title: Severe Eosinophilia in an infant with congenital acute myeloid leukemia with t(3;4;6)(q26;q25;q21): a case report.
abstract: We report a case of acute myeloid leukemia with morphologic features of M7 according to the FAB (French-American-British) classification and severe eosinophilia in the peripheral blood and bone marrow at diagnosis. We consider it as congenital leukemia, as the symptoms started in the first month of life of the affected child. This case of leukemia is characterized by t(3;4;6)(q26;q25;q21) cytogenetic abnormality. The blasts in flow cytometry analysis expressed markers of megakaryocytic lineage along with expression of myeloperoxidase in 30% of them. This type of acute myelogenous leukemia with severe eosinophilia can be considered as a distinct clinicopathologic entity.
authors.affiliation: Hematology Laboratory, P &A Kyriakou Children's Hospital, Thivon and Levadias, Athens, Greece.
authors.forename: Marieta
authors.initials: M
authors.lastname: Harisi
authors.forename: Varvara
authors.initials: V
authors.lastname: Douna
authors.forename: Margarita
authors.initials: M
authors.lastname: Baka
authors.forename: Marina
authors.initials: M
authors.lastname: Servitzoglou
authors.forename: Helen
authors.initials: H
authors.lastname: Kosmidi
authors.forename: Theodora
authors.initials: T
authors.lastname: Anastasiou
mesh_terms: D002469:Cell Separation; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004802:Eosinophilia / Q000235:genetics*; D005158:Facial Paralysis / Q000209:etiology; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000151:congenital* / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic