Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.
In this case series we present a variety of different cardiac toxicities with 5-fluorouracil and its pro-drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, takotsubo cardiomyopathy and QT prolongation with torsade-de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided.
Department of Cardiology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
T
T
Stewart
N
N
Pavlakis
M
M
Ward
D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000139:chemically induced* / Q000175:diagnosis; D000069287:Capecitabine; D054715:Cardiotoxins / Q000008:administration & dosage / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000175:diagnosis; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged
D054715:Cardiotoxins; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil