The effect of 6-weeks of aerobic exercise training on serum fetuin-A levels in non-diabetic obese women.
Emerging evidence suggests that fetuin-A, a liver-derived glycoprotein, represents an important factor in the pathophysiology of the metabolic syndrome, type 2 diabetes and cardiovascular disease. So far circulating fetuin-A was found to be increased in fatty liver disease, however, the precise mechanisms regulating fetuin-A expression and secretion are largely unknown. Here we assessed serum fetuin-A levels in 14 non-diabetic, obese women (BMI 36.5 ± 1.5 kg/m (2)) before and after a 6-week aerobic exercise program. Despite decreasing waist circumference (from 114.9 ± 3.5 to 112.3 ± 3.2 cm; P = 0.006) and body fat content (from 44.1 ± 1.5% to 43.4 ± 1.5%; P = 0.022) regular exercise 3-times per week over a 6-week period did not affect serum fetuin-A levels (before vs. after: 0.440 ± 0.018 vs. 0.440 ± 0.014 μg/ml; P = 0.767). Thus, our data provide evidence against a major role of exercise in the regulation of serum fetuin-A levels in non-diabetic obese women.
Schultes
B
B
Interdisciplinary Obesity Center, Kantonsspital St Gallen, Rorschach, Switzerland. bernd.schultes@kssg.ch
Frick
J
J
Ernst
B
B
Stefan
N
N
Fritsche
A
A
D050154:Adiposity; D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D015992:Body Mass Index; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000628:therapy*; D017697:Premenopause; D055105:Waist Circumference; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein