Determinants of homocysteine levels in Ivorian rural population.
In the present study, homocysteine (Hcy) and vitamin B status were determined in healthy subjects living in two opposite regions of the Ivory Coast. Fifty-six subjects from a coastal region (Bodou) having a fish-based diet and 56 subjects from a mountainous area (Glanle) having a vegetarian diet were tested to sample Hcy, folate, vitamin B12, creatinine, and lipid levels, as well as inflammation and nutritional parameters. An increased prevalence of Hcy > or = 15 micromol/L was observed, reaching 60 % of all subjects. The Bodou group exhibited significantly higher Hcy levels than the Glanle group [20.1 (9.7 - 41.4) vs. 13.6 (5.5 - 48.7) micromol/L, p<0.0001], despite higher vitamin B12 levels [593 (163 - 1860) vs. 234 (83 - 585) pg/mL, p<0.0001]. Although folate levels were lower in subjects from Bodou compared to Glanle [3.2 (2.0 - 7.3) vs. 6.0 (1.9 - 18.2) ng/mL, p<0.0001], there was no significant relationship with Hcy levels in any groups. Interestingly, there were significantly higher creatinine levels in subjects from Bodou compared to Glanle and a significant positive relationship with Hcy levels was evident in each group. In conclusion, Hcy levels in an Ivorian population having a fish-based diet appeared significantly higher compared to subjects having a vegetarian diet. However, folate and vitamin B12 status did not emerge as the major determinants of this difference; a stronger relationship was observed with creatinine levels.
Tiahou
Georges
G
Laboratoire de Biochimie Médicale, Université Bouake, Bouake, Cote d'Ivoire.
Dupuy
Anne-Marie
AM
Jaussent
Isabelle
I
Sees
Daniel
D
Cristol
Jean-Paul
JP
Badiou
Stephanie
S
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D007560:Cote d'Ivoire; D003404:Creatinine / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D012709:Serum Albumin / Q000378:metabolism; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood*; D055815:Young Adult
D012709:Serum Albumin; D014280:Triglycerides; D006710:Homocysteine; D002097:C-Reactive Protein; D005492:Folic Acid; D002784:Cholesterol; D003404:Creatinine; D014805:Vitamin B 12