Intranasal administration of nerve growth factor produces antidepressant-like effects in animals.
Many works showed that nerve growth factor (NGF) injected into the brain of animal model emerges potential antidepressant effects. However, this route of administration significantly restricts the application of NGF clinically. Here, we reported that intranasal NGF could provide an alternative to intraventricular injection. The behavioral analysis showed that intranasal administration of NGF reduced the immobility time in forced swimming test (FST) and tail suspension test (TST) in mice. Likewise, intranasal NGF increased the sucrose intake and the locomotor activity in rats after unpredictable chronic mild stress (UCMS). Furthermore, intranasal NGF increased the levels of monoamine neurotransmitters (norepinephrine, dopamine) in the frontal cortex and hippocampus and affected the number of 5-bromodeoxyuridine (BrdU), c-fos and caspase-3 positive neurons in dentate gyrus of hippocampus in rats after UCMS. In summary, intranasal NGF had significant antidepressant effects on animal models of depression and this route of administration may provide a promising way to deliver NGF to brain in a therapeutic perspective.
Shi
Cui-ge
CG
Department of Neurobiology, Capital Medical University, Beijing, China.
Wang
Lu-ming
LM
Wu
Ying
Y
Wang
Peng
P
Gan
Zhu-jun
ZJ
Lin
Kai
K
Jiang
Li-xin
LX
Xu
Zhi-qing
ZQ
Fan
Ming
M
D000281:Administration, Intranasal; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000032:analysis; D001923:Brain Chemistry; D053148:Caspase 3 / Q000378:metabolism; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D020932:Nerve Growth Factor / Q000008:administration & dosage / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009483:Neuropsychological Tests; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological; D013395:Sucrose
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D016760:Proto-Oncogene Proteins c-fos; D013395:Sucrose; D020932:Nerve Growth Factor; D053148:Caspase 3