Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia.
Although a number of studies have found prospective memory (PM) impairment in patients with schizophrenia, very little is known about the PM performance in non-psychotic relatives of these patients. The current study aimed to explore the PM performance in non-psychotic first-degree relatives of these patients. Two groups of participants (26 non-psychotic first-degree relatives of schizophrenia patients and 26 healthy comparison participants) were administered three PM tasks (time-, event-, and activity-based) and a set of neurocognitive tests. Results showed that the relatives performed significantly worse than the comparisons on most indices of the PM tasks, with a similar pattern of impairment found in other neurocognitive measures. Together with findings from previous studies, results of the current study suggest that PM may be a potential endophenotype for schizophrenia.
Wang
Ya
Y
Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Chan
Raymond C K
RC
Cui
Jifang
J
Deng
Yongyu
Y
Huang
Jia
J
Li
Huijie
H
Yan
Chao
C
Xu
Ting
T
Ma
Zheng
Z
Hong
Xiaohong
X
Li
Zhanjiang
Z
Shi
Haisong
H
Shum
David
D
D000328:Adult; D000368:Aged; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D018709:Statistics, Nonparametric