Effect of a soluble cocoa fiber-enriched diet in Zucker fatty rats.
The effects of a soluble cocoa fiber (SCF) were studied in Zucker fatty rats. Two groups of Zucker fatty rats were fed the following diets: standard diet and 5% SCF-enriched diet. A group of Zucker lean rats fed the standard diet was used for results comparison with obese Zucker animals. Solid and liquid intakes, body weight, plasma glucose, lipid profile, and systolic (SBP) and diastolic (DBP) blood pressure were recorded weekly. At the end of the experimental period insulin was determined, and fat apparent digestibility (FAD) and insulin resistance were calculated. The Zucker fatty rats fed 5% SCF-enriched diet showed less weight gain and food intake than those fed the standard diet. The group fed the fiber-enriched diet showed lower values of the total cholesterol/high-density lipoprotein cholesterol ratio and triglyceride levels than the standard group. FAD was also lower in the fiber group. Both SBP and DBP were decreased. In addition, SCF reduced plasma glucose and insulin, and as a consequence the insulin resistance was also decreased. Our data demonstrate that SCF resulted in an improvement of the studied risk factors associated with cardiometabolic disorders.
Departamento de Farmacología, Faculta de Medicina, Universidad Complutense, Madrid, Spain.
David
D
Sánchez
Leila
L
Moulay
Begoña
B
Muguerza
Mar
M
Quiñones
Marta
M
Miguel
Amaya
A
Aleixandre
D000818:Animals; D001786:Blood Glucose; D001794:Blood Pressure; D002099:Cacao / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D011897:Random Allocation; D051381:Rats; D011924:Rats, Zucker; D015430:Weight Gain
D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin; D002784:Cholesterol