Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms.
Vitamin D is essential for optimal bone health. Stress fracture is an overuse injury often occurring in active populations. Study results indicate an association exists between vitamin D status and the risk of stress fracture, and one intervention trial demonstrated a reduction in stress fractures in women consuming supplemental vitamin D and calcium. A recent study found that two polymorphisms in the vitamin D receptor (VDR), Fok1 and Bsm1, may increase the risk of stress fracture. Although further study is required, screening for VDR polymorphisms may become a tool for identifying individuals at increased risk of stress fracture during physical training.
McClung
James P
JP
Military Nutrition Division of the US Army Research Institute of Environmental Medicine (USARIEM), Natick, Massachusetts 01760, USA. James.McClung@amedd.army.mil
Karl
J Philip
JP
D005260:Female; D015775:Fractures, Stress / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008297:Male; D009752:Nutritional Status; D010809:Physical Fitness; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D014807:Vitamin D / Q000502:physiology*
D018167:Receptors, Calcitriol; D014807:Vitamin D