Increased expression of Aquaporin-4 and its correlation with contrast enhancement and perilesional edema in brain tumors.
BACKGROUND
Aquaporins and astrocytes are important in maintaining water hemostasis in brain. Upregulation of AQP-4 has been described in conditions associated with brain edema.


OBJECTIVE
To study the expression of aquaporin-4 in brain tumors and its correlation with contrast enhancement and perilesional edema.


METHODS
30 cases of brain tumors, both benign and malignant were included in the study to look for expression of AQP-4.


RESULTS
AQP-4 expression was increased in brain tumors compared to normal brain but distribution and intensity of expression depend upon the type of tumor. A trend toward increased AQP-4 expression in enhancing lesions with perilesional edema was noticed.


CONCLUSIONS
AQP-4 expression was seen in tumor tissue and perilesional reactive astrocytes in primary brain tumors, however only perilesional astrocytes showed positivity in secondary brain tumors. AQP-4 could be playing a role in alteration of blood-brain barrier leading to contrast enhancement and perilesional edema. Increased knowledge of Aquaporins may open new targeted therapy for brain edema.
Dua
Rakesh K
RK
Department of Neurosurgery, NIMHANS, Bangalore, India. dua_rakesh@hotmail.com
Devi
B Indira
BI
Yasha
T C
TC
D051401:Aquaporin 4 / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000378:metabolism; D001929:Brain Edema / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D015854:Up-Regulation
D051401:Aquaporin 4; D003287:Contrast Media