title: Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.
abstract: A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Waihuan East Road 132, Guangzhou 510080, China.
authors.forename: Zeng-Yun
authors.initials: ZY
authors.lastname: An
authors.forename: Yi-Yong
authors.initials: YY
authors.lastname: Yan
authors.forename: Dan
authors.initials: D
authors.lastname: Peng
authors.forename: Tian-Miao
authors.initials: TM
authors.lastname: Ou
authors.forename: Jia-Heng
authors.initials: JH
authors.lastname: Tan
authors.forename: Shi-Liang
authors.initials: SL
authors.lastname: Huang
authors.forename: Lin-Kun
authors.initials: LK
authors.lastname: An
authors.forename: Lian-Quan
authors.initials: LQ
authors.lastname: Gu
authors.forename: Zhi-Shu
authors.initials: ZS
authors.lastname: Huang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008730:Methoxsalen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D020533:Angiogenesis Inhibitors; D015363:Quinolones; C487585:graveoline; D008730:Methoxsalen