Ethicolegal aspects of cancer genetics.
In the wake of efficacious preventive interventions based on hereditary cancer risk assessment, a number of ethical and legal challenges have emerged. These include issues such as appropriate testing of children and embryos, the "duty to warn" relatives about familial risk, reproductive genetic testing, the risk of genetic discrimination, and equitable access to testing. These and other issues will be discussed within the framework of a bioethical model, with reference to recent case law.
Offit
Kenneth
K
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. offitk@mskcc.org
Thom
Peter
P
D001675:Bioethics; D002648:Child; D005260:Female; D005817:Genetic Counseling; D005820:Genetic Testing / Q000331:legislation & jurisprudence; D005823:Genetics / Q000331:legislation & jurisprudence*; D015894:Genome, Human; D023281:Genomics / Q000331:legislation & jurisprudence* / Q000458:organization & administration; D006801:Humans; D008297:Male; D011247:Pregnancy; D011287:Prejudice; D011296:Prenatal Diagnosis; D018570:Risk Assessment; D014481:United States