[Effect of vitamin D deficiency on cardiovascular risk].
Vitamin D deficiency affects almost 50 % of the population worldwide. Besides its classical effects on bone and calcium metabolism, vitamin D displays a wide spectrum of non classical effects. Among these effects, those targeting the cardiovascular system are mostly documented by observational, experimental and small intervention trials that most often evaluated intermediate parameters. The time has now come for large placebo-controlled trials targeting clinical endpoints such as the incidence of major cardiovascular events and mortality.
Cormier
C
C
Service de rhumatologie, hôpital Cochin, AP-HP, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. catherine.cormier@cch.aphp.fr
Courbebaisse
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M
Maury
E
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Thervet
E
E
Souberbielle
J-C
JC
D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D004282:Documentation; D006801:Humans; D015994:Incidence; D018570:Risk Assessment; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology*