Visiting the cell biology of Salmonella infection.
Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by countering the defense mechanism of the specific cell. In this review, we will summarize the recent insights into the cell biology of Salmonella infection. Here, we will focus on the findings that deal with the specific mechanism of various cell types to control Salmonella infection. Further, the survival strategies of the pathogen in response to the host immunity will also be discussed in detail. Better understanding of the mechanisms by which Salmonella evade the host defense system and establish pathogenesis will be critical in disease management.
Center for Infectious Disease Research and Biosafety Laboratories, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Amit
A
Lahiri
Ayan
A
Lahiri
Namrata
N
Iyer
Priyanka
P
Das
Dipshikha
D
Chakravortty
D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D050296:Microbial Viability; D012475:Salmonella / Q000276:immunology* / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000276:immunology* / Q000382:microbiology*