title: Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.
abstract: Brain-derived neurotrophic factor (BDNF) plays an important role in hippocampal synaptic plasticity and long-term potentiation. A valine (Val) to methionine (Met) substitution in the BDNF gene (Val66Met) has been associated with episodic memory performance. This study aimed at fine-mapping the genomic region harbouring BDNF and the adjacent gene, BDNFOS, in order to identify other possible memory-related gene variants. Healthy young Swiss adults (n=333) underwent a verbal memory free-recall task which used words with both neutral and emotional content. Genetic variability of the BDNF and BDNFOS region was covered by analysing 55 single nucleotide polymorphisms (SNPs). Among all examined SNPs, the non-synonymous Val66Met SNP rs6265 showed the highest significant level of association with memory performance for words with emotional content. Recall performance for neutral words was unrelated to the analysed SNPs. Our results support a role for the Val66Met BDNF polymorphism in episodic memory and suggest a modulatory influence of emotional valence.
authors.affiliation: University of Basel, Department of Psychology, Division of Molecular Psychology, Basel, Switzerland. flurin.cathomas@stud.unibas.ch
authors.forename: Flurin
authors.initials: F
authors.lastname: Cathomas
authors.forename: Christian
authors.initials: C
authors.lastname: Vogler
authors.forename: Jessica C
authors.initials: JC
authors.lastname: Euler-Sigmund
authors.forename: Dominique J-F
authors.initials: DJ
authors.lastname: de Quervain
authors.forename: Andreas
authors.initials: A
authors.lastname: Papassotiropoulos
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D004644:Emotions / Q000502:physiology; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008297:Male; D061212:Memory, Episodic / Q000502:physiology*; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014633:Valine / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine