title: Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: an experimental study in the dog.
abstract: OBJECTIVE
  To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration.
  
  
  METHODS
  Contra-lateral one-wall intrabony [6 x 6 mm (wide/deep) versus 4 x 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval.
  
  
  RESULTS
  New cementum encompassed the entire intrabony component in both wide/deep (5.6 +/- 0.5 mm) and narrow/shallow (4.2 +/- 0.1 mm) defects; bone formation amounted to 5.6 +/- 0.6 and 4.0 +/- 0.8 mm, respectively. Mineralized bone encompassed 57.5%versus 65% and the bone biomaterial 11.6%versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare.
  
  
  CONCLUSIONS
  Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Aarhus, Aarhus, Denmark. stavropoulos@odont.au.dk
authors.forename: Andreas
authors.initials: A
authors.lastname: Stavropoulos
authors.forename: Ulf M E
authors.initials: UM
authors.lastname: Wikesjö
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002113:Calcification, Physiologic / Q000502:physiology; D002417:Cattle; D003094:Collagen; D024042:Collagen Type I / Q000627:therapeutic use; D003739:Dental Cementum / Q000473:pathology; D004285:Dogs; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008334:Mandible / Q000601:surgery; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology; D010513:Periodontal Ligament / Q000473:pathology; D012391:Root Resorption / Q000473:pathology; D013997:Time Factors; D020254:Tooth Ankylosis / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D024042:Collagen Type I; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen