The loss of 8p23.3 is a novel marker for predicting progression and recurrence of bladder tumors without muscle invasion.
There are few reliable markers to distinguish tumors with aggressive characteristics from others at the time of initial diagnosis in non-muscle-invasive bladder cancer. The purpose of this study was to identify a genomic marker that allows the prediction of prognosis for non-muscle-invasive bladder cancers. We screened the genome-wide copy number in 41 patients with non-muscle-invasive urothelial carcinoma of the bladder by array-based comparative genomic hybridization using arrays spotted with 4,030 bacterial artificial chromosome clones. A loss of 8p23.3 (clone 923) was correlated significantly with a higher histological grade (P = 0.0026) and advanced pathological stage (P = 0.0148). Both recurrence-free and progression-free survival rates were lower in patients with tumors without 8p23.3, compared with those with 8p23.3 (P = 0.0146 and 0.0473, respectively; log-rank test). These data suggest that the loss of 8p23.3 is a novel genomic marker allowing estimation of biological characteristics of non-muscle-invasive bladder cancer.
Department of Urology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Satoshi
S
Eguchi
Yoshiaki
Y
Yamamoto
Shigeru
S
Sakano
Yasuyo
Y
Chochi
Motonao
M
Nakao
Shigeto
S
Kawauchi
Tomoko
T
Furuya
Atsunori
A
Oga
Hideyasu
H
Matsuyama
Kohsuke
K
Sasaki
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002898:Chromosomes, Human, Pair 8; D055028:Comparative Genomic Hybridization; D018450:Disease Progression; D005260:Female; D018628:Gene Dosage; D005819:Genetic Markers; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
D005819:Genetic Markers