Epidermal lipids, barrier function, and desquamation.
Based on recent morphologic, histochemical, and biochemical data, we propose a heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum corneum barrier function and desquamation. The evidence in favor of the model and several predictions based on the model are surveyed in this review.
Elias
P M
PM
Dermatology Service, Veterans Administration Medical Center, and Department of Dermatology, University of California School of Medicine, San Francisco, California, U.S.A.