title: Pax2 is expressed in a subpopulation of Müller cells in the central chick retina.
abstract: Müller cells in the chick retina are generally thought to be a homogeneous population. We show that the transcription factor Pax2 is expressed by Müller cells in the central chick retina and its expression was first observed at stage 32 (embryonic day [E] 7.5). Birth-dating indicated that the majority of Pax2-positive Müller cells are generated between stage 29 and 33 (E5.5-E8). At stage 42 (E16), several Müller cell markers, such as Sox2 and 2M6, had reached the peripheral retina, while the Pax2 labeling extended approximately half-way. A similar pattern was maintained in the 6-month-old chicken. Neither the Pax2-positive nor the Pax2-negative Müller cells could be specifically associated to proliferative responses in the retina induced by growth factors or N-methyl-D-aspartate. Pax2 was not detected in Müller cells in mouse, rat, guinea-pig, rabbit, or pig retinas; but the zebrafish retina displayed a similar pattern of central Pax2-expressing Müller cells.
authors.affiliation: Department of Neuroscience, Biomedical Centre, Uppsala University, Uppsala, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Boije
authors.forename: Henrik
authors.initials: H
authors.lastname: Ring
authors.forename: Meritxell
authors.initials: M
authors.lastname: López-Gallardo
authors.forename: Carmen
authors.initials: C
authors.lastname: Prada
authors.forename: Finn
authors.initials: F
authors.lastname: Hallböök
mesh_terms: D000818:Animals; D002477:Cells; D002642:Chick Embryo; D026603:D-Aspartic Acid / Q000378:metabolism; D004625:Embryo, Nonmammalian; D016202:N-Methylaspartate / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism*; D051762:PAX2 Transcription Factor / Q000378:metabolism*; D012160:Retina / Q000196:embryology / Q000378:metabolism / Q000502:physiology
chemical_list: D051762:PAX2 Transcription Factor; D026603:D-Aspartic Acid; D016202:N-Methylaspartate