Transcriptional regulation of T helper 17 cell differentiation.
The third lineage of T helper subsets, Th17, has recently been identified as an IL- 17-producing CD4+ Th cell, and its functions and regulatory mechanisms have been extensively characterized in immune responses. Functional studies have provided evidence that Th17 cells are important for the modulation of autoimmune responses, such as chronic asthma, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. Murine Th17 cell differentiation is enhanced by the coordinated functions of distinct cytokines including TGFbeta, IL-6, IL-21, and IL-23, whereas IL-2, IL-4, IFNgamma, and IL-27 inhibit its differentiation. In addition, Th17 cells are controlled by several transcription factors such as RORgammat, IRF4, BATF, FoxP3, T-bet, PPARgamma, E-FABP, and SOCSs. This review focuses on the functions and regulatory mechanisms of several transcription factors in the control of Th17 cell differentiation.
Hwang
Eun Sook
ES
Division of Life and Pharmaceutical Sciences, College of Phamacy, Ewha Womans University, Center for Cell Signaling and Drug Discovery Research, 11-1 Daehyeon-dong, Seodaemun-gu, Seoul 120-750, Korea. eshwang@ewha.ac.kr
D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D051858:Forkhead Transcription Factors / Q000502:physiology; D006801:Humans; D050835:Interferon Regulatory Factors / Q000502:physiology; D020381:Interleukin-17 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000502:physiology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D050796:STAT3 Transcription Factor / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D000099218:Interferon Regulatory Factor-4
D050976:Basic-Leucine Zipper Transcription Factors; D051858:Forkhead Transcription Factors; D050835:Interferon Regulatory Factors; D020381:Interleukin-17; D015850:Interleukin-6; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D047495:PPAR gamma; D050796:STAT3 Transcription Factor; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D000099218:Interferon Regulatory Factor-4; C099359:BATF protein, human; C418974:FOXP3 protein, human