Skeletal muscle-melanocyte association during tadpole tail resorption in a tropical frog, Clinotarsus curtipes Jerdon (Anura, Ranoidea).
We tested the hypothesis that melanin has a role as a molecule within the thyroid-mediated cascade. Light microscopic and ultrastructural changes in the skeletal muscle during tail resorption in tadpoles of the tropical frog Clinotarsus curtipes Jerdon (Anura: Ranoidea) were observed. Light microscopic analysis at metamorphic stage XVIII showed a melanized epidermis. A gradual migration of melanocytes from the epidermis to the dermis and filopodia of melanocytes pervading the skeletal muscle preceded tail resorption. The invasion of melanocytes into the muscle bundles coincided with the breakdown of the muscle bundles into sarcolytes and the arrival of macrophages at this site. This would suggest that the melanocyte-sarcolyte association signals the arrival of macrophages at these sites as metamorphosis progressed. Melanophages, macrophages with melanin granules, were observed at the climax stage of XXIII. The sarcolytes and the melanin granules were phagocytosed by macrophages so as to completely cleanse the exocytic muscle debris and the melanin granules. The presence of large melanomacrophage centers in the tadpole liver at metamorphic climax suggests that these phagocytic macrophages were further processed in the liver and, likely, in the spleen. It is proposed that melanin, a byzantine molecule, has a role in the cascade of events leading to tail resorption in anuran tadpoles.
Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram 695581, India.
Lekha
L
Divya
Reston S
RS
Beyo
Parameswaran
P
Sreejith
Mohammad A
MA
Akbarsha
Oommen V
OV
Oommen
D000818:Animals; D001862:Bone Resorption / Q000378:metabolism*; D007814:Larva / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism*; D008675:Metamorphosis, Biological / Q000502:physiology*; D046529:Microscopy, Electron, Transmission; D018482:Muscle, Skeletal / Q000166:cytology*; D011898:Ranidae / Q000378:metabolism* / Q000502:physiology; D012867:Skin / Q000166:cytology; D013623:Tail / Q000254:growth & development* / Q000648:ultrastructure
D008543:Melanins