Influence of exogenous gangliosides (G(M1), G(D1a), G(Mix)) on a Ca(2+)-activated Mg(2+)-dependent ATPase in cellular and subcellular brain fractions of the djungarian dwarf hamster (Phodopus sungorus).
The influence of 150 nM exogenously-added gangliosides (G(M1), G(D1a), G(Mix)) on a Ca(2+)-activated, Mg(2+)-dependent ATPase was investigated in cellular and subcellular fractions (P1-fraction, synaptosomal fraction, synaptic membranes) from whole brain, cortex, cerebellum and brain stem of the djungarian dwarf hamster (Phodopus sungorus). Gangliosides are effective at this concentration in stimulating the enzyme activity in all fractions from whole brain. Inhomogenous results (stimulation, inhibition and no effects), however, were obtained in the different individual brain regions.
Slenzka
K
K
Institute of Zoology, University of Stuttgart-Hohenheim, Garbenstrasse 30, D-7000 Suttgart 70 (Hohenheim), F.R.G.
Appel
R
R
Rahmann
H
H