Vascular endothelial growth factor genetic polymorphisms and haplotypes in women with migraine.
Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154)A, and G(-634)C) and VEGF haplotypes are associated with migraine. We studied 114 healthy women without migraine and 175 women with migraine (129 without aura, and 46 with aura). We found no differences in the distributions of VEGF genotypes and alleles (p > 0.05). However, the CAC haplotype was more frequent in controls than in migraine patients, and the AGC haplotype was more frequent in patients with migraine with aura than in controls (both p < 0.05). These findings suggest that VEGF haplotypes affect susceptibility to migraine.
Gonçalves
Flavia M
FM
Department of Pharmacology, State University of Campinas, Sao Paulo, Brazil.
Martins-Oliveira
Alisson
A
Speciali
Jose G
JG
Izidoro-Toledo
Tatiane C
TC
Luizon
Marcelo R
MR
Dach
Fabiola
F
Tanus-Santos
Jose E
JE
D000483:Alleles; D005260:Female; D015316:Genetic Therapy; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008881:Migraine Disorders / Q000235:genetics; D011110:Polymorphism, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D042442:Vascular Endothelial Growth Factors / Q000235:genetics
D036341:Intercellular Signaling Peptides and Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors