A comparison of the effect on QT interval between thiamylal and propofol during anaesthetic induction*.
The aim of this study was to determine the effect of thiamylal and propofol on heart rate-corrected QT (QTc) interval during anaesthetic induction. We studied 50 patients undergoing lumbar spine surgery. Patients were administered 3 microgxkg(-1) fentanyl and were randomly allocated to receive 5 mgxkg(-1) thiamylal or 1.5 mgxkg(-1) propofol as an induction agent. Tracheal intubation was performed after vecuronium administration. Heart rate, mean arterial pressure, bispectral index score, and 12-lead electrocardiogram were recorded at the following time points: just before (T1) and 2 min after (T2) fentanyl administration; 2 min after anaesthetic administration (T3); 2.5 min after vecuronium injection (T4); and 2 min after intubation (T5). Thiamylal prolonged (p < 0.0001), but propofol shortened (p < 0.0001), the QTc interval.
Higashijima
U
U
Staff, Department of Anaesthesia, Nagasaki Rosai Hospital, Sasebo, Japan.
Terao
Y
Y
Ichinomiya
T
T
Miura
K
K
Fukusaki
M
M
Sumikawa
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects* / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced; D007442:Intubation, Intratracheal / Q000379:methods; D008133:Long QT Syndrome / Q000139:chemically induced*; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D015742:Propofol / Q000494:pharmacology*; D013840:Thiamylal / Q000009:adverse effects / Q000494:pharmacology*; D055815:Young Adult
D018686:Anesthetics, Intravenous; D013840:Thiamylal; D015742:Propofol