A discrepancy between serological and molecular typing results led to identification of a novel HLA-B*57 allele: HLA-B*5728N.
Summary Here, we describe the characterisation of a new allelic variant of HLA-B*57. The novel allele, HLA-B*5728N, was identified with sequence-based typing in a Caucasoid family. HLA-B*5728N, differs from HLA-B*5701 because of a nucleotide substitution at position 420 (C->G) resulting in a coding change from Tyrosine to a stop codon.
Cosentini
E
E
Immunohematology and Transfusion Medicine, Federico II University, Naples, Italy.
Frison
S
S
Longhi
E
E
Mantovani
M
M
Luongo
V
V
Ciardiello
G
G
Bruno
P
P
Poli
F
F
D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D018388:Codon, Terminator; D005091:Exons / Q000235:genetics; D005260:Female; D005805:Genes, MHC Class I; D015235:HLA-B Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012698:Serologic Tests; D044465:White People / Q000235:genetics
D018388:Codon, Terminator; D015235:HLA-B Antigens; C103707:HLA-B57 antigen