[Analysis of causative allergen of the patient with baker's asthma and wheat-dependent exercise-induced anaphylaxis (WDEIA)].
A 47 years-old woman suffering from baker's asthma for several years developed anaphylaxis when she was walking hard after taking wheat. On the provocation test, neither wheat alone nor exercise alone induced any symptoms. The combination of exercise, wheat and aspirin induced urticaria and marked elevation of blood gliadin levels. According to the high titer of omega-5 gliadin specific IgE in her serum and the result of challenge test, we diagnosed wheat-dependent exercise-induced anaphylaxis (WDEIA). By means of western blotting of soluble and insoluble wheat proteins, we detected several bands which were supposed to be beta-, gamma- and omega-5 gliadin by their relative molecular mass. Wheat gliadins might be causative allergen of both baker's asthma and WDEIA in our case.
Ueno
Mitsuhiko
M
Department of Dermatology, Hyogo Prefectural Kakogawa Hospital, Japan. ueno8ueno@yahoo.co.jp
Adachi
Atsuko
A
Fukumoto
Takeshi
T
Nishitani
Nao
N
Fujiwara
Norihiro
N
Matsuo
Hiroaki
H
Kohno
Kunie
K
Morita
Eishin
E
D000485:Allergens / Q000032:analysis* / Q000276:immunology; D001250:Asthma, Exercise-Induced / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D021182:Wheat Hypersensitivity / Q000276:immunology*
D000485:Allergens