Antibiotic susceptibility of intra-abdominal infection isolates from Indian hospitals during 2008.
A total of 542 clinical isolates of aerobic Gram-negative bacilli from intra-abdominal infections were collected during 2008 from seven hospitals in India participating in the Study for Monitoring Antimicrobial Resistance Trends (SMART). Isolates were from various infection sources, the most common being gall bladder (30.1 %) and peritoneal fluid (31.5 %), and were mostly hospital-associated isolates (70.8 %) as compared to community-acquired (26.9 %). The most frequently isolated pathogens were Escherichia coli (62.7 %), Klebsiella pneumoniae (16.7 %) and Pseudomonas aeruginosa (5.3 %). Extended-spectrum beta-lactamase (ESBL) rates in E. coli and K. pneumoniae were very high, at 67 % and 55 %, respectively. Most isolates exhibited resistance to one or more antibiotics. The most active drugs were generally ertapenem, imipenem and amikacin. However, hospital-acquired isolates in general, as well as ESBL-positive isolates, exhibited lower susceptibilities than community-acquired isolates. Further surveillance monitoring of intra-abdominal isolates from India is recommended.
Hawser
Stephen P
SP
IHMA Europe Sàrl, Epalinges, Switzerland.
Badal
Robert E
RE
International Health Management Associates Inc., Schaumburg, IL, USA.
Bouchillon
Samuel K
SK
International Health Management Associates Inc., Schaumburg, IL, USA.
Hoban
Daryl J
DJ
International Health Management Associates Inc., Schaumburg, IL, USA.
The Smart India Working Group
IHMA Europe Sàrl, Epalinges, Switzerland.
D000005:Abdomen / Q000473:pathology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007194:India / Q000453:epidemiology
D000900:Anti-Bacterial Agents