Glycosylation with glycosyl N-phenyltrifluoroacetimidates (PTFAI) and a perspective of the future development of new glycosylation methods.
The glycosyl N-phenyltrifluoroacetimidates (PTFAI) have within the last ten years been applied in the synthesis of a wide variety of the oligosaccharides and glycoconjugates. Especially, these donors are found advantageous in glycosidic coupling with 'arming' sugar donors, ketose donors, and with less nucleophilic acceptors. A comprehensive review of the PTFAI donors is provided in a hope to reflect from a particular angle the current status and future trend of the glycosylation chemistry.
Yu
Biao
B
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. byu@mail.sioc.ac.cn
Sun
Jiansong
J
D000577:Amides / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry; D006031:Glycosylation; D006877:Hydroxamic Acids / Q000737:chemistry; D007096:Imidoesters / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry
D000577:Amides; D006001:Glycoconjugates; D006877:Hydroxamic Acids; D007096:Imidoesters; D009844:Oligosaccharides