SRMS142-based solid lipid microparticles: application in oral delivery of glibenclamide to diabetic rats.
P90Gylation refers to the modification of lipid molecules by one or more phospholipid chains. Phospholipon 90G (P90G) contains about 94.0% of phosphatidylcholine stabilized with 0.1% ascorbyl palmitate and is a safe (GRAS) FDA-approved parenteral excipient with wide applications in drug delivery. P90Gylated-Softisan 142 conjugate, otherwise referred to as (SRMS142), has numerous advantages: wetting, solubilization, drug stabilization, emulsification, and modified release. Here, we report an evaluation of solid lipid microparticles (SLMs) formulated from SRMS142 systems as an alternative carrier system for oral glibenclamide administration in diabetic rats. The result of our findings showed that SRMS142 generated an imperfect matrix with numerous spaces that accommodated glibenclamide in a concentration-dependent manner up to 60.58%. The blood glucose-lowering effect of the SLMs was higher than that of a commercial sample.
Nnamani
P O
PO
Department of Pharmaceutics, University of Nigeria, Enugu State, Nigeria. obiomaeze@yahoo.com
Attama
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Ibezim
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EC
Adikwu
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MU
D000284:Administration, Oral; D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D001786:Blood Glucose / Q000187:drug effects*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D004337:Drug Carriers; D004339:Drug Compounding; D005905:Glyburide / Q000008:administration & dosage* / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
D001786:Blood Glucose; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007004:Hypoglycemic Agents; D010713:Phosphatidylcholines; D001205:Ascorbic Acid; C031226:6-O-palmitoylascorbic acid; D005905:Glyburide