title: Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member miR-429.
abstract: The miR-200 microRNA family is important for maintaining the epithelial phenotype, partially through suppressing ZEB1 and ZEB2. Since ZEB1 inhibits Epstein-Barr virus (EBV) reactivation, we hypothesized that expression of miR-200 family members in epithelial cells may partly account for higher levels of EBV reactivation in this tissue (relative to nonplasma B cells). Here we show that, whereas miR-200 family members are expressed in epithelial cells, their expression is low in latently infected B cells. Furthermore, the miR-200 family member miR-429 shows elevated expression in plasma cell lines and is induced by B-cell-receptor activation in Akata cells. Lastly, expression of miR-429 can break latency.
authors.affiliation: Department of Pathology, SL-79, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lin
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Claire
authors.initials: C
authors.lastname: Fewell
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cameron
authors.forename: Qinyan
authors.initials: Q
authors.lastname: Yin
authors.forename: Erik K
authors.initials: EK
authors.lastname: Flemington
mesh_terms: D001402:B-Lymphocytes / Q000821:virology*; D004847:Epithelial Cells / Q000821:virology*; D020869:Gene Expression Profiling; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis*; D014775:Virus Activation
chemical_list: C533896:MIRN200 microRNA, human; C546363:MIRN429 microRNA, human; D035683:MicroRNAs