Metabolic and nonmetabolic regulatory functions of peroxisome proliferator-activated receptor beta.
OBJECTIVE
This review focuses on the emerging knowledge about peroxisome proliferator-activated receptor beta regulatory functions on metabolism, inflammation, and cellular stress.


RESULTS
Recent publications have confirmed the important roles of peroxisome proliferator-activated receptor beta in adaptive metabolic responses of skeletal muscle and have also implicated the nuclear receptor in the regulation of inflammation and oxidative stress in various tissues. The mechanisms implicated in these effects have been partially elucidated.


CONCLUSIONS
Peroxisome proliferator-activated receptors mediate the transcriptional effects of fatty acids and fatty acid derivatives and regulate many physiological functions, including metabolism and development. Use of potent and specific agonists revealed that activation of peroxisome proliferator-activated receptor beta efficiently reverses some metabolic syndrome-associated abnormalities by affecting metabolic, inflammatory, and oxidative stress responses in several tissues through both genomic and nongenomic modes of action.
Grimaldi
Paul A
PA
Inserm U907, Faculté de Médecine, Nice, France. grimaldi@unice.fr
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism*; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D018919:Neovascularization, Physiologic; D018384:Oxidative Stress; D048068:PPAR-beta / Q000378:metabolism*
D048068:PPAR-beta