Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.
Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR. XMRV-specific sequences were detected in 2%-3% of samples from 168 immunocompetent carriers and approximately 10% of samples from 161 immunocompromised patients.
Institute for Medical Microbiology and Virology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. nfischer@uke.de
Nicole
N
Fischer
Claudia
C
Schulz
Kristin
K
Stieler
Oliver
O
Hohn
Christoph
C
Lange
Christian
C
Drosten
Martin
M
Aepfelbacher
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D015750:Genes, gag; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012137:Respiratory System / Q000821:virology*; D012141:Respiratory Tract Infections / Q000150:complications; D012192:Retroviridae Infections / Q000150:complications / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D017423:Sequence Analysis, RNA; D013183:Sputum / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology* / Q000635:transmission / Q000821:virology
D012367:RNA, Viral