Polymer- and liposome-based nanoparticles in targeted drug delivery.
This review focuses on polymer- and liposome-based nanoparticles used in targeted delivery of bioactive molecules, from drugs to siRNA to pDNA. The perspective centers around commercial and clinical successes, and a rationalization of these successes. Microparticulate systems are not covered, and only those applications that truly utilize the advantages of nano size are covered. "Stealth" systems dominate in this review, as most of the clinical successes are for passive targeting rather than for active targeting of tissue. The relevance of nano size to gene delivery is also discussed with relevant examples.
Venkatraman
Subbu S
SS
School of Material Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore. ASSubbu@ntu.edu.sg
Ma
Lwin Lwin
LL
Natarajan
Jayaganesh V
JV
Chattopadhyay
Sujay
S
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004655:Emulsions; D005822:Genetic Vectors; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry
D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D008823:Micelles; D011108:Polymers