title: Clinical characteristics and surgical outcomes of patients presenting with meningiomas arising predominantly from the floor of the middle fossa.
abstract: BACKGROUND
  Little is known regarding meningiomas that primarily arise from the floor of the middle fossa as opposed to the sphenoid wing, the cavernous sinus, the anterior petrous ridge, or the lateral convexity dura.
  
  
  OBJECTIVE
  Given the relative paucity of literature addressing this disease entity, we review the University of California at San Francisco (UCSF) experience with these tumors.
  
  
  METHODS
  Between 1991 and 2006, 1228 patients were seen by neurosurgeons at UCSF for meningiomas of which 17 (1.1%) patients met our criteria for a "middle fossa floor" meningioma, of which 15 underwent first-time surgery and were included in this series. The most common presenting symptoms were headache (9 patients), seizures (6 patients), trigeminal nerve dysfunction (5 patients), hearing loss (5 patients), gait disturbance (5 patients), and cognitive decline (3 patients). All patients underwent surgical resection via frontotemporal craniotomy, with or without orbitozygomatic osteotomy.
  
  
  RESULTS
  We were able to achieve a Simpson grade 1 or 2 resection in 10 of 15 patients (67%). The operative morbidity was clustered in 5 patients, as 10 of 15 patients (67%) experienced no operative morbidity. There were 4 known clinical recurrences in this group at 5 years median follow-up. All patients had either higher grade tumors, or received a Simpson grade 3 or higher resection.
  
  
  CONCLUSIONS
  We present the clinical characteristics and surgical outcome of a series of patients presenting with meningiomas primarily arising from the concave floor of the middle cranial fossa. Given the relatively uncommon nature of these lesions, more investigation into the clinical behavior of this entity is warranted.
authors.affiliation: Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Sughrue
authors.forename: Tene
authors.initials: T
authors.lastname: Cage
authors.forename: Gopal
authors.initials: G
authors.lastname: Shangari
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Parsa
authors.forename: Michael W
authors.initials: MW
authors.lastname: McDermott
mesh_terms: D000328:Adult; D035301:Cranial Fossa, Middle / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery