Integrated antimicrobial and nonfouling hydrogels to inhibit the growth of planktonic bacterial cells and keep the surface clean.
A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to inhibit the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.
Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.
Gang
G
Cheng
Hong
H
Xue
Guozhu
G
Li
Shaoyi
S
Jiang
D000327:Adsorption / Q000187:drug effects; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001622:Betaine / Q000737:chemistry; D048168:Escherichia coli K12 / Q000187:drug effects; D020100:Hydrogels / Q000737:chemistry*; D008962:Models, Theoretical; D010933:Plankton / Q000187:drug effects*; D011506:Proteins / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013499:Surface Properties
D000890:Anti-Infective Agents; D020100:Hydrogels; D011506:Proteins; D012459:Salicylates; D001622:Betaine