Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a tumor cell line.
Functionalization of gold nanoparticles (AuNPs) with both a targeting peptide (an analogue of the peptide Bombesin) and a drug peptide ligand (an analogue of the RAF peptide) with the aim of improving selectivity in the delivery of the conjugates as well as the antitumor activity is described. Studies on the internalization mechanism of peptide-AuNP conjugates and viability of cells were carried out. An enhancement of the activity and selectivity of the peptide multifunctionalized conjugates was observed.
Hosta-Rigau
Leticia
L
CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Institute for Research in Biomedicine, Barcelona, Spain.
Olmedo
Ivonne
I
Arbiol
Jordi
J
Cruz
Luis J
LJ
Kogan
Marcelo J
MJ
Albericio
Fernando
F
D000595:Amino Acid Sequence; D001839:Bombesin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D005456:Fluorescent Dyes / Q000032:analysis; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D008969:Molecular Sequence Data; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D018004:Receptors, Bombesin / Q000737:chemistry / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D046590:Spectroscopy, Electron Energy-Loss
D005456:Fluorescent Dyes; D008024:Ligands; D018377:Neurotransmitter Agents; D010455:Peptides; D018004:Receptors, Bombesin; D006046:Gold; D001839:Bombesin