Towards molecular systems biology of gene transcription and regulation.
Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.
Cramer
Patrick
P
Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig Maximilians University, Gene Center, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany. cramer@LMB.uni-muenchen.de
D005786:Gene Expression Regulation; D008958:Models, Molecular; D049490:Systems Biology; D014158:Transcription, Genetic