title: High affinity binding site for (+) amphetamine in rat hypothalamus: Fact or artefact?
abstract: We studied the binding of (+)(3)H-amphetamine to membrane sites from rat hypothalamus. Our experiments demonstrate the possible existence of artefactual results in previous studies due to the inadequate use of a filtration technique. In addition, it seems that monoamine oxidase A might be a component of the complex mixture of binding sites which are recognized by (+)(3)H-amphetamine since harmaline and monoamine oxidase A selective inhibitors are good displacers of this ligand.
authors.affiliation: Centre de Recherche Delalande, 10 rue des Carrières, F-92500 Rueil-Malmaison, France.
authors.forename: A
authors.initials: A
authors.lastname: Lesage
authors.forename: M
authors.initials: M
authors.lastname: Strolin Benedetti
authors.forename: J F
authors.initials: JF
authors.lastname: Rumigny