title: Indication for skin-sparing mastectomy with or without nipple preservation for primary breast cancer.
abstract: Skin-sparing mastectomy (SSM) is one of the available operation methods for breast cancer. We discuss here indications for SSM for primary breast cancer. We carried out SSM for 28 patients with breast cancer. Their clinical features were compared with those in patients who underwent breast-conserving treatment (BCT). Fifteen of the 28 patients received SSM according to schedule. The remaining 13 patients who were scheduled to undergo BCT received SSM because of involvement of the surgical margin. Clinical features indicating suitability for SSM included extensive intraductal cancer growth and multicentricity. The length of intraductal cancer growth in these patients was significantly greater than that in 24 patients who received BCT (2.28 versus 0.571 cm; P = 0.000078). Tumor size and tumor-nipple distance were not indicating factors for this treatment. SSM, which is advantageous in terms of aesthetic outcome and oncologic safety, may be widely indicated after careful evaluation by magnetic resonance imaging or pathologic examination.
authors.affiliation: Department of Respiratory, Breast, and Endocrine Surgery, Kagawa University Faculty of Medicine, 1750-1 Miki-cho, Kita-gun 761-0793, Japan. konbat@med.kagawa-u.ac.jp
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kontani
authors.forename: Chisa
authors.initials: C
authors.lastname: Murazawa
authors.forename: Shoko
authors.initials: S
authors.lastname: Norimura
authors.forename: Kanako
authors.initials: K
authors.lastname: Yamashita
authors.forename: Naomi
authors.initials: N
authors.lastname: Fujiwara-Honjo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohtani
authors.forename: Manabu
authors.initials: M
authors.lastname: Date
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.forename: Gan
authors.initials: G
authors.lastname: Muneuchi
authors.forename: Reiji
authors.initials: R
authors.lastname: Haba
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yokomise
authors.forename: Akira
authors.initials: A
authors.lastname: Yamauchi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008408:Mastectomy / Q000379:methods*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009558:Nipples; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human