Early uptake and continuous accumulation of thallium-201 chloride in a benign mixed tumor of soft tissue: case report.
A case of benign mixed tumor of the soft tissue in a 64-year-old Japanese male is presented. He noticed a painless, elastic hard mass sized 3 cm in the right knee, which gradually grew larger and harder in the last 5 years. Magnetic resonance imaging demonstrated a mass lesion embedded in the subcutaneous tissue with low and high signal intensity at T1- and T2-weighted images, respectively. Tl-201 scintigraphy showed an early uptake of Tl-201 within the lesion at 10 minutes after injection, which was slightly decreased but still continued at 2 hours later. The patient underwent a resection of tumor, and the pathological diagnosis was a benign mixed tumor of soft tissue without high vascularity, characterized by histological features similar to pleomorphic adenomas in the salivary glands. Immunohistochemical study proved expression of Na+/K+-ATPase of tumor cells. Overexpression of Na+/K+-ATPase of the tumor might be responsible for the early uptake of Tl-201, and poor vascular structure in this tumor might lead to continuous accumulation. The Tl-201 scintigraphic features of mixed tumor of soft tissue are assessed to resemble those of malignant soft tissue tumors.
Nagata
Shigenori
S
Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka 537-8511, Japan.
Jin
Yu-Fen
YF
Yoshizato
Katsuhiko
K
Kitamura
Masanori
M
Iizuka
Norishige
N
Song
Misa
M
Tomoeda
Miki
M
Yuki
Michiko
M
Kubo
Chiaki
C
Yoshizawa
Hidenori
H
Outani
Hidetatsu
H
Hamada
Kenichiro
K
Araki
Nobuhito
N
Funauchi
Masahiro
M
Tomita
Yasuhiko
Y
D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D007717:Knee; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000601:surgery; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000601:surgery; D013793:Thallium / Q000378:metabolism; D014055:Tomography, Emission-Computed; D051598:Whole Body Imaging
D019275:Radiopharmaceuticals; C027549:thallium chloride; D013793:Thallium; D000254:Sodium-Potassium-Exchanging ATPase