Surgical management of primary non-small-cell carcinoma of lung with synchronous solitary brain metastasis: local experience.
OBJECTIVE
To report the surgical experience in the management of patients with synchronous primary lung cancer and solitary brain metastasis.


METHODS
Retrospective cohort study.


METHODS
Regional hospital, Hong Kong.


METHODS
Seventeen patients with synchronous primary lung cancer and solitary brain metastasis were treated by pulmonary resection and neurosurgical intervention between 1994 and 2007.


RESULTS
Median patient survival was 52 months (95% confidence interval, 9-95 months) and the 5-year survival was 27%. The univariate analysis yielded no significant prognostic factor. Four out of six patients who had lymph node metastases developed tumour recurrence.


CONCLUSIONS
In view of encouraging survival results, aggressive therapy including pulmonary resection and neurosurgical intervention should be recommended for patients with synchronous presentation with primary lung cancer and solitary brain metastasis.
Lo
C K
CK
Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Yu
C H
CH
Ma
C C
CC
Ko
K M
KM
Leung
Samuel C L
SC
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D003952:Diagnostic Imaging; D005260:Female; D006723:Hong Kong; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome