MicroRNA-140 and the silencing of osteoarthritis.
MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173-1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Moreover, mice lacking miR-140 are dwarf as a consequence of impaired chondrocyte proliferation. This study is the first in vivo demonstration that miR-140 has a critical and nonredundant role in cartilage development and homeostasis.
Araldi
Elisa
E
Endocrine Unit, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts 02114, USA.
Schipani
Ernestina
E
D051722:ADAM Proteins / Q000378:metabolism; D000071116:ADAMTS5 Protein; D000818:Animals; D002356:Cartilage / Q000254:growth & development / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D006132:Growth Plate / Q000254:growth & development; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010003:Osteoarthritis / Q000378:metabolism*
C547828:MIRN140 microRNA, mouse; D035683:MicroRNAs; C544302:Mirn140 microRNA, human; D051722:ADAM Proteins; D000071116:ADAMTS5 Protein; C498489:Adamts5 protein, mouse