The development of multiple cutaneous inverted papilloma following ovariohysterectomy in a dog.
METHODS
Ovariohysterectomy was performed on an adult Cavalier King Charles Spaniel. The skin that had been clipped for surgery was noticed to be erythematous 8 days later.


RESULTS
Poorly defined patches containing multiple papules were visible bilaterally within the clipped skin. These became larger over the following 2 weeks, and samples were collected for histology. Seven days later, the lesions were multiple raised masses, up to 5 cm in diameter. Histology revealed numerous cup-shaped epidermal proliferations extending into the dermis. The presence of keratinocytes with increased quantities of blue-grey cytoplasm, and koilocytosis suggested papillomaviral infection; Canis familiaris papillomavirus (CfPV-2) DNA was amplified from two separate samples. Complete regression was observed 8 weeks after the lesions had been initially observed.


METHODS
Multiple inverted papilloma confined to skin that had been clipped for surgery.


CONCLUSIONS
This is the first time that the development of canine cutaneous papillomas has been associated with surgery. The nature of the association between surgery and development of the papillomas is uncertain. However, it is possible that damage to superficial skin could promote the formation of papillomas. This is the first identification of CfPV-2 in New Zealand.
Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand. j.munday@massey.ac.nz
J S
JS
Munday
A F
AF
French
A R
AR
MacNamara
D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D007044:Hysterectomy / Q000009:adverse effects / Q000662:veterinary*; D010052:Ovariectomy / Q000009:adverse effects / Q000662:veterinary*; D018308:Papilloma, Inverted / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*