Experimental murine scedosporiosis: histopathology and azole treatment.
The histopathology of clinical isolates of Scedosporium apiospermum, Scedosporium boydii, and Scedosporium aurantiacum in immunosuppressed mice was evaluated. The organs most affected were the brain, kidneys, and spleen. S. aurantiacum produced more tissue damage than the other two species. Amphotericin B (AMB) was ineffective in the treatment of murine infections caused by such isolates, and posaconazole and voriconazole showed efficacy that correlated with the in vitro susceptibility data.
Rodríguez
M Mar
MM
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
Pastor
F Javier
FJ
Salas
Valentina
V
Calvo
Enrique
E
Mayayo
Emilio
E
Guarro
Josep
J
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001393:Azoles / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology; D007668:Kidney / Q000382:microbiology; D051379:Mice; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use; D021681:Scedosporium / Q000187:drug effects* / Q000472:pathogenicity*; D013154:Spleen / Q000382:microbiology; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D001393:Azoles; D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D065819:Voriconazole