title: Testosterone, androgen receptor gene CAG repeat length, mood and behaviour in adolescent males.
abstract: OBJECTIVE
  Androgen activity has been implicated in a range of traits and behaviours that have well-documented sex differences. However, the results of the studies on the relationship between testosterone and these traits and behaviours are inconsistent. This study has analyzed i) whether CAG repeat length, a presumed modulator of androgen receptor sensitivity, is associated with sex-dimorphic traits and behaviours (aggressive and non-aggressive risk-taking (ART and NART), dominance, depressive symptoms and self-esteem), and ii) whether CAG repeat length interacts with free testosterone (FT) with respect to these traits and behaviours.
  
  
  METHODS
  Data obtained from a group of adolescent boys (n=301; mean age: 14.4 years) were analyzed using multivariate general linear modelling (SPSS, Chicago, IL, USA 15.0).
  
  
  RESULTS
  We found no direct correlation between CAG repeat length and dependent variables. We found significant interactions between CAG repeat length and testosterone, indicating that FT was more positively related to ART and NART with a shorter repeat length, and that an inverse association of FT with depressive symptoms and a positive association with self-esteem were stronger in boys with a longer CAG repeat length.
  
  
  CONCLUSIONS
  Our findings indicate the importance of studying FT and CAG repeat length simultaneously with respect to sex-dimorphic traits, taking into account the possible interactions between the two.
authors.affiliation: Department of Sociology, University of Ghent, Ghent, Belgium. hans.vermeersch@ugent.be
authors.forename: Hans
authors.initials: H
authors.lastname: Vermeersch
authors.forename: Guy
authors.initials: G
authors.lastname: T'Sjoen
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Kaufman
authors.forename: John
authors.initials: J
authors.lastname: Vincke
authors.forename: Mieke
authors.initials: M
authors.lastname: Van Houtte
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000502:physiology*; D000339:Affect / Q000502:physiology*; D000374:Aggression / Q000502:physiology; D000704:Analysis of Variance; D003863:Depression / Q000235:genetics; D006801:Humans; D007118:Immunoassay; D008297:Male; D015999:Multivariate Analysis; D011581:Psychological Tests; D011944:Receptors, Androgen / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012309:Risk-Taking; D020377:Self Efficacy; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood* / Q000235:genetics; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D011944:Receptors, Androgen; D013739:Testosterone