Selective inhibition of proteins regulating CDK/cyclin complexes: strategy against cancer--a review.
Cancer prevention is a global priority, but history indicates that the journey towards achieving the goal is difficult. Various cyclin dependent kinase complexes (CDKs/cyclins) operate as major cell signaling components in all stages of cell cycle. CDK/cyclin protein complexes, regulating the cell cycle, are conserved during evolution. In cancer cells, cell division is uncontrolled and CDKs/cyclins become 'check-points' or targets. Keeping this in view the proteins cyclin C, cyclin D2, CDKN1C, and Growth Arrest and DNA Damage (GADD45alpha) which play a major role in regulating CDK/cyclin complexes and operate in the initial stages of cell cycle (G(0) phase-S phase), have been identified as promising targets. Targeting critical regulators of cell-cycle signaling components by applying modern computational techniques is projected to be a potential tool for future cancer research.
Sarita Rajender
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Department of Chemistry, Nizam College, Basheerbagh, Hyderabad, Andhra Pradesh, India.
Ramasree
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Bhargavi
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Vasavi
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Uma
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D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D000970:Antineoplastic Agents; D016213:Cyclins; D046912:Multiprotein Complexes; D009363:Neoplasm Proteins; D018844:Cyclin-Dependent Kinases