Effect of dietary boron on physiological responses in growing steers inoculated with bovine herpesvirus type-1.
Thirty-six Angus and Angus×Simmental steers were fed one of three dietary treatments; (1) control (no supplemental B), (2) 5 mg supplemental B/kg, and (3) 15 mg supplemental B/kg for 47 days to determine the effects of dietary boron (B) on disease resistance following an inoculation with bovine herpesvirus type-1 (BHV-1). On day 34 of the study steers were inoculated intranasally with BHV-1. Rectal temperatures began to elevate at day 2, and plasma tumor necrosis factor-α concentrations increased (P<0.05) by day 2 following BHV-1 inoculation. Plasma acute phase proteins were increased (P<0.01) while plasma interferon-γ was decreased (P<0.05) by day 4 post-inoculation. Supplementation of B increased (P<0.001) plasma B concentrations in a dose-responsive manner. However, dietary B did not affect the duration and severity of clinical signs of BHV-1 and had minimal effects on plasma acute phase proteins and cytokines.
Fry
R S
RS
Department of Animal Science, North Carolina State University, Box 7621, Raleigh, NC 27695-7621, USA.
Brown
T T
TT
Lloyd
K E
KE
Hansen
S L
SL
Legleiter
L R
LR
Robarge
W P
WP
Spears
J W
JW
D000210:Acute-Phase Reaction; D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001831:Body Temperature; D001895:Boron / Q000494:pharmacology*; D002417:Cattle; D016207:Cytokines / Q000097:blood; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007242:Herpesvirus 1, Bovine; D007241:Infectious Bovine Rhinotracheitis / Q000276:immunology*; D008297:Male; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D016207:Cytokines; D001895:Boron