A new method of screening human papillomavirus genotypes and clinical validation.
Human papillomavirus (HPV) infection is a necessary factor in the development of cervical cancer. A new HPV screening method, "Human Papillomavirus Genotyping (HPG)", was developed to detect 29 HPV genotypes distribution in China. The utility of HPG was compared to Hybrid Capture 2 High-Risk HPV DNA test (HC2), and it was determined that the HPG test had been proven to be a more credible and sensitive screening HPV method than the HC2 test. HPV16, HPV 52, HPV 56, and HPV 58 were the four most common HPV genotypes in women who have suffered chronic cervicitis or abnormal vaginal bleeding in China. HPV 16 (28.57%) and 18 (17.86%) were more likely to infect multiple HPV genotypes than other HPV genotypes. Age group more than 50 years had a higher risk than other age groups.
Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, China.
Peng-jun
PJ
Zhang
Xin-xin
XX
Deng
Gan-rong
GR
Bai
Shu-fang
SF
Jiang
Cui-lian
CL
Lu
Xue-ji
XJ
Zhang
Hong-li
HL
Tong
Ye-nong
YN
Du
Hua-yang
HY
Fu
Peng
P
Huang
Ying
Y
Ma
Ya-ping
YP
Tian
D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D001483:Base Sequence; D002681:China; D017931:DNA Primers; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction
D017931:DNA Primers; D004279:DNA, Viral