[Hyperreactive luteomas during pregnancy--symptoms and complications: a case report].
A 27-year-old Caucasian (gravida 2 para 1) presented in week 16 of her twin pregnancy with worsening of hyperandrogenic symptoms. In week 17, she developed an acute abdomen due to a twisted, incarcerated right ovary, which was surgically removed. Histological analysis revealed a diffuse steroid cell hyperplasia. Postsurgery testosterone levels fell temporarily within normal limits, diminishing the hyperandrogenic symptoms. Over time androgen levels rose again slowly above normal values with clinical worsening of hirsutism. In the 32nd week of gestation, a cesarean section of two healthy female infants was necessary due to the development of preeclampsia. An ovarian biopsy revealed again the picture of hyperreactio luteinalis. Postpartum peripheral hormone levels fell within normal limits and the hyperandrogenic symptoms subsided.
Abteilung für gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsfrauenklinik Heidelberg, Vossstrasse 9, Heidelberg, Germany. Ariane_Germeyer@med.uni-heidelberg.de
Ariane
A
Germeyer
Friedrich
F
Kommoss
Thomas
T
Strowitzki
Michael
M
von Wolff
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D007231:Infant, Newborn; D010535:Laparoscopy; D018311:Luteoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D010053:Ovary / Q000473:pathology; D011247:Pregnancy; D011272:Pregnancy, Multiple