Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients.
BACKGROUND
Mean platelet volume (MPV) is an indicator of platelet activation which is a central process in the pathophysiology of coronary heart disease (CHD). The aim of the study was twofold; first to determine whether MPV values is increased in patients with DM, and secondly to evaluate the relation between diabetic complications and MPV.


METHODS
The study population included 258 patients divided into two groups. Group A composed of 158 type 2 diabetic patients with coexistent coronary artery disease (stenotic lesions of 50%) (78 women, 80 men; mean age 53.9_10.8; mean diabetes duration 13.1_6.0). One hundred subjects (48 women, 52 men; mean age 53.9_11) without type 2 diabetes with normal coronary angiographies were taken as the control group (group B). To evaluate the extension of CHD, Gensini scoring system was used.


RESULTS
The MPV was significantly different in the patient group compared to the controls (9.79 +/- 1.5 fl vs 8.3 +/- 0.9 fl, P<0.001). The existence of CHD was associated with MPV with odds ratio (95% CI) of 2.31 (1.55-4.42, p50.001).


CONCLUSIONS
We have found that diabetic patients with coronary heart disease have significantly higher MPV values compared to control subjects without diabetes and with angiographically normal coronary arteries.
Gazi University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey. yusuftavil@gmail.com
Yusuf
Y
Tavil
Nihat
N
Sen
Hüseyin
H
Yazici
Murat
M
Turfan
Fatma
F
Hizal
Atiye
A
Cengel
Adnan
A
Abaci
D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
D015415:Biomarkers