title: Dithiolopyrrolone antibiotic formation induced by adding valeric acid to the culture broth of Saccharothrix algeriensis.
abstract: Three new antibiotics were isolated from the fermentation broth of Saccharothrix algeriensis NRRL B-24137 and characterized as the dithiolopyrrolone derivatives valerylpyrrothine (1), isovalerylpyrrothine (2), and formylpyrrothine (3) as well as the known antibiotic aureothricin. The production of the dithiolopyrrolone derivatives was induced by adding valeric acid to the culture medium. The compounds exhibited moderate antimicrobial activity in vitro.
authors.affiliation: Laboratoire de Recherche sur les Produits Bioactifs et la Valorisation de la Biomasse (LPBVB), Ecole Normale Superieure de Kouba, B.P. 92, 16050 Kouba, Alger, Algeria.
authors.forename: Rabiâa
authors.initials: R
authors.lastname: Merrouche
authors.forename: Noureddine
authors.initials: N
authors.lastname: Bouras
authors.forename: Yannick
authors.initials: Y
authors.lastname: Coppel
authors.forename: Florence
authors.initials: F
authors.lastname: Mathieu
authors.forename: Marie-Carmen
authors.initials: MC
authors.lastname: Monje
authors.forename: Nasserdine
authors.initials: N
authors.lastname: Sabaou
authors.forename: Ahmed
authors.initials: A
authors.lastname: Lebrihi
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000187:drug effects; D000462:Algeria; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010421:Pentanoic Acids / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010421:Pentanoic Acids; D011758:Pyrroles; C550899:formylpyrrothine; C550898:isovalerylpyrrothine; C550897:valerylpyrrothine; C038780:n-pentanoic acid