title: A multipronged approach to the identification and study of an important oncogene in GBM.
abstract: In this issue of Cancer Cell, Zheng et al. provide strong evidence that PLAGL2 serves as an oncogene in GBM. They demonstrate that PLAGL2 inhibits differentiation and promotes a persistent, self-renewing state, at least in part because of activation of Wnt signaling.
authors.affiliation: Intellectual and Developmental Disabilities Research Center and Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. harley@ucla.edu
authors.forename: Harley I
authors.initials: HI
authors.lastname: Kornblum