Calcium concentration in cochlear endolymph after vestibular labyrinth injury.
The endolymphatic calcium concentration [Ca2+] is essential for acoustic transduction. This study investigated the changes in cochlear function caused by vestibular labyrinth destruction in the acute phase by measurement of the endocochlear potential and endolymphatic [Ca2+].Hartley guinea pigs underwent lateral semicircular canal transection with suctioning of the perilymph, ampullectomy, or destruction of the lateral part of the vestibule. The endocochlear potential and endolymphatic [Ca2+] showed mild change after lateral semicircular canal transection with suctioning or ampullectomy. However, the endocochlear potential decreased drastically and permanently, and the endolymphatic [Ca2+] elevated suddenly but finally normalized after vestibulotomy. Elevated endolymphatic [Ca2+] is important in the disturbance of the mechanism of cochlear function caused by vestibular labyrinth destruction.
Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine, Sendai 980-8574, Japan. ryoukich@hotmail.com
Ryoukichi
R
Ikeda
Kazuhiro
K
Nakaya
Takeshi
T
Oshima
Tetsuaki
T
Kawase
Toshimitsu
T
Kobayashi
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003051:Cochlea / Q000503:physiopathology*; D004710:Endolymph / Q000378:metabolism*; D006168:Guinea Pigs; D054777:Hair Cells, Ampulla / Q000502:physiology; D008297:Male; D008564:Membrane Potentials; D010498:Perilymph; D012665:Semicircular Canals / Q000293:injuries / Q000503:physiopathology; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000293:injuries*
D002118:Calcium