Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation.
The efflux pump inhibitor phenyl-arginine-beta-naphthylamide (PAbetaN) was paired with iron chelators 2,2'-dipyridyl, acetohydroxamic acid, and EDTA to assess synergistic activities against Pseudomonas aeruginosa growth and biofilm formation. All of the tested iron chelators synergistically inhibited P. aeruginosa growth and biofilm formation with PAbetaN. PAbetaN-EDTA showed the most promising activity against P. aeruginosa growth and biofilm formation.
Liu
Yang
Y
Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.
Yang
Liang
L
Molin
Søren
S
D015082:2,2'-Dipyridyl / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development*; D004151:Dipeptides / Q000494:pharmacology; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D004151:Dipeptides; D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; C419365:phenylalanine arginine beta-naphthylamide; C006358:acetohydroxamic acid; D015082:2,2'-Dipyridyl; D004492:Edetic Acid