Mesalamine lung toxicity.
Lung toxicity associated with 5-aminosalicylate (5-ASA) agents is very rare. We report the case of a 48-year-old man with ulcerative colitis who developed progressive shortness of breath while taking oral mesalamine. Chest imaging revealed a ground glass appearance in patchy areas distributed throughout the lung. He had a restrictive ventilatory defect with reduced diffusion capacity. He improved rapidly afterthis drug was discontinued. Mesalamine-induced lung damage must be considered in patients who develop unexplained respiratory symptoms while taking this agent.
N University of Connecticut Health Center, USA.
Neha
N
Jain
Carol
C
Petruff
Tapas
T
Bandyopadhyay
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D004417:Dyspnea / Q000139:chemically induced; D006801:Humans; D008168:Lung / Q000187:drug effects; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine