title: Carbon and diamond paste microelectrodes based on Mn(III) porphyrins for the determination of dopamine.
abstract: Three Mn(III) porphyrins were used for the design of carbon paste and diamond paste based microelectrodes, which were employed for the determination of dopamine in pharmaceutical and biological samples using differential pulse voltammetry (DPV). The limits of detection lie between 1.6 x 10(-13) and 2.0 x 10(-6) mol L(-1) while the sensitivities were between 230 pA micromol L(-1) and 3.24 microA mol L(-1). Dopamine was recovered reliable from pharmaceutical and biological samples in percentages higher than 91.00% and 92.00%, respectively. The surface of the microelectrodes can easily be renewed by simple polishing, obtaining a fresh surface ready for use in a new assay.
authors.affiliation: Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest, Romania.
authors.forename: Simona Cornelia
authors.initials: SC
authors.lastname: Balasoiu
authors.forename: Raluca-Ioana
authors.initials: RI
authors.lastname: Stefan-van Staden
authors.forename: Jacobus Frederick
authors.initials: JF
authors.lastname: van Staden
authors.forename: Stela
authors.initials: S
authors.lastname: Pruneanu
authors.forename: Gabriel-Lucian
authors.initials: GL
authors.lastname: Radu
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry; D018130:Diamond / Q000737:chemistry; D004298:Dopamine / Q000032:analysis / Q000652:urine; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D008345:Manganese / Q000737:chemistry; D018625:Microscopy, Atomic Force; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D004364:Pharmaceutical Preparations; D011166:Porphyrins; D008345:Manganese; D002244:Carbon; D018130:Diamond; D004298:Dopamine