title: Impact of thermodynamic principles in systems biology.
abstract: It is shown that properties of biological systems which are relevant for systems biology motivated mathematical modelling are strongly shaped by general thermodynamic principles such as osmotic limit, Gibbs energy dissipation, near equilibria and thermodynamic driving force. Each of these aspects will be demonstrated both theoretically and experimentally.
authors.affiliation: Department Biotechnology, Bioprocess technology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands, j.j.heijnen@tudelft.nl.
authors.forename: J J
authors.initials: JJ
authors.lastname: Heijnen
mesh_terms: D003198:Computer Simulation; D004734:Energy Metabolism / Q000502:physiology*; D064688:Metabolic Flux Analysis / Q000379:methods*; D055442:Metabolome / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology / Q000379:methods*; D013816:Thermodynamics