Altered effect of preceding response execution on inhibitory processing in children with AD/HD: An ERP study.
The electrophysiological findings in children with attention-deficit/hyperactivity disorder (AD/HD) have been repeatedly examined through a series of event-related potential (ERP) studies involving tasks that require inhibitory processing. Previous behavioral studies showed that the difficulty in response withholding for AD/HD children is enhanced by the preceding Go-trial. However, studies on the effects of the preceding response execution on the inhibitory ERP components in children with AD/HD have been scarce. Twelve children with AD/HD (6 with predominantly inattentive type, 6 with combined type) and 12 exhibiting typical development took a visual continuous performance test (CPT) involving Go/NoGo methodology. The effect of the preceding trial was analyzed by comparing ERP components and performance data between switch and repeat trials. Within-group comparison revealed that a significantly larger amplitude of NoGo-N200 for NoGo-switch (Go/NoGo) versus NoGo-repeat (NoGo/NoGo) was observed across sagittal regions in the control group but not in the AD/HD one. Between-group comparison revealed that the amplitude of NoGo-N200 for NoGo-switch across sagittal regions was significantly smaller in the AD/HD group than in the control one. The effect of the preceding trial on NoGo-N200 did not differ between two AD/HD subtypes. Moreover, the amplitudes and latencies of the ERP components elicited by Go-trials were not influenced by the type of preceding trial. These results suggested that the effect of preceding response execution on NoGo-N200 is greatly affected in children with AD/HD.
Inoue
Yuki
Y
Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. yinoue@ncnp.go.jp
Inagaki
Masumi
M
Gunji
Atsuko
A
Furushima
Wakana
W
Okada
Hiroyuki
H
Sasaki
Hiroshi
H
Omori
Takashi
T
Takeichi
Hiroshige
H
Kaga
Makiko
M
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D005071:Evoked Potentials / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D010775:Photic Stimulation / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*