Fetal dopamine receptor characteristics assessed in utero.
Any tracer in fetal tissue comes from maternal arterial blood. Provided steady state is achieved and intermediate compartments are reversible, the Logan graphical methods should be applicable to the assessment of binding parameters in the fetal brain. Two pregnant rhesus macaques were studied with fallypride and the Logan method was used to assess dopamine receptor distribution volume ratios (DVRs) in both maternal and fetal striatum. The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met.
Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Rachel M
RM
Bartlett
Onofre T
OT
Dejesus
Todd E
TE
Barnhart
R Jerome
RJ
Nickles
Bradley T
BT
Christian
John L
JL
Graner
James E
JE
Holden
D000818:Animals; D001549:Benzamides; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000000981:diagnostic imaging / Q000378:metabolism*; D008253:Macaca mulatta; D049268:Positron-Emission Tomography / Q000379:methods*; D011247:Pregnancy; D011759:Pyrrolidines; D011954:Receptors, Dopamine / Q000097:blood / Q000378:metabolism*
D001549:Benzamides; C094948:N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; D011759:Pyrrolidines; D011954:Receptors, Dopamine