How to train your biomarker.
Type I insulin-like growth factor (IGF) receptor (IGF1R) inhibitors are new cancer therapies. Pitts and colleagues used in vitro data to "train" a predictive biomarker for an IGF1R tyrosine kinase inhibitor. Given the complexity of IGF signaling, additional layers of biomarker analysis will likely be needed to develop predictive factors.
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. yeexx006@umn.edu
Douglas
D
Yee
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D020869:Gene Expression Profiling; D006801:Humans; D008024:Ligands; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D008024:Ligands; D047428:Protein Kinase Inhibitors; D017526:Receptor, IGF Type 1