Interactions between adenosine and nifedipine in the rat cerebral cortex.
Nifedipine inhibits the uptake of [(3)H]adenosine into rat cerebral cortical synaptosomes with an IC(50) value of 1.1 ?M. When applied by iontophoresis onto rat cerebral cortical neurons it potentiated the depressant effects of adenosine on spontaneous firing. Some of the calcium-antagonist actions of nifedipine may be mediated by adenosine.
Phillis
J W
JW
Department of Physiology, School of Medicine, Wayne State University, Detroit, MI 48201 USA.
Swanson
T H
TH
Barraco
R A
RA