7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.
Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
Davis
Rohan A
RA
Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
Demirkiran
Ozlem
O
Sykes
Melissa L
ML
Avery
Vicky M
VM
Suraweera
Lekha
L
Fechner
Gregory A
GA
Quinn
Ronald J
RJ
D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*
C553907:7',8'-dihydroobolactone; D007783:Lactones; D011753:Pyrones; D014344:Trypanocidal Agents