(1)H NMR Study of the solution structure of sarafotoxin-S6b.
Sarafotoxin-S6b has been synthesized and studied by (1)H NMR in 50 50 acetonitrile/water mixture. All spin systems were identified and assigned with the aid of 2D experiments. On the basis of these data, a 3D structure of sarafotoxin is proposed and compared to that of [Nle(7)]endothelin obtained in the same conditions. From this study, it appeared that sarafotoxin-S6b and [Nle(7)]endothelin roughly share the same 3D structure, the main differences being located in the 4-7 loop bearing the sequence variation.
Aumelas
A
A
Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France.
Chiche
L
L
Mahe
E
E
Le-Nguyen
D
D
Sizun
P
P
Berthault
P
P
Perly
B
B