Genetic risk factors for inflammatory bowel disease in a North-eastern Mexican population.
The purpose of this study was to assess the role of Helicobacter pylori and several genetic polymorphisms in relation to inflammatory bowel disease (IBD). We studied 44 unrelated patients with IBD and 75 subjects with no history of IBD as controls. Using pyrosequencing technology, we identified gene polymorphisms in IL-10, TNF-A, ILB-31, and TLR4. H. pylori status was determined by serology. Individuals homozygous for IL10-592 A or IL10-1082 A genotypes show significantly lower occurrence of IBD (P=0.03 and P<0.01, respectively). Individuals heterozygous at IL10-1082 have significantly increased occurrence of IBD, both ulcerative colitis and Crohn's disease (P<0.01). There was no difference in the prevalence of H. pylori infection between cases and controls. This study provides evidence that variation in IL10 is correlated with IBD occurrence in this Mexican population.
Garza-González
E
E
Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Av. Madero s/n Colonia Mitras Centro, CP 64460 Monterrey, Nuevo León, Mexico. elvira_garza_gzz@yahoo.com
Pérez-Pérez
G I
GI
Mendoza-Ibarra
S I
SI
Flores-Gutiérrez
J P
JP
Bosques-Padilla
F J
FJ
D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
D016753:Interleukin-10