Quantitative analysis of a urine-based assay for detection of lipoarabinomannan in patients with tuberculosis.
Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Maunank
M
Shah
Neil A
NA
Martinson
Richard E
RE
Chaisson
Desmond J
DJ
Martin
Ebrahim
E
Variava
Susan E
SE
Dorman
D000328:Adult; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000652:urine*; D008297:Male; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000175:diagnosis* / Q000473:pathology; D014556:Urine / Q000737:chemistry*
D008070:Lipopolysaccharides; C050016:lipoarabinomannan