Life-threatening cardiac manifestations of primary antiphospholipid syndrome.
We report a rare case of primary antiphospholipid syndrome (APS) in a 43-year-old man presenting as recurrent acute coronary stent thrombosis and complicated by three myocardial infarctions. As illustrated in this report, in APS patients recurrent life-threatening arterial thrombotic events may occur in spite of recommended anticoagulant therapy. We conclude that the APS should be considered as a potential cause of acute coronary syndrome, particularly in young individuals with a history of recurrent thrombotic events and/or with abnormal coagulation test results. Further studies are needed to determine the best therapeutic strategy for APS patients with acute coronary syndrome.
Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, 80 Pradnicka Street, 31-202 Krakow, Poland. rafal_grzybczak@interia.pl
Rafal
R
Grzybczak
Anetta
A
Undas
Pawel
P
Rostoff
Andrzej
A
Gackowski
Urszula
U
Czubek
Katarzyna
K
Stopyra
Wieslawa
W
Piwowarska
D054058:Acute Coronary Syndrome / Q000097:blood / Q000209:etiology* / Q000628:therapy; D000328:Adult; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001777:Blood Coagulation; D023921:Coronary Stenosis / Q000097:blood / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D008670:Metals; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology / Q000628:therapy*; D011474:Prosthesis Design; D012008:Recurrence; D015607:Stents; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
D008670:Metals