Radiation-induced olfactory neuroblastoma: a new etiology is possible.
OBJECTIVE
Radiation-induced olfactory neuroblastoma (ONB) is an uncommon neoplasm that is generally associated with a poor prognosis. We describe a new case of olfactory neuroblastoma in a patient previously treated for astrocytoma with holocranial radiotherapy 9 years ago.


METHODS
We reviewed the medical records of four patients with radiation-induced olfactory neuroblastoma between 2001 and 2009.


RESULTS
This work supports the idea that ONB can be induced by radiation.


CONCLUSIONS
As radiotherapy is a standard treatment in other tumors, clinicians must be aware of the possibility of a second tumor induced by radiation.
Oral and Maxillofacial Surgery Service, Gregorio Maranon Hospital, Complutense University, Madrid, Spain. veronipg@gmail.com
Veronica
V
Perez Garcia
Maria de los Angeles
Mde L
Martinez Izquierdo
D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009296:Nasal Cavity; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery; D009669:Nose Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery; D011867:Radioisotope Teletherapy / Q000009:adverse effects*; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant
D003037:Cobalt Radioisotopes