Polymyxin-direct hemoperfusion for sepsis-induced multiple organ failure.
We report a case of multiple organ failure caused by the Bacillus cereus infection during acute lymphoblastic leukemia therapy, who was treated successfully. A 15-year-old male developed (B. cereus) sepsis on the 19th day after chemotherapy initiation. Polymyxin-direct hemoperfusion for septic shock was started, followed by continuous hemodiafiltration. His condition improved after starting the hemoperfusion. At the onset of sepsis, elevated levels of serum inflammatory cytokines, anti-inflammatory cytokines, and plasminogen-activator inhibitor complex-1 were observed. Serum levels of these cytokines and bioactive substances decreased after blood purification therapy, which correlated with the improvement of clinical symptoms.
Hirabayashi
Koichi
K
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. k-hira@naganoch.gr.jp
Shiohara
Masaaki
M
Saito
Shoji
S
Tanaka
Miyuki
M
Yanagisawa
Ryu
R
Tsuruta
Goro
G
Fukuyama
Tetsuhiro
T
Hidaka
Yoshihiko
Y
Nakazawa
Yozo
Y
Shimizu
Takashi
T
Sakashita
Kazuo
K
Koike
Kenichi
K
D000293:Adolescent; D001409:Bacillus cereus / Q000302:isolation & purification; D016207:Cytokines / Q000097:blood; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology* / Q000628:therapy*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011113:Polymyxins / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D018805:Sepsis / Q000150:complications* / Q000628:therapy*
D016207:Cytokines; D017395:Plasminogen Activator Inhibitor 1; D011113:Polymyxins