Antimicrobial activity of new 4,6-disubstituted pyrimidine, pyrazoline, and pyran derivatives.
A number of new 2,6-didisubstituted pyrimidine, pyrazoline, and pyran derivatives were synthesized starting from their chalcone derivative. The synthesized compounds displayed different degrees of antimicrobial activity against Bscillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes).
Ramiz
Mahmoud M M
MM
Department of Physics and Mathematical Engineering, Menoufia University, Menouf, Egypt.
El-Sayed
Wael A
WA
El-Tantawy
Asmaa I
AI
Abdel-Rahman
Adel A-H
AA
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D047188:Chalcones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests / Q000379:methods; D008956:Models, Chemical; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
D000890:Anti-Infective Agents; D047188:Chalcones; D011714:Pyrans; D011720:Pyrazoles; D011743:Pyrimidines