Special delivery for MHC II via autophagy.
In this issue of Immunity, Blanchet et al. (2010) report that human immunodeficiency virus-1 inhibits macroautophagy in dendritic cells, attenuating MHC II presentation. Lee et al. (2010) previously revealed the requirement of autophagic machinery for MHC II presentation of herpes viral antigens.
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.
Andrew P
AP
Hayward
S P
SP
Dinesh-Kumar