[Progress on Sp1-like and Krüppel-like factors].
Sp1-like and Krüppel-like factors (Sp1/KLFs) are a family of zinc-finger proteins that are important components of transcriptional machinery in eukaryotic cells. Sp1/KLFs have highly conserved DNA binding domains at the carboxyl terminus that have three tandem zinc-finger motifs. Their amino terminal regions vary greatly and contain transcription regulatory domains that interact with co-regulators. By regulating the expression of a large number of genes containing GC-rich or CACCC promoters in a tissue-, cell- and developmental stage-specific manner, Sp1/KLFs may be involved in many biological processes, including cell proliferation, differentiation, apoptosis and neoplastic transformation. In this article, we reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs.
Xiong
Qian
Q
Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China. xiongq@big.ac.cn
Ruan
Xiu-Yan
XY
Fang
Xiang-Dong
XD
D000818:Animals; D002453:Cell Cycle; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology; D016329:Sp1 Transcription Factor / Q000737:chemistry / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology
D051741:Kruppel-Like Transcription Factors; D016329:Sp1 Transcription Factor