Caught in the act: in vivo development of macrolide resistance to Campylobacter jejuni infection.
We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistance in C. jejuni.
Lindow
J C
JC
Vaccine Testing Center, University of Vermont College of Medicine, Department of Medicine, Burlington, VT 05405, USA. janet.lindow@uvm.edu
Poly
F
F
Tribble
D R
DR
Guerry
P
P
Carmolli
M P
MP
Baqar
S
S
Porter
C K
CK
Pierce
K K
KK
Darsley
M J
MJ
Sadigh
K S
KS
Dill
E A
EA
Kirkpatrick
B D
BD
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D015373:Bacterial Typing Techniques; D002169:Campylobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D064368:Healthy Volunteers; D006801:Humans; D018942:Macrolides / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D055815:Young Adult
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D018942:Macrolides