Penetrating keratoplasty in active Acanthamoeba keratitis.
OBJECTIVE
To report the results of penetrating keratoplasty (PK) in active Acanthamoeba keratitis (AK).


METHODS
Nine patients with deep stromal infiltrates because of AK were treated with intensive antiamoebic medical therapy followed by PK during the acute infectious phase because of poor clinical response or poor compliance. Antiamoebic therapy was tapered after PK.


RESULTS
Visual acuity ranged from 20/15 to 20/50 after an average of 17 months after PK with no signs of recurrences. Patients had rapid resolution of symptoms.


CONCLUSIONS
PK is a viable option for active AK not responding to maximum medical treatment.
Nguyen
Truc H
TH
Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 13202, USA. tnguyen709@gmail.com
Weisenthal
Robert W
RW
Florakis
George J
GJ
Reidy
James J
JJ
Gaster
Ronald N
RN
Tom
Danita
D
D015823:Acanthamoeba Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003319:Corneal Stroma / Q000469:parasitology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
D000981:Antiprotozoal Agents