Polymeric ethyl glyoxylate in an asymmetric aldol reaction catalyzed by diarylprolinol.
Diarylprolinol was found to be an effective organocatalyst of the direct, enantioselective aldol reaction of commercially available polymeric ethyl glyoxylate, affording gamma-ethoxycarbonyl-beta-hydroxy aldehydes, versatile synthetic intermediates, in good yield with excellent enantioselectivity.
Urushima
Tatsuya
T
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Yasui
Yusuke
Y
Ishikawa
Hayato
H
Hayashi
Yujiro
Y
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006038:Glyoxylates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D006038:Glyoxylates; D011108:Polymers; D011759:Pyrrolidines; C010509:prolinol