title: Adverse drug events associated with disorders of coagulation.
abstract: Disorders of coagulation are common adverse drug events encountered in critically ill patients and present a serious concern for intensive care unit (ICU) clinicians. Dosing strategies for medications used in the ICU are typically developed for use in noncritically ill patients and, therefore, do not account for the altered pharmacokinetic and pharmacodynamic properties encountered in the critically ill as well as the increased potential for drug-drug interactions, given the far greater number of medications ordered. This substantially increases the risk for coagulation-related adverse reactions, such as a bleeding or prothrombotic events. Although many medications used in the ICU have the potential to cause coagulation disorders, the exact incidence will vary based on the specific medication, dose, concomitant drug therapy, ICU setting, and patient-specific comorbidities. Clinicians must strongly consider these factors when evaluating the risk/benefit ratio for a particular therapy. This review surveys recent literature documenting the risk for adverse drug reactions specific to bleeding and/or clotting with commonly used medications in the ICU.
authors.affiliation: Spectrum Health, Grand Rapids, MI, USA. jeffrey.barletta@spectrum-health.org
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Barletta
authors.forename: Brad
authors.initials: B
authors.lastname: Cooper
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Ohlinger
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects; D000925:Anticoagulants / Q000009:adverse effects; D000933:Antifibrinolytic Agents / Q000009:adverse effects; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000628:therapy; D001779:Blood Coagulation Factors / Q000009:adverse effects; D003102:Colloids / Q000009:adverse effects; D003422:Critical Care / Q000379:methods; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000628:therapy; D004921:Erythropoietin / Q000009:adverse effects; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects; D015942:Factor VIIa / Q000009:adverse effects; D005343:Fibrinolytic Agents / Q000009:adverse effects; D000077425:Fondaparinux; D006490:Hemostatics / Q000009:adverse effects; D006801:Humans; D011134:Polysaccharides / Q000009:adverse effects; D011486:Protein C / Q000009:adverse effects; D011994:Recombinant Proteins / Q000009:adverse effects; D013917:Thrombin / Q000037:antagonists & inhibitors; D013923:Thromboembolism / Q000188:drug therapy; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000890:Anti-Infective Agents; D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors; D003102:Colloids; D004966:Estrogens, Conjugated (USP); D005343:Fibrinolytic Agents; D006490:Hemostatics; D011134:Polysaccharides; D011486:Protein C; D011994:Recombinant Proteins; D004921:Erythropoietin; D014812:Vitamin K; C025667:prothrombin complex concentrates; C103587:recombinant FVIIa; D015942:Factor VIIa; D013917:Thrombin; D003894:Deamino Arginine Vasopressin; D000077425:Fondaparinux; C421124:drotrecogin alfa activated