title: Cellulose triacetate dialyzer reduces platelet loss during continuous veno-venous hemofiltration.
abstract: Thrombocytopenia is a common complication in patients receiving continuous veno-venous hemofiltration (CVVH) in the intensive care unit. The hemofilter itself plays an important role in the genesis of thrombocytopenia. The present study was undertaken to test whether there were differences in platelet loss and activation during CVVH with a polysulfone (PS) hemofilter or a cellulose triacetate (CTA) dialyzer. 96 patients with thrombocytopenia and acute kidney injury requiring CVVH were randomly assigned to four groups receiving low-molecular-weight heparin (LMWH) PS (n = 24), LMWH CTA (n = 24), no anticoagulation PS (n = 24), and no anticoagulation CTA (n = 24), respectively. We found a significant decrease in platelet counts, but an increased platelet activation with the PS hemofilter in patients who received no anticoagulation. There was no significant decrease in platelet counts and activation in the CTA group. The cellulose membranes could be an effective alternative to the standard synthetic membranes in patients at high risk for thrombocytopenia during CVVH.
authors.affiliation: Department of Nephrology, Guangdong General Hospital, Guangzhou, PR China.
authors.forename: Shuangxin
authors.initials: S
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Xinling
authors.initials: X
authors.lastname: Liang
authors.forename: Yong
authors.initials: Y
authors.lastname: Su
authors.forename: Yongzhen
authors.initials: Y
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Ye
authors.forename: Lixia
authors.initials: L
authors.lastname: Xu
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Xia
authors.forename: Chaoshen
authors.initials: C
authors.lastname: He
authors.forename: Jianchao
authors.initials: J
authors.lastname: Ma
authors.forename: Yiming
authors.initials: Y
authors.lastname: Tao
authors.forename: Hen
authors.initials: H
authors.lastname: Ye
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002482:Cellulose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006440:Hemofiltration / Q000009:adverse effects* / Q000295:instrumentation; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D011108:Polymers / Q000009:adverse effects / Q000627:therapeutic use; D013450:Sulfones / Q000009:adverse effects / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology* / Q000517:prevention & control
chemical_list: D006495:Heparin, Low-Molecular-Weight; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D002482:Cellulose; C024671:cellulose triacetate