[Effect of total saponins from rhizomes and flowers of Panax notoginseng on tumor cell induced platelet aggregation].
OBJECTIVE
To investigate the effects of total saponins from rhizomes and flowers of Panax notoginseng on tumor cell induced platelet aggregation (TCIPA).


METHODS
MDA-MB-231 breast carcinoma was applied as inductor and the platelet aggregation were investigated by Born's method in vitro and in vivo.


RESULTS
Saponins from the flowers of Panax notoginseng inhibited TCIPA at the dose of 120, 240, 480 mg/L respectively in vitro and in vivo. Saponins from rhizomes of Panax notoginseng inhibited TCIPA only at its high dose in vivo.


CONCLUSIONS
The saponins from Panax notoginseng has a dose-dependent inhibition of TCIPA. It may be a new class of antimetastatic agent.
Teaching Experimental Center, Shanghai University of TCM, Shanghai 201203, China. keyan111@yahoo.com.cn
Yan
Y
Ke
Jia-Ye
JY
Jiang
Xian-Zhen
XZ
Wang
Xiong-Yi
XY
Zeng
Chun-Yun
CY
Zhu
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D004305:Dose-Response Relationship, Drug; D005260:Female; D035264:Flowers / Q000737:chemistry; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D053723:Panax notoginseng / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011897:Random Allocation; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010975:Platelet Aggregation Inhibitors; D012503:Saponins