title: Plasma apelin and ADMA Levels in patients with essential hypertension.
abstract: Both apelin and asymetric dymethyl arginine (ADMA) regulate blood pressures. Low apelin and high ADMA levels have been reported in several cardiometabolic disorders. However, there is no data about ADMA and apelin levels in essential hypertension and any relationship between them. We investigated a group of newly diagnosed and untreated 30 young hypertensive men and 30 healthy controls. Apelin levels were significantly lower and the ADMA levels were significantly higher in the patients (p = 0.04 for both). Both ADMA and apelin were related to the systolic blood pressures (SBP) (beta = -0.393, p = 0.003; beta = 0.285, p = 0.03, respectively). Future studies are necessary in order to clearly define the role of ADMA and apelin in the pathogenesis of essential hypertension.
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, 06018 Etlik Ankara, Turkey. alpersonmez@yahoo.com
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
authors.forename: Gurkan
authors.initials: G
authors.lastname: Celebi
authors.forename: Gokhan
authors.initials: G
authors.lastname: Erdem
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Halil
authors.initials: H
authors.lastname: Genc
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Cemal Nuri
authors.initials: CN
authors.lastname: Ercin
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Selim
authors.initials: S
authors.lastname: Kilic
authors.forename: Gokhan
authors.initials: G
authors.lastname: Uckaya
authors.forename: Mahmut Ilker
authors.initials: MI
authors.lastname: Yilmaz
authors.forename: Mehmet Kemal
authors.initials: MK
authors.lastname: Erbil
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kutlu
mesh_terms: D000328:Adult; D000073861:Apelin; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology; D004791:Enzyme Inhibitors; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000378:metabolism; D008297:Male; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D004791:Enzyme Inhibitors; D036341:Intercellular Signaling Peptides and Proteins; C018524:N,N-dimethylarginine; D001120:Arginine