Antihypertensive efficacy of Melothria maderaspatana leaf extract on sham-operated and uninephrectomized DOCA-salt hypertensive rats.
The plant Melothria maderaspatana (MME) has been used traditionally as antihypertensive and has been proven scientifically to possess high antioxidant and hepatoprotective activity. The present study has been designed to investigate the antihypertensive effect of ethanolic extract of MME leaves on sham-operated and uninephrectomized DOCA-salt-induced hypertensive male albino Wistar rats. A midscapular incision was made on each rat and the left kidney was excised after ligation of the renal artery. The surgical wound was closed using a suture. After one week recovery period, hypertension was induced by subcutaneous injection of DOCA-salt solution, twice a week, and the rats received a 1% sodium chloride solution as drinking water throughout the experimental period. After 6 weeks injection of DOCA-salt, systolic, diastolic and mean arterial blood pressure was significantly elevated as compared with sham-operated control. Treatment with MME significantly decreased theblood pressure. Thus, the results show that MME possesses antihypertensive activity in DOCA-salt hypertensive rats.
Veeramani
Chinnadurai
C
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
Aristatle
Balakrishnan
B
Pushpavalli
Ganesan
G
Pugalendi
Kodukkur Viswanathan
KV
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006332:Cardiomegaly / Q000473:pathology / Q000517:prevention & control; D019662:Cucurbitaceae / Q000737:chemistry*; D003900:Desoxycorticosterone; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007674:Kidney Diseases / Q000473:pathology / Q000517:prevention & control; D008297:Male; D009392:Nephrectomy; D009543:Nifedipine / Q000627:therapeutic use; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D010936:Plant Extracts; D003900:Desoxycorticosterone; D009543:Nifedipine