Malignant transformation of a benign oncocytoma of the submandibular gland: a case report.
Oncocytic carcinoma arising in the submandibular gland is an extremely rare tumor and only 11 cases have been reported previously. We report on a 51-year-old man with a previously benign oncocytoma in the submandibular gland that transformed from a benign morphology to malignant cellular atypia and mitosis. To our knowledge, the current report is the first published case of a malignant transformation from benign oncocytoma to oncocytic carcinoma of the submandibular gland. The proliferative activity of the tumor cells was evaluated immunohistochemically using antibodies against Ki-67.
Lee
Tsung-Hsun
TH
Department of Otolaryngology, Chi-Mei Medical Center, Yung Kung City 710, Tainan County, Taiwan.
Lin
Yung-Song
YS
Lee
Wen-Ying
WY
Wu
Tai-Ching
TC
Chang
Shih-Lun
SL
D018249:Adenoma, Oxyphilic / Q000473:pathology* / Q000503:physiopathology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D013365:Submandibular Gland Neoplasms / Q000473:pathology* / Q000503:physiopathology