title: Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and "click" linker.
abstract: A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: John E
authors.initials: JE
authors.lastname: Moses