Rational manipulation of amyloidogenesis using an atomic level map of peptide-fibril interactions.
Amyloidogenic aggregation has been the subject of intense research over the past few decades, but the mechanisms underlying the early stages of amyloidogenesis remain elusive. Here we demonstrate for the first time manipulation of amyloidogenesis based on an atomic level map of peptide-fibril interactions in early- and late-stage ordered aggregation. Several point mutants with specific amyloidogenic properties are introduced, including one that "stalls" early in the aggregation process, forming early-stage fibrillar aggregates, but not mature fibrils.
Liang
Yanfang
Y
Department of Chemistry, York University, Toronto, Ontario M3J 1P6, Canada.
Jasbi
Shohreh Zahedi
SZ
Morin
Sylvie
S
Wilson
Derek J
DJ
D004347:Drug Interactions; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D017354:Point Mutation
D010455:Peptides