title: Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment.
abstract: OBJECTIVE
  To investigate associations of the Mediterranean diet (MeDi) components and the MeDi score with mild cognitive impairment (MCI).
  
  
  METHODS
  Participants (aged 70-89 years) were clinically evaluated to assess MCI and dementia, and completed a 128-item food frequency questionnaire.
  
  
  RESULTS
  163 of 1,233 nondemented persons had MCI. The odds ratio of MCI was reduced for high vegetable intake [0.66 (95% CI = 0.44-0.99), p = 0.05] and for high mono- plus polyunsaturated fatty acid to saturated fatty acid ratio [0.52 (95% CI = 0.33-0.81), p = 0.007], adjusted for confounders. The risk of incident MCI or dementia was reduced in subjects with a high MeDi score [hazard ratio = 0.75 (95% CI = 0.46-1.21), p = 0.24].
  
  
  CONCLUSIONS
  Vegetables, unsaturated fats, and a high MeDi score may be beneficial to cognitive function.
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA. roberts.rosebud @ mayo.edu
authors.forename: Rosebud O
authors.initials: RO
authors.lastname: Roberts
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Cha
authors.forename: Teresa J H
authors.initials: TJ
authors.lastname: Christianson
authors.forename: V Shane
authors.initials: VS
authors.lastname: Pankratz
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ivnik
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Helen M
authors.initials: HM
authors.lastname: O'Connor
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000523:psychology*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000523:psychology*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology / Q000523:psychology; D004034:Diet Surveys; D038441:Diet, Mediterranean; D005224:Fats, Unsaturated; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D009518:New York / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires; D014675:Vegetables
chemical_list: D005224:Fats, Unsaturated