[CX3CR1 polymorphism in patients with dilated cardiomyopathy].
OBJECTIVE
To investigate the association between CX3CR1 gene polymorphism and dilated cardiomyopathy (DCM).


METHODS
Two single nucleotide polymorphisms (SNP) rs3732378 (V249I) and rs3732379(T280M) in CX3CR1 gene were determined using PCR-RFLP. The frequencies of genotype and allele of these two SNPs were compared between 211 DCM patients and 211 normal controls.


RESULTS
The genotype distribution of these two SNPs had no deviation from Hardy-Weinberg equilibrium either in DCM patients or in the controls. No significant difference was found in the frequencies of genotype and allele in rs3732378 and rs3732379 between the DCM patients and the controls.


CONCLUSIONS
CX3CR1 gene polymorphism is not associated with DCM.
He
Xing-qiu
XQ
Departmentof Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang
Yan-yun
YY
Zhou
Bin
B
Rao
Li
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D000073883:CX3C Chemokine Receptor 1; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D019707:Receptors, Chemokine / Q000235:genetics*; D055815:Young Adult
D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine