title: Comparative examination of androgen receptor reactivity for differential diagnosis of sebaceous carcinoma from squamous cell and basal cell carcinoma.
abstract: Sebaceous carcinoma (SEB) is the most important malignant tumor of the eyelid. Early diagnosis and proper treatment significantly improve the outcome. SEB should be differentiated histopathologically from basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, the expression of androgen receptor (AR) in SEB, SCC, and BCC was evaluated. AR was positive in all 19 SEB cases. Of 18 BCCs, 6 (33%) showed focal nuclear immunoreactivity. The 18 SCCs showed no nuclear immunoreactivity. AR is a sensitive marker for SEB, especially in less differentiated tumors. Along with other markers and morphologic features, AR can be helpful in the diagnosis of SEB and its differentiation from SCC and BCC.
authors.affiliation: Dept of Pathology, Tehran University of Medical Sciences, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Asadi-Amoli
authors.forename: Farid
authors.initials: F
authors.lastname: Khoshnevis
authors.forename: Hayedeh
authors.initials: H
authors.lastname: Haeri
authors.forename: Issa
authors.initials: I
authors.lastname: Jahanzad
authors.forename: Reza
authors.initials: R
authors.lastname: Pazira
authors.forename: Reza
authors.initials: R
authors.lastname: Shahsiah
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000175:diagnosis* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000175:diagnosis* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D011944:Receptors, Androgen