title: Relationship of serum superoxide dismutase activity and lifestyle in healthy Japanese adults.
abstract: Superoxide dismutase (SOD) is an antioxidant enzyme that acts to degrade superoxide, a major causitive factor for oxidative stress associated with cancer, cardiovascular disease, and various other ailments. Here, to assess an association between antioxidants and lifestyle factors related to cancer risk, we analyzed serum SOD activity among the subjects within a large-scale cohort study in Japan. As results, significant differences in serum SOD activity were found between the sexes (lower in males), among female age groups (lower in younger individuals), and in males with the BMI (lower in those with a high BMI). Linear increase in serum SOD activity with aging and decrease with BMI were observed in females. Significantly low SOD activity was evident in male heavy smokers. In contrast, elevation was noted in female frequent drinkers. In conclusion, our findings do suggest associations between serum SOD activity and lifestyle factors. However, for further study, establishment of a standard measurement method for SOD activity should be a high priority.
authors.affiliation: Department of Public Health, Sapporo Medical University School of Medicine, Japan. nojima@sapmed.ac.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Nojima
authors.forename: Fumio
authors.initials: F
authors.lastname: Sakauchi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
authors.forename: Kei
authors.initials: K
authors.lastname: Nakachi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood*; D000072105:Superoxide Dismutase-1
chemical_list: D015415:Biomarkers; C000606290:SOD1 protein, human; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1