Size selective recognition of small esters by a negative allosteric hemicarcerand.
A bis(resorcinarene) substituted 2,2'-bipyridine was found to bind weakly to small esters like ethyl acetate whereas more bulky esters were not recognized by this hemicarcerand. This size selective molecular recognition could be controlled by a negative cooperative allosteric effect: coordination of a triscarbonyl rhenium chloride fragment to the bipyridine causes a conformational rearrangement that orientates the resorcinarene moieties in different directions so that they cannot act cooperatively in the binding of the substrate.
Staats
Holger
H
University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.
Lützen
Arne
A