Genetic variation in microRNA networks: the implications for cancer research.
Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.
Ryan
Bríd M
BM
Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068A, Bethesda, MD 20892-4258, USA.
Robles
Ana I
AI
Harris
Curtis C
CC
D017398:Alternative Splicing; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D009369:Neoplasms / Q000737:chemistry / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D035683:MicroRNAs