title: Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study.
abstract: Posttraumatic stress disorder (PTSD) accounts for a substantial proportion of casualties among surviving soldiers of the Iraq and Afghanistan wars. Currently, the assessment of PTSD is based exclusively on symptoms, making it difficult to obtain an accurate diagnosis. This study aimed to find potential imaging markers for PTSD using structural, perfusion, and diffusion magnetic resonance imaging (MRI) together. Seventeen male veterans with PTSD (45 ± 14 years old) and 15 age-matched male veterans without PTSD had measurements of regional cerebral blood flow (rCBF) using arterial spin labeling (ASL) perfusion MRI. A slightly larger group had also measurements of white matter integrity using diffusion tensor imaging (DTI) with computations of regional fractional anisotropy (FA). The same subjects also had structural MRI of the hippocampal subfields as reported recently (W. Zhen et al. Arch Gen Psych 2010;67(3):296-303). On ASL-MRI, subjects with PTSD had increased rCBF in primarily right parietal and superior temporal cortices. On DTI, subjects with PTSD had FA reduction in white matter regions of the prefrontal lobe, including areas near the anterior cingulate cortex and prefrontal cortex as well as in the posterior angular gyrus. In conclusion, PTSD is associated with a systematic pattern of physiological and structural abnormalities in predominantly frontal lobe and limbic brain regions. Structural, perfusion, and diffusion MRI together may provide a signature for a PTSD marker.
authors.affiliation: Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA. norbert.schuff@ucsf.edu
authors.forename: Norbert
authors.initials: N
authors.lastname: Schuff
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wang
authors.initials: W
authors.lastname: Zhan
authors.forename: Maryann
authors.initials: M
authors.lastname: Lenoci
authors.forename: Christopher
authors.initials: C
authors.lastname: Ching
authors.forename: Lauren
authors.initials: L
authors.lastname: Boreta
authors.forename: Susanne G
authors.initials: SG
authors.lastname: Mueller
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Charles R
authors.initials: CR
authors.lastname: Marmar
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Neylan
mesh_terms: D016880:Anisotropy; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003130:Combat Disorders / Q000473:pathology / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged