Hypolipidemic and antioxidant activity of Anthocephalus indicus (Kadam) root extract.
The present study was carried out to explore the anti-diabetic, anti-dyslipoproteinemic and anti-oxidant activities of Anthocephalus indicus root extract in alloxan-induced (150 mg/kg body wt.) diabetic rats. A marked increase in plasma levels of glucose and lipid peroxides accompanied with an elevation in the lipids and apoprotein levels of serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL) following decrease in lipid and protein constituents of high density lipoprotein (HDL) were observed. The alterations in lipoprotein pattern was associated with inhibition of lipolytic and antioxidant enzymes. Oral administration of root extract (500 mg/kg body wt.) for 30 days in dyslipidemic animals resulted in significant decrease in plasma glucose, total cholesterol, phospholipids, triglyceride and lipid peroxides. The decrease of lipids and apoprotein levels of VLDL and LDL were followed by stimulation of plasma post-heparin lipolytic activity and lecithin cholesterol acyltransferase as well as hepatic superoxide dismutase and catalase activities. Lipid and apoprotein levels of HDL were also recovered partially on treatment with root extract.
Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow 226001.
Vishnu
V
Kumar
Farzana
F
Mahdi
Ramesh
R
Chander
Ranjana
R
Singh
Abbas Ali
AA
Mahdi
Ashok Kumar
AK
Khanna
Sanjay
S
Bhatt
Rajeev Singh
RS
Kushwaha
Kalbe
K
Jawad
Jitendra Kumar
JK
Saxena
Raj Kumar
RK
Singh
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001647:Bile Acids and Salts / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005243:Feces; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D014197:Trees / Q000737:chemistry*
D000975:Antioxidants; D001647:Bile Acids and Salts; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D008054:Lipid Peroxides; D010936:Plant Extracts