title: The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials.
abstract: BACKGROUND
  The subject of death and bereavement in the context of randomised controlled trials in neonatal or paediatric intensive care is under-researched. The objectives of this phase of the Bereavement and RAndomised ControlLEd Trials (BRACELET) Study were to determine trial activity in UK neonatal and paediatric intensive care (2002-06); numbers of deaths before hospital discharge; and variation in mortality across intensive care units and trials and to determine whether bereavement support policies were available within trials. These are essential prerequisites to considering the implications of future policies and practice subsequent to bereavement following a child's enrollment in a trial.
  
  
  METHODS
  The units survey involved neonatal units providing level 2 or 3 care, and paediatric units providing level II care or above; the trials survey involved trials where allocation was randomized and interventions were delivered to intensive care patients, or to parents but designed to affect patient outcomes.
  
  
  RESULTS
  Information was available from 191/220 (87%) neonatal units (149 level 2 or 3 care); and 28/32 (88%) paediatric units. 90/177 (51%) eligible responding units participated in one or more trial (76 neonatal, 14 paediatric) and 54 neonatal units and 6 paediatric units witnessed at least one death. 50 trials were identified (36 neonatal, 14 paediatric). 3,137 babies were enrolled in neonatal trials, 210 children in paediatric trials. Deaths ranged 0-278 (median [IQR interquartile range] 2 [1, 14.5]) per neonatal trial, 0-4 (median [IQR] 1 [0, 2.5]) per paediatric trial. 534 (16%) participants died post-enrollment: 522 (17%) in neonatal trials, 12 (6%) in paediatric trials. Trial participants ranged 1-236 (median [IQR] 21.5 [8, 39.8]) per neonatal unit, 1-53 (median [IQR] 11.5 [2.3, 33.8]) per paediatric unit. Deaths ranged 0-37 (median [IQR] 3.5 [0.3, 8.8]) per neonatal unit, 0-7 (median [IQR] 0.5 [0, 1.8]) per paediatric unit. Three trials had a formal policy for responding to bereavement.
  
  
  CONCLUSIONS
  A substantial number of deaths after trial enrollment were identified, distributed over many trials and units. Few trial teams had responses to bereavement in place. Those with the largest numbers of deaths might be best placed to collaborate in developing and assessing responses to bereavement.
authors.affiliation: Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Claire
authors.initials: C
authors.lastname: Snowdon
authors.forename: Sheila E
authors.initials: SE
authors.lastname: Harvey
authors.forename: Peter
authors.initials: P
authors.lastname: Brocklehurst
authors.forename: Robert C
authors.initials: RC
authors.lastname: Tasker
authors.forename: Martin P Ward
authors.initials: MP
authors.lastname: Platt
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Allen
authors.forename: Diana
authors.initials: D
authors.lastname: Elbourne
mesh_terms: D002648:Child; D019538:Health Care Surveys; D017051:Hospice Care / Q000706:statistics & numerical data; D017052:Hospital Mortality; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D016032:Randomized Controlled Trials as Topic / Q000401:mortality* / Q000639:trends*; D006113:United Kingdom / Q000453:epidemiology