Formulation and evaluation of novel micellar nanocarrier for nasal delivery of sumatriptan.
OBJECTIVE
The investigation was aimed at designing a micellar nanocarrier of sumatriptan for nose-to-brain delivery and to identify the probable pathway of drug transport to the brain.


METHODS
Micellar nanocarriers were formulated using various safe and acceptable excipients. Optimized formulation was characterized for particle size by multiangle dynamic light scattering, small-angle neutron scattering and cryo-transmission electron microscopy. (99m)Tc was used as a radiolabeling agent to radiolabel sumatriptan for in vivo studies.


RESULTS
Various characterization studies demonstrated the nanometric, homogenous and spherical nature of the developed micellar nanocarrier. Biodistribution and autoradiography studies in rats showed a significantly higher brain uptake of sumatriptan micellar nanocarrier as compared with sumatriptan solution.


CONCLUSIONS
Preliminary investigations in rats indicated the potential of the developed micellar nanocarrier for nose-to-brain delivery of sumatriptan. These investigations in lower animals provided an excellent lead to further evaluate the formulation in higher animals and finally in clinical settings.
Department of Pharmaceutical Sciences & Technology Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai 400 019, India.
Ratnesh
R
Jain
Swapna
S
Nabar
Prajakta
P
Dandekar
Puthusserickal
P
Hassan
Vinod
V
Aswal
Yeshayahu
Y
Talmon
Tanuja
T
Shet
Lalit
L
Borde
Krishanu
K
Ray
Vandana
V
Patravale
D000281:Administration, Intranasal; D000818:Animals; D001345:Autoradiography; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D020285:Cryoelectron Microscopy; D004337:Drug Carriers; D008297:Male; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D051381:Rats; D017208:Rats, Wistar; D012542:Scattering, Radiation; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013056:Spectrophotometry, Ultraviolet; D018170:Sumatriptan / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D004337:Drug Carriers; D008823:Micelles; D017366:Serotonin Receptor Agonists; D018170:Sumatriptan