Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles.
Three-component reactions with 3,4-diiodoalk-2-enoic derivatives, primary amines, and terminal alkynes proceeded to give trisubstituted pyrroles in fair to good yields in the presence of palladium and copper catalysts under mild reaction conditions.
Lamandé-Langle
Sandrine
S
Groupe S.U.C.R.E.S-UMR 7565 Nancy Université- CNRS, BP 70239, F-54506, Nancy Vandoeuvre, France.
Abarbri
Mohamed
M
Thibonnet
Jérôme
J
Duchêne
Alain
A
Parrain
Jean-Luc
JL
D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D000588:Amines; D011758:Pyrroles; D010165:Palladium; D003300:Copper