[Role of prognostic factors in evaluation of survival in breast cancer].
The aim of our study is to evaluate the prognostic value of tumor size, regional lymph nodes and steroid-hormones receptors status, histological grade, and the presence of metastasis in other organs.


METHODS
Our retro-prospective study analyzes a group of 266 patients diagnosed and treated for breast cancer in the IVth Obstetrics and Gynecology Clinic.


RESULTS
150 of the patients (56.7%) presented stage I disease, and only 39 (14.7%) stage IV. 151 (57%) of the patients had no regional lymph nodes metastasis and 252 (94.9%) were free of metastatic disease when they first presented for diagnosis. Almost 43% of all tumors were poorly differentiated. In the majority of cases, the tumors were positive for steroid receptors. The survival rate after 5 years was higher in the absence of lymph nodes metastasis (76%) and the presence of a low Nottingham prognostic index (78%).


CONCLUSIONS
The identification and evaluation of prognostic factors is an essential step for treatment planning and limiting metastatic disease.
Universitatea de Medicină şi Farmacie Gr. T. Popa laşi Facultatea de Medicină, Clinica a IV(-a) Obstetrică Ginecologie.
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D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011987:Receptors, Steroid / Q000032:analysis; D012383:Romania / Q000453:epidemiology; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D014408:Biomarkers, Tumor; D011987:Receptors, Steroid; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A