A / Q000737:chemistry; D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008316:Malonyl Coenzyme A / Q000737:chemistry; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*; D013302:Streptomyces / Q000737:chemistry; D000095602:Angucyclines and Angucyclinones
D000105:Acetyl Coenzyme A; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D008316:Malonyl Coenzyme A; D048630:Polyketide Synthases; C003289:rabelomycin; D000095602:Angucyclines and Angucyclinones