Anti-ischemia steroidal saponins from the seeds of Allium fistulosum.
Six new furostanol saponins (1-6), named fistulosaponins A-F, three known furostanol saponins (7-9), and seven known aromatic compounds were isolated from seeds of Welsh onion (Allium fistulosum). The structures of these compounds were characterized by spectroscopic analyses including 2D NMR spectroscopy, mass spectrometry, and acid hydrolysis. The protective effect of the saponins on hypoxia-induced human umbilical vein endothelial cell injury was evaluated.
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415#, Shanghai 200003, People's Republic of China.
Wei
W
Lai
Zhijun
Z
Wu
Houwen
H
Lin
Tiejun
T
Li
Lianna
L
Sun
Yifeng
Y
Chai
Wansheng
W
Chen
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019697:Onions / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D012503:Saponins; D013261:Sterols