title: Advances in the genetics of familial renal cancer.
abstract: We discuss recent advances in the diagnosis and management of renal cell cancer (RCC) given the enhanced molecular genetics knowledge in this area. A number of hereditary renal cancer syndromes have been described, including von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, hereditary leiomyomatosis/RCC syndrome, and hereditary papillary renal cancer. Early molecular diagnosis now facilitates the management and prevention of RCC in families. Recommendations for screening in families are discussed.
authors.affiliation: Regional Medical Genetics Centre, Belfast City Hospital HSC Trust, Belfast, BT9 7AB, UK. patrick.morrison@belfasttrust.hscni.net
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Morrison
authors.forename: Deirdre E
authors.initials: DE
authors.lastname: Donnelly
authors.forename: A Brew
authors.initials: AB
authors.lastname: Atkinson
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Maxwell
mesh_terms: D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology