title: Hybrid cardiopulmonary model for analysis of valsalva maneuver with radial artery pulse.
abstract: A comprehensive model, which has the advantages of both lumped parameter and distributed parameter, has been developed with the objective of investigating the respiratory influences in radial artery pressure pulse as in photoplethysmography (PPG). It integrates lumped parameter cardiopulmonary (CP) model and transmission line arterial tree model from aorta to radial artery. The cardio-pulmonary interaction is realized by incorporating respiratory-induced variations in intrapleural pressure (Ppl) in circulatory system. The PPG signal of the model is considered as the radial artery pulse. To investigate the interaction Valsalva Maneuver (VM) condition has been simulated for different Ppl magnitude (10, 20, 30, and 40 mmHg) and for different time duration (5, 10, 15, and 20 s), and validated with PPG signal recorded in 10 normal subjects performing VM. The effects of test duration and VM pressure are studied in both the simulation and the experiments with specific focus on the maximal (%∆) changes in Heart Rate (HR), and Mean Arterial Pressure (MAP) during phases II and IV of VM. The correlation coefficients derived from model result have good agreement with experimental results. As radial artery pulse plays important role in both allopathy and alternate medicine systems, this model can serve to study its clinical importance in detecting cardiac and respiratory pathologies.
authors.affiliation: MSB 207, Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai 600036, Tamilnadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Hemalatha
authors.forename: L
authors.initials: L
authors.lastname: Suganthi
authors.forename: M
authors.initials: M
authors.lastname: Manivannan
mesh_terms: D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D017156:Photoplethysmography / Q000379:methods; D035422:Pleural Cavity / Q000502:physiology; D017534:Radial Artery / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D014636:Valsalva Maneuver / Q000502:physiology*