title: Study of the stabilization of zinc phthalocyanine in sol-gel TiO2 for photodynamic therapy applications.
abstract: Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer. It is a two-step procedure that uses a combination of molecular oxygen, visible light, and photosensitizer (PS) agents; phthalocyanine (Pc) was supported over titanium oxide but has not yet been used for cell inactivation. Zinc phthalocyanine (ZnPc) molecules were incorporated into the porous network of titanium dioxide (TiO(2)) using the sol-gel method. It was prepared from stock solutions of ZnPc and TiO(2). ZnPc-TiO(2) was tested with four cancer cell lines. The characterization of supported ZnPc showed that phthalocyanine is linked by the N-pyrrole to the support and is stable up to 250°C, leading to testing for PDT. The preferential localization in target organelles such as mitochondria or lysosomes could determine the cell death mechanism after PDT. The results suggest that nanoparticulated TiO(2) sensitized with ZnPc is an excellent candidate as sensitizer in PDT against cancer and infectious diseases.
authors.affiliation: Universidad Autónoma Metropolitana, Departamento de Atención a la Salud, México.
authors.forename: Tessy
authors.initials: T
authors.lastname: Lopez
authors.forename: Ema
authors.initials: E
authors.lastname: Ortiz
authors.forename: Mayra
authors.initials: M
authors.lastname: Alvarez
authors.forename: Juan
authors.initials: J
authors.lastname: Navarrete
authors.forename: Jose A
authors.initials: JA
authors.lastname: Odriozola
authors.forename: Fernando
authors.initials: F
authors.lastname: Martinez-Ortega
authors.forename: Edgar A
authors.initials: EA
authors.lastname: Páez-Mozo
authors.forename: Patricia
authors.initials: P
authors.lastname: Escobar
authors.forename: Karla A
authors.initials: KA
authors.lastname: Espinoza
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Rivero
mesh_terms: D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D008027:Light; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D014025:Titanium / Q000737:chemistry*; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; C009495:titanium dioxide; D014025:Titanium; D010100:Oxygen; C013647:phthalocyanine