Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and "click" linker.
A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.
Sharma
Pallavi
P
School of Chemistry, University of Nottingham, Nottingham, NG7 2RD.
Moses
John E
JE