title: Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells.
authors.forename: T
authors.initials: T
authors.lastname: Lasho
authors.forename: A
authors.initials: A
authors.lastname: Tefferi
authors.forename: A
authors.initials: A
authors.lastname: Pardanani
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D000069439:Dasatinib; D004357:Drug Synergism; D006801:Humans; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008407:Mast Cells / Q000187:drug effects*; D009154:Mutation / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D050799:STAT5 Transcription Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology; D000096926:Benzenesulfonamides
chemical_list: D000069439:Dasatinib; D053614:Janus Kinase 2; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases; D019009:Proto-Oncogene Proteins c-kit; D011743:Pyrimidines; D011759:Pyrrolidines; D050799:STAT5 Transcription Factor; D013449:Sulfonamides; D013844:Thiazoles; C528327:fedratinib; D000096926:Benzenesulfonamides; C507924:JAK2 protein, human