Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt.
An unprecedented enantioselective Michael addition of various ketones to maleimides catalyzed by a simple bifunctional primary amine, monosulfonyl DPEN salt, is reported and provides the desired adducts in good to excellent yields (up to 99%) with excellent enantioselectivities (up to 99%).
Yu
Feng
F
Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Sun
Xiaomin
X
Jin
Zhichao
Z
Wen
Shigang
S
Liang
Xinmiao
X
Ye
Jinxing
J
D002384:Catalysis; D005029:Ethylenediamines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
D005029:Ethylenediamines; D007659:Ketones; D008301:Maleimides; D012492:Salts; C007305:1,2-dianilinoethane