Abnormal regional homogeneity of drug-naïve obsessive-compulsive patients.
To explore the possible abnormal resting-state activity in patients with obsessive-compulsive disorder (OCD), the regional homogeneity (ReHo) of 22 pairs of patients and well-matched healthy controls was calculated. Compared with controls, the patients showed higher ReHo in the left anterior cingulate cortex, but lower ReHo in the left inferior temporal gyrus. These findings supported the abnormal resting-state brain activity in drug-naïve OCD patients. No significant correlations between ReHo value and four clinical characteristics were found, suggesting that abnormal ReHo might be trait-related in OCD.
Yang
Tao
T
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, Chinese Academy of Sciences, Kunming Institute of Zoology, The First Hospital of Kunming City, Kunming, China.
Cheng
Yuqi
Y
Li
Haijun
H
Jiang
Hongyan
H
Luo
Chunrong
C
Shan
Baoci
B
Xu
Lin
L
Xu
Xiufeng
X
D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000473:pathology*