Nanomedicine strategies for molecular targets with MRI and optical imaging.
The science of 'theranostics' plays a crucial role in personalized medicine, which represents the future of patient management. Over the last decade an increasing research effort has focused on the development of nanoparticle-based molecular-imaging and drug-delivery approaches, emerging as a multidisciplinary field that shows promise in understanding the components, processes, dynamics and therapies of a disease at a molecular level. The potential of nanometer-sized agents for early detection, diagnosis and personalized treatment of diseases is extraordinary. They have found applications in almost all clinically relevant biomedical imaging modality. In this review, a number of these approaches will be presented with a particular emphasis on MRI and optical imaging-based techniques. We have discussed both established molecular-imaging approaches and recently developed innovative strategies, highlighting the seminal studies and a number of successful examples of theranostic nanomedicine, especially in the areas of cardiovascular and cancer therapy.
Pan
Dipanjan
D
Caruthers
Shelton D
SD
Chen
Junjie
J
Winter
Patrick M
PM
SenPan
Angana
A
Schmieder
Anne H
AH
Wickline
Samuel A
SA
Lanza
Gregory M
GM
D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods* / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D015394:Molecular Structure; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D057285:Precision Medicine; D045663:Quantum Dots
D005290:Ferric Compounds; C000499:ferric oxide