Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve.
Maximal receiver operating characteristic curve inflections, which differentiate between better and poorer delivery chances in women with diminished ovarian reserve (DOR) independent of age, were at anti-Müllerian hormone (AMH) 1.05 ng/mL (improved odds for live birth 4.6 [2.3-9.1), 95% confidence interval; Wald 18.8, df = 1], although live births occurred even with undetectable AMH. Pregnancy wastage was very low at AMH ≤0.04 ng/mL but significantly increased at AMH 0.41-1.05 ng/mL, resulting in similarly low live-birth rates at all AMH levels ≤1.05 ng/mL and significantly improved live-birth rates at AMH ≥1.06 ng/mL.
The Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York 10021, USA. ngleicher@thechr.com
Norbert
N
Gleicher
Andrea
A
Weghofer
David H
DH
Barad
D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000097:blood* / Q000502:physiology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002452:Cell Count; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D050498:Live Birth / Q000453:epidemiology; D008875:Middle Aged; D009865:Oocytes / Q000473:pathology; D010053:Ovary / Q000473:pathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012372:ROC Curve; D012680:Sensitivity and Specificity
D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone