Modulation of [(3)H]noradrenaline release by endothelin-1 in the rat tail artery.
The effect of endothelin-1 (ET-1) on the increase in perfusion pressure and the release of noradrenaline produced by electrical field stimulation were examined in isolated perfused/superfused rat tail arteries. ET-1 (1-30 nM) increased, in an identical concentration-dependent manner, the basal perfusion pressure and the stimulation-evoked tritum overflow, whereas the basal outflow of noradrenaline was not changed by the peptide. These results show that, besides its postjunctional vasoconstrictor effect, ET-1 exerts in the rat tail artery a prejunctional action which might be involved in the modulation of stimulation-evoked noradrenaline release from postganglionic nerves.
Bucher
B
B
Laboratoire de Pharmacologie Cellulaire et Moléculaire, CNRS URA 600, B.P. 24, 67401 Illkirch Cedex, France.
Paya
D
D
Stoclet
J C
JC