[Radiation induced modification of human somatic cells chromosome sensitivity in testing mutagenic effect of bleomycin].
The voluntary investigation of hidden chromosome instability in 53 persons with different intensity of radiation exposure had been carried pout using modified "G2-bleomycin sensitivity assay". In all examined groups the individual levels of chromosome injuries under identical bleomycin exposure varied in wide range and didnrt depend on their initial values in the intact cultures. Among control donors and individuals with low radiation exposure approximately 33% hypersensitive persons had been identified that can be considered as genetically caused phenomenon. In patients recovered from acute radiation syndrome (57.9%) persons expressed hidden chromosome instability. The data permit to assume that high doses of ionizing radiation can modify inherited human chromosomes susceptibility to mutagen exposure.
Pilins'ka
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MA
Dybs'kyĭ
S S
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Dybs'ka
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Pedan
L R
LR
D000293:Adolescent; D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000633:toxicity*; D047852:Chernobyl Nuclear Accident; D043171:Chromosomal Instability / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011832:Radiation Injuries / Q000097:blood / Q000235:genetics*; D055815:Young Adult
D009153:Mutagens; D001761:Bleomycin