Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa.
OBJECTIVE
The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN).


METHODS
Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-alpha and interleukin (IL)-1beta), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form.


RESULTS
BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (P<0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (P<0.05 for both).


CONCLUSIONS
Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.
Nogueira
J-P
JP
Department of Nutrition, Metabolic diseases, Endocrinology, University of Aix-Marseille 2, 'La Timone' Hospital, Marseille, France.
Maraninchi
M
M
Lorec
A-M
AM
Corroller
A B-L
AB
Nicolay
A
A
Gaudart
J
J
Portugal
H
H
Barone
R
R
Vialettes
B
B
Valéro
R
R
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D052018:Bulimia Nervosa / Q000097:blood*; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000097:blood*; D020738:Leptin / Q000097:blood*; D009043:Motor Activity; D052243:Resistin / Q000097:blood*; D055815:Young Adult
D052242:Adiponectin; D020738:Leptin; D052243:Resistin