title: Neural control of the female urethral and anal rhabdosphincters and pelvic floor muscles.
abstract: The urethral rhabdosphincter and pelvic floor muscles are important in maintenance of urinary continence and in preventing descent of pelvic organs [i.e., pelvic organ prolapse (POP)]. Despite its clinical importance and complexity, a comprehensive review of neural control of the rhabdosphincter and pelvic floor muscles is lacking. The present review places historical and recent basic science findings on neural control into the context of functional anatomy of the pelvic muscles and their coordination with visceral function and correlates basic science findings with clinical findings when possible. This review briefly describes the striated muscles of the pelvis and then provides details on the peripheral innervation and, in particular, the contributions of the pudendal and levator ani nerves to the function of the various pelvic muscles. The locations and unique phenotypic characteristics of rhabdosphincter motor neurons located in Onuf's nucleus, and levator ani motor neurons located diffusely in the sacral ventral horn, are provided along with the locations and phenotypes of primary afferent neurons that convey sensory information from these muscles. Spinal and supraspinal pathways mediating excitatory and inhibitory inputs to the motor neurons are described; the relative contributions of the nerves to urethral function and their involvement in POP and incontinence are discussed. Finally, a detailed summary of the neurochemical anatomy of Onuf's nucleus and the pharmacological control of the rhabdosphincter are provided.
authors.affiliation: Urogenix, Inc., Durham, North Carolina, USA. karl.thor@urogenix.com
authors.forename: Karl B
authors.initials: KB
authors.lastname: Thor
authors.forename: William C
authors.initials: WC
authors.lastname: de Groat
mesh_terms: D001003:Anal Canal / Q000294:innervation*; D000818:Animals; D003672:Defecation / Q000187:drug effects; D005260:Female; D006801:Humans; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D009433:Neural Inhibition; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D036801:Parturition; D017773:Pelvic Floor / Q000294:innervation*; D056887:Pelvic Organ Prolapse / Q000503:physiopathology; D010641:Phenotype; D012018:Reflex; D012677:Sensation; D014521:Urethra / Q000294:innervation*; D014549:Urinary Incontinence / Q000503:physiopathology; D014554:Urination / Q000187:drug effects