title: Effects of equal daily doses delivered by different power densities of low-level laser therapy at 670 nm on open skin wound healing in normal and corticosteroid-treated rats: a brief report.
abstract: The optimal parameters for low-level laser therapy (LLLT) for wound healing are still open to discussion. Hence, our study was aimed at comparing the effects of different power densities of LLLT at 670 nm in rats. Four round full-thickness skin wounds were placed on the backs of 16 rats which were divided into two groups (non-steroid and steroid-treated). Three wounds were stimulated daily with a diode laser (daily dose 5 J/cm(2)) at different power densities (5, 15 and 40 mW/cm(2), respectively), and the fourth wound served as a control. Six days after surgery all animals were killed and samples removed for histological evaluation. Significant acceleration of fibroblast proliferation and new vessel formation was observed in wounds treated at the selected power densities. No significant differences were found in corticosteroid-treated rats. In conclusion, LLLT with the methodology used improved wound healing in non-steroid rats, but was not effective after corticosteroid-treatment.
authors.affiliation: Department of Medical Biophysics, Pavol Jozef Safárik University, 040 11, Kosice, Slovak Republic.
authors.forename: Kamila
authors.initials: K
authors.lastname: Lacjaková
authors.forename: Nikita
authors.initials: N
authors.lastname: Bobrov
authors.forename: Martina
authors.initials: M
authors.lastname: Poláková
authors.forename: Martin
authors.initials: M
authors.lastname: Slezák
authors.forename: Martina
authors.initials: M
authors.lastname: Vidová
authors.forename: Tomás
authors.initials: T
authors.lastname: Vasilenko
authors.forename: Martin
authors.initials: M
authors.lastname: Novotný
authors.forename: Frantisek
authors.initials: F
authors.lastname: Longauer
authors.forename: L'udovít
authors.initials: L
authors.lastname: Lenhardt
authors.forename: Juraj
authors.initials: J
authors.lastname: Bober
authors.forename: Mikulás
authors.initials: M
authors.lastname: Levkut
authors.forename: Frantisek
authors.initials: F
authors.lastname: Sabol
authors.forename: Peter
authors.initials: P
authors.lastname: Gál
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000293:injuries* / Q000473:pathology / Q000528:radiation effects*; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects*
chemical_list: D000305:Adrenal Cortex Hormones