Visual sensory processing deficit in the occipital region in children with attention-deficit / hyperactivity disorder as revealed by event-related potentials during cued continuous performance test.
OBJECTIVE
Recent studies described several changes of attention-related components of late frontal event-related potentials (ERPs) during Go/NoGo paradigm in children with attention-deficit/hyperactivity disorder (ADHD). We aimed to determine whether ERP components corresponding to earlier encoding of visual incoming information are also modulated by attentional disorders.


METHODS
We recorded high-resolution EEG in 15 children meeting DSM-IV criteria for ADHD, comprising 15 age-matched control groups during an equiprobable Go/NoGo task in a cued continuous performance test (CPT-AX) paradigm. Both P100 and N200 ERP components were measured in response to both Go and NoGo stimuli. We analyzed both components with SwLORETA in order to localize their brain sources.


RESULTS
A low rate of Go correct response and high rate of omission errors were observed in ADHD children. When compared to controls, these displayed delayed P100 and N200 latency, and lower P100-NoGo amplitude. In addition, the P100 latency was delayed for NoGo compared to Go condition. The source of P100 was located in occipital area. A sizable decrease in early electrical activity was found in ADHD, especially in the NoGo condition.


CONCLUSIONS
Our results suggest an early deficit in visual sensory integration within the occipital cortex in children with ADHD.
Université de Picardie, CHU d'Amiens, Amiens, France. nazaripsycho@yahoo.com
M A
MA
Nazari
P
P
Berquin
P
P
Missonnier
A
A
Aarabi
D
D
Debatisse
A
A
De Broca
F
F
Wallois
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology* / Q000523:psychology; D001931:Brain Mapping; D002648:Child; D003463:Cues; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000503:physiopathology*; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*