HIV-1 assembly at the plasma membrane.
HIV-1 particle assembly takes place at the plasma membrane, which likely enhances release of extracellular virions and spread to next target cells. Recent work by our lab and others started to reveal a molecular mechanism by which HIV ensures to make the plasma membrane as a primary site of virus assembly.
Ono
Akira
A
Department of Microbiology and Immunology, University of Michigan Medical School, 5736 Medical Science Building II, 1150 W Medical Center Drive, Ann Arbor, MI 48109-0620, United States. akiraono@umich.edu
D002462:Cell Membrane / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D019065:Virus Assembly; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism
D019269:Phosphatidylinositol 4,5-Diphosphate; D054301:gag Gene Products, Human Immunodeficiency Virus