[Effectiveness and safety of using 6% hydroxyethyl starch 130/04 and 4% modified liquid gelatin in neurosurgical patients with massive intraoperative blood loss].
The results of using three infusion solutions, such as 6% hydroxyexyethyl starch (HES) 200/0.5 (HaesSteril), HES 130/0.4 (Voluven), and 4% modified gelatin solution (Gelofusin), were compared in 33 patients with neurosurgical diseases of the brain (supratentorial meningovascular tumors) and predictable massive intraoperative blood loss during acute isovolemic hemodilution and compensation for later blood loss. The evaluation criteria were volemic, hemostatic and cerebrovascular effects. The most marked and longest volemic effect was observed in the Voluven group. The least hemostatic changes were seen in the Gelofusin group. The findings suggest that among the test infusion solutions, Voluven is most effective and Gelofusion is safest.
Israelian
L A
LA
Lubnin
A Iu
AIu
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005260:Female; D005780:Gelatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006438:Hemodilution; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013386:Succinates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015173:Supratentorial Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D005780:Gelatin