Use of lamotrigine in a patient with a clozapine-related seizure.
Seizures can be a serious adverse effect of clozapine, often a last-resort antipsychotic with unique efficacy for some patients. Several anticonvulsants have been reported to be useful in preventing further clozapine-induced seizures and permitting continued treatment with this medication. The authors describe the first reported successful use of lamotrigine for this purpose.
Muzyk
Andrew
A
Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA.
Gala
Gary
G
Kahn
David A
DA
D000927:Anticonvulsants / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D000077213:Lamotrigine; D016651:Lithium Carbonate / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy*; D014227:Triazines / Q000627:therapeutic use*; D055815:Young Adult
D000927:Anticonvulsants; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D014227:Triazines; D016651:Lithium Carbonate; D003024:Clozapine; D000077213:Lamotrigine