title: Serum platelet-activating factor acetylhydrolase activity: relationship with metabolic syndrome in women with history of gestational diabetes mellitus.
abstract: OBJECTIVE
  The aim of this study was to evaluate plasma platelet-activating factor acetylhydrolase (PAF-AH) activity in euglycaemic women with history of gestational diabetes (GDM), and to explore whether this activity is associated with metabolic syndrome (MS) in this group of women.
  
  
  METHODS
  The cross-sectional study included 36 women with history of GDM and 40 women with history of normal glucose tolerance in pregnancy (control group).
  
  
  RESULTS
  Compared to the controls, the GDM group had significantly higher mean values for serum glucose, insulin, HOMA-IR, triglyceride, GGT and plasma PAF-AH activity, and a statistically higher prevalence of MS. Within the GDM group, women diagnosed with MS had significantly higher PAF-AH activity than those without MS (p=0.002).
  
  
  CONCLUSIONS
  This is the first study to have shown that plasma PAF-AH activity and GGT levels may be significant for evaluating atherosclerosis risk and metabolic hepatic damage in women with history of GDM.
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University School of Medicine, Ankara, Turkey. ayseluysal@hotmail.com
authors.forename: Aysel
authors.initials: A
authors.lastname: Derbent
authors.forename: Ayse
authors.initials: A
authors.lastname: Kargili
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
authors.forename: Ilknur İnegöl
authors.initials: Iİ
authors.lastname: Gümüş
authors.forename: Sema
authors.initials: S
authors.lastname: Sevgili
authors.forename: Serap
authors.initials: S
authors.lastname: Simavli
authors.forename: Feridun
authors.initials: F
authors.lastname: Karakurt
authors.forename: Nilgün Öztürk
authors.initials: NÖ
authors.lastname: Turhan
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood* / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D011247:Pregnancy; D015995:Prevalence; D017584:Reproductive History; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase