Vitamin D in kidney disease: pathophysiology and the utility of treatment.
Vitamin D physiology has gained more importance and publicity than any of its counterparts in the water- and fat-soluble vitamin groups combined. This is partly because vitamin D deficiency is still widely prevalent in the developed world and the beneficial effects are thought to extend beyond the regulation of calcium and phosphorus homeostasis alone. Vitamin D deficiency becomes even more important in the various stages of chronic kidney disease (CKD); CKD itself is also on the increase. How vitamin D physiology is altered in CKD and how the various treatment modalities can alter the morbidity and mortality associated with CKD is the topic of discussion for this article.
Division of Nephrology, Saint Louis University, Saint Louis, MO 63110, USA. qazir@SLU.EDU
Rizwan A
RA
Qazi
Kevin J
KJ
Martin
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism; D002908:Chronic Disease; D019587:Dietary Supplements; D050723:Fractures, Bone / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D054559:Hyperphosphatemia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007674:Kidney Diseases / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D010758:Phosphorus / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*
D014807:Vitamin D; D010758:Phosphorus; D002118:Calcium