title: Late auditory event-related evoked potential (P300) in Down's syndrome patients.
abstract: Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease.
  
  
  OBJECTIVE
  To evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome.
  
  
  METHODS
  Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. RESULTS The P300 latency (N1, P2, N2 and P3) was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group.
  
  
  CONCLUSIONS
  In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced, suggesting integration impairment between the auditory association area and cortical and subcortical areas of the central nervous system.
authors.affiliation: Sao Paulo Federal University, Paulista Medical School.
authors.forename: Carla Patrícia Hernandez Alves Ribeiro
authors.initials: CP
authors.lastname: César
authors.forename: Heloisa Helena
authors.initials: HH
authors.lastname: Caovilla
authors.forename: Mário Sérgio Lei
authors.initials: MS
authors.lastname: Munhoz
authors.forename: Maurício Malavasi
authors.initials: MM
authors.lastname: Ganança
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004314:Down Syndrome / Q000503:physiopathology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011930:Reaction Time; D055815:Young Adult