Opioid detoxification: from controlled clinical trial to clinical practice.
Controlled clinical trials have high internal validity but suffer from difficulties in external validity. This study evaluates the generalizability of the results of a controlled clinical trial on rapid detoxification in the everyday clinical practice of two addiction treatment centers. The results show that rapid detoxification in everyday practice differs with regard to patient characteristics, enrolment, and completion rates (86.8% vs. 100%). However, abstinence rates after rapid detoxification in the controlled clinical trial (61.8%) were generalizable to everyday clinical practice (59.0%). Implementation factors that may have influenced the results, such as referral problems and treatment delivery, are discussed.
Novadic-Kentron, Network for Addiction Treatment Services, Vught, The Netherlands. boukje.dijkstra@novadic-kentron.nl
Boukje A G
BA
Dijkstra
Cor A J
CA
De Jong
Michel
M
Wensing
Paul F M
PF
Krabbe
Cees P F
CP
van der Staak
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D015203:Reproducibility of Results; D016320:Substance Abuse Treatment Centers / Q000379:methods*
D009292:Narcotic Antagonists; D009271:Naltrexone