Evaluation of an onion extract, Centella asiatica, and hyaluronic acid cream in the appearance of striae rubra.
This study evaluated the effect of an onion extract cream with Centella asiatica and hyaluronic acid in improving the appearance of striae rubra (SR). Women participants with bilateral, outer aspect of the thigh SR were randomized to apply a quarter-sized amount of the onion extract cream twice daily for 12 weeks to the randomized left or right, outer aspect of the thigh. No treatment was administered to the contralateral side. Participants were evaluated at weeks 2, 4, 8, and 12. Primary efficacy endpoints included color, texture, softness, and overall appearance of SR by the participant and investigator at week 12. The treated thigh demonstrated a statistically significant difference in the mean change in participant and investigator evaluations in overall appearance, texture, color, and softness compared with the untreated thigh at week 12. No adverse events occurred during the study. The onion extract cream was well tolerated and significantly improved the appearance of SR in women.
Department of Dermatology, Duke University School of Medicine, Durham, NC, USA. zdraelos@northstate.net
Zoe Diana
ZD
Draelos
Michael H
MH
Gold
Mandeep
M
Kaur
Babajide
B
Olayinka
Starr L
SL
Grundy
Eric J
EJ
Pappert
Bhushan
B
Hardas
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D028041:Centella; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D014315:Triterpenes / Q000008:administration & dosage*; D055815:Young Adult
C526146:Centella asiatica extract; D009824:Ointments; D010936:Plant Extracts; D014315:Triterpenes; D006820:Hyaluronic Acid