The clinical use of type 1 interferon in gynecology.
Interferons were initially described in terms of their role in blocking viral replication. They are important cytokines that act on various aspects of cell physiology. Importantly, they can affect cell proliferation or induce the differentiation of neoplastic cells. The exact way in which the interferon complex (IFN) acts on tumours is still unknown, although their use in clinical practice has been widely recommended, especially with tumours that are resistant to conventional treatments, or in situations where surgical removal might lead to a loss of organ function. IFN can be employed as a treatment for various chronic diseases, including tumours. Indeed interferon cytokines are the therapy of choice in certain situations. However, one of the difficulties yet to be overcome is the need for frequent administrations of the drug. We believe that the development of new formulations is needed to match the demand for its use in oncology treatment.
Ramos
M C
MC
General Pathology, Oncological Research Institute (Instituto de Pesquisa em Oncologia/IPON), Federal University of the Triângulo Mineiro, Brazil.
Mardegan
M C
MC
Tirone
N R
NR
Michelin
M A
MA
Murta
E F C
EF
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology; D007370:Interferon Type I / Q000627:therapeutic use*; D015398:Signal Transduction / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000276:immunology
D007370:Interferon Type I