title: X-linked chronic granulomatous disease with voriconazole-induced photosensitivity/ photoaging reaction.
abstract: Due to the mutations in the nicotinamide dinucleotide phosphate (NADPH) oxidase complex in X-linked chronic granulomatous disease (CGD), the phagocytic activity in these patients is curtailed by a dysfunctional respiratory burst. This can lead to life-threatening bacterial and fungal infections. The prognosis for patients with CGD has dramatically improved with the advent of effective prophylactic drugs targeting catalase-positive bacteria, opportunistic Gram-negative bacteria and fungi. Voriconazole, a second-generation triazole, is a commonly used agent for prophylaxis in this population. The authors report a case of photoaging and photosensitivity reaction associated with voriconazole exposure in a 10-year-old boy with X-linked CGD. With broad-spectrum sunscreen, topical steroids, and discontinuation of voriconazole, the patient showed significant improvement.
authors.affiliation: Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Frisch
authors.forename: Sharone K
authors.initials: SK
authors.lastname: Askari
authors.forename: Stacy Russel
authors.initials: SR
authors.lastname: Beaty
authors.forename: C Nicole
authors.initials: CN
authors.lastname: Burkemper
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D016868:Serratia Infections / Q000188:drug therapy / Q000209:etiology; D015595:Skin Aging / Q000187:drug effects; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole