Serum fibroblast growth factor 21 levels in polycystic ovary syndrome.
OBJECTIVE
This study was designed to measure serum fibroblast growth factor 21 (FGF21) levels in patients with polycystic ovary syndrome (PCOS) and healthy subjects.


METHODS
A total of 37 women were evaluated. Serum levels FGF21, glucose, lipid profile, hormones (follicle-stimulating hormone, luteinising hormone, oestradiol, testosterone, thyroid stimulating hormone, prolactin and insulin) were determined in 24 PCOS (15 subjects of PCOS BMI < 25 kg/m2, 9 subjects of PCOS BMI ≥ kg/m2) and 13 control group (BMI < 25 kg/m2).


RESULTS
Serum FGF21 levels were higher in the PCOS group [99.5 (173.7) pg/ml] than in the control group [52.0 (88.0) pg/ml]. LH and T are significantly higher in PCOS cases (respectively; p < 0.05, p < 0.01). A positive correlation was found between FGF21 and luteinising hormone and testosterone (respectively; r = 0.43 p = 0.007, r = 0.38, p = 0.02). Multivariate discriminant analysis showed that BMI, triglyceride, HOMA-IR, fasting glucose with rise of FGF21 were found significant in PCOS.


CONCLUSIONS
Our study indicates that FGF21 in cases with PCOS exhibit an increase along with the increase of BMI and also has a positive correlation with LH and T. Further studies are required to clarify the aetiology and effects of FGF21 in women with PCOS.
Gorar
Suheyla
S
Ankara Training and Research Hospital, Endocrinology and Metabolic Disease Department, Ankara, Turkey. sgorar@hotmail.com
Culha
Cavit
C
Uc
Ziynet Alphan
ZA
Dellal
Fatma Dilek
FD
Serter
Rustu
R
Aral
Sema
S
Aral
Yalcin
Y
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016002:Discriminant Analysis; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D014280:Triglycerides; C414620:fibroblast growth factor 21; D013739:Testosterone; D005346:Fibroblast Growth Factors; D007986:Luteinizing Hormone