Cell migration driven by cooperative substrate deformation patterns.
Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.
Angelini
Thomas E
TE
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Hannezo
Edouard
E
Trepat
Xavier
X
Fredberg
Jeffrey J
JJ
Weitz
David A
DA
D000465:Algorithms; D000818:Animals; D002450:Cell Communication; D002452:Cell Count; D018929:Cell Culture Techniques; D002465:Cell Movement; D002478:Cells, Cultured; D003470:Culture Media; D004285:Dogs; D005110:Extracellular Space / Q000502:physiology*; D007668:Kidney; D013997:Time Factors
D003470:Culture Media