A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei.
Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior.
García-Moreno
Fernando
F
Instituto Cajal (Consejo Superior de Investigaciones Científicas), Laboratory of Telencephalic Development, Molecular, Cellular and Developmental Neurobiology Department, Madrid, Spain.
Pedraza
María
M
Di Giovannantonio
Luca G
LG
Di Salvio
Michela
M
López-Mascaraque
Laura
L
Simeone
Antonio
A
De Carlos
Juan A
JA
D000679:Amygdala / Q000196:embryology* / Q000502:physiology; D000818:Animals; D002452:Cell Count; D002465:Cell Movement / Q000502:physiology*; D004027:Diencephalon / Q000196:embryology* / Q000502:physiology; D018274:Electroporation; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D007031:Hypothalamus / Q000196:embryology / Q000502:physiology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D034622:RNA Interference; D055153:Stem Cell Niche / Q000196:embryology / Q000502:physiology; D013687:Telencephalon / Q000196:embryology* / Q000502:physiology
D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; C088624:Otp protein, mouse