title: Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi.
abstract: In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC(50) values of 3.17 and 3.21 microM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
authors.affiliation: State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China. jianyez2003@yahoo.com.cn
authors.forename: Jian-ye
authors.initials: JY
authors.lastname: Zhang
authors.forename: Li-yang
authors.initials: LY
authors.lastname: Tao
authors.forename: Yong-ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Chen
authors.forename: Yan-jun
authors.initials: YJ
authors.lastname: Mi
authors.forename: Li-sheng
authors.initials: LS
authors.lastname: Zheng
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: She
authors.forename: Yong-cheng
authors.initials: YC
authors.lastname: Lin
authors.forename: Kenneth Kin Wah
authors.initials: KK
authors.lastname: To
authors.forename: Li-wu
authors.initials: LW
authors.lastname: Fu
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D043982:Rhizophoraceae / Q000382:microbiology*; D013329:Structure-Activity Relationship
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents