Facile synthesis of beta-cyclodextrin-dextran polymers by "click" chemistry.
Three series of novel water-soluble beta-cyclodextrin-dextran polymers have been prepared by "click" chemistry. The polymers were synthesized from alkyne-modified dextrans (AMDs) onto which mono-6-O-deoxy-monoazido-betaCD (N3betaCD) was grafted by a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The polymers have been characterized by NMR spectroscopy and size exclusion chromatography (SEC). The binding properties have been characterized by isothermal titration calorimetry (ITC) and show excellent accessibility of the betaCDs.
Nielsen
Thorbjørn Terndrup
TT
Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
Wintgens
Véronique
V
Amiel
Catherine
C
Wimmer
Reinhard
R
Larsen
Kim Lambertsen
KL
D002151:Calorimetry; D002850:Chromatography, Gel; D003911:Dextrans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D055601:Organic Chemistry Phenomena; D011108:Polymers / Q000138:chemical synthesis*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D003911:Dextrans; D011108:Polymers; D047392:beta-Cyclodextrins