Oxidative stress in benign prostatic hyperplasia and prostate cancer.
OBJECTIVE
The aim was to verify whether oxidative stress could represent a common key factor of benign prostatic hyperplasia (BPH) and prostate cancer (PCa).


METHODS
15 patients affected by BPH, 15 with PCa and 15 controls were enrolled. Blood samples were withdrawn systemically and locally during radical retropubic prostatectomy in patients with PCa and during transvesical retropubic adenomectomy in patients diagnosed with BPH. Plasma oxidized low-density lipoprotein, peroxides, and total equivalent antioxidant capacity (TEAC) including plasma superoxide dismutase (SOD) determination were analyzed as oxidative markers.


RESULTS
With respect to the control group, high plasma peroxides and decreased TEAC levels were measured in patients affected by both PCa and BPH. Plasma peroxides were significantly higher in patients with PCa with respect to BPH. A positive correlation was found between peroxides and TEAC values in samples withdrawn locally in patients affected by PCa. An inverse correlation between peroxides and TEAC was observed in patients with BPH. No statistically significant modifications were observed as concerns SOD activity and LDL oxidability.


CONCLUSIONS
Our findings confirm a significant unbalance of redox status in patients affected by BPH and PCa, and suggest a potential involvement of oxidative stress as a determinant in the pathogenesis of these diseases.
Pace
Gianna
G
Department of Health Sciences, University of L'Aquila, L'Aquila, Italy. giannapace @ gmail.com
Di Massimo
Caterina
C
De Amicis
Daniela
D
Corbacelli
Carlo
C
Di Renzo
Laura
L
Vicentini
Carlo
C
Miano
Lucio
L
Tozzi Ciancarelli
Maria Giuliana
MG
D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002138:Calibration; D015331:Cohort Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010545:Peroxides / Q000737:chemistry; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014572:Urology / Q000379:methods*
D000975:Antioxidants; D008077:Lipoproteins, LDL; D010545:Peroxides; C099252:oxidized low density lipoprotein; D013482:Superoxide Dismutase