Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis.
BACKGROUND
Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis.


METHODS
We conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing.


RESULTS
All four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and the most significant haplotype had a p value of 0.0045. We did not see any SNP that was more significant in the recurrent cases.


CONCLUSIONS
We concluded that MMP-9 gene polymorphisms may influence susceptibility to the development of chronic rhinosinusitis with nasal polyposis in Chinese population.
Wang
Ling-Feng
LF
Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien
Chen-Yu
CY
Tai
Chih-Feng
CF
Kuo
Wen-Rei
WR
Hsi
Edward
E
Juo
Suh-Hang Hank
SH
D056151:Airway Remodeling; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002908:Chronic Disease; D006239:Haplotypes; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D009298:Nasal Polyps / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012008:Recurrence; D012852:Sinusitis / Q000235:genetics
D020780:Matrix Metalloproteinase 9