Potent in vitro inactivation of both free and cell-associated CCR5- and CXCR4-tropic HIV-1 by common commercial soap bars from South Africa.
We showed herein the potent virucidal effect of soap and water solutions against both CCR5-tropic and CXCR4-tropic cell-free HIV-1 strains, and cytotoxicity for HIV-1-infected lymphocytes during short incubation durations, ranging from 30 seconds to 2 minutes. These observations indicate a rapid inhibitory effect of soap and water on viral infectivity.
Université Paris Descartes (Paris V), and Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France.
Mohammad-Ali
MA
Jenabian
Bertran
B
Auvert
Héla
H
Saïdi
Pascale
P
Lissouba
Mathieu
M
Matta
Laurent
L
Bélec
D019380:Anti-HIV Agents / Q000276:immunology / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D065100:CCR5 Receptor Antagonists; D002470:Cell Survival / Q000187:drug effects; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000821:virology; D019713:Receptors, CCR5 / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors / Q000502:physiology*; D012915:Soaps / Q000494:pharmacology*; D013019:South Africa
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D065100:CCR5 Receptor Antagonists; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D012915:Soaps