[Effect of Lycium barbarum polysaccharides on neurogenesis and learning & memory in manganese poisoning mice].
OBJECTIVE
To study the effect of Lycium barbarum polysaccharides (LBP) on neurogenesis and learning & memory of manganese poisoning mice.


METHODS
Healthy adult Kunming mice were divided into 5 groups, the control group (A), the manganese poisoning (by manganese chloride peritoneal injection) group (B), the manganese poisoning and treated with gastric perfusion of high, medium, low dosage LBP groups (C, D and E). The spatial learning & memory capacity of mouse was determined by Morris water maze training test. The neurogenetic cells were labelled with bromodeoxyuridine (BrdU) and detected by immunohistochemistry.


RESULTS
The average escape latency was significantly higher and the times of passing through platform lower in group B than those in group A (P<0.05). BrdU positive cells in groups C, D and E were significantly more than those in group B (P<0.05).


CONCLUSIONS
LBP could enhance the learning & memory capability of the manganese poisoning mice by promoting neurogenesis in hippocampus.
Wen
Jing
J
Department of Human Anatomy, Guangxi Medical University, Nanning 530021.
Yang
Bo-ning
BN
Ren
Dan
D
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D020149:Manganese Poisoning; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D055495:Neurogenesis / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; C500223:lycium barbarum polysaccharide