Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis.
Burkholderia pseudomallei and Burkholderia mallei are closely related gram-negative bacteria that can cause serious diseases in humans and animals. This review summarizes the current and rapidly expanding knowledge on the specific virulence factors employed by these pathogens and their roles in the pathogenesis of melioidosis and glanders. In particular, the contributions of recently identified virulence factors are described in the context of the intracellular lifestyle of these pathogens. Throughout this review, unique and shared virulence features of B. pseudomallei and B. mallei are discussed.
Galyov
Edouard E
EE
Department of Infection, Immunity and Inflammation, MSB, University of Leicester, Leicester LE1 9HN, United Kingdom. eg98@le.ac.uk
Brett
Paul J
PJ
DeShazer
David
D
D006801:Humans; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D042726:Burkholderia mallei / Q000235:genetics / Q000472:pathogenicity; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000472:pathogenicity; D003593:Cytoplasm / Q000382:microbiology; D005896:Glanders / Q000382:microbiology / Q000473:pathology; D008554:Melioidosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism; D006736:Horses; D000818:Animals
D001426:Bacterial Proteins; D037521:Virulence Factors