title: Dynamic network rewiring determines temporal regulatory functions in Drosophila melanogaster development processes.
abstract: The identification of network motifs has been widely considered as a significant step towards uncovering the design principles of biomolecular regulatory networks. To date, time-invariant networks have been considered. However, such approaches cannot be used to reveal time-specific biological traits due to the dynamic nature of biological systems, and hence may not be applicable to development, where temporal regulation of gene expression is an indispensable characteristic. We propose a concept of a "temporal sequence of network motifs", a sequence of network motifs in active sub-networks constructed over time, and investigate significant network motifs in the active temporal sub-networks of Drosophila melanogaster. Based on this concept, we find a temporal sequence of network motifs which changes according to developmental stages and thereby cannot be identified from the whole static network. Moreover, we show that the temporal sequence of network motifs corresponding to each developmental stage can be used to describe pivotal developmental events.
authors.affiliation: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Man-Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Jeong-Rae
authors.initials: JR
authors.lastname: Kim
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Cho
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D053263:Gene Regulatory Networks / Q000235:genetics / Q000502:physiology*; D008962:Models, Theoretical