[Homocysteine and von Willebrand factor in chronic alcoholism].
The levels of homocysteine (HC) and von Willebrand factor (VWF) as cardiovascular risk factors were studied in patients with Stage II chronic alcoholism. Forty-one men with Stage II chronic alcoholism without clinical signs of somatic and infectious diseases were examined. Their median age was 37 (range 32-40) years; the alcoholization period was 12 (range 8-17) years. Plasma HC and VWF (amount and activity) levels were determined. In 63.4% of chronic alcoholic patients, HC levels was twice as high as in the controls; in 80.6%, both the content and activity of VWF were increased. There was no correlation between the levels of HC and VWF. Vascular endothelial damage concurrent with hyperhomocysteinemia increases a cardiovascular risk in patients with Stage II chronic alcoholism.
A M
AM
Koriakin
N N
NN
Epifantseva
I V
IV
Dadyka
Ia A
IaA
Gorbatovskiĭ
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000150:complications; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D012307:Risk Factors; D014841:von Willebrand Factor / Q000378:metabolism*
D014841:von Willebrand Factor; D006710:Homocysteine