Potency of anidulafungin compared to nine other antifungal agents tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: results from the global SENTRY Antimicrobial Surveillance Program (2008).
The SENTRY Antimicrobial Surveillance Program regularly monitors global susceptibility rates for a spectrum of both novel and established antifungal agents. Anidulafungin and the other echinocandins displayed sustained, excellent activity against Candida spp. and Aspergillus fumigatus, with >or=98% of MIC results at <or=2 microg/ml. Six yeast isolates (all Candida glabrata) showing caspofungin MIC values of >or=0.5 microg/ml were further analyzed for potential fks hot spot (HS) mutations; three isolates had confirmed mutations in the fks1 HS1 region (S645P), and three exhibited mutations in the fks2 HS1 region (S645F and S645P).
JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA. sam-messer@jmilabs.com
Shawn A
SA
Messer
Ronald N
RN
Jones
Gary J
GJ
Moet
Jeffrey T
JT
Kirby
Mariana
M
Castanheira
D019943:Amino Acid Substitution / Q000235:genetics; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000302:isolation & purification; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D003454:Cryptococcus / Q000187:drug effects* / Q000302:isolation & purification; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D020125:Mutation, Missense
D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D000077612:Anidulafungin