Contribution of Cyclophilin A to determination of simian immunodeficiency virus tropism: a progress update.
An understanding of cellular factors that affect viral replication contributes to elucidation of the mechanism for the determination of viral tropism. Cyclophilin A (CypA), a peptidyl-prolyl cis-trans isomerase (PPIase), is an essential host factor for the efficient replication of human immunodeficiency virus type 1 (HIV-1) in human cells. However, its role in simian immunodeficiency virus (SIV) replication has not been determined. In the 2008 US-Japan AIDS panel meeting, I have presented the effect of cyclosporine A (CsA), a PPIase inhibitor, on replication of wild-type SIV. Interestingly, CsA treatment enhanced SIV replication in human cells but abrogated SIV replication in macaque cells, implying a species-specific effect of CsA on SIV replication. After this meeting, analysis using CypA knocked-down human cells indicated that CypA was considered inhibitory for SIV replication. These results suggest possible involvement of CypA in the determination of SIV tropism.
Takeuchi
Hiroaki
H
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. htake@ims.u-tokyo.ac.jp
D000818:Animals; D002460:Cell Line; D021984:Cyclophilin A / Q000378:metabolism*; D016572:Cyclosporine / Q000494:pharmacology; D055785:Gene Knockdown Techniques; D016346:Gene Products, vif; D006801:Humans; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D013045:Species Specificity; D056189:Viral Tropism; D014779:Virus Replication
D016346:Gene Products, vif; D016572:Cyclosporine; D021984:Cyclophilin A