title: Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica.
abstract: The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly exhibits antioxidant, anticancer, and anti-inflammatory effects. A search for biologically active compounds in U. davidiana var. japonica extracts yielded bakuchiol, which we structurally identified on the basis of spectral data, including two-dimensional nuclear magnetic resonance spectroscopy and distortionless enhancement by polarization transfer. In our study, bakuchiol (50 microM) inhibited lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production in RAW 264.7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica.
authors.affiliation: Korea Food Research Institute, Seongnam, Republic of Korea. sychoi@kfri.re.kr
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Choi
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Won-Hee
authors.initials: WH
authors.lastname: Choi
authors.forename: Yeonmi
authors.initials: Y
authors.lastname: Lee
authors.forename: Youn Ock
authors.initials: YO
authors.lastname: Jo
authors.forename: Tae-Youl
authors.initials: TY
authors.lastname: Ha
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D015232:Dinoprostone / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D009569:Nitric Oxide / Q000276:immunology; D010636:Phenols / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D034403:Ulmus / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D010636:Phenols; D010936:Plant Extracts; D009569:Nitric Oxide; D015232:Dinoprostone; C012765:bakuchiol