Characterization of pseudacyclins A-E, a suite of cyclic peptides produced by Pseudallescheria boydii.
Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species.
Pavlaskova
Katerina
K
Institute of Microbiology, Videnska 1083, 142 20 Prague 4, Czech Republic.
Nedved
Jan
J
Kuzma
Marek
M
Zabka
Martin
M
Sulc
Miroslav
M
Sklenar
Jan
J
Novak
Petr
P
Benada
Oldrich
O
Kofronova
Olga
O
Hajduch
Marian
M
Derrick
Peter J
PJ
Lemr
Karel
K
Jegorov
Alexandr
A
Havlicek
Vladimir
V
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D011541:Pseudallescheria / Q000737:chemistry* / Q000472:pathogenicity
D010456:Peptides, Cyclic