Does proteolysis explain glutamine release from the septic brain?
Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen.
Dejong
Cornelius H C
CH
Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University and University Hospital Maastricht, 6202 AZ Maastricht, the Netherlands. chc.dejong@ah.unimaas.nl
Olde Damink
Steven W M
SW
D000597:Amino Acids, Branched-Chain / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D005973:Glutamine / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism / Q000494:pharmacology*; D018805:Sepsis / Q000503:physiopathology*
D000597:Amino Acids, Branched-Chain; D008070:Lipopolysaccharides; D005973:Glutamine; D010447:Peptide Hydrolases