Escalation of glaucoma therapy after deep lamellar endothelial keratoplasty.
OBJECTIVE
To determine the prevalence and risk factors for escalation of glaucoma therapy after deep lamellar endothelial keratoplasty (DLEK).


METHODS
Retrospective review of every case of DLEK performed at a tertiary care facility between December 1, 2003 and January 31, 2006.


RESULTS
Eighty eyes met the inclusion criteria. Escalation of glaucoma therapy occurred in 13 eyes (16.3%) during a mean follow-up period of 27.1 months. Ten eyes required additional topical medical therapy, and 3 eyes required surgical intervention. Glaucoma therapy escalation was significantly associated with preexisting glaucoma (42.9% vs. 10.6%; P = 0.008).


CONCLUSIONS
Escalation of glaucoma therapy is not uncommon after DLEK, especially in eyes with preexisting glaucoma.
Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, USA.
George R
GR
Wandling
Mansi
M
Parikh
Christopher
C
Robinson
Sudeep N
SN
Pramanik
Kenneth M
KM
Goins
John E
JE
Sutphin
Wallace L M
WL
Alward
Emily C
EC
Greenlee
Young H
YH
Kwon
Michael D
MD
Wagoner
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage; D003316:Corneal Diseases / Q000150:complications / Q000601:surgery*; D057111:Descemet Stripping Endothelial Keratoplasty; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D020327:Glaucoma Drainage Implants; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014130:Trabeculectomy
D000959:Antihypertensive Agents