title: Massive immature teratoma in a neonate.
abstract: Teratomas are embryonal tumours composed of diverse tissues from three germinal layers with variable levels of maturity. The authors report a female patient with a large immature epignathus. Prenatal diagnosis permitted a caesarean section and tracheotomy to be planned under ex utero intrapartum treatment for airway obstruction. The tumour was successfully controlled, even though it was impossible to distinguish from normal tissue because it lacked a pedicle and capsule, using multidisciplinary therapy, including a series of surgical treatments and adjuvant chemotherapy. This case suggested that the level of serum alpha fetoprotein might be a useful indicator after surgery. At present, after 4 years, no regrowth has been observed and the patient has no problems with respiration or swallowing.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Toyohashi Municipal Hospital, 50 Hachiken Nishi, Aotake-Cho, Toyohashi, Aichi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sumiyoshi
authors.forename: J
authors.initials: J
authors.lastname: Machida
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Fukano
authors.forename: K
authors.initials: K
authors.lastname: Shimozato
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: A
authors.initials: A
authors.lastname: Kaetsu
mesh_terms: D002585:Cesarean Section; D017024:Chemotherapy, Adjuvant; D005260:Female; D005333:Fetus / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D009062:Mouth Neoplasms / Q000151:congenital* / Q000601:surgery; D020360:Neoadjuvant Therapy; D018365:Neoplasm, Residual / Q000473:pathology; D009669:Nose Neoplasms / Q000151:congenital* / Q000601:surgery; D011247:Pregnancy; D011296:Prenatal Diagnosis; D019292:Skull Base Neoplasms / Q000473:pathology; D013100:Sphenoid Bone / Q000473:pathology; D013724:Teratoma / Q000151:congenital* / Q000601:surgery; D055815:Young Adult