Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
OBJECTIVE
The assessment of the clinical significance of creatine, cytosine, cytidine, uridine, thymine, thymidine, and 2'-deoxyuridine concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between pyrimidine metabolites and disease.


METHODS
The study group consisted of 119 subjects, which were divided to three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23), and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants.


RESULTS
There is a significant increase in levels of cytosine (P<0.001), cytidine (P<0.001), and thymidine (P=0.016) with DN compared to DM. The levels of uridine, thymine, 2'-deoxyuridine, and creatine did not change.


CONCLUSIONS
The levels of cytosine, cytidine, and thymidine may be useful for monitoring the progression of DM and evaluating the treatment.
Xia
Jian-Fei
JF
School of Pharmaceutics, East-China University of Science and Technology, Shanghai, PR China.
Hu
Ping
P
Liang
Qiong-Lin
QL
Zou
Ting-Ting
TT
Wang
Yi-Ming
YM
Luo
Guo-An
GA
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003401:Creatine / Q000097:blood*; D003562:Cytidine / Q000097:blood; D003596:Cytosine / Q000097:blood; D003857:Deoxyuridine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000097:blood*; D053719:Tandem Mass Spectrometry; D013936:Thymidine / Q000097:blood; D013941:Thymine / Q000097:blood; D014529:Uridine / Q000097:blood
D011743:Pyrimidines; D003562:Cytidine; D003596:Cytosine; C030986:pyrimidine; D003401:Creatine; D013941:Thymine; D013936:Thymidine; D003857:Deoxyuridine; D014529:Uridine