Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004.
Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1%) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.
Cho
Mee-Yon
MY
Department of Pathology, Wonju College of Medicine Yonsei University, Wonju, Korea.
Sohn
Jin Hee
JH
Kim
Joon Mee
JM
Kim
Kyoung-Mee
KM
Park
Young Su
YS
Kim
Woo Ho
WH
Jung
Jin Sook
JS
Jung
Eun Sun
ES
Jin
So-Young
SY
Kang
Dae Young
DY
Park
Jae Bok
JB
Park
Ho Sung
HS
Choi
You Duck
YD
Sung
Sun Hee
SH
Kim
Young-Bae
YB
Kim
Hogeun
H
Bae
Young-Kyung
YK
Kang
Miseon
M
Chang
Hee Jin
HJ
Chae
Yang Seok
YS
Lee
Hee Eun
HE
Park
Do Youn
DY
Lee
Youn Soo
YS
Kang
Yun Kyung
YK
Kim
Hye Kyung
HK
Chang
Hee-Kyung
HK
Hong
Soon Won
SW
Choi
Young Hee
YH
Shin
Okran
O
Gu
MiJin
M
Kim
Youn Wha
YW
Kim
Gwang Il
GI
Chang
Sei Jin
SJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D009418:S100 Proteins / Q000378:metabolism; D012737:Sex Factors; D016019:Survival Analysis
D018952:Antigens, CD34; D009418:S100 Proteins