Effect of Pro-Leu-Gly-NH(2) on plasma levels of ?-MSH in the rat.
With the idea to give further support that Pro-Leu-Gly-NH(2) (PLG) acts as MIF (the inhibitor factor of MSH), this paper reports the effect of PLG on the secretion of MSH release using a recently developed radioimmunoassay for ?-MSH. Pro-Leu-Gly-NH(2) was effective in inhibiting the release of MSH induced by the injection of acid extracts of median eminence (MRF). The rise in plasma MSH by these extracts was not due to their intrinsic content of MSH. Pro-Leu-Gly-NH(2) also inhibited the basal secretion of MSH in male rats. Since PLG also blocked the release of MSH induced by the injection of haloperidol, it is suggested that its effect is not mediated by dopamine.
Celis
M E
ME
Wellcome Laboratories for Research into Skin Diseases, Department of Dermatology, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.
Thody
A J
AJ
Fisher
C
C