No association between polymorphisms of WNT2 and schizophrenia in a Korean population.
BACKGROUND
Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population.


METHODS
e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls.


RESULTS
Of the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction.


CONCLUSIONS
The present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.
Kim
Hak-Jae
HJ
College of Medicine, Soonchunhyang University, Chunan 336-745, Republic of Korea.
Park
Jin Kyung
JK
Kim
Su Kang
SK
Kang
Sung Wook
SW
Kim
Jong Woo
JW
Park
Hyun-Kyung
HK
Cho
Ah-Rang
AR
Song
Ji Young
JY
Chung
Joo-Ho
JH
D000328:Adult; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D051154:Wnt2 Protein / Q000235:genetics*
C495244:WNT2 protein, human; D051154:Wnt2 Protein