Palisaded neutrophilic and granulomatous dermatitis in association with sarcoidosis.
Palisaded and neutrophilic granulomatous dermatitis (PNGD) has been associated with many conditions including rheumatoid arthritis, systemic lupus erythematosus, systemic vasculitis, and other diseases with circulating immune complexes. Lymphoproliferative conditions, bacterial endocarditis, and various drugs can also induce this condition. Many patients also have symmetric polyarthritis with various serological abnormalities. We present a case of a 46-year-old female who presented with painful erythematous annular plaques and nodules on her legs. The lesions started a week prior to visit and increased in number over the course of the week. The patient had an established history of sarcoidosis with past episodes of uveitis and erythema nodosum. The histopathological findings included a diffuse pandermal infiltrate mostly composed of neutrophils, nuclear debris, and strands of deeply eosinophilic degenerated collagen. Vasculitis was not present. No significant increase in dermal mucin was detected. Based on the clinical and pathological findings, the patient was diagnosed with late-stage PNGD. To our knowledge, this is the first case of PNGD described in an adult patient of sarcoidosis.
Department of Dermatology, Tufts Medical Center and Caris/Cohen Dx, Boston, MA 02464, USA. mmahmoodi@cariscohendx.com
Mandana
M
Mahmoodi
Adeel
A
Ahmad
Cheryl
C
Bansal
Carrie Ann
CA
Cusack
D003872:Dermatitis / Q000150:complications / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications / Q000473:pathology*