Postinfectious immunodeficiency and autoimmunity: pathogenic and clinical values and implications.
Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development.
Khitrov
Alexander N
AN
IM Sechenov Moscow Medical Academy, Department of Pathology, Moscow, Russia. khitrov@wolga.msk.ru
Shogenov
Zaur S
ZS
Tretyak
Eugenia B
EB
Ischenko
Anatoly I
AI
Matsuura
Eiji
E
Neuhaus
Oliver
O
Paltsev
Mikhail A
MA
Suchkov
Sergey V
SV