Immunoglobulin A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in a patient with atypical bullous pemphigoid.
Bullous pemphigoid is an autoimmune subepidermal blistering disease associated with autoantibodies against BP180 and BP230. We report herein a rare case of bullous pemphigoid with newly formed annular erythematous lesions when bullous skin lesions were in remission. Various immunological studies revealed immunoglobulin (Ig)A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in addition to IgG antibodies against BP180 and BP230. These clinical and immunological changes in a patient are a rare event, suggesting an epitope-spreading phenomenon.
Yamaki
Fumi
F
Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. fumitomishima@yahoo.co.jp
Mayuzumi
Nobuyasu
N
Ikeda
Shigaku
S
Hashimoto
Takashi
T
D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology; D003622:Dapsone / Q000627:therapeutic use; D051183:Desmoglein 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D010391:Pemphigoid, Bullous / Q000188:drug therapy / Q000276:immunology*; D051179:Plakins / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D011498:Protein Precursors / Q000276:immunology*
D001323:Autoantibodies; D051183:Desmoglein 1; D007070:Immunoglobulin A; D008565:Membrane Proteins; C491674:PPL protein, human; D051179:Plakins; D011498:Protein Precursors; C100754:envoplakin; D003622:Dapsone; D011239:Prednisolone