title: Clinical and microbiological spectrum of necrotizing fasciitis in surgical patients at a Philippine university medical centre.
abstract: OBJECTIVE
  The study describes the clinical characteristics, bacteriology and risk factors for mortality of patients with necrotizing fasciitis (NF), seen in a university medical centre.
  
  
  METHODS
  The medical charts of NF patients admitted to the institution from January 2004 to July 2007 were retrieved and reviewed retrospectively.
  
  
  RESULTS
  The majority of the 67 patients included in the study presented with localized nonspecific inflammatory manifestations: tenderness (94%), warmth (86%), oedema (76%), skin necrosis (75%), and ulceration (68%). Diabetes mellitus (22%) was the most common predisposing medical condition. The most frequent isolates were Escherichia coli (44%), Acinetobacter baumannii (19%), Staphylococcus aureus (15%) and Enterococcus faecium (15%). Overall mortality rate was 36%. Risk factors significantly associated with mortality were truncal involvement (p = 0.034), leukocytosis (p = 0.038), acidosis (p = 0.001), hypoalbuminaemia (p = 0.004), hypocalcaemia (p = 0.000) and hyponatraemia (p = 0.023). Logistic regression analysis revealed acidosis [p < 0.05, odds ratio (OR) = 9] and hypoalbuminaemia (p < 0.05, OR = 14) as significant independent risk factors for mortality.
  
  
  CONCLUSIONS
  The identified risk factors can inform clinicians of increased mortality risks for certain patients with NF. They should serve as a trigger for more aggressive surgical and critical care, and antimicrobial therapy for these patients.
authors.affiliation: Division of Surgical Critical Care, Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Philippines.
authors.forename: Vincent Bryan D G
authors.initials: VB
authors.lastname: Salvador
authors.forename: Michael D
authors.initials: MD
authors.lastname: San Juan
authors.forename: James A
authors.initials: JA
authors.lastname: Salisi
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Consunji
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D019115:Fasciitis, Necrotizing / Q000175:diagnosis* / Q000382:microbiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010679:Philippines; D012189:Retrospective Studies; D012307:Risk Factors