[Acroosteolysis in PVC autoclave cleaners: history of an occupational disease].
OBJECTIVE
This paper examines the history of an occupational disease which has now disappeared: acroosteolysis of manual tank cleaners in the production of polyvinyl chloride (PVC), which is a rare disease characterized by destructive alterations of the distal phalanges of the hands.


METHODS
All the available literature on this disease was examined. The history of acroosteolysis was studied within the general framework of the history of the discovery of adverse health effects of exposure to vinyl chloride, and this history was studied up to the end of the 1960's.


RESULTS
The disease was observed for the first time in mid-1963 in Belgium (Jemeppe) in a chemical plant operated by Solvay, and affected two workers whose job was the manual cleaning of vessels used for the polymerization of vinyl chloride; similar cases occurred in almost all PVC production plants all over the world, but not in the plants where the main activity was the production of vinyl chloride monomer (VCM). Little more than one hundred cases are described in the scientific literature, and this number increases by a few dozen if we consider known but unpublished cases. These figures confirm the rarity of the disease, which peaked at the end of the 1960's and disappeared during the 1970's, probably due to the complete elimination of manual reactor cleaning. Observation of the disease lasted no more than fifteen years and the disease was not replicated in experimental conditions on animals.


CONCLUSIONS
The disease was clinically characterized, had a short latency (from several months to several years), was rare and unequivocally linked to the manual cleaning of PVC polymerization tanks. However many questions still remain open: the period when the disease first appeared (many years after the start of PVC production in the world), the etiology of the disease (the most accredited hypothesis considers three concomitant factors: a chemical factor--one of the many substances used during polymerization, and particularly vinyl chloride monomer, a physical factor--microtraumas of the fingers during manual cleaning, individual susceptibility), the pathogenetic mechanism (in particular: the role of skin, respiratory, or digestive system, as entrance door), a method (or test) to screen subjects potentially predisposed to the disease. In our view acroosteolysis of manual tank cleaners in PVC production is an occupational disease which is distinct from "vinyl chloride disease" as identified by Viola (1974).
Zocchetti
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Osservatorio Epidemiologico, Direzione Generale Sanità, Regione Lombardia, Milano. carlo_zocchetti@regione.lombardia.it
Osculati
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Colosio
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D030981:Acro-Osteolysis / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000266:history* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005060:Europe / Q000453:epidemiology; D006230:Hand Injuries / Q000150:complications; D049673:History, 20th Century; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000266:history* / Q000503:physiopathology; D011143:Polyvinyl Chloride / Q000009:adverse effects*; D013242:Sterilization / Q000295:instrumentation*; D014481:United States / Q000453:epidemiology
D011143:Polyvinyl Chloride