[Primary pulmonary synovial sarcoma confirmed by gene expression analysis].
We report a patient who was diagnosed with synovial sarcoma based on gene expression analysis. A 39-year-old male visited a local hospital due to left chest pain. Chest compued tomography (CT) showed a lung tumor located mainly at the lingula of the left lung, and extending to the bifurcation of the upper and lower lobar bronchi. Left pneumonectomy was performed. Pathological examination showed a mesenchymal tumor consisting of short-spindle, small, round cells, and the differentiation between synovial sarcoma and peripheral neuroectodermal tumor was necessary. RT-PCR to examine the gene expression of cells revealed a SYT-SSX fusion gene, and a diagnosis of primary synovial sarcoma of the lung was made.
Sato
Seijiro
S
Department of Thoracic Surgery, Japanese Red Cross Nagaoka Hospital, Nagaoka, Japan.
Hosaka
Yasuko
Y
Togashi
Kenichi
K
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics*
D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein