Engineered heart tissue: high throughput platform for dissection of complex diseases.
The polygenic nature of resistance/sensitivity of the heart to ischemia is generally accepted. Unfortunately, little is known about gene(s) involved in response to this insult. The goal of present study is to introduce new tool, engineered heart tissue (EHT), for accelerating positional cloning and for providing novel functional assays.
Lazar
Jozef
J
Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jlazar@mcw.edu
Jacob
Howard J
HJ
Wakatsuki
Tetsuro
T
D000818:Animals; D020296:Animals, Congenic; D003001:Cloning, Molecular / Q000379:methods; D005260:Female; D023281:Genomics; D057166:High-Throughput Screening Assays / Q000379:methods*; D008297:Male; D017202:Myocardial Ischemia / Q000235:genetics / Q000517:prevention & control*; D009206:Myocardium; D010641:Phenotype; D051381:Rats; D023822:Tissue Engineering; D014161:Transduction, Genetic