PU.1 takes control of the dendritic cell lineage.
Despite the importance of the cytokine receptor flt3 in dendritic cell (DC) homeostasis, little is known about its regulation during DC development. In this issue of Immunity, Carotta et al. (2010) reveal that the transcription factor PU.1 controls Flt3 expression in hematopoietic progenitors in a dose-dependent manner.
Merad
Miriam
M
Department of Gene and Cell Medicine, The Tisch Cancer Institute and the Immunology Institute and Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10128, USA. miriam.merad@mssm.edu