Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus.
Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.
Kadikoy
Huseyin
H
Department of Medicine, Baylor College of Medicine, Houston, TX, USA. hkadikoy@gmail.com
Paolini
Michael
M
Achkar
Katafan
K
Suki
Wadi
W
Gaber
A Osama
AO
Anwar
Nabeel
N
Jeroudi
Abdallah
A
Barrios
Roberto
R
Abdellatif
Abdul
A
D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006463:Hemolytic-Uremic Syndrome / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000276:immunology; D008875:Middle Aged; D011649:Pulmonary Alveolar Proteinosis / Q000139:chemically induced* / Q000175:diagnosis*; D012008:Recurrence; D020123:Sirolimus / Q000009:adverse effects* / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D020123:Sirolimus; D016559:Tacrolimus