[Electron paramagnetic resonance determination of ceruloplasmin concentration in the blood of patients for the diagnosis of urological cancer diseases].
The electron paramagnetic resonance technique was used to study the venous blood levels of ceruloplasmin (CP) in 93 cancer patients with Stages I-IV malignancies of the urinary bladder and kidneys. Two groups were selected as a control; one of them comprised 44 donors who were considered to be apparently healthy and the other included 32 outpatients, some of whom had noncancer diseases. It has been established that in urological cancer, the level of the paramagnetic phase of Cu2+ -CP may vary in the wide range: from the lower to exceeding upper normal range in noncancer disease. The content of Cu2+ -CP does not virtually depend on the site and differentiation of a tumor. A correlation between the blood concentration of Cu2+ -CP and erythrocyte sedimentation rate (ESR) in urological cancer patients has been considered. Determination of CP levels at the ESR exceeding the normal values may be expedient for the early diagnosis of cancer and also an addition to the biological individual screening of patients in the preoperative period to choose the correct and effective treatment tactics.
M I
MI
Ibragimova
A I
AI
Chushnikov
V N
VN
Moiseev
V Iu
VIu
Petukhov
E P
EP
Zheglov
V I
VI
Pogorel'tsev
N B
NB
Khardina
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014571:Urologic Neoplasms / Q000097:blood* / Q000175:diagnosis*
D003300:Copper; D002570:Ceruloplasmin