In vitro differential phenotypic characteristics among Type-II Toxoplasma gondii strains from congenital toxoplasmosis in humans.
In France, more than 80% of human congenital toxoplasmosis is attributable to Toxoplasma gondii strains belonging to the type-II lineage, whereas 3 main lineages have been described in Europe. Cell invasion, parasite replication, and cyst formation of type-II strains isolated from congenital infections were compared in a human cell model. The phenotype patterns of the 4 type-II strains studied differed from each other; the 2 strains responsible for asymptomatic infection formed significantly fewer cysts than the 2 strains isolated from symptomatic toxoplasmosis. The capacity to form cysts was different among the type-II strains studied and may be related to the clinical form.
Brenier-Pinchart
M P
MP
Laboratoire Adaptation et Pathogénie des Microorganismes, UMR 5163 CNRS, Université Joseph Fourier, Grenoble 1, BP 170, F-38042, Grenoble cedex 9, France.
Bertini
R L
RL
Maubon
D
D
Pelloux
H
H
D000704:Analysis of Variance; D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000469:parasitology; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D051379:Mice; D010641:Phenotype; D014122:Toxoplasma / Q000145:classification* / Q000472:pathogenicity / Q000502:physiology; D014125:Toxoplasmosis, Congenital / Q000469:parasitology*; D014774:Virulence
D007371:Interferon-gamma