Retinal hemorrhages as a presenting sign in an adolescent patient with hepatosplenic gamma-delta T-cell lymphoma.
Hepatosplenic gamma-delta T-cell lymphoma is a very rare, aggressive form of peripheral lymphoma first recognized in 1990. Patients often present with organomegaly, anemia, adenopathy, and B symptoms. Rarely in the literature is a pediatric patient described with this subtype of peripheral T-cell lymphoma. Also, retinal hemorrhages have never been described as a presenting symptom of hepatosplenic gamma-delta T-cell lymphoma. We describe an adolescent patient with hepatosplenic gamma-delta T-cell lymphoma who presented with retinal hemorrhages, massive splenomegaly, bone marrow involvement, and B symptoms.
Edwards
Jeremy
J
Department of Pediatrics, Walter Reed Army Medical Center, Washington, District of Columbia 20307, USA. jeremy.v.edwards@us.army.mil
Simmons
Elizabeth
E
Cordero
Steve
S
Lieuw
Kenneth
K
Roberts
Stephen
S
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D012166:Retinal Hemorrhage / Q000473:pathology* / Q000628:therapy; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D016692:Receptors, Antigen, T-Cell, gamma-delta