Approximating stochastic biochemical processes with Wasserstein pseudometrics.
Modelling stochastic processes inside the cell is difficult due to the size and complexity of the processes being investigated. As a result, new approaches are needed to address the problems of model reduction, parameter estimation, model comparison and model invalidation. Here, the authors propose addressing these problems by using Wasserstein pseudometrics to quantify the differences between processes. The method the authors propose is applicable to any bounded continuous-time stochastic process and pseudometrics between processes are defined only in terms of the available outputs. Algorithms for approximating Wasserstein pseudometrics are developed from experimental or simulation data and demonstrate how to optimise parameter values to minimise the pseudometrics. The approach is illustrated with studies of a stochastic toggle switch and of stochastic gene expression in E. coli.
Thorsley
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Department of Electrical Engineering, University of Washington, Department of Electrical Engineering, Seattle, USA. thorsley@u.washington.edu
Klavins
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D003198:Computer Simulation; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D008954:Models, Biological; D015233:Models, Statistical; D015398:Signal Transduction / Q000502:physiology*; D013269:Stochastic Processes
D029968:Escherichia coli Proteins