Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant.
Recently, a new genus of Anaplasmataceae termed "Candidatus Neoehrlichia" was discovered in ticks and rodents. Here, we report on two patients who suffered from febrile bacteremia due to "Candidatus Neoehrlichia mikurensis" associated with thrombotic or hemorrhagic events. 16S rRNA and groEL gene sequencing provided evidence of three groups of sequence variants.
Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
Friederike D
FD
von Loewenich
Walter
W
Geissdörfer
Claudia
C
Disqué
Jens
J
Matten
Georg
G
Schett
Samir G
SG
Sakka
Christian
C
Bogdan
D000368:Aged; D000710:Anaplasmataceae / Q000235:genetics / Q000302:isolation & purification*; D000711:Anaplasmataceae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D001853:Bone Marrow / Q000382:microbiology; D004269:DNA, Bacterial / Q000737:chemistry; D005060:Europe; D017809:Fatal Outcome; D005334:Fever / Q000382:microbiology*; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D017282:Tick-Borne Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S