title: Bone mineral density in HIV-infected women taking antiretroviral therapy: a systematic review.
abstract: There is a high prevalence of osteoporosis in HIV-infected patients. Initially described in HIV-positive men, studies have also demonstrated a high prevalence of osteoporosis in HIV-infected women. It would appear that antiretroviral therapy (ART) plays an important role in the pathogenesis of osteoporosis in HIV-infected patients, although little is known about its importance in relation to osteoporosis and fractures in HIV-positive women. The aim of this systematic review was to evaluate the frequency of bone loss, bone mineral density (BMD) and fractures in HIV-positive women taking ART or protease inhibitors (PI). After screening 597 citations from the databases of PubMed, EMBASE and Lilacs, five studies were selected for the review. A difference was demonstrated of over 3% in the BMD at the femoral neck of HIV-positive women taking PI/ART. No difference was registered in the BMD at the lumbar spine between users and non-users of PI/ART. The lack of studies has made it impossible to reach any conclusion regarding the occurrence of fractures.
authors.affiliation: Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil. ericohc@hotmail.com <ericohc@hotmail.com>
authors.forename: Erico Higino de
authors.initials: EH
authors.lastname: Carvalho
authors.forename: Thais
authors.initials: T
authors.lastname: Gelenske
authors.forename: Francisco
authors.initials: F
authors.lastname: Bandeira
authors.forename: Maria da Fátima Pessoa Militão de
authors.initials: Mda F
authors.lastname: Albuquerque
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D002986:Clinical Trials as Topic; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D010024:Osteoporosis / Q000139:chemically induced*
chemical_list: D019380:Anti-HIV Agents