Colchicine-loaded lipid bilayer-coated 50 nm mesoporous nanoparticles efficiently induce microtubule depolymerization upon cell uptake.
We report on a one-step assembly route where supported lipid bilayers (SLB) are deposited on functionalized colloidal mesoporous silica (CMS) nanoparticles, resulting in a core-shell hybrid system (SLB@CMS). The supported membrane acts as an intact barrier against the escape of encapsulated dye molecules. These stable SLB@CMS particles loaded with the anticancer drug colchicine are readily taken up by cells and lead to the depolymerization of microtubules with remarkably enhanced efficiency as compared to the same dose of drug in solution.
Cauda
Valentina
V
Department of Chemistry, University of Munich (LMU), Munich, Germany.
Engelke
Hanna
H
Sauer
Anna
A
Arcizet
Delphine
D
Bräuchle
Christoph
C
Rädler
Joachim
J
Bein
Thomas
T
D045744:Cell Line, Tumor; D003078:Colchicine / Q000008:administration & dosage* / Q000494:pharmacology*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D008870:Microtubules / Q000187:drug effects*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D050257:Tubulin Modulators / Q000008:administration & dosage* / Q000494:pharmacology*
D008051:Lipid Bilayers; D050257:Tubulin Modulators; D012822:Silicon Dioxide; D003078:Colchicine