Feline lectin activity is critical for the cellular entry of feline infectious peritonitis virus.
Feline infectious peritonitis is a lethal disease of felids caused by systemic infection with a feline coronavirus. Here, we report identification and analysis of the feline homologue to the human lectin DC-SIGN and show that it is a coreceptor for virulent strains of serotype 1 and serotype 2 feline coronaviruses.
Regan
Andrew D
AD
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
Ousterout
David G
DG
Whittaker
Gary R
GR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002415:Cats; D016000:Cluster Analysis; D016765:Coronavirus, Feline / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D053585:Virus Attachment; D053586:Virus Internalization
D037181:Lectins, C-Type; D011956:Receptors, Cell Surface