title: [Research on a novel method for the evaluation of left ventricular diastolic function].
abstract: The methods for evaluating left ventricular diastolic function completely and simply are lacking in our country at present. To solve this problem, we presents in this paper a novel method, which is developed according to certain algorithms and mathematic models and is carried out by a MATLAB program. This method mainly obtains dP/dt loops, and calculates four important indices, including left ventricular end-diastolic pressure (LVEDP), Maximal decrease in velocity of left ventricular pressure (--(dP/dt)max), Time constant of ventricular isovolumic relaxation (tau) and Chamber stiffness (Kd), according to the changes of left ventricular pressure. The results obtained from the experiment of isolated rat hearts during ischemia/reperfusion have demonstrated the usefulness and validity of this method. Therefore, with the use of tau and Kd as indicators, this is a sensitive and effective method for evaluating the left ventricular diastolic function, and it can be applied to early detection of left ventricular diastolic dysfunction.
authors.affiliation: Zhejiang University School of Medicine, National Education Base for Basic Medical Sciences, Hangzhou 310058, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ou
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Zheng
authors.forename: Jiali
authors.initials: J
authors.lastname: Bao
authors.forename: Yingying
authors.initials: Y
authors.lastname: Chen
authors.forename: Yueliang
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000465:Algorithms; D000818:Animals; D001794:Blood Pressure; D003971:Diastole; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008955:Models, Cardiovascular; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*