title: Mitochondrial biology in Alzheimer's disease pathogenesis.
abstract: Despite the increasing knowledge of Alzheimer's disease (AD) management with novel pharmacologic agents, most of them are only transiently fixing symptomatic pathology. Currently there is rapid growth in the field of neuroprotective pharmacology and increasing focus on the involvement of mitochondria in this devastating disease. This review is directed at understanding the role of mitochondria-mediated pathways in AD and integrating basic biology of the mitochondria with knowledge of possible pharmacologic targets for AD treatment in an attempt to elucidate novel mitochondria-driven therapeutic interventions useful to both clinical and basic research.
authors.affiliation: Unidad de Neuropsicofarmacología Translacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: María F
authors.initials: MF
authors.lastname: Galindo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ikuta
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Gemma
authors.initials: G
authors.lastname: Casadesus
authors.forename: Joaquín
authors.initials: J
authors.lastname: Jordán
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000009:adverse effects / Q000502:physiology; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D028361:Mitochondrial Diseases / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides