title: [A rare interstitital lung disease in two smokers].
abstract: Pulmonary Langerhans-cell histiocytosis should be suspected in patients with nodular or cystic changes in the upper pulmonary lobes. Patients with Langerhans-cell histiocytosis usually have a history of smoking; lack of nicotine exposure or an age over 60 years makes the diagnosis unlikely. The diagnostic work-up should include a high-resolution CT of the chest as well as a bronchoalveolar lavage, bronchoscopic and/or surgical lung biopsy. Smoking cessation is the essential part of the treatment.
authors.affiliation: Departement für Innere Medizin, Kantonsspital Graubünden, Chur.
authors.forename: D
authors.initials: D
authors.lastname: Mayer
authors.forename: G
authors.initials: G
authors.lastname: Gadient
authors.forename: M
authors.initials: M
authors.lastname: Kuhn
mesh_terms: D000328:Adult; D001706:Biopsy; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed