Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group.
We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberrant karyotype, 53% were complex, and 29% had a single aberration. The predominant aberrations were gains of 3/3q and 12q, deletions of 7q and 6q and translocations involving 8q/1q/14q. CD5 expression was detected in 39 of 158 cases (25%). The cytogenetic makeup of the CD5(+) group differed significantly from that of the CD5(-) group. Cases with unmutated IGHV were significantly associated with deletions of 7q and TP53. A strong association was noted between usage of the IGVH1-2 and deletion 7q, 14q alterations, and abnormal karyotype. On univariate analysis, patients with more than or equal to 2 aberrations, 14q alterations, and TP53 deletions had the shortest survival; 7q deletion did not affect survival. On multivariate analysis, cytogenetic aberrations did not retain prognostic significance; the parameters negatively affecting survival were hemoglobin and age. In conclusion, the cytogenetic profile of SMZL is distinct from other B-cell lymphomas. Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL.
Salido
Marta
M
Hospital del Mar, IMAS, Barcelona, Spain.
Baró
Cristina
C
Oscier
David
D
Stamatopoulos
Kostas
K
Dierlamm
Judith
J
Matutes
Estela
E
Traverse-Glehen
Alexandra
A
Berger
Francoise
F
Felman
Pascale
P
Thieblemont
Catherine
C
Gesk
Stefan
S
Athanasiadou
Anastasia
A
Davis
Zadie
Z
Gardiner
Anne
A
Milla
Fuensanta
F
Ferrer
Ana
A
Mollejo
Manuela
M
Calasanz
Maria José
MJ
Florensa
Lourdes
L
Espinet
Blanca
B
Luño
Elisa
E
Wlodarska
Iwona
I
Verhoef
Gregor
G
García-Granero
Marta
M
Salar
Antonio
A
Papadaki
Theodora
T
Serrano
Sergio
S
Piris
Miguel A
MA
Solé
Francesc
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016158:Genes, p53; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D013160:Splenic Neoplasms / Q000235:genetics* / Q000473:pathology; D015996:Survival Rate
D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region