title: Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa.
abstract: OBJECTIVE
  There is mixed evidence of association of serotoninergic genes with anorexia nervosa (AN), but substantial evidence for the involvement of serotonergic mechanisms in appetite control. This study was designed to investigate possible associations between the two subtypes of AN (Restricting-RAN, and Binge-purging-BPAN) and polymorphisms within five genes encoding for proteins involved in the serotoninergic system.
  
  
  METHODS
  In order to carry out this investigation we have conducted a case-control association study on 226 females meeting the criteria for AN, and 678 matched healthy females.
  
  
  RESULTS
  Our data show a significant association between polymorphisms with the gene encoding HTR2A with both AN subtypes, an association between polymorphisms within the genes encoding HTR1D and HTR1B with RAN, and an association between polymorphisms within the gene encoding HTR2C with BPAN. No associations were found for any polymorphisms of the serotonin transporter gene. This outcome indicates a substantial and complex inter-relationship between serotoninergic genes and AN.
  
  
  CONCLUSIONS
  Given these data we hypothesis that the expression or control of expression of several genes of the serotoninergic system, and interactions between these genes, could exert considerable influence over the specific symptomatology of the subtypes of AN.
authors.affiliation: Institute of Psychological Sciences, University of Leeds, Leeds, UK. k.kiezebrink@abertay.ac.uk
authors.forename: Kirsty
authors.initials: K
authors.lastname: Kiezebrink
authors.forename: Evleen T
authors.initials: ET
authors.lastname: Mann
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Bujac
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Stubbins
authors.forename: David A
authors.initials: DA
authors.lastname: Campbell
authors.forename: John E
authors.initials: JE
authors.lastname: Blundell
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications / Q000235:genetics*; D052018:Bulimia Nervosa / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics; D012701:Serotonin / Q000235:genetics*
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin