title: [Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure].
abstract: OBJECTIVE
  To investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.
  
  
  METHODS
  32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.
  
  
  RESULTS
  Left ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.
  
  
  CONCLUSIONS
  Metoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.
authors.affiliation: Department of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China. gwqbj08@sina.com
authors.forename: Wen-qian
authors.initials: WQ
authors.lastname: Gao
authors.forename: Chun-guang
authors.initials: CG
authors.lastname: Han
authors.forename: Yue-xiang
authors.initials: YX
authors.lastname: Zhao
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Ting-shu
authors.initials: TS
authors.lastname: Yang
authors.forename: Yong-xue
authors.initials: YX
authors.lastname: Liu
mesh_terms: D000369:Aged, 80 and over; D002908:Chronic Disease; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008790:Metoprolol / Q000494:pharmacology*
chemical_list: C496567:GRK2 protein, human; D054769:G-Protein-Coupled Receptor Kinase 2; D008790:Metoprolol