title: Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia.
abstract: BACKGROUND
  Autofluorescence (AF) videoendoscopy has an advantage over ordinary videoendoscopy in the diagnosis of gastric neoplasias, and the aim of the present study was to evaluate the effectiveness of using the SAFE-3000 videoendoscopy system to diagnose superficial gastric neoplasias.
  
  
  METHODS
  Ordinary videoendoscopy, AF videoendoscopy, and chromoendoscopy (CE) were used to diagnose the tumor existence and extent in 14 patients with gastric adenoma, 40 patients with intestinal-type early gastric cancer (EGC) (10 protruded, and 30 depressed), and nine patients with diffuse-type EGC. The diagnostic accuracies of the three kinds of images were evaluated by comparison with the results of histopathological assessment of resected specimens.
  
  
  RESULTS
  For gastric adenomas the diagnostic accuracy between the AF images and white light (WL) images did not differ significantly, and for protruded intestinal-type EGCs and diffuse-type EGCs the diagnostic accuracy did not differ significantly between any of the types of images. For depressed intestinal-type EGCs, the diagnostic accuracy of AF images tended to be higher than that of the WL images (P < 0.05) and it was not significantly different from that of the CE images. The detection rate of pink or orange color in AF images was significantly higher for protruded intestinal-type EGCs than gastric adenomas (P = 0.005), depressed intestinal-type EGCs (P < 0.001), and diffuse-type EGCs (P = 0.027).
  
  
  CONCLUSIONS
  Autofluorescence videoendoscopy using the SAFE-3000 system for gastric neoplasias might be useful for diagnosing depressed intestinal-type early gastric cancers. The detection of orange or pink color in AF images may be efficacious in discriminating protruded intestinal-type early gastric cancers from gastric adenomas.
authors.affiliation: Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan. imaedahi@yahoo.co.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Imaeda
authors.forename: Naoki
authors.initials: N
authors.lastname: Hosoe
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kashiwagi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ida
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Saito
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Koichi
authors.initials: K
authors.lastname: Aiura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ogata
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kumai
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000368:Aged; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal; D004867:Equipment Design; D005260:Female; D005453:Fluorescence; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000473:pathology*; D014741:Video Recording