title: Facile synthesis of beta-cyclodextrin-dextran polymers by "click" chemistry.
abstract: Three series of novel water-soluble beta-cyclodextrin-dextran polymers have been prepared by "click" chemistry. The polymers were synthesized from alkyne-modified dextrans (AMDs) onto which mono-6-O-deoxy-monoazido-betaCD (N3betaCD) was grafted by a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The polymers have been characterized by NMR spectroscopy and size exclusion chromatography (SEC). The binding properties have been characterized by isothermal titration calorimetry (ITC) and show excellent accessibility of the betaCDs.
authors.affiliation: Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
authors.forename: Thorbjørn Terndrup
authors.initials: TT
authors.lastname: Nielsen
authors.forename: Véronique
authors.initials: V
authors.lastname: Wintgens
authors.forename: Catherine
authors.initials: C
authors.lastname: Amiel
authors.forename: Reinhard
authors.initials: R
authors.lastname: Wimmer
authors.forename: Kim Lambertsen
authors.initials: KL
authors.lastname: Larsen
mesh_terms: D002151:Calorimetry; D002850:Chromatography, Gel; D003911:Dextrans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D055601:Organic Chemistry Phenomena; D011108:Polymers / Q000138:chemical synthesis*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D003911:Dextrans; D011108:Polymers; D047392:beta-Cyclodextrins