Inflammation and dyslipidaemia: a possible interplay between established risk factors in North Indian males with coronary artery disease.
OBJECTIVE
Coronary artery disease (CAD) is a leading cause of morbidity and mortality in the developed world and is rapidly assuming epidemic proportions in developing countries, including India. This has led to extensive research to determine the risk factors and the pathways that may predispose to the elevated risk of this disease. Important among them include lipoproteins, homocysteine, lipoprotein (a), pro-inflammatory cytokines and others. The following study was undertaken to determine a possible inter-relationship between inflammation and dyslipidaemia, which are important risk factors for CAD in the atherosclerosis-prone North Indian male population.


METHODS
The study groups comprised 150 clinically assessed North Indian male patients with acute myocardial infarction (AMI), diagnosed on electrocardiographic and biochemical criteria, and 150 healthy controls. Apolipoprotein-AI (Apo-AI), apolipoprotein-B (Apo-B) and C-reactive protein (CRP) levels were estimated using kits based on the immunoturbidimetric assay from Randox, UK. Tumour necrosis factor-alpha (TNF-alpha) and lipoprotein (a) were assayed using commercially available ELISA kits from Diaclone Research, Belgium and Innogenetics, Belgium, respectively.


RESULTS
The patients with AMI showed highly significant elevations in the levels of total serum cholesterol, triglycerides, LDL cholesterol, Apo-B and a significant decline in HDL cholesterol, compared with healthy controls. Significantly elevated serum levels of inflammatory markers, TNF-alpha and CRP were seen in patients with AMI, compared to the control subjects. A significantly positive correlation of TNF-alpha was observed with lipoprotein (a) in patients with CAD.


CONCLUSIONS
The data clearly underlines a possible interplay between inflammation and dyslipidaemia in the pathogenesis of CAD in the Indian context. This insight into the aetiopathogenesis of CAD will prove highly beneficial for devising better preventive measures and pharmacological interventions for CAD.
Department of Biochemistry, GB Pant Hospital, New Delhi, India. binitadr@yahoo.co.in
B
B
Goswami
M
M
Rajappa
B
B
Singh
P C
PC
Ray
S
S
Kumar
V
V
Mallika
D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015592:Immunoradiometric Assay; D007194:India / Q000453:epidemiology; D007249:Inflammation / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D002097:C-Reactive Protein