Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa.
Chemical investigation of the soft coral Sinularia gyrosa led to the purification of three new diterpenoids, designated as gyrosanols A-C (1-3). The structures of 1-3 were elucidated through extensive spectroscopic analyses. Compounds 1 and 2 exhibited antiviral activity against HCMV with IC(50)'s of 2.6 and 3.7 microM, respectively. In addition, compounds 1 and 2 showed significant anti-inflammatory activity by reducing the levels of the COX-2 protein (19.6 + or - 3.9% and 29.1 + or - 9.6%, respectively) in RAW 264.7 macrophages.
Cheng
Shi-Yie
SY
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
Chuang
Cheng-Ta
CT
Wang
Shang-Kwei
SK
Wen
Zhi-Hong
ZH
Chiou
Shu-Fen
SF
Hsu
Chi-Hsin
CH
Dai
Chang-Feng
CF
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D021902:Enterobacter aerogenes / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012477:Salmonella enteritidis / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012764:Shigella sonnei / Q000187:drug effects; D015008:Yersinia enterocolitica / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D052246:Cyclooxygenase 2 Inhibitors; D004224:Diterpenes; C550962:gyrosanol A; C550964:gyrosanol B; C550963:gyrosanol C