Electrospun mats from styrene/maleic anhydride copolymers: modification with amines and assessment of antimicrobial activity.
New antimicrobial microfibrous electrospun mats from styrene/maleic anhydride copolymers were prepared. Two approaches were applied: (i) grafting of poly(propylene glycol) monoamine (Jeffamine® M-600) on the mats followed by formation of complex with iodine; (ii) modification of the mats with amines of 8-hydroxyquinoline or biguanide type with antimicrobial activity. Microbiological screening against S. aureus, E. coli and C. albicans revealed that both the formation of complex with iodine and the covalent attachment of 5-amino-8-hydroxyquinoline or of chlorhexidine impart high antimicrobial activity to the mats. In addition, S. aureus bacteria did not adhere to modified mats.
Ignatova
Milena
M
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Bl. 103A, 1113 Sofia, Bulgaria.
Stoilova
Olya
O
Manolova
Nevena
N
Markova
Nadya
N
Rashkov
Iliya
I
D000588:Amines / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008299:Maleic Anhydrides / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D020058:Styrene / Q000737:chemistry*
D000588:Amines; D000890:Anti-Infective Agents; D008299:Maleic Anhydrides; D011108:Polymers; D020058:Styrene