[Relationship of alloreactive NK cells to prognosis of HLA-identical sibling allogeneic hematopoietic stem cell transplantation].
In recent years, the interaction between HLA class I alleles and receptors of NK cells have been paid more attention in HLA-identical sibling hematopoietic stem cell transplantation (HLA-identical sibling HSCT). NK cells mediate alloreactions when the allogeneic targets do not express HLA class I alleles that block inhibitory receptors of NK cells. Alloreactive donor-derived NK cells reduce GVHD by eliminating host-type antigen-presenting cells, but favor engraftment by killing host lymphocyte cells and reduce the risk of relapse by eradicating leukemia cells. Moreover, activating receptors also influence the outcome of HLA-identical sibling HSCT. In this review, the advance of the impact of both inhibitory and activating KIR (killer cell immunoglobulin-like receptor, KIR) on the outcome of HLA-identical sibling HSCT is briefly summarized.
Peng
Bi-Yun
BY
Key Laboratory of Thrombosis and Hemostasis Subordinate to Ministry of Health, Jiangsu Institute of Hematology, Suzhou University First Hospital, Suzhou 215006, Jiangsu Province, China.
Tang
Xiao-Wen
XW
D006680:HLA Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D011379:Prognosis; D054340:Receptors, KIR / Q000276:immunology*; D035781:Siblings; D014184:Transplantation, Homologous
D006680:HLA Antigens; D054340:Receptors, KIR