New and classic families of secreted fungal heme peroxidases.
Heme-containing peroxidases secreted by fungi are a fascinating group of biocatalysts with various ecological and biotechnological implications. For example, they are involved in the biodegradation of lignocelluloses and lignins and participate in the bioconversion of other diverse recalcitrant compounds as well as in the natural turnover of humic substances and organohalogens. The current review focuses on the most recently discovered and novel types of heme-dependent peroxidases, aromatic peroxygenases (APOs), and dye-decolorizing peroxidases (DyPs), which catalyze remarkable reactions such as peroxide-driven oxygen transfer and cleavage of anthraquinone derivatives, respectively, and represent own separate peroxidase superfamilies. Furthermore, several aspects of the "classic" fungal heme-containing peroxidases, i.e., lignin, manganese, and versatile peroxidases (LiP, MnP, and VP), phenol-oxidizing peroxidases as well as chloroperoxidase (CPO), are discussed against the background of recent scientific developments.
Hofrichter
Martin
M
Department of Environmental Biotechnology, International Graduate School of Zittau, Markt 23, 02763, Zittau, Germany. hofrichter@ihi-zittau.de
Ullrich
René
R
Pecyna
Marek J
MJ
Liers
Christiane
C
Lundell
Taina
T
D000595:Amino Acid Sequence; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry / Q000145:classification / Q000201:enzymology* / Q000235:genetics; D006418:Heme / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010544:Peroxidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D021381:Protein Transport; D016415:Sequence Alignment
D005656:Fungal Proteins; D006418:Heme; D010544:Peroxidases