Effect of morselized bones on binding of the canine hydroxyapatite-coated femoral stem.
BACKGROUND
Non-cement femoral stems are recognized in clinical use, but there are still some problems. The aim of this research was to make non-cement femoral stems to be press-fit with the medullary cavity.


METHODS
Twenty-four healthy adult mongrel dogs were randomly divided into experimental and control groups. In the right hip joint, an artificial femoral bone replacement surgery was conducted. For the experimental group, the replacement surgery of hydroxyapatite (HA)-coated femoral stems was done, while autogeneous morselized bone was implanted into the medullary cavity. For the control group, morselized bone was not implanted. At postoperative 1, 3, 6 months, a test for interfacial shear characteristics was conducted in the MTS810 Tester. The comparison between the two groups' bone-prostheses in shear strength for their interface from shearing destruction was made. A histological observation to check prosthesis-bone interface contact ratios and bone growth was carried out.


RESULTS
For the experimental group, shear strength was 0.317 MPa in 1 month, 1.447 MPa in 3 months, and 1.621 MPa in 6 months. For the control group, shear strength was 0.195 MPa in 1 month, 1.023 MPa in 3 months, and 1.483 MPa in 6 months. The difference was statistically significant. Stereomicroscope-based observation showed that the number of trabecular bones in the experimental group was larger than that of the control group, and bone growth of the former group was better than that of the latter group. Inverted microscopic observation showed that the binding degree between the prosthesis and trabecular bone of the experimental group was higher than that of the control group. Comparatively, the experimental group's trabecular bone had more stromal cells.


CONCLUSIONS
The morselized bones can effectively improve the biological bonding strength and bone-contact ratios in the short term for the HA-coated femoral stem and accelerate the bonding process. The use of morselized autogenous bones played a good role in bone in-growth of the femoral bone stem surface.
Department of Orthopaedic Surgery, First Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
Ke-guan
KG
Song
De-heng
DH
Ma
Jian-wen
JW
Hou
Huan
H
Wang
Jing-long
JL
Yan
Zhan-ge
ZG
Yu
Zhi-zhong
ZZ
Liang
D000818:Animals; D001696:Biomechanical Phenomena; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery*; D008297:Male; D016348:Osseointegration; D011897:Random Allocation; D033081:Shear Strength
D020099:Coated Materials, Biocompatible; D017886:Durapatite