R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases.
R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.
Antonov
Alexey V
AV
Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Institute for Bioinformatics and Systems Biology, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany. alexey.antonov@helmholtz-muenchen.de
Schmidt
Esther E
EE
Dietmann
Sabine
S
Krestyaninova
Maria
M
Hermjakob
Henning
H
D003196:Computer Graphics; D030541:Databases, Genetic; D030562:Databases, Protein; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D025941:Protein Interaction Mapping; D011506:Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface
D011506:Proteins