Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.
Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrollment, current use of estrogen-only (HR, 1.02; 95% CI, 0.79-1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77-1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen-only or estrogen plus progestin therapy with colorectal cancer risk.
Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. kostas.tsilidis@ceu.ox.ac.uk
Konstantinos K
KK
Tsilidis
Naomi E
NE
Allen
Timothy J
TJ
Key
Miguel A
MA
Sanjoaquin
Kjersti
K
Bakken
Franco
F
Berrino
Agnès
A
Fournier
Eiliv
E
Lund
Kim
K
Overvad
Anja
A
Olsen
Anne
A
Tjønneland
Graham
G
Byrnes
Veronique
V
Chajes
Sabina
S
Rinaldi
Marie-Christine
MC
Boutron-Ruault
Francoise
F
Clavel-Chapelon
Jenny
J
Chang-Claude
Rudolf
R
Kaaks
Manuela
M
Bergmann
Heiner
H
Boeing
Yvoni
Y
Koumantaki
Domenico
D
Palli
Valeria
V
Pala
Salvatore
S
Panico
Rosario
R
Tumino
Paolo
P
Vineis
H
H
Bas Bueno-de-Mesquita
Fränzel J B
FJ
van Duijnhoven
Carla H
CH
van Gils
Petra H M
PH
Peeters
Laudina
L
Rodríguez
Carlos A
CA
González
María-José
MJ
Sánchez
Maria-Dolores
MD
Chirlaque
Aurelio
A
Barricarte
Miren
M
Dorronsoro
Kay-Tee
KT
Khaw
Sheila A
SA
Rodwell
Teresa
T
Norat
Dora
D
Romaguera
Elio
E
Riboli
D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D052756:Nutritional Sciences; D017698:Postmenopause; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D044465:White People