Anchoring local translation in neurons.
In probing how protein synthesis in neurons is coupled to extracellular stimuli, Tcherkezian et al. (2010) discover that the receptor protein DCC anchors components of the translation machinery at the plasma membrane. Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis.
Martin
Kelsey C
KC
Department of Biological Chemistry, University of California, Los Angeles, BSRB 390B, 615 Charles E Young Drive South, Los Angeles, CA 90095-1737, USA. kcmartin@mednet.ucla.edu