title: Reactive proliferation of endothelial cells and pericytes associated with arteriovenous malformation.
abstract: Arteriovenous malformation (AVM) is a structural vascular abnormality with no proliferation of cellular components. We report on a 53-year-old man who presented with a 15-year history of a progressively enlarging nodule on his lower lip. A dark-reddish, easy-bleeding nodule diagnosed as AVM was resected to reduce the volume and troublesome bleeding. Histologically, the nodule revealed that the proliferating cellular area was composed of endothelial cells and pericytes in addition to the area of dilated vessels. We speculated that the cell proliferation developed secondary to AVM. We also discuss the histological differential diagnosis of spindle cell hemangioma and pseudo-Kaposi's sarcoma.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. myasuda@showa.gunma-u.ac.jp
authors.forename: Masahito
authors.initials: M
authors.lastname: Yasuda
authors.forename: Etsuko
authors.initials: E
authors.lastname: Okada
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nagai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000199:Actins / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D001165:Arteriovenous Malformations / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D042783:Endothelial Cells / Q000473:pathology*; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D008046:Lip / Q000002:abnormalities* / Q000098:blood supply / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020286:Pericytes / Q000473:pathology*; D012514:Sarcoma, Kaposi / Q000175:diagnosis
chemical_list: D000199:Actins; D018952:Antigens, CD34