Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway.
Ansellone A (1) has been isolated from the dorid nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It has the new "ansellane" sesterterpenoid carbon skeleton, and it activates the cAMP signaling pathway.
Daoust
Julie
J
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
Fontana
Angelo
A
Merchant
Catherine E
CE
de Voogd
Nicole J
NJ
Patrick
Brian O
BO
Kieffer
Timothy J
TJ
Andersen
Raymond J
RJ
D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D049851:Gastropoda / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
D054830:Sesterterpenes; C552584:ansellone A; D000242:Cyclic AMP