Metastasis of renal cell carcinoma to a haemangioblastoma of the medulla oblongata in von Hippel-Lindau syndrome.
We describe a patient with von Hippel-Lindau (VHL) syndrome with metastasis of renal cell carcinoma (RCC) to a haemangioblastoma (HAB) of the medulla oblongata. Histological examination revealed cells with clear cytoplasm arranged in alveolar or tubular patterns in most fields of view. In a small area, the tumor showed abundant thin-walled vessels and clear cells. Immunohistochemically, staining for cytokeratin, epithelial membrane antigen and CD10 was typically positive in the tumor portion that contained RCC but not in the HAB. The HAB was immunopositive for inhibin-alpha and CD34. Detailed histological analysis and immunohistochemistry should allow differentiation of HAB and RCC.
Xiong
Ji
J
Department of Neuropathology, Institute of Neurology and Huashan Hospital of Fudan University, 12 Wu Lu Mu Qi Zhong Road, Shanghai 200040, China.
Chu
Shu-Guang
SG
Wang
Yin
Y
Zhu
Jing-Jing
JJ
Li
Chao
C
Mao
Ying
Y
D000328:Adult; D020295:Brain Stem Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D018325:Hemangioblastoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology