A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis.
Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.
Lopes
Livia Cristina Liporagi
LC
Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Guimarães
Allan J
AJ
de Cerqueira
Mariana Duarte
MD
Gómez
Beatriz L
BL
Nosanchuk
Joshua D
JD
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D006658:Histoplasma / Q000187:drug effects / Q000254:growth & development / Q000276:immunology*; D006660:Histoplasmosis / Q000188:drug therapy* / Q000276:immunology; D054884:Host-Pathogen Interactions; D007074:Immunoglobulin G; D007167:Immunotherapy / Q000379:methods; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D015996:Survival Rate; D017211:Treatment Failure
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D008565:Membrane Proteins