Highly oxygenated guaianolides from Artemisia dubia.
Investigation of a Chinese folk medicine, Artemisia dubia (syn. Artemisia subdigitata), has resulted in the isolation of eight new guaianolides (artemdubolides A-H, 1-8), and nineteen known sesquiterpene lactones. Their structures were elucidated primarily on the basis of spectroscopic methods, including extensive 2D NMR experiments. The cytotoxic activities of compounds 1-8 were evaluated against A549 (human lung adenocarcinoma), Colo205 (human colon carcinoma), HepG2 (human hepatoma), and MDA-MB-435 (human melanoma) cell lines. Compounds 2 and 5 showed weak cell growth inhibition of Colo205 and MDA-MB-435 cells.
Huang
Zheng-Sheng
ZS
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
Pei
Yue-Hu
YH
Liu
Chu-Mei
CM
Lin
Sheng
S
Tang
Jian
J
Huang
Da-Sen
DS
Song
Tai-Fa
TF
Lu
Long-Hai
LH
Gao
Yan-Ping
YP
Zhang
Wei-Dong
WD
D019306:Artemisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane