Influence of body mass index on outcome of pediatric chronic hepatitis C virus infection.
OBJECTIVE
Evidence demonstrates that obesity is associated with progression of chronic hepatitis C virus (HCV) infection and poor response to interferon therapy among HCV-infected adults. However, this evidence has been confounded by multiple comorbidities present in adult cohorts and the use of single adult doses.


METHODS
We performed a retrospective investigation to evaluate the role of body mass index (BMI) in chronic HCV progression and response to therapy in the children. One hundred twenty-three children and teenagers studied at Children's Hospital Boston for HCV infection between 1998 and 2007 were included. Patients' weight and height at the time of liver biopsy or before and after HCV therapy were obtained and BMI was calculated.


RESULTS
The presence of steatosis was statistically associated with higher mean (+/-SE) BMI percentiles (72nd +/- 5.8 vs 58th +/- 3.5) percentile; F(1,101) = 4.2, P = 0.04. Nonresponders to treatment had a higher mean (+/-SE) BMI percentile (70th +/- 7.4) when compared with responders (50th +/- 6.5) in univariate and multivariate analyses (P = 0.04, P = 0.02, respectively). Using a multivariate model, it was calculated that 1 standard deviation (1 z-score unit) increase in baseline BMI z score is associated with a 12% decrease in the probability of sustained virologic response.


CONCLUSIONS
Overweight adversely affects the progression of chronic HCV liver disease and is associated with diminished response to antiviral therapy using weight-based dosing in a cohort with minimal comorbidities.
Delgado-Borrego
Aymin
A
Division of Clinical Research, Department of Pediatrics, Batchelor Children's Research Institute, University of Miami, Miami, FL, USA.
Healey
David
D
Negre
Betania
B
Christofi
Marielle
M
Sabharwal
Sabina
S
Ludwig
David A
DA
Chung
Raymond T
RT
Jonas
Maureen M
MM
D000293:Adolescent; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015992:Body Mass Index; D002648:Child; D018450:Disease Progression; D024882:Drug Resistance, Viral; D005234:Fatty Liver / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D005260:Female; D016174:Hepacivirus / Q000187:drug effects*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008297:Male; D015233:Models, Statistical; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications*; D012189:Retrospective Studies
D000998:Antiviral Agents