Stereoselective transition metal-catalysed higher-order carbocyclisation reactions.
Transition metal-catalysed higher-order carbocyclisation reactions represent an important class of reactions due to their ability to construct complex polycyclic systems in a highly selective and atom-economical fashion. A key and striking feature with these transformations is the dichotomy in reactivity that a substrate displays with different transition metal complexes, which is akin to the manner enzymes direct terpene biosynthesis. This tutorial review details the historical development of higher-order carbocyclisation reactions, specifically the variants of [m+2+2] that involve carbon-based pi-systems, where m = 2, 3 and 4, in the context of critical developments with various transition metal complexes.
Inglesby
Phillip A
PA
University of Liverpool, Department of Chemistry, Crown St., Liverpool, L69 7ZD, UK.
Evans
P Andrew
PA
D002384:Catalysis; D003500:Cyclization; D013237:Stereoisomerism; D013379:Substrate Specificity; D028561:Transition Elements / Q000737:chemistry*
D028561:Transition Elements