title: [Anesthetic management using remifentanil target controlled infusion without muscle relaxants in two patients with myasthenia gravis].
abstract: Two patients with myasthenia gravis were scheduled for surgery. Anesthesia was managed with remifentanil and propofol target-controlled infusion without the use of muscle relaxants. In both cases, we gradually raised the effect-site concentration of remifentanil and performed tracheal intubation at 10 ng x ml(-1). For both patients, the conditions for tracheal intubation were good, and hemodynamics also stabilized during tracheal intubation. Throughout the surgery, muscle relaxants were not required. Thus, the use of these drugs for inducing anesthesia provided good conditions for tracheal intubation and surgery, and it precluded the need for muscle relaxants.
authors.affiliation: Department of Anesthesia, National Hospital Organization Hokkaido Cancer Center, Sapporo 003-0804.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Abe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kunisawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Sasakawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007262:Infusions, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D009157:Myasthenia Gravis / Q000601:surgery*; D009465:Neuromuscular Agents; D010880:Piperidines / Q000008:administration & dosage*; D010997:Pleural Neoplasms / Q000601:surgery; D015742:Propofol / Q000008:administration & dosage; D000077208:Remifentanil; D013934:Thymectomy
chemical_list: D018686:Anesthetics, Intravenous; D009465:Neuromuscular Agents; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol