title: Cembranolides from the stem bark of the southern African medicinal plant, Croton gratissimus (Euphorbiaceae).
abstract: The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines.
authors.affiliation: Division of Chemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK. D.mulholland@surrey.ac.uk
authors.forename: Dulcie A
authors.initials: DA
authors.lastname: Mulholland
authors.forename: Moses K
authors.initials: MK
authors.lastname: Langat
authors.forename: Neil R
authors.initials: NR
authors.lastname: Crouch
authors.forename: Helen M
authors.initials: HM
authors.lastname: Coley
authors.forename: Emily M
authors.initials: EM
authors.lastname: Mutambi
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nuzillard
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013019:South Africa; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes