title: The mouse retina as an angiogenesis model.
abstract: The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse retina and a discussion of some of the most widely used vascular disease models. From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stahl
authors.forename: Kip M
authors.initials: KM
authors.lastname: Connor
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Sapieha
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Dennison
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Krah
authors.forename: Molly R
authors.initials: MR
authors.lastname: Seaward
authors.forename: Keirnan L
authors.initials: KL
authors.lastname: Willett
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Aderman
authors.forename: Karen I
authors.initials: KI
authors.lastname: Guerin
authors.forename: Jing
authors.initials: J
authors.lastname: Hua
authors.forename: Chatarina
authors.initials: C
authors.lastname: Löfqvist
authors.forename: Ann
authors.initials: A
authors.lastname: Hellström
authors.forename: Lois E H
authors.initials: LE
authors.lastname: Smith
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D018919:Neovascularization, Physiologic / Q000502:physiology*; D015861:Retinal Neovascularization / Q000503:physiopathology*; D012171:Retinal Vessels / Q000502:physiology*