Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment.
OBJECTIVE
There is little evidence that dehydroepiandrosterone (DHEA) has beneficial effects on physical and psychological functions in older women. We investigated the effect of DHEA supplementation on cognitive function and ADL in older women with cognitive impairment.


METHODS
A total of 27 women aged 65-90 years (mean ± standard deviation, 83 ± 6) with mild to moderate cognitive impairment (Mini-Mental State Examination, MMSE; 10-28/30 points), receiving long-term care at a facility in Japan were enrolled. Twelve women were assigned to receive DHEA 25 mg/day p.o. for 6 months. The control group (n = 15) matched for age and cognitive function was followed without hormone replacement. Cognitive function was assessed by MMSE and Hasegawa Dementia Scale-Revised (HDS-R), and basic activities of daily living (ADL) by Barthel Index at baseline, 3 and 6 months. Plasma hormone levels including testosterone, DHEA, DHEA-sulfate and estradiol were also followed up.


RESULTS
After 6 months, DHEA treatment significantly increased plasma testosterone, DHEA and DHEA-sulfate levels by 2-3-fold but not estradiol level compared to baseline. DHEA administration increased cognitive scores and maintained basic ADL score, while cognition and basic ADL deteriorated in the control group (6-month change in DHEA group vs control group; MMSE, +0.6 ± 3.2 vs -2.1 ± 2.2, P < 0.05; HDS-R, +2.8 ± 2.8 vs -0.3 ± 4.1, P < 0.05; Barthel Index, +3.7 ± 7.1 vs -2.7 ± 4.6, P = 0.05). Among the cognitive domains, DHEA treatment improved verbal fluency (P < 0.05).


CONCLUSIONS
DHEA supplementation in older women with cognitive impairment may have beneficial effects on cognitive function and ADL.
Yamada
Shizuru
S
Department of Geriatric Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Akishita
Masahiro
M
Fukai
Shiho
S
Ogawa
Sumito
S
Yamaguchi
Kiyoshi
K
Matsuyama
Jun
J
Kozaki
Koichi
K
Toba
Kenji
K
Ouchi
Yasuyoshi
Y
D000203:Activities of Daily Living; D000276:Adjuvants, Immunologic / Q000097:blood / Q000494:pharmacology*; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000517:prevention & control; D003687:Dehydroepiandrosterone / Q000097:blood / Q000494:pharmacology*; D019587:Dietary Supplements; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007564:Japan; D008134:Long-Term Care
D000276:Adjuvants, Immunologic; D003687:Dehydroepiandrosterone; D004958:Estradiol