title: Clusterin expression is associated with decreased disease-free survival of patients with colorectal carcinomas.
abstract: OBJECTIVE
  It has been demonstrated that increased clusterin expression is involved in malignant progression and that anticlusterin treatment leads to selective apoptosis. The aim of this study was to determine the clinicopathological significance of clusterin expression in human colorectal carcinomas.
  
  
  RESULTS
  The expression of clusterin was examined in 31 adenomas and 103 colorectal carcinomas. Normal epithelial cells were always negative for clusterin expression, but clusterin expression was present in 16% (5/31) of adenomas and this percentage increased in colorectal carcinomas (30%, 31/103). Immunopositivity always presented an apical cytoplasmic pattern. The expression level of clusterin did not correlate with age, gender, grade or stage. However, its expression was significantly associated with a decrease in disease-free survival (P < 0.05). In a multivariate Cox proportional hazards model, clusterin expression remained a significant independent predictor.
  
  
  CONCLUSIONS
  Clusterin expression may have a role in colonic carcinogenesis and may help identify patients with more aggressive tumours who may benefit from targeted therapy.
authors.affiliation: Department of Biochemistry, Hospital Costa del Sol, CIBER Epidemiología y Salud Pública, Universidad de Málaga, Málaga, Spain. mredondo@hcs.es
authors.forename: Maximino
authors.initials: M
authors.lastname: Redondo
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodrigo
authors.forename: Julia
authors.initials: J
authors.lastname: Alcaide
authors.forename: Teresa
authors.initials: T
authors.lastname: Tellez
authors.forename: María J
authors.initials: MJ
authors.lastname: Roldan
authors.forename: Rafael
authors.initials: R
authors.lastname: Funez
authors.forename: Aurelio
authors.initials: A
authors.lastname: Diaz-Martin
authors.forename: Antonio
authors.initials: A
authors.lastname: Rueda
authors.forename: Eugenio
authors.initials: E
authors.lastname: Jiménez
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D051152:Clusterin / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D051152:Clusterin