Increasing use of disease modifying drugs for MS in Canada.
OBJECTIVE
The course of multiple sclerosis may be slowed by use of the disease modifying drugs (DMDs): subcutaneous or intramuscular interferon beta-1a, interferon beta-1b, glatiramer acetate, and natalizumab. We set out to compare utilization of these drugs in the Canadian provinces from 2002-2007.


METHODS
Using a retrospective cohort analysis, we reviewed population data from International Medical Statistics (IMS) Health between November 2001 and October 2007.


RESULTS
The total annual number of DMD prescriptions increased from 3.9, in 2002, to 5.1, in 2007, per 1,000 Canadians. The total annual cost of prescriptions rose from $187 million to $287 million. Of the four provinces responsible for the majority of prescriptions--Alberta, BC, Ontario, and Quebec--Quebec had the highest average annual prescription rate (7 per 1,000 population) and BC had the lowest rate (3.3 per 1,000 population). Subcutaneous interferon beta-1a was the most commonly used drug whereas glatiramer acetate showed the greatest growth in use from 2002 to 2007.


CONCLUSIONS
Disease modifying drugs prescription rates and costs increased by more than 30% between 2002 and 2007. There was wide variation in DMD prescription rates and relative drug preferences across the provinces.
Rotstein
Dalia L
DL
Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Mamdani
Muhammad
M
O'Connor
Paul W
PW
D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D018450:Disease Progression; D016527:Drug Costs / Q000706:statistics & numerical data / Q000639:trends; D004363:Drug Utilization / Q000191:economics / Q000706:statistics & numerical data*; D017723:Drug Utilization Review / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000191:economics / Q000627:therapeutic use*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000453:epidemiology*; D012189:Retrospective Studies
D007155:Immunologic Factors