[Cancer vaccine].
Cancer vaccine is an intervention for therapeutic or prophylactic option by activating antitumor immune responses in vivo. Vaccine to human papillomavirus is clinically available, which prevents women from developing cervical cancer. Therapeutic cancer vaccines have been studied in randomized clinical trials. Melanoma vaccine using a gpl00 -peptide has been analyzed in recurrent disease patients. Patients treated with peptide vaccine with high-dose IL-2 lived longer than those with IL-2 alone. Another clinical trial covered hormone-resistant prostate cancer patients who were treated with dendritic cell (DC) vaccine of prostate-acid protein plus GM-CSF. DC-vaccinated patients significantly lived longer than those with placebo, though no difference of disease progression was seen between the two groups. Worldwide phase III study of MAGE-A3 vaccine for non-small cell lung cancer has been initiated. Its analysis on clinical benefits will be expected. Vaccine therapy for cancer would be another option for clinical practice in near
Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine.
Shinichi
S
Kageyama
D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000145:classification / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control* / Q000628:therapy; D016032:Randomized Controlled Trials as Topic
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines