Interactions between PrP(c) and other ligands with the 37-kDa/67-kDa laminin receptor.
The 37-kDa/67 kDa laminin receptor (LRP/LR) represents a multifunctional protein. It is a receptor for viruses such as Dengue viruses, Alphaviruses and Adeno-associated viruses (AAV), as well as the cellular prion protein (PrPc) and infectious prions. Furthermore, the 37-kDa/67-kDa LRP/LR plays fundamental roles in basic cell biological processes such as cell adhesion and cell growth and acts as a key player in metastatic cancer, affecting invasion, adhesion and apoptotic processes. This review gives fundamental insights into basic cellular processes affected by LRP/LR including signal transduction and cell cycle progression and focuses on pathophysiological implications of the interaction of prion proteins, laminin, viruses and other ligands with LRP/LR affecting the development of highly-prevalent diseases such as cancer, neurodegenerative diseases such as prion disorders and Alzheimer's disease as well as viral infections. Molecular tools such as LRP/LR specific antibodies and siRNAs targeting LRP expression as possible alternative therapeutics for the treatment of neurodegenerative diseases, metastatic cancer and viral infections are emphasized.
Mbazima
Vusi
V
School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa (RSA).
Da Costa Dias
Bianca
B
Omar
Aadilah
A
Jovanovic
Katarina
K
Weiss
Stefan F T
SF
D002468:Cell Physiological Phenomena / Q000235:genetics / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008024:Ligands; D008970:Molecular Weight; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D018621:PrPC Proteins / Q000378:metabolism*; D011485:Protein Binding; D034622:RNA Interference; D017474:Receptors, Laminin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D008024:Ligands; D018621:PrPC Proteins; D017474:Receptors, Laminin