FoXS: a web server for rapid computation and fitting of SAXS profiles.
Small angle X-ray scattering (SAXS) is an increasingly common technique for low-resolution structural characterization of molecules in solution. SAXS experiment determines the scattering intensity of a molecule as a function of spatial frequency, termed SAXS profile. SAXS profiles can contribute to many applications, such as comparing a conformation in solution with the corresponding X-ray structure, modeling a flexible or multi-modular protein, and assembling a macromolecular complex from its subunits. These applications require rapid computation of a SAXS profile from a molecular structure. FoXS (Fast X-Ray Scattering) is a rapid method for computing a SAXS profile of a given structure and for matching of the computed and experimental profiles. Here, we describe the interface and capabilities of the FoXS web server (http://salilab.org/foxs).
Schneidman-Duhovny
Dina
D
Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, CA 94158, USA.
Hammel
Michal
M
Sali
Andrej
A
D020407:Internet; D053838:Scattering, Small Angle; D012984:Software; D014584:User-Computer Interface; D014961:X-Ray Diffraction