title: Cytotoxic terpenoids from Nardophyllum bryoides.
abstract: The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and ursane triterpenoids (6-11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound.
authors.affiliation: UMYMFOR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2-(1428), Buenos Aires, Argentina.
authors.forename: Marianela
authors.initials: M
authors.lastname: Sánchez
authors.forename: Marcia
authors.initials: M
authors.lastname: Mazzuca
authors.forename: María José
authors.initials: MJ
authors.lastname: Veloso
authors.forename: Lucía R
authors.initials: LR
authors.lastname: Fernández
authors.forename: Gastón
authors.initials: G
authors.lastname: Siless
authors.forename: Lydia
authors.initials: L
authors.lastname: Puricelli
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Palermo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001118:Argentina; D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D013729:Terpenes; D009828:Oleanolic Acid