title: A new tool for photoaffinity labeling studies: a partially constrained, benzophenone based, alpha-amino acid.
abstract: The novel alpha-amino acid BpAib, a partially conformationally restricted analogue of the currently extensively used 3-(4-benzoylphenyl)alanine (Bpa) photoaffinity label, was synthesized, optically resolved, fully characterized, and appropriately derivatized. An intermolecular photocrosslinking experiment highlighted its regioselective reactivity towards the S-methyl side-chain group of a Met-based dipeptide, which is closely comparable to that of Bpa.
authors.affiliation: ILV, UMR CNRS 8180, University of Versailles, 78035 Versailles, France. wright@chimie.uvsq.fr
authors.forename: Karen
authors.initials: K
authors.lastname: Wright
authors.forename: Alessandro
authors.initials: A
authors.lastname: Moretto
authors.forename: Marco
authors.initials: M
authors.lastname: Crisma
authors.forename: Michel
authors.initials: M
authors.lastname: Wakselman
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Mazaleyrat
authors.forename: Fernando
authors.initials: F
authors.lastname: Formaggio
authors.forename: Claudio
authors.initials: C
authors.lastname: Toniolo
mesh_terms: D000409:Alanine / Q000138:chemical synthesis* / Q000737:chemistry*; D001577:Benzophenones / Q000737:chemistry*; D019920:Photoaffinity Labels / Q000138:chemical synthesis* / Q000737:chemistry*; D055668:Photochemical Processes; D013057:Spectrum Analysis
chemical_list: D001577:Benzophenones; D019920:Photoaffinity Labels; C047723:benzophenone; D000409:Alanine