[Study on processing principle of Aconitum pendulum].
OBJECTIVE
To study the processing principles of different processed products of Aconitum pendulum.


METHODS
Using high performance liquid chromatography and acute toxicity test to compare the changes in chemical composition and toxicity of the roots and processed products of A. pendulum.


RESULTS
The main toxic components of the roots of A. pendulum were aconitine, deoxyaconitine and 3-acetylaconitine. The contents of these three alkaloids were significantly reduced in processed products, while benzoylaconitine significantly increased. In addition, processed products emerged aconine, polyschistine-D, beyzoyldeoxyaconine, 16-epi-pyroaconitine and 16-epi-pyrodeoxyaconitine. From the structural analysis, these new emerged compounds transformed from the aconitine, deoxyaconitine and 3-acetylaconitine.


CONCLUSIONS
Different processing methods can reduce the toxicity of the roots of A. pendulum. Processing principle is ester hydrolysis and high-temperature pyrolysis.
Wang
Yujie
Y
Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. superwangyj@126.com
Zhang
Jing
J
Tian
Huiping
H
Zeng
Chenjuan
C
Yao
Zhe
Z
Zhang
Yi
Y
D000157:Aconitine / Q000031:analogs & derivatives / Q000032:analysis; D031841:Aconitum / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice
C057219:deoxyaconitine; C031321:3-acetylaconitine; D000157:Aconitine