Glycemia and levels of cerebrospinal fluid amyloid and tau in patients attending a memory clinic.
OBJECTIVE
To determine the association between markers of glycemia and cerebrospinal fluid (CSF) amyloid beta 1-42 (Abeta42) and tau levels in patients attending a memory clinic.


METHODS
Cross-sectional study.


METHODS
Memory clinic.


METHODS
Two hundred forty-five consecutive patients attending a memory clinic. Clinical diagnoses were subjective cognitive complaints (n=91), mild cognitive impairment (n=62), Alzheimer's disease (n=58), and other dementia (n=34). Twenty-one patients had diabetes mellitus.


METHODS
Glycosylated hemoglobin (HbA1c); fasting blood glucose levels; and CSF levels of Abeta42, total tau, and p-tau 181.


RESULTS
In regression analyses across the whole study sample adjusted for age, sex, and diagnostic group, there was no relationship between HbA1c or fasting glucose and CSF tau, p-tau 182, or Abeta42 levels. Stratification for diabetes mellitus did not change the results.


CONCLUSIONS
These observations do not support the hypothesis that the association between dysglycemia and impaired cognitive functioning is mediated through aberrant amyloid or tau metabolism.
Exalto
Lieza G
LG
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
van der Flier
Wiesje M
WM
Scheltens
Phillip
P
Biessels
Geert Jan
GJ
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001786:Blood Glucose / Q000378:metabolism*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D012307:Risk Factors; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016229:Amyloid beta-Peptides; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010446:Peptide Fragments; D016875:tau Proteins; C075222:amyloid beta-protein (1-42); C517652:hemoglobin A1c protein, human