Two novel antibiotic resistance genes, tet(44) and ant(6)-Ib, are located within a transferable pathogenicity island in Campylobacter fetus subsp. fetus.
New tetracycline and streptomycin resistance genes, tet(44) and ant(6)-Ib, were identified in Campylobacter fetus subsp. fetus within a transferable pathogenicity island that is typically unique to Campylobacter fetus subsp. venerealis. The 640-amino-acid tetracycline resistance determinant, Tet 44, belongs to a class of proteins that confers resistance to tetracycline and minocycline by ribosomal protection. The 286-amino-acid streptomycin resistance determinant, ANT(6)-Ib, belongs to a family of aminoglycoside nucleotidyltransferases. The resistance phenotypes were demonstrated by gene inactivation and expression.
Abril
Carlos
C
Centre for Zoonoses, Bacterial Animal Diseases and Antimicrobial Resistance, University of Berne, CH-3001 Bern, Switzerland.
Brodard
Isabelle
I
Perreten
Vincent
V
D001426:Bacterial Proteins / Q000235:genetics; D002168:Campylobacter fetus / Q000187:drug effects* / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D044404:Genomic Islands / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology; D008969:Molecular Sequence Data; D009713:Nucleotidyltransferases / Q000235:genetics; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D013307:Streptomycin / Q000494:pharmacology*; D013753:Tetracycline Resistance / Q000235:genetics*
D001426:Bacterial Proteins; D009713:Nucleotidyltransferases; D008911:Minocycline; D013307:Streptomycin