[Estimate of the cardiovascular disease burden attributable to modifiable risk factors in Argentina].
OBJECTIVE
Estimate the burden of disease, the proportion attributable to the principal modifiable cardiovascular risk factors, and the direct medical cost of hospitalization associated with coronary heart disease and stroke in Argentina.


METHODS
An analitical model was prepared using Argentina's 2005 mortality data and the prevalence of the principal cardiovascular risk factors (hypertension, hypercholesterolemia, overweight, obesity, hyperglycemia, current and past smoking, sedentary lifestyle, and inadequate intake of fruits and vegetables). The burden of disease-years of potential life lost (YPLL) and years of healthy life lost (YHLL)- and hospitalization costs for the cardiovascular diseases analyzed were estimated.


RESULTS
In 2005 over 600 000 YHL were lost in Argentina and the number of YPLL due to heart disease and stroke was calculated at 400 000; 71.1% of the YHLL, 73.9% of the YPLL, and 76.0% of the associated costs were attributable to modifiable risk factors. Hypertension was the risk factor with the greatest impact in both men and in women, responsible for 37.3% of the total cost, 37.5% of the YPLL, and 36.6% of the YHLL.


CONCLUSIONS
Most of the burden of disease from cardiovascular disease in Argentina is associated with modifiable, and therefore preventable, risk factors and could be reduced through population-based and clinical interventions that employ a risk approach; such interventions have already proven to be cost effective, accessible, and feasible in countries like Argentina.
Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina. arubinstein@iecs.org.ar
Adolfo
A
Rubinstein
Lisandro
L
Colantonio
Ariel
A
Bardach
Joaquín
J
Caporale
Sebastián
S
García Martí
Karin
K
Kopitowski
Andrea
A
Alcaraz
Luz
L
Gibbons
Federico
F
Augustovski
Andrés
A
Pichón-Rivière
D000328:Adult; D001118:Argentina / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000191:economics / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D003198:Computer Simulation; D017281:Cost of Illness; D004032:Diet / Q000009:adverse effects; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006943:Hyperglycemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008962:Models, Theoretical; D050177:Overweight / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology