title: Does betahistine treatment have additional benefits to vestibular rehabilitation?
abstract: The aim of this study was to investigate the effect of high-dose betahistine treatment added to vestibular rehabilitation (VR) on the disability, balance and postural stability in patients with unilateral vestibular disorder. The VR group (group 1, n = 24) and the VR + betahistine group (group 2, n = 23) were analyzed retrospectively. All patients were evaluated before and after an 8-week customized VR in terms of disability (Dizziness Handicap Inventory, DHI), dynamic balance [Dynamic Gait Index (DGI)] and postural stability (static posturography). In group 1 and group 2, differences between DHI, DGI and falling index score on static posturography before and after the exercise program were significant (p < 0.05). In addition, a significant difference was detected only in group 2 in the variables evaluated in static posturography-Fourier 4 analysis (p < 0.05). Both VR and betahistine + VR have a positive effect on disability and balance in patients with unilateral vestibular disorder. Betahistine treatment added to VR was effective in increasing postural stability.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ege University, 35100 Bornova, Izmir, Turkey. haleuzum76@hotmail.com
authors.forename: Hale
authors.initials: H
authors.lastname: Karapolat
authors.forename: Nese
authors.initials: N
authors.lastname: Celebisoy
authors.forename: Yesim
authors.initials: Y
authors.lastname: Kirazli
authors.forename: Cem
authors.initials: C
authors.lastname: Bilgen
authors.forename: Sibel
authors.initials: S
authors.lastname: Eyigor
authors.forename: Sercan
authors.initials: S
authors.lastname: Gode
authors.forename: Aycan
authors.initials: A
authors.lastname: Akyuz
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kirazli
mesh_terms: D000328:Adult; D000368:Aged; D001621:Betahistine / Q000008:administration & dosage*; D002150:Caloric Tests; D003131:Combined Modality Therapy; D004185:Disability Evaluation; D004305:Dose-Response Relationship, Drug; D005081:Exercise Therapy; D005260:Female; D005684:Gait; D017442:Histamine Agonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000534:rehabilitation*; D008875:Middle Aged; D004856:Postural Balance / Q000187:drug effects; D012189:Retrospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D017442:Histamine Agonists; D014665:Vasodilator Agents; D001621:Betahistine