Characteristics of lipo-oligosaccharide loci of Campylobacter jejuni isolates associated with Guillain-Barré Syndrome from Hebei, China.
Ganglioside mimicry by C.jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.
Jiang
Hai
H
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China. jianghai@icdc.cn
Zhang
Mao-Jun
MJ
Liu
Rui-Chun
RC
Tian
Xin-Ying
XY
Gu
Yi-Xin
YX
Zhang
Jian-Zhong
JZ
D001483:Base Sequence; D016123:Campylobacter jejuni / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D005798:Genes, Bacterial; D056426:Genetic Loci; D020275:Guillain-Barre Syndrome / Q000382:microbiology; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000096:biosynthesis / Q000235:genetics*
D008070:Lipopolysaccharides; D009844:Oligosaccharides