A case of multiple endocrine neoplasia type 1 with primary liver gastrinoma.
Gastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in patients with multiple endocrine neoplasia type 1 (MEN 1). Primary hepatic gastrinomas in MEN 1 are very rare, with no previous reports published in the literature. We reported the case of a 39 yr old female patient with a history of repeated peptic ulcers and a hypoglycemia episode. Abdominal CT indicated a well-defined liver mass and a pancreatic head mass. Somatostatin-receptor scintigraphy with [(111)In] DTPA octreotide demonstrated a strong uptake of the radiotracer in the left lateral segment at the site of the hepatic mass. After operation, immunohistochemical staining was consistent with pancreatic insulinoma and primary hepatic gastrinoma. As the liver is a common site of metastases from gastrinoma, primary liver gastrinoma has not yet been reported with MEN 1. We diagnosed this patient using immunohistochemical studies and treated this patient by hepatic segmentectomy.
Lee
Sul Ra
SR
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
Choi
Moon Chan
MC
Ahn
Kyu Jeung
KJ
D000328:Adult; D005260:Female; D015408:Gastrinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007340:Insulinoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D015412:Mastectomy, Segmental; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D010437:Peptic Ulcer / Q000209:etiology; D014057:Tomography, X-Ray Computed