Mixing insulin aspart with detemir does not affect glucose excursion in children with type 1 diabetes.
OBJECTIVE
We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients.


METHODS
Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study.


RESULTS
The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.


CONCLUSIONS
Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.
Nguyen
Thanh M
TM
Department of Pediatrics-Endocrinology Section, Nemours Children's Clinic, Jacksonville, Florida, USA.
Renukuntla
Venkat S
VS
Heptulla
Rubina A
RA
D000293:Adolescent; D001786:Blood Glucose / Q000187:drug effects*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D007267:Injections; D061267:Insulin Aspart / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D000069057:Insulin Detemir; D049528:Insulin, Long-Acting / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D049528:Insulin, Long-Acting; D000069057:Insulin Detemir; D061267:Insulin Aspart