title: Compounds from Acorus tatarinowii: determination of absolute configuration by quantum computations and cAMP regulation activity.
abstract: A new cadinane-type sesquiterpenoid, tatarinowin A (1), two phenylpropanoids, tatarinoids A (2) and B (3), and a trinorlignan, tatarinoid C (4), along with 15 known compounds including two pairs of mixtures were isolated from the rhizome of Acorus tatarinowii. The absolute configurations of 1-4 were established by computation of specific rotation values. The isolated compounds were evaluated for their cAMP regulatory activity by the AlphaScreen assay.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Tong
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Wu
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Huang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D029023:Acorus / Q000737:chemistry*; D000242:Cyclic AMP / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans; D010666:Phenylpropionates; D012717:Sesquiterpenes; D000242:Cyclic AMP