title: Neurosarcoidosis presenting as an anterior horn syndrome.
abstract: We report a 43 year old man who developed progressive weakness of all extremities with fasciculation over four months. Neurological examination was consistent with an anterior horn syndrome. CSF examination showed elevated opening pressure and a lymphocytic pleocytosis. The diagnosis of sarcoidosis was confirmed by muscle and lacrimal gland biopsies. He was treated with the combination of corticosteroids and intravenous immunoglobulin with almost complete resolution of his symptoms a few weeks after discharge. We hypothesize that meningeal granulomatous inflammation compressed the exiting anterior roots which resulted in motor dysfunction with preservation of peripheral sensory fibers.
authors.affiliation: Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA. souayani@umdnj.edu
authors.forename: Nizar
authors.initials: N
authors.lastname: Souayah
authors.forename: Ameer E
authors.initials: AE
authors.lastname: Hassan
authors.forename: Natalia
authors.initials: N
authors.lastname: Krivitskaya
authors.forename: Huey-Jen
authors.initials: HJ
authors.lastname: Lee
authors.forename: Andreas
authors.initials: A
authors.lastname: Michas-Martin
authors.forename: A Manuel
authors.initials: AM
authors.lastname: Cruz
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Cho
mesh_terms: D000328:Adult; D004576:Electromyography / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000473:pathology / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000150:complications / Q000175:diagnosis*; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D013035:Spasm / Q000209:etiology / Q000473:pathology