Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.
The synthesis and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated, and some of these derivatives showed better in vitro antibacterial activity than existing drugs, including penicillin, ciprofloxacin, vancomycin, and linezolid.
Shi
Wei
W
Department of Chemistry, East China Normal University, Shanghai, China.
Duan
Yuejiao
Y
Qian
Yu
Y
Li
Ming
M
Yang
Liping
L
Hu
Wenhao
W
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D015195:Drug Design; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000588:Amines; D000900:Anti-Bacterial Agents; D011758:Pyrroles; D000581:Amidohydrolases; C084507:peptide deformylase