Species-specific CD1-restricted innate immunity for the development of HIV vaccine.
The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases; however, such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines.
Takahashi
Hidemi
H
Department of Microbiology and Immunology, Nippon Medical School, Tokyo 113-8602, 1-1-5 Sendagi, Bunkyo-ku, Japan. htkuhkai@nms.ac.jp
D016915:AIDS Vaccines / Q000276:immunology*; D017951:Antigen Presentation / Q000276:immunology; D018949:Antigens, CD1 / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D013045:Species Specificity
D016915:AIDS Vaccines; D018949:Antigens, CD1