Quality and quantity control of proteins in senescence.
Autophagy has been implicated in aging and age-related diseases but its roles in these processes are far from straightforward: the anti-aging effect of autophagy has been shown in lower eukaryotes, and both pro- and anti-tumorigenic effects of autophagy have also been demonstrated. The new link between autophagy and senescence provides an insight into the diversified downstream effects of autophagy in various cellular contexts.
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, United Kingdom. masashi.narita@cancer.org.uk
Masashi
M
Narita
D000375:Aging / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D056890:Eukaryota