Human mammary tumor virus in inflammatory breast cancer.
The authors have found that retroviral sequences with 85% to 95% homology to the mouse mammary tumor virus were present in 40% of the sporadic breast cancers of American women. These sequences were not found in normal breasts or other tumors. A whole proviral structure was detected in 2 tumors. Breast cancer cells in culture were shown to contain and shed betaretroviral particles. This virus was designated human mammary tumor virus (HMTV). The authors have investigated the presence of HMTV sequences in a variety of breast conditions and geographic locations. Here they report that inflammatory breast cancer from American women shows a higher incidence of viral sequences (71%) than sporadic breast cancers. Similar incidence has been found in inflammatory breast cancers from Tunisia, and in gestational breast cancers. Because these conditions represent highly invasive malignancies, it is concluded that HMTV is sometimes associated with a particularly malignant phenotype.
Pogo
Beatriz G-T
BG
Division of Hematology/Medical Oncology, Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. beatriz.pogo@mssm.edu
Holland
James F
JF
Levine
Paul H
PH
D000818:Animals; D030121:Betaretrovirus / Q000235:genetics; D001943:Breast Neoplasms / Q000276:immunology / Q000821:virology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000821:virology*; D008325:Mammary Neoplasms, Experimental / Q000821:virology*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D012367:RNA, Viral / Q000032:analysis*; D017386:Sequence Homology, Amino Acid
D012367:RNA, Viral