[Hepatic cell transplantation: a new therapy in liver diseases].
Liver transplantation has been remarkably effective in the treatment in patients with end-stage liver disease. However, disparity between solid-organ supply and increased demand is the greatest limitation, resulting in longer waiting times and increase in mortality of transplant recipients. This situation creates the need to seek alternatives to orthotopic liver transplantation.Hepatocyte transplantation or liver cell transplantation has been proposed as the best method to support patients. The procedure consists of transplanting individual cells to a recipient organ in sufficient quantity to survive and restore the function. The capacity of hepatic regeneration is the biological basis of hepatocyte transplantation. This therapeutic option is an experimental procedure in some patients with inborn errors of metabolism, fulminant hepatic failure and acute and chronic liver failure, as a bridge to orthotopic liver transplantation. In the Hospital La Fe of Valencia, we performed the first hepatocyte transplantation in Spain creating a new research work on transplant program.
Unidad de Cirugía y Trasplante Hepático, Hospital Universitario La Fe, Valencia, España. pareja_eug@gva.es
Eugenia
E
Pareja
Miriam
M
Cortés
Amparo
A
Martínez
Juan José
JJ
Vila
Rafael
R
López
Eva
E
Montalvá
Angeles
A
Calzado
José
J
Mir
D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D008107:Liver Diseases / Q000601:surgery*