title: Adjunctive micronutrient supplementation for pulmonary tuberculosis.
abstract: OBJECTIVE
  To assess the effect of micronutrient supplementation on tuberculosis (TB) patient outcomes.
  
  
  METHODS
  The randomized, double-blinded, placebo-controlled study was conducted in pulmonary TB patients undergoing directly observed treatment short course/ tratamiento acortado estrictamente supervisado (TAES/ DOTS) at IMSS in Ciudad Juarez, Chihuahua, Mexico, who were recruited during August 2005-July 2006. Consecutive patients received zinc and vitamin A supplements or matched placebo for four months. Dietary intake, blood zinc and vitamin A, immune response (IFN-gamma,TNF-alpha, and IL-10 mRNA), and sputum smear conversion were measured.
  
  
  RESULTS
  The proportion of micronutrient compared to placebo group subjects with a negative sputum smear by month 3 was significantly increased (p= 0.03). This occurred subsequent to increased TNF-alpha and IFN-gamma and decreased IL-10 observed at month 2. Micronutrient supplementation appeared to accelerate the beneficial therapeutic effect of chemotherapy.
  
  
  CONCLUSIONS
  The earlier elimination of bacilli from sputum was associated with improved zinc status and Th1 immune response. The therapeutic effect of vitamin A was less evident.
authors.affiliation: Department of Health Promotion/MPH Program, College of Health Sciences, University of Texas, El Paso, TX 79902-0581, USA. rxarmijos@utep.edu
authors.forename: Rodrigo X
authors.initials: RX
authors.lastname: Armijos
authors.forename: M Margaret
authors.initials: MM
authors.lastname: Weigel
authors.forename: Rocío
authors.initials: R
authors.lastname: Chacon
authors.forename: Luis
authors.initials: L
authors.lastname: Flores
authors.forename: Armando
authors.initials: A
authors.lastname: Campos
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage*; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology*; D014801:Vitamin A / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D018977:Micronutrients; D014815:Vitamins; D014801:Vitamin A; D015032:Zinc