title: Cases with manifestation of chemodectoma diagnosed in dogs in Department of Internal Diseases with Horses, Dogs and Cats Clinic, Veterinary Medicine Faculty, University of Environmental and Life Sciences, Wroclaw, Poland.
abstract: In the period of 3 years, 9 tumours of chemodectoma were supravitally diagnosed and histopathologically verified in dogs. In this period 15 351 dogs were admitted to the Clinic of Dogs and Cats and 2 145 dogs were examined in the cardiological outpatient clinic for dogs. This tumour is located in a typical place--at the base of the heart. Most frequently the tumour manifested in older boxers. Only in one case such a tumour was diagnosed in another breed of dogs. The tumours ranged in size between 3 and 16 cm in diameter. The principal sign accompanying tumours of cardiac base involved dyspnoea but in 3 cases the tumours yielded no clinical signs. All the diagnoses were additionally verified using immunohistochemical examination. We used antibodies to chromogranin A (clone DAK-A3 1:100), synaptophysin (clone SY38 1:20) and neuron-specific enolase (clone BBS/NC/VI-H14 1:150). An immunohistochemical examination is vital for the diagnosis since it allows to differentiate histologically distinct types of neoplasia which may locate in the same site and may manifest a similar histological pattern.
authors.affiliation: Department of Internal Diseases with Horses, Dogs and Cats Clinic, Veterinary Medicine Faculty, University of Environmental and Life Sciences Wroclaw 50-366, Poland. agnieszkann@poczta.onet.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Noszczyk-Nowak
authors.forename: Marcin
authors.initials: M
authors.lastname: Nowak
authors.forename: Urszula
authors.initials: U
authors.lastname: Paslawska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Atamaniuk
authors.forename: Jozef
authors.initials: J
authors.lastname: Nicpon
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D014408:Biomarkers, Tumor / Q000276:immunology; D001947:Breeding; D053379:Chromogranin A / Q000276:immunology; D004283:Dog Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004285:Dogs; D004417:Dyspnea / Q000503:physiopathology; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D009206:Myocardium / Q000473:pathology; D010236:Paraganglioma, Extra-Adrenal / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D011044:Poland; D016708:Synaptophysin / Q000276:immunology; D014495:Universities; D014730:Veterinary Medicine
chemical_list: D000906:Antibodies; D014408:Biomarkers, Tumor; D053379:Chromogranin A; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase