title: Synthesis of gem-difluoromethylenated analogues of boronolide.
abstract: The straightforward synthesis of four gem-difluoromethylenated analogues 4-7 of boronolide is described. The key steps of the synthesis include the concise preparation of the key intermediates 12a-b through the indium-mediated gem-difluoropropargylation of aldehyde 9 with the fluorine-containing building block 11 and the efficient construction of alpha,beta-unsaturated-delta-lactones 15a-b via BAIB/TEMPO-procedure.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Qiu
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing