title: Bilateral testicular metastasis from prostatic adenocarcinoma mimicking an intertubular pattern of seminoma and expressing Rhamm.
abstract: Adenocarcinoma of prostate metastasizing to testis is a rare occurrence and is incidentally detected in orchiectomy specimens. The pattern of metastasis may mimic a primary neoplasm of testis like a seminoma or lymphoma and pose a diagnostic difficulty for the pathologist. A rare case of bilateral testicular metastasis of prostatic adenocarcinoma is presented wherein the metastatic cells expressed CD168, a receptor for hyaluronan mediated motility (Rhamm), implicated in the development of androgen independence in prostate cancer.
authors.affiliation: Department of Pathology, Tata Memorial Hospital, Parel, Mumbai- 400 012, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Menon
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gujral
authors.forename: Ganesh
authors.initials: G
authors.lastname: Bakshi
authors.forename: Hemant B
authors.initials: HB
authors.lastname: Tongaonkar
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D016729:Leuprolide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D018239:Seminoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D036761:Ultrasound, High-Intensity Focused, Transrectal
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; C098946:hyaluronan-mediated motility receptor; D016729:Leuprolide