title: [The expression of interleukin-17 in blood and nasal tissue of patients with allergic rhinltis and nasal polyps].
abstract: OBJECTIVE
  To study the expression of IL-17 in blood and nasal tissue of allergic rhinitis and nasal polyps, and to investigate the possible mechanism of IL-17 in the progress of allergic rhinitis and nasal polyps.
  
  
  METHODS
  There were 41 patients enrolled, including the patients with allergic rhinitis, nasal polyps and deviated nasal septum. The blood and nasal mucosa tissue or nasal polyps were collected in all the patients. The expression of IL-17 was measured by the methods of ELISA and immunohistochemisty, and the number of eosinophils and IL-17 positive cells was measured.
  
  
  RESULTS
  The IL-17 expression of nasal polyps was significantly elevated in the blood and nasal tissue, which was obviously correlated with the number of eosinophils infiltrated in nasal tissue. However, for the patients with allergic rhinitis, there was only apparent expression of IL-17 in nasal mucosa.
  
  
  CONCLUSIONS
  IL-17 plays an important role in the development of nasal polyps, but for allergic rhinitis, it needs further study as an potential important aspect of the pathogenesis.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jin-tao
authors.initials: JT
authors.lastname: Du
authors.forename: Luo
authors.initials: L
authors.lastname: Ba
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Shang
authors.forename: Ya-feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Da-peng
authors.initials: DP
authors.lastname: Wei
authors.forename: Hui-min
authors.initials: HM
authors.lastname: An
mesh_terms: D000293:Adolescent; D000328:Adult; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D055815:Young Adult
chemical_list: D020381:Interleukin-17