Double duty for CCL21 in dendritic cell trafficking.
Mechanisms controlling leukocyte adhesion, propulsion and directional migration have not been fully integrated. In this issue of Immunity, Schumann et al. (2010) propose that DCs swarm to T cell zones using immobilized CCL21 for adhesive random migration and soluble CCL21 for steering.
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. pmm@nih.gov
Philip M
PM
Murphy