Single IB domain (SIBD) protein from Litopenaeus vannamei, a novel member for the IGFBP family.
Several clones encoding for a peptide similar to insulin-like growth factor protein binding (IGFBP) were found in a Litopenaeus vannamei hemocytes cDNA library. Although IGFBP is constituted by two well defined domains (IB and tyroglobulin) joint by a flexible region; the shrimp transcript encoding only for the IB domain as confirmed by Northern analysis. The expression of this, single IB domain (SIBD)-containing protein is modified by bacteria inoculation suggesting a role in immune response. In addition, shrimp SIBD protein seems to be the common ancestor for the IGFBP superfamily.
Castellanos
Mónica
M
Centro de Investigación en Alimentación y Desarrollo (CIAD). Marine Biotechnology Lab. PO Box 1735, Hermosillo, Son, 83000, Mexico.
Jiménez-Vega
Florinda
F
Vargas-Albores
Francisco
F