Pot1 and telomere maintenance.
Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice.
Baumann
Peter
P
Howard Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, MO 64110, USA. peb@stowers.org
Price
Carolyn
C
D000818:Animals; D005656:Fungal Proteins / Q000235:genetics; D020440:Gene Duplication; D017125:Genes, Protozoan; D006801:Humans; D051379:Mice; D009348:Nematoda / Q000235:genetics; D010944:Plants / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D000089804:Shelterin Complex; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000502:physiology*; D034501:Telomere-Binding Proteins / Q000235:genetics*; D015003:Yeasts / Q000235:genetics
D005656:Fungal Proteins; C440849:POT1 protein, human; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D019098:Telomerase