18F-FDG PET/CT evaluation of lymphoma with renal involvement: comparison with renal carcinoma.
OBJECTIVE
Lymphoma can arise at any anatomic site, but it is rare to find kidney involvement. The aim of this study was to assess the role of F-flourodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) in detecting lymphoma with renal involvement. Reports of such use of F-FDG PET/CT are limited.


METHODS
Twelve lymphoma patients with renal involvement and 12 renal carcinoma patients were studied with F-FDG PET/CT. Intense F-FDG uptake, suggestive of positivity, was measured in mean standardized uptake values (standardized uptake values [SUV] mean).


RESULTS
The results of PET/CT were validated by bone marrow, biopsy tissue and/or surgery. F-FDG PET/CT detected lymphoma with renal involvement lesions or renal carcinoma lesions in at least one site in the 24 patients. F-FDG uptake by the lymphoma lesions was much higher than the F-FDG uptake by the renal clear cell carcinomas (SUV mean 6.37 +/- 2.28 vs 2.58 +/- 0.62), and similar to that of renal cell carcinoma and renal collecting duct carcinoma (SUV mean 6.37 +/- 2.28 vs 6.27 +/- 1.15). There were dissimilar morphological changes in the homologous CT. Differing from renal cancer, lymphoma in the spleen, uterus, and bone marrow can easily be diagnosed by F-FDG PET/CT.


CONCLUSIONS
The lesions of lymphoma with renal involvement, and especially those of primary renal lymphoma, are F-FDG avid. PET/CT appears to be useful in comparing these lesions with those of renal carcinoma, especially for primary renal lymphoma.
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangdong 510515, China.
Xiang-Hua
XH
Ye
Long-Hua
LH
Chen
Hu-Bing
HB
Wu
Jie
J
Feng
Wen-Lan
WL
Zhou
Rui-Meng
RM
Yang
Zhi-Bin
ZB
Bu
Yi
Y
Ding
Jian
J
Guan
Quan-Shi
QS
Wang
D000293:Adolescent; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008223:Lymphoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D055815:Young Adult
D019788:Fluorodeoxyglucose F18