From biological gastroenterology to fundamental neurosciences: how studies in gastric emptying have led to the discovery of a new mechanism of neuronal functioning.
Gastric emptying undergoes complex regulation by the nervous system, which organizes in particular the inhibition of duodenum motility after a rise in intra-gastric pressure: the gastro-duodenal inhibitory reflex. It was first shown in mammals that this reflex could be organized by a sympathetic ganglion, the coeliac plexus. The excitation of gastric mechanosensitive fibres leads in this ganglion to the release of a neurotransmitter, which in turn activates ganglionic neurones leading to inhibition of the duodenum contractions. It rapidly became apparent that this reflex presented striking properties since it was organized in the absence of action potentials along the nerve fibres. Then it was shown that the neurotransmitter released in the coeliac plexus was gaseous: nitric oxide (NO). The nature of the mechanism conducting, without action potentials, the excitation along the nerve fibres was recently determined. This mechanism necessitates the integrity of particular areas of the neuronal membrane (the lipid rafts) and the activation in cascade of the following second messenger sequence: ceramide, calcium, NO and guanosine cyclic monophosphate (c-GMP). These results show how studies in biological gastroenterology have led to the rethinking of one of the central dogmas in neuroscience according to which excitation is only conducted along the nerves by the action potential.
Hôpital Douglas, Institut Universitaire en Santé Mentale, 6875, Boulevard LaSalle, Montréal, Canada.
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D000200:Action Potentials / Q000502:physiology; D002447:Celiac Plexus / Q000502:physiology*; D004386:Duodenum / Q000294:innervation / Q000502:physiology*; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D009412:Nerve Fibers / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D013270:Stomach / Q000294:innervation / Q000502:physiology*
D009569:Nitric Oxide