Characterization of pseudacyclins A-E, a suite of cyclic peptides produced by Pseudallescheria boydii.
Pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. In this work, two P. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pseudallescheria species.
Institute of Microbiology, Videnska 1083, 142 20 Prague 4, Czech Republic.
Katerina
K
Pavlaskova
Jan
J
Nedved
Marek
M
Kuzma
Martin
M
Zabka
Miroslav
M
Sulc
Jan
J
Sklenar
Petr
P
Novak
Oldrich
O
Benada
Olga
O
Kofronova
Marian
M
Hajduch
Peter J
PJ
Derrick
Karel
K
Lemr
Alexandr
A
Jegorov
Vladimir
V
Havlicek
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D011541:Pseudallescheria / Q000737:chemistry* / Q000472:pathogenicity
D010456:Peptides, Cyclic