Dammarane saponins from Gynostemma pentaphyllum.
Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4, 6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7.
Hu
Yongmei
Y
Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Ip
Fanny C F
FC
Fu
Guangmiao
G
Pang
Haihong
H
Ye
Wencai
W
Ip
Nancy Y
NY
D000818:Animals; D002236:Carbohydrate Conformation; D002460:Cell Line; D002478:Cells, Cultured; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D029774:Gynostemma / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010766:Phosphorylation; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*; D000097669:Dammaranes
D048049:Extracellular Signal-Regulated MAP Kinases; D012503:Saponins; D014315:Triterpenes; D000097669:Dammaranes