The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis.
Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.
Burda
P
P
Department of Pathophysiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Laslo
P
P
Stopka
T
T
D000818:Animals; D050980:GATA Transcription Factors / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D000099232:Proto-Oncogene Protein Spi-1
D050980:GATA Transcription Factors; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1