Development and assessment of a modified Pediatric Crohn Disease Activity Index.
The Pediatric Crohn Disease Activity Index (PCDAI) is an established and validated measure of disease activity in children with Crohn disease. However, its use in the research setting can be limited because of ambiguity of the subjective and anthropometric components of the index. Here we propose and evaluate a modified PCDAI (Mod PCDAI) consisting of the laboratory measures of the PCDAI plus C-reactive protein. This Mod PCDAI can provide an indication of disease activity because it correlates with the PCDAI, physicians' global assessment, and fecal calprotectin, and therefore may provide a suitable alternative to the PCDAI when required.
Leach
Steven T
ST
School of Women's and Children's Health, University of New South Wales, Randwick, Sydney, Australia.
Nahidi
Lily
L
Tilakaratne
Samantha
S
Day
Andrew S
AS
Lemberg
Daniel A
DA
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D003424:Crohn Disease / Q000145:classification* / Q000378:metabolism; D005243:Feces; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D010372:Pediatrics; D012720:Severity of Illness Index
D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D002097:C-Reactive Protein