title: Chromosome X aneuploidy in Brazilian schizophrenic patients.
abstract: The identification of cytogenetic abnormalities in schizophrenic patients may provide clues to the genes involved in this disease. For this reason, a chromosomal analysis of samples from 62 schizophrenics and 70 controls was performed with trypsin-Giemsa banding and fluorescence in situ hybridization of the X chromosome. A clonal pericentric inversion on chromosome 9 was detected in one male patient, and we also discovered mosaicism associated with X chromosome aneuploidy in female patients, primarily detected in schizophrenic and normal female controls over 40 years old. When compared with age-matched female controls, the frequency of X chromosome loss was not significantly different between schizophrenics and controls, except for the 40- to 49-year-old age group. Our findings suggest that the X chromosome loss seen in schizophrenic patients is inherent to the normal cellular aging process. However, our data also suggest that X chromosome gain may be correlated with schizophrenia in this Brazilian population.
authors.affiliation: Biomedicine, Federal University of Piauí, 64202-020 Parnaíba, PI, Brazil.
authors.forename: Leopoldo Silva
authors.initials: LS
authors.lastname: de Moraes
authors.forename: André Salim
authors.initials: AS
authors.lastname: Khayat
authors.forename: Patrícia Danielle Lima
authors.initials: PD
authors.lastname: de Lima
authors.forename: Eleonidas Moura
authors.initials: EM
authors.lastname: Lima
authors.forename: Giovanny Rebouças
authors.initials: GR
authors.lastname: Pinto
authors.forename: Mariana Ferreira
authors.initials: MF
authors.lastname: Leal
authors.forename: Marília
authors.initials: M
authors.lastname: de Arruda Cardoso Smith
authors.forename: Rommel Rodríguez
authors.initials: RR
authors.lastname: Burbano
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics; D000782:Aneuploidy; D001938:Brazil; D002869:Chromosome Aberrations; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D012559:Schizophrenia / Q000235:genetics*