Syntheses and antibacterial properties of iso-platencin, Cl-iso-platencin and Cl-platencin: identification of a new lead structure.
Platencin is a novel antibiotic which is active against multiresistant pathogens. We describe efficient syntheses of three platencin analogues of varying activities which allow further conclusions about the pharmacophoric part of the molecule. The unnatural antibiotic iso-platencin, which is about as active as natural platencin, but much more selective, was identified as a new lead structure.
Tiefenbacher
Konrad
K
University of Vienna, Institute of Organic Chemistry, Währingerstrasse 38, 1090 Wien, Austria.
Gollner
Andreas
A
Mulzer
Johann
J
D000627:Aminophenols / Q000138:chemical synthesis* / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002712:Chlorides / Q000138:chemical synthesis* / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000627:Aminophenols; D000900:Anti-Bacterial Agents; D002712:Chlorides; D011083:Polycyclic Compounds; C520340:platencin