Migraine and epilepsy: a focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects.
The association of epilepsy and migraine has been long recognized. Migraine and epilepsy are both chronic disorders with episodic attacks. Furthermore, headache may be a premonitory or postdromic symptom of seizures, and migraine headaches may cause seizures per se (migralepsy). Migraine and epilepsy are comorbid, sharing pathophysiological mechanisms and common clinical features. Several recent studies identified common genetic and molecular substrates for migraine and epilepsy, including phenotypic-genotypic correlations with mutations in the CACNA1A, ATP1A2, and SCN1A genes, as well as in syndromes due to mutations in the SLC1A3, POLG, and C10orF2 genes. Herein, we review the relationship between migraine and epilepsy, focusing on clinical aspects and some recent pathophysiological and molecular studies.
Bianchin
Marino Muxfeldt
MM
Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. mmbianchin@hotmail.com
Londero
Renata Gomes
RG
Lima
José Eduardo
JE
Bigal
Marcelo Eduardo
ME
D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D009154:Mutation / Q000235:genetics
D000700:Analgesics; D000927:Anticonvulsants