Life-threatening cardiac manifestations of primary antiphospholipid syndrome.
We report a rare case of primary antiphospholipid syndrome (APS) in a 43-year-old man presenting as recurrent acute coronary stent thrombosis and complicated by three myocardial infarctions. As illustrated in this report, in APS patients recurrent life-threatening arterial thrombotic events may occur in spite of recommended anticoagulant therapy. We conclude that the APS should be considered as a potential cause of acute coronary syndrome, particularly in young individuals with a history of recurrent thrombotic events and/or with abnormal coagulation test results. Further studies are needed to determine the best therapeutic strategy for APS patients with acute coronary syndrome.
Grzybczak
Rafal
R
Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, 80 Pradnicka Street, 31-202 Krakow, Poland. rafal_grzybczak@interia.pl
Undas
Anetta
A
Rostoff
Pawel
P
Gackowski
Andrzej
A
Czubek
Urszula
U
Stopyra
Katarzyna
K
Piwowarska
Wieslawa
W
D054058:Acute Coronary Syndrome / Q000097:blood / Q000209:etiology* / Q000628:therapy; D000328:Adult; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001777:Blood Coagulation; D023921:Coronary Stenosis / Q000097:blood / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D008670:Metals; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology / Q000628:therapy*; D011474:Prosthesis Design; D012008:Recurrence; D015607:Stents; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
D008670:Metals