Severe cutaneous adverse drug reactions: who should treat, where and how?: Facts and controversies.
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon but extremely serious and often life-threatening mucocutaneous reactions characterized by extensive epithelial sloughing and systemic symptoms. There is no effective evidence-based treatment for severe cutaneous adverse reactions (SCAR) to drugs and no consensus on how to treat these patients. This contribution presents some of the controversies concerning the treatment of SCAR patients, including where and by whom, as well as the issue of the value of treatment with corticosteroids and intravenous immunoglobulin. Investigators agree that more studies are needed and that there are insufficient data to draw definite conclusions. The spectrum of disagreement is wide and the debate is ongoing. At the end, the important question is should we wait with our decisions until all these controversies are settled and we have more or full evidence. This question, as well as all others, is open for debate, evidently a "toxic" debate on toxic epidermal necrolysis.
Wolf
Ronni
R
Dermatology Unit, Kaplan Medical Center, Rechovot 76100, Israel. wolf_r@netvision.net.il
Davidovici
Batya
B
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002053:Burn Units / Q000458:organization & administration*; D003880:Dermatology / Q000458:organization & administration*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D010347:Patient Care Planning; D017410:Practice Guidelines as Topic; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous