Gold(I)-catalyzed enantioselective polycyclization reactions.
A series of enantioselective polycyclization reactions, catalyzed by a cationic bisphosphine gold complexes, are described. The polycyclization reactions, which employ an alkyne as an initiating group, begin with a gold-promoted 6-exo-dig cyclization and can be terminated with a variety of nucleophiles including carboxylic acids, phenols, sulfonamides, and electron-rich aryl groups. This method allows for the preparation of up to four bonds in a single operation with excellent diastereo- and enantioselectivity.
Sethofer
Steven G
SG
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Mayer
Timo
T
Toste
F Dean
FD
D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism; D013379:Substrate Specificity
D006046:Gold