title: [Study on processing principle of Aconitum pendulum].
abstract: OBJECTIVE
  To study the processing principles of different processed products of Aconitum pendulum.
  
  
  METHODS
  Using high performance liquid chromatography and acute toxicity test to compare the changes in chemical composition and toxicity of the roots and processed products of A. pendulum.
  
  
  RESULTS
  The main toxic components of the roots of A. pendulum were aconitine, deoxyaconitine and 3-acetylaconitine. The contents of these three alkaloids were significantly reduced in processed products, while benzoylaconitine significantly increased. In addition, processed products emerged aconine, polyschistine-D, beyzoyldeoxyaconine, 16-epi-pyroaconitine and 16-epi-pyrodeoxyaconitine. From the structural analysis, these new emerged compounds transformed from the aconitine, deoxyaconitine and 3-acetylaconitine.
  
  
  CONCLUSIONS
  Different processing methods can reduce the toxicity of the roots of A. pendulum. Processing principle is ester hydrolysis and high-temperature pyrolysis.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. superwangyj@126.com
authors.forename: Yujie
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Huiping
authors.initials: H
authors.lastname: Tian
authors.forename: Chenjuan
authors.initials: C
authors.lastname: Zeng
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yao
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives / Q000032:analysis; D031841:Aconitum / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice
chemical_list: C057219:deoxyaconitine; C031321:3-acetylaconitine; D000157:Aconitine