title: Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb.
abstract: In the mouse olfactory system, the anatomical locations of olfactory sensory neurons (OSNs) roughly correlate with their axonal projection sites along the dorsal-ventral (D-V) axis of the olfactory bulb (OB). Here we report that an axon guidance receptor, Neuropilin-2 (Nrp2), and its repulsive ligand, Semaphorin-3F (Sema3F), are expressed by OSNs in a complementary manner that is important for establishing olfactory map topography. Sema3F is secreted by early-arriving axons of OSNs and is deposited at the anterodorsal OB to repel Nrp2-positive axons that arrive later. Sequential arrival of OSN axons as well as the graded and complementary expression of Nrp2 and Sema3F by OSNs help to form the topographic order along the D-V axis.
authors.affiliation: Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Kasumi
authors.initials: K
authors.lastname: Inokuchi
authors.forename: Mari
authors.initials: M
authors.lastname: Aoki
authors.forename: Fumikazu
authors.initials: F
authors.lastname: Suto
authors.forename: Akio
authors.initials: A
authors.lastname: Tsuboi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Matsuda
authors.forename: Misao
authors.initials: M
authors.lastname: Suzuki
authors.forename: Atsu
authors.initials: A
authors.lastname: Aiba
authors.forename: Shou
authors.initials: S
authors.lastname: Serizawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yoshihara
authors.forename: Hajime
authors.initials: H
authors.lastname: Fujisawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sakano
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D015870:Gene Expression; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D039943:Neuropilin-2 / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D049951:X Chromosome Inactivation
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D039943:Neuropilin-2; C492112:Plxna3 protein, mouse; D011956:Receptors, Cell Surface; C491229:Sema3f protein, mouse