title: Catalytic enantioselective aldol additions of alpha-isothiocyanato imides to alpha-ketoesters.
abstract: A readily available bifunctional thiourea catalyst promotes aldol additions of alpha-isothiocyanato imides to alpha-ketoesters under mild reaction conditions to form beta-hydroxy-alpha-amino acid derivatives with high levels of enantioselectivity.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Vecchione
authors.forename: Le
authors.initials: L
authors.lastname: Li
authors.forename: Daniel
authors.initials: D
authors.lastname: Seidel
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D004952:Esters / Q000737:chemistry*; D007094:Imides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D004952:Esters; D007094:Imides; D007659:Ketones; D013890:Thiourea