title: Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems.
abstract: Cellulose acetate (CA) fibers loaded with the ester prodrugs of naproxen, including methyl ester, ethyl ester and isopropyl ester, were prepared through electrospinning using acetone/N,N-dimethylacetamide(DMAc)/ethanol (4:1:1, v/v/v) as solvent. The chemical and morphological characterizations of the medicated fibers were investigated by means of SEM, DSC, XRD and FTIR, as well as the studies of the drug release properties. The results indicated that the morphology and diameter of the fibers were influenced by the concentration of spinning solution, applied voltage, electrospun solvent and the surfactants. The average diameters of the fibers ranged between 100 and 500 nm for three prodrugs. There was good compatibility between CA and three prodrugs in the blended fibers, respectively. In vitro release indicated that constant drug release from the fiber was observed over 6 days. The prodrugs were successfully encapsulated into the fibers, and this system was stable in terms of effectiveness in release.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People's Republic of China.
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Wu
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Branford-White
authors.forename: Li-min
authors.initials: LM
authors.lastname: Zhu
authors.forename: Nichoals P
authors.initials: NP
authors.lastname: Chatterton
authors.forename: Deng-guang
authors.initials: DG
authors.lastname: Yu
mesh_terms: D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004952:Esters / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D055616:Microtechnology / Q000379:methods; D008954:Models, Biological; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D017550:Spectroscopy, Fourier Transform Infrared; D057968:Transdermal Patch
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004952:Esters; D011108:Polymers; D011355:Prodrugs; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C005062:acetylcellulose; D009288:Naproxen; D002482:Cellulose