Leptin, adiponectin and resistin concentration in obesity class I and II at Sardjito Hospital Yogyakarta.
OBJECTIVE
to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population.


METHODS
cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m2 to <30 kg/m2) and obese class II (BMI >30 kg/m2). Leptin, adiponectin and resistin level concentration were measured.


RESULTS
leptin concentration in obese class I was 13.998 +/- 13.486 ng/ml; adiponectin was 3.98 +/- 1.78 microg/ml; resistin were 25.676 +/- 13.434 ng/ml. Leptin concentration in obese class II 31,074 +/- 26,158 ng/ml; adiponectin 4.75 +/- 1.88 microg/ml; resistin 25.46 +/- 12.26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.006)}. Adiponectin and resistin concentration was not significantly higher in obese class II than obese class I (p=0.156 and p=0.956).


CONCLUSIONS
leptin concentration in obese class II was significantly higher than in obese class I but adiponectin and resistin were not different.
Department of Internal Medicine, Faculty of Medicine, Gadjah Mada University - dr. Sardjito Hospital. Jl. Kesehatan Sekip no. 1, Yogyakarta. hemisinorita@yahoo.com
Hemi
H
Sinorita
Rizka H
RH
Asdie
R Bowo
RB
Pramono
Luthfan B
LB
Purnama
A H
AH
Asdie
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015994:Incidence; D007214:Indonesia / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D052243:Resistin / Q000097:blood*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D052243:Resistin