Occupational asthma: risk factors, diagnosis and preventive measures.
In adulthood, new or recurrent asthma is caused by work in approximately 10% of cases. The term occupational asthma is reserved for those cases arising from respiratory hypersensitivity to a specific workplace agent; in others (work-exacerbated asthma) the mechanism is of nonspecific airway irritation on a background of bronchial hyper-reactivity. Some 300 workplace agents are capable of inducing asthma de novo; fortunately, most cases are attributed to a much smaller number to which exposure occurs in a few high-risk occupations. Exposure level is the most important remediable risk factor; the factors governing individual susceptibility are poorly understood. Diagnosis is generally straightforward. Management is rarely pharmacologic and often difficult since the diagnosis incurs important employment and other social consequences.
Cullinan
Paul
P
Department of Occupational and Environmental Medicine, Imperial College, London, UK. p.cullinan@imperial.ac.uk