title: [Heritability analysis on serum lipids of adult twins in Qingdao City].
abstract: OBJECTIVE
  To study the level and heritability of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in adult twins sampled from Qingdao City of China.
  
  
  METHODS
  316 pairs of healthy twin aged 18 to 60 years were recruited from the database of Qingdao City twin registry. Fasting serum lipids were detected by automatic biochemical analyzer. The zygosity of twins was established by using polymorphic DNA-based microsatellite markers. The heritability was estimated by formulating univariate ACE twin mode in Mx soft.
  
  
  RESULTS
  The average levels of fasting serum TC, HDL-C, LDL-C and TG were (4.52 +/- 1.08), (1.46 +/- 0.39), (2.58 +/- 0.79) and (1.11 +/- 0.77) mmol/L, respectively. The best fitting models adjusted by sex and age in Mx soft were AE model for TC, HDL-C and LDL-C, whereas CE model for TG. The heritability of TC, HDL-C, LDL-C and TG were 53% , 62% , 57% and 0, respectively.
  
  
  CONCLUSIONS
  It is considered that both genetic and environmental factors may influence the level of TC, HDL-C and LDL-C, whereas environmental effect may be the factor essential for the level of TG.
authors.affiliation: Department of Public Health of Qingdao University Medical College, Qingdao 266021, China. lanjf2009@126.com
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Lan
authors.forename: Zengchang
authors.initials: Z
authors.lastname: Pang
authors.forename: Shaojie
authors.initials: S
authors.lastname: Wang
authors.forename: Haiping
authors.initials: H
authors.lastname: Zhang
authors.forename: Haiping
authors.initials: H
authors.lastname: Duan
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Qihua
authors.initials: Q
authors.lastname: Tan
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D040582:Inheritance Patterns; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014427:Twins / Q000235:genetics*; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol