title: Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part II: Biomimetic potential and applications.
abstract: In order to evaluate the biomedical potential of three-dimensional chitinous scaffolds of poriferan origin, chondrocyte culturing experiments were performed. It was shown for the first time that freshly isolated chondrocytes attached well to the chitin scaffold and synthesized an extracellular matrix similar to that found in other cartilage tissue engineering constructs. Chitin scaffolds also supported deposition of a proteoglycan-rich extracellular matrix of chondrocytes seeded bioconstructs in an in vivo environment. We suggest that chitin sponge scaffolds, apart from the demonstrated biomedical applications, are highly optimized structures for use as filtering systems, templates for biomineralization as well as metallization in order to produce catalysts.
authors.affiliation: Institute of Bioanalytical Chemistry, Dresden University of Technology, 01069 Dresden, Germany. Hermann.ehrlich@tu-dresden.de
authors.forename: H
authors.initials: H
authors.lastname: Ehrlich
authors.forename: E
authors.initials: E
authors.lastname: Steck
authors.forename: M
authors.initials: M
authors.lastname: Ilan
authors.forename: M
authors.initials: M
authors.lastname: Maldonado
authors.forename: G
authors.initials: G
authors.lastname: Muricy
authors.forename: G
authors.initials: G
authors.lastname: Bavestrello
authors.forename: Z
authors.initials: Z
authors.lastname: Kljajic
authors.forename: J L
authors.initials: JL
authors.lastname: Carballo
authors.forename: S
authors.initials: S
authors.lastname: Schiaparelli
authors.forename: A
authors.initials: A
authors.lastname: Ereskovsky
authors.forename: P
authors.initials: P
authors.lastname: Schupp
authors.forename: R
authors.initials: R
authors.lastname: Born
authors.forename: H
authors.initials: H
authors.lastname: Worch
authors.forename: V V
authors.initials: VV
authors.lastname: Bazhenov
authors.forename: D
authors.initials: D
authors.lastname: Kurek
authors.forename: V
authors.initials: V
authors.lastname: Varlamov
authors.forename: D
authors.initials: D
authors.lastname: Vyalikh
authors.forename: K
authors.initials: K
authors.lastname: Kummer
authors.forename: V V
authors.initials: VV
authors.lastname: Sivkov
authors.forename: S L
authors.initials: SL
authors.lastname: Molodtsov
authors.forename: H
authors.initials: H
authors.lastname: Meissner
authors.forename: G
authors.initials: G
authors.lastname: Richter
authors.forename: S
authors.initials: S
authors.lastname: Hunoldt
authors.forename: M
authors.initials: M
authors.lastname: Kammer
authors.forename: S
authors.initials: S
authors.lastname: Paasch
authors.forename: V
authors.initials: V
authors.lastname: Krasokhin
authors.forename: G
authors.initials: G
authors.lastname: Patzke
authors.forename: E
authors.initials: E
authors.lastname: Brunner
authors.forename: W
authors.initials: W
authors.lastname: Richter
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D002356:Cartilage / Q000187:drug effects / Q000502:physiology; D002686:Chitin / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019902:Chondrocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D002686:Chitin