title: Pre-operative management is associated with low rate of post-operative morbidity in penetrating Crohn's disease.
abstract: BACKGROUND
  Ileocaecal resection for penetrating Crohn's disease is still challenging with a high rate of post-operative morbidity and faecal diversion.
  
  
  OBJECTIVE
  To report retrospectively the results of pre-operative management for penetrating Crohn's disease focusing on the rate of post-operative major morbidities and need for faecal diversion.
  
  
  METHODS
  Between 1997 and 2007, 78 patients with penetrating Crohn's disease underwent a first ileocaecal resection after a pre-operative management consisting in bowel rest, nutritional therapy, intravenous antibiotics, weaning off steroids and immunosuppressors, and drainage of abscesses when appropriate.
  
  
  RESULTS
  Resection was performed for terminal ileitis associated with (n = 41), abscesses (n = 37) or both (n = 5). A pre-operative nutritional therapy was performed in 50 patients (68%) for 23 days (range, 7-69 days) along with a weaning off steroids and immunosuppressors. A diverting stoma was performed for six patients (7.7%). There was no post-operative death. Post-operative complications were classified as minor in 10 patients (12.8%), and major in four patients (5%). Overall, the post-operative course was uneventful in 58 patients (74%).
  
  
  CONCLUSIONS
  Pre-operative management for penetrating Crohn's disease allowed ileocaecal resection with low rates of post-operative morbidity and faecal diversion.
authors.affiliation: Department of Digestive Surgery and Transplantation, Univ Lille Nord de France, CHU Lille, France. p-zerbib@chru-lille.fr
authors.forename: P
authors.initials: P
authors.lastname: Zerbib
authors.forename: D
authors.initials: D
authors.lastname: Koriche
authors.forename: S
authors.initials: S
authors.lastname: Truant
authors.forename: A F
authors.initials: AF
authors.lastname: Bouras
authors.forename: G
authors.initials: G
authors.lastname: Vernier-Massouille
authors.forename: D
authors.initials: D
authors.lastname: Seguy
authors.forename: F R
authors.initials: FR
authors.lastname: Pruvot
authors.forename: A
authors.initials: A
authors.lastname: Cortot
authors.forename: J F
authors.initials: JF
authors.lastname: Colombel
mesh_terms: D000038:Abscess / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D003424:Crohn Disease / Q000601:surgery*; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000601:surgery*; D011300:Preoperative Care / Q000009:adverse effects*; D012189:Retrospective Studies; D055815:Young Adult