title: The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder.
abstract: Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.
authors.affiliation: Institute of Psychiatry, King's College London, MRC SGDP Centre, London, UK. sarah.cohen-woods@kcl.ac.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen-Woods
authors.forename: Ian
authors.initials: I
authors.lastname: Craig
authors.forename: Darya
authors.initials: D
authors.lastname: Gaysina
authors.forename: Joanna
authors.initials: J
authors.lastname: Gray
authors.forename: Cerisse
authors.initials: C
authors.lastname: Gunasinghe
authors.forename: Nick
authors.initials: N
authors.lastname: Craddock
authors.forename: Amanda
authors.initials: A
authors.lastname: Elkin
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones
authors.forename: James
authors.initials: J
authors.lastname: Kennedy
authors.forename: Nicole
authors.initials: N
authors.lastname: King
authors.forename: Ania
authors.initials: A
authors.lastname: Korszun
authors.forename: Jo
authors.initials: J
authors.lastname: Knight
authors.forename: Michael
authors.initials: M
authors.lastname: Owen
authors.forename: Sagar
authors.initials: S
authors.lastname: Parikh
authors.forename: John
authors.initials: J
authors.lastname: Strauss
authors.forename: Abram
authors.initials: A
authors.lastname: Sterne
authors.forename: Federica
authors.initials: F
authors.lastname: Tozzi
authors.forename: Julia
authors.initials: J
authors.lastname: Perry
authors.forename: Pierandrea
authors.initials: P
authors.lastname: Muglia
authors.forename: John
authors.initials: J
authors.lastname: Vincent
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Anne
authors.initials: A
authors.lastname: Farmer
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)