The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.
BACKGROUND
A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.


METHODS
Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.


RESULTS
Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).


CONCLUSIONS
These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy.
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong. scwtang@hku.hk
Sydney C W
SC
Tang
Violet T M
VT
Leung
Loretta Y Y
LY
Chan
Sunny S H
SS
Wong
Daniel W S
DW
Chu
Joseph C K
JC
Leung
Yiu Wing
YW
Ho
Kar Neng
KN
Lai
Lijun
L
Ma
Steven C
SC
Elbein
Donald W
DW
Bowden
Pamela J
PJ
Hicks
Mary E
ME
Comeau
Carl D
CD
Langefeld
Barry I
BI
Freedman
D000103:Acetyl-CoA Carboxylase / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000208:ethnology* / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000208:ethnology* / Q000209:etiology / Q000235:genetics*; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014481:United States
C520105:ACACB protein, human; D000103:Acetyl-CoA Carboxylase