Laboratorial atopy markers in children with human immunodeficiency virus.
Changes in immune system functions are one of the most important consequences of human immunodeficiency virus (HIV) infection. Studies have reported a higher prevalence of disease mediated by immunological hypersensitivity mechanisms in HIV-positive patients. This study aims to observe how immunological changes in HIV-infected children interfere in atopy determinants. Fifty-seven HIV-positive children were studied between June 2004-August 2005 to evaluate the possible modifications in atopy diagnosis from prick test environmental allergen reactivity. Patients were subjected to two evaluations: on both occasions, atopic and non-atopic groups were correlated with immunological (CD4+ and CD8+ lymphocyte concentrations and serum levels of IgA, IgM, IgG and IgE) and viral parameters (HIV viral load). The percent atopy was 20.05 in the first and 29.82 in the second evaluation and atopy was diagnosed in patients without immunosuppression or with moderate immunosuppression. Six patients changed from a negative to a positive atopy profile. One patient with a decreased CD4+ T lymphocyte concentration failed to demonstrate prick test positivity between evaluations. Multivariate analysis showed that the variables associated with atopy diagnosis included a personal history of allergic diseases as well as elevated IgE for age and elevated IgE levels. Atopy development in HIV-infected children seems to be modulated by genetic and environmental factors as well as immunological condition.
Departamento de Pediatria, Universidade Federal do Paraná, Curitiba, PR, Brasil. criscruz@ufpr.br
Cristina Rodrigues
CR
Cruz
Vania Oliveira
VO
Carvalho
Rosaly Vieira
RV
Santos
Tony Tannous
TT
Tahan
Andrea Maciel Oliveira
AM
Rossoni
Hermenio Cavalcante
HC
Lima
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D007132:Immunoglobulin Isotypes / Q000097:blood*; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012882:Skin Tests; D019562:Viral Load
D015415:Biomarkers; D007132:Immunoglobulin Isotypes