Biomonitoring equivalents for hexachlorobenzene.
Recent efforts worldwide have resulted in a growing database of measured concentrations of chemicals in blood and urine samples taken from the general population. However, few tools exist to assist in the interpretation of the measured values in a health risk context. Biomonitoring equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guideline. This study reviews available health-based exposure guidance values for hexachlorobenzene (HCB) from Health Canada, the United States Environmental Protection Agency (US EPA), the US Agency for Toxic Substances and Disease Registry (ATSDR) and World Health Organization (WHO). HCB liver tissue concentrations in chronic rodent bioassays and information on human elimination rates and tissue distribution of HCB were extrapolated to estimate serum lipid-adjusted HCB concentrations that are consistent with the exposure guidance values for HCB. Estimated serum lipid-adjusted HCB concentrations ranging from 16 to 250 ng/g lipid were consistent with non-cancer-based exposure guidance values from various agencies. Concentrations associated with cancer risk-specific doses at target risk levels of interest were also estimated. These BE values may be used as screening tools for evaluation of population biomonitoring data for HCB in a risk assessment context and can assist in prioritization of the potential need for additional risk assessment efforts for HCB relative to other chemicals.
Aylward
Lesa L
LL
Summit Toxicology, LLP, Falls Church, VA 22044, USA.
Hays
Sean M
SM
Gagné
Michelle
M
Nong
Andy
A
Krishnan
Kannan
K
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004781:Environmental Exposure / Q000592:standards / Q000706:statistics & numerical data; D004784:Environmental Monitoring / Q000592:standards*; D004785:Environmental Pollutants / Q000378:metabolism / Q000493:pharmacokinetics / Q000592:standards*; D004787:Environmental Pollution / Q000706:statistics & numerical data; D005260:Female; D005659:Fungicides, Industrial / Q000378:metabolism / Q000493:pharmacokinetics / Q000592:standards*; D006581:Hexachlorobenzene / Q000378:metabolism / Q000493:pharmacokinetics / Q000592:standards*; D006801:Humans; D008297:Male; D051381:Rats; D012016:Reference Values; D018570:Risk Assessment
D015415:Biomarkers; D004785:Environmental Pollutants; D005659:Fungicides, Industrial; D006581:Hexachlorobenzene