Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis.
Inhibition of fatty acid synthase (FAS) has been proposed to be a new therapeutic target for the treatment of cancer and obesity. In our preliminary screening study on the FAS inhibitory activity, a n-hexane soluble fraction prepared from the fruit of Schisandra chinensis (Schisandraceae) was found to inhibit FAS activity at 100 microg/mL. Nine dibenzocyclooctadiene lignans were isolated from the active fraction and were evaluated for their inhibitory effect on FAS for the first time. The compounds possessing a benzoyl or tigloyl group in the dibenzocyclooctadiene skeleton entirely inhibited the FAS activity in a dose dependent manner. The findings may be partially related to the anticancer effect of the medicinal plant, suggesting a further study on the anticancer potential of dibenzocyclooctadiene derivatives.
Na
MinKyun
M
College of Pharmacy, Yeungnam University, Gyeongbuk, South Korea. mkna@ynu.ac.kr
Hung
Tran Manh
TM
Oh
Won Keun
WK
Min
Byung Sun
BS
Lee
Seung Ho
SH
Bae
KiHwan
K
D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors*; D005638:Fruit / Q000737:chemistry; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry*
D034242:Cyclooctanes; D017705:Lignans; D010936:Plant Extracts; C510994:dibenzocyclooctadiene lignan; D064429:Fatty Acid Synthases