Antibiotics and the burn patient.
Infection is a major problem in burn care and especially when it is due to bacteria with hospital-acquired multi-resistance to antibiotics. Moreover, when these bacteria are Gram-negative organisms, the most effective molecules are 20 years old and there is little hope of any new product available even in the distant future. Therefore, it is obvious that currently available antibiotics should not be misused. With this aim in mind, the following review was conducted by a group of experts from the French Society for Burn Injuries (SFETB). It examined key points addressing the management of antibiotics for burn patients: when to use or not, time of onset, bactericidia, combination, adaptation, de-escalation, treatment duration and regimen based on pharmacokinetic and pharmacodynamic characteristics of these compounds. The authors also considered antibioprophylaxis and some other key points such as: infection diagnosis criteria, bacterial inoculae and local treatment. French guidelines for the use of antibiotics in burn patients have been designed up from this work.
Ravat
François
F
Centre des brûlés, Centre hospitalier St Joseph et St Luc, 20 quai Claude Bernard, 69007 Lyon, France. fravat@ch-stjoseph-stluc-lyon.fr
Le-Floch
Ronan
R
Vinsonneau
Christophe
C
Ainaud
Pierre
P
Bertin-Maghit
Marc
M
Carsin
Hervé
H
Perro
Gérard
G
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D006801:Humans; D017410:Practice Guidelines as Topic; D014946:Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents