Phenolic constituents from Brainea insignis.
Phytochemical investigation on the methanol extract of Brainea insignis led to the isolation of 16 phenolic compounds, including an unusual flavanol coupled with phenylpropyl and shikimic acid units, brainicin (1), and a new flavonol acylglycosides brainoside B (2). The structures of new compounds were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-5 were evaluated for their cytotoxic effects. However, none of the compounds showed significant cytotoxic activity against the HL-60, A549, SMMC-7721, MCF-7, SW480 cell lines (IC(50) > 40 microM).
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
Kou
K
Wang
Ming-Ming
MM
Li
Xuan-Qin
XQ
Chen
Li-Yan
LY
Peng
Xiao
X
Cheng
Yan
Y
Li
Qin-Shi
QS
Zhao
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D029624:Ferns / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D010636:Phenols