title: Sebaceous cell carcinoma of the eyelid: a rapidly enlarging lesion with massive xanthogranulomatous inflammation.
abstract: A 76-year-old man presented atypically with a 4-week history of a rapidly enlarging ulcerated nodular lesion of the left upper eyelid that was found to be sebaceous cell carcinoma. Further investigation showed no metastatic disease, and Mohs surgery was performed to resect the tumor. Histopathologic analysis showed features diagnostic of sebaceous cell carcinoma. However, most of the mass consisted of xanthomatous granulomatous inflammatory reaction vastly out of proportion with the tumor burden. The patient was spared from orbital exenteration, and no evidence of recurrence was present 6 months after resection.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin 53705, USA. fhwang@uwhealth.org
authors.forename: Frank S
authors.initials: FS
authors.lastname: Hwang
authors.forename: Aneesh
authors.initials: A
authors.lastname: Neekhra
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Lucarelli
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Warner
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Snow
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Albert
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005142:Eyelid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006099:Granuloma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D015580:Mohs Surgery; D049268:Positron-Emission Tomography; D012626:Sebaceous Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014973:Xanthomatosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery