title: Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12, 0.85) with 25(OH)D concentrations of > or =75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.
authors.affiliation: Mercy Medical Center, Baltimore, Maryland 21202, USA. lgallic@mdmercy.com
authors.forename: Lisa
authors.initials: L
authors.lastname: Gallicchio
authors.forename: Lee E
authors.initials: LE
authors.lastname: Moore
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Stevens
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Ahn
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Virginia
authors.initials: V
authors.lastname: Hartmuller
authors.forename: V Wendy
authors.initials: VW
authors.lastname: Setiawan
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: David S
authors.initials: DS
authors.lastname: Campbell
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Karen L
authors.initials: KL
authors.lastname: Koenig
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000453:epidemiology* / Q000517:prevention & control*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D016015:Logistic Models; D008297:Male; D015201:Meta-Analysis as Topic; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D014807:Vitamin D