Structure, corrosion behavior and mechanical property of a novel poly(vinyl alcohol) composite in simulated body fluid.
The data for long-term drug-delivery systems are scarce compared to the short-term systems because the required research efforts are more time-consuming. In this study, we report a novel cross-linked composite based on poly(vinyl alcohol) (PVA) containing cupric ions for long-term delivery, which is helpful for contraception and trace element balance in the human body. The composition, corrosion products, crystal structure, chemical structure and mechanical stability of the composite, after being immersed in simulated body fluid (SBF) for one year, were studied by X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and mechanical testing. The results show that no other new elements, such as P, Cl and Ca, appear on the surface of the composite and no Cu(2)O was formed after immersion in SBF for one year. The effectiveness of copper can be greatly improved and the side-effects caused by these compounds might also be eliminated. Furthermore, this novel composite exhibits long-term mechanical stability in SBF. The present in vitro long-term data suggest that this novel copper-containing composite may serve as a substitute for conventional materials of copper-containing intrauterine devices (Cu-IUDs) and as a carrier for controlled-release material in a variety of other applications.
Li
Juan
J
State Key Laboratory of Mould Technology, Institute of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China.
Suo
Jinping
J
Zou
Peng
P
Jia
Lintao
L
Wang
Shifang
S
D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D003343:Corrosion; D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems; D006801:Humans; D007434:Intrauterine Devices; D008422:Materials Testing; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003300:Copper; D011142:Polyvinyl Alcohol