Parallel visual cycles in the zebrafish retina.
Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.
Fleisch
Valerie C
VC
Centre for Prions, Protein Folding Disease, University of Alberta, Edmonton, Alberta, Canada.
Neuhauss
Stephan C F
SC
D000818:Animals; D023421:Models, Animal; D009457:Neuroglia / Q000502:physiology; D012160:Retina / Q000166:cytology / Q000502:physiology*; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism / Q000502:physiology*; D012172:Retinaldehyde / Q000378:metabolism; D014785:Vision, Ocular / Q000502:physiology*; D014795:Visual Pathways / Q000033:anatomy & histology / Q000502:physiology; D015027:Zebrafish / Q000033:anatomy & histology*
D012172:Retinaldehyde