title: Synthesis of pyrazolines by a site isolated resin-bound reagents methodology.
abstract: The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities.
authors.affiliation: CNRS UMR COBRA, INSA et Université de Rouen, FR 3038, IRCOF (Research Institute in Fine Organic Chemistry), rue Tesnière, BP 08, 76131 Mont Saint Aignan, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gembus
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bonnet
authors.forename: François
authors.initials: F
authors.lastname: Janin
authors.forename: Pierre
authors.initials: P
authors.lastname: Bohn
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Brière
mesh_terms: D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D011720:Pyrazoles; D012117:Resins, Synthetic; C031280:pyrazole