title: Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system.
abstract: To apply the Osteoarthritis Research Society International (OARSI) assessment system to an osteoarthritis model, 44 Wistar rats were randomized into treadmill-running exercise or control group. At 6, 8, and 10 weeks, medial knee joints were histopathologically evaluated, and aggrecan neoepitope and TUNEL staining were performed. Cartilage changes in exercise group were histopathologically and histochemically compatible with early OA. Total modified Mankin system (MMS) scores were significantly higher at all time points (each P ≤ 0.01) in exercise than in control group. However, only tibial OARSI scores of runners were higher at 10 weeks (P < 0.05), although OARSI scores were found to be significantly correlated with MMS scores. Both total MMS (Spearman's coefficient ρ = 0.786) and OARSI scores (ρ = 0.443 for femoral; ρ = 0.604 for tibial) were significantly associated with the exercise duration. In conclusion, the OARSI system may not be sensitive to early OA changes induced by treadmill exercise.
authors.affiliation: Department of Internal Medicine, Clinical Research Institute, Seoul National University College of Medicine, 28 Yongun-dong, Chongno-gu, Seoul 110-744, Korea.
authors.forename: Yun Jong
authors.initials: YJ
authors.lastname: Lee
authors.forename: Ji Ah
authors.initials: JA
authors.lastname: Park
authors.forename: Sei Hoon
authors.initials: SH
authors.lastname: Yang
authors.forename: Kwang Yong
authors.initials: KY
authors.lastname: Kim
authors.forename: Byoung Kwon
authors.initials: BK
authors.lastname: Kim
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Lee
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Jeong-Wook
authors.initials: JW
authors.lastname: Seo
authors.forename: Frank
authors.initials: F
authors.lastname: Echtermeyer
authors.forename: Thomas
authors.initials: T
authors.lastname: Pap
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
mesh_terms: D053674:Aggrecans / Q000032:analysis; D000818:Animals; D002356:Cartilage / Q000473:pathology; D005080:Exercise Test / Q000009:adverse effects*; D020287:In Situ Nick-End Labeling; D008297:Male; D020370:Osteoarthritis, Knee / Q000209:etiology* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013977:Tibia / Q000473:pathology
chemical_list: D053674:Aggrecans