Ultrasound-assisted one-pot, four component synthesis of 4-aryl 3,4-dihydropyridone derivatives.
The condensation of Meldrum's acid, aromatic aldehydes, alkyl acetoacetates and ammonium acetate in glacial acetic acid under ultrasound irradiation at room temperature results in the formation of 3,4-dihydropyridone derivatives (4a-p) in 85-96% yields. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction times and higher yields.
Ruiz
Enrique
E
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400-Ciudad Habana, Cuba.
Rodríguez
Hortensia
H
Coro
Julieta
J
Salfrán
Esperanza
E
Suárez
Margarita
M
Martínez-Alvarez
Roberto
R
Martín
Nazario
N
D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014465:Ultrasonics
D011728:Pyridones