title: A case of langerhans cell histiocytosis with anal fistula.
abstract: Langerhans cell histiocytosis (LCH) is an uncommon clinically heterogeneous disorder characterized by the proliferation and accumulation of Langerhans cells with local infiltration of tissues and organ destruction. LCH takes many clinical forms, affecting different systems and different sites in the same system with variable outcomes. Bone, skin, lymph node, pituitary, liver, lung, bone marrow and spleen involvement can be seen in patients with LCH. Involvement of the perianal site is rare. In this article, a 16-month-old boy with multiple organ involvement including skin, liver, lung, and bone is presented. Aside from these systemic involvements, he also had a simple anal fistula. According to our best knowledge, this case of LCH with anal fistula is only the second to be reported in childhood. We would like to emphasize that LCH may be associated with anal fistula; therefore, we suggest that patients with LCH should be examined for this condition.
authors.affiliation: Department of Pediatric Hematology, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Akbayram
authors.forename: Cihangir
authors.initials: C
authors.lastname: Akgun
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozen
authors.forename: Avni
authors.initials: A
authors.lastname: Kaya
authors.forename: Oguz
authors.initials: O
authors.lastname: Tuncer
authors.forename: Sevil Ari
authors.initials: SA
authors.lastname: Yuca
authors.forename: Huseyin
authors.initials: H
authors.lastname: Caksen
authors.forename: Ahmet Faik
authors.initials: AF
authors.lastname: Oner
mesh_terms: D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D012003:Rectal Fistula / Q000209:etiology*