title: [Clinical-pathological characteristics of IgM nephropathy in 34 children].
abstract: OBJECTIVE
  To investigate the clinical pathologic characteristics of IgM nephropathy in children.
  
  
  METHODS
  The data of 34 children with IgM nephropathy from the First Affiliated Hospital of Zhengzhou University were retrospectively reviewed.
  
  
  RESULTS
  Of the 34 cases of IgM nephropathy, nephrotic syndrome (NS) was clinically presented in 22 cases (64.7%). The renal pathological classification was as follows: minimal change disease (12 cases, 35.3%), minimal change disease with acute renal tubular injury (3 cases, 8.8%), minimal change glomerulonephritis (6 cases, 17.6%), minimal change glomerulernephritis with ischemic renal injury (1 case, 2.9%), mesangial proliferative glomerulonephritis (7 cases, 20.6%), focal segmental glomerulosclerosis (4 cases, 11.8%), focal proliferative glomerulernephritis (1 case, 2.9 %). Glomerular injury score, renal vascular injury score and total renal injury score increased with the increasing IgM deposition.
  
  
  CONCLUSIONS
  The majority of children with IgM nephropathy manifest clinically as nephrotic syndrome. The patterns of renal pathology may be varied in children with IgM nephropathy. IgM deposition in the mesenteric area is an important pathologic feature and is related to the degree of renal injury.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zheng
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Jian-Jiang
authors.initials: JJ
authors.lastname: Zhang
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D007075:Immunoglobulin M