Stereochemical and skeletal diversity arising from amino propargylic alcohols.
An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.
Pizzirani
Daniela
D
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Kaya
Taner
T
Clemons
Paul A
PA
Schreiber
Stuart L
SL
D000605:Amino Alcohols / Q000737:chemistry*; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000605:Amino Alcohols; D006576:Heterocyclic Compounds, 4 or More Rings