Reproducibility of high-sensitivity C-reactive protein as an inflammatory component of metabolic syndrome in Japanese.
BACKGROUND
Cutoff points for high-sensitivity C-reactive protein (hs-CRP) as a component of metabolic syndrome (MetS) in Japanese have been proposed as 0.40-0.45 mg/L for men and 0.25-0.35 mg/L for women. However, there are some concerns about the reproducibility of hs-CRP.


RESULTS
Reproducibility of hs-CRP as a component of MetS was examined using receiver-operating characteristic (ROC) curves for diagnosing MetS in 1,274 men and 673 women whose serum levels of hs-CRP were measured twice at annual health screening tests. The Spearman's correlation coefficient between baseline hs-CRP and hs-CRP at the next year's test was 0.68 in men and 0.71 in women. The area under the ROC curves of baseline hs-CRP, hs-CRP at the next year's test, and the mean of the 2 hs-CRP tests for diagnosing baseline MetS were 0.71, 0.71, and 0.72, respectively, in men and 0.75, 0.74, and 0.74, respectively, in women. Optimal cutoff points of baseline hs-CRP, hs-CRP at the next year's test, and the mean of 2 tests for diagnosing baseline MetS were all 0.40 mg/L in men and 0.35 mg/L in women.


CONCLUSIONS
The serum level of hs-CRP was stable enough for use as a measure of the inflammatory component of MetS, and the optimal cutoff point of hs-CRP was 0.40 mg/L for men and 0.35 mg/L for women in a Japanese health-screening population.
Oda
Eiji
E
Medical Check-up Center, Tachikawa Medical Center, Nagaoka, Japan. ijie@venus.sannet.ne.jp
Kawai
Ryu
R
D000328:Adult; D044466:Asian People; D002097:C-Reactive Protein / Q000032:analysis* / Q000592:standards; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D008297:Male; D008403:Mass Screening / Q000379:methods; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results
D002097:C-Reactive Protein