Does pulmonary function change during whole-body deep hypothermia?
Whole-body deep hypothermia (DH) could be a new therapeutic strategy for asphyxiated newborn. Aim of this study was to describe how DH (core temperature 30-33°C) modifies the respiratory function if compared with mild hypothermia (MH; core temperature 33-34°C). This is an observational study. Results were obtained from a pilot study of safety of DH and topiramate in neonatal hypoxic-ischaemic encephalopathy. Fifty-seven newborns were enrolled: 29 patients in DH and 28 in MH. Recruitment criteria were moderate-severe hypoxic-ischaemic encephalopathy and gestational age ≥36 weeks. Mechanical ventilation was set to maintain SaO(2) between 92% and 95%. Nineteen patients in DH and 18 in MH required mechanical ventilation. Of these patients, 10 and 12, respectively, did not required oxygen. No significant differences were observed in hours of oxygen and ventilation support, respiratory rate and PaCO(2). Maximum FiO(2), peak inspiratory pressure, positive end-expiratory pressure, minute ventilation and tidal volume during hypothermia were similar. Pulmonary function with different levels of hypothermia was similar.
Cavallaro
Giacomo
G
Neonatal Intensive Care Unit, Fondazione IRCCS Cà' Granda-Ospedale Maggiore Policlinico, University Department of Mother and Infant Sciences, University of Milan, Milan, Italy. giacomo.cavallaro@mangiagalli.it
Filippi
Luca
L
Cristofori
Gloria
G
Colnaghi
Mariarosa
M
Ramenghi
Luca
L
Agazzani
Elisa
E
Ronchi
Andrea
A
Fiorini
Patrizio
P
Mosca
Fabio
F
D001831:Body Temperature / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D003131:Combined Modality Therapy; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology*; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D010313:Partial Pressure; D010865:Pilot Projects; D012121:Respiration, Artificial / Q000379:methods; D056152:Respiratory Rate / Q000502:physiology; D012189:Retrospective Studies; D000077236:Topiramate
D018696:Neuroprotective Agents; D000077236:Topiramate; D002245:Carbon Dioxide; D005632:Fructose; D010100:Oxygen