[Characteristics of microflora of laryngeal mucosa in healthy subjects and patients with cicatrical stenosis of the larynx].
The authors present data on the occurrence, density, and species composition of microorganisms isolated from pharyngeal mucosa of 40 healthy subjects and 55 patients with cicatrical stenosis of the larynx. The total density of microbial populations in control subjects was estimated at 2,672+/-614 CFU/ml compared with 17,510+/-1,983 CFU/ml in patients with cicatrical stenosis of the larynx unrelated to malignant neoplastic growth and 19,375+/-2,103 CFU/ml in patients who had experienced surgical intervention for the treatment of malignancy. A total of 312 microbial strains were isolated and identified. Coccal bacteria were the predominant group (streptococci-74 strains, neisseria-72, staphylococci-62, micrococci-12). Collectively, they comprised 70.5% of all isolated strains representing autochthonous microflora. Corynebacteria, moraxellas, and enterobacteria (transitory forms) were rare. The occurrence of neisseria, staphylococci and fungi (genus Candida) in patients with cicatrical stenosis of the larynx was significantly higher than in the healthy subjects. Moreover, the patients developed dysbacteriosis with the predominance of N. flavescens, S. aureus, S. epidermidis, S. alpha-haemoliticus, and Candida sp. It is concluded that elucidation of the microbial landscape in patients with cicatrical stenosis of the larynx is of importance for planning prevention and management of pyoseptic complications in the course of surgical treatment.
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Kovalyk
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Govda
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000254:growth & development / Q000302:isolation & purification*; D002921:Cicatrix / Q000150:complications*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000382:microbiology*; D007829:Laryngostenosis / Q000209:etiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged