Master regulator or readout: the wisdom of distributed control. Focus on "Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes".
Brooks
George A
GA
Department of Integrative Biology, University of California, Berkeley, California 94720-3140, USA. gbrooks@berkeley.edu
D000818:Animals; D002460:Cell Line; D004579:Electron Transport / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D019289:Pyruvic Acid / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D013379:Substrate Specificity / Q000502:physiology; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C501429:Ppargc1a protein, rat; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D019289:Pyruvic Acid