title: No significant association between RELN polymorphism and autism in case-control and family-based association study in Chinese Han population.
abstract: The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. Both case-control analysis and transmission disequilibrium test (TDT) found no evidence of significant association. The results do not support previous positive findings and suggest that the four single-nucleotide polymorphisms (SNP) of RELN are unlikely to be associated with childhood autism in Chinese Han population.
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha, Hunan, China.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: He
authors.forename: Guanglei
authors.initials: G
authors.lastname: Xun
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Hu
authors.forename: Luxian
authors.initials: L
authors.lastname: Lv
authors.forename: Zemin
authors.initials: Z
authors.lastname: Deng
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001321:Autistic Disorder / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China / Q000208:ethnology; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000235:genetics*; D055815:Young Adult
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; D012697:Serine Endopeptidases