[Effect of side-effects and complications caused by atypical neuroleptics on the effectiveness of therapy in patients with schizophrenia].
434 patients were treated with clozapine, risperidone, olanzapine, quetiapine or typical neuroleptics. Main types of undesirable effects (side-effects and complications) that affected the effectiveness of treatment were singled out. It has been shown that the reduction of effectiveness may lead to the revision of treatment plan on life-saving indications or due to ethical considerations, the maintenance of therapeutic collaboration or the negative attitude of relatives to treatment. The data obtained suggest a different effect of side-effects on the effectiveness of treatment with atypical and typical antipsychotic drugs.
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Danilov
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use; D003987:Dibenzothiazepines / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000077152:Olanzapine; D000069348:Quetiapine Fumarate; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine