Production, characterization, in vitro and ex vivo studies of babchi oil-encapsulated nanostructured solid lipid carriers produced by a hot aqueous titration method.
An aqueous dispersion of solid fat nanoparticles of babchi oil (BOSLN) was prepared by means of the hot water titration method. Surface morphology was determined by HR-TEM which revealed a fairly spherical shape of the formulations. Further they were evaluated for in vitro drug release characteristics and ex vivo skin permeation profile, zeta potential and particle diameter, rheological measures and droplet size distribution. Highest values for steady state flux (Jss), permeability coefficient (Kp) and enhancement ratio (Er) were observed for formulation, BOSLN3 comprised of oil [10% v/v; BO (3.33%), CAT (6.67%)], Tween 80 (9.25% v/v), transcutol-P (28.75% v/v) and distilled water (53% v/v). These results suggest that the studied SLN might be promising vehicles for babchi oil in the management of psoriasis.
Faiyazuddin
M
M
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Akhtar
N
N
Akhter
J
J
Suri
S
S
Shakeel
F
F
Shafiq
S
S
Mustafa
G
G
D000818:Animals; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D004337:Drug Carriers; D004339:Drug Compounding; D004356:Drug Storage; D004563:Electrochemistry; D004655:Emulsions; D007887:Fabaceae; D005363:Ficusin / Q000032:analysis; D008081:Liposomes; D053758:Nanoparticles; D010316:Particle Size; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D029907:Psoralea / Q000737:chemistry*; D011565:Psoriasis / Q000188:drug therapy; D051381:Rats; D012212:Rheology; D012869:Skin Absorption / Q000502:physiology; D013499:Surface Properties; D013501:Surface-Active Agents; D013696:Temperature; D013816:Thermodynamics
D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D017319:Photosensitizing Agents; D010938:Plant Oils; D013501:Surface-Active Agents; C550193:babchi oil; D005363:Ficusin