Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).
Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.
Østergaard
Michael E
ME
Dept. of Chemistry, Univ. of Idaho, Moscow, ID-83844, USA.
Guenther
Dale C
DC
Kumar
Pawan
P
Baral
Bharat
B
Deobald
Lee
L
Paszczynski
Andrzej J
AJ
Sharma
Pawan K
PK
Hrdlicka
Patrick J
PJ
D015342:DNA Probes / Q000737:chemistry*; D003857:Deoxyuridine / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011721:Pyrenes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014230:Triazoles / Q000737:chemistry*
D015342:DNA Probes; D009841:Oligonucleotides; D011721:Pyrenes; D014230:Triazoles; D003857:Deoxyuridine