Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.
The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells, OSTalpha-OSTbeta protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids. This article reviews recent results including studies of knockout mouse models that provide new insights to the role of OSTalpha-OSTbeta in the compartmentalization and metabolism of these important lipids.
Department of Internal Medicine, Section on Gastroenterology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. pdawson@wfubmc.edu
Paul A
PA
Dawson
Melissa L
ML
Hubbert
Anuradha
A
Rao
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D051379:Mice; D013256:Steroids / Q000378:metabolism*
D001647:Bile Acids and Salts; D026901:Membrane Transport Proteins; D013256:Steroids; C476575:organic solute transporter alpha, human; C476576:organic solute transporter alpha, mouse; C476577:SLC51B protein, human; C476578:organic solute transporter beta, mouse