Synthesis and reactivity studies on new copper(II) complexes: DNA binding, generation of phenoxyl radical, SOD and nuclease activities.
Tridentate ligand PhimpH binds to Cu(II) centre after deprotonation affording a new family of complexes [Cu(Phimp)(H(2)O)](2)(ClO(4))(2) (1), [Cu(Phimp)(2)] (2) and [Cu(Phimp)(L)] (3-5) where L are CH(3)COO(-), SCN(-) and NO(2)(-) respectively. The molecular structures of complexes 1 x CH(3)CN and 3 were determined by X-ray crystallography. Electrochemical studies depicted Cu(II)/Cu(I) couple in the range of -0.50 to -0.65 V vs. Ag/AgCl. EPR spectral studies for complexes 4 and 5 indicated the order of covalent character in 4 > 5 with d(x(2)-y(2)) ground state. Novel copper complexes were synthesized by a tridentate ligand having phenolato, pyridine and azomethine nitrogen donors. Phenoxyl radical complexes were generated; DNA interaction, SOD and nuclease activities were investigated. [corrected]
Ghosh
Kaushik
K
Department of Chemistry, Indian Institute of Technology, Roorkee, Roorkee-247667, Uttarakhand, India. ghoshfcy@iitr.ernet.in
Kumar
Pramod
P
Tyagi
Nidhi
N
Singh
Udai P
UP
Aggarwal
Vaibhave
V
Baratto
Maria Camilla
MC
D000042:Absorption; D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004563:Electrochemistry; D008280:Magnetics; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry*; D013057:Spectrum Analysis; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D009942:Organometallic Compounds; D010636:Phenols; C042329:phenoxy radical; D003300:Copper; D004247:DNA; D013482:Superoxide Dismutase; D003851:Deoxyribonucleases