Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).
Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.
Dept. of Chemistry, Univ. of Idaho, Moscow, ID-83844, USA.
Michael E
ME
Østergaard
Dale C
DC
Guenther
Pawan
P
Kumar
Bharat
B
Baral
Lee
L
Deobald
Andrzej J
AJ
Paszczynski
Pawan K
PK
Sharma
Patrick J
PJ
Hrdlicka
D015342:DNA Probes / Q000737:chemistry*; D003857:Deoxyuridine / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011721:Pyrenes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014230:Triazoles / Q000737:chemistry*
D015342:DNA Probes; D009841:Oligonucleotides; D011721:Pyrenes; D014230:Triazoles; D003857:Deoxyuridine