title: [Correction of intracranial hypertension syndrome using hyperosmolar solutions in patients with severe brain damage (multicenter randomized clinical study)].
abstract: The paper presents the results of a muticenter study of the effect of 3 hyperosmolar solutions (15% mannitol solution, 10% sodium chloride solution, and the combined solution HyperHAES containing 7.2% sodium chloride and hydroxyethyl starch 200/0.5) on the value of intracranial pressure (ICP) (invasive ICP monitoring) and systemic hemodynamic parameters (PiCCOplus) in 94 clinical cases of intracranial hypertension (ICP more than 20 mm Hg) in 25 patients with acute cerebral pathology (severe brain injury, aneurysmatic subarachnoid hemorrhage). Intravenous infusion of the solutions was found to induce a reduction in ICP; however, this was most pronounced (by 30-40%) and longer (up to 4 hours) when HyperHAES solution was used. This solution produced not only an osmotic, but also hemodynamic effect.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Polushin
authors.forename: V V
authors.initials: VV
authors.lastname: Krylov
authors.forename: D V
authors.initials: DV
authors.lastname: Svistov
authors.forename: A A
authors.initials: AA
authors.lastname: Belkin
authors.forename: S S
authors.initials: SS
authors.lastname: Petrikov
authors.forename: A V
authors.initials: AV
authors.lastname: Shchegolev
authors.forename: I N
authors.initials: IN
authors.lastname: Leĭderman
authors.forename: V I
authors.initials: VI
authors.lastname: Shatalov
authors.forename: A M
authors.initials: AM
authors.lastname: Alasheev
authors.forename: M V
authors.initials: MV
authors.lastname: Golikov
authors.forename: Kh T
authors.initials: KhT
authors.lastname: Guseĭnova
authors.forename: E N
authors.initials: EN
authors.lastname: Rudnik
authors.forename: A S
authors.initials: AS
authors.lastname: Soldatov
authors.forename: A A
authors.initials: AA
authors.lastname: Solodov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Titova
mesh_terms: D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D015600:Glasgow Coma Scale; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006982:Hypertonic Solutions / Q000737:chemistry / Q000627:therapeutic use*; D019586:Intracranial Hypertension / Q000209:etiology / Q000628:therapy*; D007427:Intracranial Pressure / Q000187:drug effects*; D009994:Osmolar Concentration; D012426:Russia; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D006982:Hypertonic Solutions