title: Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum.
abstract: In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, the selective D-2 agonist bromocriptine inhibited by the same extent and with the same potency AC in controls and reserpinized striata. In addition, the density of both D-1 and D-2 receptors, as measured in binding studies with the selective D-1 antagonist [(3)H]SCH 23390 and with [(3)H]spiroperidol respectively, was not affected by the treatment. These results suggest that acute reserpine administration induces a selective up-regulation of the transduction mechanisms associated with D-1 receptors, without changing the functional activity of D-2 receptors.
authors.affiliation: Institute of Pharmacology and Experimental Therapeutics, School of Medicine, University of Brescia, Nerviano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Liberini
authors.forename: E
authors.initials: E
authors.lastname: Nisoli
authors.forename: C
authors.initials: C
authors.lastname: Missale
authors.forename: M
authors.initials: M
authors.lastname: Memo
authors.forename: M
authors.initials: M
authors.lastname: Buonamici
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: P F
authors.initials: PF
authors.lastname: Spano