title: [Non-syndromic cleft lip/cleft palate and C677T methylene-tetrahydrofolate reductase variant in Mexican children].
abstract: BACKGROUND
  Non-syndromic cleft lip with or without cleft palate (NSCLP) is a common malformation. The aetiology is multifactorial. An incidence of 1.1-1.39 per 1000 new births had been reported in Mexico. The folic acid intake in preconceptional stage has been reported to prevent malformations such as neural tube defects (NTD) and NSCLP. The C677T variant of the methylene-tetrahydrofolate reductase (MTHFR) gene is responsible of a thermolabile form, related to decrease of folate and increase homocysteine. This variant has been associated with CLP, in different populations, but results are still controversial. Our objective was to determine the allelic (AF) and genotypic frequency (GF) of the MTHFR-C677T variant in Mexican children with NSCLP.
  
  
  METHODS
  Transverse comparative study in 67 Mexican children with NSCLP and a control group with 70 unrelated Mexican individuals without NSCLP.
  
  
  RESULTS
  The AF in NSCLP was 39 %. There was no statistical difference between AF in the two groups (39 versus 41).
  
  
  CONCLUSIONS
  In this population, genotype C677T was not a major risk factor for this malformation, however, sample size, other genes implicated and genes-environment interactions must be considered.
authors.affiliation: Centro de Investigación Biomédica de Occidente, Universidad de Guadalajara, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. ingriddavalos@hotmail.com
authors.forename: Ingrid Patricia
authors.initials: IP
authors.lastname: Dávalos-Rodríguez
authors.forename: Ernesto Javier
authors.initials: EJ
authors.lastname: Ramírez-Lizardo
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Mena
authors.forename: Víctor
authors.initials: V
authors.lastname: Ledezma-Rodríguez
authors.forename: Nory
authors.initials: N
authors.lastname: Omayra-Dávalos
authors.forename: Mirna Gisel
authors.initials: MG
authors.lastname: González-Mercado
authors.forename: Jorge
authors.initials: J
authors.lastname: Durán-González
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Morán-Moguel
authors.forename: Valeria
authors.initials: V
authors.lastname: Peralta-Leal
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Páramo
authors.forename: Víctor
authors.initials: V
authors.lastname: Ledezma-Gómez
mesh_terms: D002648:Child; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D003430:Cross-Sectional Studies; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)