Severe epstein-barr virus encephalitis with hemophagocytic syndrome: rapid clearance of virus following allogeneic hematopoietic stem cell transplantation from a seropositive donor.
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with encephalitis is a life-threatening condition that requires treatment with immunochemotherapy; refractory patients are eligible for allogeneic hematopoietic stem cell transplantation. We report on an adolescent female who failed to respond to induction immunochemotherapy and was salvaged by allogeneic hematopoietic stem cell transplantation from her human leukocyte antigen-identical, Epstein-Barr virus-seropositive brother leading to rapid clearance of Epstein-Barr virus from blood and cerebrospinal fluid.
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. petra.sovinz@klinikum-graz.at
Petra
P
Sovinz
Wolfgang
W
Schwinger
Herwig
H
Lackner
Martin
M
Benesch
Andrea
A
Moser
Andrea
A
Raicht
Gerfried
G
Zobel
Christian
C
Urban
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D008279:Magnetic Resonance Imaging; D019562:Viral Load
D000914:Antibodies, Viral; D000956:Antigens, Viral