title: [The significance of TGF-beta expression in scar in adenosine receptor A(2A) knockout mice].
abstract: OBJECTIVE
  To discuss the mechanism of scar hypertrophy in adenosine receptor A(2A) (A(2A) R) knockout mice.
  
  
  METHODS
  Animal models of hypertrophic scar were established in 12 A(2A) R knockout mice and 12 wild-type mice as control. The thickness and the size of transverse section of the hypertrophic scar were observed by H-E staining. The hydroxyproline (HYP) in the scar was measured colorimetrically. The TGF-beta expression was tested by Western blotting method.
  
  
  RESULTS
  The hypertrophic scar in wild-type mice was more severe than that in knockout mice. Compared with self-control, the increase of the thickness and the size of transverse section of hypertrophic scar was markedly higher in wild-type group than in the knockout group (P < 0.01). There was significant difference in HYP content between the two groups (P < 0.01). Compared with self-control, the increase of TGF-beta expression in wild-type group was much more than that in knockout group (P < 0.01).
  
  
  CONCLUSIONS
  The TGF-beta expression decreases in the A(2A) R knockout mice. The scar hypertrophy is also much less in the A(2A) R knockout mice.
authors.affiliation: Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Ran
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Zhuo
authors.forename: De-chang
authors.initials: DC
authors.lastname: Wang
authors.forename: Ran
authors.initials: R
authors.lastname: Huo
authors.forename: Yi-bing
authors.initials: YB
authors.lastname: Wang
authors.forename: Yong-qiang
authors.initials: YQ
authors.lastname: Feng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D051379:Mice; D018345:Mice, Knockout; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: D043705:Receptor, Adenosine A2A; D016212:Transforming Growth Factor beta