[Role and place of albumin dialysis in the treatment of patients with hepatic insufficiency].
The term "hepatic insufficiency" (HI) unites various hepatic dysfunctions that may be further completely compensated and that may progress until coma develops. Comprehensive examination and treatment were performed in 96 patients (64 males and 32 females) with HI. Irrespective of an etiological factor and a HI form, all the patients were divided into three groups. All the three groups received drug therapy; plasmapheresis was additionally carried out in Group 2 while in Group 3 hepatic function was maintained by therapy involving the combination removal of both albumin-bound (hydrophobic) and water-soluble toxins via the mechanism of transportation of these substances across the membrane without eliminating the substances that are important and useful for the body (MARS). The findings have indicated that combination treatment using MARS makes it possible to restore hepatic synthetic function, to alleviate the signs of cytolysis and cholestasis, and to reduce the degree of encephalopathy. In addition, MARS provides hemodynamic stabilization that allows the inotropic support to be lowered.
Kutepov
D E
DE
Pasechnik
I N
IN
Popov
A V
AV
Kontarev
S I
SI
Krylov
V V
VV
D000418:Albumins / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D015314:Dialysis Solutions; D005260:Female; D048550:Hepatic Insufficiency / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D010956:Plasmapheresis; D006435:Renal Dialysis / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000418:Albumins; D015314:Dialysis Solutions