[Importance of determination of C reactive protein (CRP), carcinoembryonic antigen (CEA) and lactic dehydrogenase (LDH) in colorectal cancer].
OBJECTIVE
Evaluate and show the importance of CRP, ACE and LDH in colorectal cancer.


METHODS
Our prospective study interested 30 patients, from 26 to 93 years old and present a colorectal cancer, confirmed histologically, during the period going from March 2003 to April 2004, and 30 healthy controls. A blood sample was collected from each patient respectively in preoperative, 48 hours before any treatment, and 6 months after surgical operation to measure serum LDH, CRP, and ACE.


RESULTS
The mean serum of LDH, CRP and ACE values were significant higher in patients than those in controls (p respectively: 0,01; 0,04 et 0,01). Moreover, the level of three parameters varied significantly with stages of tumor. After follow up, we have noticed e normalisation of the mean of the level of LDH, CRP and ACE with favorable evolution. Analysis of survival at 2 years showers that survival is better in patients with normal value of CRP, ACE and LDH.


CONCLUSIONS
CRP, LDH and ACE values have a great importance during follows up after colorectal cancer surgery.
Service de Biologie Clinique, Institut Salah Azaiz, Tunis.
Hajer
H
Abaza
Abderraouf
A
Ghanem
Aouatef
A
Jmal
Hamouda
H
Boussen
Latifa
L
Harzallah
Khaled
K
Rahal
Fethi
F
Guemira
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase