Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.
A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated.
Shanab
Karem
K
Department of Drug and Natural Product Synthesis, University of Vienna, Austria.
Schirmer
Eva
E
Knafl
Heike
H
Wulz
Eva
E
Holzer
Wolfgang
W
Spreitzer
Helmut
H
Schmidt
Peter
P
Aicher
Babette
B
Müller
Gilbert
G
Günther
Eckhard
E
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009285:Naphthoquinones; D011758:Pyrroles