Pigment epithelium-derived factor expression in colorectal cancer patients.
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p < .001) of PEDF in the CRC patient group (1.6 μg/mL) than in of a healthy control group (3.6 μg/mL). A single nucleotide polymorphism (rs1136287, T>C) was screened. In the control group, the CC genotype showed 30% lower PEDF plasma levels compared with the TT genotype (p < .01), whereas the CRC patients failed to show any association regarding these genotypes.
Wågsäter
Dick
D
Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Löfgren
Sture
S
Zar
Niklas
N
Hugander
Anders
A
Dimberg
Jan
J
D019943:Amino Acid Substitution; D020533:Angiogenesis Inhibitors / Q000235:genetics; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008715:Methionine / Q000235:genetics; D009414:Nerve Growth Factors / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011480:Protease Inhibitors / Q000097:blood; D012016:Reference Values; D015843:Serpins / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D013912:Threonine / Q000235:genetics; D000099174:Pigment Epithelium-Derived Factor
D020533:Angiogenesis Inhibitors; D004273:DNA, Neoplasm; D005136:Eye Proteins; D015850:Interleukin-6; D008715:Methionine; D009414:Nerve Growth Factors; D011480:Protease Inhibitors; D015843:Serpins; D013912:Threonine; D000099174:Pigment Epithelium-Derived Factor