title: Effect of dietary tea polyphenols on growth performance and cell-mediated immune response of post-weaning piglets under oxidative stress.
abstract: To gain insights into the effects of tea polyphenols (TP) on growth performance and cell-mediated immune response of piglets under oxidative stress, an oxidative stress model was established by intraperitoneally injecting weaned piglets with diquat. After intake of either basal diet or TP-supplemented diet for 7 d, half of the piglets in each group were challenged with diquat. Results showed that dietary TP alleviated growth depression to some extent. A T lymphocyte transformation test (LTT) demonstrated that TP promoted the proliferation and activation of T lymphocytes. The ratio of CD4+/CD8+ was elevated, indicating a recovering tendency from immune damages caused by oxidative stress. The increment of pro-inflammatory IL-1 caused by oxidative stress was attenuated, and the concentration of serum IFN-gamma was decreased by TP-supplementation. However, the serum concentrations of anti-inflammatory cytokine, such as IL-4, were greatly enhanced by TP, which suggested an immune shift from Th1 to Th2. These findings supported the immunomodulatory potential of TP for piglets subjected to oxidative stress.
authors.affiliation: Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Ya'an, Sichuan, P.R. China.
authors.forename: Qilan
authors.initials: Q
authors.lastname: Deng
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Bing
authors.initials: B
authors.lastname: Yu
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Keying
authors.initials: K
authors.lastname: Zhang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Ding
authors.forename: Daiwen
authors.initials: D
authors.lastname: Chen
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D004032:Diet / Q000662:veterinary*; D004178:Diquat; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D013552:Swine / Q000254:growth & development* / Q000276:immunology; D014886:Weaning
chemical_list: D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D004178:Diquat