title: Parahippocampal corpora amylacea: case report.
abstract: OBJECTIVE
  Corpora amylacea (CA) normally accumulate within perivascular, subpial, and subependymal astrocytic processes. CA are associated with a number of conditions including normal aging, hippocampal sclerosis associated with temporal lobe epilepsy, multiple sclerosis, Lafora-type progressive myoclonic epilepsy, and adult polyglucosan body disease. Reports of massive localized accumulation of CA in the brain outside of these conditions are rare.
  
  
  METHODS
  A 49-year-old woman, with a long-standing history of migraine headaches, presented to her primary care provider for increased headache duration. Brain magnetic resonance imaging (MRI) revealed a left parahippocampal lesion, suggestive of low-grade glioma.
  
  
  METHODS
  Given the MRI suggestive of left parahippocampal glioma, left-sided frontotemporal craniotomy was performed for resection of the lesion. Specimens obtained during the operation revealed focal high-density accumulation of CA with no evidence of neoplasm, ischemia, or hypoxic injury.
  
  
  CONCLUSIONS
  This case illustrates the possibility that localized high-density CA accumulation can present as an intrinsic lesion on brain MRI. CA should be included in the differential diagnosis for patients presenting with brain MRI suggestive of nonenhancing space-occupying lesions.
authors.affiliation: Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Taylor J
authors.initials: TJ
authors.lastname: Abel
authors.forename: Adam O
authors.initials: AO
authors.lastname: Hebb
authors.forename: C Dirk
authors.initials: CD
authors.lastname: Keene
authors.forename: Donald E
authors.initials: DE
authors.lastname: Born
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Silbergeld
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005936:Glucans / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D008881:Migraine Disorders / Q000378:metabolism / Q000473:pathology; D020534:Parahippocampal Gyrus / Q000378:metabolism* / Q000473:pathology*
chemical_list: D005936:Glucans; C083094:polyglucosan