title: A 20-year follow-up of the mesh wallstent in the treatment of detrusor external sphincter dyssynergia in patients with spinal cord injury.
abstract: OBJECTIVE
  To assess the long-term (20 years) effectiveness of the UroLume wallstent(TM) (Pfizer Inc., UK) in the treatment of detrusor external sphincter dyssynergia (DESD) in patients with spinal cord injury (SCI).
  
  
  METHODS
  Twelve patients with quadriplegia secondary to SCI underwent external striated sphincter stenting with the UroLume wallstent in place of sphincterotomy for DESD ≈ 20 years ago. The mean (range) age was 41.8 (26-65) years. Eleven patients had cervical level injury whilst one had a thoracic injury. All the patients were shown to have high-pressure neurogenic detrusor overactivity and DESD with incomplete emptying on preoperative video-cystometrograms (VCMG).
  
  
  RESULTS
  Six of the 12 patients have now been followed-up for a mean (range) of 20 (19-21) years. Of the remaining six, two were lost to follow-up at 1 and 3 years, but both remained free of complications during that time. Two patients developed encrustation causing obstruction, requiring stent removal within 1 year of insertion. Another patient with an adequately functioning stent died 7 years after stent insertion from a chest infection. The twelfth patient developed bladder cancer 14 years after stent insertion and underwent cystectomy with urinary diversion. VCMG follow-up of the six patients showed a significantly sustained reduction of maximum detrusor pressure and duration of detrusor contraction at the 20-year follow-up. Five of these six patients developed bladder neck dyssynergia of varying degrees as shown on VCMG within the first 9 years of follow-up. All were successfully treated with bladder neck incision (BNI) where the last BNI needed was at 12 years. We did not encounter any problem with stent migration, urethral erosion, erectile dysfunction or autonomic dysreflexia.
  
  
  CONCLUSIONS
  Urethral stenting using the UroLume wallstent is effective in the management of DESD in patients with SCI and provides an acceptable long-term (20-year follow-up) alternative to sphincterotomy. The failures manifest within the first few years and can be managed easily with stent removal without any significant problems. Bladder neck dyssynergia was the long-term complication which was treated successfully with BNI. It has no significant interference with erectile function, being reversible, minimally invasive and has a shorter hospital stay.
authors.affiliation: Spinal Cord Injuries Centre, Royal National Orthopaedic Hospital, Stanmore, London, UK. ahmadden@doctors.org.uk
authors.forename: Ahmad
authors.initials: A
authors.lastname: Abdul-Rahman
authors.forename: Soran
authors.initials: S
authors.lastname: Ismail
authors.forename: Rizwan
authors.initials: R
authors.lastname: Hamid
authors.forename: Julian
authors.initials: J
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D001259:Ataxia / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011782:Quadriplegia / Q000150:complications; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*; D015607:Stents; D016896:Treatment Outcome; D001745:Urinary Bladder Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics / Q000502:physiology