Recent applications of a synthetic model of cytochrome c oxidase: beyond functional modeling.
This account reports recent developments of a functional model for the active site of cytochrome c oxidase (CcO). This CcO mimic not only performs the selective four-electron reduction of oxygen to water but also catalytically reduces oxygen using the biological one-electron reductant, cytochrome c. This functional model has been used to understand other biological reactions of CcO, for example, the interaction between the gaseous hormone, NO, and CcO. A mechanism for inactivating NO-CcO complexes is found to involve a reaction between oxygen and Cu(B). Moreover, NO is shown to be capable of protecting CcO from toxic inhibitors such as CN(-) and CO. Finally, this functional CcO model has been used to show how H(2)S could induce hibernation by reversibly inhibiting the oxygen binding step involved in respiration.
Department of Chemistry, Stanford University, Stanford, California 94305, USA. jpc@stanford.edu
James P
JP
Collman
Somdatta
S
Ghosh
D040761:Biomimetic Materials / Q000737:chemistry; D020134:Catalytic Domain; D045304:Cytochromes c / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
D007093:Imidazoles; D009942:Organometallic Compounds; D011166:Porphyrins; D045304:Cytochromes c; D003576:Electron Transport Complex IV