An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.
Transcriptional co-activators, co-repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARgamma. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate decision-making and adipogenesis. This review focuses on bromodomain-containing protein complexes recently shown to play a critical role in adipogenesis. Deeper understanding of these pathways is likely to have major impact on treatment of obesity-associated diseases, including metabolic syndrome, cardiovascular disease and Type 2 diabetes. The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity.
Denis
Gerald V
GV
Cancer Research Center, Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA. gdenis@bu.edu
Nikolajczyk
Barbara S
BS
Schnitzler
Gavin R
GR
D050156:Adipogenesis / Q000235:genetics*; D000818:Animals; D002843:Chromatin / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000235:genetics; D017434:Protein Structure, Tertiary; D014158:Transcription, Genetic
D002843:Chromatin; D009687:Nuclear Proteins