Synthesis of pyrazolines by a site isolated resin-bound reagents methodology.
The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities.
Gembus
Vincent
V
CNRS UMR COBRA, INSA et Université de Rouen, FR 3038, IRCOF (Research Institute in Fine Organic Chemistry), rue Tesnière, BP 08, 76131 Mont Saint Aignan, France.
Bonnet
Jean-Jacques
JJ
Janin
François
F
Bohn
Pierre
P
Levacher
Vincent
V
Brière
Jean-François
JF
D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*
D007202:Indicators and Reagents; D011720:Pyrazoles; D012117:Resins, Synthetic; C031280:pyrazole