p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.
Anderson
Deborah H
DH
D058543:Class Ia Phosphatidylinositol 3-Kinase / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction
D007295:Inositol Phosphates; D021122:Protein Subunits; C118500:inositol 3,4,5-trisphosphate; D058543:Class Ia Phosphatidylinositol 3-Kinase; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human