title: Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.
abstract: We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater-than-normal isometric torque drop in dystrophin-deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P < 0.0001). Our findings support the hypothesis that ECCs induce greater-than-normal isometric torque drop in GRMD muscles. The magnitude of ECC-induced isometric torque loss may be an ideal clinical endpoint in the GRMD model.
authors.affiliation: Wake Forest University Health Sciences, Institute for Regenerative Medicine, 391 Technology Way, Winston-Salem, North Carolina 27101, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Tegeler
authors.forename: Robert W
authors.initials: RW
authors.lastname: Grange
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Bogan
authors.forename: Chad D
authors.initials: CD
authors.lastname: Markert
authors.forename: Doug
authors.initials: D
authors.lastname: Case
authors.forename: Joe N
authors.initials: JN
authors.lastname: Kornegay
authors.forename: Martin K
authors.initials: MK
authors.lastname: Childers
mesh_terms: D000818:Animals; D004285:Dogs; D016189:Dystrophin / Q000172:deficiency* / Q000235:genetics*; D004558:Electric Stimulation; D006579:Heterozygote; D007537:Isometric Contraction / Q000235:genetics* / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009137:Muscular Dystrophy, Animal / Q000235:genetics* / Q000503:physiopathology*; D010807:Physical Endurance
chemical_list: D016189:Dystrophin