Possible andrologic markers in elevated neonatal 17-hydroxyprogesterone.
In this prospective study, we analyzed 30 male infants with increased neonatal 17-hydroxyprogesterone (17OH-P) (patients) and for comparison 52 age-matched healthy babies (control subjects) with the aim of investigating the hypothalamic-pituitary-testis axis in the first 6 months of life. Although T, FSH, and LH levels were not significantly different in patients and control subjects, inhibin B was higher in patients than in control subjects. Therefore we suggest a clinical follow-up of these babies during childhood and puberty to verify the evolution of their condition.
Pediatric Clinic, Department of Mother and Child, University of Verona, Verona, Italy. paolocavarzere@yahoo.it
Paolo
P
Cavarzere
Monica
M
Vincenzi
Rossella
R
Gaudino
Roberto
R
Franceschi
Silvia
S
Perlini
Marta
M
Camilot
Francesca
F
Teofoli
Franco
F
Antoniazzi
Luciano
L
Tatò
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood* / Q000378:metabolism; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D033441:Andrology / Q000379:methods; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D016022:Case-Control Studies; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D015997:Neonatal Screening / Q000379:methods; D013255:Steroid 21-Hydroxylase / Q000378:metabolism; D015854:Up-Regulation
D015415:Biomarkers; D019326:17-alpha-Hydroxyprogesterone; D013255:Steroid 21-Hydroxylase