[Meiotic inactivation of sex chromosomes in mammals].
During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X chromosome preserve inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which his observed in mammalian females at early embryogenetic stages.
E A
EA
Vas'kova
S V
SV
Pavlova
A I
AI
Shevchenko
S M
SM
Zakinian
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D033481:Chromosomes, Mammalian / Q000235:genetics / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000196:embryology; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D018392:Genomic Imprinting / Q000502:physiology; D008297:Male; D008322:Mammals / Q000235:genetics / Q000378:metabolism*; D008540:Meiosis / Q000502:physiology*; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism*; D049951:X Chromosome Inactivation / Q000502:physiology*; D014998:Y Chromosome / Q000235:genetics / Q000378:metabolism*; D015053:Zygote / Q000378:metabolism
D002843:Chromatin