title: Optimizing the use of sunitinib in metastatic renal cell carcinoma: an update from clinical practice.
abstract: Sunitinib is a reference standard of care for the treatment of metastatic renal cell carcinoma (mRCC). While the tolerability of sunitinib is consistent across clinical studies, the impact of tolerability on clinical benefit necessitates effective therapy management, focusing on optimization of dosing, treatment duration, and management of adverse events. Managing individual tolerability concerns in clinical practice should include patient education and practical management strategies. We review the sunitinib tolerability profile in mRCC and describe practical strategies to manage adverse events in order to maximize clinical benefit. These strategies may allow long-term sunitinib treatment, thereby optimizing the available clinical efficacy.
authors.affiliation: University of Vienna, Vienna, Austria. manuela.schmidinger@meduniwien.ac.at
authors.forename: Manuela
authors.initials: M
authors.lastname: Schmidinger
authors.forename: Dirk
authors.initials: D
authors.lastname: Arnold
authors.forename: Cezary
authors.initials: C
authors.lastname: Szczylik
authors.forename: John
authors.initials: J
authors.lastname: Wagstaff
authors.forename: Alain
authors.initials: A
authors.lastname: Ravaud
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001247:Asthenia / Q000139:chemically induced / Q000517:prevention & control; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005221:Fatigue / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008487:Medical History Taking; D009362:Neoplasm Metastasis / Q000188:drug therapy; D016016:Proportional Hazards Models; D011758:Pyrroles / Q000009:adverse effects / Q000627:therapeutic use*; D000077210:Sunitinib
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib