Hormonal influences on cognition and risk for Alzheimer's disease.
Research increasingly suggests that changes in estrogen levels during aging may increase the risk of Alzheimer's disease, the most common type of dementia. This update reviews the newest information about estrogen and cognitive aging, including information regarding the role of bioavailable estrogen in older women and men, use of selective estrogen receptor modulators to improve cognition, and studies of genetic risk factors to elucidate the effects of endogenous estrogen on aging and cognition. Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia.
Janicki
Sarah C
SC
G. H. Sergievsky Center, Columbia University Medical Center, 622 West 168th Street, PH-19, New York, NY 10019, USA. scj2110@columbia.edu
Schupf
Nicole
N
D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000150:complications / Q000209:etiology / Q000378:metabolism; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology* / Q000517:prevention & control; D004967:Estrogens / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use; D012307:Risk Factors; D012727:Sex Characteristics
D004967:Estrogens; D018696:Neuroprotective Agents