Association of nuclear factor κB expression with a poor outcome in nasopharyngeal carcinoma.
The aim of this study was to determine the relationship between nuclear factor κB and the prognosis of patients with nasopharyngeal carcinoma. We used immunohistochemical studies to examine nuclear factor κB expression in 42 patients with nasopharyngeal carcinoma. The results showed that tumors positive for nuclear factor κB were associated with an increased relapse potential, poor disease-free survival, and reduced overall survival in nasopharyngeal carcinoma. Our study indicates that nuclear factor κB could be an independent molecular marker for predicting poor prognosis among patients with nasopharyngeal carcinoma. Understanding the biology of nuclear factor κB-mediated pathways may lead to the development of novel therapeutic strategies for nasopharyngeal carcinoma.
Zhang
Y
Y
Department of Oncology, Mian Yang Central Hospital, West China Medical School, Sichuan University, Sichuan, 621000, People's Republic of China.
Lang
J Y
JY
Liu
L
L
Wang
J
J
Feng
G
G
Jiang
Y
Y
Deng
Y L
YL
Wang
X J
XJ
Yang
Y H
YH
Dai
T Z
TZ
Xie
G
G
Pu
J
J
Du
X B
XB
D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000096:biosynthesis*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D016328:NF-kappa B