Study of lipid profile, lipid peroxidation and vitamin E in pregnancy induced hypertension.
Pregnancy-induced hypertension (PIH) is a common medical complication of pregnancy with a high incidence. The study comprised of 30 normal and 30 PIH cases in their third trimester of pregnancy and the following estimations were done: Serum Malondialdehyde level (MDA), Vitamin E, triglycerides (TG), total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-C. The PIH cases had significant rise in both systolic and diastolic blood pressure (BP) (P=<0.0001). There was a significant rise in the fasting triglycerides, total cholesterol and LDL-C levels in PIH (P=<0.0001). MDA was twice in the cases and Vitamin E was half the levels that of controls (P=<0.0001). The level of rise of serum lipids did not significantly correlate with the rise or fall in MDA. In PIH cases there was a negative correlation of diastolic BP with MDA (P<0.05). Early detection of these parameters is going to aid in better management of PIH cases.
Department of Biochemistry, Pondicherry Institute of Medical Sciences, Kalapet, Pondicherry - 605 014. suchandasahu@rediffmail.com
Suchanda
S
Sahu
Rebecca
R
Abraham
R
R
Vedavalli
Mary
M
Daniel
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D015227:Lipid Peroxidation / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D014810:Vitamin E; D008315:Malondialdehyde