New anti-inflammatory 4-hydroxyisoflavans from Solanum lyratum.
Three new 4-hydroxyisoflavans, named lyratin A (1), lyratin B (2) and lyratin C (3), along with a known compound, 4,7,2'trihydroxy-4'-methoxyisoflavan (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by means of detailed physical data analyses. In vitro, four compounds showed anti-inflammatory activities with inhibitory ratios of release of beta-glucuronidase from polymorphonuclear leukocytes of rats in the range of 30.3-38.6% at 10 microM.
School of Pharmaceutical Science, Yantai University.
De-Wu
DW
Zhang
Gui-Hai
GH
Li
Qun-Ying
QY
Yu
Sheng-Jun
SJ
Dai
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D032322:Solanum / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D007529:Isoflavones