What lessons can be learned from studying the folding of homologous proteins?
The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at our disposal.
Nickson
Adrian A
AA
University of Cambridge, Department of Chemistry, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, UK.
Clarke
Jane
J
D000595:Amino Acid Sequence; D018398:Homeodomain Proteins / Q000737:chemistry; D007700:Kinetics; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D020598:Proto-Oncogene Proteins c-myb / Q000737:chemistry; D017385:Sequence Homology; D013816:Thermodynamics; D014157:Transcription Factors / Q000737:chemistry
D018398:Homeodomain Proteins; D011506:Proteins; D020598:Proto-Oncogene Proteins c-myb; D014157:Transcription Factors; C106185:engrailed homeobox proteins