Neuroinflammation in Huntington's disease.
Huntington's disease (HD) is a monogenic neurodegenerative disease characterized by abnormal motor movements, personality changes and early death. In contrast to other neurodegenerative diseases, very little is known about the role of neuroinflammation in HD. While the current data clearly demonstrate the existence of inflammatory processes in HD pathophysiology, the question of whether neuroinflammation is purely reactive or might actively participate in disease pathogenesis is currently a matter of ongoing research and debate. This review will try to shed some light on the current state of research in this area and provide an outlook on potential future developments.
Möller
Thomas
T
Department of Neurology, School of Medicine, University of Washington, Box 356465, 1959 NE Pacific Street, Seattle, WA 98195, USA. moeller@u.washington.edu
D002118:Calcium / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism; D004660:Encephalitis / Q000150:complications*; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000276:immunology*; D007737:Kynurenine / Q000378:metabolism; D017628:Microglia / Q000502:physiology*
D007737:Kynurenine; D003165:Complement System Proteins; D005293:Ferritins; D002118:Calcium