New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity.
Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.
The School of Chemistry, University of East Anglia, Norwich, UK NR4 7TJ.
Amany E
AE
Ragab
Sabine
S
Grüschow
Emma J
EJ
Rackham
Rebecca J M
RJ
Goss
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry* / Q000378:metabolism; D007536:Isomerism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D011741:Pyrimidine Nucleosides / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism; D013379:Substrate Specificity
D000900:Anti-Bacterial Agents; D010455:Peptides; D011741:Pyrimidine Nucleosides