Episodic cerebellar dysfunction in a bichon frise: a canine case of episodic ataxia?
A four-year-old neutered male bichon frise was presented for the evaluation of chronic, progressive yet episodic neurological dysfunction that was predominantly cerebellar in nature. Diagnostic testing including haematology, serum chemistry, magnetic resonance imaging, cerebrospinal fluid analysis and urine organic acid screening was normal. Trial therapies with phenobarbital, prednisone and acetazolamide were unsuccessful. Treatment with 4-aminopyridine led to complete resolution of the signs.
Hopkins
A L
AL
North Florida Neurology, 280 Corporate Way, Orange Park, FL 32073, USA.
Clarke
J
J
D015761:4-Aminopyridine / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D008279:Magnetic Resonance Imaging; D008297:Male; D020754:Spinocerebellar Ataxias / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
D000927:Anticonvulsants; D015761:4-Aminopyridine