title: [Effect of continuous passive motion on basic fibroblast growth factor expression during tendon-bone repair after surgical repair of acute rupture of the supraspinatus tendon in rabbits].
abstract: OBJECTIVE
  To study the effect of continuous passive motion (CPM) on basic fibroblast growth factor (b-FGF) expression during tendon-bone repair in rabbits and explore the role of stress in the postoperative repair after acute rotator cuff injury.
  
  
  METHODS
  Sixteen rabbits randomized into CPM group (n=8) and non-CPM group (n=8) were subjected to surgically induced acute rupture of the supraspinatus tendon and subsequent surgical repair, with another two rabbits serving as the control. Two weeks after the operation, the rabbits in CPM group underwent CPM training, and those in non-CPM group were normally fed only. At 2, 4, 6, and 8 weeks after the operation, 2 rabbits from each group were sacrificed and the tissue samples were obtained for detecting the changes in b-FGF expression.
  
  
  RESULTS
  Two weeks after the operation, b-FGF expression was detected in both groups, and the CPM group showed slightly higher and more diffusive expression. At 4 weeks, b-FGF expression was significantly higher and distributed over a greater area in CPM group and in the non-CPM group. A large number of fibroblasts positive for b-FGF expression were identified in CPM group, aligning in parallel with the tendon membrane. At 6 weeks, b-FGF in the CPM group showed no obvious changes but that in the non-CPM group became lightened. At 8 weeks, b-FGF expression was reduced in both groups, which was more obvious in the non-CPM group.
  
  
  CONCLUSIONS
  CPM can promote b-FGF expression to enhance type III collagen synthesis at the tendon-bone interface in early stage of tendon-bone repair following acute rupture of supraspinatus tendon in rabbits, thereby contributing to tendon-bone recovery after rotator cuff injury.
authors.affiliation: Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. jht187@163.com
authors.forename: Sen
authors.initials: S
authors.lastname: Li
authors.forename: Shao-xiong
authors.initials: SX
authors.lastname: Min
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Guo-jian
authors.initials: GJ
authors.lastname: Fu
authors.forename: Peng-cheng
authors.initials: PC
authors.lastname: Wang
authors.forename: An-min
authors.initials: AM
authors.lastname: Jin
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects* / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D008297:Male; D011184:Postoperative Period; D011817:Rabbits; D011897:Random Allocation; D016059:Range of Motion, Articular; D012421:Rupture / Q000601:surgery; D013708:Tendon Injuries / Q000534:rehabilitation* / Q000601:surgery*; D013710:Tendons / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
chemical_list: D016222:Fibroblast Growth Factor 2