Serrated polyps of the colorectum: histological classification and clinical significance.
Serrated polyps of the colorectum are heterogeneous lesions, a subset of which is now regarded as the precursor of colorectal cancer with DNA microsatellite instability. The serrated pathway encompassing hyperplastic aberrant crypt foci, hyperplastic polyps, sessile serrated polyps (adenomas), mixed polyps, and traditional serrated adenomas, with a meticulous review of their up-to-date histological classifications, is presented. Some remarks concerning genetics of serrated polyps and the mechanism leading to carcinoma development are also included.
Orłowska
Janina
J
Janina Orłowska MD, Histopathology Laboratory Department of Gastroenterology and Hepatology, Medical Centre for Postgraduate Education, Oncology Centre, Roentgena 5, 02-781 Warsaw, phone +48 22 546 27 29, e-mail: jorlowska@coi.waw.pl.
D000236:Adenoma; D003111:Colonic Polyps / Q000235:genetics; D015179:Colorectal Neoplasms; D006801:Humans; D006965:Hyperplasia; D053842:Microsatellite Instability