Compounds from Acorus tatarinowii: determination of absolute configuration by quantum computations and cAMP regulation activity.
A new cadinane-type sesquiterpenoid, tatarinowin A (1), two phenylpropanoids, tatarinoids A (2) and B (3), and a trinorlignan, tatarinoid C (4), along with 15 known compounds including two pairs of mixtures were isolated from the rhizome of Acorus tatarinowii. The absolute configurations of 1-4 were established by computation of specific rotation values. The isolated compounds were evaluated for their cAMP regulatory activity by the AlphaScreen assay.
Tong
Xiao-Gang
XG
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Wu
Gui-Sheng
GS
Huang
Cheng-Gang
CG
Lu
Qing
Q
Wang
Yue-Hu
YH
Long
Chun-Lin
CL
Luo
Huai-Rong
HR
Zhu
Hua-Jie
HJ
Cheng
Yong-Xian
YX
D029023:Acorus / Q000737:chemistry*; D000242:Cyclic AMP / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D017705:Lignans; D010666:Phenylpropionates; D012717:Sesquiterpenes; D000242:Cyclic AMP