Transfer hydrogenation in water: enantioselective, catalytic reduction of alpha-cyano and alpha-nitro substituted acetophenones.
Catalytic reduction of alpha-substituted acetophenones under conditions involving asymmetric transfer hydrogenation in water is described. The reaction is conducted in water and open to air, and formic acid is used as reductant.
Soltani
Omid
O
Laboratorium für organische Chemie, ETH Zürich, Hönggerberg, Switzerland.
Ariger
Martin A
MA
Vázquez-Villa
Henar
H
Carreira
Erick M
EM
D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005561:Formates / Q000737:chemistry; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D000098:Acetophenones; D005561:Formates; D009942:Organometallic Compounds; D014867:Water; C030544:formic acid; D007495:Iridium