title: Vitamin D deficiency in two young adults with biochemical findings resembling pseudohypoparathyroidism type I and type II.
abstract: We report two patients with vitamin D deficiency due to unbalanced diet. The patients initially presented with severe hypocalcemia, normophosphatemia and markedly elevated serum PTH levels. Although nutritional vitamin D deficiency was suspected from their history of gastrointestinal problems and dietary restriction, we conducted Ellsworth- Howard test to exclude the possibility of pseudohypoparathyroidism (PHP). Both patients showed no incremental response of urinary phosphate excretion. However, the urinary cAMP response to exogenous PTH was different between the two. Case 1 showed a blunted response (5-fold and 1.54 micro mol/h increase) and case 2 showed a normal response (39-fold and 3.04 micro mol/h increase). According to the criteria of Ellsworth-Howard test, the data of case 1 was compatible with PHP type I, and of case 2 with PHP type II. The final diagnosis of vitamin D deficiency was established in both patients based on very low serum 25-hydroxyvitamin D levels (less than 5 ng/mL) and the effect of treatment. After calcium supplementation with or without vitamin D, their biochemical abnormalities disappeared. They maintained normocalcemia without medication after correction of their unbalanced diet. The present study indicated that patients with vitamin D deficiency occasionally showed biochemical findings suggestive of PHP and that such patients could exhibit not only PHP type II pattern of response to exogenous PTH but also of type I pattern. Thus our clinical observation suggests the complexity of PTH resistance in vitamin D deficiency and underscores the importance of diet to prevent the disorder.
authors.affiliation: Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Tokyo, Japan. tsekimdphd@endm.twmu.ac.jp
authors.forename: Toshiro
authors.initials: T
authors.lastname: Seki
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hironari
authors.initials: H
authors.lastname: Kimura
authors.forename: Mika
authors.initials: M
authors.lastname: Tsuiki
authors.forename: Masami
authors.initials: M
authors.lastname: Ono
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Miki
authors.forename: Kazue
authors.initials: K
authors.lastname: Takano
authors.forename: Kanji
authors.initials: K
authors.lastname: Sato
mesh_terms: D000328:Adult; D002136:Calcium, Dietary / Q000008:administration & dosage; D002762:Cholecalciferol / Q000008:administration & dosage; D000242:Cyclic AMP / Q000652:urine; D003937:Diagnosis, Differential; D004032:Diet; D005260:Female; D006801:Humans; D006996:Hypocalcemia; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000652:urine; D011547:Pseudohypoparathyroidism; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D; D000242:Cyclic AMP