Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation.
Cell proliferation and apoptosis in the remnant rat kidney after treatment with low-dose irradiation was investigated.


METHODS
In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9).


RESULTS
Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation.


CONCLUSIONS
The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.
Aunapuu
Marina
M
Department of Anatomy, University of Tartu, Estonia. marina.aunapuu@ut.ee
Arend
Andres
A
Ots
Mai
M
Pilmane
Mara
M
D000704:Analysis of Variance; D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D005455:Fluorescent Antibody Technique; D006973:Hypertension; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D007668:Kidney / Q000528:radiation effects*; D007677:Kidney Function Tests; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors