Mesenchymal stem cells immunosuppressive properties: is it specific to bone marrow-derived cells?
Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs have paracrine effects, including immunomodulation that occurs through the secretion of soluble mediators, including nitric oxide or interleukin-6, transforming growth factor-beta, human leukocyte antigen G5, and prostaglandin E2. MSCs in the bone marrow are in close contact with T and B cells and regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow. All of these biological effects are probably shared by all stromal cells, including fibroblasts and stem cells isolated from exfoliated deciduous teeth. The therapeutical implications are discussed.
Jorgensen
Christian
C
D001402:B-Lymphocytes / Q000276:immunology; D001854:Bone Marrow Cells / Q000276:immunology*; D015232:Dinoprostone / Q000378:metabolism; D059951:HLA-G Antigens / Q000378:metabolism; D006801:Humans; D007154:Immune System Diseases / Q000628:therapy; D007156:Immunologic Memory / Q000276:immunology; D056747:Immunomodulation / Q000276:immunology*; D015850:Interleukin-6 / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D009569:Nitric Oxide / Q000378:metabolism; D010950:Plasma Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000378:metabolism
D059951:HLA-G Antigens; C508600:IL6 protein, human; D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D009569:Nitric Oxide; D015232:Dinoprostone