Why Drosophila to study phototransduction?
This review recounts the early history of Drosophila phototransduction genetics, covering the period between approximately 1966 to 1979. Early in this period, the author felt that there was an urgent need for a new approach in phototransduction research. Through inputs from a number of colleagues, he was led to consider isolating Drosophila mutants that are defective in the electroretinogram. Thanks to the efforts of dedicated associates and technical staff, by the end of this period, he was able to accumulate a large number of such mutants. Particularly important in this effort was the use of the mutant assay protocol based on the "prolonged depolarizing afterpotential." This collection of mutants formed the basis of the subsequent intensive investigations of the Drosophila phototransduction cascade by many investigators.
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2054, USA. wpak@purdue.edu
William L
WL
Pak
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D004594:Electrophysiology / Q000266:history*; D004596:Electroretinography / Q000266:history; D049673:History, 20th Century; D023421:Models, Animal; D009154:Mutation; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology*; D014785:Vision, Ocular / Q000235:genetics*