title: Rong's numbers: accelerating progress in HCV therapeutic research.
abstract: Rong and colleagues have applied a mathematical model of hepatitis C virus (HCV) replication to experimental data from initial clinical investigations of HCV protease inhibitors. In this Perspective, we discuss how mathematical modeling and other modern translational research tools and approaches can be used to expedite drug development with well-designed combination clinical trials that test drugs from multiple collaborators.
authors.affiliation: Division of Infectious Diseases, University of California, San Diego, San Diego, CA 92093, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Wyles
authors.forename: Robert T
authors.initials: RT
authors.lastname: Schooley
mesh_terms: D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
chemical_list: D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins