Recent advances in the field of Salmonella Typhi vaccines.
Typhoid fever, caused by the bacterium Salmonella enterica serovar Typhi, remains a significant cause of human death and disease throughout large areas of the world. Although there are currently three vaccines available against S. Typhi they have a number of significant drawbacks which drive the development of much-needed new and improved versions. Here recent advances towards such vaccines, from basic research to human trials, are discussed.
Paterson
Gavin K
GK
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. gkp27@cam.ac.uk
Maskell
Duncan J
DJ
D006801:Humans; D022562:Salmonella Vaccines / Q000276:immunology*; D012485:Salmonella typhi / Q000276:immunology* / Q000472:pathogenicity*; D014435:Typhoid Fever / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D022223:Vaccines, Subunit / Q000276:immunology
D022562:Salmonella Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D022223:Vaccines, Subunit