Antimicrobial activity of the dichloromethane extract from in vitro cultured roots of Morinda royoc and its main constituents.
The dichloromethane extract and seven anthraquinones isolated from in vitro cultured roots of Morinda royoc L. were tested for their antimicrobial activity against seven yeast and seven bacterial strains. The extract showed a minimum inhibitory concentration (MIC) value of 15.6 microg/m against all species of Candida tested; except C. glabrata (MIC 1.95 microg/mL), and it inhibited the growth of oxacillin-resistant Staphylococcus aureus (MIC 31.2 microg/mL). Only morindone showed activity against all yeast strains (MIC 1.9 microg/mL), and against oxacillin-resistant Staphylococcus aureus (MIC 15 microg/mL).
Borroto
Janetsy
J
Centro de Bioplantas, Universidad de Ciego de Avila, Carretera a Mordn, Km 9. Ciego de Avila, 69450, Cuba.
Salazar
Ricardo
R
Pérez
Alejandro
A
Quiros
Yemeys
Y
Hernandez
Martha
M
Waksman
Noemi
N
Trujillo
Reinaldo
R
D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003462:Cuba; D066298:In Vitro Techniques; D008752:Methylene Chloride / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects
D000880:Anthraquinones; D000890:Anti-Infective Agents; D010936:Plant Extracts; D008752:Methylene Chloride