title: Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones.
abstract: Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones and diaryl phosphine oxides has been developed for the first time employing multifunctional organocatalysts. Optically active products bearing quaternary chiral carbon stereocenters were obtained in high yields with good to excellent enantioselectivities (up to 98% ee).
authors.affiliation: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Shigang
authors.initials: S
authors.lastname: Wen
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Haibo
authors.initials: H
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D007659:Ketones / Q000737:chemistry*; D008968:Molecular Conformation; D010087:Oxides / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D010087:Oxides; D010720:Phosphines; C044646:phosphine