Advances in the genetics of familial renal cancer.
We discuss recent advances in the diagnosis and management of renal cell cancer (RCC) given the enhanced molecular genetics knowledge in this area. A number of hereditary renal cancer syndromes have been described, including von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, hereditary leiomyomatosis/RCC syndrome, and hereditary papillary renal cancer. Early molecular diagnosis now facilitates the management and prevention of RCC in families. Recommendations for screening in families are discussed.
Morrison
Patrick J
PJ
Regional Medical Genetics Centre, Belfast City Hospital HSC Trust, Belfast, BT9 7AB, UK. patrick.morrison@belfasttrust.hscni.net
Donnelly
Deirdre E
DE
Atkinson
A Brew
AB
Maxwell
Alexander P
AP
D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology