title: Further evidence supporting the association between 5HTR2C gene and bipolar disorder.
abstract: Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).
authors.affiliation: Department of Psychiatry, Catholic University, Gemelli Hospital, Rome, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Mazza
authors.forename: Laura
authors.initials: L
authors.lastname: Mandelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinotti
authors.forename: Marco
authors.initials: M
authors.lastname: Di Nicola
authors.forename: Daniela
authors.initials: D
authors.lastname: Tavian
authors.forename: Gloria
authors.initials: G
authors.lastname: Negri
authors.forename: Elisa
authors.initials: E
authors.lastname: Colombo
authors.forename: Sara
authors.initials: S
authors.lastname: Missaglia
authors.forename: Diana
authors.initials: D
authors.lastname: De Ronchi
authors.forename: Roberto
authors.initials: R
authors.lastname: Colombo
authors.forename: Luigi
authors.initials: L
authors.lastname: Janiri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult
chemical_list: D044405:Receptor, Serotonin, 5-HT2C