title: Chemotherapy in biliary tract cancer.
abstract: BACKGROUND
  Biliary Tract Cancer is a rare and aggressive tumor characterized by unresponsiveness to chemotherapy and radiotherapy in the vast majority of cases. Surgery offers the only possibility of a cure, though post-operative disease recurrence is common. Only few randomized trials with few patients have been conducted to in this setting of patients and standard chemotherapy has not been established yet.
  
  
  CONCLUSIONS
  This article summarizes the most important clinical trials regarding chemotherapy for biliary tract cancer and the first evidences regarding the adjuvant treatment. Moreover the clinical trials evaluating targeted therapy will be described, especially those assessing the role of anti-EGFR and antiangiogenic agents.
authors.affiliation: Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy. g.tonini@unicampus.it
authors.forename: G
authors.initials: G
authors.lastname: Tonini
authors.forename: M E
authors.initials: ME
authors.lastname: Frato
authors.forename: B
authors.initials: B
authors.lastname: Vincenzi
authors.forename: D
authors.initials: D
authors.lastname: Santini
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001661:Biliary Tract Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D016503:Drug Delivery Systems; D006801:Humans
chemical_list: D000970:Antineoplastic Agents