Spontaneous intracranial hypotension-hypovolemia associated with tacrolimus.
There is little precedent for a medication-induced spontaneous intracranial hypotension/cerebrospinal fluid (CSF) hypovolemia (SIH). This case history of a woman with low CSF pressure, orthostatic headache, and radiographic findings consistent with SIH but without a detectable leak was notable for its association, both onset and resolution, with the use of the calcineurin inhibitor tacrolimus (FK506). A literature review for potential causes of a tacrolimus-induced CSF hypotension suggests many potential mechanisms of action, including effects on blood brain barrier and dural compliance, and supports further vigilance for this condition in the medically complex setting of tacrolimus use.
Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Andrew H
AH
Ahn
Brian D
BD
Berman
William P
WP
Dillon
D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy; D006261:Headache / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D020896:Hypovolemia / Q000139:chemically induced* / Q000503:physiopathology*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D019585:Intracranial Hypotension / Q000139:chemically induced* / Q000503:physiopathology*; D016031:Liver Transplantation / Q000379:methods; D008875:Middle Aged; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016559:Tacrolimus