Oxidative stress, molecular inflammation and sarcopenia.
Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. The purpose of this review is to discuss some of the major signaling pathways that are activated or inactivated during the oxidative stress and molecular inflammation seen in aged skeletal muscle. Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed.
Meng
Si-Jin
SJ
Institution of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China. msijin@wipe.edu.cn
Yu
Long-Jiang
LJ
D031204:Caloric Restriction; D015444:Exercise; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism; D018384:Oxidative Stress; D011494:Protein Kinases / Q000378:metabolism; D055948:Sarcopenia / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D015398:Signal Transduction
D011494:Protein Kinases