[Modern aspects of acne pathogenesis].
BACKGROUND
Acne is worldwide the most common skin disease.


METHODS
Suitable therapeutic regimens of the varying clinical phenotypes require good knowledge of the pathogenesis of the illness.


CONCLUSIONS
Acne vulgaris is an inflammatory disorder at whose emergence androgens, PPAR ligands, regulating neuropeptides and environmental factors are probably involved. These factors interrupt the natural cycling process in the sebaceous gland follicle and support the transition of microcomedones to comedones and inflammatory lesions. Proinflammatory lipids, chemokines and cytokines overtake the role of mediators for the development of acne lesions. Bacterial antigens can potentate the inflammatory phenomena.
Zouboulis
Christos C
CC
Klinik für Dermatologie, Venerologie und Allergologie/Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau-Rosslau. christos.zouboulis@klinikumdessau.de
D000152:Acne Vulgaris / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D000942:Antigens, Bacterial / Q000097:blood; D003430:Cross-Sectional Studies; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D009479:Neuropeptides / Q000097:blood; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics; D011247:Pregnancy; D011425:Propionibacterium acnes / Q000472:pathogenicity; D012307:Risk Factors; D012931:Social Environment; D051193:Toll-Like Receptors / Q000235:genetics; D055815:Young Adult
D000728:Androgens; D000942:Antigens, Bacterial; D018836:Inflammation Mediators; D009479:Neuropeptides; D047492:Peroxisome Proliferator-Activated Receptors; D051193:Toll-Like Receptors