Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness.
A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.
Krishnamurthy
Sriram
S
Department of Pediatric Medicine, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, India. drsriramk@yahoo.com
Seth
Anju
A
Puri
Archana
A
Anand
Rama
R
Aneja
Satinder
S
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy* / Q000473:pathology; D010048:Ovarian Cysts / Q000188:drug therapy* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013577:Syndrome; D013963:Thyroid Hormones / Q000627:therapeutic use*; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D013963:Thyroid Hormones; D013974:Thyroxine