Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
OBJECTIVE
The assessment of the clinical significance of creatine, cytosine, cytidine, uridine, thymine, thymidine, and 2'-deoxyuridine concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between pyrimidine metabolites and disease.


METHODS
The study group consisted of 119 subjects, which were divided to three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23), and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants.


RESULTS
There is a significant increase in levels of cytosine (P<0.001), cytidine (P<0.001), and thymidine (P=0.016) with DN compared to DM. The levels of uridine, thymine, 2'-deoxyuridine, and creatine did not change.


CONCLUSIONS
The levels of cytosine, cytidine, and thymidine may be useful for monitoring the progression of DM and evaluating the treatment.
School of Pharmaceutics, East-China University of Science and Technology, Shanghai, PR China.
Jian-Fei
JF
Xia
Ping
P
Hu
Qiong-Lin
QL
Liang
Ting-Ting
TT
Zou
Yi-Ming
YM
Wang
Guo-An
GA
Luo
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003401:Creatine / Q000097:blood*; D003562:Cytidine / Q000097:blood; D003596:Cytosine / Q000097:blood; D003857:Deoxyuridine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000097:blood*; D053719:Tandem Mass Spectrometry; D013936:Thymidine / Q000097:blood; D013941:Thymine / Q000097:blood; D014529:Uridine / Q000097:blood
D011743:Pyrimidines; D003562:Cytidine; D003596:Cytosine; C030986:pyrimidine; D003401:Creatine; D013941:Thymine; D013936:Thymidine; D003857:Deoxyuridine; D014529:Uridine