Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time-signal intensity curves for differentiating between active and inactive Crohn's disease.
OBJECTIVE
To assess Crohn's disease (CD) activity through analysis of time-signal intensity curves and quantitative contrast-enhancement parameters on dynamic contrast-enhanced MRI.


METHODS
70 patients (male:female = 44:26, age 15-45 years, mean 27.8 years) with biopsy-proven clinically active or inactive CD, underwent dynamic contrast-enhanced MRI after oral administration of iso-osmotic solution. Time-signal intensity curves were classified according to their shape as type I (early upslope with late plateau) and type II (slow contrast material wash-in with late wash-out). Curve parameters such as maximum enhancement (ME), the ratio between late and ME (LE/ME), and UpSlope (US) were compared between patients with active and inactive CD (two-tailed Mann-Whitney test). Sensitivity, specificity, and cut-off for each parameter were calculated by means of receiver operating characteristic curve (ROC) analysis.


RESULTS
53/53 patients with active CD and 17/17 with inactive CD showed type I and type II curves, respectively. ME, LE/ME, and US were significantly higher in active than in inactive CD. ME, LE/ME, and US had sensitivity and specificity of 100%:100%:100% and 100%:83%:100% with cut-offs of 135.5:0.8909:2, respectively.


CONCLUSIONS
Qualitative and quantitative analysis of time-signal intensity curves obtained with dynamic contrast-enhanced MRI allow reliable noninvasive differentiation between active and inactive CD.
Department of Radiology, University of Pisa, Italy. s.giusti@med.unipi.it
Sabina
S
Giusti
Lorenzo
L
Faggioni
Emanuele
E
Neri
Elena
E
Fruzzetti
Letizia
L
Nardini
Santino
S
Marchi
Carlo
C
Bartolozzi
D000293:Adolescent; D000328:Adult; D003287:Contrast Media; D003424:Crohn Disease / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007421:Intestine, Small; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol