Differential var gene expression in children with malaria and antidromic effects on host gene expression.
Among 62 children with mild malaria, cerebral malaria, or severe malarial anemia, we analyzed the transcription of different var gene types. There was no difference in parasitemia level or body temperature between groups. However, a significantly different expression pattern was observed in children with cerebral malaria, compared with that in patients in the other 2 groups: children with cerebral malaria had lower expression of the upsA subtype but higher expression of the upsB and upsC subtypes. Furthermore, expression of human genes responsive to tumor necrosis factor and hypoxia correlated with distinct ups types.
Kalmbach
Yvonne
Y
Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany.
Rottmann
Matthias
M
Kombila
Maryvonne
M
Kremsner
Peter G
PG
Beck
Hans-Peter
HP
Kun
Jürgen F J
JF
D000740:Anemia / Q000209:etiology / Q000382:microbiology; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D017931:DNA Primers; D005681:Gabon; D005786:Gene Expression Regulation; D015964:Gene Expression Regulation, Bacterial; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D016779:Malaria, Cerebral / Q000235:genetics*; D016778:Malaria, Falciparum / Q000235:genetics*; D018512:Parasitemia / Q000235:genetics; D010963:Plasmodium falciparum / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D015800:Protozoan Proteins / Q000235:genetics*; D014158:Transcription, Genetic
D017931:DNA Primers; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum