title: MAGIA, a web-based tool for miRNA and Genes Integrated Analysis.
abstract: MAGIA (miRNA and genes integrated analysis) is a novel web tool for the integrative analysis of target predictions, miRNA and gene expression data. MAGIA is divided into two parts: the query section allows the user to retrieve and browse updated miRNA target predictions computed with a number of different algorithms (PITA, miRanda and Target Scan) and Boolean combinations thereof. The analysis section comprises a multistep procedure for (i) direct integration through different functional measures (parametric and non-parametric correlation indexes, a variational Bayesian model, mutual information and a meta-analysis approach based on P-value combination) of mRNA and miRNA expression data, (ii) construction of bipartite regulatory network of the best miRNA and mRNA putative interactions and (iii) retrieval of information available in several public databases of genes, miRNAs and diseases and via scientific literature text-mining. MAGIA is freely available for Academic users at http://gencomp.bio.unipd.it/magia.
authors.affiliation: Department of Biology, University of Padua, via U. Bassi 58/B, 35121 Padova, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sales
authors.forename: Alessandro
authors.initials: A
authors.lastname: Coppe
authors.forename: Andrea
authors.initials: A
authors.lastname: Bisognin
authors.forename: Marta
authors.initials: M
authors.lastname: Biasiolo
authors.forename: Stefania
authors.initials: S
authors.lastname: Bortoluzzi
authors.forename: Chiara
authors.initials: C
authors.lastname: Romualdi
mesh_terms: D015870:Gene Expression; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D012984:Software
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger