Hypoxia-inducible factor 1 as one of the "signaling drivers" of Toll-like receptor-dependent and allergic inflammation.
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability. In the last years there has been increasing evidence about the role of this factor in inflammatory/innate immune reactions. It has also been found to contribute to different types of allergic inflammation. In this review the current knowledge about the accumulation and role of HIF-1 in Toll-like receptor-mediated and allergic inflammation is summarized. Differential biochemical mechanisms employed to stabilize the protein in different cases are discussed.
Sumbayev
Vadim V
VV
Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent ME44TB, UK. V.Sumbayev@kent.ac.uk
Nicholas
Sally A
SA
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D051793:Hypoxia-Inducible Factor 1 / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D010100:Oxygen / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D051793:Hypoxia-Inducible Factor 1; D051193:Toll-Like Receptors; D010100:Oxygen