Chromosomal anomaly spectrum in early pregnancy loss in relation to presence or absence of an embryonic pole.
OBJECTIVE
To compare the cytogenetic findings in a series of missed miscarriages evaluated by chorionic villus sampling, in relation to embryonic pole presence (embryonic or anembryonic).


METHODS
Prospective cross-sectional study.


METHODS
Tertiary referral hospital.


METHODS
Women presenting with a missed miscarriage.


METHODS
Transcervical chorionic villus sampling and cytogenetic studies in the chorionic villi with use of the semidirect method.


METHODS
Embryonic pole presence or absence assessed by transvaginal ultrasound examination. Type of chromosomal anomalies found in both subgroups.


RESULTS
Although the chromosomal abnormality rate was similar for miscarriages with absent or present embryo (61% vs. 68% respectively), frequencies for viable autosomal trisomies (2.3% vs. 19%) and monosomy X (0% vs. 9.2%) were significantly lower when no embryonic pole was seen.


CONCLUSIONS
Viable autosomal trisomies and monosomies X appear not to be a common cause of miscarriage with an early fetal demise (anembryonic miscarriage).
Muñoz
Monica
M
Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, University of Barcelona Medical School, Barcelona, Spain.
Arigita
Marta
M
Bennasar
Mar
M
Soler
Anna
A
Sanchez
Aurora
A
Borrell
Antoni
A
D000030:Abortion, Missed / Q000453:epidemiology / Q000235:genetics; D000328:Adult; D015193:Chorionic Villi Sampling / Q000706:statistics & numerical data; D002869:Chromosome Aberrations; D003430:Cross-Sectional Studies; D020732:Cytogenetic Analysis; D020964:Embryo Loss / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D004622:Embryo, Mammalian / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008875:Middle Aged; D020897:Organizers, Embryonic / Q000000981:diagnostic imaging / Q000473:pathology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal / Q000706:statistics & numerical data; D055815:Young Adult