title: Myoepithelial carcinoma of intraoral minor salivary glands: a clinicopathological study of 7 cases and review of the literature.
abstract: OBJECTIVE
  Myoepithelial carcinoma (MC), also known as malignant myoepithelioma, is a rare malignant salivary gland neoplasm with a predilection for the parotid gland. We present the clinicopathological and immunohistochemical features of 7 cases of intraoral MC in attempt to better understanding this entity.
  
  
  METHODS
  Seven intraoral MCs were retrieved from the files of the Department of Oral Pathology, School of Stomatology, Wuhan University, during a 10-year period. Immunohistochemical markers, including cytokeratin (CK) AE1/AE3, S100, vimentin, smooth muscle actin (SMA), p63, and maspin, were used to further characterize these lesions. A review of contemporary relevant literature is also provided.
  
  
  RESULTS
  The patients were 5 women and 2 men, and the age range was 37 to 75 years (mean 57.9 years). Three cases arose in the hard palate, 2 in the retromolar region, and 1 each in the tongue and the floor of the mouth. Histologically, the tumors exhibited a solid architecture with cells arranged in nodules, nests, trabeculae, or cords. The epithelioid cell type is the most frequently encountered, followed by clear cells. The tumor-associated matrix is more prevalent hyalinized than myxoid. Immunohistochemically, CK AE1/AE3, S100, vimentin, p63, and maspin were expressed in all cases. Positivity for SMA was seen in 3 tumors. Five patients with follow-up information showed no evidence of disease after a mean follow-up of 69.6 months (range 22-108 months).
  
  
  CONCLUSIONS
  Combining the current series with 21 additional cases in the literature indicated that myoepithelial carcinoma of intraoral minor salivary glands is generally a low-grade malignant tumor with little propensity for regional or distant metastasis and low recurrence. Awareness of the clinicopathological and immunohistochemical features of intraoral MC is necessary for accurate diagnosis. Wide local excision with tumor-free margins is the treatment of choice.
authors.affiliation: Department of Oral Histopathology, Faculty of Stomatology, Hainan Medical College, Haikou, Hainan, China.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Yang
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Zeng
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Zhu
authors.forename: Jiali
authors.initials: J
authors.lastname: Zhang
authors.forename: Xinming
authors.initials: X
authors.lastname: Chen
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000175:diagnosis*; D037981:Neck Dissection; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*; D012470:Salivary Glands, Minor / Q000473:pathology*; D015842:Serine Proteinase Inhibitors / Q000032:analysis; D015843:Serpins / Q000032:analysis; D015534:Trans-Activators / Q000032:analysis; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D009418:S100 Proteins; C085344:SERPIN-B5; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D014746:Vimentin; D007633:Keratins