title: Advances in eicosanoid research, novel therapeutic implications.
abstract: Eicosanoids are a family of oxygenated metabolites of arachidonic acid, including the prostaglandins, thromboxanes, leukotrienes and lipoxins. These lipid mediators play essential roles in normal cellular homeostasis as well as in a number of disease states. This review will focus on recent advances in the field of eicosanoids and highlight specific discoveries and achievements. Emphasis will be placed on structure and receptor biology, which are of significant pharmacological and clinical relevance.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Division of Chemistry 2, Karolinska Institutet, S-17177 Stockholm, Sweden. jesper.haeggstrom@ki.se
authors.forename: Jesper Z
authors.initials: JZ
authors.lastname: Haeggström
authors.forename: Agnes
authors.initials: A
authors.lastname: Rinaldo-Matthis
authors.forename: Craig E
authors.initials: CE
authors.lastname: Wheelock
authors.forename: Anders
authors.initials: A
authors.lastname: Wetterholm
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D035843:Biomedical Research; D002352:Carrier Proteins / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism; D015195:Drug Design; D004537:Eicosanoic Acids / Q000378:metabolism*; D054513:Group IV Phospholipases A2 / Q000378:metabolism; D006801:Humans; D020024:Leukotriene Antagonists / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D015289:Leukotrienes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D018077:Receptors, Leukotriene / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D002352:Carrier Proteins; D016861:Cyclooxygenase Inhibitors; D004537:Eicosanoic Acids; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D008565:Membrane Proteins; D018077:Receptors, Leukotriene; D001094:Arachidonate 5-Lipoxygenase; D054513:Group IV Phospholipases A2