title: Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
abstract: Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1).
authors.affiliation: Departamento de Quimica, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/n, Rosa Elze, 49100-000, Sao Cristovao, SE, Brazil. emmanoelvilaca@yahoo.com.br
authors.forename: Emmanoel Vilaça
authors.initials: EV
authors.lastname: Costa
authors.forename: Maria Lúcia B
authors.initials: ML
authors.lastname: Pinheiro
authors.forename: Andersson
authors.initials: A
authors.lastname: Barison
authors.forename: Francinete R
authors.initials: FR
authors.lastname: Campos
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Salvador
authors.forename: Beatriz Helena L N S
authors.initials: BH
authors.lastname: Maia
authors.forename: Elaine C
authors.initials: EC
authors.lastname: Cabral
authors.forename: Marcos N
authors.initials: MN
authors.lastname: Eberlin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry; D001938:Brazil; D002175:Candida / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D031043:Guatteria / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
chemical_list: C550959:9-methoxy-O-methylmoschatoline; C550960:9-methoxyisomoschatoline; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D001060:Aporphines; C550961:isocerasonine; C062700:xylopine