[A community-based study on relations between metabolic syndrome and carotid atherosclerosis in a middle-aged population].
OBJECTIVE
To explore the association between metabolic syndromes (MS) and carotid atherosclerosis and to estimate the predictive effects of MS under 3 different definitions.


METHODS
A cross-sectional study was conducted in 2 community-based populations in Beijing, in 2008. 1266 subjects (598 men, 668 women), aged 45 - 69, were included in the analyses. MS was defined by the criteria of International Diabetes Federation (IDF), the revised NCEP ATP III (ATPIII-R) and "The Guidelines of Dyslipidemia Control for Chinese Adult" ("Guidelines") in 2007.


RESULTS
The prevalence rates of MS by the 3 criteria were 39.0%, 43.3% and 30.9% respectively. The Kappa value for the measure of the agreement between each pair of the 3 definitions were 0.911, 0.719 and 0.730 respectively. The intima-media thickness in common carotid artery (CCA-IMT) was significantly higher (P < 0.001) in all MS groups than in non-MS groups, diagnosed with the 3 criteria independent of age, gender, LDL-C, and current smoking status. After adjustment of age, gender, LDL-C, and current smoking status, the classification of MS significantly increased the risk of prevalence of carotid atherosclerotic plaques, compared to the non-MS group. OR value were 1.499 (95%CI: 1.157 - 1.942) for IDF, 1.696 (95%CI: 1.314 - 2.189) for NCEP-R, 1.763 (95%CI: 1.344 - 2.312) for "Guideline" respectively.


CONCLUSIONS
Our research findings indicated that, when MS were defined with the 3 definitions, prediction on the risk of sub-clinical atherosclerosis would work beyond some of the conventional cardiovascular risk factors such as smoking, LDL-C. There might exist some differences in gender issue on the strength of association between MS when diagnosed by different criteria and carotid plaque.
Department of the Network for Prevention and Control, Cardiovascular Institute, Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.
Xiao-xuan
XX
Zou
Ying
Y
Li
Hong-ju
HJ
Zhang
Zuo
Z
Chen
Hao
H
Wang
Min
M
Guo
Qian-qian
QQ
Wang
Lian-cheng
LC
Zhao
Ying
Y
Yang
Run-ping
RP
Zheng
Yu-ling
YL
Cai
Dong-feng
DF
Gu
D000368:Aged; D002340:Carotid Artery Diseases / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors