Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals.
OBJECTIVE
The relationship between variants of the leptin gene (LEP) and obesity and metabolic biomarkers was investigated in Brazilian individuals.


METHODS
One-hundred-ten obese (BMI > 30 kg/m(2)) and 100 non-obese individuals (145 women and 65 men, aged 49 +/- 14 years) were randomly selected. Plasma leptin, glycemia, serum lipid measurements and LEP -2548G>A and 3'HVR polymorphisms were analyzed.


RESULTS
The LEP -2548GG genotype was associated with a 2.2% and 2.0% increase in BMI (p = 0.009) and plasma leptin (p = 0.031), respectively. 3'HVR I/II (classes I/I+I/II) genotypes contributed with 1.8% of BMI values (p = 0.046). LEP I/G combined genotypes (I/IGG, I/IGA and I/IIGG) were associated with obesity, and increased BMI, waist circumference, leptin and triglycerides (p < 0.05). These relationships were found in women (p < 0.05) but not in men. LEP I/G combined genotypes were not associated with hypertension, hyperglycemia, dyslipidemia and coronary artery disease.


CONCLUSIONS
LEP I/G combined genotypes are associated with obesity-related metabolic biomarkers and phenotype in a gender-dependent manner.
USP, São Paulo, SP, Brasil.
Hamilton M
HM
Hinuy
Mario H
MH
Hirata
Marcelo F
MF
Sampaio
Dikran
D
Armaganijan
Simone Sorkin
SS
Arazi
Luis A
LA
Salazar
Rosario D C
RD
Hirata
D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001938:Brazil; D004812:Epidemiologic Methods; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D020738:Leptin / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics*
D015415:Biomarkers; D020738:Leptin