Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach.
Patients with autoimmune inner ear disease develop rapidly progressive sensorineural hearing loss over a period of several weeks or months, often accompanied by vestibular loss. This disease can occur as a distinct clinical entity or in association with an underlying autoimmune disorder. Treatment comprises immunosuppression by corticosteroids, cytostatic drugs or tumor necrosis factor-α antagonists. We report histopathological and immunohistochemical findings of the inner ear of a patient with a granulomatous inner ear disease suffering from Crohn's disease that was nonresponsive to treatment and who underwent surgery for bilateral cochlear implants.
Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. m.dettmer@gmx.net
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M
Dettmer
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Hegemann
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Hegemann
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D019929:Cochlear Implantation; D003054:Cochlear Implants; D003424:Crohn Disease / Q000276:immunology / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007759:Labyrinth Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology