title: Design, synthesis and biological evaluation of trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides.
abstract: A modeling approach based on physico-chemical and pharmacokinetic properties, called Volsurf+, was used to design new trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides with antiproliferative activity. The synthesis and in vitro antitumor tests on two cell lines (MCF-7 and LNCap) confirmed Volsurf predicted activity values. An Almond model, derived to have an overall structural insight on the above compounds, supported the validity of Volsurf and provided guidelines for the synthesis of new compounds.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria, Catania, Italy. cg.fortuna@unict.it
authors.forename: Cosimo G
authors.initials: CG
authors.lastname: Fortuna
authors.forename: Vincenza
authors.initials: V
authors.lastname: Barresi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Musumarra
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007454:Iodides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D025341:Principal Component Analysis; D021281:Quantitative Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007454:Iodides; D013876:Thiophenes