title: [Analysis of the 14 bp insertion/deletion polymorphism in human leukocyte antigen-G gene in Chinese Dai and Han ethnic groups in Yunnan Province].
abstract: A 14 bp insertion/deletion polymorphism (+14 bp/-14 bp) in exon 8 of HLA-G gene has been investigated extensively because this polymorphism was associated with HLA-G mRNA stability and could influence HLA-G mRNA expression. In the present study, we genotyped 14 bp insertion/deletion polymorphisms in the HLA-G gene in Dai and Han populations in Yunnan Province. The frequencies of +14 bp in Dai and Han were 31.97% and 40.87%, respectively. The frequency of +14 bp/+14 bp in Dai was lower (8.20%) than that of Han (17.31%). Nevertheless, the frequency of +14 bp/-14 bp was similar in both populations (47.54% in Dai and 47.11% in Han). When compared with other populations, the frequency of 14 bp insertion/deletion of Han was similar to others, whereas the Dai showed significant difference from others and presented it's specific characteristic. We assumed that the distribution characteristic of 14 bp insertion/deletion in Dai might be the results of random genetic drift, but the role of natural selection cannot be excluded.
authors.affiliation: Department of Medical Genetics, Institute of Medical Biology, Chinese Acadamy of Medical Sciences, Peking Union Medical College, Kunming 650118, China. chenjinbao666@126.com
authors.forename: Jin-Bao
authors.initials: JB
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Yao
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Lin
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Tao
authors.forename: Wen
authors.initials: W
authors.lastname: Yi
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Huang
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Jia-You
authors.initials: JY
authors.lastname: Chu
mesh_terms: D002681:China / Q000208:ethnology; D005091:Exons; D005260:Female; D017353:Gene Deletion; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D016254:Mutagenesis, Insertional; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I