[Effect of hemotransfusion on brain oxygenation and metabolism in patients with intracranial hemorrhages].
The paper analyzes the impact of anemia correction on the time course of changes in oxygen tension in the brain and on the biochemical composition of brain interstitial fluid (tissue microdialysis) in the affected and conditionally intact hemisphere in 8 patients with intracranial hemorrhages and a reduced awakening level up to 4-8 scores by the Glasgow coma scale. Anemia correction in patients with intracranial hemorrhage was shown to fail to change oxygen tension in the brain and to be followed by a reduction in lactate/pyruvate ratio in the involved cerebral hemisphere. Only in significant anemia (Hb < 7 g/dl), hemotransfusion elevated cerebral perfusion pressure, by increasing mean blood pressure.
Petrikov
S S
SS
Titova
Iu V
IuV
Solodov
A A
AA
Guseĭnova
Kh T
KhT
Krylov
V V
VV
D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D001921:Brain / Q000378:metabolism*; D017707:Erythrocyte Transfusion / Q000379:methods*; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D007427:Intracranial Pressure / Q000502:physiology; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D019289:Pyruvic Acid / Q000378:metabolism
D006454:Hemoglobins; D019344:Lactic Acid; D019289:Pyruvic Acid; D010100:Oxygen