title: Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetes.
abstract: We examined the association between diabetic retinopathy and monocyte chemoattractant protein (MCP)-1 A-2518G polymorphism in 3802 Japanese type 2 diabetic subjects. The prevalence of diabetic retinopathy was higher as the number of G alleles increased, suggesting that the G allele of this polymorphism is a susceptibility allele for diabetic retinopathy.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. katakami@medone.med.osaka-u.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Katakami
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Taka-aki
authors.initials: TA
authors.lastname: Matsuoka
authors.forename: Kenichi
authors.initials: K
authors.lastname: Imamura
authors.forename: Fukashi
authors.initials: F
authors.lastname: Ishibashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kanda
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Osonoi
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamori
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Yamasaki
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D018932:Chemokine CCL2 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D022242:Pneumococcal Vaccines; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines