Chronic kidney disease and GWAS: "the proper study of mankind is man".
Genome-wide association studies (GWAS) have been applied to complex diseases such as diabetes and hypertension, successfully uncovering strong gene associations of potential pathophysiologic significance. Recently, two studies (Köttgen et al., 2010; Chambers et al., 2010) have been applied to uncover genes relevant to the pathophysiology of chronic kidney disease (CKD).
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Peter M
PM
Price
Kurt
K
Hirschhorn
Robert L
RL
Safirstein