title: Killing the killer: natural killer cells to treat Ewing's sarcoma.
abstract: Cho and coworkers show that Ewing's sarcoma cells are highly sensitive to expanded allogeneic natural killer (NK) cells, partially through a NKG2D- and DNAM-1-dependent mechanism. Using an orthotopic murine model, they also show that irradiation significantly enhances the NK-cell killing of these tumors.
authors.affiliation: Hematology, Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Yong-Oon
authors.initials: YO
authors.lastname: Ahn
authors.forename: Brenda
authors.initials: B
authors.lastname: Weigel
authors.forename: Michael R
authors.initials: MR
authors.lastname: Verneris
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D012512:Sarcoma, Ewing / Q000628:therapy*