title: Acid etching does not improve CoCrMo implant osseointegration in a canine implant model.
abstract: Induction of bone ingrowth by topographical changes to implant surfaces is an attractive concept. Topographical modifications achieved by acid etching are potentially applicable to complex 3D surfaces. Using clinically relevant implant models, we explored the effect of wet etching porous bead-coated CoCrMo. The study was designed as two paired animal experiments with 10 dogs. Each dog received four implants; one in each medial femoral condyle (loaded 0.75-mm-gap model) and one in each proximal tibia (press-fit). The implants were observed for 6 weeks and were evaluated by biomechanical pushout tests and histomorphometry. We found that wet etching porous bead-coated CoCrMo implants failed to improve implant performance. Moreover, a tendency towards increased fibrous tissue formation, decreased new bone formation, and decreased mechanical fixation was observed. Surface topography on implants is able to stimulate bone-forming cells, but the clinical performance of an implant surface perhaps relies more on 3D geometrical structure and biocompatibility. Caution should be exercised regarding the results of wet etching of porous bead-coated CoCrMo and there is a need for more preclinical trials.
authors.affiliation: Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark. Stig.Jakobsen@ki.au.dk
authors.forename: Stig S
authors.initials: SS
authors.lastname: Jakobsen
authors.forename: Jorgen
authors.initials: J
authors.lastname: Baas
authors.forename: Thomas
authors.initials: T
authors.lastname: Jakobsen
authors.forename: Kjeld
authors.initials: K
authors.lastname: Soballe
mesh_terms: D000818:Animals; D004285:Dogs; D019544:Equipment Failure Analysis; D005269:Femur / Q000601:surgery; D008422:Materials Testing; D016348:Osseointegration; D011474:Prosthesis Design; D013977:Tibia / Q000601:surgery