Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review.
Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).
Charafeddine
Khalil M
KM
Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon.
Mahfouz
Rami A
RA
Zaatari
Ghazi S
GS
Ibrahim
Georges Y
GY
Muwakkit
Samar A
SA
Najm
Nada D
ND
Farra
Chantal G
CG
D000328:Adult; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D055728:Primary Myelofibrosis / Q000235:genetics*; D013920:Thrombocythemia, Essential / Q000235:genetics*