[The immunotropic activity of lupane and oleanane 2,3-seco-triterpenoids].
The immunotropic effect of the 2,3-seco derivatives of allobetulon, betulonic acid, and the methyl ester of betulonic acid were studied. It was found that the highest activity is shown by compounds with an oleanane fragment. The presence of a free C28-carboxyl group enhances the activity of lupeolic 2,3-seco derivatives. A significant contribution to the development of the immune response is introduced by a functional group at the C3 atom in the A ring - the C3-carboxy derivatives intensify the processes of antibody production and alter the number and ratio of leukocyte forms. It is shown that 2,3-seco-1-cyano-19beta,28-epoxy-18alpha-olean-3-oic acid stimulates humoral immunity with a positive influence on hematopoiesis.
Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, ul. Academika Koroleva 3, Perm, 614013 Russia.
L V
LV
Anikina
I A
IA
Tolmacheva
Iu B
IuB
Vikharev
V V
VV
Grishko
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D005260:Female; D056724:Immunity, Humoral / Q000187:drug effects; D007155:Immunologic Factors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D009828:Oleanolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes
D007155:Immunologic Factors; D009828:Oleanolic Acid; D014315:Triterpenes; C480546:lupane; D053978:Pentacyclic Triterpenes