Facile one-pot synthesis of three different substituted thiazoles from propargylic alcohols.
Three different substituted thiazoles have been successfully synthesized from readily available propargylic alcohols. Various secondary propargylic alcohols or tertiary propargylic alcohols participated well in the reaction, providing the desired products in good yields. This method provides a flexible and rapid route to substituted thiazoles.
Gao
Xun
X
Department of Chemistry, College of Chemistry and Chemical Engineering, and State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, Fujian, P. R. China.
Pan
Ying-ming
YM
Lin
Min
M
Chen
Li
L
Zhan
Zhuang-ping
ZP
D000480:Alkynes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D020005:Propanols / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*
D000480:Alkynes; D020005:Propanols; D013844:Thiazoles; C028255:propargyl alcohol