A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study.
Previous studies have reported associations of polymorphisms in the IGF1 gene with phenotypes of body composition (BC). The purpose of this study was to identify phenotypes of BC and physical function that were associated with the IGF1 promoter polymorphism (rs35767, -C1245T). Subjects from the Health, Aging, and Body Composition Study, white males and females (n = 925/836) and black males and females (533/705) aged 70-79 years were genotyped for the polymorphism. Phenotypes of muscle size and function, bone mineral density, and BC were analyzed for associations with this polymorphism. To validate and compare these findings, a cohort of young (mean age = 24.6, SD = 5.9) white men and women (n = 173/296) with similar phenotypic measurements were genotyped. An association with BC was identified in elderly females when significant covariates (physical activity, age, smoking status, body mass index) were included. White women with C/C genotype had 3% more trunk fat and 2% more total fat than those with C/T (P < 0.05). Black women with C/C genotype had 3% less total lean mass and 3% less muscle mass than their T/T counterparts (P < 0.05). Associations were identified with muscle strength in white women (P < 0.01) that were in agreement with the C/C genotype having lower muscle function. Thus, in an elderly population but not a young population, a polymorphism in the IGF1 gene may be predictive of differences in body composition, primarily in black females.
Kostek
Matthew C
MC
Department of Exercise Science, University of South Carolina, Columbia, SC, USA.
Devaney
Joseph M
JM
Gordish-Dressman
Heather
H
Harris
Tamara B
TB
Thompson
Paul D
PD
Clarkson
Priscilla M
PM
Angelopoulos
Theodore J
TJ
Gordon
Paul M
PM
Moyna
Niall M
NM
Pescatello
Linda S
LS
Visich
Paul S
PS
Zoeller
Robert F
RF
Seip
Richard L
RL
Garcia
Melissa
M
Li
Rongling
R
Zmuda
Joseph M
JM
Delmonico
Matthew J
MJ
Kanaya
Alka
A
Hoffman
Eric P
EP
D050154:Adiposity / Q000208:ethnology / Q000235:genetics; D001741:Black or African American / Q000235:genetics; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000235:genetics*; D001823:Body Composition / Q000235:genetics*; D015519:Bone Density / Q000235:genetics; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D016018:Least-Squares Analysis; D016013:Likelihood Functions; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D053580:Muscle Strength / Q000235:genetics*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000502:physiology*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D014481:United States; D044465:White People / Q000235:genetics; D055815:Young Adult
D007334:Insulin-Like Growth Factor I