title: [Expression of lymphangiogenesis marker neuropilin-1 in different types of ovarian cancer].
abstract: BACKGROUND
  Neuropilin (NRP) may be used as a marker of lymphangiogenesis in malignant tumors. Significant correlations of the expression of NRP with tumor progression and overall survival prognosis were found in several cancer types. However; its potential role in epithelial ovarian cancer (EOC) has not been clarified.
  
  
  OBJECTIVE
  The aim of the work was to study a possible correlation of neuropilin-1 (NRP-1) expression with selected clinical and histological features of EOC.
  
  
  METHODS
  The study included 53 women (aged 23 to 81, mean 56.6 +/- 14.4 yrs), 38 of which were postmenopausal (71.7%). Immunohistochemical staining with a specific anti-NRP-1 antibody was performed in representative tumor tissue samples of patients with EOC. Both, percentage of stained lymphatic cells and intensity of staining were assessed under 200x magnification. The results were correlated with the menopausal status, FIGO stage, histological type and histological grade of EOC.
  
  
  RESULTS
  Histological examination revealed that there were 27 cases of serous cancers (50%), 15 cases of mucinous cancer (28.3%) and 11 endometrioid cancers (20.7%). In 41.5% (n = 22) cases of EOC no NRP-1 staining was found, a weak (+) or strong (++) staining were found in 13 (24.5%) and 18 tumors, respectively There were no significant differences between neuropilin-1 expression and both menopausal status of women and histological type of EOC. Except for stage II, clinical EOC patients' FIGO stage was not correlated with the lack of expression (38.8% for stage I, 71.4% for stage II and 35.7% for stage III).
  
  
  CONCLUSIONS
  We believe that neuropilin-1 expression is probably not related to clinical and histological features of epithelial ovarian cancer:
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii Uniwersytetu Medycznego w Lublinie. wbed@wp.pl
authors.forename: Wiesława
authors.initials: W
authors.lastname: Bednarek
authors.forename: Magdalena
authors.initials: M
authors.lastname: Mazurek-Kociubowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sobstyl
authors.forename: Iwona
authors.initials: I
authors.lastname: Wertel
authors.forename: Artur
authors.initials: A
authors.lastname: Czekierdowski
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000378:metabolism / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D042583:Lymphangiogenesis; D008875:Middle Aged; D039942:Neuropilin-1 / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011044:Poland; D016387:Women's Health
chemical_list: D014408:Biomarkers, Tumor; D039942:Neuropilin-1