Temporal bone pneumatization and its relationship to paranasal sinus development in cystic fibrosis.
BACKGROUND
There is significant debate on the influence of inflammatory mucosal disease on paranasal sinus pneumatization (PSP) and temporal bone pneumatization (TBP) in cystic fibrosis patients (CF). It is often assumed that mucosal disease of the paranasal sinuses will negatively influence development and pneumotization of the paranasal sinuses and temporal bone system.


METHODS
A case-control study of TBP and PSP in CF, chronic rhinosinusitis (CRS) and healthy control patients from a tertiary rhinology clinic. TBP and PSP were assessed by computed tomography (CT) using a previously validated scale. Genotype data for patients with CF was determined.


RESULTS
In total, 186 temporal bones and paranasal sinuses from 93 adult patients were assessed through evaluation of CT scans. Tha patients had a mean age of 43.4 +/- 14.9 yrs. The interobserver correlation for TB scoring was 0.86. TBP did not differ between CF, CRS and controls (chi(2) = 6.93, p = 0.38). PSP was less in the CF group (chi(2) = 34.2, p < 0.001) than the CRS and control groups. CRS and controls did not differ in PSP. 51.6% of CF patients were homozygous for DeltaF508 and 16.1% were heterozygous. The DeltaF508 status correlated with poorer SP (chi(2) = 34.2, p < 0.001), but greater TBP (chi(2) = 14.9, p = 0.002)


CONCLUSIONS
PSP is impaired in CF and DeltaF508 homozygosity is related to poor PSP. TBP is well preserved in the CF population and DeltaF508 homozygosity correlates with greater TBP, with the underlying mechanisms being unclear. Genotype might play a role in skull base pneumatization.
Seifert
Clarice M
CM
Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Harvey
Richard J
RJ
Mathews
Joe W
JW
Meyer
Ted A
TA
Ahn
Chadwick
C
Woodworth
Brad A
BA
Schlosser
Rodney J
RJ
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003550:Cystic Fibrosis / Q000235:genetics / Q000473:pathology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000473:pathology*; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000473:pathology*; D013701:Temporal Bone / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed