title: The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia.
abstract: Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.).
authors.affiliation: Department of Cardiology, VU Medical Centre, Amsterdam, the Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: Klein
authors.forename: F C
authors.initials: FC
authors.lastname: Visser