Corneal complications of intraoperative Mitomycin C in glaucoma surgery.
OBJECTIVE
To report corneal toxicity of Mitomycin C application during filtering glaucoma surgery in two patients.


METHODS
An elderly woman, 81 years of age, developed diffuse corneal epitheliopathy with subepithelial stromal oedema seven weeks after a trabeculectomy with Mitomycin C application. Another patient, a 76-year-old man, first developed a central epithelium defect and stromal oedema in the second postoperative week after a similar procedure. Later the corneal stroma melted, what resulted in perforation in the second postoperative month.


RESULTS
Intraoperative Mitomycin C application during trabeculectomy induced serious corneal complications several weeks after the surgery.


CONCLUSIONS
Although infrequent, serious corneal complications may arise following the intraoperative use of Mitomycin C in filtering surgery for glaucoma. The possible contributing factors to the development of the corneal toxicity will be discussed.
Coppens
G
G
UZ Leuven.
Maudgal
P
P
D000368:Aged; D000369:Aged, 80 and over; D000477:Alkylating Agents / Q000009:adverse effects; D000933:Antifibrinolytic Agents / Q000009:adverse effects; D003316:Corneal Diseases / Q000139:chemically induced*; D019573:Epithelium, Corneal / Q000187:drug effects*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007430:Intraoperative Care / Q000009:adverse effects*; D008297:Male; D016685:Mitomycin / Q000009:adverse effects*
D000477:Alkylating Agents; D000933:Antifibrinolytic Agents; D016685:Mitomycin