Effects of aging on thermoregulatory responses and hormonal changes in humans during the four seasons in Japan.
Physiological functions are impaired in various organs in aged people, as manifest by, e.g., renal and cardiac dysfunction and muscle atrophy. The elderly are also at increased risk of both hypothermia and hyperthermia in extreme temperatures. The majority of those over 65 years old have elevated serum osmolality. Our hypothesis is that the elderly have suppressed osmolality control in different seasons compared to the young. Eight healthy young men and six healthy older men participated in this study. The experiments were performed during spring, summer, autumn and winter in Japan, with average atmospheric temperatures of 15-20°C in spring, 25-30°C in summer, 15-23°C in autumn and 5-10°C in winter. Each subject immersed his lower legs in warm water at 40°C for 30 min. Core (tympanic) temperature and sweat rate at chest were recorded continuously. Blood was taken pre-immersion to measure the concentrations of antidiuretic hormone, serum osmolality, plasma renin activity, angiotensin II, aldosterone, leptin, thyroid stimulating hormone, fT(3) and fT(4). The results suggested that the elderly have suppressed osmolality control compared to the young; osmolality was especially elevated in winter compared to the summer in elderly subjects. Therefore, particularly in the elderly, balancing fluid by drinking water should be encouraged to maintain euhydration status in winter.
Department of Physiology, Aichi Medical University, Nagakute, Aichi, 480-1195, Japan. msato@aichi-med-u.ac.jp
Maki
M
Sato
Dominika
D
Kanikowska
Junichi
J
Sugenoya
Yoko
Y
Inukai
Yuuki
Y
Shimizu
Naoki
N
Nishimura
Satoshi
S
Iwase
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D003198:Computer Simulation; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D014882:Water-Electrolyte Balance / Q000502:physiology*
D006728:Hormones