title: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults characterized by high viral genome load within circulating natural killer cells.
abstract: Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.
authors.affiliation: School of Cancer Sciences, University of Birmingham, Edgbaston, UK. c.p.fox@bham.ac.uk
authors.forename: C P
authors.initials: CP
authors.lastname: Fox
authors.forename: C
authors.initials: C
authors.lastname: Shannon-Lowe
authors.forename: P
authors.initials: P
authors.lastname: Gothard
authors.forename: B
authors.initials: B
authors.lastname: Kishore
authors.forename: J
authors.initials: J
authors.lastname: Neilson
authors.forename: N
authors.initials: N
authors.lastname: O'Connor
authors.forename: M
authors.initials: M
authors.lastname: Rowe
mesh_terms: D001856:Bone Marrow Examination; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019562:Viral Load; D055815:Young Adult