title: Asymmetric quadruple aminocatalytic domino reactions to fused carbocycles incorporating a spirooxindole motif.
abstract: The efficient assembly of hydroindane derivatives incorporating a spirooxindole motif was realized via a new three-component domino reaction of (E)-4-(1-methyl-2-oxoindolin-3-ylidene)-3-oxobutanoates and two molecules of alpha,beta-unsaturated aldehydes under quadruple iminium-enamine-iminium-enamine catalysis. The complex products bearing six contiguous stereogenic centers were obtained in excellent stereoselectivities (96->99% ee, >99% de).
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Jiang
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Jia
authors.forename: Xiang
authors.initials: X
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007189:Indans; D007211:Indoles; D013141:Spiro Compounds