title: Allogeneic hematopoietic stem cell transplant following chemotherapy containing l-asparaginase as a promising treatment for patients with relapsed or refractory extranodal natural killer/T cell lymphoma, nasal type.
abstract: The prognosis of advanced extranodal NK/T cell lymphoma (ENKTL) is poor. Allogeneic hematopoietic stem cell transplant (allo-HSCT) has been suggested to be a promising treatment for this disease, but its utility has yet to be established. Here we retrospectively analyzed five cases of ENKTL treated with allo-HSCT in our institute. After induction chemotherapy, disease status at allo-HSCT was second CR in three patients and refractory in two patients. All patients received a myeloablative conditioning regimen, and GVHD prophylaxis consisted of tacrolimus or cyclosporine with short-term methotrexate. Only one patient who received conventional induction chemotherapy developed severe complications, which needed long-term treatment, while others who received chemotherapy containing l-asparaginase did not have severe complications. There were no cases of treatment-related mortality, and all patients survived without disease for a median follow-up period of 1911 days. These results suggested that allo-HSCT following l-asparaginase-containing induction chemotherapy might improve the outcome of advanced ENKTL.
authors.affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Joji
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tohmiya
authors.forename: Minami F
authors.initials: MF
authors.lastname: Yamada
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ohguchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okitsu
authors.forename: Noriko
authors.initials: N
authors.lastname: Fukuhara
authors.forename: Rie
authors.initials: R
authors.lastname: Ohba-Ohtsuka
authors.forename: Katsura
authors.initials: K
authors.lastname: Kohata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishizawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Kameoka
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D055611:Natural Killer T-Cells / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy*; D012074:Remission Induction; D012189:Retrospective Studies; D016879:Salvage Therapy; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001215:Asparaginase; D008727:Methotrexate