title: Genetic characterization of wild-type measles viruses isolated in China, 2006-2007.
abstract: Molecular characterization of wild-type measles viruses in China during 1995-2004 demonstrated that genotype H1 was endemic and widely distributed throughout the country. H1-associated cases and outbreaks caused a resurgence of measles beginning in 2005. A total of 210,094 measles cases and 101 deaths were reported by National Notifiable Diseases Reporting System (NNDRS) and Chinese Measles Laboratory Network (LabNet) from 2006 to 2007, and the incidences of measles were 6.8/100,000 population and 7.2/100,000 population in 2006 and 2007, respectively. Five hundred and sixty-five wild-type measles viruses were isolated from 24 of 31 provinces in mainland China during 2006 and 2007, and all of the wild type virus isolates belonged to cluster 1 of genotype H1. These results indicated that H1-cluster 1 viruses were the predominant viruses circulating in China from 2006 to 2007. This study contributes to previous efforts to generate critical baseline data about circulating wild-type measles viruses in China that will allow molecular epidemiologic studies to help measure the progress made toward China's goal of measles elimination by 2012.
authors.affiliation: WHO WPRO Regional Reference Measles Lab and State Key Laboratory for Molecular Virology & Genetic Engineering, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Ji
authors.forename: Songtao
authors.initials: S
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.forename: Naiying
authors.initials: N
authors.lastname: Mao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Peishan
authors.initials: P
authors.lastname: Lu
authors.forename: Changyin
authors.initials: C
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.forename: Huanying
authors.initials: H
authors.lastname: Zheng
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Defang
authors.initials: D
authors.lastname: Dai
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhou
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Zhenying
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shengwei
authors.initials: S
authors.lastname: Wu
authors.forename: Lijuan
authors.initials: L
authors.lastname: Nan
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liang
authors.forename: David Alexander
authors.initials: DA
authors.lastname: Featherstone
authors.forename: Paul A
authors.initials: PA
authors.lastname: Rota
authors.forename: William J
authors.initials: WJ
authors.lastname: Bellini
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D005838:Genotype; D008457:Measles / Q000453:epidemiology / Q000821:virology*; D008459:Measles virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D010802:Phylogeny