[Development of heart failure in the course of coronary artery disease--the role of genetic factors].
The number of patients suffering from heart failure is constantly increasing. One of its main causes is coronary artery disease, especially myocardial infarction. Progression of heart failure depends both on the extent of ischaemic injury and the course of subsequent adaptive processes. Genetic methods may help to find individuals at high risk of developing heart failure. There are multiple genes influencing circulatory system, some of their alleles may potentially affect progression of the disease. Among the most promising targets are genes of the renin-angiotensin-aldosterone system: insertion/deletion (L/D) polymorphism of angiotensin converting enzyme gene, polymorphisms of angiotensinogen, angiotensin receptors (AT1 and AT2) and aldosterone syntase genes. Other genetic factors, which may affect are different gene variants of adrenergic receptors (beta1, beta2, alpha2C), AMP deaminase-1, endothelin-1, endothelial nitric oxide syntase, precursors of natriuretic peptides and inflammatory factors (TNF-alpha, IL-6, MCP-1, TGF, MMP-2). Furthermore, the response to drugs may depend on genetic background, that is why pharmacogenetics creates new possibilities to tailor the best therapy for each patients with heart failure. Therefore research in the field of genetic factors affecting the development of heart failure has not only scientific, but also practical value.
Klinika Kardiologii, Akademia Medyczna, Białystok.
Anna
A
Kozieradzka
Karol
K
Kamiński
Włodzimierz J
WJ
Musiał
D003327:Coronary Disease / Q000150:complications*; D018450:Disease Progression; D006333:Heart Failure / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications; D045265:Natriuretic Peptides / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D057285:Precision Medicine / Q000379:methods; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics*
D045265:Natriuretic Peptides; D018342:Receptors, Adrenergic, beta-1