title: Relationship between oral amiodarone and inappropriate therapy from an implantable cardioverter defibrillator.
abstract: BACKGROUND
  This study evaluated the efficacy of amiodarone for avoiding inappropriate therapies by implantable cardioverter defibrillators (ICDs).
  
  
  RESULTS
  A total of 232 patients with structural heart disease (58+/-13 years; 78% males) who underwent an initial ICD implantation were retrospectively investigated to compare baseline characteristics and event rates of inappropriate ICD therapy delivery between patients with oral amiodarone therapy (amiodarone group, n=116) and those without (non-amiodarone group, n=116). During a mean follow-up of 29+/-21 months, inappropriate therapies occurred less frequently in the amiodarone group than in the non-amiodarone group (12% vs 27%, P=0.0068). As a cause of inappropriate ICD therapy, only atrial fibrillation (AF) significantly differed between the groups (3% vs 12%, P=0.01). The results of multivariate logistic regression analysis showed that amiodarone therapy (odds ratio (OR) 0.38, 95% confidence interval (CI) 0.19-0.77, P=0.0073) and no history of spontaneous AF (OR 0.27, 95%CI 0.13-0.57, P=0.0007) were independent predictors of a lower risk of inappropriate ICD therapy.
  
  
  CONCLUSIONS
  In the present group of ICD patients with structural heart disease, inappropriate therapy delivery occurred predominantly in those with spontaneous AF and/or without amiodarone.
authors.affiliation: Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nagai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Satomi
authors.forename: Takashi
authors.initials: T
authors.lastname: Noda
authors.forename: Hideo
authors.initials: H
authors.lastname: Okamura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Wataru
authors.initials: W
authors.lastname: Shimizu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suyama
authors.forename: Naohiko
authors.initials: N
authors.lastname: Aihara
authors.forename: Shiro
authors.initials: S
authors.lastname: Kamakura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kurita
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage*; D001281:Atrial Fibrillation; D017147:Defibrillators, Implantable / Q000009:adverse effects*; D005260:Female; D006331:Heart Diseases / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D000638:Amiodarone