Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetes.
We examined the association between diabetic retinopathy and monocyte chemoattractant protein (MCP)-1 A-2518G polymorphism in 3802 Japanese type 2 diabetic subjects. The prevalence of diabetic retinopathy was higher as the number of G alleles increased, suggesting that the G allele of this polymorphism is a susceptibility allele for diabetic retinopathy.
Katakami
Naoto
N
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. katakami@medone.med.osaka-u.ac.jp
Matsuhisa
Munehide
M
Kaneto
Hideaki
H
Matsuoka
Taka-aki
TA
Imamura
Kenichi
K
Ishibashi
Fukashi
F
Kanda
Tsutomu
T
Kawai
Koichi
K
Osonoi
Takeshi
T
Kashiwagi
Atsunori
A
Kawamori
Ryuzo
R
Shimomura
Iichiro
I
Yamasaki
Yoshimitsu
Y
D000368:Aged; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D018932:Chemokine CCL2 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D022242:Pneumococcal Vaccines; D011110:Polymorphism, Genetic; D012307:Risk Factors
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines