title: Enantioselective and regiodivergent copper-catalyzed conjugate addition of trialkylaluminium reagents to extended nitro-Michael acceptors.
abstract: The first highly enantioselective and regiodivergent conjugate addition of trialkylaluminium reagents to nitrodienes and nitroenynes is described. By a design of the substrate and a fine-tuning of the reaction conditions, it is possible to selectively form the 1,4- or 1,6-adduct. The same combination of catalyst, copper source, and a ferrocene-based phosphine ligand afforded enantioselectivities up to 95% and 91%, respectively.
authors.affiliation: Université de Genève, Département de chimie organique, 30 Quai Ernest Ansermet, 1211 Genève 4, Switzerland.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Tissot
authors.forename: Daniel
authors.initials: D
authors.lastname: Müller
authors.forename: Sébastien
authors.initials: S
authors.lastname: Belot
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis