On a possible mechanism of abnormal brain development in experimental hyperphenylalaninemia.
It has been observed that high levels of phenylalanine inhibit the synthesis of sulfatides in brain. A possible scenario leading to a decreased number of synaptic contacts in the adult is developed as an explanation for brain dysfunction. The evidence for each of the steps of this scenario is reviewed.
Hommes
F A
FA
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, GA 30912-3331, U.S.A.
Matsuo
K
K