[The association between Apolipoprotein E genotype and lipid profiles in healthy woman workers].
OBJECTIVE
Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade.


METHODS
The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR.


RESULTS
The relative frequencies of alleles E2, E3 and E4 for the study population (n=305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol.


CONCLUSIONS
This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.
Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD., Korea.
Kieun
K
Moon
Sook Hee
SH
Sung
Youn Koun
YK
Chang
Il Keun
IK
Park
Yun Mi
YM
Paek
Soo Geun
SG
Kim
Tae In
TI
Choi
Young Woo
YW
Jin
D000328:Adult; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011322:Primary Prevention
D001057:Apolipoproteins E; D008076:Cholesterol, HDL