A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis.
A new protoberberine alkaloid, 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxo-protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine-induced contraction in isolated guinea-pig ileum with an IC50 of 83.7 microm.
Zhao
Ming
M
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong.
Xian
Yan-Fang
YF
Ip
Siu-Po
SP
Fong
Harry Hs
HH
Che
Chun-Tao
CT
D000109:Acetylcholine; D000818:Animals; D001600:Berberine Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D039323:Coptis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome
C556510:3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxoprotoberberine; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D010276:Parasympatholytics; D000109:Acetylcholine