Unveiling the secrets of the ancestral PI3 kinase Vps34.
Vps34 is the primordial member of the PI3 kinase family involved in vesicular trafficking, nutrient signaling, and autophagy. A report in Science unveils the Vps34 structure, providing new insights into the catalytic mechanism, explaining why Vsp34 is so difficult to inhibit, and facilitating design of chemical tools and potential drugs.
Workman
Paul
P
Cancer Research UK Centre for Cancer Therapeutics and Section of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, SM2 5NG, UK. paul.workman@icr.ac.uk
van Montfort
Rob L M
RL