Screening-detected and symptomatic untreated celiac children show similar gut microflora-associated characteristics.
OBJECTIVE
The aim of this study was to investigate the metabolic function of intestinal microflora in children with screening-detected celiac disease (CD) to see if there is an aberrant gut flora in screening-detected CD similar to symptomatic CD and contrary to healthy controls.


METHODS
As part of a Swedish multicenter screening for CD, 912 12-year-old children were screened with serum anti-human tissue transglutaminase-IgA. Small bowel biopsy specimens from children with positive serology revealed 17 individuals with CD. The functional status of the intestinal microflora was evaluated by gas-liquid chromatography of short chain fatty acids (SCFAs) in fecal samples. Our previously published findings in children with symptomatic CD and healthy controls were used as comparison.


RESULTS
The children with screening-detected CD had a similar fecal SCFA profile to children with symptomatic CD, but differed significantly from that in healthy children.


CONCLUSIONS
This is the first study on SCFA patterns in fecal samples from children with screening-detected CD. The similarity of the fecal SCFA profile in screening-detected and symptomatic CD indicates common pathogenic mechanisms. This could open the way for new therapeutic or prophylactic measures based on novel biological principles.
Tjellström
Bo
B
Department of Microbiology, Tumor and Cell Biology, Karolinska Institut, Stockholm, Sweden. bo.tjellstrom@ki.se
Stenhammar
Lars
L
Högberg
Lotta
L
Fälth-Magnusson
Karin
K
Magnusson
Karl-Eric
KE
Midtvedt
Tore
T
Sundqvist
Tommy
T
Norin
Elisabeth
E
D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology*; D002648:Child; D005232:Fatty Acids, Volatile / Q000032:analysis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D008403:Mass Screening; D011503:Transglutaminases / Q000097:blood*
D015415:Biomarkers; D005232:Fatty Acids, Volatile; D007070:Immunoglobulin A; D011503:Transglutaminases