title: A non-invasive thymoma that occurred 29 years after complete resection of a non-invasive thymoma accompanied by a microthymoma.
abstract: A 55-year-old woman with a 7 cm non-invasive thymoma and myasthenia gravis had been treated by extended thymectomy via median sternotomy 29 years ago. A microscopic 0.15 cm thymoma (microthymoma) was incidentally found in the thymus during surgery. Twenty-nine years later, a 5 cm thymoma developed in the anterior mediastinum and was surgically treated. The non-invasive first thymoma, the microthymoma and the non-invasive third thymoma were all classified as type AB thymomas according to the World Health Organization (WHO) classification and showed extremely similar histological findings. We think the mechanism underlying the local recurrence of non-invasive thymomas would be intrathymic metastasis because of their clinical and pathological features.
authors.affiliation: Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. yoshikaney@2004.jukuin.keio.ac.jp
authors.forename: Yoshikane
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Mitsutomo
authors.initials: M
authors.lastname: Kohno
authors.forename: Tai
authors.initials: T
authors.lastname: Hato
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Izumi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nomori
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D056346:Sternotomy / Q000379:methods; D013934:Thymectomy / Q000379:methods; D013945:Thymoma / Q000145:classification / Q000150:complications / Q000601:surgery*; D013950:Thymus Gland / Q000473:pathology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000145:classification / Q000150:complications / Q000601:surgery*; D014944:World Health Organization