title: Anti-adhesive effect and safety of sodium hyaluronate and sodium carboxymethyl cellulose solution in thyroid surgery.
abstract: OBJECTIVE
  A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the anti-adhesive effect and safety of a newly developed HA-CMC solution in thyroidectomy.
  
  
  METHODS
  Seventy-four patients who underwent thyroidectomy were prospectively randomized. In the study group of 38 patients, 5 mL HA-CMC solution was applied to the operative field after thyroidectomy. The subjects were asked about adhesive symptoms using a four-item questionnaire at 2 weeks, 2 months and 6 months after surgery. In addition, three items on the appearance of neck wrinkles and scars were evaluated by a physician. Each item was scored from 0 to 10.
  
  
  RESULTS
  The mean (+/- standard deviation) total adhesion score at each visit was 15.22 +/- 8.99, 10.42 +/- 8.41, and 7.24 +/- 5.83 for the control group and 19.29 +/- 9.71, 9.46 +/- 5.71, and 6.03 +/- 4.32 for the study group. Total adhesion scores for both groups decreased with time (p < 0.001), but no significant differences were noted between the two groups (p > 0.066). There were no complications related to the HA-CMC solution.
  
  
  CONCLUSIONS
  The HA-CMC solution did not decrease subjective or objective postoperative adhesion in patients undergoing thyroid surgery, although it was biologically safe.
authors.affiliation: Department of Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Won Seo
authors.initials: WS
authors.lastname: Park
authors.forename: Yoo Seung
authors.initials: YS
authors.lastname: Chung
authors.forename: Kyu Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Hoon Yub
authors.initials: HY
authors.lastname: Kim
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Choe
authors.forename: Suck Hwan
authors.initials: SH
authors.lastname: Koh
authors.forename: Yeo-Kyu
authors.initials: YK
authors.lastname: Youn
mesh_terms: D000328:Adult; D000368:Aged; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013965:Thyroidectomy / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium