Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry.
The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A.
Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 77842-3012, USA. brian.bachmann@vanderbilt.edu
Brian O
BO
Bachmann
Ruth
R
McNees
Bruce J
BJ
Melancon
Victor P
VP
Ghidu
Rachel
R
Clark
Brenda C
BC
Crews
Sean M
SM
Deguire
Lawrence J
LJ
Marnett
Gary A
GA
Sulikowski
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
D018942:Macrolides; D011753:Pyrones; C506738:apoptolidin A; C552165:apoptolidin G