Benzyne arylation of oxathiane glycosyl donors.
The arylation of bicyclic oxathiane glycosyl donors has been achieved using benzyne generated in situ from 1-aminobenzotriazole (1-ABT) and lead tetraacetate. Following sulfur arylation, glycosylation of acetate ions proceeded with high levels of stereoselectivity to afford α -glycosyl acetates in a 'one-pot' reaction, even in the presence of alternative acceptor alcohols.
Fascione
Martin A
MA
School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Turnbull
W Bruce
WB