In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum.
The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D 6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC(50) values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC(50) values were 0.040 and 5.54 µg/mL, respectively.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. liuailin@imm.ac.cn
Ai-Lin
AL
Liu
Fan
F
Yang
Mian
M
Zhu
Dan
D
Zhou
Mao
M
Lin
Simon Ming-Yuen
SM
Lee
Yi-Tao
YT
Wang
Guan-Hua
GH
Du
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D035684:Gnetum / Q000737:chemistry*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000378:metabolism; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D010936:Plant Extracts; D013267:Stilbenes; D014764:Viral Proteins; D009439:Neuraminidase