title: The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial.
abstract: OBJECTIVE
  To test recolonization of periodontal lesions after full-mouth scaling and root planing (FM-SRP) or multiple session-SRP (MS-SRP) in a randomized clinical trial and whether FM-SRP and MS-SRP result in different clinical outcomes.
  
  
  METHODS
  Thirty-nine subjects were randomly assigned to FM-SRP or MS-SRP groups. At baseline and after 3 months, probing pocket depth (PPD), plaque index (PlI) and bleeding on probing (BoP) were recorded. At baseline, immediately after treatment, after 1, 2, 7, 14 and 90 days, paper point samples from a single site from the maxillary right quadrant were collected for microbiological analysis of five putative pathogens by polymerase chain reaction.
  
  
  RESULTS
  FM-SRP and MS-SRP resulted in significant reductions in PPD, BoP and PlI and the overall detection frequencies of the five species after 3 months without significant differences between treatments. Compared with MS-SRP, FM-SRP resulted in less recolonization of the five species, significantly for Treponema denticola, in the tested sites.
  
  
  CONCLUSIONS
  FM-SRP and MS-SRP result in overall clinically and microbiologically comparable outcomes where recolonization of periodontal lesions may be better prevented by FM-SRP.
authors.affiliation: Department of Periodontology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Vincent
authors.initials: V
authors.lastname: Zijnge
authors.forename: Henriette F
authors.initials: HF
authors.lastname: Meijer
authors.forename: Mady-Ann
authors.initials: MA
authors.lastname: Lie
authors.forename: Jan A H
authors.initials: JA
authors.lastname: Tromp
authors.forename: John E
authors.initials: JE
authors.lastname: Degener
authors.forename: Hermie J M
authors.initials: HJ
authors.lastname: Harmsen
authors.forename: Frank
authors.initials: F
authors.lastname: Abbas
mesh_terms: D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000254:growth & development; D001419:Bacteria / Q000145:classification / Q000254:growth & development*; D001439:Bacteroides / Q000254:growth & development; D055113:Chronic Periodontitis / Q000382:microbiology* / Q000628:therapy; D002985:Clinical Protocols; D015169:Colony Count, Microbial; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000382:microbiology / Q000628:therapy; D016967:Fusobacterium nucleatum / Q000254:growth & development; D005884:Gingival Hemorrhage / Q000382:microbiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000254:growth & development; D016745:Root Planing / Q000379:methods*; D013357:Subgingival Curettage / Q000379:methods; D016896:Treatment Outcome; D048373:Treponema denticola / Q000254:growth & development