[Endotelial activation markers--possibilities of their detection and clinical signification in gynaecology and obstetric].
OBJECTIVE
Summary of the current knowledge of the role of endotelial activation markers in the pathogenesis of the selected diseases and high-risk pregnancy.


METHODS
Review article.


METHODS
Compilation of the published data from scientific literature.


CONCLUSIONS
The endothelium functions in a multitude of physiological processes including the control of cellular trafficking, the regulation of vasomotor tone and maintenance of blood fluidity. Preeclampsia is compared by the the insufficient trofoblastic invasion to the maternal spiral arteries. This changes lead to the insufficiency of the fetoplacental blood flow. The ischaemia of the fetoplacental unit cause the release of specific factors into maternal vessels and subsequent activation of the endothelium and vasoconstriction. We present a short summary of the clinically important endothelial markers and current possibilities of laboratory testing.
Procházková
J
J
Hemato-onkologická klinika FN a LF UP, Olomouc. prochazkovajana@hotmail.com
Pilka
R
R
Mĕchurová
A
A
Simetka
O
O
Brychtová
P
P
Procházka
M
M
D015415:Biomarkers / Q000032:analysis; D004730:Endothelium, Vascular / Q000502:physiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D018180:Thrombomodulin / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D014841:von Willebrand Factor; D010959:Tissue Plasminogen Activator