Combined central precocious puberty and primary gonadal failure after treatment of childhood malignancy in two boys: a diagnostic and therapeutic conundrum.
Central precocious puberty and primary gonadal failure are known sequelae of childhood cancer or its treatment. Here we report two boys with coexistent central precocious puberty and primary gonadal failure after treatment for childhood malignancies.
Nabhan
Zeina M
ZM
Section of Pediatric Endocrinology/Diabetology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. znabhan@iupui.edu
Mieszczak
Jakub
J
Eugster
Erica A
EA
D001254:Astrocytoma / Q000188:drug therapy*; D002648:Child; D006801:Humans; D007006:Hypogonadism / Q000209:etiology*; D007029:Hypothalamic Neoplasms / Q000188:drug therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011629:Puberty, Precocious / Q000209:etiology*