Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles.
Three-component reactions with 3,4-diiodoalk-2-enoic derivatives, primary amines, and terminal alkynes proceeded to give trisubstituted pyrroles in fair to good yields in the presence of palladium and copper catalysts under mild reaction conditions.
Groupe S.U.C.R.E.S-UMR 7565 Nancy Université- CNRS, BP 70239, F-54506, Nancy Vandoeuvre, France.
Sandrine
S
Lamandé-Langle
Mohamed
M
Abarbri
Jérôme
J
Thibonnet
Alain
A
Duchêne
Jean-Luc
JL
Parrain
D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D000588:Amines; D011758:Pyrroles; D010165:Palladium; D003300:Copper