title: Metastatic colorectal cancer with severe liver dysfunction successfully treated using FOLFOX therapy.
abstract: BACKGROUND
  The liver is the most frequent site of metastases from colorectal cancer (CRC), and extensive liver metastases often cause severe secondary liver dysfunction. However, whether chemotherapy for metastatic CRC with severe liver dysfunction offers any clinical benefit is unclear since patients in this setting are typically excluded from clinical trials.
  
  
  CONCLUSIONS
  We report herein a case of metastatic sigmoid colon cancer with severe liver dysfunction that was successfully treated using infusional 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX). FOLFOX was effective and well tolerated in the present case, and subsequent addition of bevacizumab to FOLFOX after disease progression was similarly feasible.
authors.forename: Takaya
authors.initials: T
authors.lastname: Shimura
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizushima
authors.forename: Kenji
authors.initials: K
authors.lastname: Murakami
authors.forename: Motoshi
authors.initials: M
authors.lastname: Mabuchi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Eiji
authors.initials: E
authors.lastname: Kubota
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D017093:Liver Failure / Q000188:drug therapy* / Q000209:etiology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil