Stereocontrolled synthesis of trans-cyclopropyl sulfones from terminal epoxides.
Treatment of a range of (enantiopure) epoxides with the sodium salt of diethyl (phenylsulfonyl)methylphosphonate in DME at 140 degrees C for 4 h gives a variety of (enantiopure) trans-cyclopropyl sulfones with high diastereoselectivity.
Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London E1 4NS, UK. c.bray@qmul.ac.uk
Christopher D
CD
Bray
Giorgio
G
de Faveri
D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry*
D003521:Cyclopropanes; D004852:Epoxy Compounds; D013450:Sulfones