Virucidal efficacy of povidone-iodine-containing disinfectants.
OBJECTIVE
The objective of this study was to evaluate virucidal efficacy of the commercially available povidone-iodine formulations Betaisodona solution and Betaseptic Mundipharma (Mundipharma).


RESULTS
The quantitative suspension test for virucidal testing of biocides according to the German guideline was used as method. The use of Betaisodona solution resulted in virucidal efficacy, corresponding to >or=10(4)-fold reduction in viral titre, against vaccinia virus, bovine viral diarrhoea virus and polyomavirus SV40 within 0.5 min and adenovirus type 5 within 3-5 min without and with organic load. For inactivation of the most resistant poliovirus type 1, a time interval of >or=60 min was needed. By contrast, Betaseptic Mundipharma inactivated significantly all model viruses for virucidal testing including poliovirus type 1 within 5 min independently from the addition of proteins.


CONCLUSIONS
Betaisodona solution shows a good efficacy against enveloped model viruses as well as against some nonenveloped human viruses, e.g. adenovirus and polyomavirus. Betaseptic Mundipharma has an excellent virucidal efficacy including the inactivation of the most resistent poliovirus type 1.


CONCLUSIONS
The findings of this study make Betaseptic Mundipharma suitable for virucidal disinfection of the skin within short time intervals.
Institute of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany. Andreas.Sauerbrei@med.uni-jena.de
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Sauerbrei
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Wutzler
D000818:Animals; D002460:Cell Line; D004202:Disinfectants / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D011206:Povidone-Iodine / Q000494:pharmacology*; D013997:Time Factors; D019562:Viral Load; D014780:Viruses / Q000187:drug effects*
D004202:Disinfectants; D011206:Povidone-Iodine