Synthesis and microbial studies of (4-oxo-thiazolidinyl) sulfonamides bearing quinazolin-4(3H)ones.
2-[(2,6-Dichlorophenyl)amino]phenylacetic acid (A) on reaction with thionyl chloride gave corresponding acid chloride (B). A series of (4-oxo-thiazolidinyl)sulfonamides of quinazolin-4(3H)ones (4a-l) were prepared from Schiff bases (3a-l) of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[(4-aminophenyl)sulfonamido-1-yl]quinazolin-4(3H)one (D) and substituted aromatic aldehyde. Newly synthesized compounds have been examined on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectra. Antibacterial activity (minimum inhibitory concentration - MIC) against Gram-positive (S. aureus & S. pyogeneus) and Gram-negative (P. aeruginosa and E. coli) bacteria, as well as antifungal acivities (MIC) against C. albicans, A. niger and A. clavatus were determined by broth dilution method. Some of the compounds were endowed with a remarkable antibacterial as well as antifungal acivities.
Patel
Navin B
NB
Department of Chemistry, Veer Narmad South Gujarat University, Surat-395 007, India. drnavin@satyam.net.in
Patel
Virendra N
VN
Patel
Hemant R
HR
Shaikh
Faiyaz M
FM
Patel
Jaymin C
JC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D015195:Drug Design; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D052999:Quinazolinones; D012545:Schiff Bases; D013449:Sulfonamides; D013844:Thiazoles