Hybrid liposomes inhibit the growth of cholangiocarcinoma by induction of cell cycle arrest in G1 phase.
Specific accumulation and cell cycle arrest were observed in human cholangiocarcinoma cells by hybrid liposomes composed of 90 mol% L-alpha-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(21)dodecyl ether (C(12)(EO)(21)) without affecting normal cholangiocytes.
Towata
Tomomi
T
Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan.
Komizu
Yuji
Y
Kariya
Ryusho
R
Suzu
Shinya
S
Matsumoto
Yoko
Y
Kobayashi
Naoya
N
Wongkham
Chaisiri
C
Wongkham
Sopit
S
Ueoka
Ryuichi
R
Okada
Seiji
S
D001653:Bile Ducts, Intrahepatic / Q000166:cytology / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D018281:Cholangiocarcinoma / Q000188:drug therapy* / Q000473:pathology; D004134:Dimyristoylphosphatidylcholine; D016193:G1 Phase / Q000187:drug effects*; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols; D014407:Tumor Cells, Cultured
D008081:Liposomes; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine