Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis.
Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii. Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.
Gan
Chew-Yan
CY
Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Etoh
Tadahiro
T
Hayashi
Masahiko
M
Komiyama
Kanki
K
Kam
Toh-Seok
TS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007624:KB Cells; D008296:Malaysia; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031451:Strychnos / Q000737:chemistry*; D014750:Vincristine / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D014750:Vincristine