CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.
Summary Among 288 HIV-1-infected, breastfeeding women who received zidovudine prophylaxis and were followed with their infants in Nairobi, we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, 59356T/C, 59402G/A), RANTES (-403G/A) and SDF-1 (3'801G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine concentrations.
Katz
D A
DA
Department of Epidemiology, University of Washington, Seattle, WA 98104, USA. dkatz7@u.washington.edu
John-Stewart
G C
GC
Richardson
B A
BA
Majiwa
M
M
Mabuka
J M
JM
Lohman-Payne
B
B
Farquhar
C
C
D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001826:Body Fluids / Q000821:virology; D002584:Cervix Uteri / Q000821:virology; D018946:Chemokine CCL5 / Q000032:analysis / Q000235:genetics*; D054377:Chemokine CXCL12 / Q000032:analysis / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D015658:HIV Infections / Q000151:congenital / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics* / Q000635:transmission*; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D007630:Kenya / Q000453:epidemiology; D008895:Milk, Human / Q000737:chemistry / Q000821:virology; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*; D019562:Viral Load; D014766:Viremia / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; C483024:CCL5 protein, human; C515255:CXCL12 protein, human; D018946:Chemokine CCL5; D054377:Chemokine CXCL12; D019713:Receptors, CCR5; D015215:Zidovudine