An Efficient Gatekeeper Algorithm for Detecting GxE.
The risk for many complex diseases is believed to be a result of the interactive effects of genetic and environmental factors. Developing efficient techniques to identify gene-environment interactions (GxE) is important for unraveling the etiologic basis of many modern day diseases including cancer. The problem of false positives and false negatives continues to pose significant roadblocks to detecting GxE and informing targeted public health screening and intervention. A heuristic gatekeeper method is presented to guide the selection of single nucleotide polymorphisms (SNPs) in the design phase of a GxE study.
Biostatistics and Data Management Unit, Center for Health of Vulnerable Populations, University of North Carolina, 237-A McIver Building, Administrative Drive, Greensboro, NC 27402-6170, USA. Email: jimmy.efird@stanfordalumni.org.
Jimmy T
JT
Efird