Association of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism with advanced-stage endometriosis.
OBJECTIVE
To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in a Korean population.


METHODS
Case-control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.


RESULTS
The distribution of the PPAR-γ2 Pro12Ala polymorphism was different between the advanced-stage endometriosis group and the control group (non-CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala-12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) (P = 0.006).


CONCLUSIONS
These findings suggest that the PPAR-γ2 Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala-12 allele may have protective effects against advanced-stage endometriosis in the Korean population.
Hwang
Kyu Ri
KR
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
Choi
Young Min
YM
Kim
Jong Mee
JM
Lee
Gyoung Hoon
GH
Kim
Jin Ju
JJ
Chae
Soo Jin
SJ
Moon
Shin Yong
SY
D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004715:Endometriosis / Q000235:genetics* / Q000276:immunology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D047495:PPAR gamma / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
D047495:PPAR gamma; D004247:DNA