Direct observation of a transient polymorph during crystallization.
Application of a technique developed for in situ solid-state (13)C NMR studies of crystallization processes reveals direct evidence that crystallization of glycine from a methanol/water solution involves the initial transient formation of the beta polymorph, which then undergoes a solution-mediated polymorphic transformation to yield the more stable alpha polymorph.
School of Chemistry, Cardiff University, Park Place, Cardiff, Wales, CF10 3AT, UK.
Colan E
CE
Hughes
Kenneth D M
KD
Harris