Evaluation of anterior lenticonus in alport syndrome using tracey wavefront aberrometry and transmission electron microscopy.
OBJECTIVE
To evaluate the efficacy of Tracey wavefront aberrometry (Tracey Technologies, Houston, TX) and transmission electron microscopy for the detection of anterior lenticonus in Alport syndrome.


METHODS
Tracey wavefront aberrometry was used to treat a patient with bilateral anterior lenticonus who had a history of Alport syndrome. For transmission electron microscopic examination, anterior lens capsules were obtained during clear lens phacoemulsification and intraocular lens implantation.


RESULTS
Spherical aberrations were the predominant higher-order aberrations in the internal optics of both eyes. The Tracey wavefront aberrometer showed that most of the irregular astigmatism originated from the lenticular portion. Transmission electron microscopy of the specimens showed anterior lens capsules with decreased thickness and multiple dehiscences.


CONCLUSIONS
Tracey wavefront aberrometry and transmission electron microscopy are effective tools for evaluation of anterior lenticonus in Alport syndrome.
Kim
Kwan Soo
KS
Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
Kim
Mo Sae
MS
Kim
Joon Mo
JM
Choi
Chul Young
CY
D057128:Aberrometry / Q000379:methods*; D000328:Adult; D003315:Cornea / Q000473:pathology; D019781:Corneal Topography; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007905:Lens Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000648:ultrastructure*; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods*; D009394:Nephritis, Hereditary / Q000150:complications* / Q000175:diagnosis; D018918:Phacoemulsification / Q000379:methods; D012029:Refraction, Ocular; D015203:Reproducibility of Results; D016896:Treatment Outcome; D014792:Visual Acuity