Use of lamotrigine in a patient with a clozapine-related seizure.
Seizures can be a serious adverse effect of clozapine, often a last-resort antipsychotic with unique efficacy for some patients. Several anticonvulsants have been reported to be useful in preventing further clozapine-induced seizures and permitting continued treatment with this medication. The authors describe the first reported successful use of lamotrigine for this purpose.
Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA.
Andrew
A
Muzyk
Gary
G
Gala
David A
DA
Kahn
D000927:Anticonvulsants / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D000077213:Lamotrigine; D016651:Lithium Carbonate / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy*; D014227:Triazines / Q000627:therapeutic use*; D055815:Young Adult
D000927:Anticonvulsants; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D014227:Triazines; D016651:Lithium Carbonate; D003024:Clozapine; D000077213:Lamotrigine