title: What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma.
abstract: OBJECTIVE
  To determine if there is a relation between the follicle-stimulating hormone (FSH) and oestradiol levels with values found in bone mineral density, at lumbar spinal and femoral neck levels, in patients with spontaneous premature ovarian failure (POF) as at the time of diagnosis.
  
  
  METHODS
  Cross-sectional study. Eighty-five patients were selected with a diagnosis of POF. Inclusion criteria. Forty women with bone mineral density (BMD) in any of the regions, that is, lumbar spine column or femoral neck. Forty-two age-matched healthy women were included as controls.
  
  
  RESULTS
  The average FSH value found was 80.11 mUI/ml, while the oestradiol average value was 37.2 pg/ml. The FSH values were correlated with the BMD values at the lumbar spinal column (p < 0.002) and the femoral neck (p < 0.002). The oestradiol values did not bear any relation with the BMD values in L2-L4 (p = 0.420) nor with the femoral neck (p = 0.868).
  
  
  CONCLUSIONS
  High FSH concentrations, but not oestradiol, are positively associated with bone mass loss in both skeletal regions, in patients with spontaneous POF.
authors.affiliation: CLINICAS' Hospital, Gynecology Division, Gynaecological Endocrinology Section, Buenos Aires, República Argentina. mbelenpl@hotmail.com
authors.forename: Maria Belen Perez
authors.initials: MB
authors.lastname: Lana
authors.forename: Vanesa
authors.initials: V
authors.lastname: Straminsky
authors.forename: Claudia
authors.initials: C
authors.lastname: Onetto
authors.forename: Juliana Martinez
authors.initials: JM
authors.lastname: Amuchastegui
authors.forename: Georgina
authors.initials: G
authors.lastname: Blanco
authors.forename: Liliana
authors.initials: L
authors.lastname: Galluzzo
authors.forename: Sergio
authors.initials: S
authors.lastname: Provenzano
authors.forename: Manuel
authors.initials: M
authors.lastname: Nolting
mesh_terms: D000328:Adult; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D005272:Femur Neck / Q000473:pathology; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D009839:Oligomenorrhea / Q000503:physiopathology; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone