title: [Benz(a)pyrene antibodies are a marker of carcinogenic load in coal-processing workers].
abstract: The authors studied benz(a)pyrene-specific secretory and serum antibody ratios (Ka) in 249 workers of the Kemerovo Power Station, by applying their modified enzyme immunoassay technique. There were 37 (20.5%) and 4 (5.8%) cases with Ka >2 at the preset immunoassay parameters of the 180 and 69 workers of mainline production and auxiliary units, respectively. A Ka value of >2 was found in 35 (21.6%) of the 162 males and only in 6 (6.9%) of the 87 females of the whole sample, in 29 (26.1%) of the 111 smokers and in 12 (8.7%) of the 138 non-smokers. The technique is proposed to study specific immune reactions and exposure to carcinogens primarily in workers of the enterprises processing coal and other types of fuel.
authors.forename: A N
authors.initials: AN
authors.lastname: Glushkov
authors.forename: E G
authors.initials: EG
authors.lastname: Poleniuk
authors.forename: S A
authors.initials: SA
authors.lastname: Mun
authors.forename: S A
authors.initials: SA
authors.lastname: Larin
authors.forename: S F
authors.initials: SF
authors.lastname: Zinchuk
mesh_terms: D000906:Antibodies / Q000097:blood / Q000276:immunology; D001564:Benzo(a)pyrene / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood / Q000276:immunology*; D002273:Carcinogens; D003032:Coal Mining; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000276:immunology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012800:Siberia
chemical_list: D000906:Antibodies; D014408:Biomarkers, Tumor; D002273:Carcinogens; D001564:Benzo(a)pyrene