title: [Genetics risk factors in chronic obstructive pulmonary disease].
abstract: Chronic obstructive pulmonary disease (COPD) is not fully recognized process regarding many risk factors genetics and environmental. Etiology of COPD is not fully understood. There is evidence of a hereditary component in COPD. Patients with hereditary alpha1-antitrypsin deficiency are at risk of developing COPD. A number of genetic association studies have been performed to find susceptibility genes of COPD. Many of genes play an important role in development of COPD. This review examines the impact of alpha1-antitrypsin, matrix metalloproteinases, tumour necrosis factor gene a, microsomal epoxide hydrolase, transforming growth factor b-1, Vitamin D-binding protein and CFTR on COPD extension.
authors.affiliation: Wydział Lekarski Uniwersytetu Medycznego w todzi, student; 2Pracownia Biologii Molekularnej, Zaklad Patomorfologii Klinicznej, Instytut Centrum Zdrowia Matki Polki, kierownik: prof dr hab. med. A. Kulig.
authors.forename: M
authors.initials: M
authors.lastname: Makowska
authors.forename: H
authors.initials: H
authors.lastname: Romanowicz
authors.forename: A
authors.initials: A
authors.lastname: Kulig
authors.forename: B
authors.initials: B
authors.lastname: Smolarz
mesh_terms: D004851:Epoxide Hydrolases / Q000378:metabolism; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism; D014809:Vitamin D-Binding Protein / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D019896:alpha 1-Antitrypsin Deficiency / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D014809:Vitamin D-Binding Protein; D000515:alpha 1-Antitrypsin; D004851:Epoxide Hydrolases; D020782:Matrix Metalloproteinases