Hypoxia and metastasis in breast cancer.
In this review we summarize the evidence for a role for hypoxic response in the biology of metastasis, with a particular emphasis on the metastasis of breast cancer and the function of the hypoxia inducible factor (HIF).
Rundqvist
Helene
H
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, CA 92093, USA.
Johnson
Randall S
RS
D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D015687:Cell Hypoxia; D005260:Female; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D009362:Neoplasm Metastasis; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D051793:Hypoxia-Inducible Factor 1; D000099162:Endothelial PAS Domain-Containing Protein 1