Target-selective GABAergic control of entorhinal cortex output.
The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.
Varga
Csaba
C
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California, USA. cvarga@uci.edu
Lee
Soo Yeun
SY
Soltesz
Ivan
I
D000818:Animals; D064026:Calbindins; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D018728:Entorhinal Cortex / Q000166:cytology / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism*; D056347:Neuroanatomical Tract-Tracing Techniques; D009474:Neurons / Q000145:classification / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*; D000091042:Reelin Protein; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D064026:Calbindins; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D043884:Receptor, Cannabinoid, CB1; D000091042:Reelin Protein; D064030:S100 Calcium Binding Protein G; D005680:gamma-Aminobutyric Acid; D012697:Serine Endopeptidases