Myocardial infarction in nondiabetic and prediabetic population: a retrospective analysis.
Diabetes mellitus (DM) is one of the important risk factors for cardiac diseases. Type 2 DM is the commonest form of diabetes, which is characterized by insulin resistance. Insulin resistance can be preceded by long term abnormality in glucose homeostasis which is called pre-diabetes. Recently, pre-diabetes has been suggested to have an increased risk of cardiovascular disease. Considering that India has been declared as a diabetic capital of the world it deemed pertinent to assess the exact load of pre diabetics and non diabetics landing in myocardial infarction. We analyzed retrospectively the data of all patients admitted for the first time for acute myocardial infarction (MI) and evaluated the load of non diabetics, pre diabetics and diabetics among them. We found difference in the severity of diseases and degree of biochemical alterations among the three groups suggesting that abnormal glucose homeostasis has no role on the severity of MI. No previous studies have investigated the difference in male and female MI patients with respect to their glucose metabolism and its impact on the severity of the disease. Our study reveals that males even with normal glucose level are at increased risk to develop MI. Males on the other hand have increased risk for MI when compared to females with normal glucose homeostasis.
Department of Biochemistry, Pondicherry Institute of Medical Sciences (PIMS), Pondicherry - 605 014.
Nivedita
N
Nanda
Sanat Kumar
SK
Sen
Mark C
MC
Arokiaraj
R
R
Sripradha
R
R
Roma
Kiran
K
Pattegar
D000328:Adult; D000368:Aged; D015415:Biomarkers; D001772:Blood Cell Count; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007194:India / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000453:epidemiology*; D011236:Prediabetic State / Q000150:complications / Q000201:enzymology / Q000453:epidemiology*; D012189:Retrospective Studies; D012737:Sex Factors
D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids