Mechanisms of leukocyte trafficking in allergic diseases: insights into new therapies targeting chemokines and chemokine receptors.
Marked inflammatory infiltration by activated leukocytes is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identify targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.
Toda
Masako
M
Paul-Ehrlich-Institut, Junior Research Group 'Experimental Allergology', Paul-Ehrlich St. 59, Langen 63225, Germany. todma@pei.de
Nakamura
Takao
T
Ohbayashi
Masaharu
M
Ikeda
Yoshifumi
Y
Dawson
Maria
M
Aye
Cho Cho
CC
Miyazaki
Dai
D
Ono
Santa Jeremy
SJ