Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties.
New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.
Kicha
Alla A
AA
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.
Ivanchina
Natalia V
NV
Huong
Trinh T T
TT
Kalinovsky
Anatoly I
AI
Dmitrenok
Pavel S
PS
Fedorov
Sergey N
SN
Dyshlovoy
Sergey A
SA
Long
Pham Q
PQ
Stonik
Valentin A
VA
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D016328:NF-kappa B / Q000235:genetics; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry*; D018808:Transcription Factor AP-1 / Q000235:genetics; D015533:Transcriptional Activation / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D000970:Antineoplastic Agents; D016328:NF-kappa B; D012503:Saponins; D018808:Transcription Factor AP-1; D016159:Tumor Suppressor Protein p53; C551832:archasteroside A; C551833:archasteroside B; C513250:regularoside A