title: [Determination and confirmation of cyanuric acid in infant formula using mixed-mode solid-phase extraction cartridge clean up-gas chromatography-mass spectrometry].
abstract: A method is presented for the quantitative determination and confirmation of cyanuric acid in infant formula by mixed-mode solid-phase extraction cartridge clean up-gas chromatography-mass spectrometry (GC-MS). Cyanuric acid was extracted from infant formula with an acetic acid solution at 84 degrees C. An aliquot of the supernatant was cleaned up using mixed-mode solid-phase extraction cartridge containing C18 and graphitized carbon black (GCB), and evaporated to dryness under nitrogen. The residues were converted to trimethylsilyl derivatives, then determined by GC-MS in selected ion monitoring (SIM) mode. The linear range was from 0.01 -2 mg/L. The recoveries were 80% - 103% and the relative standard deviations were 7.7% - 14.5% in the spiked range of 0.25 -2.5 mg/kg. The limit of detection was 0.10 mg/kg and the limit of quantification was 0.25 mg/kg. The method is rapid, sensitive, accurate, specific, and rugged. It is suitable for the quantitative determination and confirmation of cyanuric acid in infant formula.
authors.affiliation: Technical Center of Xinjiang Entry-Exit Inspection and Quarantine Bureau, Urumqi 830063, China. ciqlfg@163.com
authors.forename: Fengge
authors.initials: F
authors.lastname: Li
authors.forename: Weiqin
authors.initials: W
authors.lastname: Yao
authors.forename: Yanhe
authors.initials: Y
authors.lastname: Tian
authors.forename: Hui
authors.initials: H
authors.lastname: Dou
authors.forename: Min
authors.initials: M
authors.lastname: Su
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Shen