Calnuc: Emerging roles in calcium signaling and human diseases.
Calnuc is a recently discovered multidomain protein with EF-hand calcium binding sites. Several studies have reported various interacting partners for calnuc and, therefore, also different sites of localization in the cell. It interacts with important molecules such as DNA, G protein, COX, and amyloid precursor protein among others in addition to being involved in stress response and trafficking. The immense possibilities (of various functions this protein might be involved in) implicate great future in medicine and physiology. Preliminary studies also implicate the possibility of calnuc being involved in some of the human diseases. These initial observations imply the functions that this protein might be involved in. This review emphasizes the importance of further research on this protein.
Aradhyam
Gopala Krishna
GK
Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India. agk@iitm.ac.in
Balivada
Lavanya Madhuri
LM
Kanuru
Madhavi
M
Vadivel
Prabahar
P
Vidhya
Balasubramanian Shanthi
BS
D020013:Calcium Signaling; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004194:Disease; D006801:Humans; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins