Extravasation of chemotherapy.
Extravasation of chemotherapy is a feared complication of anticancer therapy. The accidental leakage of cytostatic agents into the perivascular tissues may have devastating short-term and long-term consequences for patients. In recent years, the increased focus on chemotherapy extravasation has led to the development of international guidelines that have proven useful tools in daily clinical practice. Moreover, the tissue destruction in one of the most dreaded types of extravasation (ie, anthracycline extravasation) now can effectively be prevented with a specific antidote, dexrazoxane.
Langer
Seppo W
SW
Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark. seppo@rh.dk
D018943:Anthracyclines / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000517:prevention & control*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011929:Razoxane / Q000627:therapeutic use*; D016896:Treatment Outcome
D018943:Anthracyclines; D004364:Pharmaceutical Preparations; D011929:Razoxane