Systemic therapies in managing sinonasal inflammation.
Chronic rhinosinusitis (CRS) is a condition characterized by persistent inflammation due to intrinsic mucosal hypersensitivity or persistent infection. Proper medical treatment with antibiotic, leukotriene modifiers, oral corticosteroids, or even aspirin desensitization for the sinus inflammation can prevent the need for surgical intervention. The key to delineating the specific medical application is to determine the cause of the sinus mucosa dysfunction and its specific inflammatory pathway. Such targeted antiinflammatory medical therapy will lead to improved efficacy in the management of CRS. Even if surgical intervention is required, postoperative medical treatment is essential to minimizing the intrinsic mucosal inflammation and therefore preventing revision endoscopic procedures.
Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, 600 Gresham Drive, Suite 1100, Norfolk, VA 23507, USA.
Michael A
MA
DeMarcantonio
Joseph K
JK
Han
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004358:Drug Therapy / Q000379:methods*; D004804:Eosinophils; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D048448:Phenylcarbamates; D012220:Rhinitis / Q000150:complications* / Q000188:drug therapy* / Q000601:surgery; D012852:Sinusitis / Q000150:complications* / Q000188:drug therapy* / Q000601:surgery; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D006633:Histamine Antagonists; D007155:Immunologic Factors; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; C063449:zileuton; D006918:Hydroxyurea; C062735:zafirlukast