[Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury induced by isoproterenol in rats].
OBJECTIVE
To investigate the protective effect of total flavonoid of Herba Pyrolae (TFHP) on acute myocardial ischemic injury induced by isoproterenol in rats and the primary mechanisms.


METHODS
Acute myocardial ischemic models were established by i. s. of isoproterenol. ECG of the rats were recorded, activities of creatine phosphokinase (CK), lactate dehydrogenase (LDH) and the superoxide dismutase (SOD), and the levels of malondialdehyde (MDA), NO and FFA in rat serum were determined, heart index were measured and histopathological changes of myocardium were observed.


RESULTS
In comparison with model group, TFHP raised the height of T wave, reduced CK, LDH activities and FFA levels in serum, decreased heart index and relieved myocardial ischemic injury. The primary study of its mechanism showed that TFHP decreased MDA level, increased SOD activity and NO levels in the rat serum.


CONCLUSIONS
TFHP has protective effect on acute myocardial ischemic injury possibly via antioxidation and increasing the release and production of NO.
Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Pei-Pei
PP
Lu
Jun-Tian
JT
Liu
Na
N
Liu
Li
L
Xu
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004562:Electrocardiography; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D017202:Myocardial Ischemia / Q000097:blood / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000097:blood; D031828:Pyrola / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009569:Nitric Oxide; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D007545:Isoproterenol