title: Catalytic SN2'-selective substitution of allylic chlorides with arylboronic esters.
abstract: A copper-catalyzed S(N)2'-selective arylation of allylic chlorides has been achieved using arylboronic esters as nucleophiles. Arylation products were obtained in high yield with a variety of allylic chlorides and arylboronic esters in the presence of a wide range of functional groups. A mechanism is proposed on the basis of the results of stoichiometric experiments and the isolation of the proposed intermediate.
authors.affiliation: Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Whittaker
authors.forename: Richard P
authors.initials: RP
authors.lastname: Rucker
authors.forename: Gojko
authors.initials: G
authors.lastname: Lalic