Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes.
Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15 % soybean oil (control group); 15 % palm oil (PO); and 15 % PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.
Cheng
Hsing-Hsien
HH
School of Nutrition and Health Science, Taipei Medical University, Taipei, Taiwan.
Ma
Chien-Ya
CY
Chou
Tsui-Wei
TW
Chen
Ya-Yen
YY
Lai
Ming-Hoang
MH
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy*; D004032:Diet / Q000009:adverse effects; D005243:Feces / Q000737:chemistry; D005951:Glucose Tolerance Test; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D000073878:Palm Oil; D010666:Phenylpropionates / Q000627:therapeutic use*; D010938:Plant Oils / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D000073879:Rice Bran Oil; D013261:Sterols / Q000032:analysis; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D001647:Bile Acids and Salts; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D010666:Phenylpropionates; D010938:Plant Oils; D013261:Sterols; D014280:Triglycerides; C030104:lipoprotein cholesterol; D000073878:Palm Oil; D002784:Cholesterol; D000073879:Rice Bran Oil; C013172:gamma-oryzanol