Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence.
Research into the biological processes that increase susceptibility to methamphetamine dependence has been conducted primarily in Asian populations. Using a case-control design this study's purpose was to explore, among a population of methamphetamine-dependent Caucasians, six putative single nucleotide polymorphisms previously found to be associated with methamphetamine dependence in Asian populations. A total of 193 non-psychotic males (117 methamphetamine-dependent and 76 controls) were genotyped for variants located in six genes (AKT1, ARRB2, BDNF, COMT, GSTP1, OPRM1). Genotypic and allelic frequencies, odds ratios, and 95% confidence intervals were calculated. None of the putative gene associations was significantly replicated in our sample of Caucasian men. Effect size comparisons suggest a trend toward allelic divergence for arrestin beta 2 (ARRB2) and glutathione S-transferase P1 (GSTP1) and allelic convergence for brain-derived neurotrophic factor (BDNF). Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups.
Bousman
Chad A
CA
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA. cbousman@ucsd.edu
Glatt
Stephen J
SJ
Cherner
Mariana
M
Atkinson
J Hampton
JH
Grant
Igor
I
Tsuang
Ming T
MT
Everall
Ian P
IP
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D019390:Arrestins / Q000235:genetics*; D044466:Asian People; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People; D000071560:beta-Arrestin 2; D000071557:beta-Arrestins
C000605254:ARRB2 protein, human; D019390:Arrestins; D019208:Brain-Derived Neurotrophic Factor; D000071560:beta-Arrestin 2; D000071557:beta-Arrestins; D008694:Methamphetamine; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi