title: Synthesis of some novel hydrazono acyclic nucleoside analogues.
abstract: The syntheses of novel hydrazono acyclic nucleosides similar to miconazole scaffolds are described. In this series of acyclic nucleosides, pyrimidine as well as purine and other azole derivatives replaced the imidazole function in miconazole and the ether group was replaced with a hydrazone moiety using phenylhydrazine. To interpret the dominant formation of (E)-hydrazone derivatives rather than (Z)-isomers, PM3 semiempirical quantum mechanic calculations were carried out which indicated that the (E)-isomers had the lower heats of formation.
authors.affiliation: Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz 71555-313, Iran. soltani@sutech.ac.ir
authors.forename: Mohammad N
authors.initials: MN
authors.lastname: Soltani Rad
authors.forename: Ali
authors.initials: A
authors.lastname: Khalafi-Nezhad
authors.forename: Somayeh
authors.initials: S
authors.lastname: Behrouz