Plasma apelin and ADMA Levels in patients with essential hypertension.
Both apelin and asymetric dymethyl arginine (ADMA) regulate blood pressures. Low apelin and high ADMA levels have been reported in several cardiometabolic disorders. However, there is no data about ADMA and apelin levels in essential hypertension and any relationship between them. We investigated a group of newly diagnosed and untreated 30 young hypertensive men and 30 healthy controls. Apelin levels were significantly lower and the ADMA levels were significantly higher in the patients (p = 0.04 for both). Both ADMA and apelin were related to the systolic blood pressures (SBP) (beta = -0.393, p = 0.003; beta = 0.285, p = 0.03, respectively). Future studies are necessary in order to clearly define the role of ADMA and apelin in the pathogenesis of essential hypertension.
Sonmez
Alper
A
Department of Endocrinology, Gulhane School of Medicine, 06018 Etlik Ankara, Turkey. alpersonmez@yahoo.com
Celebi
Gurkan
G
Erdem
Gokhan
G
Tapan
Serkan
S
Genc
Halil
H
Tasci
Ilker
I
Ercin
Cemal Nuri
CN
Dogru
Teoman
T
Kilic
Selim
S
Uckaya
Gokhan
G
Yilmaz
Mahmut Ilker
MI
Erbil
Mehmet Kemal
MK
Kutlu
Mustafa
M
D000328:Adult; D000073861:Apelin; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology; D004791:Enzyme Inhibitors; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000378:metabolism; D008297:Male; D018709:Statistics, Nonparametric; D055815:Young Adult
C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D004791:Enzyme Inhibitors; D036341:Intercellular Signaling Peptides and Proteins; C018524:N,N-dimethylarginine; D001120:Arginine