Microwave-assisted copper(II)-catalyzed one-pot four-component synthesis of multifunctionalized dihydropyridines.
A fast and highly efficient copper-catalyzed multicomponent synthesis of 1,4-dihydropyridines under microwave irradiation is described. The protocol utilizes mild reaction conditions with low catalytic loading, leading to high yields. This methodology provides us with biologically active 1,4-dihydropyridine library for medicinal chemistry applications.
Pasunooti
Kalyan Kumar
KK
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical, Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Nixon Jensen
Chantel
C
Chai
Hua
H
Leow
Min Li
ML
Zhang
Da-Wei
DW
Liu
Xue-Wei
XW
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D004095:Dihydropyridines; D054852:Small Molecule Libraries; D003300:Copper