Role of oxidative stress in the pathogenesis of preeclampsia.
Hypertensive disorders of pregnancy are associated with an increased risk of maternal and fetal morbidity and mortality. The cause and the pathogenesis of the pregnancy-induced syndrome, preeclampsia, is still poorly understood. Published evidence of altered biomarkers for the endothelial dysfunction suggests that the initiating event in preeclampsia is the reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium. This review focuses on the role of free radicals in generating the oxidative stress taking antioxidants into consideration which tend to overcome it as well as the role of placenta in preeclamptic pregnancy.
Siddiqui
Imran A
IA
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11426, Kingdom of Saudi Arabia. siddiquiimra@gmail.com
Jaleel
Anila
A
Tamimi
Waleed
W
Al Kadri
Hanan M F
HM
D000975:Antioxidants / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
D000975:Antioxidants; D005609:Free Radicals