Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules.
The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.
Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
Shuk-Yan
SY
Cheng
Marcus Chun-Wah
MC
Yuen
Pik-Ling
PL
Lam
Roberto
R
Gambari
Raymond Siu-Ming
RS
Wong
Gregory Yin-Ming
GY
Cheng
Paul Bo-San
PB
Lai
See-Wai
SW
Tong
Kit-Wah
KW
Chan
Fung-Yi
FY
Lau
Stanton Hon-Lung
SH
Kok
Kim-Hung
KH
Lam
Chung-Hin
CH
Chui
D000068579:Celecoxib; D048271:Chitosan / Q000138:chemical synthesis* / Q000494:pharmacology*; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D048271:Chitosan; D000068579:Celecoxib