title: Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk.
abstract: Inflammation is postulated to play an important role in ovarian carcinogenesis. Prostaglandin endoperoxide synthase 2 (PTGS2) is responsible for the conversion of arachidonic acid to prostaglandins in response to inflammation. In a pooled analysis of two population-based studies, the Hawaii Ovarian Cancer Case-Control Study and the New England Case-Control Study, including 1,025 women with invasive ovarian carcinoma and 1,687 cancer-free controls, the association of ovarian cancer risk with the PTGS2 rs5275 polymorphism and the use of nonsteroidal antiinflammatory drugs (NSAIDs) were examined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. In the pooled analysis, the CC genotype was associated with a reduced risk of nonserous ovarian carcinoma (OR = 0.66; CI: 0.44-0.98). In addition, the lowest risk was observed among carriers of the CC genotype who were users of only nonaspirin NSAIDs (OR = 0.43; CI:0.20-0.93) in all women combined. The association of PTGS2 rs5275 with nonserous ovarian carcinoma and possible effect modification by NSAID use needs further validation, preferably in prospective studies.
authors.affiliation: Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA. glurie@CRCH.hawaii.edu
authors.forename: Galina
authors.initials: G
authors.lastname: Lurie
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Terry
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Thompson
authors.forename: Katharine E
authors.initials: KE
authors.lastname: McDuffie
authors.forename: Michael E
authors.initials: ME
authors.lastname: Carney
authors.forename: Rachel T
authors.initials: RT
authors.lastname: Palmieri
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Cramer
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009511:New England / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D051546:Cyclooxygenase 2