title: The effect of CO2 pneumoperitoneum on serum prostate-specific antigen levels in patients undergoing laparoscopic cholecystectomy.
abstract: BACKGROUND
  Recently, several studies have shown an elevation of serum prostate-specific antigen (PSA) levels after the events associated with presumed pelvic ischemia. Although it has been shown that CO2 pneumoperitoneum during laparoscopic surgery causes splanchnic ischemia, no study has investigated the PSA levels after this procedure. This study aimed to evaluate the effects of CO2 pneumoperitoneum on serum total PSA (tPSA) and free PSA (fPSA) levels in patients undergoing laparoscopic cholecystectomy.
  
  
  METHODS
  This study involved 30 men who underwent elective laparoscopic cholecystectomy. Serum tPSA and fPSA levels and f/tPSA ratios were determined the day before surgery (baseline), immediately before insufflation, after desufflation, and 24 hours and 7 days after surgery.
  
  
  RESULTS
  Serum tPSA and fPSA values after desufflation and 24 hours after surgery were significantly higher than the values before insufflation and at baseline (P<0.01), whereas the f/tPSA ratio did not change (P>0.05). PSA levels decreased to baseline levels after 7 days.
  
  
  CONCLUSIONS
  Our study showed that CO2 pneumoperitoneum during laparoscopic surgery can cause a rise in serum tPSA and fPSA levels. We think that CO2 pneumoperitoneum during laparoscopic surgery should be added to list of the events in which PSA measurements must be interpreted with caution.
authors.affiliation: Department of General Surgery, University of Mersin School of Medicine, Mersin, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Turkmenoglu
authors.forename: Murat
authors.initials: M
authors.lastname: Bozlu
authors.forename: Levent
authors.initials: L
authors.lastname: Isikay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dag
authors.forename: Ozan
authors.initials: O
authors.lastname: Efesoy
authors.forename: Necati
authors.initials: N
authors.lastname: Muslu
authors.forename: Suha
authors.initials: S
authors.lastname: Aydin
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D017081:Cholecystectomy, Laparoscopic; D015331:Cohort Studies; D005705:Gallbladder Diseases / Q000097:blood* / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects; D011184:Postoperative Period; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D017430:Prostate-Specific Antigen