Evaluation of a customized artificial osteoporotic bone model of the distal femur.
In the development of new implants biomechanical testing is essential. Since human bones vary markedly in density and geometry their suitability for biomechanical testing is limited. In contrast artificial bones are of great uniformity and therefore appropriate for biomechanical testing. However, the applied artificial bones have to be proved as comparable to human bone. An anatomical shaped artificial bone representing the distal human femur was created by foaming polyurethane. To get a bone model with properties of osteoporotic bone a foam density of 150 kg/m3 was used. The biomechanical properties of our artificial bones were evaluated against eight mildly osteoporotic fresh frozen human femora by mechanical testing. At the artificial bones all tested parameters showed a very small variation. In contrast significant correlation between bone mass density and tested parameters was found for the human bones. The artificial bones reached 39% of the compression strength and 41% of the screw pullout force of the human bone. In indentation testing the artificial bones reached 27% (cancellous) and 59% (cortical) respectively of the human bones strength. Regarding Shore hardness artificial bone and human bone showed comparable results for the cortical layer and at the cancellous layer the artificial bone reached 57% of human bones hardness. Our described method for customizing of artificial bones regarding their shape and bone stock quality provides suitable results. In relation to the as mildly osteoporotic classified human bones we assume that the biomechanical properties matching to serve osteoporotic bone.
Wähnert
Dirk
D
Department of Trauma-, Hand- and Reconstructive Surgery, Friedrich Schiller University Jena, Erlanger Allee 101, 07747 Jena, Germany. Dirk.Waehnert@med.uni-jena.de
Hoffmeier
Konrad L
KL
Stolarczyk
Yves
Y
Fröber
Rosemarie
R
Hofmann
Gunther O
GO
Mückley
Thomas
T
D000368:Aged; D000369:Aged, 80 and over; D001187:Artificial Organs; D001696:Biomechanical Phenomena; D015519:Bone Density; D018786:Bone Substitutes; D019245:Compressive Strength; D005260:Female; D005269:Femur / Q000473:pathology / Q000503:physiopathology*; D006244:Hardness; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D008953:Models, Anatomic; D008954:Models, Biological; D010024:Osteoporosis / Q000473:pathology / Q000503:physiopathology*; D011140:Polyurethanes
D018786:Bone Substitutes; D011140:Polyurethanes