title: Transcutaneous oxygen tension: a useful predictor of ulcer healing in critical limb ischaemia.
abstract: OBJECTIVE
  To investigate the threshold of transcutaneous oxygen tension (TcPO(2)) values in predicting ulcer healing in patients with critical limb ischaemia in a prospective study.
  
  
  METHODS
  50 patients suffering from critical limb ischaemia with chronic ischemic ulcers or gangrenous toes were enrolled in this study between January and December 2008. Their demographic data and ankle brachial pressure index (ABPI) were collected. Baseline ulcers were measured with a wound measurement system (Visitrak, Smith & Nephew). TcPO(2) was measured at rest in the supine position and with 30 degrees leg elevation. The patients with infective and ischemic ulcers underwent debridement and gangrenous toes were amputated. Ulcer outcome was classified as either: (1) A healing ulcer, showing good epithelialisation or granulation at both base and edges, or a decrease in ulcer area during the study; or (2) A non-healing ulcer, showing poor granulation tissue formation or a pale base and necrotic edges, or deterioration in an ischaemic ulcer.
  
  
  RESULTS
  The mean age of the patients was 67.6 + or - 10.8 years. The most common risk factor was hypertension (90%). Mean ABPI was 0.75 + or - 0.39. 13 patients (26%) had a TcPO(2) of less than 20 mmHg, of which none showed any improvement in ulcer healing (p<0.001). 15 patients (30%) had a TcPO(2) of more than 40 mmHg, of which all progressed to complete ulcer healing (p<0.001). In the borderline group (20-40 mmHg, 22 patients, 44%), 10 patients (45%) had a TcPO2 drop of <10 mmHg with 30 degrees leg elevation, of which 8 achieved complete ulcer healing (p<0.001). 12 patients (55%) had a TcPO(2) drop of >10 mmHg with 30 degrees leg elevation, of which 11 showed no ulcer healing (p<0.001).
  
  
  CONCLUSIONS
  TcPO(2) measurement is an accurate, non-invasive, and good predictor of ischemic ulcer healing, for cut-off TcPO(2) values of less than 20 mmHg and more than 40 mmHg. In addition, the leg elevation method for TcPO(2) might provide an important adjunct in the assessment of patients with borderline values.
authors.affiliation: Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: C
authors.initials: C
authors.lastname: Ruangsetakit
authors.forename: K
authors.initials: K
authors.lastname: Chinsakchai
authors.forename: P
authors.initials: P
authors.lastname: Mahawongkajit
authors.forename: C
authors.initials: C
authors.lastname: Wongwanit
authors.forename: P
authors.initials: P
authors.lastname: Mutirangura
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D055109:Ankle Brachial Index; D001785:Blood Gas Monitoring, Transcutaneous; D016009:Chi-Square Distribution; D016638:Critical Illness; D003646:Debridement; D005260:Female; D016523:Foot Ulcer / Q000097:blood* / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000601:surgery; D023821:Limb Salvage; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014034:Toes / Q000098:blood supply*; D016896:Treatment Outcome; D014945:Wound Healing