Strategies for preventing occupational exposure to potent compounds.
Occupational exposure to active pharmaceutical ingredients in a manufacturing or laboratory environmental can cause unintended health effects in workers handling these compounds. Occupational health professionals in the pharmaceutical industry have responded to this hazard recognition by employing strategies for the risk evaluation and management of potent APIs, otherwise known by the term 'potent compounds'. The purpose of this paper is to provide an overview of the necessary strategy components for preventing occupational exposure to potent compounds.
Calhoun
Dean M
DM
Affygility Solutions, LLC, Broomfield, Colorado, USA. dcalhoun@affygility.com
Coler
Angela B
AB
Nieusma
Joe L
JL
D000818:Animals; D004345:Drug Industry; D064420:Drug-Related Side Effects and Adverse Reactions; D004784:Environmental Monitoring; D006801:Humans; D019055:No-Observed-Adverse-Effect Level; D009784:Occupational Diseases / Q000139:chemically induced / Q000517:prevention & control*; D016273:Occupational Exposure / Q000009:adverse effects / Q000517:prevention & control*; D016272:Occupational Health; D018570:Risk Assessment; D013045:Species Specificity