Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Case-control studies generally suggesting an inverse association between sun exposure and non-Hodgkin lymphoma (NHL) have led to speculation that vitamin D may protect against lymphomagenesis. To examine this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D (25(OH)D) and subsequent NHL risk within 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. The authors analyzed measurements from 1,353 cases and 1,778 controls using conditional logistic regression and other methods to estimate the association of 25(OH)D with NHL. No clear evidence of association between categories of 25(OH)D concentration and NHL was observed overall (P(trend) = 0.68) or by sex (men, P(trend) = 0.50; women, P(trend) = 0.16). Findings for other measures (continuous log(25(OH)D), categories of 25(OH)D using sex-/cohort-/season-specific quartiles as cutpoints, categories of season-adjusted residuals of predicted 25(OH)D using quartiles as cutpoints) were generally null, although some measures of increasing 25(OH)D were suggestive of an increased risk for women. Results from stratified analyses and investigations of histologic subtypes of NHL were also null. These findings do not support the hypothesis that elevated circulating 25(OH)D concentration is associated with a reduced risk of NHL. Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects.
Purdue
Mark P
MP
National Cancer Institute, Bethesda, Maryland, USA.
Freedman
D Michal
DM
Gapstur
Susan M
SM
Helzlsouer
Kathy J
KJ
Laden
Francine
F
Lim
Unhee
U
Maskarinec
Gertraud
G
Rothman
Nathaniel
N
Shu
Xiao-Ou
XO
Stevens
Victoria L
VL
Zeleniuch-Jacquotte
Anne
A
Albanes
Demetrius
D
Bertrand
Kimberly
K
Weinstein
Stephanie J
SJ
Yu
Kai
K
Irish
Lonn
L
Horst
Ronald L
RL
Hoffman-Bolton
Judith
J
Giovannucci
Edward L
EL
Kolonel
Laurence N
LN
Snyder
Kirk
K
Willett
Walter
W
Arslan
Alan A
AA
Hayes
Richard B
RB
Zheng
Wei
W
Xiang
Yong-Bing
YB
Hartge
Patricia
P
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000517:prevention & control*; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012621:Seasons; D013472:Sunlight; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
D014807:Vitamin D