Five-year trend of acquired antitubercular drug resistance in patients attending a tertiary care hospital at Dehradun (Uttarakhand).
OBJECTIVE
To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs.


METHODS
Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were subjected to culture and sensitivity testing against common antitubercular drugs.


RESULTS
Growth of Mycobacterium tuberculosis was obtained from sputum specimen of 184 (85.58%) of the 215 patients who were studied; Overall, 113 (62.77%) of these were resistant to at least one antitubercular drug. Resistance to isoniazid was most common (62.22%) followed by rifampicin (57.22%). Multidrug resistance (MDR) was observed in 103 (57.22%) cases. During the five-year study period, an increasing trend in drug resistance including MDR-TB was observed.


CONCLUSIONS
This study showed increasing trend in drug resistance including MDR-TB in five years.
Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Swami Rama Nagar, Doiwala, Dehradun (Uttaranchal), India.
Jagdish
J
Rawat
G
G
Sindhwani
Ruchi
R
Juyal
Ruchi
R
Dua