The mouse retina as an angiogenesis model.
The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse retina and a discussion of some of the most widely used vascular disease models. From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis.
Stahl
Andreas
A
Department of Ophthalmology, Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
Connor
Kip M
KM
Sapieha
Przemyslaw
P
Chen
Jing
J
Dennison
Roberta J
RJ
Krah
Nathan M
NM
Seaward
Molly R
MR
Willett
Keirnan L
KL
Aderman
Christopher M
CM
Guerin
Karen I
KI
Hua
Jing
J
Löfqvist
Chatarina
C
Hellström
Ann
A
Smith
Lois E H
LE
D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D018919:Neovascularization, Physiologic / Q000502:physiology*; D015861:Retinal Neovascularization / Q000503:physiopathology*; D012171:Retinal Vessels / Q000502:physiology*