Anti-ischemia steroidal saponins from the seeds of Allium fistulosum.
Six new furostanol saponins (1-6), named fistulosaponins A-F, three known furostanol saponins (7-9), and seven known aromatic compounds were isolated from seeds of Welsh onion (Allium fistulosum). The structures of these compounds were characterized by spectroscopic analyses including 2D NMR spectroscopy, mass spectrometry, and acid hydrolysis. The protective effect of the saponins on hypoxia-induced human umbilical vein endothelial cell injury was evaluated.
Lai
Wei
W
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415#, Shanghai 200003, People's Republic of China.
Wu
Zhijun
Z
Lin
Houwen
H
Li
Tiejun
T
Sun
Lianna
L
Chai
Yifeng
Y
Chen
Wansheng
W
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019697:Onions / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D012503:Saponins; D013261:Sterols