title: Cytotoxic C(35) terpenoid cryptotrione from the bark of Cryptomeria japonica.
abstract: A novel C(35)-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC(50) value of 6.44 +/- 2.23 microM.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan 106, ROC.
authors.forename: Cheng-Chi
authors.initials: CC
authors.lastname: Chen
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Wu
authors.forename: Ning-Sun
authors.initials: NS
authors.lastname: Yang
authors.forename: Jang-Yang
authors.initials: JY
authors.lastname: Chang
authors.forename: Ching-Chuan
authors.initials: CC
authors.lastname: Kuo
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032485:Cryptomeria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C551665:cryptotrione; D005047:Etoposide