title: Age-dependent differences in the neural mechanisms supporting long-term declarative memories.
abstract: Autobiographical memories enable us to mentally reconstruct and relive past events, which is essential for one's personal identity. Unfortunately, this complex memory system is susceptible to age-related deterioration, possibly changing the way episodic information is being processed in older adults. The aim of this study was to investigate whether age influences the neural activity associated with content (episodic versus semantic) and remoteness (recent versus remote) of memories. Using functional magnetic resonance imaging in healthy older and young adults, we found significant age-dependent differences in the neural networks underlying memory content but not remoteness. Our data suggest an age-associated functional reorganization in the neural networks underlying long-term declarative memory. Relative increase in activity of posterior brain regions could reflect changes in visuospatial processing during episodic memory retrieval in older adults.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany. markus.donix@uniklinikum-dresden.de
authors.forename: Markus
authors.initials: M
authors.lastname: Donix
authors.forename: Katrin
authors.initials: K
authors.lastname: Poettrich
authors.forename: Peter H
authors.initials: PH
authors.lastname: Weiss
authors.forename: Annett
authors.initials: A
authors.lastname: Werner
authors.forename: Rüdiger
authors.initials: R
authors.lastname: von Kummer
authors.forename: Gereon R
authors.initials: GR
authors.lastname: Fink
authors.forename: Vjera A
authors.initials: VA
authors.lastname: Holthoff
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009415:Nerve Net / Q000098:blood supply / Q000502:physiology; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen