Changes in cardiac pumping efficiency and intra-thoracic organ volume during negative pressure wound therapy of sternotomy wounds, assessment using magnetic resonance imaging.
Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation.
Department of Ophthalmology, Lund University Hospital, Lund, Sweden.
Christian
C
Torbrand
Martin
M
Ugander
Henrik
H
Engblom
Göran K
GK
Olivecrona
Olof
O
Gålne
Håkan
H
Arheden
Richard
R
Ingemansson
Malin
M
Malmsjö
D000818:Animals; D002302:Cardiac Output / Q000502:physiology*; D002306:Cardiac Volume / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D008297:Male; D054843:Negative-Pressure Wound Therapy; D056346:Sternotomy / Q000009:adverse effects*; D034421:Sus scrofa; D035423:Thoracic Cavity / Q000293:injuries* / Q000503:physiopathology*; D014945:Wound Healing