title: Effect of pretreatment prednisolone on postendodontic pain: a double-blind parallel-randomized clinical trial.
abstract: BACKGROUND
  Effective management of endodontic pain represents a continuing challenge. This study evaluates the use of a preoperative, single oral dose of prednisolone for the prevention and control of postendodontic pain.
  
  
  METHODS
  Forty patients were randomly assigned to 2 groups, placebo and prednisolone (30 mg). The medications were administered 30 minutes before the start of standard endodontic treatment. Postoperative pain was assessed after 6, 12, and 24 hours by using a visual analogue scale.
  
  
  RESULTS
  The outcome showed that prednisolone resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 hours (P < .0001). No side effects were reported for any of the medications used.
  
  
  CONCLUSIONS
  This study suggests that a preoperative, single oral dose of prednisolone substantially reduced postendodontic pain. Further studies are needed to evaluate the applicability of these findings to other clinical conditions, single- versus multiple-visit endodontic treatment, and drug regimens.
authors.affiliation: Department of Endodontics, University of Medical Sciences, Hamadan, Iran.
authors.forename: Seyed Mohsen
authors.initials: SM
authors.lastname: Jalalzadeh
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mamavi
authors.forename: Shahriar
authors.initials: S
authors.lastname: Shahriari
authors.forename: Fábio André
authors.initials: FA
authors.lastname: Santos
authors.forename: Márcia Thaís
authors.initials: MT
authors.lastname: Pochapski
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001729:Bismuth / Q000627:therapeutic use; D004311:Double-Blind Method; D004853:Epoxy Resins / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006171:Gutta-Percha / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010919:Placebos; D011239:Prednisolone / Q000627:therapeutic use*; D011292:Premedication; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012390:Root Canal Therapy / Q000009:adverse effects*; D012834:Silver / Q000627:therapeutic use; D014025:Titanium / Q000627:therapeutic use; D019553:Tooth, Nonvital / Q000628:therapy; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D004853:Epoxy Resins; D005938:Glucocorticoids; D010919:Placebos; D012387:Root Canal Filling Materials; D012834:Silver; C028044:epoxy resin AH-26; D006171:Gutta-Percha; D011239:Prednisolone; D014025:Titanium; D001729:Bismuth