Network analysis of hepatic genes responded to high-fat diet in C57BL/6J mice: nutrigenomics data mining from recent research findings.
Obesity and its associated complications, including diabetes, dyslipidemia, atherosclerosis, and some cancers, have been a global health problem with a rapid increase of the obese population. In this study, we selected 31 obesity candidate genes in the liver of high-fat-induced obese C57BL/6J mice through investigation of literature search and analyzed functional protein-protein interaction of the genes using the STRING database. Most of the obesity candidate genes were closely connected through lipid metabolism, and in particular acyl-coenzyme A oxidase 1 appeared to be a core obesity gene. Overall, genes involved in fatty acid beta-oxidation, fatty acid synthesis, and gluconeogenesis were up-regulated, and genes involved in sterol biosynthesis, insulin signaling, and oxidative stress defense system were down-regulated with a high-fat diet. Future identification of core obesity genes and their functional targets is expected to provide a new way to prevent obesity by phytochemicals or functional foods on the basis of food and nutritional genomics.
Kim
Eun Jung
EJ
Department of Food Science and Nutrition, Food and Nutritional Genomics Research Center, Kyungpook National University, Daegu, Republic of Korea.
Kim
Eunjung
E
Kwon
Eun-Young
EY
Jang
Hyun-Seo
HS
Hur
Cheol-Goo
CG
Choi
Myung-Sook
MS
D000818:Animals; D057225:Data Mining; D030562:Databases, Protein; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D054647:Nutrigenomics; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*
D004041:Dietary Fats