The inhibitory effect of ginseng pectin on L-929 cell migration.
We tested the effects of ginseng pectin prepared by enzymatic hydrolysis of ginseng polysaccharides on cell migration. Ginseng pectin impaired the migration of L-929 cells and reduced their migration speed by up to 50% of control in the presence or absence of serum, suggesting it worked on both serum-dependent and serum-independent migration pathways. Ginseng pectin impaired cell migration via decreased cell spreading. These findings represent a significant contribution towards understanding the bioactivities of ginseng polysaccharides and applying them to health food and medicine.
Fan
Yuying
Y
Northeast Normal University, Changchun, Jilin Province, China.
Cheng
Hairong
H
Liu
Dan
D
Zhang
Xu
X
Wang
Bo
B
Sun
Lin
L
Tai
Guihua
G
Zhou
Yifa
Y
D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D006868:Hydrolysis; D005894:Panax / Q000737:chemistry*; D010368:Pectins / Q000138:chemical synthesis / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry
D011134:Polysaccharides; D010368:Pectins