title: Functional cine MRI and transabdominal ultrasonography for the assessment of adhesions to implanted synthetic mesh 5-7 years after laparoscopic ventral hernia repair.
abstract: BACKGROUND
  Laparoscopic ventral hernia repair (LVHR) has gained worldwide acceptance, due to its minimally invasive character, feasibility and low rate of complications. Animal experiments have shown marked adhesions to the intraperitoneal mesh (IPM), the clinical consequences being unclear. This study aimed to describe the extension of adhesions to the mesh, 5-7 years after LVHR, using two validated non-invasive radiologic methods.
  
  
  METHODS
  Real-time transabdominal ultrasonography (TAU) and cine magnetic resonance imaging (MRI) was applied to 30 patients with prior LVHR and implantation of IPM (Intramesh W3, Cousin Biotech, France). The visceral slide was measured in nine predefined abdominal segments. Values <or=1 cm were defined as an area with adhesion.
  
  
  RESULTS
  The mean time between LVHR and TAU/cine MRI was 67 months (range, 58-80 months). We found adhesion to the mesh in 90% of the patients using TAU and 100% of the patients using cine MRI. In the latter, 65% were between the bowel and IPM.
  
  
  CONCLUSIONS
  LVHR is known to reduce recurrences and postoperative complications, while improving patient outcome. The intraperitoneal placement of the mesh has been shown to induce adhesions; the amount and extension in the clinical setting is unclear. The present study showed a marked proportion of adhesions to the mesh with an average surgery to scan time of 5.6 years, despite an anti-adhesive barrier on the visceral surface of the mesh. Together with existing data, this result increases the concern related to the long-term consequences of an IPM. As a consequence, a comprehensive and comparable test system for medical devices, i.e. IPM, is needed.
authors.affiliation: Surgical Department, Horsens Regional Hospital, Horsens, Denmark. nellie@zinther.dk
authors.forename: N B
authors.initials: NB
authors.lastname: Zinther
authors.forename: A
authors.initials: A
authors.lastname: Zeuten
authors.forename: E
authors.initials: E
authors.lastname: Marinovskij
authors.forename: M
authors.initials: M
authors.lastname: Haislund
authors.forename: P
authors.initials: P
authors.lastname: Wara
authors.forename: H
authors.initials: H
authors.lastname: Friis-Andersen
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006555:Hernia, Ventral / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene / Q000009:adverse effects*; D012189:Retrospective Studies; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000175:diagnosis* / Q000209:etiology; D014463:Ultrasonography
chemical_list: D011138:Polytetrafluoroethylene