Population-based observational study of claudication in older men: the Health in Men Study.
OBJECTIVE
To assess the prevalence of and risk factors for claudication and its association with subsequent cardiovascular events.


METHODS
Observational cohort study of 12 203 Western Australian men aged 65 years and over, recruited from 1996 to 1999, and followed up from 2001 to 2004.


METHODS
Prevalence of claudication and incidence of peripheral arterial disease (PAD); risk factors for claudication and its association with subsequent cardiovascular events.


RESULTS
The prevalence of claudication was 5.3% (638 of 11 970 men). At follow-up, after exclusion of 148 men with claudication at baseline and 76 with missing data at follow-up, the crude average annual incidence of new PAD (claudication or procedure for PAD) was 0.85% (95% CI, 0.72%-0.96%). The risk factors for prevalent claudication and incident PAD were similar, with age, smoking, hypertension, diabetes and history of cardiovascular disease dominating. Of the men with claudication at baseline, nearly half (47.5%; 303 of 638) were not taking aspirin. At follow-up, 42.5% (82 of 193) of the men with incident PAD were not taking aspirin. Claudication at baseline was associated with twice the risk of cardiovascular death (hazard ratio, 2.00; 95% CI, 1.52-2.64). There was a J-shaped relationship between aortic diameter, and both prevalent claudication and subsequent cardiovascular events.


CONCLUSIONS
Among older men, claudication is prevalent and is associated with factors that can still be modified in older age, including smoking, exercise and diet. Relatively few men with claudication or at risk of PAD use aspirin. Claudication is a significant predictor of cardiovascular outcome.
Lakshmanan
Rahul
R
University of Western Australia, Fremantle Hospital, Fremantle, WA, Australia.
Hyde
Zoë
Z
Jamrozik
Konrad
K
Hankey
Graeme J
GJ
Norman
Paul E
PE
D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000401:mortality; D006801:Humans; D015994:Incidence; D007383:Intermittent Claudication / Q000453:epidemiology* / Q000209:etiology; D053208:Kaplan-Meier Estimate; D008297:Male; D016491:Peripheral Vascular Diseases / Q000453:epidemiology / Q000628:therapy; D015995:Prevalence; D016016:Proportional Hazards Models; D012307:Risk Factors; D014904:Western Australia / Q000453:epidemiology