Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
We conducted a genome-wide association study for testicular germ cell tumor, genotyping 298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating associations in a further 664 cases and 3,456 controls. We identified three new susceptibility loci, two of which include genes that are involved in telomere regulation. We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1.54, P=1.14x10(-23); rs2736100, OR=1.33, P=7.55x10(-15)). We also identified a locus on chromosome 12 (rs2900333, OR=1.27, P=6.16x10(-10)) that contains ATF7IP, a regulator of TERT expression. Finally, we identified a locus on chromosome 9 (rs755383, OR=1.37, P=1.12x10(-23)), containing the sex determination gene DMRT1, which has been linked to teratoma susceptibility in mice.
Turnbull
Clare
C
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK. clare.turnbull@icr.ac.uk
Rapley
Elizabeth A
EA
Seal
Sheila
S
Pernet
David
D
Renwick
Anthony
A
Hughes
Deborah
D
Ricketts
Michelle
M
Linger
Rachel
R
Nsengimana
Jeremie
J
Deloukas
Panagiotis
P
Huddart
Robert A
RA
Bishop
D Timothy
DT
Easton
Douglas F
DF
Stratton
Michael R
MR
Rahman
Nazneen
N
D000328:Adult; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
C501309:ATF7IP protein, human; C110547:DMRT1 protein; D012097:Repressor Proteins; D014157:Transcription Factors; C509186:TERT protein, human; D019098:Telomerase