title: Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis.
abstract: Despite recent advances in treatment of severe injured patients, e.g. due to damage control orthopaedics, multi organ dysfunction syndrome (MODS) and sepsis are major complications in daily practice. During one year 94 patients were prospectively collected.
  
  
  METHODS
  ISS 16, age 18-60 y, primary admission to our level-1 trauma center, survival > 48 hours after trauma. The development of MODS and sepsis were observed and different groups were formed (+/-). Demographic data revealed no significant differences between the subgroups. Comparing groups +MODS and -MODS significant differences on admission day were observed, when PCT showed first on day 2 after trauma differences. Regarding the development of sepsis PCT was advantageous to IL-6 showing significant higher plasma levels in group +sepsis from the first day after trauma. Serum levels of IL-6 and PCT could be useful in early identification of high risk patients to develop posttraumatic MODS. For sepsis PCT is the better prognostic factor.
authors.affiliation: Trauma Department, Hannover Medical School (MHH), Hannover, Germany. Haasper.carl@mh-hannover.de
authors.forename: C
authors.initials: C
authors.lastname: Haasper
authors.forename: M
authors.initials: M
authors.lastname: Kalmbach
authors.forename: G D
authors.initials: GD
authors.lastname: Dikos
authors.forename: R
authors.initials: R
authors.lastname: Meller
authors.forename: C
authors.initials: C
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Krettek
authors.forename: F
authors.initials: F
authors.lastname: Hildebrand
authors.forename: M
authors.initials: M
authors.lastname: Frink
mesh_terms: D000293:Adolescent; D000328:Adult; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology / Q000401:mortality; D009104:Multiple Trauma / Q000097:blood* / Q000150:complications; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D018805:Sepsis / Q000097:blood* / Q000209:etiology / Q000401:mortality; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology; D055815:Young Adult
chemical_list: C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide