Ménage à Trio during BMP-Mediated Retrograde Signaling at the NMJ.
In flies, retrograde BMP signaling is an important mechanism by which postsynaptic cells regulate the structure and function of presynaptic terminals, ostensibly through changes in gene expression. Transcriptional targets, however, have remained mysterious. In this issue of Neuron, Haghighi and colleagues begin to unravel this puzzle by identifying the cytoskeletal regulator Trio.
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Yuly
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Fuentes-Medel
Vivian
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Budnik