Impact of guided bone regeneration and defect dimension on wound healing at chemically modified hydrophilic titanium implant surfaces: an experimental study in dogs.
OBJECTIVE
The aim of the present study was to evaluate the impact of guided bone regeneration and defect dimension on wound healing at chemically modified titanium implant surfaces (modSLA).


METHODS
ModSLA implants were placed at chronic-type lateral ridge defects of different heights (H1-H4: 2, 4, 6 and 8 mm) and randomly allocated to either (a) GBR (polyethylene glycol membrane + biphasic calcium phosphate) or (b) untreated control. At 2 and 8 weeks (n=6 dogs each), dissected blocks were processed for histomorphometrical analysis [e.g., percentage linear fill (PLF), regenerated area (RA)].


RESULTS
At 8 weeks, both groups revealed comparable mean PLF (%) [


METHODS
H1 (26.1 +/- 5.8)-H4 (60.4 +/- 11.8); GBR: H1 (8.3 +/- 5.3)-H4 (50.7 +/- 23.1)] and RA (mm(2)) [


METHODS
H1 (2.5 +/- 0.4)-H4 (7.4 +/- 4.1); GBR: H1 (1.8 +/- 1.0)-H4 (10.8 +/- 5.9)] values. A significant difference was observed for the mean PLF values at H1 defects.


CONCLUSIONS
It was concluded that (i) modSLA titanium implants supported bone regeneration and osseointegration at H1-H4 defects and (ii) the present GBR procedure did not seem to improve the outcome of vertical bone regeneration, but tended to increase the mean RA values.
Schwarz
Frank
F
Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. frank.schwarz@med.uni-dueseldorf.de
Jung
Ronald E
RE
Fienitz
Tim
T
Wieland
Marco
M
Becker
Jürgen
J
Sager
Martin
M
D016301:Alveolar Bone Loss / Q000473:pathology* / Q000601:surgery; D000818:Animals; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008567:Membranes, Artificial; D016348:Osseointegration; D011092:Polyethylene Glycols; D011897:Random Allocation; D013499:Surface Properties; D014025:Titanium
D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D008567:Membranes, Artificial; D011092:Polyethylene Glycols; D014025:Titanium