title: [Chronic occupational bronchitis in workers of coal extracting enterprises in Kouzbass: role of endogenous factors].
abstract: The authors studied distribution of biochemical markers for HP, GC, EsD, AcP genes, polymorphism of GSTT1 (GST-theta 1), GSTM1 (GST-mu 1), locus WNTR of NOS3 gene (alleles A/B) in chronic dust bronchitis patients and in apparently healthy individuals. Genotypes EsD 1-2 and AcP bb individuals were proved to be most prone to the disease. Endogenous resistent factors for chronic dust bronchitis are genotypes GC 1-1, EsD 1-1, AcP bc.
authors.forename: N I
authors.initials: NI
authors.lastname: Gafarov
authors.forename: V V
authors.initials: VV
authors.lastname: Zakharenkov
authors.forename: N I
authors.initials: NI
authors.lastname: Panev
authors.forename: A V
authors.initials: AV
authors.lastname: Burdeĭn
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: A A
authors.initials: AA
authors.lastname: Rudko
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D029481:Bronchitis, Chronic / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D043182:Carboxylesterase / Q000097:blood; D003031:Coal; D003032:Coal Mining; D004391:Dust; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D015995:Prevalence; D012800:Siberia / Q000453:epidemiology; D014809:Vitamin D-Binding Protein / Q000097:blood
chemical_list: D015415:Biomarkers; D003031:Coal; D004391:Dust; D006242:Haptoglobins; D014809:Vitamin D-Binding Protein; D043182:Carboxylesterase; C020118:ESD protein, human; D000135:Acid Phosphatase