Total synthesis of decarestrictine I and botryolide B via RCM protocol.
A convergent stereoselective total synthesis of decarestrictine I (1) and botryolide B (1a) invoking a common synthetic strategy is reported. The key steps are: ring-closing metathesis of epoxy dienoic esters obtained through the Yamaguchi esterification of their respective intermediates to furnish the respective Z-macrocycles (2 and 2a) which were further extrapolated to their respective targets.
Radha Krishna
Palakodety
P
D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 607, India. prkgenius@iict.res.in
Rao
T Jagannadha
TJ
D004852:Epoxy Compounds / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D004852:Epoxy Compounds; D007783:Lactones; C552596:botryolide B; C552595:decarestrictine I