Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.
Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT(1B) and 5-HT(1D) receptors in macaques and rats. In the inner ear, 5-HT(1B) and 5-HT(1D) receptor immunopositivity was associated with endothelial cells of the vestibular ganglion, spiral ganglion, vestibulocochlear nerve, spiral ligament and stria vascularis. It was noteworthy that 5-HT(1B) and 5-HT(1D) receptors are expressed in parallel sites in peripheral vestibular and trigeminal systems, which may be a factor underlying the efficacy of triptans in treating migraine and migrainous vertigo. Because the vestibular ganglion and trigeminal ganglion are both within the subarachnoid space, an interaction between 5-HT(1B) and TRPV1 receptors on blood vessel and ganglion cells may also contribute to the vasospasm and the comorbid headache, dizziness, nausea and vomiting that accompany subarachnoid hemorrhage.
Ahn
Seong-Ki
SK
Department of Otolaryngology, School of Medicine, Gyeongsang National University, and University Hospital Jinju, Korea.
Balaban
Carey D
CD
D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism; D003627:Data Interpretation, Statistical; D007758:Ear, Inner / Q000378:metabolism*; D007150:Immunohistochemistry; D008253:Macaca mulatta; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D044346:Receptor, Serotonin, 5-HT1D / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism; D014363:Tryptamines / Q000494:pharmacology
D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D014363:Tryptamines