Iodine-promoted domino reaction leading to N-substituted 2-aminoquinoline-3-carbonitriles under microwave irradiation.
A new iodine-promoted domino reaction of 2-aminochromene-3-carbonitriles with various isocyanates is described, and a set of polyfunctionalized N-substituted 2-aminoquinoline-3-carbonitriles with high regioselectivity were successfully synthesized under microwave heating. In this reaction, the ring-opening/recyclization process occurs unexpectedly at the ring of 4H-pyran with different isocyanates.
Jiang
Bo
B
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, PR China.
Li
Chao
C
Tu
Shu-Jiang
SJ
Shi
Feng
F
D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D009570:Nitriles; D011804:Quinolines; D007455:Iodine