The meniscus, calcification and osteoarthritis: a pathologic team.
Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying agents in OA, which are currently unavailable.
MacMullan
Paul A
PA
McCarthy
Geraldine M
GM
D002114:Calcinosis / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D002130:Calcium Phosphates / Q000378:metabolism; D002131:Calcium Pyrophosphate / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D003460:Crystallization; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism* / Q000503:physiopathology
D002130:Calcium Phosphates; C020243:calcium phosphate; D002118:Calcium; D002131:Calcium Pyrophosphate