title: Association of anthropometric characteristics with the risk of malignant lymphoma and plasma cell myeloma in a Japanese population: a population-based cohort study.
abstract: BACKGROUND
  Although Asian and Western populations differ markedly in anthropometric characteristics and the incidence of malignant lymphoma and plasma cell myeloma, few studies have evaluated the associations between these variables among Asian populations.
  
  
  METHODS
  We conducted a large-scale, population-based prospective study in a Japanese cohort that included 45,007 men and 49,540 women ages 40 to 69 years at baseline. During an average follow-up period of 13 years, 257 cases of malignant lymphoma and 88 of plasma cell myeloma were identified. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated with the use of a Cox regression model adjusted for potential confounders.
  
  
  RESULTS
  Compared with the 1st quartile, categorization in the 4th quartile for height showed a positive association with lymphoid neoplasm risk (HR, 1.38; 95% CI, 1.00-1.91), and the association was significant among men (HR, 1.72; 95% CI, 1.11-2.66). A similar trend was observed for subcategories of malignant lymphoma, plasma cell myeloma, and non-Hodgkin lymphoma, albeit the associations were weak due to the small number of subjects in each category. In contrast, weight and body mass index were not associated with risk of lymphoid neoplasm.
  
  
  CONCLUSIONS
  Height was positively associated with risk of lymphoid neoplasm in a Japanese population.
  
  
  CONCLUSIONS
  Our data suggested that early life exposure to growth-related hormones, such as insulin-like growth factors and growth hormones, or genetic factors relating to height may affect the risk of lymphoid neoplasm.
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Kanda
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Manami
authors.initials: M
authors.lastname: Inoue
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Norie
authors.initials: N
authors.lastname: Sawada
authors.forename: Taichi
authors.initials: T
authors.lastname: Shimazu
authors.forename: Taiki
authors.initials: T
authors.lastname: Yamaji
authors.forename: Shizuka
authors.initials: S
authors.lastname: Sasazuki
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001827:Body Height; D049628:Body Size; D001835:Body Weight; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008223:Lymphoma / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology* / Q000209:etiology; D011446:Prospective Studies; D013002:Somatomedins
chemical_list: D013002:Somatomedins