Monoclonal antibodies directed against the drug haloperidol.
Haloperidol coupled to albumin via the hydroxyl or carbonyl group has been used to obtain two classes of monoclonal anti-haloperidol antibodies. Both classes of monoclonal antibody bind haloperidol with high affinity but whereas one class is highly specific for haloperidol the other class binds other butyrophenones e.g. droperidol, spiperone. Anti-idiotypic antisera have been obtained that inhibit [(3)H]haloperidol binding to the anti-haloperidol antibodies but these do not cross react with the D(2) dopamine receptor.
Juszczak
R
R
Department of Biochemistry, The Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, U.K.
Strange
P G
PG