title: Acute effects of ammonia on the enzymes of citric acid cycle in rat brain.
abstract: Activities of the enzymes of citric acid cycle were determined along with aspartate and alanine aminotransferases and NADP(+)-isocitrate dehydrogenase in the brains of rats treated with an acute dose of ammonium acetate and compared with those of normal animals. Elevation in the activities of pyruvate, ?-ketoglutarate and succinate dehydrogenases and citrate synthase was observed in hyperammonemic animals. The activities of malate, NADP(+)-isocitrate dehydrogenases and aminotransferases decreased under these conditions. The results suggest that ammonia toxicity might not be due to the depletion of ?-ketoglutarate from citric acid cycle.
authors.affiliation: School of Life Sciences, University of Hyderabad, Hyderabad-500 134 India.
authors.forename: L
authors.initials: L
authors.lastname: Ratnakumari
authors.forename: G Y
authors.initials: GY
authors.lastname: Subbalakshmi
authors.forename: C R
authors.initials: CR
authors.lastname: Murthy