title: Nitrogen-doped carbon nanotubes: high electrocatalytic activity toward the oxidation of hydrogen peroxide and its application for biosensing.
abstract: This study compares the electrocatalytic activity of nitrogen-doped carbon nanotubes (NCNTs) with multiwalled carbon nanotubes (MWCNTs). Results indicate that NCNTs possess a marked electrocatalytic activity toward oxygen reduction reaction (ORR) by an efficient four-electron process in the alkaline condition, while the process of MWCNTs is through a two-electron pathway. Meanwhile, NCNTs show a very attractive electrochemical performance for the redox reaction of hydrogen peroxide (H2O2) and could be employed as a H2O2 sensor at a low potential of +0.3 V. The sensitivity of the NCNT-based biosensor reaches 24.5 microA/mM, more than 87 times that of the MWCNT-based one. Moreover, NCNTs exhibit striking analytical stability and reproducibility, which enables a reliable and sensitive determination of glucose by monitoring H2O2 produced by an enzymatic reaction between glucose oxidase/glucose or choline oxidase/choline at +0.3 V without the help of the electron mediator. The NCNT-based glucose biosensor has a linear range from 2 to 140 microM with an extremely high sensitivity of 14.9 microA/mM, and the detection limit is estimated to be 1.2 microM at a signal-to-noise ratio of 3. The results indicate that the NCNTs are good nanostructured materials for potential application in biosensors.
authors.affiliation: State Key Laboratory of Bioelectronics, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210096, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xu
authors.forename: Shujuan
authors.initials: S
authors.lastname: Jiang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Hu
authors.forename: Songqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002384:Catalysis; D004553:Electric Conductivity; D004563:Electrochemistry; D004566:Electrodes; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D011725:Pyridines; D006861:Hydrogen Peroxide; D009584:Nitrogen; C023666:pyridine