title: Correlation between genetic HLA class I and II polymorphisms and anthropological aspects in the Chaouya population from Morocco (Arabic speaking).
abstract: The aim of this study was to provide genetic and anthropological information on the Chaouya (CH), an Arabic-speaking population living in West Morocco, Atlantic coast (Settat). In 98 unrelated healthy CH volunteers, we first investigated the human leukocyte antigen (HLA) class I and II allele polymorphisms using a sequence-based typing method and examined haplotypes and relatedness of this group to other African and Mediterranean populations. The study showed the close relatedness with Tunisian population and other North Africans, together with a strong influence of various immigrations, mainly Spaniards, French, and Portuguese, as expected. Nevertheless, analysis of class II allele frequencies (afs) showed that Oromo and Amhara Ethiopian groups cluster together with the Berbers and other North Africans, confirming the relationship between these populations (Afro-Asiatic linguistic group, Hamites). South and sub-Saharan Africans cluster separately at a great distance from CH, except the sub-Saharan Bantu population from Congo Kinshasa, which shows a relatively close genetic relationship ascribable to the effect of a diversifying selection. On the other hand, considering HLA class I afs analyses, it was noteworthy that CH grouped together with sub-Saharans, showing a close genetic distance mainly with Ugandas and Kenians Luo.
authors.affiliation: CNR Institute Organ Transplants and Immunocitology, L'Aquila, Italy. angelica.canossi@cnr.it
authors.forename: A
authors.initials: A
authors.lastname: Canossi
authors.forename: D
authors.initials: D
authors.lastname: Piancatelli
authors.forename: A
authors.initials: A
authors.lastname: Aureli
authors.forename: K
authors.initials: K
authors.lastname: Oumhani
authors.forename: G
authors.initials: G
authors.lastname: Ozzella
authors.forename: T
authors.initials: T
authors.lastname: Del Beato
authors.forename: G
authors.initials: G
authors.lastname: Liberatore
authors.forename: R
authors.initials: R
authors.lastname: El Aouad
authors.forename: D
authors.initials: D
authors.lastname: Adorno
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000885:Anthropology, Physical; D044383:Black People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D010802:Phylogeny; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II