title: [Antiemetic-induced extrapyramidal symptoms seen by our palliative care team].
abstract: BACKGROUND
  Antiemetic drugs, which are usually prescribed with opioids, occasionally induce extrapyramidal symptoms(EPS).
  
  
  METHODS
  In 109 patients treated with our palliative care team, we retrospectively investigated the appearance of antiemetic-induced EPS; its incidence, latent period, onset age, symptoms, causing agents and clinical outcomes.
  
  
  RESULTS
  EPS were observed in 6 of 109 patients. Six EPS patients, 2 men and 4 women, were between the age of 53 and 66 years. Prochlorperazine was used in all EPS patients. Two EPS were induced with unnecessary antiemetic drugs. Onset of EPS was from 11 to 162 days after beginning of antiemetic drugs. There were 5 patients with slow movement or speech, 3 patients with expressionless face, 2 patients with akathisia, and one patient with dysphagia. Five EPS patients were improved by using biperiden and one patient was by changing prochlorperazine to perospirone.
  
  
  CONCLUSIONS
  EPS were found in 6 of 109 patients during palliative care. We concluded that it was important not to forget the appearance of antiemetic-induced EPS when prescribing antiemetic drugs in palliative
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nakanuno
authors.forename: Taishin
authors.initials: T
authors.lastname: Ito
authors.forename: Aki
authors.initials: A
authors.lastname: Matsunaga
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D000932:Antiemetics / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010348:Patient Care Team; D011346:Prochlorperazine / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000701:Analgesics, Opioid; D000932:Antiemetics; D011346:Prochlorperazine