title: Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm. f.
abstract: The antitermite (termiticidal and antifeedant) activity of Protium javanicum Burm. f. extract was investigated. The ethyl acetate fraction was active. Scopoletin (1), quercetin, and stigmasterol were isolated by bioassay-guided fractionation. Scopoletin had the highest activity among the three compounds. In order to investigate the structure-activity relationship (SAR) of the methoxy and hydroxy groups at the C-6 and C-7 positions of the coumarin skeleton, we synthesized several coumarin derivatives whose chemical structures are similar to scopoletin. Scopoletin exhibited the strongest termiticidal activity among the 10 compounds tested, followed by 6-methoxycoumarin (3), 6-hydroxycoumarin (7), and umbelliferone (8). All compounds except coumarin (9) showed antifeedant activity.
authors.affiliation: Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
authors.forename: Morina
authors.initials: M
authors.lastname: Adfa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Komura
authors.forename: Mamoru
authors.initials: M
authors.lastname: Koketsu
mesh_terms: D000818:Animals; D029403:Burseraceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification; D020049:Isoptera; D010936:Plant Extracts / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification; D012603:Scopoletin / Q000737:chemistry / Q000302:isolation & purification; D013265:Stigmasterol / Q000737:chemistry / Q000302:isolation & purification; D013329:Structure-Activity Relationship; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D003374:Coumarins; D007306:Insecticides; D010936:Plant Extracts; D014468:Umbelliferones; C031477:7-hydroxycoumarin; D013265:Stigmasterol; D011794:Quercetin; C030123:coumarin; D012603:Scopoletin