title: Drug resistance mutations in HIV-infected patients in the Spanish drug resistance database failing tipranavir and darunavir therapy.
abstract: The presence of resistance mutations in patients failing tipranavir or darunavir was examined at the national drug resistance database of the Spanish AIDS Research Network. Although mutations emerging during tipranavir and darunavir failures differed considerably, cross-resistance was found in up to half of the patients tested. Interestingly, mutation 54L, which is associated with tipranavir hypersusceptibility, was selected in half of the darunavir failures. Thus, resistance testing seems mandatory to ensure the benefit of the sequential use of these drugs.
authors.affiliation: Infectious Diseases Department, Hospital Carlos III, Calle Sinesio Delgado 10, Madrid 28029, Spain. evapoveda@hotmail.com
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
authors.forename: Lourdes
authors.initials: L
authors.lastname: Anta
authors.forename: José Luis
authors.initials: JL
authors.lastname: Blanco
authors.forename: José Luis
authors.initials: JL
authors.lastname: Casado
authors.forename: Félix
authors.initials: F
authors.lastname: Gutiérrez
authors.forename: Federico
authors.initials: F
authors.lastname: García
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Gómez-Sirvent
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Iribarren
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
mesh_terms: D000069454:Darunavir; D016208:Databases, Factual; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D009154:Mutation; D011725:Pyridines / Q000627:therapeutic use*; D011753:Pyrones / Q000627:therapeutic use*; D013030:Spain; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D017320:HIV Protease Inhibitors; D011725:Pyridines; D011753:Pyrones; D013449:Sulfonamides; D000069454:Darunavir; C107201:tipranavir