[Meta-analysis on serological effect of the primary vaccination for Japanese encephalitis of the literatures].
OBJECTIVE
To summary and compare the different seroconversion rates after the primary vaccination for the Japanese encephalitis (JE), and to evaluate the serological effect of 3 kinds of JE vaccines.


METHODS
Searching "CHKD", "Wanfang" database and "EMCC" databases, the studies of the immunogenicity after the primary JEV vaccination, all randomized controlled trials or non-randomized controlled trials were included, and statistical analysis were made by RevMan 4.2.10 software.


RESULTS
A total of 12 literatures were included, 7 studies had control groups. The seroconversion rates after the primary vaccination, JEV-L, JEV-I (Vero) and JEV-I (PHK), were 86% (95% CI: 80%-91%), 83% (95% CI: 72% -94%) and 64% (95% CI: 58%-69%) respectively. Comparing the seroconversion rates of the 3 kinds of vaccines after primary immunization, the rate of JEV-I (Vero) was significantly higher than the rate of JEV-I (PHK), other comparisons were no significant difference.


CONCLUSIONS
The serological effects of JEV-L and JEV-I (Vero) after the primary vaccination were higher than that of JEV-I (PHK).
Department of National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zun-dong
ZD
Yin
Hui-ming
HM
Luo
Yi-xing
YX
Li
D000818:Animals; D002460:Cell Line; D004672:Encephalitis, Japanese / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012698:Serologic Tests; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology*
D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated