Targeting IL-23 in human diseases.
BACKGROUND
IL-23 is one of the most intriguing cytokine for its many immunological functions, which are the basis of its important role in host defense but also of its possible contribution to the pathogenesis of several diseases.


METHODS
The literature and patents about IL-23 pathway and their targeting in therapeutic potential applications. Findings published within the last 5 years receive particular attention.


RESULTS
An overview of the emerging role of IL-23 in physiological and pathological conditions and a review of the different approaches (IL-23 pathway-based) currently used for autoimmune diseases and cancer therapies and the results obtained both in preclinical models and in clinical trials.


CONCLUSIONS
Inhibition/targeting of IL-23 may be a good and novel therapeutic strategy, especially in the treatment of diseases like psoriasis, for which current treatments show more pronounced side effects than those of IL-23-blocking and employed as part of specific patient-tailored therapies in inflammatory bowel diseases.
D'Elios
Mario M
MM
University of Florence, Department of Internal Medicine, Viale Morgagni 85, 50134 Florence, Italy.
Del Prete
Gianfranco
G
Amedei
Amedeo
A
D000818:Animals; D015551:Autoimmunity / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D053759:Interleukin-23 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D011565:Psoriasis / Q000188:drug therapy / Q000503:physiopathology; D018123:Receptors, Interleukin / Q000737:chemistry / Q000502:physiology
D020381:Interleukin-17; D053759:Interleukin-23; D018123:Receptors, Interleukin