[Risk of anastomotic leakage in postoperative treatment with non-steroidal anti-inflammatory drugs].
Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis.
Klein
Mads
M
Herlev Hospital, Gastroenheden Kirurgisk Sektion, Denmark. madsklein@hotmail.com
Gögenur
Ismail
I
Rosenberg
Jacob
J
D000714:Anastomosis, Surgical / Q000009:adverse effects*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology*; D011720:Pyrazoles / Q000009:adverse effects; D012307:Risk Factors; D013449:Sulfonamides / Q000009:adverse effects; D014945:Wound Healing / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D004008:Diclofenac; D000068579:Celecoxib