Metabolic syndrome increases carotid artery stiffness: the Northern Manhattan Study.
BACKGROUND
Arterial stiffness, an intermediate pre-clinical marker of atherosclerosis, has been associated with an increased risk of stroke and cardiovascular disease. The metabolic syndrome and its components are established cardiovascular disease risk factors and may also increase arterial stiffness; however, data regarding this are limited.


OBJECTIVE
The goal of this study was to determine the association between the metabolic syndrome and carotid artery stiffness in an elderly multi-ethnic cohort.


METHODS
Carotid artery stiffness was assessed by carotid ultrasound as part of the Northern Manhattan Study, a prospective population-based cohort of stroke-free individuals. Carotid artery stiffness was calculated as [ln(systolic BP/diastolic BP)/strain], where strain was [(systolic diameter-diastolic diameter)/diastolic diameter]. Metabolic syndrome was defined by the National Cholesterol Education Program: Adult Treatment Panel III criteria. LogSTIFF was analysed as the dependent variable in linear regression models, adjusting for demographics, education, current smoking, presence of carotid plaque and intima-media thickness.


RESULTS
Carotid artery stiffness was analysed in 1133 Northern Manhattan Study subjects (mean age 65 +/- 9 years; 61% women; 58% Hispanic, 22% Black and 20% Caucasian). The prevalence of the metabolic syndrome was 49%. The mean LogSTIFF was 2.01 +/- 0.61 among those with the metabolic syndrome and 1.90 +/- 0.59 among those without the metabolic syndrome (P=0.003). The metabolic syndrome was significantly associated with increased logSTIFF in the final adjusted model (parameter estimate beta=0.100, P=0.01). Among individual metabolic syndrome components, waist circumference and elevated blood pressure were most significantly associated with a mean increase in logSTIFF (P<0.01).


CONCLUSIONS
The metabolic syndrome is significantly associated with increased carotid artery stiffness in a multiethnic population. Increased carotid artery stiffness may, in part, explain a high risk of stroke among individuals with the metabolic syndrome.
Della-Morte
David
D
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA.
Gardener
Hannah
H
Denaro
Federica
F
Boden-Albala
Bernadette
B
Elkind
Mitchell S V
MS
Paik
Myunghee C
MC
Sacco
Ralph L
RL
Rundek
Tatjana
T
D000368:Aged; D000465:Algorithms; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D012959:Socioeconomic Factors; D014463:Ultrasonography