title: N-terminal C-type natriuretic propeptide is associated with the endosteal apposition of bone in females with a persistent eating disorder.
abstract: OBJECTIVE
  Females with anorexia nervosa (AN) are often affected by osteoporosis. The study intends to investigate the association between serum levels of the N-terminal propeptide of the C-type natriuretic peptide (NT-proCNP) and bone development in anorexic females.
  
  
  METHODS
  In a catamnestic visit, 21 females, formerly treated for AN, were assessed for the presence of eating disorders and analyzed for bone parameters of the distal radius (4% site) with peripheral quantitative computed tomography (pQCT), for maximal isometric grip force (MIGF) and for NT-proCNP serum levels.
  
  
  RESULTS
  The 9 females with a persistent eating disorder had lower height and weight than the recovered girls. NT-proCNP was correlated with the cortical area (r = 0.521), the endosteal circumference (CE, r = -0.468) and the ratio of MIGF to cross-sectional bone area (r = 0.434). CE explained 40% of the variance of NT-proCNP in females with persistent eating disorders, but was not associated with NT-proCNP in recovered girls (p = 0.691). The association between CE and NT-proCNP was not existent when the correlation was controlled for the duration of amenorrhea and the supplemented cumulative dose of ethinylestradiol (p = 0.275).
  
  
  CONCLUSIONS
  NT-proCNP reflects metaphyseal inwaisting which is modified by estrogens and the pressure on the growth plate.
authors.affiliation: Children's Hospital, University of Cologne, Germany. frickeo@uni-koeln.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Fricke
authors.forename: Ralf
authors.initials: R
authors.lastname: Beccard
authors.forename: Oliver
authors.initials: O
authors.lastname: Semler
authors.forename: Angelika
authors.initials: A
authors.lastname: Stabrey
authors.forename: Baerbel
authors.initials: B
authors.lastname: Tutlewski
authors.forename: Gerd
authors.initials: G
authors.lastname: Lehmkuhl
authors.forename: Eckhard
authors.initials: E
authors.lastname: Schoenau
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications; D001847:Bone Diseases / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020098:Natriuretic Peptide, C-Type / Q000097:blood*
chemical_list: C480579:amino-terminal pro-C-type natriuretic peptide, human; D020098:Natriuretic Peptide, C-Type