Modeling the stability of cephamycin C-producing N. Lactamdurans during continuous culture.
The reversion of a cephamycin C-producing strain of Nocardia lactamdurans to a non-producing variant under continuous culture conditions was examined at dilution rates between 0.025 and 0.045 hr(-1). A model incorporating the influence of revertants, when present in the culture in significant numbers, was necessary to adequately describe the dynamics of the reversion process.
Kirpekar
A C
AC
Department of Chemical Engineering University of Virginia Charlottesville, VA 22901.
Kirwan
D J
DJ
Stieber
R W
RW