title: Increased risk of pre-eclampsia (PE) among women with the history of migraine.
abstract: The Objective of this study was to assess possible association of history of migraine with pre-eclampsia (PE). This was a retrospective study to compare history of migraine in 90 women affected by PE with 90 women without PE as the control group. They recruited by a nonrandomized consecutive sampling method. Data were collected by a questionnaire including demographic, medical, obstetrics, and migraine assessment sections. Data were analyzed using SPSS. Results showed an increased risk of PE in women with history of migraine (odds ratio: 2.87; p < 0.05). Result demonstrated that migraine history in the case group is 14/4% and in control group is 5/6%. Gestational age (GA) at delivery and weight of neonate (WN) were significantly lower compared to control (GA: 37.3 +/- 2.6 vs. 38.7+/- 1.3 weeks T test; P < 0.01) (WN: 2930 +/- 690 vs. 3330 +/- 420; T test; P < 0.0). Cesarean section was more frequent in the PE group compared to the control group [37 (42%) vs. 14 (15.6%)]; chi square; p < 0.01]. The association of migraine with PE is the result of some similar mechanism leading to endothelial dysfunction. Frequent reports of an association between migraine and PE in different populations suggest a history of migraine as a risk factor for PE/gestational hypertension (GH).
authors.affiliation: Department of Reproductive Health and Midwifery, Shahid Beheshti Medical Science University, Tehran, Iran. msimbar@sbmu.ac.ir
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Simbar
authors.forename: Zahra
authors.initials: Z
authors.lastname: Karimian
authors.forename: Maryam
authors.initials: M
authors.lastname: Afrakhteh
authors.forename: Alireza
authors.initials: A
authors.lastname: Akbarzadeh
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Kouchaki
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008881:Migraine Disorders / Q000150:complications* / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000503:physiopathology*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult