Nonhuman primate models of human immunology.
Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system.
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA. messaoud@ohsu.edu
Ilhem
I
Messaoudi
Ryan
R
Estep
Bridget
B
Robinson
Scott W
SW
Wong
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008253:Macaca mulatta / Q000276:immunology*; D023421:Models, Animal; D018448:Models, Immunological