IL-16 polymorphism and risk of renal cell carcinoma: association in a Chinese population.
OBJECTIVE
Interleukin-16 (IL-16) plays a fundamental role in inflammatory diseases, as well as in the development and progression of tumors. A T-to-C polymorphism at the -295 position in the promoter region of the IL-16 gene has been described. This variation might lead to altered IL-16 expression, and might modulate an individual's susceptibility to cancer. The objective of the present study was to determine if IL-16 polymorphism is associated with risk of renal cell carcinoma (RCC).


METHODS
A case-control study including 335 RCC cases and 340 cancer-free controls was carried out. All subjects were genetically unrelated ethnic Han Chinese recruited from a single institution between July 2006 and July 2009. The IL-16 -295 T>C polymorphism was determined by using the polymerase chain reaction-restriction fragment length polymorphism method. Serum samples were available for 70 RCC cases and 96 controls to detect IL-16 concentration.


RESULTS
Compared with the IL-16 -295 TT genotype, the CC genotype had a significantly decreased RCC risk (adjusted odds ratio [OR] = 0.34, 95% confidence interval [CI] = 0.18-0.66). Furthermore, a significant decreased risk of RCC was found in the combined variant genotypes CT + CC compared with the TT genotype (adjusted OR = 0.68, 95% CI = 0.50-0.93). In addition, the serum IL-16 levels in RCC patients were significantly lower than those in controls (P < 0.001). Furthermore, patients carrying CC genotype or CT genotype had higher serum IL-16 levels than TT carriers.


CONCLUSIONS
IL-16 -295 T>C polymorphism is significantly associated with a higher risk of developing RCC in Chinese population.
Zhu
Jian
J
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qin
Chao
C
Yan
Fu
F
Wang
Meilin
M
Ding
Qi
Q
Zhang
Zhengdong
Z
Yin
Changjun
C
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000208:ethnology / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D019410:Interleukin-16 / Q000097:blood* / Q000235:genetics*; D007680:Kidney Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D019410:Interleukin-16