Efficient one-pot synthesis of novel spirooxindole derivatives via three-component reaction in aqueous medium.
A novel and efficient one-pot synthesis of spiro[indoline-3,4'-pyrazolo[3,4-b]quinoline]dione, spiro[furo[3,4-e]pyrazolo[3,4-b]pyridine-4,3'-indoline]dione, and spiro[indeno[2,1-e]pyrazolo[3,4-b]pyridine-4,3'-indoline]dione derivatives via three-component reaction of isatin, 5-amino-3-methylpyrazole, and 1,3-dicarbonyl compounds in aqueous medium is described. The advantages of this method include high efficiency, mild reaction conditions, convenient operation, and environmentally benign conditions.
Chen
Hui
H
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, PR China.
Shi
Daqing
D
D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D054852:Small Molecule Libraries; D013141:Spiro Compounds; D014867:Water