[Peripheral vascular remodeling in arterial hypertension in conditions of occupational risk: the issues of pathogenesis and telmisartan therapy].
OBJECTIVE
To study the clinical and functional features of peripheral vessels and the systemic mechanisms of their remodeling in arterial hypertension (AH) only and concurrent with vibration disease (VD) and to treat patients.


METHODS
The investigation included 184 males: 75 patients with AH (Group 1), 72 with AH concurrent with VD (Group 2), and 37 healthy individuals. To evaluate the functional status of the endothelium and peripheral vessels, the authors measured the blood levels of nitric oxide, endothelin-1, proinflammatory cytokines, homocysteine, and von Willebrand factor. Doppler ultrasonography of the brachial and radial arteries was performed. Telmisartan was used for therapy.


RESULTS
Both group patients were found to have significant endothelial dysfunction (severer in VD) and the signs of brachial artery remodeling, also severer in VD. Six-month telmisartan therapy favored blood pressure normalization, reduced clinical symptoms, improved endothelial function and peripheral artery functional status.


CONCLUSIONS
Successful antihypertensive therapy with the angiotensin II receptor type 1 blocker makes it possible to achieve a clinical effect in both AH only and AH concurrent with VD.
Shpagina
L A
LA
Shpagin
I S
IS
Gerasimenko
O N
ON
Zueva
M A
MA
Chachibaia
Z K
ZK
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use*; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D016207:Cytokines / Q000276:immunology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D017534:Radial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D000077333:Telmisartan; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler; D014732:Vibration / Q000009:adverse effects
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D016207:Cytokines; D000077333:Telmisartan