CD4+CD25+ regulatory T-cell therapy.
Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4(+)CD25(+) Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.
Jiang
Shuiping
S
Immunoregulation Laboratory, Department of Nephrology and Transplantation, King's College, Guy's Hospital, London SE1 9RT, UK. shuiping.jiang@kcl.ac.uk
Lechler
Robert I
RI
Lombardi
Giovanna
G