MicroRNA as a new player in the cell cycle.
MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein-coding genes and specific pathways during the cell cycle. This review focuses on the functions of miRNAs in the cell cycle of differentiated cells and embryonic stem (ES) cells. Aberrant expression of these cell-cycle-related miRNAs may result in carcinogenesis, revealing the potential of miRNAs as therapeutic targets for clinical purposes.
Chen
Dongliang
D
Department of Biology, East Carolina University, Greenville, North Carolina 27858, USA.
Farwell
Mary A
MA
Zhang
Baohong
B
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D005810:Multigene Family; D015398:Signal Transduction
D035683:MicroRNAs