Artificial human tissues from cord and cord blood stem cells for multi-organ regenerative medicine: viable alternatives to animal in vitro toxicology.
New medicinal products and procedures must meet very strict safety criteria before being applied for use in humans. The laboratory procedures involved require the use of large numbers of animals each year. Furthermore, such investigations do not always give an accurate translation to the human setting. Here, we propose a viable alternative to animal testing, which uses novel technology featuring human cord and cord blood stem cells. With over 130 million children born each year, cord and cord blood remains the most widely available alternative to the use of animals or cadaveric human tissues for in vitro toxicology.
Jurga
Marcin
M
Parc Technologique de Lyon-Saint Priest, Woodstock Batiment Cedre 1, 97 Allee Alexandre Borodine, 69800 Saint Priest, France.
Forraz
Nico
N
McGuckin
Colin P
CP
D000826:Animal Testing Alternatives / Q000592:standards*; D000818:Animals; D001187:Artificial Organs; D004475:Ectoderm / Q000166:cytology / Q000502:physiology; D004707:Endoderm / Q000166:cytology / Q000502:physiology; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D007231:Infant, Newborn; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D014470:Umbilical Cord / Q000166:cytology / Q000276:immunology / Q000502:physiology*