Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness.
A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.
Department of Pediatric Medicine, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, India. drsriramk@yahoo.com
Sriram
S
Krishnamurthy
Anju
A
Seth
Archana
A
Puri
Rama
R
Anand
Satinder
S
Aneja
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy* / Q000473:pathology; D010048:Ovarian Cysts / Q000188:drug therapy* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013577:Syndrome; D013963:Thyroid Hormones / Q000627:therapeutic use*; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D013963:Thyroid Hormones; D013974:Thyroxine