Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.
Mutations of the ten eleven translocation 2 gene (TET2) have recently been reported in myelodysplastic syndrome and myeloproliferative neoplasms. We analyzed the incidence and prognostic value of TET2 point mutations and other genomic alterations by direct sequencing and single nucleotide polymorphism microarray analysis in 111 de novo acute myeloid leukemia, who had all achieved complete remission (CR). Mutations were observed in 19 (17%) of the 111 patients compared with 10 (27%) of 36 patients who had failed to achieve CR (P = .2). In the 111 patients who had achieved CR, TET2 alterations were only significantly associated with NPM1 mutations but not with other pretreatment characteristics. TET2 gene status was not significantly correlated with disease-free survival and overall survival, both in the entire cohort and in patients with normal karyotype.
Nibourel
Olivier
O
Laboratoire d'hématologie, Centre Hospitalier Regional Universitaire de Lille, Boulevard du Professeur Leclercq, Lille Cedex, France.
Kosmider
Olivier
O
Cheok
Meyling
M
Boissel
Nicolas
N
Renneville
Aline
A
Philippe
Nathalie
N
Dombret
Hervé
H
Dreyfus
François
F
Quesnel
Bruno
B
Geffroy
Sandrine
S
Quentin
Samuel
S
Roche-Lestienne
Catherine
C
Cayuela
Jean-Michel
JM
Roumier
Christophe
C
Fenaux
Pierre
P
Vainchenker
William
W
Bernard
Olivier A
OA
Soulier
Jean
J
Fontenay
Michaëla
M
Preudhomme
Claude
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics*; D049308:Dioxygenases; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D000090243:Nucleophosmin; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012074:Remission Induction; D015996:Survival Rate; D014178:Translocation, Genetic / Q000235:genetics*; D055815:Young Adult
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C000716967:NPM1 protein, human; D011518:Proto-Oncogene Proteins; D000090243:Nucleophosmin; D049308:Dioxygenases; C541081:TET2 protein, human