Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta4.
Neurotrophic corneal defects are difficult to heal and all too often lead to scarring and vision loss. Medical management is often of limited success. We describe the results of nine patients (ages 37-84) with chronic nonhealing neurotrophic corneal epithelial defects who were treated with thymosin beta 4 (Tbeta4) sterile eye drops for 28 or 49 days with a follow-up period of 30 days. Those with geographic defects (six patients) showed dramatic healing without clinically significant neovascularization. Stromal thinning was observed in one patient. Three patients with punctate epithelial defects did not have a demonstrable change in their clinical findings. Reduced ocular irritation was reported by all patients soon after treatment initiation. Results from these compassionate use cases indicate that Tbeta4 may provide a novel, topical approach to wound healing in chronic nonhealing neurotrophic corneal ulcers.
Department of Ophthalmology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA. stevenpdunn@ameritech.net
Steven P
SP
Dunn
David G
DG
Heidemann
Christopher Y C
CY
Chow
David
D
Crockford
Nabila
N
Turjman
Janet
J
Angel
Christian B
CB
Allan
Gabriel
G
Sosne
D000287:Administration, Topical; D000818:Animals; D057176:Compassionate Use Trials; D003315:Cornea / Q000503:physiopathology*; D003320:Corneal Ulcer / Q000188:drug therapy; D005123:Eye; D005128:Eye Diseases / Q000188:drug therapy; D006801:Humans; D051379:Mice; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000627:therapeutic use; D013947:Thymosin / Q000008:administration & dosage* / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects; D000099201:Thymosin beta(4)
D009883:Ophthalmic Solutions; D013947:Thymosin; D000099201:Thymosin beta(4)