[Association of single nucleotide polymorphisms of kallikrein 1 gene with cerebral hemorrhage in Changsha Han Chinese].
OBJECTIVE
To explore the association between single nucleotide polymorphisms (SNPs) of KLK1 gene and cerebral hemorrhage in Changsha Han Chinese.


METHODS
Two hundred and seventy-three cerebral hemorrhage (CH) patients and 140 healthy controls were collected. The SNPs of rs5516 and rs5517 loci of KLK1 gene were analyzed by SNaPshot methods and direct sequencing.


RESULTS
(1)Genotype and allele frequencies in rs5516 locus had no difference between the CH patients and controls (P> 0.05). However, the A allele frequency of the rs5517 locus in CH patients was higher than that in the control group (0.419, 0.321 respectively, P< 0.05). (2)In the control group,the levels of diastolic blood pressure (DBP) of the GA and AA genotype carriers of the rs5517 locus were significantly higher than those of the GG genotype (P< 0.05), while the levels of blood pressure were not significantly different among different genotypes of the rs5516 polymorphism in both CH patients and the control group(P> 0.05).


CONCLUSIONS
Author's preliminary results suggested that the rs5517 polymorphism was associated with cerebral hemorrhage, while the rs5516 polymorphism was not in Changsha Han Chinese.
Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011 PR China.
Yi
Y
Zeng
Le
L
Zhang
Zhong-yang
ZY
Hu
Qi-dong
QD
Yang
Bao-qiong
BQ
Liu
Ming-ming
MM
Ma
Yun-hai
YH
Liu
Hong-wei
HW
Xu
Jian
J
Xia
Xiao-ping
XP
Du
Zhi-ping
ZP
Hu
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002543:Cerebral Hemorrhage / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020840:Tissue Kallikreins / Q000235:genetics*
D020840:Tissue Kallikreins