Autoantibodies to coagulation factors.
Tolerance to autoantigens such as coagulation factors is the result of censoring mechanisms occurring at the level of the thymus and bone marrow for autoreactive T and B cells, respectively. In addition, peripheral mechanisms, both intrinsic and extrinsic further control activation of autoreactive cells that have escaped central deletion. Emergence of autoimmunity can occur from disturbances of these control mechanisms by a number of events, many of which are incompletely understood. Insight into this clinically important field is expected from exploitation of recent animal models.
Saint-Remy
J-M R
JM
Center for Molecular and vascular Biology, Campus Gasthuisberg, University of Leuven, Leuven, Belgium. jeanmarie.saint-remy@med.kuleuven.ac.be
D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity; D005169:Factor VIII / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D005169:Factor VIII