title: A nationwide, retrospective analysis of symptoms, comorbidities, medical care and autopsy findings in cases of fatal pulmonary embolism in younger patients.
abstract: OBJECTIVE
  Our objective was to provide a comprehensive description of fatal pulmonary embolism (PE) in younger persons. Specifically, we recorded information on symptoms, comorbidity, medical contact, if this had been required, and subsequent autopsy findings.
  
  
  METHODS
  We reviewed all death certificates from persons aged 0-35 years who had died between 1 January 2000 and 31 December 2006, and retrospectively identified all cases of fatal PE. Additional information was retrieved from the National Patient Registry, autopsy reports, and clinical charts.
  
  
  RESULTS
  Sixty-one cases of fatal PE were included; 38% of these were in males. The median age was 29 years. The predominant symptoms were dyspnea, syncope, leg pains, and chest pains. Sixty-three per cent of patients reportedly experienced symptoms for days, weeks, or months. More than half of the patients had sought medical care, and at the time of medical evaluation the majority of the patients were not hemodynamically compromised. In 21% cases, the correct diagnosis was reached before death; however, in only 5% of cases was this accomplished before clinical deterioration. Furthermore, clinical history and subsequent postmortem examinations showed that approximately half of younger persons dying from PE were otherwise healthy, and in no case was occult cancer diagnosed.
  
  
  CONCLUSIONS
  Our data show that a substantial proportion of younger victims of fatal PE had experienced symptoms for an extended period of time. Furthermore, the correct diagnosis remained elusive in the majority of cases, even though approximately half of the subjects had sought medical evaluation for symptoms that, in retrospect, were most likely caused by a venothrombotic event.
authors.affiliation: The Danish National Research Foundation Centre for Cardiac Arrhythmia, DARC, Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. julianetheilade@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Theilade
authors.forename: B G
authors.initials: BG
authors.lastname: Winkel
authors.forename: A G
authors.initials: AG
authors.lastname: Holst
authors.forename: J
authors.initials: J
authors.lastname: Tfelt-Hansen
authors.forename: J H
authors.initials: JH
authors.lastname: Svendsen
authors.forename: S
authors.initials: S
authors.lastname: Haunsø
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D015992:Body Mass Index; D002908:Chronic Disease / Q000401:mortality; D015897:Comorbidity; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000401:mortality*; D012189:Retrospective Studies; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000175:diagnosis / Q000401:mortality