Antimicrobial property, antioxidant capacity, and cytotoxicity of essential oil from cumin produced in Iran.
Cumin (Cuminum cyminum) is one of the commonly used spices in food preparations. It is also used in traditional medicine as a stimulant, a carminative, and an astringent. In this study, we characterized the antimicrobial, antioxidant, and cytotoxic activities of cumin. E. coli, S. aureus, and S. faecalis were sensitive to various oil dilutions. The total phenol content of the essential oil was estimated to be 33.43 microg GAE/mg of the oil. The oil showed higher antioxidant activity compared with that of BHT and BHA. The cumin essential oil exhibited a dose-dependent scavenging of DPPH radicals and 5.4 microg of the oil was sufficient to scavenge 50% of DPPH radicals/mL. At a concentration of 0.1 microL/mL, oil destructed Hela cells by 79%. The antioxidant activity of cumin essential oil might contribute to its cytotoxic activity. Acute and subchronic toxicity was studied in a 30-d oral toxicity study by administration to Wistar rats of the essential oil. A 17.38% decrease in WBCs count, and 25.77%, 14.24%, and 108.81% increase in hemoglobin concentration, hematocrit, and platelet count, respectively, were noted. LDL/HDL ratio was reduced to half, which adds to the nutritional effects of cumin. Thus, cumin with a high phenolic content and good antioxidant activity can be supplemented for both nutritional purposes and preservation of foods.
Allahghadri
Tolou
T
Dept. of Biology, Shahed Univ., Tehran-Qom Express Way, Opposite Imam Khomeini's shrine, Tehran 3319118651, Iran.
Rasooli
Iraj
I
Owlia
Parviz
P
Nadooshan
Mohammadreza Jalali
MJ
Ghazanfari
Tooba
T
Taghizadeh
Massoud
M
Astaneh
Shakiba Darvish Alipoor
SD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001773:Blood Cells / Q000187:drug effects; D028527:Cuminum / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006454:Hemoglobins / Q000187:drug effects; D006801:Humans; D007492:Iran; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D006454:Hemoglobins; D010938:Plant Oils