Unilateral tongue angioedema caused by angiotensin-converting enzyme inhibitor.
OBJECTIVE
We report a case of an elderly man receiving treatment with perindopril, who presented with angioedema of the left side of the tongue, floor of the mouth and upper neck. This affected his speech and swallowing, and occurred one day after a burr hole and evacuation procedure undertaken to treat a subdural haematoma. The patient was kept under close observation and treated with intravenous hydrocortisone. The angioedema resolved completely in two days. This is the third reported case of unilateral tongue angioedema occurring secondary to angiotensin-converting enzyme inhibitor use.


METHODS
Case report and literature review concerning angiotensin-converting enzyme inhibitor induced angioedema.


CONCLUSIONS
Unilateral angioedema of the tongue is a rare adverse reaction to angiotensin-converting enzyme inhibitors. Early recognition may prevent unnecessary surgical intervention and complications.
Department of Otorhinolaryngology, University Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.
Y S
YS
Ee
A J
AJ
Sow
B S
BS
Goh
D000368:Aged; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D006801:Humans; D008297:Male; D020913:Perindopril / Q000009:adverse effects*; D013997:Time Factors; D014060:Tongue Diseases / Q000139:chemically induced*
D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril