title: Synthesis and molecular modeling studies of 3-chloro-4-substituted-1-(8-hydroxy-quinolin-5-yl)-azetidin-2-ones as novel anti-filarial agents.
abstract: A series of 3-chloro-4-substituted-1-(8-hydroxy-quinolin-5-yl)-azetidin-2-ones were synthesized and evaluated for their in vitro anti-filarial activity. To pre-assess the anti-filarial behavior of synthesized compounds (V(a-f)) on a structural basis, automated docking studies were carried out with Molecular Design Suite (MDS v 3.5) into the active site of glutathione-S-transferase (GST) enzyme; scoring functions of these compounds at the active site of the GST enzyme were used for correlation with observed activity. Compounds V(e) and V(f) have shown good affinity for receptor GST, as well as in vitro anti-filarial potency.
authors.affiliation: Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Dhamangaon, Dist-Nasik, MS, India. santosh_chhajed@rediffmail.com
authors.forename: Santosh S
authors.initials: SS
authors.lastname: Chhajed
authors.forename: Puranik
authors.initials: P
authors.lastname: Manisha
authors.forename: Virupaksha A
authors.initials: VA
authors.lastname: Bastikar
authors.forename: Haldar
authors.initials: H
authors.lastname: Animeshchandra
authors.forename: V N
authors.initials: VN
authors.lastname: Ingle
authors.forename: Chandrashekhar D
authors.initials: CD
authors.lastname: Upasani
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Wazalwar
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001384:Azetidines; D003198:Computer Simulation; D005368:Filariasis / Q000188:drug therapy; D005370:Filarioidea / Q000187:drug effects; D005982:Glutathione Transferase / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D001384:Azetidines; D005982:Glutathione Transferase