title: Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa.
abstract: OBJECTIVE
  The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN).
  
  
  METHODS
  Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-alpha and interleukin (IL)-1beta), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form.
  
  
  RESULTS
  BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (P<0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (P<0.05 for both).
  
  
  CONCLUSIONS
  Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.
authors.affiliation: Department of Nutrition, Metabolic diseases, Endocrinology, University of Aix-Marseille 2, 'La Timone' Hospital, Marseille, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Nogueira
authors.forename: M
authors.initials: M
authors.lastname: Maraninchi
authors.forename: A-M
authors.initials: AM
authors.lastname: Lorec
authors.forename: A B-L
authors.initials: AB
authors.lastname: Corroller
authors.forename: A
authors.initials: A
authors.lastname: Nicolay
authors.forename: J
authors.initials: J
authors.lastname: Gaudart
authors.forename: H
authors.initials: H
authors.lastname: Portugal
authors.forename: R
authors.initials: R
authors.lastname: Barone
authors.forename: B
authors.initials: B
authors.lastname: Vialettes
authors.forename: R
authors.initials: R
authors.lastname: Valéro
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D052018:Bulimia Nervosa / Q000097:blood*; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000097:blood*; D020738:Leptin / Q000097:blood*; D009043:Motor Activity; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D020738:Leptin; D052243:Resistin