[The endothelin system: its involvement in the cardiovascular system].
The endothelin (ET)-system is composed of three endothelins, two receptors and two enzymes. The study of this system presents a great interest to understand the cardiovascular physiopathology. The ET-system is involved in cardiac organogenesis, angiogenesis and vascular tone homeostasis. Its role in arterial pulmonary hypertension, arterial hypertension and atherosclerosis has been shown. The numerous ET-system's targets suggest that it could be involved in pathologies which bring together various cardiovascular disorders such as the obstructive sleep apnoea syndrome. Thus, the ET-system generates today a lively interest for experimental and clinical trials.
Belaidi
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Laboratoire HP2, hypoxie et physiopathologies cardiovasculaires et respiratoires, EA-3745, Inserm ERI0017, France. elise.belaidi@recherche.univ-lyon1.fr
Godin-Ribuot
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D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D002986:Clinical Trials as Topic; D019332:Endothelin-1 / Q000627:therapeutic use; D016232:Endothelins / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D038081:Organogenesis; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy
D019332:Endothelin-1; D016232:Endothelins