Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits.
We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2.
Oh
Sangtae
S
Department of Basic Science and Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea.
Park
Byong-Gon
BG
Ham
Jungyeob
J
Lee
Seokjoon
S
D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000502:physiology; D008386:Marine Biology; D011817:Rabbits; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D014665:Vasodilator Agents; D000096:Acetone