Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.
Molecular and Cellular Modeling Group, Heidelberg Institute of Theoretical Studies gGmbH, Heidelberg, Germany.
Divita
D
Garg
Stefan
S
Henrich
Outi M H
OM
Salo-Ahen
Hannu
H
Myllykallio
Maria P
MP
Costi
Rebecca C
RC
Wade
D000494:Allosteric Regulation; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000737:chemistry / Q000494:pharmacology*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D050687:E2F1 Transcription Factor / Q000096:biosynthesis / Q000235:genetics; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D020868:Gene Silencing; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020319:Oligodeoxyribonucleotides, Antisense / Q000737:chemistry / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D011487:Protein Conformation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D034741:RNA, Small Interfering / Q000235:genetics; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*
D000970:Antineoplastic Agents; D050687:E2F1 Transcription Factor; D056572:Histone Deacetylase Inhibitors; D020319:Oligodeoxyribonucleotides, Antisense; D010455:Peptides; D034741:RNA, Small Interfering; D013940:Thymidylate Synthase; D066246:ErbB Receptors; D011493:Protein Kinase C; D018844:Cyclin-Dependent Kinases