Triamcinolone-impregnated nasal dressing following endoscopic sinus surgery: a randomized, double-blind, placebo-controlled study.
OBJECTIVE
To evaluate the impact of steroid-impregnated absorbable nasal dressing on wound healing and surgical outcomes after endoscopic sinus surgery (ESS).


METHODS
A prospective, randomized, double-blinded, placebo-controlled trial.


METHODS
Chronic rhinosinusitis patients with polyposis who were to undergo bilateral endoscopic sinus surgery were recruited and randomized to receive triamcinolone-impregnated bioresorbable dressing (Nasopore; Stryker Canada, Hamilton, Ontario, Canada) in one nasal cavity and saline-impregnated dressing contralaterally. Postoperative healing assessments of edema, crusting, secretions, and scarring were done at postoperative days 7, 14, 28 and at 3 and 6 months using validated Lund-Kennedy and Perioperative Sinus Endoscopy (POSE) scores.


RESULTS
Analysis of 19 enrolled patients having completed observation shows no significant difference between the cavity scores preoperatively using both the POSE and Lund-Kennedy scores. There was, however, a statistically significant difference at day 7 and 14 in both the Lund-Kennedy (P = .04 and P = .03, respectively) and POSE scores (P = .03 and P = .001, respectively) for the treatment and control groups, and a significant difference was also detected between the groups at 3- and 6-month observations (Lund-Kennedy, P = .007 and P = .02, respectively; POSE, P = .049 and P = .01, respectively).


CONCLUSIONS
Data analysis suggests a significant improvement in early postoperative healing in nasal cavities receiving triamcinolone-impregnated absorbable nasal packing following ESS and is also associated with improved healing up to 6 months postoperatively.
Division of Otolaryngology, Head and Neck Surgery, University of Alberta, Edmonton, Alberta, Canada. dcote@post.harvard.edu
David W J
DW
Côté
Erin D
ED
Wright
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001458:Bandages; D004311:Double-Blind Method; D004724:Endoscopy; D006801:Humans; D009298:Nasal Polyps / Q000601:surgery*; D010256:Paranasal Sinuses / Q000601:surgery*; D010919:Placebos; D011446:Prospective Studies; D012852:Sinusitis / Q000601:surgery*; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D010919:Placebos; D014221:Triamcinolone