Rapid detection of Trypanosoma cruzi in human serum by use of an immunochromatographic dipstick test.
We evaluated a commercially available immunochromatographic dipstick test to detect Trypanosoma cruzi infection in 366 human serum samples with known serological results from Argentina, Ecuador, Mexico, and Venezuela. One hundred forty-nine of 366 (40.7%) and 171/366 (46.7%) samples tested positive by dipstick and serology, respectively. Dipstick sensitivity was calculated to be 84.8% (range between countries, 77.5 to 95%), and specificity was 97.9% (95.9 to 100%).
Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom. rreithinger@yahoo.co.uk
Richard
R
Reithinger
Mario J
MJ
Grijalva
Rosa F
RF
Chiriboga
Belkisyolé Alarcón
BA
de Noya
Jaime R
JR
Torres
Norma
N
Pavia-Ruz
Pablo
P
Manrique-Saide
Marta V
MV
Cardinal
Ricardo E
RE
Gürtler
D001118:Argentina; D014355:Chagas Disease / Q000175:diagnosis* / Q000469:parasitology; D004484:Ecuador; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008800:Mexico; D010274:Parasitology / Q000379:methods*; D012680:Sensitivity and Specificity; D044967:Serum / Q000469:parasitology*; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000276:immunology / Q000302:isolation & purification*; D014687:Venezuela