Minor constituents from the tubers of Gymnadenia conopsea.
Four new minor constituents including two cyclodipeptides (1 and 2) and two cyclopentene derivatives (3 and 4), together with four known cyclodipeptides, have been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Their structures including absolute configurations were determined by spectroscopic data interpretation combined with chemical methods. Among them, compound 1 contains an abnormal S-(4''-hydroxybenzyl)cysteine residue, 3 and 4 possess [(4-methylcyclopentyl)methyl]benzene and (4-hydroxymethylcyclopentyl)benzene carbon skeletons, respectively, both of which are first found from the natural source.
Zi
Jia-Chen
JC
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lin
Sheng
S
Zhu
Cheng-Gen
CG
Yang
Yong-Chun
YC
Shi
Jian-Gong
JG
D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D035281:Plant Tubers / Q000737:chemistry
D003517:Cyclopentanes; D004365:Drugs, Chinese Herbal; D010456:Peptides, Cyclic