Radiochemical determination of cross sections of alpha-particle induced reactions on 192Os for the production of the therapeutic radionuclide 193mPt.
For determination of cross sections of alpha-particle induced reactions on 99.65% enriched (192)Os, the methods for electrolytic preparation of thin samples and radiochemical separation of radioplatinum were optimized. The excitation functions of the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n) (193m)Pt reactions were measured from 20 to 39 MeV. The cross section of the latter reaction reaches a maximum value of about 1.5b at an energy around 36 MeV. The results of nuclear model calculations using the codes TALYS and STAPRE agreed well with the measured data. The optimum energy range for the production of no-carrier-added (193m)Pt (T(1/2)=4.33 d) was found to be E(alpha)=40-->30 MeV. The thick target yield amounts to 10 MBq/microA h and a possible batch yield of 2 GBq should be sufficient for Auger electron therapy on a wide scale.
Institut für Neurowissenschaften und Medizin, INM-5, Nuklearchemie, Forschungszentrum Jülich, D-52425 Jülich, Germany.
M S
MS
Uddin
B
B
Scholten
A
A
Hermanne
S
S
Sudár
H H
HH
Coenen
S M
SM
Qaim
D000512:Alpha Particles; D008962:Models, Theoretical; D009992:Osmium; D010984:Platinum / Q000302:isolation & purification / Q000627:therapeutic use; D011854:Radiochemistry / Q000379:methods; D011868:Radioisotopes / Q000302:isolation & purification / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000627:therapeutic use
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D009992:Osmium; D010984:Platinum