The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study.
BACKGROUND
Retrospective accounts suggest that therapeutic doses of paracetamol can produce severe hepatic injury in patients with putative high-risk conditions, including alcoholism and infectious hepatitis. Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also have compromised liver defences from depressed hepatic glutathione.


OBJECTIVE
To determine the effect of paracetamol on serum liver tests of newly abstinent subjects who abuse alcohol, including subjects with hepatitis C infection.


METHODS
A randomized, double-blind, placebo-controlled study. Adult alcohol abusers with a current drinking episode longer than 7 days received either placebo or paracetamol 4 g/day for 5 days.


RESULTS
Of 142 subjects enrolled, 74 received paracetamol and 68 received placebo. Mean ALT activity during treatment increased from 48 to 62 IU/L in the paracetamol group and from 47 to 49 IU/L in the placebo group. Maximum ALT was 238 and 249 IU/L in the paracetamol and control groups respectively. The INR remained unchanged and serum bilirubin decreased in both groups. Subgroup analyses for subjects with alcoholic hepatitis, hepatitis C virus antibody and other subgroups showed no statistical difference between groups.


CONCLUSIONS
Administration of paracetamol 4 g/day appears safe in newly abstinent patients who abuse alcohol.
Dart
R C
RC
Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO 80204, USA. Richard.Dart@rmpdc.org
Green
J L
JL
Kuffner
E K
EK
Heard
K
K
Sproule
B
B
Brands
B
B
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology; D006519:Hepatitis, Alcoholic / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D005978:Glutathione