title: Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.
abstract: 5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO products in relation to tumorigenesis have been described. Thus, insight regarding the biochemistry of 5LO is relevant for better understanding of normal physiology, and for development of therapy.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, 17177 Stockholm, Sweden. olof.radmark@ki.se
authors.forename: Olof
authors.initials: O
authors.lastname: Rådmark
authors.forename: Bengt
authors.initials: B
authors.lastname: Samuelsson
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D020134:Catalytic Domain; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D015289:Leukotrienes / Q000096:biosynthesis*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology; D010766:Phosphorylation; D011487:Protein Conformation
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D002352:Carrier Proteins; D015289:Leukotrienes; D008565:Membrane Proteins; D001094:Arachidonate 5-Lipoxygenase; D002118:Calcium