title: Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.
abstract: Kv1.5 channels are homotetramers of alpha-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kv beta 1.3 assemblies with Kv alpha 1.5 and modifies its gating and pharmacology. A further knowledge of alpha-beta interactions and pharmacology will lead a better design of new drugs.
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), C/Arturo Duperier 4, 28029 Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: González
authors.forename: Miren
authors.initials: M
authors.lastname: David
authors.forename: Cristina
authors.initials: C
authors.lastname: Moreno
authors.forename: Alvaro
authors.initials: A
authors.lastname: Macías
authors.forename: Carmen
authors.initials: C
authors.lastname: Valenzuela
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology; D002045:Bupivacaine / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051664:Kv1.3 Potassium Channel / Q000737:chemistry* / Q000378:metabolism; D051666:Kv1.5 Potassium Channel / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D000779:Anesthetics, Local; C097044:KCNAB1 protein, human; D051664:Kv1.3 Potassium Channel; D051666:Kv1.5 Potassium Channel; D002045:Bupivacaine