Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50-<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.
Abnet
Christian C
CC
National Cancer Institute, Bethesda, Maryland 20852, USA. christian.abnet@nih.gov
Chen
Yu
Y
Chow
Wong-Ho
WH
Gao
Yu-Tang
YT
Helzlsouer
Kathy J
KJ
Le Marchand
Loïc
L
McCullough
Marjorie L
ML
Shikany
James M
JM
Virtamo
Jarmo
J
Weinstein
Stephanie J
SJ
Xiang
Yong-Bing
YB
Yu
Kai
K
Zheng
Wei
W
Albanes
Demetrius
D
Arslan
Alan A
AA
Campbell
David S
DS
Campbell
Peter T
PT
Hayes
Richard B
RB
Horst
Ronald L
RL
Kolonel
Laurence N
LN
Nomura
Abraham M Y
AM
Purdue
Mark P
MP
Snyder
Kirk
K
Shu
Xiao-Ou
XO
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
D014807:Vitamin D