Are Cox-2 drugs the second line option in indomethacin responsive headaches?
Paroxysmal hemicrania and hemicrania continua are both indomethacin-responsive headaches. Although indomethacin use to be well tolerated, some patients developed gastrointestinal side effects. We report four cases of hemicrania continua and a patient suffering chronic paroxysmal hemicrania completely responsive to celecoxib. In our experience celecoxib is a good option treatment for patients suffering from hemicrania continua or chronic paroxysmal hemicranea that presents indomethacin adverse effects.
Headache Unit, Hospital Universitario Clínico San Carlos, C/ Andrés Torrejón 15, Madrid, Spain. jporta@yahoo.com
Jesús
J
Porta-Etessam
Marialuz
M
Cuadrado
Octavio
O
Rodríguez-Gómez
Sara
S
García-Ptacek
Cristina
C
Valencia
D000328:Adult; D000368:Aged; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006261:Headache / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051302:Paroxysmal Hemicrania / Q000139:chemically induced; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib