title: Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
abstract: A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE epsilon4 allele resulted in a global p value of 0.56.
authors.affiliation: Division of Research Strategy, University College London, London, UK. f.lescai@ucl.ac.uk
authors.forename: Francesco
authors.initials: F
authors.lastname: Lescai
authors.forename: Chiara
authors.initials: C
authors.lastname: Pirazzini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Agostino
authors.forename: Aurelia
authors.initials: A
authors.lastname: Santoro
authors.forename: Roberta
authors.initials: R
authors.lastname: Ghidoni
authors.forename: Luisa
authors.initials: L
authors.lastname: Benussi
authors.forename: Daniela
authors.initials: D
authors.lastname: Galimberti
authors.forename: Esposito
authors.initials: E
authors.lastname: Federica
authors.forename: Francesca
authors.initials: F
authors.lastname: Marchegiani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cardelli
authors.forename: Fabiola
authors.initials: F
authors.lastname: Olivieri
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tagliavini
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Filippo
authors.initials: F
authors.lastname: Martinelli Boneschi
authors.forename: Giuliano
authors.initials: G
authors.lastname: Binetti
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Quadri
authors.forename: Elio
authors.initials: E
authors.lastname: Scarpini
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000091363:Protocadherins; D044465:White People / Q000235:genetics
chemical_list: D053327:Apolipoprotein E4; D015820:Cadherins; C404498:PCDH11X protein, human; D000091363:Protocadherins