The association of masked hypertension in treated type 2 diabetic patients with carotid artery IMT.
OBJECTIVE
To evaluate the association of masked hypertension (MH) in treated type 2 diabetic patients without history of cardiovascular disease with carotid artery target organ damage.


METHODS
Sixty-four type 2 diabetic patients treated for hypertension with office BP below 140/90 mm Hg were examined by 24-h BP monitoring and carotid sonography. MH was diagnosed if daily mean ambulatory BP was >or=135/85 mm Hg. The association of MH with carotid artery parameters was evaluated.


RESULTS
The average age of patients was 62+/-5 years. Twenty-four patients had MH (37.5%). Carotid artery IMT was 0.74+/-0.08 mm in patients with MH and 0.69+/-0.06 mm without MH (p=0.03). The distensibility of common carotid artery was 0.24+/-0.07 mmHg(-1) in patients with MH and 0.29+/-0.1mm Hg(-1) without MH (p=0.14). After adjustment for age, gender, smoking, duration of diabetes, BMI and clinic blood pressure (BP) values the association of MH with carotid artery IMT was sustained.


CONCLUSIONS
Masked hypertension in treated type 2 diabetic patients is associated with carotid artery IMT.
Charvat
Jiri
J
Medical department of 2nd Faculty Hospital of Charles University in Prague, Prague, Czech Republic. jiri.charvat@lfmotol.cuni.cz
Chlumsky
Jaromir
J
Szabo
Marcela
M
Zakovicova
Eva
E
Zamrazil
Vaclav
V
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002340:Carotid Artery Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents