Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.
Kv1.5 channels are homotetramers of alpha-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kv beta 1.3 assemblies with Kv alpha 1.5 and modifies its gating and pharmacology. A further knowledge of alpha-beta interactions and pharmacology will lead a better design of new drugs.
González
Teresa
T
Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), C/Arturo Duperier 4, 28029 Madrid, Spain.
David
Miren
M
Moreno
Cristina
C
Macías
Alvaro
A
Valenzuela
Carmen
C
D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology; D002045:Bupivacaine / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051664:Kv1.3 Potassium Channel / Q000737:chemistry* / Q000378:metabolism; D051666:Kv1.5 Potassium Channel / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D000779:Anesthetics, Local; C097044:KCNAB1 protein, human; D051664:Kv1.3 Potassium Channel; D051666:Kv1.5 Potassium Channel; D002045:Bupivacaine