An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds.
A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 minutes, followed by a brief aqueous workup.
Majireck
Max M
MM
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylania 16802 USA.
Witek
Jason A
JA
Weinreb
Steven M
SM