The effect of hydrolysis degree on the properties of antibacterial polymeric films based on poly(vinyl alcohol) and zinc sulphate for biomedical applications.
Fully and partially hydrolyzed poly(vinyl alcohol) (PVA) was modified with zinc sulphate in the concentration range from 0 to 9 wt% of recalculated zinc content using the solvent cast technique. The resulting polymeric films were characterized by optical microscopy, stress-strain analysis, differential scanning calorimetry and Fourier transform infrared spectroscopy (FT-IR-ATR). In addition, agar diffusion test and dilution and spread plate technique were used for determination of antibacterial properties of the films against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacterial strains. A mathematical model was applied on the measured data and parameters characterizing the antibacterial efficiency of the material were calculated and discussed. The results revealed that the PVA hydrolysis degree can play an important role in all studied properties, including antibacterial activity of the all PVA-based materials.
Sedlarik
Vladimir
V
Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, 76272 Zlin, Czech Republic. sedlarik@ft.utb.cz
Galya
Tsermaa
T
Sedlarikova
Jana
J
Valasek
Pavel
P
Saha
Petr
P
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D004926:Escherichia coli / Q000187:drug effects; D006868:Hydrolysis; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D019287:Zinc Sulfate / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011108:Polymers; D019287:Zinc Sulfate; D011142:Polyvinyl Alcohol