Interactions of Fox proteins with inflammatory transcription-factor pathways.
The forkhead (Fox) protein family includes a wide diversity of 'winged helix' transcription factors, now known to play critical roles in immune homeostasis. Although Foxp3 remains the most widely studied member for its role in the development and/or function of regulatory T cells, which extrinsically modulate the activity of effector leukocytes, other family members, such as Foxj1, Foxo3a and Foxd1, have received growing attention for their importance in the cell-intrinsic regulation of immune homeostasis, especially in T cells, by antagonizing the activity of proinflammatory transcription-factor pathways, such as the nuclear factor-kappaB or nuclear factor of activated T-cell families. This review summarizes a present understanding of these factors in this context.
Peng
Stanford L
SL
Arthritis Research Inflammation, Autoimmunity and Transplantation Research Roche Palo Alto, LLC3431 Hillview Ave, Mailstop R7-101 Palo Alto, CA 94304, USA. stanford.peng@roche.com