Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8(+) T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3(+) DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8(+) T cells through XCR1.
Yamazaki
Chihiro
C
Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Miyamoto
Rie
R
Hoshino
Katsuaki
K
Fukuda
Yuri
Y
Sasaki
Izumi
I
Saito
Masuyoshi
M
Ishiguchi
Hironori
H
Yano
Takahiro
T
Sugiyama
Takahiro
T
Hemmi
Hiroaki
H
Tanaka
Takashi
T
Hamada
Eri
E
Hirashima
Takeshi
T
Amakawa
Ryuichi
R
Fukuhara
Shirou
S
Nomura
Shosaku
S
Ito
Tomoki
T
Kaisho
Tsuneyasu
T
D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002460:Cell Line; D019744:Chemokines, C / Q000096:biosynthesis*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D019707:Receptors, Chemokine / Q000096:biosynthesis*; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis*
D016827:CD8 Antigens; D019744:Chemokines, C; D008024:Ligands; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled; C551408:XC chemokine receptor 1, mouse; C092390:XCL1 protein, human; C091671:XCR1 protein, human; C486249:Xcl1 protein, mouse