Tacrolimus-induced polyneuropathy after heart transplantation.
Tacrolimus has been often described to induce neuropathy in liver-, pancreas-, and renal-transplanted patients. Here, we report the first case of a 56-year-old woman who developed a progressive symmetric demyelinating sensorimotor polyneuropathy in the distal muscles of the lower limbs after therapy with tacrolimus because of heart transplantation. This condition suddenly reverted after the tacrolimus was stopped.
Labate
Angelo
A
Institute of Neurology, University Magna Graecia of Catanzaro, Catanzaro, Italy. a.labate@isn.cnr.it
Morelli
Maurizio
M
Palamara
Grazia
G
Pirritano
Domenico
D
Quattrone
Aldo
A
D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D018450:Disease Progression; D016903:Drug Monitoring; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D035002:Lower Extremity; D008875:Middle Aged; D011115:Polyneuropathies / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016559:Tacrolimus