Iridium-catalyzed enantioselective allylic substitution of o-allyl carbamothioates.
With an [Ir(COD)Cl](2)/phosphoramidite ligand system, an allylic substitution of O-allyl carbamothioates was developed. The reaction proceeded in the favor of branched products with up to 93:7 branched-to-linear ratio, affording chiral S-allyl carbamothioates with up to 95% ee.
Xu
Qing-Long
QL
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Liu
Wen-Bo
WB
Dai
Li-Xin
LX
You
Shu-Li
SL