On-line monitoring of a microwave-assisted chemical reaction by nanolitre NMR-spectroscopy.
We report the use of a nanolitre nuclear magnetic resonance (NMR) spectroscopy microfluidic chip hyphenated to a continuous-flow microlitre-microwave irradiation set-up, for on-line monitoring and rapid optimization of reaction conditions.
Gomez
M Victoria
MV
Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.
Verputten
Hein H J
HH
Díaz-Ortíz
Angel
A
Moreno
Andres
A
de la Hoz
Antonio
A
Velders
Aldrik H
AH
D009682:Magnetic Resonance Spectroscopy; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008872:Microwaves; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
D009930:Organic Chemicals