Formation of the cytotoxic aldehyde acrolein during in vitro degradation of cyclophosphamide.
Alarcon
R A
RA
Meienhofer
J
J
D000171:Acrolein / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D003520:Cyclophosphamide / Q000737:chemistry / Q000493:pharmacokinetics*; D005740:Gases; D008297:Male; D008861:Microsomes; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D051381:Rats; D011916:Rats, Inbred F344; D013696:Temperature; D013997:Time Factors
D000447:Aldehydes; D000970:Antineoplastic Agents; D005740:Gases; D009249:NADP; D000171:Acrolein; D003520:Cyclophosphamide; D010100:Oxygen