title: Frequency of occult high-grade squamous intraepithelial neoplasia and invasive cancer within anal condylomata in men who have sex with men.
abstract: Human papillomavirus causes anal condylomata, high-grade anal intraepithelial neoplasia, and anal squamous cell cancer. We found high-grade intraepithelial neoplasia or squamous cell cancer in 75 (47%) of 159 HIV-seropositive men who have sex with men (MSM) and in 42 (26%) of 160 HIV-seronegative MSM with anal condylomata meriting surgery (P<.001, determined by use of the chi(2) test). Anal condylomata in MSM often harbor high-grade intraepithelial neoplasia and squamous cell cancer.
authors.affiliation: Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel College of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Hans P
authors.initials: HP
authors.lastname: Schlecht
authors.forename: Dana K
authors.initials: DK
authors.lastname: Fugelso
authors.forename: Ryan K
authors.initials: RK
authors.lastname: Murphy
authors.forename: Katiri T
authors.initials: KT
authors.lastname: Wagner
authors.forename: John P
authors.initials: JP
authors.lastname: Doweiko
authors.forename: Joann
authors.initials: J
authors.lastname: Proper
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Dezube
authors.forename: Lori A
authors.initials: LA
authors.lastname: Panther
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus; D001004:Anus Diseases / Q000150:complications* / Q000601:surgery / Q000821:virology; D001005:Anus Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D003218:Condylomata Acuminata / Q000150:complications* / Q000601:surgery / Q000821:virology; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000150:complications*; D012189:Retrospective Studies; D055815:Young Adult