Restoration of Guyton´s diagram for regulation of the circulation as a basis for quantitative physiological model development.
We present the current state of complex circulatory dynamics model development based on Guyton's famous diagram. The aim is to provide an open-source model that will allow the simulation of a number of pathological conditions on a virtual patient including cardiac, respiratory, and kidney failure. The model will also simulate the therapeutic influence of various drugs, infusions of electrolytes, blood transfusion, etc. As a current result of implementation, we describe a core model of human physiology targeting the systemic circulation, arterial pressure and body fluid regulation, including short- and long-term regulations. The model can be used for educational purposes and general reflection on physiological regulation in pathogenesis of various diseases.
Kofránek
J
J
Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic.
Rusz
J
J
D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001826:Body Fluids / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D049490:Systems Biology