title: [Retreatment with peginterferon plus ribavirin in chronic hepatitis C patients: our own experiences].
abstract: Retreatment with peginterferon plus ribavirin was initiated in 26 patients with hepatitis C virus genotype 1b infection (17 relapsers after the first course of therapy, 9 non-responders). So far, retreatment has been completed in 19 patients, one patient achieved a sustained virologic response, and 3 patients were relapsers. Therapy was discontinued in 14 patients (9 non-responders) because of a lack of a treatment response, and in 1 patient due to adverse effects. Retreatment is a new chance for patients with chronic hepatitis C infection. However successful outcome is rare especially in non-responders.
authors.affiliation: Klinika infekcního lékarství, Fakultní nemocnice Ostrava. ludek.roznovsky@fnspo.cz
authors.forename: L
authors.initials: L
authors.lastname: Roznovský
authors.forename: I
authors.initials: I
authors.lastname: Orságová
authors.forename: L
authors.initials: L
authors.lastname: Petrousová
authors.forename: J
authors.initials: J
authors.lastname: Mrázek
authors.forename: A
authors.initials: A
authors.lastname: Kloudová
authors.forename: L
authors.initials: L
authors.lastname: Kabieszová
authors.forename: J
authors.initials: J
authors.lastname: Kůrková
authors.forename: M
authors.initials: M
authors.lastname: Pospísek
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011994:Recombinant Proteins; D012008:Recurrence; D019233:Retreatment; D012254:Ribavirin / Q000008:administration & dosage*
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a