Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.
To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocin-induced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.
Department of Endocrinology and Anti-Aging Medicine, Keio University School of Medicine, Tokyo, Japan.
Yasufumi
Y
Seki
Atsuhiro
A
Ichihara
Yuki
Y
Mizuguchi
Mariyo
M
Sakoda
Asako
A
Kurauchi-Mito
Tatsuya
T
Narita
Kenichiro
K
Kinouchi
Kanako
K
Bokuda
Hiroshi
H
Itoh
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose; D001794:Blood Pressure; D001835:Body Weight; D024042:Collagen Type I / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D048289:Imidazolidines / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000235:genetics; D000093342:Prorenin Receptor
D001786:Blood Glucose; D024042:Collagen Type I; D048289:Imidazolidines; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta; D000804:Angiotensin II; C065166:imidapril; D000093342:Prorenin Receptor