title: Membrane neovascularization and drainage of subdural hematoma in a rat model.
abstract: Studies on the pathophysiology of subdural hematomas (SDH) have been primarily focused on the acute phase and associated cortical injury, whereas the course of hematoma absorption remains poorly understood. Using a rat model of SDH, we have specifically investigated the correlation between neovascularization of membrane and the rate of hematoma absorption. Using improved surgical techniques, we have reduced surgery-related injury and increased the rate of generating successful SDH to 71.4%. With this model, we demonstrate that hematoma absorption was slow in the first 4 days and accelerated thereafter. The absorption rate and recovery of sensorimotor deficits were closely associated with neovascularization in the neomembrane characterized by the formation of arachnoid granulation-like structures at the interface between the hematoma and encapsulating neomembrane. Our data suggest that neovascularization in the neomembrane plays a key role in hematoma absorption and neuronal recovery. Furthermore, measures to enhance neovascularization could have therapeutic potentials.
authors.affiliation: Department of Neurosurgery, Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Rongcai
authors.initials: R
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Jing-Fei
authors.initials: JF
authors.lastname: Dong
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005552:Forelimb / Q000502:physiology; D006408:Hematoma, Subdural / Q000473:pathology* / Q000523:psychology; D007150:Immunohistochemistry; D008297:Male; D008566:Membranes / Q000473:pathology; D046529:Microscopy, Electron, Transmission; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function