Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.
The synthesis and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated, and some of these derivatives showed better in vitro antibacterial activity than existing drugs, including penicillin, ciprofloxacin, vancomycin, and linezolid.
Department of Chemistry, East China Normal University, Shanghai, China.
Wei
W
Shi
Yuejiao
Y
Duan
Yu
Y
Qian
Ming
M
Li
Liping
L
Yang
Wenhao
W
Hu
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D015195:Drug Design; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000588:Amines; D000900:Anti-Bacterial Agents; D011758:Pyrroles; D000581:Amidohydrolases; C084507:peptide deformylase