Treatment failure, recurrence, and antibiotic prescription rates for different acute otitis media treatment methods.
In an era of increasing antibiotic resistance, reliance on empirical antibiotic therapy for management of acute otitis media (AOM) will eventually become an untenable strategy. New research efforts are needed to identify effective treatment alternatives. In this retrospective analysis, we assessed AOM treatment failure (AOMTF), recurrent AOM (RAOM), and antibiotic prescription rates for groups of AOM episodes managed with either immediate antibiotics (ABX), tympanocentesis + observation (Tap + OBS), or tympanocentesis + immediate antibiotics (Tap + ABX). No significant differences in rates of AOMTF or RAOM were observed between any of the treatment groups. The 30-day rate of antibiotic prescriptions written for AOM was significantly lower in the TAP + OBS group (1 prescription per 3.8 episodes) than in the immediate antibiotic therapy groups (1.2 prescriptions per episode), P < .001. The comparative risk of AOMTF was slightly higher among AOM episodes caused by Streptococcus pneumoniae (OR 2.523; CI 1.070-5.944; P = 0.056). Neither the presence of other particular otopathogens, nor the presence of drug-resistant otopathogens, nor the choice of any particular AOM antibiotic therapy correlated with increased risk of either AOMTF or RAOM. The observed absence of significant differences in clinical outcomes between the various treatment groups in this study is consistent with findings published by other authors: alternative AOM therapies can help reduce reliance on antibiotics without inviting significant increases in rates of clinical failure.
Grubb
Mark S
MS
Woodcreek Healthcare Inc, Puyallup, WA 98371, USA. mgrubb@u.washington.edu
Spaugh
David C
DC
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D019370:Observation; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D019152:Paracentesis; D012189:Retrospective Studies; D055502:Secondary Prevention; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013997:Time Factors; D017211:Treatment Failure; D014432:Tympanic Membrane / Q000382:microbiology / Q000601:surgery*
D000900:Anti-Bacterial Agents