FGFs in endochondral skeletal development.
The mammalian skeleton developments and grows through two complementary pathways: membranous ossification, which gives rise to the calvarial bones and distal clavicle, and endochondral ossification, which is responsible for the bones of the limbs, girdles, vertebrae, face and base of the skull and the medial clavicle. Fibroblast growth factors (FGFs) and their cognate FGF receptors (FGFRs) play important roles in regulating both pathways. However, the details of how FGF signals are initiated, propagated and modulated within the developing skeleton are only slowly emerging. This prospect will focus on the current understanding of these events during endochondral skeletal development with special attention given to concepts that have emerged in the past few years.
Degnin
Catherine R
CR
Shriners Hospital and Molecular & Medical Genetics and Cell & Developmental Biology, Oregon Health & Sciences University, Portland, Oregon 97239, USA.
Laederich
Melanie B
MB
Horton
William A
WA
D000818:Animals; D001846:Bone Development / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006132:Growth Plate / Q000254:growth & development / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010012:Osteogenesis / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors