Smart biomaterials - regulating cell behavior through signaling molecules.
Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior. Following the recent work of Mitchell and co-workers published in BMC Biology, we review how spatial and temporal control of signaling molecules in a matrix material regulates cellular responses for tissue-specific applications.
Mieszawska
Aneta J
AJ
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. aneta.mieszawska@tufts.edu
Kaplan
David L
DL
D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology*; D053605:Leukemia Inhibitory Factor / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D053495:Osteopontin / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends
D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D053605:Leukemia Inhibitory Factor; D053495:Osteopontin; D020932:Nerve Growth Factor