Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms.
Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC). Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of seizures in mice and subsequent changes in brain histamine levels were estimated. A significant inhibition of ES-induced seizures was seen after the simultaneous use of clobenpropit and pyridoxine. No significant effects were evident on the brain histamine levels following this combination. The combination of clobenpropit with pyridoxine appears to exhibit beneficial pharmacodynamic interaction for the prevention of ES-induced seizures, which might not be mediated by the histaminergic mechanisms.
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
P
P
Uma Devi
A
A
Manocha
R
R
Khanam
D
D
Vohora
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D004597:Electroshock / Q000009:adverse effects*; D005260:Female; D006632:Histamine / Q000378:metabolism; D054828:Histamine H3 Antagonists / Q000627:therapeutic use*; D006640:Histidine Decarboxylase / Q000378:metabolism*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011736:Pyridoxine / Q000627:therapeutic use*; D012640:Seizures / Q000517:prevention & control*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000927:Anticonvulsants; D054828:Histamine H3 Antagonists; D007093:Imidazoles; D006632:Histamine; D006640:Histidine Decarboxylase; D013890:Thiourea; D011736:Pyridoxine; C086108:clobenpropit