Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives.
In an attempt to develop potent and selective antitumor agents, a series of liquiritigenin thiosemicarbazone derivatives were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against K562, DU-145, SGC-7901, HCT-116 and Hela cell lines. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward K562 and DU-145 cells. From the structure-activity relationships we may conclude that the introduction of a thiosemicarbazone functional group at the 4-position in the skeleton of liquiritigenin is associated with an increase in cytotoxicity.
Hu
Kun
K
Faculty of Chemistry & Chemical Engineering, Jiangsu Polytechnic University, 1 Gehu Road, Changzhou, Jiangsu 213164, China.
Yang
Ze-Hua
ZH
Pan
Sha-Sha
SS
Xu
Hua-Jin
HJ
Ren
Jie
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004967:Estrogens / Q000378:metabolism; D044950:Flavanones / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004967:Estrogens; D044950:Flavanones; D013882:Thiosemicarbazones; C083152:liquiritigenin