Frequencies of specific peptides in intrinsic disordered protein domains.
We evaluated the i-peptides occurrence frequency in the protein sequences, belonging to two reference datasets containing structured and disordered protein domains. Moreover we estimated the most frequent i-peptides (with i= 2, 3, 4) into these sequences in order to select specific i-peptides for each structural classification. According to these specific i-peptides, a new binary classification method was developed for predicting if a given protein sequence can be classified as "disordered" or "structured". The best results were obtained using the tri-peptides, much more able to gain structural information from sequences compared to the di-peptides.
Costantini
Susan
S
Centro Ricerche Oncologiche di Mercogliano "Fiorentino Lo Vuolo", via Ammiraglio Bianco, 83013 Mercogliano (AV) Italy. susan.costantini@unina2.it
Costantini
Maria
M
Colonna
Giovanni
G
D000465:Algorithms; D000595:Amino Acid Sequence; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D009842:Oligopeptides / Q000737:chemistry*; D010363:Pattern Recognition, Automated / Q000379:methods; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012984:Software
D009842:Oligopeptides; D011506:Proteins