Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients.
OBJECTIVE
The aim of this study was to evaluate the association and interaction of genotypic polymorphisms in the cyclooxygenase 2 (Cox-2) gene with smoking habits with lung cancer patients in Taiwan. Six polymorphic variants of Cox-2 were analysed in association with their effect on lung cancer susceptibility, and their joint effects with smoking habits on lung cancer risk is discussed.


METHODS
Three hundred and fifty-eight patients with lung cancer and 716 healthy controls from the China Medical Hospital in central Taiwan were genotyped.


RESULTS
The Cox-2 intron 6 (rs2066826) genotypes were distributed differently between the lung cancer and control groups. The A allele of Cox-2 intrin 6 was found more frequently in the cancer patient group than in the controls. Furthermore, the interactions of smoking with genetic factors were significant for the Cox-2 intron 6 genotypes. Patients who smoked and had the Cox-2 intron 6 AG or AA genotype had an increased risk of 2.21 (95% confidence interval=1.53-3.27) for developing lung cancer.


CONCLUSIONS
These results provide evidence that the A allele of Cox-2 intron 6 may be associated with the development of lung cancer and may be a useful marker for early detection and treatment of lung cancer.
Department of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taiwan.
Chin-Jung
CJ
Liu
Te-Chun
TC
Hsia
Rou-Fen
RF
Wang
Chia-Wen
CW
Tsai
Chia-Chen
CC
Chu
Liang-Wen
LW
Hang
Chung-Hsing
CH
Wang
Hong-Zin
HZ
Lee
Ru-Yin
RY
Tsai
Da-Tian
DT
Bau
D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D013624:Taiwan / Q000453:epidemiology
D014408:Biomarkers, Tumor; D051546:Cyclooxygenase 2