ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data.
BACKGROUND
Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especially, small insertions and deletions.


RESULTS
Here we describe ParMap, a statistical algorithm for the identification of complex genetic variants, such as small insertion and deletions, using partially mapped reads in nextgen sequencing data.


CONCLUSIONS
We report ParMap's successful application to the mutation analysis of chromosome X exome-captured leukemia DNA samples.
Khiabanian
Hossein
H
Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, NY, USA. hossein@c2b2.columbia.edu.
Van Vlierberghe
Pieter
P
Palomero
Teresa
T
Ferrando
Adolfo A
AA
Rabadan
Raul
R