Early histopathologic changes in grover disease.
BACKGROUND
Grover disease is a clinicopathologic entity characterized by acantholysis. The histologic changes typically occupy circumscribed foci, therefore early stages could go unnoticed and be misdiagnosed.


OBJECTIVE
To report on early histopathologic changes in Grover disease.


METHODS
We analyzed 22 cases of Grover disease histologically diagnosed at Wake Forest University School of Medicine, NC, between 2000 and 2009. Early changes were defined as elongation of rete ridges and mild focal acantholysis.


RESULTS
Six cases (27%) showed elongation of the rete ridges with focal acantholysis. Mild spongiosis was seen in 4 cases. Superficial perivascular inflammatory infiltrate was found in all cases, 5 of which showed eosinophils.


CONCLUSIONS
These findings may represent a diagnostic clue in cases of early Grover disease, if clinical correlation is made.
Department of Dermatology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain. pritimelwani@comlp.es
Priti M
PM
Melwani
Amy C
AC
Parsons
Omar P
OP
Sangueza
D000051:Acantholysis / Q000276:immunology / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000276:immunology / Q000473:pathology*; D015603:Keratinocytes / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000276:immunology / Q000473:pathology*