Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis.
OBJECTIVE
To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.


METHODS
We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model.


RESULTS
We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), -881 (A/G, 3 studies), -826 (C/T, 3 studies), and -297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, -881, -297 with autoimmune and inflammatory diseases. An association of NFKBIA gene -826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97-3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07-4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78-6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78-10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22-3.36, P = 0.006).


CONCLUSIONS
This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene -826C/T polymorphism, but not with 2758A/G, -881A/G, and -279C/T.
Zhang
Guo-Long
GL
Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023 Jiangsu, China.
Zou
Yan-Feng
YF
Feng
Xiao-Liang
XL
Shi
He-Jian
HJ
Du
Xu-Feng
XF
Shao
Min-Hua
MH
Gu
Yong
Y
Zhou
Qing
Q
D001327:Autoimmune Diseases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics*; D007249:Inflammation / Q000235:genetics*; D000072000:NF-KappaB Inhibitor alpha; D011110:Polymorphism, Genetic; D039781:PubMed
D020672:I-kappa B Proteins; C000606204:NFKBIA protein, human; D000072000:NF-KappaB Inhibitor alpha