The relationship between serum visfatin, adiponectin, and insulin sensitivity markers in neonates after birth.
OBJECTIVE
The aim of this study was to assess the adiponectin and visfatin concentrations in small-for-gestational age (SGA), appropriate-for-gestational age (AGA), and large-for-gestational age (LGA) newborns and their mothers. Sixty parturients giving birth to 20 term AGA singleton infants, 20 term singleton SGA infants, and 20 term singleton LGA infants were included into the study.


RESULTS
Mean visfatin levels were found significantly higher in the SGA (p < 0.001) and LGA (p < 0.001) groups, and adiponectin levels were found significantly lower in the SGA group (p < 0.001) when compared with the AGA group. The SGA and LGA groups had higher insulin concentrations and HOMA-IR in comparison with the AGA group. The visfatin, glucose levels, and HOMA-IR (p < 0.001, p < 0.001, and p: 0.002, respectively) were higher in the LGA group than SGA group.


CONCLUSIONS
We found significantly higher insulin and visfatin levels in LGA neonates and lower adiponectin levels in SGA neonates. We concluded that the relationship between adiponectin and visfatin and insulin sensitivity (metabolic disturbances) is very complex with little evidence of correlation in SGA and LGA neonates.
Meral
Cihan
C
Department of Pediatrics, GATA Medical Faculty, Istanbul, Turkey.
Cekmez
Ferhat
F
Pirgon
Ozgur
O
Asya Tanju
Ilhan
I
Metin Ipcioglu
Osman
O
Karademir
Ferhan
F
Gocmen
Ismail
I
D052242:Adiponectin / Q000097:blood; D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*
C499918:ADIPOQ protein, human; D052242:Adiponectin; D054409:Nicotinamide Phosphoribosyltransferase