title: Threshold Average Precision (TAP-k): a measure of retrieval designed for bioinformatics.
abstract: BACKGROUND
  Since database retrieval is a fundamental operation, the measurement of retrieval efficacy is critical to progress in bioinformatics. This article points out some issues with current methods of measuring retrieval efficacy and suggests some improvements. In particular, many studies have used the pooled receiver operating characteristic for n irrelevant records (ROC(n)) score, the area under the ROC curve (AUC) of a 'pooled' ROC curve, truncated at n irrelevant records. Unfortunately, the pooled ROC(n) score does not faithfully reflect actual usage of retrieval algorithms. Additionally, a pooled ROC(n) score can be very sensitive to retrieval results from as little as a single query.
  
  
  METHODS
  To replace the pooled ROC(n) score, we propose the Threshold Average Precision (TAP-k), a measure closely related to the well-known average precision in information retrieval, but reflecting the usage of E-values in bioinformatics. Furthermore, in addition to conditions previously given in the literature, we introduce three new criteria that an ideal measure of retrieval efficacy should satisfy.
  
  
  RESULTS
  PSI-BLAST, GLOBAL, HMMER and RPS-BLAST provided examples of using the TAP-k and pooled ROC(n) scores to evaluate sequence retrieval algorithms. In particular, compelling examples using real data highlight the drawbacks of the pooled ROC(n) score, showing that it can produce evaluations skewing far from intuitive expectations. In contrast, the TAP-k satisfies most of the criteria desired in an ideal measure of retrieval efficacy.
  
  
  METHODS
  The TAP-k web server and downloadable Perl script are freely available at http://www.ncbi.nlm.nih.gov/CBBresearch/Spouge/html.ncbi/tap/
authors.affiliation: National Center for Biotechnology Information, Bethesda, MD 20894, USA.
authors.forename: Hyrum D
authors.initials: HD
authors.lastname: Carroll
authors.forename: Maricel G
authors.initials: MG
authors.lastname: Kann
authors.forename: Sergey L
authors.initials: SL
authors.lastname: Sheetlin
authors.forename: John L
authors.initials: JL
authors.lastname: Spouge
mesh_terms: D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D012372:ROC Curve; D012984:Software