Langerhans cell histiocytosis with digestive tract involvement.
Gastrointestinal tract (GIT) involvement in Langerhans cell histiocytosis (LCH) is not commonly described. We present two children presenting with GIT involvement with LCH, one successfully treated on standard protocol and other being treated on a protocol for relapsed disease. A review of literature showed almost 95% children were less than 2 years of age and 62% were females. Vomiting, abdominal pain, constipation, intractable diarrhea, malabsorption, bloody stools, protein-losing enteropathy, and even intestinal perforation are some of the reported symptoms. More than 50% patients died within 18 months from diagnosis.
Yadav
Satya P
SP
Pediatric Haematology and Oncology and Bone Marrow Transplantation Unit, Department of Pediatrics, Center for Child Health, Sir Ganga Ram Hospital, Delhi, India. satya 1026@hotmail.com
Kharya
Gaurav
G
Mohan
Neelam
N
Sehgal
Anupam
A
Bhat
Sunil
S
Jain
Sandeep
S
Kapoor
Gauri
G
Sachdeva
Anupam
A
D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D016896:Treatment Outcome