Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.
We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater-than-normal isometric torque drop in dystrophin-deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P < 0.0001). Our findings support the hypothesis that ECCs induce greater-than-normal isometric torque drop in GRMD muscles. The magnitude of ECC-induced isometric torque loss may be an ideal clinical endpoint in the GRMD model.
Tegeler
Christopher J
CJ
Wake Forest University Health Sciences, Institute for Regenerative Medicine, 391 Technology Way, Winston-Salem, North Carolina 27101, USA.
Grange
Robert W
RW
Bogan
Daniel J
DJ
Markert
Chad D
CD
Case
Doug
D
Kornegay
Joe N
JN
Childers
Martin K
MK
D000818:Animals; D004285:Dogs; D016189:Dystrophin / Q000172:deficiency* / Q000235:genetics*; D004558:Electric Stimulation; D006579:Heterozygote; D007537:Isometric Contraction / Q000235:genetics* / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009137:Muscular Dystrophy, Animal / Q000235:genetics* / Q000503:physiopathology*; D010807:Physical Endurance
D016189:Dystrophin