title: Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts.
abstract: A highly efficient diastereo- and enantioselective Mannich reaction of lactones with a variety of N-Boc-aldimines by using bifunctional rosin-derived amine thiourea catalysts was investigated for the first time, in general, affording the adducts bearing quaternary stereogenic centers with high levels of enantio- and diastereoselectivity (up to 99% ee, and >20:1 dr).
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.forename: Dan
authors.initials: D
authors.lastname: Fu
authors.forename: Gen
authors.initials: G
authors.lastname: Zhang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Cao
authors.forename: Luping
authors.initials: L
authors.lastname: Liu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Song
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007783:Lactones / Q000737:chemistry*; D008352:Mannich Bases / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000588:Amines; D007783:Lactones; D008352:Mannich Bases; D012116:Resins, Plant; C013893:rosin; D013890:Thiourea