title: A prospective cohort study of the incidence and determinants of post-stroke depression among the mainland Chinese patients.
abstract: BACKGROUND
  Post-stroke depression is a common consequence of stroke and can negatively affect the rehabilitation process in patients. This work was undertaken to examine the incidence, demographic factors and clinical determinants of post-stroke depression in 3 months after ischemic stroke in mainland Chinese patients.
  
  
  METHODS
  One hundred and sixty-five patients with acute ischemic stroke were included in the present work. The Diagnostic and Statistical Manual of Mental Disorders (fourth edition) diagnosis of post-stroke depression was evaluated by the World Health Organization Composite International Diagnostic Interview during the follow-up exam at 3 months after the stroke. The demographic factors and clinical variables at the time of stroke onset and 14 days after stroke were also examined.
  
  
  RESULTS
  The 3 month cumulative incidence of post-stroke depression was 27.3% in this patient population. The univariate analysis suggests that the female gender, past history of depression, marital status and level of handicap at 14 days after stroke were factors associated with the development of post-stroke depression. In the multivariate model, female gender [p=0.0040; odds ratio (OR)=3.550; 95% confidence interval (CI): 1.499-8.408], past history of depression (p=0.0010; OR=5.225; 95% CI: 1.959-13.940) and level of handicap at 14 days after stroke (p=0.0066; OR=1.607; 95% CI: 1.141-2.262) were further confirmed as demographic and clinical factors that correlate with the development of post-stroke depression.
  
  
  CONCLUSIONS
  The present work suggests that female gender, history of depression and level of handicap at 14 days after stroke are three independent determinants of post-stroke depression occurrence during the first 3 months after ischemic stroke in mainland Chinese patients.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D015331:Cohort Studies; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology* / Q000523:psychology*