Evaluation of anti-GERD activity of gastro retentive drug delivery system of itopride hydrochloride.
The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO(3)) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form.
University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Orissa, India.
Trilochan
T
Satapathy
Prasana K
PK
Panda
Amit K
AK
Goyal
Goutam
G
Rath
D000464:Alginates / Q000737:chemistry; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D001593:Benzyl Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D005750:Gastric Juice / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000187:drug effects; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D008297:Male; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000188:drug therapy
D000464:Alginates; D001549:Benzamides; D001593:Benzyl Compounds; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D020100:Hydrogels; C102254:itopride; D020723:Glucuronic Acid; D002119:Calcium Carbonate