Dopamine D(1) receptor binding in the anterior cingulate cortex of patients with obsessive-compulsive disorder.
Functional neuroimaging studies in patients with obsessive-compulsive disorder (OCD) suggest there is a hyperactivation of the anterior cingulate cortex (ACC) during provocation of symptoms and conflict-inhibition tasks. Since dopamine, acting through D(1) receptors is suggested to modulate ACC activity, we hypothesised that there would be an altered D(1) binding potential (BP) in the ACC of OCD patients. Using [(11)C]-SCH23390 and positron emission tomography, we report significantly reduced D(1) BP in seven drug-free OCD patients compared with matched healthy controls. These findings suggest mesocortical dopamine inputs via D(1) receptors may play a role in the aetiology of OCD.
Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia. jamesso@unimelb.edu.au
James S
JS
Olver
Graeme
G
O'Keefe
Gareth R
GR
Jones
Graham D
GD
Burrows
Henri J
HJ
Tochon-Danguy
Uwe
U
Ackermann
Andrew M
AM
Scott
Trevor R
TR
Norman
D000328:Adult; D001552:Benzazepines / Q000493:pharmacokinetics; D001931:Brain Mapping; D002247:Carbon Isotopes / Q000493:pharmacokinetics; D018492:Dopamine Antagonists / Q000493:pharmacokinetics; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography; D011485:Protein Binding / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D017447:Receptors, Dopamine D1 / Q000378:metabolism*
D001552:Benzazepines; D002247:Carbon Isotopes; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390