title: Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: L-Proline and MnCl(2).
abstract: Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together, either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of L-Proline and MnCl(2). In that context, a new crystalline structure of a multicomponent molecular complex composed of L-Proline and MnCl(2) is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally, our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes, in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.
authors.affiliation: Department of Chemistry, University of Namur, rue de Bruxelles, 61, B-5000 Namur, Belgium.
authors.forename: Anaëlle
authors.initials: A
authors.lastname: Tilborg
authors.forename: Catherine
authors.initials: C
authors.lastname: Michaux
authors.forename: Bernadette
authors.initials: B
authors.lastname: Norberg
authors.forename: Johan
authors.initials: J
authors.lastname: Wouters
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002712:Chlorides / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D018360:Crystallography, X-Ray; D017895:Manganese Compounds / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; D011392:Proline; C025340:manganese chloride