title: Treatment of auricular hematoma by OK-432.
abstract: OBJECTIVE
  Intralesional injection therapy with OK-432 was developed as a therapy for operatively difficult lymphangioma (cystic hygroma) and is currently becoming a first-choice treatment for this disease. The aim of this article was to evaluate the outcome and complications of the treatment of patients with auricular hematoma by OK-432 therapy.
  
  
  METHODS
  Case series with planned data collection.
  
  
  METHODS
  Yamagata University School of Medicine.
  
  
  METHODS
  We tried this therapy in 21 patients with auricular hematoma between January 2001 and February 2009. We injected OK-432 solution into the lesion with a 27-gauge needle to prevent the leak of the agent out of the hematoma. We performed this treatment on an outpatient basis without hospitalization.
  
  
  RESULTS
  Disappearance or marked reduction of the lesion were observed in all patients who had this therapy, and local scarring and deformity of the auricle did not occur in any patients. As for side effects, local pain at the injection site and fever (37 degrees C-38 degrees C) were observed in a few of the patients who had this therapy, but such problems resolved within a few days.
  
  
  CONCLUSIONS
  These results may allow us to speculate that intralesional injection therapy with OK-432 is simple, easy, safe, and effective and can be used as a substitute for surgery in the treatment of auricular hematoma.
authors.affiliation: Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Kubota
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ohta
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fukase
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kon
authors.forename: Masaru
authors.initials: M
authors.lastname: Aoyagi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D054644:Ear Auricle; D004427:Ear Diseases / Q000188:drug therapy*; D005260:Female; D006406:Hematoma / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil