Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid.
(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
Meinerz
Daiane Francine
DF
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, RS, Brazil.
Sudati
Jéssie H
JH
dos Santos
Danúbia B
DB
Frediani
Andressa
A
Alberto
Eduardo E
EE
Allebrandt
Josiane
J
Franco
Jeferson L
JL
Barbosa
Nilda B V
NB
Aschner
Michael
M
da Rocha
João Batista T
JB
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D020552:Comet Assay; D004249:DNA Damage; D005296:Ferrous Compounds / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000494:pharmacology* / Q000633:toxicity; D013691:Tellurium / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D005296:Ferrous Compounds; D009942:Organometallic Compounds; D013386:Succinates; D017392:Thiobarbituric Acid Reactive Substances; C557512:dimethyl 2-(3-(phenyltellanyl)propanamido)succinate; D001224:Aspartic Acid; D005979:Glutathione Peroxidase; D013691:Tellurium