title: Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption.
abstract: Advanced glycation endproducts (AGEs) are a group of complex and heterogeneous compounds formed from nonenzymatic reactions. The accumulation of AGEs in vivo has been implicated as a major pathogenic process in diabetic complications and other health disorders, such as atherosclerosis and Alzheimer's disease, and normal aging. In this study, we investigate the inhibitory effects of cinnamon bark proanthocyanidins, catechin, epicatechin, and procyanidin B2 on the formation of specific AGE representatives including pentosidine, N(epsilon)-(carboxymethyl)lysine (CML), and methylglyoxal (MGO) derived AGEs. These compounds displayed obvious inhibitory effects on these specific AGEs, which are largely attributed to both their antioxidant activities and carbonyl scavenging capacities. Meanwhile, in terms of their potent MGO scavenging capacities, effects of these proanthocyanidins on insulin signaling pathways interfered by MGO were evaluated in 3T3-L1 adipocytes. According to the results, proanthocyanidins exerted protective effects on glucose consumption impaired by MGO in 3T3-L1 fat cells.
authors.affiliation: School of Biological Sciences, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Peng
authors.forename: Jinyu
authors.initials: J
authors.lastname: Ma
authors.forename: Jianfei
authors.initials: J
authors.lastname: Chao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Sun
authors.forename: Raymond Chuen-Chung
authors.initials: RC
authors.lastname: Chang
authors.forename: Iris
authors.initials: I
authors.lastname: Tse
authors.forename: Edmund T S
authors.initials: ET
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Mingfu
authors.initials: M
authors.lastname: Wang
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D005947:Glucose / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation / Q000187:drug effects; D051379:Mice; D008954:Models, Biological; D041681:NIH 3T3 Cells; D010936:Plant Extracts / Q000494:pharmacology*; D044945:Proanthocyanidins / Q000494:pharmacology*; D011765:Pyruvaldehyde / Q000494:pharmacology*
chemical_list: D017127:Glycation End Products, Advanced; D010936:Plant Extracts; D044945:Proanthocyanidins; D011765:Pyruvaldehyde; D005947:Glucose