Designing the modern pump: engineering aspects of continuous subcutaneous insulin infusion software.
Insulin delivery systems attracted the efforts of biological, mechanical, electrical, and software engineers well before they were commercially viable. The introduction of the first commercial insulin pump in 1983 represents an enduring milestone in the history of diabetes management. Since then, pumps have become much more than motorized syringes and have assumed a central role in diabetes management by housing data on insulin delivery and glucose readings, assisting in bolus estimation, and interfacing smoothly with humans and compatible devices. Ensuring the integrity of the embedded software that controls these devices is critical to patient safety and regulatory compliance. As pumps and related devices evolve, software engineers will face challenges and opportunities in designing pumps that are safe, reliable, and feature-rich. The pumps and related systems must also satisfy end users, healthcare providers, and regulatory authorities. In particular, pumps that are combined with glucose sensors and appropriate algorithms will provide the basis for increasingly safe and precise automated insulin delivery-essential steps to developing a fully closed-loop system.
Welsh
John B
JB
Diabetes, Medtronic Inc., 18000 Devonshire Street, Northridge, CA 91325, USA.
Vargas
Steven
S
Williams
Gary
G
Moberg
Sheldon
S
D040421:Cell Phone; D003199:Computer Systems; D017147:Defibrillators, Implantable; D004305:Dose-Response Relationship, Drug; D004738:Engineering / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D018570:Risk Assessment; D012449:Safety; D012984:Software
D007004:Hypoglycemic Agents; D007328:Insulin