Faecal CWD prion excretion and inflammation.
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE)--or prion disease (PD)--that has become of increasing concern throughout years among different captive and free-living deer species and populations in North America. Starting from the recent pre-clinical evidence of prion infectivity in faecal material from CWD-infected mule deer (Odocoileus hemionus), this contribution takes into special consideration the potential role of certain gut inflammatory conditions as a factor modulating the infectivity titres and, consequently, also the CWD prion faecal excretion rate.
Di Guardo
Giovanni
G
University of Teramo, Faculty of Veterinary Medicine, Department of Comparative Biomedical Sciences, Teramo, Italy. gdiguardo@unite.it
Marruchella
Giuseppe
G
D000818:Animals; D000835:Animals, Wild; D003670:Deer / Q000378:metabolism*; D005243:Feces / Q000737:chemistry*; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000503:physiopathology; D007249:Inflammation / Q000276:immunology*; D018620:PrPSc Proteins / Q000378:metabolism* / Q000472:pathogenicity; D017096:Prion Diseases / Q000378:metabolism* / Q000635:transmission / Q000662:veterinary; D034081:Wasting Disease, Chronic / Q000276:immunology / Q000378:metabolism* / Q000635:transmission
D018620:PrPSc Proteins