T regulatory cells and transplantation tolerance.
Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation. The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.
Gorantla
Vijay S
VS
Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Schneeberger
Stefan
S
Brandacher
Gerald
G
Sucher
Robert
R
Zhang
Dong
D
Lee
W P Andrew
WP
Zheng
Xin Xiao
XX
D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology; D023001:Transplantation Tolerance; D014184:Transplantation, Homologous / Q000276:immunology
D007166:Immunosuppressive Agents