title: A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.
abstract: BACKGROUND
  Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and/or associated with disease, and may have utility in trans-ethnic mapping studies.
  
  
  RESULTS
  We present a novel pseudo Bayes factor (PBF) approach that assess differences in covariance of genotype frequencies from single nucleotide polymorphism (SNP) data from a genome-wide study. The magnitude of the PBF reflects the strength of evidence for a difference, while accounting for the sample size and number of SNPs, without the requirement for permutation testing to establish statistical significance. Application of the PBF to HapMap and Gambian malaria SNP data reveals regional LD differences, some known to be under selection.
  
  
  METHODS
  The PBF approach has been implemented in the BALD (Bayesian analysis of LD differences) C++ software, and is available from http://homepages.lshtm.ac.uk/tgclark/downloads.
authors.affiliation: Department of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, UK. taane.clark@lshtm.ac.uk
authors.forename: Taane G
authors.initials: TG
authors.lastname: Clark
authors.forename: Susana G
authors.initials: SG
authors.lastname: Campino
authors.forename: Elisa
authors.initials: E
authors.lastname: Anastasi
authors.forename: Sarah
authors.initials: S
authors.lastname: Auburn
authors.forename: Yik Y
authors.initials: YY
authors.lastname: Teo
authors.forename: Kerrin
authors.initials: K
authors.lastname: Small
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Rockett
authors.forename: Dominic P
authors.initials: DP
authors.lastname: Kwiatkowski
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Holmes
mesh_terms: D001499:Bayes Theorem; D016678:Genome; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D018401:Sample Size; D012984:Software