Micro-/nano-patterning of DNA and rapid readout with SERS tags.
Hybridisation of oligonucleotide micro- and nano-structures, formed using far- and near-field optical lithography, with Raman dye-labelled silver nanoparticles functionalised with complementary oligonucleotides yields striking contrast, attributed to Raman "hot-spot" formation, and enables rapid, convenient read-out by Raman microscopy.
National Center for Nanoscience and Technology, Beijing 100190, China. sunsq@nanoctr.cn
Shuqing
S
Sun
David
D
Thompson
Ute
U
Schmidt
Duncan
D
Graham
Graham J
GJ
Leggett
D004247:DNA / Q000032:analysis* / Q000737:chemistry; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods*
D004247:DNA