Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review.
This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity. Inflammatory adipokines [IL-6, IL-10, ACE, TGFbeta1, TNFalpha, IL-1beta, PAI-1, and IL-8] plus one anti-inflammatory [IL-10] adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue. In contrast, the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue. The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed. The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA. jfain@uthsc.edu
John N
JN
Fain
D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D009852:Omentum / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism / Q000502:physiology; D051197:Toll-Like Receptor 4 / Q000378:metabolism
D054392:Adipokines; D018836:Inflammation Mediators; D012333:RNA, Messenger; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4