Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient.
Klebsiella pneumoniae carbapenemase (KPC) 3-producing Escherichia coli was isolated from a carrier of KPC-3-producing K. pneumoniae. The KPC-3 plasmid was identical in isolates of both species. The patient's gut flora contained a carbapenem-susceptible E. coli strain isogenic with the KPC-3-producing isolate, which suggests horizontal interspecies plasmid transfer.
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Moran G
MG
Goren
Yehuda
Y
Carmeli
Mitchell J
MJ
Schwaber
Inna
I
Chmelnitsky
Vered
V
Schechner
Shiri
S
Navon-Venezia
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D003091:Colistin / Q000008:administration & dosage; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004359:Drug Therapy, Combination; D000077727:Ertapenem; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D004927:Escherichia coli Infections / Q000150:complications / Q000378:metabolism / Q000382:microbiology*; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007557:Israel; D007710:Klebsiella Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D010957:Plasmids / Q000235:genetics* / Q000378:metabolism; D014640:Vancomycin / Q000008:administration & dosage; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*; D047090:beta-Lactams / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047090:beta-Lactams; D008795:Metronidazole; D014640:Vancomycin; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae; D000077727:Ertapenem; D003091:Colistin