Assembly of viral capsids, buckling, and the Asaro-Grinfeld-Tiller instability.
Icosahedral viral shells are characterized by intrinsic elastic stress focused on the 12 structurally required pentamers. We show that, according to thin-shell theory, assembling icosahedral viral shells should be subject to the Asaro-Grinfeld-Tiller instability (AGTI). AGTIs are encountered in growing epitaxial films exposed to extrinsic elastic stress. For viral shells, the AGTI relieves intrinsic elastic stresses by generating corrugation along the perimeter of the assembling shell. The buckling transition of Lidmar, Mirny, and Nelson provides an alternative mechanism for stress release, which in principle would allow for avoidance of AGTIs. For system parameters appropriate for viral shells however, the AGTI appears to be unavoidable. The azimuthal stress condensation produced by the AGTI might actually assist assembly by providing a guiding mechanism for the insertion of pentamers during viral assembly.
Morozov
Alexander Yu
AY
Department of Physics and Astronomy, University of California-Los Angeles, Los Angeles, California 90024, USA.
Bruinsma
Robijn F
RF
D001696:Biomechanical Phenomena; D002213:Capsid / Q000737:chemistry* / Q000378:metabolism*; D004548:Elasticity; D007700:Kinetics; D008954:Models, Biological; D011485:Protein Binding; D013314:Stress, Mechanical; D013816:Thermodynamics; D014780:Viruses / Q000737:chemistry*