Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis.
A 60-year-old woman, presented with hirsutism, male pattern baldness, deepening voice and plethora over the past 5 years. Hormonal evaluation showed markedly elevated serum testosterone level (> 1600 ng/dl) and oestradiol level (220 pg/ml) normal DHEA-SO4 level with suppressed LH and FSH levels. She had markedly erythrocytosis with normal hematological indices. The diagnosis of probable secondary erythrocytosis was made. Trans abdominal ultrasound and CT scan revealed a 14 cm × 11 cm × 9 cm solid pelvic mass. An ovarian androgen secreting tumour was suspected and surgery was performed. Histological examination showed a leydig cell tumour. After the operation testosterone and haematocrit levels returned to normal with regression of clinical symptoms. This is the first case of a leydig cell tumour with an erythropoietic effect of excess testosterone.
Cerrahpasa Medical Faculty, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Istanbul, Turkey. demetozgil@yahoo.com
Demet Ozgil
DO
Yetkin
Esra Terzi
ET
Demirsoy
Pinar
P
Kadioglu
D005260:Female; D006628:Hirsutism / Q000209:etiology*; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology*; D007984:Leydig Cell Tumor / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D010053:Ovary / Q000473:pathology; D011086:Polycythemia / Q000209:etiology*; D017698:Postmenopause