title: Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974-2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50-<75 nmol/L as the reference category. Meta-analyses were also conducted using inverse-variance weights in random-effects models. This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations.
authors.affiliation: Mercy Medical Center, Baltimore, Maryland 21202, USA. lgallic@mdmercy.com
authors.forename: Lisa
authors.initials: L
authors.lastname: Gallicchio
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.forename: D Michal
authors.initials: DM
authors.lastname: Freedman
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Virginia
authors.initials: V
authors.lastname: Hartmuller
authors.forename: Chinonye
authors.initials: C
authors.lastname: Harvey
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Karen L
authors.initials: KL
authors.lastname: Koenig
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Francine
authors.initials: F
authors.lastname: Laden
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: Dominick
authors.initials: D
authors.lastname: Parisi
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
authors.forename: Shelley S
authors.initials: SS
authors.lastname: Tworoger
authors.forename: Arti
authors.initials: A
authors.lastname: Varanasi
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Christian C
authors.initials: CC
authors.lastname: Abnet
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Kimberly
authors.initials: K
authors.lastname: Bertrand
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D014807:Vitamin D