title: Allergy and glioma risk: test of association by genotype.
abstract: Although epidemiological studies have suggested an association between atopy and glioma risk, these observations have been based on self-reporting of allergic conditions raising the possibility that associations may be noncausal and arise as a consequence of bias, reverse causation or other artifacts. Genetic information provides an alternative approach to investigate the relationship avoiding such biases. We analyzed 1,878 glioma cases and 3,670 controls for variants at 2q12, 5q12.1, 11q13 and 17q21 that are associated with asthma or eczema risk at p < 5.0 × 10(-7) . The SNP rs7216389, which tags the 3' flanking region of ORMDL3 at 17q21 and has been associated with childhood asthma, was correlated with increased glioma risk (OR = 1.10; 95% CI: 1.01-1.19). These data provide evidence for a correlation between asthma susceptibility and glioma risk and illustrate the value of using genetics as an investigative tool for developing etiological hypotheses.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Dobbins
authors.forename: Fay J
authors.initials: FJ
authors.lastname: Hosking
authors.forename: Sanjay
authors.initials: S
authors.lastname: Shete
authors.forename: Georgina
authors.initials: G
authors.lastname: Armstrong
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Robert
authors.initials: R
authors.lastname: Yu
authors.forename: Ching
authors.initials: C
authors.lastname: Lau
authors.forename: Minouk J
authors.initials: MJ
authors.lastname: Schoemaker
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Hepworth
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D000483:Alleles; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics*; D004485:Eczema; D005819:Genetic Markers; D005838:Genotype; D005910:Glioma / Q000150:complications / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D005819:Genetic Markers