Recurrent acute obstructive hydrocephalus as clinical onset of cerebral Whipple's disease.
Whipple's disease is a rare multisystemic infection caused by the intracellular bacteria Thropheryma whippelii. Central nervous system (CNS) involvement is not rare. The most frequent CNS manifestations are cognitive and behavioural changes, sopranuclear ophtalmoplegia, myoclonus, epilepsy, ataxia, meningitis and focal cerebral palsy. We report one case of cerebral localization of Whipple's disease with a clinical presentation of recurrent endocranic hypertension and hydrocephalus, and uncommon neurological symptoms, successfully treated by endoscopic third ventriculostomy and antibiotic therapy with ceftriaxone and Trimethoprim-Sulfamethoxazole.
Department of Neurological Sciences, Center of Excellence for Technological Innovation in Surgery ITC, Section of Neurosurgery, Federico II University School of Medicine, Naples, Italy.
Vincenzo
V
Seneca
Alessia
A
Imperato
Giuseppe
G
Colella
Valentina
V
Cioffi
Giuseppe
G
Mariniello
Michelangelo
M
Gangemi
D000208:Acute Disease; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D058565:Cerebral Ventriculitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D004359:Drug Therapy, Combination; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000382:microbiology; D019586:Intracranial Hypertension / Q000209:etiology* / Q000382:microbiology; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome; D014696:Ventriculostomy; D008061:Whipple Disease / Q000150:complications* / Q000188:drug therapy
D000890:Anti-Infective Agents