Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors.
BACKGROUND
Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines.


OBJECTIVE
The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors.


METHODS
The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively.


RESULTS
We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected].


CONCLUSIONS
The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion.
Meyer
Thomas
T
Department of Psychosomatic Medicine and Psychotherapy, von-Siebold-Str. 5, D-37075 Göttingen, Germany.
Stanske
Beate
B
Kochen
Michael M
MM
Cordes
Andreas
A
Yüksel
Iraz
I
Wachter
Rolf
R
Lüers
Claus
C
Scherer
Martin
M
Binder
Lutz
L
Pieske
Burkert
B
Herrmann-Lingen
Christoph
C
D000368:Aged; D001317:Austria; D002318:Cardiovascular Diseases / Q000235:genetics / Q000276:immunology* / Q000523:psychology*; D015331:Cohort Studies; D003327:Coronary Disease / Q000235:genetics / Q000276:immunology / Q000523:psychology; D005221:Fatigue / Q000235:genetics / Q000276:immunology* / Q000523:psychology*; D005260:Female; D006333:Heart Failure / Q000235:genetics / Q000276:immunology / Q000523:psychology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D007508:Irritable Mood / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009013:Morale; D010555:Personality Inventory / Q000706:statistics & numerical data; D011320:Primary Health Care; D011594:Psychometrics; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10