Hemilingual spasm: defining a new entity, its electrophysiological correlates and surgical treatment through microvascular decompression.
OBJECTIVE
We report on vascular compression syndrome of the 12th cranial nerve (hypoglossal), an occurrence not previously reported, and demonstrate, through corresponding objective electrophysiological evidence, that microvascular decompression of the hypoglossal nerve root can cure hemilingual spasm.


METHODS
A 52-year-old man had lower face muscle twitching and tongue spasms, which worsened with talking, chewing, or emotional stress. Carbamazepine offered only temporary relief, and relief from injections of botulinum toxin was insignificant. He was referred for surgical treatment. High-resolution magnetic resonance imaging of his posterior fossa contents revealed no obvious evidence of any compressive vessel along the facial nerve, but a compressive vessel along the hypoglossal nerve was apparent.


METHODS
The presence of preoperative tongue spasms encouraged interoperative monitoring of tongue motor responses. The facial nerve exit zone was explored, but microsurgical inspection of the seventh/eighth cranial nerve complex did not reveal any compressive vessel. However, at the anterolateral aspect of the medulla oblongata, the hypoglossal nerve was clearly compressed and distorted laterally by a large tortuous vertebral artery. When the artery was mobilized away from the nerve, the abnormal late electromyographic response to transcranial electrical stimulation disappeared; immediately after shredded Teflon was interpositioned between the artery and the nerve, the abnormal spontaneous tongue fasciculation also disappeared. The patient has remained spasm free 6 months after surgery.


CONCLUSIONS
Hemilingual spasm may be caused by vascular contact/compression along cranial nerve XII at the lower brainstem and belong to the same family of cranial nerve hyperactivity disorders as hemifacial spasm.
Osburn
Leisha L
LL
Clarian Neuroscience, Department of Neurophysiology, Indianapolis, Indiana 46202, USA.
Møller
Aage R
AR
Bhatt
Jay R
JR
Cohen-Gadol
Aaron A
AA
D002561:Cerebrovascular Disorders / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D019299:Decompression, Surgical / Q000379:methods; D006801:Humans; D020437:Hypoglossal Nerve Diseases / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D013035:Spasm / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D014059:Tongue / Q000294:innervation / Q000503:physiopathology*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods