The quest to understand heterotrimeric G protein signaling.
Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.
Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA. tesmerjj@umich.edu
John J G
JJ
Tesmer
D000818:Animals; D006160:Guanosine Triphosphate / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism; D012243:Rhodopsin / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D043562:Receptors, G-Protein-Coupled; D006160:Guanosine Triphosphate; D012243:Rhodopsin; D020962:Heterotrimeric GTP-Binding Proteins