title: Cutaneous hyalohyphomycosis in a girdled lizard (Cordylus giganteus) caused by the Chrysosporium anamorph of Nannizziopsis vriesii and successful treatment with voriconazole.
abstract: The Chrysosporium anamorph of Nannizziopsis vriesii was associated with dermatomycosis and high mortality in a group of captive giant girdled lizards (Cordylus giganteus). Treatment of one of the infected girdled lizards with voriconazole, which was selected on the basis of in vitro sensitivity testing of the isolate, resulted in resolution of lesions and negative fungal cultures from the skin. Three hours after oral administration of 10 mg/kg, the plasma level of voriconazole exceeded the 0.25-μg/mL minimal inhibitory concentration tenfold. In conclusion, administration of voriconazole at 10 mg/kg of body weight once daily for 10 weeks resulted in clinical cure and was well tolerated. A longer follow-up time and larger studies will be necessary to determine the long-term efficacy and safety of this treatment in giant girdled lizards.
authors.affiliation: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. tom.hellebuyck@UGent.be
authors.forename: Tom
authors.initials: T
authors.lastname: Hellebuyck
authors.forename: Kris
authors.initials: K
authors.lastname: Baert
authors.forename: Frank
authors.initials: F
authors.lastname: Pasmans
authors.forename: Lieven
authors.initials: L
authors.lastname: Van Waeyenberghe
authors.forename: Lies
authors.initials: L
authors.lastname: Beernaert
authors.forename: Koen
authors.initials: K
authors.lastname: Chiers
authors.forename: Patrick
authors.initials: P
authors.lastname: De Backer
authors.forename: Freddy
authors.initials: F
authors.lastname: Haesebrouck
authors.forename: An
authors.initials: A
authors.lastname: Martel
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002912:Chrysosporium; D060605:Hyalohyphomycosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D008116:Lizards; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole