One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones.
A new concise, facile, and efficient method for the synthesis of 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridine derivatives has been described. The cyclocondensation of isoflavones with 3-amino-5-hydroxypyrazole in the presence of sodium methoxide gave fused heteroaromatic 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridines in moderate to good yields.
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, PR China. zhangzt@snnu.edu.cn
Zun-Ting
ZT
Zhang
Yong
Y
Liang
Yu-Qing
YQ
Ma
Dong
D
Xue
Jun-Ling
JL
Yang
D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D007529:Isoflavones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D007529:Isoflavones; D011720:Pyrazoles; D011725:Pyridines; D054852:Small Molecule Libraries; C447480:pyrazolo(3,4-b)pyridine