Phenyl-substituted dihydropyrazines with DNA strand-breakage activity.
Monophenyl-substituted dihydropyrazines (Ph-DHP-1 to 4) of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP-1), which have the inductive effects of apoptosis and mutagenesis, were synthesized and their biological effect was investigated in terms of DNA strand-breakage. Differences between the phenyl- and methyl-substituted dihydropyrazines were examined.
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University.
Shigeru
S
Ito
Shinji
S
Takechi
Kazuhide
K
Nakahara
Nobuhiro
N
Kashige
Tadatoshi
T
Yamaguchi
D004247:DNA / Q000378:metabolism*; D053960:DNA Breaks / Q000187:drug effects*; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology*
D011719:Pyrazines; D004247:DNA