Synthesis of densely substituted trans-configured 4-acylated piperidine-2,4-diones as 3:1 adducts of imines and ketenes.
An operationally simple method is described to form densely substituted diastereomerically pure trans-configured and potentially biologically interesting 5,6-dihydropyridone derivatives as 3:1 adducts of ketenes formed in situ from acyl bromides and aromatic imines.
Cabrera
José
J
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany.
Hellmuth
Tina
T
Peters
René
R