Keeping one's option open.
In the periphery, T helper cell differentiation is a key event orchestrating the adaptive immune response yet recent studies demonstrate considerable plasticity in these cell fate decisions. In this issue of Immunity, Mukasa et al. (2010) describe the epigenetic basis underlying this plasticity.
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Patrick L
PL
Collins
Thomas M
TM
Aune