title: Design, synthesis and antibacterial activity of novel andrographolide derivatives.
abstract: A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds.
authors.affiliation: Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China.
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Wang
authors.forename: Pei
authors.initials: P
authors.lastname: Yu
authors.forename: Gaoxiao
authors.initials: G
authors.lastname: Zhang
authors.forename: Lipeng
authors.initials: L
authors.lastname: Xu
authors.forename: Dingyuan
authors.initials: D
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Xiangping
authors.initials: X
authors.lastname: Zeng
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D011710:Pyocyanine / Q000037:antagonists & inhibitors / Q000378:metabolism; D053038:Quorum Sensing / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: C552761:14-(5-cyclopentylvaleryl)andrographolide; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D004224:Diterpenes; C030419:andrographolide; D011710:Pyocyanine