Genetic structure of the Spanish population.
BACKGROUND
Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.


RESULTS
In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.


CONCLUSIONS
In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
Gayán
Javier
J
Department of Structural Genomics, Neocodex, Sevilla, Spain.
Galan
José J
JJ
González-Pérez
Antonio
A
Sáez
María Eugenia
ME
Martínez-Larrad
María Teresa
MT
Zabena
Carina
C
Rivero
M Carmen
MC
Salinas
Ana
A
Ramírez-Lorca
Reposo
R
Morón
Francisco J
FJ
Royo
Jose Luis
JL
Moreno-Rey
Concha
C
Velasco
Juan
J
Carrasco
José M
JM
Molero
Eva
E
Ochoa
Carolina
C
Ochoa
María Dolores
MD
Gutiérrez
Marta
M
Reina
Mercedes
M
Pascual
Rocío
R
Romo-Astorga
Alejandro
A
Susillo-González
Juan Luis
JL
Vázquez
Enrique
E
Real
Luis M
LM
Ruiz
Agustín
A
Serrano-Ríos
Manuel
M
D000328:Adult; D000368:Aged; D005260:Female; D018628:Gene Dosage / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013030:Spain