A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.
Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne 'click' reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.
Moses
John E
JE
The School of Chemistry, University of Nottingham, University Park, Nottingham, UK NG7 2RD. john.moses@nottingham.ac.uk
Ritson
Dougal J
DJ
Zhang
Fengzhi
F
Lombardo
Caterina Maria
CM
Haider
Shozeb
S
Oldham
Neil
N
Neidle
Stephen
S
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009691:Nucleic Acid Denaturation; D021241:Spectrometry, Mass, Electrospray Ionization; D044366:Transition Temperature; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D008024:Ligands; D014230:Triazoles; D003300:Copper; D004247:DNA