title: Tissue distribution of the laminin beta1 and beta2 chain during embryonic and fetal human development.
abstract: Laminins are the major glycoproteins present in all basement membranes. Previously, we showed that perlecan is present during human development. Although an overview of mRNA-expression of the laminin beta1 and beta2 chains in various developing fetal organs is already available, a systematic localization of the laminin beta1 and beta2 chains on the protein level during embryonic and fetal human development is missing. Therefore, we studied the immunohistochemical expression and tissue distribution of the laminin beta1 and beta2 chains in various developing embryonic and fetal human organs between gestational weeks 8 and 12. The laminin beta1 chain was ubiquitously expressed in the basement membrane zones of the brain, ganglia, blood vessels, liver, kidney, skin, pancreas, intestine, heart and skeletal system. Furthermore, the laminin beta2 chain was present in the basement membrane zones of the brain, ganglia, skin, heart and skeletal system. The findings of this study support and expand upon the theory that these two laminin chains are important during human development.
authors.affiliation: Department of Prosthodontics, Georg-August-University Goettingen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Roediger
authors.forename: Nicolai
authors.initials: N
authors.lastname: Miosge
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Gersdorff
mesh_terms: D037881:Aborted Fetus / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology; D047109:Fetal Development / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007797:Laminin / Q000096:biosynthesis*; D009928:Organ Specificity; D038081:Organogenesis / Q000502:physiology
chemical_list: C478221:LAMB1 protein, human; D007797:Laminin; C058783:laminin beta2