Hormonal therapy with estradiol and testosterone implants: bone protection?
OBJECTIVE
To assess bone mineral density (BMD) in postmenopausal women using estradiol and testosterone hormonal implants comparing to that of patients without hormonal therapy.


METHODS
Sixty-one patients were followed in prospective cohort study separated in Group 1, 34 women using implants and Group 2, 27 women without implants and BMD assessment through Dual energy X-ray absorptiometry was conducted in the beginning of follow-up and after 1 year.


RESULTS
The average lumbar spine BMD in Group 1 was 1.123 ± 0.16 kg/m(2) and 1.144 ± 0.18 kg/m(2) after 1 year, p=0.39 and femur BMD was 0.922 ± 0.16 kg/m(2) and 0.957 ± 0.12 kg/m(2) after 1 year of treatment, p=0.076. In Group 2, the initial lumbar spine BMD average was 1.064 ± 0.2 kg/m(2) and after 1 year, 1.001 ± 0.23 kg/m(2), p=0.112 and femur BMD changed from 0.928 ± 0.14 kg/m(2) to 0.881 ± 0.15 kg/m(2) after 1 year, p=0.046.


CONCLUSIONS
BMD variance between the groups in the period of 1 year showed that the combination of estradiol and testosterone promoted bone protection in post menopausal women.
Britto
Renata
R
Department of Gynecology, Federal University of Bahia (UFBA), Salvador, Bahia, Brazil. renatalopesbritto@gmail.com
Araújo
Leila
L
Barbosa
Ione
I
Silva
Lidia
L
Rocha
Sidinéia
S
Valente
Ana P
AP
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D019610:Cytoprotection / Q000187:drug effects; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D005269:Femur / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence; D013739:Testosterone / Q000008:administration & dosage*
D004343:Drug Implants; D013739:Testosterone; D004958:Estradiol