[Visual impairment in juvenile diabetes mellitus due to optic atrophy: Wolfram's syndrome].
Wolfram's syndrome is a rare neurodegenerative disorder, which usually first manifests itself around the age of 6 years. The diagnosis can be made based on the characteristics incorporated in the 'DIDMOAD' acronym: diabetes insipidus, diabetes mellitus, optic atrophy and deafness. We present 2 boys, diagnosed with diabetes mellitus at the age of 5 and 4 years respectively. Both children developed optic atrophy over the years. These 2 cases illustrate that alongside diabetic retinopathy, possible syndromes, such as Wolfram's syndrome, should also be considered in children with diabetes mellitus and visual impairment.
Immink
Annelies
A
HagaZiekenhuis, locatie Juliana Kinderziekenhuis, Den Haag, The Netherlands. anneliesimmink@gmail.com
Reeser
H Maarten
HM
Brus
Frank
F
D001766:Blindness / Q000175:diagnosis / Q000209:etiology; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008297:Male; D009896:Optic Atrophy / Q000175:diagnosis / Q000209:etiology*; D014929:Wolfram Syndrome / Q000150:complications* / Q000175:diagnosis