Comparative effects of pyrolytic products of fiber reinforced plastic and wood shavings on the respiratory variables in mice.
Comparative inhalation toxicity studies of pyrolytic products (smoke) from synthetic polymer, fiberglass reinforced plastic (FRP) and teak wood shavings were carried out in male Swiss albino mice. The breathing pattern and the respiratory variables were monitored using a computer program that recognizes the modifications of the respiratory pattern. Exposure to the smoke from both the polymers caused a concentration dependent decrease in normal breathing and an increase in sensory irritation measure. The acute lethal concentration 50 values for a 15 min static inhalation exposure to the smoke from FRP and teak wood shavings were found to be > 200.00 and 62.99 g/m(3), respectively. Hence the inhalation toxicity of smoke from FRP sample on a mass basis is approximately one-third that of the smoke from teak wood. The concentration of smoke causing 50% respiratory depression of the exposed animals were found to be 6.877 and 0.106 g/m(3) for FRP and teak wood samples, respectively. Thus the sensory irritancy of the smoke from FRP sample is approximately 65 times lesser than the smoke from teak wood. The higher sensory irritancy potential of wood smoke as compared to FRP smoke may be caused by a greater number of submicron particles (size range of 2 micron and less) and greater percentage of gases present in wood smoke as compared to FRP smoke. Thus in case of accidental fires, synthetic polymers like FRP may be a safer choice for structural parts and interiors than the natural wood.
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, India.
Pravin
P
Kumar
Utsab
U
Deb
Anshoo
A
Gautam
R
R
Vijayaraghavan
Debdatta
D
Ratna
B C
BC
Chakraborty
D000818:Animals; D005390:Fires; D005898:Glass / Q000737:chemistry; D006358:Hot Temperature; D019570:Inhalation Exposure; D008136:Longevity / Q000187:drug effects; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051379:Mice; D010969:Plastics / Q000633:toxicity*; D012129:Respiratory Function Tests; D012906:Smoke / Q000009:adverse effects*; D015208:Smoke Inhalation Injury / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D023382:Toxicity Tests, Acute; D014934:Wood
D010969:Plastics; D012906:Smoke; C009753:fiberglass