Molecular interactions in surface-assembled monolayers of short double-stranded DNA.
We present an experimental study of the energetics of repulsion between end-grafted fragments of double-stranded DNA. The absorption isotherm of thiolated DNA fragments has been measured as a function of DNA chain length as well as the salinity of the surrounding solution. The results are consistent with a simple excluded-volume model of the interaction between neighboring DNA strands.
Huang
Ling
L
Center for Microsystems for the Life Sciences, University of California, Santa Barbara, California 93117, USA.
Seker
Erkin
E
Landers
James P
JP
Begley
Matthew R
MR
Utz
Marcel
M
D000042:Absorption; D004247:DNA / Q000737:chemistry*; D008962:Models, Theoretical
D004247:DNA