title: Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E - J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata.
abstract: In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects.
authors.affiliation: Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia.
authors.forename: David M
authors.initials: DM
authors.lastname: Pinkerton
authors.forename: Martin G
authors.initials: MG
authors.lastname: Banwell
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Garson
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
authors.forename: Manoel Odorico
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Cavalcanti
authors.forename: Francisco W A
authors.initials: FW
authors.lastname: Barros
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D031161:Pseudoalteromonas / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D003603:Cytotoxins; D011758:Pyrroles; C085612:BE 18591