Design and biological evaluation of biphenyl-4-carboxylic acid hydrazide-hydrazone for antimicrobial activity.
Seven biphenyl-4-carboxylic acid hydrazide-hydrazones have been synthesized. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger All newly synthesized compounds exhibited promising results.
Deep
Aakash
A
Department of Pharmaceutical Sciences, G.V.M. College of Pharmacy, Sonepat-131001, India. aakashdeep82@gmail.com
Jain
Sandeep
S
Sharma
Prabodh Chander
PC
Verma
Prabhakar
P
Kumar
Mahesh
M
Dora
Chander Parkash
CP
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D015195:Drug Design; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001713:Biphenyl Compounds; D002264:Carboxylic Acids; D006834:Hydrazines; D006835:Hydrazones