Chemistry and biology of orexin signaling.
The orexins are neurohormones that, in concert with their cognate receptors, regulate a number of important physiological processes, including feeding, sleep, reward seeking and energy homeostasis. The orexin receptors have recently emerged as important drug targets. This review provides an overview of recent development in deciphering the biology of orexin signaling as well as efforts to manipulate orexin signaling pharmacologically.
Kodadek
Thomas
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Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. Kodadek@scripps.edu
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D000818:Animals; D016739:Behavior, Addictive / Q000378:metabolism / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000209:etiology; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009479:Neuropeptides / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D009765:Obesity / Q000209:etiology; D000068797:Orexins; D015398:Signal Transduction / Q000502:physiology; D012890:Sleep / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins