title: [On the mechanisms of formation of the serum structural macroportrait in subjects suffering fatal intoxication with narcotic and potent substances].
abstract: Intoxication with narcotic and potent substances was shown to lead to the development of specific features in the serum structural macroportrait. Peculiarities of profiles of low and high molecular weight substances and acoustic-mechanical impedance parameters in blood serum were identified in subjects with drug poisoning. It is demonstrated that streaking pattern in the central zone of a dehydrated serum droplet described in an earlier study of subjects suffering intoxication with narcotic and potent substances result from structural decomposition of immunoglobulins under effect of oxidative modification. The proposed technologies provide a basis for the development of a method for rapid determination of the presence or absence of intoxication with narcotic and potent substances.
authors.forename: N S
authors.initials: NS
authors.lastname: Edelev
authors.forename: L M
authors.initials: LM
authors.lastname: Obukhova
authors.forename: A S
authors.initials: AS
authors.lastname: Konov
mesh_terms: D000435:Alcoholic Intoxication / Q000097:blood*; D062787:Drug Overdose; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood*; D005260:Female; D005554:Forensic Medicine / Q000379:methods*; D006801:Humans; D008297:Male; D009294:Narcotics / Q000097:blood* / Q000633:toxicity*; D044967:Serum
chemical_list: D009294:Narcotics; D000431:Ethanol