The effect of tegaserod on symptoms and quality of life in korean women with irritable bowel syndrome with constipation.
BACKGROUND
Tegaserod has been used for treatment of irritable bowel syndrome (IBS) but there is no data regarding its effect on Korean patients. The aim of this study was to evaluate the effect of tegaserod on symptoms and quality of life (QOL) in Korean female IBS patients with constipation and to evaluate the usefulness of the IBS-QOL in clinical study.


METHODS
A prospective, open labeled, multicenter study was performed. Female patients fulfilling Rome II criteria for IBS received 6 mg of tegaserod twice a day for 4 weeks. The efficacy on IBS symptoms and QOL was assessed using 7-point scaled symptom questionnaire and IBS-QOL questionnaire, respectively.


RESULTS
A total of 81 female patients (range 18-73 years of age) were enrolled in this study. Tegaserod therapy significantly reduced the overall symptom scores after 4 weeks (p <0.01). The improved symptoms included abdominal discomfort or pain, hard or lumpy stool, straining during a bowel movement, feeling of incomplete bowel movement, and abdominal fullness or bloating. The IBS-QOL of responders to tegaserod treatment was also significantly improved after 4 weeks (p <0.01). Furthermore, improvement of symptom scores significantly correlated with improvement of the IBS-QOL scores (r = -0.60, p <0.001).


CONCLUSIONS
Tegaserod 6 mg given twice daily improved the QOL as well as the bowel symptoms in Korean female IBS patients with constipation. The IBS-QOL can be used as a reliable end-point in clinical study.
Kim
Yong Sung
YS
Wonkwang University College of Medicine, Iksan, Jeollabuk-do, Korea.
Choi
Suck Chei
SC
Park
Jae Myung
JM
Choi
Chang Hwan
CH
Lee
Dong Ho
DH
Son
Hee Jung
HJ
Sung
In Kyung
IK
Jeong
Jeong Jo
JJ
Lee
Joon Seong
JS
Shim
Ki Nam
KN
Lee
Kwang Jae
KJ
Hong
Su Jin
SJ
Choi
Myung-Gyu
MG