T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease.
BACKGROUND
Silicosis is a well-recognized risk factor for tuberculosis (TB).


OBJECTIVE
To compare T-Spot.TB with tuberculin skin test (TST) in predicting the development of TB.


METHODS
Male patients with silicosis without clinical suspicion of active TB, past history of TB, and treatment for latent TB infection (LTBI) were offered both T-Spot.TB and TST in the Pneumoconiosis Clinic of Hong Kong from 2004 to 2008, and followed prospectively until September 30, 2009, for development of TB.


RESULTS
Active TB and culture- or histology-confirmed TB developed in 17 (5.5%) and 14 (4.5%) of 308 recruited subjects at an annual rate of 2,247 and 1,851 per 100,000 person-years, respectively. Active TB occurred in 7.4% (15 of 204) and 1.9% (2 of 104) of T-Spot.TB-positive and -negative subjects, respectively, whereas the corresponding figures for TST (cutoff 10 mm) were 6.4% (13 of 203) and 3.9% (4 of 205), respectively. A positive T-Spot.TB test significantly predicted the subsequent development of active TB (relative risk, 4.50; 95% confidence interval, 1.03-19.68) and culture- or histology-confirmed TB (relative risk, 7.80; 95% confidence interval, 1.02-59.63). Consistent results were obtained after exclusion of subjects treated for LTBI and adjustment for potential confounders. TST did not significantly predict the development of active TB or culture- or histology-confirmed TB, irrespective of the cutoff values with or without exclusion of subjects treated for LTBI. Culture filtrate protein 10 spot count, but not early secretary antigenic target 6 spot count, was significantly associated with subsequent TB development.


CONCLUSIONS
T-Spot.TB performs better than TST in the targeted screening of LTBI among patients with silicosis.
Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China. cc_leung@dh.gov.hk
Chi Chiu
CC
Leung
Wing Cheong
WC
Yam
Wing Wai
WW
Yew
Pak Leung
PL
Ho
Cheuk Ming
CM
Tam
Wing Sze
WS
Law
Ka Fai
KF
Au
Pui Wah
PW
Tsui
D016001:Confidence Intervals; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007371:Interferon-gamma / Q000378:metabolism; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012829:Silicosis / Q000150:complications*; D014374:Tuberculin Test / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000209:etiology
D007371:Interferon-gamma