title: [Antimicrobial activity of meropenem against main bacterial species isolated from patient blood in 2008].
abstract: We examined the antimicrobial activities of meropenem and other antibiotics against main bacteria isolated from patient blood in Keio university hospital between January and November in 2008. A total of 187 isolates, including 43 Escherichia coli, 23 Klebsiella pneumoniae, 9 Enterobacter cloacae, 22 Pseudomonas aeruginosa, 16 methicillin-susceptible Staphylococcus aureus (MSSA), 24 methicillin-resistant Staphylococcus aureus (MRSA), 50 Staphylococcus epidermidis were tested. Meropenem showed the potent and stable antibacterial activity against Gram-negative bacteria especially compared with our previous testing data. These results suggested that meropenem was first-line antibiotic for serious infections, although over 12 years passed after meropenem was approved in Japan.
authors.affiliation: Division of Clinical Microbiology, Department of Clinical Laboratories, Keio University Hospital.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sumitani
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katohno
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000097:blood / Q000382:microbiology*; D001769:Blood / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D000077731:Meropenem; D013845:Thienamycins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem