Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart.
Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (DeltaPsi(m)) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of DeltaPsi(m) within the intact heart during ischemia-reperfusion injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate DeltaPsi(m) spatiotemporal properties and arrhythmia propensity.
Jin
Hongwei
H
Cardiovascular Research Center, Division of Cardiology, Mount Sinai School of Medicine, New York, New York, USA.
Nass
Robert D
RD
Joudrey
Paul J
PJ
Lyon
Alexander R
AR
Chemaly
Elie R
ER
Rapti
Kleopatra
K
Akar
Fadi G
FG
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D006332:Cardiomegaly / Q000503:physiopathology*; D004195:Disease Models, Animal; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000502:physiology*; D008929:Mitochondria, Heart; D032383:Myocytes, Cardiac / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015427:Reperfusion Injury / Q000503:physiopathology
D017382:Reactive Oxygen Species