Sodium-independent glutamic acid binding in cultured fibroblasts from patients with Huntington's disease.
Glutamic acid, in the absence of sodium, binds to a single population of binding sites in the fibroblast membrane with a dissociation constant (K(d)) in the nanomolar range, similar to those obtained in human and rat cortices. The density of binding sites (B(max)) in fibroblast membranes from patients with Huntington's disease was only 54% of that in control membranes.
Wong
P T
PT
Kinsmen Laboratory for Neurological Research, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, B.C., Canada V6T 1W5.
Singh
V K
VK
McGeer
E G
EG