Klebsiella pneumoniae bacteraemia complicating rotavirus gastroenteritis in two infants with glucocorticoid deficiency.
Rotavirus gastroenteritis was complicated by Klebsiella Pneumoniae bacteraemia in two infants with glucocorticoid deficient conditions who were treated with 'stress dose' hydrocortisone during their illness. Delayed healing in the context of glucocorticoid administration combined with damage from rotavirus infection may result in increased risk of mucosal invasion by gastrointestinal bacteria and subsequent enteric gram-negative bacteraemia.
Longmore
Danielle K
DK
Department of Endocrinology and Diabetes, Royal Children's Hospital, Brisbane, Australia. daniellelongmore@yahoo.com.au
Batch
Jennifer A
JA
McMahon
Sarah K
SK
Conwell
Louise S
LS
D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005759:Gastroenteritis / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000172:deficiency*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000627:therapeutic use; D007018:Hypopituitarism / Q000150:complications / Q000151:congenital / Q000188:drug therapy; D007223:Infant; D007710:Klebsiella Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D007711:Klebsiella pneumoniae; D008297:Male; D012400:Rotavirus Infections / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006854:Hydrocortisone