The significance of the measurement of serum xanthine oxidase and oxidation markers in patients with acute organophosphorus pesticide poisoning.
This study investigated whether xanthine oxidase (XO) plays an important role in the mechanism of toxicity of acute organophosphorus pesticide poisoning (AOPP). The serum activities of XO, superoxide dismutase (SOD), paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and malondialdehyde (MDA) were compared in 49 patients with AOPP and 50 age- and gender-matched healthy controls. Serum XO and MDA activities were higher and the serum SOD, PON1 and BChE activities were lower in the AOPP patients compared with the controls. Pearson correlation analysis demonstrated a significant negative correlation between XO activity and the SOD, PON1 and BChE activities, but a significant positive correlation between XO activity and MDA. These results suggest that increased activity of XO and decreased antioxidant enzyme activity contribute to the development of oxidative injury in AOPP patients. Thus, effective antioxidant therapy may be a therapeutic option following AOPP.
Zhang
J-W
JW
Clinical Laboratory, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lv
G-C
GC
Zhao
Y
Y
D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D062025:Organophosphate Poisoning; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010575:Pesticides / Q000506:poisoning*; D011041:Poisoning / Q000201:enzymology*; D011379:Prognosis; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D010575:Pesticides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D043303:Aryldialkylphosphatase