Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats.
Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis.
Bashir
Samra
S
Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan.
Gilani
Anwar H
AH
Siddiqui
Anwar A
AA
Pervez
Shahid
S
Khan
Saeed R
SR
Sarfaraz
Noor Jehan
NJ
Shah
Abdul Jabbar
AJ
D000818:Animals; D028142:Berberis / Q000737:chemistry*; D004195:Disease Models, Animal; D006959:Hyperoxaluria / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D052878:Urolithiasis / Q000517:prevention & control*
D010936:Plant Extracts