Potency of anidulafungin compared to nine other antifungal agents tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: results from the global SENTRY Antimicrobial Surveillance Program (2008).
The SENTRY Antimicrobial Surveillance Program regularly monitors global susceptibility rates for a spectrum of both novel and established antifungal agents. Anidulafungin and the other echinocandins displayed sustained, excellent activity against Candida spp. and Aspergillus fumigatus, with >or=98% of MIC results at <or=2 microg/ml. Six yeast isolates (all Candida glabrata) showing caspofungin MIC values of >or=0.5 microg/ml were further analyzed for potential fks hot spot (HS) mutations; three isolates had confirmed mutations in the fks1 HS1 region (S645P), and three exhibited mutations in the fks2 HS1 region (S645F and S645P).
Messer
Shawn A
SA
JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA. sam-messer@jmilabs.com
Jones
Ronald N
RN
Moet
Gary J
GJ
Kirby
Jeffrey T
JT
Castanheira
Mariana
M
D019943:Amino Acid Substitution / Q000235:genetics; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000302:isolation & purification; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D003454:Cryptococcus / Q000187:drug effects* / Q000302:isolation & purification; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D020125:Mutation, Missense
D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D000077612:Anidulafungin