title: Characteristics of lipo-oligosaccharide loci of Campylobacter jejuni isolates associated with Guillain-Barré Syndrome from Hebei, China.
abstract: Ganglioside mimicry by C.jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China. jianghai@icdc.cn
authors.forename: Hai
authors.initials: H
authors.lastname: Jiang
authors.forename: Mao-Jun
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Rui-Chun
authors.initials: RC
authors.lastname: Liu
authors.forename: Xin-Ying
authors.initials: XY
authors.lastname: Tian
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Gu
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Zhang
mesh_terms: D001483:Base Sequence; D016123:Campylobacter jejuni / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D005798:Genes, Bacterial; D056426:Genetic Loci; D020275:Guillain-Barre Syndrome / Q000382:microbiology; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D008070:Lipopolysaccharides; D009844:Oligosaccharides