Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004.
Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1%) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.
Department of Pathology, Wonju College of Medicine Yonsei University, Wonju, Korea.
Mee-Yon
MY
Cho
Jin Hee
JH
Sohn
Joon Mee
JM
Kim
Kyoung-Mee
KM
Kim
Young Su
YS
Park
Woo Ho
WH
Kim
Jin Sook
JS
Jung
Eun Sun
ES
Jung
So-Young
SY
Jin
Dae Young
DY
Kang
Jae Bok
JB
Park
Ho Sung
HS
Park
You Duck
YD
Choi
Sun Hee
SH
Sung
Young-Bae
YB
Kim
Hogeun
H
Kim
Young-Kyung
YK
Bae
Miseon
M
Kang
Hee Jin
HJ
Chang
Yang Seok
YS
Chae
Hee Eun
HE
Lee
Do Youn
DY
Park
Youn Soo
YS
Lee
Yun Kyung
YK
Kang
Hye Kyung
HK
Kim
Hee-Kyung
HK
Chang
Soon Won
SW
Hong
Young Hee
YH
Choi
Okran
O
Shin
MiJin
M
Gu
Youn Wha
YW
Kim
Gwang Il
GI
Kim
Sei Jin
SJ
Chang
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D009418:S100 Proteins / Q000378:metabolism; D012737:Sex Factors; D016019:Survival Analysis
D018952:Antigens, CD34; D009418:S100 Proteins