title: Apoptosis of Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma revisited.
abstract: We scrutinized the role of apoptosis of the Hodgkin-Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) and critically reviewed its features in the light of conflicting evidence. In this study, we found that tumor cells in this neoplasm showed inhibition of apoptosis in 55% of the 217 cHL cases only. It is also suggested that the two factors considered responsible for apoptosis inhibition in HRS cells, nuclear factor-kappaB and the latent membrane protein-1 of the Epstein-Barr virus, do not correlate with apoptosis inhibition, in contrast with the findings in the consensual pathogenetic scheme. The most significant association of HRS cell apoptosis was with p53, the negative expression of which related with a high apoptotic index (p = 0.001). These findings support our contention that the role of apoptosis in the HRS cells of Hodgkin lymphoma has not been completely elucidated and is at variance with that in the consensus.
authors.affiliation: Department of Pathology, Soroka University Medical Center, Beer-Sheva, Israel. benaroch@bgu.ac.il
authors.forename: Daniel
authors.initials: D
authors.lastname: Benharroch
authors.forename: Inbal
authors.initials: I
authors.lastname: Einav
authors.forename: Alexandra
authors.initials: A
authors.lastname: Feldman
authors.forename: Amalia
authors.initials: A
authors.lastname: Levy
authors.forename: Samuel
authors.initials: S
authors.lastname: Ariad
authors.forename: Jacob
authors.initials: J
authors.lastname: Gopas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D004854:Herpesvirus 4, Human / Q000378:metabolism / Q000472:pathogenicity; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D014763:Viral Matrix Proteins / Q000378:metabolism; D055815:Young Adult
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D016328:NF-kappa B; D014763:Viral Matrix Proteins