Acute interstitial nephritis associated with ulcerative colitis.
Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.
Tokuyama
Hirobumi
H
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. hirobumitokuyama@aol.com
Wakino
Shu
S
Konishi
Konosuke
K
Hashiguchi
Akinori
A
Hayashi
Koichi
K
Itoh
Hiroshi
H
D000293:Adolescent; D003093:Colitis, Ulcerative / Q000150:complications* / Q000276:immunology / Q000473:pathology; D003404:Creatinine / Q000097:blood; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001613:beta 2-Microglobulin / Q000097:blood
D001613:beta 2-Microglobulin; D003404:Creatinine