Shell-cross-linked micelles from PNIPAM-b-(PLL)2 Y-shaped miktoarm star copolymer as drug carriers.
Well-defined AB2 Y-shaped miktoarm star copolymers of PNIPAM-b-(PZLL)2 and PNIPAM-b-(PLL)2 were synthesized through the combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and click chemistry, where PNIPAM, PZLL, and PLL are poly(N-isopropylacrylamide), poly(epsilon-benzyloxy-carbonyl-L-lysine), and poly(L-lysine), respectively. Propargyl amine was employed as ROP initiator for the preparation of alkynyl-terminated PZLL. Diazide-terminated PNIPAM was obtained with an azide-containing ATRP initiator. The subsequent click reaction led to the formation of PNIPAM-b-(PZLL)2. After the removal of the benzyloxycarbonyl group, water-soluble PNIPAM-b-(PLL)2 was obtained. The core-shell micelles of PNIPAM-b-(PLL)2 were formed above lower critical solution temperature of PNIPAM block. At this temperature, the shell cross-linking was performed through the reaction between glutaraldehyde and the primary amine groups of the PLL shell, affording the micelles with the endurance to temperature and pH changes. These shell-cross-linked micelles were used as drug nanocarriers and the release profile was dually controlled by the solution temperature and the cross-linking degree.
Department of Polymer Science and Engineering, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Li-Ying
LY
Li
Wei-Dong
WD
He
Jian
J
Li
Bo-Yu
BY
Zhang
Ting-Ting
TT
Pan
Xiao-Li
XL
Sun
Zong-Lei
ZL
Ding
D000180:Acrylic Resins / Q000737:chemistry; D000588:Amines; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D005976:Glutaral; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D011107:Polylysine / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000627:therapeutic use; D013696:Temperature
D000180:Acrylic Resins; D000588:Amines; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D011107:Polylysine; C052970:poly-N-isopropylacrylamide; D005976:Glutaral