title: Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
abstract: Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Cummins
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: John
authors.initials: J
authors.lastname: McGinty
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bren
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Bosch
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Martin
authors.forename: Daniel
authors.initials: D
authors.lastname: Douek
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lederman
authors.forename: Jason
authors.initials: J
authors.lastname: Brenchley
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Badley
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry* / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D053181:Caspase 8 / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: C505530:CASP8 protein, human; D053181:Caspase 8