[The expression and clinical significance of Wnt-1 induced secreted protein-1 in breast carcinoma].
OBJECTIVE
To investigate the expression of Wnt-1 induced secreted protein-1 (WISP-1) between breast cancer and paired normal breast tissues and to explore the significance of WISP-1 in breast cancer tumorigenesis.


METHODS
The mRNA and protein expressions of WISP-1 in human breast cancer were measured by Quantitative Real-Time RT-PCR and immunohistochemical staining and further analyzed the relationship between WISP-1 expression and clinic pathologic characters.


RESULTS
WISP-1 expression in breast cancer was higher than that in normal breast tissue (P = 0.001). The mRNA expression level of WISP-1 was correlated with tumor size, staging, lymph node status, differentiated degree and HER-2 status (P < 0.05). WISP-1 protein expression level was correlated with lymph node status, differentiated degree and HER-2 status (P < 0.05).


CONCLUSIONS
WISP-1 expression in human breast cancer increases significantly and may play a key role in the invasion and metastasis of human breast cancer.
Hu
Rui
R
Department of Mastologic Surgery, Sichuan Cancer Hospital, Chengdu 610041, China.
Tian
Chao
C
Meng
Wen-jian
WJ
Zhang
Jian-hui
JH
Li
Lui
L
Zhang
Pu-rong
PR
Long
Qi-ming
QM
Tao
Ping
P
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D055511:CCN Intercellular Signaling Proteins; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism
D055511:CCN Intercellular Signaling Proteins; D047908:Intracellular Signaling Peptides and Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; C116396:CCN4 protein, human; C508053:ERBB2 protein, human