title: Wavelet-based estimation of the hemodynamic responses in diffuse optical imaging.
abstract: Diffuse optical imaging uses light to provide a surrogate measure of neuronal activation through the hemodynamic responses. The relative low absorption of near-infrared light enables measurements of hemoglobin changes at depths reaching the first centimeter of the cortex. The rapid rate of acquisition and the access to both oxy and deoxy-hemoglobin leads to new challenges when trying to uncouple physiology from the signal of interest. In particular, recent work provided evidence of the presence of a 1/f noise structure in optical signals and showed that a general linear model based on wavelets can be used to decorrelate the structured noise and provide a superior estimator of response amplitude when compared with conventional techniques. In this work the wavelet techniques are extended to recover the full temporal shape of the hemodynamic responses. A comparison with other models is provided as well as a case study on finger-tapping data.
authors.affiliation: Ecole de Technologie Supérieure, Département de Génie Electrique, 1100 rue Notre-Dame ouest, Montréal, Québec, Canada H3C 1K3. jmlina@ele.etsmtl.ca
authors.forename: J M
authors.initials: JM
authors.lastname: Lina
authors.forename: C
authors.initials: C
authors.lastname: Matteau-Pelletier
authors.forename: M
authors.initials: M
authors.lastname: Dehaes
authors.forename: M
authors.initials: M
authors.lastname: Desjardins
authors.forename: F
authors.initials: F
authors.lastname: Lesage
mesh_terms: D000465:Algorithms; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D010101:Oxygen Consumption / Q000502:physiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods*; D058067:Wavelet Analysis