title: The influence of tube voltage and phantom size in computed tomography on the dose-response relationship of dicentrics in human blood samples.
abstract: The aim of this study was to investigate the dose response relationship of dicentrics in human lymphocytes after CT scans at tube voltages of 80 and 140 kV. Blood samples from a healthy donor placed in tissue equivalent abdomen phantoms of standard, pediatric and adipose sizes were exposed at dose levels up to 0.1 Gy using a 64-slice CT scanner. It was found that both the tube voltage and the phantom size significantly influenced the CT scan-induced linear dose-response relationship of dicentrics in human lymphocytes. Using the same phantom (standard abdomen), 80 kV CT x-rays were biologically more effective than 140 kV CT x-rays. However, it could also be determined that the applied phantom size had much more influence on the biological effectiveness. Obviously, the increasing slopes of the CT scan-induced dose response relationships of dicentrics in human lymphocytes obtained in a pediatric, a standard and an adipose abdomen have been induced by scattering effects of photons, which strongly increase with increasing phantom size.
authors.affiliation: TRG Diagnostic Imaging, Bayer Schering Pharma AG, Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Jost
authors.forename: P
authors.initials: P
authors.lastname: Lengsfeld
authors.forename: M
authors.initials: M
authors.lastname: Voth
authors.forename: E
authors.initials: E
authors.lastname: Schmid
authors.forename: H
authors.initials: H
authors.lastname: Pietsch
mesh_terms: D001769:Blood / Q000378:metabolism*; D002138:Calibration; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects / Q000648:ultrastructure; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D019047:Phantoms, Imaging; D017785:Photons; D011874:Radiometry / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water