IgG₄-related sclerosing disease: a novel mimic of inflammatory bowel disease.
High levels of IgG₄-positive plasma cells are commonly seen in autoimmune pancreatitis. It has recently become evident that autoimmune pancreatitis is one component of a larger multi-system disease. IgG₄-positive plasma cells have been identified in many extrapancreatic tissues, including the colon, biliary tract, liver, and lungs, and thus the term "IgG₄-related sclerosing disease" has been proposed. Awareness of IgG₄-related sclerosing disease is important, as it has been shown to mimic other conditions like malignancy. This review discusses IgG₄-related colitis and its potential for mimicking inflammatory bowel disease.
Narula
Neeraj
N
Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.
Vasudev
Monica
M
Marshall
John K
JK
D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000276:immunology*; D003424:Crohn Disease / Q000453:epidemiology / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D010195:Pancreatitis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000453:epidemiology; D010950:Plasma Cells / Q000276:immunology; D015995:Prevalence; D012598:Sclerosis
D007074:Immunoglobulin G