title: New and classic families of secreted fungal heme peroxidases.
abstract: Heme-containing peroxidases secreted by fungi are a fascinating group of biocatalysts with various ecological and biotechnological implications. For example, they are involved in the biodegradation of lignocelluloses and lignins and participate in the bioconversion of other diverse recalcitrant compounds as well as in the natural turnover of humic substances and organohalogens. The current review focuses on the most recently discovered and novel types of heme-dependent peroxidases, aromatic peroxygenases (APOs), and dye-decolorizing peroxidases (DyPs), which catalyze remarkable reactions such as peroxide-driven oxygen transfer and cleavage of anthraquinone derivatives, respectively, and represent own separate peroxidase superfamilies. Furthermore, several aspects of the "classic" fungal heme-containing peroxidases, i.e., lignin, manganese, and versatile peroxidases (LiP, MnP, and VP), phenol-oxidizing peroxidases as well as chloroperoxidase (CPO), are discussed against the background of recent scientific developments.
authors.affiliation: Department of Environmental Biotechnology, International Graduate School of Zittau, Markt 23, 02763, Zittau, Germany. hofrichter@ihi-zittau.de
authors.forename: Martin
authors.initials: M
authors.lastname: Hofrichter
authors.forename: René
authors.initials: R
authors.lastname: Ullrich
authors.forename: Marek J
authors.initials: MJ
authors.lastname: Pecyna
authors.forename: Christiane
authors.initials: C
authors.lastname: Liers
authors.forename: Taina
authors.initials: T
authors.lastname: Lundell
mesh_terms: D000595:Amino Acid Sequence; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry / Q000145:classification / Q000201:enzymology* / Q000235:genetics; D006418:Heme / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010544:Peroxidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D021381:Protein Transport; D016415:Sequence Alignment
chemical_list: D005656:Fungal Proteins; D006418:Heme; D010544:Peroxidases