Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival.
The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection. To this end we first characterized 32 different mouse strains infected with P. berghei and identified survival as the best trait to discriminate between the strains. We found a locus on chromosome 6 by linking the survival phenotypes of the mouse strains to their genetic variations using genome wide analyses such as haplotype associated mapping and the efficient mixed-model for association. This new locus involved in malaria resistance contains only two genes and confirms the importance of Ppar-gamma in malaria infection.
Bopp
Selina E R
SE
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America. selina@scripps.edu
Ramachandran
Vandana
V
Henson
Kerstin
K
Luzader
Angelina
A
Lindstrom
Merle
M
Spooner
Muriel
M
Steffy
Brian M
BM
Suzuki
Oscar
O
Janse
Chris
C
Waters
Andrew P
AP
Zhou
Yingyao
Y
Wiltshire
Tim
T
Winzeler
Elizabeth A
EA
D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics; D004198:Disease Susceptibility; D056426:Genetic Loci / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D008288:Malaria / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D047495:PPAR gamma / Q000235:genetics*; D010641:Phenotype; D010962:Plasmodium berghei / Q000502:physiology; D016019:Survival Analysis
D047495:PPAR gamma