title: Aerobic fitness and multidomain cognitive function in advanced age.
abstract: BACKGROUND
  Studies generally describe the relationship between physical fitness and cognitive function by measuring only one or two specific cognitive tasks. In addition, in spite of the significant increase in life expectancy, the age of participants in these studies does not extend beyond a mean age of 70 years. This study was thus designed to examine the relationship between physical fitness and function in multiple cognitive domains in subjects older than those previously reported.
  
  
  METHODS
  Thirty-eight individuals, aged 65.3 to 85.3 years, performed a graded, progressive, maximal exercise test. Based on a median score of peak VO2, participants were divided into low-fitness and moderately-fit groups. Cognitive function was assessed by means of a computerized neuropsychological battery.
  
  
  RESULTS
  The moderately-fit group achieved significantly better scores on the global cognitive score (U = 97, p = 0.04), and a significant correlation was found between peak VO2 and attention, executive function, and global cognitive score (rs = .37, .39, .38 respectively). The trend for superior cognitive scores in the moderate-fitness compared to the low-fitness groups was unequivocal, both in terms of accuracy and reaction time.
  
  
  CONCLUSIONS
  Maintenance of higher levels of cardiovascular fitness may help protect against cognitive deterioration, even at an advanced age. An adequately powered randomized controlled trial should be performed to further evaluate this hypothesis.
authors.affiliation: School of Physical Education, The Zinman College of Physical Education and Sport Sciences, Wingate Institute, Israel. neyael@wincol.ac.il
authors.forename: Yael
authors.initials: Y
authors.lastname: Netz
authors.forename: Tzvi
authors.initials: T
authors.lastname: Dwolatzky
authors.forename: Yael
authors.initials: Y
authors.lastname: Zinker
authors.forename: Esther
authors.initials: E
authors.lastname: Argov
authors.forename: Ruth
authors.initials: R
authors.lastname: Agmon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001288:Attention; D003071:Cognition; D056344:Executive Function; D015444:Exercise / Q000523:psychology; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D010809:Physical Fitness / Q000523:psychology; D011569:Psychiatric Status Rating Scales