[Benz(a)pyrene antibodies are a marker of carcinogenic load in coal-processing workers].
The authors studied benz(a)pyrene-specific secretory and serum antibody ratios (Ka) in 249 workers of the Kemerovo Power Station, by applying their modified enzyme immunoassay technique. There were 37 (20.5%) and 4 (5.8%) cases with Ka >2 at the preset immunoassay parameters of the 180 and 69 workers of mainline production and auxiliary units, respectively. A Ka value of >2 was found in 35 (21.6%) of the 162 males and only in 6 (6.9%) of the 87 females of the whole sample, in 29 (26.1%) of the 111 smokers and in 12 (8.7%) of the 138 non-smokers. The technique is proposed to study specific immune reactions and exposure to carcinogens primarily in workers of the enterprises processing coal and other types of fuel.
Glushkov
A N
AN
Poleniuk
E G
EG
Mun
S A
SA
Larin
S A
SA
Zinchuk
S F
SF
D000906:Antibodies / Q000097:blood / Q000276:immunology; D001564:Benzo(a)pyrene / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood / Q000276:immunology*; D002273:Carcinogens; D003032:Coal Mining; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000276:immunology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012800:Siberia
D000906:Antibodies; D014408:Biomarkers, Tumor; D002273:Carcinogens; D001564:Benzo(a)pyrene