Use of combined liothyronine and thyroxine therapy for consumptive hypothyroidism associated with hepatic haemangiomas in infancy.
Hepatic haemiangiomas in infancy are rare. An association with hypothyroidism has been previously reported and is believed to be secondary to the conversion of thyroxine (fT4) to biologically inactive reverse triiodothyronine (rT3) by type 3 iodothyronine deiodinase (D3). We report a case that responded well to the combined use of liothyronine and thyroxine therapy.
Department of Paediatric Endocrinology, Great Ormond Street Hospital and Institute for Child Health, London, UK.
Catherine
C
Peters
Shirley
S
Langham
Primus E
PE
Mullis
Mehul T
MT
Dattani
D006391:Hemangioma / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy*; D007223:Infant; D007453:Iodide Peroxidase / Q000378:metabolism; D008113:Liver Neoplasms / Q000150:complications* / Q000188:drug therapy; D008297:Male; D013974:Thyroxine / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000627:therapeutic use*; D014285:Triiodothyronine, Reverse / Q000378:metabolism
D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D007453:Iodide Peroxidase; D013974:Thyroxine