Reactive vascular lesions treated using ethanolamine oleate sclerotherapy.
BACKGROUND
Ethanolamine oleate (EO) is used infrequently in dermatology, but is used to treat vascular lesions such as esophageal varices, varicose veins, and congenital vascular malformations.


OBJECTIVE
To evaluate the efficacy and safety of EO for treating reactive vascular lesions.


METHODS
Patients with reactive vascular lesions, such as pyogenic granulomas or venous lakes, were enrolled. EO was used as a sclerosing agent in a 1:1 dilution with normal saline. According to the response, treatment was repeated with EO with less or no dilution. The treatment response was scored as complete remission (CR), moderate improvement (MI), or no change according to the clinical results; any side effects were recorded.


RESULTS
The efficacy of EO was evaluated in 21 patients (16 pyogenic granulomas and 5 venous lakes). The diameters of the lesions ranged from 0.3 to 1.0 cm. The mean number of EO injections was 1.6 (range 1-4). A CR was achieved in 95% of the reactive vascular lesions (20 CR, 1 MI). Two episodes of transient pain occurred.


CONCLUSIONS
EO is an excellent sclerosing agent for treating reactive vascular lesions, and it may be an alternative therapy for vascular lesions in dermatology.
Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busanjin-gu, Busan, Korea.
Soon-Kwon
SK
Hong
Hyun-Jae
HJ
Lee
Jong-Keun
JK
Seo
Deborah
D
Lee
Seon-Wook
SW
Hwang
Ho-Suk
HS
Sung
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D005260:Female; D017789:Granuloma, Pyogenic / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000008:administration & dosage*; D012189:Retrospective Studies; D012597:Sclerosing Solutions / Q000008:administration & dosage*; D015911:Sclerotherapy; D012871:Skin Diseases / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000473:pathology / Q000628:therapy*; D055815:Young Adult
D009829:Oleic Acids; D012597:Sclerosing Solutions; C033343:ethanolamine oleate