Antibodies against cyclic citrullinated peptide in Japanese psoriatic arthritis patients.
Anti-cyclic citrullinated peptide antibodies (anti-CCP) are highly considered to indicate disease severity and be predictive markers in rheumatoid arthritis (RA). RA patients who are positive for anti-CCP tend to progress more frequently to joint deformity and functionally deteriorate more than negative patients. A study concerning the presence of anti-CCP in Japanese patients with psoriatic arthritis (PsA) has been published. Our aim was to clarify that anti-CCP could be a potentially useful marker in PsA patients. We herein describe a PsA patient with presence of anti-CCP. We examined anti-CCP in 15 patients with PsA, and compared with 18 controls who had other types of psoriasis. Three PsA patients were positive for anti-CCP, but no controls showed positive. The anti-CCP-positive patients had higher counts of radiographic erosion, higher prevalence rates of polyarticular disease, use of disease-modifying anti-rheumatic drugs, and the human leukocyte antigen DRB1*04 shared epitope than negative patients. Our study demonstrated that anti-CCP was potentially both predictive and a severity marker of joint involvement in PsA, the same as in RA.
Maejima
Hideki
H
Department of Dermatology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan. hm4765@yahoo.co.jp
Aki
Ryouichi
R
Watarai
Akira
A
Shirai
Kyoumi
K
Hamada
Yuko
Y
Katsuoka
Kensei
K
D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000276:immunology; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D000939:Epitopes / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D011859:Radiography; D012720:Severity of Illness Index
D018501:Antirheumatic Agents; D001323:Autoantibodies; D015415:Biomarkers; D000939:Epitopes; D006680:HLA Antigens; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide