title: Biological effects of high molecular weight lignin derivatives.
abstract: A number of high molecular weight (HMW) lignin derivatives possessing varied chemical properties were screened for their biological effects in order to obtain more information on the possible structural features of HMW lignin-related effects. The studied compounds were both commercial and in-house extracted lignin derivatives. Bioassays used include reverse electron transport (RET), Vibrio fischeri, Daphnia magna, and juvenile rainbow trout (Oncorhynchus mykiss) hepatocytes. The studied lignin derivatives inhibited the in vitro systems and luminescence of V. fischeri bacteria to some extent-daphnids were not affected. It seems that, at least in the RET assay, certain pH-dependent functional groups in lignin may be of importance regarding the biological effects.
authors.affiliation: Finnish Environment Institute, Hakuninmaantie 6, FI-00430 Helsinki, Finland. Piia.pessala@gaia.fi
authors.forename: Piia
authors.initials: P
authors.lastname: Pessala
authors.forename: Eija
authors.initials: E
authors.lastname: Schultz
authors.forename: Jukka
authors.initials: J
authors.lastname: Kukkola
authors.forename: Tarja
authors.initials: T
authors.lastname: Nakari
authors.forename: Juha
authors.initials: J
authors.lastname: Knuutinen
authors.forename: Sirpa
authors.initials: S
authors.lastname: Herve
authors.forename: Jaakko
authors.initials: J
authors.lastname: Paasivirta
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D003621:Daphnia / Q000187:drug effects; D004579:Electron Transport / Q000187:drug effects; D005387:Finland; D022781:Hepatocytes / Q000187:drug effects; D008031:Lignin / Q000737:chemistry* / Q000633:toxicity*; D017686:Oncorhynchus mykiss / Q000378:metabolism; D010209:Paper; D018675:Toxicity Tests; D014733:Vibrio / Q000187:drug effects; D014865:Waste Disposal, Fluid / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D008031:Lignin; D019363:Cytochrome P-450 CYP1A1