NHC-iron-catalyzed aerobic oxidative aromatic esterification of aldehydes using boronic acids.
NHC-iron complexes prepared in situ very efficiently afforded benzoates via the aerobic oxidative aromatic esterification of aldehydes with boronic acids. This method uses equimolar amounts of both the aldehyde and the boronic acid allowing the preparation of benzoates in yields up to 97%.
Rosa
João N
JN
iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Reddy
R Sudarshan
RS
Candeias
Nuno R
NR
Cal
Pedro M S D
PM
Gois
Pedro M P
PM
D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D004951:Esterification; D005296:Ferrous Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000447:Aldehydes; D000577:Amides; D001565:Benzoates; D001897:Boronic Acids; D005296:Ferrous Compounds; C030011:carbene; D008697:Methane