CD44-ligation induces, through ERK1/2 pathway, synthesis of cytokines TNF-alpha and IL-6 required for differentiation of THP-1 monoblastic leukemia cells.
S
S
Bourcier
A
A
Sansonetti
L
L
Durand
C
C
Chomienne
J
J
Robert-Lézénés
F
F
Smadja-Joffe
D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D007948:Leukemia, Monocytic, Acute / Q000378:metabolism / Q000473:pathology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3