[Fatality and secular trend of bloodstream infections during hospitalization in China: a systematic review and meta-analysis].
OBJECTIVE
To get an overview of the fatality and secular trend of bloodstream infection (BSI) during hospitalization in China.


METHODS
Papers published between 1990 and Aug. 2008 on the core journals included by Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI) and VIP Chinese Periodical Database were systematically searched. Studies providing data of BSI fatality during hospitalization with a non-comparative, observational design were included. Meta-analysis was done using the generic inverse variance model.


RESULTS
Overall, 72 studies were included for this analysis. The weighted BSI fatality in-hospital based on them was 28.7% (95%CI: 27.2%-30.3%), with substantial differences between study and heterogeneity. For BSI cases from across all departments of hospitals, the weighed fatality was 20.7% (95%CI: 17.8%-24.0%). In the departments of burn, hematology and/or malignant tumors, and ICU, BSI fatalities were even higher, but were relatively low among BSI cases from neonatal wards, and patients with liver diseases, or diabetes mellitus. Fatality of hospital acquired BSI (HA-BSIs, 26.8%, 95%CI: 22.4%-32.0%) was significantly higher than that of community acquired BSI (CA-BSIs). For the past decades, BSI fatality has declined in various kinds of inpatients.


CONCLUSIONS
BSI fatality during hospitalization was at a high level in China, but with a downward trend over the past decades.
Yang
Zu-yao
ZY
Department of Epidemiology and Health Statistics, Peking University School of Public Health, Beijing 100191, China.
Zhan
Si-yan
SY
Wang
Bo
B
Lv
Xiao-zhen
XZ
Shu
Zheng
Z
He
Ying-jian
YJ
Qiu
Ning
N
Yang
Hui-ying
HY
D016470:Bacteremia / Q000401:mortality*; D001424:Bacterial Infections / Q000401:mortality; D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000401:mortality*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D014115:Toxemia / Q000401:mortality*