title: Distributions of human leukocyte antigen-A, -B, and -DRB1 alleles and haplotypes based on 46,915 Taiwanese donors.
abstract: Human leukocyte antigen (HLA)-A, -B, and -DRB1 alleles were typed in 46,915 healthy Taiwanese volunteers recruited for Tzu Chi Taiwan Marrow Donor Registry (TCTMDR). The volunteers were separated into Taiwanese and Taiwanese aborigines. In this study, a total of 51 A, 121 B, and 53 DRB1 alleles were found in the Taiwanese group, and 17 A, 32 B, and 23 DRB1 alleles were identified in the Taiwanese aborigines. Some commonly shared alleles appeared more frequently in one group than in the other. The two haplotypes, among the 20 most frequently observed haplotypes in each group, shared in common by both groups were A*3303-B*5801-DRB1*0301 and A*0207-B*4601-DRB1* 0901. However, both haplotype frequencies in each group were extremely different, indicating the existence of genetic diversity between the two groups. In addition, principal component analysis and clustering results based on high-resolution HLA-A, -B, and -DRB1 alleles indicated that the Taiwanese group was closest to Southern Chinese and reiterated HLA diversity between the Taiwanese and the Taiwanese aborigines. We believe that our findings in this study may provide useful information in search for HLA-matched donors for patients.
authors.affiliation: Department of Laboratory of Medicine and Biotechnology, College of Medicine, Buddhist Tzu-Chi University, Hualien, Taiwan.
authors.forename: Meng-Jiun
authors.initials: MJ
authors.lastname: Lai
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Wen
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Lin
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Shyr
authors.forename: Py-Yu
authors.initials: PY
authors.lastname: Lin
authors.forename: Kuo-Liang
authors.initials: KL
authors.lastname: Yang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001853:Bone Marrow / Q000276:immunology; D016000:Cluster Analysis; D005787:Gene Frequency; D014644:Genetic Variation; D015234:HLA-A Antigens / Q000145:classification / Q000235:genetics*; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics*; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D025341:Principal Component Analysis; D012042:Registries; D013624:Taiwan; D014019:Tissue Donors
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen