title: Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis.
abstract: Overexpression of transmembrane 4 L six family member 5 (TM4SF5), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion, and tumor metastasis remain unknown. Using in vitro hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials were examined. We found that TM4SF5 expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects. Altogether, TM4SF5-mediated migration and invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5-mediated hepatocellular cancers.
authors.affiliation: Cancer Research Institute, Seoul National University, Seoul 110-799, Korea.
authors.forename: Sin-Ae
authors.initials: SA
authors.lastname: Lee
authors.forename: Tae You
authors.initials: TY
authors.lastname: Kim
authors.forename: Tae Kyoung
authors.initials: TK
authors.lastname: Kwak
authors.forename: Hyeonjung
authors.initials: H
authors.lastname: Kim
authors.forename: Semi
authors.initials: S
authors.lastname: Kim
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Park
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Moonjae
authors.initials: M
authors.lastname: Cho
authors.forename: Jung Weon
authors.initials: JW
authors.lastname: Lee
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement / Q000502:physiology*; D005260:Female; D022781:Hepatocytes / Q000166:cytology / Q000473:pathology / Q000502:physiology; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009362:Neoplasm Metastasis
chemical_list: D008565:Membrane Proteins; C111029:TM4SF5 protein, human