Dietary fumonisin exposure in a rural population of South Africa.
A validated culturally specific dietary assessment method was used to determine the habitual maize intakes of black Xhosa-speaking Africans living in the Centane region of the Eastern Cape Province to assess their exposure to the carcinogenic fumonisin mycotoxins. The mean total dry weight maize intakes of home-grown, commercial or combined (both maize sources) were 474, 344, 462 g day(-1), respectively. When considering the total mean levels of fumonisin in home-grown maize (1142 microg kg(-1)) and commercial maize (222 microg kg(-1)), the probable daily intakes (PDI's), expressed as microg kg(-1) body weight day(-1) were 12.1 (95%CI: 0.3-4926.5) and 1.3 (95%CI: 1.0-1.8) for men and 6.7 (95%CI: 1.0-457.8) and 1.1 (95%CI: 0.9-1.3) for women, consuming home-grown and commercial maize, respectively. Based on the different maize-based beer drinking frequencies the PDI's varied between 6.9 and 12.0 microg kg(-1)/drinking event. Depending on the maize intake patterns an exposure "window" exists where fumonisin exposure is below the recommended group provisional maximum tolerable daily intake (PMTDI) for fumonisins of 2 microg kg(-1)bw day(-1). The assessment of fumonisin exposure and development of preventative strategies depend, not only the accurate determination of total fumonisin levels in maize, but also on the distinct dietary patterns of a specific population.
Burger
H-M
HM
PROMEC Unit, Medical Research Council MRC, PO Box 19070, Tygerberg 7505, South Africa. hburger@mrc.ac.za
Lombard
M J
MJ
Shephard
G S
GS
Rheeder
J R
JR
van der Westhuizen
L
L
Gelderblom
W C A
WC
D000293:Adolescent; D000328:Adult; D000368:Aged; D001515:Beer; D003296:Cooking; D004032:Diet; D004034:Diet Surveys; D005260:Female; D005506:Food Contamination; D037341:Fumonisins / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D013019:South Africa; D055815:Young Adult; D003313:Zea mays / Q000382:microbiology
D037341:Fumonisins