title: Outcome of children with sickle cell disease admitted to intensive care - a single institution experience.
abstract: We retrospectively audited children with sickle cell disease (SCD) admitted to paediatric intensive care (PICU) at King's College Hospital between January 2000 and December 2008. Forty-six children with SCD were admitted, on 49 separate occasions. Ages ranged from 4 months to 15 years (median 7.6 years). Three children died in PICU, however two presented to hospital in cardiorespiratory arrest; overall mortality was 6%. The most common reason for admission was acute chest syndrome (43%). 88% of admissions required blood transfusion, of which 74% had exchange blood transfusions. The mortality among children with SCD admitted to PICU is low.
authors.affiliation: Department of Paediatric Haematology, King's College London School of Medicine, King's College Hospital, Denmark Hill, London, UK. jack.bartram@nhs.net
authors.forename: Jack L
authors.initials: JL
authors.lastname: Bartram
authors.forename: Swee L
authors.initials: SL
authors.lastname: Thein
authors.forename: Kate
authors.initials: K
authors.lastname: Gardner
authors.forename: Yaya
authors.initials: Y
authors.lastname: Egberongbe
authors.forename: Pam
authors.initials: P
authors.lastname: D'Silva
authors.forename: Susan E
authors.initials: SE
authors.lastname: Height
authors.forename: Moira C
authors.initials: MC
authors.lastname: Dick
authors.forename: Sandra
authors.initials: S
authors.lastname: O'Driscoll
authors.forename: David C
authors.initials: DC
authors.lastname: Rees
mesh_terms: D056586:Acute Chest Syndrome / Q000209:etiology; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001803:Blood Transfusion; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay / Q000706:statistics & numerical data; D012121:Respiration, Artificial; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002316:Cardiotonic Agents