title: Area dependent expression of ZNF312 in human fetal cerebral cortex.
abstract: The human cerebral neocortex is divided into six layers consisting of specific neuronal cell types and connections. To determine the distribution of cortical neurons during early development, we examined the expressions of layer-specific markers in human midterm fetal brains. Layer V marker ZNF312 is expressed in most cortical areas, but not in the prospective somatosensory association area. Expression of layer IV marker RORbeta is also diminished in this region but increased in the primary visual cortex, where expression of ZNF312 is reduced. Our results indicate that ZNF312 and other layer markers have area dependent expressions in the human fetal cortex.
authors.affiliation: Key Laboratory of Visual Science, National Ministry of Health, and School of Optometry and Ophthalmology, Wenzhou Medical College, PR China. zh@wzmc.net
authors.forename: Hua
authors.initials: H
authors.lastname: Zhu
authors.forename: Yaojuan
authors.initials: Y
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Huaping
authors.initials: H
authors.lastname: Tao
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Qu
authors.forename: Jia
authors.initials: J
authors.lastname: Qu
authors.forename: Jieguang
authors.initials: J
authors.lastname: Chen
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D005326:Fetal Proteins / Q000096:biosynthesis / Q000235:genetics*; D005333:Fetus; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D057095:Nuclear Receptor Subfamily 1, Group F, Member 2 / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D015415:Biomarkers; C557090:FEZF2 protein, human; D005326:Fetal Proteins; C475491:MAP1B protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D057095:Nuclear Receptor Subfamily 1, Group F, Member 2; C539740:RORB protein, human; D014157:Transcription Factors