[Correlation between atherosclerosis--coronary disease and insulin resistance, regarded as the basis of metabolic syndrome].
OBJECTIVE
To analyze the components of metabolic syndrome from patients with cardiovascular disease (myocardial infarction).


METHODS
Two groups of patients are included in this study-patients who have myocardial infarction (35) and patients who have myocardial infarction associated with diabetes mellitus (47). Patients, male and female are between 43 and 86 years. For these patients was studied: the presence of dyslipidemia, the control of diabetic disease, the pancreatic secretion (insulinemia, C peptid), the index of the insulin resistance, presence of obesity and HBP, proinflammatory status, value of homocystein and of GGT.


RESULTS
The most frequent component of metabolic syndrome was dyslipidemia. More patients had abnormal value of glycemia, the expression of an inefficient control of diabetic disease. Low levels of pancreatic secretion were found frequently in patients with glycoregulation disorder. Pathological value of insulin resistance index was found in the majority of patients with diabetes mellitus.


CONCLUSIONS
the patients with metabolic syndrome had a high risk of cardiovascular disease due to metabolic disorders (dyslipidemia, hyperglycemia) and proinflammatory status.
Universitatii de Medicină şi Farmacie Gr. T. Popa Iaşi, Spitalul Clinic Judeţean de Urgenţe Sf. Spiridon Iaşi, Ambulatoriul de Specialitate.
Cecilia
C
Mihalcea
G I
GI
Pandele
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D006710:Homocysteine; D014280:Triglycerides; D005723:gamma-Glutamyltransferase; C069812:gamma-glutamyltransferase related enzyme