Relationship between uric acid and metabolic syndrome according to menopausal status.
OBJECTIVE
Uric acid, the levels of which have been shown to increase after menopause, has been associated with metabolic syndrome. The prevalence of metabolic syndrome has also been determined to increase after menopause. Therefore, we surmised that menopausal status-specific analyses for the characterisation of the relationship between uric acid and the metabolic syndrome were warranted.


METHODS
We included 1644 patients: 1018 premenopausal women and 626 postmenopausal women, all of whom participated in annual health examinations at Anam Hospital in Seoul, Korea, from January 2008 through December 2008.


RESULTS
On the multivariate logistic regression analysis, uric acid was identified as an independent risk factor for metabolic syndrome in both premenopausal and postmenopausal women. Uric acid levels had different relationships with blood pressure based on menopausal status, however, no such relationships with fasting glucose or age were found.


CONCLUSIONS
Increased uric acid levels were associated with increased risk for metabolic syndrome in both premenopausal and postmenopausal women. In studies regarding uric acid and metabolic syndrome in women, the effects of menopausal status should be considered.
Lee
Hee Jung
HJ
Department of Obstetrics and Gynecology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
Park
Hyun Tae
HT
Cho
Geum Joon
GJ
Yi
Kyung Wook
KW
Ahn
Ki Hoon
KH
Shin
Jung-Ho
JH
Kim
Tak
T
Kim
Young Tae
YT
Hur
Jun Young
JY
Kim
Sun Haeng
SH
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D008593:Menopause / Q000097:blood* / Q000502:physiology; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D008055:Lipids; D014527:Uric Acid