Anticancer activity of andrographolide semisynthetic derivatives.
Andrographolide 1, a diterpene lactone of Andrographis paniculata, displays in vitro and in vivo antitumor activity against breast cancer models and mouse myeloid leukemia (M1) cells. In the present study, we report the semi-synthesis of andrographolide derivatives and their in vitro activity against A549 (ATCC) (NSCL cancer) cell line. Amongst the derivatives tested, compounds 3-5 displayed maximum activity, with IC50 values of 22-31 microg/mL.
Menon
Vidya
V
Laboratory for Advanced Research in Natural and Synthetic Chemistry, V. G. Vaze College, Mumbai University, Mithagar road, Mulund (East), Mumbai 400 081, India.
Bhat
Sujata
S
D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C030419:andrographolide