Alpha,beta-D-CNA preorganization of unpaired loop moiety stabilizes DNA hairpin.
DNA hairpin structures can be stabilized by introduction of constraint on the sugar phosphate backbone within the unpaired loop moiety by means of dinucleotides locked with an alpha torsion angle in gauche(+) configuration.
Dupouy
Christelle
C
Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, UMR 5068 CNRS, Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse Cedex 9, France.
Millard
Pierre
P
Boissonnet
Arnaud
A
Escudier
Jean-Marc
JM
D001483:Base Sequence; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D055029:Inverted Repeat Sequences; D008968:Molecular Conformation; D044366:Transition Temperature
D004247:DNA