Microdeletion of chromosome 15q24.3-25.2 and orofacial clefting.
We report a case of de novo microdeletion of 15q24.3-q25.2 in an infant with orofacial cleft and general hypotonia and suggest that this may be a critical region in orofacial development. In addition, this case highlights the usefulness of comparative genomic microarray in the evaluation of children with congenital anomalies with such defects.
Sing
Bindya
B
Song
Dongli
D
DeSandre
Glenn
G
Govindaswami
Balaji
B
Rosenthal
Scott
S
Gunn
Shelly
S
Wallerstein
Robert
R
D000015:Abnormalities, Multiple / Q000235:genetics; D002681:China; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D003952:Diagnostic Imaging; D006801:Humans; D007231:Infant, Newborn; D008297:Male