Relation of new and old formulas for estimating creatinine clearance among stroke survivors.
OBJECTIVE
To assess whether the newly proposed formula for estimating glomerular filtration function (GFR) - the Chronic Kidney Disease Epidemiology (CKD-EPI) equation - would be materially distinct from the established Modification of Diet in Renal Disease (MDRD) equation in diagnosing chronic kidney disease (CKD) among US stroke survivors.


METHODS
Data from the National Health and Nutrition Examination Survey from 1999-2004, a nationally representative sample of adults from the United States, were used to assess the correlation between the MDRD and CKD-EPI equations among persons aged > or = 55 years who had experienced a prior stroke. CKD was defined as GFR <60 ml/min/1.73 m(2).


RESULTS
Among 6,382 adults, 5,321 (83%) had full and complete data. With MDRD, 20.4% of the sample had CKD vs. 19.4% using the CKD-EPI. There was 97.7% agreement between MDRD and CKD-EPI using the 60 ml/min/ 1.73 m(2) cutoff point. The correlation between both equations was extremely high (r = 0.954).


CONCLUSIONS
The newly developed CKD-EPI equation is very highly correlated to the more established MDRD formula and does not materially change CKD diagnosis made by the latter among persons with a history of stroke.
Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA. ovibes@mednet.ucla.edu
Bruce
B
Ovbiagele
D003404:Creatinine / Q000378:metabolism*; D005919:Glomerular Filtration Rate; D006305:Health Status Indicators; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000209:etiology; D007677:Kidney Function Tests; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009749:Nutrition Surveys; D012307:Risk Factors; D013223:Statistics as Topic; D020521:Stroke / Q000150:complications / Q000473:pathology*; D017741:Survivors; D014481:United States
D003404:Creatinine