Asymmetric PPCys: strongly fluorescing NIR labels.
By a stepwise synthesis strategy biofunctionalized Pyrrolopyrrole Cyanines (PPCy) with an asymmetric substitution pattern were obtained. These exhibit extremely strong and narrowband NIR absorption and fluorescence. Internalization of a peptide bound PPCy is demonstrated using live cell microscopy.
Fachbereich Chemie and Center of Applied Photonics, Universität Konstanz, 78457 Konstanz, Germany.
Georg Michael
GM
Fischer
Christian
C
Jüngst
Magnus
M
Isomäki-Krondahl
Dominik
D
Gauss
Heiko Michael
HM
Möller
Ewald
E
Daltrozzo
Andreas
A
Zumbusch
D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D013237:Stereoisomerism
D005456:Fluorescent Dyes; D011758:Pyrroles