Is fibrinogen the answer to coagulopathy after massive transfusions?
Coagulopathy is a major cause of morbidity and mortality in patients who have suffered severe hemorrhage and received massive transfusions. Administration of a fibrinogen concentrate along with red blood cells can quickly restore hemostasis in a clinically relevant animal model.
Tisherman
Samuel A
SA
Departments of Critical Care Medicine and Surgery, University of Pittsburgh, 638 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. tishermansa@upmc.edu
D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D005340:Fibrinogen / Q000494:pharmacology / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D023421:Models, Animal; D065227:Transfusion Reaction; D016896:Treatment Outcome
D005340:Fibrinogen