[Morphological changes in the structure, regional blood circulation and content of the prostaglandins in the rats intestinal mucosa at different NSAIDS effects].
In the experiment on white rats reproduced the damage to the intestinal mucosa after administration of selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) within 24 hours and for 14 days. After the autopsy was measured the index injury (II), the content of prostaglandins (PGs) and cytokines in extracts of intestinal mucosa. Was established that the reduction of PGs was combined with an increase in II. Long reception of NSAIDs (14 days) causes greater damage to the submucous layer, without visible macroscopic changes.
Tkachenko
E V
EV
Varvanina
G G
GG
Droszdov
V N
VN
Trubitsina
I E
IE
Chikunova
B Z
BZ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects*; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D011453:Prostaglandins