title: [The impact of premature rupture of membranes (PROM) on neonatal outcome].
abstract: OBJECTIVE
  The aim of the following study was to evaluate the impact of premature rupture of membranes (PROM) on neonatal outcome, particularly on the incidence of intrauterine infections (IUI).
  
  
  METHODS
  The study included 428 newborns, born after PROM and hospitalized in the Department of Neonatology at Poznan University of Medical Sciences in 2006. The influence of selected variables on the development of IUI and other complications was analyzed.
  
  
  RESULTS
  IUI occurred in 124 newborns (29%). The odds ratio (OR) of IUI incidence increased with decreasing gestational age, birth weight and Apgar score, as well as with increasing duration of the time between PROM and birth, called the latency period. Logistic regression showed that IUI was significantly influenced by the latency period (OR=1.37; 95% CI: 1.10-1.71; p<0.01), gestational age (OR=2.29; 95% CI: 1.59-3.30; p<0.0001) and 5-minute Apgar score (OR=2.50; 95% CI: 1.57-3,98; p<0.001). The incidence of other complications such as prematurity respiratory distress syndrome, respiratory failure, intraventricular hemorrhage, and anemia increased with the duration of the latency period. Compared to uninfected infants, the infected ones were characterized by lower birth weight, lower gestational age, lower Apgar score and poorer laboratory results.
  
  
  CONCLUSIONS
  Among neonates born from pregnancies complicated with PROM, the incidence of IUI is significantly influenced by the latency period, gestational age and 5-minute Apgar score. The incidence of other complications increases with the duration of the latency period. Prematurity is an important contributor to morbidity in this group of neonates.
authors.affiliation: Studenckie Koło Naukowe Medycyny Perinatalnej, Uniwersytet Medyczny w Poznaniu.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Plucińska
authors.forename: Maria
authors.initials: M
authors.lastname: Hajduczenia
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pastusiak
authors.forename: Marta
authors.initials: M
authors.lastname: Kowalik
authors.forename: Izabela
authors.initials: I
authors.lastname: Miechowicz
authors.forename: Marta
authors.initials: M
authors.lastname: Szymankiewicz
mesh_terms: D000751:Anemia, Neonatal / Q000453:epidemiology / Q000209:etiology; D001034:Apgar Score; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology* / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000209:etiology*; D007752:Obstetric Labor, Premature / Q000453:epidemiology* / Q000209:etiology*; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology / Q000209:etiology