title: A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.
abstract: Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne 'click' reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.
authors.affiliation: The School of Chemistry, University of Nottingham, University Park, Nottingham, UK NG7 2RD. john.moses@nottingham.ac.uk
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
authors.forename: Dougal J
authors.initials: DJ
authors.lastname: Ritson
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Zhang
authors.forename: Caterina Maria
authors.initials: CM
authors.lastname: Lombardo
authors.forename: Shozeb
authors.initials: S
authors.lastname: Haider
authors.forename: Neil
authors.initials: N
authors.lastname: Oldham
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009691:Nucleic Acid Denaturation; D021241:Spectrometry, Mass, Electrospray Ionization; D044366:Transition Temperature; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D008024:Ligands; D014230:Triazoles; D003300:Copper; D004247:DNA