Designed short peptides that form amyloid-like fibrils in coassembly with amyloid beta-peptide (Abeta) decrease the toxicity of Abeta to neuronal PC12 cells.
Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, B40, 4259 Nagatsuta, Yokohama 226-8501, Japan.
Miho
M
Suzuki
Tsuyoshi
T
Takahashi
Junichi
J
Sato
Masayasu
M
Mie
Eiry
E
Kobatake
Hisakazu
H
Mihara
D000596:Amino Acids; D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015195:Drug Design; D009474:Neurons / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats
D000596:Amino Acids; D000682:Amyloid; D016229:Amyloid beta-Peptides; D009842:Oligopeptides