Special delivery for MHC II via autophagy.
In this issue of Immunity, Blanchet et al. (2010) report that human immunodeficiency virus-1 inhibits macroautophagy in dendritic cells, attenuating MHC II presentation. Lee et al. (2010) previously revealed the requirement of autophagic machinery for MHC II presentation of herpes viral antigens.
Hayward
Andrew P
AP
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.
Dinesh-Kumar
S P
SP