High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes mellitus.
The elevated level of high-sensitivity C-reactive protein (HSCRP) is associated with cognitive dysfunction, for which changes in the hippocampus plausibly play a pivotal role. We tested the hypothesis that an elevated level of HSCRP correlates with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes mellitus. Subjects included 45 nondementia patients with type 2 diabetes mellitus, who were divided into 2 groups: high-HSCRP group (age, 65 ± 6 years [mean ± SD]; n = 17) and normal-HSCRP group (65 ± 7 years, n = 28). Hippocampus volume has been quantitated with computer-assisted analysis using a magnetic resonance imaging voxel-based specific regional analysis system developed for the study of Alzheimer disease (VSRAD), which yields a z score as the end point for assessment of hippocampal volume. The z score was higher in the high-HSCRP group than in the normal-HSCRP group (P < .0001). The fasting plasma glucose (P < .05) and insulin concentrations (P < .0001) and the homeostasis model assessment (HOMA) index (P < .0001) were higher in the high-HSCRP group than in the normal-HSCRP group. Multiple regression analysis showed that HSCRP levels were independently predicted by z score and HOMA index. Our results indicate that the elevated level of HSCRP in Japanese nondementia patients with type 2 diabetes mellitus is characterized by increased hippocampus volume and insulin resistance, and that the z score and HOMA index are independent predictors of HSCRP.
Department of Cardiology, Oita Red Cross Hospital, Oita 870-0033, Japan. anan-f@med.oita-u.ac.jp
Futoshi
F
Anan
Takayuki
T
Masaki
Tsuyoshi
T
Shimomura
Minoru
M
Fujiki
Yoshikazu
Y
Umeno
Nobuoki
N
Eshima
Tetsunori
T
Saikawa
Hironobu
H
Yoshimatsu
D000368:Aged; D015992:Body Mass Index; D001921:Brain / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D003071:Cognition / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology* / Q000523:psychology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis
D007328:Insulin; D002097:C-Reactive Protein