Common drug interactions leading to adverse drug events in the intensive care unit: management and pharmacokinetic considerations.
Critically ill patients are predisposed to drug interactions because of the complexity of the drug regimens they receive in the intensive care setting. Drugs may affect the absorption, distribution, metabolism, and/or elimination of an object drug and consequently alter the intended pharmacologic response and potentially lead to an adverse event. Certain disease states that afflict critically ill patients may also amplify an intended pharmacologic response and potentially result in an unintended effect. A team approach is important to identify, prevent, and address drug interactions in the intensive care setting and optimize patient outcomes.
Papadopoulos
John
J
Arnold & Marie Schwartz College of Pharmacy and Director of Pharmacotherapy-Division of Pharmacotherapy and New York University Langone Medical Center, New York, New York, USA. papadopoulos@nyumc.org
Smithburger
Pamela L
PL
D015415:Biomarkers; D003422:Critical Care / Q000379:methods; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007362:Intensive Care Units; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D010599:Pharmacokinetics; D013270:Stomach / Q000503:physiopathology; D014481:United States
D015415:Biomarkers