title: Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis.
abstract: The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation); p < 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis.
authors.affiliation: Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Doi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Jinju
authors.initials: J
authors.lastname: Nishino
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Akiko
authors.initials: A
authors.lastname: Komiya
authors.forename: Seizo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tokimura
authors.forename: Toshihito
authors.initials: T
authors.lastname: Mori
authors.forename: Keita
authors.initials: K
authors.lastname: Nishimura
authors.forename: Narutaka
authors.initials: N
authors.lastname: Katoh
authors.forename: Jun
authors.initials: J
authors.lastname: Hasegawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Omata
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015210:Arthritis, Gouty / Q000097:blood / Q000175:diagnosis*; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000378:metabolism; D001847:Bone Diseases / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D011237:Predictive Value of Tests; D012372:ROC Curve; D017452:Receptors, IgG / Q000097:blood*
chemical_list: D015415:Biomarkers; D017452:Receptors, IgG