Early urine output predicts graft survival after kidney transplantation.
BACKGROUND
In kidney transplantations, the identification of early postoperative parameters with high predictive power for the development of late allograft dysfunction has important implications for clinical practice. This study sought to determine these parameters in a single-center cohort.


METHODS
We studied 82 deceased donor renal transplantation. We assessed the following measures: dialysis-dependent delayed graft function (ddDGF), extended DGF, serum creatinine level at day 7, creatinine reduction ratio at day 7, urine output at day 1 and at day 7 posttransplantation (UO7).


RESULTS
Only UO7 showed a significant result upon multivariate analysis (P < .0001). It was less influenced by dialysis with respect to measures based upon serum creatinine. By Receiver Operating characteristic (ROC) analysis, it showed an elevated area under the curve (0.811), with a cut-off value of 500 mL/24 h, showing high sensitivity (98.5%).


CONCLUSIONS
UO7 may be of clinical utility to assess the risk for subsequent renal dysfunction.
Department of General Surgery and Organ Transplantation, La Sapienza Università di Roma, Umberto I Policlinico di Roma, Rome, Italy. lai.quirino@libero.it
Q
Q
Lai
R
R
Pretagostini
L
L
Poli
G B
GB
Levi Sandri
F
F
Melandro
M
M
Grieco
G
G
Spoletini
M
M
Rossi
P B
PB
Berloco
D000328:Adult; D000368:Aged; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000453:epidemiology / Q000503:physiopathology; D004231:Diuresis / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012372:ROC Curve; D012086:Reoperation / Q000706:statistics & numerical data; D014019:Tissue Donors
D003404:Creatinine