title: [Clinicopathological aspects of and survival in patients with clinical stage I bronchioloalveolar carcinoma].
abstract: OBJECTIVE
  To analyze the clinicopathological aspects of bronchioloalveolar carcinoma (BAC) and the survival in a sample of patients at clinical stage I.
  
  
  METHODS
  A retrospective study involving 26 patients diagnosed with clinical stage I BAC and undergoing surgery at the Thoracic Diseases Institute of the Federal University of Rio de Janeiro, in the city of Rio de Janeiro, Brazil, between 1987 and 2007. We analyzed clinicopathological and radiological aspects, as well as mortality and survival. The data, which were collected from the medical charts of the patients, were statistically analyzed.
  
  
  RESULTS
  Females predominated (n = 16). The mean age at diagnosis was 68.5 years. Most patients were active smokers (69.2%). The most common forms of presentation of BAC were the asymptomatic form (84.6%) and the nodular form (88.5%). Involvement of the upper lobes predominated (57.7%). Stage IB was the most common pathological stage, followed by stages IA and IIB (46.2%, 38.4% and 15.4%, respectively). There was no in-hospital mortality. Four patients died during the postoperative follow-up, with a mean disease-free survival time of 21.3 months. The overall five-year survival rate was 83%. The probability of survival for the patients diagnosed after 1999 showed a trend toward an increase when compared with that for those diagnosed up through 1999 (three-year survival rate: 92% vs. 68%; p = 0.07).
  
  
  CONCLUSIONS
  The clinicopathological aspects of this study sample were similar to those of patients with BAC evaluated in previous studies.
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. sammartinodb@terra.com.br
authors.forename: Daniel Sammartino
authors.initials: DS
authors.lastname: Brandão
authors.forename: Rui
authors.initials: R
authors.lastname: Haddad
authors.forename: Giovanni Antonio
authors.initials: GA
authors.lastname: Marsico
authors.forename: Carlos Henrique Ribeiro
authors.initials: CH
authors.lastname: Boasquevisque
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000401:mortality* / Q000473:pathology*; D000368:Aged; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology