Early diagnostic markers for contrast nephropathy in patients undergoing coronary angiography.
The present work aimed to prove the usage of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for kidney injury and to assess the relationship between NGAL and serum creatinine and cystatin C in patients with normal serum creatinine undergoing percutaneous coronary angiography. Thirty patients with normal serum creatinine undergoing coronary angiography were enrolled. Estimation of blood glucose, glycosylated hemoglobin, lipid profile, creatinine, NGAL, and cystatin C were done before coronary angiography for all patients. Serum creatinine, NGAL and cystatin C were evaluated again at 4 and 24 hours after coronary angiography. There was a significant increase in serum NGAL level 4 hours and 24 hours after coronary interventions compared to the baseline value before coronary angiography. Before coronary angiography, serum NGAL was positively correlated with serum creatinine, and cystatin C.


CONCLUSIONS
Serum NGAL and cystatin C could be valuable in the detection of early renal impairment after coronary angiography.
Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Egypt. olfatshaker@yahoo.com
Olfat G
OG
Shaker
Amal
A
El-Shehaby
Mohamed
M
El-Khatib
D000209:Acute-Phase Proteins; D015415:Biomarkers / Q000097:blood; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000097:blood*
D000209:Acute-Phase Proteins; D015415:Biomarkers; D003287:Contrast Media; D055316:Cystatin C; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine