title: Citric-acid-derived photo-cross-linked biodegradable elastomers.
abstract: Citric-acid-derived thermally cross-linked biodegradable elastomers (CABEs) have recently received significant attention in various biomedical applications, including tissue-engineering orthopedic devices, bioimaging and implant coatings. However, citric-acid-derived photo-cross-linked biodegradable elastomers are rarely reported. Herein, we report a novel photo-cross-linked biodegradable elastomer, referred to as poly(octamethylene maleate citrate) (POMC), which preserves pendant hydroxyl and carboxylic functionalities after cross-linking for the potential conjugation of biologically active molecules. Pre-POMC is a low-molecular-mass pre-polymer with an average molecular mass between 701 and 1291 Da. POMC networks are soft and elastic with an initial modulus of 0.07 to 1.3 MPa and an elongation-at-break between 38 and 382%. FT-IR-ATR results confirmed the successful surface immobilization of type-I collagen onto POMC films, which enhanced in vitro cellular attachment and proliferation. Photo-polymerized POMC films implanted subcutaneously into Sprague-Dawley rats demonstrated minimal in vivo inflammatory responses. The development of POMC enriches the family of citric-acid-derived biodegradable elastomers and expands the available biodegradable polymers for versatile needs in biomedical applications.
authors.affiliation: Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA.
authors.forename: Dipendra
authors.initials: D
authors.lastname: Gyawali
authors.forename: Richard T
authors.initials: RT
authors.lastname: Tran
authors.forename: Kristine J
authors.initials: KJ
authors.lastname: Guleserian
authors.forename: Liping
authors.initials: L
authors.lastname: Tang
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D001458:Bandages; D002448:Cell Adhesion / Q000187:drug effects; D019343:Citric Acid / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D020724:Elastomers / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D005549:Foreign-Body Reaction / Q000139:chemically induced; D006801:Humans; D055767:Immobilized Proteins / Q000737:chemistry; D008298:Maleates / Q000737:chemistry; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D008970:Molecular Weight; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects; D041681:NIH 3T3 Cells; D055668:Photochemical Processes; D051381:Rats; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013696:Temperature; D023822:Tissue Engineering
chemical_list: D020724:Elastomers; D055767:Immobilized Proteins; D008298:Maleates; D013438:Sulfhydryl Compounds; C557053:poly(octamethylene maleate citrate); D019343:Citric Acid; D003094:Collagen; C030272:maleic acid; C516316:1,8-octanedithiol