Immunosuppressive sesquiterpenes from Buddleja daviddi.
Six new sesquiterpenes, 2,6(12),10-humulatrien-7β-ol-1-one (1), 2 α-acetoxy-5α-methoxy-enantio-caryophylla-8(15)-en-3-one (2), 2α-acetoxy-5α-hydroxy-enantio-caryophylla-8(15)-en-3-one (3), 2α-acetoxy-4β,5α-hydroxy-enantio-caryophylla-8(15)-en-3-one ( 4), 2α-acetoxy-4β,5β-hydroxy-enantio-caryophylla-8(15)-en-3-one (5), 2β-acetoxy-4-caryophyllen-8β-ol-3-one (6), and nineteen known compounds were isolated from the ethanol extract of Buddleja daviddi. The structures were elucidated by spectroscopic methods. Compounds 8-11, 14, 16, 17, and 20 showed significant immunosuppressive activities, and 8-11 and 14 were cytotoxic on HeLa and L929 cell lines.
Zhang
Wen
W
School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yao
Zhi
Z
Zhang
Yan Wen
YW
Zhang
Xing Xiang
XX
Takaishi
Yoshihisa
Y
Duan
Hong Quan
HQ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D032861:Buddleja / Q000737:chemistry*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D027343:Rhizome; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D012717:Sesquiterpenes