A three-year-analysis of fixed drug eruptions in hospital settings in France.
Fixed drug eruption (FDE) is one of the most typical cutaneous drug adverse reactions. This localized drug-induced reaction is characterized by its relapse at the same sites. Few large series of FDE are reported. The aim of this study was to retrospectively collect and analyse well informed cases observed in a hospital setting. This study involved 17 academic clinical centers. A French nation-wide retrospective multicentric study was carried out on a 3-year-period from 2005 to 2007 by collecting data in seventeen departments of dermatology in France. Diagnosis of FDE was based essentially on clinical findings, at times confirmed by pathological data and patch-testing. Records were reviewed for demographics, causative drugs, localization, severity, and patch-tests, when available. Fifty nine cases were analysed. Patients were 59-years-old on average, with a female predilection. The most common drug was paracetamol, followed by the non-steroidal anti inflammatory drugs. The time between drug intake and skin symptoms was, on average, two days. Beside these classical characteristics, some original findings were found including, a frequent non pigmentation course and a sex-dependent pattern of distribution. Women often had lesions on the hands and feet, and men on the genitalia. Given the fact that skin pigmentation is an inconstant feature of FDE, its French name (erythème pigmenté fixe) should be reconsidered. The sex-dependent distribution could help our understanding of the pathophysiology of fixed drug eruption.
Department of Dermatology, Bichat Hospital, APHP, 46 rue Henri-Huchard, 75877 Paris, France.
Nesrine
N
Brahimi
Emilie
E
Routier
Nadia
N
Raison-Peyron
Anne-Fleur
AF
Tronquoy
Caroline
C
Pouget-Jasson
Stéphanie
S
Amarger
Laurent
L
Machet
Emmanuelle
E
Amsler
Antoine
A
Claeys
Bruno
B
Sassolas
Dominique
D
Leroy
Anne
A
Grange
Alain
A
Dupuy
Nadège
N
Cordel
Jean-Marie
JM
Bonnetblanc
Brigitte
B
Milpied
Marie-Sylvie
MS
Doutre
Marie-Thérèse
MT
Guinnepain
Annick
A
Barbaud
Olivier
O
Chosidow
Jean-Claude
JC
Roujeau
Bénédicte
B
Lebrun-Vignes
Vincent
V
Descamps
D000082:Acetaminophen / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000009:adverse effects; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002648:Child; D003875:Drug Eruptions / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012189:Retrospective Studies
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen