[Dynamics of cytokines in blood and liquor at the spinal injured patients.].
Authors followed the increase of cytokines concentration in blood and liquor at spine injured patients. The degree of the neurological damage was classified according to Frankel scale. Mediators: IL-1, IL-2, IL-6, TNF-alfa, Cortisol were investigated. No significant response of IL-1, IL-2, TNF-alfa to the spinal injury was documented. The Cortisol levels in blood and liquor reached vallues of 100 pg/ml. But no statistical correlation between the Cortisol level and various degrees of spinal neurological damage was identified. The increase in Cortisol concentration can be explained by the stress reaction of the organism. The IL-6 blood and liquor concentrations reached extremly high vallues. We certified a significant relationship between the IL-6 level and the neurological damage of the spinal cord. In prognostic point of view we conclude that the lower increase of IL-6 means: a)lower degree of the neurological damage of the spinal cord classified by Frankel; b)higher percentage of neurological improvement. Key words: cytokines, spinal injury, spinal cord lesion.
Visna
P
P
Spinální jednotka Urazové nemocnice, Brno.
Wendsche
P
P
Svoboda
P
P
Kantorová
I
I