[Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder].
OBJECTIVE
To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD).


METHODS
We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed.


RESULTS
No significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0.1004 and P=0.4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022).


CONCLUSIONS
The rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD.
Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, 200030 PR China.
Xiao-hua
XH
Liu
Yi-feng
YF
Xu
Dong-hong
DH
Cui
San-duo
SD
Jiang
Yi-ping
YP
Qian
Shun-ying
SY
Yu
Kai-da
KD
Jiang
D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein