New potential uses for cardiac troponins.
This review briefly synthesizes the molecular biology of troponin, which is currently the best biochemical marker for the detection of cardiac injury and, thus, acute myocardial infarction as well. Potential new uses for the marker based on these insights, with a specific interest in cardiac troponin fragments that potentially could be linked to distinct clinical conditions, are described. Some of the clinical problems clinicians are faced with including how to use the markers in renal failure and the difficulties associated with the heterogeneity of current troponin assays are also discussed. Finally, we present the possibility of specific cardiac troponin fragments resulting from modification or degradation, associated with distinct pathological processes, as new potential uses for this biomarker.
Vasile
Vlad C
VC
Mayo Clinic & Mayo Medical School, Department of Internal Medicine, Division of Cardiovascular Diseases & Department of Laboratory Medicine & Pathology, Rochester, Minnesota, USA.
Jaffe
Allan S
AS