The effects of carbon disulfide on male sexual function and semen quality.
A cross-sectional study was initiated to clarify whether the current level of exposure to carbon disulphide (CS(2)) is low enough to prevent occurrence of subclinical health impairments. This paper describes the effects of exposure to CS(2) on male sexual function and semen quality in a baseline observation. The effects of CS(2) on male sexual function were evaluated, including number of sexual encounters and length of sexual encounters related to solvents in 80 male workers exposed to CS(2) and 49 reference workers from the filature and cotton pulp departments of a fabric factory in China. And the semen samples were obtained from 43 of the exposed and 35 of the control. Adjustment was made for potential confounding factors such as age or alcohol drinking. Exposure to CS(2) was dichotomized by job type. The rate of sexual dysfunction was higher, number of sexual encounters was lower, and length of sexual encounters was shorter compared with the control (p < 0.001). It was indicated that exposed workers had fewer semen quantity, longer liquefaction time, lower acrosomal membrane integrity rate, vitality and density, and more deformity of semen than the control (p < 0.01). The age and type of work played the most important roles in sexual dysfunction by the multinomial logistic regression analysis (p < 0.01).The duration of exposure had the effect on sexual function and semen quality but no statistical significance (p > 0.05). Clinical effects on the male sexual function and semen quality were found in the workers exposed to CS(2).
Ma
Ji-Ying
JY
Department of Environmental & Occupational Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Ji
Jia-Jia
JJ
Qing Ding
Liu
Wei-Dong
WD
Wang
Si-Quan
SQ
Ning Wang
Chen
Guo-Yuan
GY
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D002246:Carbon Disulfide / Q000009:adverse effects* / Q000494:pharmacology; D002617:Chemical Industry; D002681:China; D003430:Cross-Sectional Studies; D006801:Humans; D007221:Industry; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016273:Occupational Exposure / Q000009:adverse effects; D012661:Semen / Q000187:drug effects*; D055101:Semen Analysis; D012725:Sexual Behavior / Q000187:drug effects*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*
D002246:Carbon Disulfide