Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition.
BACKGROUND
Small intestine essentially regulates cholesterol homeostasis.


OBJECTIVE
To evaluate cholesterol metabolism in short bowel syndrome (SBS).


METHODS
Cholesterol precursors (e.g., cholestenol, desmosterol and lathosterol) and plant sterols (campesterol and sitosterol), respective markers of cholesterol synthesis and absorption, were determined in SBS patients (n=12) an average of 31 months after weaning off parenteral nutrition and in age-matched controls (n=80).


RESULTS
Among patients, serum cholesterol precursor sterol to cholesterol ratios were 2-10 times higher (P<0.0001 for each). Those without any remaining ileum had 1.2-2.8 times higher precursor sterol to cholesterol ratios than those with an ileal remnant (P<0.05 for each). Serum cholesterol concentration, campesterol/cholesterol and campesterol/sitosterol were 34-39% lower (P<0.05 for each) in relation to controls. Bile acid absorption was markedly impaired (2.4 (0.2-3.2)%). Plant sterol ratios reflected the absolute length of remaining jejunum (r=0.625-0.663), and precursor sterol ratios inversely that of ileum (r=-0.589 to 0.750, P<0.05 for all).


CONCLUSIONS
After weaning off parenteral nutrition, patients with pediatric onset SBS continue to have marked intestinal malabsorption of bile acids and moderate cholesterol malabsorption resulting in decreased serum cholesterol despite a marked compensatory increase in cholesterol synthesis.
Section of Pediatric Surgery, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. mikko.pakarinen@hus.fi
Mikko P
MP
Pakarinen
Annika
A
Kurvinen
Helena
H
Gylling
Tatu A
TA
Miettinen
Maria
M
Pesonen
Markku
M
Kallio
Antti I
AI
Koivusalo
Markku J
MJ
Nissinen
D001647:Bile Acids and Salts / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood*; D003897:Desmosterol / Q000097:blood; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008286:Malabsorption Syndromes / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D010288:Parenteral Nutrition; D010840:Phytosterols / Q000097:blood; D012778:Short Bowel Syndrome / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013261:Sterols / Q000097:blood; D013997:Time Factors
D001647:Bile Acids and Salts; D010840:Phytosterols; D013261:Sterols; D003897:Desmosterol; C001521:lathosterol; D002784:Cholesterol