Neonatal enucleation alters catecholamine and serotonin metabolism in the lateral geniculate and visual cortex in developing rats.
Levels of dopamine, noradrenaline and serotonin and of their metabolites along with tryptophan hydroxylase, tyrosine hydroxylase and monoamine oxidase A and B activities have been determined in lateral geniculate (LG) and visual cortex (VC) after enucleation during postnatal development. Lateral geniculate showed more changes in serotonin metabolism than visual cortex, whereas the most significant change in visual cortex was in noradrenaline metabolism. Both monoamines underwent a general decrease at day 15. An increase of the MAO-B to MAO-A ratio during postnatal development was found.
Vizuete
M L
ML
Departamento de Bioquímica, Bromatología y Toxicología, Universidad de Sevilla, Spain.
Santiago
M
M
Herrera
A J
AJ
Machado
A
A
Cano
J
J