Regenerative medicine applied to solid organ transplantation: where do we stand?
The objective of regenerative medicine (RM) and Tissue Engineering (TE) is to create living functional tissues to repair or replace tissues or organ functions. This field holds the promise of regenerating damaged tissues and organs in the body. It has the potential to solve the problems of organ shortage and of toxicities deriving from life-long immunosuppression. In fact, cells in the regenerated organ would match those of the patient, from whom they would normally be derived. In the past decade, RM/TE has achieved striking results which are of interest to the transplant community. However, major roadblocks on the avenue to full success include the need for a deeper understanding of cell biology and of interactions with the extracellular matrix. We are presently not able to grow and expand cells indefinitely and safely in various scenarios where RM/TE may be indicated. The production of adequately vascularized scaffolds to optimize nutrients and oxygen delivery, assessment of the viability and function of the cells in the bioengineered construct, and the costs remain areas of scientific research.
Orlando
G
G
Renal Failure and Transplant Surgery, University of L'Aquila, L'Aquila, Italy. gorlando@wfubmc.edu
Di Cocco
P
P
D'Angelo
M
M
Clemente
K
K
Famulari
A
A
Pisani
F
F
D000328:Adult; D000818:Animals; D057005:Bioengineering / Q000379:methods; D001808:Blood Vessels / Q000637:transplantation; D016922:Cellular Senescence; D030342:Genetic Diseases, Inborn / Q000601:surgery; D006801:Humans; D016377:Organ Transplantation / Q000379:methods* / Q000639:trends; D011651:Pulmonary Artery / Q000637:transplantation; D012038:Regeneration / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods / Q000639:trends; D001743:Urinary Bladder / Q000166:cytology / Q000502:physiology / Q000637:transplantation; D001745:Urinary Bladder Diseases / Q000601:surgery