Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities.
Bolognesi
Maria Laura
ML
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy. marialaura.bolognesi@unibo.it
Bartolini
Manuela
M
Mancini
Francesca
F
Chiriano
Gianpaolo
G
Ceccarini
Luisa
L
Rosini
Michela
M
Milelli
Andrea
A
Tumiatti
Vincenzo
V
Andrisano
Vincenza
V
Melchiorre
Carlo
C
D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D001665:Binding Sites; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D008024:Ligands; D013619:Tacrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
C122128:1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine; D000682:Amyloid; D002800:Cholinesterase Inhibitors; D008024:Ligands; D013619:Tacrine; D000110:Acetylcholinesterase; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human