Study of experiment on leaching of bisphenol A from infant books to artificial saliva.
OBJECTIVE
To assess the risk of bisphenol A (BPA) exposure when infants suck or chew infant books, the concentration of BPA leaching from infant books published by Japanese makers to artificial saliva was measured.


METHODS
The concentration of BPA leaching from 10 infant books to 15 ml artificial saliva or water was measured at 37 degrees C for 20 hrs. BPA concentration was measured by high-performance liquid chromatography-electrochemical detection (HPLC-ECD) with solid-phase extraction.


RESULTS
BPA was leached from all books when pieces of them were dipped both into saliva and water for 20 hrs. The highest concentration of BPA leaching from one out of 10 books was 43.4 ng/ml (for 2 hrs) in saliva, which was estimated to be approximately 0.052 mg/kg body weight/day for infants aged 6-10 months.


CONCLUSIONS
As BPA has endocrine-disrupting effects and poses higher risks in infants than in adults, it is desired to reduce BPA use in the printing of infant books from the viewpoint of child health.
Chiba Prefectural Institute of Public Health, Nitona-Cho, Chuoku, Chiba, Japan. j.sjk2@ma.pref.chiba.lg.jp
Junko
J
Sajiki
Ryoko
R
Yanagibori
Yaeko
Y
Kobayashi
D001559:Benzhydryl Compounds; D001877:Books; D002851:Chromatography, High Pressure Liquid; D052244:Endocrine Disruptors / Q000032:analysis; D010636:Phenols / Q000032:analysis; D018570:Risk Assessment; D012464:Saliva, Artificial; D012995:Solubility; D014867:Water; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D012464:Saliva, Artificial; D014867:Water; C006780:bisphenol A; D000098826:Bisphenol A Compounds