title: [Glucagonoma without glucagonoma syndrome].
abstract: BACKGROUND
  Glucagonomas are rare, frequently malignant tumours, arising from the Langerhans' islets of the pancreas. They usually secrete large amounts of glucagon that can cause a characteristic "glucagonoma syndrome", which includes necrolytic migratory erythema, glucose intolerance or diabetes, weight loss and sometimes, normochromic normocytic anaemia, stomatitis or cheilitis, diarrhoea or other digestive symptoms, thoromboembolism, hepatosplenomegaly, depression or other psychiatric and paraneoplastic symptoms. In certain cases, some or all glucagonoma symptoms may appear late, or even may be completely absent.
  
  
  METHODS
  The authors present a 43-year-old woman in whom an investigation for abdominal pain revealed a tumour of the body of the pancreas. During operation, the tumour of the body of the pancreas extending to the mesentery measuring 85 x 55 x 55 mm was excised. Histology and immunohistochemistry showed malignant glucagonoma, with co-expression of somatostatin in about 5% and pancreatic polypeptide in a few tumour cells. The recovery was uneventful. The patient stayed symptom-free with no signs of local recurrence or distant diseases 15 years after surgery.
  
  
  CONCLUSIONS
  Glucagonoma syndrome may be absent in glucagonoma tumour patients so that in unclear pancreatic tumours the clinician should frequently request the serum hormone level (including glucagon) measurement by radioimmunoassay and the pathologist should perform immunohistochemistry investigation. Those two would probably result in discovery of more glucagonomas and other neuroendocrine tumours without characteristic clinical syndromes.
authors.forename: Radoje
authors.initials: R
authors.lastname: Colović
authors.forename: Slavko
authors.initials: S
authors.lastname: Matić
authors.forename: Marjan
authors.initials: M
authors.lastname: Micev
authors.forename: Nikica
authors.initials: N
authors.lastname: Grubor
authors.forename: Stojan
authors.initials: S
authors.lastname: Latincić
mesh_terms: D000328:Adult; D005260:Female; D005935:Glucagonoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis*