Integrins and signal transduction.
Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.
Cabodi
Sara
S
Molecular and Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Torino, Italy.
Di Stefano
Paola
P
Leal
Maria del Pilar Camacho
Mdel P
Tinnirello
Agata
A
Bisaro
Brigitte
B
Morello
Virginia
V
Damiano
Laura
L
Aramu
Simona
S
Repetto
Daniele
D
Tornillo
Giusy
G
Defilippi
Paola
P
D000199:Actins / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000378:metabolism
D000199:Actins; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D018121:Receptors, Cytokine; D051416:Focal Adhesion Protein-Tyrosine Kinases; D019061:src-Family Kinases