Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Joost P
JP
Bruggeman
Christopher J
CJ
Bettinger
Robert
R
Langer
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001672:Biocompatible Materials / Q000494:pharmacology*; D020724:Elastomers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D020007:Implants, Experimental; D019344:Lactic Acid / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D040521:Subcutaneous Tissue / Q000187:drug effects; D013997:Time Factors; D014993:Xylitol / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001672:Biocompatible Materials; D020724:Elastomers; D019344:Lactic Acid; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D014993:Xylitol; C067980:CD68 antigen, human; D000097382:CD68 Molecule