title: Inhibition of twisting of a green fluorescent protein-like chromophore by metal complexation.
abstract: Substitution of a pyridyl for the hydroxyphenyl moiety in the Green Fluorescent Protein analog p-hydroxybenzylidene-dimethylimidiazolinone produces a chromophore which "turns on" fluorescence in the presence of Zn(2+) or Cd(2+) ions. Such a phenomenon provides "proof of principle" for using GFP chromophores in a variety of sensing applications.
authors.affiliation: School of Chemistry and Biochemistry, 901 Atlantic Dr, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Baldridge
authors.forename: Kyril M
authors.initials: KM
authors.lastname: Solntsev
authors.forename: Charles
authors.initials: C
authors.lastname: Song
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tanioka
authors.forename: Janusz
authors.initials: J
authors.lastname: Kowalik
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hardcastle
authors.forename: Laren M
authors.initials: LM
authors.lastname: Tolbert
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D002104:Cadmium / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D049452:Green Fluorescent Proteins / Q000737:chemistry; D048288:Imidazolines / Q000737:chemistry*; D008024:Ligands; D008968:Molecular Conformation; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000737:chemistry
chemical_list: D001593:Benzyl Compounds; D056831:Coordination Complexes; D048288:Imidazolines; D008024:Ligands; C533767:p-hydroxybenzylidenedimethylimidazolinone; D002104:Cadmium; D049452:Green Fluorescent Proteins; D015032:Zinc