Photodynamic therapy with acridine orange in musculoskeletal sarcomas.
Limb salvage involving wide resection and reconstruction is now well established for managing musculoskeletal sarcomas. However, involvement of major nerves and vessels with a large volume of muscle and skin may result in a useless limb, contributing to depression and a low quality of life. We have been studying alternative treatments for musculoskeletal sarcoma since 1990, and have recently established a regime using photodynamic surgery with cells labelled with acridine orange, photodynamic therapy with cells treated similarly and radiodynamic treatment using the effect of X-rays on such cells. These techniques have been used after marginal or intralesional resection of tumours since 1999 and have enabled maintenance of excellent limb function in patients with sarcomas.
Department of Orthopaedic Surgery Mie University Graduate School of Medicine, Edobashi 2-174 Tsu City, Japan.
T
T
Matsubara
K
K
Kusuzaki
A
A
Matsumine
H
H
Murata
Y
Y
Marunaka
S
S
Hosogi
A
A
Uchida
A
A
Sudo
D000165:Acridine Orange / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy; D005240:Feasibility Studies; D006801:Humans; D023821:Limb Salvage / Q000379:methods; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy
D017319:Photosensitizing Agents; D000165:Acridine Orange