title: A case of Aspergillus empyema successfully treated with combination therapy of voriconazole and micafungin: excellent penetration of voriconazole and micafungin into pleural fluid.
abstract: A 62-year-old man with empyema caused by Aspergillus fumigatus was successfully treated with a combination of voriconazole (VRCZ) and micafungin (MCFG). Data regarding the penetration of antifungal agents into pleural fluid are limited. Thus, we measured the concentration of VRCZ and MCFG in his plasma and pleural fluid. Penetration of VRCZ and MCFG into the pleural fluid was excellent. Therefore, the combination therapy using VRCZ and MCFG may contribute to successful management of Aspergillus empyema.
authors.affiliation: Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Kagoshima, Japan. tmatsuda@m2.kufm.kagoshima-u.ac.jp
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Matsuda
authors.forename: Yoshimizu
authors.initials: Y
authors.lastname: Koreeda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Mataki
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Taira
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noma
authors.forename: Ikkou
authors.initials: I
authors.lastname: Higashimoto
mesh_terms: D001232:Aspergillus fumigatus / Q000187:drug effects; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage* / Q000378:metabolism; D016724:Empyema, Pleural / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D010996:Pleural Effusion / Q000378:metabolism*; D055732:Pulmonary Aspergillosis / Q000188:drug therapy* / Q000378:metabolism; D011743:Pyrimidines / Q000008:administration & dosage* / Q000378:metabolism; D014230:Triazoles / Q000008:administration & dosage* / Q000378:metabolism; D065819:Voriconazole
chemical_list: D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole; D000077551:Micafungin