title: Mechanisms of leukocyte trafficking in allergic diseases: insights into new therapies targeting chemokines and chemokine receptors.
abstract: Marked inflammatory infiltration by activated leukocytes is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identify targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.
authors.affiliation: Paul-Ehrlich-Institut, Junior Research Group 'Experimental Allergology', Paul-Ehrlich St. 59, Langen 63225, Germany. todma@pei.de
authors.forename: Masako
authors.initials: M
authors.lastname: Toda
authors.forename: Takao
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ohbayashi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Maria
authors.initials: M
authors.lastname: Dawson
authors.forename: Cho Cho
authors.initials: CC
authors.lastname: Aye
authors.forename: Dai
authors.initials: D
authors.lastname: Miyazaki
authors.forename: Santa Jeremy
authors.initials: SJ
authors.lastname: Ono