Intravascular lymphomatosis and intracerebral haemorrhage.
Intravascular lymphomatosis (IVL) is a rare, malignant B- or T-cell lymphoma with remarkable affinity for the endothelial cells of small vessels, particularly within the skin and central nervous system. It is a disease that mimics several neurological disorders, particularly those of cerebrovascular ischemic origin. The prognosis is generally poor, with a rapidly fatal outcome. As a result the diagnosis is often made at post-mortem. We report a rare case of a 73-year-old patient with IVL complicated by intracerebral haemorrhage. In literature two cases of systemic IVL complicated by intracerebral haemorrhage have been reported, but they presented initially with a disseminated intravascular coagulation (DIC). This is the first case of brain IVL complicated by intracerebral haemorrhage not associated to DIC. Increasing awareness of this disease as a differential diagnosis to a common clinical presentation may lead to more opportunities to evaluate new diagnostic and treatment approaches.
Passarin
Maria Grazia
MG
Division of Neurology, Department of Medicine, Bussolengo Hospital, Via Ospedale 2, Bussolengo, Verona, Italy. mariagraziapassarin@hotmail.it
Wen
Patrick Y
PY
Vattemi
Emanuela
E
Buffone
Ebba
E
Ghimenton
Claudio
C
Bontempini
Lamberto
L
Ottaviani
Sarah
S
Musso
Anna Maria
AM
Pedersini
Rebecca
R
D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography