Enantioselective organocatalytic addition of azlactones to maleimides: a highly stereocontrolled entry to 2,2-disubstituted-2H-oxazol-5-ones.
The first highly diastereo- and enantioselective organocatalytic synthesis of 2,2-disubstituted-2H-oxazol-5-ones is described. The addition of oxazolones to maleimides is promoted by bifunctional thiourea catalysts, which afford the corresponding 2,2-disubstituted-2H-oxazol-5-ones with total regio- and stereocontrol.
Alba
Andrea-Nekane R
AN
Department of Organic Chemistry, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain.
Valero
Guillem
G
Calbet
Teresa
T
Font-Bardía
Mercé
M
Moyano
Albert
A
Rios
Ramon
R