Furostanol glycosides from the rhizomes of Helleborus orientalis.
Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 cells.
Mimaki
Yoshihiro
Y
Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. mimakiy@toyaku.ac.jp
Matsuo
Yukiko
Y
Watanabe
Kazuki
K
Sakagami
Hiroshi
H
D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D039322:Helleborus; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification*; D027343:Rhizome
D006027:Glycosides; D010936:Plant Extracts