[Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient].
A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.
Aardema
Heleen
H
Universitair Medisch Centrum Groningen, Afd. Intensive Care Volwassenen, The Netherlands. h.aardema@int.umcg.nl
Tulleken
Jaap E
JE
van den Biggelaar
Ries J M
RJ
Wolters
Bert A
BA
de Jager
Corine M
CM
Boucher
Charles A B
CA
Riezebos-Brilman
Annelies
A
D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy* / Q000821:virology*; D053243:Zanamivir / Q000494:pharmacology / Q000627:therapeutic use
D000998:Antiviral Agents; D053139:Oseltamivir; D053243:Zanamivir