Ca(2+) homeostasis and structural and functional remodelling of airway smooth muscle in asthma.
Asthma is characterised by airway hyper-responsiveness and remodelling, and there is mounting evidence that alterations in the phenotype of airway smooth muscle (ASM) play a central role in these processes. Although the concept that dysregulation of ASM Ca(2+) homeostasis may underlie at least part of these alterations has been around for many years, it is only relatively recently that the availability of ASM biopsies from subjects with mild and moderate asthma has allowed it to be properly investigated. In this article, critical components of the pathobiology of asthmatic ASM, including contractile function, proliferation, cell migration and secretion of proinflammatory cytokines and chemokines, are reviewed and related to associated changes in ASM Ca(2+) homeostasis. Based on this evidence, it is proposed that a unifying mechanism for the abnormal asthmatic phenotype is dysregulation of Ca(2+) homeostasis caused at least in part by a downregulation in expression and function of sarcoendoplasmic Ca(2+) ATPases (SERCAs).
King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
Katharina
K
Mahn
Oluwaseun O
OO
Ojo
Gianna
G
Chadwick
Philip I
PI
Aaronson
Jeremy P T
JP
Ward
Tak H
TH
Lee
D056151:Airway Remodeling / Q000502:physiology*; D001249:Asthma / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000503:physiopathology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000502:physiology
D016207:Cytokines; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium