Overexpression of KLF13 and FGFR3 in oral cancer cells.
KLF13 and FGFR3 have important cellular functions and each is believed to play a role in cancer. KLF13 is a transcription factor required for the expression of several oncogenes. FGFR3 is a fibroblast growth factor receptor that initiates a signaling cascade leading to the activation of numerous cellular pathways. Here we show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cancer cells and may be useful biomarkers for early detection and possible targets for therapy.
Henson
B J
BJ
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
Gollin
S M
SM
D000328:Adult; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics*; D002454:Cell Differentiation; D002455:Cell Division; D045744:Cell Line, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D009367:Neoplasm Staging; D011839:Radiation, Ionizing; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; C486423:KLF13 protein, human; D051741:Kruppel-Like Transcription Factors; D012097:Repressor Proteins; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3