Synthesis and characterization of polyester conjugates of ciprofloxacin.
Two-, three-, four and six-arm, star-shaped poly(epsilon-caprolactone) and polylactide homopolymers were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol, dipentaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel polyester conjugates of ciprofloxacin. The structures of the polymers and conjugates were determined by means of GPC, MALDI-TOF MS, NMR and IR studies. The in vitro release of ciprofloxacin from obtained conjugates was investigated.
Sobczak
Marcin
M
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wp.pl
D002939:Ciprofloxacin / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry*
D004337:Drug Carriers; D011091:Polyesters; D002939:Ciprofloxacin