title: Physicochemical characteristics and in vitro release from oil-based vehicles of peptidomimetics: parenteral depots for intra-articular administration.
abstract: RESULTS
  Basic physicochemical properties including their apparent solubility in aqueous buffer and vegetable oils of a series of 11 peptidomimetics varying with respect to chain length and degree of N-methylation were estimated. It was observed that the compounds in contact with water transformed into sticky, slowly dissolving semisolid materials. Based on these observations, the in vitro release behavior of selected peptide derivatives from oil solutions and in situ formed precipitates was investigated using a validated in vitro release model.
  
  
  CONCLUSIONS
  The results of this investigation suggest that both types of oil-based drug delivery systems might constitute alternative sustained release formulation principles of such amorphous peptide derivatives for the intra-articular route of administration.
authors.affiliation: Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Brian Thoning
authors.initials: BT
authors.lastname: Pedersen
authors.forename: Jesper
authors.initials: J
authors.lastname: Ostergaard
authors.forename: Susan Weng
authors.initials: SW
authors.lastname: Larsen
authors.forename: Claus
authors.initials: C
authors.lastname: Cornett
authors.forename: Michael
authors.initials: M
authors.lastname: Ankersen
authors.forename: Claus
authors.initials: C
authors.lastname: Larsen
mesh_terms: D000595:Amino Acid Sequence; D001702:Biopharmaceutics; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D007270:Injections, Intra-Articular; D008969:Molecular Sequence Data; D009821:Oils / Q000737:chemistry*; D057786:Peptidomimetics / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D009821:Oils; D057786:Peptidomimetics; D014677:Pharmaceutical Vehicles; D010938:Plant Oils; D014867:Water