HAT trick: p300, small molecule, inhibitor.
p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico screen for active site small molecule inhibitors of p300. We describe this important discovery and its potential therapeutic applications.
Ott
Melanie
M
Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, 1650 Owens St., San Francisco, CA 94158, USA. mott@gladstone.ucsf.edu
Verdin
Eric
E