Adiponectin sparks an interest in calcium.
Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism via activation of AMP-activated protein kinase. Recent work in Nature (Iwabu et al., 2010) demonstrates that adiponectin induces a marked Ca(2+) influx in skeletal muscle via AdipoR1 to control mitochondrial biogenesis, reduce oxidative stress, and enhance endurance capacity.
Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia.
Darren C
DC
Henstridge
Mark A
MA
Febbraio