Long-term outcomes after percutaneous coronary intervention in patients with and without diabetes mellitus in Western Denmark.
Patients with diabetes mellitus have worse outcomes after percutaneous coronary intervention than patients without diabetes mellitus. We compared the risk of stent thrombosis, myocardial infarction, death, and target lesion revascularization in diabetic and nondiabetic patients after implantation of drug-eluting stents or bare metal stents. In the Western Denmark Heart Registry, 12,347 consecutive patients (1,575 with and 10,772 without diabetes) were identified and followed up for 2 years. The 2-year risk of definite stent thrombosis was 0.52% in patients with diabetes mellitus and 0.71% in nondiabetic patients (adjusted relative risk [RR] 0.74, 95% confidence interval [CI] 0.41 to 1.34, p = 0.321). The 2-year risk of myocardial infarction was greater in the diabetic patients (6.9%) than in the nondiabetic patients (3.6%; adjusted RR 1.96, 95% CI 1.58 to 2.43; p <0.001). The all-cause 2-year mortality rate was almost twice as great for the diabetic patients compared to the nondiabetic patients (12.4% vs 6.7%; adjusted RR 1.91, 95% CI 1.63 to 2.23; p <0.001). The 2-year risk of target lesion revascularization was 8.5% in the diabetic patients and 6.8% in the nondiabetic patients (adjusted RR 1.28, 95% CI 1.10 to 1.49; p <0.001). In conclusion, 2 years after drug-eluting stent or bare metal stent implantation, diabetic patients had a greater risk than nondiabetic patients of myocardial infarction and death. Drug-eluting stent treatment reduced the risk of target lesion revascularization compared to bare metal stent treatment, regardless of diabetes status.
Jensen
Lisette Okkels
LO
Department of Cardiology, Odense University Hospital, Odense, Denmark. okkels@dadlnet.dk
Maeng
Michael
M
Thayssen
Per
P
Kaltoft
Anne
A
Tilsted
Hans Henrik
HH
Lassen
Jens Flensted
JF
Hansen
Knud Noerregaard
KN
Bottcher
Morten
M
Rasmussen
Klaus
K
Madsen
Morten
M
Johnsen
Søren Paaske
SP
Sørensen
Henrik Toft
HT
Thuesen
Leif
L
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003328:Coronary Thrombosis / Q000209:etiology / Q000401:mortality; D003718:Denmark / Q000453:epidemiology; D048909:Diabetes Complications / Q000401:mortality* / Q000628:therapy*; D054855:Drug-Eluting Stents / Q000009:adverse effects; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome