[Small bowel adenocarcinoma].
Small bowel adenocarcinoma is a rare tumor. These tumors are more often sporadic but there is some predisposing disease (Crohn disease, genetic syndrome and rarely celiac disease). Diagnosis is usually performed at an advanced stage because of non-specific nature of clinical manifestations. New methods of radiological and endoscopic exploration of small intestine should allow earlier diagnosis. Surgical resection remains the only potentially curative treatment for non-metastasic tumors. The main prognosis factor is lymph nodes involvement. The role of adjuvant chemotherapy is unclear. For metastatic tumors, 5-fluorouracil and platinum salt combination appears to be the most effective chemotherapy despite of the absence of randomized studies. A national prospective cohort study is currently evaluating the results of chemotherapy (recommended protocol: FOLFOX) as adjuvant and palliative treatment of small bowel adenocarcinoma.
Zaanan
A
A
Service d'oncologie médicale, hôpital Saint-Antoine, Paris, France. aziz.zaanan@gmail.com
Afchain
P
P
Carrere
N
N
Aparicio
T
T
D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D020022:Genetic Predisposition to Disease; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D011379:Prognosis; D012307:Risk Factors