p63 and p73, the ancestors of p53.
p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the high degree of structural similarity shared by the p53 family members, p73 and p63 can bind and activate transcription from the majority of the p53-responsive promoters. Besides overlapping functions shared with p53 (i.e., induction of apoptosis in response to cellular stress), the existence of extensive structural variability within the family determines unique roles for p63 and p73. Their crucial and specific functions in controlling development and differentiation are well exemplified by the p63 and p73 knockout mouse phenotypes. Here, we describe the contribution of p63 and p73 to human pathology with emphasis on their roles in tumorigenesis and development.
Dötsch
V
V
Institute of Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany.
Bernassola
F
F
Coutandin
D
D
Candi
E
E
Melino
G
G
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D020033:Protein Isoforms; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D020033:Protein Isoforms; C115051:TP63 protein, human; C000606460:TP73 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins