Aging and cancer: are sirtuins the link?
Classically, aging has been defined as a general degeneration process that leads to the loss of corporal function. The loss of function caused by degeneration limits the maximum lifespan of all organisms and is linked to disease and cancer. Nevertheless, the molecular mechanisms behind aging and their connection to cancer are not well understood. NAD-dependent protein deacetylase enzymes, sirtuins, are emerging as a novel molecular link between aging and cancer due to their specific role in cell cycle regulation, antistress response and cell survival. This article reviews the contribution of sirtuins and environmental factors to ontogenic development, senescence and cancer.
Rodriguez
Ramon M
RM
Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.
Fraga
Mario F
MF
D000107:Acetylation; D017677:Age Distribution; D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence / Q000502:physiology; D004198:Disease Susceptibility; D004777:Environment; D042822:Genomic Instability; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008322:Mammals / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000209:etiology* / Q000503:physiopathology; D011499:Protein Processing, Post-Translational; D037761:Sirtuins / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology
D037761:Sirtuins