Bilateral Lhermitte-Duclos disease.
Lhermitte-Duclos disease (LDD) is a pathologic entity with progrediating, diffuse hypertrophy chiefly of the stratum granulosum of the cerebellum. Typically LDD is a unilateral lesion of the cerebellum or in vermis. Here we report a case of LDD with bilateral lesions of cerebellar hemispheres managed surgically. A 28-year-old woman presented with one-year history of progressive headache, nausea, vomiting, and blurred vision. Neurologic examination revealed a bilateral mild papilledema, mild dysmetria, and dysdiadochokinesia. The cerebellar lesions caused moderate mass effect in posterior fossa with hydrocephalus, and Chiari type I malformation. We performed the suboccipital-retrosigmoid approach, and removed completely the left intracerebellar mass. Symptoms related to elevated intracranial pressure disappeared in a short period postoperatively.
Bozbuga
Mustafa
M
2nd Department of Neurosurgery, Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.
Gulec
Ilker
I
Suslu
Hikmet Turan
HT
Bayindir
Cicek
C
D000328:Adult; D002531:Cerebellum / Q000473:pathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006223:Hamartoma Syndrome, Multiple / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009460:Neurologic Examination / Q000379:methods; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D016708:Synaptophysin / Q000378:metabolism
D016708:Synaptophysin