title: Premalignant epithelial disorders of the vulva: squamous vulvar intraepithelial neoplasia, vulvar Paget's disease and melanoma in situ.
abstract: No standard screening programs exist to detect vulvar carcinoma or its precursor lesions, and therefore gynecologists, dermatologists and other healthcare providers in this field should be aware of the clinical features, behavior and management of the different existing premalignant vulvar lesions, squamous vulvar intraepithelial neoplasia (VIN), vulvar Paget's disease and melanoma in situ. In 2004, a new classification for squamous VIN was introduced by the International Society for the Study of Vulvar Disease, subdividing squamous VIN into the HPV-related usual type, and into differentiated type, which is associated with lichen sclerosus. This review describes the relevant aspects of squamous VIN, vulvar Paget's disease and melanoma in situ, its epidemiological characteristics, diagnosis, management and malignant potential.
authors.affiliation: Departments of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands. a.terlou@erasmusmc.nl
authors.forename: Annelinde
authors.initials: A
authors.lastname: Terlou
authors.forename: Leen J
authors.initials: LJ
authors.lastname: Blok
authors.forename: Theo J M
authors.initials: TJ
authors.lastname: Helmerhorst
authors.forename: Marc
authors.initials: M
authors.lastname: van Beurden
mesh_terms: D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D010145:Paget Disease, Extramammary / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy