title: HLA-G polymorphism patterns show lack of detectable association with recurrent spontaneous abortion.
abstract: Human leukocyte antigen-G (HLA-G) is a class I non-classical molecule that is predominantly expressed on the extravillous cytotrophoblasts at foetal-maternal interface during pregnancy. We recruited 143 recurrent spontaneous abortion (RSA) and 150 control couples for the study. DNA-based typing of the HLA-G was carried out to explore if we can validate the patterns of association reported elsewhere or find association of novel HLA-G alleles with RSA in the Indian population. We also evaluated the role of allele sharing in couples with RSA. We did not find association of any of the HLA-G alleles with RSA in our study. There is a general trend of increase in sharing among the RSA couples, but the increase is not significant. The results suggest that the HLA-G alleles or the allele sharing by couples may not play a significant role in the manifestation of RSA in the Indian context albeit more studies are required before making any definitive statement.
authors.affiliation: Molecular Anthropology Group, Biological Anthropology Unit, Indian Statistical Institute, Habsiguda, Hyderabad, Andhra Pradesh, India.
authors.forename: M
authors.initials: M
authors.lastname: Aruna
authors.forename: P S
authors.initials: PS
authors.lastname: Sudheer
authors.forename: S
authors.initials: S
authors.lastname: Andal
authors.forename: S
authors.initials: S
authors.lastname: Tarakeswari
authors.forename: A G
authors.initials: AG
authors.lastname: Reddy
authors.forename: K
authors.initials: K
authors.lastname: Thangaraj
authors.forename: L
authors.initials: L
authors.lastname: Singh
authors.forename: B M
authors.initials: BM
authors.lastname: Reddy
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000022:Abortion, Spontaneous / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D004247:DNA