title: A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis.
abstract: Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.
authors.affiliation: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: Livia Cristina Liporagi
authors.initials: LC
authors.lastname: Lopes
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Guimarães
authors.forename: Mariana Duarte
authors.initials: MD
authors.lastname: de Cerqueira
authors.forename: Beatriz L
authors.initials: BL
authors.lastname: Gómez
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D006658:Histoplasma / Q000187:drug effects / Q000254:growth & development / Q000276:immunology*; D006660:Histoplasmosis / Q000188:drug therapy* / Q000276:immunology; D054884:Host-Pathogen Interactions; D007074:Immunoglobulin G; D007167:Immunotherapy / Q000379:methods; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D015996:Survival Rate; D017211:Treatment Failure
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D008565:Membrane Proteins