Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.
A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.
Cho
Tang Peng
TP
Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China. tangpc@shhrp.com
Gang
Lin Zhi
LZ
Long
Yang Fang
YF
Yang
Wang
W
Qian
Wang
W
Lei
Zhang
Z
Jing
Luo Jing
LJ
Ying
Feng
F
Ke
Yan Pang
YP
Ying
Leng
L
Jun
Feng
F
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D051379:Mice; D008815:Mice, Inbred Strains; D009795:Octanes / Q000138:chemical synthesis* / Q000494:pharmacology
D001643:Bridged Bicyclo Compounds; D054873:Dipeptidyl-Peptidase IV Inhibitors; D009795:Octanes