[Effect of post-treatment with dry extract from vicia truncatula on NADPH-GSH dependent system of rat liver during chronic alcohol intoxication].
Experiments on white female rats showed that chronic ethanol consumption leads to activation of the NADPH - GSH dependent system of the liver, which provides protection against ethanol-induced oxidative stress. Post-treatment administration of dry extract from Vicia truncatula Fish ex Bieb. (300 mg/kg body weight) on the background of 40% ethanol increased this adaptive reaction without depletion in the system, in contrast to what was observed in rats treated with carsil. These results suggest a significant hepatoprotective effect of the dry extract during the chronic alcohol-induced injury of the liver.
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D000437:Alcoholism / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D031306:Vicia / Q000737:chemistry*
D010936:Plant Extracts; D009249:NADP; D005978:Glutathione