Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.
Da-Cheng-Qi decoction (DCQD) is a purgative compound prescription used in China and East Asia. In this paper, pharmacokinetic differences of six major active components (rhein, emodin, aloe-emodin, magnolol, naringenin and hesperetin) between DCQD and its three constitutional herbal medicines, i.e., Radix et Rhizoma Rhei, Cortex Magnoliae officinalis and Fructus Aurantii Immaturus were investigated in rats after oral administration. Plasma samples were analyzed for the quantification of the six active components using validated LC-MS/MS methods. Unpaired Student's t-test was used for statistical comparison. Significant differences (p < 0.05) in the main pharmacokinetic parameters for rhein, emodin, aloeemodin, magnolol, naringenin and hesperetin were found between DCQD and the decoction of its constitutional single herbal medicines, which demonstrated the presence of drug-drug interactions between these constitutional raw materials of DCQD occurring either in the procedure of decoction or during ADME process.
Key Laboratory ofDrug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, 210009, China.
Fengguo
F
Xu
Ying
Y
Liu
Haijuan
H
Dong
Rui
R
Song
Zunjian
Z
Zhang
D000818:Animals; D000880:Anthraquinones / Q000032:analysis / Q000493:pharmacokinetics; D019540:Area Under Curve; D001713:Biphenyl Compounds / Q000032:analysis / Q000493:pharmacokinetics; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D004642:Emodin / Q000032:analysis / Q000493:pharmacokinetics; D005260:Female; D044950:Flavanones / Q000032:analysis / Q000493:pharmacokinetics; D006569:Hesperidin / Q000032:analysis / Q000493:pharmacokinetics; D017705:Lignans / Q000032:analysis / Q000493:pharmacokinetics; D008297:Male; D010936:Plant Extracts; D051381:Rats; D017207:Rats, Sprague-Dawley; D053719:Tandem Mass Spectrometry
D000880:Anthraquinones; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D017705:Lignans; D010936:Plant Extracts; C477169:dachengqi decoction; C005498:magnolol; C518327:aloe emodin; D006569:Hesperidin; C005273:naringenin; D004642:Emodin; C013015:hesperetin; C020491:rhein