title: Using glycosylated hemoglobin to define the metabolic syndrome in United States adults.
abstract: OBJECTIVE
  To compare the use of GHb and fasting plasma glucose (FPG) to define the metabolic syndrome (MetS).
  
  
  METHODS
  Data from the U.S. National Health and Nutrition Examination Survey 1999-2006 were used. MetS was defined using the consensus criteria in 2009. Raised blood glucose was defined as either FPG >or=100 mg/dl (5.6 mmol/l) or GHb >or=5.7%.
  
  
  RESULTS
  In 2003-2006, there was 91.3% agreement between GHb and FPG when either was used to define MetS. The agreement was good irrespective of age, sex, race/ethnicity, BMI, and diabetes status (>or=87.4%). Similar results were found in 1999-2002. Among subjects without diabetes, only the use of GHb alone, but not FPG, resulted in significant association with cardiovascular diseases (odds ratio 1.45, P = 0.005).
  
  
  CONCLUSIONS
  Using GHb instead of FPG to define MetS is feasible. It also identifies individuals with increased cardiovascular risk.
authors.affiliation: Department of Medicine, University of Hong Kong, Hong Kong, China.
authors.forename: Kwok Leung
authors.initials: KL
authors.lastname: Ong
authors.forename: Annette W K
authors.initials: AW
authors.lastname: Tso
authors.forename: Karen S L
authors.initials: KS
authors.lastname: Lam
authors.forename: Stacey S
authors.initials: SS
authors.lastname: Cherny
authors.forename: Pak Chung
authors.initials: PC
authors.lastname: Sham
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism*; D008875:Middle Aged; D014481:United States; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin