A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
To identify genetic susceptibility loci for nasopharyngeal carcinoma (NPC), a genome-wide association study was performed using 464,328 autosomal SNPs in 1,583 NPC affected individuals (cases) and 1,894 controls of southern Chinese descent. The top 49 SNPs from the genome-wide association study were genotyped in 3,507 cases and 3,063 controls of southern Chinese descent from Guangdong and Guangxi. The seven supportive SNPs were further confirmed by transmission disequilibrium test analysis in 279 trios from Guangdong. We identified three new susceptibility loci, TNFRSF19 on 13q12 (rs9510787, Pcombined=1.53x10(-9), odds ratio (OR)=1.20), MDS1-EVI1 on 3q26 (rs6774494, Pcombined=1.34x10(-8), OR=0.84) and the CDKN2A-CDKN2B gene cluster on 9p21 (rs1412829, Pcombined=4.84x10(-7), OR=0.78). Furthermore, we confirmed the role of HLA by revealing independent associations at rs2860580 (Pcombined=4.88x10(-67), OR=0.58), rs2894207 (Pcombined=3.42x10(-33), OR=0.61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules.
Bei
Jin-Xin
JX
State Key Laboratory of Oncology in Southern China, Guangzhou, China.
Li
Yi
Y
Jia
Wei-Hua
WH
Feng
Bing-Jian
BJ
Zhou
Gangqiao
G
Chen
Li-Zhen
LZ
Feng
Qi-Sheng
QS
Low
Hui-Qi
HQ
Zhang
Hongxing
H
He
Fuchu
F
Tai
E Shyong
ES
Kang
Tiebang
T
Liu
Edison T
ET
Liu
Jianjun
J
Zeng
Yi-Xin
YX
D044466:Asian People / Q000235:genetics; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D005838:Genotype; D006801:Humans; D000074008:MDS1 and EVI1 Complex Locus Protein; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011519:Proto-Oncogenes / Q000235:genetics; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D000074008:MDS1 and EVI1 Complex Locus Protein; C063575:MECOM protein, human; D009363:Neoplasm Proteins; D018124:Receptors, Tumor Necrosis Factor; C411850:TNFRSF19 protein, human; D014157:Transcription Factors