Dependence receptors: mechanisms of an announced death.
Dependence receptors form a family of functionally related receptors which are all able to induce two completely opposite intracellular signals depending on the availability of their ligand. Indeed, in its presence, they mediate a positive, classical signal transduction of survival, differentiation or migration but without it, they trigger a negative signal which leads to cell death. The molecular mechanisms involved in triggering cell death in the absence of ligand are starting to be unravelled: dependence receptors are recruited at well-defined domains at the plasma membrane, they trigger cell death through a monomeric form, they are cleaved by caspases and they recruit a caspase activating complex.
Thibert
Chantal
C
Apoptosis, Cancer and Development Laboratory, Equipe labellisée La Ligue, Université de Lyon, CNRS UMR5238, Lyon, France. chantal.thibert@ujf-grenoble.fr
Fombonne
Joanna
J
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism
D011956:Receptors, Cell Surface; D011987:Receptors, Steroid; D020169:Caspases