Efficacy of a surgical scrub including 2% chlorhexidine acetate for canine superficial pyoderma.
The clinical efficacy of a surgical scrub containing 2% chlorhexidine acetate (2CA; Nolvasan® Surgical Scrub; Fort Dodge Animal Health, USA) was evaluated for the topical management of canine superficial pyoderma. The first study was a randomized, double-blind, controlled trial. The control was a shampoo containing 4% chlorhexidine gluconate (4CG; Skin Clinic Shampoo; CHD MEDICS, Goyang, Korea). Ten dogs with symmetrical lesions of canine superficial pyoderma were allocated to receive either 2CA or the control shampoo applied to either side of the body twice weekly for 1 week. Both the owners and the investigators subjectively scored skin lesions including pruritus, erythema, crusted papules and scales on a scale of 0-3. The 2CA and 4CG resulted in almost the same degree of improvement of skin lesions, and there were no significant differences between the two groups. The second study was an open trial of 2CA monotherapy in eight dogs with cefalexin-resistant Staphylococcus intermedius group-associated superficial pyoderma. The 2CA monotherapy was applied every 2 days for 2 weeks. Five dogs improved with 2CA monotherapy, one partially improved and two did not. No adverse reactions were seen in either trial. This suggests that a 2CA surgical scrub could be a useful and safe topical adjunct therapy for dogs with superficial pyoderma involving cefalexin-resistant Staphylococcus intermedius group.
Animal Dermatology Center, ASC, Tokyo, Japan. murayama@asc.jp
Nobuo
N
Murayama
Masahiko
M
Nagata
Yuri
Y
Terada
Sanae
S
Shibata
Tsuneo
T
Fukata
D000287:Administration, Topical; D000818:Animals; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D008297:Male; D011711:Pyoderma / Q000188:drug therapy / Q000662:veterinary*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy / Q000662:veterinary; D057789:Staphylococcus intermedius / Q000187:drug effects; D016896:Treatment Outcome
C010882:chlorhexidine gluconate; D002710:Chlorhexidine