title: [Two elderly patients with advanced breast cancer successfully treated by tri-weekly docetaxel].
abstract: Case 1: An 86-year-old woman had an invasive breast cancer with dermal infiltration. Bone metastases were found in the femur and lumbar vertebrae. She was treated with 2 courses of 70 mg docetaxel (DOC) chemotherapy every 3 weeks, after which the tumor dramatically decreased in size. Following this treatment, she underwent a radical mastectomy. Case 2: An 80-year-old woman had a 10 cm tumor in the right breast. Lung and bone metastases were also found. Two 80 mg courses of DOC reduced the lung and bone metastases, and the size of the breast tumor. She underwent a local excision. Hormonal therapy is a standard treatment for hormone-sensitive breast cancer in elderly patients. It is suitable for patients who have a declining quality of life (QOL), although chemotherapy shows a higher response rate and takes less time than hormonal therapy. However, it is difficult to continue chemotherapy until pCR is achieved, even for chemotherapy-effective patients because the side effects of chemotherapy are severe. Therefore, local excision after chemotherapy is necessary for breast cancer patients to improve their QOL, even if there are distant metastatic lesions.
authors.affiliation: Dept. of Surgery, Tokushima Municipal Hospital.
authors.forename: Aya
authors.initials: A
authors.lastname: Okubo
authors.forename: Naoki
authors.initials: N
authors.lastname: Hino
authors.forename: Youko
authors.initials: Y
authors.lastname: Ikushima
authors.forename: Riho
authors.initials: R
authors.lastname: Mori
authors.forename: Sachiko
authors.initials: S
authors.lastname: Amano
authors.forename: Masaru
authors.initials: M
authors.lastname: Tsuyuguchi
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Sounaka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Wada
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Miyake
authors.forename: Takanori
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ikawa
authors.forename: Yorihiko
authors.initials: Y
authors.lastname: Ogata
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Naoya
authors.initials: N
authors.lastname: Kawakita
authors.forename: Chie
authors.initials: C
authors.lastname: Mikami
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D000077143:Docetaxel; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel