New cytotoxic tetrahydroprotoberberine-aporphine dimeric and aporphine alkaloids from Corydalis turtschaninovii.
Two new tetrahydroprotoberberine-aporphine dimeric alkaloids, corydaturtschines A (1) and B (2), and a new aporphine derivative, ethyl glausuccinate (3), together with 13 known protoberberine (4-16) and nine known aporphine alkaloids (17-25), were isolated from the tubers of Corydalis turtschaninovii. The structures of these new compounds were determined through spectral analyses, including extensive 2D-NMR data. The absolute configurations of the compounds were clarified by CD spectroscopic studies. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Ki Hyun
KH
Kim
Cheng Jie
CJ
Piao
Sang Un
SU
Choi
Mi Won
MW
Son
Kang Ro
KR
Lee
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D031311:Corydalis / Q000737:chemistry*; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D035281:Plant Tubers / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D001600:Berberine Alkaloids; D010936:Plant Extracts; C557361:corydaturtschine A; C557362:corydaturtschine B; C557363:ethyl glausuccinate