[Lipid profile in obese and non-obese women with polycystic ovary syndrome treated with metformin].
OBJECTIVE
To compare lipid and lipoprotein concentrations between obese and non-obese women with a diagnosis of polycystic ovary syndrome (PCOS) treated with metformin for 6 months.


METHODS
Sixty-five women with a diagnosis of PCOS were included. The presence of obesity, serum concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were recorded before and after 6 months of metformin treatment. The women were divided in two groups of 34 obese women (group A; body mass index >27 kg/m(2)) and 31 non-obese women (group B; body mass index (<27 kg/m(2)).


RESULTS
Significant differences in body mass index, waist-hip ratio, cholesterol, triglycerides, LDL-c and HDL-c were found in group A compared with group B (p<0.05). In obese women, serum triglyceride and LDL-c concentrations were significantly reduced (p<0.05), while serum concentrations of HDL-c were significantly increased (p<0.05) after 6 months of treatment. In non-obese women, none of these lipid profile modifications were considered significant (p=ns).


CONCLUSIONS
Metformin use for 6 months modified triglyceride, LDL-c and HDL-c concentrations compared with initial values in obese women with PCOS while no significant modifications in lipid or lipoprotein concentrations were observed in non-obese women.
Quintero-Castillo
Daimarys
D
Servicio de Medicina Interna, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela. sippenbauch@gmail.com
Luz-Araujo
Hedy
H
Guerra-Velázquez
Mery
M
Reyna-Villasmil
Eduardo
E
Santos Bolívar
Joel
J
Torres-Cepeda
Duly
D
Mejia-Montilla
Jorly
J
Reyna-Villasmil
Nadia
N
D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008687:Metformin / Q000627:therapeutic use*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
D008074:Lipoproteins; D014280:Triglycerides; D008687:Metformin; D002784:Cholesterol