title: Genetic structure of the Spanish population.
abstract: BACKGROUND
  Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.
  
  
  RESULTS
  In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.
  
  
  CONCLUSIONS
  In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
authors.affiliation: Department of Structural Genomics, Neocodex, Sevilla, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gayán
authors.forename: José J
authors.initials: JJ
authors.lastname: Galan
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Pérez
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Sáez
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Martínez-Larrad
authors.forename: Carina
authors.initials: C
authors.lastname: Zabena
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Rivero
authors.forename: Ana
authors.initials: A
authors.lastname: Salinas
authors.forename: Reposo
authors.initials: R
authors.lastname: Ramírez-Lorca
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Morón
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Royo
authors.forename: Concha
authors.initials: C
authors.lastname: Moreno-Rey
authors.forename: Juan
authors.initials: J
authors.lastname: Velasco
authors.forename: José M
authors.initials: JM
authors.lastname: Carrasco
authors.forename: Eva
authors.initials: E
authors.lastname: Molero
authors.forename: Carolina
authors.initials: C
authors.lastname: Ochoa
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Ochoa
authors.forename: Marta
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Reina
authors.forename: Rocío
authors.initials: R
authors.lastname: Pascual
authors.forename: Alejandro
authors.initials: A
authors.lastname: Romo-Astorga
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Susillo-González
authors.forename: Enrique
authors.initials: E
authors.lastname: Vázquez
authors.forename: Luis M
authors.initials: LM
authors.lastname: Real
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano-Ríos
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018628:Gene Dosage / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013030:Spain