title: Influence of polyhydramnios on perinatal outcome in pregestational diabetic pregnancies.
abstract: OBJECTIVE
  This study was carried out to evaluate the perinatal outcomes of pregnancy with pregestational diabetes mellitus complicated by polyhydramnios.
  
  
  METHODS
  This was a retrospective study of singleton pregnancies, with an antepartum diagnosis of polyhydramnios, seen at the maternal fetal medicine department of Mater Mothers' Hospital, a tertiary-level facility. All pregnancies in women with pregestational diabetes with a singleton pregnancy beyond 24 weeks of gestation, from 1996 to 2006, were reviewed (n = 314), and pregnancies complicated by polyhydramnios were identified (n = 59). Pregnancy outcomes of women whose pregnancy was complicated with polyhydramnios were compared to those without this complication.
  
  
  RESULTS
  The incidence of polyhydramnios in the study population was 18.8%. Women with polyhydramnios had increased hemoglobin A1c (HbA1c) levels throughout the pregnancy, and the difference was significant during the prepregnancy period and in the third trimester (P = 0.003 and P = 0.025, respectively). Significantly more mothers in the polyhydramnios group delivered preterm (54.2% vs. 33.3%, P = 0.004), the majority of which were iatrogenic preterm deliveries (44.1%). More pregnancies with polyhydramnios were delivered by Cesarean section (83.0% vs. 62%; P = 0.006), with the majority being performed electively in both groups (79.6% and 70.3%, respectively). Regardless, there were no significant differences in perinatal mortality rates, congenital abnormality rates, the incidences of low Apgar score, acidemia, hypoglycemia requiring intravenous therapy, phototherapy and ventilatory needs between the babies of the two groups.
  
  
  CONCLUSIONS
  Pregestational diabetic pregnancy with polyhydramnios is associated with poor diabetic control. Despite this, there is no significant increase in adverse perinatal outcome in these pregnancies, apart from a higher iatrogenic preterm birth rate.
authors.affiliation: Department of Maternal Fetal Medicine, University of Queensland, Mater Mothers' Hospital, South Brisbane, QLD, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Idris
authors.forename: S F
authors.initials: SF
authors.lastname: Wong
authors.forename: M
authors.initials: M
authors.lastname: Thomae
authors.forename: G
authors.initials: G
authors.lastname: Gardener
authors.forename: D H
authors.initials: DH
authors.lastname: McIntyre
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006831:Polyhydramnios / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human