[Study about the clinical and pathological characteristics of salivary duct carcinoma].
OBJECTIVE
To investigate the clinical and pathological characteristics of salivary duct carcinoma (SOC) so as to provide basis for the diagnosis and therapy of SOC.


METHODS
Eight patients suffered with SOC treated in Affiliated Stomatological Hospital of Kunming Medical College from March 2001 to February 2009 were studied retrospectively including the clinical data. Meanwhile, eight tumor specimens were examined for vascular endothelial growth factor (VEGF), cytokeratin (CK), gross cystic disease fluid protein (CC DFP)-15, androgen receptor (AR) and oncogene C-erBb-2 protein expression via immunohistochemistry.


RESULTS
Of the eight patients with SOC, five tumors grew in the parotid gland, the majority of the patients had facial nerve paralysis, three had recurrence. Computerized tomography (CT) showed that no obvious margin and similar crystal. Immunohistochemical staining for the expression of VEGF, CK, GCDFP-15 and C-erbB-2 were carried out in all SOC, while AR in majority.


CONCLUSIONS
SOC is a high-grade malignant carcinoma among all salivary carcinoma, immunohistochemical analysis of SOC has revealed a variety of similarities to ductal carcinoma of the breast. GCDFP-15, AR and C-erBb--2 may play an important role in pathological diagnosis for SOC.
Wang
Wei-hong
WH
Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical College, Kunming 650031, China.
Wang
Chun-yan
CY
Bian
Li
L
Xia
Bin
B
Hu
Yao-yao
YY
Xu
Biao
B
D002277:Carcinoma; D002294:Carcinoma, Squamous Cell; D002352:Carrier Proteins; D006023:Glycoproteins; D006258:Head and Neck Neoplasms; D006801:Humans; D007150:Immunohistochemistry; D026901:Membrane Transport Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011944:Receptors, Androgen; D012189:Retrospective Studies; D018987:Salivary Ducts; D012468:Salivary Gland Neoplasms; D000077195:Squamous Cell Carcinoma of Head and Neck; D042461:Vascular Endothelial Growth Factor A
D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011944:Receptors, Androgen; D042461:Vascular Endothelial Growth Factor A; C410798:AR protein, human; C488892:PIP protein, human