[Cerebral plasticity: from bench to bedside in stroke treatment].
It has long been believed that cerebral lesions were irreversible in the adult human brain. However, the spontaneous improvement in functional outcome observed in the following weeks after cerebral ischemia suggests plasticity phenomenons involving postischemic neuronal network reorganization. Regarding the large prevalence of stroke in industrialized countries, and the few available treatments, the understanding of cerebral plasticity has become an important issue but also a potential source of new therapeutic approaches in stroke. Thus, "constraint induced therapy" and repetitive transcranial magnetic stimulation (rTMS) are based on the concept of local but also remote consequences of the ischemic focal lesion. Cell-therapy is based on the capacity of stem cells to respond to hypoxic signals and adapt their phenotype to the host organ, but above all to release cytokines locally and boost endogeneous repair mechanisms. We could consider to perform in the future a sequential treatment with fibrinolysis, stem cell therapy, repetitive transcranial magnetic stimulation and constraint-induced therapy in the same patient.
Deroide
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Service de physiologie explorations fonctionnelles, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
Nih
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LR
Dinh
R Y Tran
RY
Lévy
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B
Kubis
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D006801:Humans; D009415:Nerve Net; D009473:Neuronal Plasticity; D033581:Stem Cell Transplantation; D020521:Stroke / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation; D057170:Translational Research, Biomedical