Invasive aspergillosis osteomyelitis in children--a case report and review of the literature.
Immunocompromised patients are at high risk of secondary infection associated with high morbidity. In children these complications include fungal osteomyelitis due to continuous infiltration or hematogenous spread. The case of a 4-year-old boy is presented who developed lumbalgia and thigh pain during ongoing chemotherapy for acute lymphatic leukemia. MRI revealed infarct-like lesions in the femur and L5 vertebra, which were biopsied. The histologic diagnosis was consistent with angioinvasive aspergillosis. A multifocal osseous presentation has rarely been described in children and an overview of the literature is presented. Invasive aspergillosis is a rare complication to be considered in children with MRI-detected bony lesions of infarct-like appearance.
Winterstein
Anton R
AR
Department of Radiology, Klinikum Augsburg, Stenglinstr. 2, Augsburg, Germany.
Bohndorf
Klaus
K
Vollert
Kurt
K
Wagner
Theodor
T
Gnekow
Astrid
A
Roemer
Frank W
FW
D001228:Aspergillosis; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005269:Femur / Q000000981:diagnostic imaging*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology; D010146:Pain; D010198:Pancytopenia / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D011859:Radiography; D014463:Ultrasonography