Implications and challenges of connexin connections to cancer.
The idea that the gap junction family of proteins, connexins, are tumour suppressors has been widely supported through numerous cancer models. However, the paradigm that connexins and enhanced gap junctional intercellular communication is of universal benefit by restricting tumour growth has been challenged by more recent evidence that suggests a role for connexins in facilitating tumour progression and metastasis. Therefore, connexins might be better classified as conditional tumour suppressors that modulate cell proliferation, as well as adhesion and migration.
Naus
Christian C
CC
Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T-1Z3, Canada. Christian.naus@ubc.ca
Laird
Dale W
DW
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002450:Cell Communication; D017630:Connexins / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
D000970:Antineoplastic Agents; D017630:Connexins