Efficacy of standardised manual therapy and home exercise programme for chronic rotator cuff disease: randomised placebo controlled trial.
OBJECTIVE
To investigate the efficacy of a programme of manual therapy and exercise treatment compared with placebo treatment delivered by physiotherapists for people with chronic rotator cuff disease.


METHODS
Randomised, participant and single assessor blinded, placebo controlled trial.


METHODS
Metropolitan region of Melbourne, Victoria, Australia.


METHODS
120 participants with chronic (>3 months) rotator cuff disease recruited through medical practitioners and from the community.


METHODS
The active treatment comprised a manual therapy and home exercise programme; the placebo treatment comprised inactive ultrasound therapy and application of an inert gel. Participants in both groups received 10 sessions of individual standardised treatment over 10 weeks. For the following 12 weeks, the active group continued the home exercise programme and the placebo group received no treatment.


METHODS
The primary outcomes were pain and function measured by the shoulder pain and disability index, average pain on movement measured on an 11 point numerical rating scale, and participants' perceived global rating of overall change.


RESULTS
112 (93%) participants completed the 22 week trial. At 11 weeks no difference was found between groups for change in shoulder pain and disability index (3.6, 95% confidence interval -2.1 to 9.4) or change in pain (0.7, -0.1 to 1.5); both groups showed significant improvements. More participants in the active group reported a successful outcome (defined as "much better"), although the difference was not statistically significant: 42% (24/57) of active participants and 30% (18/61) of placebo participants (relative risk 1.43, 0.87 to 2.34). The active group showed a significantly greater improvement in shoulder pain and disability index than did the placebo group at 22 weeks (between group difference 7.1, 0.3 to 13.9), although no significant difference existed between groups for change in pain (0.9, -0.03 to 1.7) or for the percentage of participants reporting a successful treatment outcome (relative risk 1.39, 0.94 to 2.03). Several secondary outcomes favoured the active group, including shoulder pain and disability index function score, muscle strength, interference with activity, and quality of life.


CONCLUSIONS
A standardised programme of manual therapy and home exercise did not confer additional immediate benefits for pain and function compared with a realistic placebo treatment that controlled for therapists' contact in middle aged to older adults with chronic rotator cuff disease. However, greater improvements were apparent at follow-up, particularly in shoulder function and strength, suggesting that benefits with active treatment take longer to manifest.


BACKGROUND
Clinical trials NCT00415441.
Bennell
Kim
K
Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, University of Melbourne, Parkville 3010, Victoria, Australia. k.bennell@unimelb.edu.au
Wee
Elin
E
Coburn
Sally
S
Green
Sally
S
Harris
Anthony
A
Staples
Margaret
M
Forbes
Andrew
A
Buchbinder
Rachelle
R
D000368:Aged; D002908:Chronic Disease; D006233:Persons with Disabilities; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000628:therapy*; D026201:Musculoskeletal Manipulations / Q000009:adverse effects / Q000379:methods*; D010349:Patient Compliance; D017006:Rotator Cuff; D020069:Shoulder Pain / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome