HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.
Kozikowski
Alan P
AP
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612-7230, USA. kozikowa@uic.edu
Cho
Sung Jin
SJ
Jensen
Niels H
NH
Allen
John A
JA
Svennebring
Andreas M
AM
Roth
Bryan L
BL
D000818:Animals; D002460:Cell Line; D002986:Clinical Trials as Topic; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D057166:High-Throughput Screening Assays; D006801:Humans; D008024:Ligands; D008744:Methylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D010622:Phencyclidine / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D044403:Receptor, Serotonin, 5-HT2B / Q000378:metabolism; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy*; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D003521:Cyclopropanes; D008024:Ligands; D008744:Methylamines; D044402:Receptor, Serotonin, 5-HT2A; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D010622:Phencyclidine