Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma.
Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-beta in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion.
Ye
Feng
F
Women's Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Rd#2, Hangzhou, 310006, China.
Yu
Yan
Y
Hu
Yuting
Y
Lu
Weiguo
W
Xie
Xing
X
D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000097:blood* / Q000276:immunology / Q000473:pathology
D016207:Cytokines