[Association of regulatory region of HLA-DPB1 with nasopharyngeal carcinoma in southern Chinese Hans].
OBJECTIVE
To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Naso pharyngeal carcinoma in Guangdong Province Hans.


METHODS
The allelic types of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans.


RESULTS
The frequencies of allelic types B/B, haplotype B were higher in patients with NPC than those of the control individuals.


CONCLUSIONS
Positive association may exist between certain HLA-DPB1 alleles and NPC in Guangdong Province Hans.
Department of Otorhinolaryngology-Head and Neck Surgery, the Second Affiliated Hospital, Sun Yat-sen University, China.
Pei
P
Wang
Hua
H
Zou
Lin
L
Ding
Qiujian
Q
Chen
Yiqing
Y
Zheng
Yuping
Y
Wu
Anlong
A
Xu
Yimin
Y
Liu
Yueping
Y
Kong
D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D005787:Gene Frequency; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen