Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains.
Metallic and superparamagnetic DNA-templated nanoparticle (NP) chains are examined as potential imaging agents. Proton relaxation times (T(1) and T(2)) are measured for DNA nanostructures using nuclear magnetic resonance (NMR) spectroscopy. The layer-by-layer (LBL) method was used to encapsulate the DNA-templated NP chains and demonstrated a change in proton relaxation times. Results from this study suggest that LBL-coated, DNA-templated nanostructures can serve as effective imaging agents for magnetic resonance imaging (MRI) applications.
Jaganathan
Hamsa
H
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47906, USA.
Gieseck
Richard L
RL
Ivanisevic
Albena
A
D003035:Cobalt / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D007089:Image Enhancement; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011522:Protons
D003287:Contrast Media; D005290:Ferric Compounds; D011522:Protons; C000499:ferric oxide; D003035:Cobalt; D006046:Gold; D004247:DNA