title: In vitro activity of azithromycin against nontyphoidal Salmonella enterica.
abstract: The in vitro activity of azithromycin against 1,237 nontyphoidal Salmonella enterica isolates collected from Finnish patients between 2003 and 2008 was investigated. Only 24 (1.9%) of the isolates tested and 15 (5.1%) of the 294 isolates with reduced fluoroquinolone susceptibility had azithromycin MICs of >or=32 microg/ml. These data show that azithromycin has good in vitro activity against nontyphoidal S. enterica, and thus, it may be a good candidate for clinical treatment studies of salmonellosis.
authors.affiliation: Antimicrobial Resistance Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Marianne
authors.initials: M
authors.lastname: Gunell
authors.forename: Pirkko
authors.initials: P
authors.lastname: Kotilainen
authors.forename: Jari
authors.initials: J
authors.lastname: Jalava
authors.forename: Pentti
authors.initials: P
authors.lastname: Huovinen
authors.forename: Anja
authors.initials: A
authors.lastname: Siitonen
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Hakanen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005387:Finland / Q000453:epidemiology; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D017963:Azithromycin