title: Vascular endothelial growth factor genetic polymorphisms and haplotypes in women with migraine.
abstract: Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154)A, and G(-634)C) and VEGF haplotypes are associated with migraine. We studied 114 healthy women without migraine and 175 women with migraine (129 without aura, and 46 with aura). We found no differences in the distributions of VEGF genotypes and alleles (p > 0.05). However, the CAC haplotype was more frequent in controls than in migraine patients, and the AGC haplotype was more frequent in patients with migraine with aura than in controls (both p < 0.05). These findings suggest that VEGF haplotypes affect susceptibility to migraine.
authors.affiliation: Department of Pharmacology, State University of Campinas, Sao Paulo, Brazil.
authors.forename: Flavia M
authors.initials: FM
authors.lastname: Gonçalves
authors.forename: Alisson
authors.initials: A
authors.lastname: Martins-Oliveira
authors.forename: Jose G
authors.initials: JG
authors.lastname: Speciali
authors.forename: Tatiane C
authors.initials: TC
authors.lastname: Izidoro-Toledo
authors.forename: Marcelo R
authors.initials: MR
authors.lastname: Luizon
authors.forename: Fabiola
authors.initials: F
authors.lastname: Dach
authors.forename: Jose E
authors.initials: JE
authors.lastname: Tanus-Santos
mesh_terms: D000483:Alleles; D005260:Female; D015316:Genetic Therapy; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008881:Migraine Disorders / Q000235:genetics; D011110:Polymorphism, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D042442:Vascular Endothelial Growth Factors / Q000235:genetics
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors