title: Monoclonal anti-torpedo receptor antibodies used to study antibody heterogeneity in myasthenic sera.
abstract: Monoclonal antibodies against Torpedo acetylcholine receptor were used to define the binding regions of cross-reacting, anti-receptor antibodies from sera of myasthenic patients. Cross-reacting antibodies were directed mainly against the toxin-binding region of the receptor and a region remote from the acetylcholine-binding site. Few patients had antibodies against the acetylcholine-binding site region. The monoclonal antibodies provide probes for defining the heterogeneity of anti-receptor antibodies in myasthenic sera.
authors.affiliation: Dept. of Biochemistry, University of Geneva, Geneva, Switzerland.
authors.forename: R W
authors.initials: RW
authors.lastname: James
authors.forename: A K
authors.initials: AK
authors.lastname: Lefvert
authors.forename: C
authors.initials: C
authors.lastname: Alliod
authors.forename: B W
authors.initials: BW
authors.lastname: Fulpius