Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by 'click' chemistry.
Thirteen new 1,2,3-triazoles (5a-e, 15a-d, 17a-b, 19, and 21) were synthesized by 'click' reaction of sugar-derived azides with commercially available acetylenes. The synthesized triazoles were tested in vitro for their biological activity, and compound 5b displayed both antibacterial and antifungal activities at an MIC value of 12.5 microg/mL, while compounds 15b and 19 showed antibacterial activity at an MIC value of 25 microg/mL.
Vijaya Raghava Reddy
L
L
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
Venkat Reddy
P
P
Mishra
Nripendra N
NN
Shukla
Praveen K
PK
Yadav
Garima
G
Srivastava
Ranjana
R
Shaw
Arun K
AK
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D014230:Triazoles; C018674:tetrahydrofuran