title: Long-term changes in gut hormones, appetite and food intake 1 year after subtotal gastrectomy with normal body weight.
abstract: OBJECTIVE
  No prospective study on the long-term effects of gastric resection on gastrointestinal hormonal changes in patients with normal body weight has been reported. The aim of this study was to evaluate the 1-year effect of subtotal gastrectomy on ghrelin and peptide YY (PYY)(3-36) levels.
  
  
  METHODS
  Eighteen patients with early gastric cancer underwent subtotal gastrectomy with Billroth I reconstruction. We assessed appetite, food intake, body composition, and ghrelin and PYY(3-36) levels preoperatively and 1 year after surgery.
  
  
  RESULTS
  There were no significant difference in the preoperative daily food intake and 1 year after subtotal gastrectomy. Weight loss occurred in all study subjects; 11.7% (n=2), 55.5% (n=10) and 33.3% (n=6) of the patients lost <5%, 5-10% and >10% of their preoperative body weight, respectively. Body mass index, waist circumference and body fat significantly decreased 1 year after subtotal gastrectomy. There were no significant differences in the appetite visual analogue scale preoperatively and 1 year after subtotal gastrectomy. The plasma ghrelin concentration decreased significantly (P=0.006), whereas PYY(3-36) did not show a significant change 1 year after subtotal gastrectomy.
  
  
  CONCLUSIONS
  Ghrelin levels and body fat decreased significantly, whereas PYY(3-36) levels as well as appetite and food intake did not change significantly 1 year after subtotal gastrectomy with normal body weight. These findings suggest that decreased ghrelin might contribute directly to reduced body fat.
authors.affiliation: Department of Surgery, Pusan National University Hospital, Busan, South Korea.
authors.forename: T Y
authors.initials: TY
authors.lastname: Jeon
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: H H
authors.initials: HH
authors.lastname: Kim
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: J G
authors.initials: JG
authors.lastname: Lee
authors.forename: D W
authors.initials: DW
authors.lastname: Jeong
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D001066:Appetite; D015992:Body Mass Index; D002149:Energy Intake; D005260:Female; D005743:Gastrectomy; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D056865:Ideal Body Weight; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D019894:Peptide YY / Q000097:blood*; D016012:Poisson Distribution; D011183:Postoperative Complications / Q000097:blood*; D011446:Prospective Studies; D013995:Time; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D054439:Ghrelin; D019894:Peptide YY