Development of the C. elegans digestive tract.
The C. elegans digestive tract (pharynx, intestine, and rectum) contains only approximately 100 cells but develops under the control of the same types of transcription factors (e.g. FoxA and GATA factors) that control digestive tract development in far more complex animals. The GATA-factor dominated core regulatory hierarchy directing development of the homogenous clonal intestine from oocyte to mature organ is now known with some degree of certainty, setting the stage for more biochemical experiments to understand developmental mechanisms. The FoxA-factor dominated development of the pharynx (and rectum) is less well understood but is beginning to reveal how transcription factor combinations produce unique cell types within organs.
Kormish
Jay D
JD
Department of Molecular Biology and Biochemistry, Department of Medical Genetics, Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada.
Gaudet
Jeb
J
McGhee
James D
JD
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage; D047108:Embryonic Development / Q000235:genetics; D050980:GATA Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D041981:Gastrointestinal Tract / Q000166:cytology / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D007422:Intestines / Q000166:cytology / Q000196:embryology; D010614:Pharynx / Q000166:cytology / Q000196:embryology; D012007:Rectum / Q000166:cytology / Q000196:embryology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D050980:GATA Transcription Factors; C113277:Pha-4 protein, C elegans; D015534:Trans-Activators