Pediatric HIV infection and bone health: an emerging challenge.
The available data indicate that HIV-infected children and adolescents have reduced bone mass compared to healthy peers. The increased survival due to the control of HIV infection by potent antiretroviral treatment, exposes patients to the achievement of a reduced peak bone mass and to an increased fracture risk during adult life. Reduced bone mass in HIV-infected children is the result of altered bone metabolism, showing significantly increased bone resorption rate. Both infection per se and the use of certain antiretroviral compounds seem to contribute to the altered metabolism. Preventative measures to improve bone health are thus necessary in all young patients that exhibit low bone mass measurements and altered bone metabolism.
Mora
Stefano
S
Laboratory of Pediatric Endocrinology and BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milan, Italy. mora.stefano@hsr.it
Zamproni
Ilaria
I
Zuccotti
Gianvincenzo
G
Vigano
Alessandra
A
D015502:Absorptiometry, Photon; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D002648:Child; D015658:HIV Infections / Q000503:physiopathology*; D006801:Humans; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography