High performance liquid chromatography enantioseparation of the novel designed mexiletine derivatives and its analogs.
A series of novel designed mexiletine derivatives and its analogs were prepared, the structures were confirmed by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), and Electrospray Ionization-Mass Spectrometry (ESI-MS), and the enantioseparations were performed on polysaccharide-based chiral stationary phase (CSP), Chiralcel OD-H, and Chiralcel OJ-H, under normal-phase mode. The effects of the concentration of isopropanol in the mobile phase were studied, seven of the eight enantiomers got baseline separation on Chiralcel OD-H, and five of the eight enantiomers got successfully separation on Chiralcel OJ-H. The effects of structural features were also discussed.
Zheng
Chengzhen
C
Department of Chemistry, Zhejiang University, Hangzhou, People's Republic of China.
Zhang
Datong
D
Wu
Qi
Q
Lin
Xianfu
X
D019840:2-Propanol / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008801:Mexiletine / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry; D048448:Phenylcarbamates / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry; D013237:Stereoisomerism
D048448:Phenylcarbamates; D011134:Polysaccharides; C065943:cellulose tris-3,5-dimethylphenyl-carbamate; D008801:Mexiletine; D002482:Cellulose; D019840:2-Propanol