title: [Natural course of aortic valve stenosis in patients with normal and abnormal lipid profile].
abstract: OBJECTIVE
  Comparison of echocardiographic findings in AVS patients with and without hypercholesterolemia during 12 months' observation of AVS natural course.
  
  
  METHODS
  60 AVS patients who did not agree for operational treatment were divided into group A (n = 47) with high serum total cholesterol and into group B (n = 13) with normal plasma cholesterol.
  
  
  METHODS
  plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, tri-glycerides and lipoprotein (a) were measured every 12 months and echocardiographic evaluation of aortic valve was also done every 12 months.
  
  
  RESULTS
  Means total cholesterol did not change in group A, while increased in group B. HDL-cholesterol decreased in group A and LDL-cholesterol increased in group B. Mean TG and Lp(a) levels did not change in both groups. Increase in AOG max and AOG mean as well as V max were found only group A. LVPW syst increase was found in group A. LA diameter increased and AVA decreased only in group A.
  
  
  CONCLUSIONS
  The results may suggest risk factors similarity of AVS progression and atherosclerosis.
authors.affiliation: II Klinika Kardiologii Collegium Medicum, Uniwersytetu Jagiellońskiego. grasshoppers@interia.eu
authors.forename: Jolanta
authors.initials: J
authors.lastname: Swierszcz
authors.forename: Jacek S
authors.initials: JS
authors.lastname: Dubiel
authors.forename: Tomasz
authors.initials: T
authors.lastname: Milewicz
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sztefko
authors.forename: Danuta
authors.initials: D
authors.lastname: Galicka-Latała
authors.forename: Roman
authors.initials: R
authors.lastname: Pfitzner
authors.forename: Jan
authors.initials: J
authors.lastname: Wodniecki
authors.forename: Józef
authors.initials: J
authors.lastname: Krzysiek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D050356:Lipid Metabolism; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol