title: Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 Tesla.
abstract: OBJECTIVE
  To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content.
  
  
  METHODS
  Twenty-three premenopausal women underwent breath-hold point-resolved single-voxel 1H-MRS of the liver followed by respiratory-gated 1H-MRS at 3 Tesla and CT slice through the liver. Interscan variability for 1H-MRS was assessed in 6 volunteers. Pearson correlation coefficients, Bland-Altman 95% limit of agreement, and concordance correlation coefficients were calculated.
  
  
  RESULTS
  There was a strong correlation between breath-hold and respiratory-gated 1H-MRS (r = 0.94, P < 0.0001; concordance correlation coefficient, 0.75). Using Bland-Altman analysis, all but 2 data points were within the limits of agreement. Both 1H-MRS techniques had low interscan variability. There was an inverse correlation of both 1H-MRS techniques with CT attenuation values of the liver.
  
  
  CONCLUSIONS
  Breath-hold 1H-MRS is a reliable method to measure hepatic lipid content at 3 Tesla. Breath-hold 1H-MRS of the liver provides data that closely correlates with that obtained from longer-duration respiratory-gated technique.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. mbredella@partners.org
authors.forename: Miriam A
authors.initials: MA
authors.lastname: Bredella
authors.forename: Reza Hosseini
authors.initials: RH
authors.lastname: Ghomi
authors.forename: Bijoy J
authors.initials: BJ
authors.lastname: Thomas
authors.forename: Hugue A
authors.initials: HA
authors.lastname: Ouellette
authors.forename: Dushyant V
authors.initials: DV
authors.lastname: Sahani
authors.forename: Karen K
authors.initials: KK
authors.lastname: Miller
authors.forename: Martin
authors.initials: M
authors.lastname: Torriani
mesh_terms: D000328:Adult; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed
chemical_list: D008055:Lipids