Cytotoxic activity of trijugin-type limonoids from Cipadessa baccifera.
Two new trijugin-type limonoids, cipatrijugins E and F (1 and 2), together with the known cipatrijugins A and D (3-4), were isolated from the stem bark of Cipadessa baccifera. All structures were elucidated by spectroscopic analysis. The in vitro cytotoxicity of compounds 1-4 was also tested. Compound 1 showed significant in vitro cytotoxicity against MCF-7, SW480, HL-60, and SMMC-7721 cells, with IC(50) values of 5.0, 6.6, 4.5, and 21.6 µM, respectively.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Jing
J
Ning
Ying-Tong
YT
Di
Yuan-Yuan
YY
Wang
Hong-Ping
HP
He
Xin
X
Fang
Yan
Y
Li
Shun-Lin
SL
Li
Xiao-Jiang
XJ
Hao
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D036701:Limonins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; D010936:Plant Extracts