HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.
BACKGROUND
We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women.


METHODS
A total of 119 patients with invasive cervical squamous cell carcinoma were compared to 119 age- and menopausal status-matched non-cancer controls. Blood samples were taken from all cases and controls and lifestyle information was collected by means of a self-administered questionnaire. The estimated impact of HLA-A alleles on cervical cancer risk was evaluated by unconditional logistic regression models.


RESULTS
The frequency of HLA-A(*)0206 among cases was significantly lower than among controls (P = 0.006). There was an inverse association between A(*)0206 and cervical cancer risk (odds ratio [OR] = 0.31, 95% confidence interval [95% CI] = 0.15 to 0.65, P = 0.002), and a positive association for HLA-A(*)2402 (OR = 1.76, 95% CI = 1.00 to 3.09, P = 0.048). After correction for multiple comparisons, A(*)0206 was significantly associated with reduced cervical cancer risk (corrected P = 0.036). Furthermore, the inverse association between A(*)0206 and cervical cancer risk was independent of smoking status (never smoker: OR = 0.37, 95% CI = 0.15 to 0.90; ever smoker: OR = 0.23, 95% CI = 0.06 to 0.89).


CONCLUSIONS
There was an inverse association between HLA-A(*)0206 and cervical cancer risk among Japanese women, which suggests that HLA-A polymorphism influences cervical cancer risk. Further investigation in other populations is thus warranted.
Hosono
Satoyo
S
Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kawase
Takakazu
T
Matsuo
Keitaro
K
Watanabe
Miki
M
Kajiyama
Hiroaki
H
Hirose
Kaoru
K
Suzuki
Takeshi
T
Kidokoro
Kumiko
K
Ito
Hidemi
H
Nakanishi
Toru
T
Yatabe
Yasushi
Y
Hamajima
Nobuyuki
N
Kikkawa
Fumitaka
F
Tajima
Kazuo
K
Tanaka
Hideo
H
D000328:Adult; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
D015234:HLA-A Antigens