title: Solution conformation of endothelin-3 by (1)H NMR and distance geometry calculations.
abstract: Endothelin-3 dissolved in 10% aqueous acetic acid was studied by nuclear magnetic resonance spectroscopy. A total of 363 distances (143 intra-residue, 108 sequential and 112 long range) was compiled from the nuclear Overhauser effect spectra and used in distance geometry calculations. The molecule assumes a compact conformation stabilized by hydrophobic interactions of the side chains. There is a helix-like structure between the residues 9-15 and an extended strand at the N-terminus. The C-terminus is in close proximity to the bicyclic ring.
authors.affiliation: Merrell Dow Research Institute, 16, rue d'Ankara, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Bortmann
authors.forename: J
authors.initials: J
authors.lastname: Hoflack
authors.forename: J T
authors.initials: JT
authors.lastname: Pelton
authors.forename: V
authors.initials: V
authors.lastname: Saudek