Non-atherosclerotic coronary artery disease associated with sudden cardiac death.
BACKGROUND
The concept of non-atherosclerotic coronary artery pathology in sudden cardiac death (SCD) has not been given the attention it deserves.


OBJECTIVE
To determine the incidence of non-atherosclerotic coronary artery pathology in SCD and raise awareness among cardiologists and pathologists alike.


METHODS
Retrospective non-case-controlled analysis. Setting Cardiac pathology centre at the National Heart and Lung Institute and Royal Brompton Hospital.


METHODS
Between 1994 and 2008, the hearts of 1647 people undergoing SCD were referred for pathological assessment to ascertain the precise aetiology of SCD.


RESULTS
Fifty (3.0%) of the 1647 cases of SCD were associated with non-atherosclerotic coronary pathology (31 male subjects (62%) and 19 female subjects (38%, age range (8 weeks-71 years)). Twenty four of the 50 cases had anomalous coronary arteries (48%); eight cases had coronary artery dissection (16%); six cases had coronary artery vasculitis (12%); six cases had coronary artery spasm (12%); three cases had idiopathic arterial calcification of infancy (6%); two cases had fibromuscular dysplasia (4%) and one case had a benign tumour occluding the left coronary ostium (2%). Only 20 of the 50 patients (40%) were documented to have experienced cardiac symptoms such as syncope, chest pain on exertion or breathlessness before their SCD. Twelve of the patients (24%) died during or immediately after physical exertion.


CONCLUSIONS
Non-atherosclerotic coronary disease is associated with sudden death in all age groups, particularly younger, male patients. Cardiologists need to be aware of these entities and investigate any patient who has cardiac symptoms especially with exertion.
Imperial College London, UK.
Sharleen F
SF
Hill
Mary N
MN
Sheppard
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000784:Aortic Dissection / Q000150:complications / Q000175:diagnosis; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000150:complications / Q000175:diagnosis; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis; D003327:Coronary Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D003329:Coronary Vasospasm / Q000150:complications / Q000175:diagnosis; D003330:Coronary Vessel Anomalies / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis; D055815:Young Adult