title: First detection of CTX-M and SHV extended-spectrum beta-lactamases in Escherichia coli urinary tract isolates from dogs and cats in the United States.
abstract: One hundred fifty canine and feline Escherichia coli isolates associated with urinary tract infections were screened for the presence of extended-spectrum beta-lactamase (ESBL) genes. Out of 60 isolates suspected to be ESBL positive based on antimicrobial susceptibility testing, 11 ESBLs were identified, including one SHV-12 gene, one CTX-M-14 gene, and nine CTX-M-15 genes. This study provides the first report of CTX-M- and SHV-type ESBLs in dogs and cats in the United States.
authors.affiliation: Matthew J. Ryan Veterinary Hospital, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104-6010, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: O'Keefe
authors.forename: Tabitha A
authors.initials: TA
authors.lastname: Hutton
authors.forename: Dieter M
authors.initials: DM
authors.lastname: Schifferli
authors.forename: Shelley C
authors.initials: SC
authors.lastname: Rankin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002371:Cat Diseases / Q000382:microbiology*; D002415:Cats; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014481:United States; D014552:Urinary Tract Infections / Q000382:microbiology / Q000662:veterinary*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; C456080:beta-lactamase CTX-M-14; C473109:beta-lactamase CTX-M-15; C107198:beta-lactamase SHV-12; D001618:beta-Lactamases