title: Efficient and improved synthesis of Telmisartan.
abstract: An efficient synthesis of the angiotensin II receptor antagonist Telmisartan (1) is presented involving a cross coupling of 4-formylphenylboronic acid 10 with 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline (11) as the key step (90% yield). The benzimidazole moiety 15 was constructed regioselectively via a reductive amination-condensation sequence, replacing the alkylation of the preformed benzimidazole step in the previously published route. This methodology overcomes many of drawbacks associated with previously reported syntheses.
authors.affiliation: Applied Chemistry Department, Sardar Vallabhbhai National Institute of Technology, Surat-395 007, India.
authors.forename: A Sanjeev
authors.initials: AS
authors.lastname: Kumar
authors.forename: Samir
authors.initials: S
authors.lastname: Ghosh
authors.forename: G N
authors.initials: GN
authors.lastname: Mehta