The emerging role of adipokines in osteoarthritis: a narrative review.
Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression of OA.
Hu
Peng-fei
PF
Zhejiang University College of Medicine, Hangzhou, People's Republic of China.
Bao
Jia-peng
JP
Wu
Li-dong
LD
D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D020738:Leptin / Q000378:metabolism; D008297:Male; D051379:Mice; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism; D010003:Osteoarthritis / Q000378:metabolism*; D052243:Resistin / Q000378:metabolism; D012307:Risk Factors
D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase