title: Childhood and adolescent orofacial granulomatosis is strongly associated with Crohn's disease and responds to intralesional corticosteroids.
abstract: We present seven cases of orofacial granulomatosis occurring in paediatric patients aged 6-16 years. All patients were investigated for Crohn's disease and a strong association was found. All patients were treated with intralesional corticosteroid injections with excellent clinical responses. We review the literature and discuss the epidemiological association between childhood orofacial granulomatosis and Crohn's disease, as well as various treatment options, and propose a treatment protocol that was efficacious and well tolerated in all our patients.
authors.affiliation: The Royal Children's Hospital, Parkville, Victoria, Australia. alanatuxen@yahoo.com
authors.forename: Alana J
authors.initials: AJ
authors.lastname: Tuxen
authors.forename: David
authors.initials: D
authors.lastname: Orchard
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage; D002648:Child; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D051261:Granulomatosis, Orofacial / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional / Q000009:adverse effects; D008297:Male; D010146:Pain / Q000209:etiology; D059408:Pain Management; D016896:Treatment Outcome; D014732:Vibration / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000779:Anesthetics, Local