Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults characterized by high viral genome load within circulating natural killer cells.
Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.
Fox
C P
CP
School of Cancer Sciences, University of Birmingham, Edgbaston, UK. c.p.fox@bham.ac.uk
Shannon-Lowe
C
C
Gothard
P
P
Kishore
B
B
Neilson
J
J
O'Connor
N
N
Rowe
M
M
D001856:Bone Marrow Examination; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019562:Viral Load; D055815:Young Adult