Pentraxin-3 in late-preterm newborns with hypoxic respiratory failure.
The aim of this study was: echocardiographical assessment of cardiac alterations in late-preterm newborns with hypoxic respiratory failure (HRF), and, study serum pentraxin-3 (PTX-3) in relation to the severity of respiratory impairment and to some echocardiographic parameters (i.e. ejection fraction (EF), stroke volume (SV) and cardiac output (CO). We enrolled in this study 40 newborn infants whose 22 (group I) with moderate HRF and 18 (group II) with severe HRF. In group I the mean values of EF, SV and CO were significantly higher than in the group II. Our results showed a significant increase of PTX-3 in group II patients at 24h of life when compared to group I. Taking patients all together (n=40), we found a significant (R=-73) reverse correlation between EF and serum values of PTX-3. PTX-3 in our patients with HRF is affected by the severity of the hypoxic insult and correlate with the cardio-vascular impairment.
Sciacca
Pietro
P
Department of Pediatrics, Unit of Neonatology and Pediatric Cardiology, University of Catania, Via S Sofia 78, 95125 Catania, Italy.
Betta
Pasqua
P
Mattia
Carmine
C
Li Volti
Giovanni
G
Frigiola
Alessandro
A
Curreri
Sergio
S
Amato
Maurizio
M
Distefano
Giuseppe
G
D002097:C-Reactive Protein / Q000032:analysis*; D004452:Echocardiography; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000097:blood* / Q000503:physiopathology; D000683:Serum Amyloid P-Component / Q000032:analysis*; D000099153:Pentraxins
D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins