title: Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli.
abstract: Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.
authors.affiliation: School of Molecular Bioscience, University of Sydney, New South Wales, Australia.
authors.forename: Ram
authors.initials: R
authors.lastname: Maharjan
authors.forename: Zhemin
authors.initials: Z
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Joël
authors.initials: J
authors.lastname: Gaffé
authors.forename: Dominique
authors.initials: D
authors.lastname: Schneider
authors.forename: Christopher
authors.initials: C
authors.lastname: McKenzie
authors.forename: Peter R
authors.initials: PR
authors.lastname: Reeves
authors.forename: Thomas
authors.initials: T
authors.lastname: Ferenci
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000222:Adaptation, Physiological; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology*; D035001:Host Factor 1 Protein / Q000235:genetics* / Q000378:metabolism; D009154:Mutation
chemical_list: D029968:Escherichia coli Proteins; C087373:Hfq protein, E coli; D035001:Host Factor 1 Protein; D005947:Glucose