title: Sleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance.
abstract: Sleep-disordered breathing is associated with obesity, insulin resistance, and the metabolic syndrome in adults. Similar data in children is limited and conflicting. This pilot study examined the relationships between sleep-disordered breathing, visceral adiposity, and cardiometabolic risk factors in obese adolescents. Twenty obese (body mass index ≥ 95(th) percentile), otherwise healthy adolescents (age 14.9 ± 2 years) underwent polysomnogram studies, fasting lipid profile and oral glucose tolerance tests, and measures of body composition (dual-energy X-ray absorptiometry) and visceral adiposity (abdominal computed tomography). The severity of sleep-disordered breathing (as measured by apnea-hypopnea index) was positively associated with visceral adipose tissue (r = 0.73, p < 0.001) but not with other measures of body composition. After controlling for body mass index, the severity of sleep-disordered breathing was positively associated with markers of insulin resistance (homeostasis model assessment and fasting insulin). Further study to allow for critical assessment of the relationships between sleep-disordered breathing and cardiometabolic risk factors in obese youth remains necessary.
authors.affiliation: Division of Weight Management and Wellness, Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. tamara.hannon@chp.edu
authors.forename: Tamara S
authors.initials: TS
authors.lastname: Hannon
authors.forename: Sojung
authors.initials: S
authors.lastname: Lee
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Chakravorty
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Silva A
authors.initials: SA
authors.lastname: Arslanian
mesh_terms: D050154:Adiposity; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000378:metabolism*; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000378:metabolism