Smad anchor for receptor activation (SARA) in TGF-beta signaling.
Smad anchor for receptor activation (SARA) is known as Smad cofactor that interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor. SARA plays an essential role in TGF-beta-induced Smad2 activation and it may modulate TGF-beta signaling through regulating the balance between Smad2 and Smad3. SARA also functions as an anchor for catalytic subunit of protein phosphatase 1 (PP1c) and maybe involved in the dephosphorylation of TGF-beta type I receptor (TbetaR-I) mediated by Smad7. The expression of SARA changes as the development of epithelial to mesenchymal transition (EMT) and fibrosis and it plays a critical role in the maintenance of epithelial cell phenotype. Modulation of SARA may provide a new therapeutic approach to TGF-beta-mediated EMT and fibrosis.
Tang
Wen-bin
WB
Department of Nephrology, Kidney institute, Central South University, the Second Xiangya Hospital, Changsha, China.
Ling
Guang-hui
GH
Sun
Lin
L
Liu
Fu-You
FY
D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology; D012697:Serine Endopeptidases / Q000378:metabolism*; D015398:Signal Transduction; D051899:Smad2 Protein / Q000378:metabolism; D051900:Smad3 Protein / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D051899:Smad2 Protein; D051900:Smad3 Protein; D016212:Transforming Growth Factor beta; C116420:ZFYVE16 protein, human; D012697:Serine Endopeptidases