When push comes to shove: SWI/SNF uses a nucleosome to get rid of a nucleosome.
A report in this issue of Molecular Cell (Dechassa et al., 2010) provides evidence that a translocating SWI/SNF-nucleosome complex efficiently displaces neighboring nucleosomes in vitro and may account for SWI/SNF-dependent nucleosome eviction in vivo.
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA.
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Jeffrey J
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Hayes