title: Factors influencing subjective quality of life in patients with schizophrenia and other mental disorders: a pooled analysis.
abstract: Subjective quality of life (SQOL) is an important outcome in the treatment of patients with schizophrenia. However, there is only limited evidence on factors influencing SQOL, and little is known about whether the same factors influence SQOL in patients with schizophrenia and other mental disorders. This study aimed to identify the factors associated with SQOL and test whether these factors are equally important in schizophrenia and other disorders. For this we used a pooled data set obtained from 16 studies that had used either the Lancashire Quality of Life Profile or the Manchester Short Assessment of Quality of Life for assessing SQOL. The sample comprised 3936 patients with schizophrenia, mood disorders, and neurotic disorders. After controlling for confounding factors, within-subject clustering, and heterogeneity of findings across studies in linear mixed models, patients with schizophrenia had more favourable SQOL scores than those with mood and neurotic disorders. In all diagnostic groups, older patients, those in employment, and those with lower symptom scores had higher SQOL scores. Whilst the strength of the association between age and SQOL did not differ across diagnostic groups, symptom levels were more strongly associated with SQOL in neurotic than in mood disorders and schizophrenia. The association of employment and SQOL was stronger in mood and neurotic disorders than in schizophrenia. The findings may inform the use and interpretation of SQOL data for patients with schizophrenia.
authors.affiliation: Unit for Social and Community Psychiatry, Barts and the London School of Medicine, Queen Mary University of London, London, UK. S.Priebe@qmul.ac.uk
authors.forename: Stefan
authors.initials: S
authors.lastname: Priebe
authors.forename: Ulrich
authors.initials: U
authors.lastname: Reininghaus
authors.forename: Rosemarie
authors.initials: R
authors.lastname: McCabe
authors.forename: Tom
authors.initials: T
authors.lastname: Burns
authors.forename: Mona
authors.initials: M
authors.lastname: Eklund
authors.forename: Lars
authors.initials: L
authors.lastname: Hansson
authors.forename: Ulrich
authors.initials: U
authors.lastname: Junghan
authors.forename: Thomas
authors.initials: T
authors.lastname: Kallert
authors.forename: Chijs
authors.initials: C
authors.lastname: van Nieuwenhuizen
authors.forename: Mirella
authors.initials: M
authors.lastname: Ruggeri
authors.forename: Mike
authors.initials: M
authors.lastname: Slade
authors.forename: Duolao
authors.initials: D
authors.lastname: Wang
mesh_terms: D000328:Adult; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012559:Schizophrenia / Q000175:diagnosis; D012565:Schizophrenic Psychology