Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model.
The mast cell-mediated allergic reactions are involved in many allergic diseases, such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells initiates the process of degranulation, resulting in the release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of gossypin (a biflavonoid) and suramin (a synthetic polysulphonated naphtylurea) on the mast cell-mediated allergy model, and studied the possible mechanism of their action. Both gossypin and suramin inhibited (P<0.001) compound 48/80-induced systemic anaphylaxis reactions, antiprurities (P<0.001) and reduced the histamine release in rats. Further, both showed significant (P<0.001) protection against rat peritoneal mast cells activated by compound 48/80. Thus, our findings provide evidence that gossypin and suramin inhibit mast cell-derived allergic reactions.
Ganapaty
S
S
Pharmacognosy and Phytochemistry Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India. ganapatyseru@yahoo.co.in
Chandrashekhar
V M
VM
Narsu
M Laxshmi
ML
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000982:Antipruritics / Q000494:pharmacology / Q000627:therapeutic use; D001202:Ascitic Fluid / Q000187:drug effects / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006636:Histamine Release / Q000187:drug effects / Q000276:immunology; D006967:Hypersensitivity / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D009589:Nitrogen Oxides / Q000097:blood / Q000378:metabolism; D051381:Rats; D013498:Suramin / Q000494:pharmacology* / Q000627:therapeutic use; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D018926:Anti-Allergic Agents; D000982:Antipruritics; D005419:Flavonoids; D009589:Nitrogen Oxides; D003189:p-Methoxy-N-methylphenethylamine; D013498:Suramin; C022944:gossypin; C039900:nitroxyl