Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population.
To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR)=1.12, P=0.01).
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. k-chieko@umin.ac.jp
Chieko
C
Kyogoku
Masaya
M
Yanagi
Kunihiro
K
Nishimura
Daisuke
D
Sugiyama
Akio
A
Morinobu
Masaaki
M
Fukutake
Kiyoshi
K
Maeda
Osamu
O
Shirakawa
Takayoshi
T
Kuno
Shunichi
S
Kumagai
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D019703:Calcineurin / Q000235:genetics*; D016022:Case-Control Studies; D003431:Cross-Cultural Comparison; D051776:Early Growth Response Protein 3 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C079945:EGR3 protein, human; D051776:Early Growth Response Protein 3; D019703:Calcineurin; C525675:PPP3CC protein, human