Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules.
The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.
Cheng
Shuk-Yan
SY
Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
Yuen
Marcus Chun-Wah
MC
Lam
Pik-Ling
PL
Gambari
Roberto
R
Wong
Raymond Siu-Ming
RS
Cheng
Gregory Yin-Ming
GY
Lai
Paul Bo-San
PB
Tong
See-Wai
SW
Chan
Kit-Wah
KW
Lau
Fung-Yi
FY
Kok
Stanton Hon-Lung
SH
Lam
Kim-Hung
KH
Chui
Chung-Hin
CH
D000068579:Celecoxib; D048271:Chitosan / Q000138:chemical synthesis* / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D048271:Chitosan; D000068579:Celecoxib