Mathematical models of canine right and left atria cardiomyocytes.
The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria. The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche (RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data. A model of right atria was then built by considering the differences between right atria and left atria. The two developed models well reproduced the experimental data on action potential morphology, the rate dependence, and action potential duration restitution. They are useful for investigating the mechanisms underlying the heterogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.
Xia
Ling
L
Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China. xialing@zju.edu.cn
Gong
Ying-lan
YL
Zhu
Xiu-wei
XW
Zhang
Yu
Y
Sun
Qi
Q
Zhang
Heng-gui
HG
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D016275:Atrial Function; D001683:Biological Clocks / Q000502:physiology*; D002478:Cells, Cultured; D003198:Computer Simulation; D004285:Dogs; D005260:Female; D006329:Heart Conduction System / Q000502:physiology*; D008297:Male; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*