A highly effective gene delivery vector--hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP.
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.
Network of Excellence for Functional Biomaterials, National University of Ireland Galway, Galway, Ireland.
Ben
B
Newland
Hongyun
H
Tai
Yu
Y
Zheng
Diego
D
Velasco
Andrea
A
Di Luca
Steven M
SM
Howdle
Cameron
C
Alexander
Wenxin
W
Wang
Abhay
A
Pandit
D016475:3T3 Cells; D000818:Animals; D050091:Dendrimers / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D009757:Nylons / Q000737:chemistry*; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D011095:Polyethylenes / Q000737:chemistry; D014162:Transfection
D050091:Dendrimers; D007097:Imines; D008689:Methacrylates; D009757:Nylons; D011095:Polyethylenes; C407037:poly(2-(dimethylamino)ethyl methacrylate); C505405:poly(ethylene imine)