title: A deathly DNase activity for dicer.
abstract: Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity.
authors.affiliation: Sloan-Kettering Institute, Department of Developmental Biology, 1275 York Ave, Box 252, New York, NY 10065, USA.
authors.forename: Katsutomo
authors.initials: K
authors.lastname: Okamura
authors.forename: Eric C
authors.initials: EC
authors.lastname: Lai