Post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation: a case report.
BACKGROUND
Because the normal ovary is assumed to be devoid of lymphoid tissue, it is unusual for it to be an initial manifestation of malignant lymphoma. This case is the first report, to our knowledge, of post-transplant lymphoproliferative disorder involving the ovary as an initial manifestation.


METHODS
Twenty-nine weeks after a living renal transplantation, a 38-year-old Japanese female, whose ethnic origin was Asian, presented with abdominal pain and a chronic high fever. Computed tomography revealed a right ovarian tumor and liver metastases. The patient underwent oophrectomy based on the clinical diagnosis of liver metastasis from the primary ovarian tumor. The pathological diagnosis was Epstein-Barr Virus-associated post-transplant lymphoproliferative disorder. While ovarian malignant lymphoma has a poor prognosis, complete remission of liver involvement in this case was achieved only with a reduction of immunosuppressants.


CONCLUSIONS
Clinicians should remember that malignant lymphoma could initially involve the ovary, especially if the patient is immunosuppressed after transplantation therapy.
Inoue
Takamitsu
T
Department of Urology, Akita University School of Medicine, Akita 010-8543, Japan. shigerus@doc.med.akita-u.ac.jp.
Satoh
Shigeru
S
Saito
Mitsuru
M
Horikawa
Yohei
Y
Tsuchiya
Norihiko
N
Habuchi
Tomonori
T