Linear free-energy relationship analysis of a catalytic desymmetrization reaction of a diarylmethane-bis(phenol).
Linear free-energy relationships have been found for enantioselectivity and various steric parameters in an enantioselective desymmetrization of symmetrical bis(phenol) substrates. The potential origin of this observation and the role of different steric parameters are discussed.
Gustafson
Jeffrey L
JL
Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, USA.
Sigman
Matthew S
MS
Miller
Scott J
SJ
D002384:Catalysis; D018499:Linear Energy Transfer; D015394:Molecular Structure; D019800:Phenol / Q000737:chemistry*; D013237:Stereoisomerism
D019800:Phenol