A Hydroxyurea-induced Leg Ulcer.
Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration, and xerosis. The leg ulcers were refractory to conventional treatment. She had been taking oral hydroxyurea since being diagnosed with essential thrombocytosis in 2002. Hence, we suspected hydroxyurea-induced leg ulcers and discontinued her hydroxyurea treatment; the ulcers gradually healed thereafter. We present a rare case of hydroxyurea-induced leg ulcers in Korea.
Hwang
Seon-Wook
SW
Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
Hong
Soon-Kwon
SK
Kim
Sang-Hyun
SH
Seo
Jong-Keun
JK
Lee
Deborah
D
Sung
Ho-Suk
HS