Pneumoproteins and inflammatory biomarkers in asphalt pavers.
Pneumoproteins, biomarkers of systemic inflammation and endothelial activation were studied across a season in 72 asphalt pavers, 32 asphalt plant operators and 19 asphalt engineers. Smokers had lower concentrations of Clara cell protein (CC-16) and surfactant protein A, but higher concentrations of surfactant protein D, interleukin 6, C-reactive protein, fibrinogen and intercellular adhesion molecule (ICAM)-1 than non-smokers. Smokers reporting wheezing had lower mean CC-16 concentration than smokers not reporting wheezing (5.7 vs 8.6 microg l(-1); p = 0.05). Cholesterol, P-selectin and ICAM-1 were lower in pavers and operators at the end compared with the start of the season. This may be related to increased physical activity during the season.
Ellingsen
Dag G
DG
National Institute of Occupational Health, Oslo, Norway. dag.ellingsen@stami.no
Ulvestad
Bente
B
Andersson
Lena
L
Barregard
Lars
L
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D003252:Construction Materials; D016207:Cytokines / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005340:Fibrinogen; D006801:Humans; D006838:Hydrocarbons; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6; D016014:Linear Models; D008168:Lung / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016273:Occupational Exposure / Q000032:analysis*; D019007:P-Selectin; D011506:Proteins / Q000737:chemistry*; D012129:Respiratory Function Tests; D012140:Respiratory Tract Diseases / Q000453:epidemiology; D012621:Seasons; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry; D011795:Surveys and Questionnaires; D055815:Young Adult
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; D006838:Hydrocarbons; D015850:Interleukin-6; D019007:P-Selectin; D011506:Proteins; C006647:asphalt; D005340:Fibrinogen