Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.
This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 approximately 20.4 microg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
Xiao
Wei-Lie
WL
Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
Wang
Rui-Rui
RR
Zhao
Wei
W
Tian
Ren-Rong
RR
Shang
Shan-Zhai
SZ
Yang
Liu-Meng
LM
Yang
Jian-Hong
JH
Pu
Jian-Xin
JX
Zheng
Yong-Tang
YT
Sun
Han-Dong
HD
D000096:Acetone / Q000737:chemistry; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D032141:Schisandra / Q000737:chemistry*
D019380:Anti-HIV Agents; D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; C552115:rubisandrin C; D000096:Acetone