[The importance of laboratory diagnosis in allo-immunization through pregnancy and hemolytic disease of the newborn].
BHNN is an affection in which life duration of fetus red cells is decreased by means of maternal antibodies opposing certain antigens inherited from the father.The present study will prove the importance of laboratory tests in the diagnosis of alloimmunization through pregnancy and BHNN.


METHODS
Laboratory determinations were performed between March 2008 and February 2009 on samples from 187 Rh negative pregnant female with incompatible pregnancy and Rh D positive newborns; there was used a certain algorithm for and identifying.


RESULTS
After applying the proposed algorithm, 4.2% of the cases were discovered to be immunized, whereas 2.6% of the cases were BHNN. As the specificity of irregular antibodies involved, 62.5% were anti D, 25% anti Kell and 12.5% anti E. The results show the fact that the incidence of these pathological entities is far more extended than in other countries.


CONCLUSIONS
Owing to the fact that alloimmunization by pregnancy and BHNN is still a frequent phenomenon, an attentive supervision is very important both for preparing the patient and the medical team aiming to prevent perinatal morbidity.
Centrul Regional de Transfuzie Sanguină Târgu-Mureş.
Dana Paula
DP
Florea
D015415:Biomarkers / Q000097:blood; D004899:Erythroblastosis, Fetal / Q000517:prevention & control; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood; D011181:Postnatal Care; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology; D011295:Prenatal Care; D015995:Prevalence; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D012204:Rh-Hr Blood-Group System / Q000097:blood; D018029:Rho(D) Immune Globulin; D012383:Romania / Q000453:epidemiology; D012494:Sampling Studies
D015415:Biomarkers; D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin