title: Disseminated mast cell tumor infiltrating the sphenoid bone and causing blindness in a dog.
abstract: Mast cell tumors are found in most organs and tissues with variable biologic behavior in dogs. This case illustrates the clinical and magnetic resonance imaging (MRI) findings in a dog with disseminated mast cell tumor infiltrating the sphenoid bones. A 6-year-old male neutered Greyhound presented with a 3-day history of acute onset of blindness. General physical examination was normal. Neurological examination revealed mildly disorientated mental status, absent menace response in both eyes, bilaterally decreased vestibulo-oculocephalic reflexes and absent direct and consensual pupillary light reflex in both eyes. An electroretinogram indicated normal retinal function in both eyes. A lesion involving the middle and rostral cranial fossa was suspected. Hematology and serum biochemistry were normal except decreased urea (1.2 mmol/L). MRI of the head revealed heterogeneous signal intensity of the sphenoid bones on T2-weighted images and loss of their normal internal architecture. Cerebrospinal fluid analysis was normal. Abdominal ultrasound revealed hepatosplenomegaly and mesenteric lymphadenopathy. Fine needle aspirates were taken from the jejunal lymph nodes and the spleen. Results were consistent with disseminated mast cell tumor. The owner declined any treatment and the dog was euthanatized. Postmortem examination confirmed disseminated mast cell tumor affecting multiple organs, including the sphenoid bones. To our knowledge, this is the first case describing MRI features of disseminated mast cell tumor affecting the sphenoid bones and causing acute onset of blindness in a dog.
authors.affiliation: Centre for Small Animal Studies, Animal Health Trust, Newmarket, UK. elsa.beltran@aht.org.uk
authors.forename: Elsa
authors.initials: E
authors.lastname: Beltran
authors.forename: Alberta
authors.initials: A
authors.lastname: de Stefani
authors.forename: Jennifer
authors.initials: J
authors.lastname: Stewart
authors.forename: Luisa
authors.initials: L
authors.lastname: De Risio
authors.forename: Victoria
authors.initials: V
authors.lastname: Johnson
mesh_terms: D000818:Animals; D001766:Blindness / Q000209:etiology / Q000662:veterinary*; D001859:Bone Neoplasms / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D008297:Male; D034801:Mastocytoma / Q000150:complications / Q000662:veterinary*; D013100:Sphenoid Bone / Q000473:pathology*