Delay correction for the assessment of blood-brain barrier permeability using first-pass dynamic perfusion CT.
Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.
Department of Radiology, Neuroradiology Section, University of California, San Francisco, San Francisco, California, USA.
T
T
Schneider
J
J
Hom
J
J
Bredno
J W
JW
Dankbaar
S-C
SC
Cheng
M
M
Wintermark
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D001812:Blood-Brain Barrier / Q000502:physiology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D002199:Capillary Permeability / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D055420:Perfusion Imaging / Q000379:methods / Q000592:standards; D011829:Radiation Dosage; D012189:Retrospective Studies; D020521:Stroke / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards*