title: Association of the +874 T/A interferon gamma polymorphism with infections in sickle cell disease.
abstract: Infectious complications are a leading cause of morbidity and mortality in patients with sickle cell disease. Several mechanisms are supposed to contribute to this susceptibility. The exact reasons for the susceptibility of sickle cell patients to infection are not clear and are still a matter of debate. Interferon gamma (IFNgamma) is a key cytokine involved mainly in the defence against intracellular pathogens. We investigated a possible association of an IFNgamma +874 T/A polymorphism and infectious complications in sickle cell patients. Seventy-two sickle cell patients were typed for +874 T/A IFNgamma polymorphism. Genotype frequencies were different between cases and controls. Indeed, the T allele frequency was significantly higher in patients with infections than in patients without infections (P = 0.014). Our results suggest that the +874 T/A IFNgamma polymorphism is associated with infectious complications in sickle cell patients. T allele could be involved in infections in sickle cell patients.
authors.affiliation: Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: M O
authors.initials: MO
authors.lastname: Joannes
authors.forename: G
authors.initials: G
authors.lastname: Loko
authors.forename: J
authors.initials: J
authors.lastname: Deloumeaux
authors.forename: R
authors.initials: R
authors.lastname: Chout
authors.forename: T
authors.initials: T
authors.lastname: Marianne-Pepin
mesh_terms: D000328:Adult; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D001424:Bacterial Infections / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D015897:Comorbidity; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008395:Martinique / Q000453:epidemiology; D008875:Middle Aged; D010019:Osteomyelitis / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology; D020641:Polymorphism, Single Nucleotide; D018805:Sepsis / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult
chemical_list: D007371:Interferon-gamma