Elevation of B-type natriuretic peptide is a sensitive marker of left ventricular diastolic dysfunction in patients with maintenance haemodialysis.
OBJECTIVE
To determine the clinical value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction (LVDD) associated with maintenance haemodialysis (MHD) population.


METHODS
Plasma BNP was determined in 59 MHD patients with normal ejection fraction. The ratio of early to late annular velocity (E'/A') was determined by tissue Doppler imaging as a parameter of diastolic function.


RESULTS
LVDD occurred in 66% of the patients. Receiver-operating characteristic curve analyses identified a cut-off of 353.6 pg ml(-1) as the one with the highest sensitivity and specificity for detecting LVDD.


CONCLUSIONS
Plasma BNP may serve as a potential biomarker in diagnosing LVDD in MHD patients with normal systolic function.
Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing, Jiangsu Province, China.
Hong
H
Liu
Ying-Zi
YZ
Zhang
Min
M
Gao
Bi-Cheng
BC
Liu
D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012372:ROC Curve; D006435:Renal Dialysis; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain