title: Iodine-promoted domino reaction leading to N-substituted 2-aminoquinoline-3-carbonitriles under microwave irradiation.
abstract: A new iodine-promoted domino reaction of 2-aminochromene-3-carbonitriles with various isocyanates is described, and a set of polyfunctionalized N-substituted 2-aminoquinoline-3-carbonitriles with high regioselectivity were successfully synthesized under microwave heating. In this reaction, the ring-opening/recyclization process occurs unexpectedly at the ring of 4H-pyran with different isocyanates.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
mesh_terms: D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D009570:Nitriles; D011804:Quinolines; D007455:Iodine