Effects of keratinocyte growth factor-2 on corneal epithelial wound healing in a rabbit model of carbon dioxide laser injury.
Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a member of the fibroblast growth factor family. It plays a critical role in epithelial development and exerts its biological activities in a paracrine manner on the receptor FGFR2-IIIb. This study examined the function of topically applied KGF-2 in vivo on wound healing using a CO(2) laser, corneal epithelial wounded, rabbit model. Topically applied 25 microg/ml KGF-2 accelerated corneal epithelial wound healing, in contrast to the control, and reduced inflammation, stromal edema, and fibrosis. In addition, this factor also exhibited significant inhibition of corneal neovascularization. KGF-2 appears to be another important growth factor in the regulation of corneal epithelial wound healing.
Wang
Xiaojie
X
School of Public Health, Jilin University, Changchun 130021, China.
Zhou
Xin
X
Ma
Jisheng
J
Tian
Haishan
H
Jiao
Yue
Y
Zhang
Rui
R
Huang
Zhifeng
Z
Xiao
Jian
J
Zhao
Binhai
B
Qian
Huanwen
H
Li
Xiaokun
X
D000287:Administration, Topical; D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D019573:Epithelium, Corneal / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D051526:Fibroblast Growth Factor 10 / Q000494:pharmacology / Q000627:therapeutic use*; D005355:Fibrosis / Q000188:drug therapy / Q000209:etiology; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology; D054020:Lasers, Gas; D011817:Rabbits; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D051526:Fibroblast Growth Factor 10; D051497:Receptor, Fibroblast Growth Factor, Type 2