Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation.
FeS cluster biogenesis is an essential process in virtually all forms of life. Complex protein machineries that are conserved from bacteria through higher eukaryotes facilitate assembly of the FeS cofactor in proteins. In the last several years, significant strides have been made in our understanding of FeS cluster assembly and the functional overlap of this process with cellular iron homeostasis. This minireview summarizes the present understanding of the cytosolic iron-sulfur cluster assembly (CIA) system in eukaryotes, with a focus on information gained from studies in budding yeast and mammalian systems.
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612.
Anil K
AK
Sharma
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612.
Leif J
LJ
Pallesen
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612.
Robert J
RJ
Spang
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois 60612. Electronic address: wwalden@uic.edu.
William E
WE
Walden
D000818:Animals; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism*
D007506:Iron-Sulfur Proteins; D029701:Saccharomyces cerevisiae Proteins; D013455:Sulfur; D007501:Iron