A prospective study of febrile episodes in inpatient children on chemotherapy.
In 538 febrile episodes in 188 children enrolled prospectively, 62% of children were neutropenic and 86% had infection-related fever. Respiratory infection was the commonest febrile cause (60%). Bacteremia occurred more often in neutropenic than non-neutropenic episodes (20% vs. 3%) and was accompanied significantly more with shiver, lassitude, and decreased dorsum pedis pulse. About 65% of blood isolates were Gram-negative bacilli, which differs from the observations in western countries.
Department of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zhi-Yong
ZY
Ke
Ling
L
Xu
Ting-Ting
TT
Zhang
Ying-Lei
YL
Mo
Li-Bin
LB
Huang
Xiao-Li
XL
Zhang
Xue-Qun
XQ
Luo
D000293:Adolescent; D016470:Bacteremia / Q000453:epidemiology / Q000473:pathology; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D004358:Drug Therapy / Q000379:methods*; D005260:Female; D005335:Fever of Unknown Origin / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy*; D009503:Neutropenia / Q000175:diagnosis / Q000453:epidemiology; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000453:epidemiology