title: New estrogenic compounds isolated from Broussonetia kazinoki.
abstract: Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Da Yeon
authors.initials: DY
authors.lastname: Lee
authors.forename: Do Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Hwa Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: YoungJoo
authors.initials: Y
authors.lastname: Lee
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Ryu
authors.forename: Bo-In
authors.initials: BI
authors.lastname: Jung
authors.forename: Yun Seon
authors.initials: YS
authors.lastname: Song
authors.forename: Jae-Ha
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D031623:Broussonetia / Q000737:chemistry*; D004967:Estrogens / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D048789:Phytoestrogens / Q000302:isolation & purification / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D020218:Response Elements / Q000187:drug effects; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D004967:Estrogens; D008024:Ligands; D010636:Phenols; D048789:Phytoestrogens; D011960:Receptors, Estrogen; C524287:broussonin A