Remifentanil in neonatal intensive care and anaesthesia practice.
Remifentanil is a relatively new ultrashort action synthetic opioid. Studies on the use of remifentanil in neonatology have emerged demonstrating its effectiveness and safety in neonates. The present study describes the use of remifentanil in both full-term and premature newborns, highlighting the theoretical benefits for this population in terms of both neonatal intensive care and anaesthesia. A Medline search was undertaken of all reviews and reports about the use of remifentanil in neonates published between 1996 and 2009 using MeSH search terms 'remifentanil', 'analgesia', 'anaesthesia', 'newborn' and 'neonate'. The review points that remifentanil has been used with advantages in newborns including preterm neonates and even for foetal anaesthesia. It proved to be a good option to attenuate the hemodynamic/endocrine markers of stress related to surgery. Owing to its unique pharmacokinetic profile, shorter extubation times can be achieved what makes the drug also a good option for short duration invasive procedures in NICUs (InSurE). A concern on its use is that the hemodynamic response (hypotension) may become significant when the drug is associated to other drugs like sevoflurane.


CONCLUSIONS
Remifentanil seems to be an effective and safely used opioid for neonatal intensive care and anaesthesia practice.
Penido
Márcia Gomes
MG
Department of Neonatology, Julia Kubitschek Hospital, Belo Horizonte, Brazil.
Garra
Rossella
R
Sammartino
Maria
M
Pereira e Silva
Yerkes
Y
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal; D007442:Intubation, Intratracheal; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077208:Remifentanil
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil