COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.
The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
Shashi
Vandana
V
Duke University Medical Center, Division of Medical Genetics, Department of Pediatrics, Durham, North Carolina 27710, USA. vandana.shashi@duke.edu
Howard
Timothy D
TD
Keshavan
Matcheri S
MS
Kaczorowski
Jessica
J
Berry
Margaret N
MN
Schoch
Kelly
K
Spence
Edward J
EJ
Kwapil
Thomas R
TR
D000293:Adolescent; D001007:Anxiety / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D003072:Cognition Disorders / Q000235:genetics*; D004062:DiGeorge Syndrome / Q000235:genetics*; D056344:Executive Function / Q000502:physiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D014633:Valine / Q000235:genetics
D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine