title: The clinico-hematological profile of hairy cell leukaemia: a single centre experience.
abstract: The response rates and overall survival of hairy cell leukemia has changed remarkably with cladribine. Twenty patients diagnosed as hairy cell leukemia over a 5 year period were evaluated. Median age of the patients was 52.5 years. Splenomegaly was seen in 85% and hepatomegaly in 50% patients. At presentation, pancytopenia was seen in 45% and bicytopenia in 20% patients. Tartrate resistant acid phosphatase was positive in 73.68%. Cladribine was given in 13 patients. Overall survival was 84.6%. Median duration of follow-up was 17 months (4-108 months). Direct Coombs' test positive autoimmune hemolytic anemia was seen in two patients (15.38%) on cladribine therapy who required treatment with steroids.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhargava
authors.forename: Rakhee
authors.initials: R
authors.lastname: Kar
authors.forename: Manoranjan
authors.initials: M
authors.lastname: Mahapatra
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017338:Cladribine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine