Fatal allopurinol-induced hypersensitivity syndrome associated with pancreatic abnormalities.
Allopurinol hypersensitivity syndrome is a severe adverse reaction characterized by rash, fever, and internal organ involvement. We report a case of fatal allopurinol-induced hypersensitivity syndrome associated with acute pancreatitis.A 46-year-old man was treated by allopurinol for asymptomatic hyperuricemia. The patient developed a diffuse erythrodermic maculopapular eruption and fever. Laboratory analysis revealed cytolysis and cholestasis, amylases and lipases were highly elevated. Computed tomography scans revealed pancreatitis Grade C. The treatment of asymptomatic hyperuricemia should only be initiated when there is a clear indication to reduce the incidence and the severe consequences of allopurinol hypersensitivity syndrome.
Fathallah
Neila
N
Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Sousse, Tunisia. neilafathallah@gmail.com
Ben Salem
Chaker
C
Slim
Raoudha
R
Kaabia
Naoufel
N
Letaief
Amel
A
Bouraoui
Kamel
K
D000493:Allopurinol / Q000009:adverse effects*; D003875:Drug Eruptions / Q000150:complications / Q000209:etiology*; D017809:Fatal Outcome; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced* / Q000150:complications
D006074:Gout Suppressants; D000493:Allopurinol