DNA damage and impairment of DNA repair in Alzheimer's disease.
Deoxyribonucleic acid (DNA) damage has been implicated in ageing and neurodegenerative disorders including Alzheimer's disease (AD) for a few decades. Although it is an established finding, yet there are limited studies on DNA damage. In both nucleus and mitochondria, DNA damage is primarily free radical mediated. It has been proven that mitochondrial DNA is more vulnerable to damage compared to the nuclear DNA. A few studies summarized in this review throw light on the mechanisms of free radical mediated DNA damage and impairment of DNA repair mechanisms in AD. There is a growing need to initiate studies on DNA damage and repair and unravel the molecular underpinnings entailed in the etiopathogenesis of the disease. The outcome of such studies substantiates the corner stone streamlined to employ therapeutic strategies.
Obulesu
M
M
Department of Biotechnology, Srikrishnadevaraya University, Anantapur, Andhra Pradesh, India.
Rao
Dowlathabad Muralidhara
DM
D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D004249:DNA Damage / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D004272:DNA, Mitochondrial; D006801:Humans
D004272:DNA, Mitochondrial