Modulation of natural killer cell activity by viruses.
Since their discovery, our understanding of NK cells has evolved from branding them marginal innate immunity cells to key players in anti-viral and anti-tumor immunity. Importance of NK cells in control of various viral infections is perhaps best illustrated by the existence of plethora of viral mechanisms aimed to modulate their function. These mechanisms include not only virally encoded immunoevasion proteins but also viral miRNA. Moreover, the evidence has been accumulated supporting the role of viral immunoevasion of NK cells in viral pathogenesis in vivo.
Lisnić
Vanda Juranić
VJ
Department for Histology and Embryology and Center for Proteomics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
Krmpotić
Astrid
A
Jonjić
Stipan
S
D000818:Animals; D006801:Humans; D057131:Immune Evasion; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology; D035683:MicroRNAs / Q000276:immunology / Q000378:metabolism; D011506:Proteins / Q000276:immunology / Q000378:metabolism; D012367:RNA, Viral / Q000276:immunology / Q000378:metabolism; D055607:Receptors, Natural Killer Cell / Q000276:immunology / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology / Q000821:virology*; D014780:Viruses / Q000276:immunology*
D035683:MicroRNAs; D011506:Proteins; D012367:RNA, Viral; D055607:Receptors, Natural Killer Cell