[A case of drug-induced interstitial pneumonitis after adjuvant chemotherapy with gemcitabine for bile duct cancer].
A 70-year-old man received pancreaticoduodenectomy for bile duct cancer and had been administered gemcitabine for 1 year as adjuvant chemotherapy. He complained of shortness of breath on effort and was admitted for gemcitabine-induced interstitial pneumonitis. His respiratory status was worsening after admission, so he was transferred in the intensive-care unit and required mechanical ventilator and steroid pulse therapy with 1,000 mg/day of methylprednisolone. His symptoms and radiological findings were dramatically improved. The patient could be discharged on the 24th day after admission. Interstitial pneumonitis induced by gemcitabine is rare, but could lead to severe complications, which could develop after long-term administration and should be treated by corticosteroid as soon as possible.
Mori
Ryutaro
R
Dept. of Surgery, Fujisawa Municipal Hospital.
Misuta
Koichiro
K
Sasaki
Mari
M
Murakami
Takashi
T
Tokuhisa
Motohiko
M
Hasegawa
Seiji
S
Eguchi
Kazuya
K
Nakano
Akira
A
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D008775:Methylprednisolone; D000093542:Gemcitabine