title: Synthesis of 3,3'-diaryl-substituted 2,2'-diamino-1,1'-binaphthyl and its derivatives.
abstract: Substitution at the 3 and/or 3' position of a binaphthyl skeleton sometimes enhances stereoselectivity during asymmetric reactions. High-yield and stepwise introduction of aryl groups into the 2,2'-diamino derivative has been established for the first time via an ortho-lithiation/iodization/Suzuki-Miyaura coupling protocol. The results described herein will facilitate the synthesis of a variety of 3,3'-substituted 2,2'-diamino-1,1'-binaphthyl compounds, which are key intermediates for obtaining valuable related ligands and organocatalysts.
authors.affiliation: Contribution from the Research Center for Materials Science and the Department of Chemistry, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Muraoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakatsuka
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang
authors.forename: Masato
authors.initials: M
authors.lastname: Kitamura