Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats.
Zanthoxylum armatum DC (Rutaceae) is extensively used in indigenous system of medicine as a tonic, carminative, stomachic and anthelmintic. In the present study, the hepatoprotective activity of the leaves ethanolic extract of Z. armatum (EEZA) was evaluated in CCl4-induced hepatotoxicity in rats. The extract at a dose of 500 mg/kg registered a significant decrease in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), and serum bilurubin (SBLN) and liver inflammation, which was supported by histopathological studies on liver, thus exhibited a significant hepatoprotective activity. The phytochemical screening of defatted ethanolic extract showed the presence of sterols, alkaloids, flavonoids, and reducing sugars.
Department of Pharmacy, Bharat Institute of Technology, Bye-Pass Road, Partapur Meerut 250 103 (U.P.), India. nitinmiet14@rediffmail.com
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D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D000431:Ethanol / Q000737:chemistry; D005260:Female; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D032106:Zanthoxylum / Q000737:chemistry*
D010936:Plant Extracts; D000431:Ethanol; D002251:Carbon Tetrachloride