title: Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of beta-TCP ceramics.
abstract: The objective of this study was to evaluate the influence of MgO and SrO doping on the mechanical and biological properties of beta-tricalcium phosphate (beta-TCP). beta-TCP was doped with two different binary compositions, 0.25 and 1.0wt.% SrO along with 1.0wt.% MgO. MgO and SrO doping increased the beta phase stability at a sintering temperature of 1250 degrees C and marginally decreased the compressive strength of beta-TCP. An in vitro cell-material interaction study, using human fetal osteoblast cells (hFOB), indicated that doped beta-TCP was non-toxic, and MgO/SrO dopants improved cell attachment and growth. beta-TCP implants doped with 1.0wt.% MgO and 1.0wt.% SrO showed good in vivo biocompatibility when tested in male Sprague-Dawley rats for 16 weeks. Histomorphology analysis indicated that MgO/SrO-doped beta-TCP promoted more osteogenesis than pure beta-TCP. In vivo osteocalcin and type I collagen assay also revealed faster bone formation in rats with doped beta-TCP implant compared to rats with pure beta-TCP implant. Low Ca(2+) concentration in the urine of rats with doped beta-TCP implant confirmed slower degradation of MgO/SrO-doped beta-TCP than pure beta-TCP.
authors.affiliation: Washington State University, Pullman, 99164-2920, USA.
authors.forename: Shashwat S
authors.initials: SS
authors.lastname: Banerjee
authors.forename: Solaiman
authors.initials: S
authors.lastname: Tarafder
authors.forename: Neal M
authors.initials: NM
authors.lastname: Davies
authors.forename: Amit
authors.initials: A
authors.lastname: Bandyopadhyay
authors.forename: Susmita
authors.initials: S
authors.lastname: Bose
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry*; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry*; D019245:Compressive Strength; D005333:Fetus / Q000166:cytology; D006801:Humans; D008277:Magnesium Oxide / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D015675:Osteocalcin / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D013324:Strontium / Q000737:chemistry*
chemical_list: D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D015675:Osteocalcin; D008277:Magnesium Oxide; D013324:Strontium