Microwave-assisted copper(II)-catalyzed one-pot four-component synthesis of multifunctionalized dihydropyridines.
A fast and highly efficient copper-catalyzed multicomponent synthesis of 1,4-dihydropyridines under microwave irradiation is described. The protocol utilizes mild reaction conditions with low catalytic loading, leading to high yields. This methodology provides us with biologically active 1,4-dihydropyridine library for medicinal chemistry applications.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical, Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Kalyan Kumar
KK
Pasunooti
Chantel
C
Nixon Jensen
Hua
H
Chai
Min Li
ML
Leow
Da-Wei
DW
Zhang
Xue-Wei
XW
Liu
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D004095:Dihydropyridines; D054852:Small Molecule Libraries; D003300:Copper