Water extract of Houttuynia cordata Thunb. leaves exerts anti-obesity effects by inhibiting fatty acid and glycerol absorption.
Houttuynia cordata Thunb. is used in folk medicine for diuresis and detoxification. However, it has not yet been reported to have an anti-obesity effect. We found that the water extract of H. cordata leaves (WEH) inhibited the corn oil-induced increase in plasma triglyceride levels in mice. WEH also inhibited the oleic acid- and glycerol-induced increase in the levels of plasma nonesterified fatty acids and glycerol, respectively. Moreover, WEH had anti-obesity effects in mice with high-fat-diet-induced obesity. Therefore, WEH may be able to prevent or reduce obesity induced by a high-fat diet.
Miyata
Mitsuyoshi
M
Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Japan.
Koyama
Tomoyuki
T
Yazawa
Kazunaga
K
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005260:Female; D005990:Glycerol / Q000097:blood / Q000378:metabolism*; D052859:Houttuynia; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051379:Mice; D009765:Obesity / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D014867:Water
D004365:Drugs, Chinese Herbal; D005227:Fatty Acids; C442781:Houttuynia cordata extract; D014280:Triglycerides; D014867:Water; D005990:Glycerol