Estimated prevalence of sickle cell in northern Haiti.
OBJECTIVE
The purpose of this study is to estimate the prevalence of sickle hemoglobin in northern Haiti.


METHODS
Sickle cell testing occurred from 2002-2009. Blood samples from 1035 subjects were collected for diagnostic purposes, de-identified, and made available for the study.


METHODS
Bethesda Medical Center and Eben-Ezer Clinic in northern Haiti.


METHODS
Study subjects included prenatal patients, their companions, clinic staff and volunteers. All subjects were Haitian and selected to most closely represent healthy patients present at the clinic. Deidentification of the blood samples precluded the need for informed consent.


METHODS
Each subject was tested for sickle hemoglobin using a standard hemoglobin solubility test and results were recorded as either positive or negative.


RESULTS
The estimated prevalence of sickle hemoglobin was 15.1% with a 95% confidence interval of 12.2-18%.


CONCLUSIONS
These prevalence rates validate the clinical significance of sickle cell disorder, help guide clinical decisions, and suggest the need to develop intervention programs among the people of northern Haiti.
Randolph
Tim R
TR
Department of Clinical Laboratory Science, Doisy College of Health Sciences, Saint Louis University, St. Louis, MO 63104-1111, USA. randoltr@slu.edu
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006205:Haiti / Q000453:epidemiology; D006451:Hemoglobin, Sickle / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D011247:Pregnancy; D015995:Prevalence; D015203:Reproducibility of Results
D006451:Hemoglobin, Sickle; D006454:Hemoglobins