title: Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways.
abstract: We investigated the phagocytosis-enhancing activity of green tea polyphenols, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) catechin (+C) and strictinin, using VD3-differentiated HL60 cells. EGCG, EGC, ECG and strictinin, but not EC and +C, increased the phagocytic activity of macrophage-like cells, and a caspase inhibitor significantly inhibited phagocytic activities. These results suggest that the pyrogallol-type structure in green tea polyphenols may be important for enhancement of the phagocytic activity through caspase signaling pathways.
authors.affiliation: National Institute of Vegetable and Tea Science, NARO, 2769 Kanaya, Shimada, Shizuoka, 428-8501, Japan, monobe@affrc.go.jp.
authors.forename: Manami
authors.initials: M
authors.lastname: Monobe
authors.forename: Kaori
authors.initials: K
authors.lastname: Ema
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tokuda
authors.forename: Mari
authors.initials: M
authors.lastname: Maeda-Yamamoto