Development and validation of a multiresidue method for the determination of neonicotinoid and macrocyclic lactone pesticide residues in milk, fruits, and vegetables by ultra-performance liquid chromatography/MS/MS.
A multiresidue method was developed and validated for the determination of 13 neonicotinoid pesticides and metabolites, and nine macrocyclic lactone pesticides and veterinary drugs using SPE and ultra-performance liquid chromatography/MS/MS. The method was validated in milk, orange, spinach, apple, plum, watermelon, green bean, zucchini, broccoli, strawberry, grape, and tomato by analyzing replicates of residue-free control samples fortified with a mixture of 22 target analytes at three concentration levels. The recoveries of the analytes from the fortified matrixes were mostly within 70-120%, except for some of the neonicotinoid metabolites. The LOD values varied by analyte and matrix and ranged between 0.001-2 ng/g. The developed method was successful in combining two widely different classes of compounds into a single analysis.
Kamel
Alaa
A
Qian
Yaorong
Y
Kolbe
Elizabeth
E
Stafford
Charles
C
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005506:Food Contamination / Q000032:analysis; D005638:Fruit; D007783:Lactones / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods; D008892:Milk; D008956:Models, Chemical; D008970:Molecular Weight; D010573:Pesticide Residues / Q000032:analysis*; D010575:Pesticides / Q000032:analysis; D015203:Reproducibility of Results; D014675:Vegetables
D007783:Lactones; D010573:Pesticide Residues; D010575:Pesticides