title: Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
abstract: Several thiosemicarbazones (7 and 8), 1,3-thiazolidin-4-ones (9, 10, 13, 14) and 2-thioxo-1,3-imidazolidin-4-ones (11) have been prepared starting from 8-bromo-7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-1-benzopyran-6-carbaldehyde (3) and its 4-thio analogue (4). The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures. The neurotoxicity was assessed using the rota-rod test. Some of the tested compounds displayed potent anticonvulsant activity in the scPTZ test.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Fatma Abd El-Fattah
authors.initials: FA
authors.lastname: Ragab
authors.forename: Ghaneya Sayed
authors.initials: GS
authors.lastname: Hassan
authors.forename: Hanan Al-Sayed
authors.initials: HA
authors.lastname: Abu Yossef
authors.forename: Tawfeek Ahmed Ali
authors.initials: TA
authors.lastname: Yahya
authors.forename: Hekma A
authors.initials: HA
authors.lastname: Abd El-Latif
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology*; D004597:Electroshock; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced / Q000523:psychology; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D001578:Benzopyrans; D007202:Indicators and Reagents; D014635:Valproic Acid; D010672:Phenytoin; D010433:Pentylenetetrazole