Effect of a novel antiinflammatory polyherbal preparation (Sudarshanam oil) on hematological parameters in Wistar rats.
The present investigation was an attempt to evaluate the anti-inflammatory effect of a polyherbal preparation (Sudarshanam Oil) on hematological parameters in Wistar rats. This polyherbal formula contains main ingredients of Tinaspora Cordifolia, Curcuma longa, Terminalia chebula, Emblica officinalis, Andrographis paniculata and Terminalia belerica. The active phytochemicals such as tannins, glycosides, flavonoids and triterpenoids are extracted from these herbal plants. And extract was prepared in corn oil. Young adult Wistar rats of either sex were divided into 4 groups and each group having 6 males and 6 females were dosed for 28 days. First group was the control group which was dosed with corn oil as vehicle (15 mL/kg body weight). Groups II, III and IV were treated with different doses of Sudarshanam oil, viz. as 5 mL/kg, 10 mL/kg and 15 mL/kg body weight respectively. On 29th day, after overnight fasting, the blood samples were collected through cardiac puncture under CO2 anaesthesia. The blood samples were collected and transferred into prelabelled vaccutainer coated with EDTA for hematological parameters investigation by using Advia-120 hematology analyser. The results revealed that no treatment related adverse effects in any of the hematological parameters. Thus, Sudarshanam oil proves to be highly potent, novel anti-inflammatory preparation which can be a challenge against allopathic anti-inflammatory drug.
Patel
Chintan D
CD
Modi
Vandana D
VD
Chakraborty
Bhaswat S
BS
Mathuria
Neeta
N
Dadhaniya
Paresh
P
Borade
Prasad A
PA
Morankar
Pravin
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D003314:Corn Oil / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D010976:Platelet Count; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D006454:Hemoglobins; D014677:Pharmaceutical Vehicles; D028321:Plant Preparations; C550188:Sudarshanam oil; D003314:Corn Oil