title: Intersection between metabolic dysfunction, high fat diet consumption, and brain aging.
abstract: Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these aspects are altered in aging individuals, remains to be elucidated. An increasing number of individuals regularly consume a diet high in fat, with high-fat diet consumption known to be sufficient to promote metabolic dysfunction, although the links between high-fat diet consumption and aging are only now beginning to be elucidated. In this review we discuss the potential role for age-related metabolic disturbances serving as an important basis for deleterious perturbations in the aging brain. These data not only have important implications for understanding the basis of brain aging, but also may be important to the development of therapeutic interventions which promote successful brain aging.
authors.affiliation: Pennington Biomedical Research Center/Louisiana State University System, Baton Rouge, Louisiana 70808-4124, USA.
authors.forename: Romina M
authors.initials: RM
authors.lastname: Uranga
authors.forename: Annadora J
authors.initials: AJ
authors.lastname: Bruce-Keller
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Morrison
authors.forename: Sun Ok
authors.initials: SO
authors.lastname: Fernandez-Kim
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Ebenezer
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.forename: Kalavathi
authors.initials: K
authors.lastname: Dasuri
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Keller
mesh_terms: D050154:Adiposity; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004041:Dietary Fats; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D004041:Dietary Fats