Relationship of soluble fas with body mass index in healthy Japanese adults.
Recent studies have linked elevated serum sFas levels to atherosclerotic disease among patients. Confirming an association between obesity and serum sFas levels in healthy subjects would facilitate our understanding of obesity and its related disorders. We therefore analyzed serum sFas levels of 8,541 subjects selected as controls for a nested case-control study within the JACC Study. Body mass index (BMI) was calculated as the indicator of obesity based on self-reported height and weight. We found a statistically significant positive association between serum sFas levels and BMI among our apparently healthy subjects. Our result suggests that serum sFas rises to down-regulate increased apoptosis in atherogenesis processes caused by obesity.
Tamakoshi
Akiko
A
Department of Public Health, Aichi Medical University School of Medicine, Japan. tamaa@aichi-med-u.ac.jp
Suzuki
Koji
K
Lin
Yingsong
Y
Ito
Yoshinori
Y
Yagyu
Kiyoko
K
Kikuchi
Shogo
S
Watanabe
Yoshiyuki
Y
Inaba
Yutaka
Y
Tajima
Kazuo
K
Nakachi
Kei
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D019014:fas Receptor / Q000097:blood*
D015415:Biomarkers; C491901:FAS protein, human; D019014:fas Receptor