title: Resin infiltration of caries lesions: an efficacy randomized trial.
abstract: Resin infiltration is an innovative approach to arrest progression of caries lesions. The aim of this randomized split-mouth placebo-controlled clinical trial was to assess whether resin infiltration of proximal lesions is more effective than non-operative measures alone with respect to the inhibition of caries progression. In 22 young adults, 29 pairs of interproximal lesions with radiological extension into the inner half of enamel or the outer third of dentin were randomly allocated to two treatment groups. In the test group, lesions were infiltrated (Icon, pre-product; DMG). A placebo treatment was performed in the control group. All participants received instructions for diet, flossing, and fluoridation. The primary outcome after 18 months was radiographic lesion progression (assessed by digital subtraction radiography). No unwanted effects could be observed. In the effect group, 2/27 lesions (7%) and in the control group 10/27 lesions (37%) showed progression (p = 0.021; McNemar). Infiltration of interproximal caries lesions is efficacious in reducing lesion progression.
authors.affiliation: Clinic for Conservative Dentistry and Periodontology, School for Dental Medicine, Christian-Albrechts-Universität zu Kiel, Arnold-Heller-Str. 3, Haus 26, 24105 Kiel, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Paris
authors.forename: W
authors.initials: W
authors.lastname: Hopfenmuller
authors.forename: H
authors.initials: H
authors.lastname: Meyer-Lueckel
mesh_terms: D000328:Adult; D003188:Composite Resins / Q000627:therapeutic use*; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000517:prevention & control*; D018450:Disease Progression; D005260:Female; D006801:Humans; D055115:Light-Curing of Dental Adhesives; D008297:Male; D011859:Radiography; D018709:Statistics, Nonparametric; D013382:Subtraction Technique; D055815:Young Adult
chemical_list: D003188:Composite Resins