MicroRNAs in vascular biology and vascular disease.
MicroRNAs (miRNAs) have emerged as a novel class of endogenous, small, non-coding RNAs that negatively regulate over 30% of genes in a cell via degradation or translational inhibition of their target mRNAs. Functionally, an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes. Recent studies have identified that miRNAs are highly expressed in vasculature and their expression is deregulated in diseased vessels. miRNAs are found to be critical modulators for vascular cell functions such as cell differentiation, migration, proliferation, and apoptosis. Accordingly, miRNAs are involved in the angiogenesis and in the pathogenesis of vascular diseases. miRNAs may serve as novel biomarkers and therapeutic targets for vascular disease. This review article summarizes the research progress regarding the roles of miRNAs in vascular biology and vascular disease.
Zhang
Chunxiang
C
RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB-E548, Newark, NJ 07101, USA. zhangc3@umdnj.edu
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000235:genetics; D014652:Vascular Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology
D035683:MicroRNAs