Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management.
OBJECTIVE
To establish the relationship between the functional impairment experienced by Chronic fatigue syndrome (CFS) patients and the symptoms frequently experienced by those with CFS; specifically cognitive impairment, fatigue and orthostatic symptoms.


METHODS
Cross sectional questionnaire survey.


METHODS
Specialist CFS Clinical Service.


METHODS
Ninety-nine Fukuda diagnosed CFS and 64-matched controls.


METHODS
Symptom and functional assessment tools completed and returned by post included; PROMIS HAQ (Patient-Reported Outcomes Measurement Information System, Health Assessment Questionnaire), CFQ (Cognitive Failures Questionnaire), FIS (Fatigue Impact Scale) and OGS (Orthostatic Grading Scale) assessment tools.


RESULTS
CFS patients experience greater functional impairment than controls [mean (95% CI) PROMIS HAQ scores CFS 36 (31-42) vs. controls 6 (2-10); P < 0.0001], especially in the functional domains of activities and reach. Poorer functional ability impairment is significantly associated with greater cognitive impairment (P = 0.0002, r = 0.4), fatigue (P < 0.0001, r = 0.5) and orthostatic symptoms (P < 0.0001, r = 0.6). However, only orthostatic symptoms (OGS) independently associated with functional impairment (beta = 0.4, P = 0.01).


CONCLUSIONS
Treatment of orthostatic symptoms in CFS has the potential to improve functional capacity and so improve quality of life.
NIHR Biomedical Research Centre in Ageing-Cardiovascular Theme, Newcastle University, Newcastle, UK.
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Costigan
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Elliott
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McDonald
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Newton
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004244:Dizziness / Q000209:etiology*; D015673:Fatigue Syndrome, Chronic / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D006113:United Kingdom