title: Preoperative platelet response to collagen is associated with myocardial injury after off-pump coronary bypass graft in patients taking aspirin.
abstract: BACKGROUND
  We hypothesized that, even in patients taking aspirin, the variance of preoperative platelet response to collagen might be associated with myocardial injury during coronary artery bypass graft (CABG) surgery. Therefore, we evaluated the relationship between preoperative whole-blood aggregometry (WBA) by collagen and the postoperative myocardial injuries.
  
  
  METHODS
  For 44 patients who were scheduled for elective off-pump CABG and taking aspirin, WBA was measured by the impedance method in the presence of collagen (2 mg/ml or 5 mg/ml) as stimulatory agents. After CABG, myocardial injury was evaluated by analysis of the creatine kinase (CK), creatine kinase-MB (CK-MB), and lactate dehydrogenase (LD), and by electrocardiography.
  
  
  RESULTS
  High response group (n = 13) on preoperative WBA with collagen (2 and 5 mg/ml) showed significantly higher postoperative cardiac enzyme levels (CK, CK-MB and LD) than those of low response group (n = 31).
  
  
  CONCLUSIONS
  In patients who take aspirin and undergoing off-pump CABG, the preoperative platelet response to collagen is correlated with postoperative myocardial injury.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Deok Man
authors.initials: DM
authors.lastname: Hong
authors.forename: Yun Seok
authors.initials: YS
authors.lastname: Jeon
authors.forename: Jun Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Tae Wan
authors.initials: TW
authors.lastname: Lim
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Lim
authors.forename: Jae Hyon
authors.initials: JH
authors.lastname: Bahk
authors.forename: Ki Bong
authors.initials: KB
authors.lastname: Kim
authors.forename: Il Jae
authors.initials: IJ
authors.lastname: Kim