[Evaluation of therapeutic effect in chronic obstructive pulmonary disease (COPD) by assessment of quality of life: methodological considerations].
Health status represents a tool frequently used for assessment of therapeutic impact of different therapeutic methods in various diseases including chronic obstructive pulmonary disease (COPD). We review the methodology of health status assessment performed with generic and disease or symptoms specific questionnaires Definition of quality of life-related terms, analysis of data from various studies on COPD using health status as an outcome measure was performed. Health status is widely used in studies assessing efficacy of both pharmacological and non-pharmacological therapeutic methods in COPD. In COPD health status can be measured with several generic or specific questionnaires and can be an appropriate efficacy endpoint in therapeutic trials.
Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi Facultatea de Medicină, Disciplina de Pneumologie.
Sabina Antonela
SA
Antoniu
Doina
D
Azoicăi
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D005938:Glucocorticoids / Q000627:therapeutic use; D006304:Health Status; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000188:drug therapy*; D011788:Quality of Life; D015203:Reproducibility of Results; D012647:Self-Assessment; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D000318:Adrenergic beta-Agonists; D018680:Cholinergic Antagonists; D005938:Glucocorticoids; D010726:Phosphodiesterase Inhibitors