title: [Role of lung fibroblast activation in radiation lung injury].
abstract: OBJECTIVE
  To investigate the role of lung fibroblast activation in radiation-induced lung injury.
  
  
  METHODS
  Thirty-five male Wistar rats were exposed to a single-dose 30 Gy irradiation of the right hemithorax or sham right lung irradiation. At 1, 7, 14, 28, 56 or 84 days after the irradiation, the rats were sacrificed for examination of alpha-smooth muscle actin (alpha-SMA) expression in the bilateral lung tissues using immunohistochemistry.
  
  
  RESULTS
  alpha-SMA expression in fibroblast increased significantly in the out-field and in-field lung tissues within 24 h after irradiation after the irradiation (P<0.001).
  
  
  CONCLUSIONS
  Activation of the lung fibroblasts occurred within 24 h after irradiation and found in ont-field and in-field lung tissues, suggesting that radiation-induced lung injury may not have an obvious latency.
authors.affiliation: Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Lai-yu
authors.initials: LY
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Qi-sheng
authors.initials: QS
authors.lastname: Li
authors.forename: Long-hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Shao-xi
authors.initials: SX
authors.lastname: Cai
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology*; D008168:Lung / Q000166:cytology / Q000473:pathology*; D008297:Male; D011832:Radiation Injuries / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000199:Actins; C498862:Acta2 protein, rat