[Molecular genetic evolution analysis of new A(H1N1) influenza virus].
In order to analyze the molecular epidemiology of A (H1N1) influenza virus in 2009, the complete genome sequences of influenza strains from different host sources downloaded from the NCBI were analyzed on genetic evolution by DNAstar software in this research. The results showed that 79 mutation sites of new A (H1N1) influenza virus were observed compared to previous human A (H1N1) influenza strain, including 14 mutation sites new in all A (H1N1) influenza sources and 37 mutation sites only observed in swine strain. A significant difference was represented in antigenic sites between new A (H1N1) influenza strain and the previous human A (H1N1) strain. This phenomenon shows the new A (H1N1) influenza strain is either originated from the recombination of human and swine strain or from the infection in pig populations and gradual mutation to human tansmission, which remains to be further studied.
Zhao
Li
L
College of Animal Science and Medicine, Inner Mongolia Agriculture University, Hohhot 010018, China. nmlizhao@126.com
Liu
Yong-Hong
YH
Liu
Yue-Huan
YH
Wang
Feng-Long
FL
Lin
Jian
J
Han
Chun-Hua
CH
Ma
Ming
M
Ding
Yu-Lin
YL
Ding
Xu-Na
XN
Wang
Jin-Ling
JL
Yang
Long-Feng
LF
Pan
Jie
J
Han
Jing-Wen
JW
D000818:Animals; D001717:Birds; D030561:Databases, Nucleic Acid; D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000145:classification / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D005585:Influenza in Birds / Q000821:virology; D007251:Influenza, Human / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000662:veterinary / Q000821:virology; D010802:Phylogeny; D013552:Swine; D013553:Swine Diseases / Q000821:virology
D019267:Hemagglutinin Glycoproteins, Influenza Virus