Altered cell cycle regulation helps stem-like carcinoma cells resist apoptosis.
Reemergence of carcinomas following chemotherapy and/or radiotherapy is not well understood, but a recent study in BMC Cancer suggests that resistance to apoptosis resulting from altered cell cycle regulation is crucial.
Paul D Coverdell Center for Biomedical and Health Science, Department of Biochemistry and Molecular Biology, University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA.
James
J
Chappell
Stephen
S
Dalton
D017209:Apoptosis / Q000502:physiology*; D002277:Carcinoma / Q000503:physiopathology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000503:physiopathology*; D014411:Neoplastic Stem Cells / Q000502:physiology*
D018797:Cell Cycle Proteins; D018960:Hyaluronan Receptors