[Blood detoxification using superparamagnetic nanoparticles (magnetic hemodialysis)].
The authors present an experimental study realized in order to simulate blood detoxification with the help of supermagnetic nanoparticles. The particles used are red oxide nanoparticles which are considered to be equivalent from a magnetic susceptibility and dynamic diameter point of view to the complex structures of magnetite nanoparticles.


METHODS
Two types of custom HGMS matrices have been used--a threaded one and a micro-spheres one. For testing red oxide particles have been purposefully created to have a lower magnetic susceptibility than magnetite or iron-carbon particles used in other experimental studies. Different concentrations of iron oxide, glycerine and water have been prepared, creating a 3.5 cP viscosity (equivalent to the one of the blood); the concentrations of the prepared solutions varied between 0.16 mg/mL and 2 mg/mL, with the background magnetic field value ranging from 0.25 T to 0.9 T, in order to observer the effectiveness of filtering at different intensities.


RESULTS
The efficiency of HGMS filtering in experimental conditions was almost completely successful (99.99%) in all experimental conditions, both with the threaded and micro-spheres matrices.


CONCLUSIONS
The high gradient magnetic separation system of nanoparticles has maximum efficiency and has the potential of being implemented in a medical blood detoxification device.
Ciochină
Al D
AD
Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Bioinginerie Medicală.
Untu
Alina
A
Iacob
Gh
G
D005290:Ferric Compounds; D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008280:Magnetics / Q000295:instrumentation*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology; D006435:Renal Dialysis / Q000379:methods
D005290:Ferric Compounds; C000499:ferric oxide