Science to practice: Can diffusion-weighted MR imaging findings be used as biomarkers to monitor the progression of renal fibrosis?
In an experimental murine model of unilateral ureteral obstruction, Togao et al demonstrated that diffusion-weighted (DW) magnetic resonance (MR) imaging can depict and enable monitoring of abnormal changes in the progression of renal fibrosis; because these microstructural changes are complex and multifactorial, future studies focused on their specificity should be performed before they are applied in clinical trials.
Thoeny
Harriet C
HC
Institute of Diagnostic, Interventional and Pediatric Radiology Inselspital, University of Bern Freiburgstrasse 10, Bern CH-3010, Switzerland. harriet.thoeny@insel.ch
Grenier
Nicolas
N
D000818:Animals; D015415:Biomarkers; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005355:Fibrosis; D007674:Kidney Diseases / Q000473:pathology*; D051379:Mice; D014517:Ureteral Obstruction / Q000473:pathology
D015415:Biomarkers