The cyclic organosulfur compound zwiebelane A from onion (Allium cepa) functions as an enhancer of polymyxin B in fungal vacuole disruption.
Zwiebelane A (CIS-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl sulfur compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.
Borjihan
Baiyinlang
B
Department of Bio- and Geosciences, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, Japan.
Ogita
Akira
A
Fujita
Ken-ichi
K
Doe
Matsumi
M
Tanaka
Toshio
T
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D004357:Drug Synergism; D019697:Onions / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots; D011112:Polymyxin B / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D014617:Vacuoles / Q000187:drug effects*
D000935:Antifungal Agents; D053961:Azabicyclo Compounds; D010936:Plant Extracts; C557804:zwiebelane A; D011112:Polymyxin B