title: Association between adiponectin and metabolic syndrome in older adults from major cities of China.
abstract: OBJECTIVE
  To investigate the association between adiponectin and metabolic syndrome (MetS) and related diseases in older adults from major cities of China.
  
  
  METHODS
  A total of 2 049 adults at the age of 60-96 years from 18 major cities of China were enrolled in the study. Plasma adiponectin and insulin concentrations were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). The definitions proposed by International Diabetes Federation (IDF) and American Heart Association/National Heart, Lung, and Blood Institute (AHA/NLHBI) were used to identify MetS.
  
  
  RESULTS
  The adiponectin concentration increased with the advance of age and was higher in women than in men. The sex specific adiponectin concentration was inversely correlated with body mass index (BMI), waist circumference, diastolic blood pressure, triglycerides, glucose and fasting blood insulin, and positively correlated with HDL-C (P < 0.001). The adiponectin concentration decreased with increasing MetS components. Compared with the 4th sex-specific adiponectin quartile, the odds ratio (OR) for prevalent MetS-IDF and MetS-AHA/NLHBI in subjects of the 1st quartile group was 3.25 (95% CI: 2.24, 4.71) and 3.21 (95% CI: 2.26, 4.55), respectively. The association was independent of age, sex, life-style factors, medication, family history of chronic diseases, BMI, and HOMA-IR. The OR for MetS was much higher than those of MetS components and its related diseases.
  
  
  CONCLUSIONS
  Adiponectin is strongly associated with MetS independent of insulin resistance and obesity in older adults from major cities in China. The adiponectin concentration is a useful predictor for the risk of MetS.
authors.affiliation: National Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhuo
authors.forename: Zhi-Qing
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Fu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Piao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Yang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006801:Humans; D006949:Hyperlipidemias; D006973:Hypertension; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D056128:Obesity, Abdominal; D012727:Sex Characteristics
chemical_list: D052242:Adiponectin