Correlation of treatment time and ultrafiltration rate with serum albumin and C-reactive protein levels in patients with end-stage kidney disease receiving chronic maintenance hemodialysis: a cross-sectional study.
BACKGROUND
The relationship between treatment time, ultrafiltration rate (UFR) and inflammation has received limited exploration so far.


METHODS
This is a cross-sectional cohort study of 12 hemodialysis clinics. Statistical models explored the association of multiple patient- and dialysis-specific covariates with low albumin (<or=40 g/l) or high C-reactive protein (CRP) (>5 mg/dl) and calculated the ORs and 95% CIs.


RESULTS
616 patients with a mean age of 60.9 +/- 14.4 years participated in our study. Mean treatment time was 237.3 +/- 23.8 min and mean UFR was 7.0 +/- 4.0 ml/kg/h. In stepwise logistic regression, treatment time >4 h reduced the risk of low albumin (OR 0.397, 95% CI 0.235-0.672, p < 0.001). Congestive heart failure (OR 1.634, 95% CI 1.154-2.312, p = 0.006) and acute infection (OR 1.799, 95% CI 1.059-3.056, p = 0.03) were significant correlates of the risk of high CRP. There was no association between UFR and either CRP or albumin.


CONCLUSIONS
Treatment time had a significant cross-sectional association with serum albumin but not with CRP.
Zsom
Lajos
L
Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Zsom
Marianna
M
Fülöp
Tibor
T
Wells
Catherine
C
Flessner
Michael F
MF
Eller
József
J
Wollheim
Charlotta
C
Hegbrant
Jörgen
J
Strippoli
Giovanni F M
GF
D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*; D013997:Time Factors
D012709:Serum Albumin; D002097:C-Reactive Protein