The inverted Formin INF2 sorts it out.
A new study published in this issue of Developmental Cell by Madrid et al. surprisingly reveals that both the actin polymerization and depolymerization activities of human inverted formin INF2 and its interactions with MAL2 and active Cdc42 are critical for basolateral-to-apical transcytosis and lumen formation in polarized epithelial cells.
Breitsprecher
Dennis
D
Institute of Biophysical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
Faix
Jan
J