title: Difference of Helicobacter pylori colonization in recurrent inflammatory and simple hyperplastic tonsil tissues.
abstract: OBJECTIVE
  To investigate the difference in colonization by Helicobacter pylori between recurrent inflammatory and normal hyperplastic human palatine tonsil tissues.
  
  
  METHODS
  A retrospective review of a prospective data set.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Patients undergoing tonsillectomy for a variety of reasons had routine screening for H pylori. Medical records of all patients who underwent tonsillectomy were reviewed to identify (1) indications for surgery and (2) presence or absence of H pylori in the specimen. All medical records that had information on H pylori were included. Patients were divided into the following 2 groups: those having tonsillectomy for chronic recurrent tonsillitis and those having tonsillectomy for sleep-related breathing disorders (SRBDs) with no recent history of tonsillitis.
  
  
  RESULTS
  There were 44 patients in the tonsillitis group (18 women and 26 men; mean age, 28.6 years) and 50 patients in the SRBD group (11 women and 39 men; mean age, 33.6 years). Of 94 patients the Pronto Dry test results were positive in 33 (35%) and negative in 61 (65%). The H pylori positive rates in the tonsillitis and SRBD groups were 48% (21 of 44) and 24% (12 of 50), respectively (P < .001).
  
  
  CONCLUSIONS
  Helicobacter pylori can colonize in human palatine tonsil tissues. A significantly higher positive H pylori rate was present in the tonsillitis group (48%) compared with the SRBD group (24%). Based on this finding, future studies should be performed to elucidate whether eradication therapy for H pylori is effective in decreasing recurrent inflammation of human palatine tonsils.
authors.affiliation: Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Hsin-Ching
authors.initials: HC
authors.lastname: Lin
authors.forename: Pei-Yin
authors.initials: PY
authors.lastname: Wu
authors.forename: Michael
authors.initials: M
authors.lastname: Friedman
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Meghan
authors.initials: M
authors.lastname: Wilson
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D014068:Tonsillectomy; D014069:Tonsillitis / Q000382:microbiology* / Q000601:surgery