Quantification of global myocardial oxygenation in humans: initial experience.
OBJECTIVE
To assess the feasibility of our newly developed cardiovascular magnetic resonance (CMR) methods to quantify global and/or regional myocardial oxygen consumption rate (MVO2) at rest and during pharmacologically-induced vasodilation in normal volunteers.


METHODS
A breath-hold T2 quantification method is developed to calculate oxygen extraction fraction (OEF) and MVO2 rate at rest and/or during hyperemia, using a two-compartment model. A previously reported T2 quantification method using turbo-spin-echo sequence was also applied for comparison. CMR scans were performed in 6 normal volunteers. Each imaging session consisted of imaging at rest and during adenosine-induced vasodilation. The new T2 quantification method was applied to calculate T2 in the coronary sinus (CS), as well as in myocardial tissue. Resting CS OEF, representing resting global myocardial OEF, and myocardial OEF during adenosine vasodilation were then calculated by the model. Myocardial blood flow (MBF) was also obtained to calculate MVO2, by using a first-pass perfusion imaging approach.


RESULTS
The T2 quantification method yielded a hyperemic OEF of 0.37 +/- 0.05 and a hyperemic MVO2 of 9.2 +/- 2.4 micromol/g/min. The corresponding resting values were 0.73 +/- 0.05 and 5.2 +/- 1.7 micromol/g/min respectively, which agreed well with published literature values. The MVO2 rose proportionally with rate-pressure product from the rest condition. The T2 sensitivity is approximately 95% higher with the new T2 method than turbo-spin-echo method.


CONCLUSIONS
The CMR oxygenation method demonstrates the potential for non-invasive estimation of myocardial oxygenation, and should be explored in patients with altered myocardial oxygenation.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S, Kingshighway Blvd, St, Louis, MO 63110, USA.
Kyle S
KS
McCommis
Robert
R
O'Connor
Donna
D
Lesniak
Matt
M
Lyons
Pamela K
PK
Woodard
Robert J
RJ
Gropler
Jie
J
Zheng
D000241:Adenosine; D000328:Adult; D001794:Blood Pressure; D003326:Coronary Circulation; D005240:Feasibility Studies; D005260:Female; D006339:Heart Rate; D006801:Humans; D006940:Hyperemia / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption; D019047:Phantoms, Imaging; D011237:Predictive Value of Tests; D013997:Time Factors; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D000241:Adenosine; D010100:Oxygen