Coordination polymer particles as potential drug delivery systems.
Micro- and nanoscale coordination polymer particles can be used for encapsulating and delivering drugs. In vitro cancer cell cytotoxicity assays showed that these capsules readily release doxorubicin, which shows anticancer efficacy. The results from this work open up new avenues for metal-organic capsules to be used as potential drug delivery systems.
Imaz
Inhar
I
Centro de Investigación en Nanociencia y Nanotecnología (ICN-CSIC) Campus UAB, 08193 Bellaterra, Spain.
Rubio-Martínez
Marta
M
García-Fernández
Lorena
L
García
Francisca
F
Ruiz-Molina
Daniel
D
Hernando
Jordi
J
Puntes
Victor
V
Maspoch
Daniel
D
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D018922:HL-60 Cells; D006801:Humans; D008670:Metals / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008670:Metals; D009930:Organic Chemicals; D011108:Polymers; D004317:Doxorubicin