Photosensitive rash in association with porphyrin biosynthesis possibly induced by docetaxel and trastuzumab therapy in a patient with metastatic breast carcinoma.
Docetaxel (Taxotere), an anticancer agent, is known to cause various reactions, including hypersensitivity, oedema, skin toxicity with erythrodysesthesia syndrome, infusion site reactions, alopecia, nail onycholysis, nail pigmentation, photosensitivity, scleroderma and stomatitis. However, of all the reported effects, photosensitivity has only rarely been described in the literature. We experienced a case of cutaneous photosensitivity with aberrations in porphyrin biosynthesis that developed 1 month after the patient received combination chemotherapy consisting of docetaxel and trastuzumab. The eruption resolved with sun avoidance and discontinuation of docetaxel therapy. To our knowledge, this is the first case of a photosensitive reaction with enhanced levels of porphyrins during docetaxel therapy.
Ankara Üniversitesi Tıp Fakültesi, Dermatoloji Anabilim Dalı, İbni Sina Hastanesi, Samanpazari, Ankara 06100, Turkey. nisaakay15@yahoo.com
Bengu Nisa
BN
Akay
Ezgi
E
Unlu
Abdullah
A
Buyukcelik
Aynur
A
Akyol
D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D000077143:Docetaxel; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011166:Porphyrins / Q000096:biosynthesis*; D043823:Taxoids / Q000009:adverse effects; D000068878:Trastuzumab
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D011166:Porphyrins; D043823:Taxoids; D000077143:Docetaxel; D000068878:Trastuzumab