Clinical outcome in dogs with nasal tumors treated with intensity-modulated radiation therapy.
Intensity-modulated radiation therapy (IMRT) is a valuable tool in human radiation oncology, but information on its use in veterinary medicine is lacking. In this study, 12 dogs with nasal tumors were treated with IMRT at a median radiation dose of 54 Gy. Patient survival times and frequency and severity of side effects on ocular structures, oral mucosa, and skin were recorded. Eight dogs (67%) had resolution of clinical signs during radiation therapy. Median overall survival time was 446 d with a 50% 1-year and a 25% 2-year survival rate. Minimal grade 2 or 3 acute skin toxicity, no grade 2 or 3 late skin toxicity, and no grade 2 or 3 toxicity to oral mucosa or the eye opposite the tumor were identified in the dogs treated with IMRT in this study. The ipsilateral eye could not be routinely spared due to its proximity to the tumor.
Ocean State Veterinary Specialists, East Greenwich, Rhode Island 02818, USA. dhunley@osvs.net
David W
DW
Hunley
G Neal
GN
Mauldin
Keijiro
K
Shiomitsu
Glenna E
GE
Mauldin
D000818:Animals; D004283:Dog Diseases / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D053208:Kaplan-Meier Estimate; D008297:Male; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D011879:Radiotherapy Dosage / Q000662:veterinary; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D013997:Time Factors; D016896:Treatment Outcome