Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust.
Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structure of 16 healthy individuals (age 21-44). The subjects were randomly exposed to diesel exhaust and filtered air on two separate occasions. Blood samples were collected before exposure, and 2 and 6 hours after exposure. There were no significant changes on clot permeability, maximum turbidity, lag time, fibre diameter, fibre density and fibrinogen level between samples taken after diesel exhaust exposure and samples taken after filtered air exposure. These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust.
Metassan
Sofian
S
Division of Cardiovascular and Diabetes Research, Section on Mechanisms of Thrombosis, Leeds Institute for Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Routledge
Michael N
MN
Lucking
Andrew J
AJ
Uitte de Willige
Shirley
S
Philippou
Helen
H
Mills
Nicholas L
NL
Newby
David E
DE
Ariëns
Robert As
RA
D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D005337:Fibrin / Q000187:drug effects*; D005340:Fibrinogen / Q000187:drug effects; D006801:Humans; D001335:Vehicle Emissions / Q000633:toxicity*; D055815:Young Adult
D000393:Air Pollutants; D001335:Vehicle Emissions; D005337:Fibrin; D005340:Fibrinogen