title: High prevalence of comorbidity of migraine in outpatients with panic disorder and effectiveness of psychopharmacotherapy for both disorders: a retrospective open label study.
abstract: We investigated the comorbidity rate of migraine in outpatients with panic disorder, and the efficacy of pharmacotherapy for both disorders. Fifty-four patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for panic disorder were recruited in the study. Forty-three patients were female, and their age ranged from 20 to 71 (38.8±11.2; mean±S.D.) years. Forty-one patients had agoraphobia. In these patients, we diagnosed migraine and other types of headache, using the International Classification of Headache Disorders, Second Edition (ICHD-II). Forty-three (79.6%) patients were diagnosed as having some type of headache; 33 (61.1%) migraine, 32 tension-type headache, and one cluster headache. In patients with migraine, treatment for panic disorder also improved their migraine in 19 (57.6%) patients. The mean onset age of panic disorder in patients with migraine was statistically significantly younger than that in non-migraine patients. The Clinical Global Impression Improvement (CGI-I) score of panic disorder was statistically significantly correlated with the CGI-I score of migraine. A high comorbidity rate (61.1%) of migraine was observed in outpatients with panic disorder, and our result suggests that treatment with antidepressants for panic disorder may also be effective for prophylaxis of migraine.
authors.affiliation: Department of Psychiatry, Tokyo Women's Medical University, Medical Center East, Tokyo, Japan. yamadaps@dnh.twmu.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Kumi
authors.initials: K
authors.lastname: Moriwaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Oiso
authors.forename: Jun
authors.initials: J
authors.lastname: Ishigooka
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000453:epidemiology*; D010045:Outpatients; D016584:Panic Disorder / Q000188:drug therapy* / Q000453:epidemiology*; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents