Nonhuman primate models of human immunology.
Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system.
Messaoudi
Ilhem
I
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA. messaoud@ohsu.edu
Estep
Ryan
R
Robinson
Bridget
B
Wong
Scott W
SW
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008253:Macaca mulatta / Q000276:immunology*; D023421:Models, Animal; D018448:Models, Immunological