[Primary cutaneous aspergillosis complicated with invasive aspergillosis in an extremely preterm infant: case report and literature review].
Aspergillus is a ubiquitous fungus that can cause primary cutaneous aspergillosis in extremely low-birth-weight (ELBW) neonates, then be invasive and lead to death. ELBW neonates are particularly at risk because of decreased qualitative immune defenses and defects in the skin barrier. Broad-spectrum antimicrobial therapy and corticosteroids, often used in these patients, contribute to increased risk. We present a fatal case of primary cutaneous aspergillosis complicated with invasive aspergillosis, confirmed by autopsy, in an ELBW infant. The source of contamination was probably non-sterile disposable latex gloves used for neonatal care. The early recognition of this source led to its eviction for other hospitalized ELBW infants and no outbreak was observed.
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Service de réanimation néonatale et pédiatrique, centre hospitalier universitaire de Saint-Étienne, hopital Nord, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France. claire.stock@free.fr
Veyrier
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Magnin-Verschelde
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Duband
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Lavocat
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MP
Teyssier
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Berthelot
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D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D001344:Autopsy; D004209:Disposable Equipment; D017809:Fatal Outcome; D017575:Gloves, Protective / Q000009:adverse effects; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007840:Latex / Q000009:adverse effects*; D008297:Male; D009336:Necrosis; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology / Q000473:pathology
D000935:Antifungal Agents; D007840:Latex