title: [Experimental models in epilepsy].
abstract: BACKGROUND
  epilepsy is one of the neurological pathologies with the highest rate of incidence and with a significant number of negatives consequences. Current pharmacological treatments have an antiepileptic effect, allowing control over 70% of the patients, but they are not able to prevent the development of epileptogenesis from occurring.
  
  
  METHODS
  ee have reviewed the most relevant publications of experimental animal models with epilepsy by using the PubMed data base.
  
  
  RESULTS
  we found a large number of publications related to different kinds of experimental models, both genetic (transgenic, genetically determined) and lesional which appeared to resemble the different types of human epilepsy.
  
  
  CONCLUSIONS
  even though many important improvements have been accomplished in the area of epilepsy in the last decades, there are still many aspects to be clarified. In this regard, experimental models might become a very useful means for a better understanding of pathophysiological mechanisms and in the search for more efficient treatments.
authors.affiliation: Instituto de Neurociencias, Servicio de Neurología, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, España.
authors.forename: M E
authors.initials: ME
authors.lastname: Garcia Garcia
authors.forename: I
authors.initials: I
authors.lastname: Garcia Morales
authors.forename: J
authors.initials: J
authors.lastname: Matías Guiu
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D039781:PubMed
chemical_list: D000927:Anticonvulsants