Enhanced bioavailability of eicosapentaenoic acid from fish oil after encapsulation within plant spore exines as microcapsules.
Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC(0-24)). The mean AUC(0-24) of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.
Wakil
Ammar
A
Hull Royal Infirmary, Michael White Diabetes Centre, 220-236 Anlaby Road, HU3 2RW, Hull, UK. ammar.wakil@gmail.com
Mackenzie
Grahame
G
Diego-Taboada
Alberto
A
Bell
J Gordon
JG
Atkin
Stephen L
SL
D001682:Biological Availability; D002214:Capsules; D015118:Eicosapentaenoic Acid / Q000493:pharmacokinetics*; D005227:Fatty Acids / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D032502:Lycopodium / Q000737:chemistry / Q000378:metabolism
D002214:Capsules; D005227:Fatty Acids; D005395:Fish Oils; D015118:Eicosapentaenoic Acid