Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.
With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
Zhou
Hailong
H
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, PR China.
Wu
Huifeng
H
Liao
Chunyang
C
Diao
Xiaoping
X
Zhen
Jiping
J
Chen
Linlin
L
Xue
Qinzhao
Q
D000818:Animals; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D009930:Organic Chemicals / Q000032:analysis / Q000633:toxicity*; D021381:Protein Transport; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism*; D014116:Toxicology / Q000379:methods*; D015027:Zebrafish / Q000378:metabolism
D004785:Environmental Pollutants; D009930:Organic Chemicals; D018336:Receptors, Aryl Hydrocarbon