HIV-2 capsids distinguish high and low virus load patients in a West African community cohort.
HIV-2 causes AIDS similar to HIV-1, however a considerable proportion of HIV-2 infected patients show no disease and have low plasma virus load (VL). An analysis of HIV-2 capsid (p26) variation demonstrated that proline at p26 positions 119, 159 and 178 are more frequent in lower VL subjects while non-proline residues at all three sites are more frequent in subjects with high VL. In vitro replication levels of viruses bearing changes at the three sites suggested that these three residues influence virus replication by altering susceptibility to TRIM5alpha. These results provide new insights into HIV-2 pathogenesis.
Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia. conyango@mrc.gm
Clayton O
CO
Onyango
Aleksandra
A
Leligdowicz
Masaru
M
Yokoyama
Hironori
H
Sato
Haihan
H
Song
Emi E
EE
Nakayama
Tatsuo
T
Shioda
Thushan
T
de Silva
John
J
Townend
Assan
A
Jaye
Hilton
H
Whittle
Sarah
S
Rowland-Jones
Matthew
M
Cotten
D000090103:Antiviral Restriction Factors; D002213:Capsid / Q000821:virology*; D002352:Carrier Proteins / Q000378:metabolism; D015331:Cohort Studies; D006169:Guinea-Bissau; D015658:HIV Infections / Q000821:virology*; D015498:HIV-2 / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000235:genetics; D020539:Sequence Analysis, Protein; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D019562:Viral Load; D014779:Virus Replication; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism
D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D012367:RNA, Viral; D000070584:Tripartite Motif Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C065558:gag protein p26, Human immunodeficiency virus; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases