title: Executive and behavioral deficits share common neural substrates in frontotemporal lobar degeneration - a pilot FDG-PET study.
abstract: Behavioral and executive dysfunctions are typical symptoms of frontotemporal lobar degeneration, associated with its subtypes frontotemporal and semantic dementia. Although both functions depend on the frontal lobes, no study has yet compared their neural correlates in frontotemporal lobar degeneration. Accordingly, we correlated clinical scores of behavioral and executive deficits with glucose utilization as measured by [(18)F]fluorodeoxyglucose positron emission tomography in 17 patients with frontotemporal lobar degeneration and 9 age- and sex-matched control subjects. Impairment in executive functions was measured by the Behavioral Assessment of the Dysexecutive Syndrome, a modified Stroop paradigm and/or the Tower of Toronto Test. Behavioral deficits were examined with the Neuropsychiatric Inventory. Executive dysfunction was correlated with diminished glucose utilization in frontomedial and frontolateral cortices. Brain regions included the anterior cingulate and midcingulate gyri, anterior medial frontal cortex, and left frontolateral cortex. Behavioral deficits were associated with mainly frontomedial networks, particularly the anterior medial frontal cortex, gyrus rectus, and area subcallosa. Our pilot study reveals partially overlapping neural correlates of executive and behavioral dysfunction in frontotemporal lobar degeneration. The results suggest that some behavioral deficits, namely disinhibition and appetite and eating abnormalities, are particularly related to executive dysfunction. This hypothesis might be further explored in studies involving larger patient groups.
authors.affiliation: Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Karolina A
authors.initials: KA
authors.lastname: Raczka
authors.forename: Georg
authors.initials: G
authors.lastname: Becker
authors.forename: Anita
authors.initials: A
authors.lastname: Seese
authors.forename: Stefan
authors.initials: S
authors.lastname: Frisch
authors.forename: Sandra
authors.initials: S
authors.lastname: Heiner
authors.forename: Anke
authors.initials: A
authors.lastname: Marschhauser
authors.forename: Henryk
authors.initials: H
authors.lastname: Barthel
authors.forename: Rainer
authors.initials: R
authors.lastname: Scheid
authors.forename: Osama
authors.initials: O
authors.lastname: Sabri
authors.forename: Matthias L
authors.initials: ML
authors.lastname: Schroeter
mesh_terms: D000368:Aged; D001526:Behavioral Symptoms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D057174:Frontotemporal Lobar Degeneration / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods; D013223:Statistics as Topic
chemical_list: D019788:Fluorodeoxyglucose F18