Y-box-binding protein-1 is a potential novel tumour marker for neuroblastoma.
BACKGROUND
The Y-box-binding protein-1 (YB-1) is a member of a family of DNA-binding proteins and an oncogenic transcription factor that is highly expressed in cancers of the breast, lung and prostate. To date, no data are available on its role in neuroblastoma. The aim of the present study was to evaluate the YB-1 expression in neuroblastoma.


METHODS
A tumour tissue microarray (TMA) was constructed from 36 neuroblastoma samples which were analysed by immunohistochemistry for YB-1 expression.


RESULTS
Expression of YB-1 was detected in 35 of 37 (94.6%) neuroblastoma cases examined. Nevertheless, no correlation of YB-1 expression with survival, risk factors or stage of the disease was observed.


CONCLUSIONS
As the majority of neuroblastomas express YB-1, this protein may play an important role in tumour pathogenesis. The results of this study suggest that YB-1 may serve as a novel immune marker for neuroblastoma and may be potentially useful as a therapeutic target.
Wachowiak
Robin
R
Department of Paediatric Surgery, University of Leipzig, Leipzig, Germany. robin.wachowiak@medizin.uni-leipzig.de
Thieltges
Sabrina
S
Rawnaq
Tamina
T
Kaifi
Jussuf T
JT
Fiegel
Henning
H
Metzger
Roman
R
Quaas
Alexander
A
Mertens
Peter R
PR
Till
Holger
H
Izbicki
Jakob R
JR
D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D046228:Microarray Analysis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis*; D012307:Risk Factors; D051840:Y-Box-Binding Protein 1
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human