IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population.
To investigate the association between the potentially functional polymorphisms in IL12A and IL12B, HBV infection and risk of hepatocellular carcinoma in a Chinese population, we genotyped three polymorphisms, rs568408 (3'UTR G>A), rs2243115 (5'UTR T>G) in IL12A and rs3212227 (3'UTR A>C) in IL12B in a case-control study of 869 hepatocellular carcinoma (HCC) cases and 891 cancer-free controls. We found that the IL12A rs568408 GA/AA variant genotypes were associated with a significantly increased risk of HCC (adjusted odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.17-2.00), compared with the wild-type GG homozygote. In the stratified analyses, the increased risk of HCC associated with rs568408 GA/AA was more evident in patients who were negative for HBsAg (adjusted OR = 1.71, 95% CI = 1.23-2.39). However, no significant associations between IL12A rs2243115 T/G, IL12B rs3212227 A/C and risk of HCC were observed. Our findings indicate that IL12A rs568408 may contribute to the risk of HCC and modify HCC risk associated with HBV infection.
Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Li
L
Liu
Yan
Y
Xu
Zheng
Z
Liu
Jianguo
J
Chen
Yixin
Y
Zhang
Jian
J
Zhu
Jibin
J
Liu
Sheng
S
Liu
Guozhong
G
Ji
Haibin
H
Shi
Hongbing
H
Shen
Zhibin
Z
Hu
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics* / Q000821:virology*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000378:metabolism; D006515:Hepatitis B virus / Q000378:metabolism*; D006720:Homozygote; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk
D018664:Interleukin-12