Castleman's disease presenting with uveal effusion syndrome.
We report a rare case of multicentric Castleman's disease that presented with ophthalmic involvement, along with a review of the literature. A 63-year-old male presented with decreased visual acuity in both eyes. Both eyes had serous elevations of the retinas with shifting subretinal fluid and annular choroidal detachment. No retinal breaks were found. Laboratory tests revealed pancytopenia, hypergammaglobulinemia, and an increased erythrocyte sedimentation rate. Chest and abdominal computed tomographies showed multiple lymphadenopathies in the mediastinum, abdomen, and in both inguinal areas. Histological examination of the inguinal lymph node biopsy was consistent with Castleman's disease. After combination chemotherapy, the serous elevations of both retinas and the annular choroidal detachments of both eyes disappeared. Ophthalmic involvement in Castleman's disease is very rare, and to the authors' knowledge, this is the first report of ophthalmic involvement of Castleman's disease in Korea.
Park
Sang Hoon
SH
Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, #108 Pyeong-dong, Jongno-gu, Seoul, Korea.
Song
Su Jeong
SJ
D000368:Aged; D005871:Castleman Disease / Q000150:complications* / Q000188:drug therapy; D015862:Choroid Diseases / Q000209:etiology; D004359:Drug Therapy, Combination; D005122:Exudates and Transudates / Q000378:metabolism*; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D013577:Syndrome; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014603:Uveal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*