A call to arms: interferons prepare bone marrow cells to battle peripheral infections.
Viral infection leads to the rapid production of type I interferons within infected tissues. In this issue of Cell Host & Microbe, Hermesh et al. (2010) demonstrate that interferons produced following respiratory viral infection program leukocytes in the bone marrow to resist infection before trafficking to the lung.
Kohlmeier
Jacob E
JE
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.
Woodland
David L
DL