title: Adaptive support ventilation versus conventional ventilation for total ventilatory support in acute respiratory failure.
abstract: OBJECTIVE
  To compare the short-term effects of adaptive support ventilation (ASV), an advanced closed-loop mode, with conventional volume or pressure-control ventilation in patients passively ventilated for acute respiratory failure.
  
  
  METHODS
  Prospective crossover interventional multicenter trial.
  
  
  METHODS
  Six European academic intensive care units.
  
  
  METHODS
  Eighty-eight patients in three groups: patients with no obvious lung disease (n = 22), restrictive lung disease (n = 36) or obstructive lung disease (n = 30).
  
  
  METHODS
  After measurements on conventional ventilation (CV) as set by the patients' clinicians, each patient was switched to ASV set to obtain the same minute ventilation as during CV (isoMV condition). If this resulted in a change in PaCO(2), the minute ventilation setting of ASV was readjusted to achieve the same PaCO(2) as in CV (isoCO(2) condition).
  
  
  RESULTS
  Compared with CV, PaCO(2) during ASV in isoMV condition and minute ventilation during ASV in isoCO(2) condition were slightly lower, with lower inspiratory work/minute performed by the ventilator (p < 0.01). Oxygenation and hemodynamics were unchanged. During ASV, respiratory rate was slightly lower and tidal volume (Vt) slightly greater (p < 0.01), especially in obstructed patients. During ASV there were different ventilatory patterns in the three groups, with lower Vt in patients with restrictive disease and prolonged expiratory time in obstructed patients, thus mimicking the clinicians' choices for setting CV. In three chronic obstructive pulmonary disease patients the resulting Vt was unacceptably high.
  
  
  CONCLUSIONS
  Comparison between ASV and CV resulted either in similarities or in minor differences. Except for excessive Vt in a few obstructed patients, all differences were in favor of ASV.
authors.affiliation: Anestesia e Rianimazione 2, Fondazione IRCCS Policlinico S Matteo, Vle Golgi 19, 27100 Pavia, Italy. g.iotti@smatteo.pv.it
authors.forename: Giorgio A
authors.initials: GA
authors.lastname: Iotti
authors.forename: Andrea
authors.initials: A
authors.lastname: Polito
authors.forename: Mirko
authors.initials: M
authors.lastname: Belliato
authors.forename: Daniela
authors.initials: D
authors.lastname: Pasero
authors.forename: Gaetan
authors.initials: G
authors.lastname: Beduneau
authors.forename: Marc
authors.initials: M
authors.lastname: Wysocki
authors.forename: Josef X
authors.initials: JX
authors.lastname: Brunner
authors.forename: Antonio
authors.initials: A
authors.lastname: Braschi
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
authors.forename: Jordi
authors.initials: J
authors.lastname: Mancebo
authors.forename: V Marco
authors.initials: VM
authors.lastname: Ranieri
authors.forename: Jean-Christophe M
authors.initials: JC
authors.lastname: Richard
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Slutsky
mesh_terms: D000208:Acute Disease; D000368:Aged; D018592:Cross-Over Studies; D005060:Europe; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy*