Afferent control of locomotor CPG: insights from a simple neuromechanical model.
A simple neuromechanical model has been developed that describes a spinal central pattern generator (CPG) controlling the locomotor movement of a single-joint limb via activation of two antagonist (flexor and extensor) muscles. The limb performs rhythmic movements under control of the muscular, gravitational and ground reaction forces. Muscle afferents provide length-dependent (types Ia and II) and force-dependent (type Ib from the extensor) feedback to the CPG. We show that afferent feedback adjusts CPG operation to the kinematics and dynamics of the limb providing stable "locomotion." Increasing the supraspinal drive to the CPG increases locomotion speed by reducing the duration of stance phase. We show that such asymmetric, extensor-dominated control of locomotor speed (with relatively constant swing duration) is provided by afferent feedback independent of the asymmetric rhythmic pattern generated by the CPG alone (in "fictive locomotion" conditions). Finally, we demonstrate the possibility of reestablishing stable locomotion after removal of the supraspinal drive (associated with spinal cord injury) by increasing the weights of afferent inputs to the CPG, which is thought to occur following locomotor training.
Markin
Sergey N
SN
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Klishko
Alexander N
AN
Shevtsova
Natalia A
NA
Lemay
Michel A
MA
Prilutsky
Boris I
BI
Rybak
Ilya A
IA
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D005121:Extremities / Q000502:physiology; D008124:Locomotion / Q000502:physiology*; D008322:Mammals; D008954:Models, Biological; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009474:Neurons / Q000502:physiology; D046709:Pattern Recognition, Physiological / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology; D013119:Spinal Cord Injuries / Q000503:physiopathology