title: Echocardiographic screening results in patients with tuberous sclerosis complex.
abstract: We sought to examine the frequency of abnormal echocardiographic findings in patients with tuberous sclerosis complex. In a retrospective cohort study, we included all patients with known tuberous sclerosis complex who had been sent to our cardiology department for echocardiographic screening from 1995 through August 2003 (n=56). Two research scientists independently reviewed the reports of the echocardiographic screening examinations for abnormal findings. We used descriptive statistics, the Mann-Whitney U test, and the chi(2) test. The mean age of patients included in the study was 35 years (range, 12-73 yr); 23 patients were male. Abnormal findings were seen in 22 patients (39%). The most common abnormal findings were focal areas of increased intramyocardial echogenicity, which were seen in 16 patients (29%). The clinical consequence of this finding is still unknown. We conclude that echocardiographic abnormalities are common in patients with tuberous sclerosis complex.
authors.affiliation: Department of Radiology, Atrium Medical Center, 6419 PC Heerlen, The Netherlands. miraude@gmail.com
authors.forename: Miraude E A P M
authors.initials: ME
authors.lastname: Adriaensen
authors.forename: Maarten J M
authors.initials: MJ
authors.lastname: Cramer
authors.forename: Madelon E E
authors.initials: ME
authors.lastname: Brouha
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Schaefer-Prokop
authors.forename: Mathias
authors.initials: M
authors.lastname: Prokop
authors.forename: Pieter A F M
authors.initials: PA
authors.lastname: Doevendans
authors.forename: Bernard A
authors.initials: BA
authors.lastname: Zonnenberg
authors.forename: Harm H H
authors.initials: HH
authors.lastname: Feringa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D002648:Child; D004452:Echocardiography; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014402:Tuberous Sclerosis / Q000150:complications / Q000000981:diagnostic imaging*; D055815:Young Adult