title: Transverse myelitis and polymyositis associated with antiphospholipid antibody syndrome.
abstract: Antiphospholipid antibody syndrome (APS) has been widely recognized to be associated with various neurological complications. In addition to the classical notion of APS as a thrombotic disorder, APS has been suggested to be an autoinflammatory disease as well. We present a previously healthy 46-year-old man who concurrently developed transverse myelitis and polymyositis whose laboratory studies were significant for the elevated antiphospholipid antibodies such as anti-cardiolipin (CL)/beta2-glycoprotein I (beta 2GPI) antibody. This report further enhances the recognized clinical phenotypes of the neurological complications of APS and the understanding of its pathomechanism.
authors.affiliation: Department of Neurology, Tokushima University, Tokushima, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Mori
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nodera
authors.forename: Syunya
authors.initials: S
authors.lastname: Nakane
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
mesh_terms: D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000097:blood / Q000209:etiology / Q000276:immunology*; D009188:Myelitis, Transverse / Q000097:blood / Q000150:complications / Q000276:immunology*; D017285:Polymyositis / Q000097:blood / Q000150:complications / Q000276:immunology*; D053482:beta 2-Glycoprotein I / Q000097:blood*
chemical_list: D053482:beta 2-Glycoprotein I