Not all autophagy membranes are created equal.
During starvation, the cell recycles cytoplasmic material by sequestering it in double-membrane organelles, called autophagosomes, which eventually fuse with lysosomes. In this issue, Hailey et al. (2010) identify the outer membrane of mitochondria as a new source of autophagosomal membranes during starvation.
McEwan
David G
DG
Frankfurt Institute for Molecular Life Sciences, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. mcewan@biochem2.uni-frankfurt.de
Dikic
Ivan
I