title: On-line monitoring of a microwave-assisted chemical reaction by nanolitre NMR-spectroscopy.
abstract: We report the use of a nanolitre nuclear magnetic resonance (NMR) spectroscopy microfluidic chip hyphenated to a continuous-flow microlitre-microwave irradiation set-up, for on-line monitoring and rapid optimization of reaction conditions.
authors.affiliation: Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Gomez
authors.forename: Hein H J
authors.initials: HH
authors.lastname: Verputten
authors.forename: Angel
authors.initials: A
authors.lastname: Díaz-Ortíz
authors.forename: Andres
authors.initials: A
authors.lastname: Moreno
authors.forename: Antonio
authors.initials: A
authors.lastname: de la Hoz
authors.forename: Aldrik H
authors.initials: AH
authors.lastname: Velders
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008872:Microwaves; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009930:Organic Chemicals