Rong's numbers: accelerating progress in HCV therapeutic research.
Rong and colleagues have applied a mathematical model of hepatitis C virus (HCV) replication to experimental data from initial clinical investigations of HCV protease inhibitors. In this Perspective, we discuss how mathematical modeling and other modern translational research tools and approaches can be used to expedite drug development with well-designed combination clinical trials that test drugs from multiple collaborators.
Wyles
David L
DL
Division of Infectious Diseases, University of California, San Diego, San Diego, CA 92093, USA.
Schooley
Robert T
RT
D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins