Anti-adhesive effect and safety of sodium hyaluronate and sodium carboxymethyl cellulose solution in thyroid surgery.
OBJECTIVE
A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the anti-adhesive effect and safety of a newly developed HA-CMC solution in thyroidectomy.


METHODS
Seventy-four patients who underwent thyroidectomy were prospectively randomized. In the study group of 38 patients, 5 mL HA-CMC solution was applied to the operative field after thyroidectomy. The subjects were asked about adhesive symptoms using a four-item questionnaire at 2 weeks, 2 months and 6 months after surgery. In addition, three items on the appearance of neck wrinkles and scars were evaluated by a physician. Each item was scored from 0 to 10.


RESULTS
The mean (+/- standard deviation) total adhesion score at each visit was 15.22 +/- 8.99, 10.42 +/- 8.41, and 7.24 +/- 5.83 for the control group and 19.29 +/- 9.71, 9.46 +/- 5.71, and 6.03 +/- 4.32 for the study group. Total adhesion scores for both groups decreased with time (p < 0.001), but no significant differences were noted between the two groups (p > 0.066). There were no complications related to the HA-CMC solution.


CONCLUSIONS
The HA-CMC solution did not decrease subjective or objective postoperative adhesion in patients undergoing thyroid surgery, although it was biologically safe.
Park
Won Seo
WS
Department of Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
Chung
Yoo Seung
YS
Lee
Kyu Eun
KE
Kim
Hoon Yub
HY
Choe
Jun-Ho
JH
Koh
Suck Hwan
SH
Youn
Yeo-Kyu
YK
D000328:Adult; D000368:Aged; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013965:Thyroidectomy / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium