Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation.
The cell wall of Saccharomyces cerevisiae can bind mycotoxins in vitro, but there is scarce information on whether this property decreases the absorption of mycotoxins in vivo. The effect of a yeast cell wall preparation (YCW) on toxicokinetics and balance excretion (urine and faeces) of aflatoxin B(1) (AFB1) and ochratoxin A (OTA) was tested in rats after oral administration of each toxin. The (3)H-labelled mycotoxins were used at low doses. Co-administration of YCW with AFB1 decreased the extent, but not the rate, of absorption. Concurrently, radioactivity excreted in faeces increased by up to 55% when compared with controls, whilst the excretion in urine decreased (p < 0.05). The effect of YCW on OTA was less marked, although it increased radioactivity excretion in faeces (up to 16%; p < 0.05) it did not result in changes in urine and toxicokinetic parameters. The in vivo effect is in agreement with the reported in vitro binding ability for these toxins (AFB1 > OTA). In conclusion, these results indicate that YCW could be used to protect monogastric animals against exposure to low dietary levels of selected mycotoxins.
Firmin
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INRA, UR1213 Herbivores, Site de Theix, F-63122 Saint Genès-Champanelle, France.
Gandia
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P
Morgavi
D P
DP
Houin
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G
Jouany
J P
JP
Bertin
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G
Boudra
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H
D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D002457:Cell Extracts / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005243:Feces / Q000737:chemistry; D005506:Food Contamination; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009793:Ochratoxins / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D010949:Plasma / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D014556:Urine / Q000737:chemistry
D002457:Cell Extracts; D009793:Ochratoxins; D020011:Protective Agents; C025589:ochratoxin A; D016604:Aflatoxin B1