Genes predict village of origin in rural Europe.
The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30  km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals.
O'Dushlaine
Colm
C
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
McQuillan
Ruth
R
Weale
Michael E
ME
Crouch
Daniel J M
DJ
Johansson
Asa
A
Aulchenko
Yurii
Y
Franklin
Christopher S
CS
Polašek
Ozren
O
Fuchsberger
Christian
C
Corvin
Aiden
A
Hicks
Andrew A
AA
Vitart
Veronique
V
Hayward
Caroline
C
Wild
Sarah H
SH
Meitinger
Thomas
T
van Duijn
Cornelia M
CM
Gyllensten
Ulf
U
Wright
Alan F
AF
Campbell
Harry
H
Pramstaller
Peter P
PP
Rudan
Igor
I
Wilson
James F
JF
D005060:Europe; D005192:Family Health; D005828:Genetics, Population / Q000379:methods*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D012424:Rural Population