[Role of matrix metalloproteinase in transformation of subdural effusion into chronic subdural hematoma].
OBJECTIVE
To investigate the role of matrix metalloproteinase (MMP) in the transformation of subdural effusion into chronic subdural hematoma.


METHODS
The clinical data of 8 patients with subdural effusion that transformed into chronic subdural hematoma were collected and MMP-2 and MMP-9 levels were detected in the sudural effusion, chronic subdural hematoma and capsules of hematoma using gelatin-zymography.


RESULTS
MMP-2 and MMP-9 increased significantly in chronic subdural hematoma as compared with those in subdural effusion (P<0.01), and their levels were also significantly higher in the outer membrane than in the inner membrane of hematoma.


CONCLUSIONS
Subdural effusion is a risk factor for the occurrence of chronic subdural hematoma, in which process MMP plays a role as the promoting factor acting primarily in the outer membrane of the hematoma.
Wang
Zhi-fei
ZF
Department of Neurosurgery, Third Xiangya Hospital, Central South University, Changsha 410013, China. doctorwangzhifei@163.com
Liao
Da-guang
DG
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006408:Hematoma, Subdural / Q000201:enzymology* / Q000209:etiology*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D013353:Subdural Effusion / Q000150:complications* / Q000201:enzymology
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9