title: [Combined oral contraception and hypercoagulation].
abstract: Combined oral contraceptives have been known as a well-established contraceptive method already more than 50 years. Unfortunately, this method is not absolutely safe. Combined oral contraceptives include estrogens and progestagens, which may stimulate the blood coagulation and promote the occurrence of deep-vein thrombosis; adverse effects of oral contraceptives are also notably associated with increased risk of stroke and myocardial infarction. The risk of hypercoagulation and venous thrombosis is most likely to be influenced by the dose of estrogens, but recent investigations have showed that the type of progestagens is very important as well.
authors.affiliation: Department of Intensive Care, Kaunas University of Medicine, 50009 Kaunas, Lithuania. daliaadu@gmail.com
authors.forename: Dalia
authors.initials: D
authors.lastname: Adukauskiene
authors.forename: Viktorija
authors.initials: V
authors.lastname: Miliauskiene
mesh_terms: D000328:Adult; D000367:Age Factors; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D011372:Progestins / Q000008:administration & dosage / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D019851:Thrombophilia / Q000139:chemically induced*; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D001779:Blood Coagulation Factors; D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D011372:Progestins