Microtubes self-assembled from a cholesterol-modified nucleoside.
We describe the formation of lipid microtubes from a novel cholesterol-modified nucleoside in binary mixture with phospholipids. Stable cylindrical structures with an outer diameter of 2-3 microm and a length of 20-40 microm were formed. By varying the preparation conditions, thinner tubules with nanometre-scale diameters could also be obtained.
Pescador
Paula
P
Institute of Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, 04107 Leipzig, Germany. paula.pescador@medizin.uni-leipzig.de
Brodersen
Nicolai
N
Scheidt
Holger A
HA
Loew
Martin
M
Holland
Gudrun
G
Bannert
Norbert
N
Liebscher
Jürgen
J
Herrmann
Andreas
A
Huster
Daniel
D
Arbuzova
Anna
A
D002784:Cholesterol / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry
D009705:Nucleosides; D010743:Phospholipids; D002784:Cholesterol