title: Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.
abstract: A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.
authors.affiliation: Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China. tangpc@shhrp.com
authors.forename: Tang Peng
authors.initials: TP
authors.lastname: Cho
authors.forename: Lin Zhi
authors.initials: LZ
authors.lastname: Gang
authors.forename: Yang Fang
authors.initials: YF
authors.lastname: Long
authors.forename: Wang
authors.initials: W
authors.lastname: Yang
authors.forename: Wang
authors.initials: W
authors.lastname: Qian
authors.forename: Zhang
authors.initials: Z
authors.lastname: Lei
authors.forename: Luo Jing
authors.initials: LJ
authors.lastname: Jing
authors.forename: Feng
authors.initials: F
authors.lastname: Ying
authors.forename: Yan Pang
authors.initials: YP
authors.lastname: Ke
authors.forename: Leng
authors.initials: L
authors.lastname: Ying
authors.forename: Feng
authors.initials: F
authors.lastname: Jun
mesh_terms: D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D051379:Mice; D008815:Mice, Inbred Strains; D009795:Octanes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D001643:Bridged Bicyclo Compounds; D054873:Dipeptidyl-Peptidase IV Inhibitors; D009795:Octanes