title: [Pharmacoeconomy in acne--evaluation of benefit and economics].
abstract: BACKGROUND
  Acne belongs to the most common skin diseases and has a prevalence in the adolescence of nearly 100% and in adults of about 4%. The quality of life indes is significantly reduced und has impact on daily activities and social life and physical and psychological well being as well. The socioeconomic relevance is based not only on its prevalence but on direct and indirect costs. For acne therapy the knowledge on therapeutic costs is of importance but the cost benefit ratio as well.
  
  
  OBJECTIVE
  Evidence of therapeutic costs in acne and economic benefit of the therapy.
  
  
  METHODS
  Systematic review of Cochrane data.
  
  
  RESULTS
  Calculations reveal general costs of acne treatment in Germany over 400 Mill.Euro per year. For the treatment with topical retinoids, BPO and antibiotics as well as systemic drugs only a few studies on costeffectiveness are available. For topical treatments results are not conclusive and dependent on the different health systems. New topical combinations may have a better economic outcome, however, more studies are needed. With regard to systemic therapies of moderate to severe acne based on the international references the costbenefit ratio favours the treatment with oral isotretinoin on the longterm outcome. Superiority is based on the relationship of costs and clinical outcome and the increased quality of life as well (cost-benefit ratio). It has to be emphazised that only longterm observations over years will lead to a valid calculation of costs and benefit. FACIT: Taking the high social and quality of life impact into consideration an early, well targeted and effective therapy is prevailing. Initial higher cost are balanced by a high quality of outcome under experienced dermatological supervision. The patients benefit is ranked over the final costs because of its medical, social and ethical aspects. To sample more differentiated data on pharmacoeconomic aspects well designed new clinical studies are to be set up.
authors.affiliation: Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Dermatologie und Venerologie, Hamburg Competenzzentrum Versorgungsforschung in der Dermatologie CVderm. m.radtke@uke.uni-hamburg.de
authors.forename: Marc A
authors.initials: MA
authors.lastname: Radtke
authors.forename: Ines
authors.initials: I
authors.lastname: Schäfer
authors.forename: Matthias
authors.initials: M
authors.lastname: Augustin
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology / Q000523:psychology; D000293:Adolescent; D000328:Adult; D002648:Child; D003362:Cost-Benefit Analysis; D003430:Cross-Sectional Studies; D016527:Drug Costs / Q000706:statistics & numerical data*; D005858:Germany; D006801:Humans; D009313:National Health Programs / Q000191:economics*; D011788:Quality of Life / Q000523:psychology; D055815:Young Adult