Organic synthesis using a hypervalent iodine reagent: unexpected and novel domino reaction leading to spiro cyclohexadienone lactones.
The reaction of 1-(p-hydroxyaryl)cyclobutanols and phenyl iodide(III) diacetate in hexafluoroisopropanol and water produced spiro cyclohexadienone lactones via a domino reaction.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. fujioka@phs.osaka-u.ac.jp
Hiromichi
H
Fujioka
Hideyuki
H
Komatsu
Taeko
T
Nakamura
Akihito
A
Miyoshi
Kayoko
K
Hata
Jnashuara
J
Ganesh
Kenichi
K
Murai
Yasuyuki
Y
Kita
D053138:Cyclohexenes / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D053138:Cyclohexenes; D007783:Lactones; D013141:Spiro Compounds; C507608:cyclohexadienone; D007455:Iodine