Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.
Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Xiao
X
Luo
Jian-Xin
JX
Pu
Wei-Lie
WL
Xiao
Yong
Y
Zhao
Xue-Mei
XM
Gao
Xiao-Nian
XN
Li
Hai-Bo
HB
Zhang
Yuan-Yuan
YY
Wang
Yan
Y
Li
Han-Dong
HD
Sun
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal