Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi.
In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC(50) values of 3.17 and 3.21 microM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
Zhang
Jian-ye
JY
State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China. jianyez2003@yahoo.com.cn
Tao
Li-yang
LY
Liang
Yong-ju
YJ
Chen
Li-ming
LM
Mi
Yan-jun
YJ
Zheng
Li-sheng
LS
Wang
Fang
F
She
Zhi-gang
ZG
Lin
Yong-cheng
YC
To
Kenneth Kin Wah
KK
Fu
Li-wu
LW
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D043982:Rhizophoraceae / Q000382:microbiology*; D013329:Structure-Activity Relationship
D000880:Anthraquinones; D000970:Antineoplastic Agents