title: Acute saddle pulmonary embolism in Ewing sarcoma.
abstract: Two young adults had similar presentations of Ewing sarcoma, with spinal cord involvement and significant neurologic deficits. Shortly after workup, stabilization, and initiation of chemotherapy, both developed acute saddle pulmonary embolism, despite prophylactic anticoagulation. In both cases, prompt intravenous thrombolysis and therapeutic anticoagulation successfully managed this complication. Review of the presentation, treatment options, and most current guidelines for acute saddle pulmonary embolism follow the case presentations.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, University of British Columbia, Vancouver, Canada. dvilla@bccancer.bc.ca
authors.forename: Diego
authors.initials: D
authors.lastname: Villa
authors.forename: Meg
authors.initials: M
authors.lastname: Knowling
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology*; D012512:Sarcoma, Ewing / Q000150:complications* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000925:Anticoagulants