title: Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties.
abstract: New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: Alla A
authors.initials: AA
authors.lastname: Kicha
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Ivanchina
authors.forename: Trinh T T
authors.initials: TT
authors.lastname: Huong
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Fedorov
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dyshlovoy
authors.forename: Pham Q
authors.initials: PQ
authors.lastname: Long
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D016328:NF-kappa B / Q000235:genetics; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*; D018808:Transcription Factor AP-1 / Q000235:genetics; D015533:Transcriptional Activation / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B; D012503:Saponins; D018808:Transcription Factor AP-1; D016159:Tumor Suppressor Protein p53; C551832:archasteroside A; C551833:archasteroside B; C513250:regularoside A