Concise copper-catalyzed one-pot tandem synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives.
A simple and efficient copper-catalyzed one-pot tandem method has been developed for synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives via reactions of substituted 2-halo-N-(2-halophenyl)benzamides with alkyl 2-cyanoacetates or malononitrile under mild conditions.
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Juyou
J
Lu
Xiaoyu
X
Gong
Haijun
H
Yang
Hua
H
Fu
D001549:Benzamides; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D044182:Benzylisoquinolines; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D001549:Benzamides; D001562:Benzimidazoles; D044182:Benzylisoquinolines; D007546:Isoquinolines; D003300:Copper