Langerhans cell histiocytosis with digestive tract involvement.
Gastrointestinal tract (GIT) involvement in Langerhans cell histiocytosis (LCH) is not commonly described. We present two children presenting with GIT involvement with LCH, one successfully treated on standard protocol and other being treated on a protocol for relapsed disease. A review of literature showed almost 95% children were less than 2 years of age and 62% were females. Vomiting, abdominal pain, constipation, intractable diarrhea, malabsorption, bloody stools, protein-losing enteropathy, and even intestinal perforation are some of the reported symptoms. More than 50% patients died within 18 months from diagnosis.
Pediatric Haematology and Oncology and Bone Marrow Transplantation Unit, Department of Pediatrics, Center for Child Health, Sir Ganga Ram Hospital, Delhi, India. satya 1026@hotmail.com
Satya P
SP
Yadav
Gaurav
G
Kharya
Neelam
N
Mohan
Anupam
A
Sehgal
Sunil
S
Bhat
Sandeep
S
Jain
Gauri
G
Kapoor
Anupam
A
Sachdeva
D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D016896:Treatment Outcome