[Uveitis in juvenile idiopathic arthritis].
Anterior uveitis usually occurs in the context of juvenile idiopathic arthritis in about 10% of patients. Frequency is dependent on JIA subtype. Uveitis is most commonly found in patients with extended oligoarthritis (up to 25%) and early-age onset of arthritis. As the uveitis is usually without externally recognisable signs and often leads to ocular complications, all JIA patients should undergo regular ophthalmological examinations to ensure the promptest possible diagnosis and therapy. About 25% of uveitis patients have a complicated clinical course and require systemic immunosuppression. Immunosuppressive therapy should be started as early as possible if the dosage of topical glucocorticoids is not less than 3 drops per day and systemic glucocorticoid therapy is not less than 0.1 mg / kg body weight after 12 weeks. Methotrexate is commonly started as a first line immunosuppressive therapy. In the case of treatment failure, additional therapy can consist of combination therapy with cyclosporine A and biologicals. The main therapeutic goal is to achieve remission. Management of the typical vision-threatening complications such as cataract, glaucoma, ocular hypotension, and macular edema is particularly challenging.
Augenabteilung am St. Franziskus Hospital Münster, Hohenzollernring 74, Münster, Germany. carsten.heinz@uveitis-zentrum.de
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Heinz
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Heiligenhaus
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Kümmerle-Deschner
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Foeldvari
D000284:Administration, Oral; D001171:Arthritis, Juvenile / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D001688:Biological Products / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003299:Cooperative Behavior; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D033183:Interdisciplinary Communication; D009883:Ophthalmic Solutions; D010348:Patient Care Team; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
D001688:Biological Products; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions