[Reaction of Leishmania (Leishmania) mexicana antigens by sera of patients with cutaneous leishmaniasis from Sinaloa, Mexico].
OBJECTIVE
To detect Leishmania mexicana antigens reacting with sera of patients with cutaneous leishmaniasis (CL).


METHODS
A crude extract of L. mexicana was used as antigen for 2-D Western blot using sera from 5 patients with CL and controls from Sinaloa, Mexico during 2008.


RESULTS
Five antigens were detected in the five infected patients analyzed; their molecular weights and isoelectric points were: 26 kDa (pI 7.8), 27 kDa (pI 8.1), 28 kDa (pI 8.6), 29 kDa (pI 8.5) and 31 kDa (pI 9.0).


CONCLUSIONS
New potentially immunodominant L. mexicana antigens were detected, suggesting that this parasite could be the species responsible for human infection in Sinaloa.
Salazar-Mejía
Patricia Guadalupe
PG
Laboratorio de Biomedicina, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Sinaloa, México.
Tejeda-Aguirre
Celia Rosa
CR
López-Moreno
Héctor Samuel
HS
D000953:Antigens, Protozoan / Q000097:blood*; D006801:Humans; D007894:Leishmania mexicana / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000097:blood* / Q000276:immunology*; D008800:Mexico
D000953:Antigens, Protozoan