title: (1)H NMR Study of the solution structure of sarafotoxin-S6b.
abstract: Sarafotoxin-S6b has been synthesized and studied by (1)H NMR in 50 50 acetonitrile/water mixture. All spin systems were identified and assigned with the aid of 2D experiments. On the basis of these data, a 3D structure of sarafotoxin is proposed and compared to that of [Nle(7)]endothelin obtained in the same conditions. From this study, it appeared that sarafotoxin-S6b and [Nle(7)]endothelin roughly share the same 3D structure, the main differences being located in the 4-7 loop bearing the sequence variation.
authors.affiliation: Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Aumelas
authors.forename: L
authors.initials: L
authors.lastname: Chiche
authors.forename: E
authors.initials: E
authors.lastname: Mahe
authors.forename: D
authors.initials: D
authors.lastname: Le-Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Sizun
authors.forename: P
authors.initials: P
authors.lastname: Berthault
authors.forename: B
authors.initials: B
authors.lastname: Perly