[Sleep-disordered breathing in long-term opioid therapy].
Chronic opioid use has been known to cause disturbed sleep as well as excessive daytime sleepiness. During induction and maintenance of opioid use there is a reduction of REM- and slow wave sleep. Central sleep apnea (CSA) has been reported in about 30 % of patients with chronic opioid use. Ataxic breathing and CSA are more prominent in NREM- than REM-sleep. CSA does not seem the sole cause of excessive daytime sleepiness in these patients. Further studies are necessary regarding the effects and consequences of chronic opioid use during sleep.
Koehler
U
U
Klinik für Innere Medizin, Schwerpunkt Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universität Marburg. koehleru@staff.uni-marburg.de
Augsten
M
M
Cassel
W
W
Jerrentrup
A
A
Nolte
J
J
Dette
F
F
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D002940:Circadian Rhythm / Q000187:drug effects; D045422:Continuous Positive Airway Pressure; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D008134:Long-Term Care; D010146:Pain / Q000188:drug therapy*; D017286:Polysomnography; D020182:Sleep Apnea, Central / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D000701:Analgesics, Opioid