Evaluation of optic nerve head configurations of superior segmental optic hypoplasia by spectral-domain optical coherence tomography.
OBJECTIVE
To characterise the optic nerve head (ONH) configurations of superior segmental optic hypoplasia (SSOH) using a spectral-domain optical coherence tomography (SD-OCT).


METHODS
Horizontal cross-sectional images of the ONH were obtained by a SD-OCT in 20 eyes of 14 patients with clinically typical SSOH and 20 age- and refraction-matched normal eyes.


RESULTS
Extension of retinal pigment epithelium (RPE) over the disc margin was observed in 20 eyes (100%) with SSOH and eight (40%) control eyes (p<0.001). The maximum length of the overhanging RPE measured at the nasal disc margin was significantly longer in eyes with SSOH than in controls (295.9+/-112.6 vs 24.3+/-33.9 microm; p<0.0001). In eyes with SSOH, the retinal nerve fibre layer (RNFL) was significantly thinner in the temporal-superior to nasal sectors (p<0.01).


CONCLUSIONS
The extension of RPE over the nasal disc margin was more common and longer in eyes with SSOH than in normal eyes, suggesting that the SD-OCT findings might facilitate the diagnosis of SSOH. Substantial thinning of the RNFL was present in wider areas than previously expected in SSOH.
Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Keiko
K
Hayashi
Atsuo
A
Tomidokoro
Shinsuke
S
Konno
Chihiro
C
Mayama
Makoto
M
Aihara
Makoto
M
Araie
D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000002:abnormalities*; D009900:Optic Nerve / Q000002:abnormalities; D055351:Retinal Neurons / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000002:abnormalities; D041623:Tomography, Optical Coherence / Q000379:methods