[Expression of URG4 in hepatocellular carcinoma and its correlation with HBx].
OBJECTIVE
To investigate the expression of URG4 in HCC (Hepatocellular carcinoma) and its correlation with HBx.


METHODS
Immunohistochemistry was performed to examine the expression of URG4 and HBx in HCC tissues, adjacent nontumor tissues and normal lives tissues.


RESULTS
The expression rate of URG4 in HCC tissues and adjacent nontumor tissues were 48% and 54% respectively, while there was only 22.2% weak URG4 expression in normal tissues. Correlation coefficient between expression of HBx and URG4 was 0.38 in HCC tissues (P<0.05) and 0.45 in adjacent nontumor tissues (P<0.05).


CONCLUSIONS
Expression of URG4 in HCC tissues, adjacent nontumor tissues, and HCC cell lines was much higher than that of normal tissues and cells. Expression of URG4 in HCC is closely related with HBx.
Wang
Yan
Y
Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China. sunwang@fmmu.edu.cn
Li
Zeng-shan
ZS
Liu
Jie
J
Xie
Hua-hong
HH
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006515:Hepatitis B virus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins; D055815:Young Adult
D009363:Neoplasm Proteins; D015534:Trans-Activators; C470990:URGCP protein, human; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein