title: Intraocular pressure and related systemic and ocular biometric factors in a population-based study in Japan: the Kumejima study.
abstract: OBJECTIVE
  To examine the distribution of intraocular pressure (IOP) and its related systemic and ocular biometric factors in a population-based study in a southwestern island of Japan.
  
  
  METHODS
  Cross-sectional, population-based study.
  
  
  METHODS
  All residents of Kumejima Island, Japan, located in southwestern Japan (eastern longitude, 126 degrees 48 minutes and northern latitude 26 degrees 20 minutes), 40 years of age and older were asked to undergo a comprehensive questionnaire and ocular examination, including measurement of IOP with Goldmann applanation tonometry.
  
  
  RESULTS
  Of the 4632 eligible residents, 3762 (81.2%) underwent the examination. In 2838 non-glaucomatous subjects from whom reliable measurements of IOP were obtained, the mean IOPs +/- standard deviation in all, men, and women were 15.1 +/- 3.1 mm Hg (n = 2838), 15.2 +/- 3.1 mm Hg (n = 1450), and 15.1 +/- 3.0 mm Hg (n = 1388), respectively, with no significant intersex difference (P = .63). Multivariate regression analysis demonstrated that higher IOP was significantly correlated with younger age (P < .001), higher body mass index (P < .001), higher systolic blood pressure (P < .001), history of diabetes mellitus (P = .001), thicker central corneal thickness (P < .001), steeper corneal curvature (P < .001), and longer axial length (P < .018), but not with anterior chamber depth and the Shaffer angle width grade.
  
  
  CONCLUSIONS
  Younger age, higher body mass index, higher systolic blood pressure, diabetes, thicker central corneal thickness, and steeper corneal curvature were significantly correlated with higher IOP. The present results confirm that IOP is associated with systemic and ocular biometric factors and may define specific subgroups most likely to have an elevated IOP.
authors.affiliation: Department of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Tomoyose
authors.forename: Akiko
authors.initials: A
authors.lastname: Higa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakai
authors.forename: Shoichi
authors.initials: S
authors.lastname: Sawaguchi
authors.forename: Aiko
authors.initials: A
authors.lastname: Iwase
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tomidokoro
authors.forename: Shiro
authors.initials: S
authors.lastname: Amano
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001699:Biometry; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D016021:Epidemiologic Studies; D005260:Female; D005901:Glaucoma / Q000453:epidemiology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012016:Reference Values; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014065:Tonometry, Ocular