Early cognitive impairment in a subset of patients with presumed low-grade glioma.
We investigated the presence of cognitive impairment, in adults with presumed low-grade glioma at early stage of disease prior to major treatments, in relation to neurological symptoms and radiological characteristics of the tumour. Sixteen patients were evaluated. A subset of patients was identified with clearly impaired cognition. Patients with cognitive impairment often had large tumours in the left frontal lobe, were relatively young, and most of them were males. We conclude that cognitive dysfunction may be present already at early stage of disease, and that early identification of patients at risk is warranted.
Ek
Lena
L
Department of Psychology, Stockholm University, Stockholm, Sweden. lena-birgitta.ek@telia.com
Almkvist
Ove
O
Wiberg
Maria Kristoffersen
MK
Stragliotto
Giuseppe
G
Smits
Anja
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology / Q000523:psychology; D016022:Case-Control Studies; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005910:Glioma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors