Administration of steroids after 34 weeks of gestation enhances fetal lung maturity profiles.
OBJECTIVE
To estimate the effect of antenatal glucocorticoid administration on fetal lung maturity in pregnancies with known fetal lung immaturity between the 34th and 37th weeks of gestation.


METHODS
Pregnancies between 34(0/7) and 36(6/7) weeks undergoing amniocentesis to determine fetal lung maturity were targeted. Women with negative results (TDx-FLM-II <45 mg/g) were randomly assigned to intramuscular glucocorticoid injection or no treatment. A repeat TDx-FLM-II test was obtained 1 week after enrollment.


RESULTS
Thirty-two women who met inclusion criteria were randomly assigned. Seven women delivered within a week of testing for fetal lung maturity, and were excluded from the analysis. Ten received glucocorticoid and 15 did not. Women assigned to glucocorticoids had a mean increase TDx-FLM-II in 1 week of 28.37 mg/g. Women assigned to no-treatment had an increase of 9.76 mg/g (P < .002).


CONCLUSIONS
A single course of intramuscular glucocorticoids after 34 weeks in pregnancies with documented fetal lung immaturity significantly increases TDx- FLM-II.
Shanks
Anthony
A
Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA.
Gross
Gilad
G
Shim
Tammy
T
Allsworth
Jenifer
J
Sadovsky
Yoel
Y
Bildirici
Ibrahim
I
D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects* / Q000196:embryology*; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control
D005938:Glucocorticoids; D003907:Dexamethasone