Recent developments on chiral P,S-type ligands and their applications in asymmetric catalysis.
This feature article illustrates new concepts and approaches for designing new P,S-mixed donor chelating ligands based on three major types of chiral skeleton, the central, axial and planar chirality. The versatility in structural modification is highlighted. It offers an effective pathway to access scientifically useful chiral ligands of diverse electronic and steric properties for optimization in various catalytic enantioselective transformations. In this article, the applications of these optically active ligands in a variety of asymmetric catalytic reactions will be discussed with reference to updated literature findings as well as the author's original research.
Lam
Fuk Loi
FL
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Kwong
Fuk Yee
FY
Chan
Albert S C
AS
D002384:Catalysis; D002614:Chelating Agents / Q000737:chemistry; D007495:Iridium / Q000737:chemistry; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D002614:Chelating Agents; D008024:Ligands; D007495:Iridium; D010165:Palladium