title: Cognitive deficits and associated neurological complications in individuals with Down's syndrome.
abstract: Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity. Diagnosis and treatment of neurological complications are important in maintaining optimal cognitive functioning. The cognitive phenotype in Down's syndrome is characterised by impairments in morphosyntax, verbal short-term memory, and explicit long-term memory. However, visuospatial short-term memory, associative learning, and implicit long-term memory functions are preserved. Seizures are associated with cognitive decline and seem to cause additional decline in cognitive functioning, particularly in people with Down's syndrome and comorbid disorders such as autism. Vision and hearing disorders as well as hypothyroidism can negatively impact cognitive functioning in people with Down's syndrome. Dementia that resembles Alzheimer's disease is common in adults with Down's syndrome. Early-onset dementia in adults with Down's syndrome does not seem to be associated with atherosclerotic complications.
authors.affiliation: Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA 92868, USA. itlott@uci.edu
authors.forename: Ira T
authors.initials: IT
authors.lastname: Lott
authors.forename: Mara
authors.initials: M
authors.lastname: Dierssen
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D015897:Comorbidity; D004314:Down Syndrome / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans