[Risk factors involved in multiresistant infections with strains of Enterobacteriaceae].
OBJECTIVE
The present study aims to analyse the risk factors involvement in the cross infectious pathology determined by multiresistant Enterobacteriaceae, in hospitalised patients in the Intensive Care Unit at the County Emergency Clinical Hospital in Timişoara.


METHODS
We carried out a case-control study with 3 groups of adult inpatients--200 patients with no superadded infectious pathology, 100 patients infected with Enterobacteriaceae strains resistant to 3 classes of antibacterial chemotherapeutic agents and 100 infected with multiresistant strains. Identification of bacterial germs was performed using API ID 20 E manual galleries (BioMérieux) and the inclusion in the resistance phenotypes was done using the Osiris Evolution (BioRad) analyser.


RESULTS
Subjects infected with multiresistant strains are mostly male, (p=0.020, OR=1.8 [1.06-3.07], RR=1.49, [1.05-2.11]), with the mean age younger than that of the control group (p=0.011). The mean Charlson Comorbidity Index was 3.34 in Group III and 4.06 in Group I (p=0.027). The logistic regression application keeps as well as independent risk factors for multiresistance--the mechanical ventilation, consciousness impairment, prolonged hospitalization and the higher number of days of antibiotherapy.


CONCLUSIONS
In this study, the nosocomial factors and basic pathology prevail to the detriment of other intrinsic risk factors.
Disciplina de Epidemiologie, Universitatea de Medicină şi Farmacie "Victor Babeş" Timişoara.
Luminiţa
L
Bădiţoiu
Monica
M
Licker
E D
ED
Popovici
Delia Berceanu
DB
Văduva
Liliana
L
Dragomirescu
Ramona
R
Pîrvan
Delia
D
Muntean
F
F
Horhat
Roxana
R
Moldovan
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016022:Case-Control Studies; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D052978:Disk Diffusion Antimicrobial Tests; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D012044:Regression Analysis; D012307:Risk Factors
D000900:Anti-Bacterial Agents