[(3)H]ketanserin binding increases in monkey cortex following basal forebrain lesions with ibotenic acid.
The present study investigated the effects of damage to the basal forebrain cholinergic system upon [(3)H]ketanserin binding in the neocortex and hippocampus of monkeys. [(3)H]Ketanserin specifically binds to serotonin type-2 receptor sites. Lesions were placed in the medial septal area, nucleus basalis, or both regions. Ten months later, [(3)H]ketanserin binding was increased in the neocortex, but not in the hippocampus, while levels of choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, EC 2.3.1.6) activity decreased in the neocortex and hippocampus. Changes in the levels of choline acetyltransferase and [(3)H]ketanserin binding were correlated significantly in the neocortex (r = ?0.64, P < 0.025), but not in the hippocampus. The data suggest that degeneration of the basal forebrain cholinergic system may alter serotonergic function in the neocortex.
Wenk
G L
GL
Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, U.S.A.
Engisch
K L
KL
McCall
L D
LD
Mitchell
S J
SJ
Aigner
T G
TG
Struble
R L
RL
Price
D L
DL
Olton
D S
DS