Microcirculatory evaluation in sepsis: a difficult task.
Microcirculatory dysfunction plays a pivotal role in the pathogenesis of severe sepsis and septic shock; hence, microcirculation blood flow monitoring has gained increasing attention. However, microcirculatory imaging is still investigational in human sepsis and has not yet been incorporated into routine clinical practice for several reasons, including the difficult interpretation of microcirculation imaging data, difficulty to draw a parallel between sublingual microcirculation imaging and organ microcirculation dysfunction, as well as the absence of microvessel dysfunction parameters defining sequential microcirculatory changes from the early to late stages of the disease, which could aid in the context of therapeutic approaches and of prognostic parameters. The purpose of this review was to bridge the experimental abdominal organ microvascular derangement kinetics and clinical aspects of microcirculatory findings in the early phase of severe sepsis/septic shock.
Koh
Ivan H J
IH
Department of Surgery, Federal University of São Paulo, São Paulo, Brazil. ivankoh@terra.com.br
Menchaca-Diaz
Jose L
JL
Koh
Tarso H
TH
Souza
Ricardo L
RL
Shu
Christopher M
CM
Rogerio
Victor E
VE
Liberatore
Ana M A
AM
D000818:Animals; D001160:Arterioles / Q000503:physiopathology / Q000648:ultrastructure; D001783:Blood Flow Velocity; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000150:complications; D006801:Humans; D008833:Microcirculation; D018715:Microscopy, Video; D051381:Rats; D018805:Sepsis / Q000209:etiology / Q000503:physiopathology*; D013152:Splanchnic Circulation; D014699:Venules / Q000503:physiopathology / Q000648:ultrastructure; D014781:Viscera / Q000098:blood supply