IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure.
We identify possible differences in the cytokine/chemokine profiles in cerebrospinal fluid (CSF) from children with encephalopathy and febrile seizure. Interleukin (IL)-1beta, 2, 4, 5, 6, 7, 8, 10, 12, 13, 17, interferon-gamma, tumour necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta were measured simultaneously in CSF supernatants from children with encephalopathy (n = 8), febrile seizure (n = 16) and fever without neurological complications (n = 8). IL-8 in CSF from children with encephalopathy was significantly elevated compared to that in CSF from children with febrile seizure and fever without neurological complications. IL-8 in CSF was also higher than serum IL-8, suggesting that increased IL-8 was generated from glia cells or astrocytes, not by leakage from serum. Increased IL-8 in CSF in encephalopathy may protect against severe brain damage.
Asano
T
T
Department of Pediatrics, Nippon Medical School, Chiba-Hokusoh Hospital, Chiba-Pre., Japan. VFF13540@nifty.ne.jp
Ichiki
K
K
Koizumi
S
S
Kaizu
K
K
Hatori
T
T
Fujino
O
O
Mashiko
K
K
Sakamoto
Y
Y
Miyasho
T
T
Fukunaga
Y
Y
D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid / Q000276:immunology; D054407:Chemokine CCL4 / Q000134:cerebrospinal fluid / Q000276:immunology; D002675:Child, Preschool; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000276:immunology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000134:cerebrospinal fluid / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000134:cerebrospinal fluid / Q000276:immunology; D006801:Humans; D007118:Immunoassay; D007223:Infant; D007371:Interferon-gamma / Q000134:cerebrospinal fluid / Q000276:immunology; D007378:Interleukins / Q000134:cerebrospinal fluid* / Q000276:immunology; D008297:Male; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid* / Q000276:immunology*; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000276:immunology
C066507:CCL4 protein, human; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D016179:Granulocyte Colony-Stimulating Factor; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor