Ru-catalyzed decarbonylative addition of aliphatic aldehydes to terminal alkynes.
A novel method for the formation of isolated C=C bonds was developed via a ruthenium-catalyzed decarbonylative addition of aliphatic aldehydes and alkynes. An unprecedented complete switch of chemoselectivity from aromatic aldehydes to aliphatic aldehydes was observed simply by using tri(2,4,6-trismethoxyphenyl)phosphine as ligand. A synthesis by this method of an insect sex pheromone was demonstrated.
Guo
Xiangyu
X
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 2K6, Canada.
Wang
Jun
J
Li
Chao-Jun
CJ
D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D012428:Ruthenium / Q000737:chemistry*; D013379:Substrate Specificity
D000447:Aldehydes; D000475:Alkenes; D000480:Alkynes; D012428:Ruthenium