Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives.
In search for a new analgesic and anti-inflammatory agent with improved potency, we designed and synthesized a series of 3,2-(4,5-dihydro-5-(4-morphilinophenyl)-1H-pyarazol-3-yl)phenols 6(a-g) and its N-phenylpyrazol-1-carbothioamide 7(a-g) by Claisan-Schmidt condensation followed by the reaction of hydrazine hydrate. All the synthesized compounds were assayed for their in vivo analgesic and anti-inflammatory activities. All the compounds synthesized showed the potential to demonstrate analgesic and anti-inflammatory activity, of particular interest compounds 6a, 6b, 6g, 7a, 7d and 7g were found comparable to Diclofenac.
Joshi
Ratnadeep S
RS
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India.
Mandhane
Priyanka G
PG
Diwakar
Santosh D
SD
Dabhade
Sanjay K
SK
Gill
Charansingh H
CH
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004008:Diclofenac; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006834:Hydrazines; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D006834:Hydrazines; D011720:Pyrazoles; D004008:Diclofenac; C029424:hydrazine