Microalbuminuria versus brain natriuretic peptide in cardiac hypertrophy of hypertensive rats.
The objective of this study was to assess a possible link between microalbuminuria (MA), a major risk factor of the cardiorenal syndrome and the brain natriuretic peptide (BNP), a marker of cardiac hypertrophy. Two kidney-one clip (2K-1C) renovascular hypertension was induced in 24 male Wistar rats (weighing 220-250 g). Rats were randomized into four groups for 8 weeks: Sham, not treated; Bos, treated with bosentan; Cap, treated with captopril; Bos/Cap, treated with both drugs. Blood pressure, plasma BNP and transforming growth factor beta1 (TGF-β1) concentrations, microalbuminuria and creatininemia as well as cardiac mass, BNP, alpha- and beta-myosin heavy chain (MHC) gene expression and kidney histology were determined. Following stenosis, Sham rats developed hypertension (p < 0.001), an increase in BNP (p < 0.05) and TGF-β1 (p < 0.005) concentrations, creatinine levels (p < 0.001), and urinary albumin (p < 0.001). Under drug treatment, decreases in blood pressure (p < 0.001), creatinine levels (p < 0.05), plasma TGF-β1 (p < 0.005) and BNP (p < 0.05) concentrations, were concomitant with the absence of MA which was significantly correlated with reductions in cardiac mass (p < 0.05) and hypertrophy markers (BNP and β-MHC gene expression) (p < 0.005) as well as in renal fibrosis. These findings suggest a potential link between microalbuminuria evolution and BNP as well as a possible effect of microalbuminuria-lowering therapy on halting the progression, or even inducing the regression of cardiac hypertrophy.
Laboratoire de Physiologie et Physiopathologie, Faculté de Médecine, Université Saint Joseph, Beyrouth, Liban.
Y
Y
Saliba
E
E
Chouery
A
A
Mégarbané
H
H
Jabbour
N
N
Farès
D000419:Albuminuria / Q000150:complications* / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006332:Cardiomegaly / Q000209:etiology* / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000378:metabolism; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D053773:Transforming Growth Factor beta1 / Q000097:blood
D053773:Transforming Growth Factor beta1; D020097:Natriuretic Peptide, Brain; D003404:Creatinine