Further evidence supporting the association between 5HTR2C gene and bipolar disorder.
Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).
Mazza
Marianna
M
Department of Psychiatry, Catholic University, Gemelli Hospital, Rome, Italy.
Mandelli
Laura
L
Martinotti
Giovanni
G
Di Nicola
Marco
M
Tavian
Daniela
D
Negri
Gloria
G
Colombo
Elisa
E
Missaglia
Sara
S
De Ronchi
Diana
D
Colombo
Roberto
R
Janiri
Luigi
L
Serretti
Alessandro
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult
D044405:Receptor, Serotonin, 5-HT2C