Pterosins from Pteris multifida.
A new C(14) pterosin sesquiterpenoid, named (2R)-pterosin P (1), and a new natural product, named dehydropterosin B (3), were isolated from the aerial parts of Pteris multifida Poir., along with nine known compounds (2, 4-11). By chiral HPLC, compounds 1 and 2 were isolated as a pair of enantiomeric pterosin sesquiterpenoids. The planar structure of 1 was elucidated on the basis of NMR spectroscopy analysis, and the absolute configuration was established by the CD spectrum. In addition, the absolute structure of 1 was further confirmed by single-crystal X-ray diffraction (CuK α). Compounds 3, 5, and 6 showed potent cytotoxicity against PANC-1 (human pancreatic cancer) and NCI-H446 (human small-cell lung cancer) cell lines, with IC(50) values in the range of 4.27-14.63 µM.
Ouyang
Dan-Wei
DW
Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, P R China.
Ni
Xiang
X
Xu
Hai-Yan
HY
Chen
Jia
J
Yang
Pei-Ming
PM
Kong
De-Yun
DY
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D007189:Indans / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D032495:Pteris / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy*
C557811:(2R)-pterosin P; D000972:Antineoplastic Agents, Phytogenic; D007189:Indans; D010936:Plant Extracts; D012717:Sesquiterpenes; C557812:dehydropterosin B