Terpenoids from Salvia trijuga.
Nine new germacrane sesquiterpenes, trijugins A-I (1-9), a new lupane triterpenoid, 3alpha-O-acetyl-20(29)-lupen-2alpha-ol (10), and 24 known terpenoids were isolated from Salvia trijuga. The structure of compound 1 was confirmed by single-crystal X-ray diffraction. Compounds 1-10 and 32 were evaluated for their cytotoxicity against five human tumor cell lines. Compounds 9 and 32 exhibited moderate toxicity effects against several cell lines.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People's Republic of China.
Zheng-Hong
ZH
Pan
Yuan-Yuan
YY
Wang
Ming-Ming
MM
Li
Gang
G
Xu
Li-Yan
LY
Peng
Juan
J
He
Yu
Y
Zhao
Yan
Y
Li
Qin-Shi
QS
Zhao
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027544:Salvia / Q000737:chemistry*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D045788:Sesquiterpenes, Germacrane; D014315:Triterpenes