Association of environmental toxic elements in biological samples of myocardial infarction patients at different stages.
The exposure of toxic elements may directly or indirectly associate with different pathogenesis of heart diseases. In the present study, the association of arsenic (As), cadmium (Cd), cobalt (Co), lead (Pb), and nickel (Ni) in biological samples (whole blood and urine) and mortality from myocardial infarction (MI) patients at first, second, and third heart attacks was carried out. Both biological samples of 130 MI patients (77 male and 53 female), with ages ranging from 45 to 60 years, and 61 healthy persons (33 male and 28 female) of the same age group were collected. The elements in biological samples were assessed by electrothermal atomic absorption spectrophotometer, prior to microwave-assisted acid digestion. The validity of methodology was checked by the biological certified reference materials. During this study, 78% of 32 patients aged above 50 years, registered after third MI attack, died. In these subjects, the levels of As, Cd, Co, Ni, and Pb in blood samples were higher in MI patients as compared with referents (p < 0.05), while increased by 11.7%, 12.2%, 5.55%, and 7.2%, respectively, in the blood samples of those patients who tolerated the third MI attack (p = 0.12). The high level of understudied toxic elements may play a role in the mortality of MI patients.
Afridi
Hassan Imran
HI
National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
Kazi
Tasneem Gul
TG
Kazi
Naveed
N
Kandhro
Ghulam Abbas
GA
Baig
Jameel Ahmed
JA
Jamali
Mohammad Khan
MK
Arain
Mohammad Balal
MB
Shah
Abdul Qadir
AQ
Shah
Faheem
F
Khan
Sumaira
S
Kolachi
Nida Fatima
NF
D004785:Environmental Pollutants / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000097:blood* / Q000652:urine; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000652:urine; D012727:Sex Characteristics; D014131:Trace Elements / Q000097:blood* / Q000652:urine
D004785:Environmental Pollutants; D019216:Metals, Heavy; D014131:Trace Elements