Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.
Medical Research Council UK, The Gambia.
Louis-Marie
LM
Yindom
Aleksandra
A
Leligdowicz
Maureen P
MP
Martin
Xiaojiang
X
Gao
Ying
Y
Qi
Syed M A
SM
Zaman
Maarten Schim
MS
van der Loeff
Carla
C
van Tienen
Assan
A
Jaye
Akum
A
Aveika
Archibald
A
Worwui
Mathurin
M
Diatta
Tim
T
Vincent
Hilton C
HC
Whittle
Sarah L
SL
Rowland-Jones
Robert
R
Walton
Mary
M
Carrington
D000328:Adult; D000354:Africa, Western; D000368:Aged; D018450:Disease Progression; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D015498:HIV-2 / Q000276:immunology* / Q000472:pathogenicity; D015235:HLA-B Antigens / Q000235:genetics; D015795:HLA-B8 Antigen; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics*
D015235:HLA-B Antigens; C509422:HLA-B*08:01 antigen; D015795:HLA-B8 Antigen; D015395:Histocompatibility Antigens Class I; D054340:Receptors, KIR