title: Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents.
abstract: The anti-diarrhoeal effect of aqueous extract of Rubia tinctorum L. (Rubiaceae) roots in rodents was examined. At doses 300, 600 and 800 mg/kg aqueous extract protected rats, in a dose-dependent fashion, against castor oil-induced diarrhoeal dropping by 37, 59 and 64% respectively. Furthermore, it has significantly inhibited by 41% the gastrointestinal transit of charcoal in mice at 800 mg/kg dose of extract. These data suggest that Rubia tinctorum showed antidiarrhoeal activity by inhibiting intestinal motility which was concordant with its use in traditional medicine.
authors.affiliation: Laboratoire de Physiologie et Ethnopharmacologie, Macromoléculaire et Produits Naturels, Université Mohammed 1er, Faculté des Sciences.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Karim
authors.forename: Hassane
authors.initials: H
authors.lastname: Mekhfi
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Ziyyat
authors.forename: Abdelkhaleq
authors.initials: A
authors.lastname: Legssyer
authors.forename: Mohammed
authors.initials: M
authors.lastname: Bnouham
authors.forename: Souliman
authors.initials: S
authors.lastname: Amrani
authors.forename: Fouad
authors.initials: F
authors.lastname: Atmani
authors.forename: Ahmed
authors.initials: A
authors.lastname: Melhaoui
authors.forename: Mohammed
authors.initials: M
authors.lastname: Aziz
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D002368:Castor Oil / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D045424:Complex Mixtures / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects; D008139:Loperamide / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012377:Rodentia; D045470:Rubia / Q000737:chemistry; D019666:Rubiaceae / Q000187:drug effects; D014867:Water / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000930:Antidiarrheals; D045424:Complex Mixtures; D014867:Water; D008139:Loperamide; D002368:Castor Oil