The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial.
OBJECTIVE
To test recolonization of periodontal lesions after full-mouth scaling and root planing (FM-SRP) or multiple session-SRP (MS-SRP) in a randomized clinical trial and whether FM-SRP and MS-SRP result in different clinical outcomes.


METHODS
Thirty-nine subjects were randomly assigned to FM-SRP or MS-SRP groups. At baseline and after 3 months, probing pocket depth (PPD), plaque index (PlI) and bleeding on probing (BoP) were recorded. At baseline, immediately after treatment, after 1, 2, 7, 14 and 90 days, paper point samples from a single site from the maxillary right quadrant were collected for microbiological analysis of five putative pathogens by polymerase chain reaction.


RESULTS
FM-SRP and MS-SRP resulted in significant reductions in PPD, BoP and PlI and the overall detection frequencies of the five species after 3 months without significant differences between treatments. Compared with MS-SRP, FM-SRP resulted in less recolonization of the five species, significantly for Treponema denticola, in the tested sites.


CONCLUSIONS
FM-SRP and MS-SRP result in overall clinically and microbiologically comparable outcomes where recolonization of periodontal lesions may be better prevented by FM-SRP.
Zijnge
Vincent
V
Department of Periodontology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Meijer
Henriette F
HF
Lie
Mady-Ann
MA
Tromp
Jan A H
JA
Degener
John E
JE
Harmsen
Hermie J M
HJ
Abbas
Frank
F
D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000254:growth & development; D001419:Bacteria / Q000145:classification / Q000254:growth & development*; D001439:Bacteroides / Q000254:growth & development; D055113:Chronic Periodontitis / Q000382:microbiology* / Q000628:therapy; D002985:Clinical Protocols; D015169:Colony Count, Microbial; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000382:microbiology / Q000628:therapy; D016967:Fusobacterium nucleatum / Q000254:growth & development; D005884:Gingival Hemorrhage / Q000382:microbiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000254:growth & development; D016745:Root Planing / Q000379:methods*; D013357:Subgingival Curettage / Q000379:methods; D016896:Treatment Outcome; D048373:Treponema denticola / Q000254:growth & development