title: The role of hypoxia regulated microRNAs in cancer.
abstract: The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its targets points to a variety of roles for this, and other hypoxia-regulated miRNAs (HRMs), in tumour growth and survival. miR-210 expression correlates with poor survival in cancer patients, and shows promise for future use as a tumour marker or therapeutic agent. The role of miR-210 and other HRMs in cancer biology is the subject of this review.
authors.affiliation: Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: McCormick
authors.forename: Francesca M
authors.initials: FM
authors.lastname: Buffa
authors.forename: Jiannis
authors.initials: J
authors.lastname: Ragoussis
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Harris
mesh_terms: D015687:Cell Hypoxia; D006801:Humans; D007506:Iron-Sulfur Proteins / Q000378:metabolism; D035683:MicroRNAs / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D007506:Iron-Sulfur Proteins; D035683:MicroRNAs; D012333:RNA, Messenger