Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical.
Substituted trityl radicals are important spin probes for functional electron paramagnetic resonance spectroscopy and imaging including oxygen and pH mapping in vivo. Here we report the synthetic procedure for large scale synthesis of deuterated Finland trityl radical with superior EPR spectral properties and higher sensitivity towards oxygen concentrations in solution. Additionally Finland trityl radicals substituted with linkers suitable for attaching peptide, or other synthetic precursors have been synthesized. The effect of deutero-substitution on EPR spectra of homologous derivatives has been evaluated. The compounds are potential candidates for targeted spin probes in EPR imaging.
Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, 43210, USA.
Ilirian
I
Dhimitruka
Olga
O
Grigorieva
Jay L
JL
Zweier
Valery V
VV
Khramtsov
D003903:Deuterium / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D013237:Stereoisomerism; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
D005609:Free Radicals; D014320:Triphenylmethyl Compounds; D003903:Deuterium; D010100:Oxygen