The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid-filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow-up experiment, we hypothesized that the protein-bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.
Mason
Stephen B
SB
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Lai
Xianyin
X
Bacallao
Robert L
RL
Blazer-Yost
Bonnie L
BL
Gattone
Vincent H
VH
Wang
Kevin C
KC
Witzmann
Frank A
FA