Release of cholecystokinin-like immunoreactivity from slices of dorsal and ventral striatum of rat brain.
Dorsal and ventral striatum may differ in their neuronal organisation and function. In a comparative in vitro study, we investigated the release of cholecystokinin-like immunoreactivity from slices of dorsal and ventral striatum, respectively. Release of immunoreactivity was induced by veratridine. The dopamine D(2)-receptor agonist RU 24926 enhanced, while substance P reduced the release from slices of dorsal striatum. The two agents had no effect on the release of immunoreactivity from slices of ventral striatum. It is concluded that the discrepancy in the modulation of the release of cholecystokinin-like immunoreactivity reflects differences in neuronal organisation in both functionally important areas.
Meyer
D K
DK
Department of Pharmacology, University of Freiberg, Freiburg, Federal Republic of Germany.
Holland
A
A
Conzelmann
U
U