title: Increased central adiposity in morbidly obese patients with obstructive sleep apnoea.
abstract: BACKGROUND
  With the growing epidemic of obesity, few data are available regarding adipose distribution and the severity of sleep apnoea. Our aim was to measure precisely adipose distribution with dual-energy X-ray absorptiometry (DXA) in a morbidly obese population with and without obstructive sleep apnoea (OSA).
  
  
  METHODS
  Morbidly obese female subjects without a history of OSA underwent overnight polysomnography and DXA analysis. Subject demographics, DXA variables, serum laboratory markers and physical exam characteristics were compared between individuals with and without OSA.
  
  
  RESULTS
  For the study population (n= 26), mean body mass index (BMI) was 45.9 ± 7.8 kg/m(2); mean age was 47.5 ± 10.2 years and all were female. The central adiposity ratio (CAR) was higher in individuals with OSA (apnoea-hypopnoea index > 5) than those without OSA (1.1 ± 0.05 vs 1.0 ± 0.04; P = 0.004). No difference was observed in Epworth Sleepiness Scale scores, body mass index (BMI) or neck circumference between groups.
  
  
  CONCLUSIONS
  OSA is associated with increased central adipose deposition in patients with a BMI of >40 kg/m(2). These data may be helpful in designing future studies regarding the pathophysiology of OSA, and potential treatment options.
authors.affiliation: Department of Medicine, Division of Cardiology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA. jeanellee_88@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Soriano-Co
authors.forename: T E
authors.initials: TE
authors.lastname: Vanhecke
authors.forename: B A
authors.initials: BA
authors.lastname: Franklin
authors.forename: R B
authors.initials: RB
authors.lastname: Sangal
authors.forename: B
authors.initials: B
authors.lastname: Hakmeh
authors.forename: P A
authors.initials: PA
authors.lastname: McCullough
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009767:Obesity, Morbid / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D017286:Polysomnography / Q000379:methods; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology