title: Clinical prostate T2 quantification using magnetization-prepared spiral imaging.
abstract: T(2) quantification may augment diagnostic T(2)-weighted imaging; to improve cancer detection via auto-segmentation of multi-parametric acquisitions and to potentiate longitudinal studies of prostate cancer. However, robust quantitative techniques are not generally accessible or refined for clinical translation. This research describes the adaptation of a magnetization-prepared spiral imaging technique, termed T2prep for prostate application, providing whole gland coverage within a 5-min interval with considerable insensitivity to radio-frequency (RF) inhomogeneities. Clinical piloting in two cohorts with distinct clinical histories demonstrated the anticipated differences in zonal and tumor T(2), including tumor T(2) shortening compared to peripheral zone, and post-radiotherapy shortening of peripheral zone T(2). SNR calculations were performed for data acquired with or without an endo-rectal coil in tandem with a torso phased array, to judge the potential for voxel-based T(2) mapping and thereby support focal biological characterization of cancer, hypoxia, and response to therapy within regions of dense cancer burden.
authors.affiliation: Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada. warren.foltz@rmp.uhn.on.ca
authors.forename: Warren D
authors.initials: WD
authors.lastname: Foltz
authors.forename: Supriya
authors.initials: S
authors.lastname: Chopra
authors.forename: Peter
authors.initials: P
authors.lastname: Chung
authors.forename: Andrew
authors.initials: A
authors.lastname: Bayley
authors.forename: Charles
authors.initials: C
authors.lastname: Catton
authors.forename: David
authors.initials: D
authors.lastname: Jaffray
authors.forename: Graham A
authors.initials: GA
authors.lastname: Wright
authors.forename: Masoom A
authors.initials: MA
authors.lastname: Haider
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ménard
mesh_terms: D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008280:Magnetics; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity