Bone mineral density in HIV-infected women taking antiretroviral therapy: a systematic review.
There is a high prevalence of osteoporosis in HIV-infected patients. Initially described in HIV-positive men, studies have also demonstrated a high prevalence of osteoporosis in HIV-infected women. It would appear that antiretroviral therapy (ART) plays an important role in the pathogenesis of osteoporosis in HIV-infected patients, although little is known about its importance in relation to osteoporosis and fractures in HIV-positive women. The aim of this systematic review was to evaluate the frequency of bone loss, bone mineral density (BMD) and fractures in HIV-positive women taking ART or protease inhibitors (PI). After screening 597 citations from the databases of PubMed, EMBASE and Lilacs, five studies were selected for the review. A difference was demonstrated of over 3% in the BMD at the femoral neck of HIV-positive women taking PI/ART. No difference was registered in the BMD at the lumbar spine between users and non-users of PI/ART. The lack of studies has made it impossible to reach any conclusion regarding the occurrence of fractures.
Carvalho
Erico Higino de
EH
Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil. ericohc@hotmail.com <ericohc@hotmail.com>
Gelenske
Thais
T
Bandeira
Francisco
F
Albuquerque
Maria da Fátima Pessoa Militão de
Mda F
D019380:Anti-HIV Agents / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D002986:Clinical Trials as Topic; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D010024:Osteoporosis / Q000139:chemically induced*
D019380:Anti-HIV Agents