title: Pathological changes and immunoexpression of p63 gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical study.
abstract: OBJECTIVE
  The aim of this study was to examine the pathologic changes and immunoexpressivity of p63 gene in dental follicles (DFs) of asymptomatic partially and completely impacted lower third molars.
  
  
  METHODS
  Clinical and radiologic examinations included 50 DFs with no signs of abnormal radiolucency (follicular space <2.5 mm), taken from 50 patients.
  
  
  RESULTS
  Histopathologic examinations of the specimens revealed 47 normal dental follicular tissues, 1 ameloblastoma, and 2 dentigerous cysts. p63 Immunoexpressivity was stronger in the DFs of the group with completely impacted teeth (64%),than it was in the case of DFs of the group with partially impacted teeth (40%).
  
  
  CONCLUSIONS
  Stronger p63 gene immunoexpression in the group with completely impacted teeth might be a consequence of bigger number of stem cells than it is in the case of the group with partially impacted teeth. This study also supports prophylactic removal of impacted teeth because of the development of pathologies associated with them.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University Capa, Istanbul, Turkey. amilabrkic@hotmail.com
authors.forename: Amila
authors.initials: A
authors.lastname: Brkić
authors.forename: Sevcihan
authors.initials: S
authors.lastname: Mutlu
authors.forename: Hülya
authors.initials: H
authors.lastname: Koçak-Berberoğlu
authors.forename: Vakur
authors.initials: V
authors.lastname: Olgaç
mesh_terms: D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000378:metabolism / Q000473:pathology; D003795:Dental Sac / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D003803:Dentigerous Cyst / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008964:Molar, Third / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D011859:Radiography; D014095:Tooth, Impacted / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*
chemical_list: C081876:CKAP4 protein, human; D008565:Membrane Proteins