Schistocytic hemolytic anemia owing to central venous catheter in a child with acute lymphoblastic leukemia.
A 4-year-old boy with acute lymphoblastic leukemia (ALL) was inserted a central venous catheter into right vena jugularis interna, whereas on BFM-ALL (Protocol 1) therapy. He developed progressive anemia, thrombocytopenia, schistocytes with triangular or crescent shapes, microspherocytes and teardrop cells in the peripheric blood smear, elevated lactate dehydrogenase, and decreased haptoglobin. Schistocytic hemolytic anemia was considered. On chest radiogram, the central venous catheter (CVC) tip was seen beneath the expected location. An echocardiography revealed that CVC was within the right atrium, in contact with tricuspite leaflets. So, CVC was overhauled and a new one was inserted. After the revision, hemolysis ceased; haptoglobin level normalized.
Oztürkmen
Seda
S
Department of Pediatric Hematology, Dr AY Ankara Oncology Training and Research Hospital, Ankara, Turkey.
Paç
Ayşenur
A
Senayl
Atilla
A
Polat
Tuğçin Bora
TB
Cetin
Ibrahim Ilker
II
Bçakç
Zafer
Z
Akyay
Arzu
A
Olcay
Lale
L
D000743:Anemia, Hemolytic / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002675:Child, Preschool; D003630:Daunorubicin / Q000627:therapeutic use; D004912:Erythrocytes / Q000473:pathology*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin