[Fibrocystic breast disease--breast cancer sequence].
Fibrocystic breast disease has developed a major issue: the breast cancer sequence. Its involvement regarding the increse of breast cancer risk has 2 aspects: it may be either the marker of a prone tissue or a premalignant hystological deffect. Difficult differential diagnosis of benign proliferative breast lession and carcinoma led to the idea of sequency between the two: cancer does not initiate on normal mammary epithelia; it takes several proliferative stages for it to occur. In our series we analized a number of 677 breast surgical procedures where the pathologic examination reveals 115 cases (17%) of coexistence between cancer and fibrocystic breast disease. This aspect has proved to be related to earlier debut of breast cancer, suggesting that epithelial hyperplasia is a risk factor for breast cancer.
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Clinica Chirurgie I, Spitalul Clinic Judeţean de Urgency, Târgu-Mureş. vasilehab@yahoo.com
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D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000150:complications* / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000150:complications* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology