Reibergram of intrathecal synthesis of C4 in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Angiostrongylus cantonensis produces eosinophilic meningitis in humans and is endemic in Thailand, Taiwan, China, and the Caribbean region. During infection with this parasite, it is important to know if the complement system may be activated by the classical or lectin pathway. Cerebrospinal fluid and serum samples from 20 patients with meningitic angiostrongyliasis were used to quantify C4 levels and albumin. Results were plotted on a C4 CSF/serum quotient diagram or Reibergram. Twelve patients showed intrathecal synthesis of C4. Antibody-dependent complement cytotoxicity should be considered as a possible mechanism that destroys third-stage larvae of this helminth in cerebrospinal fluid of affected patients.
Padilla-Docal
Bárbara
B
Central Laboratory of Cerebrospinal Fluid, Faculty of Medical Sciences Dr. Miguel Enriquez, Havana Medical Sciences University, Havana, Cuba.
Dorta-Contreras
Alberto Juan
AJ
Bu-Coifiu-Fanego
Raisa
R
Rodríguez-Rey
Alexis
A
Gutiérrez-Hernández
Juan Carlos
JC
de Paula-Almeida
Susana Olga
SO
D000293:Adolescent; D000328:Adult; D017185:Angiostrongylus cantonensis; D000818:Animals; D000909:Antibodies, Helminth; D002648:Child; D002675:Child, Preschool; D003181:Complement C4 / Q000134:cerebrospinal fluid* / Q000378:metabolism; D004802:Eosinophilia / Q000097:blood / Q000134:cerebrospinal fluid / Q000469:parasitology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000469:parasitology*; D017206:Strongylida Infections / Q000097:blood / Q000134:cerebrospinal fluid*; D055815:Young Adult
D000909:Antibodies, Helminth; D003181:Complement C4