Rapid progression of aortic regurgitation with thoracic aortic aneurysm due to Takayasu arteritis associated with ulcerative colitis.
A 25-year-old woman with ulcerative colitis developed heart failure due to severe aortic regurgitation. Although chest X-ray 18 months previously showed a normal cardiac shadow, thoracic aortic aneurysm progressed due to Takayasu arteritis. Aortic valve and ascending aorta replacement were performed successfully, but re-valve replacement for severe aortic regurgitation due to prosthetic valve detachment and aortic root replacement for valsalva sinus rupture were required. Human leukocyte antigen analysis showed B35 and B52, the typical haplotype in cases with coexistence of both diseases and associated sustained inflammation. Close observation and early aortic root replacement were needed in this case.
Department of Cardiology, National Hospital Organization, Kagoshima Medical Center, Kagoshima, Japan. k-kashima@kagomc2.hosp.go.jp
Katsuro
K
Kashima
Daisuke
D
Kawasaki
Goichi
G
Yotsumoto
Shinsaku
S
Hatake
Erika
E
Yamashita
Shinya
S
Nagayoshi
Yusuke
Y
Yoshishige
Kazuyuki
K
Tanoue
Shinjirou
S
Nagano
Hideki
H
Tanaka
Norihito
N
Nuruki
Masahiro
M
Sonoda
D000328:Adult; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis / Q000209:etiology*; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D006801:Humans; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis; D013997:Time Factors