title: Hybrid liposomes inhibit the growth of cholangiocarcinoma by induction of cell cycle arrest in G1 phase.
abstract: Specific accumulation and cell cycle arrest were observed in human cholangiocarcinoma cells by hybrid liposomes composed of 90 mol% L-alpha-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(21)dodecyl ether (C(12)(EO)(21)) without affecting normal cholangiocytes.
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Towata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Komizu
authors.forename: Ryusho
authors.initials: R
authors.lastname: Kariya
authors.forename: Shinya
authors.initials: S
authors.lastname: Suzu
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Naoya
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Chaisiri
authors.initials: C
authors.lastname: Wongkham
authors.forename: Sopit
authors.initials: S
authors.lastname: Wongkham
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
authors.forename: Seiji
authors.initials: S
authors.lastname: Okada
mesh_terms: D001653:Bile Ducts, Intrahepatic / Q000166:cytology / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D018281:Cholangiocarcinoma / Q000188:drug therapy* / Q000473:pathology; D004134:Dimyristoylphosphatidylcholine; D016193:G1 Phase / Q000187:drug effects*; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols; D014407:Tumor Cells, Cultured
chemical_list: D008081:Liposomes; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine