Contribution of Cyclophilin A to determination of simian immunodeficiency virus tropism: a progress update.
An understanding of cellular factors that affect viral replication contributes to elucidation of the mechanism for the determination of viral tropism. Cyclophilin A (CypA), a peptidyl-prolyl cis-trans isomerase (PPIase), is an essential host factor for the efficient replication of human immunodeficiency virus type 1 (HIV-1) in human cells. However, its role in simian immunodeficiency virus (SIV) replication has not been determined. In the 2008 US-Japan AIDS panel meeting, I have presented the effect of cyclosporine A (CsA), a PPIase inhibitor, on replication of wild-type SIV. Interestingly, CsA treatment enhanced SIV replication in human cells but abrogated SIV replication in macaque cells, implying a species-specific effect of CsA on SIV replication. After this meeting, analysis using CypA knocked-down human cells indicated that CypA was considered inhibitory for SIV replication. These results suggest possible involvement of CypA in the determination of SIV tropism.
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. htake@ims.u-tokyo.ac.jp
Hiroaki
H
Takeuchi
D000818:Animals; D002460:Cell Line; D021984:Cyclophilin A / Q000378:metabolism*; D016572:Cyclosporine / Q000494:pharmacology; D055785:Gene Knockdown Techniques; D016346:Gene Products, vif; D006801:Humans; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D013045:Species Specificity; D056189:Viral Tropism; D014779:Virus Replication
D016346:Gene Products, vif; D016572:Cyclosporine; D021984:Cyclophilin A