title: Pilot study on the efficacy of paromomycin as a histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
abstract: Paromomycin is an aminoglycoside antibiotic with activity against protozoa. Currently, paromomycin is registered for food producing animal species. In a pilot study we evaluated the efficacy of different doses of paromomycin in the feed against Histomonas meleagridis in experimentally challenged turkey poults. Groups consisting of 30 birds each were given feed with 100, 200 and 400 ppm paromomycin, respectively, starting on day 1 through to day 42. One group of 30 birds was left untreated. On day 21 all birds were infected intracloacally with H. meleagridis. Additionally, 10 birds were kept as a non-infected and non-treated control group. Before the challenge there was no significant difference between untreated and treated groups with regards to feed consumption and feed conversion rate. After the challenge, mortality was 80% in the infected nontreated birds. In the treated groups the mortality rate was 73.3%, 43.3% and 20%, respectively. No histomonal DNA was found in caeca and livers of the surviving birds. In addition, higher doses of paromomycin (200 and 400 ppm) led to reduced counts of Clostridium perfringens in the droppings. In conclusion, a prophylactic application of paromomycin as a feed additive was effective against the challenge with H. meleagridis under experimental conditions.
authors.affiliation: Institute of Poultry Diseases, Faculty of Veterinary Medicine, Free University Berlin, Germany. hafez@vetmed.fu-berlin.de
authors.forename: Hafez M
authors.initials: HM
authors.lastname: Hafez
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Hauck
authors.forename: Wael
authors.initials: W
authors.lastname: Gad
authors.forename: Koen
authors.initials: K
authors.lastname: De Gussem
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Lotfi
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001835:Body Weight; D002432:Cecum / Q000473:pathology; D003016:Clostridium perfringens / Q000302:isolation & purification; D004032:Diet / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005243:Feces / Q000382:microbiology; D008099:Liver / Q000473:pathology; D008297:Male; D010303:Paromomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D010865:Pilot Projects; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D011528:Protozoan Infections / Q000188:drug therapy*; D014422:Turkeys
chemical_list: D000981:Antiprotozoal Agents; D010303:Paromomycin