Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy.
After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4(+) T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.
Sarmati
L
L
Clinical Infectious Diseases, Tor Vergata University, Rome, Italy.
Parisi
S G
SG
Andreoni
C
C
Nicastri
E
E
Buonomini
A R
AR
Boldrin
C
C
Dori
L
L
Montano
M
M
Tommasi
C
C
Andreis
S
S
Vullo
V
V
Palù
G
G
Andreoni
M
M
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D006678:HIV / Q000145:classification / Q000472:pathogenicity*; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D056189:Viral Tropism
D019380:Anti-HIV Agents