A power-law distribution of inter-spike intervals in renal sympathetic nerve activity in salt-sensitive hypertension-induced chronic heart failure.
To assess sympathetic variability in chronic heart failure (CHF), we evaluated a distribution of inter-spike intervals (ISIs) in renal sympathetic nerve activity (RSNA) in salt-sensitive hypertension-induced CHF (DSSH-CHF) rats. Dahl salt-sensitive rats were fed an 8% NaCl diet for 9 weeks to induce salt-sensitive hypertension-induced CHF. ISIs in RSNA were obtained from chronically instrumented conscious rats, and counts (frequency) and ranks of ISIs in RSNA were plotted with a histogram. We found that ISIs in RSNA followed a power-law distribution in rats, and the power-law distribution of ISIs for RSNA in DSSH-CHF rats was significantly different from that in normal rats. These results indicated that sympathetic variability may be significantly different between salt-sensitive hypertension-induced CHF and healthy individuals, which suggests that sympathetic variability may be used to predict abnormality of the sympathetic regulatory system.
Kemuriyama
Takehito
T
Department of Physiology, National Defense Medical College, Tokorozawa, Saitama, Japan. kemu@ndmc.ac.jp
Ohta
Hiroyuki
H
Sato
Yoshiaki
Y
Maruyama
Satoshi
S
Tandai-Hiruma
Megumi
M
Kato
Kazuo
K
Nishida
Yasuhiro
Y
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004562:Electrocardiography; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications*; D007668:Kidney / Q000294:innervation*; D051381:Rats; D020303:Rats, Inbred Dahl; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D013045:Species Specificity; D013564:Sympathetic Nervous System / Q000502:physiology*