title: A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin-converting enzyme.
abstract: We described a case of neurosarcoidosis with necrotizing sarcoid granulomatosis in a 22-year-old man. Contrast-enhanced brain computed tomography scan and magnetic resonance imaging showed intracerebral multiple nodular lesions. Noncaseating and partial necrotizing granulomas were detected in the specimen resected by neurosurgery. In addition, immunohistochemical examination revealed the expression of angiotensin-converting enzyme in necrotizing granuloma. Thus, these findings were consistent with neurosarcoidosis. Clinical and pathological presentation, immunological features, and treatment modalities of neurosarcoidosis are discussed.
authors.affiliation: Department of Disease Control and Homeostasis, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kitajima
authors.forename: Norihiko
authors.initials: N
authors.lastname: Sakai
authors.forename: Kengo
authors.initials: K
authors.lastname: Furuichi
authors.forename: Miki
authors.initials: M
authors.lastname: Tomokage
authors.forename: Akinori
authors.initials: A
authors.lastname: Hara
authors.forename: Kiyoki
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Seiko
authors.initials: S
authors.lastname: Sawada Kitamura
authors.forename: Yoh
authors.initials: Y
authors.lastname: Zen
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakada
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D002493:Central Nervous System Diseases / Q000150:complications / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D004827:Epilepsy / Q000150:complications / Q000473:pathology; D006099:Granuloma / Q000150:complications / Q000201:enzymology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D013902:Radiography, Thoracic; D012507:Sarcoidosis / Q000150:complications / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D007703:Peptidyl-Dipeptidase A