Transfer hydrogenation in water: enantioselective, catalytic reduction of alpha-cyano and alpha-nitro substituted acetophenones.
Catalytic reduction of alpha-substituted acetophenones under conditions involving asymmetric transfer hydrogenation in water is described. The reaction is conducted in water and open to air, and formic acid is used as reductant.
Laboratorium für organische Chemie, ETH Zürich, Hönggerberg, Switzerland.
Omid
O
Soltani
Martin A
MA
Ariger
Henar
H
Vázquez-Villa
Erick M
EM
Carreira
D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005561:Formates / Q000737:chemistry; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D000098:Acetophenones; D005561:Formates; D009942:Organometallic Compounds; D014867:Water; C030544:formic acid; D007495:Iridium