Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4.
The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC(50) < 15 microM).
Sandy
Moriah
M
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.
Han
Andrew
A
Blunt
John
J
Munro
Murray
M
Haygood
Margo
M
Butler
Alison
A
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001120:Arginine / Q000032:analysis; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012694:Serine / Q000032:analysis; D017262:Siderophores / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014733:Vibrio / Q000737:chemistry*
D000970:Antineoplastic Agents; D010455:Peptides; D017262:Siderophores; C550798:divanchrobactin; C550797:trivanchrobactin; C529766:vanchrobactin; D012694:Serine; C049469:anguibactin; D001120:Arginine