Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies.
Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.
Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, United Kingdom.
Saiju
S
Jacob
Yusuf A
YA
Rajabally