Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum.
The production of inositol phosphate from tritiated inositol was studied in striatal slices of neonatal rats. The excitatory amino acids glutamic, aspartic, quisqualic and ibotenic acids directly stimulated the formation of inositol phosphate in this system. The receptor mediating the response to quisqualic acid bore important pharmacological differences to the quisqualate-preferring receptor described electrophysiologically, notably in its insensitivity to antagonists. The receptor mediating the response to ibotenic acid bears no resemblance to any receptor subtype defined electrophysiologically; l -serine -O- phosphate is an antagonist of this response. N-methylaspartic acid selectively depressed the stimulation of inositol phosphate formation evoked by carbachol in a calcium dependent manner. The receptor mediating the inhibitory response to N-methylaspartate appears pharmacologically similar to the NMDA-preferring receptor defined electrophysiologically.
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Centre de Recherche de Gennevilliers, Rhône-Poulenc Santé, 35, Quai Du Moulin-De-Cage, 92231 Gennevilliers, France.
Perrier
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