Beta-conglycinin lowers very-low-density lipoprotein-triglyceride levels by increasing adiponectin and insulin sensitivity in rats.
The relationship between insulin sensitivity and the plasma triglyceride-lowering effect induced by beta-conglycinin was investigated. Male Wistar rats (19 weeks old) were fed diets containing casein, soy protein isolate, or beta-conglycinin for 4 weeks. In oral glucose administration, the beta-conglycinin-fed rats showed a significant decrease in the area under the glucose curve (0-60 min) as compared with the casein-fed rats. The hypoglycemic effect was significantly higher in the beta-conglycinin-fed rats than in the casein-fed rats at 30 min after intraperitoneal insulin injection. The liver sterol regulatory element-binding-protein-1 mRNA expression level was significantly lower and the plasma adiponectin concentration was significantly higher in the beta-conglycinin-fed rats than in the casein-fed rats. The hypotriglyceridemic effect of beta-conglycinin depended on a significant decrease in the concentration of very-low-density-lipoprotein triglycerides. These results indicate that beta-conglycinin increases adiponectin levels and improves glucose tolerance. The ability of beta-conglycinin to lower plasma lipid levels might be due to increased insulin sensitivity of the liver.
Tachibana
Nobuhiko
N
Food Science Institute, Fuji Oil Co., Ltd., Izumisano, Japan. tachibana.nobuhiko@so.fujioil.co.jp
Iwaoka
Yasue
Y
Hirotsuka
Motohiko
M
Horio
Fumihiko
F
Kohno
Mitsutaka
M
D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D052179:Antigens, Plant / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D005916:Globulins / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D055314:Seed Storage Proteins / Q000494:pharmacology*; D030262:Soybean Proteins / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
D052242:Adiponectin; D052179:Antigens, Plant; D005916:Globulins; D007328:Insulin; D008077:Lipoproteins, LDL; D012333:RNA, Messenger; D055314:Seed Storage Proteins; D030262:Soybean Proteins; D014280:Triglycerides; C013894:beta-conglycinin protein, Glycine max