Frequency of occult high-grade squamous intraepithelial neoplasia and invasive cancer within anal condylomata in men who have sex with men.
Human papillomavirus causes anal condylomata, high-grade anal intraepithelial neoplasia, and anal squamous cell cancer. We found high-grade intraepithelial neoplasia or squamous cell cancer in 75 (47%) of 159 HIV-seropositive men who have sex with men (MSM) and in 42 (26%) of 160 HIV-seronegative MSM with anal condylomata meriting surgery (P<.001, determined by use of the chi(2) test). Anal condylomata in MSM often harbor high-grade intraepithelial neoplasia and squamous cell cancer.
Schlecht
Hans P
HP
Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel College of Medicine, Philadelphia, Pennsylvania, USA.
Fugelso
Dana K
DK
Murphy
Ryan K
RK
Wagner
Katiri T
KT
Doweiko
John P
JP
Proper
Joann
J
Dezube
Bruce J
BJ
Panther
Lori A
LA
D000293:Adolescent; D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus; D001004:Anus Diseases / Q000150:complications* / Q000601:surgery / Q000821:virology; D001005:Anus Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D003218:Condylomata Acuminata / Q000150:complications* / Q000601:surgery / Q000821:virology; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000150:complications*; D012189:Retrospective Studies; D055815:Young Adult