Lung procurement for transplantation: new criteria for lung donor selection.
In Italy, like everywhere in the world, the organ shortage for transplantation is a real problem. It is well known that lung donors (LD) are particularly difficult to procure and that management of the organ do not care during the diagnosis of cerebral death represents a difficult challenge. In this context, the salvage of the so-called "marginal donors" may increase the pool of donors, favoring organ retrieval. To increase lung procurement, the intensivist must recognize "marginal donors," optimizing organ selection and function. The aim of our study was to review LD procured in 2008, as identified by the unrestricted criteria, of the Nord Italian Transplant program Center (NITp). Particularly, the age and habits of donors and the presence of a parenchyma contusion were not sufficient per se to exclude donation. We revisited lung ventilation and monitoring modalities during cerebral death before retrieval. In 2008, the application of enlarged criteria for LD enabled us to collect 21 LD, namely 33% of all cerebral deaths, versus 13% in 2007. Seeking to maintain good gas exchange and lung function, we implemented a safe ventilation program avoided high peak pressures, and fluid therapy properly guided by the cardiac index and extravascular lung water index monitoring. Specific actions to improve LD procurement may help cope with the organ-donor shortage. Although our series was small, our results were encouraging; they underline the necessity to continuously review donor criteria and care, allowing good donor/recipient matching.
Neurointensive Care, AO Niguarda Ca' Granda, Milano, Italy. coordinatoreprelievo@ospedaleniguarda.it
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MP
Moretti
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Betto
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Gambacorta
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Vesconi
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Scalamogna
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Benazzi
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Ravini
D000328:Adult; D000368:Aged; D001926:Brain Death; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011013:Pneumonectomy / Q000379:methods; D014019:Tissue Donors / Q000706:statistics & numerical data; D020858:Tissue and Organ Harvesting; D009927:Tissue and Organ Procurement / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data