NB-LRR proteins: pairs, pieces, perception, partners, and pathways.
In plants, many of the innate immune receptors or disease resistance (R) proteins contain a NB-LRR (Nucleotide-binding site, Leucine-rich repeat) structure. The recent findings regarding NB-LRR signaling are summarized in this article. An emerging theme is that two NB-LRRs can function together to mediate disease resistance against pathogen isolates. Also, recent results delineate the NB-LRR protein fragments that are sufficient to initiate defense signaling. Importantly, distinct fragments of different NB-LRRs are sufficient for function. Finally, we describe the new roles of accessory proteins and downstream host genes in NB-LRR signaling.
Eitas
Timothy K
TK
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Dangl
Jeffery L
JL
D000818:Animals; D001665:Binding Sites; D006801:Humans; D009711:Nucleotides / Q000378:metabolism*; D010935:Plant Diseases / Q000276:immunology; D010940:Plant Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D020449:Repetitive Sequences, Amino Acid; D015398:Signal Transduction
D009711:Nucleotides; D010940:Plant Proteins