title: Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population.
abstract: GSTM1 and GSTT1 polymorphisms have been proposed in relationship with chronic obstructive pulmonary disease (COPD). We investigated the association between these polymorphisms and COPD (as well as its subtypes emphysema and chronic bronchitis) in 234 COPD patients and 182 healthy controls in the Tunisian population. Genotyping was performed using multiplex PCR. GSTM1-null genotype frequency was significantly higher in COPD patients than in controls (P = 0.02); however, multivariate analysis of cofounding variables showed no independent association with this genotype (P = 0.073). In contrast, the association of the GSTM1-null genotype with emphysema was significant, even after adjustment for risk factors (P = 0.011). There were no significant differences in GSTT1 genotypes between patients and controls. The GSTM1 null allele is likely not an independent risk factor for COPD but is related to emphysema, whereas the GSTT1 gene is not associated with the disease.
authors.affiliation: Monastir University, Tunisia. lakhdarramzi@yahoo.fr
authors.forename: Ramzi
authors.initials: R
authors.lastname: Lakhdar
authors.forename: Sabri
authors.initials: S
authors.lastname: Denden
authors.forename: Jalel
authors.initials: J
authors.lastname: Knani
authors.forename: Nadia
authors.initials: N
authors.lastname: Leban
authors.forename: Houria
authors.initials: H
authors.lastname: Daimi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Hassine
authors.forename: Gérard
authors.initials: G
authors.lastname: Lefranc
authors.forename: Jemni
authors.initials: J
authors.lastname: Ben Chibani
authors.forename: Amel
authors.initials: A
authors.lastname: Haj Khelil
mesh_terms: D016022:Case-Control Studies; D003710:Demography; D004646:Emphysema / Q000150:complications / Q000201:enzymology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D014416:Tunisia
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1