Cyclodextrins: more than pharmaceutical excipients.
Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs. Recent findings have shown them to display adjuvant activity in vaccine therapy and prophylactic and therapeutic activity in the treatment of several host-pathogen infections. This article focuses on their activity and mechanism of action.
Otero-Espinar
F J
FJ
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Campus Universitario sur s/n. 15782 Santiago de Compostela, Spain. francisco.otero@usc.es
Luzardo-Alvarez
A
A
Blanco-Méndez
J
J
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D003505:Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology; D005079:Excipients / Q000737:chemistry* / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology; D017510:Protein Folding
D000900:Anti-Bacterial Agents; D000977:Antiparasitic Agents; D000998:Antiviral Agents; D003505:Cyclodextrins; D005079:Excipients; D007155:Immunologic Factors