Complete genome constellation of a caprine group A rotavirus strain reveals common evolution with ruminant and human rotavirus strains.
This study reports the first complete genome sequence of a caprine group A rotavirus (GAR) strain, GO34. The VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes of strain GO34, detected in Bangladesh, were assigned to the G6-P[1]-I2-R2-C2-M2-A11-N2-T6-E2-H3 genotypes, respectively. Strain GO34 was closely related to the VP4, VP6-7 and NSP4-5 genes of bovine GARs and the NSP1 gene of GO34 to an ovine GAR. Strain GO34 shared low nucleotide sequence identities (<90 %) with VP2-3 genes of other GARs, and was equally related to NSP3 genes of human, ruminant and camelid strains. The VP1, VP6 and NSP2 genes of strain GO34 also exhibited a close genetic relatedness to human G2, G6, G8 and G12 DS-1-like GARs, whereas the NSP1 of GO34 was also closely related to human G6P[14] strains. All these findings point to a common evolutionary origin of GO34 and bovine, ovine, antelope, guanaco and human G6P[14] GARs, although phylogenetically GO34 is not particularly closely related to any other rotavirus strains known to date.
Ghosh
Souvik
S
Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan. souvikrota@gmail.com
Alam
Mohammed Mahbub
MM
Ahmed
Muzahed Uddin
MU
Talukdar
Rafiqul Islam
RI
Paul
Shyamal Kumar
SK
Kobayashi
Nobumichi
N
D000818:Animals; D001459:Bangladesh; D002417:Cattle; D019143:Evolution, Molecular; D016679:Genome, Viral; D015511:Goat Diseases / Q000821:virology; D006041:Goats / Q000821:virology*; D006801:Humans; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000662:veterinary / Q000821:virology; D012418:Ruminants / Q000821:virology; D013045:Species Specificity; D017361:Viral Nonstructural Proteins / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics
D017361:Viral Nonstructural Proteins; D015678:Viral Structural Proteins