[Heritability analysis on serum lipids of adult twins in Qingdao City].
OBJECTIVE
To study the level and heritability of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in adult twins sampled from Qingdao City of China.


METHODS
316 pairs of healthy twin aged 18 to 60 years were recruited from the database of Qingdao City twin registry. Fasting serum lipids were detected by automatic biochemical analyzer. The zygosity of twins was established by using polymorphic DNA-based microsatellite markers. The heritability was estimated by formulating univariate ACE twin mode in Mx soft.


RESULTS
The average levels of fasting serum TC, HDL-C, LDL-C and TG were (4.52 +/- 1.08), (1.46 +/- 0.39), (2.58 +/- 0.79) and (1.11 +/- 0.77) mmol/L, respectively. The best fitting models adjusted by sex and age in Mx soft were AE model for TC, HDL-C and LDL-C, whereas CE model for TG. The heritability of TC, HDL-C, LDL-C and TG were 53% , 62% , 57% and 0, respectively.


CONCLUSIONS
It is considered that both genetic and environmental factors may influence the level of TC, HDL-C and LDL-C, whereas environmental effect may be the factor essential for the level of TG.
Lan
Jinfeng
J
Department of Public Health of Qingdao University Medical College, Qingdao 266021, China. lanjf2009@126.com
Pang
Zengchang
Z
Wang
Shaojie
S
Zhang
Haiping
H
Duan
Haiping
H
Zhang
Dong
D
Tan
Qihua
Q
Zhang
Dongfeng
D
D000293:Adolescent; D000328:Adult; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D040582:Inheritance Patterns; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014427:Twins / Q000235:genetics*; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol