title: Potentiation of antibiotic activity by Eugenia uniflora and Eugenia jambolanum.
abstract: This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested was not inhibited in a clinically relevant form by the extract. The minimal inhibitory concentration was >or=1,024 microg/mL for both strains of E. coli assayed. Synergism between this extract and gentamicin was demonstrated. In the same extract synergism was observed between chlorpromazine and kanamycin and between amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. It is therefore suggested that extracts from E. uniflora L. and E. jambolanum L. could be used as a source of plant-derived natural products with modifying antibiotic activity to gentamicin.
authors.affiliation: Laboratory of Research in Natural Products, Center of Biological Sciences and Health, University of the Region of Cariri, Crato, Brazil. sychoi@kfri.re.kr
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
authors.forename: José G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Vivyanne S
authors.initials: VS
authors.lastname: Falcão-Silva
authors.forename: José P
authors.initials: JP
authors.lastname: Siqueira-Júnior
authors.forename: Edeltrudes O
authors.initials: EO
authors.lastname: Lima
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D027842:Syzygium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts