[The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma].
OBJECTIVE
To study the relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma (HCC).


METHODS
The expression of FHIT and WWOX were determined by immunohistochemistry in 142 patients with HCC.


RESULTS
Absent or reduced FHIT and WWOX expression was observed in 68.3% and 77.5% of HCCs, respectively. The expression of FHIT was significantly correlated with that of WWOX (P < 0.01), and progressive loss of FHIT and WWOX expression were observed as tumor differentiation decreased and tumor grade increased (P < 0.05). Absent/reduced FHIT and WWOX expression was associated with tumor invasion and metastasis (P < 0.05). In addition, the expression of FHIT and WWOX in HCC with recrudesce were lower than that in those without recrudesce (P < 0.05).


CONCLUSIONS
Absent/reduced FHIT and WWOX expression is associated with poor prognosis.
Department of Pathology, Institution of Oncology, Fujian Medical University, Fuzhou 350004, China.
Jie
J
Lin
Bin
B
Wang
Ai-min
AM
Huang
Xiao-jun
XJ
Wang
D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics*; D011379:Prognosis; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D000074584:WW Domain-Containing Oxidoreductase; D055815:Young Adult; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D010088:Oxidoreductases; D025521:Tumor Suppressor Proteins; D000074584:WW Domain-Containing Oxidoreductase; D000099170:Bis(5'-adenosyl)triphosphatase; C486071:WWOX protein, human