Post-translational modifications in signal integration.
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.
Deribe
Yonathan Lissanu
YL
Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Germany.
Pawson
Tony
T
Dikic
Ivan
I
D000818:Animals; D004249:DNA Damage / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D066246:ErbB Receptors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology*
D021382:Protein Sorting Signals; D018124:Receptors, Tumor Necrosis Factor; D066246:ErbB Receptors; D010100:Oxygen