Non-invasive Monitoring of Angiogenesis in Cardiology.
Angiogenesis plays an important role in the pathophysiology of atherosclerosis and after myocardial infarction. Furthermore, angiogenesis has been the focus of many therapeutic strategies. In view of that, a direct and clear understanding of the role of these pathways in the living subject is needed. Molecular Imaging has emerged as a powerful tool to study biological processes non-invasively. In this review, evidence will be presented and discussed on the feasibility of different molecular imaging strategies to study the involvement of angiogenic pathways in the assessment of the atherosclerotic disease and as a tool to assess angiogenic therapy. Focus will be placed on those imaging modalities with the potential to be translated to clinical use.
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN.
Martin
M
Rodriguez-Porcel