title: Xestosaprols from the Indonesian marine sponge Xestospongia sp.
abstract: Eight pentacyclic compounds, xestosaprols F-M (1-8), were isolated from a marine sponge belonging to the genus Xestospongia. The structures of these new compounds were determined on the basis of extensive analyses of NMR experiments and mass spectrometric measurements. These compounds inhibited the aspartic protease BACE1 at moderate levels in a dose-dependent manner.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822.
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Dai
authors.forename: Analia
authors.initials: A
authors.lastname: Sorribas
authors.forename: Wesley Y
authors.initials: WY
authors.lastname: Yoshida
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly
authors.forename: Philip G
authors.initials: PG
authors.lastname: Williams
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007214:Indonesia; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human