[Chromosome abnormalities and congenital heart diseases: a retrospective on 49 cases].
OBJECTIVE
To investigate the association between congenital heart diseases and chromosome abnormalities.


METHODS
Patients with congenital heart diseases who underwent chromosome examinations during Jan 2006 and Dec. 2009 in the Center of Prenatal Diagnosis of Beijing University People's Hospital were recruited in the study. The association between chromosome karyotypes and types of congenital heart diseases was analyzed.


RESULTS
Among the 49 patients with congenital heart diseases, trisomy 21 was established in 11 cases, trisomy 18 in 6 cases, trisomy 13 in 6 cases, trisomy 14 in 1 cases, trisomy 16 in 3 cases, trisomy 8 in 1 cases, trisomy 22 in 1 cases, sex chromosomal abnormalities in 8 cases, triploid in 2 cases, partial chromosomal trisomy in 8 cases, and 46,XX/XY, 5p-- in 2 cases.


CONCLUSIONS
Chromosome abnormalities are associated with congenital heart diseases. Different abnormal chromosome karyotypes contribute to different types of congenital heart diseases. Prenatal chromosome examinations could be undertaken to detect congenital heart diseases.
Zhang
Lin
L
The Center of Prenatal Diagnosis, Beijing University People's Hospital, Beijing 100044, China.
Zhang
Xiao-hong
XH
Ren
Mei-hong
MH
Song
Gui-ning
GN
D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis*; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D012189:Retrospective Studies; D014314:Trisomy / Q000175:diagnosis; D000073839:Trisomy 13 Syndrome; D014463:Ultrasonography; D055815:Young Adult