New estrogenic compounds isolated from Broussonetia kazinoki.
Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.
Lee
Da Yeon
DY
College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
Kim
Do Hee
DH
Lee
Hwa Jin
HJ
Lee
YoungJoo
Y
Ryu
Kwang Hee
KH
Jung
Bo-In
BI
Song
Yun Seon
YS
Ryu
Jae-Ha
JH
D031623:Broussonetia / Q000737:chemistry*; D004967:Estrogens / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D048789:Phytoestrogens / Q000302:isolation & purification / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D020218:Response Elements / Q000187:drug effects; D014158:Transcription, Genetic / Q000187:drug effects
D004967:Estrogens; D008024:Ligands; D010636:Phenols; D048789:Phytoestrogens; D011960:Receptors, Estrogen; C524287:broussonin A