Rickettsia pays the piper; new actors and some bad actin'.
Pathogens such as Listeria have been used to define host factors regulating actin dynamics, including the Arp2/3 complex. In this issue of Cell Host & Microbe, Serio et al. (2010) use Rickettsia to identify a new complex, based on profilin, which regulates actin dynamics in normal cells and which may be exploitable by diverse pathogens.
Kalman
Daniel
D
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA. dkalman@emory.edu
Ono
Shoichiro
S