Preservation of ovarian function by ovarian transposition prior to concurrent chemotherapy and pelvic radiation for cervical cancer. A case report and review of the literature.
BACKGROUND
For over 45 years, ovarian transposition has been proposed for patients with cervical cancer to preserve ovarian function prior to pelvic radiation. We report a case of preservation of ovarian function and regular normal menstrual cycles after pelvic cisplatin-based chemoradiation and perform a literature review.


METHODS
A 29-year-old female with cervical cancer underwent laparoscopic ovarian transposition prior to cisplatin-based chemoradiation. At 3-year follow-up after completion of her chemoradiation treatment indicated that she was still free of any disease. She is experiencing normal menstrual cycles at regular monthly intervals.


CONCLUSIONS
The present case shows that it is possible to retain ovarian function and menstrual cycles by ovarian transposition prior to pelvic chemoradiation. This provides an option for cervical cancer patients who desire preservation of ovarian function.
Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands. c.bloemers@nki.nl
M C W M
MC
Bloemers
L
L
Portelance
C
C
Legler
M C
MC
Renaud
S L
SL
Tan
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005298:Fertility / Q000502:physiology; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D010053:Ovary / Q000637:transplantation*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D002945:Cisplatin