Review for disease of the year: immunopathogenesis of ocular sarcoidosis.
Ocular sarcoidosis is a heterogeneous disease having varied presentations and severities with genetic susceptibility playing a role. Sarcoidosis is characterized by the presence of noncaseating (non-necrotizing) granulomas in the affected organs or tissue systems. What causes these granulomas is not known, but current knowledge of the immunology of this enigmatic disease centers on a CD4 T helper type 1 cell response. This review deals with immunologic sequences that lead to the formation of sarcoid granulomas and explores the immunopathogenesis of ocular inflammation seen in patients with sarcoidosis.
Chan
Anita S Y
AS
Doheny Eye Institute, California, USA.
Sharma
Om P
OP
Rao
Narsing A
NA
D016207:Cytokines / Q000276:immunology; D005128:Eye Diseases / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D012507:Sarcoidosis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
D016207:Cytokines