Serological markers of autoimmunity in pregnant women with polycystic ovary syndrome: a pilot study.
BACKGROUND
Gestational diabetes mellitus (GDM) is highly prevalent in women with polycystic ovary syndrome (PCOS). Women with GDM have considerable risk for developing both type 1 and type 2 diabetes.


OBJECTIVE
To evaluate the prevalence of anti-GAD65 and anti-IA2 auto-antibodies in Chilean pregnant women with GDM, normal pregnancy (NP) and with PCOS (PPCOS) to establish whether in PCOS women GDM is partially induced by auto-antibodies.


METHODS
Women with singleton pregnancies matched by age and gestational age were included: 50 GDM, 59 NP and 50 PPCOS. During gestational weeks 22-28, a 2-h, 75 g oral glucose tolerance test was performed, with measurement of glucose, insulin, lipids and auto-antibodies.


RESULTS
A highly prevalence of anti-GAD65 antibodies (12%) was observed in women with GDM. PPCOS and NP women showed a similar distribution of anti-GAD65 antibodies (2.0% and 1.7%, respectively). Anti-IA2 antibodies were present in 4.0% of women with GDM, in 1.7% of NP women and 2.0% PPCOS women.


CONCLUSIONS
A highly prevalence of anti-GAD65 was observed in women with GDM which is in agreement with previous studies. Nevertheless, the frequency of these auto-antibodies was very low in NP and PPCOS women.
Pérez-Bravo
Francisco
F
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile. fperez@med.uchile.cl
Carrasco
Elena
E
Echiburú
Bárbara
B
Maliqueo
Manuel
M
Diaz
Jaime
J
Sir-Petermann
Teresa
T
D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D001786:Blood Glucose / Q000378:metabolism; D016009:Chi-Square Distribution; D016640:Diabetes, Gestational / Q000097:blood / Q000276:immunology*; D005260:Female; D005951:Glucose Tolerance Test; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000097:blood; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000276:immunology*; D011247:Pregnancy; D015995:Prevalence; D014280:Triglycerides / Q000097:blood
D001323:Autoantibodies; D001786:Blood Glucose; C096322:ICA512 autoantibody; D007328:Insulin; D014280:Triglycerides; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2