title: A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus.
abstract: A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl-1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data. Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 μg/ml, respectively.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Santi.Ti@chula.ac.th
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
authors.forename: Yawistha
authors.initials: Y
authors.lastname: Limpipatwattana
authors.forename: Suttira
authors.initials: S
authors.lastname: Khumkratok
authors.forename: Pongpan
authors.initials: P
authors.lastname: Siripong
authors.forename: Jirapast
authors.initials: J
authors.lastname: Sichaem
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005260:Female; D054335:Goniothalamus / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D009062:Mouth Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C557383:laoticuzanone A