A single center experience of donation after cardiac death liver transplantation in pediatric recipients.
Many centers are now performing DCD adult LT. There has been a reluctance to transplant pediatric recipients with DCD livers due to concern over the medium to long-term outcome. We describe the outcome of 14 children (median age seven yr, 8 months-16 yr) that underwent LT with DCD grafts from July 2001 to December 2007. Donors had a median age of 23 yr (10-64), intensive care stay of five d (2-14) and bilirubin of 9 mmol/L (6-60). Median warm and cold ischemic time was 16 min (11-29) and seven h (5.5-8.4). Livers were transplanted as a whole organ (4), reduced graft (8), formal split (1) or auxiliary transplant (1). Compared to DBD recipients AST was significantly higher on the first three post-operative days and there was no difference in the INR, bilirubin or GGT out to 12 months. There were no biliary or vascular complications and patient and graft survival is 100% at a median follow-up of 41.8 months (1.7-74 months). LT with DCD grafts in pediatric recipients can be performed with low morbidity and excellent short-to-medium term patient and graft outcome.
Institute of Liver Studies and Transplantation, King's College London School of Medicine at King's College Hospital NHS Foundation Trust, London, United Kingdom. adamb@adhb.govt.nz
Adam
A
Bartlett
Roshni
R
Vara
Paolo
P
Muiesan
Paul
P
Mariott
Anil
A
Dhawan
Giorgina
G
Mieli-Vergani
Mohamed
M
Rela
Nigel
N
Heaton
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003643:Death; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D018709:Statistics, Nonparametric; D014184:Transplantation, Homologous; D016896:Treatment Outcome