title: [(3)H]ketanserin binding increases in monkey cortex following basal forebrain lesions with ibotenic acid.
abstract: The present study investigated the effects of damage to the basal forebrain cholinergic system upon [(3)H]ketanserin binding in the neocortex and hippocampus of monkeys. [(3)H]Ketanserin specifically binds to serotonin type-2 receptor sites. Lesions were placed in the medial septal area, nucleus basalis, or both regions. Ten months later, [(3)H]ketanserin binding was increased in the neocortex, but not in the hippocampus, while levels of choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, EC 2.3.1.6) activity decreased in the neocortex and hippocampus. Changes in the levels of choline acetyltransferase and [(3)H]ketanserin binding were correlated significantly in the neocortex (r = ?0.64, P < 0.025), but not in the hippocampus. The data suggest that degeneration of the basal forebrain cholinergic system may alter serotonergic function in the neocortex.
authors.affiliation: Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, U.S.A.
authors.forename: G L
authors.initials: GL
authors.lastname: Wenk
authors.forename: K L
authors.initials: KL
authors.lastname: Engisch
authors.forename: L D
authors.initials: LD
authors.lastname: McCall
authors.forename: S J
authors.initials: SJ
authors.lastname: Mitchell
authors.forename: T G
authors.initials: TG
authors.lastname: Aigner
authors.forename: R L
authors.initials: RL
authors.lastname: Struble
authors.forename: D L
authors.initials: DL
authors.lastname: Price
authors.forename: D S
authors.initials: DS
authors.lastname: Olton