title: Efficacy of Punica granatum extract on in-vitro and in-vivo control of Trichomonas vaginalis.
abstract: Trichomoniasis vaginalis is now an important worldwide health problem. Metronidazole has so far been used in treatment, but the metronidazole-resistant strains and unpleasant adverse effects have been developed. Treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. The last 7 years have seen over seven times as many publication indexed by Midline dealing with pomegranate (Punica granatum) than in all the years preceding them, because of this, and the virtual explosion of interest in pomegranate as a medicinal and nutritional product that has followed, this work is accordingly launched. Natural plant extract purified from Pomegranate (Roman) was in-vitro investigated for its efficacy against T. vaginalis on Diamond media. Besides, infection women (18/20) who accepted to be treated with P. granatum juice were completely curedand followed-up for two months. The anti-trichomoniasis vaginalis activity of P. granatum extract (in-vitro and in-vivo) gave very promising results.
authors.affiliation: Department of Parasitology, Faculty of Pharmacy, October 6 University, 6th October City.
authors.forename: Gehad M
authors.initials: GM
authors.lastname: El-Sherbini
authors.forename: Khadra M
authors.initials: KM
authors.lastname: Ibrahim
authors.forename: Eman T
authors.initials: ET
authors.lastname: El Sherbiny
authors.forename: Nevein M
authors.initials: NM
authors.lastname: Abdel-Hady
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
mesh_terms: D000328:Adult; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D029561:Lythraceae / Q000737:chemistry*; D008875:Middle Aged; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014247:Trichomonas Vaginitis / Q000188:drug therapy*; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts