Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways.
We investigated the phagocytosis-enhancing activity of green tea polyphenols, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) catechin (+C) and strictinin, using VD3-differentiated HL60 cells. EGCG, EGC, ECG and strictinin, but not EC and +C, increased the phagocytic activity of macrophage-like cells, and a caspase inhibitor significantly inhibited phagocytic activities. These results suggest that the pyrogallol-type structure in green tea polyphenols may be important for enhancement of the phagocytic activity through caspase signaling pathways.
Monobe
Manami
M
National Institute of Vegetable and Tea Science, NARO, 2769 Kanaya, Shimada, Shizuoka, 428-8501, Japan, monobe@affrc.go.jp.
Ema
Kaori
K
Tokuda
Yoshiko
Y
Maeda-Yamamoto
Mari
M