title: Both calcitonin and calcitonin gene-related peptides' thresholds of hypophagia are considerably lower in chicks selected for high rather than low juvenile body weight.
abstract: Effects of intracerebroventricular (ICV) injection of calcitonin (CT) and calcitonin gene-related peptide (CGRP) on food and water intake were measured in two lines of White Plymouth Rock chickens from a common base population that have undergone long-term divergent selection for either low (LWS) or high (HWS) juvenile body weight. These lines contain anorexic and obese individuals and serve as models for hypo- and hyperphagia. For both ICV injection of CT and CGRP, line HWS responded to a lower dose with decreased food intake than did line LWS. Both peptides were also associated with reduced water intake in both lines. Although plasma glucose concentrations were inherently different between lines, neither CT nor CGRP affected these levels. Comprehensive behavior analyses were conducted and only the number of food pecks was differentially suppressed between lines after both CT and CGRP injection. Thus, the selection program may have caused alterations in the endogenous CT and CGRP systems that synergistically, with other neurotransmitter systems, contribute to the role of food intake on the differential body weights between these lines.
authors.affiliation: Department of Biology, Radford University, Radford, Virginia, United States. mcline@radford.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Cline
authors.forename: Ryan
authors.initials: R
authors.lastname: Siders
authors.forename: Brandon A
authors.initials: BA
authors.lastname: Newmyer
authors.forename: Marissa L
authors.initials: ML
authors.lastname: Smith
authors.forename: Paul B
authors.initials: PB
authors.lastname: Siegel
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects* / Q000235:genetics; D002116:Calcitonin / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects* / Q000235:genetics; D004357:Drug Synergism; D004435:Eating / Q000187:drug effects* / Q000235:genetics; D004924:Escape Reaction / Q000187:drug effects; D007276:Injections, Intraventricular / Q000379:methods; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide