[Analysis of 62 cases of nosocomial staphylococcal meningitis admitted to the Iaşi Hospital of Infectious Diseases over a period of 21 years].
OBJECTIVE
To analyze the clinical features, evolution and treatment of nosocomial staphylococcal meningitis admitted to Hospital of Infectious Diseases Iaşi between 1988 and 2007.


METHODS
The data were gathered from the archive of Hospital of Infectious Diseases Iaşi. We studied the clinical and laboratory features of 62 cases of nosocomial staphylococcal meningitis admitted in the study period.


RESULTS
The development of nosocomial meningitis was subsequent to interventions on the central nervous system for haematoma, ventriculo-peritoneal shunts, tumors, spinal anesthesia. The symptoms were fever, headache, stiff neck and vomiting. The etiological agents were: Staphylococcus aureus 37 in cases and coagulase negative staphylococci in 25 cases. The treatment was according to their susceptibility rates, using systemic quinolones and ceftazidime or colymicin. The evolution was favorable in 52 patients and unfavorable in another 10.


CONCLUSIONS
Nosocomial staphylococcal meningitis remains a serious condition due to the fact that the etiological agents are resistant to the classical antistaphylococcal antibiotics and increasingly resistant to methicillin.
Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi Facultatea de Medicină, Disciplina de Boli infectioase.
Cătălina
C
Logigan
Doina
D
Mihalache
Olivia
O
Dorneanu
Tatiana
T
Turcu
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002442:Ceftazidime / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003091:Colistin / Q000627:therapeutic use; D003428:Cross Infection / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D055819:Hospitals, Isolation; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015363:Quinolones / Q000627:therapeutic use; D012189:Retrospective Studies; D012383:Romania; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D013210:Staphylococcus / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D015363:Quinolones; D002442:Ceftazidime; D003091:Colistin