Allergy and glioma risk: test of association by genotype.
Although epidemiological studies have suggested an association between atopy and glioma risk, these observations have been based on self-reporting of allergic conditions raising the possibility that associations may be noncausal and arise as a consequence of bias, reverse causation or other artifacts. Genetic information provides an alternative approach to investigate the relationship avoiding such biases. We analyzed 1,878 glioma cases and 3,670 controls for variants at 2q12, 5q12.1, 11q13 and 17q21 that are associated with asthma or eczema risk at p < 5.0 × 10(-7) . The SNP rs7216389, which tags the 3' flanking region of ORMDL3 at 17q21 and has been associated with childhood asthma, was correlated with increased glioma risk (OR = 1.10; 95% CI: 1.01-1.19). These data provide evidence for a correlation between asthma susceptibility and glioma risk and illustrate the value of using genetics as an investigative tool for developing etiological hypotheses.
Dobbins
Sara E
SE
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Hosking
Fay J
FJ
Shete
Sanjay
S
Armstrong
Georgina
G
Swerdlow
Anthony
A
Liu
Yanhong
Y
Yu
Robert
R
Lau
Ching
C
Schoemaker
Minouk J
MJ
Hepworth
Sarah J
SJ
Muir
Kenneth
K
Bondy
Melissa
M
Houlston
Richard S
RS
D000483:Alleles; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics*; D004485:Eczema; D005819:Genetic Markers; D005838:Genotype; D005910:Glioma / Q000150:complications / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011110:Polymorphism, Genetic; D012306:Risk
D005819:Genetic Markers