[Dose-effect relationship of irbsartan with the changes in the renal tissue structure in diabetic rats].
OBJECTIVE
To investigate the relationship between the dosage of irbesartan and the renal tissue structure in diabetic rats.


METHODS
Male Wistar rats was given a single intraperitoneal dose (mg/kg) of streptozotocin to induce diabetes. The diabetic rats were randomized into 4 groups and received 4 weeks later 25 mg/kg (n=9), 50 mg/kg (n=9), 200 mg/kg (n=9) irbesartan intragastrically, or equal volume of water (model group, n=11) on a daily basis. Seven normal rats receiving with equal volume of water served as the normal control. All the rats were sacrificed after 8 weeks and the 24-hour albumin excretion, renal mass index and the volume of the glomerulus were measured.


RESULTS
The 24-hour albumin excretion, renal mass index and volume of the glomerulus in the 3 irbesartan groups were significantly decreased as compare with those in the model group; the reductions in 50 and 200 mg/kg irbesartan groups were significant greater than those in 25 mg/kg irbesartan group.


CONCLUSIONS
Irbesartan can decrease the 24-hour urinary albumin excretion and relive glomerulopathy in diabetic rats. Within a certain dose range, irbesartan produces a dose-dependent protective effect on the renal structures in the diabetic rats.
Tang
Jie-long
JL
Department of Endocronology and Metablic Disease, Nanfang Hospital, Southern Medical University, Guanzhou 510515, China. long2001@163.com
Shen
Jie
J
Liu
Shuai
S
Fan
Yan-fei
YF
Xie
Cui-hua
CH
D000818:Animals; D001713:Biphenyl Compounds / Q000009:adverse effects / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D000077405:Irbesartan; D007668:Kidney / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013777:Tetrazoles / Q000009:adverse effects / Q000494:pharmacology*
D001713:Biphenyl Compounds; D013777:Tetrazoles; D000077405:Irbesartan