Rapid access to morphinones: removal of 4, 5-ether bridge with Pd-catalyzed triflate reduction.
A new synthetic method for the removal of the 4, 5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.
Hupp
Christopher D
CD
Medicinal Chemistry Program, Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478.
Neumeyer
John L
JL