title: TSLP polymorphisms are associated with asthma in a sex-specific fashion.
abstract: BACKGROUND
  Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion.
  
  
  METHODS
  We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS).
  
  
  RESULTS
  Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 × 10(-6) ). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 × 10(-4) ). Findings for rs2289276 were consistent in all cohorts except the FHS.
  
  
  CONCLUSIONS
  TSLP variants are associated with asthma in a sex-specific fashion.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Hunninghake
authors.forename: M E
authors.initials: ME
authors.lastname: Soto-Quirós
authors.forename: L
authors.initials: L
authors.lastname: Avila
authors.forename: H P
authors.initials: HP
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Lasky-Su
authors.forename: N
authors.initials: N
authors.lastname: Rafaels
authors.forename: I
authors.initials: I
authors.lastname: Ruczinski
authors.forename: T H
authors.initials: TH
authors.lastname: Beaty
authors.forename: R A
authors.initials: RA
authors.lastname: Mathias
authors.forename: K C
authors.initials: KC
authors.lastname: Barnes
authors.forename: J B
authors.initials: JB
authors.lastname: Wilk
authors.forename: G T
authors.initials: GT
authors.lastname: O'Connor
authors.forename: W James
authors.initials: WJ
authors.lastname: Gauderman
authors.forename: H
authors.initials: H
authors.lastname: Vora
authors.forename: J W
authors.initials: JW
authors.lastname: Baurley
authors.forename: F
authors.initials: F
authors.lastname: Gilliland
authors.forename: C
authors.initials: C
authors.lastname: Liang
authors.forename: J S
authors.initials: JS
authors.lastname: Sylvia
authors.forename: B J
authors.initials: BJ
authors.lastname: Klanderman
authors.forename: S S
authors.initials: SS
authors.lastname: Sharma
authors.forename: B E
authors.initials: BE
authors.lastname: Himes
authors.forename: C J
authors.initials: CJ
authors.lastname: Bossley
authors.forename: E
authors.initials: E
authors.lastname: Israel
authors.forename: B A
authors.initials: BA
authors.lastname: Raby
authors.forename: A
authors.initials: A
authors.lastname: Bush
authors.forename: A M
authors.initials: AM
authors.lastname: Choi
authors.forename: S T
authors.initials: ST
authors.lastname: Weiss
authors.forename: J C
authors.initials: JC
authors.lastname: Celedón
mesh_terms: D001249:Asthma / Q000235:genetics*; D044383:Black People / Q000235:genetics; D002648:Child; D015331:Cohort Studies; D003364:Costa Rica; D016207:Cytokines / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012727:Sex Characteristics; D044465:White People / Q000235:genetics; D000094632:Thymic Stromal Lymphopoietin; D001741:Black or African American
chemical_list: D016207:Cytokines; D000094632:Thymic Stromal Lymphopoietin