In situ remineralisation of enamel and dentin after the use of an amine fluoride mouthrinse in addition to twice daily brushings with amine fluoride toothpaste.
It is often claimed that 3 fluoride moments a day significantly reduce the caries risk compared to 2 daily fluoride moments. However, previous research is not conclusive. Therefore, the aim of this study was to compare the effect on lesion progression of 2 versus 3 fluoride moments a day. A double-blind, randomized, cross-over in situ experiment was designed. The experiment comprised 2 in situ periods of 3 weeks with a washout period of 3 weeks in between. Sixteen participants wore an enamel and a dentine specimen with a preformed lesion placed buccally in their partial prosthesis. The participants brushed twice a day with a 1,400 ppm F (amine fluoride) toothpaste and rinsed once a day with either 250 ppm F (amine F/NaF) or a placebo rinse. At the end of the experiment the specimens were retrieved for fluoride analysis and the assessment of integrated mineral loss with transversal microradiography. The fluoride analysis showed a statistically significant increase in structurally bound fluoride in dentine, but not in enamel, when comparing the fluoride mouthrinse group with the placebo rinse group. The amounts of loosely bound, KOH-soluble fluoride were not different between both groups neither for enamel nor for dentine. In dentine IML gain was significantly (p < 0.05) higher for the fluoride mouthrinse group than for the placebo mouthrinse group. In enamel no statistically significant differences in IML gain were found. For dentine a third fluoride moment may be beneficial in enhancing remineralisation, even under the remineralising conditions as in this study.
Department of Cariology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands. a.lahey@acta.nl
A M G A
AM
Laheij
A J P
AJ
van Strijp
C
C
van Loveren
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000588:Amines / Q000627:therapeutic use*; D000818:Animals; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002417:Cattle; D018592:Cross-Over Studies; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000737:chemistry; D003804:Dentin / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D008852:Microradiography; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D014002:Tin Fluorides / Q000627:therapeutic use*; D014089:Tooth Remineralization / Q000379:methods*; D014100:Toothpastes / Q000627:therapeutic use*
D000588:Amines; D002327:Cariostatic Agents; D005460:Fluorides, Topical; D009067:Mouthwashes; D014002:Tin Fluorides; D014100:Toothpastes; C094808:amine fluoride solution; C075174:amine fluoride gel