Self-reported short sleep duration and frequent snoring in pregnancy: impact on glucose metabolism.
OBJECTIVE
We sought to evaluate the impact of short sleep duration (SSD) and frequent snoring (FS) on glucose metabolism during pregnancy.


METHODS
We conducted a prospective cohort study of healthy nulliparas who participated in a sleep survey study. SSD was defined as <7 hours of sleep per night and FS, as snoring >or=3 nights per week. Outcomes included 1-hour oral glucose tolerance results and the presence of gestational diabetes mellitus (GDM). Univariate and multivariate analyses were performed.


RESULTS
A total of 189 women participated; 48% reported an SSD and 18.5% reported FS. SSD and FS were associated with higher oral glucose tolerance values: SSD (116 +/- 31 vs 105 +/- 23; P = .008) and FS (118 +/- 34 vs 108 +/- 25; P = .04). Both SSD (10.2% vs 1.1%; P = .008) and FS (14.3% vs 3.3%; P = .009) were associated with a higher incidence of GDM. Even after controlling for potential confounders, SSD and FS remained associated with GDM.


CONCLUSIONS
SSD and FS are associated with glucose intolerance in pregnancy.
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. f-facco@md.northwestern.edu
Francesca L
FL
Facco
William A
WA
Grobman
Jamie
J
Kramer
Kim H
KH
Ho
Phyllis C
PC
Zee
D000328:Adult; D017677:Age Distribution; D001786:Blood Glucose / Q000032:analysis*; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D011296:Prenatal Diagnosis; D015995:Prevalence; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012650:Self Disclosure; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology*; D012913:Snoring / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
D001786:Blood Glucose; D005947:Glucose