title: Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.
abstract: With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, PR China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Zhou
authors.forename: Huifeng
authors.initials: H
authors.lastname: Wu
authors.forename: Chunyang
authors.initials: C
authors.lastname: Liao
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Diao
authors.forename: Jiping
authors.initials: J
authors.lastname: Zhen
authors.forename: Linlin
authors.initials: L
authors.lastname: Chen
authors.forename: Qinzhao
authors.initials: Q
authors.lastname: Xue
mesh_terms: D000818:Animals; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D009930:Organic Chemicals / Q000032:analysis / Q000633:toxicity*; D021381:Protein Transport; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism*; D014116:Toxicology / Q000379:methods*; D015027:Zebrafish / Q000378:metabolism
chemical_list: D004785:Environmental Pollutants; D009930:Organic Chemicals; D018336:Receptors, Aryl Hydrocarbon