title: Bullous pemphigoid as a dermadrome associated with spindle cell carcinoma of the gallbladder.
abstract: Skin disorders that appear in association with internal malignancies are called dermadromes. Bullous pemphigoid (BP), which is a major autoimmune disease of the skin, is considered to be a dermadrome, although there have been conflicting reports. We report a case of BP that preceded the diagnosis of an internal malignancy. Although we could not detect any malignancies on chest, abdominal or pelvic computer tomography on the first hospital admission, intensive screening on the third admission revealed a gallbladder malignancy. Laparoscopic cholecystectomy was performed. Histopathology showed a spindle cell carcinoma of the gallbladder. To the best of our knowledge, this is the first report of a spindle cell carcinoma of the gallbladder in a patient with BP.
authors.affiliation: Department of Dermatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Umekoji
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsuruta
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
authors.forename: Takeo
authors.initials: T
authors.lastname: Nishimori
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000369:Aged, 80 and over; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D017081:Cholecystectomy, Laparoscopic; D004802:Eosinophilia / Q000473:pathology; D017809:Fatal Outcome; D005706:Gallbladder Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D010391:Pemphigoid, Bullous / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D011239:Prednisolone