title: Engineered bone by autologous osteoblasts on polymeric scaffolds in maxillary sinus augmentation: histologic report.
abstract: Several regenerative therapies have been used for maxillary sinus grafting. However, recent advances in modern bone tissue engineering techniques have been evaluated. The aim of this histologic report was to evaluate the bone obtained by a culture of autogenous osteoblasts seeded on polyglycolic-polylactid scaffolds in maxillary sinus augmentation. A 56-year-old partially edentulous male with severe atrophy of the posterior maxilla received 6 polyglycolid-polylactid disks (8 mm diameter × 2 mm depth, Oral Bone), each carrying 1.5 million autogenous osteoblasts into the depth of the sinus cavity. After 6 months healing, a bone core was harvested and histologically evaluated. The augmented maxillary sinus with engineered bone presented a mean of 28.89% and 71.11% of bone and medullary spaces, respectively. Data from this case report demonstrate that the newly formed bone provided by engineered bone tissue allowed proper initial stability for dental implant placement. However, the role of this new bone in the long-term success of dental implant anchorage needs further investigation.
authors.affiliation: Department of Biomaterial Sciences, Insubria University, Varese, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Mangano
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Lucia
authors.initials: L
authors.lastname: Tettamanti
authors.forename: Francesco
authors.initials: F
authors.lastname: Mangano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mangano
authors.forename: Fábio
authors.initials: F
authors.lastname: Borges
authors.forename: Giovanna
authors.initials: G
authors.lastname: Iezzi
authors.forename: Susana
authors.initials: S
authors.lastname: d'Avila
authors.forename: Jamil Awad
authors.initials: JA
authors.lastname: Shibli
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001672:Biocompatible Materials / Q000737:chemistry; D001706:Biopsy; D015519:Bone Density / Q000502:physiology; D018929:Cell Culture Techniques; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D006801:Humans; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D010006:Osteoblasts / Q000473:pathology / Q000637:transplantation*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid