Parahippocampal corpora amylacea: case report.
OBJECTIVE
Corpora amylacea (CA) normally accumulate within perivascular, subpial, and subependymal astrocytic processes. CA are associated with a number of conditions including normal aging, hippocampal sclerosis associated with temporal lobe epilepsy, multiple sclerosis, Lafora-type progressive myoclonic epilepsy, and adult polyglucosan body disease. Reports of massive localized accumulation of CA in the brain outside of these conditions are rare.


METHODS
A 49-year-old woman, with a long-standing history of migraine headaches, presented to her primary care provider for increased headache duration. Brain magnetic resonance imaging (MRI) revealed a left parahippocampal lesion, suggestive of low-grade glioma.


METHODS
Given the MRI suggestive of left parahippocampal glioma, left-sided frontotemporal craniotomy was performed for resection of the lesion. Specimens obtained during the operation revealed focal high-density accumulation of CA with no evidence of neoplasm, ischemia, or hypoxic injury.


CONCLUSIONS
This case illustrates the possibility that localized high-density CA accumulation can present as an intrinsic lesion on brain MRI. CA should be included in the differential diagnosis for patients presenting with brain MRI suggestive of nonenhancing space-occupying lesions.
Abel
Taylor J
TJ
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.
Hebb
Adam O
AO
Keene
C Dirk
CD
Born
Donald E
DE
Silbergeld
Daniel L
DL
D003937:Diagnosis, Differential; D005260:Female; D005936:Glucans / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D008881:Migraine Disorders / Q000378:metabolism / Q000473:pathology; D020534:Parahippocampal Gyrus / Q000378:metabolism* / Q000473:pathology*
D005936:Glucans; C083094:polyglucosan