Association of longevity with IL-10 -1082 G/A and TNF-alpha-308 G/A polymorphisms.
Cytokines are crucial for the regulation of inflammation development in humans. Many studies have shown that variations in cytokine genes might play a role in determining human longevity. This study examined the changes in the gene pool relevant to the -308 G/A polymorphism in the promoter region of the proinflammatory cytokine tumour necrosis factor (TNF)-alpha gene and the -1082 G/A polymorphism in the promoter region of anti-inflammatory cytokine interleukin (IL)-10 gene with aging and survival selection occurs in the Jordanian population. IL-10 -1028 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years. No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05) while the IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05). Thus, IL-10 -1028 G/A polymorphism seems to play a role in the pathway to longevity in Jordanian men.
Khabour
O F
OF
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan. khabour@just.edu.jo
Barnawi
J M
JM
D000328:Adult; D000369:Aged, 80 and over; D000483:Alleles; D018912:Arabs / Q000235:genetics* / Q000706:statistics & numerical data; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics* / Q000502:physiology; D007597:Jordan / Q000453:epidemiology; D008136:Longevity / Q000235:genetics* / Q000276:immunology; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012494:Sampling Studies; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000502:physiology
C508609:IL10 protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10