First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates.
Divinyl sulfone-modified carbohydrates have been synthesized for the first time by reacting easily available carbohydrate epoxides with thioethanol in a regiospecific fashion. One of the modified divinyl sulfones initiated significant cell death in Entamoeba species and the influence of the anomeric configurations on the biological activities of these sugar-derived divinyl sulfones has been highlighted. The most active compound in this series was found to be devoid of any toxicity.
Pal
Tarun Kumar
TK
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, India.
Dey
Tuli
T
Chakrabarty
Arindam
A
Dey
Debanjana
D
Ghosh
Sudip K
SK
Pathak
Tanmaya
T
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004747:Entamoeba / Q000187:drug effects*; D004852:Epoxy Compounds; D006801:Humans; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D000981:Antiprotozoal Agents; D002241:Carbohydrates; D004852:Epoxy Compounds; D013450:Sulfones; C009873:divinyl sulfone