Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism.
Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.
Kaufman
Randal J
RJ
Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA. kaufmanr@umich.edu
Cao
Siyan
S
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D004722:Endoribonucleases / Q000502:physiology*; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D008565:Membrane Proteins / Q000502:physiology*; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D000071701:Regulatory Factor X Transcription Factors; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology*; D056811:Unfolded Protein Response; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human; C403982:ERN2 protein, human; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases