The new H1N1 and HPV vaccines and old fears.
OBJECTIVE
Vaccines remain an effective yet controversial method for preventing infectious diseases like those caused by human papillomavirus (HPV) and pandemic influenza (H1N1). However, reports of postvaccination serious adverse events such as autoimmunity, although rare, have caused great concerns among the general public. We aimed to summarize the recent knowledge regarding such interactions, mainly focusing on these new vaccines.


RESULTS
Autoimmune phenomena have been associated with specific vaccines, and mechanisms for how this occurs have been elucidated for different vaccine components like the infectious antigen and adjuvant. New vaccines that include infrequently used or new adjuvants have been introduced for both HPV and the H1N1-pandemic influenza. Additionally, two formulations have been approved for use against HPV, and various formulations for the H1N1 influenza vaccine. Whereas preliminary studies are successful, early and late postimmunization events and differences between reagents must be followed closely, especially during mass immunization programs.


CONCLUSIONS
As more diseases are found to be preventable through vaccination, it is of great importance to design better, more effective and better tolerated vaccines. This goal may be achieved utilizing improved vaccine components and a postmarketing system that may allow detection of rare postvaccination phenomena.
Balofsky
Ari
A
Zabludowicz Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
Agmon-Levin
Nancy
N
Shoenfeld
Yehuda
Y
D006801:Humans; D017589:Immunization Programs; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects*; D053918:Papillomavirus Vaccines / Q000009:adverse effects*
D007252:Influenza Vaccines; D053918:Papillomavirus Vaccines