title: Polyoxazoline thermoresponsive micelles as radionuclide delivery systems.
abstract: Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5-10 × 10(-5) g · mL(-1) with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.
authors.affiliation: Institute of Macromolecular Chemistry, v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. mhruby@centrum.cz
authors.forename: Martin
authors.initials: M
authors.lastname: Hruby
authors.forename: Sergey K
authors.initials: SK
authors.lastname: Filippov
authors.forename: Jiri
authors.initials: J
authors.lastname: Panek
authors.forename: Michaela
authors.initials: M
authors.lastname: Novakova
authors.forename: Hana
authors.initials: H
authors.lastname: Mackova
authors.forename: Jan
authors.initials: J
authors.lastname: Kucka
authors.forename: David
authors.initials: D
authors.lastname: Vetvicka
authors.forename: Karel
authors.initials: K
authors.lastname: Ulbrich
mesh_terms: D006461:Hemolysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008970:Molecular Weight; D010080:Oxazoles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011868:Radioisotopes / Q000008:administration & dosage*; D013696:Temperature
chemical_list: D008823:Micelles; D010080:Oxazoles; D011108:Polymers; D011868:Radioisotopes; C555801:poly(2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline)