title: Effects of the somatic ion channels upon spontaneous mechanical oscillations in hair bundles of the inner ear.
abstract: Decoupled hair bundles of the bullfrog (Lithobates catesbeianus) sacculus exhibit spontaneous oscillations in vitro. We examine the effect of the somatic electrical circuit upon active hair bundle motility. We found that innate bundle movements exhibit a complex profile with multiple periodicities. Inhibition of somatic ion channels using targeted neurotoxins and modified physiological solutions strongly affects the bundles' mechanical behavior, modifying the amplitude and the temporal characteristics of the oscillation profile.
authors.affiliation: Department of Physics and Astronomy, University of California, Los Angeles, 475 Portola Plaza, Los Angeles, CA 90095, USA.
authors.forename: D
authors.initials: D
authors.lastname: Ramunno-Johnson
authors.forename: C E
authors.initials: CE
authors.lastname: Strimbu
authors.forename: A
authors.initials: A
authors.lastname: Kao
authors.forename: L
authors.initials: L
authors.lastname: Fredrickson Hemsing
authors.forename: D
authors.initials: D
authors.lastname: Bozovic
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D007758:Ear, Inner / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000187:drug effects; D008564:Membrane Potentials; D009038:Motion; D009991:Oscillometry; D011188:Potassium / Q000378:metabolism*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*; D011892:Rana catesbeiana; D013997:Time Factors
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels; D011188:Potassium; D002118:Calcium