Structure-activity analysis of the Pseudomonas quinolone signal molecule.
We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.
Hodgkinson
James
J
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
Bowden
Steven D
SD
Galloway
Warren R J D
WR
Spring
David R
DR
Welch
Martin
M
D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D015394:Molecular Structure; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism; D011549:Pseudomonas / Q000187:drug effects* / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C407944:2-heptyl-3-hydroxy-4-quinolone; D009842:Oligopeptides; D015363:Quinolones; C042453:pyoverdin