Glycemic control influences serum angiogenin concentrations in patients with type 2 diabetes.
OBJECTIVE
Because diabetes is the most frequent factor responsible for microvascular and macrovascular disease, we investigated angiogenin serum levels within the diabetic patient group.


METHODS
We investigated 49 patients who met the criteria to be in the diabetic group. Forty nondiabetic patients were included in the control group. We set A1C <7% as well-controlled diabetes. Serum angiogenin level was measured using the enzyme-linked immunosorbent assay method.


RESULTS
Serum angiogenin levels of poorly controlled patients with type 2 diabetes were significantly lower than those of group with well-controlled diabetes (361.23 +/- 126.03 ng/ml vs. 446.37 +/- 134.10 ng/ml; P = 0.001). Moreover, they were characterized by a significantly longer duration of the disease (P = 0.006), higher BMI (P = 0.0003), and higher systolic blood pressure (P = 0.01). Levels of total cholesterol, triglycerides, LDL, and HDL were not significantly different in both groups.


CONCLUSIONS
Patients with poorly controlled type 2 diabetes (A1C >7%) have lower angiogenin levels than patients with well-controlled diabetes.
Siebert
Janusz
J
Department of Family Medicine, University Centre for Cardiology, Medical University of Gdansk, Gdansk, Poland. jsiebert@gumed.edu.pl
Reiwer-Gostomska
Magdalena
M
Mysliwska
Jolanta
J
Marek
Natalia
N
Raczynska
Krystyna
K
Glasner
Leopold
L
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012259:Ribonuclease, Pancreatic / Q000097:blood*
D006442:Glycated Hemoglobin; D012259:Ribonuclease, Pancreatic; C046366:angiogenin