Roux-en-Y bypass gastroplasty: markers of oxidative stress 6 months after surgery.
BACKGROUND
This study examined the effect of weight loss on energy intake, vitamin C, E, beta-carotene (diet/blood), reduced glutathione (GSH), C-reactive protein (CRP), thiobarbituric acid reactive substances (TBARS), catalase, and myeloperoxidase, in patients with Roux-en-Y bypass gastroplasty.


METHODS
Prospective clinical study with control (C) and bariatric (B) groups (n = 20 each). Age was 38.8 +/- 11.1 (C) and 37.8 +/- 11.2 years (B), and body mass indices (BMI) were 22.4 +/- 2.4 and 48.1 +/- 8.7 kg/m(2), respectively. Group C was assessed on a single occasion and B at three time points (basal period and 3 and 6 months after gastroplasty).


RESULTS
BMI was decreased at three (38.3 +/- 1.7, P = 0.018) and 6 months after surgery (34.9 +/- 1.7, P < 0.001). Mean weight loss was 20.53 +/- 1.1 after three and 27.96 +/- 1.3 kg after 6 months. Serum vitamin C and beta-carotene (P < 0.01 and P < 0.001, respectively) were increased at 6 months compared to basal. Basal serum vitamin C (P = 0.001) and beta-carotene (P < 0.001) were lower compared to controls. Serum vitamin E corrected for cholesterol and triglycerides was higher in group B at three (P = 0.01) and 6 months (P = 0.001) and lower at basal (P < 0.001) compared to controls. GSH was higher in controls (P < 0.001) compared to basal. Catalase (P = 0.01) and TBARS (P < 0.001) were higher in group B at 6 months. TBARS were higher (P < 0.001) at basal compared to controls. Myeloperoxidase and CRP decreased in group B after three (P = 0.028, P = 0.010) and 6 months (P < 0.001, P = 0.001), respectively.


CONCLUSIONS
Roux-en-Y bypass gastroplasty led to decreased proinflammatory parameters together with increased nutritional antioxidants, catalase, and TBARS, and decreased GSH 6 months after surgery.
Post-Graduate Program in Nutrition, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Fernanda
F
Boesing
Emilia Addison Machado
EA
Moreira
Danilo
D
Wilhelm-Filho
Silvana Virgínia Gagliotti
SV
Vigil
Eduardo Bennedetti
EB
Parizottto
Déborah Bunn
DB
Inácio
Guilherme Vannucchi
GV
Portari
Erasmo Benício Santos Moraes
EB
Trindade
Alceu Afonso
AA
Jordão-Júnior
Tânia Silvia
TS
Fröde
D000328:Adult; D000975:Antioxidants / Q000032:analysis; D001205:Ascorbic Acid / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002374:Catalase / Q000097:blood; D004032:Diet; D002149:Energy Intake; D005260:Female; D015390:Gastric Bypass; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014810:Vitamin E / Q000097:blood; D015431:Weight Loss; D019207:beta Carotene / Q000097:blood
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D019207:beta Carotene; D014810:Vitamin E; D002097:C-Reactive Protein; D002374:Catalase; D009195:Peroxidase; D005978:Glutathione; D001205:Ascorbic Acid