Effect of nanoparticle surface charge at the plasma membrane and beyond.
Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.
Arvizo
Rochelle R
RR
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Miranda
Oscar R
OR
Thompson
Michael A
MA
Pabelick
Christina M
CM
Bhattacharya
Resham
R
Robertson
J David
JD
Rotello
Vincent M
VM
Prakash
Y S
YS
Mukherjee
Priyabrata
P
D017209:Apoptosis; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism*; D049109:Cell Proliferation; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008564:Membrane Potentials; D053768:Metal Nanoparticles / Q000737:chemistry*; D055672:Static Electricity
D006046:Gold; D002118:Calcium