title: [Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation].
abstract: OBJECTIVE
  To evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation (OGD).
  
  
  METHODS
  A pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model.
  
  
  RESULTS
  Polydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells.
  
  
  CONCLUSIONS
  Polydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.forename: Huan-bing
authors.initials: HB
authors.lastname: Lin
authors.forename: Heng
authors.initials: H
authors.lastname: Zhou
authors.forename: Jiang-ping
authors.initials: JP
authors.lastname: Xu
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000517:prevention & control; D002470:Cell Survival; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D009569:Nitric Oxide / Q000032:analysis; D010100:Oxygen / Q000378:metabolism* / Q000494:pharmacology; D016716:PC12 Cells; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D005960:Glucosides; D020011:Protective Agents; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005947:Glucose; D010100:Oxygen; C058229:polydatin