title: Q fever as a cause of fever of unknown origin and thrombocytosis: first molecular evidence of Coxiella burnetii in Brazil.
abstract: We report a case of Q fever in a man who presented with fever of 40 days duration associated with thrombocytosis. Serological and molecular analysis (polymerase chain reaction) confirmed infection with Coxiella burnetii. A field study was conducted by collecting blood samples from the patient's family and from the animals in the patient's house. The patient's wife and 2 of 13 dogs showed seroreactivity. Our data indicate that C. burnetii may be an underrecognized cause of fever in Brazil and emphasize the need for clinicians to consider Q fever in patients with a febrile illness, particularly those with a history of animal contact.
authors.affiliation: Laboratory of Hantaviroses and Rickettsioses, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil. elemos@ioc.fiocruz.br
authors.forename: Elba R S
authors.initials: ER
authors.lastname: Lemos
authors.forename: Tatiana
authors.initials: T
authors.lastname: Rozental
authors.forename: Maria Angélica M
authors.initials: MA
authors.lastname: Mares-Guia
authors.forename: Daniele N P
authors.initials: DN
authors.lastname: Almeida
authors.forename: Namir
authors.initials: N
authors.lastname: Moreira
authors.forename: Raphael G
authors.initials: RG
authors.lastname: Silva
authors.forename: Jairo D
authors.initials: JD
authors.lastname: Barreira
authors.forename: Cristiane C
authors.initials: CC
authors.lastname: Lamas
authors.forename: Alexsandra R
authors.initials: AR
authors.lastname: Favacho
authors.forename: Paulo V
authors.initials: PV
authors.lastname: Damasco
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001938:Brazil; D016997:Coxiella burnetii / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004285:Dogs; D005260:Female; D005335:Fever of Unknown Origin / Q000382:microbiology*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011778:Q Fever / Q000097:blood / Q000175:diagnosis*; D013922:Thrombocytosis / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004269:DNA, Bacterial