Effects of experimental Unemployment, Employment and Punishment analogs on opioid seeking and consumption in heroin-dependent volunteers.
This study investigated the extent to which hydromorphone (HYD) choice and behavioral economic demand differed during experimental analogs of Unemployment (Drug Only: HYD and no money alternative), Employment (Drug or Money: HYD and $4 alternative), and Punishment (Drug Only+Money Loss: HYD only and $4 subtracted for each HYD choice), in the context of anticipated high vs. low post-session drug availability (HYD 24 mg vs. placebo). Eleven heroin-dependent, buprenorphine-stabilized (8 mg/day) volunteers first sampled two HYD doses (0 and 24 mg IM in randomized, counterbalanced order, labeled Drug A [session 1] and Drug B [session 2]). In each of the final six sessions, volunteers were given access to a 12-trial choice progressive ratio (PR) task and could work to receive HYD unit doses (2mg each); cumulative dose units earned were administered in a bolus injection after the work session. Before the PR task, volunteers were told which HYD dose (Drug A or B) would be available 3h after the PR-contingent injection. Relative to Unemployment (Drug Only), Employment (Drug or Money) and Punishment (Drug Only+Money Loss) each significantly suppressed HYD seeking (e.g., breakpoints). Employment and Punishment also reduced HYD behavioral economic demand, but via different mechanisms: Employment increased HYD price-elasticity, whereas Punishment decreased HYD demand intensity. Adjusting for the initial level difference (i.e., normalized demand), Employment significantly decreased P(max) (i.e., lower "essential value" of HYD) and O(max) (maximum HYD responding) compared to Punishment or Unemployment. These effects were not significantly altered by post-session drug availability.
Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA. mgreen@med.wayne.edu
Mark K
MK
Greenwald
D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology; D000704:Analysis of Variance; D002047:Buprenorphine / Q000627:therapeutic use; D002755:Choice Behavior; D004311:Double-Blind Method; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D004651:Employment / Q000523:psychology*; D005260:Female; D005717:Games, Experimental; D006556:Heroin Dependence / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D004091:Hydromorphone / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009294:Narcotics / Q000627:therapeutic use; D011678:Punishment / Q000523:psychology*; D012054:Reinforcement, Psychology
D000701:Analgesics, Opioid; D009294:Narcotics; D002047:Buprenorphine; D004091:Hydromorphone