title: Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high-cholesterol/high-fat diet in rats.
abstract: This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260-300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (-11.4% to -18.5%), LDL-C (-22% to -49.3%), and TG (-33.7% to -36.1%) levels and significantly increased HDL-C levels (16.3-55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats.
authors.affiliation: Functional Food Laboratory, Faculty of Food Science and Technology, School of Food Science and Nutrition, University of Putra Malaysia, Serdang, Selangor, Malaysia.
authors.forename: Patricia
authors.initials: P
authors.lastname: Matanjun
authors.forename: Suhaila
authors.initials: S
authors.lastname: Mohamed
authors.forename: Kharidah
authors.initials: K
authors.lastname: Muhammad
authors.forename: Noordin Mohamed
authors.initials: NM
authors.lastname: Mustapha
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D046068:Caulerpa / Q000737:chemistry*; D002784:Cholesterol / Q000008:administration & dosage* / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D028321:Plant Preparations / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000461:Rhodophyta / Q000737:chemistry*; D044647:Sargassum / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood; D014329:Tropical Climate
chemical_list: D002317:Cardiovascular Agents; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D028321:Plant Preparations; D014280:Triglycerides; D002784:Cholesterol; D005979:Glutathione Peroxidase