Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.
Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrollment, current use of estrogen-only (HR, 1.02; 95% CI, 0.79-1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77-1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen-only or estrogen plus progestin therapy with colorectal cancer risk.
Tsilidis
Konstantinos K
KK
Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. kostas.tsilidis@ceu.ox.ac.uk
Allen
Naomi E
NE
Key
Timothy J
TJ
Sanjoaquin
Miguel A
MA
Bakken
Kjersti
K
Berrino
Franco
F
Fournier
Agnès
A
Lund
Eiliv
E
Overvad
Kim
K
Olsen
Anja
A
Tjønneland
Anne
A
Byrnes
Graham
G
Chajes
Veronique
V
Rinaldi
Sabina
S
Boutron-Ruault
Marie-Christine
MC
Clavel-Chapelon
Francoise
F
Chang-Claude
Jenny
J
Kaaks
Rudolf
R
Bergmann
Manuela
M
Boeing
Heiner
H
Koumantaki
Yvoni
Y
Palli
Domenico
D
Pala
Valeria
V
Panico
Salvatore
S
Tumino
Rosario
R
Vineis
Paolo
P
Bas Bueno-de-Mesquita
H
H
van Duijnhoven
Fränzel J B
FJ
van Gils
Carla H
CH
Peeters
Petra H M
PH
Rodríguez
Laudina
L
González
Carlos A
CA
Sánchez
María-José
MJ
Chirlaque
Maria-Dolores
MD
Barricarte
Aurelio
A
Dorronsoro
Miren
M
Khaw
Kay-Tee
KT
Rodwell
Sheila A
SA
Norat
Teresa
T
Romaguera
Dora
D
Riboli
Elio
E
D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D052756:Nutritional Sciences; D017698:Postmenopause; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D044465:White People