Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
We conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs were carried forward for replication in samples from individuals of the Chinese Han (5,910 cases and 9,916 controls) and Chinese Uygur (713 cases and 824 controls) populations. We identified two independent association signals within the major histocompatibility complex (MHC) region (rs11966200, Pcombined=1.48x10(-48), OR=1.90; rs9468925, Pcombined=2.21x10(-33), OR=0.74). Further analyses suggested that the strong association at rs11966200 might reflect the reported association of the HLA-A*3001, HLA-B*1302, HLA-C*0602 and HLA-DRB1*0701 alleles and that the association at rs9468925 might represent a previously unknown HLA susceptibility allele. We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo.
Quan
Cheng
C
Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui, China.
Ren
Yun-Qing
YQ
Xiang
Lei-Hong
LH
Sun
Liang-Dan
LD
Xu
Ai-E
AE
Gao
Xing-Hua
XH
Chen
Hong-Duo
HD
Pu
Xiong-Ming
XM
Wu
Ri-Na
RN
Liang
Chao-Zhao
CZ
Li
Jia-Bin
JB
Gao
Tian-Wen
TW
Zhang
Jian-Zhong
JZ
Wang
Xiu-Li
XL
Wang
Jun
J
Yang
Rong-Ya
RY
Liang
Ling
L
Yu
Jian-Bin
JB
Zuo
Xian-Bo
XB
Zhang
Sheng-Quan
SQ
Zhang
Shu-Mei
SM
Chen
Gang
G
Zheng
Xiao-Dong
XD
Li
Pan
P
Zhu
Jun
J
Li
Yong-Wei
YW
Wei
Xiao-Dong
XD
Hong
Wei-Song
WS
Ye
Ying
Y
Zhang
Yong
Y
Wu
Wei-Su
WS
Cheng
Hui
H
Dong
Pu-Ling
PL
Hu
Da-Yan
DY
Li
Yang
Y
Li
Min
M
Zhang
Xin
X
Tang
Hua-Yang
HY
Tang
Xian-Fa
XF
Xu
Sheng-Xin
SX
He
Su-Min
SM
Lv
Yong-Mei
YM
Shen
Min
M
Jiang
Hong-Quan
HQ
Wang
Ying
Y
Li
Kai
K
Kang
Xiao-Jing
XJ
Liu
Yu-Qin
YQ
Sun
Li
L
Liu
Zhi-Fang
ZF
Xie
Shao-Qiong
SQ
Zhu
Cheng-Yao
CY
Xu
Qiang
Q
Gao
Jin-Ping
JP
Hu
Wen-Long
WL
Ni
Cheng
C
Pan
Ting-Meng
TM
Li
Yun
Y
Yao
Sha
S
He
Cai-Feng
CF
Liu
Yang-Sheng
YS
Yu
Ze-Ying
ZY
Yin
Xian-Yong
XY
Zhang
Feng-Yu
FY
Yang
Sen
S
Zhou
Youwen
Y
Zhang
Xue-Jun
XJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D014820:Vitiligo / Q000235:genetics*; D055815:Young Adult
D006680:HLA Antigens; D015234:HLA-A Antigens; C541139:HLA-A*30:01 antigen; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains