A human immunodeficiency virus-positive infant with probable congenital histoplasmosis in a nonendemic area.
A 5-week-old infant presented with a fever, and was diagnosed with congenital human immunodeficiency virus and histoplasmosis. Both infections were likely transmitted vertically. The child was effectively treated with antifungal medications and highly active antiretroviral therapy. This represents the first case of delayed presentation of vertically transmitted histoplasmosis, and the first case in a nonendemic area.
Department of Pediatrics, Hasbro Children's Hospital, Brown University, Providence, RI, USA. balverson@lifespan.org
Brian
B
Alverson
Nicole
N
Alexander
Mark P
MP
LeGolvan
Whitney
W
Dunlap
Carly
C
Levy
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006166:Guatemala / Q000208:ethnology; D015658:HIV Infections / Q000150:complications / Q000151:congenital / Q000175:diagnosis* / Q000635:transmission; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000821:virology; D018445:Infectious Disease Transmission, Vertical; D017964:Itraconazole / Q000627:therapeutic use; D009035:Mothers
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B