Identification of two new HLA-DRB1 alleles, DRB1*040405 and DRB1*1190.
We describe here two novel DRB1 alleles, officially named *040405 and *1190. DRB1*040405 differs from DRB1*0404 for one point mutation at codon 72 with no coding changes. DRB1*1190 is identical to DRB1*110101 except for a nucleotide substitution at codon 24 which causes an aminoacidic mutation from valine to methionine. Over time we have been witnessing the identification of a great number of new HLA alleles. DRB1 allelic variability is mostly present in the second exon and more that 760 alleles have been so far identified. Here, we report the description of two novel DRB1 alleles, named *040405 and *1190, and identified in two Caucasoid subjects.
Organ and Tissue Transplantation Immunology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via Francesco Sforza 35, Milan, Italy.
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Mantovani
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Longhi
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Frison
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Espadas de Arias
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Mosca
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Poli
D000483:Alleles; D001483:Base Sequence; D005091:Exons; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D017421:Sequence Analysis
D059811:HLA-DRB1 Chains