title: XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: a meta-analysis.
abstract: Several studies have investigated the associations between X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and the susceptibility to lung cancer and bladder cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 22 case control studies, including 2976 cases and 4495 controls for lung cancer, and 3445 cases and 4599 controls for bladder cancer, met the inclusion criteria and were selected. Overall, there was no evidence showing a significant association between XRCC3 Thr241Met polymorphism and lung cancer risk. Furthermore, the results for bladder cancer showed that significant decreased risk was found for the additive model (odds ratio [OR] = 0.959, 95% confidence interval [CI], 0.924-0.996) and dominant model (OR = 0.982, 95% CI, 0.963-1.000) but not for the recessive model (OR = 0.958, 95% CI, 0.905-1.014). In summary, our meta-analysis indicates that XRCC3 Thr241Met polymorphism may be weakly associated with the risk of bladder cancer. (Cancer Sci 2010).
authors.affiliation: Harbin Medical University, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Sun
authors.forename: Yuandong
authors.initials: Y
authors.lastname: Qiao
authors.forename: Xuelong
authors.initials: X
authors.lastname: Zhang
authors.forename: Lidan
authors.initials: L
authors.lastname: Xu
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Jia
authors.forename: Donglin
authors.initials: D
authors.lastname: Sun
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.forename: An
authors.initials: A
authors.lastname: Liu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Songbin
authors.initials: S
authors.lastname: Fu
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3