title: Model-Based Background Correction (MBCB): R Methods and GUI for Illumina Bead-array Data.
abstract: SUMMARY: Illumina BeadArray platform (Illumina Inc.) is playing an increasing role in cancer research. MBCB, an R package designed for use on Illumina Bead-Array data, allows for microarray data to be pre-processed through various model-based statistical methods. These model-based background-correction methods have proven to be a significant improvement over the traditional methods provided by Illumina in their BeadStudio software. MBCB accepts the summarized bead-type data; the data can then be normalized and background-corrected in a statistically-efficient manner. When compared to the popular Robust multi-array (RMA) background correction approach and the default, Illumina-provided background-correction method, MBCB has shown to lead to more precise determination of gene expression and better biological interpretation of Illumina BeadArray data. The software developed will facilitate molecular biomedical - especially cancer - research. AVAILABILITY: This package will soon be available from Bioconductor. Instructions for use are included with the package.
authors.affiliation: Department of Computer Science and Engineering, Southern Methodist University, Dallas, TX, 75205, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Allen
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie