Usefulness of autofluorescence imaging for estimating the extent of gastric neoplastic lesions: a prospective multicenter study.
OBJECTIVE
The aim of this study was to determine whether the margin of early to be detected gastric cancer (EGC) and gastric adenoma is easier to be detected with autofluorescence imaging (AFI) than with white-light endoscopy (WLE).


METHODS
A total of 102 lesions (48 EGCs and 54 gastric adenomas) found in 98 patients were removed endoscopically or surgically. The measured length of each pathology specimen was compared with the lengths estimated using WLE, AFI, and chromoendoscopy.


RESULTS
The lesions could be discriminated from surrounding mucosa by AFI in 86 cases (84.3%). The detection rates were similar for elevated lesions (85.1%) and flat/depressed lesions (82.9%, p=0.770). In terms of histology, the detection rate was slightly higher for adenomas (90.7%) than for cancer (77.1%, p=0.058). The estimated length was shorter than the pathologic length in 31.4% of cases when using WLE and 22.1% of cases when using AFI (p=0.168). The resection range was larger for EMR than for AFI in 24 of 80 cases (30.0%).


CONCLUSIONS
WLE tends to underestimate the size of EGCs, whereas AFI tends to overestimate their size.
Lee
Jun Haeng
JH
Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
Cho
Joo Yong
JY
Choi
Myung Gyu
MG
Kim
Joo Sung
JS
Choi
Kee Don
KD
Lee
Yong Chan
YC
Jang
Jae Young
JY
Chun
Hoon Jai
HJ
Seol
Sang Yong
SY