[Endothelin-1 and brain natriuretic peptide in the development of pulmonary hypertension in interstitial lung diseases].
OBJECTIVE
To study the plasma concentration of brain natriuretic peptide (BNP) and endothelin-1 (ET-1) as markers of pulmonary hypertension (PH) developed in interstitial lung diseases (ILD).


METHODS
Along with physical examination, 97 patients with ILD underwent measurements of the plasma concentrations of BNP and ET-1, 6-minute walk test, external respiration function test, echocardiography, by measuring pulmonary artery systolic pressure (P(syst)), and chest multispiral computed tomography, by estimating the mean diameter of the pulmonary artery trunk.


RESULTS
The plasma concentration of ET-1 proved to be significantly higher in the presence of active lung lesion (5.2 +/- 3.9 and 2.8 +/- 1.8 pg/ml; p = 0.0001). In patients with ILD, persistent PH was associated with the significantly elevated plasma concentrations of BNP (69.3 +/- 341.35 and 23.7 +/- 26.69 pg/ml; p = 0.018). The increase of plasma BNP concentrations correlated with the shorter distance covered during a 6-minute walk test and diminished functional vital capacity.


CONCLUSIONS
The increased plasma levels of ET-1 in ILD reflects the transient pulmonary artery pressure elevation associated with the activity of the pulmonary process while those of BNP are indicative of developed persistent PH.
Fomin
V V
VV
Popova
E N
EN
Kuznetsova
A V
AV
Popova
I A
IA
Churganova
L Iu
LIu
Osipenko
V I
VI
Mukhin
N A
NA
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000209:etiology*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; D019332:Endothelin-1; D020097:Natriuretic Peptide, Brain