ABO hemolytic disease of the fetus and newborn: an iatrogenic complication of heterologous assisted reproductive technology-induced pregnancy.
BACKGROUND
ABO hemolytic disease of the fetus and newborn (ABO HDFN) may manifest itself in cases of mothers belonging to blood group O and newborns of groups A or B and more frequently in group A and less so in group B.


METHODS
The case subjects are twin-birth newborns with ABO HDFN, of group AB born to a mother of group O. These cases of ABO HDFN prove inconsistent with Mendel's law of segregation.


CONCLUSIONS
This case study finds its explanation in new methods of assisted reproduction, particularly heterologous in vitro fertilization with ovodonation.
Zuppa
Antonio Alberto
AA
Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy. zuppaaa@rm.unicatt.it
Cardiello
Valentina
V
Lai
Marco
M
Cataldi
Luigi
L
D'Andrea
Vito
V
Romagnoli
Costantino
C
D000017:ABO Blood-Group System / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*
D000017:ABO Blood-Group System; D001663:Bilirubin