Aging men and lipids.
Many theories aim at explaining the mechanisms of aging and death in humans. Decreased levels of androgens, growth hormone, and insulin-like growth factor accompany natural aging in men. Androgens influence the growth and maturation of men in various stages of their life. The action of androgens is performed by binding or not binding to androgen receptors. However, various actions of androgens were clarified after the discovery and genotyping of the androgen receptor. The influence of androgens on the lipid profile was reported by several researchers. This negative influence of androgens in men and the positive influence of estrogens in women are responsible for the higher impact of atherogenesis in men compared with women. In aging men, this negative influence of androgens on the lipid profile is more pronounced. This review considers the influence of age on lipid metabolism in men.
Kolovou
Genovefa
G
Onassis Cardiac Surgery Center, Athens, Greece.
Bilianou
Helen
H
Marvaki
Apostolia
A
Mikhailidis
Dimitri P
DP
D000367:Age Factors; D000375:Aging / Q000097:blood*; D047649:Andropause; D001823:Body Composition; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D004967:Estrogens; D005838:Genotype; D006304:Health Status; D006801:Humans; D008019:Life Style; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D011944:Receptors, Androgen / Q000097:blood / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D014481:United States / Q000453:epidemiology
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004967:Estrogens; D008055:Lipids; D011944:Receptors, Androgen; D013739:Testosterone