Gestational diabetes insipidus: a review of an underdiagnosed condition.
OBJECTIVE
To review the etiology, diagnosis, and management of diabetes insipidus during pregnancy.


METHODS
A search of the literature was performed in PubMed using key word searching and citation snowballing to identify articles published in English between January 1, 1980, and December 31, 2008, on the subject of diabetes insipidus during pregnancy. Once the articles were identified, a thorough review of all results was conducted. Results and conclusions were compiled and summarized.


METHODS
We reviewed 50 studies selected using the following key words: diabetes insipidus, pregnancy, arginine vasopressin, vasopressinase.


CONCLUSIONS
Gestational diabetes insipidus is underdiagnosed because polyuria is often considered normal during pregnancy. Clinicians caring for pregnant women should consider screening for gestational diabetes insipidus, because it could be associated with serious underlying pathology.
Aleksandrov
Nikolay
N
Department of Obstetrics and Gynecology, University of Montreal, Montreal QC.
Audibert
François
F
Bedard
Marie-Josée
MJ
Mahone
Michèle
M
Goffinet
François
F
Kadoch
Isaac-Jacques
IJ
D050034:Antidiuretic Agents / Q000627:therapeutic use; D001834:Body Water / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D016640:Diabetes, Gestational / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D010904:Pituitary Gland, Posterior / Q000033:anatomy & histology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016216:Ultrasonography, Prenatal; D014667:Vasopressins / Q000378:metabolism
D050034:Antidiuretic Agents; D004232:Diuretics; D006852:Hydrochlorothiazide; D014667:Vasopressins; D003894:Deamino Arginine Vasopressin