Chronological changes in the systemic manifestations of intestinal Behcet's disease and their significance in diagnosis.
OBJECTIVE
Intestinal Behçet's disease (BD) is challenging to diagnose, especially if the patient presents with typical colonoscopic findings of intestinal BD without systemic manifestations of BD. We performed this study to evaluate the systemic manifestations of BD in patients with typical colonoscopic findings of intestinal BD at the time of initial presentation and to identity the chronologic changes of these features during an extended follow-up period.


METHODS
One hundred twenty-six consecutive patients who showed typical colonoscopic findings of intestinal BD at a single institution in Korea were enrolled. Clinical and endoscopic data were collected from a medical database and using a written questionnaire. Parameters including demographic characteristics and the subset type of BD at the initial and endpoints of the follow-up were analyzed.


RESULTS
The mean follow-up period was 63.9 ± 50.9 months. The number of cases that satisfied the International Study Group for Behçet's Disease criteria at initial diagnosis, 19.0%, increased to 53.2% by the end of follow-up. When the Japanese criteria were used for classification, the proportion of complete and incomplete type BD increased (2.4% and 26.2% to 18.3% and 49.2%, respectively), while that of suspected and not-satisfied subtype BD decreased (22.2% and 49.2% to 19.0% and 13.5%, respectively) during the follow-up period.


CONCLUSIONS
Our data suggest that patients who lack the systemic manifestations of BD could be included in the category of intestinal BD when typical intestinal lesion is identified, indicating that close examination and early treatment should be considered in such patients.
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-ku, Seoul, Korea.
Sung Jae
SJ
Shin
Sang Kil
SK
Lee
Tae Il
TI
Kim
Jae Hee
JH
Cheon
Eun Soo
ES
Kim
Byung Chang
BC
Kim
Sooyoung
S
Park
Won Ho
WH
Kim
D000328:Adult; D017677:Age Distribution; D001528:Behcet Syndrome / Q000145:classification / Q000175:diagnosis*; D003113:Colonoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007410:Intestinal Diseases / Q000145:classification / Q000175:diagnosis*; D008297:Male; D017060:Patient Satisfaction; D012727:Sex Characteristics; D013997:Time Factors