title: Signal integration through blending, bolstering and bifurcating of intracellular information.
abstract: A cell's response to its environment is often determined by signaling through the actions of enzyme cascades. The ability to organize these enzymes into multiprotein complexes allows for a high degree of fidelity, efficiency and spatial precision in signaling responses.
authors.affiliation: Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, School of Medicine, Seattle, Washington, USA.
authors.forename: Catherine T
authors.initials: CT
authors.lastname: Pawson
authors.forename: John D
authors.initials: JD
authors.lastname: Scott
mesh_terms: D000818:Animals; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004798:Enzymes; D047908:Intracellular Signaling Peptides and Proteins; D009097:Multienzyme Complexes