title: Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.
abstract: A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.
authors.forename: Madan Kumar
authors.initials: MK
authors.lastname: Kharel
authors.forename: Pallab
authors.initials: P
authors.lastname: Pahari
authors.forename: Hui
authors.initials: H
authors.lastname: Lian
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rohr
mesh_terms: D000105:Acetyl Coenzyme A / Q000737:chemistry; D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008316:Malonyl Coenzyme A / Q000737:chemistry; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*; D013302:Streptomyces / Q000737:chemistry; D000095602:Angucyclines and Angucyclinones
chemical_list: D000105:Acetyl Coenzyme A; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D008316:Malonyl Coenzyme A; D048630:Polyketide Synthases; C003289:rabelomycin; D000095602:Angucyclines and Angucyclinones