Meal fat storage in subcutaneous adipose tissue: comparison of pioglitazone and glipizide treatment of type 2 diabetes.
Treatment of type 2 diabetes (T2DM) with pioglitazone changes abdominal fat in the opposite direction as treatment with glipizide. To determine whether these two medications affect adipose tissue meal fatty acid storage differently we studied 19 T2DM treated with either pioglitazone (n = 8) or glipizide (n = 11) and 11 non-DM control subjects matched for age, BMI, abdominal and leg fat. A breakfast mixed meal containing [1-(14)C]triolein was given and abdominal and femoral subcutaneous (sc) adipose tissue biopsies were collected 6 and 24 h later to measure meal fatty acid storage. The portion of meal fatty acids stored in upper body sc and lower body sc adipose tissue did not differ between non-DM and T2DM subjects either at 6 or 24 h. Likewise, meal fatty acid storage did not differ between the T2DM participants treated with pioglitazone or glipizide. We conclude that meal fatty acid storage in upper body and lower body sc adipose tissue is not abnormal in T2DM patients treated with pioglitazone or glipizide.
Basu
Ananda
A
Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. basu.ananda@mayo.edu
Basu
Rita
R
Pattan
Vishwanath
V
Rizza
Robert A
RA
Jensen
Michael D
MD
D001706:Biopsy; D002247:Carbon Isotopes / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D005260:Female; D005913:Glipizide / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000077205:Pioglitazone; D050151:Subcutaneous Fat / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology* / Q000627:therapeutic use; D014304:Triolein / Q000378:metabolism
D002247:Carbon Isotopes; D004041:Dietary Fats; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D014304:Triolein; D000077205:Pioglitazone; D005913:Glipizide