Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction.
BACKGROUND
A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma.


METHODS
In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn.


RESULTS
Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides.


CONCLUSIONS
We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction.
Magro
Cynthia M
CM
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA. cym2003@med.cornell.edu
Cruz-Inigo
Andres E
AE
Votava
Henry
H
Jacobs
Michael
M
Wolfe
David
D
Crowson
A Neil
AN
D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects; D001706:Biopsy; D003875:Drug Eruptions / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000927:Anticonvulsants; D000928:Antidepressive Agents