title: TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand.
abstract: OBJECTIVE
  To investigate association of TIM1 sequence variations with HIV/AIDS progression.
  
  
  BACKGROUND
  : HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response.
  
  
  METHODS
  We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplotypes. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated.
  
  
  RESULTS
  Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4 cell count (P = 0.06) and lower proportion of AIDS-related symptoms (P = 0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P = 0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1.
  
  
  CONCLUSIONS
  TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females.
authors.affiliation: National institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Nuanjun
authors.initials: N
authors.lastname: Wichukchinda
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Nongluk
authors.initials: N
authors.lastname: Saipradit
authors.forename: Emi E
authors.initials: EE
authors.lastname: Nakayama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohtani
authors.forename: Archawin
authors.initials: A
authors.lastname: Rojanawiwat
authors.forename: Panita
authors.initials: P
authors.lastname: Pathipvanich
authors.forename: Koya
authors.initials: K
authors.lastname: Ariyoshi
authors.forename: Pathom
authors.initials: P
authors.lastname: Sawanpanyalert
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Shioda
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015497:HIV-1; D006239:Haplotypes; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D011991:Receptors, Virus / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis; D019562:Viral Load
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus