6'-Hydroxy-3'-methoxy-mitorubrin, a new potentiator of antifungal miconazole activity, produced by Penicillium radicum FKI-3765-2.
A new mitorubrin congener designated 6'-hydroxy-3'-methoxy-mitorubrin (1) was isolated along with structurally related 4'-hydroxy-3'-methoxy-(S)-mitorubrin (2) and monomethyl-(S)-mitorubrin (3) from the culture broth of Penicillium radicum FKI-3765-2 by solvent extraction, octadecyl silyl (ODS) column chromatography and HPLC. The structure of 1 was elucidated by various spectral analyses, including NMR experiments. They have a common isochromane-like ring with a similar hydrophobic side chain. These compounds moderately potentiated miconazole activity against Candida albicans.
Graduate School of Pharmaceutical Sciences, Kitasato University.
Hiroyuki
H
Yamazaki
Satoshi
S
Omura
Hiroshi
H
Tomoda
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000378:metabolism*
D000935:Antifungal Agents; D001565:Benzoates; C521221:mitorubrin