title: MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3.
authors.forename: Michele Dal
authors.initials: MD
authors.lastname: Bo
authors.forename: Paola
authors.initials: P
authors.lastname: Secchiero
authors.forename: Massimo
authors.initials: M
authors.lastname: Degan
authors.forename: Daniela
authors.initials: D
authors.lastname: Marconi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bomben
authors.forename: Gabriele
authors.initials: G
authors.lastname: Pozzato
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Del Poeta
authors.forename: Francesco
authors.initials: F
authors.lastname: Forconi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zauli
authors.forename: Valter
authors.initials: V
authors.lastname: Gattei
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018797:Cell Cycle Proteins; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D007093:Imidazoles; C482775:MDM4 protein, human; D009687:Nuclear Proteins; D010879:Piperazines; D011518:Proto-Oncogene Proteins; C482205:nutlin 3