Brain microdialysis study of meropenem in two patients with acute brain injury.
Concentrations of unbound meropenem in the cerebral extracellular fluid (ECF) of two patients with acute brain injury were assessed by microdialysis. Brain ECF unbound-meropenem concentrations were lower than serum unbound-meropenem concentrations, with brain-to-serum area under the concentration-time curve ratios of 0.73 and 0.14. A pharmacokinetic model was developed to fit the experimental data adequately.
Université de Poitiers, CHU de Poitiers and INSERM ERI-23, Pôle Biologie Santé (PBS), Médecine-Sud, Niveau 1, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France.
Claire
C
Dahyot-Fizelier
Ivan
I
Timofeev
Sandrine
S
Marchand
Peter
P
Hutchinson
Bertrand
B
Debaene
David
D
Menon
Olivier
O
Mimoz
Arun
A
Gupta
William
W
Couet
D000328:Adult; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000150:complications*; D045604:Extracellular Fluid / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008171:Lung Diseases / Q000188:drug therapy*; D008297:Male; D000077731:Meropenem; D017551:Microdialysis / Q000379:methods*; D013845:Thienamycins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
D013845:Thienamycins; D000077731:Meropenem