title: Structure-activity analysis of the Pseudomonas quinolone signal molecule.
abstract: We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: James
authors.initials: J
authors.lastname: Hodgkinson
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bowden
authors.forename: Warren R J D
authors.initials: WR
authors.lastname: Galloway
authors.forename: David R
authors.initials: DR
authors.lastname: Spring
authors.forename: Martin
authors.initials: M
authors.lastname: Welch
mesh_terms: D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D015394:Molecular Structure; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism; D011549:Pseudomonas / Q000187:drug effects* / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C407944:2-heptyl-3-hydroxy-4-quinolone; D009842:Oligopeptides; D015363:Quinolones; C042453:pyoverdin