Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation.
Rheumatoid arthritis (RA) likely develops in several phases, beginning with genetic risk, followed by asymptomatic autoimmunity, then finally, clinically apparent disease. Investigating the phases of disease that exist prior to the onset of symptoms (ie, the preclinical period of RA) will lead to understanding of the important relationships between genetic and environmental factors that may lead to disease, as well as allow for the development of predictive models for disease, and ultimately preventive strategies for RA.
Deane
Kevin D
KD
Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court, Mail Stop B-115, Aurora, CO 80045, USA. Kevin.Deane@UCDenver.edu <Kevin.Deane@UCDenver.edu>
Norris
Jill M
JM
Holers
V Michael
VM
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D010456:Peptides, Cyclic / Q000276:immunology; D012219:Rheumatology / Q000639:trends*; D012307:Risk Factors
D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide