Tautomerism in drug discovery.
The influence of tautomerism on the precise structure of drugs and thus of their potential to interact with biological systems is discussed from thermodynamic and kinetic aspects. The types of tautomerism encountered in the structure of drugs in current use are surveyed together with the effect of pH, solvent polarity, and temperature.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Hall
C Dennis
CD
El-Gendy
Bahaa El-Dien M
Bel-D
Draghici
Bogdan
B
D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013816:Thermodynamics
D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations