Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2-nitropropane-induced hepatotoxicity in rats.
Organoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress. Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)(2); 50 mg kg(-1), p.o.) against the 2-nitropropane (2-NP)-induced hepatoxicity in rats, using different end points of toxicity (liver histopathology, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine). In addition, in view of the association of oxidative stress with 2-NP exposure, hepatic lipid peroxidation, ascorbic acid levels, delta-aminolevulinate dehydratase (delta-ALA-D) and catalase (CAT) activities were evaluated. 2-NP caused an increase of AST, ALT and hepatic lipid peroxidation. 2-NP also caused hepatic histopathological alterations and delta-ALA-D inhibition. (NapSe)(2) (50 mg kg(-1)) prevented 2-NP-induced changes in plasmatic ALT and AST activities and also prevented changes in hepatic histology, delta-ALA-D and lipid peroxidation. Results presented here indicate that the protective mechanism of (NapSe)(2) against 2-NP hepatotoxicity is possibly linked to its antioxidant activity.
Ibrahim
Mohammad
M
Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Prigol
Marina
M
Hassan
Waseem
W
Nogueira
Cristina W
CW
Rocha
Joao B T
JB
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D003404:Creatinine / Q000378:metabolism; D015227:Lipid Peroxidation; D009595:Nitroparaffins / Q000633:toxicity; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011407:Propane / Q000031:analogs & derivatives / Q000633:toxicity; D051381:Rats
D000975:Antioxidants; D009595:Nitroparaffins; D016566:Organoselenium Compounds; C551844:binaphthyl diselenide; D003404:Creatinine; D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000623:Porphobilinogen Synthase; C016617:2-nitropropane; D001205:Ascorbic Acid; D011407:Propane