title: [A case of gastric large cell neuroendocrine carcinoma (LCNEC) for whom chemotherapy of CDDP+CPT-11 proved very effective].
abstract: Large cell neuroendocrine carcinoma(LCNEC)is a relatively new category with biological behavior similar to small cell carcinoma. Thus, it is reportedly well treated by the same chemotherapy as for small cell carcinoma. We experienced a case of gastric large cell neuroendocrine carcinoma, treated very effectively by CDDP+CPT-11.60 mg/m(2) of CDDP was administered on day 1, and 60 mg/m(2) of CPT-11 on day 1, 8 and 15. An intermission after administration for 14 days made for one course. Four courses were carried out. A complete response was obtained for a primary gastric lesion and liver metastasis, and a partial response was obtained for lymph node metastases. So far it has showed no change for 6 months after chemotherapy. Both CDDP and CPT-11 are key drugs in the chemotherapy for common gastric cancer, and it is sometimes difficult to distinguish large cell neuroendocrine carcinoma from poorly-differentiated gastric cancer. We found this combination chemotherapy is a suitable regimen for the assumed existence of large cell neuroendocrine carcinoma at the gastric lesion.
authors.affiliation: Dept. of Surgery, Hata General Hospital.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kirii
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ichikawa
authors.forename: Masatake
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Hata
authors.forename: Junichi
authors.initials: J
authors.lastname: Miyairi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takagi
authors.forename: Mana
authors.initials: M
authors.lastname: Fukushima
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Ota
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000188:drug therapy*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005773:Gastroscopy; D006801:Humans; D000077146:Irinotecan; D008297:Male; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin