title: Single-file diffusion of protein drugs through cylindrical nanochannels.
abstract: A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant in vivo release of hGH from the drug delivery nanodevice implanted to Sprague-Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs.
authors.affiliation: National Creative Research Center for Block Copolymer Self-Assembly, Department of Environmental Science & Engineering, Pohang University of Science and Technology, Kyungbuk, Korea.
authors.forename: Seung Yun
authors.initials: SY
authors.lastname: Yang
authors.forename: Jeong-A
authors.initials: JA
authors.lastname: Yang
authors.forename: Eung-Sam
authors.initials: ES
authors.lastname: Kim
authors.forename: Gumhye
authors.initials: G
authors.lastname: Jeon
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Oh
authors.forename: Kwan Yong
authors.initials: KY
authors.lastname: Choi
authors.forename: Sei Kwang
authors.initials: SK
authors.lastname: Hahn
authors.forename: Jin Kon
authors.initials: JK
authors.lastname: Kim
mesh_terms: D000818:Animals; D002417:Cattle; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold / Q000737:chemistry; D019382:Human Growth Hormone / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D007267:Injections; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D016062:Porosity; D011506:Proteins / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D011137:Polystyrenes; D011506:Proteins; D019382:Human Growth Hormone; D012710:Serum Albumin, Bovine; D006046:Gold; D019904:Polymethyl Methacrylate