Comparison of macular thickness measurement and segmentation error rate between stratus and fourier-domain optical coherence tomography.
OBJECTIVE
To compare macular thickness measurements and segmentation error rates between Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Inc., Dublin, CA), and Fourier-domain OCT (RTVue, Optovue, Inc., Fremont, CA).


METHODS
A retrospective study was performed of 93 normal and pathologic eyes from 79 subjects imaged with both OCT instruments on the same day. Both the macular thickness measurement for each Early Treatment Diabetic Retinopathy Study (ETDRS) zone and the incidence of segmentation error in the central macula between the two instruments were compared.


RESULTS
Macular thickness measurements for all nine ETDRS zones were higher with RTVue compared with Stratus OCT (P < .01). Linear regression analysis showed the highest correlation in the central macula (R(2) = 0.88), with progressively lower correlation peripherally. The overall segmentation error rate was 29% with Stratus OCT versus 32% with RTVue (P > .05).


CONCLUSIONS
Macular thickness measurement was greater with RTVue than with Stratus OCT in all ETDRS areas, with the best correlation seen in the central macula. No difference in segmentation error rate was noted between the two instruments.
Modjtahedi
Sara
S
Department of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, California, USA.
Chiou
Christine
C
Modjtahedi
Bobeck
B
Telander
David G
DG
Morse
Lawrence S
LS
Park
Susanna S
SS
D016477:Artifacts; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*