A metabolic (re-)balancing act.
Cells lacking a functional tuberous sclerosis complex (TSC) heterodimer are sensitized to glucose starvation-induced death. In this issue of Molecular Cell, Choo et al. (2010) report that reducing energy consumption allows these cells to survive on glutamine as an alternative energy source.
Abraham
Robert T
RT
Center for Integrative Biology and Biotherapeutics, Pfizer Biopharmaceuticals, Pearl River, NY 10965, USA. robert.abraham@pfizer.com
Eng
Christina H
CH