title: Review for disease of the year: immunopathogenesis of ocular sarcoidosis.
abstract: Ocular sarcoidosis is a heterogeneous disease having varied presentations and severities with genetic susceptibility playing a role. Sarcoidosis is characterized by the presence of noncaseating (non-necrotizing) granulomas in the affected organs or tissue systems. What causes these granulomas is not known, but current knowledge of the immunology of this enigmatic disease centers on a CD4 T helper type 1 cell response. This review deals with immunologic sequences that lead to the formation of sarcoid granulomas and explores the immunopathogenesis of ocular inflammation seen in patients with sarcoidosis.
authors.affiliation: Doheny Eye Institute, California, USA.
authors.forename: Anita S Y
authors.initials: AS
authors.lastname: Chan
authors.forename: Om P
authors.initials: OP
authors.lastname: Sharma
authors.forename: Narsing A
authors.initials: NA
authors.lastname: Rao
mesh_terms: D016207:Cytokines / Q000276:immunology; D005128:Eye Diseases / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D012507:Sarcoidosis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines