[Analysis of the 14 bp insertion/deletion polymorphism in human leukocyte antigen-G gene in Chinese Dai and Han ethnic groups in Yunnan Province].
A 14 bp insertion/deletion polymorphism (+14 bp/-14 bp) in exon 8 of HLA-G gene has been investigated extensively because this polymorphism was associated with HLA-G mRNA stability and could influence HLA-G mRNA expression. In the present study, we genotyped 14 bp insertion/deletion polymorphisms in the HLA-G gene in Dai and Han populations in Yunnan Province. The frequencies of +14 bp in Dai and Han were 31.97% and 40.87%, respectively. The frequency of +14 bp/+14 bp in Dai was lower (8.20%) than that of Han (17.31%). Nevertheless, the frequency of +14 bp/-14 bp was similar in both populations (47.54% in Dai and 47.11% in Han). When compared with other populations, the frequency of 14 bp insertion/deletion of Han was similar to others, whereas the Dai showed significant difference from others and presented it's specific characteristic. We assumed that the distribution characteristic of 14 bp insertion/deletion in Dai might be the results of random genetic drift, but the role of natural selection cannot be excluded.
Chen
Jin-Bao
JB
Department of Medical Genetics, Institute of Medical Biology, Chinese Acadamy of Medical Sciences, Peking Union Medical College, Kunming 650118, China. chenjinbao666@126.com
Shi
Lei
L
Yao
Yu-Feng
YF
Shi
Li
L
Yu
Liang
L
Lin
Ke-Qin
KQ
Tao
Yu-Fen
YF
Yi
Wen
W
Huang
Xiao-Qin
XQ
Sun
Hao
H
Chu
Jia-You
JY
D002681:China / Q000208:ethnology; D005091:Exons; D005260:Female; D017353:Gene Deletion; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D016254:Mutagenesis, Insertional; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I