title: Oxidative stress in benign prostatic hyperplasia and prostate cancer.
abstract: OBJECTIVE
  The aim was to verify whether oxidative stress could represent a common key factor of benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
  
  
  METHODS
  15 patients affected by BPH, 15 with PCa and 15 controls were enrolled. Blood samples were withdrawn systemically and locally during radical retropubic prostatectomy in patients with PCa and during transvesical retropubic adenomectomy in patients diagnosed with BPH. Plasma oxidized low-density lipoprotein, peroxides, and total equivalent antioxidant capacity (TEAC) including plasma superoxide dismutase (SOD) determination were analyzed as oxidative markers.
  
  
  RESULTS
  With respect to the control group, high plasma peroxides and decreased TEAC levels were measured in patients affected by both PCa and BPH. Plasma peroxides were significantly higher in patients with PCa with respect to BPH. A positive correlation was found between peroxides and TEAC values in samples withdrawn locally in patients affected by PCa. An inverse correlation between peroxides and TEAC was observed in patients with BPH. No statistically significant modifications were observed as concerns SOD activity and LDL oxidability.
  
  
  CONCLUSIONS
  Our findings confirm a significant unbalance of redox status in patients affected by BPH and PCa, and suggest a potential involvement of oxidative stress as a determinant in the pathogenesis of these diseases.
authors.affiliation: Department of Health Sciences, University of L'Aquila, L'Aquila, Italy. giannapace @ gmail.com
authors.forename: Gianna
authors.initials: G
authors.lastname: Pace
authors.forename: Caterina
authors.initials: C
authors.lastname: Di Massimo
authors.forename: Daniela
authors.initials: D
authors.lastname: De Amicis
authors.forename: Carlo
authors.initials: C
authors.lastname: Corbacelli
authors.forename: Laura
authors.initials: L
authors.lastname: Di Renzo
authors.forename: Carlo
authors.initials: C
authors.lastname: Vicentini
authors.forename: Lucio
authors.initials: L
authors.lastname: Miano
authors.forename: Maria Giuliana
authors.initials: MG
authors.lastname: Tozzi Ciancarelli
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002138:Calibration; D015331:Cohort Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010545:Peroxides / Q000737:chemistry; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014572:Urology / Q000379:methods*
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D010545:Peroxides; C099252:oxidized low density lipoprotein; D013482:Superoxide Dismutase