Cellular homeostasis: coping with ER overload during an immune response.
Host cells secrete antimicrobial proteins en masse to counter extracellular pathogens, placing a strain on the endoplasmic reticulum. The interplay between defence and cellular homeostasis has now been dissected genetically in Caenorhabditis elegans.
Ewbank
Jonathan J
JJ
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, 13288 Marseille cedex 9, France. ewbank@ciml.univ-mrs.fr
Pujol
Nathalie
N
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006706:Homeostasis; D007113:Immunity, Innate