Design of an injectable synthetic and biodegradable surgical biomaterial.
We report the design of an injectable synthetic and biodegradable polymeric biomaterial comprised of polyethylene glycol and a polycarbonate of dihydroxyacetone (MPEG-pDHA). MPEG-pDHA is a thixotropic physically cross-linked hydrogel, displays rapid chain relaxation, is easily extruded through narrow-gauge needles, biodegrades into inert products, and is well tolerated by soft tissues. We demonstrate the clinical utility of MPEG-pDHA in the prevention of seroma, a common postoperative complication following ablative and reconstructive surgeries, in an animal model of radical breast mastectomy. This polymer holds significant promise for clinical applicability in a host of surgical procedures ranging from cosmetic surgery to cancer resection.
Zawaneh
Peter N
PN
Department of Biomedical Engineering, School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Singh
Sunil P
SP
Padera
Robert F
RF
Henderson
Peter W
PW
Spector
Jason A
JA
Putnam
David
D
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D004098:Dihydroxyacetone; D015195:Drug Design; D005260:Female; D006801:Humans; D020100:Hydrogels; D007267:Injections; D008408:Mastectomy / Q000009:adverse effects; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D011076:Polycarboxylate Cement; D011092:Polyethylene Glycols; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D049291:Seroma / Q000517:prevention & control
D001672:Biocompatible Materials; D020100:Hydrogels; D011076:Polycarboxylate Cement; C005506:polycarbonate; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D004098:Dihydroxyacetone