Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms.
Vitamin D is essential for optimal bone health. Stress fracture is an overuse injury often occurring in active populations. Study results indicate an association exists between vitamin D status and the risk of stress fracture, and one intervention trial demonstrated a reduction in stress fractures in women consuming supplemental vitamin D and calcium. A recent study found that two polymorphisms in the vitamin D receptor (VDR), Fok1 and Bsm1, may increase the risk of stress fracture. Although further study is required, screening for VDR polymorphisms may become a tool for identifying individuals at increased risk of stress fracture during physical training.
Military Nutrition Division of the US Army Research Institute of Environmental Medicine (USARIEM), Natick, Massachusetts 01760, USA. James.McClung@amedd.army.mil
James P
JP
McClung
J Philip
JP
Karl
D005260:Female; D015775:Fractures, Stress / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008297:Male; D009752:Nutritional Status; D010809:Physical Fitness; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D014807:Vitamin D / Q000502:physiology*
D018167:Receptors, Calcitriol; D014807:Vitamin D