Common variants in FOXP1 are associated with generalized vitiligo.
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).
Human Medical Genetics Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ying
Y
Jin
Stanca A
SA
Birlea
Pamela R
PR
Fain
Christina M
CM
Mailloux
Sheri L
SL
Riccardi
Katherine
K
Gowan
Paulene J
PJ
Holland
Dorothy C
DC
Bennett
Margaret R
MR
Wallace
Wayne T
WT
McCormack
E Helen
EH
Kemp
David J
DJ
Gawkrodger
Anthony P
AP
Weetman
Mauro
M
Picardo
Giovanni
G
Leone
Alain
A
Taïeb
Thomas
T
Jouary
Khaled
K
Ezzedine
Nanny
N
van Geel
Jo
J
Lambert
Andreas
A
Overbeck
Richard A
RA
Spritz
D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005192:Family Health; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins / Q000235:genetics*; D014820:Vitiligo / Q000235:genetics*
C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins