Renal transplant in Wegener's granulomatosis compared to microscopic polyangiitis.
OBJECTIVE
Antineutrophil cytoplasmic antibody-associated vasculitis is an important cause of endstage renal disease. Our aim was to investigate how the underlying vasculitis diagnosis may influence outcomes following renal transplant.


METHODS
We undertook a retrospective cohort study of patients who underwent renal transplant at the Johns Hopkins Hospital between 1999 and 2008.


RESULTS
Detailed followup data were available for 11 patients with Wegener's granulomatosis (WG) and 6 with microscopic polyangiitis (MPA), representing 799 patient-months of observation. Patients with WG remained on hemodialysis longer (and may have had slightly worse renal outcomes following transplant) than patients with MPA. Four patients with WG experienced adverse events following renal transplant: 2 experienced rejection and 2 vasculitis flare. Among the patients with MPA, there was 1 episode of rejection and no vasculitis flare.


CONCLUSIONS
Whether outcomes following renal transplant may be influenced by the underlying diagnosis of vasculitis merits further study.
Division of Nephrology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Duvuru
D
Geetha
Mark
M
Haas
Edward S
ES
Kraus
Hamid
H
Rabb
Philip
P
Seo
D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001808:Blood Vessels / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000473:pathology / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D055953:Microscopic Polyangiitis / Q000097:blood / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
D019268:Antibodies, Antineutrophil Cytoplasmic