Electrophilic aromatic selenylation: new OPRT inhibitors.
2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.
Abdo
Mohannad
M
Department of Chemistry & Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA.
Zhang
Yong
Y
Schramm
Vern L
VL
Knapp
Spencer
S
D006801:Humans; D008288:Malaria / Q000201:enzymology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009962:Orotate Phosphoribosyltransferase / Q000037:antagonists & inhibitors; D012643:Selenium / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; D009962:Orotate Phosphoribosyltransferase; D012643:Selenium