[A comparative study on the risks of esophagus-cancer patients among factors as blood relatives, paternal line, matriarchal and different sex].
OBJECTIVE
In order to provide new clues on the cause of esophagus-cancer through seeking for information among the relatives of esophagus-cancer-patients at high-risk, contrast analysis was carried out to compare the ORs between esophagus-cancer cases and the relatives of the patients.


METHODS
Case-control study was adopted on 720 cases and 720 controls who were kin relatives of the patients.


RESULTS
(1) Risk of the relatives to the esophagus-cancer-patient group (1.34% - 2.24%) was obviously higher than the control group (0.78% - 1.21%) (P < 0.01). In 1(st) grade relatives, the risk of parent's to the esophagus-cancer patients (6.11%) was obviously higher than the control group (2.97%) (P < 0.01). (2) According to the cascade analysis to the cases of both paternal and matriarchal, lines, results showed that the risks of both the paternal line (0.87% - 1.01%) and the matriarchal line (0.50% - 0.79%) in the group of esophagus-cancer cases were all obviously higher than the lines in the control groups (0.53% - 0.65%) and (0.38% - 0.47%). Data also showed that the risk among the male relatives of paternal line (eg: grandfathers', father's, uncles' etc.) in the group of cases was 2.68% while the matriarchal (eg: grandmother's, mother's, aunts' etc.) was 1.91%. Both figures were obviously higher than that in the control group (1.50% and 0.92%, P < 0.01).


CONCLUSIONS
The risk factor of esophagus cancer of the next generation seemed higher if the father and his brothers or mother and her sisters having had esophagus-cancers.
Wang
Yuan
Y
Provincial Research Institute of Tumor, Shanxi, Taiyuan 030013, China. 865925755@qq.com
Han
Xiao-you
XY
Ding
Ti
T
Xu
Yi
Y
Wang
Quan-hong
QH
D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors