[Studies on preparation and dissolution test in vitro of sustained-release dropping pills of curcumin].
OBJECTIVE
To study the prescription and technique of sustained-release dropping pills of curcumin and inspect their release property in vitro.


METHODS
The orthogonal test was used to screen the prescription and technique which were definited with the colligation evaluation of release and formation of dropping pills.


RESULTS
The optimization of prescription and technique were as follows: stearic acid 70 mg, glycery monostearate 25 mg, solutol 6 mg, viscosity of cooling liquid was 100 mm2/s; the temperature of material liquid was 80 degrees C; the cooling temperature was 30 - 0 degrees C; the dropping speed was (21 +/- 2) dripping/min. The release behavior of sustained-release dropping pills of curcumin coincidented with Higuchi equation well and the character of sustained-release was transparent.


CONCLUSIONS
The sustained-release dropping pills of curcumin have good property of sustained-release in vitro and their release behavior in vivo need to be inspected.
Pharmacy Faculty of Hebei Medical University, Shijiazhuang 050017, China. triqq@126.com
Yu
Y
Fang
Bai
B
Xiang
Zhen-Hua
ZH
Pan
De-Ying
DY
Cao
D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry* / Q000302:isolation & purification*; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D005989:Glycerides / Q000737:chemistry; D008863:Microspheres; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility; D013229:Stearic Acids / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005989:Glycerides; D013229:Stearic Acids; D013501:Surface-Active Agents; C048159:glyceryl monostearate; D011092:Polyethylene Glycols; C067028:Solutol HS 15; D003474:Curcumin