title: Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures.
abstract: Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA. percec@sas.upenn.edu
authors.forename: Virgil
authors.initials: V
authors.lastname: Percec
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Wilson
authors.forename: Pawaret
authors.initials: P
authors.lastname: Leowanawat
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Wilson
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hughes
authors.forename: Mark S
authors.initials: MS
authors.lastname: Kaucher
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Hammer
authors.forename: Dalia H
authors.initials: DH
authors.lastname: Levine
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Kim
authors.forename: Frank S
authors.initials: FS
authors.lastname: Bates
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Davis
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Lodge
authors.forename: Michael L
authors.initials: ML
authors.lastname: Klein
authors.forename: Russell H
authors.initials: RH
authors.lastname: DeVane
authors.forename: Emad
authors.initials: E
authors.lastname: Aqad
authors.forename: Brad M
authors.initials: BM
authors.lastname: Rosen
authors.forename: Andreea O
authors.initials: AO
authors.lastname: Argintaru
authors.forename: Monika J
authors.initials: MJ
authors.lastname: Sienkowska
authors.forename: Kari
authors.initials: K
authors.lastname: Rissanen
authors.forename: Sami
authors.initials: S
authors.lastname: Nummelin
authors.forename: Jarmo
authors.initials: J
authors.lastname: Ropponen
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D040761:Biomimetic Materials / Q000737:chemistry; D020285:Cryoelectron Microscopy; D050091:Dendrimers / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers; D057927:Hydrophobic and Hydrophilic Interactions; D008567:Membranes, Artificial; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D049329:Nanostructures; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water
chemical_list: D000903:Antibiotics, Antineoplastic; D050091:Dendrimers; D004337:Drug Carriers; D008567:Membranes, Artificial; D013501:Surface-Active Agents; D014867:Water; D004317:Doxorubicin