The quest to understand heterotrimeric G protein signaling.
Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.
Tesmer
John J G
JJ
Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA. tesmerjj@umich.edu
D000818:Animals; D006160:Guanosine Triphosphate / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D012243:Rhodopsin / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D043562:Receptors, G-Protein-Coupled; D006160:Guanosine Triphosphate; D012243:Rhodopsin; D020962:Heterotrimeric GTP-Binding Proteins