title: Mussel-inspired transformation of CaCO3 to bone minerals.
abstract: We report a mussel-inspired route to create carbonated bone hydroxyapatite from CaCO(3) vaterite microspheres. When catechol-containing dopamine, a biomimetic small molecule of mussel adhesive proteins, was incorporated during the mineralization of CaCO(3), the oxidative polymerization of dopamine stabilized the formation of spherical vaterite, the most unstable phase among CaCO(3) crystalline structures. Thus-formed vaterite microspheres were readily transformed to carbonated hydroxyapatite crystals when incubated in a simulated body fluid at human body temperature. We found that dopamine not only stabilized the vaterite phase but also influenced the level of conversion to carbonated hydroxyapatites. Considering that carbonated hydroxyapatites are highly bioresorbable, similar to natural bone and dentin, the synthesis of a mussel-inspired hybrid material showing good in vitro bone bioactivity should present a new prospect for future applications in the treatment of bone defects and bone degenerative diseases.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701, Republic of Korea.
authors.forename: Sungjin
authors.initials: S
authors.lastname: Kim
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D000818:Animals; D032701:Biomimetics / Q000379:methods*; D049872:Bivalvia / Q000378:metabolism; D001842:Bone and Bones / Q000737:chemistry; D002119:Calcium Carbonate / Q000737:chemistry*; D003460:Crystallization; D004298:Dopamine / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D008903:Minerals / Q000737:chemistry*
chemical_list: D008903:Minerals; D017886:Durapatite; D002119:Calcium Carbonate; D004298:Dopamine