title: Biomarkers of metastatic melanoma.
abstract: Melanoma, one of the most aggressive forms of human cancer, has undergone an alarming increase in incidence in recent years. Early detection is a prerequisite for proper diagnosis and therapy orientation. Soluble biomarkers are an important tool for early diagnosis. Markers that are associated with melanocyte functions imply the enzymes involved in melanin synthesis and the melanin-related metabolites. Proteins such as autocrine melanocyte cell growth factor and melanoma metastasis suppressor have gained attention in the biomarkers domain. The antimelanoma immune response elicited in patients can not only provide new biomarkers but important therapeutic approaches in specific treatments. All the molecules generated during the metastasis process, invasion of neighboring tissue, angiogenesis, invading lymphatic/blood vessels and establishing new tumors at a distant site, are targets for biomarker discovery.
authors.affiliation: 'Victor Babes' National Institute of Pathology, Immunology Department, 99-101 Splaiul Independentei, 050096 Bucharest, Romania. neagu.monica@gmail.com
authors.forename: Monica
authors.initials: M
authors.lastname: Neagu
authors.forename: Carolina
authors.initials: C
authors.lastname: Constantin
authors.forename: Gina
authors.initials: G
authors.lastname: Manda
authors.forename: Irina
authors.initials: I
authors.lastname: Margaritescu