Autoantibodies to coagulation factors.
Tolerance to autoantigens such as coagulation factors is the result of censoring mechanisms occurring at the level of the thymus and bone marrow for autoreactive T and B cells, respectively. In addition, peripheral mechanisms, both intrinsic and extrinsic further control activation of autoreactive cells that have escaped central deletion. Emergence of autoimmunity can occur from disturbances of these control mechanisms by a number of events, many of which are incompletely understood. Insight into this clinically important field is expected from exploitation of recent animal models.
Center for Molecular and vascular Biology, Campus Gasthuisberg, University of Leuven, Leuven, Belgium. jeanmarie.saint-remy@med.kuleuven.ac.be
J-M R
JM
Saint-Remy
D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity; D005169:Factor VIII / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D005169:Factor VIII