Macromolecular composition and drug-loading effect on the delivery of paclitaxel and folic acid from acrylic matrices.
Drug delivery systems based on synthetic polymers are widely employed in the treatment of several pathologies. In particular, the use of implantable devices able to release one or more active principles in a topic site with a controlled delivery kinetic represents an important improvement in this field. However, the release kinetic, that could be affected by different parameters, like polymer composition or chemical nature and initial drug loading, represents one of the problems related to the implantation of delivery systems. In this study, acrylic membranes with different macromolecular composition were prepared and studied analyzing delivery kinetic properties. Drug delivery systems were prepared using as matrix the copolymer poly(methylmethacrylate-co-butylmethacrylate) in three different compositions and folic acid (less hydrophobic) or Paclitaxel (more hydrophobic) as drugs, to evaluate the effect of macromolecular composition and hydrophilicity degree on the release properties. In addition, the effect of the initial drug loading was considered, loading drug delivery systems with four different initial drug percentages. Results showed a direct dependence of kinetics from macromolecular composition, hydrophilicity degree of solutes, and initial drug loading, allowing one to conclude that it is possible to design and to develop drug delivery systems starting from poly(methylmethacrylate-co-butylmethacrylate) matrices with specific properties by varying these three parameters.
Gagliardi
M
M
Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, via Diotisalvi 2, 56126 Pisa, Italy. m.gagliardi@diccism.unipi.it
Silvestri
D
D
Cristallini
C
C
D000180:Acrylic Resins / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D055598:Chemical Phenomena; D004058:Diffusion; D004337:Drug Carriers / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D006397:Hematinics / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008567:Membranes, Artificial; D008956:Models, Chemical; D009994:Osmolar Concentration; D017239:Paclitaxel / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000032:analysis
D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D006397:Hematinics; D008567:Membranes, Artificial; D011109:Polymethacrylic Acids; C521063:poly(methyl methacrylate-co-butyl methacrylate); D014867:Water; D005492:Folic Acid; D017239:Paclitaxel