Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, which covers a worldwide geographic area. Demographic and lifestyle characteristics were examined in relation to 25(OH)D using stepwise linear regression and polytomous logistic regression. The prevalence of 25(OH)D concentrations less than 25 nmol/L ranged from 3% to 36% across cohorts, and the prevalence of 25(OH)D concentrations less than 50 nmol/L ranged from 29% to 82%. Seasonal differences in circulating 25(OH)D were most marked among whites from northern latitudes. Statistically significant positive correlates of 25(OH)D included male sex, summer blood draw, vigorous physical activity, vitamin D intake, fish intake, multivitamin use, and calcium supplement use. Significant inverse correlates were body mass index, winter and spring blood draw, history of diabetes, sedentary behavior, smoking, and black race/ethnicity. Correlates varied somewhat within season, race/ethnicity, and sex. These findings help identify persons at risk for low vitamin D status for both clinical and research purposes.
McCullough
Marjorie L
ML
American Cancer Society, Atlanta, Georgia 30303-1002, USA. marji.mccullough@cancer.org
Weinstein
Stephanie J
SJ
Freedman
D Michal
DM
Helzlsouer
Kathy
K
Flanders
W Dana
WD
Koenig
Karen
K
Kolonel
Laurence
L
Laden
Francine
F
Le Marchand
Loic
L
Purdue
Mark
M
Snyder
Kirk
K
Stevens
Victoria L
VL
Stolzenberg-Solomon
Rachael
R
Virtamo
Jarmo
J
Yang
Gong
G
Yu
Kai
K
Zheng
Wei
W
Albanes
Demetrius
D
Ashby
Jason
J
Bertrand
Kimberly
K
Cai
Hui
H
Chen
Yu
Y
Gallicchio
Lisa
L
Giovannucci
Edward
E
Jacobs
Eric J
EJ
Hankinson
Susan E
SE
Hartge
Patricia
P
Hartmuller
Virginia
V
Harvey
Chinonye
C
Hayes
Richard B
RB
Horst
Ronald L
RL
Shu
Xiao-Ou
XO
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D008297:Male; D009369:Neoplasms / Q000208:ethnology / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D011446:Prospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology* / Q000208:ethnology / Q000517:prevention & control
D014807:Vitamin D