Comparison between Siriraj mite allergen vaccine and standardized commercial mite vaccine by skin prick testing in normal Thai adults.
House dust mite is a major cause of allergic asthma and rhinitis in Thai population. Skin prick test (SPT) is a useful tool for the diagnosis of the IgE-mediated reactions. The imported commercial mite vaccine for SPT is available but it is relatively expensive. Aim of this study is to compare Siriraj Mite Allergen Vaccine (SMAV) with standardized commercial mite allergen vaccine by skin prick testing in normal Thai adults. A double blind, self-controlled study between the SMAV and standardized commercial mite allergen vaccine was performed by SPT in 17 normal Thai adult males and non-pregnant or non-lactating females aged 18-60 years. The study showed that 35.29 % of non atopic adults had positive SPT reaction to Dp and Df of both SMAV and standardized commercial mite allergen vaccine. Mean wheal and flare diameters from SPT of Dp and Df of SMAV showed strong correlation with standardized commercial mite allergen vaccine (r= 0.768 and 0.897 in Dp and Df respectively, p <0.001). The intraclass correlation was also excellent (0.893 and 0.775 in Dp and Df respectively). There was no significant difference in wheal and flare diameter between SMAV and standardized commercial mite allergen vaccine. No systemic or large local reaction was found in any of the study cases.
Visitsunthorn
Nualanong
N
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. nualanongv@yahoo.com
Pacharn
Punchama
P
Jirapongsananuruk
Orathai
O
Weeravejsukit
Sirirat
S
Sripramong
Chaweewan
C
Sookrung
Nitat
N
Bunnag
Chaweewan
C
D000293:Adolescent; D000328:Adult; D039741:Antigens, Dermatophagoides / Q000008:administration & dosage / Q000191:economics / Q000276:immunology; D045424:Complex Mixtures / Q000008:administration & dosage / Q000191:economics / Q000276:immunology; D017046:Cost Savings; D004311:Double-Blind Method; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000191:economics / Q000276:immunology; D007428:Intradermal Tests / Q000191:economics; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D013785:Thailand
D039741:Antigens, Dermatophagoides; D045424:Complex Mixtures; D011933:Reagent Kits, Diagnostic