[Bone and joint diseases in children. Phosphaturic hormone, FGF23, and bone metabolism].
Fibroblast growth factor 23 (FGF23) belongs to FGF19 subfamily, whose members function like endocrine factors, and has a phosphaturic effect, leading to hypophosphatemia associated with rickets or osteomalacia when its concentration in blood is elevated. FGF23 is involved in the pathogenesis in many forms of hypophosphatemia including the autosomal dominant and recessive types, the X-linked type and the tumor-induced type. Alpha klotho, originally discovered as an anti-aging factor, along with the FGF receptor type 1 makes a specific receptor for FGF23.
Department of Pediatrics, Osaka University School of Medicine.
Keiichi
K
Ozono
D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D053098:Familial Hypophosphatemic Rickets / Q000209:etiology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D040181:Genetic Diseases, X-Linked; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology; D007015:Hypophosphatemia, Familial; D010018:Osteomalacia / Q000209:etiology; D010758:Phosphorus / Q000097:blood; D017468:Receptors, Fibroblast Growth Factor
C000717427:FGF23 protein, human; D017468:Receptors, Fibroblast Growth Factor; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23