title: Peripheral biomarkers and illness activity in bipolar disorder.
abstract: Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of previously described biomarkers in different mood states (n = 60) as well as in healthy subjects (n = 80). To make the point that these are ominous changes, we obtained the same measures from a group of septic patients (n = 15) as a "positive" control group. In this sample, we measured serum levels of brain derived neurotrophic factor, neurotrophin 3, tumor necrosis factor α, interleukin 6, interleukin 10, total reactive antioxidant potential, thiobarbituric acid reactive substances and protein carbonyl content. Several of the markers discriminated between the bipolar and control groups, especially when patients were in acute episodes. In some cases, toxicity was as high in bipolar disorder as that seen in patients with sepsis. We believe these findings highlight the potential of using biomarkers to assess illness activity in bipolar disorder.
authors.affiliation: Bipolar Disorders Program & INCT for Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. kapcz@terra.com.br
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Pedro V S
authors.initials: PV
authors.lastname: Magalhaes
authors.forename: Márcia
authors.initials: M
authors.lastname: Kauer-Sant'Anna
authors.forename: Fábio
authors.initials: F
authors.lastname: Klamt
authors.forename: José Claudio F
authors.initials: JC
authors.lastname: Moreira
authors.forename: Mateus Augusto
authors.initials: MA
authors.lastname: de Bittencourt Pasquali
authors.forename: Gabriel Rodrigo
authors.initials: GR
authors.lastname: Fries
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: Clarissa Severino
authors.initials: CS
authors.lastname: Gama
authors.forename: Robert
authors.initials: R
authors.lastname: Post
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001714:Bipolar Disorder / Q000378:metabolism* / Q000503:physiopathology*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D055809:Illness Behavior; D008297:Male; D008875:Middle Aged; D020933:Neurotrophin 3 / Q000097:blood; D050050:Protein Carbonylation; D013223:Statistics as Topic; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D020933:Neurotrophin 3; D017392:Thiobarbituric Acid Reactive Substances