[Beta-adrenergic receptors in the cardiovascular system. The participation of propranolol insensitive beta-adrenoceptors in the regulation of the cardiovascular system].
In this paper we described the participation of beta-adrenoceptors in the regulation of the cardiovascular system. We characterized mainly the low-affinty state of beta1-adrenoceptors and beta3-adrenoceptors, which are insensitive to propranolol (the antagonist of beta1-/beta2-adrenoceptors). We also illustrated their function in the healthy and failing heart. In addition the vasodilatory effects of these receptors ligands were described.
Zakład Fizjologii Doświadczalnej, Akademia Medyczna, Białystok. bmalin@amb.edu.pl
Barbara
B
Malinowska
Hanna
H
Kozłowska
Agnieszka
A
Zakrzeska
Grzegorz
G
Kwolek
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism*; D004351:Drug Resistance; D006801:Humans; D011433:Propranolol / Q000627:therapeutic use; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol