Enzymatic synthesis of poly-L-lactide-co-glycolide in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate.
This article reports the lipase-catalyzed ring-opening copolymerization of L-lactide (LLA) and glycolide using the commercially available ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate as solvent media. Candida antarctica lipase B, immobilized in an acrylic support was used as biocatalyst. The reaction temperature had a direct influence on yields and molecular weights of the copolymers as well as LLA incorporation. The materials presented semi-crystalline structures assessed by DSC and powder XR diffraction analyses.
Mena
María
M
Depto. Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de Mexico, Ciudad Universitaria, Mexico D.F., Mexico.
Chanfreau
Sébastien
S
Gimeno
Miquel
M
Bárzana
Eduardo
E
D001709:Biotechnology / Q000379:methods*; D002175:Candida / Q000201:enzymology*; D002384:Catalysis; D005656:Fungal Proteins; D007093:Imidazoles / Q000737:chemistry*; D007218:Industrial Microbiology / Q000379:methods; D007477:Ions; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D011098:Polyglactin 910 / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
C412621:1-butyl-3-methylimidazolium hexafluorophosphate; D005656:Fungal Proteins; D007093:Imidazoles; D007477:Ions; D011108:Polymers; D011208:Powders; D011098:Polyglactin 910; D008049:Lipase; C431349:lipase B, Candida antarctica