title: Cell nucleus architecture in health and medicine: geometrical descriptors and their use in grid based case studies.
abstract: Adopting the world wide accessible Grid computing power and data management structures enables usage of large image data bases for individual diagnosis and therapy decisions. Here, we define several descriptors of the genome architecture of cell nuclei which are the basis of a detailed analysis for conclusions on the health state of an individual patient. All these descriptors can be accessed by automatic inspection of microscopic images of fluorescently labelled nuclei, obtained from cells from tissue sections or blood and subjected to standard biochemical protocols. We demonstrate how the combinatorial, geometrical and statistical parameters may be used in diagnosis and therapy monitoring.
authors.affiliation: Kirchhoff Institute of Physics, University of Heidelberg, Heidelberg, Germany.
authors.forename: Eberhard
authors.initials: E
authors.lastname: Schmitt
authors.forename: Patrick
authors.initials: P
authors.lastname: Müller
authors.forename: Stefan
authors.initials: S
authors.lastname: Stein
authors.forename: Jutta
authors.initials: J
authors.lastname: Schwarz-Finsterle
authors.forename: Michael
authors.initials: M
authors.lastname: Hausmann
mesh_terms: D002467:Cell Nucleus / Q000235:genetics / Q000648:ultrastructure*; D003195:Computer Communication Networks; D005453:Fluorescence; D018628:Gene Dosage; D006262:Health; D006801:Humans; D021621:Imaging, Three-Dimensional; D008511:Medicine; D013358:Subject Headings