title: Bilateral thalamic necrosis following ingestion of ridge gourd infested with coelomycete fungi (Diplodia).
abstract: Bilateral thalamic lesions detected on magnetic resonance imaging have a wide differential diagnosis. This report describes a previously healthy young man who developed bilateral thalamic necrosis with seizures, vomiting, hepatitis, neutrophilic leukocytosis and metabolic acidosis following consumption of raw dried fruits of the ridge gourd plant (Luffa acutangula) prescribed by a traditional medicine practitioner. These fruits were subsequently shown to be infested with spores and conidiomata of Diplodia, a coelomycete fungus known to cause neurotoxicity in farm animals. The patient made a partial recovery with supportive care, and has persistent deficits consistent with bilateral medial thalamic damage. This is the first report of neurological toxicity attributable to Diplodia in humans, and this entity should be considered in the differential diagnosis of bilateral thalamic lesions in the appropriate clinical setting.
authors.affiliation: Department of Neurology, Goa Medical College, Goa 403 202, India. adesouza1@gmail.com
authors.forename: Aaron
authors.initials: A
authors.lastname: de Souza
authors.forename: Kedareshwar P S
authors.initials: KP
authors.lastname: Narvencar
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Fernandes
authors.forename: G
authors.initials: G
authors.lastname: Arun
mesh_terms: D000328:Adult; D020314:Central Nervous System Fungal Infections / Q000150:complications*; D055135:Coelomomyces / Q000472:pathogenicity*; D005517:Foodborne Diseases / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009336:Necrosis / Q000209:etiology / Q000382:microbiology; D013786:Thalamic Diseases / Q000209:etiology / Q000382:microbiology / Q000473:pathology