Serum total adiponectin is associated with impaired glucose tolerance in Asian Indian females but not in males.
OBJECTIVE
Adiponectin may play a role in the development of type 2 diabetes and cardiovascular disease (CVD). However, little is known about the relationship between adiponectin and impaired glucose tolerance (IGT). We investigated the association between adiponectin and IGT and between adiponectin and cardiovascular risk factors among subjects with IGT.


METHODS
Subjects with normal glucose tolerance (NGT)(n = 571) and impaired glucose tolerance (n = 167) were recruited from the Chennai Urban Rural Epidemiology Study in south India. Serum total adiponectin levels were measured using a radioimmunoassay (Linco Research, St. Charles, MO). High sensitivity C-reactive protein (hsCRP) was estimated by nephelometry.


RESULTS
In sex-stratified analyses, adiponectin was significantly associated with IGT in females [odds ratio (OR): 0.93, 95% confidence interval (CI): 0.872-0.991, p = 0.026] after controlling for age, waist circumference, blood pressure, alcohol consumption, smoking, lipid profile, and glycemic indices; in males there was no significant association (OR = 0.90, 95% CI: 0.798-1.012, p = 0.078). In prediabetic females, adiponectin was not associated with any CVD risk factors (age, waist circumference, blood pressure, cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, fasting glucose, fasting insulin, and insulin resistance level), but was associated negatively with 2-hour postplasma glucose levels (r = -0.243, p < 0.05) and hsCRP (r = -0.219, p < 0.05) after adjusting for demographic and biomedical indices. No associations with CVD risk factors were observed in males with IGT.


CONCLUSIONS
Serum total adiponectin levels are associated with IGT, 2-hour postplasma glucose, and hsCRP in Asian Indian females but not in males.
Nutrition and Health Science Program, Graduate School of Arts and Sciences, Emory University, Atlanta, Georgia, USA.
Menghua
M
Luo
Reena
R
Oza-Frank
K M Venkat
KM
Narayan
Kuppan
K
Gokulakrishnan
Viswanathan
V
Mohan
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*; D012737:Sex Factors
D052242:Adiponectin; D001786:Blood Glucose; D002097:C-Reactive Protein