title: Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens.
abstract: Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It was observed that two of the synthesized compounds exhibited relatively good antibacterial and antifungal activities.
authors.affiliation: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Arumugam
authors.forename: Raghavachary
authors.initials: R
authors.lastname: Raghunathan
authors.forename: Vellaisamy
authors.initials: V
authors.lastname: Shanmugaiah
authors.forename: Narayanasamy
authors.initials: N
authors.lastname: Mathivanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000382:microbiology; D013141:Spiro Compounds / Q000138:chemical synthesis; D013329:Structure-Activity Relationship; D044024:Tetralones / Q000138:chemical synthesis* / Q000494:pharmacology; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002839:Chromans; D007555:Isoxazoles; D013141:Spiro Compounds; D044024:Tetralones; D047090:beta-Lactams