[Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure].
OBJECTIVE
To investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.


METHODS
32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.


RESULTS
Left ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.


CONCLUSIONS
Metoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.
Gao
Wen-qian
WQ
Department of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China. gwqbj08@sina.com
Han
Chun-guang
CG
Zhao
Yue-xiang
YX
Wang
Qiong
Q
Zhu
Ping
P
Yang
Ting-shu
TS
Liu
Yong-xue
YX
D000369:Aged, 80 and over; D002908:Chronic Disease; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008790:Metoprolol / Q000494:pharmacology*
C496567:GRK2 protein, human; D054769:G-Protein-Coupled Receptor Kinase 2; D008790:Metoprolol