Fitting model of ABR age dependency in a clinical population of normal hearing children.
The purpose of this study was to present a simple and powerful fitting model that describes age-dependent changes of auditory brainstem responses (ABR) in a clinical population of normal hearing children. A total of 175 children (younger than 200 weeks postconceptional age) were referred for audiologic assessment with normal ABR results. ABR parameters of normal hearing children between 2003 and 2008 were included. The results of the right ears recorded at 90 dB nHL were analyzed. A simple and accurate fitting model was formulated based on these data. A very similar age-dependent effect was found for peaks III and V, and I-III and I-V intervals; latencies decrease as postconceptional age increases. It shows that the total age-dependent effect will be completed after 1.5-2 years. The age-dependent effect can be modeled by a relatively simple and accurate exponential function. This fitting model can be easily implemented to analyze ABR results of infants in daily clinical practice. We speculate about the underlying physiological processes.
Department of Otorhinolaryngology, Sophia Children's Hospital, Erasmus Medical Center, SP-1455, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands. s.coenraad@erasmusmc.nl
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Coenraad
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van Immerzeel
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Hoeve
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Goedegebure
D000367:Age Factors; D000465:Algorithms; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006309:Hearing / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D015233:Models, Statistical; D011930:Reaction Time; D012016:Reference Values