title: [Immunity in human schistosomiasis: hope for a vaccine].
abstract: Schistosomiasis remains a major worldwide public health problem in several endemic areas despite implementation of control measures. Vaccination would be an effective, long-term treatment option for future control of schistosomiasis. Although several parasite antigens have been identified as schistosomiasis vaccine candidates, major hurdles must still be overcome to develop a vaccine suitable for clinical trials in the field. Better understanding of immune responses to Schistosoma infection in both animal models and humans suggests that development of a vaccine is possible. The purpose of this review is to summarize the mechanisms of protective immunity against Schistosoma infection and to provide perspective on the development of a vaccine.
authors.affiliation: Département d'épidémiologie des affections parasitaires, Faculté de médecine, de pharmacie et d'odontostomatologie, Bamako, Mali. kouriba@mrtcbko.org
authors.forename: B
authors.initials: B
authors.lastname: Kouriba
authors.forename: B
authors.initials: B
authors.lastname: Traore
authors.forename: D
authors.initials: D
authors.lastname: Diemert
authors.forename: M A
authors.initials: MA
authors.lastname: Thera
authors.forename: A
authors.initials: A
authors.lastname: Dolo
authors.forename: A
authors.initials: A
authors.lastname: Tounkara
authors.forename: O
authors.initials: O
authors.lastname: Doumbo
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D016052:Protozoan Vaccines / Q000627:therapeutic use*; D012547:Schistosoma / Q000276:immunology; D012552:Schistosomiasis / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control
chemical_list: D007074:Immunoglobulin G; D016052:Protozoan Vaccines; D007073:Immunoglobulin E