The nuclear pore complex: bridging nuclear transport and gene regulation.
Although the nuclear pore complex (NPC) is best known for its primary function as the key regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of experimental evidence suggests that this structure participates in a considerably broader range of cellular activities on both sides of the nuclear envelope. Indeed, the NPC is emerging as an important regulator of gene expression through its influence on the internal architectural organization of the nucleus and its apparently extensive involvement in coordinating the seamless delivery of genetic information to the cytoplasmic protein synthesis machinery.
Strambio-De-Castillia
Caterina
C
Department of Microbiology and Molecular Medicine, University of Geneva, 1 Rue Michel Servet, CH-1211 Geneva, Switzerland. caterina.strambio@unige.ch
Niepel
Mario
M
Rout
Michael P
MP
D021581:Active Transport, Cell Nucleus / Q000235:genetics / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D022022:Nuclear Pore / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000235:genetics / Q000502:physiology