title: Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus.
abstract: A new series of antimicrobial derivatives [3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 [3-(4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and Enterococcus faecium with no activity against Gram-negative bacteria.
authors.affiliation: Department of Chemistry, The University of Jordan, Amman, Jordan.
authors.forename: Raed A
authors.initials: RA
authors.lastname: Al-Qawasmeh
authors.forename: Mario
authors.initials: M
authors.lastname: Huesca
authors.forename: Venkata
authors.initials: V
authors.lastname: Nedunuri
authors.forename: Robert
authors.initials: R
authors.lastname: Peralta
authors.forename: Jim
authors.initials: J
authors.lastname: Wright
authors.forename: Yoon
authors.initials: Y
authors.lastname: Lee
authors.forename: Aiping
authors.initials: A
authors.lastname: Young
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D007211:Indoles; D014640:Vancomycin