Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease.
OBJECTIVE
To test whether colchicine would be an effective antifibrotic agent for treatment of chronic liver diseases in patients who could not be treated with alpha-interferon.


METHODS
Seventy-four patients (46 males, 28 females) aged 40-66 years (mean 53 +/- 13 years) participated in the study. The patients were affected by chronic liver diseases with cirrhosis which was proven histologically (n = 58); by chronic active hepatitis C (n = 4), chronic active hepatitis B (n = 2), and chronic persistent hepatitis C (n = 6). In the four patients lacking histology, cirrhosis was diagnosed from anamnesis, serum laboratory tests, esophageal varices and ascites. Patients were assigned to colchicine (1 mg/d) or standard treatment as control in a randomized, double-blind trial, and followed for 4.4 years with clinical and laboratory evaluation.


RESULTS
Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group (P = 0.001). Serum N-terminal peptide of type III procollagen levels fell from 34.0 to 18.3 ng/mL (P = 0.0001), and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL (P = 0.0001) in the colchicine group, while no significant change was seen in controls. Best results were obtained in patients with chronic hepatitis C and in alcoholic cirrhotics.


CONCLUSIONS
Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fibrosis progresses towards cirrhosis.
Muntoni
Sergio
S
Centre for Metabolic Diseases and Atherosclerosis, The Metabolic Diseases and their Complications Association, Viale Trento 27/A, 09123 Cagliari, Italy. sergiomuntoni@hotmail.com
Rojkind
Marcos
M
Muntoni
Sandro
S
D000328:Adult; D000368:Aged; D002091:Butyrylcholinesterase / Q000378:metabolism*; D003078:Colchicine / Q000627:therapeutic use*; D024061:Collagen Type III / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011347:Procollagen / Q000378:metabolism*
D024061:Collagen Type III; D011347:Procollagen; D002091:Butyrylcholinesterase; D003078:Colchicine