Molecular analysis of two novel Neisseria gonorrhoeae virulent components: the macrophage infectivity potentiator and the outer membrane protein A.
Molecular analyses of mip and ompA genes were performed on 20 Neisseria gonorrhoeae isolates. The genes were present with a high degree of conservation in all strains. Sera from patients with urethritis or disseminated gonococcal infections were able to recognize the purified Neisseria gonorrhoeae macrophage infectivity potentiator (Ng-MIP) and Neisseria gonorrhoeae outer membrane protein A (Ng-OmpA).
Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità Rome-Italy.
Stefania
S
Starnino
Rosanna
R
Leuzzi
Valeria
V
Ghisetti
Maria Antonia
MA
De Francesco
Marco
M
Cusini
Giampaolo
G
Impara
Emma
E
Galluppi
Mariagrazia
M
Pizza
Paola
P
Stefanelli
D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006069:Gonorrhea / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D017422:Sequence Analysis, DNA; D014526:Urethritis / Q000276:immunology / Q000382:microbiology; D037521:Virulence Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D011994:Recombinant Proteins; D037521:Virulence Factors; C078167:OMPA outer membrane proteins