Obesity and insulin resistance in women with polycystic ovary syndrome.
OBJECTIVE
To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR).


METHODS
ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively.


RESULTS
The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7).


CONCLUSIONS
The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.
Chun-Sen
Hsu
H
Department of Obstetrics and Gynecology, Taipei Medical University, Wan Fang Hospital, Taipei, Taiwan.
Chien-Hua
Wu
W
Wan-Chun
Chiu
C
Ching-Tzu
Lee
L
Chun-Jen
Chang
C
Ming-I
Hsu
H
D000328:Adult; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000503:physiopathology; D007333:Insulin Resistance; D009765:Obesity / Q000503:physiopathology*; D009839:Oligomenorrhea / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult