Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis.
Recently, evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies. Based on structure and function, EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33. We genotyped three single-nucleotide polymorphisms (SNPs: rs9520087, rs11069646, and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls). Significant association between an allele of marker rs9520087 and schizophrenia was found. Furthermore, since no LD was observed in the three SNPs linkage disequilibrium estimation, all three SNPs were used in multiple SNPs haplotype analysis, and a strongly significant difference was found for the common haplotype TTC. Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population, and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia.
Zhang
Rui
R
Department of Genetics and Molecular Biology, and First Affliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, PR China.
Zhong
Nan-Nan
NN
Liu
Xiao-Gang
XG
Yan
Han
H
Qiu
Chuan
C
Han
Yan
Y
Wang
Wei
W
Hou
Wei-Kun
WK
Liu
Yue
Y
Gao
Cheng-Ge
CG
Guo
Ting-Wei
TW
Lu
She-Min
SM
Deng
Hong-Wen
HW
Ma
Jie
J
D000368:Aged; D044466:Asian People / Q000208:ethnology; D016009:Chi-Square Distribution; D036388:Ephrin-B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors
D036388:Ephrin-B2