Aptamer-based carbohydrate recognition.
Carbohydrates have been revealed to play fundamental roles in diverse biological phenomena, such as being recognition sites and biomarkers. Recently, ample nucleic acid aptamers guided for carbohydrate recognition have already been isolated and characterized through SELEX methodology. This review would like to present and discuss these aptamers toward recognizing various carbohydrate targets: monosaccharides, oligosaccharides, polysaccharides, aminoglycoside antibiotics and glycans from glycoproteins. High affinity carbohydrate aptamers that we reviewed herein might shed light on the development of a tool to augment drug discovery creations.
Sun
Wei
W
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong, 250012, China.
Du
Lupei
L
Li
Minyong
M
D052157:Aptamers, Nucleotide; D002241:Carbohydrates / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000145:classification; D054794:Glycomics / Q000379:methods*; D006801:Humans; D008024:Ligands; D052156:SELEX Aptamer Technique / Q000379:methods*
D052157:Aptamers, Nucleotide; D002241:Carbohydrates; D008024:Ligands