title: [Effects of CRF receptor antagonist on rem sleep in neonatal rat].
abstract: OBJECTIVE
  To observe the role of NB127914, a CRF R1 receptor antagonist, in the regulation of neonatal sleep/wake cycle.
  
  
  METHODS
  Rat pups were surgically implanted with electrodes at postnatal day(PN) 13. At PN 14, 6 hours polysomnographic recording data were continuously collected before and after administration of various doses of NBI 27914, atropine and the same amount of saline.
  
  
  RESULTS
  Compared with baseline, rapid eye movement (REM) sleep was significantly reduced and was replaced primarily by non-REM (NREM) sleep in all groups treated with NBI, but not with dimethyl sulfoxide/saline. Atropine suppressed REM sleep significantly and increased wakefulness simultaneously.
  
  
  CONCLUSIONS
  Blockage of corticotropin-releasing factor (CRF) R1 receptors deprives neonatal rat REM sleep.
authors.affiliation: Department of Physiology, Medical School in Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Xue-dong
authors.initials: XD
authors.lastname: Liu
authors.forename: Hong-kun
authors.initials: HK
authors.lastname: Fan
authors.forename: Gui-hong
authors.initials: GH
authors.lastname: Zhang
authors.forename: Shu-chun
authors.initials: SC
authors.lastname: Wang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ping-fu
authors.initials: PF
authors.lastname: Feng
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D017286:Polysomnography; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology; D000099052:CRF Receptor, Type 1
chemical_list: C471210:2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; D000814:Aniline Compounds; D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1