Hidden reach of the micromanagers.
Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens.
Linsley
Peter S
PS
Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA. plinsley@regulusrx.com
Jackson
Aimee L
AL
D017209:Apoptosis / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods*; D008957:Models, Genetic; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism
D034741:RNA, Small Interfering; D053221:TNF-Related Apoptosis-Inducing Ligand