title: Protein kinase C in the nervous system of insects: effects of phorbol esters on cholinergic synapses.
abstract: Specific high affinity binding sites for phorbol esters have been demonstrated in the nervous tissue of locust. The binding was reduced by the kinase C-inhibitor polymyxin B. Phorbol esters in micromolar concentrations activated protein kinase C in subcellular preparations from locust ganglia. The same concentrations of phorbol esters significantly enhanced the high affinity transport of choline and the release of acetylcholine by locust synaptosomes.
authors.affiliation: Dept. Zoophysiology, University of Osnabrück, 4500 Osnabrück, F.R.G.
authors.forename: M
authors.initials: M
authors.lastname: Knipper
authors.forename: H
authors.initials: H
authors.lastname: Breer