Altered human neutrophil function in response to acute psychological stress.
OBJECTIVE
To examine the effects of an acute laboratory psychological stress task on neutrophil function, specifically phagocytosis of Escherichia coli and stimulated superoxide production in human neutrophils. There is mounting evidence that acute stress is associated with short-term increases in a number of immune indices.


METHODS
Participants were 40 (n = 20 females) university students (mean age, 25.9 ± 4.56 years). Blood samples to determine neutrophil function by flow cytometry were taken at the end of resting baseline, during an acute stress task, and during recovery. The stress task was a 10-minute time-pressured mental arithmetic challenge with social evaluation.


RESULTS
There was an acute increase in phagocytic ability, p = .047, η(2)p = 0.076, and a reduction of superoxide production, p = .026, η(2)p = 0.101, associated with the stress task relative to baseline.


CONCLUSIONS
These findings suggest that neutrophil bactericidal function may be sensitive to mental challenge tasks that provoke acute psychological stress. Further research is needed to replicate the observed psychological stress-induced changes in neutrophil function.
Khanfer
Riyad
R
School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United Kingdom.
Phillips
Anna C
AC
Carroll
Douglas
D
Lord
Janet M
JM
D000208:Acute Disease; D000328:Adult; D001770:Blood Bactericidal Activity / Q000276:immunology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005434:Flow Cytometry; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D013315:Stress, Psychological / Q000097:blood / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides