Non-Langerhans histiocytosis mimicking sarcoidosis on high-resolution computed tomography.
The non-Langerhans histiocytoses (NLH) are a group of very rare disorders characterized by a predominantly cutaneous proliferation of non-Langerhans histiocytes. Involvement of the respiratory system is rare and more frequently affects the airways than the lung parenchyma. We describe a 44-year-old man with the progressive nodular form of NLH, with known cutaneous and hepatic involvement. High-resolution computed tomography performed for the investigation of his breathlessness revealed an interstitial pattern of disease closely resembling sarcoidosis. Lung biopsy showed non-Langerhans histiocytic infiltration of the lung parenchyma. Radiologists should be aware of NLH as a mimic of pulmonary sarcoidosis.
Department of Radiology, Imperial Healthcare NHS Trust, London, UK.
Claire R
CR
Lloyd
Andrew G
AG
Nicholson
Athol U
AU
Wells
David M
DM
Hansell
D000328:Adult; D003937:Diagnosis, Differential; D015616:Histiocytosis, Non-Langerhans-Cell / Q000000981:diagnostic imaging*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D012507:Sarcoidosis; D014057:Tomography, X-Ray Computed / Q000379:methods*