title: Investigating activity in hospitalized patients with chronic obstructive pulmonary disease: a pilot study.
abstract: OBJECTIVE
  This study examined therapeutic mobility activity, and investigated whether serum levels of inflammatory biomarkers interleukin (IL)-6 and IL-10 varied between periods of rest and activity.
  
  
  METHODS
  This observational, exploratory study took place in a medical intensive care unit and in stepdown units at an urban, academic medical center managed by intensivists. Our sample included 17 adults with exacerbations of chronic obstructive pulmonary disease (COPD).
  
  
  RESULTS
  Our results indicate that activity can occur for about 20 minutes, early during a hospitalization, among critically ill adults with COPD exacerbations, and activity can progress safely over 2 days in an intensive-care or stepdown setting. Physical activity was low in intensity, as measured by actigraphy.
  
  
  CONCLUSIONS
  Although no significant differences were evident between serum inflammatory biomarkers at rest vs after activity in this small sample, trend-related data indicate that low-intensity activity has the potential to alter the inflammatory profile of hospitalized COPD adults.
authors.affiliation: Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio 44106, USA. Chris.Winkelman@case.edu
authors.forename: Chris
authors.initials: C
authors.lastname: Winkelman
mesh_terms: D018806:APACHE; D056044:Actigraphy; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016638:Critical Illness; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009820:Ohio; D010865:Pilot Projects; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000451:nursing / Q000473:pathology*; D012146:Rest; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D016753:Interleukin-10