[Statistical evaluation of clinical characteristics and therapeutic management of Hodgkin disease in children over a 10 year period].
Hodgkin disease represents the third malign disease like frequency registered to children. Generally, the most cases have been observed to children between 10 and 15 years old.


METHODS
In our study the patients have been investigated on Pediatric Hemato-Oncologic Department from Clinical and Emergencies Hospital for Children "Sf. Maria" Iaşi in a period between 1995 and 2004.


RESULTS
The age of patients was between 2 and 17 years, from this group 31 were boys (54.38%) and 21 girls (45.62%). The medium incidence of disease was 5.7 cases per year. Histological analysis indicates 2 cases with lymphocyte prevalence (3.50%), 18 with nodular sclerosis (31.58%), 32 with mixed cellularity (56.14%) and 5 patients with lymphoid depletion (8.78%). Ann-Arbor classification of disease indicates high frequency of stage II on the beginning (38 cases), with primary localization to neck (52 cases) and mediastinum (29 cases). 35 patients have presented biochemical syndrome (stage b). After therapeutically intervention on 55 patients the recovery has been observed, 42 patients didn't present relapse symptoms, 5 patients presented precocious relapse (under 12 months), respectively 6 patients presented tardy relapse (after 12 months).


CONCLUSIONS
The factors for favorable prognosis were: histology with lymphocyte prevalence, stage I or II without systemic signs (FFS 96%), primary localization of disease on one or two groups of ganglions, without hilar and mediastinal zones.
Universităţii de Medicină şi Farmacie Gr. T. Popa Iaşi Centrul Medical Providenţa Iaşi.
Irina
I
Efrosă
Ingrid
I
Miron
I
I
Tansanu
D000293:Adolescent; D017024:Chemotherapy, Adjuvant / Q000379:methods; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D015994:Incidence; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D016019:Survival Analysis; D016896:Treatment Outcome