[The processes of cell renewal in H. pylori-associated chronic atrophic gastritis].
OBJECTIVE
To evaluate the expression of Ki-67 protein in stomach mucosa in H. pylori-associated chronic atrophic gastritis according to the stage of atrophy.


METHODS
The immunohistochemical and histological study of gastric mucosal biopsies from dyspeptic patients was performed. The new international system of gastric musocal atrophy staging (OLGA) was used.


RESULTS
The rates of cellular proliferation increase along the rising of the stage of stomach mucosal atrophy in Hpylori-associated chronic atrophic gastritis.


CONCLUSIONS
In H. pylori-associated chronic atrophic gastritis, the acceleration of the cellular renewal was revealed, proportional to a stage of gastric mucosal atrophy that implies the increase of risk of development of precancerous changes.
Pasechnikov
V D
VD
Balabekov
A V
AV
Churkov
S Z
SZ
D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005757:Gastritis, Atrophic / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D005786:Gene Expression Regulation; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D011230:Precancerous Conditions / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*
D019394:Ki-67 Antigen