Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
We conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs were carried forward for replication in samples from individuals of the Chinese Han (5,910 cases and 9,916 controls) and Chinese Uygur (713 cases and 824 controls) populations. We identified two independent association signals within the major histocompatibility complex (MHC) region (rs11966200, Pcombined=1.48x10(-48), OR=1.90; rs9468925, Pcombined=2.21x10(-33), OR=0.74). Further analyses suggested that the strong association at rs11966200 might reflect the reported association of the HLA-A*3001, HLA-B*1302, HLA-C*0602 and HLA-DRB1*0701 alleles and that the association at rs9468925 might represent a previously unknown HLA susceptibility allele. We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo.
Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Cheng
C
Quan
Yun-Qing
YQ
Ren
Lei-Hong
LH
Xiang
Liang-Dan
LD
Sun
Ai-E
AE
Xu
Xing-Hua
XH
Gao
Hong-Duo
HD
Chen
Xiong-Ming
XM
Pu
Ri-Na
RN
Wu
Chao-Zhao
CZ
Liang
Jia-Bin
JB
Li
Tian-Wen
TW
Gao
Jian-Zhong
JZ
Zhang
Xiu-Li
XL
Wang
Jun
J
Wang
Rong-Ya
RY
Yang
Ling
L
Liang
Jian-Bin
JB
Yu
Xian-Bo
XB
Zuo
Sheng-Quan
SQ
Zhang
Shu-Mei
SM
Zhang
Gang
G
Chen
Xiao-Dong
XD
Zheng
Pan
P
Li
Jun
J
Zhu
Yong-Wei
YW
Li
Xiao-Dong
XD
Wei
Wei-Song
WS
Hong
Ying
Y
Ye
Yong
Y
Zhang
Wei-Su
WS
Wu
Hui
H
Cheng
Pu-Ling
PL
Dong
Da-Yan
DY
Hu
Yang
Y
Li
Min
M
Li
Xin
X
Zhang
Hua-Yang
HY
Tang
Xian-Fa
XF
Tang
Sheng-Xin
SX
Xu
Su-Min
SM
He
Yong-Mei
YM
Lv
Min
M
Shen
Hong-Quan
HQ
Jiang
Ying
Y
Wang
Kai
K
Li
Xiao-Jing
XJ
Kang
Yu-Qin
YQ
Liu
Li
L
Sun
Zhi-Fang
ZF
Liu
Shao-Qiong
SQ
Xie
Cheng-Yao
CY
Zhu
Qiang
Q
Xu
Jin-Ping
JP
Gao
Wen-Long
WL
Hu
Cheng
C
Ni
Ting-Meng
TM
Pan
Yun
Y
Li
Sha
S
Yao
Cai-Feng
CF
He
Yang-Sheng
YS
Liu
Ze-Ying
ZY
Yu
Xian-Yong
XY
Yin
Feng-Yu
FY
Zhang
Sen
S
Yang
Youwen
Y
Zhou
Xue-Jun
XJ
Zhang
D000293:Adolescent; D000328:Adult; D000368:Aged; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D014820:Vitiligo / Q000235:genetics*; D055815:Young Adult
D006680:HLA Antigens; D015234:HLA-A Antigens; C541139:HLA-A*30:01 antigen; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains