Novel topical therapeutics.
Intranasal drug delivery is a rapidly growing field that offers the potential for enhanced treatment of local and systemic disease. Novel preclinical screening tools such as in vitro assays and 3-dimensional imaging are currently being used to improve drug design and delivery. In addition, new evidence has emerged underlining the importance of surgical marsupialization of the sinuses to allow for improved topical delivery. Although multiple barriers to administration and absorption exist, implantable therapeutics using new classes of drug-eluting polymers allow for prolonged, site-specific drug delivery and hold great promise in overcoming these obstacles.
Bleier
Benjamin S
BS
Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC 29425, USA. bleierb@gmail.com
D000287:Administration, Topical; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D009079:Mucociliary Clearance; D009093:Mucus; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000187:drug effects; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000187:drug effects / Q000601:surgery; D049268:Positron-Emission Tomography; D019919:Prosthesis Implantation