title: Rhinoscleroma causing severe bilateral nasal obstruction.
abstract: Rhinoscleroma is a chronic, infectious and granulomatous disease of the respiratory tract. There is often a delay in diagnosis due to unfamiliarity with the disease and also because culture is not always positive. We report a case in a 26-year-old woman with granular mass obstructing bilateral nasal cavities and causing breathing difficulty. Histopathological examination showed characteristic Mikulicz histiocytes containing numerous Gram-negative intracellular rod-shaped bacilli consistent with the diagnosis of rhinoscleroma. The patient was treated with gemifloxacin and tetracycline and remains asymptomatic over a year follow-up period. It is important to consider rhinoscleroma in cases of chronic nasal obstruction. As culture is not always positive, histopathological examination may be crucial to the diagnosis.
authors.affiliation: Department of Pathology, Hospital Universitário de Brasília, UNB Via L2 Norte, Brasília, Brazil.
authors.forename: Mário Augusto Pinto de
authors.initials: MA
authors.lastname: Moraes
authors.forename: Albino Verçosa de
authors.initials: AV
authors.lastname: Magalhães
authors.forename: Larissa Cardoso
authors.initials: LC
authors.lastname: Marinho
authors.forename: Ana Emília Borges de
authors.initials: AE
authors.lastname: Azevedo
authors.forename: Fabiana Pirani
authors.initials: FP
authors.lastname: Carneiro
authors.forename: Igor Teixeira
authors.initials: IT
authors.lastname: Raymundo
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D000077735:Gemifloxacin; D006801:Humans; D009287:Naphthyridines / Q000627:therapeutic use; D015508:Nasal Obstruction / Q000188:drug therapy / Q000209:etiology*; D012226:Rhinoscleroma / Q000150:complications* / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D013752:Tetracycline; D000077735:Gemifloxacin