Congenital acute myeloid leukemia with t(8;16) and t(17;19) double translocation: case presentation and literature review.
Congenital leukemia is uncommon and excluding transient myeloproliferation associated with Down syndrome, makes up approximately 1% of childhood leukemias. A newborn boy was born with multiple subcutaneous nodules and large purpuric papules. Skin biopsy revealed proliferation of atypical hematologic cells in the dermis. Bone marrow morphology was consistent with acute myeloid leukemia (M5) and cytogenetic studies revealed t(8;16) and t(17;19) double translocation. Although prognosis of congenital leukemia is known to be dismal, recent reports showed spontaneous remissions. With the fear of chemotherapy-related toxicity, to treat or not to treat may be a dilemma both to parents and pediatricians. We report our experience and review the literature.
Sung
Tae-Jung
TJ
Department of Pediatrics, College of Medicine, Hallym University Medical Center, Seoul, Korea. neosung@hallym.or.kr
Lee
Dae-Hyoung
DH
Kim
Soon-Ki
SK
Jun
Yong-Hoon
YH
D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic