title: Toward integrated management of cerebral aneurysms.
abstract: In the last few years, some of the visionary concepts behind the virtual physiological human began to be demonstrated on various clinical domains, showing great promise for improving healthcare management. In the current work, we provide an overview of image- and biomechanics-based techniques that, when put together, provide a patient-specific pipeline for the management of intracranial aneurysms. The derivation and subsequent integration of morphological, morphodynamic, haemodynamic and structural analyses allow us to extract patient-specific models and information from which diagnostic and prognostic descriptors can be obtained. Linking such new indices with relevant clinical events should bring new insights into the processes behind aneurysm genesis, growth and rupture. The development of techniques for modelling endovascular devices such as stents and coils allows the evaluation of alternative treatment scenarios before the intervention takes place and could also contribute to the understanding and improved design of more effective devices. A key element to facilitate the clinical take-up of all these developments is their comprehensive validation. Although a number of previously published results have shown the accuracy and robustness of individual components, further efforts should be directed to demonstrate the diagnostic and prognostic efficacy of these advanced tools through large-scale clinical trials.
authors.affiliation: Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Information and Communication Technologies Department, Universitat Pompeu Fabra, c/Tanger 122-140, 08018 Barcelona, Spain. cruz.villa@upf.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Villa-Uriol
authors.forename: I
authors.initials: I
authors.lastname: Larrabide
authors.forename: J M
authors.initials: JM
authors.lastname: Pozo
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: O
authors.initials: O
authors.lastname: Camara
authors.forename: M
authors.initials: M
authors.lastname: De Craene
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: A J
authors.initials: AJ
authors.lastname: Geers
authors.forename: H
authors.initials: H
authors.lastname: Morales
authors.forename: H
authors.initials: H
authors.lastname: Bogunović
authors.forename: R
authors.initials: R
authors.lastname: Cardenes
authors.forename: A F
authors.initials: AF
authors.lastname: Frangi
mesh_terms: D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000628:therapy; D001696:Biomechanical Phenomena; D002533:Cerebral Angiography; D003952:Diagnostic Imaging; D019468:Disease Management; D004864:Equipment and Supplies; D006439:Hemodynamics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D008953:Models, Anatomic; D008954:Models, Biological; D009068:Movement; D057285:Precision Medicine; D011379:Prognosis; D015607:Stents; D014584:User-Computer Interface