[Synchroton radiotherapy].
Radiation therapy is commonly used in the treatment of cancer. The normal tissue tolerance can be a limit to deliver enough dose to the tumor to be curative. The synchrotron beam presents some interesting physical properties, which could decrease this limitation. Synchrotron beam is a medium energy X-ray nearly parallel beam with high intensity. Three methods are under preclinical investigations: the microbeam, the minibeam and the stereotactic radiotherapy. The first two use a geometric irradiation effect called spatial fractioning. The last one use highly conformational irradiation geometry combined with a dose enhancement due to the presence of high-Z element in the target. Synchrotron radiotherapy preclinical experiments have shown some curative effect on rodent glioma models. Following these encouraging results a phase I/II clinical trial of iodinated enhanced stereotactic synchrotron radiotherapy is currently being prepared at the European Synchrotron Radiation Facility.
Inserm, U836, équipe 6, Université Joseph-Fourier, BP 51, 38041 Grenoble cedex 9, France.
P
P
Deman
M
M
Edouard
S
S
Besse
M
M
Vautrin
H
H
Elleaume
J-F
JF
Adam
F
F
Estève
D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011878:Radiotherapy / Q000379:methods; D013238:Stereotaxic Techniques; D017356:Synchrotrons