Four new sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric-oxide production.
Four new sesquiterpenes including the novel sesquiterpene lactone (6R)-dehydroxysipanolinolide (1), two new eudesmane-type sesquiterpenes, curcolide (2) and curcodione (3), and a new xanthane-type sesquiterpene, curcumadionol (4), were isolated from Curcuma wenyujin Y. H. Chen et C. Ling, together with five known ones, 5-9. The structures of the new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1-9 on nitric-oxide production in lipopolysaccaride-activated macrophages were evaluated.
Lou
Yan
Y
Department of Natural Products Chemistry 81#, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Road WenHua, Shenyang 110016, P. R. China.
Zhao
Feng
F
He
Hao
H
Peng
Kai-Feng
KF
Chen
Li-Xia
LX
Qiu
Feng
F
D000818:Animals; D045744:Cell Line, Tumor; D030024:Curcuma / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D012717:Sesquiterpenes; D009569:Nitric Oxide