Initial experience involving treatment and retreatment with carmustine wafers in combination with oral temozolomide: long-term survival in a child with relapsed glioblastoma multiforme.
BACKGROUND
Glioblastomas occur infrequently in children, and the prognosis is better than for glioblastomas seen in adults. Aggressive treatment is justified in pediatric patients.


METHODS
We present the case of a 6-year-old child with malignant posterior temporal glioma treated with surgery, radiotherapy, local chemotherapy with carmustine wafers, and oral therapy with temozolomide, both at initial diagnosis and at relapse 18 months later. After 6 years, the patient seems healthy with no focal neurologic signs, and imaging studies show no evidence of disease.


CONCLUSIONS
Multimodal therapy was found to have a very positive outcome for a child with malignant glioma.
Department of Neurosurgery, Virgen del Rocío University Hospitals, Sevilla, Spain. jaca5@arrakis.es
Javier
J
Márquez-Rivas
Gema
G
Ramirez
Angela
A
Ollero-Ortiz
Jorge
J
Giménez-Pando
Juan
J
Emmerich
Eduardo
E
Quiroga-Cantero
Eloy
E
Rivas
Emilio
E
Gómez-González
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002330:Carmustine / Q000008:administration & dosage; D002648:Child; D003131:Combined Modality Therapy; D003399:Craniotomy; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D019233:Retreatment; D000077204:Temozolomide; D016896:Treatment Outcome
D003606:Dacarbazine; D002330:Carmustine; D000077204:Temozolomide