Malignant hepatic epithelioid hemangioendothelioma with rapid progression and fatal outcome.
A 46-year-old woman was admitted to our hospital because of pain in the right upper quadrant and dyspnea. Abdominal and chest computed tomography (CT) scans revealed areas of low attenuation in both hepatic lobes, left pleural effusion, and multiple nodules in both lungs. Laboratory data indicated disseminated intravascular coagulation. She developed rapidly progressive respiratory and hepatic failure despite intensive treatment including mechanical ventilation and died of respiratory failure 3 weeks after admission. Immunohistochemical analysis of liver necropsy and cytology of the left plural effusion stained positive for factor VIII-related antigen and CD31. Based on these observations, a diagnosis of hemangioendothelioma (EHE), a rare vascular tumor, was made. A rapid clinical course and fatal outcome, as in the present case, are rare clinical manifestations in EHE.
Komatsu
Yoshimichi
Y
The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. koma@suwa.jrc.or.jp
Koizumi
Tomonobu
T
Yasuo
Masanori
M
Urushihata
Kazuhisa
K
Yamamoto
Hiroshi
H
Hanaoka
Masayuki
M
Kubo
Keishi
K
Kawakami
Satoshi
S
Honda
Takayuki
T
Fujimoto
Keisaku
K
Hachiya
Tsutomu
T
D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008875:Middle Aged; D013997:Time Factors