title: Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery.
abstract: OBJECTIVE
  To further evaluate the relationship between thyroid antibodies and preterm births.
  
  
  METHODS
  This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First- and Second-Trimester Risk of Aneuploidy [FaSTER] trial).
  
  
  RESULTS
  Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements.
  
  
  CONCLUSIONS
  The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.
  
  
  METHODS
  II.
authors.affiliation: From the Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island; the Savjani Institute for Health Research, Standish, Maine; Columbia University College of Physicians and Surgeons, New York, New York; the Royal College of Surgeons in Ireland, Dublin, Ireland; the University of Utah and Intermountain HealthCare, Salt Lake City, Utah; the Swedish Medical Center, Seattle, Washington; and Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
authors.forename: James E
authors.initials: JE
authors.lastname: Haddow
authors.forename: Jane
authors.initials: J
authors.lastname: Cleary-Goldman
authors.forename: Monica R
authors.initials: MR
authors.lastname: McClain
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Palomaki
authors.forename: Louis M
authors.initials: LM
authors.lastname: Neveux
authors.forename: Geralyn
authors.initials: G
authors.lastname: Lambert-Messerlian
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Canick
authors.forename: Fergal D
authors.initials: FD
authors.lastname: Malone
authors.forename: T Flint
authors.initials: TF
authors.lastname: Porter
authors.forename: David A
authors.initials: DA
authors.lastname: Nyberg
authors.forename: Peter S
authors.initials: PS
authors.lastname: Bernstein
authors.forename: Mary E
authors.initials: ME
authors.lastname: D'Alton
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000276:immunology; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D047928:Premature Birth / Q000209:etiology*; D011446:Prospective Studies; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D007453:Iodide Peroxidase