Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells.
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.
Department of Biological Science, China Medical University, Taichung, Taiwan, ROC.
Yuan-Man
YM
Hsu
Chih-Ho
CH
Lai
Chiu-Hsiang
CH
Su
Wei-Wen
WW
Kuo
Chao-Lin
CL
Kuo
Cheng-Kuang
CK
Hsu
Chien-Kuo
CK
Wang
Ching-Yao
CY
Chang
Jing-Gung
JG
Chung
D000230:Adenocarcinoma / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000473:pathology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D032322:Solanum / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
D010936:Plant Extracts