title: Interactions between gut inflammation and arthritis/spondylitis.
abstract: OBJECTIVE
  The spectrum of spondyloarthritis is characterized by the intriguing co-occurrence of gut and joint inflammation, although no obvious anatomical link exists.
  
  
  RESULTS
  Data from animal models identify stromal cells as important players in pathogenesis, although signalling through TNFRI appeared to be sufficient for development of combined gut and joint inflammation. Interleukin-23 receptor was identified as a susceptibility locus for ankylosing spondylitis.
  
  
  CONCLUSIONS
  Human genome studies combined with animal model research provide us with new evidence in the fascinating field of the gut-joint axis. However, how these newly identified genetic associations can influence the immunological environment remains to be elucidated.
authors.affiliation: Department of Internal Medicine, Rheumatology, University Hospital of Ghent, Ghent, Belgium.
authors.forename: Peggy
authors.initials: P
authors.lastname: Jacques
authors.forename: Dirk
authors.initials: D
authors.lastname: Elewaut
authors.forename: Herman
authors.initials: H
authors.lastname: Mielants
mesh_terms: D000818:Animals; D001168:Arthritis / Q000150:complications* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000235:genetics / Q000276:immunology; D018123:Receptors, Interleukin / Q000235:genetics / Q000276:immunology; D013166:Spondylitis / Q000150:complications* / Q000235:genetics / Q000276:immunology; D013272:Stomach Diseases / Q000150:complications* / Q000235:genetics / Q000276:immunology
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin