Ichthyotic-appearing skin changes associated with childhood morphea, systemic sclerosis, and systemic lupus erythematosus/scleroderma overlap.
Ichthyotic-appearing skin changes have been associated with autoimmune disorders, including systemic lupus erythematosus and systemic sclerosis in adults. We report three children with ichthyotic-appearing skin changes that may be an early feature reflecting underlying dermal sclerosis. Detection of these subtle skin changes may be predictive of more widespread cutaneous involvement, ultimately prompting earlier treatment.
Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
Christy M
CM
Williams
Craig A
CA
Storm
Christopher
C
Burns
William
W
Rigby
James G H
JG
Dinulos
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007057:Ichthyosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D019808:Losartan / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D000077402:Pantoprazole; D011239:Prednisolone / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D006886:Hydroxychloroquine; D011239:Prednisolone; D000077402:Pantoprazole; D019808:Losartan