Enantioselective synthesis of (R)-bufuralol via dynamic kinetic resolution in the key step.
An enantioselective synthesis of (R)-bufuralol via a ruthenium- and enzyme-catalyzed dynamic kinetic resolution (DKR) has been achieved. The synthesis starts from readily available 2-ethylphenol and provides (R)-bufuralol in high ee and a good overall yield of 31%.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Eric V
EV
Johnston
Krisztián
K
Bogár
Jan-E
JE
Bäckvall
D002384:Catalysis; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D004983:Ethanolamines; D010636:Phenols; C495777:2-ethylphenol; D012428:Ruthenium; C010831:bufuralol; D008049:Lipase