title: Thiazolidinediones as a novel class of algicides against red tide harmful algal species.
abstract: This paper reports the synthesis of 28 thiazolidinedione derivatives along with their algicidal activity against microalgae causing harmful algal blooming. Among the 28 compounds tested, most showed effective algicidal activity against Heterosigma akashiwo, Chattonella marina, and Cochlodinium polykrikoides, while non-harmful algae were relatively tolerant to these thiazolidinedione derivatives. Compounds 6, 13, and 22 were the most potent against C. polykrikoides with IC₅₀ values <0.5 µM. Among the thiazolidinedione derivatives tested, compounds 7, 13, 27, and 28 were extremely competent and selective to C. polykrikoides with IC₅₀ values ranging from 0.1 to 2 µM, while C. marina and H. akashiwo showed an IC₅₀ value ranging from 30 to 130 µM. These results show that some thiazolidinedione derivatives can act as potent algicides against harmful algal blooms.
authors.affiliation: Department of Life Science and Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Yeon-Mi
authors.initials: YM
authors.lastname: Kim
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Thi Uyen
authors.initials: TU
authors.lastname: Duong
authors.forename: Gajanan S
authors.initials: GS
authors.lastname: Ghodake
authors.forename: Si Wouk
authors.initials: SW
authors.lastname: Kim
authors.forename: Eonseon
authors.initials: E
authors.lastname: Jin
authors.forename: Hoon
authors.initials: H
authors.lastname: Cho
mesh_terms: D056890:Eukaryota / Q000187:drug effects* / Q000254:growth & development; D057097:Harmful Algal Bloom / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione