Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.
Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT(1B) and 5-HT(1D) receptors in macaques and rats. In the inner ear, 5-HT(1B) and 5-HT(1D) receptor immunopositivity was associated with endothelial cells of the vestibular ganglion, spiral ganglion, vestibulocochlear nerve, spiral ligament and stria vascularis. It was noteworthy that 5-HT(1B) and 5-HT(1D) receptors are expressed in parallel sites in peripheral vestibular and trigeminal systems, which may be a factor underlying the efficacy of triptans in treating migraine and migrainous vertigo. Because the vestibular ganglion and trigeminal ganglion are both within the subarachnoid space, an interaction between 5-HT(1B) and TRPV1 receptors on blood vessel and ganglion cells may also contribute to the vasospasm and the comorbid headache, dizziness, nausea and vomiting that accompany subarachnoid hemorrhage.
Department of Otolaryngology, School of Medicine, Gyeongsang National University, and University Hospital Jinju, Korea.
Seong-Ki
SK
Ahn
Carey D
CD
Balaban
D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism; D003627:Data Interpretation, Statistical; D007758:Ear, Inner / Q000378:metabolism*; D007150:Immunohistochemistry; D008253:Macaca mulatta; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D044346:Receptor, Serotonin, 5-HT1D / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism; D014363:Tryptamines / Q000494:pharmacology
D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D014363:Tryptamines