title: Four new sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric-oxide production.
abstract: Four new sesquiterpenes including the novel sesquiterpene lactone (6R)-dehydroxysipanolinolide (1), two new eudesmane-type sesquiterpenes, curcolide (2) and curcodione (3), and a new xanthane-type sesquiterpene, curcumadionol (4), were isolated from Curcuma wenyujin Y. H. Chen et C. Ling, together with five known ones, 5-9. The structures of the new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1-9 on nitric-oxide production in lipopolysaccaride-activated macrophages were evaluated.
authors.affiliation: Department of Natural Products Chemistry 81#, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Road WenHua, Shenyang 110016, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lou
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: He
authors.forename: Kai-Feng
authors.initials: KF
authors.lastname: Peng
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D030024:Curcuma / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; D009569:Nitric Oxide