title: No association between polymorphisms of WNT2 and schizophrenia in a Korean population.
abstract: BACKGROUND
  Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population.
  
  
  METHODS
  e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls.
  
  
  RESULTS
  Of the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction.
  
  
  CONCLUSIONS
  The present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.
authors.affiliation: College of Medicine, Soonchunhyang University, Chunan 336-745, Republic of Korea.
authors.forename: Hak-Jae
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Park
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Park
authors.forename: Ah-Rang
authors.initials: AR
authors.lastname: Cho
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Song
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D051154:Wnt2 Protein / Q000235:genetics*
chemical_list: C495244:WNT2 protein, human; D051154:Wnt2 Protein