Heart rate and systolic blood pressure in patients with persistent atrial fibrillation. A linguistic analysis.
BACKGROUND
During atrial fibrillation (AF), ventricular response is highly irregular and thus the beat-to-beat variation of blood pressure is increased because of variations in filling time and in contractility.


OBJECTIVE
Aim of the present study is to investigate the short-term dynamics of RR and SAP series in patients with AF, during rest and tilt, and after restoration of sinus rhythm.


METHODS
We computed symbolic sequences of the three phases, as they retain important features of the dynamics generated by the underlying control system. Then we applied a method based on rank order statistics of symbolic sequences to investigate the profile of different types of dynamics. The linguistic distance (range 0-1) between sequences represents a measure of similarity to assess whether the different physiological states are reflected on the dynamics of RR and SAP series.


RESULTS
The distance between rest and tilt phases is 0.06 ± 0.02 for RR series, meaning they are very similar, while it is 0.21 ± 0.13 for SAP series, showing a difference in the short-term dynamics. RR mean decreases during tilt (738 ± 164 vs. 692 ± 152 ms, p <0.05, rest vs. tilt), while mean SAP is not significantly different (101 ± 20 vs. 104 ± 14 mmHg, rest vs. tilt). Comparing AF and sinus rhythm, both RR and SAP series result different in terms of the computed distance.


CONCLUSIONS
SAP short-term dynamics seem to significantly change when comparing rest and tilt phases, while RR series remain unchanged. Moreover, RR mean but not SAP series significantly decreases during tilt.
Corino
V D A
VD
Department of Bioengineering, Politecnico di Milano, Via Golgi 39, 20131 Milano, Italy. valentina.corino@polimi.it
Belletti
S
S
Terranova
P
P
Lombardi
F
F
Mainardi
L T
LT
D001281:Atrial Fibrillation / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008037:Linguistics; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D012016:Reference Values; D018709:Statistics, Nonparametric