title: Detection of occult melanoma by preoperative positron emission tomography-computed tomography and intraoperative ultrasonography.
abstract: BACKGROUND
  18F-Fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) has become a common imaging modality for detecting metastatic melanoma. However, the identification of lesions intraoperatively can be difficult.
  
  
  OBJECTIVE
  We describe an innovative multimodality approach to tumor localization using preoperative PET-CT and intraoperative ultrasonography and describe cases in which this technique was used.
  
  
  RESULTS
  The use of these two modalities together enabled resection of multiple occult metastatic lesions in the patients presented.
  
  
  CONCLUSIONS
  The use of this multimodality approach will be important in ensuring that all known metastatic disease sites are resected and represents an important concept in the setting of metastatic melanoma resection.
authors.affiliation: Department of Dermatology, University of California-San Francisco, CA 94143-1674, USA.
authors.forename: Brenda A
authors.initials: BA
authors.lastname: Shoo
authors.forename: Gerald
authors.initials: G
authors.lastname: Kangelaris
authors.forename: Peter W
authors.initials: PW
authors.lastname: Callen
authors.forename: Mohammed
authors.initials: M
authors.lastname: Kashani-Sabet
authors.forename: Stanley P L
authors.initials: SP
authors.lastname: Leong
mesh_terms: D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis; D049268:Positron-Emission Tomography; D057234:Preoperative Period; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography