Vitamin D receptor activators and response to injury in kidney diseases.
Clinical studies have confirmed that administration of vitamin D receptor (VDR) activators offers a survival benefit in hemodialysis patients and may help in preservation of renal function in predialysis patients. Accumulated clinical and mainly experimental data support that in the context of kidney disease, VDR activators exert their beneficial effect not only due to their action on calcium and phosphorus homeostasis, but also through modulation of the response to injury. They attenuate systemic and renal inflammation, and they affect the tissue repair process, reducing renal fibrosis. This aspect of the functions of VDR activators in kidney disease is reviewed in the present manuscript.
Department of Nephrology, General Hospital of Serres, Serres, Greece.
Theodoros
T
Eleftheriadis
Georgia
G
Antoniadi
Vassilios
V
Liakopoulos
Nikolaos
N
Antoniadis
Ioannis
I
Stefanidis
Grammati
G
Galaktidou
D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D007674:Kidney Diseases / Q000188:drug therapy*; D018167:Receptors, Calcitriol / Q000187:drug effects / Q000502:physiology*; D006435:Renal Dialysis
D007155:Immunologic Factors; D018167:Receptors, Calcitriol