Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells.
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.
Hsu
Yuan-Man
YM
Department of Biological Science, China Medical University, Taichung, Taiwan, ROC.
Lai
Chih-Ho
CH
Su
Chiu-Hsiang
CH
Kuo
Wei-Wen
WW
Kuo
Chao-Lin
CL
Hsu
Cheng-Kuang
CK
Wang
Chien-Kuo
CK
Chang
Ching-Yao
CY
Chung
Jing-Gung
JG
D000230:Adenocarcinoma / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000473:pathology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
D010936:Plant Extracts