title: Malignant somatostatinoma presenting with diabetic ketoacidosis and inhibitory syndrome: pathophysiologic considerations.
abstract: OBJECTIVE
  To describe a patient with diabetic ketoacidosis secondary to a malignant somatostatinoma.
  
  
  METHODS
  We present the clinical, laboratory, radiologic, and pathologic findings of a patient with diabetic ketoacidosis secondary to a malignant somatostatinoma. We also review the potential effects of somatostatin on glucose homeostasis and discuss the underlying pathophysiologic mechanisms.
  
  
  RESULTS
  A 30-year-old woman presented with diabetic ketoacidosis and had a malignant somatostatinoma with hepatic, bone, and lymph node metastasis. She exhibited features of somatostatinoma "inhibitory syndrome" characterized by mild nonketotic hyperglycemia, hypochlorhydria, cholelithiasis, steatorrhea, anemia, and weight loss. In these tumors, the absence of ketoacidosis is thought to arise from the somatostatin-induced simultaneous suppression of the secretion of insulin and glucagon. The patient's primary tumor could not be located.
  
  
  CONCLUSIONS
  Diabetic ketoacidosis may occur in somatostatinomas. The secretion of larger molecular weight forms of somatostatin from the tumor may contribute to the ketogenesis.
authors.affiliation: Department of Endocrinology, Royal Free Hampstead NHS Trust, London, United Kingdom. aikaterini.theodoraki@royalfree.nhs.uk
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Theodoraki
authors.forename: Bernard
authors.initials: B
authors.lastname: Khoo
authors.forename: Arif
authors.initials: A
authors.lastname: Hamda
authors.forename: Frederica
authors.initials: F
authors.lastname: Grillo
authors.forename: Tim
authors.initials: T
authors.lastname: Meyer
authors.forename: Pierre-Marc Gilles
authors.initials: PM
authors.lastname: Bouloux
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001859:Bone Neoplasms / Q000556:secondary; D048909:Diabetes Complications / Q000175:diagnosis; D016883:Diabetic Ketoacidosis / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013005:Somatostatinoma / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013577:Syndrome
chemical_list: D001786:Blood Glucose