title: Imaging of the host/parasite interplay in cutaneous leishmaniasis.
abstract: An understanding of host-parasite interplay is essential for the development of therapeutics and vaccines. Immunoparasitologists have learned a great deal from 'conventional'in vitro and in vivo approaches, but recent developments in imaging technologies have provided us (immunologists and parasitologists) with the ability to ask new and exciting questions about the dynamic nature of the parasite-immune system interface. These studies are providing us with new insights into the mechanisms involved in the initiation of a Leishmania infection and the consequent induction and regulation of the immune response. Here, we review some of the recent developments and discuss how these observations can be further developed to understand the immunology of cutaneous Leishmania infection in vivo.
authors.affiliation: Centre for Biophotonics, University of Strathclyde, Glasgow G4 0NR, UK. owain.millington@strath.ac.uk
authors.forename: Owain R
authors.initials: OR
authors.lastname: Millington
authors.forename: Elmarie
authors.initials: E
authors.lastname: Myburgh
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Mottram
authors.forename: James
authors.initials: J
authors.lastname: Alexander
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology; D007891:Leishmania / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000469:parasitology* / Q000628:therapy; D049449:Luminescence; D008856:Microscopy, Fluorescence; D010588:Phagosomes / Q000469:parasitology; D016052:Protozoan Vaccines
chemical_list: D016052:Protozoan Vaccines