title: 5-HT metabolism in the intestinal wall of the rat-I. The mucosa.
abstract: Serotonin (5-HT) metabolism was studied on isolated mucosa of the rat caecum in order to determine its characteristics in enterochromaffin cells. High levels of 5-HT were found in these cells and weak catabolic processes were demonstrated. Enterochromaffin cells of the mucosa are able to synthesize ((3)H)5-HT from ((3)H)tryptophan in vitro indicating that these cells might contain tryptophan hydroxylase. In addition, a high affinity uptake of exogenous ((3)H)5-HT is demonstrated. These results show that enterochromaffin cells of the mucosa present similar biochemical properties compared to those described for serotoninergic neurons of the central nervous system.
authors.affiliation: INSERM-U.6 and CNRS-GR.45, 280 Bd Sainte-Marguerite, 13009 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Legay
authors.forename: M
authors.initials: M
authors.lastname: Faudon
authors.forename: F
authors.initials: F
authors.lastname: Héry
authors.forename: J P
authors.initials: JP
authors.lastname: Ternaux