An amphiphilic nanocarrier based on guar gum-graft-poly(epsilon-caprolactone) for potential drug-delivery applications.
Amphiphilic guar gum grafted with poly(epsilon-caprolactone) (GG-g-PCL) was fabricated as a drug-delivery carrier using microwave irradiation. The structure of the GG-g-PCL co-polymer was characterized by (1)H-NMR spectroscopy. By microwave irradiation, GG-g-PCL with high grafting percentage (>200%) was obtained in a short reaction time. The GG-g-PCL co-polymer is capable of self-assembling into nanosized spherical micelles in aqueous solution with the diameter of around 75-135 nm and 60-100 nm, as determined by DLS and TEM, respectively. The critical micelle concentration (CMC) of GG-g-PCL was found to be approx. 0.56 mg/l in a phosphate buffer solution. The drug-release profile showed that the GG-g-PCL micelles provided an initial burst release followed by a sustained release of the entrapped hydrophobic model drug, ketoprofen, over a period of 10-68 h. Under physiological conditions, the GG-g-PCL co-polymer hydrolytically degraded into lower-molecular-weight fragments within a 7-week period. These results suggest that the GG-g-PCL micelles could be used as a nanocarrier for in vitro controlled drug delivery.
Tiwari
Ashutosh
A
Division of Engineering Materials, National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi 110 012, India. ashunpl@gmail.com
Prabaharan
Mani
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D005685:Galactans / Q000138:chemical synthesis / Q000737:chemistry*; D007660:Ketoprofen / Q000008:administration & dosage*; D008351:Mannans / Q000138:chemical synthesis / Q000737:chemistry*; D008823:Micelles; D008872:Microwaves; D010316:Particle Size; D053149:Plant Gums / Q000138:chemical synthesis / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005685:Galactans; D008351:Mannans; D008823:Micelles; D053149:Plant Gums; D011091:Polyesters; C016240:polycaprolactone; D007660:Ketoprofen; C007894:guar gum