Toxicokinetics of aflatoxin in pregnant mice.
Our objective was to study the toxicokinetics of aflatoxin (AF) in pregnant mice. Aflatoxin B1 (AFB1) was administered intraperitoneally (IP) to groups of pregnant mice in single doses of 20 mg/kg on gestation day (GD) 13 and orally at the same gestational age. Controls received (IP and oral) a proportionate volume of solvent only. Maternal blood was collected at 15, 30, 45, 60, 90, 120, and 150 minutes posttreatment. Their AFB1 contents were determined. Aflatoxin B1 concentrations following maternal exposure to AFB1 were highly correlated with time after exposure. The serum concentrations were predictable and the highest serum levels were seen immediately at 15 minutes in mice given AFs IP and at 30 minutes in those given it orally. The absorption was 5.0 microg/min and elimination was 3.0 microg/min. The toxicokinetics of AFB1 have been delineated. Aflatoxins are easily and rapidly absorbed both from the gastrointestinal tract (GI) tract and through the peritoneum.
Bastaki
Salim A
SA
Department of Paediatrics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Osman
Nawal
N
Kochiyil
Jose
J
Shafiullah
Mohamed
M
Padmanabhan
Rengasamy
R
Abdulrazzaq
Yousef M
YM
D016604:Aflatoxin B1 / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D000818:Animals; D016022:Case-Control Studies; D005260:Female; D018811:Maternal Exposure; D051379:Mice; D011247:Pregnancy
D016604:Aflatoxin B1