Synthesis of a novel biodegradable polyurethane with phosphatidylcholines.
A novel polyurethane was successfully synthesized by chain-extension of biodegradable poly (l-lactide) functionalized phosphatidylcholine (PC) with hexamethylene diisocyanate (HDI) as chain extender (PUR-PC). The molecular weights, glass transition temperature (Tg) increased significantly after the chain-extension. The hydrophilicity of PUR-PC was better than the one without PC, according to a water absorption test. Moreover, the number of adhesive platelets and anamorphic platelets on PUR-PC film were both less than those on PUR film. These preliminary results suggest that this novel polyurethane might be a better scaffold than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility. Besides, this study also provides a new method to prepare PC-modified biodegradable polyurethanes.
Cao
Jun
J
Sichuan University, Chengdu, China. caojun198610301981@126.com
Chen
Niancao
N
Chen
Yuanwei
Y
Luo
Xianglin
X
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001673:Biodegradation, Environmental; D057927:Hydrophobic and Hydrophilic Interactions; D010713:Phosphatidylcholines / Q000737:chemistry*; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D023822:Tissue Engineering; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D010713:Phosphatidylcholines; D011140:Polyurethanes; D014867:Water