Methylphenidate transdermal system in adults with past stimulant misuse: an open-label trial.
OBJECTIVE
This 8-week, open-label trial assessed the efficacy of methylphenidate transdermal system (MTS) in 14 adult individuals diagnosed with ADHD and with a history of stimulant misuse, abuse, or dependence.


METHODS
The primary efficacy endpoint was the Wender-Reimherr Adult ADHD Scale (WRAADS), and secondary efficacy endpoints included the Clinical Global Impression (CGI) ratings and substance abuse as quantified by urine drug screens and self-reported use.


RESULTS
Significant improvements from baseline were found on both the WRAADS and CGI measurements. No abuse of the study medication was observed.


CONCLUSIONS
The findings suggested that MTS may improve ADHD symptoms in adults with a history of stimulant misuse; however, there were limitations. The study data showed the need for subsequent randomized studies that further explore findings made in this study.
McRae-Clark
Aimee L
AL
Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA. mcraeal@musc.edu
Brady
Kathleen T
KT
Hartwell
Karen J
KJ
White
Kathleen
K
Carter
Rickey E
RE
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D019969:Amphetamine-Related Disorders / Q000150:complications / Q000175:diagnosis*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
D000697:Central Nervous System Stimulants; D008774:Methylphenidate