title: Primary skull-based yolk-sac tumour: case report and review of central nervous system germ cell tumours.
abstract: Primary intra-cranial germ-cell tumours (GCT) are rare and it is important to differentiate them histologically as their prognosis and treatment is quite different. Moreover, highly malignant non-germinomatous GCT (NG GCT) comprise a small portion of these tumours with limited data available on appropriate treatment approaches. We present the case of a 22-year-old male with a unique primary skull-based yolk-sac subtype NG GCT with a literature review of current treatment options. To our knowledge, there have not been any previously published reports of a primary yolk-sac tumour arising from the petrous apex.
authors.affiliation: Department of Diagnostic Imaging, The Ottawa Hospital, Civic Campus, Ottawa, Canada. ramanverma@gmail.com
authors.forename: Raman
authors.initials: R
authors.lastname: Verma
authors.forename: Shawn
authors.initials: S
authors.lastname: Malone
authors.forename: Christina
authors.initials: C
authors.lastname: Canil
authors.forename: Gerard
authors.initials: G
authors.lastname: Jansen
authors.forename: Howard
authors.initials: H
authors.lastname: Lesiuk
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D018240:Endodermal Sinus Tumor / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D055815:Young Adult