Evaluation of the Nano Spray Dryer B-90 for pharmaceutical applications.
The vibrating mesh spray technology implemented in the Nano Spray Dryer B-90 was evaluated for pharmaceutical applications by spray drying common pharmaceutical excipients (e.g. trehalose, mannitol) and model drugs (e.g. griseofulvin). Aerosol droplet size measurements investigated the influence of spray solution factors (e.g. viscosity, surface tension) and of vibrating mesh aperture sizes on particle characteristics. Particle deposition on the spray nozzle was addressed by analyzing the influence of spray solute concentration and solvent on the process outcome. Submicron particles with 0.5 ?m and 0.8 ?m mean particle size were obtained at high yields for 50?mg powder amounts.
Schmid
Katja
K
Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilian-University Munich, Germany.
Arpagaus
Cordin
C
Friess
Wolfgang
W
D000336:Aerosols; D004867:Equipment Design; D005079:Excipients / Q000737:chemistry*; D006118:Griseofulvin; D008353:Mannitol; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000648:ultrastructure*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011208:Powders; D013499:Surface Properties; D013500:Surface Tension; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods; D014199:Trehalose
D000336:Aerosols; D005079:Excipients; D004364:Pharmaceutical Preparations; D011208:Powders; D006118:Griseofulvin; D008353:Mannitol; D014199:Trehalose