title: Stereochemical and skeletal diversity arising from amino propargylic alcohols.
abstract: An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pizzirani
authors.forename: Taner
authors.initials: T
authors.lastname: Kaya
authors.forename: Paul A
authors.initials: PA
authors.lastname: Clemons
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D006576:Heterocyclic Compounds, 4 or More Rings