Recent applications of a synthetic model of cytochrome c oxidase: beyond functional modeling.
This account reports recent developments of a functional model for the active site of cytochrome c oxidase (CcO). This CcO mimic not only performs the selective four-electron reduction of oxygen to water but also catalytically reduces oxygen using the biological one-electron reductant, cytochrome c. This functional model has been used to understand other biological reactions of CcO, for example, the interaction between the gaseous hormone, NO, and CcO. A mechanism for inactivating NO-CcO complexes is found to involve a reaction between oxygen and Cu(B). Moreover, NO is shown to be capable of protecting CcO from toxic inhibitors such as CN(-) and CO. Finally, this functional CcO model has been used to show how H(2)S could induce hibernation by reversibly inhibiting the oxygen binding step involved in respiration.
Collman
James P
JP
Department of Chemistry, Stanford University, Stanford, California 94305, USA. jpc@stanford.edu
Ghosh
Somdatta
S
D040761:Biomimetic Materials / Q000737:chemistry; D020134:Catalytic Domain; D045304:Cytochromes c / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
D007093:Imidazoles; D009942:Organometallic Compounds; D011166:Porphyrins; D045304:Cytochromes c; D003576:Electron Transport Complex IV