Direct ruthenium-catalyzed C-C coupling of ethanol: diene hydro-hydroxyethylation to form all-carbon quaternary centers.
Under ruthenium-catalyzed transfer hydrogenation conditions, direct C-C coupling of ethanol and 2-substituted dienes occurs to furnish products of hydro-hydroxyethylation: anti-configured neopentyl homoallylic alcohols. Identical adducts are generated from acetaldehyde under related conditions employing isopropanol as reductant.
Han
Hoon
H
Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA.
Krische
Michael J
MJ
D000466:Alkadienes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D000431:Ethanol / Q000138:chemical synthesis / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000466:Alkadienes; D000431:Ethanol; D012428:Ruthenium