[Effects of CRF receptor antagonist on rem sleep in neonatal rat].
OBJECTIVE
To observe the role of NB127914, a CRF R1 receptor antagonist, in the regulation of neonatal sleep/wake cycle.


METHODS
Rat pups were surgically implanted with electrodes at postnatal day(PN) 13. At PN 14, 6 hours polysomnographic recording data were continuously collected before and after administration of various doses of NBI 27914, atropine and the same amount of saline.


RESULTS
Compared with baseline, rapid eye movement (REM) sleep was significantly reduced and was replaced primarily by non-REM (NREM) sleep in all groups treated with NBI, but not with dimethyl sulfoxide/saline. Atropine suppressed REM sleep significantly and increased wakefulness simultaneously.


CONCLUSIONS
Blockage of corticotropin-releasing factor (CRF) R1 receptors deprives neonatal rat REM sleep.
Liu
Xue-dong
XD
Department of Physiology, Medical School in Zhengzhou University, Zhengzhou 450052, China.
Fan
Hong-kun
HK
Zhang
Gui-hong
GH
Wang
Shu-chun
SC
Zhang
Zhao
Z
Feng
Ping-fu
PF
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D017286:Polysomnography; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology; D000099052:CRF Receptor, Type 1
C471210:2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; D000814:Aniline Compounds; D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1