title: CD56-negative extranodal nasal type NK/T-cell lymphoma.
abstract: Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare lymphoma that occurs predominantly in Asian adults. In this report, we describe the clinical and pathologic features of an unusual aggressive lymphoid neoplasm in a child and review the literature on NK/T-cell lymphoma in children. The patient was a 4-year-old Native American male with facial swelling, lymphadenopathy, and fevers. Biopsy demonstrated neoplastic lymphoid cells that expressed CD3, CD8, TIA-1, and EBV-encoded RNA without CD56. The patient failed multiagent chemotherapy and died of therapy-related complications. This case represents an extranodal NK/T-cell lymphoma, nasal type, with an unusual lack of CD56.
authors.affiliation: Department of Pathology, University of Utah, Salt Lake City, Utah 84112, USA. rodney.miles@path.utah.edu
authors.forename: Rodney R
authors.initials: RR
authors.lastname: Miles
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Afify
authors.forename: Hassan
authors.initials: H
authors.lastname: Yaish
authors.forename: Sherrie L
authors.initials: SL
authors.lastname: Perkins
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019002:CD56 Antigen / Q000096:biosynthesis; D002675:Child, Preschool; D017809:Fatal Outcome; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male
chemical_list: D019002:CD56 Antigen