Right posterior cortical functions in a tumour patient series.
It is standardly believed that the localisation of cognitive function by means of impairments arising from cortical tumour is not possible as the functional defects that result are mild and unspecific. These assumptions were not supported in an investigation of four processes generally sensitive to right posterior cortical lesions, when patients with parieto-occipital lesions were compared with prefrontal ones. In three of the tests loading on the individual processes - Reaching Accuracy, Star Cancellation, Fragmented Letters and Cube Analysis - parieto-occipital impairments were found in the basic groups analysis and this was so in the right-hemisphere group. More critically, in these tests Lesion Behaviour Mapping showed the critical lesion site for the tests to have relatively little overlap with those of the other tests, indicating that the cognitive effects were not widespread and diffuse. In addition, in three of the tests the critical lesion sites fitted localisations arrived from other procedures. Patients with high-grade tumours performed considerably worse than those with low-grade tumours in only two of the tests (Star Cancellation, Cube Analysis) particularly in the right parieto-occipital group. In three (Reaching Accuracy, Star Cancellation, Cube Analysis) there was a deterioration with the operation specifically in the low-grade tumour patients. It is suggested that a tumour patient series may provide converging evidence for the localisation of a function initially obtained by some other procedure.
Shallice
Tim
T
Cognitive Neuroscience Sector, SISSA-ISAS, Trieste, Italy. shallice@sissa.it
Mussoni
Alessandro
A
D'Agostino
Serena
S
Skrap
Miran
M
D000328:Adult; D001259:Ataxia / Q000503:physiopathology; D001288:Attention; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003071:Cognition; D005133:Eye Movements; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D010364:Pattern Recognition, Visual; D011597:Psychomotor Performance; D013028:Space Perception; D014785:Vision, Ocular; D014794:Visual Fields; D014796:Visual Perception