title: Failure of vancomycin treatment for meningitis caused by vancomycin-susceptible Enterococcus faecium.
abstract: This case report describes a nosocomial vancomycin-sensitive Enterococcus faecium meningitis with poor response to vancomycin. E. faecium infections continue to represent a therapeutic challenge in Europe, even in countries where vancomycin resistance is still rare. In the case of vancomycin-sensitive E. faecium meningitis, intravenous chloramphenicol should be considered as a treatment option.
authors.affiliation: Department of Neurology, Orbis Medical Centre, Sittard, The Netherlands. ellenvanoverbeek@gmail.com
authors.forename: Ellen C
authors.initials: EC
authors.lastname: van Overbeek
authors.forename: Rob
authors.initials: R
authors.lastname: Janknegt
authors.forename: Hans W M
authors.initials: HW
authors.lastname: Ter Berg
authors.forename: Janetta
authors.initials: J
authors.lastname: Top
authors.forename: Esther
authors.initials: E
authors.lastname: Sportel
authors.forename: Edou R
authors.initials: ER
authors.lastname: Heddema
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017211:Treatment Failure; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D014640:Vancomycin