[The damaging role of endogenous nitric oxide in the development of the experimental DSS-induced colitis in rats].
An experimental study on rats to determine the role of inducible NO production in the pathogenesis of inflammation of the mucous membrane of the colon. The introduction of DSS induces the formation of lesions of the colon mucosa of different severity, which is accompanied by increased synthesis of NO and the stable metabolite of NO - citrulline. Inhibition of NO-synthase reduces the release of NO and the formation of lesions of the colon. The Conduct of experimental research on animals will allow further study of the role of NO in the dynamics of damage development and the medication protective role of inhibition of NO-synthase.
Trubitsyna
I E
IE
Drozdov
V N
VN
Baryshnikov
E N
EN
Chikunova
B Z
BZ
Petrakov
A V
AV
D000818:Animals; D002956:Citrulline / Q000378:metabolism; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000378:metabolism / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D051381:Rats
D002956:Citrulline; D009569:Nitric Oxide; D016264:Dextran Sulfate; D019001:Nitric Oxide Synthase