[Study on the association between genetic polymorphism on WNK4 genes and essential hypertension among Kazakhs ethnic population, in Xinjiang].
OBJECTIVE
To investigate whether G1155942T polymorphism in WNK4 gene is associated with essential hypertension in a population with Kazakhs ethnicity, in Xinjiang.


METHODS
This study covered 563 hypertension patients and 346 normotensive controls. The variant of G1155942T was determined by the TaqMan probe real-time PCR method. Some biochemical indices such as glucose (GLU), triglyceride (TG) and total cholesterol (TC) were also measured. All of these results were under logistic regression analysis. Addictive model was applied to assess the interactive effects between WNK4 gene G1155942T mutation and environmental factors on hypertension.


RESULTS
The G1155942T polymorphism was consistent with Hardy-Weinberg expectations in both case and control groups. Genotype and allele frequencies of G1155942T were observed (P = 0.004, P = 0.003). Data through logistic regression analysis showed that factors as age, BMI, total cholesterol as well as the GT + TT genotype frequencies of Exon 8 G1155942T polymorphism in WNK4 were responsible for the increased risks for hypertension. Positive interactions between G1155942T mutation and gender, BMI, GLU, the OR were 3.75 (95%CI: 1.19 - 11.80), 5.77 (95%CI: 1.93 - 17.21) and 8.67 (95%CI: 1.03 - 72.99), respectively.


CONCLUSIONS
Our result suggested that the Exon 8 G1155942T polymorphism in WNK4 gene was associated with hypertension in the studied Kazakhs ethnic group in Xinjiang and the T allele might be the risk factor for essential hypertension. There were interactive effects between WNK4 gene G1155942T mutation, gender, BMI, and GLU.
Cao
Fei-fei
FF
Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.
Han
Hui
H
Wang
Fen
F
Chen
Xing-dong
XD
Lu
Ming
M
Wang
Xiao-feng
XF
Lin
Ren-yong
RY
Wen
Hao
H
Jin
Li
L
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors
D017346:Protein Serine-Threonine Kinases; C433806:WNK4 protein, human