title: Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction.
abstract: BACKGROUND
  A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma.
  
  
  METHODS
  In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn.
  
  
  RESULTS
  Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides.
  
  
  CONCLUSIONS
  We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction.
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA. cym2003@med.cornell.edu
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Magro
authors.forename: Andres E
authors.initials: AE
authors.lastname: Cruz-Inigo
authors.forename: Henry
authors.initials: H
authors.lastname: Votava
authors.forename: Michael
authors.initials: M
authors.lastname: Jacobs
authors.forename: David
authors.initials: D
authors.lastname: Wolfe
authors.forename: A Neil
authors.initials: AN
authors.lastname: Crowson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects; D001706:Biopsy; D003875:Drug Eruptions / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000927:Anticonvulsants; D000928:Antidepressive Agents