Hypertension and hypercholesterolemia aggregate in nondiabetic children and adolescents with higher fasting plasma glucose levels.
OBJECTIVE
To investigate how hypertension and hypercholesterolemia aggregate at different fasting plasma glucose (FPG) levels in children aged 6-16 yr.


METHODS
In a nationwide survey conducted between 1992 and 2000, all schoolchildren aged 6-18 yr with abnormal results in repeated urine samples were included. In this study, we recruited 27 535 students aged 6- to 16-yr whose FPG levels were 90-125 mg/dL. Another 17 907 children were randomly selected as control from schoolchildren with FPG <90 mg/dL by stratification to reflect the age- and sex-specific proportion of the whole student population.


RESULTS
The risk of having hypertension or hypercholesterolemia increased at FPG level above 90 mg/dL compared with children with FPG <90 mg/dL [6-10 yr, odd ratios (OR) = 1.51 and 1.82 for FPG 90-99 and 100-125 mg/dL for girls, OR = 1.35 and 2.03 for FPG 90-99 and 100-125 mg/dL for boys; 10-16 yr, OR = 1.24 and 1.66 for FPG 90-99 and 100-125 mg/dL for girls, OR = 1.17 and 1.41 for FPG 90-99 and 100-125 mg/dL for boys, all p < 0.05]. The risk of having both hypertension and hypercholesterolemia elevated at FPG 100-125 mg/dL (6-10 yr, OR = 2.76 for girls and 2.75 for boys; 10-16 yr, OR = 2.19 for girls and 1.74 for boys, all p < 0.05).


CONCLUSIONS
Aggregation of hypertension, hypercholesterolemia, and abnormal glycemia was found at FPG level above 100 mg/dL, which supported the definition of abnormal glycemia in metabolic syndrome by the International Diabetes Federation in 10- to 16-yr-old children. These findings also suggest that this FPG cutoff is reasonable for 6- to 10-yr-old children.
Li
Hung-Yuan
HY
Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan.
Wei
Jung-Nan
JN
Ma
Wen-Ya
WY
Sung
Fung-Chang
FC
Lin
Mao-Shin
MS
Lin
Cheng-Hsin
CH
Chiang
Chuan-Chi
CC
Chuang
Lee-Ming
LM
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005215:Fasting; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D016017:Odds Ratio; D013624:Taiwan / Q000453:epidemiology
D001786:Blood Glucose