Altered fractionation in radiotherapy: from radiobiological rationale to therapeutic gain.
The implementation of altered fractionation schedules in clinical practice came as a need to improve loco-regional control and survival in those cancer patient groups which did not respond satisfactorily to conventionally fractionated radiotherapy. The current review aims to present the radiobiological rationale behind various non-conventional treatment schedules including the encountered challenges, through a compilation of clinical studies/trials and their contribution towards therapeutic gain.
Marcu
Loredana G
LG
University of Oradea, Faculty of Science, Romania. loredana@marcunet.com
D001943:Breast Neoplasms / Q000532:radiotherapy; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005544:Forecasting; D005909:Glioblastoma / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000517:prevention & control*; D018787:Radiation Oncology / Q000592:standards / Q000639:trends; D011836:Radiation Tolerance; D011853:Radiobiology; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D018570:Risk Assessment; D016896:Treatment Outcome