title: Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits.
abstract: Tilmicosin (TIM, Pulmotil) was administered to eight rabbits by oral gavage at a dose of 12.5 mg/kg body weight for 2, 5, and 7 days, and its plasma kinetics and intrapulmonary disposition were investigated. TIM concentrations in plasma samples collected after days 1 and 6 of treatment were measured by high-performance liquid chromatography with ultraviolet detection. The pharmacokinetic parameters, obtained by non-compartmental analysis of TIM plasma concentrations, did not show any significant variations between days 1 and 6. From the second day of treatment, TIM concentrations attained in lung tissue and pulmonary alveolar macrophages (PAM) exceeded those in plasma by 7- and 400-fold, respectively, and high levels were maintained in lung tissues during the entire treatment duration. After the first day of withdrawal, a fast decline in TIM levels in both plasma and lung tissue was observed, but in PAM, much higher concentrations were maintained after 3 days of TIM withdrawal.
authors.affiliation: Dipartimento di Sanità Pubblica, Patologia Comparata ed Igiene Veterinaria, Legnaro, PD, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gallina
authors.forename: L
authors.initials: L
authors.lastname: Lucatello
authors.forename: I
authors.initials: I
authors.lastname: Drigo
authors.forename: M
authors.initials: M
authors.lastname: Cocchi
authors.forename: S
authors.initials: S
authors.lastname: Scandurra
authors.forename: F
authors.initials: F
authors.lastname: Agnoletti
authors.forename: C
authors.initials: C
authors.lastname: Montesissa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D019540:Area Under Curve; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D008168:Lung / Q000378:metabolism*; D011817:Rabbits; D014018:Tissue Distribution; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; C052319:tilmicosin; D015645:Tylosin