Angiotensin-converting enzyme insertion/deletion polymorphism associated with acute respiratory distress syndrome among caucasians.
Studies investigating the association between angiotensin-converting enzyme (ACE) insertion/deletion polymorphisms and the risk of acute respiratory distress syndrome (ARDS) report conflicting results. The objective of the present study was to summarize quantitatively the evidence for such a relationship. Two investigators independently searched the MEDLINE (January 1966 - October 2009) and EMBASE (January 1980 - October 2009) databases. This meta-analysis included six case-control studies, which included 514 ARDS cases and 2619 controls. The combined results based on all studies showed that patients with ARDS had a significantly higher frequency of the ACE deletion/deletion (DD) genotype (odds ratio [OR] 1.56; 95% confidence interval [CI] 1.22, 2.00) than controls. When stratifying for race, no significant differences in genotype distribution were found except that Caucasian patients with ARDS had a significantly higher frequency of the DD genotype (OR 1.65; 95% CI 1.27, 2.13) than controls. This meta-analysis suggests that ACE insertion/deletion polymorphisms may be associated with ARDS among Caucasians.
Hu
Z
Z
Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jin
X
X
Kang
Y
Y
Liu
C
C
Zhou
Y
Y
Wu
X
X
Liu
J
J
Zhong
M
M
Luo
C
C
Deng
L
L
Deng
Y
Y
Xie
X
X
Zhang
Z
Z
Zhou
Y
Y
Liao
X
X
D016022:Case-Control Studies; D006801:Humans; D015201:Meta-Analysis as Topic; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012128:Respiratory Distress Syndrome / Q000235:genetics*; D017384:Sequence Deletion; D044465:White People
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A