Evaluation of optic nerve head configurations of superior segmental optic hypoplasia by spectral-domain optical coherence tomography.
OBJECTIVE
To characterise the optic nerve head (ONH) configurations of superior segmental optic hypoplasia (SSOH) using a spectral-domain optical coherence tomography (SD-OCT).


METHODS
Horizontal cross-sectional images of the ONH were obtained by a SD-OCT in 20 eyes of 14 patients with clinically typical SSOH and 20 age- and refraction-matched normal eyes.


RESULTS
Extension of retinal pigment epithelium (RPE) over the disc margin was observed in 20 eyes (100%) with SSOH and eight (40%) control eyes (p<0.001). The maximum length of the overhanging RPE measured at the nasal disc margin was significantly longer in eyes with SSOH than in controls (295.9+/-112.6 vs 24.3+/-33.9 microm; p<0.0001). In eyes with SSOH, the retinal nerve fibre layer (RNFL) was significantly thinner in the temporal-superior to nasal sectors (p<0.01).


CONCLUSIONS
The extension of RPE over the nasal disc margin was more common and longer in eyes with SSOH than in normal eyes, suggesting that the SD-OCT findings might facilitate the diagnosis of SSOH. Substantial thinning of the RNFL was present in wider areas than previously expected in SSOH.
Hayashi
Keiko
K
Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Tomidokoro
Atsuo
A
Konno
Shinsuke
S
Mayama
Chihiro
C
Aihara
Makoto
M
Araie
Makoto
M
D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000002:abnormalities*; D009900:Optic Nerve / Q000002:abnormalities; D055351:Retinal Neurons / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000002:abnormalities; D041623:Tomography, Optical Coherence / Q000379:methods