Immobilization of povidone-iodine on surfaces of silica gel particles and bactericidal property.
A novel antibacterial material I(2)-PVP/SiO(2), on which povidone-iodine (PVP-I(2)) was loaded, was synthesized by a two-step route. Polyvinylpyrrolidone (PVP) was firstly graft-polymerized onto the surfaces of micro-sized silica gel particles, obtaining the grafted particles PVP/SiO(2). Subsequently, the grafted particles PVP/SiO(2) were allowed to undergo a complexation reaction with iodine, resulting in a water-insoluble antibacterial material, I(2)-PVP/SiO(2). The effects of various factors on the complexation reaction were examined. The antibacterial property of I(2)-PVP/SiO(2) was investigated by using Escherichia coli (E. coli) as model bacterium and with the colony count method. The experimental results show that the fitting temperature for the complexation reaction between PVP/SiO(2) and I(2) is 60 degrees C, and the complexation reaction reaches equilibrium after 12 h. The particles I(2)-PVP/SiO(2) have very strong antibacterial activity and they have the sterilizing mechanism similar to povidone-iodine.
Department of Chemical Engineering, North University of China, Taiyuan 030051, People's Republic of China. gaobaojiao@126.com
Baojiao
B
Gao
Zhanbin
Z
Wang
Qing
Q
Liu
Ruikui
R
Du
D000042:Absorption; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005562:Formazans / Q000737:chemistry; D007455:Iodine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011206:Povidone-Iodine / Q000737:chemistry* / Q000494:pharmacology*; D015203:Reproducibility of Results; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013242:Sterilization; D013499:Surface Properties / Q000187:drug effects; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005562:Formazans; D058428:Silica Gel; D012822:Silicon Dioxide; D011206:Povidone-Iodine; D007455:Iodine