Ultrasound-assisted one-pot, four component synthesis of 4-aryl 3,4-dihydropyridone derivatives.
The condensation of Meldrum's acid, aromatic aldehydes, alkyl acetoacetates and ammonium acetate in glacial acetic acid under ultrasound irradiation at room temperature results in the formation of 3,4-dihydropyridone derivatives (4a-p) in 85-96% yields. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction times and higher yields.
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400-Ciudad Habana, Cuba.
Enrique
E
Ruiz
Hortensia
H
Rodríguez
Julieta
J
Coro
Esperanza
E
Salfrán
Margarita
M
Suárez
Roberto
R
Martínez-Alvarez
Nazario
N
Martín
D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014465:Ultrasonics
D011728:Pyridones