Genetics of complex disorders.
The success stories of identifying genes in Mendelian disorders have stimulated research that aims at identifying the genetic determinants in complex disorders, in which both genetics, environment and chance affect the pathogenetic processes. This review summarizes the brief history and lessons learned from genetic analysis of complex disorders and outlines some landscapes ahead for medical research.
Kere
Juha
J
Department of Biosciences and Nutrition, Karolinska Institutet, 14157 Huddinge, Sweden. juha.kere@ki.se
D002877:Chromosomes, Human / Q000235:genetics; D003001:Cloning, Molecular; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000266:history*; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000266:history*; D005826:Genetics, Medical / Q000266:history*; D055106:Genome-Wide Association Study; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
D005819:Genetic Markers