Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim culture.
BACKGROUND
Candida glabrata endophthalmitis following keratoplasty is rare and almost always associated with positive donor rim culture.


METHODS
A 63-year-old patient, diagnosed Fuch's endothelial dystrophy in both eyes underwent a penetrating keratoplasty in his right eye. He had multiple underlying medical problems, which included diabetes mellitus, hypertension, hypoadrenalism on oral dexamethasone and fatty liver secondary to hypertrigliseridemia. He developed multiple suture abscesses, corneal haziness, retrocorneal white plaques and a level of hypopyon two weeks after an uneventful penetrating keratoplasty in his right eye. Cultures of the donor button and the transport media culture were negative. Candida glabrata was isolated successfully from the aqueous and vitreous taps. He was treated with a combination of topical, intracameral, intravitreal and intravenous Amphotericin B. His final visual acuity remained poor due to the haziness of the corneal button.


CONCLUSIONS
Candida glabrata endophthalmitis following penetrating keratoplasty can occur in negative donor rim and transport media cultures. The growth of the organism is facilitated by the patient's immunocompromised status. Awareness by the ophthalmologists and appropriate choice of antibiotics are mandatory in this challenging condition.
Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Mohd Nor
MN
Muzaliha
Hussein
H
Adil
Mohtar
M
Ibrahim
Ismail
I
Shatriah
D000038:Abscess / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D041221:Candida glabrata / Q000302:isolation & purification*; D002177:Candidiasis / Q000209:etiology*; D004334:Drug Administration Schedule; D009877:Endophthalmitis / Q000382:microbiology* / Q000473:pathology; D005128:Eye Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery*; D006801:Humans; D056965:Injections, Intraocular; D007275:Injections, Intravenous; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013537:Sutures / Q000009:adverse effects; D019737:Transplants / Q000382:microbiology*; D014463:Ultrasonography; D014822:Vitreous Body / Q000000981:diagnostic imaging
D000935:Antifungal Agents; D000666:Amphotericin B