MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.
A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
Kolodziej
Stephen A
SA
Department of Medicinal Chemistry, Pfizer Research & Development, St. Louis, MO 63198, USA.
Hockerman
Susan L
SL
DeCrescenzo
Gary A
GA
McDonald
Joseph J
JJ
Mischke
Debbie A
DA
Munie
Grace E
GE
Fletcher
Theresa R
TR
Stehle
Nathan
N
Swearingen
Craig
C
Becker
Daniel P
DP
D000284:Administration, Oral; D000577:Amides; D000818:Animals; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D061965:Matrix Metalloproteinase Inhibitors; D051381:Rats; D054852:Small Molecule Libraries; D012995:Solubility; D013379:Substrate Specificity; D013450:Sulfones
D000577:Amides; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D054852:Small Molecule Libraries; D013450:Sulfones