Fasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study - suggestion for the threshold for impaired fasting glucose among Japanese.
To determine the optimal fasting plasma glucose (FPG) cut-off value which effectively identifies high risk subjects for type 2 diabetes in Japanese, we conducted a population-based prospective study on diabetes as part of the Japan Public Health Center-based Prospective Study and estimated the 5-year incidence of diabetes. The subjects of the analysis of this study were 2,207 Japanese aged 51-70 at baseline from whom a fasting blood sample was collected in both the baseline and the 5-year follow-up surveys and who completed the questionnaires at both times. Diabetes was defined as an FPG value > or = 126 mg/dL (7.0 mmol/L) and/or self-reported diabetes. A total of 125 subjects developed diabetes during the 5 years after the baseline survey, and the incidence rate for a baseline FPG value of 95-99, 100-104, 105-109, 110-114, 115- 119, and 120-125 mg/dL was 6.1, 11.5, 30.3, 52.6, 86.4, and 115.2 per 1,000 person-years, respectively. The results of receiver operating characteristic curve analysis suggested that an FPG value of 102 mg/dL (5.67 mmol/L) was optimal for predicting diabetes during the next 5-years. The cut-off value was similar in both genders and in the 51- to 60-year-old group and 61- to 70-year-old group. Use of hemoglobin A(1c) level > or = 6.1% for an additional diagnostic criterion resulted in a small increment in incidence, but the cut-off value for predicting diabetes was almost the same (101 mg/dL). The results of this study suggested that the cut-off FPG value should be lowered in terms of prediction of type 2 diabetes among Japanese populations.
Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. mnoda@hosp.ncgm.go.jp
Mitsuhiko
M
Noda
Masayuki
M
Kato
Yoshihiko
Y
Takahashi
Yumi
Y
Matsushita
Tetsuya
T
Mizoue
Manami
M
Inoue
Shoichiro
S
Tsugane
Takashi
T
Kadowaki
D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D005215:Fasting / Q000097:blood* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005951:Glucose Tolerance Test / Q000592:standards; D006287:Health Planning Guidelines; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values
D001786:Blood Glucose