Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.
Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described, using the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines.
Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987, USA.
Zhang
Z
Liu
Adel
A
Nefzi
D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008968:Molecular Conformation; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry*; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D010880:Piperidines; D011760:Pyrrolidinones; D054852:Small Molecule Libraries