title: Phenylpropionic acid derivates from the bark of Cerbera manghas.
abstract: Two new phenylpropionic acid derivates, cerberic acids A (1) and B (2), were isolated from the bark of Cerbera manghas. Their structures were established on the basis of spectroscopic methods including IR, ESI-FT-ICR-MS, 1D and 2D NMR. Primary bioassays showed that compound 1 possessed weak cytotoxic activity against HepG2, MCF-7, and HeLa cell lines with IC(50) values of 44.7, 52.3, 48.7 μg/ml, respectively.
authors.affiliation: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 57110, China.
authors.forename: Xiao Po
authors.initials: XP
authors.lastname: Zhang
authors.forename: Ming Sheng
authors.initials: MS
authors.lastname: Liu
authors.forename: Yue Hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Jun Qing
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Sheng Li
authors.initials: SL
authors.lastname: Kang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010666:Phenylpropionates; D010936:Plant Extracts; C557328:cerberic acid A; C557329:cerberic acid B