[Serologic diagnosis of congenital toxoplasmosis].
OBJECTIVE
To investigate the serological diagnosis of congenital toxoplasmosis and the prevalence of antibodies against toxoplasma in pregnant women in our area.


METHODS
Toxoplasmosis seroprevalence was analyzed in 68 712 serum samples from 47 635 pregnant women living in the catchment area of Hospital Miguel Servet during the period of 1992 to 2008. Detection of toxoplasma-specific immunoglobulins (IgM, IgA, IgG) and IgG avidity studies were carried out in the microbiology laboratory.


RESULTS
Toxoplasmosis seroprevalence was 31.9%. The incidence of primary infection was 0.01% in susceptible pregnant women. Fifteen women seroconverted during pregnancy, and 9 of them had infants with congenital toxoplasmosis.


CONCLUSIONS
The cases of congenital toxoplasmosis were detected by maternal seroconversion during pregnancy. IgA was the most sensitive marker for the detection of congenital infection in neonates.
Roc
María Lourdes
ML
Servicio de Microbiología, Hospital Universitario Miguel Servet, Zaragoza, España. lroc@salud.aragon.es
Palacián
María Pilar
MP
Lomba
Elena
E
Monforte
María Luisa
ML
Rebaje
Victor
V
Revillo Pinilla
María José
MJ
D000913:Antibodies, Protozoan / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood; D012189:Retrospective Studies; D012698:Serologic Tests; D014123:Toxoplasmosis / Q000097:blood; D014125:Toxoplasmosis, Congenital / Q000097:blood* / Q000175:diagnosis*
D000913:Antibodies, Protozoan