title: Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: a prospective study.
abstract: OBJECTIVE
  To evaluate the effectiveness of a Q-switched Nd:YAG laser (MedLite C6; HOYA ConBio, Fremont, CA, USA) and 7% alpha arbutin solution (Skin Advance Laboratory, Japan) in the treatment of melasma.
  
  
  METHODS
  This was a prospective study of 35 refractory melasma cases treated with 10 weekly laser sessions, two monthly follow-up treatments and topical 7% alpha arbutin solution. Clinical photographs and severity grading on a 5-point scale were carried out by an independent observer at each visit.
  
  
  RESULTS
  At 6 months, 30% of study subjects received results in the excellent clearance category (> 81% reduction of melasma) and 36.7% received good (51-80% reduction) clearance. Mild and transient side effects included discomfort during treatment, erythema, whitening of fine hair and urticaria. Three cases of mottling hypo-pigmentation (8.57%) and two cases of recurrence of melasma (5.71%) were recorded.
  
  
  CONCLUSIONS
  Combination therapy with the MedLite C6 and 7% alpha arbutin solution is an effective and well-tolerated treatment for refractory melasma.
authors.affiliation: Kasemrad Aesthetic Center, Kasemrad Prachacheun Hospital, Bangsue, Bangkok, Thailand. niwatpol@gmail.com
authors.forename: Niwat
authors.initials: N
authors.lastname: Polnikorn
mesh_terms: D000328:Adult; D001104:Arbutin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000009:adverse effects / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects; D008548:Melanosis / Q000532:radiotherapy*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D001104:Arbutin