One-pot synthesis of pyrimido[1,6-a]indol-1(2H)-one derivatives by a nucleophilic addition/Cu-catalyzed N-arylation/Pd-catalyzed C-H activation sequential process.
A novel and convenient one-pot synthesis of pyrimido[1,6-a]indol-1(2H)-one derivatives through a nucleophilic addition/Cu-catalyzed N-arylation/Pd-catalyzed C-H activation sequential process is described. The reaction of easily prepared ortho-gem-dibromovinyl isocyanates with N-alkyl-anilines gave the desired indole derivatives in moderate to good yields.
Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, PR China.
Zhi-Jing
ZJ
Wang
Jian-Guo
JG
Yang
Fan
F
Yang
Weiliang
W
Bao
D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007454:Iodides / Q000737:chemistry*; D017953:Isocyanates / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000814:Aniline Compounds; D007211:Indoles; D007454:Iodides; D017953:Isocyanates; D011743:Pyrimidines; C552166:pyrimido(1,6-a)indol-1(2H)-one; D010165:Palladium; D003300:Copper; C073870:cuprous iodide; C023650:aniline