IgG₄-related sclerosing disease: a novel mimic of inflammatory bowel disease.
High levels of IgG₄-positive plasma cells are commonly seen in autoimmune pancreatitis. It has recently become evident that autoimmune pancreatitis is one component of a larger multi-system disease. IgG₄-positive plasma cells have been identified in many extrapancreatic tissues, including the colon, biliary tract, liver, and lungs, and thus the term "IgG₄-related sclerosing disease" has been proposed. Awareness of IgG₄-related sclerosing disease is important, as it has been shown to mimic other conditions like malignancy. This review discusses IgG₄-related colitis and its potential for mimicking inflammatory bowel disease.
Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.
Neeraj
N
Narula
Monica
M
Vasudev
John K
JK
Marshall
D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000276:immunology*; D003424:Crohn Disease / Q000453:epidemiology / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D010195:Pancreatitis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000453:epidemiology; D010950:Plasma Cells / Q000276:immunology; D015995:Prevalence; D012598:Sclerosis
D007074:Immunoglobulin G