Two cases of treatment with infliximab which replaced long-term home parenteral nutrition and maintained remission in patients with Crohn disease.
[Case 1] A 41-year-old man had undergone multiple bowel resections and consequently short bowel syndrome with high-output jejunostomy developed. In July 2008, he started infliximab (IFX) treatment and achieved remission and recovery from cholestatic liver damage following the cessation of home parenteral nutrition (HPN). [Case 2] A 29-year-old woman chose HPN over enteral nutrition because of high-output fecal fluids through a rectovaginal fistula. Treatment with IFX and dietary control reduced her perianal discomfort. In these 2 patients, treatment with IFX successfully replaced long-term HPN which maintained remission, and improved quality of life.
Department of Gastroenterology, Osaka Rosai Hospital, Japan. shibunari@gh.med.osaka-uac.jp
Narihiro
N
Shibukawa
Riichiro
R
Nezu
Maiko
M
Murata
Masako
M
Sato
Katsuhisa
K
Noda
Masaki
M
Hirota
Yukinori
Y
Yamada
Harumasa
H
Yoshihara
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000601:surgery / Q000628:therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008297:Male; D016331:Parenteral Nutrition, Home
D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab