title: Simple synthesis of ruthenium pi complexes of aromatic amino acids and small peptides.
abstract: The interaction of [Ru(eta(6)-C(10)H(8))(Cp)](+) (Cp=C(5)H(5)) with aromatic amino acids (L-phenylalanine, L-tyrosine, L-tryptophane, D-phenylglycine, and L-threo-3-phenylserine) under visible-light irradiation gives the corresponding [Ru(eta(6)-amino acid)(Cp)](+) complexes in near-quantitative yield. The reaction proceeds in air at room temperature in water and tolerates the presence of non-aromatic amino acids (except those which are sulfur containing), monosaccharides, and nucleotides. The complex [Ru(eta(6)-C(10)H(8))(Cp)](+) was also used for selective labeling of Tyr and Phe residues of small peptides, namely, angiotensin I and II derivatives.
authors.affiliation: A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russian Federation.
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Perekalin
authors.forename: Eduard E
authors.initials: EE
authors.lastname: Karslyan
authors.forename: Pavel V
authors.initials: PV
authors.lastname: Petrovskii
authors.forename: Yulia V
authors.initials: YV
authors.lastname: Nelyubina
authors.forename: Konstantin A
authors.initials: KA
authors.lastname: Lyssenko
authors.forename: Alexey S
authors.initials: AS
authors.lastname: Kononikhin
authors.forename: Eugene N
authors.initials: EN
authors.lastname: Nikolaev
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Kudinov
mesh_terms: D024322:Amino Acids, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry*; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D024322:Amino Acids, Aromatic; D009942:Organometallic Compounds; D010455:Peptides; D012428:Ruthenium