Hematology. Are macrophages the bad guys in Hodgkin lymphoma?
Prognostic models for patients with Hodgkin lymphoma are imperfect and do not allow a precise individualized therapy. A recent gene-expression profiling study, translated into a routine immunohistological test, identified genes of tumor-associated macrophages as being responsible for treatment outcome in patients with Hodgkin lymphoma. If this finding is confirmed by other investigators, it could be a major step towards personalized therapy for patients with Hodgkin lymphoma.
Diehl
Volker
V
Department of Internal Medicine, Hematology-Oncology, University of Cologne, Joseph-Stelzmanstrasse 9, Cologne, Germany. v.diehl@uni-koeln.de
D019411:Clinical Laboratory Techniques; D020869:Gene Expression Profiling; D006403:Hematologic Tests; D006689:Hodgkin Disease / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D008264:Macrophages / Q000473:pathology; D046228:Microarray Analysis; D011379:Prognosis; D013267:Stilbenes; D016896:Treatment Outcome
D013267:Stilbenes; C006711:benzoylamido-4'-aminostilbene-2,2'-disulfonate