Cu(II): a "signaling molecule" of the mangrove endophyte Fusarium oxysporum ZZF51?
We previously reported the isolation of Cu-fusaric acid (Cu-FA) complex from the mangrove endophyte Fusarium oxysporum ZZF51. In this study, we explored the mechanism of Cu-FA production in the strain ZZF51 by comparing with that of another endophyte Fusarium sp. B2, which produced FA but not Cu-FA in the same culture condition. The results allowed us to hypothesize that Cu(2+) may act as a "signaling molecule" to awaken the silent FA biosynthetic genes in ZZF51, inducing intracellular production of FA followed by chelation with Cu(2+). This signaling network was triggered specifically by Cu(2+) and may be interfered by other metal ions.
Pan
Jia-hui
JH
School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, 510275, Guangzhou, China.
Lin
Yong-cheng
YC
Tan
Ni
N
Gu
Yu-cheng
YC
D056831:Coordination Complexes / Q000378:metabolism*; D003300:Copper / Q000494:pharmacology / Q000502:physiology*; D005669:Fusaric Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism; D005670:Fusarium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D010935:Plant Diseases; D015398:Signal Transduction / Q000187:drug effects
D056831:Coordination Complexes; D003300:Copper; D005669:Fusaric Acid