title: [Respiratory papillomatosis--new methods of treatment].
abstract: BACKGROUND
  Respiratory papillomatosis is caused by HPV. The most common location in head and neck is larynx, palatine tonsils and arches of palate, uvula and mucosa oral and nasal cavity. The disease is benign but recurrent. The aim of this study was to estimate new methods of treatment respiratory papillomatosis based on intralesional injection of cidofovir into sites where papillomas had just been excised.
  
  
  METHODS
  The purpose of the study were 59 patients treating in Otolaryngology Clinic Stomatology Department Medical University of Warsaw. The treatment was based on surgical excision of papilloma and after it intralesional injection of cidofovir in after 4-5 weeks.
  
  
  RESULTS
  We observed the patients during 28 months. 41 patients had 4 times intralesional injection of cidofovir. 18 patients had increased number of injection of ciodofovir because of recurrent papilloma. Rest of this group of the patients clinical studies showed remission disease.
  
  
  CONCLUSIONS
  Surgery with intralesional cidofovir injection in the place after removal of papilloma is very effective methods. We observed that this treatment caused long lasting remission of papilloma recurrence.
authors.affiliation: Klinika Otolaryngologii, Instytutu Stomatologii, Warszawskiego Uniwersytetu Medycznego.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nowaczewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Wójtowicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kukwa
authors.forename: Jan
authors.initials: J
authors.lastname: Ratajczak
authors.forename: Marek
authors.initials: M
authors.lastname: Tulibacki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000008:administration & dosage*; D000077404:Cidofovir; D003131:Combined Modality Therapy; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D063065:Organophosphonates / Q000008:administration & dosage*; D010212:Papilloma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011044:Poland; D012074:Remission Induction; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir