Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease.
Interleukin-1 receptor antagonist (IL-1Ra) is a good indicator of disease activity in patients with systemic lupus erythematosus (SLE). Glucocorticosteroids are the most frequently used drugs in SLE. Our goal was to compare IL-1Ra activity in SLE patients with and without renal involvement and to determine the effect of different dosage of glucocorticosteroids used in 17 patients with active SLE without nephritis, 7 patients with inactive lupus nephritis (LN), and 8 patients with active LN, along with 10 healthy controls. IL-1Ra levels were measured in the serum of SLE patients by Human Luminex [100] analyzer. Both in patients with active SLE without nephritis and in patients with LN, serum levels of IL-1Ra (p<0.001) were significantly higher compared with those in the controls. IL-1Ra was significantly higher in patients with active LN than in patients with inactive LN (p = 0.028). The use of methylprednisolone was significantly higher in the active LN group compared with the inactive LN group (p = 0.013). SLE patients with higher IL-1Ra are at lower risk for developing nephritis. The higher doses of glucocorticosteroids needed in active LN could be due to steroid resistance and IL-1Ra polymorphism. Measurement of IL-1Ra levels in SLE patients could help to predict future renal involvement.
3rd Department of Internal Medicine, Division of Clinical Immunology, Medical and Health Science Center of University of Debrecen, Debrecen, Hungary.
Boglarka
B
Brugos
Emese
E
Kiss
Csaba
C
Dul
Wolfgang
W
Gubisch
Gyula
G
Szegedi
Sandor
S
Sipka
Margit
M
Zeher
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D008181:Lupus Nephritis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011507:Proteinuria / Q000652:urine; D012720:Severity of Illness Index; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000097:blood
D015415:Biomarkers; D053590:Interleukin 1 Receptor Antagonist Protein; D053482:beta 2-Glycoprotein I; D016572:Cyclosporine; D003520:Cyclophosphamide; D002097:C-Reactive Protein; D003404:Creatinine; D008775:Methylprednisolone