title: Magnetic targeting in the impermeable microvessel with two-phase fluid model--non-Newtonian characteristics of blood.
abstract: The present investigation deals with finding the trajectories of the drug dosed magnetic carrier particle in a microvessel with two-phase fluid model which is subjected to the external magnetic field. The radius of the microvessel is divided into the endothelial glycocalyx layer in which the blood is assumed to obey Newtonian character and a core and plug regions where the blood obeys the non-Newtonian Herschel-Bulkley character which is suitable for the microvessel of radius 50 microm. The carrier particles, bound with nanoparticles and drug molecules are injected into the vascular system upstream from malignant tissue, and captured at the tumor site using a local applied magnetic field. The applied magnetic field is produced by a cylindrical magnet positioned outside the body and near the tumor position. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel are considered in the present problem. An algorithm is given to solve the system of coupled equations for trajectories of the carrier particle in the invasive case. The trajectories of the carrier particle are found for both invasive and noninvasive targeting systems. A comparison is made between the trajectories in these cases. Also, the present results are compared with the data available for the impermeable microvessel with single-phase fluid flow. Also, a prediction of the capture of therapeutic magnetic nanoparticle in the impermeable microvasculature is made for different radii, distances and volume fractions in both the invasive and noninvasive cases.
authors.affiliation: Department of Mathematics, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721 302, India.
authors.forename: Sachin
authors.initials: S
authors.lastname: Shaw
authors.forename: P V S N
authors.initials: PV
authors.lastname: Murthy
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D019276:Glycocalyx / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008280:Magnetics; D055806:Microvessels / Q000502:physiology*; D008954:Models, Biological; D053758:Nanoparticles
chemical_list: D000970:Antineoplastic Agents