title: ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players.
abstract: We examined the association of R577X polymorphism (rs1815739) in the α-actinin-3 (ACTN3) gene with "explosive" leg muscle power performance in a group of male and female elite volleyball players (n=66, 31 men, 35 women) and in a group of non-athletic male and female young adults (n=334, 243 men, 91 women). We assessed power performance by means of the vertical squat and counter-movement jump tests. We also determined whether the genotypic frequencies of the ACTN3 R577X genotypes differed between groups. We did not observe any effect of the ACTN3 R577X polymorphism on study phenotypes in both groups, regardless of gender (all P>0.05). Genotype frequencies were similar between volleyball and control groups (P=0.095). Moreover, we did not find an association between the ACTN3 R577X polymorphism and the likelihood of being an elite volleyball player using the dominant (RR vs RX+XX) and the recessive model (RR+RX vs XX). In summary, these findings suggest that the ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players.
authors.affiliation: Department of Biosciences and Nutrition, Unit for Preventive Nutrition, Karolinska Institutet, Stockholm, Sweden. ruizj@ugr.es
authors.forename: J R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Fernández del Valle
authors.forename: Z
authors.initials: Z
authors.lastname: Verde
authors.forename: I
authors.initials: I
authors.lastname: Díez-Vega
authors.forename: C
authors.initials: C
authors.lastname: Santiago
authors.forename: T
authors.initials: T
authors.lastname: Yvert
authors.forename: G
authors.initials: G
authors.lastname: Rodríguez-Romo
authors.forename: F
authors.initials: F
authors.lastname: Gómez-Gallego
authors.forename: J J
authors.initials: JJ
authors.lastname: Molina
authors.forename: A
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000185:Actinin / Q000235:genetics*; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology*; D005260:Female; D006801:Humans; D007866:Leg / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000235:genetics* / Q000502:physiology; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism; D053580:Muscle Strength / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D013030:Spain; D054798:Volleyball / Q000502:physiology*; D055815:Young Adult
chemical_list: C118456:ACTN3 protein, human; D000185:Actinin