title: Levetiracetam-induced seizure aggravation associated with continuous spikes and waves during slow sleep in children with refractory epilepsies.
abstract: We present a patient with cryptogenic focal epilepsy and another with Dravet syndrome, who experienced seizure aggravation and negative myoclonus, associated with continuous spikes and waves during slow sleep, induced by levetiracetam. For both patients levetiracetam was discontinued, and there was significant improvement of this particular electroclinical picture.
authors.affiliation: Neurology Department, Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina. rhcaraballo@arnet.com.ar
authors.forename: Roberto H
authors.initials: RH
authors.lastname: Caraballo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Cersósimo
authors.forename: Cecilia
authors.initials: C
authors.lastname: De los Santos
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D004831:Epilepsies, Myoclonic / Q000139:chemically induced / Q000175:diagnosis; D004828:Epilepsies, Partial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis; D012890:Sleep / Q000187:drug effects*; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam