Solid-phase synthesis of PEGylated lipopeptides using click chemistry.
A versatile methodology for efficient synthesis of PEGylated lipopeptides via CuAAC "Click" conjugation between alkyne-bearing solid-supported lipopeptides and azido-functionalized PEGs is described. This new and very robust method offers a unique platform for synthesizing PEGylated lipopeptides with a high level of complexity. These molecules, obtained in a single purification step, are ideally suited for functionalization of solid-supported lipid bilayers and liposomal drug delivery systems and are particularly valuable in enzyme activation strategies.
Jølck
Rasmus I
RI
Technical University of Denmark, DTU Nanotech, Department of Micro- and Nanotechnology, Frederiksborgvej 399, 4000 Roskilde, Denmark.
Berg
Rolf H
RH
Andresen
Thomas L
TL
D000595:Amino Acid Sequence; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D055666:Lipopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry
D055666:Lipopeptides; D011092:Polyethylene Glycols