title: Inflammatory breast cancer in Tunisia: epidemiological and clinical trends.
abstract: Inflammatory breast cancer (IBC) is characterized by a peculiar geographic distribution in incidence, being described as more common in Tunisia and the region of North Africa. The authors performed a systematic review of published literature on rapidly progressing breast cancer and IBC in Tunisia and analyzed the evolution in epidemiology, clinical presentation, treatment, and therapeutic results. They collected, analyzed, and compared all the indexed Tunisian articles about rapidly progressing breast cancer and IBC since the 1970s opening of the Institut Salah Azaiz Institute in Tunis. In the 1970s, rapidly progressing breast cancer diagnosis was based on the Poussée Evolutive classification (1-3). Since the 1990s, IBC diagnosis has been based on the American Joint Committee on Cancer Poussée Evolutive 3/T4d staging. The authors compared the historical data to the most recent publications in terms of epidemiology, clinical features, treatment, and therapeutic results. The most important historical report of rapidly progressing breast cancer concerned 340 patients, representing 58.5% of a cohort of 581 breast cancer patients collected from 1969 to 1974, including 320 (55.2%) with inflammatory signs, 37(6.5%) with Poussée Evolutive 2, and 283 (48.7%) with Poussée Evolutive 3. Subsequent papers have documented a steady decrease in incidence to the current 5% to 7% T4d/IBC. Since the 1970s, Poussée Evolutive in premenopausal woman has increased from 52.5% to 75%; rural predominance has persisted. The 5-year overall survival reached 28% by the year 2000. The authors' analysis demonstrated a trend of decreasing incidence of IBC diagnoses from 50% to presently <10%, probably related to a combination of factors, including the use of more stringent criteria (Poussée Evolutive 3/T4d) for IBC diagnosis and an improvement in the socioeconomic level of Tunisia.
authors.affiliation: Department of Medical Oncology, Salah Azaiz Institute, Tunis, Tunisia. hamouda.boussen@rns.tn
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Hatem
authors.initials: H
authors.lastname: Bouzaiene
authors.forename: Jamel
authors.initials: J
authors.lastname: Ben Hassouna
authors.forename: Tarek
authors.initials: T
authors.lastname: Dhiab
authors.forename: Fathi
authors.initials: F
authors.lastname: Khomsi
authors.forename: Farouk
authors.initials: F
authors.lastname: Benna
authors.forename: Amor
authors.initials: A
authors.lastname: Gamoudi
authors.forename: Nejib
authors.initials: N
authors.lastname: Mourali
authors.forename: Monia
authors.initials: M
authors.lastname: Hechiche
authors.forename: Khaled
authors.initials: K
authors.lastname: Rahal
authors.forename: Paul H
authors.initials: PH
authors.lastname: Levine
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology* / Q000628:therapy*; D005260:Female; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000175:diagnosis / Q000453:epidemiology*; D014416:Tunisia / Q000453:epidemiology