title: Neural dynamics of in vitro cortical networks reflects experienced temporal patterns.
abstract: Learning ultimately relies on changes in the flow of activity in neural microcircuits. The plasticity of neural dynamics is particularly relevant for the processing of temporal information. Chronic stimulation of cultured rat cortical networks revealed experience-dependent plasticity in neural dynamics. We observed changes in the temporal structure of activity that reflected the intervals used during training, suggesting that cortical circuits are inherently capable of temporal processing on short timescales.
authors.affiliation: Champalimaud Neuroscience Programme, Instituto Gulbenkian de Ciencia, Oeiras, Portugal.
authors.forename: Hope A
authors.initials: HA
authors.lastname: Johnson
authors.forename: Anubhuthi
authors.initials: A
authors.lastname: Goel
authors.forename: Dean V
authors.initials: DV
authors.lastname: Buonomano
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D007858:Learning / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D051381:Rats; D013997:Time Factors