A three-year-analysis of fixed drug eruptions in hospital settings in France.
Fixed drug eruption (FDE) is one of the most typical cutaneous drug adverse reactions. This localized drug-induced reaction is characterized by its relapse at the same sites. Few large series of FDE are reported. The aim of this study was to retrospectively collect and analyse well informed cases observed in a hospital setting. This study involved 17 academic clinical centers. A French nation-wide retrospective multicentric study was carried out on a 3-year-period from 2005 to 2007 by collecting data in seventeen departments of dermatology in France. Diagnosis of FDE was based essentially on clinical findings, at times confirmed by pathological data and patch-testing. Records were reviewed for demographics, causative drugs, localization, severity, and patch-tests, when available. Fifty nine cases were analysed. Patients were 59-years-old on average, with a female predilection. The most common drug was paracetamol, followed by the non-steroidal anti inflammatory drugs. The time between drug intake and skin symptoms was, on average, two days. Beside these classical characteristics, some original findings were found including, a frequent non pigmentation course and a sex-dependent pattern of distribution. Women often had lesions on the hands and feet, and men on the genitalia. Given the fact that skin pigmentation is an inconstant feature of FDE, its French name (erythème pigmenté fixe) should be reconsidered. The sex-dependent distribution could help our understanding of the pathophysiology of fixed drug eruption.
Brahimi
Nesrine
N
Department of Dermatology, Bichat Hospital, APHP, 46 rue Henri-Huchard, 75877 Paris, France.
Routier
Emilie
E
Raison-Peyron
Nadia
N
Tronquoy
Anne-Fleur
AF
Pouget-Jasson
Caroline
C
Amarger
Stéphanie
S
Machet
Laurent
L
Amsler
Emmanuelle
E
Claeys
Antoine
A
Sassolas
Bruno
B
Leroy
Dominique
D
Grange
Anne
A
Dupuy
Alain
A
Cordel
Nadège
N
Bonnetblanc
Jean-Marie
JM
Milpied
Brigitte
B
Doutre
Marie-Sylvie
MS
Guinnepain
Marie-Thérèse
MT
Barbaud
Annick
A
Chosidow
Olivier
O
Roujeau
Jean-Claude
JC
Lebrun-Vignes
Bénédicte
B
Descamps
Vincent
V
D000082:Acetaminophen / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000009:adverse effects; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002648:Child; D003875:Drug Eruptions / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012189:Retrospective Studies
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen