Epigenetic control of aging.
Organismal aging and longevity are influenced by many complex interacting factors. Epigenetics has recently emerged as another possible determinant of aging. Here, we review some of the epigenetic pathways that contribute to cellular senescence and age-associated phenotypes. Strategies aimed to reverse age-linked epigenetic alterations may lead to the development of new therapeutic interventions to delay or alleviate some of the most debilitating age-associated diseases.
Muñoz-Najar
Ursula
U
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA. ursula_munoz-najar@brown.edu
Sedivy
John M
JM
D000375:Aging / Q000235:genetics*; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D008954:Models, Biological; D010641:Phenotype