[Role of Th17 cells in rheumatoid arthritis].
Th17 cells are the newly described subset of the CD4(+) T lymphocytes. Activated Th17 cells are characterized by their ability to produce IL-17A and other pro-inflammatory cytokines. IL-17A regulates immune function through its cell-surface receptor expressed on epithelial-and endothelial cells, fibroblasts and leukocytes by promoting neutrophil recruitment and releasing further pro-inflammatory mediators. Failures of the susceptible balance of the immunoregulation may lead to unchecked immune response and autoimmune diseases. The central role of Th17 cells and cytokines produced by Th17 cells were confirmed in a wide variety of human autoimmune diseases, including rheumatoid arthritis. Recently Th17 cells and its cytokines come into the focus of immunological research as potential therapeutic targets.
Magyar Tudományos Akadémia-Semmelweis Egyetem, Gyermekgyógyászati és Nefrológiai Kutatócsoport, Budapest. himernori@gmail.com
Leonóra
L
Himer
Attila
A
Balog
Beáta
B
Szebeni
Dorottya Nagy
DN
Szakál
Erna
E
Sziksz
György
G
Reusz
Tivadar
T
Tulassay
Adám
A
Vannay
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015551:Autoimmunity; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D018123:Receptors, Interleukin / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
C448419:IL17RC protein, human; D020381:Interleukin-17; D018123:Receptors, Interleukin