title: [Meta analysis on effect of local application of chlorhexidine with scaling and root planing].
abstract: OBJECTIVE
  Meta analysis was used to assess the effect of local drug delivery system of chlorhexidine (CHX) as an adjunct to scaling and root planing(SRP) versus SRP alone in patients with chronic periodontitis.
  
  
  METHODS
  The selected studies of randomized controlled trials(RCTs) were pooled from six major electronic database up to May,2009 as CHX plus SRP versus SRP with at least 3 months of follow-up. Several English full texts were hand searched. Outcome measures were probing depth(PD) reduction and clinical attachment level (CAL)gain.
  
  
  RESULTS
  Seven studies that met inclusion criteria were entered into the Meta analysis. A significant mean reduction of PD in patients with CHX plus SRP was observed, but there were no significant difference in CAL between the two treatment groups.
  
  
  CONCLUSIONS
  Chlorhexidine as an adjunct to SRP could reduce probing depth in the treatment of chronic periodontitis. Supported by Research Project of Education Bureau of Liaoning Province(Grant No.20061021).
authors.affiliation: Department of Periodontology, School of Stomatology,China Medical University, Shenyang 110002, Liaoning Province, China. linli_74k@yahoo.com
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Li
authors.forename: Li-yun
authors.initials: LY
authors.lastname: Liang
authors.forename: Xiao-jia
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Pan
mesh_terms: D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine; D055113:Chronic Periodontitis; D012534:Dental Scaling; D006801:Humans; D010512:Periodontal Index; D010518:Periodontitis; D016745:Root Planing
chemical_list: D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine