title: Antimycotic effectiveness against dermatophytes: comparison of two in vitro tests.
abstract: Seven antimycotic drugs (econazole, enilconazole, fluconazole, griseofulvin, itraconazole, ketoconazole, and miconazole) were tested against 36 dermatophyte strains (19 M. canis, 7 T. mentagrophytes, 5 M. gypseum, 2 M. cookei, 1 T. rubrum, 1 T. ajelloi, and 1 T. terrestre) isolated from animals, humans, and the environment. Two in vitro methods were compared: a micro-dilution test based on the CLSI M38-A method, and a disk-diffusion test. Fluconazole was not effective in vitro against the dermatophytes. Econazole and enilconazole were the most effective. Thirteen strains were griseofulvin-resistant. The correlation between the two methods was statistically significant for enilconazole, griseofulvin, itraconazole, and miconazole.
authors.affiliation: Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Alma Mater Studiorum-Università di Bologna, Bologna, Italy. roberta.galuppi@unibo.it
authors.forename: Roberta
authors.initials: R
authors.lastname: Galuppi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gambarara
authors.forename: Cristina
authors.initials: C
authors.lastname: Bonoli
authors.forename: Fabio
authors.initials: F
authors.lastname: Ostanello
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Tampieri
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods*
chemical_list: D000935:Antifungal Agents