title: Synthesis and antimicrobial activities of two novel amino sugars derived from chloraloses.
abstract: The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-beta-L-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-alpha-D-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans.
authors.affiliation: Department of Chemistry, Sciences and Arts Faculty, Celal Bayar University, Muradiye, Manisa, Turkey. nilgun.yenil@bayar.edu.tr
authors.forename: Nilgün
authors.initials: N
authors.lastname: Yenil
authors.forename: Emriye
authors.initials: E
authors.lastname: Ay
authors.forename: Kadir
authors.initials: K
authors.lastname: Ay
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oskay
authors.forename: Jacques
authors.initials: J
authors.lastname: Maddaluno
mesh_terms: D000606:Amino Sugars / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002698:Chloralose / Q000031:analogs & derivatives*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
chemical_list: D000606:Amino Sugars; D000890:Anti-Infective Agents; D002698:Chloralose