title: [The processes of cell renewal in H. pylori-associated chronic atrophic gastritis].
abstract: OBJECTIVE
  To evaluate the expression of Ki-67 protein in stomach mucosa in H. pylori-associated chronic atrophic gastritis according to the stage of atrophy.
  
  
  METHODS
  The immunohistochemical and histological study of gastric mucosal biopsies from dyspeptic patients was performed. The new international system of gastric musocal atrophy staging (OLGA) was used.
  
  
  RESULTS
  The rates of cellular proliferation increase along the rising of the stage of stomach mucosal atrophy in Hpylori-associated chronic atrophic gastritis.
  
  
  CONCLUSIONS
  In H. pylori-associated chronic atrophic gastritis, the acceleration of the cellular renewal was revealed, proportional to a stage of gastric mucosal atrophy that implies the increase of risk of development of precancerous changes.
authors.forename: V D
authors.initials: VD
authors.lastname: Pasechnikov
authors.forename: A V
authors.initials: AV
authors.lastname: Balabekov
authors.forename: S Z
authors.initials: SZ
authors.lastname: Churkov
mesh_terms: D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005757:Gastritis, Atrophic / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D005786:Gene Expression Regulation; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D011230:Precancerous Conditions / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*
chemical_list: D019394:Ki-67 Antigen