title: [Use of recombinant factor VII in Glanzmann thrombasthenia: a case report].
abstract: Glanzmann thrombasthenia (TG) is a congenital platelet function disorder characterized by frequent and occasionally severe bleeding events. Treatment is based on platelet transfusion at the time of bleeding. We report a case of GT revealed in the neonatal period, a severe hemorrhagic syndrome refractory to transfusions, treated at the age of 6 years. Activated recombinant factor VII (Novoseven) injections were necessary. The advantages of recombinant activated factor VII in GT patients with platelet antibodies and/or platelet transfusions refractoriness are discussed.
authors.affiliation: Service pédiatrie, urgences et réanimation pédiatriques, CHU Hédi Chaker, Route El Ain Km 0.5, Sfax, Tunisia. rim.ben-abdallah@laposte.net
authors.forename: R
authors.initials: R
authors.lastname: Chabchoub Ben Abdallah
authors.forename: L
authors.initials: L
authors.lastname: Trabelsi
authors.forename: S
authors.initials: S
authors.lastname: Ben Ameur
authors.forename: F
authors.initials: F
authors.lastname: Kammoun
authors.forename: A
authors.initials: A
authors.lastname: Boukédi
authors.forename: M
authors.initials: M
authors.lastname: Ben Salah
authors.forename: N
authors.initials: N
authors.lastname: Ben Hlima
authors.forename: A
authors.initials: A
authors.lastname: Mahfoudh
mesh_terms: D002648:Child; D015942:Factor VIIa / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D013915:Thrombasthenia / Q000188:drug therapy*
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa