Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study.
BACKGROUND
Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer.


METHODS
Subjects were from the Västerbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15 years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression.


RESULTS
No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee ≥4 versus <1 occasions/day was associated with a reduced risk (HR = 0.52, CI = 0.30-0.88, p (trend) = 0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HR(premenopausal) = 1.69, CI = 0.96-2.98, p (trend) = 0.015, HR(postmenopausal) = 0.60, CI = 0.39-0.93, p (trend) = 0.006) and filtered coffee (HR(premenopausal) = 1.76, CI = 1.04-3.00, p (trend) = 0.045, HR(postmenopausal) = 0.52, CI = 0.30-0.88, p (trend) = 0.045). Boiled coffee was positively associated with the risk of respiratory tract cancer (HR = 1.81, CI = 1.06-3.08, p (trend) = 0.084), a finding limited to men. Main results for less common cancer types included total coffee in renal cell cancer (HR = 0.30, CI = 0.11-0.79, p (trend) = 0.009) and boiled coffee in pancreas cancer (HR = 2.51 CI = 1.15-5.50, p (trend) = 0.006).


CONCLUSIONS
These findings demonstrate, for the first time, the potential relevance of brewing method in investigations of coffee consumption and cancer risk, but they must be confirmed in future studies.
Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden. lena.nilsson@nutrires.umu.se
Lena Maria
LM
Nilsson
Ingegerd
I
Johansson
Per
P
Lenner
Bernt
B
Lindahl
Bethany
B
Van Guelpen
D003069:Coffee; D015331:Cohort Studies; D016001:Confidence Intervals; D003296:Cooking; D004326:Drinking; D005260:Female; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D011446:Prospective Studies; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
D003069:Coffee