title: Improving Polyp Detection Algorithms for CT Colonography: Pareto Front Approach.
abstract: We investigated a Pareto front approach to improving polyp detection algorithms for CT colonography (CTC). A dataset of 56 CTC colon surfaces with 87 proven positive detections of 53 polyps sized 4 to 60 mm was used to evaluate the performance of a one-step and a two-step curvature-based region growing algorithm. The algorithmic performance was statistically evaluated and compared based on the Pareto optimal solutions from 20 experiments by evolutionary algorithms. The false positive rate was lower (p<0.05) by the two-step algorithm than by the one-step for 63% of all possible operating points. While operating at a suitable sensitivity level such as 90.8% (79/87) or 88.5% (77/87), the false positive rate was reduced by 24.4% (95% confidence intervals 17.9-31.0%) or 45.8% (95% confidence intervals 40.1-51.0%) respectively. We demonstrated that, with a proper experimental design, the Pareto optimization process can effectively help in fine-tuning and redesigning polyp detection algorithms.
authors.affiliation: Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD 20892-1182.
authors.forename: Adam
authors.initials: A
authors.lastname: Huang
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Summers
authors.forename: Nicholas
authors.initials: N
authors.lastname: Petrick
authors.forename: Amy K
authors.initials: AK
authors.lastname: Hara