NG108-15 hybrid cells take up but do not synthesize serotonin.
The mouse neuroblastoma x rat glioma hybrid cell line, NG108-15, does not synthesize serotonin from tryptophan, although the cells take up tryptophan and serotonin in a saturable manner from serum-supplemented incubation medium. Since serum commonly used to supplement the growth medium contains serotonin, it is concluded that appreciable levels of serotonin found in NG108-15 cells are attributable to uptake of serotonin from the serum-supplemented medium.
Hilibrand
A S
AS
Laboratory of Neuroendocrine Regulation, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technoloy, Cambridge, MA 02139, U.S.A.
Ingrid Richardson
U
U
Blusztajn
J K
JK
Wurtman
R J
RJ