[Oxidative stress in patients on mechanical ventilation].
BACKGROUND
The appearance and intensity of oxidative stress were analyzed in the course of mechanical ventilation and parameters that could point toward potential lung damage.


METHODS
In three time intervals on day 1, 3 and 7 of mechanical ventilation, parameters such as: triglycerides, cholesterol, lactate, serum lactic dehydrogenase, acid-base balance and lipid peroxidation products--thiobarbituric acid reactive substances, were followed in 30 patients with head injuries.


RESULTS
A decrease in the level of partial oxygen pressure (PaO2) (p < 0.01) and PaO2/FiO2 index (p < 0.05) in arterial blood was recorded on day 3 of mechanical ventilation. This was accompanied with an increase in alveolar-arterial difference (AaDO2) (p < 0.05), thiobarbituric acid reactive substances (p < 0.001) and lactic dehydrogenase (p < 0.001) comparing to day 1 of mechanical ventilation. The patients with initial PaO2 > 120 mmHg, had significant increase of thiobarbituric acid reactive substances and AaDO2 (p < 0.05) and fall of PaO2 (p < 0.001) on day 3 of mechanical ventilation.


CONCLUSIONS
Oxidative stress and lipid peroxide production are increased during third day of mechanical ventilation leading to disruption of oxygen diffusion through alveolar-capillary membrane and reduction of parameters of oxygenation.
Marjanović
Vesna
V
Klinika za dedju hiruriju i ortopediju, Klinicki centar Nis, Nis. pajalaza@sbb.rs
Dordević
Vidosava
V
Marjanović
Goran
G
D000136:Acid-Base Equilibrium; D000328:Adult; D005260:Female; D006801:Humans; D042844:L-Lactate Dehydrogenase (Cytochrome) / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D010100:Oxygen / Q000097:blood; D012121:Respiration, Artificial; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D017392:Thiobarbituric Acid Reactive Substances; D042844:L-Lactate Dehydrogenase (Cytochrome); D010100:Oxygen