title: Cell migration driven by cooperative substrate deformation patterns.
abstract: Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.
authors.affiliation: School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Angelini
authors.forename: Edouard
authors.initials: E
authors.lastname: Hannezo
authors.forename: Xavier
authors.initials: X
authors.lastname: Trepat
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Fredberg
authors.forename: David A
authors.initials: DA
authors.lastname: Weitz
mesh_terms: D000465:Algorithms; D000818:Animals; D002450:Cell Communication; D002452:Cell Count; D018929:Cell Culture Techniques; D002465:Cell Movement; D002478:Cells, Cultured; D003470:Culture Media; D004285:Dogs; D005110:Extracellular Space / Q000502:physiology*; D007668:Kidney; D013997:Time Factors
chemical_list: D003470:Culture Media