Polysomnographic assessment of sleep disturbances in children with developmental disabilities and seizures.
The aim of this study was to assess the presence of sleep breathing disorder and periodic leg movements during sleep (PLMS), and to evaluate NREM sleep instability in a group of children with mental retardation (MR) and epilepsy. Eleven subjects with MR and epilepsy (6 males, age range 9-17 years) were recruited for this study. A control group was formed by 11 age-matched normal children. Three children with MR and epilepsy showed an apnea-hypopnea index > 5, two of them had also a PLMS index > 5. Another subject had only a PLMS index > 5. Children with MR showed many sleep architecture differences compared to controls. They also showed higher cyclic alternating pattern (CAP) rate, increased A1 index, long and less numerous CAP sequences than controls. A detailed investigation and treatment of sleep disorders in children affected by MR and epilepsy may have a positive impact on seizure control.
Miano
Silvia
S
Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Via C. Ruggero 73, 94018, Troina, Italy.
Bruni
Oliviero
O
Aricò
Debora
D
Elia
Maurizio
M
Ferri
Raffaele
R
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002658:Developmental Disabilities / Q000150:complications*; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D017286:Polysomnography; D012119:Respiration; D012640:Seizures / Q000150:complications*; D012893:Sleep Wake Disorders / Q000175:diagnosis* / Q000209:etiology*; D018709:Statistics, Nonparametric