Research and synthesis of organosilicon nonthrombogenic materials containing sulfobetaine group.
A novel organosilicon sulfobetaine was synthesized through the reaction of organosilicon containing tertiary amino with 1,3-propanesulfone. Then this organosilicon sulfobetaine was coated onto polyurethane and organosilicon surface to improve their blood compatibility. The existence of sulfobetaine structure on the surface of materials was revealed by ATR-FTIR and XPS. The thermo-capability of synthesized silicone rubber, containing sulfobetaine was revealed by TGA. The blood compatibilities of organosilicon sulfobetaine and other materials such as silicone and PU as reference coated with them were evaluated by platelet-rich plasma adhesion experiment. The novel segmented silicone rubber containing sulfobetaine structure showed perfect blood compatibility.
Chemical Engineering College, Nanjing Forest University, Nanjing 210037, China. dmin@ncsu.edu
Dou yong
Dy
Min
Zhong zheng
Zz
Li
Jian
J
Shen
Si cong
Sc
Lin
D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D017646:Organosilicon Compounds / Q000138:chemical synthesis*; D056951:Photoelectron Spectroscopy; D053657:Platelet-Rich Plasma / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013927:Thrombosis / Q000517:prevention & control*; D013997:Time Factors
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D017646:Organosilicon Compounds; D001622:Betaine; C483727:sulfobetaine