title: [Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient].
abstract: A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.
authors.affiliation: Universitair Medisch Centrum Groningen, Afd. Intensive Care Volwassenen, The Netherlands. h.aardema@int.umcg.nl
authors.forename: Heleen
authors.initials: H
authors.lastname: Aardema
authors.forename: Jaap E
authors.initials: JE
authors.lastname: Tulleken
authors.forename: Ries J M
authors.initials: RJ
authors.lastname: van den Biggelaar
authors.forename: Bert A
authors.initials: BA
authors.lastname: Wolters
authors.forename: Corine M
authors.initials: CM
authors.lastname: de Jager
authors.forename: Charles A B
authors.initials: CA
authors.lastname: Boucher
authors.forename: Annelies
authors.initials: A
authors.lastname: Riezebos-Brilman
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy* / Q000821:virology*; D053243:Zanamivir / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D053243:Zanamivir