Psychopathological and personality features in primary Sjogren's syndrome--associations with autoantibodies to neuropeptides.
OBJECTIVE
To determine the spectrum of personality and psychopathology features of patients with primary SS (pSS) and explore whether they are linked to disease characteristics as well as the presence of autoantibodies (autoAbs) against neuropeptides.


METHODS
Personality and psychopathological variables were determined in 103 pSS patients and 110 healthy controls (HCs). AutoAbs against hypothalamic and pituitary neuropeptides were measured by ELISA in 25 pSS patients and 25 HCs. Data analysis was performed by univariate and multivariate logistic regression models and by comparison with regression models.


RESULTS
A higher number of pSS patients reported distinct personality traits (neuroticism, psychoticism and obsessiveness) and psychological distress compared with HCs. After adjustment for personality characteristics and demographics, only hypochondriasis was the main psychopathology feature associated with pSS, suggesting that psychopathological manifestations in the setting of pSS are primarily dependent on premorbid personality characteristics. Although no differences were detected between serum levels of neuropeptide autoAbs in pSS cases and controls, levels of autoAbs against alpha-melanocyte-stimulating hormone (alpha-MSH) correlated with anxiety scores in both groups examined but with higher intercept in pSS subjects. Significant correlations between anxiety score and autoAbs directed against oxytocin and vasopressin were also detected in the pSS patients.


CONCLUSIONS
pSS patients exhibit a distinct pattern of personality traits and high levels of psychological distress compared with HCs, which seems to be determined by premorbid personality characteristics. Correlations between anxiety and alpha-MSH autoAbs suggest their potential involvement in anxiety development in both pSS and HCs.
Karaiskos
Dimitrios
D
Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
Mavragani
Clio P
CP
Sinno
Maria Hamze
MH
Déchelotte
Pierre
P
Zintzaras
Elias
E
Skopouli
Fotini N
FN
Fetissov
Sergueï O
SO
Moutsopoulos
Haralampos M
HM
D000368:Aged; D001008:Anxiety Disorders / Q000209:etiology / Q000523:psychology*; D001323:Autoantibodies / Q000276:immunology*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000276:immunology*; D010551:Personality; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology* / Q000523:psychology; D000521:alpha-MSH / Q000276:immunology
D001323:Autoantibodies; D009479:Neuropeptides; D000521:alpha-MSH