title: Combining gastric and ileal segments, does it overcome segment-related complications? An experimental study on rats.
abstract: Bladder augmentation has revolutionized the care of children with neurogenic bladder but it is associated with certain short- and long-term complications. Using the combination of gastric and ileal segments to balance effects of these segments might be a solution for complications. A total of 39 female Spraque-Dawley rats randomly divided into four groups: ileocystoplasty (11), gastrocystoplasty (9), ileogastrocystoplasty (11) and control (8). Serum/urine electrolytes and pH values, and serum creatinine levels and urine mucus concentration were measured. Kruskal-Wallis non-parametric variance analysis was performed to compare the groups and p < 0.05 was accepted as significant. Metabolic alkalosis with significantly lower urine pH was observed in gastrocystoplasty group. Gastroileal group showed similar results with the ileal group in all parameters. No stone formation was detected in the sham and gastric cystoplasty groups. Metaplastic and hyperplastic changes were observed in all segments surrounding urothelium. In conclusion, combination of gastric and ileal segments does not significantly reduce the rate of metabolic impairments, stone and mucus formation. Besides it is not associated with significant improvement in histological outcome since urine is still in contact with the gastrointestinal mucosa.
authors.affiliation: Department of Urology, Ankara University School of Medicine, Adnan Saygun cad, Ankara, Turkey.
authors.forename: Berk
authors.initials: B
authors.lastname: Burgu
authors.forename: Mehmet İlker
authors.initials: Mİ
authors.lastname: Gökce
authors.forename: Özgü
authors.initials: Ö
authors.lastname: Aydoğdu
authors.forename: Evren
authors.initials: E
authors.lastname: Süer
authors.forename: Duygu
authors.initials: D
authors.lastname: Kankaya
authors.forename: Tarkan
authors.initials: T
authors.lastname: Soygür
mesh_terms: D000818:Animals; D004573:Electrolytes / Q000097:blood; D005260:Female; D006965:Hyperplasia / Q000473:pathology; D007082:Ileum / Q000473:pathology / Q000637:transplantation*; D007422:Intestines / Q000473:pathology; D008679:Metaplasia / Q000473:pathology; D009092:Mucous Membrane / Q000473:pathology; D011183:Postoperative Complications / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000473:pathology / Q000637:transplantation*; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery*
chemical_list: D004573:Electrolytes