title: Pot1 and telomere maintenance.
abstract: Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice.
authors.affiliation: Howard Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, MO 64110, USA. peb@stowers.org
authors.forename: Peter
authors.initials: P
authors.lastname: Baumann
authors.forename: Carolyn
authors.initials: C
authors.lastname: Price
mesh_terms: D000818:Animals; D005656:Fungal Proteins / Q000235:genetics; D020440:Gene Duplication; D017125:Genes, Protozoan; D006801:Humans; D051379:Mice; D009348:Nematoda / Q000235:genetics; D010944:Plants / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D000089804:Shelterin Complex; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000502:physiology*; D034501:Telomere-Binding Proteins / Q000235:genetics*; D015003:Yeasts / Q000235:genetics
chemical_list: D005656:Fungal Proteins; C440849:POT1 protein, human; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D019098:Telomerase