Gastric emptying of multi-particulate dosage forms.
The evidence in the literature for the concept that multi-particulate dosage forms below a specific size empty from the stomach as if they were liquids and hence have the potential to provide the best solution to the formulation of controlled release oral dosage forms, has been considered. There is some evidence that particles less than 1.0mm provide a more rapid response than larger size particles but there is also evidence that this is not always the case and that rapid and reproducible gastric emptying of small particles does not always occur when they are administered. There is strong evidence that food can delay the gastric emptying of multi-particulate systems. Some of the misconception for gastric emptying performance of multi-particulate system is shown to be related to the limitation of the study design and limitation of the way the data is processed. Nevertheless, there is clear evidence that multi-particulate systems can provide effective oral controlled release dosage forms. There is still some way to go with experimental techniques which would allow a definitive answer to the issue of how the variability of the gastric emptying of multi-particulate systems of less than 2.0mm arises.
Newton
J Michael
JM
Department of Mechanical Engineering, University College London, Torrington Place, London WC1 7JE, UK. m_newton@meng.ucl.ac.uk
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D004435:Eating; D005746:Gastric Emptying; D006801:Humans; D007700:Kinetics; D010316:Particle Size; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012107:Research Design; D013270:Stomach / Q000000981:diagnostic imaging / Q000502:physiology*
D003692:Delayed-Action Preparations; D004304:Dosage Forms