title: Infliximab in a patient with refractory necrotizing scleritis associated with relapsing polychondritis.
abstract: OBJECTIVE
  To describe a case of necrotizing scleritis associated with relapsing polychondritis (RP), which was treated with infliximab.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 60-year-old woman presented with a red eye. She had a past medical history of nose deformity, hearing problem, and tinnitus. Ophthalmological examination disclosed necrotizing scleritis and peripheral ulcerative keratitis. RP was diagnosed. The disease progressed despite treatment with methotrexate and cyclophosphamide, but infliximab resulted in a stabilization of the disease.
  
  
  CONCLUSIONS
  Infliximab could be a new weapon to treat refractory scleritis due to RP.
authors.affiliation: Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Jabbarvand
authors.forename: Masoud Aghsaei
authors.initials: MA
authors.lastname: Fard
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D011081:Polychondritis, Relapsing / Q000150:complications*; D012074:Remission Induction / Q000379:methods; D015423:Scleritis / Q000188:drug therapy* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab