title: Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis.
abstract: OBJECTIVE
  To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases.
  
  
  METHODS
  We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model.
  
  
  RESULTS
  We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), -881 (A/G, 3 studies), -826 (C/T, 3 studies), and -297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, -881, -297 with autoimmune and inflammatory diseases. An association of NFKBIA gene -826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97-3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07-4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78-6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78-10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22-3.36, P = 0.006).
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene -826C/T polymorphism, but not with 2758A/G, -881A/G, and -279C/T.
authors.affiliation: Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023 Jiangsu, China.
authors.forename: Guo-Long
authors.initials: GL
authors.lastname: Zhang
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Zou
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Feng
authors.forename: He-Jian
authors.initials: HJ
authors.lastname: Shi
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Du
authors.forename: Min-Hua
authors.initials: MH
authors.lastname: Shao
authors.forename: Yong
authors.initials: Y
authors.lastname: Gu
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics*; D007249:Inflammation / Q000235:genetics*; D000072000:NF-KappaB Inhibitor alpha; D011110:Polymorphism, Genetic; D039781:PubMed
chemical_list: D020672:I-kappa B Proteins; C000606204:NFKBIA protein, human; D000072000:NF-KappaB Inhibitor alpha