Serum cholesterol concentration associated with aspirin esterase activity in older people: preliminary data.
OBJECTIVE
Metabolism of aspirin (acetylsalicylic acid), commonly used in older people for the prevention of cardiovascular disease, is important to the effectiveness of this drug. Whereas part of aspirin hydrolysis occurs in blood, there is a paucity of information in regards to circulating aspirin esterase activity in various physiological and pathological conditions. High aspirin esterase activity, corresponding to faster aspirin hydrolysis (thus aspirin non-responsiveness), may occur in cardiovascular disease-prone states. The objective of this study was to investigate the effects of cardio-metabolic variables such as cholesterol on serum aspirin esterase activity in older people who participated in an intervention study on physical activity.


METHODS
A total of 18 non-medicated subjects (7 men/11 women, mean age 67.8 years, body mass index = 23.4 +/- 3.3 kg/m(2)), who completed a 3-month interventional program for a mild-to-moderate increase in physical activity, were analyzed. The body mass index, plasma glucose, serum total cholesterol and aspirin esterase activity were measured in the pre- and post-interventional phases of the study.


RESULTS
During the interventional period, the changes in aspirin esterase activity correlated significantly and positively with those of total cholesterol concentrations (r = 0.542, P = 0.020; beta = 0.609, P = 0.035 in a multiple linear regression analysis after adjusting for all the measured variables).


CONCLUSIONS
The results suggest that cholesterol metabolism alterations may be associated with aspirin metabolism in older people.
Kotani
Kazuhiko
K
Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp
Caccavello
Russell
R
Hermo
Ricardo
R
Yamada
Toshiyuki
T
Taniguchi
Nobuyuki
N
Gugliucci
Alejandro
A
D000368:Aged; D001241:Aspirin; D001774:Blood Chemical Analysis; D001823:Body Composition; D015992:Body Mass Index; D002265:Carboxylic Ester Hydrolases; D002318:Cardiovascular Diseases / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D006868:Hydrolysis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis
D008078:Cholesterol, LDL; D002784:Cholesterol; D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase; D001241:Aspirin