Uveitis related to juvenile idiopathic arthritis: familial cases and possible genetic implication in the pathogenesis.
OBJECTIVE
To describe four cases of familial Juvenile Idiopathic Arthritis (JIA) associated uveitis.


METHODS
Retrospective observational case series.


METHODS
Clinical data from patients who present familial JIA-associated uveitis are described and possible genetic influence in disease etiology is reviewed.


RESULTS
Two sisters, 6- and 7-year-old, developed bilateral anterior uveitis related to oligoarticular JIA. Arthritis in both began by the age of 18 months; uveitis developed simultaneously in one of them and less than one year after arthritis in the other one. Both received topical and systemic treatment to control the ocular disease. Glaucoma occurred in both cases and bilateral cataract in one case. In the other family, a 2-year-old girl developed unilateral uveitis in the context of oligoarticular JIA which was diagnosed by 1-year-old. The disease became soon bilateral and she received topical and systemic immunosuppressive treatment. Her mother suffered from bilateral anterior uveitis associated to oligoarticular inflammatory disease during her infancy, later diagnosed as JIA-associated uveitis.


CONCLUSIONS
Familial cases of JIA uveitis, although not very common, support the possible role of genetic influence in the pathogenesis of the disease, with horizontal and vertical inheritance being possible. The evolution of ocular disease is similar to the non-familial cases, except for an earlier age of onset.
Julián
Karina
K
Ophthalmology Department, Pitié-Salpêtrière Hospital, Paris, France.
Terrada
Céline
C
Quartier
Pierre
P
Lehoang
Phuc
P
Bodaghi
Bahram
B
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications* / Q000235:genetics; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D014792:Visual Acuity
D000319:Adrenergic beta-Antagonists; D000893:Anti-Inflammatory Agents; D002257:Carbonic Anhydrase Inhibitors; D005938:Glucocorticoids