Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration.
Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-alpha-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-alpha-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.
Assmann
Ulrike
U
Deutsches Institut für Kautschuktechnologie e.V., Eupener Strasse 33, 30519 Hannover, Germany.
Szentivanyi
Andreas
A
Stark
Yvonne
Y
Scheper
Thomas
T
Berski
Silke
S
Dräger
Gerald
G
Schuster
Robert H
RH
D049109:Cell Proliferation; D002478:Cells, Cultured; D048091:Guided Tissue Regeneration; D019158:N-Acetylneuraminic Acid; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves; D012583:Schwann Cells / Q000502:physiology; D012794:Sialic Acids; D054457:Tissue Scaffolds
D012794:Sialic Acids; C021319:polysialic acid; D019158:N-Acetylneuraminic Acid