title: Acute interstitial nephritis associated with ulcerative colitis.
abstract: Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. hirobumitokuyama@aol.com
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Tokuyama
authors.forename: Shu
authors.initials: S
authors.lastname: Wakino
authors.forename: Konosuke
authors.initials: K
authors.lastname: Konishi
authors.forename: Akinori
authors.initials: A
authors.lastname: Hashiguchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000293:Adolescent; D003093:Colitis, Ulcerative / Q000150:complications* / Q000276:immunology / Q000473:pathology; D003404:Creatinine / Q000097:blood; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D001613:beta 2-Microglobulin; D003404:Creatinine