Sulfur-adlayer-coated gold electrode for the in vitro electrochemical detection of uric acid in urine.
The present article demonstrates the electrochemical oxidation of uric acid (UA) at sulfur-adlayer-coated gold (S-Au) electrode in alkaline media. At S-Au electrode, UA oxidized at a significantly lower overpotential with a higher current density as compared to the bare Au electrode. The oxidation of UA at the S-Au electrode is highly selective in the presence of the other commonly existing bio-molecules in urine. The proposed electrochemical sensor not only exhibited good reproducibility, but also showed a fast amperometric response to UA in the concentration range of 0.0025-5 mM with a low detection limit of 0.4 microM.
Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Mail Box G1-5, 4259 Nagastuta, Midori-ku, Yokohama 226-8502, Japan. mrmche@yahoo.com
Md Rezwan
MR
Miah
Muhammad Tanzirul
MT
Alam
Takeo
T
Ohsaka
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D006046:Gold; D006801:Humans; D057230:Limit of Detection; D015203:Reproducibility of Results; D013455:Sulfur; D014527:Uric Acid / Q000652:urine
D014527:Uric Acid; D013455:Sulfur; D006046:Gold