Maternal levels of prostacyclin, thromboxane, ICAM, and VCAM in normal and preeclamptic pregnancies.
OBJECTIVE
To evaluate whether impaired endothelial function and endothelial inflammatory response occur in parallel in the women with preeclampsia.


METHODS
Venous blood was drawn from normal (n=40) and severe preeclamptic (sPE) (n=40) pregnant women when they were admitted to the L&D Unit and 24 hrs after delivery. Plasma and serum samples were extracted and measured for 6-keto PGF1α and TXB(2) (stable metabolites of PGI2 and TXA2), and intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) by ELISA. Data are analyzed by Mann-Whitney test and paired t-test. The statistical significance is set as P<0.05. Results  Plasma 6-keto PGF1α levels were significantly reduced at admission and 24hr after delivery in sPE compared to normal pregnant controls, P<0.01. The ratio of 6-keto PGF1α and TXB(2) was significant less in sPE than that in normal pregnant controls before delivery. There was no significant difference for ICAM and VCAM levels between normal and patients with sPE before and after delivery.


CONCLUSIONS
Maternal 6-keto PGF1α levels and the ratio of 6-keto PGF1α and TXB(2) were decreased in patients with sPE compared to normal pregnant controls. In contrast, maternal ICAM and VCAM levels were not different between the two groups. These data suggest that serum ICAM and VCAM levels may not be sensitive inflammatory biomarkers for preeclampsia.
Lewis
David F
DF
Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio, USA.
Canzoneri
Bernard J
BJ
Gu
Yang
Y
Zhao
Shuang
S
Wang
Yuping
Y
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D004727:Endothelium / Q000276:immunology / Q000378:metabolism*; D011464:Epoprostenol / Q000031:analogs & derivatives / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
D015415:Biomarkers; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D013928:Thromboxane A2; D011464:Epoprostenol