title: [Electrostimulation for the treatment of dry mouth].
abstract: Xerostomia is a very common condition, which not only involves dry mouth feeling, but can also lead to psychosocial distress, impaired quality of life, and complications, such as dental caries and oral candidiasis. It is generally induced by hypofunction of salivary glands, which has a wide variety of etiologies, such as Sjögren's syndrome, radiotherapy to the head and neck and side effects of medications. Current therapies rely on saliva substitutes and pharmacological stimulation of the parasympathetic system. These treatment modalities are somewhat limited by their short-term efficacy, high cost and drug interactions or other adverse effects. Local transcutaneous or permucosal electrostimulation in areas close to the nerves participating in the salivary autonomic reflex has been found to increase salivary secretion in animal and clinical experiments and to relieve symptoms of dry mouth in patients with salivary gland hypofunction. This concept is reviewed to update the readers on the current status and potential of intraoral miniature electrostimulating devices. They offer promise as an optional safe and non-chemical treatment of xerostomia.
authors.affiliation: Oral Medicine and Special Needs Dentistry Unit, Division of Maxillofacial Diagnostic, Medical and Surgical Sciences, UCL Eastman Dental Institute, London, United Kingdom.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fedele
authors.forename: Andy
authors.initials: A
authors.lastname: Wolff
authors.forename: Frank P
authors.initials: FP
authors.lastname: Strietzel
authors.forename: Rafael
authors.initials: R
authors.lastname: Martín-Granizo López
authors.forename: Stephen
authors.initials: S
authors.lastname: Porter
authors.forename: Yrjö T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D004599:Electric Stimulation Therapy / Q000379:methods*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D012859:Sjogren's Syndrome / Q000150:complications; D013315:Stress, Psychological / Q000209:etiology; D014987:Xerostomia / Q000209:etiology / Q000523:psychology / Q000628:therapy*