title: Predictors for neonatal thrombocytopenia in infants of thrombocytopenic mothers during pregnancy.
abstract: BACKGROUND
  Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated.
  
  
  METHODS
  We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42 weeks) born to 723 mothers with pregnancy-induced thrombocytopenia to define risk factors predicting thrombocytopenia in this group.
  
  
  RESULTS
  Thrombocytopenia was diagnosed in 2.2% of the infants. Multivariate analysis showed that infants with thrombocytopenia were more likely to be male, to be born at lower gestational age and to have lower birth weight associated with lower maternal platelets counts. Maternal platelet counts of 100-149 x 10(9)/L, 50-99 x 10(9)/L, and <50 x 10(9)/L corresponded respectively to 1.7%, 4.3%, and 12.5% of neonatal thrombocytopenia (P = 0.031).
  
  
  CONCLUSIONS
  Routine blood counts are recommended, in particular for male infants with low birth weight born to mothers with moderate-to-severe thrombocytopenia.
authors.affiliation: Department of Neonatology, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
authors.forename: Ayala
authors.initials: A
authors.lastname: Maayan-Metzger
authors.forename: Lea
authors.initials: L
authors.lastname: Leibovitch
authors.forename: Irit
authors.initials: I
authors.lastname: Schushan-Eisen
authors.forename: Tzipora
authors.initials: T
authors.lastname: Strauss
authors.forename: Gili
authors.initials: G
authors.lastname: Kenet
authors.forename: Jacob
authors.initials: J
authors.lastname: Kuint
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D012307:Risk Factors; D013921:Thrombocytopenia / Q000097:blood / Q000175:diagnosis*