Oxidative stress and level of-iron indices in coronary heart disease patients.
OBJECTIVE
Oxidative stress is characterized by an increased concentration of oxygen free radicals which can cause a critical, or even an irreversible, cell injury. The study was designed to determine and compare the levels of oxidative stress and iron indices in Coronary Heart Disease and healthy individuals.


METHODS
Blood malondialdehyde, iron, total iron-binding capacity, transferrin saturation and ferretin levels were determined in 140 Coronary Heart Disease and 100 healthy subjects.


RESULTS
Values of blood malondialdehyde, iron, transferrin saturation and ferretin were observed to be significantly increased with exception of total iron-binding capacity, which was significantly decreased (p < 0.005) in Coronary Heart Disease patients when compared with normal healthy controls.


CONCLUSIONS
Elevated serum malondialdehyde, iron concentration and body iron stores in patients reveal a possible role of iron indices in the development of coronary atherosclerosis. Therefore, it is suggested by this study that levels of malondialdehyde and biochemical markers of body iron stores can be used as an early investigative tool for assessing the oxidative stress in coronary heart disease.
Department of Biochemistry, Institute of Chemical Sciences, University of Peshawar, Pakistan. mahmad29@hotmail.com
Muhammad
M
Ahmad
Mudassir Ahmad
MA
Khan
Abdus Sattar
AS
Khan
D015415:Biomarkers; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005293:Ferritins / Q000097:blood; D006305:Health Status Indicators; D006801:Humans; D019266:Iron, Dietary / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D010154:Pakistan / Q000453:epidemiology; D018570:Risk Assessment; D014168:Transferrin
D015415:Biomarkers; D019266:Iron, Dietary; D014168:Transferrin; D008315:Malondialdehyde; D005293:Ferritins