Harnessing the antioxidant power with ARE-inducing compounds.
The Nrf2-ARE system is a potential therapeutic target for cancers and neurodegenerative diseases. In this issue, Hur et al. (2010) report the discovery of a novel modifiable Nrf2-ARE activator from the unbiased high throughput screening of a small molecule library.
Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, Center for TARA, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan. makobayash@md.tsukuba.ac.jp
Makoto
M
Kobayashi