title: Progressive multifocal leukoencephalopathy in a patient with multiple myeloma.
abstract: Progressive multifocal leukoencephalopathy (PML) is a neurological disease that affects immunodeficient patients. We describe here a case of 64-year-old man with IgD type multiple myeloma (MM) who developed progressive neurological symptoms. T(2)-weighted magnetic resonance imaging of the brain showed a hyperintense non-enhancing lesion in the left frontal lobe, and analysis of the cerebrospinal fluid by polymerase chain reaction revealed the presence of John Cunningham virus (JCV) DNA. Histopathological analysis of the autopsy brain specimen with in situ hybridization assay revealed the presence of JCV DNA in the nuclei of oligodendroglia. PML in a patient with MM is rare. However, this case report suggests that PML should be suspected and relevant diagnostic examinations should be performed when MM patients present with neurological symptoms.
authors.affiliation: Department of Hematology, Tokuyama Central Hospital, 1-1 Koda, Shunan, Yamaguchi, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Akiyama
authors.forename: Toru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Sinjo
authors.initials: S
authors.lastname: Nomura
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hatao
mesh_terms: D001921:Brain / Q000473:pathology / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*