Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis.
We report the rapid and dramatic efficacy of propranolol in 8 infants with infantile hepatic hemangiomas. The degree of response varied from a significant improvement to a complete resolution of hepatic lesions. Heart failure and hypothyroidism resolved, and hepatomegaly decreased. No side-effects of the drug were noted.
Mazereeuw-Hautier
Juliette
J
Dermatology Department, Paul Sabatier University and the Department of Dermatology, Children's Hospital, Toulouse, France. mazereeuw-hautier.j@chu-toulouse.fr
Hoeger
Peter H
PH
Benlahrech
Sarah
S
Ammour
Amir
A
Broue
Pierre
P
Vial
Julie
J
Ohanessian
Gerard
G
Léauté-Labrèze
Christine
C
Labenne
Marc
M
Vabres
Pierre
P
Rössler
Jochen
J
Bodemer
Christine
C
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000517:prevention & control; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D014665:Vasodilator Agents; D011433:Propranolol