title: Simultaneous automatic control of oxygen and carbon dioxide blood gases during cardiopulmonary bypass.
abstract: In this work an automatic control strategy is presented for the simultaneous control of oxygen and carbon dioxide blood gas partial pressures to be used during cardiopulmonary bypass surgery with heart-lung machine support. As the exchange of blood gases in the artificial extracorporeal lung is a highly nonlinear process comprising varying time delays, uncertainties, and time-varying parameters, it is currently being controlled manually by specially trained perfusionist staff. The new control strategy includes a feedback linearization routine with augmented time-delay compensation and two external linear gain-scheduled controllers, for partial oxygen and carbon dioxide pressures. The controllers were robustly tuned and tested in simulations with a detailed artificial lung (oxygenator) model in cardiopulmonary bypass conditions. Furthermore, the controllers were implemented in an ex vivo experiment using fresh porcine blood as a substitute fluid and a special deoxygenation technique to simulate a patient undergoing cardiopulmonary bypass. Both controllers showed robust stability during the experiments and a good disturbance rejection to extracorporeal blood flow changes. This automatic control strategy is proposed to improve patient's safety by fast control reference tracking and good disturbance rejection under varying conditions.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Ruhr University, Bochum, Germany. berno.misgeld@rub.de
authors.forename: Berno J E
authors.initials: BJ
authors.lastname: Misgeld
authors.forename: Jürgen
authors.initials: J
authors.lastname: Werner
authors.forename: Martin
authors.initials: M
authors.lastname: Hexamer
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D004867:Equipment Design; D006355:Heart-Lung Machine; D010100:Oxygen / Q000097:blood*; D013552:Swine
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen