Glycogen synthase kinase-3 and leukemia: restoring the balance.
The role of GSK-3 in oncogenesis is paradoxical, acting as a tumor suppressor in some cancers and potentiating growth in others. In this issue of Cancer Cell, Wang et al. provide some mechanistic insight into GSK-3 activity's role in potentiating leukemias which are dependent on homeobox (HOX) gene misregulation.
Birch
Noah W
NW
Oncology Institute, Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.
Zeleznik-Le
Nancy J
NJ