title: Detection of SNP-SNP interactions in trios of parents with schizophrenic children.
abstract: Schizophrenia (SZ) is a heritable and complex psychiatric disorder with an estimated worldwide prevalence of about 1%. Research on the risk factors for SZ has thus far yielded few clues to causes, but has pointed to a heterogeneous etiology that likely involves multiple genes and gene-environment interactions. In this manuscript, we apply a novel method (trio logic regression, Li et al., 2009) to case-parent trio data from a SZ candidate gene study conducted on families of Ashkenazi Jewish descent, and demonstrate the method's ability to detect multi-gene models for SZ risk in the family-based design. In particular, we demonstrate how this method revealed a genotype-phenotype association that includes an allele without marginal effect.
authors.affiliation: Department of Biostatistics, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: M Daniele
authors.initials: MD
authors.lastname: Fallin
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Louis
authors.forename: Virginia K
authors.initials: VK
authors.lastname: Lasseter
authors.forename: John A
authors.initials: JA
authors.lastname: McGrath
authors.forename: Dimitri
authors.initials: D
authors.lastname: Avramopoulos
authors.forename: Paula S
authors.initials: PS
authors.lastname: Wolyniec
authors.forename: David
authors.initials: D
authors.lastname: Valle
authors.forename: Kung-Yee
authors.initials: KY
authors.lastname: Liang
authors.forename: Ann E
authors.initials: AE
authors.lastname: Pulver
authors.forename: Ingo
authors.initials: I
authors.lastname: Ruczinski
mesh_terms: D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007585:Jews; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D010290:Parents; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*