The use of transgenic mouse models in the study of male infertility.
Over the past few decades with the rapid advances in embryo and embryonic stem cell manipulation techniques, transgenic mouse models have emerged as a powerful tool for the study of gene function and complex diseases including male infertility. In this review we give a brief history of the development of tools for the production of transgenic mouse models. This spans the advances from early pronuclear injection to the use of targeted embryonic stem cells to produce gene targeted, conditional, and inducible knockout mouse models. Lastly we provide a few examples to illustrate the utility of mouse models in the study of male infertility.
Transgenic and Gene Targeting Mouse Core, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.
Susan
S
Tamowski
Kenneth I
KI
Aston
Douglas T
DT
Carrell
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D018390:Gene Targeting; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic