title: Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis.
abstract: Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S(N)2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry.
authors.affiliation: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, MC 164-30, Pasadena, CA 91125, USA.
authors.forename: Corinne
authors.initials: C
authors.lastname: Baumgartner
authors.forename: Sandy
authors.initials: S
authors.lastname: Ma
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D011083:Polycyclic Compounds; C531521:cortistatin A