title: Neuropeptide Release is Impaired in a Mouse Model of Fragile X Mental Retardation Syndrome.
abstract: Fragile X syndrome (FXS), an inherited disorder characterized by mental retardation and autismlike behaviors, is caused by the failure to transcribe the gene for fragile X mental retardation protein (FMRP), a translational regulator and transporter of select mRNAs. FXS model mice (Fmr1 KO mice) exhibit impaired neuropeptide release. Release of biogenic amines does not differ between wild-type (WT) and Fmr1 KO mice. Rab3A, an mRNA cargo of FMRP involved in the recruitment of vesicles, is decreased by ∼50% in synaptoneurosomes of Fmr1 KO mice; however, the number of dense-core vesicles (DCVs) does not differ between WT and Fmr1 KO mice. Therefore, deficits associated with FXS may reflect this aberrant vesicle release, specifically involving docking and fusion of peptidergic DCVs, and may lead to defective maturation/maintenance of synaptic connections.
authors.affiliation: Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Annangudi
authors.forename: Agatha E
authors.initials: AE
authors.lastname: Luszpak
authors.forename: Soong Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Shifang
authors.initials: S
authors.lastname: Ren
authors.forename: Nathan G
authors.initials: NG
authors.lastname: Hatcher
authors.forename: Ivan Jeanne
authors.initials: IJ
authors.lastname: Weiler
authors.forename: Keith T
authors.initials: KT
authors.lastname: Thornley
authors.forename: Brian M
authors.initials: BM
authors.lastname: Kile
authors.forename: R Mark
authors.initials: RM
authors.lastname: Wightman
authors.forename: William T
authors.initials: WT
authors.lastname: Greenough
authors.forename: Jonathan V
authors.initials: JV
authors.lastname: Sweedler