Long-term outcome of living donors older than 60 years.
Long-term outcomes of renal transplantation using kidneys from donors >60 years old are generally considered to be poor. This retrospective study included 265 living donor (LD) transplants in adult recipients with a mean follow-up of 13.1 +/- 6.1 years (range, 1.3-25.8), all of them under CNI. They were grouped according to the donor age at least (n = 49) or less (n = 216) than 60 years. Graft and patient survivals were compared using the Kaplan-Meier method and Cox multiple regression. At 1, 3, and 10 years, postoperatively patient survivals in the group of older LD recipients were 97%, 96%, and 93%, versus 98%, 97% and 92% among the younger LD recipients. At 1, 3 and 10 years, postoperatively graft survivals uncensored for death were 94%, 92%, and 81% among the older LD recipients versus 93%, 89%, 75% among the control group, respectively, despite a slightly increased creatininemia observed at 10 years among the older LD recipients. Deaths censored graft survivals were 96%, 96%, and 87% among the older versus 94%, 91% and 78% among the younger LD recipients, respectively. Therefore, significantly better noncensored death-censored graft survivals, were observed among the recipients of older LD compared with recipients of the younger donor group.
General Surgery and Kidney Transplantation Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. luisa.berardinelli@unimi.it
L
L
Berardinelli
E
E
Pozzoli
C
C
Beretta
D
D
Consonni
M
M
Carini
G
G
Rossini
M
M
Scalamogna
D000017:ABO Blood-Group System; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology* / Q000706:statistics & numerical data; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D015996:Survival Rate; D017741:Survivors; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics; D013997:Time Factors
D000017:ABO Blood-Group System; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate