Intensive intravesical mitomycin C therapy in non-muscle-invasive bladder cancer: a dose intensity approach.
OBJECTIVE
The aim of this work was to verify the tolerability and the preliminary clinical results of intensive intravesical instillations of a mitomycin C (MMC) regimen.


METHODS
From September 2007 to November 2009, 40 consecutive evaluable patients with pathologically confirmed intermediate-risk non-muscle-invasive bladder cancer (NMIBC) were enrolled after complete transurethral resection of all visible tumors. The mean age of the patients was 64.5 years. 40 mg MMC diluted in 50 ml of saline was instilled in the bladder three times a week for 2 weeks. The median follow-up was 9 months.


RESULTS
All patients fulfilled the scheduled treatment. The local adverse events seen were negligible, while no significant deviation from normal values was observed in blood counts for each patient. Twenty-three of 40 patients (57.5%) showed negative at the cystoscopic control which was performed every 3 months with normal spontaneous and washing cytological exams.


CONCLUSIONS
MMC is a well-known chemotherapeutic agent for the intravesical therapy of NMIBC. With a view to improving its results, we changed the frequency and intensity of the instillations. No significant local or systemic toxicity was reported. Intensive intravesical instillations of MMC might become a tool in the management of NMIBC.
Department of Urology, Catholic University School of Medicine, Rome, Italy. dott.dagostino @ gmail.com
Marco
M
Racioppi
Andrea
A
Volpe
Emanuele
E
Cappa
Daniele
D
D'Agostino
Francesco
F
Pinto
Alessandro
A
D'Addessi
Emilio
E
Sacco
PierFrancesco
P
Bassi
D000283:Administration, Intravesical; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009361:Neoplasm Invasiveness; D013997:Time Factors; D016896:Treatment Outcome; D014521:Urethra / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
D000970:Antineoplastic Agents; D016685:Mitomycin