Montelukast therapy and psychological distress in chronic obstructive pulmonary disease (COPD): a preliminary report.
Chronic obstructive pulmonary disease (COPD) is an alteration in which ventilatory function, exercise capacity and health status of patients progressively decline and it is characterized by an increase of inflammatory cytokines such as TNF-α, LTB4, IL-8, etc. In this study we considered twenty patients (15 males and 5 females; mean age: 72.8 ± 6.3) with stable COPD. All patients were performed evaluation of psychological stress at enrollment and were treated with leukotriene receptor antagonists (montelukast tablets) 10mg/day for 12 months. After 12 months we observed a significant decrease of serum levels of LTB4, IL-8 and also a decrease of the number of outpatient clinic visits, of the number of hospitalizations and of the duration of hospitalization.
Gueli
Nicolò
N
Department of Aging Science, Policlinico Umberto I, Sapienza University of Rome, viale del Policlinico, 155, I-00161 Roma, Italy. nicolo.gueli@uniroma1.it
Verrusio
Walter
W
Linguanti
Adele
A
De Santis
Wladimiro
W
Canitano
Nicoletta
N
Ippoliti
Flora
F
Marigliano
Vincenzo
V
Cacciafesta
Mauro
M
D000085:Acetates / Q000627:therapeutic use*; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D003521:Cyclopropanes; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D007975:Leukotriene B4 / Q000097:blood; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000188:drug therapy / Q000523:psychology*; D011804:Quinolines / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000209:etiology*; D013440:Sulfides; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D016209:Interleukin-8; D011804:Quinolines; D013440:Sulfides; D014409:Tumor Necrosis Factor-alpha; D007975:Leukotriene B4; C093875:montelukast