A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation.
Obianyo
Obiamaka
O
Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.
Causey
Corey P
CP
Osborne
Tanesha C
TC
Jones
Justin E
JE
Lee
Young-Ho
YH
Stallcup
Michael R
MR
Thompson
Paul R
PR
D000578:Amidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001120:Arginine / Q000378:metabolism*; D020134:Catalytic Domain; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008745:Methylation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011484:Protein-Arginine N-Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000578:Amidines; D004791:Enzyme Inhibitors; D010455:Peptides; D001120:Arginine; D011484:Protein-Arginine N-Methyltransferases