Pneumoproteins and inflammatory biomarkers in asphalt pavers.
Pneumoproteins, biomarkers of systemic inflammation and endothelial activation were studied across a season in 72 asphalt pavers, 32 asphalt plant operators and 19 asphalt engineers. Smokers had lower concentrations of Clara cell protein (CC-16) and surfactant protein A, but higher concentrations of surfactant protein D, interleukin 6, C-reactive protein, fibrinogen and intercellular adhesion molecule (ICAM)-1 than non-smokers. Smokers reporting wheezing had lower mean CC-16 concentration than smokers not reporting wheezing (5.7 vs 8.6 microg l(-1); p = 0.05). Cholesterol, P-selectin and ICAM-1 were lower in pavers and operators at the end compared with the start of the season. This may be related to increased physical activity during the season.
National Institute of Occupational Health, Oslo, Norway. dag.ellingsen@stami.no
Dag G
DG
Ellingsen
Bente
B
Ulvestad
Lena
L
Andersson
Lars
L
Barregard
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D003252:Construction Materials; D016207:Cytokines / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005340:Fibrinogen; D006801:Humans; D006838:Hydrocarbons; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6; D016014:Linear Models; D008168:Lung / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016273:Occupational Exposure / Q000032:analysis*; D019007:P-Selectin; D011506:Proteins / Q000737:chemistry*; D012129:Respiratory Function Tests; D012140:Respiratory Tract Diseases / Q000453:epidemiology; D012621:Seasons; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry; D011795:Surveys and Questionnaires; D055815:Young Adult
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; D006838:Hydrocarbons; D015850:Interleukin-6; D019007:P-Selectin; D011506:Proteins; C006647:asphalt; D005340:Fibrinogen