HIV-2 capsids distinguish high and low virus load patients in a West African community cohort.
HIV-2 causes AIDS similar to HIV-1, however a considerable proportion of HIV-2 infected patients show no disease and have low plasma virus load (VL). An analysis of HIV-2 capsid (p26) variation demonstrated that proline at p26 positions 119, 159 and 178 are more frequent in lower VL subjects while non-proline residues at all three sites are more frequent in subjects with high VL. In vitro replication levels of viruses bearing changes at the three sites suggested that these three residues influence virus replication by altering susceptibility to TRIM5alpha. These results provide new insights into HIV-2 pathogenesis.
Onyango
Clayton O
CO
Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia. conyango@mrc.gm
Leligdowicz
Aleksandra
A
Yokoyama
Masaru
M
Sato
Hironori
H
Song
Haihan
H
Nakayama
Emi E
EE
Shioda
Tatsuo
T
de Silva
Thushan
T
Townend
John
J
Jaye
Assan
A
Whittle
Hilton
H
Rowland-Jones
Sarah
S
Cotten
Matthew
M
D000090103:Antiviral Restriction Factors; D002213:Capsid / Q000821:virology*; D002352:Carrier Proteins / Q000378:metabolism; D015331:Cohort Studies; D006169:Guinea-Bissau; D015658:HIV Infections / Q000821:virology*; D015498:HIV-2 / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000235:genetics; D020539:Sequence Analysis, Protein; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D019562:Viral Load; D014779:Virus Replication; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism
D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D012367:RNA, Viral; D000070584:Tripartite Motif Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C065558:gag protein p26, Human immunodeficiency virus; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases