title: Anti-cyclic citrullinated peptide and rheumatoid factor in HIV positive patients.
abstract: The aim of this study was to determine the difference of anti-CCP and RF between HIV positive patients and a healthy control group. The rheumatological complications in HIV positive patients are rather common and are recognized as a serious problem that requires more attention. Anti-CCP and RF are the only laboratory tools for rheumatoid disorder diagnostics and predictors of the course of the disease. We determined anti-CCP and RF in sera of 35 healthy volunteers and 45 HIV positive patients. Data were compared using chi-square test, Mann-Whitney test and ROC curve statistics. Both parameters were significantly higher in HIV positive patients, and significant differences between areas under the anti-CCP and RF curves were observed. Median value for anti-CCP in HIV positive patients was higher than the reference interval, and RF values were, in the reference interval, suggested by the manufacturer. Both anti-CCP and RF are significantly higher in HIV positive patients. ROC analysis showed that anti-CCP distinguishes the two groups better than RF. Because of that, it would be of a great interest to investigate the HIV positive patients after the detailed rheumatological examination.
authors.affiliation: Clinical Department for Laboratory Diagnostics, Dubrava University Hospital, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Romic
authors.forename: Lovorka
authors.initials: L
authors.lastname: Derek
authors.forename: Vitomir
authors.initials: V
authors.lastname: Burek
authors.forename: Adriana
authors.initials: A
authors.lastname: Unic
authors.forename: Tihana
authors.initials: T
authors.lastname: Serdar
authors.forename: Domagoj
authors.initials: D
authors.lastname: Marijancevic
authors.forename: Jadranka
authors.initials: J
authors.lastname: Morovic-Vergles
authors.forename: Josko
authors.initials: J
authors.lastname: Mitrovic
authors.forename: Mladen
authors.initials: M
authors.lastname: Petrovecki
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000037:antagonists & inhibitors* / Q000276:immunology*; D012372:ROC Curve; D012217:Rheumatoid Factor / Q000097:blood*
chemical_list: D000906:Antibodies; D015415:Biomarkers; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor