A novel synthesis of calix[4]thiophenes and calix[4]furans.
The addition of heteroaryllithium to various ketones followed by dehydration gave 1-(2-heteroaryl)cycloalkenes and (2-hetero- aryl)alkenes. When alkenes were treated with 10 mol% NIS, calix[4]thiophenes and calix[4]furans were obtained in good yields.
Department of Chemistry, Fu Jen Catholic University, Hsinchuang, Taipei 24205, Taiwan, Republic of China. 016850@mail.fju.edu.tw
Gon-Ann
GA
Lee
Wen-Chieh
WC
Wang
Minghuey
M
Shieh
Ting-Shen
TS
Kuo