title: Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care.
abstract: Critically ill patients are frequently prescribed sedatives and analgesics to ensure patient safety, to relieve pain and anxiety, to reduce stress and oxygen consumption, and to prevent patient ventilator dysynchrony. Recent studies have revealed that these medications themselves contribute to worsening clinical outcomes. An evidence-based organizational approach referred to as the ABCDE bundle (Awakening and Breathing Coordination of daily sedation and ventilator removal trials; Choice of sedative or analgesic exposure; Delirium monitoring and management; and Early mobility and Exercise) is presented in this commentary.
authors.affiliation: Anesthesiology Service, VA TN Valley Health Care System, 1310 24th Ave South, Nashville 37212, USA. pratik.pandharipande@vanderbilt.edu
authors.forename: Pratik
authors.initials: P
authors.lastname: Pandharipande
authors.forename: Arna
authors.initials: A
authors.lastname: Banerjee
authors.forename: Stuart
authors.initials: S
authors.lastname: McGrane
authors.forename: E Wesley
authors.initials: EW
authors.lastname: Ely
mesh_terms: D000075202:Contraindications; D003422:Critical Care / Q000379:methods*; D055317:Evidence-Based Practice; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000627:therapeutic use*; D007362:Intensive Care Units; D017146:Models, Organizational; D012121:Respiration, Artificial
chemical_list: D006993:Hypnotics and Sedatives