Bio molecular considerations in major depression and ischemic cardiovascular disease.
In our study we have evaluated the theme of the platelet fatty acid composition in subjects with a clinical diagnosis of Major Depression (MD), in subjects with a clinical diagnosis of Ischemic Heart Disease (IHD) according to the coronary angiography and in control subjects. We have analyzed all the groups without taking in account therapies, gender and age. As far as we know, the platelet fatty acid composition has never been analyzed before, in MD. The results obtained with the Self Organizing Map (SOM) show the evidence of three fatty acids, Arachidonic Acid (AA), Linoleic Acid (LA), and Palmitic Acid (PA) in a peculiar position with respect to the biochemical characterization of MD and three fatty acids, Arachidonic Acid (AA), Linoleic Acid (LA) and Oleic Acid (OA) in a peculiar position with respect to the biochemical characterization of the IHD. Bio molecular considerations are made about the possibility of controlling positive changes in platelet viscosity, in both pathologies.
Cocchi
Massimo
M
Faculty of Veterinary Medicine, University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell'Emilia, Bologna, Italy. massimo.cocchi@unibo.it
Tonello
Lucio
L
D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000032:analysis; D001792:Blood Platelets / Q000737:chemistry* / Q000166:cytology; D002318:Cardiovascular Diseases / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood*; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000032:analysis; D008297:Male; D021962:Membrane Microdomains / Q000737:chemistry; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D019301:Oleic Acid / Q000032:analysis; D019308:Palmitic Acid / Q000032:analysis; D013234:Stem Cells / Q000502:physiology; D055815:Young Adult
D005227:Fatty Acids; D008041:Linoleic Acids; D016718:Arachidonic Acid; D019301:Oleic Acid; D019308:Palmitic Acid