Regional heterogeneity within the nucleus accumbens concerning the effects of dopaminergic agents on the content of cholecystokinin.
In the anterior nucleus accumbens of the rat, the high dose of apomorphine (5 mg/kg i.p.) increased and r-butyrolactone decreased cholecystokinin octapeptide-like immunoreactivity, but the low dose of apomorphine (0.02 mg/kg i.p.) did not induce any change. In contrast, all administrations increased immunoreactivity in the posteromedial nucleus accumbens. These results suggests that the different responses of cholecystokinin may reflect the heterogeneity in neuronal organization within the nucleus accumbens.
Yoshikawa
T
T
Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan.
Fukamauchi
F
F
Shibuya
H
H
Takahashi
R
R