Development of receptor bronchial system in isolated preparation of piglet trachea in vitro.
In this paper we present the flow research of the development of receptor bronchial system in the first month of extra-uterine life up to the sixth month of development, performed by tracking the reactions of isolated tracheal rings in acetylcholine (Ach), propranolol (P), histamine (Hist), and prostaglandin (PGF2-alfa) in concentrations of: 10-4, 10-3, 10-2 and 10-1 mol/dm3; in piglets of ages: 1 month, 2 months, 4 months and 6 months. Results shows that Ach causes reaction of smooth muscles from the first month of extra-uterine life (p < 0.01) and that Propranolol (P) significantly emphasizes the effect of Ach (p > 0.1), while histamine and PGF2-alpha do not cause constriction (histamine up to 4 months of age, PGF2-alfa up to 6 months of extra-uterine life). This shows that cholinergic and adrenergic system in piglet airways is developed during intrauterine life and reaction can be registered in the first month of extra-uterine life, while other receptor systems are developed in later periods of extra-uterine life. This suggests that lack of reaction of tracheal smooth musculature (TSM) comes as a result of sufficient non-maturity of mast cells from which chemical mediators, with local functioning, are released.
Department of Anatomy, Faculty of Medicine, University of Prishtina, Kosovo.
Sadi
S
Bexheti
Naim
N
Haliti
Hilmi
H
Islami
Aziz
A
Sukalo
Bajram
B
Nuraj
Valon
V
Krasniqi
Skender
S
Kutllovci
Rruke
R
Beqiraj
Mentor
M
Disha
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D014132:Trachea / Q000294:innervation / Q000502:physiology*
D006632:Histamine; D011433:Propranolol; D015237:Dinoprost; D000109:Acetylcholine