[A community-based study on relations between metabolic syndrome and carotid atherosclerosis in a middle-aged population].
OBJECTIVE
To explore the association between metabolic syndromes (MS) and carotid atherosclerosis and to estimate the predictive effects of MS under 3 different definitions.


METHODS
A cross-sectional study was conducted in 2 community-based populations in Beijing, in 2008. 1266 subjects (598 men, 668 women), aged 45 - 69, were included in the analyses. MS was defined by the criteria of International Diabetes Federation (IDF), the revised NCEP ATP III (ATPIII-R) and "The Guidelines of Dyslipidemia Control for Chinese Adult" ("Guidelines") in 2007.


RESULTS
The prevalence rates of MS by the 3 criteria were 39.0%, 43.3% and 30.9% respectively. The Kappa value for the measure of the agreement between each pair of the 3 definitions were 0.911, 0.719 and 0.730 respectively. The intima-media thickness in common carotid artery (CCA-IMT) was significantly higher (P < 0.001) in all MS groups than in non-MS groups, diagnosed with the 3 criteria independent of age, gender, LDL-C, and current smoking status. After adjustment of age, gender, LDL-C, and current smoking status, the classification of MS significantly increased the risk of prevalence of carotid atherosclerotic plaques, compared to the non-MS group. OR value were 1.499 (95%CI: 1.157 - 1.942) for IDF, 1.696 (95%CI: 1.314 - 2.189) for NCEP-R, 1.763 (95%CI: 1.344 - 2.312) for "Guideline" respectively.


CONCLUSIONS
Our research findings indicated that, when MS were defined with the 3 definitions, prediction on the risk of sub-clinical atherosclerosis would work beyond some of the conventional cardiovascular risk factors such as smoking, LDL-C. There might exist some differences in gender issue on the strength of association between MS when diagnosed by different criteria and carotid plaque.
Zou
Xiao-xuan
XX
Department of the Network for Prevention and Control, Cardiovascular Institute, Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.
Li
Ying
Y
Zhang
Hong-ju
HJ
Chen
Zuo
Z
Wang
Hao
H
Guo
Min
M
Wang
Qian-qian
QQ
Zhao
Lian-cheng
LC
Yang
Ying
Y
Zheng
Run-ping
RP
Cai
Yu-ling
YL
Gu
Dong-feng
DF
D000368:Aged; D002340:Carotid Artery Diseases / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors