The role of advanced MR methods in the diagnosis of cerebral amyloidoma.
Amyloidoma is a term referring to a tumor-like deposition of extracellular insoluble fibrillar protein. Tumor-like amyloid formation in the brain had been described in isolated cases. However no advanced radiological studies to characterize these lesions have been reported. In the report, we have describe a 59-year-old woman, presented several months prior to diagnosis with memory decline, dizziness, walking instability, and speech difficulties. MRI revealed a left basal ganglia lesion with an intraventricular component. The patient underwent a stereotactic biopsy, which confirmed the diagnosis of amyloidoma, an extensive radiographic characterization of amyloidoma using advanced MR techniques was done, including magnetic resonance spectroscopy, dynamic susceptibility contrast, susceptibility weighted image (SWI), and magnetization transfer (MTR). All advanced MR techniques were able to characterize the amyloidoma as a non-neoplastic process. This is an example where such methods can be used for differential diagnosis of atypical brain lesions.
Neurosurgical Department, Tel Aviv Medical Center, Tel Aviv, Israel. nossek@gmail.com
Erez
E
Nossek
Dafna Ben
DB
Bashat
Moran
M
Artzi
Keren
K
Rosenberg
Irith
I
Lichter
Orit
O
Shtern
Haim Ben
HB
Ami
Orna
O
Aizenstein
Euvgeni
E
Vlodavsky
Marius
M
Constantinescu
Zvi
Z
Ram
D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged