Localization and histological characterization of injected hyaluronic acid in excised nasolabial fold tissue.
OBJECTIVE
To describe a technique for surgical correction of a prominent nasolabial fold (NLF) and use of the excised fold to assess the histology and localization of injected hyaluronic acid (HA) fillers.


METHODS
Surgical correction was achieved by direct excision of the NLF, followed by advancement of the nasolabial fat compartment into the nasolabial crease. Excised tissue samples were injected with HA fillers (Restylane, Perlane, or layered Restylane/ Perlane), sectioned, and treated with histological stains.


RESULTS
Surgical correction of NLF resulted in highly satisfactory results. HA localized primarily in the lower reticular dermis and subcutis of the excised NLF. Localization appeared similar regardless of the HA product employed.


CONCLUSIONS
Direct excision of the NLF with advancement of the nasolabial fat compartment is a successful treatment for patients with deep NLF. HA injected into the excised tissue localized near the site of injection, emphasizing the importance of proper placement of HA fillers during soft tissue augmentation.
Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. timg@drgrecoface.com
Timothy M
TM
Greco
Rosalie
R
Elenitsas
D003357:Cosmetic Techniques; D005145:Face; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007267:Injections; D008297:Male; D008875:Middle Aged; D012060:Rejuvenation; D015595:Skin Aging
D006820:Hyaluronic Acid