title: [Optic neuritis, multiple sclerosis-related or not: structural and functional study].
abstract: BACKGROUND
  Multiple sclerosis (MS) is an inflammatory demyelinating disease with axonal degeneration. Optical coherence tomography (OCT) is a noninvasive technique that quantifies the thickness of the retinal nerve fiber layer (RNFL). The objectives of this study are: to determine the thickness of the RNFL in MS patients with or without previous optic neuritis (ON) and in patients with ON and to determine the relationship between the structural damage and functional alterations in visual acuity (VA) and visual field (VF).
  
  
  METHODS
  Three groups were studied: G1 - patients with ON, G2 - patients with MS and ON, and G3 - patients with MS and without previous ON. Ophthalmological (VA, VF, OCT) and neurological examinations were performed.
  
  
  RESULTS
  OCT thickness in the unaffected eye was significantly thicker in ON patients (103.99) than in the other groups, however there was no differences among the affected eyes. There were significant differences in VA and VF among the non-affected eyes (p = 0.007), but not among the affected eyes (p = 0.878).
  
  
  CONCLUSIONS
  All MS patients showed axonal damage in both optic nerves, more in patients with previous ON. Axonal damage was detected early, so OCT could be used as a structural biomarker. Structural damage was related with the functional alterations.
authors.affiliation: Servicio de Neurología, Unidad de Neuroinmunología Clínica y Esclerosis Múltiple, Hospital Universitario La Paz, Madrid, España. orejacbn@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Oreja-Guevara
authors.forename: S
authors.initials: S
authors.lastname: Noval
authors.forename: B
authors.initials: B
authors.lastname: Manzano
authors.forename: E
authors.initials: E
authors.lastname: Diez-Tejedor
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D009900:Optic Nerve / Q000033:anatomy & histology / Q000473:pathology; D009902:Optic Neuritis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields; D055815:Young Adult