Comparison of a gel versus solution-based vehicle for the delivery of acetylcholine in QSART.
Quantitative Sudomotor Axon Reflex Testing is a useful measure of post ganglionic sudomotor function. The test is based on the iontophoresis of an acetylcholine solution which induces a local sweat response. We have previously described a gel-based vehicle that may provide another option for the iontophoresis of acetylcholine. It was our objective to compare the influence of the vehicle (gel versus solution) on sudomotor recordings and perceived discomfort. Results show gel-based vehicles are very similar to solution-based vehicles during Quantitative Sudomotor Axon Reflex Testing.
Sletten
David M
DM
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States.
Kimpinski
Kurt
K
Weigand
Stephen D
SD
Low
Phillip A
PA
D000109:Acetylcholine / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D001369:Axons / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000009:adverse effects / Q000379:methods; D004568:Electrodiagnosis / Q000379:methods*; D005260:Female; D005782:Gels / Q000008:administration & dosage*; D006801:Humans; D007478:Iontophoresis / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013546:Sweating / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
D005782:Gels; D000109:Acetylcholine