New perspectives in MicroRNA regulation of innate immunity.
The fine-tuning of the innate immune response by microRNAs (miRNAs) is a concept now supported by a rapidly growing body of evidence. Target prediction analyses indicate that up to a half of innate immune genes could be under the direct regulation of miRNAs. However, the extent to which miRNAs regulate innate immunity remains poorly defined and is currently limited to a handful of target genes. This review highlights several important parameters of miRNA regulation, mostly neglected in the field, which underpin the relevance of miRNAs in the regulation of innate immunity.
Gantier
Michael P
MP
Centre for Cancer Research, Monash Institute of Medical Research, Monash University , Clayton, Victoria, Australia. michael.gantier@med.monash.edu.au
D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology; D035683:MicroRNAs; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy
D007375:Interleukin-1; D035683:MicroRNAs; D051193:Toll-Like Receptors; D007371:Interferon-gamma