Links between granuloma annulare, necrobiosis lipoidica diabeticorum and childhood diabetes: a matter of time?
Diabetes mellitus is associated with a range of dermatologic presentations, including granuloma annulare and necrobiosis lipoidica diabeticorum. Granuloma annulare occurs earlier than necrobiosis lipoidica diabeticorum and the association with diabetes mellitus is much weaker. We describe two children with diabetes who both developed granuloma annulare and later, necrobiosis lipoidica diabeticorum. We postulate that the early onset and transient nature of granuloma annulare, compared with the later onset and persistence of necrobiosis lipoidica diabeticorum, might account for the different apparent rates of association with diabetes mellitus.
Davison
James E
JE
Department of Paediatrics, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, UK.
Davies
Alison
A
Moss
Celia
C
Kirk
Jeremy M W
JM
Taibjee
Saleem M
SM
Agwu
J Chizo
JC
D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D005260:Female; D016460:Granuloma Annulare / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D009335:Necrobiosis Lipoidica / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D007004:Hypoglycemic Agents; D008687:Metformin