title: Tricyclic antidepressants intoxication in Tehran, Iran: epidemiology and associated factors.
abstract: BACKGROUND
  Tricyclic antidepressant (TCA) intoxication contributes a large number of drug toxicities with serious complications. There are a few studies about factors associated with TCA intoxication. This study therefore aimed to identify determinants of this type of intoxication.
  
  
  METHODS
  A cross-sectional study was carried out at Loghman-Hakim Poison Hospital during a 6-month period. All poisoned patients aged >12 years presented to this hospital during the mentioned period were evaluated. Then, TCA-poisoned patients were compared with other drug intoxications as the control group to determine factors associated with TCA intoxications.
  
  
  RESULTS
  There were 9809 admissions, of which 1583 (16.1%) patients including 601 (38%) males were intoxicated with TCAs. Mean age of the subjects was 26.5 + 10 years. Most of the TCA intoxications (74.4%) were intentional (p = 0.01). Amitriptyline was the most frequent agent followed by Nortriptyline. There was no significant difference between TCA and non-TCA intoxications regarding the mortality (1.3% in TCA vs. 1.1% in others, p = 0.45). Logistic regression analysis revealed that sex, addiction status, and history of psychological problems have association with TCA intoxication.
  
  
  CONCLUSIONS
  The results of this study are helpful in identifying individuals who are prone to TCA intoxication and may be useful in implementation of preventive strategies.
authors.affiliation: Sina Trauma and Surgery Research Center, Sina Hospital, Tehrarn University of Medical Sciences, Tehran, Iran.
authors.forename: Saied
authors.initials: S
authors.lastname: Dianat
authors.forename: Mohammd-Reza
authors.initials: MR
authors.lastname: Zarei
authors.forename: Hossein
authors.initials: H
authors.lastname: Hassanian-Moghaddam
authors.forename: Neda
authors.initials: N
authors.lastname: Rashidi-Ranjbar
authors.forename: Reza
authors.initials: R
authors.lastname: Rahimian
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Rasouli
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D003430:Cross-Sectional Studies; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D009661:Nortriptyline / Q000506:poisoning; D011041:Poisoning / Q000453:epidemiology* / Q000209:etiology; D013406:Suicide, Attempted / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D009661:Nortriptyline