title: Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by 'click' chemistry.
abstract: Thirteen new 1,2,3-triazoles (5a-e, 15a-d, 17a-b, 19, and 21) were synthesized by 'click' reaction of sugar-derived azides with commercially available acetylenes. The synthesized triazoles were tested in vitro for their biological activity, and compound 5b displayed both antibacterial and antifungal activities at an MIC value of 12.5 microg/mL, while compounds 15b and 19 showed antibacterial activity at an MIC value of 25 microg/mL.
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: L
authors.initials: L
authors.lastname: Vijaya Raghava Reddy
authors.forename: P
authors.initials: P
authors.lastname: Venkat Reddy
authors.forename: Nripendra N
authors.initials: NN
authors.lastname: Mishra
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Shukla
authors.forename: Garima
authors.initials: G
authors.lastname: Yadav
authors.forename: Ranjana
authors.initials: R
authors.lastname: Srivastava
authors.forename: Arun K
authors.initials: AK
authors.lastname: Shaw
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D014230:Triazoles; C018674:tetrahydrofuran