Enantioselective total synthesis of the selective PI3 kinase inhibitor liphagal.
The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K α isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic "liphagane" skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.
Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, 18071 Granada, Spain. eamr@ugr.es
Enrique
E
Alvarez-Manzaneda
Rachid
R
Chahboun
Esteban
E
Alvarez
Ma José
MJ
Cano
Ali
A
Haidour
Ramón
R
Alvarez-Manzaneda
D015394:Molecular Structure; D000081082:Phosphoinositide-3 Kinase Inhibitors; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis*
D000081082:Phosphoinositide-3 Kinase Inhibitors; D013729:Terpenes; C513880:liphagal