Corneal biomechanical properties and intraocular pressure in high myopic anisometropia.
OBJECTIVE
To investigate corneal biomechanical properties and intraocular pressure (IOP) in patients with high myopic anisometropia.


METHODS
Patients with high myopic anisometropia (n = 23) and emmetropic subjects (n = 55) were enrolled. Corneal hysteresis (CH), Goldmann-correlated intraocular pressure (IOPg), corneal resistance factor, and corneal-compensated IOP (IOPcc) were measured with Ocular Response Analyzer. Central corneal thickness was measured by optical coherence tomography. Zeiss IOL-Master determined the values of corneal refractive power and ocular axial length.


RESULTS
Significant differences were presented in CH, IOPg, and IOPcc among the high myopic, contralateral, and normal eyes (analysis of variance, P<0.05). CH in high myopic eye was lower than that in the other two groups (post hoc, P<0.05), whereas IOPg and IOPcc in both eyes of anisometropic myopia were higher compared with the normal subjects (post hoc, P<0.01). CH was associated with central corneal thickness and axial length in high myopic eyes. All measured biometric parameters showed significant correlations between two eyes in high myopic anisometropia.


CONCLUSIONS
High myopic eyes showed decreased CH, but not corneal resistance factor, which indicates that some aspects of corneal biomechanical properties may be altered in high myopic eye of anisometropia. It is also suggested that anisometropic eyes with different refractive errors do not share the same biomechanical properties, which may impact IOP measurement.
Xu
Suzhong
S
School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China.
Xu
Aiqin
A
Tao
Aizhu
A
Wang
Jianhua
J
Fan
Fan
F
Lu
Fan
F
D000293:Adolescent; D000328:Adult; D015858:Anisometropia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D001696:Biomechanical Phenomena; D003315:Cornea / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence; D055815:Young Adult