Brief report: Sensorimotor gating in idiopathic autism and autism associated with fragile X syndrome.
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute, University of California-Davis, Medical Center, 2825 50th street, Sacramento, CA 95817, USA.
Jennifer
J
Yuhas
Lisa
L
Cordeiro
Flora
F
Tassone
Elizabeth
E
Ballinger
Andrea
A
Schneider
James M
JM
Long
Edward M
EM
Ornitz
David
D
Hessl
D000293:Adolescent; D000704:Analysis of Variance; D001321:Autistic Disorder / Q000150:complications / Q000503:physiopathology*; D002648:Child; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology; D013216:Reflex, Startle / Q000502:physiology; D055139:Sensory Gating / Q000502:physiology; D018709:Statistics, Nonparametric; D055815:Young Adult