Spectroscopy of human plasma for diagnosis of idiopathic Parkinson's disease.
BACKGROUND
No established chemical biomarkers of idiopathic Parkinson's disease (PD) currently exist. Augmented oxidative stress (OS) has been implicated in both neural and peripheral PD tissues.


METHODS
In this study, Raman scattering and near-infrared spectroscopy were used to detect and quantify oxidative substrate modifications in blood plasma samples from PD and normal elderly control (NEC) subjects.


RESULTS
Hypothesis-driven preselection of OS-sensitive bandwidths distinguished PD from NEC subjects with approximately 75% sensitivity and specificity using both complementary spectroscopic techniques.


CONCLUSIONS
Biospectroscopy of plasma may provide a rapid, minimally invasive and inexpensive chemical biomarker of idiopathic PD.
Schipper
Hyman M
HM
Centre for Neurotranslational Research, Lady Davis Institute, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada.
Kwok
C Shing
CS
Rosendahl
Scott M
SM
Bandilla
Dirk
D
Maes
Olivier
O
Melmed
Calvin
C
Rabinovitch
Daniel
D
Burns
David H
DH