title: 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.
abstract: Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demirkiran
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Sykes
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Lekha
authors.initials: L
authors.lastname: Suraweera
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fechner
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C553907:7',8'-dihydroobolactone; D007783:Lactones; D011753:Pyrones; D014344:Trypanocidal Agents