Small RNAs guide hematopoietic cell differentiation and function.
MicroRNAs (miRNAs) are key regulators of gene expression that help direct normal differentiation and malignant transformation of hematopoietic cells. This review summarizes our current knowledge of how miRNAs function in normal and malignant hematopoiesis and how miRNAs might be applied for disease treatment.
Navarro
Francisco
F
Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Lieberman
Judy
J
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
D035683:MicroRNAs