Tocilizumab for the treatment of rheumatoid arthritis.
Tocilizumab is a humanized anti-human IL-6 receptor antibody that specifically inhibits the biological activity of IL-6 by competitively inhibiting the binding of IL-6 to the IL-6 receptor. Clinical trials have shown that tocilizumab 8 mg/kg administered by monthly infusion not only improves clinical signs and symptoms of refractory rheumatoid arthritis but also suppresses radiographic progression. In regard to safety, the most common adverse event was nonsevere infection, such as nasopharyngitis, although the incident rate of adverse events was slightly higher than that of disease-modifying antirheumatic drug treatment. Studies have shown that there is no specific infection or prolongation of infection related to tocilizumab treatment. Tocilizumab is a promising therapeutic agent with statisfactory efficacy and safety for rheumatoid arthritis.
Mima
Toru
T
Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3, Yamada-Oka, Suita-City, Osaka 565-0871, Japan. mimat@fbs.osaka-u.ac.jp
Nishimoto
Norihiro
N