Severe Plasmodium malariae malaria in a patient with multiple susceptibility genes.
We present a case of severe malaria due to Plasmodium malariae. Genetic testing showed that the patient was homozygous for five important gene polymorphisms previously shown to be associated with increased susceptibility to, and/or severity of, severe sepsis. Our case suggests that P. malariae may cause life-threatening disease, and that disease severity may be linked, at least in part, to multiple susceptibility genes.
Parasitology-Mycology Department, J Minjoz University Hospital, Besançon, France. apbellanger@chu-besancon.fr
Anne-Pauline
AP
Bellanger
Fabrice
F
Bruneel
Olivier
O
Barbot
Jean-Paul
JP
Mira
Laurence
L
Millon
Pascal
P
Houzé
Jean-François
JF
Faucher
Sandrine
S
Houzé
D000328:Adult; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008288:Malaria / Q000235:genetics* / Q000469:parasitology / Q000473:pathology; D008297:Male; D010965:Plasmodium malariae / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018805:Sepsis / Q000235:genetics; D017421:Sequence Analysis; D012720:Severity of Illness Index