[Association between the risk factors of cardiovascular diseases and insulin resistance].
OBJECTIVE
To explore the association between risk factors of cardiovascular diseases (CVD) and insulin resistance in a cross-sectional study.


METHODS
An investigation on risk factors of CVD was carried out using stratified-random sampling method among 1475 participants in Beijing. Homeostasis model assessment index (HOMA) was calculated to assess the insulin resistance in 1359 non-diabetic subjects aged 25 - 64 years. Insulin resistance was defined as HOMA index (fasting glucose in mmol/L x fasting insulin in mU/L/22.5) in the top quartile of the studied population.


RESULTS
The degree of correlation between risk factors and natural logarithm of HOMA index in descending order were glucose, body mass index (BMI), triglyceride (TG), waist circumstance, high density lipoprotein-cholesterol (HDL-C), uric acid, diastolic blood pressure, systolic blood pressure and total cholesterol (TC) (all P < 0.01). After adjusting factors as sex and age, glucose (r = 0.49), BMI (r = 0.44), TG (r = 0.44), waist circumstance (r = 0.41), uric acid (r = 0.33) and HDL-C (r = -0.32), the systolic blood pressure (r = 0.20), diastolic blood pressure (r = 0.18) and TC (r = 0.16) were independently correlated with HOMA index (P < 0.001). Sex (OR = 1.75), low HDL-C (OR = 1.80), hyperuricemia (OR = 2.11), high TG (OR = 2.14) and central obesity (OR = 2.68) appeared to be independently correlated to insulin resistance in multiple logistic regression analysis.


CONCLUSIONS
The risk factors of CVD as low HDL-C, high TG, central obesity and hyperuricemia were independently correlated to insulin resistance.
Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung & Blood Vessel Diseases, Beijing 100029, China. wmiao@yeah.net
Miao
M
Wang
Dong
D
Zhao
Wei
W
Wang
Jing
J
Liu
Jun
J
Liu
Jia-yi
JY
Sun
Yan
Y
Li
Lan-ping
LP
Qin
Zhao-su
ZS
Wu
D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D007328:Insulin