title: Polymyxin-direct hemoperfusion for sepsis-induced multiple organ failure.
abstract: We report a case of multiple organ failure caused by the Bacillus cereus infection during acute lymphoblastic leukemia therapy, who was treated successfully. A 15-year-old male developed (B. cereus) sepsis on the 19th day after chemotherapy initiation. Polymyxin-direct hemoperfusion for septic shock was started, followed by continuous hemodiafiltration. His condition improved after starting the hemoperfusion. At the onset of sepsis, elevated levels of serum inflammatory cytokines, anti-inflammatory cytokines, and plasminogen-activator inhibitor complex-1 were observed. Serum levels of these cytokines and bioactive substances decreased after blood purification therapy, which correlated with the improvement of clinical symptoms.
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. k-hira@naganoch.gr.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shiohara
authors.forename: Shoji
authors.initials: S
authors.lastname: Saito
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Ryu
authors.initials: R
authors.lastname: Yanagisawa
authors.forename: Goro
authors.initials: G
authors.lastname: Tsuruta
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hidaka
authors.forename: Yozo
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakashita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Koike
mesh_terms: D000293:Adolescent; D001409:Bacillus cereus / Q000302:isolation & purification; D016207:Cytokines / Q000097:blood; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology* / Q000628:therapy*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011113:Polymyxins / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D018805:Sepsis / Q000150:complications* / Q000628:therapy*
chemical_list: D016207:Cytokines; D017395:Plasminogen Activator Inhibitor 1; D011113:Polymyxins