[Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation].
OBJECTIVE
To evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation (OGD).


METHODS
A pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model.


RESULTS
Polydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells.


CONCLUSIONS
Polydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.
Xu
Bing
B
Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Lin
Huan-bing
HB
Zhou
Heng
H
Xu
Jiang-ping
JP
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000517:prevention & control; D002470:Cell Survival; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D009569:Nitric Oxide / Q000032:analysis; D010100:Oxygen / Q000378:metabolism* / Q000494:pharmacology; D016716:PC12 Cells; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D005960:Glucosides; D020011:Protective Agents; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005947:Glucose; D010100:Oxygen; C058229:polydatin