title: [Clinical and functional changes in small intestine in the treatment of osteoarthritis with nonsteroidal antiinflammatory drugs].
abstract: Comparative evaluation of changing in functional conditions of the small intestine in using non-selective and selective non-steroidal anti-inflammatory drugs (NSAID) was estimated. The treatment of osteoarthrosis with NSAID lasted up to 3 years and longer then 3 years. As a result of integrated investigations of 92 patients it was revealed that NSAID damage the absorption primarily in proximal area of the small intestine, however the more prolonged period of using the drugs the more severe damage to intestinal digestion both of cavitary and membranous stages of hydrolysis occur. Enteropathy develops in a less extend of expression in comparison with non-selective NSAID in using selective NSAID. New pathogenic appropriateness concerning the role of hormones in functional disturbances of the small intestine in using NSAID was proved.
authors.forename: Ia M
authors.initials: IaM
authors.lastname: Vakhrushev
authors.forename: E A
authors.initials: EA
authors.lastname: Zagrebina
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D004063:Digestion / Q000187:drug effects*; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D007421:Intestine, Small / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal