Synthesis, characterization and antimicrobial evaluation of some new 1,3-thiazole-2,4-diamine derivatives.
Various N,N'-diaryl-1,3-thiazole-2,4-diamines (3a-w) were synthesized by a three steps process. The structures of the synthesized compounds were confirmed by spectral data and elemental analyses. All the synthesized compounds were tested against two bacterial strains and two fungal strains. Bacterial strains included Gram positive Staphylococcus aureus and Gram negativeve Escherichia coli and fungal strains included Monascus purpurea and Penicillium citrinum. Most of the compounds showed moderate to good antibacterial as well as antifungal activity.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India. nadeems_03@yahoo.co.in
Nadeem
N
Siddiqui
Shaquiquzzaman
Mujeeb
M
ur Rahman
M Faiz
MF
Arshad
Waquar
W
Ahsan
M Shamsher
MS
Alam
Sharique
S
Ahmed
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002855:Chromatography, Thin Layer; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003959:Diamines; D013844:Thiazoles