title: Klebsiella pneumoniae bacteraemia complicating rotavirus gastroenteritis in two infants with glucocorticoid deficiency.
abstract: Rotavirus gastroenteritis was complicated by Klebsiella Pneumoniae bacteraemia in two infants with glucocorticoid deficient conditions who were treated with 'stress dose' hydrocortisone during their illness. Delayed healing in the context of glucocorticoid administration combined with damage from rotavirus infection may result in increased risk of mucosal invasion by gastrointestinal bacteria and subsequent enteric gram-negative bacteraemia.
authors.affiliation: Department of Endocrinology and Diabetes, Royal Children's Hospital, Brisbane, Australia. daniellelongmore@yahoo.com.au
authors.forename: Danielle K
authors.initials: DK
authors.lastname: Longmore
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Batch
authors.forename: Sarah K
authors.initials: SK
authors.lastname: McMahon
authors.forename: Louise S
authors.initials: LS
authors.lastname: Conwell
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005759:Gastroenteritis / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000172:deficiency*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000627:therapeutic use; D007018:Hypopituitarism / Q000150:complications / Q000151:congenital / Q000188:drug therapy; D007223:Infant; D007710:Klebsiella Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D007711:Klebsiella pneumoniae; D008297:Male; D012400:Rotavirus Infections / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006854:Hydrocortisone