title: Persistence and predictors of abnormal glucose metabolisms in patients after acute stroke.
abstract: OBJECTIVE
  To determine the persistence of newly recognized abnormal glucose metabolism in patients following acute ischemic stroke and delineate the possible predictive factors for this persistence.
  
  
  METHODS
  A prospective observational study was performed. One hundred and twenty-three patients with acute first-ever ischemic stroke and no previous diagnosis of diabetes mellitus were enrolled consecutively. Information from baseline and laboratory tests was recorded. A standard oral glucose tolerance test was performed on the fourteenth day after onset and 3 months later, respectively.
  
  
  RESULTS
  One hundred and seven patients completed the study. Thirty-nine patients (36.3%) were diagnosed as having newly recognized diabetes on the 14th day and 28 patients (26.1%) after 3 months. Among the patients diagnosed as having diabetes or impaired glucose tolerance during hospitalization, 68.6% remained to present with abnormal glucose metabolism 3 months later. Lower post-load plasma glucose on the fourteenth day was detected as a predictor for aggravated glucose metabolism after 3 months of onset.
  
  
  CONCLUSIONS
  Majority of newly recognized abnormal glucose metabolism during hospitalization persisted 3 months later. Patients with lower post-load glucose level on the fourteenth day had higher risk for aggravated glucose metabolism 3 months later. Those with higher fasting glucose concentration on admission or higher 2 hour post-load plasma glucose on the fourteenth day had significantly high risk for diabetes after 3 months.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.forename: Huaguang
authors.initials: H
authors.lastname: Zheng
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Jing
authors.forename: Dejun
authors.initials: D
authors.lastname: Liang
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Kehui
authors.initials: K
authors.lastname: Dong
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Yang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D015984:Causality; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001786:Blood Glucose