Cardiac: is this biomarker ready for the prime time?
Today, the increase of the blood concentration of cardiac troponins is designated as surrogate for cardiac necrosis and myocardial infarction, when an appropriate clinical and/or instrumental situation is present. As cardiac troponins reflect myocyte death, biomarkers of reversible myocardial damage in the absence of necrosis are, however, still needed to detect the presence of damage even before the irreversible injury is induced and identify "vulnerable" patients before major events occur, permitting adequate treatment. Markers of plaque destabilization and/or markers of myocardial ischemia could be enormously valuable in the emergency department setting if shown to contribute additional independent diagnostic information. However, a new cardiac biomarker is of definitive clinical value only if adequate assays for its measurement are available, its predictive value is defined in the right clinical context, optimal cut-off and release kinetics are known, demonstration of the marker incremental value is clear, there is consistency of marker performance across different settings, and, more importantly, there are data on the effect on patient management and outcome and on cost-effectiveness. Despite the emergence of multiple candidates, sufficient evidence for any of these has yet been demonstrated to recommend their adoption into clinical practice.
Department of Clinical Sciences Luigi Sacco, University of Milan, Milan, Italy. mauro.panteghini@unimi.it
Mauro
M
Panteghini
D054058:Acute Coronary Syndrome / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism*; D002624:Chemistry, Clinical / Q000191:economics / Q000379:methods* / Q000592:standards; D002637:Chest Pain / Q000378:metabolism / Q000473:pathology; D003362:Cost-Benefit Analysis; D006331:Heart Diseases / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009195:Peroxidase / Q000378:metabolism; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000378:metabolism; D014336:Troponin / Q000378:metabolism*
D015415:Biomarkers; D012709:Serum Albumin; D014336:Troponin; D009195:Peroxidase