Saccadic preparation in the frontal eye field is modulated by distinct trial history effects as revealed by magnetoencephalography.
Optimizing outcomes involves rapidly and continuously adjusting behavior based on context. While most behavioral studies focus on immediate task conditions, responses to events are also influenced by recent history. We used magnetoencephalography and a saccadic paradigm to investigate the neural bases of 2 trial history effects that are well characterized in the behavioral eye movement literature: task-switching and the prior-antisaccade effect. We found that switched trials were associated with increased errors and transient increases in activity in the frontal eye field (FEF) and anterior cingulate cortex early in the preparatory period. These activity changes are consistent with active reconfiguration of the task set, a time-limited process that is triggered by the instructional cue. Following an antisaccade versus prosaccade, there was increased activity in the FEF and prefrontal cortex that persisted into the preparatory period of the subsequent trial, and saccadic latencies were prolonged. We attribute these effects to persistent inhibition of the ocular motor response system from the prior antisaccade. These findings refine our understanding of how trial history interacts with current task demands to adjust responses. Such dynamic modulations of neural activity and behavior by recent experience are at the heart of adaptive flexible behavior.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA.
Adrian K C
AK
Lee
Matti S
MS
Hämäläinen
Kara A
KA
Dyckman
Jason J S
JJ
Barton
Dara S
DS
Manoach
D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D003463:Cues; D004585:Electrooculography / Q000379:methods; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D012438:Saccades / Q000502:physiology*; D013997:Time Factors; D014794:Visual Fields / Q000502:physiology*