Signal-processing characteristics of differential-interference-contrast microscopy. 2: Noise considerations in signal recovery.
A mathematical model and computer simulation, presented in a previous publication, of the optics of differential-interference-contrast (DIC) microscopy (DICM) is extended to consider the effects of stochastic noise. Images resulting from this simulation indicate that, even in the presence of a significant level of noise, the resolution and detail of objects can be much improved with a proposed image-restoration algorithm. Thus the feasibility of superresolution with DICM in the presence of noise is supported.
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Holmes