Signal integration through blending, bolstering and bifurcating of intracellular information.
A cell's response to its environment is often determined by signaling through the actions of enzyme cascades. The ability to organize these enzymes into multiprotein complexes allows for a high degree of fidelity, efficiency and spatial precision in signaling responses.
Pawson
Catherine T
CT
Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, School of Medicine, Seattle, Washington, USA.
Scott
John D
JD
D000818:Animals; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D004798:Enzymes; D047908:Intracellular Signaling Peptides and Proteins; D009097:Multienzyme Complexes