title: Potential effects of chrysin on MDA-MB-231 cells.
abstract: This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 microM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
authors.affiliation: Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia. banhong86@hotmail.com
authors.forename: Teh Ban
authors.initials: TB
authors.lastname: Hong
authors.forename: Anizah
authors.initials: A
authors.lastname: Rahumatullah
authors.forename: Thaneswary
authors.initials: T
authors.lastname: Yogarajah
authors.forename: Maimunah
authors.initials: M
authors.lastname: Ahmad
authors.forename: Khoo Boon
authors.initials: KB
authors.lastname: Yin
mesh_terms: D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D005419:Flavonoids; D047493:PPAR alpha; D012333:RNA, Messenger; C043561:chrysin