title: UV and near-IR triggered release from polymeric nanoparticles.
abstract: A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model pharmaceutical Nile Red. Triggered burst release of the payload upon irradiation and subsequent degradation of the nanoparticles were observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Nadezda
authors.initials: N
authors.lastname: Fomina
authors.forename: Cathryn
authors.initials: C
authors.lastname: McFearin
authors.forename: Marleen
authors.initials: M
authors.lastname: Sermsakdi
authors.forename: Osayimwense
authors.initials: O
authors.lastname: Edigin
authors.forename: Adah
authors.initials: A
authors.lastname: Almutairi
mesh_terms: D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D011108:Polymers