Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta.
Three new sulfated sterol dimers, fibrosterol sulfates A-C (1-3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhibited PKCzeta with IC(50) values of 16.4 and 5.6 microM, respectively.
Whitson
Emily L
EL
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Bugni
Tim S
TS
Chockalingam
Priya S
PS
Concepcion
Gisela P
GP
Feng
Xidong
X
Jin
Guixian
G
Harper
Mary Kay
MK
Mangalindan
Gina C
GC
McDonald
Leonard A
LA
Ireland
Chris M
CM
D000818:Animals; D045424:Complex Mixtures / Q000737:chemistry; D019281:Dimerization; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D011161:Porifera / Q000737:chemistry*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry*; D000099221:Protein Kinase C zeta
D045424:Complex Mixtures; D000432:Methanol; D011493:Protein Kinase C; D047428:Protein Kinase Inhibitors; D013261:Sterols; D013431:Sulfates; D000099221:Protein Kinase C zeta