Immunoglobulin G4 related systemic sclerosing disease involving the temporal bone.
OBJECTIVE
To report a rare condition affecting the temporal bone. Immunoglobulin G4 related systemic sclerosing disease is a recently described autoimmune condition with manifestations typically involving the pancreas, biliary system, salivary glands, lungs, kidneys and prostate. Histologically, it is characterised by T-cell infiltration, fibrosis and numerous immunoglobulin G4-positive plasma cells. This condition previously fell under the umbrella diagnosis of inflammatory pseudotumour and inflammatory myofibroblastic tumour.


METHODS
We present the case of a 58-year-old woman with multiple inflammatory masses involving the pharynx, gall bladder, lungs, pelvis, omentum, eyes and left temporal bone, over a seven-year period. We describe this patient's unusual clinical course and pathological features, which resulted in a change of diagnosis from metastatic inflammatory myofibroblastic tumour to immunoglobulin G4 related systemic sclerosing disease. We also review the literature regarding the management of inflammatory pseudotumours of the temporal bone, and how this differs from the management of immunoglobulin G4 related systemic sclerosing disease.


CONCLUSIONS
We would recommend a full review of all histological specimens in patients with a diagnosis of temporal bone inflammatory pseudotumour or inflammatory myofibroblastic tumour. Consideration should be given to immunohistochemical analysis for anaplastic lymphoma kinase and immunoglobulin G4, with measurement of serum levels of the latter. Management of the condition is medical, with corticosteroids and immunosuppression, rather than surgical excision.
Department of Otolaryngology, Norfolk and Norwich University Hospital, UK.
L
L
Masterson
M Martinez
MM
Del Pero
N
N
Donnelly
D A
DA
Moffat
E
E
Rytina
D001706:Biopsy; D003937:Diagnosis, Differential; D004427:Ear Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D011859:Radiography; D012595:Scleroderma, Systemic / Q000276:immunology / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology*
D007074:Immunoglobulin G