Metal-catalyzed direct alkylations of (hetero)arenes via C-H bond cleavages with unactivated alkyl halides.
Significant progress has been made in direct alkylations of (hetero)arenes with unactivated alkyl halides. Thus, C-H bond functionalizations were accomplished with beta-hydrogen-containing alkyl halides in the presence of palladium, nickel or ruthenium catalysts under basic reaction conditions. A valuable asset of these methodologies is represented by their excellent regio- and chemoselectivities, along with remarkable mild reaction conditions, rendering this approach an attractive alternative to traditional alkylation strategies.
Ackermann
Lutz
L
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de
D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
D006219:Halogens; D008670:Metals; D010165:Palladium; D002244:Carbon; D009532:Nickel; D012428:Ruthenium; D006859:Hydrogen