title: Bleeding disorders and reduced bone density.
abstract: In recent decays, quality of life and life expectancy of individuals with severe haemophilia A and B have been improved by better quality in treatment and more availability of blood coagulation products. Recently, new concerns have emerged in current groups such as auto-antibody inhibitors to coagulation factors and reduced bone density (RBD). RBD in bleeding disorders is becoming an escalating burden worldwide due to an increased in life expectancy and also in the ageing population with bleeding disorders. Here, we review published papers on bone mineral density of individuals with haemophilia A & B, a rare bleeding disorder entitled combined factor V and VIII deficiency and other rare bleeding disorders. It seems in individuals with bleeding disorders preventive measures including early detection, treatment and adequate physical activity, encouragement to be active in sports and finally anti-osteoporotic therapy must be done.
authors.affiliation: Immunology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, 91766-99199, Mashhad, Iran. Mansouritorghabe@mums.ac.ir
authors.forename: Hassan
authors.initials: H
authors.lastname: Mansouritorghabeh
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rezaieyazdi
mesh_terms: D001778:Blood Coagulation Disorders / Q000150:complications* / Q000503:physiopathology; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000503:physiopathology; D006801:Humans