In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum.
The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D 6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC(50) values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC(50) values were 0.040 and 5.54 µg/mL, respectively.
Liu
Ai-Lin
AL
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. liuailin@imm.ac.cn
Yang
Fan
F
Zhu
Mian
M
Zhou
Dan
D
Lin
Mao
M
Lee
Simon Ming-Yuen
SM
Wang
Yi-Tao
YT
Du
Guan-Hua
GH
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D035684:Gnetum / Q000737:chemistry*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000378:metabolism; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D010936:Plant Extracts; D013267:Stilbenes; D014764:Viral Proteins; D009439:Neuraminidase