title: Pelvic skeletal metastasis of hepatocellular carcinoma with sarcomatous change: a case report.
abstract: Sarcomatoid hepatocellular carcinoma (HCC) is a very rare histologic variant of HCC. The characteristic of skeletal metastatic sarcomatoid hepatocellular carcinoma has never been reported. We reported a patient with sarcomatoid hepatocellular carcinoma pelvic metastasis who presented with huge pelvic metastasis that had relatively small osteolytic lesion centrally located accompanied by huge bipeduncular invasive expansile lesions into surrounding soft tissue. The lesion showed almost non-isotope uptake in 99mTc-methylene diphosphonate bone scintigraphy study. He underwent radiotherapy and tumor excision but the tumor rapidly recurred. In addition, serum alpha-fetoprotein level was never elevated beyond normal limit (< 20 ng/mL) through the whole course of treatment. We considered sarcomatoid hepatocellular carcinoma bone metastasis a highly aggressive lesion with unusual metastatic pattern. Surgical treatment with adequate safe margin in such a huge tumor with hypervascularity and extensive invasion in the pelvis was difficult; and radiotherapy maybe refractory regarding the sarcomatous nature. Therefore, debulking operation with local symptoms control may provide a better quality of life. And the clinical course suggests sarcomatoid hepatocellular carcinoma is derived from the transition of an ordinary hepatocellular carcinoma.
authors.affiliation: Department of Orthopedic Surgery, National Taiwan University & Hospital, Taipei, Taiwan.
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Yong-Te
authors.initials: YT
authors.lastname: Hsueh
authors.forename: Tsung-Yu
authors.initials: TY
authors.lastname: Lan
authors.forename: Wei-Hsin
authors.initials: WH
authors.lastname: Lin
authors.forename: Karl
authors.initials: K
authors.lastname: Wu
authors.forename: Rong-Sen
authors.initials: RS
authors.lastname: Yang
mesh_terms: D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary* / Q000628:therapy; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000556:secondary* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010384:Pelvic Bones / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000097:blood / Q000556:secondary* / Q000628:therapy; D013997:Time Factors; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome; D051598:Whole Body Imaging; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C097353:AFP protein, human; D000509:alpha-Fetoproteins