title: No association between oxytocin or prolactin gene variants and childhood-onset mood disorders.
abstract: BACKGROUND
  Oxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. In human studies, serum OXT and PRL levels have been associated with depression and related phenotypes. Our purpose was to determine if single nucleotide polymorphisms (SNPs) at the loci for OXT, PRL and their receptors, OXTR and PRLR, were associated with childhood-onset mood disorders (COMD).
  
  
  METHODS
  Using 678 families in a family-based association design, we genotyped 16 SNPs at OXT, PRL, OXTR and PRLR to test for association with COMD.
  
  
  RESULTS
  No significant associations were found for SNPs in the OXTR, PRL, or PRLR genes. Two of three SNPs 3' of the OXT gene were associated with COMD (p≤0.02), significant after spectral decomposition, but were not significant after additionally correcting for the number of genes tested. Supplementary analyses of parent-of-origin and proband sex effects for OXT SNPs by Fisher's Exact test were not significant after Bonferroni correction.
  
  
  CONCLUSIONS
  We have examined 16 OXT and PRL system gene variants, with no evidence of statistically significant association after correction for multiple tests.
authors.affiliation: Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. john_strauss@camh.net
authors.forename: John S
authors.initials: JS
authors.lastname: Strauss
authors.forename: Natalie L
authors.initials: NL
authors.lastname: Freeman
authors.forename: Sajid A
authors.initials: SA
authors.lastname: Shaikh
authors.forename: Agnes
authors.initials: A
authors.lastname: Vetró
authors.forename: Eniko
authors.initials: E
authors.lastname: Kiss
authors.forename: Krisztina
authors.initials: K
authors.lastname: Kapornai
authors.forename: Gabriella
authors.initials: G
authors.lastname: Daróczi
authors.forename: Timea
authors.initials: T
authors.lastname: Rimay
authors.forename: Viola Osváth
authors.initials: VO
authors.lastname: Kothencné
authors.forename: Edit
authors.initials: E
authors.lastname: Dombovári
authors.forename: Emília
authors.initials: E
authors.lastname: Kaczvinszk
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Tamás
authors.forename: Ildikó
authors.initials: I
authors.lastname: Baji
authors.forename: Márta
authors.initials: M
authors.lastname: Besny
authors.forename: Julia
authors.initials: J
authors.lastname: Gádoros
authors.forename: Vincenzo
authors.initials: V
authors.lastname: DeLuca
authors.forename: Charles J
authors.initials: CJ
authors.lastname: George
authors.forename: Emma
authors.initials: E
authors.lastname: Dempster
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Barr
authors.forename: Maria
authors.initials: M
authors.lastname: Kovacs
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D005190:Family; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics*; D010121:Oxytocin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011388:Prolactin / Q000235:genetics*; D018045:Receptors, Oxytocin / Q000235:genetics; D011981:Receptors, Prolactin / Q000235:genetics
chemical_list: D018045:Receptors, Oxytocin; D011981:Receptors, Prolactin; D010121:Oxytocin; D011388:Prolactin