The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects.
OBJECTIVE
Significant interest has emerged in the design of cell scaffolds that incorporate peptide sequences that correspond to known signaling domains in extracellular matrix and bone morphogenetic protein. The purpose of this study was to evaluate the bone regenerative effects of the synthetic peptide in a critical-size rat calvarial defect model.


METHODS
Eight millimeter diameter standardized, circular, transosseus defects created on the cranium of forty rats were implanted with synthetic peptide, collagen, or both synthetic peptide and collagen. No material was was implanted the control group. The healing of each group was evaluated histologically and histomorphometrically after 2- and 8-week healing intervals.


RESULTS
Surgical implantation of the synthetic peptide and collagen resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. When the experimental groups were compared to each other, they showed a similar pattern of bone formation. The defect closure and new bone area were significantly different in synthetic peptide and collagen group at 8 weeks.


CONCLUSIONS
Concerning the advantages of biomaterials, synthetic peptide can be an effective biomaterial for damaged periodontal regeneration.
Choi
Jung-Yoo
JY
Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
Jung
Ui-Won
UW
Kim
Chang-Sung
CS
Eom
Tae-Kwan
TK
Kang
Eun-Jung
EJ
Cho
Kyoo-Sung
KS
Kim
Chong-Kwan
CK
Choi
Seong-Ho
SH