[Dysfunction of coagulation processes in patients after acute coronary syndrome--therapeutic implications].
In the guidelines for patients with acute coronary syndrome (ACS), reperfusion, antiplatelet treatment, completed with parenteral anticoagulant are the standard therapy. It is because ACS is the result of occlusion of related artery by thrombus compound mostly of platelets, with processes of aggregation and adhesion in its pathogenesis. However, many patients after ACS experience major adverse cardiovascular events (MACE) despite optimal long term antiplatelet therapy. The possible reasons seem to be not only the resistance to this drugs but also underestimated coagulation processes. This review describes the dysfunction of particular coagulation parameters in patients with coronary artery disease and their relationship with MACE after ACS.
Kaczmarzyk-Radka
Agata
A
Oddzial Kardiologii z Pododzialem Intensywnego Nadzoru Kardiologicznego, Wojewódzki Szpital Specjalistyczny, Ośrodek Badawczo Rozwojowy we Wrocławiu. agatakaczmarzyk@yahoo.com
Lenartowska
Lucyna
L
Lewczuk
Jerzy
J
D054058:Acute Coronary Syndrome / Q000150:complications* / Q000188:drug therapy; D000925:Anticoagulants / Q000627:therapeutic use; D000991:Antithrombins / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005340:Fibrinogen / Q000378:metabolism; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011498:Protein Precursors / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism; D014841:von Willebrand Factor / Q000276:immunology / Q000378:metabolism
D000925:Anticoagulants; D000991:Antithrombins; D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; D011498:Protein Precursors; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D005344:Fibrinopeptide A; C029733:prothrombin fragment 1; C044183:prothrombin fragment 2; D011516:Prothrombin; D005340:Fibrinogen; D013925:Thromboplastin