[The synthesis of O-substituted 3-oximes of 6alpha-methyl-16alpha,17alpha-cyclohexanopregn-4-ene-3,20-dione tritium-labeled in 1 and 2 positions].
1,2-Tritium-labeled 3-(O-carboxypropyl)- and 3-(O-carbomethoxypropyl)-oximes of 6alpha-methyl-16alpha,17alpha-cyclohexanopregn-4-ene-3,20-diones were obtained by the homogeneous catalytic hydrogenation of 1,2-dehydroprecursors with gaseous tritium and the subsequent separation of the resulting mixtures by HPLC. The specific radioactivities of 50-55 Ci/mmol were prepared using tris-(triphenylphosphine)-rhodium chloride.
Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 2, Moscow, 123182 Russia. nagaev@img.ras.ru
V P
VP
Shevchenko
I Iu
IIu
Nagaev
I S
IS
Levina
L E
LE
Kulikova
N F
NF
Miasoedov
A V
AV
Kamernitzkiĭ
D002384:Catalysis; D007553:Isotope Labeling; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry; D011282:Pregnenediones / Q000138:chemical synthesis* / Q000737:chemistry; D014316:Tritium
D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D010091:Oximes; D011282:Pregnenediones; C016305:chlorotris(triphenylphosphine)rhodium; D014316:Tritium