Cytotoxic activity of trijugin-type limonoids from Cipadessa baccifera.
Two new trijugin-type limonoids, cipatrijugins E and F (1 and 2), together with the known cipatrijugins A and D (3-4), were isolated from the stem bark of Cipadessa baccifera. All structures were elucidated by spectroscopic analysis. The in vitro cytotoxicity of compounds 1-4 was also tested. Compound 1 showed significant in vitro cytotoxicity against MCF-7, SW480, HL-60, and SMMC-7721 cells, with IC(50) values of 5.0, 6.6, 4.5, and 21.6 µM, respectively.
Ning
Jing
J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Di
Ying-Tong
YT
Wang
Yuan-Yuan
YY
He
Hong-Ping
HP
Fang
Xin
X
Li
Yan
Y
Li
Shun-Lin
SL
Hao
Xiao-Jiang
XJ
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D036701:Limonins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; D010936:Plant Extracts