title: Takotsubo cardiomyopathy induced by dobutamine infusion during hypertensive therapy for symptomatic vasospasm after subarachnoid hemorrhage -case report-.
abstract: A 65-year-old female with subarachnoid hemorrhage (SAH) developed takotsubo cardiomyopathy induced by dobutamine infusion for vasospasm 9 days after onset of SAH. She underwent neck clipping of the ruptured cerebral aneurysm on day 1. Course after surgery was uneventful, but she developed motor aphasia on day 9. Hypertensive therapy was carried out under the diagnosis of symptomatic vasospasm. Half an hour after initiation of dobutamine infusion at 6 microg/kg/min, sudden symptoms of takotsubo cardiomyopathy developed. Fortunately, her symptoms recovered in a few days with supportive therapy without any consequences. Takotsubo cardiomyopathy is one pattern of cardiac dysfunction occasionally encountered after SAH. Possible mechanisms of this disorder include epicardial catecholamine cardiotoxicity. Therefore, generally, cardiac function is worst at the early stage of SAH, when sympathetic activity is highest, and recovers thereafter. Dobutamine infusion seems to have triggered the takotsubo cardiomyopathy in the present patient even 9 days after onset of SAH. Inotropic agents including dobutamine are often used during the course of SAH, and since takotsubo cardiomyopathy can occur in patients with SAH, this complication must be considered.
authors.affiliation: Department of Neurosurgery, Saitama Red Cross Hospital, Chuo-ku, Saitama, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Saito
authors.forename: Toshie
authors.initials: T
authors.lastname: Takahashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Noshita
authors.forename: Ayumi
authors.initials: A
authors.lastname: Narisawa
authors.forename: Ken
authors.initials: K
authors.lastname: Negi
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Takei
authors.forename: Uichi
authors.initials: U
authors.lastname: Kaneko
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000601:surgery; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004280:Dobutamine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007261:Infusions, Intra-Arterial; D002532:Intracranial Aneurysm / Q000601:surgery; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery; D054549:Takotsubo Cardiomyopathy / Q000150:complications*; D020301:Vasospasm, Intracranial / Q000150:complications / Q000188:drug therapy*
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine