title: 18F-FDG uptake and calcifications in the thoracic aorta on positron emission tomography/computed tomography examinations: frequency and stability on serial scans.
abstract: OBJECTIVE
  Vascular 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) uptake has been suggested as a means of identifying metabolically active atheroma, whereas vascular calcification is accepted as an indicator of atherosclerosis. This investigation describes the frequency and stability of 18F-FDG uptake and vascular calcification in the thoracic aorta on serial 18F-FDG positron emission tomography/computed tomography (PET/CT) studies and correlates the findings with clinical data and risk factors for cardiovascular disease (CVD).
  
  
  METHODS
  Serial 18F-FDG-PET/CT scans of 100 cancer patients who had at least 2 PET/CT studies were reviewed. Sites of aortic 18F-FDG uptake and calcifications were identified. Results were compared to assess the frequency and stability of the vascular findings and their correlation with clinical data.
  
  
  RESULTS
  18F-FDG aortic uptake was seen in 70% of the patients on the initial scan and changed on the second scan in 55% of the patients. Calcifications were often seen in patients with 18F-FDG uptake, but calcification and 18F-FDG uptake were present at the same site in only 2 cases. Both calcification and 18F-FDG uptake correlated with age. Patients with diabetes, hypertension, hyperlipidemia, or a history of CVD had significantly more calcifications. No correlation was seen between 18F-FDG uptake and calcification stability and the interval between scans, age, risk factors, or history of CVD.
  
  
  CONCLUSIONS
  18F-FDG vascular uptake was common on PET/CT and correlated with vascular calcifications, although the specific sites rarely overlapped. Calcifications were stable over time, but 18F-FDG uptake changed in more than half of the patients, supporting the postulate that inflammation in atheroma is a waxing and waning inflammatory process.
authors.affiliation: Department of Radiology, Federal University of São Paulo, São Paulo, Brazil. gmeirelles@gmail.com
authors.forename: Gustavo Souza Portes
authors.initials: GS
authors.lastname: Meirelles
authors.forename: Mithat
authors.initials: M
authors.lastname: Gonen
authors.forename: Harry William
authors.initials: HW
authors.lastname: Strauss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D004355:Drug Stability; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015588:Observer Variation; D058226:Plaque, Atherosclerotic / Q000175:diagnosis* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012307:Risk Factors; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18