Intravascular lymphomatosis and intracerebral haemorrhage.
Intravascular lymphomatosis (IVL) is a rare, malignant B- or T-cell lymphoma with remarkable affinity for the endothelial cells of small vessels, particularly within the skin and central nervous system. It is a disease that mimics several neurological disorders, particularly those of cerebrovascular ischemic origin. The prognosis is generally poor, with a rapidly fatal outcome. As a result the diagnosis is often made at post-mortem. We report a rare case of a 73-year-old patient with IVL complicated by intracerebral haemorrhage. In literature two cases of systemic IVL complicated by intracerebral haemorrhage have been reported, but they presented initially with a disseminated intravascular coagulation (DIC). This is the first case of brain IVL complicated by intracerebral haemorrhage not associated to DIC. Increasing awareness of this disease as a differential diagnosis to a common clinical presentation may lead to more opportunities to evaluate new diagnostic and treatment approaches.
Division of Neurology, Department of Medicine, Bussolengo Hospital, Via Ospedale 2, Bussolengo, Verona, Italy. mariagraziapassarin@hotmail.it
Maria Grazia
MG
Passarin
Patrick Y
PY
Wen
Emanuela
E
Vattemi
Ebba
E
Buffone
Claudio
C
Ghimenton
Lamberto
L
Bontempini
Sarah
S
Ottaviani
Anna Maria
AM
Musso
Rebecca
R
Pedersini
D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D011859:Radiography