Intranasal oxytocin modulates EEG mu/alpha and beta rhythms during perception of biological motion.
Oxytocin (OT) plays a determining role in social and pair bonding in many vertebrates and increasing evidence suggests it is a social hormone also in humans. Indeed, intranasal administration of OT modulates several social cognitive processes in humans. Electrophysiological studies in humans associated the suppression of EEG in the mu/alpha and beta bands with perception of biological motion and social stimuli. It has been suggested that mu and beta suppression over sensory-motor regions reflects a resonance system in the human brain analogous to mirror neurons in the monkey. We therefore hypothesized that OT, a social hormone, would enhance this suppression, hence, for the first time, link the action of this neuropeptide with a human correlate of mirror neuron activity. Twenty-four students were administered 24 IU of OT or placebo intranasally in a robust, double-blind within-subject design. 45 min later participants were shown a point-light display of continuous biological motion of a human figure's walk. In the 8-10 Hz (low alpha/mu band) and in the 15-25 Hz beta band, a significant main effect of treatment showed that suppression was significantly enhanced in the OT versus the placebo conditions and that this suppression was widespread across the scalp. These results are a first step linking OT to the modulation of EEG rhythms in humans, suggesting that OT may have a role in allocating cortical resources to social tasks partly mediated by mirror neuron activity.
Perry
Anat
A
The Department of Psychology, Hebrew University of Jerusalem, Mt. Scopus, 91905 Jerusalem, Israel. anat.perry@mail.huji.ac.il
Bentin
Shlomo
S
Shalev
Idan
I
Israel
Salomon
S
Uzefovsky
Florina
F
Bar-On
Dori
D
Ebstein
Richard P
RP
D000281:Administration, Intranasal; D000328:Adult; D000513:Alpha Rhythm / Q000187:drug effects*; D001611:Beta Rhythm / Q000187:drug effects*; D001931:Brain Mapping; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D008297:Male; D009039:Motion Perception / Q000187:drug effects*; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000187:drug effects; D012919:Social Behavior; D055815:Young Adult
D010121:Oxytocin