Infliximab in a patient with refractory necrotizing scleritis associated with relapsing polychondritis.
OBJECTIVE
To describe a case of necrotizing scleritis associated with relapsing polychondritis (RP), which was treated with infliximab.


METHODS
Observational case report.


RESULTS
A 60-year-old woman presented with a red eye. She had a past medical history of nose deformity, hearing problem, and tinnitus. Ophthalmological examination disclosed necrotizing scleritis and peripheral ulcerative keratitis. RP was diagnosed. The disease progressed despite treatment with methotrexate and cyclophosphamide, but infliximab resulted in a stabilization of the disease.


CONCLUSIONS
Infliximab could be a new weapon to treat refractory scleritis due to RP.
Jabbarvand
Mahmood
M
Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Fard
Masoud Aghsaei
MA
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D011081:Polychondritis, Relapsing / Q000150:complications*; D012074:Remission Induction / Q000379:methods; D015423:Scleritis / Q000188:drug therapy* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab