title: In-vivo measurement of cortical morphology: means and meanings.
abstract: OBJECTIVE
  Study of the variability of the cortical mantle thickness is now a key issue in neuroimaging. Here we describe a more recent trend aiming at the study of the variability of the cortical folding morphology.
  
  
  RESULTS
  Computerized three-dimensional versions of gyrification index and other morphometric features dedicated to the folding patterns are modified in psychiatric syndromes and neurologic disorders. These observations provide new insights into the mechanisms involved in abnormal development or abnormal aging.
  
  
  CONCLUSIONS
  Quantification of the folding morphology will contribute to the global endeavor aiming at building biomarkers from neuroimaging data, with a specific focus on developmental diseases.
authors.affiliation: LNAO, NeuroSpin, I2BM, CEA, Gif-sur-Yvette, France. jfmangin@cea.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
authors.forename: Eric
authors.initials: E
authors.lastname: Jouvent
authors.forename: Arnaud
authors.initials: A
authors.lastname: Cachia
mesh_terms: D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D003198:Computer Simulation / Q000639:trends*; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D001523:Mental Disorders / Q000473:pathology / Q000503:physiopathology; D009421:Nervous System Malformations / Q000473:pathology / Q000503:physiopathology