title: Posaconazole salvage treatment in paediatric patients: a multicentre survey.
abstract: While a paediatric dosage has not been defined, posaconazole is occasionally being used in children. We conducted a multicentre retrospective survey and identified 15 patients (median age 10 years [range 3.6-17.5]) who received posaconazole salvage therapy for proven (9 patients) or probable (6 patients) invasive fungal infections. Posaconazole was administered for a median of 32 days (range 4-262) at a median dosage of 21 mg/kg (range 4.8-33.3). None of the patients discontinued therapy due to adverse events, which were mostly mild and observed in 11 patients. Complete or partial responses were observed in 4/7 patients with zygomycosis, 3/4 patients with invasive mould infection, 1/2 patients with invasive aspergillosis and 1/2 patients with chronic disseminated candidiasis. We conclude from the data that posaconazole displays favourable safety and tolerance and may be useful for management of individual paediatric patients with invasive infections.
authors.affiliation: Paediatric Haematology and Oncology, Children's Hospital III, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany. Thomas.Lehrnbecher@kgu.de
authors.forename: T
authors.initials: T
authors.lastname: Lehrnbecher
authors.forename: A
authors.initials: A
authors.lastname: Attarbaschi
authors.forename: M
authors.initials: M
authors.lastname: Duerken
authors.forename: J
authors.initials: J
authors.lastname: Garbino
authors.forename: B
authors.initials: B
authors.lastname: Gruhn
authors.forename: U
authors.initials: U
authors.lastname: Kontny
authors.forename: S
authors.initials: S
authors.lastname: Lüer
authors.forename: R
authors.initials: R
authors.lastname: Phillips
authors.forename: J
authors.initials: J
authors.lastname: Scholz
authors.forename: H J
authors.initials: HJ
authors.lastname: Wagner
authors.forename: T
authors.initials: T
authors.lastname: Wiesel
authors.forename: A H
authors.initials: AH
authors.lastname: Groll
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009181:Mycoses / Q000188:drug therapy*; D016879:Salvage Therapy / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole