Protein microarrays for cancer diagnostics and therapy.
In this postgenomic age, cancer will be understood in intricate detail beyond the genomic level. New technologies are emerging that allow global proteomic level characterization, profiling and understanding. One of the most exciting emerging technologies of cancer proteomics is protein microarray. In this review, the different types of protein microarrays are discussed, including the methods, challenges and techniques of each type. Subsequently, the application of these specific methods to cancer diagnosis, prognosis and therapy will be overviewed, providing a general review of current methods, and proposing how protein arrays will help shape the future of oncoproteomics.
Lin
Jimmy Cheng-Ho
JC
Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA. jimmy.lin@jhmi.edu
D014408:Biomarkers, Tumor; D006801:Humans; D013058:Mass Spectrometry; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D011379:Prognosis; D040081:Protein Array Analysis / Q000379:methods*; D040901:Proteomics
D014408:Biomarkers, Tumor