Ethical issues with informed consent from potential living kidney donors.
Living organ donation and participation in clinical research trials have several features in common from an ethical perspective. The primary similarity is risk justification: the risk of harm to living organ donors and clinical research participants is justified by a resulting benefit to one or more other individuals. Some authors hold that organ donation and clinical trial participation are full-fledged duties. Such an implicit likening of the two leads to several considerations regarding informed consent in each situation. Informed consent raises ethical concerns in every medical context, and some of those concerns, such as competence, understanding, autonomy, and free or voluntary choice, are uniquely relevant to living organ donation and clinical trial participation. Most countries regulate informed consent procedures for living organ donation in great detail, and although informed consent procedures for clinical trial participation are somewhat less detailed, their rules are subject to review by ethics committees. It would be constructive for research participation informed consent procedures and living organ donation informed consent procedures to learn from one another.
Bioethics Unit, Office of the President, Istituto Superiore di Sanità, Rome, Italy. carlo.petrini@iss.it
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D003220:Conflict, Psychological; D004992:Ethics, Medical; D006801:Humans; D007258:Informed Consent / Q000941:ethics*; D007668:Kidney; D019520:Living Donors / Q000941:ethics*; D009392:Nephrectomy / Q000009:adverse effects / Q000941:ethics; D026684:Personal Autonomy; D018570:Risk Assessment; D009927:Tissue and Organ Procurement / Q000941:ethics*