A genomic analysis of transcytosis in the pea aphid, Acyrthosiphon pisum, a mechanism involved in virus transmission.
Aphids are the primary vectors of plant viruses. Transmission can occur via attachment to the cuticle lining of the insect (non-circulative transmission) or after internalization in the insect cells with or without replication (circulative transmission). In this paper, we have focused on the circulative and non-propagative mode during which virions enter the cell following receptor-mediated endocytosis, are transported across the cell in vesicles and released by exocytosis without replicating. The correct uptake, transport and delivery of the vesicles cargo relies on the participation of proteins from different families which have been identified in the Acyrthosiphon pisum genome. Assemblage of this annotated dataset provides a useful basis to improve our understanding of the molecules and mechanisms involved in virus transmission by A. pisum and other aphid species.
Tamborindeguy
C
C
USDA-ARS, Robert W. Holley Center for Agriculture and Health Department of Plant Pathology and Plant-Microbe Biology, Cornell University, USA. ctamborindeguy@ag.tamu.edu
Monsion
B
B
Brault
V
V
Hunnicutt
L
L
Ju
H J
HJ
Nakabachi
A
A
Van Fleet
E
E
D000199:Actins / Q000235:genetics / Q000502:physiology; D000818:Animals; D001042:Aphids / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology / Q000821:virology*; D002966:Clathrin / Q000235:genetics / Q000502:physiology; D022163:Clathrin-Coated Vesicles / Q000235:genetics / Q000502:physiology / Q000821:virology; D034281:Dynamins / Q000235:genetics / Q000502:physiology; D004705:Endocytosis / Q000235:genetics / Q000502:physiology; D005089:Exocytosis / Q000235:genetics / Q000502:physiology; D049750:Genome, Insect; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D007303:Insect Vectors / Q000821:virology; D052679:Luteoviridae / Q000472:pathogenicity; D018532:Pisum sativum / Q000469:parasitology / Q000821:virology; D010802:Phylogeny; D010935:Plant Diseases / Q000469:parasitology / Q000821:virology; D010942:Plant Viruses / Q000472:pathogenicity*; D050600:SNARE Proteins / Q000235:genetics / Q000502:physiology; D050857:Synaptotagmins / Q000235:genetics / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000502:physiology
D000199:Actins; D002966:Clathrin; D019476:Insect Proteins; D050600:SNARE Proteins; D050857:Synaptotagmins; D020691:rab GTP-Binding Proteins; D034281:Dynamins