Innate immunity.
Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.
Ooi
Eng H
EH
Department of Otolaryngology Head and Neck Surgery, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Room 413, Toronto, ON M5G 1X5, Canada.
Psaltis
Alkis J
AJ
Witterick
Ian J
IJ
Wormald
Peter-John
PJ
D018441:Biofilms; D003550:Cystic Fibrosis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D016207:Cytokines / Q000276:immunology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D009079:Mucociliary Clearance / Q000502:physiology*; D009093:Mucus; D017354:Point Mutation / Q000235:genetics; D012220:Rhinitis / Q000150:complications / Q000276:immunology / Q000473:pathology; D012852:Sinusitis / Q000150:complications / Q000276:immunology / Q000473:pathology; D051193:Toll-Like Receptors
C505032:CFTR protein, human; D016207:Cytokines; D051193:Toll-Like Receptors; D019005:Cystic Fibrosis Transmembrane Conductance Regulator