title: Two new flavan-4-ol glycosides from Abacopteris penangiana.
abstract: Two new flavan-4-ol glycosides, (2R,4S)-6,8-dimethyl-7-hydroxy-4'-methoxy-4,2''-oxidoflavan-5-O-beta-D-6''-O-acetyl-glucopyranoside (1) and (2R,4S)-5,7-O-beta-D-di-glucopyranosyloxy-4'-methoxy-6,8-dimethyl-4,2''-oxidoflavane (2), were isolated from the rhizomes of Abacopteris penangiana. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 showed significant anticancer activities against HeLa and L929 cell lines in vitro.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Fang
authors.forename: Jia-Chun
authors.initials: JC
authors.lastname: Chen
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029624:Ferns / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C549867:(2R,4S)-5,7-O-beta-D-di-glucopyranosyloxy-4'-methoxy-6,8-dimethyl-4,2''-oxidoflavane; C549868:(2R,4S)-6,8-dimethyl-7-hydroxy-4'-methoxy-4,2''-oxidoflavan-5-O-beta-D-6''-O-acetyl-glucopyranoside; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides