title: Genome-wide association mapping for female fertility traits in Danish and Swedish Holstein cattle.
abstract: A genome-wide association study was conducted using a mixed model analysis for QTL for fertility traits in Danish and Swedish Holstein cattle. The analysis incorporated 2,531 progeny tested bulls, and a total of 36,387 SNP markers on 29 bovine autosomes were used. Eleven fertility traits were analyzed for SNP association. Furthermore, mixed model analysis was used for association analyses where a polygenic effect was fitted as a random effect, and genotypes at single SNPs were successively included as a fixed effect in the model. The Bonferroni correction for multiple testing was applied to adjust the significance threshold. Seventy-four SNP-trait combinations showed chromosome-wide significance, and five of these were significant genome-wide. Twenty-four QTL regions on 14 chromosomes were detected. Strong evidence for the presence of QTL that affect fertility traits were observed on chromosomes 3, 5, 10, 13, 19, 20, and 24. The QTL intervals were generally smaller than those described in earlier linkage studies. The identification of fertility trait-associated SNPs and mapping of the corresponding QTL in small chromosomal regions reported here will facilitate searches for candidate genes and candidate polymorphisms.
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Research Centre Foulum, Aarhus University, Tjele, Denmark. goutam.sahana@agrsci.dk
authors.forename: G
authors.initials: G
authors.lastname: Sahana
authors.forename: B
authors.initials: B
authors.lastname: Guldbrandtsen
authors.forename: C
authors.initials: C
authors.lastname: Bendixen
authors.forename: M S
authors.initials: MS
authors.lastname: Lund
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary*; D003718:Denmark; D005260:Female; D005298:Fertility / Q000235:genetics*; D016678:Genome; D055106:Genome-Wide Association Study / Q000662:veterinary*; D005838:Genotype; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D013548:Sweden