Can we use neopterin as marker of viral infections in pregnant women with symptoms of imminent spontaneous abortion?
OBJECTIVE
To find out if determination of neopterin can be used for the detection of viral infections in pregnant women with symptoms of imminent spontaneous abortion.


METHODS
Eighty-eight pregnant women with symptoms of imminent spontaneous abortion (investigated group) and 88 healthy pregnant women were evaluated (control group). Neopterin level and IgM and IgG antibodies for eight viruses in the blood were determined.


RESULTS
Parvo B19 virus and elevated neopterin values were found in significantly higher number in investigated group than in control. There was no correlation between women with acute ParvoB19 infection and elevated neopterin level.


CONCLUSIONS
The determination of neopterin in the sera cannot be used for screening of viral infections in pregnancy.
Bogavac
Mirjana A
MA
Department of Obstetrics and Gynecology, Clinical Centre Vojvodina, Alekse Santica 29, Novi Sad, Serbia. mbogavac@yahoo.com
Brkic
Snezana
S
Simin
Natasa
N
Nikolic
Aleksandra
A
Grujic
Zorica
Z
Milosevic
Vesna
V
Bozin
Biljana
B
D000022:Abortion, Spontaneous / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D019798:Neopterin / Q000032:analysis / Q000097:blood*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D011262:Pregnancy Trimester, Second / Q000097:blood; D014777:Virus Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult
D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D019798:Neopterin