[Invitation to the immunoglobulin world].
One of the most basic characteristics of the organism is to recognize self and non-self. Immune system is a typical system that fulfills this characteristic, and the immunoglobulins play important roles in it. The immunoglobulins circulating in internal or secreting to external space of the body, are basically characterized as a soluble form of cell surface receptors. The immunoglobulin has two kinds of domains. One is the variable domain that binds the antigen and the other is the constant domain that has the effecter functions. The immunoglobulin molecule can be obviously identified in vertebrates. In mammals, five immunoglobulin classes, IgG, IgA, IgM, IgD and IgE are classified. It is important to recognize that our immune system assign immunological roles among classes especially between IgG and IgA after class switch from IgM. IgG, the major immunoglobulin in plasma or extra vascular spaces, has the most versatile function of immunoglobulin molecules; such as placenta transfer, complement fixation and cell binding. On the other hand, IgA, the major immunoglobulin in secretions, does not show any complement fixation unless denatured. These facts implicate an aggressive characteristic of IgG in systemic immune response inside of the body, and a defensive characteristic of IgA in mucosal immune response on the surface of the body. Further, they allot the immunological roles to fetus or baby, in other words, IgG transferred from placenta protects fetus and newborn, and then IgA secreted in milk protects baby from mucosal invasion of pathogenic organisms.
Mafune
Naoki
N
Laboratory of Medical Dietetics, Rakuno Gakuen University, Ebetsu 069-8501, Japan. mafune@rakuno.ac.jp
D000818:Animals; D001536:Bence Jones Protein; D019143:Evolution, Molecular; D006801:Humans; D007107:Immune System / Q000276:immunology; D007136:Immunoglobulins / Q000737:chemistry / Q000145:classification / Q000276:immunology; D007938:Leukemia / Q000209:etiology; D009101:Multiple Myeloma / Q000209:etiology; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface
D007136:Immunoglobulins; D011956:Receptors, Cell Surface; D001536:Bence Jones Protein