Suppressive effect of Yamato-mana (Brassica rapa L. Oleifera Group) constituent 3-butenyl glucosinolate (gluconapin) on postprandial hypertriglyceridemia in mice.
We examined the bioactivity of Yamato-mana (Brassica rapa L. Oleifera Group) constituent glucosinolates and found that 3-butenyl glucosinolate (gluconapin) decreased the plasma triglyceride gain induced by corn oil administration to mice. However, phenethyl glucosinolate (gluconasturtiin) had little effect. 2-Propenyl glucosinolate (sinigrin) also reduced the plasma triglyceride level, which suggests that alkenyl glucosinolates might be promising agents to prevent postprandial hypertriglyceridemia.
Washida
Kazuto
K
Nara Prefectural Small and Medium-sized Enterprises Support Corporation, Nara Prefectural Agricultural Experiment Station, Kashihara, Nara, Japan. kwashida@festa.ocn.ac.jp
Miyata
Mitsuyoshi
M
Koyama
Tomoyuki
T
Yazawa
Kazunaga
K
Nomoto
Kyosuke
K
D000042:Absorption / Q000187:drug effects; D000818:Animals; D029741:Brassica rapa / Q000737:chemistry*; D005961:Glucosinolates / Q000494:pharmacology* / Q000627:therapeutic use; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000378:metabolism
C552436:3-butenyl glucosinolate; D005961:Glucosinolates; D010936:Plant Extracts; D014280:Triglycerides