Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma.
OBJECTIVE
To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals.


METHODS
24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device.


RESULTS
Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05).


CONCLUSIONS
Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.
Department of Ophthalmology, University of Campinas, Campinas, Rua Bahia 1087, São Paulo, Brazil. vp.costa@uol.com.br
Vital P
VP
Costa
Jesus
J
Jimenez-Roman
Felix Gil
FG
Carrasco
Alvaro
A
Lupinacci
Alon
A
Harris
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D002940:Circadian Rhythm; D005123:Eye / Q000098:blood supply*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies