[Deep brain stimulation for neurological and psychiatric diseases: animal experiments on effect and mechanisms].
Deep brain stimulation at high frequencies has emerged as a powerful therapeutic strategy in the treatment of basal ganglia-related movement disorders. Attempts have also been made to establish this for the treatment of therapy-resistant psychiatric disorders. To date the mechanisms underlying the clinical efficacy of high frequency stimulation remain largely unknown. Their detailed description, however, is essential for promoting the extended application of high frequency stimulation as a therapeutic alternative and may simultaneously allow conclusions to be drawn on the pathophysiological mechanisms underlying the diseases benefiting from deep brain stimulation. This review demonstrates how animal models contribute to i) further understand the mechanisms underlying deep brain stimulation at high frequencies and ii) promote the establishment of high frequency stimulation for the treatment of therapy-resistant psychiatric disorders.
Winter
C
C
Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstrasse 74, Dresden, Germany. Christine.Winter@uniklinikum-dresden.de
Harnack
D
D
Kupsch
A
A
D000818:Animals; D001480:Basal Ganglia Diseases / Q000503:physiopathology / Q000628:therapy; D001931:Brain Mapping / Q000295:instrumentation; D002908:Chronic Disease; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004567:Electrodes, Implanted; D005917:Globus Pallidus / Q000503:physiopathology; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology* / Q000628:therapy*; D008904:Miniaturization / Q000295:instrumentation; D009069:Movement Disorders / Q000503:physiopathology* / Q000628:therapy*; D009714:Nucleus Accumbens / Q000503:physiopathology; D020734:Parkinsonian Disorders / Q000503:physiopathology / Q000628:therapy; D051381:Rats; D020531:Subthalamic Nucleus / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology
D004298:Dopamine