Invasive aspergillosis after pandemic (H1N1) 2009.
We report 2 patients with invasive aspergillosis after infection with pandemic (H1N1) 2009. Influenza viruses are known to cause immunologic defects and impair ciliary clearance. These defects, combined with high-dose corticosteroids prescribed during influenza-associated adult respiratory distress syndrome, may be novel risk factors predisposing otherwise immunocompetent patients to invasive aspergillosis.
New York-Presbyterian Hospital, New York, New York, USA.
Asma
A
Lat
Nahid
N
Bhadelia
Benjamin
B
Miko
E Yoko
EY
Furuya
George R
GR
Thompson
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D001232:Aspergillus fumigatus; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007121:Immunocompetence; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications* / Q000276:immunology / Q000821:virology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000209:etiology; D012307:Risk Factors; D013997:Time Factors
D000935:Antifungal Agents; D005938:Glucocorticoids; D008775:Methylprednisolone