title: [Newborns from deliveries with epidural anaesthesia].
abstract: BACKGROUND
  The use of epidural anaesthesia in delivery with the purpose to reduce pain and fear in a pregnant woman has the influence on the physiological status of the woman in childbirth and the course of delivery. From the epidural space of the pregnant woman, one part of free anaesthetic comes in the foetal circulation through the mother's circulation and placenta and connects with the foetal proteins. A lower value of albumins and serum proteins in the foetal circulation give bigger free fraction of anaesthetic which is accumulated in the foetal liver, brain and heart full of blood.
  
  
  OBJECTIVE
  The aim of the study was to examine the influence of epidural anaesthesia on the newborn.
  
  
  METHODS
  Retrospective study of 6398 documents of newborns was performed in our Clinic of Gynaecology and Obstetrics "Narodni front" during 2006. The first group was made of 455 newborns from deliveries with epidural anaesthesia and the second was the control group of 5,943 remaining newborns. In both groups we analysed the following: sex, week of gestation, weight, Apgar score, measure of care and resuscitation, perinatal morbidity and then the obtained results were compared.
  
  
  RESULTS
  Most of deliveries were vaginal without obstetric intervention (86.6%). The number of deliveries finished with vacuum extractor (4.6%) was statistically significantly bigger in the group with epidural anaesthesia than in the control group. Most of the newborns in the first group were born on time (96.5%) in 39.0 +/- 1.0 week of gestation and with foetal weight 3448 +/- 412 grammes. There was no statistical significance in Apgar score between both groups. Epidural anaesthesia does not increase the degree of the newborn's injury. Lower pH of blood was found in the newborns from deliveries with vacuum extractor or operated on (the Ceasarean section).
  
  
  CONCLUSIONS
  Application of epidural anaesthesia decreases duration of delivery and has no adverse effects on the newborn and hypoxic encephalopathy is lower.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Potpara
authors.forename: Miodrag
authors.initials: M
authors.lastname: Grujić
authors.forename: Jelena
authors.initials: J
authors.lastname: Marinković
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojić
authors.forename: Bosiljka
authors.initials: B
authors.lastname: Vijisić-Tesić
authors.forename: Marija
authors.initials: M
authors.lastname: Polovina
authors.forename: Nobojsa
authors.initials: N
authors.lastname: Mujović
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kocijancić
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D001034:Apgar Score; D001724:Birth Weight; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D011247:Pregnancy