Missing pieces in the Parkinson's disease puzzle.
Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.
Obeso
Jose A
JA
Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, Center for Applied Medical Research, Pamplona, Spain. obeso@unav.es
Rodriguez-Oroz
Maria C
MC
Goetz
Christopher G
CG
Marin
Concepcion
C
Kordower
Jeffrey H
JH
Rodriguez
Manuel
M
Hirsch
Etienne C
EC
Farrer
Matthew
M
Schapira
Anthony H V
AH
Halliday
Glenda
G
D000818:Animals; D018450:Disease Progression; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D013378:Substantia Nigra / Q000503:physiopathology