title: Embryonic expression of the chicken Krüppel-like (KLF) transcription factor gene family.
abstract: The Krüppel-like transcription factors (KLF) are zinc finger proteins that activate and suppress target gene transcription. Although KLF factors have been implicated in regulating many developmental processes, a comprehensive gene expression analysis has not been reported. Here we present the chicken KLF gene family and expression during the first five days of embryonic development. Fourteen chicken KLF genes or expressed sequences have been previously identified. Through synteny analysis and cDNA mapping, we have identified the KLF9 gene and determined that the gene presently named KLF1 is the true ortholog of KLF17 in other species. In situ hybridization expression analyses show that in general KLFs are broadly expressed in multiple cell and tissue types. Expression of KLFs 3, 7, 8, and 9, is widespread at all stages examined. KLFs 2, 4, 5, 6, 10, 11, 15, and 17 show more restricted patterns that suggest multiple functions during early stages of embryonic development.
authors.affiliation: Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724-5217, USA. pba@email.arizona.edu
authors.forename: Parker B
authors.initials: PB
authors.lastname: Antin
authors.forename: Maricela
authors.initials: M
authors.lastname: Pier
authors.forename: Terry
authors.initials: T
authors.lastname: Sesepasara
authors.forename: Tatiana A
authors.initials: TA
authors.lastname: Yatskievych
authors.forename: Diana K
authors.initials: DK
authors.lastname: Darnell
mesh_terms: D000818:Animals; D001483:Base Sequence; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics* / Q000378:metabolism; D004625:Embryo, Nonmammalian; D005260:Female; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D016335:Zinc Fingers / Q000235:genetics
chemical_list: C489676:KLF9 protein, human; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C080774:erythroid Kruppel-like factor