title: [Study on application of CPP-ACP on tooth mineralization during orthodontic treatment with fixed appliance].
abstract: OBJECTIVE
  To determine the value of clinical application of CPP-ACP during orthodontic treatment with fixed appliance.
  
  
  METHODS
  Seventy-five subjects were divided randomly into three groups, the control group, experimental group A and experimental group B. The control group were emphasized on daily oral hygiene. Experimental group A used fluor protector every three months under the dentist's guidance. Experimental group B used Casein phosphopeptide amorphous calcium phosphate(CCP-ACP) once a day. After finishing the orthodontic treatment, photos were taken under the same condition ,then the degree of the enamel's demineralization was examined and the enamel decalcification index(EDI) was calculated. SPSS11.0 software package was used for statistical analysis.
  
  
  RESULTS
  (1)The incidence of three groups' enamel decalcification declined in sequence as the control group(60%),experimental group A (36%), experimental group B (32%).(2)The incidence of the teeth's enamel calcification of three groups declined in sequence as the control group(14.7%),experimental group A (8.46%), experimental group B (7.72%), the difference between the control group and two experimental groups was significant, while no significant difference was found between the two experimental groups.(3(EDI of the control group was 0.155+/-0.023, EDI of the experimental group A was 0.082+/-0.009,while EDI of the experimental group B was 0.078+/-0.006. The difference between the control group and two experimental groups was statistically significant, while was not statistically significant between the two experimental groups.
  
  
  CONCLUSIONS
  The application of fluor protector and CPP-ACP can improve the mineralization of the teeth during orthodontic treatment with fixed appliance. CPP-ACP is more convenient for the patients to use. Supported by Research Fund of Bureau of Science and Technology of Futian District Shenzhen City(Grant No.FTWS056).
authors.affiliation: Department of Stomatology, the Fourth People's Hospital of Shenzhen, Shenzhen 518033, Guangdong Province, China. hewendan@yahoo.com.cn
authors.forename: Wen-dan
authors.initials: WD
authors.lastname: He
authors.forename: Ying-zhi
authors.initials: YZ
authors.lastname: Liu
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Xu
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
mesh_terms: D002364:Caseins; D003743:Dental Enamel; D004338:Drug Combinations; D005460:Fluorides, Topical; D006801:Humans; D009967:Orthodontic Appliances; D011140:Polyurethanes; D012821:Silanes
chemical_list: D002364:Caseins; D004338:Drug Combinations; D005460:Fluorides, Topical; D011140:Polyurethanes; D012821:Silanes; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; C022599:Fluor Protector