Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones.
The cycloisomerisation of simple keto-alkynes proceeds at room temperature under the mild conditions of gold catalysis. Bicyclic fused and spiro compounds can be obtained by overall 5-exo and 6-exo carbon-carbon bond-forming cyclisations.
Davies
Paul W
PW
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT. p.w.davies@bham.ac.uk
Detty-Mambo
Christelle
C