How to train your biomarker.
Type I insulin-like growth factor (IGF) receptor (IGF1R) inhibitors are new cancer therapies. Pitts and colleagues used in vitro data to "train" a predictive biomarker for an IGF1R tyrosine kinase inhibitor. Given the complexity of IGF signaling, additional layers of biomarker analysis will likely be needed to develop predictive factors.
Yee
Douglas
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Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. yeexx006@umn.edu
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D020869:Gene Expression Profiling; D006801:Humans; D008024:Ligands; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D008024:Ligands; D047428:Protein Kinase Inhibitors; D017526:Receptor, IGF Type 1