[Dynamika uvolnování neomycinu a linkomycinu in vitro ze sklokeramických materiálů].
The dynamics of release of neomycin and lincomycin from glass-ceramic materials BAS-0, BAS-HA and BAS-R in the form of cullet was monitored in vitro. After the saturation by individual antibiotics the glass-ceramic samples were overlaid with fibrin glue and after it became solid they were covered with buffered physiological solution. In the samples taken at planned intervals in the course of 2 months eluted ATB quantity was determined by agar well method. Release of ATB from glass-ceramics proceeded in two phases, elution slowed down in most cases after 6 hours. With the use of composites there occurred another slowing down of the speed of elution after another 48 hours. Of the total eluted quantity of ATB 50 % was released in neomycine in 2-4 hours, in lincomycin in 6 hours. After 48 hours only small quantities of ATB were eluted, however, they were still detected at the end of the monitored period. The total released quantity of ATB was influenced by the type of the material used, or to a lesser extent, also by size of its particules and in case of composites by the proportion of their components. Key words: bioactive, porous glass-ceramics, separation of antibiotics from the carrier, Beriplast fibrin glue.
Hanovcová
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I
Ustav a katedra mikrobiologie LF UK, Hradec Králové
Urban
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K