title: Comparative efficacy of rabeprazole and pantoprazole in the control of nocturnal Acid output and intragastric acidity.
abstract: OBJECTIVE
  Nocturnal reflux is a largely undiagnosed and unmanaged condition predisposing to multiple esophageal complications. We evaluated the effects of rabeprazole and pantoprazole on nocturnal intragastric pH and gastric acid output during Day 1 of therapy following the consumption of standard meals.
  
  
  METHODS
  The study had a double-blinded, randomized, two-way crossover design, and involved 15 patients with a history of mild reflux. Following an overnight fast, patients were given either rabeprazole (20 mg) or pantoprazole (40 mg) prior to the first of three standard Western meals. They then underwent overnight continuous intragastric pH monitoring and gastric acid output measurement. The drug effect was analyzed using a two-treatment, two-period crossover mixed model.
  
  
  RESULTS
  The percentage of time during which the mean intragastric pH was greater than 4.0 and gastric acid output was less than 2.0 was higher for oral rabeprazole (p<0.05). The inhibition of acid output was greater for rabeprazole at almost all time points. Furthermore, the mean time-matched pH values differed significantly over the first 8.3 hours (p<0.05).
  
  
  CONCLUSIONS
  On day 1, oral rabeprazole inhibited acid output to a greater extent and for a longer period than pantoprazole, and the intragastric pH was significantly higher for rabeprazole than for pantoprazole over the first 8.3 hours.
authors.affiliation: Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Hank S
authors.initials: HS
authors.lastname: Wang
authors.forename: David S
authors.initials: DS
authors.lastname: Oh
authors.forename: Ariana
authors.initials: A
authors.lastname: Anderson
authors.forename: Jose
authors.initials: J
authors.lastname: Nieto
authors.forename: Phuong
authors.initials: P
authors.lastname: Tien
authors.forename: Gordon
authors.initials: G
authors.lastname: Ohning
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Pisegna