Pediatric obstructive sleep apnea syndrome.
Obstructive sleep apnea syndrome (OSAS) is a common and serious cause of metabolic, cardiovascular, and neurocognitive morbidity in children. Children with OSAS have increased upper airway resistance during sleep due to a combination of soft tissue hypertrophy, craniofacial dysmorphology, neuromuscular weakness, or obesity. Consequently, children with OSAS encounter a combination of oxidative stress, inflammation, autonomic activation, and disruption of sleep homeostasis. The threshold amount of OSAS associated with adverse consequences varies widely among children, depending on genetic and environmental factors. The choice of therapy is predicated on the etiology, severity, and natural history of the increased upper airway resistance.
Katz
Eliot S
ES
Division of Respiratory Diseases, Department of Medicine, Children's Hospital, Mailstop 208, 300 Longwood Avenue, Boston, MA 02115, USA. eliot.katz@childrens.harvard.edu
D'Ambrosio
Carolyn M
CM
D000233:Adenoidectomy; D001794:Blood Pressure / Q000502:physiology; D002319:Cardiovascular System / Q000503:physiopathology; D002648:Child; D006801:Humans; D024821:Metabolic Syndrome / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology; D018384:Oxidative Stress; D010808:Physical Examination; D017286:Polysomnography; D015656:Respiratory Mechanics; D012132:Respiratory Muscles / Q000503:physiopathology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D014068:Tonsillectomy