title: [Endothelin in cardiovascular diseases pathophysiology].
abstract: Endothelin (ET-1) is the polypeptide about wide spectrum of physiological effects. The results of numerous experimental and clinical investigations showed its essential role also in the pathophysiology of various cardiovascular diseases (arteriosclerosis, heart failure, pulmonary hypertension, renal failure) and some neoplastic conditions. Thus, ET-1 blocking becomes an interesting tool of modern pharmacotherapy, targeted on neurohormonal mechanisms. The article briefly describes biochemical properties of ET-1 and ET and pathophysiological role of ET-1 in selected cardiovascular diseases.
authors.affiliation: Katedra Patofizjologii Collegium Medicum Uniwersytetu Jagiellońskiego. lukaszd@mp.pl
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Dobrek
authors.forename: Piotr
authors.initials: P
authors.lastname: Thor
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism*; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans
chemical_list: D019332:Endothelin-1