Surgical antibiotic prophylaxis after renal transplantation: time to reconsider.
The optimal regimen for perioperative antibiotic prophylaxis after renal transplantation remains to be determined. Worldwide, it seems there is a trend toward decreased use of prophylaxis from the first 48 hours to several days after surgery. However, bacterial strains resistant to common antibiotic agents arise even if only a single dose of a molecule is administered at any time. Inasmuch as infections currently are the primary cause of hospitalization after renal transplantation, it is desirable to not favor selection of resistant strains that may not be treated appropriately in the event of onset of infection. Therefore, antibiotic therapy, whether for therapeutic or prophylactic purposes, should be administered based exclusively on clinical evidence. Because systemic antibiotic prophylaxis is not effective against infections of the urinary tract, the objective of perioperative antibiotic prophylaxis should be to prevent infection of the surgical wound. In this case, administration of a single dose of an antibiotic agent (1-shot regimen) at the induction of anesthesia is effective and safe. For these reasons, it is urgent that new guidelines be defined for perioperative antibiotic prophylaxis. Multicenter prospective randomized trials comparing 1-shot vs multiple-dose regimens should be performed to establish the optimal regimen.
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, England. gorlando@wfubmc.edu
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G
Orlando
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Di Cocco
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D'Angelo
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K
Clemente
T M
TM
Manzia
R
R
Angelico
G
G
Tisone
J
J
Romagnoli
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F
Citterio
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A
Famulari
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Pisani
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D012449:Safety; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents