Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis.
Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S(N)2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry.
Baumgartner
Corinne
C
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, MC 164-30, Pasadena, CA 91125, USA.
Ma
Sandy
S
Liu
Qi
Q
Stoltz
Brian M
BM
D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D000480:Alkynes; D011083:Polycyclic Compounds; C531521:cortistatin A