title: Invasive pneumococcal disease after implementation of a reduced three-dose pneumococcal conjugate vaccine program: a pediatric tertiary care center experience.
abstract: Following the implementation of a government-sponsored reduced three-dose (2 + 1) heptavalent conjugate pneumococcal vaccine (PCV7) program, we report a 61.4% decrease in the number of cases of invasive pneumococcal diseases (IPD) treated at our institution. Four years after the implementation of the three-dose reduced vaccine program, only 7.4% of IPD were caused by PCV7 serotypes, and there was an increase in the proportion of IPD caused by nonPCV7 serotypes; serotype 19A represented 40.7% of the strains isolated during the last year of the study. These results, similar to those previously observed with a regular four-dose (3 + 1) PCV7 schedule, are reassuring as to the effectiveness of a reduced three-dose (2 + 1) PCV7 program. Increasing numbers of IPD caused by nonPCV7 serotypes warrant the use of a new conjugate pneumococcal vaccine that contains serotype 19A.
authors.affiliation: Infectious Diseases Division, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, 3175 côte Sainte-Catherine, Montréal, Québec, Canada.
authors.forename: Pierre Alex
authors.initials: PA
authors.lastname: Crisinel
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chevalier
authors.forename: Fabien
authors.initials: F
authors.lastname: Rallu
authors.forename: Bruce
authors.initials: B
authors.lastname: Tapiero
authors.forename: Valérie
authors.initials: V
authors.lastname: Lamarre
authors.forename: Roseline
authors.initials: R
authors.lastname: Thibault
authors.forename: Philippe
authors.initials: P
authors.lastname: Ovetchkine
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007223:Infant; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011792:Quebec / Q000453:epidemiology; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000276:immunology*; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods*; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate