title: [Epilepsy onset between one month and three months of life: our 11 years experience].
abstract: BACKGROUND
  The prognosis of epilepsy is basically determined by its aetiology. Early onset of seizures is generally associated with poor progress.
  
  
  METHODS
  We review our experience in epilepsy with children born after 1 January 1997 and who had their first seizure between 1 and 3 months of age before January 2008.
  
  
  RESULTS
  Eighteen cases diagnosed with epilepsy and a first seizure between 1 and 3 months of age were included. One case was within the Dravet syndrome spectrum with the c829 T>G c277G heterozygous mutation of the SCN1A gene. Four were cryptogenic epilepsies and thirteen were asymptomatic: 2 were inborn errors of metabolism (biotinidase deficiency with a response to biotin and Leigh's syndrome); 2 were of infectious origin and the remaining nine prenatal encephalopathy. Nine (50%) currently have a severe psychomotor delay and 2 died. The cryptogenic cases had a relatively poor progress.
  
  
  CONCLUSIONS
  Our experience corroborates the poor prognosis associated with early onset, between 1 and 3 months, of epileptic seizures. Given the wide aetiological range and the poor prognosis in the absence of specific treatment, an appropriate diagnostic-therapeutic strategy is required to avoid diagnostic uncertainties and can identify potentially treatable cases, such as some inborn errors of metabolism. In this age group, the protocol for convulsions of unknown cause must be the same as that for neonatal convulsions, including treatment with a vitamin cocktail, after collecting biological samples.
authors.affiliation: Grupo de Investigación Neurometabólico, Instituto Aragónes de Ciencias de la Salud, España.
authors.forename: R
authors.initials: R
authors.lastname: Pérez Delgado
authors.forename: M
authors.initials: M
authors.lastname: Lafuente Hidalgo
authors.forename: J
authors.initials: J
authors.lastname: López Pisón
authors.forename: B
authors.initials: B
authors.lastname: Sebastián Torres
authors.forename: S
authors.initials: S
authors.lastname: Torres Claveras
authors.forename: M C
authors.initials: MC
authors.lastname: García Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Baldellou Vázquez
authors.forename: J L
authors.initials: JL
authors.lastname: Peña Segura
mesh_terms: D004827:Epilepsy / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011379:Prognosis; D013577:Syndrome