title: [Endolaryngeal surgery and photodynamical therapy of using flexible videoendoscopic devices to treat laryngeal cancer and premalignancy].
abstract: Patients with laryngeal cancer (LC) and premalignancy admitted to P.A. Gertsen Moscow Research Oncological Institute were treated by the methods of endolaryngeal surgery making use of flexible videoendoscopic devices, Nd:YAG laser-assisted thermal ablation, argon plasma coagulation, electroresection, and photodynamical therapy. A total of 129 patients were given treatment by these techniques following distant radiotherapy including 23 with grade I-III laryngeal dyskeratosis and dysplasia, 36 with virus-associated recurrent laryngeal papillomatosis, 37 with early cancer (Tis-T1NoMo) in the middle part of the larynx, 17 with a residual tumour, and 16 with mid-laryngeal cancer (T1-2NoMo). The above treatments resulted in complete regression (CR) of dyskeratosis and grade I-III dysplasia in 22 (95%) of the 23 patients and CR of recurrent papilllomatosis in 27 (75%) of the 36 patients. Moreover, complete regression was achieved in 34 (92%) of the 37 patients with laryngeal cancer. It recurred in 3 (9%) of the 34 patients. In all cases, the vocal function was completely restored. In groups with residual and recurring laryngeal tumours, complete remission was documented in 27 (82%) of the 33 patients. LC recurred in three patients within 1-5 years after completion of the treatment.
authors.forename: V V
authors.initials: VV
authors.lastname: Sokolov
authors.forename: L V
authors.initials: LV
authors.lastname: Telegina
authors.forename: A A
authors.initials: AA
authors.lastname: Gladyshev
authors.forename: I V
authors.initials: IV
authors.lastname: Reshetov
authors.forename: V O
authors.initials: VO
authors.lastname: Ol'shanskiĭ
authors.forename: A K
authors.initials: AK
authors.lastname: Golubtsov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D007828:Laryngoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D011230:Precancerous Conditions / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D020535:Video-Assisted Surgery / Q000295:instrumentation*