title: Highly oxygenated guaianolides from Artemisia dubia.
abstract: Investigation of a Chinese folk medicine, Artemisia dubia (syn. Artemisia subdigitata), has resulted in the isolation of eight new guaianolides (artemdubolides A-H, 1-8), and nineteen known sesquiterpene lactones. Their structures were elucidated primarily on the basis of spectroscopic methods, including extensive 2D NMR experiments. The cytotoxic activities of compounds 1-8 were evaluated against A549 (human lung adenocarcinoma), Colo205 (human colon carcinoma), HepG2 (human hepatoma), and MDA-MB-435 (human melanoma) cell lines. Compounds 2 and 5 showed weak cell growth inhibition of Colo205 and MDA-MB-435 cells.
authors.affiliation: Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Zheng-Sheng
authors.initials: ZS
authors.lastname: Huang
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Chu-Mei
authors.initials: CM
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Tang
authors.forename: Da-Sen
authors.initials: DS
authors.lastname: Huang
authors.forename: Tai-Fa
authors.initials: TF
authors.lastname: Song
authors.forename: Long-Hai
authors.initials: LH
authors.lastname: Lu
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Gao
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D019306:Artemisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane