Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach.
Patients with autoimmune inner ear disease develop rapidly progressive sensorineural hearing loss over a period of several weeks or months, often accompanied by vestibular loss. This disease can occur as a distinct clinical entity or in association with an underlying autoimmune disorder. Treatment comprises immunosuppression by corticosteroids, cytostatic drugs or tumor necrosis factor-α antagonists. We report histopathological and immunohistochemical findings of the inner ear of a patient with a granulomatous inner ear disease suffering from Crohn's disease that was nonresponsive to treatment and who underwent surgery for bilateral cochlear implants.
Dettmer
M
M
Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. m.dettmer@gmx.net
Hegemann
I
I
Hegemann
S C A
SC
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D019929:Cochlear Implantation; D003054:Cochlear Implants; D003424:Crohn Disease / Q000276:immunology / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007759:Labyrinth Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology