Antimycotic effectiveness against dermatophytes: comparison of two in vitro tests.
Seven antimycotic drugs (econazole, enilconazole, fluconazole, griseofulvin, itraconazole, ketoconazole, and miconazole) were tested against 36 dermatophyte strains (19 M. canis, 7 T. mentagrophytes, 5 M. gypseum, 2 M. cookei, 1 T. rubrum, 1 T. ajelloi, and 1 T. terrestre) isolated from animals, humans, and the environment. Two in vitro methods were compared: a micro-dilution test based on the CLSI M38-A method, and a disk-diffusion test. Fluconazole was not effective in vitro against the dermatophytes. Econazole and enilconazole were the most effective. Thirteen strains were griseofulvin-resistant. The correlation between the two methods was statistically significant for enilconazole, griseofulvin, itraconazole, and miconazole.
Galuppi
Roberta
R
Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Alma Mater Studiorum-Università di Bologna, Bologna, Italy. roberta.galuppi@unibo.it
Gambarara
Alessandra
A
Bonoli
Cristina
C
Ostanello
Fabio
F
Tampieri
Maria Paola
MP
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods*
D000935:Antifungal Agents