New measles virus genotype associated with outbreak, China.
To determine the origin of the virus associated with a measles outbreak in Menglian County, Yunnan Province, People's Republic of China, in 2009, we conducted genetic analyses. Phylogenetic analyses based on nucleoprotein (N) and hemagglutinin (H) gene sequences showed that these Menglian viruses were not closely related to sequences of any World Health Organization (WHO) reference strains representing the 23 currently recognized genotypes. The minimum nucleotide divergence between the Menglian viruses and the most closely related reference strain, genotype D7, was 3.3% for the N gene and 3.0% for the H gene. A search of the databases of GenBank, WHO, and the Health Protection Agency Measles Nucleotide Surveillance showed that the Menglian viruses, together with the 2 older non-Menglian viruses, could be members of a new proposed measles genotype, d11. The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions.
Zhang
Yan
Y
National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.
Ding
Zhengrong
Z
Wang
Huiling
H
Li
Liqun
L
Pang
Yankun
Y
Brown
Kevin E
KE
Xu
Songtao
S
Zhu
Zhen
Z
Rota
Paul A
PA
Featherstone
David
D
Xu
Wenbo
W
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D014644:Genetic Variation; D006389:Hemagglutinins, Viral / Q000032:analysis / Q000235:genetics; D006801:Humans; D007223:Infant; D008457:Measles / Q000453:epidemiology / Q000821:virology; D008459:Measles virus / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000032:analysis / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D017423:Sequence Analysis, RNA; D014764:Viral Proteins / Q000032:analysis / Q000235:genetics
D006389:Hemagglutinins, Viral; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D012367:RNA, Viral; D014764:Viral Proteins; C058314:nucleoprotein, Measles virus