A case of chronic hepatitis C developing insulin-dependent diabetes, thyroid autoimmunity and stiff-person syndrome as complications of interferon therapy.
We describe the case of a 66-year-old man with chronic hepatitis C who developed type 1 diabetes mellitus (T1DM) and thyroid autoimmunity during Interferon alpha (INFalpha) therapy and then stiff-person syndrome (SPS). This is the first reported case in which SPS has appeared as complication of IFNalpha therapy.
Scavone
G
G
Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy. jekoide80@yahoo.it
Zaccardi
F
F
Manto
A
A
Caputo
S
S
Pitocco
D
D
Ghirlanda
G
G
D000368:Aged; D015551:Autoimmunity / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D016750:Stiff-Person Syndrome / Q000139:chemically induced*; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology
D016898:Interferon-alpha