Neuropeptide S mitigates spatial memory impairment induced by rapid eye movement sleep deprivation in rats.
Rapid eye movement (REM) sleep deprivation causes learning and memory deficits. Neuropeptide S, a newly discovered neuropeptide, has been shown to regulate arousal, anxiety, and may enhance long-term memory formation and spatial memory. However, it is unknown whether neuropeptide S could improve the REM sleep deprivation-induced memory impairment. Here, we report that 72-h REM sleep deprivation in rats resulted in spatial memory impairment and reduced phosphorylation level of cAMP-response element binding protein in the hippocampus, both of which were reversed by central administration of neuropeptide S. The results suggest that neuropeptide S mitigates spatial memory impairment in rats induced by 72-h REM sleep deprivation, possibly through activating cAMP-response element binding protein phosphorylation in the hippocampus.
Zhao
Zhengqing
Z
Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
Huang
Liuqing
L
Wu
Huijuan
H
Li
Yanpeng
Y
Zhang
Lin
L
Yin
You
Y
Xiang
Zhenghua
Z
Zhao
Zhongxin
Z
D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology* / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D010766:Phosphorylation; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012892:Sleep Deprivation / Q000150:complications* / Q000378:metabolism*; D012895:Sleep, REM / Q000502:physiology; D013028:Space Perception / Q000502:physiology; D013997:Time Factors
D017362:Cyclic AMP Response Element-Binding Protein; D009479:Neuropeptides; C534458:neuropeptide S, rat