Organ donation and time to procurement: late is not too late.
BACKGROUND
No consensus exists as to the maximal period of time allowable after brain death (BD) before organ procurement rates begin to deteriorate. The aim of this study was to examine organ procurement rates as a function of time after BD.


METHODS
After institutional review board approval, all consented donors from 2006 through 2008 were identified from the regional Organ Procurement Organization. Demographics, organ procurement data, and the time from BD to procurement were abstracted. The organ's procured to consented ratio was analyzed from the time of BD to organ recovery in 6-hour intervals.


RESULTS
Of 1,554 consented organ donors, 678 (46.3%) were trauma patients. Mean age was 37.1 years +/- 17.6 years; 62.6% were male. The mean time from BD to procurement was 34.5 hours +/- 19.8 hours. A total of 3,340 (44.8%) organs (kidneys 95.4%, livers 80.5%, hearts 36.0%, pancreas 24.9%, lungs 13.0%, and intestines 2.9%) were procured out of the 7,451 that were consented for. Poor organ function was the primary reason for nonprocurement. For each organ analyzed individually and all organs combined, there was no decrease in the procurement to consented ratio with increasing time after BD. There was also no increase in the number of organs nonprocured because of poor organ function.


CONCLUSIONS
Increasing time interval between BD and organ procurement was not associated with decreased organ procurement rates or an increased number of nonsalvageable organs because of poor organ function. Further investigation of the impact of this delay on long-term organ function is warranted.
Inaba
Kenji
K
Division of Trauma and Surgical Critical Care, University of Southern California, 1200 North State Street, Room CL5100, Los Angeles, CA 90033-4525, USA. kinaba@surgery.usc.edu
Branco
Bernardino C
BC
Lam
Lydia
L
Salim
Ali
A
Talving
Peep
P
Plurad
David
D
Green
Donald J
DJ
Demetriades
Demetrios
D
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001926:Brain Death; D002423:Cause of Death; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D013997:Time Factors; D020858:Tissue and Organ Harvesting / Q000379:methods*; D009927:Tissue and Organ Procurement / Q000379:methods*