CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer.
Accumulated evidence suggested that cytotoxic T-lymphocyte antigen 4 (CTLA4) plays an important role in the negative regulation of T-cell proliferation and activation, and thus participates in antitumor immunity and cancer surveillance. Previously we reported that the CTLA4 49A/G (rs231775) single nucleotide polymorphism (SNP) was a candidate cancer susceptibility marker for breast, lung, esophageal, and gastric cancers. In the present study, we expanded our study to two infection-related cancers, namely, hepatocellular carcinoma (HCC) and cervical cancer. We genotyped rs231775 in two independent case-control studies of 864 HCC patients and 864 control subjects, and 719 cervical cancer patients and 719 control subjects. In the multivariate logistic regression models, CTLA4 +49 A/G variant genotype was associated with increased risk (AA vs GG) by 1.43-fold (95% CI = 0.94-2.17) for HCC, and 1.66-fold (95% CI = 1.13-2.44) for cervical cancer. Taken together, the results suggest that CTLA4 rs231775 may serve as a common cancer susceptibility marker.
Laboratory of Reproductive Medicine, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Lingmin
L
Hu
Jibin
J
Liu
Xiaojun
X
Chen
Yixin
Y
Zhang
Li
L
Liu
Jian
J
Zhu
Jianguo
J
Chen
Hongbing
H
Shen
Fulin
F
Qiang
Zhibin
Z
Hu
D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D015703:Antigens, CD / Q000235:genetics*; D060908:CTLA-4 Antigen; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000150:complications; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008572:Menarche; D008875:Middle Aged; D010298:Parity; D036801:Parturition; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D017697:Premenopause; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics*
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human