Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population.
In the present work we genotyped three single-nucleotide polymorphisms (SNPs) (rs7301328, rs1805247, and rs1805502) of the GRIN2B gene in a set of 480 unrelated bipolar disorder patients and 480 unrelated genetically matched normal controls in Chinese Han population by either allelic-specific multiplex ligation-detection reaction (AMLR) technology or direct sequencing. Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.
Bio-X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong, University, PR China.
Qian
Q
Zhao
Ronglin
R
Che
Zhao
Z
Zhang
Peng
P
Wang
Jun
J
Li
You
Y
Li
Ke
K
Huang
Wei
W
Tang
Guoyin
G
Feng
Klaus
K
Lindpaintner
Lin
L
He
Yongyong
Y
Shi
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate