Osteomalacia as a result of vitamin D deficiency.
Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was commonly caused by malabsorption, nutritional deficiency now is more common. In addition, recent literature suggests that nutritional vitamin D deficiency osteomalacia follows various bariatric surgeries for morbid obesity. Bone pain, tenderness, muscle weakness, and difficulty walking are all common clinical manifestations of osteomalacia. Diagnostic work-up involves biochemical assessment of vitamin D status and may also include a transiliac bone biopsy. Treatment is based on aggressive vitamin D repletion in most cases with follow-up biopsies if patients are started on antiresorptive or anabolic agents.
Bhan
Arti
A
Division of Endocrinology, Diabetes and Bone & Mineral Disorders, Henry Ford Hospital, Detroit, MI 48202, USA.
Rao
Ajay D
AD
Rao
D Sudhaker
DS
D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery / Q000009:adverse effects; D002648:Child; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D051346:Mobility Limitation; D018908:Muscle Weakness / Q000178:diet therapy / Q000378:metabolism / Q000473:pathology; D009767:Obesity, Morbid / Q000601:surgery; D010018:Osteomalacia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D014807:Vitamin D / Q000032:analysis / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications*; D055815:Young Adult
D014807:Vitamin D