title: S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus.
abstract: Novel S-aryltriazole acyclonucleosides were designed as structural analogs based on the previously identified antiviral aryltriazole acyclonucleosides in our laboratories. These S-aryltriazole nucleosides were synthesized in excellent yields via S(N)Ar-mediated S-arylation, followed by subsequent ammonolysis. X-ray structural analysis revealed special structural feature brought by the S-linkage, which may represent an unfavorable factor contributing to the lack of anti-HCV activity for this family of triazole nucleosides.
authors.affiliation: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Mei
authors.initials: M
authors.lastname: Cong
authors.forename: Alain
authors.initials: A
authors.lastname: Maggiani
authors.forename: Pieter
authors.initials: P
authors.lastname: Leyssen
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D014230:Triazoles; D013455:Sulfur