title: Room temperature, copper-catalyzed amination of bromonaphthyridines with aqueous ammonia.
abstract: Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu(2)O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA.
authors.forename: Cyrus A
authors.initials: CA
authors.lastname: Anderson
authors.forename: Phillip G
authors.initials: PG
authors.lastname: Taylor
authors.forename: Mary A
authors.initials: MA
authors.lastname: Zeller
authors.forename: Steven C
authors.initials: SC
authors.lastname: Zimmerman