Use of nefidipine and acute kidney injury incidence in postoperative of myocardial revascularization surgery with cardiopulmonary bypass.
OBJECTIVE
The objective of this work was to evaluate the influence of the use of nifedipine on the outcome of renal function in patients undergoing myocardial revascularization with extracorporeal circulation.


METHODS
The casuistics and variables related to extracorporeal circulation were studied. Serum creatinine levels were measured preoperatively, 24, 48 hours and on 7th day postoperatively. Renal failure was defined as an increase in 30% of serum creatinine levels at 24 or 48 hours postoperatively compared to those at baseline. Patients were assigned to four groups: G1 (patients who received nifedipine preoperatively); G2 (patients who received nifedipine postoperatively); G3 (patients who received nifedipine pre and postoperatively) and G4 (patients who did not receive nifedipine).


RESULTS
The mean serum creatinine levels postoperatively presented greater rise in G4 (G4>G1=G2=G3), and G4 also presented a higher percentage of patients with acute renal failure (G4>G1 and G4>G3, P<0.05; G1=G3 and G2=G4, P>0.05).


CONCLUSIONS
The evaluation of serum creatinine values and incidence of acute kidney injury postoperatively suggest a possible nefro-potective effect of nifedipine in patients undergoing myocardial revascularization with extracorporeal circulation.
Passaroni
Andréia Cristina
AC
Department of Surgery and Orthopedics - Faculdade de Medicina de Botucatu, UNESP - Universidade Estadual Paulista, Botucatu, SP - Brazil. andreia@fmb.unesp.br
Silva
Marcos Augusto de Moraes
MA
Martins
Antônio Sérgio
AS
Kochi
Ana Cláudia
AC
D058186:Acute Kidney Injury / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D009543:Nifedipine / Q000627:therapeutic use*; D019990:Perioperative Care; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies
D002121:Calcium Channel Blockers; D003404:Creatinine; D009543:Nifedipine