Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy.
Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-8849, USA. Sherwood.Brown@UTSouthwestern.edu
E Sherwood
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Brown
Carlos
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Tirado
Abu
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Minhajuddin
Maureen
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Hillhouse
Bryon
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Adinoff
Walter
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Ling
Geetha
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Doraimani
Christie
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Thomas
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D054577:National Institute on Drug Abuse (U.S.); D009293:Opioid-Related Disorders / Q000208:ethnology / Q000534:rehabilitation*; D016032:Randomized Controlled Trials as Topic; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000208:ethnology; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
D009292:Narcotic Antagonists; D002047:Buprenorphine