[Chronic occupational bronchitis in workers of coal extracting enterprises in Kouzbass: role of endogenous factors].
The authors studied distribution of biochemical markers for HP, GC, EsD, AcP genes, polymorphism of GSTT1 (GST-theta 1), GSTM1 (GST-mu 1), locus WNTR of NOS3 gene (alleles A/B) in chronic dust bronchitis patients and in apparently healthy individuals. Genotypes EsD 1-2 and AcP bb individuals were proved to be most prone to the disease. Endogenous resistent factors for chronic dust bronchitis are genotypes GC 1-1, EsD 1-1, AcP bc.
Gafarov
N I
NI
Zakharenkov
V V
VV
Panev
N I
NI
Burdeĭn
A V
AV
Puzyrev
V P
VP
Rudko
A A
AA
D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D029481:Bronchitis, Chronic / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D043182:Carboxylesterase / Q000097:blood; D003031:Coal; D003032:Coal Mining; D004391:Dust; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D015995:Prevalence; D012800:Siberia / Q000453:epidemiology; D014809:Vitamin D-Binding Protein / Q000097:blood
D015415:Biomarkers; D003031:Coal; D004391:Dust; D006242:Haptoglobins; D014809:Vitamin D-Binding Protein; D043182:Carboxylesterase; C020118:ESD protein, human; D000135:Acid Phosphatase