title: [CD80 and CD86 coreceptors expression on lymphocytes B in hypertrophied adenoids in children with otitis media with effusion].
abstract: OBJECTIVE
  The aim of this study was evaluation of the percentage and mean fluorescence intensity of lymphocytes B with expression CD80 and CD86 in hypertrophied adenoids in children with otitis media with effusion.
  
  
  METHODS
  Expression coreceptors CD80 and CD86 on lymphocytes B in adenoid tissue were estimated by flow cytometry method. 15 children with otitis media with effusion and 15 children with hypertrophied adenoid were tested.
  
  
  RESULTS
  This study showed significantly higher percentage of lymphocytes CD19+ CD80+ in children with otitis media with effusion (OME 1.42% +/- 0.91) than in comparative group with hypertrophied adenoids (AH 0.63% +/- 0.21). The receptor CD86 didn't show differences in expression on lymphocytes B between both examinated groups.
  
  
  CONCLUSIONS
  Low expression of CD80 and CD86 indicates that local immunity response in hypertrophied adenoids in children with otitis media with effusion is weakened. It can contribute to the otitis media with effusion.
authors.affiliation: Zaklad Laboratoryjnej Diagnostyki, Pediatrycznej Uniwersytetu Medycznego w Białymstoku. karol.cam@interia.pl
authors.forename: Karol
authors.initials: K
authors.lastname: Ratomski
authors.forename: Beata
authors.initials: B
authors.lastname: Zelazowska-Rutkowska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wysocka
authors.forename: Bozena
authors.initials: B
authors.lastname: Skotnicka
authors.forename: Edwina
authors.initials: E
authors.lastname: Kasprzycka
authors.forename: Bauer
authors.initials: B
authors.lastname: Ilona
mesh_terms: D000234:Adenoids / Q000276:immunology* / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D001402:B-Lymphocytes / Q000378:metabolism*; D018122:B7-1 Antigen / Q000378:metabolism*; D051940:B7-2 Antigen / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000276:immunology; D008297:Male; D010034:Otitis Media with Effusion / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D011044:Poland; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D018122:B7-1 Antigen; D051940:B7-2 Antigen