title: Ranking initial environmental and human health risk resulting from environmentally relevant nanomaterials.
abstract: As nanomaterials find increased application in commercial and industrial products and processes so too the potential for release of these novel materials into the environment increases. The characteristics of these materials also may result in novel toxicological actions related to their nanoscale, which will have implications on their ecotoxicological and toxicological limits of exposure and eventual regulation. A framework for nanomaterial risk assessment on regulatory, ecotoxicological and toxicological bases developed from recent exposure and toxicity studies is presented. The release of nanoscale TiO(2), Ag and CeO(2) to the atmosphere and surface waters is assessed against provisional toxicological bench mark doses (BMDs) and critical effect doses (CEDs) developed from best available data. Predicted levels of nanomaterial release to surface waters and the atmosphere resulted in regulatory risk rankings of moderate concern based on worst case provisional regulatory limits. Inhalation and ingestion risk rankings were of very low concern based on the provisional inhalation and ingestion toxicity BMDLs and CEDLs determined for the nanomaterials in question. More toxicological data is needed on nanoscale CeO(2) inhalation to develop a true dose response as in vitro cytotoxicity studies yielded an inhalation risk ranking of lower concern. The moderate to high ecotoxicological risk rankings posed by the release of nanoscale TiO(2) and Ag to surface waters highlights the need for guidance and restriction on the usage and disposal of commercial products containing nanomaterial. The risk rankings presented in this assessment give a first indication of the relative risks posed by the usage and release of these materials into the environment and indicate what materials require further investigation into their nano-specific toxicological actions. As more nano-relevant toxicity studies are published, end-points and risk levels related to nano-specific toxicity actions may be determined and the provisional BMDLs developed as part of this framework refined, resulting in more confident risk rankings.
authors.affiliation: Biosystems Engineering, UCD School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, Dublin, Ireland.
authors.forename: Niall
authors.initials: N
authors.lastname: O'Brien
authors.forename: Enda
authors.initials: E
authors.lastname: Cummins
mesh_terms: D002563:Cerium / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D006292:Health Priorities; D006801:Humans; D053768:Metal Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D018570:Risk Assessment; D018030:Silver Compounds / Q000633:toxicity*; D013499:Surface Properties; D014025:Titanium / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D018030:Silver Compounds; C009495:titanium dioxide; D002563:Cerium; C030583:ceric oxide; D014025:Titanium