Management of cryptococcal meningitis in sub-saharan Africa.
Cryptococcal meningitis (CM) is a common form of meningitis in sub-Saharan Africa due to the high prevalence of HIV/AIDS. This report outlines the management of CM with a focus on resource-limited settings. Sections covered include epidemiology and diagnosis, pharmacotherapy, management of complications, timing of antiretrovirals, and primary and secondary prevention of CM. Emphasis has been given to recent articles and landmark trials, and opinion is given from the authors' own experiences.
University of North Carolina Project, Kamuzu Central Hospital, 100 Mzimba Road, Private Bag A/104, Lilongwe, Malawi. arthurjackson@yahoo.com
Arthur
A
Jackson
Mina C
MC
Hosseinipour
D017954:Africa South of the Sahara / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003455:Cryptococcus neoformans / Q000187:drug effects; D003906:Developing Countries; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D006295:Health Resources; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000188:drug therapy; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic
D019380:Anti-HIV Agents; D000935:Antifungal Agents