title: [Modern aspects of acne pathogenesis].
abstract: BACKGROUND
  Acne is worldwide the most common skin disease.
  
  
  METHODS
  Suitable therapeutic regimens of the varying clinical phenotypes require good knowledge of the pathogenesis of the illness.
  
  
  CONCLUSIONS
  Acne vulgaris is an inflammatory disorder at whose emergence androgens, PPAR ligands, regulating neuropeptides and environmental factors are probably involved. These factors interrupt the natural cycling process in the sebaceous gland follicle and support the transition of microcomedones to comedones and inflammatory lesions. Proinflammatory lipids, chemokines and cytokines overtake the role of mediators for the development of acne lesions. Bacterial antigens can potentate the inflammatory phenomena.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie/Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau-Rosslau. christos.zouboulis@klinikumdessau.de
authors.forename: Christos C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D000152:Acne Vulgaris / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D000942:Antigens, Bacterial / Q000097:blood; D003430:Cross-Sectional Studies; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D009479:Neuropeptides / Q000097:blood; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics; D011247:Pregnancy; D011425:Propionibacterium acnes / Q000472:pathogenicity; D012307:Risk Factors; D012931:Social Environment; D051193:Toll-Like Receptors / Q000235:genetics; D055815:Young Adult
chemical_list: D000728:Androgens; D000942:Antigens, Bacterial; D018836:Inflammation Mediators; D009479:Neuropeptides; D047492:Peroxisome Proliferator-Activated Receptors; D051193:Toll-Like Receptors