Analysis of familial incidence of non-syndromic cleft lip and palate in a Brazilian population.
BACKGROUND
The purpose of this study is to follow the familial incidence of non-syndromic or isolated cleft lip, with or without cleft palate (NSCL/P), and to analyze the relationships between the type of NSCL/P in the affected individual and his/her parent, looking at children in the first grade.


METHODS
To investigate the familial incidence of NSCL/P we analyzed the records of 185 patients from 2004-2008, retrospectively. Detailed histories were collected regarding the familial incidence of NSCL/P. For the 185 individuals, the relationship between the type of NSCL/P and the sociodemographic and personal characteristics of the affected person and her/his cleft relatives was obtained.


RESULTS
The individuals were 42 carriers of CL, 109 with CLP (joined in one group) and 34 with CP (p<0.001). Of the total of participants, 65 (35.13%) presented a positive history of cleft in their families and 120 (64.86%) presented a negative history (p<0.001). There were differences between the cleft groups according to types of cleft and positive familial history (p<0.001). In both groups, the relatives with higher incidence of NSCL/P were cousins, with the same pattern of distribution between the two groups (p=0.175).


CONCLUSIONS
Most frequently, fissures result from CL/CLP with no familial history. However, CL/CLP was found in familial cases and cousins were the relative type more likely to be affected.
Stomatology Clinic, Dental School, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
Daniella-Reis
DR
Martelli
Paulo-Rogério-Ferreti
PR
Bonan
Matheus-Carvalho
MC
Soares
Lívia-Ribeiro
LR
Paranaíba
Hercílio
H
Martelli-Júnior
D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002971:Cleft Lip / Q000453:epidemiology* / Q000235:genetics*; D002972:Cleft Palate / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult