[Effects of maternal methyl-supplemented diet on glucocorticoid receptor gene expression in the hippocampal of rats selected for behavior].
Here we report that selection for behavior and maternal methyl-supplemented diet alters rat hippocampus glucocorticoid receptor (GR) mRNA expression. Same selection is associated with increased GR mRNA expression as compared with aggressive rats, whereas maternal methyl-supplemented diet inhibits tame rat GR gene activity. The gene promoter methylation is a way to alter GR expression.
Gerbek
Iu E
IuE
Os'kina
I N
IN
Gulevich
R G
RG
Pliusnina
I Z
IZ
D000374:Aggression; D000818:Animals; D001522:Behavior, Animal; D003345:Corticosterone / Q000097:blood; D019175:DNA Methylation; D004032:Diet; D005260:Female; D015870:Gene Expression; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics / Q000503:physiopathology; D039401:Prenatal Nutritional Physiological Phenomena / Q000235:genetics; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013315:Stress, Psychological / Q000097:blood / Q000235:genetics / Q000503:physiopathology
D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D003345:Corticosterone