Mechanism of solvolysis of N-[2-(4-o-fluorophenylpiperazin-1-yl)ethyl]-2,5-dimethyl-1-phenylpyrrole-3,4-dicarboximide (PDI).
The stability of N-[2-(4-o-fluorophenylpiperazin-1-yl)ethyl]-2,5-dimethyl-1-phenylpyrrole-3,4-dicarboximide (PDI; a derivative with an analgesic activity) was studied in order to investigate its degradation mechanism and identify its degradation products in aqueous-organic solutions. The stability of PDI and its two degradation products (A and B) was performed with an HPLC method: (LiChrospher C18 column (250 x 4 mm LD., dp = 5 microm), mobile phase: 3.5 g/L solution of sodium lauryl sulfate and 1.6 mL of phosphoric acid(V)-acetonitrile (40:60, v/v), UV detector: 240 nm, flow rate: 1 ml/min). The identification of products A and B was conducted using HPLC-ES-MS and 1H- and 13C-NMR methods.
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland. asobczak@ump.edu.pl
Agnieszka
A
Sobczak
Marianna
M
Zajac
Wiesław
W
Malinka
Aleksandra
A
Redzicka
D000700:Analgesics / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical / Q000379:methods
D000700:Analgesics; C548176:N-(2-(4-o-fluorophenylpiperazin-1-yl)ethyl)-2,5-dimethyl-1 -phenylpyrrole-3,4-dicarboximide; D010879:Piperazines; D011758:Pyrroles; D012997:Solvents