title: Pleural dissemination of esophageal gastrointestinal stromal tumors after an eight-year interval following the primary surgery.
abstract: A 71-year-old man who had undergone surgical resection of esophageal gastrointestinal stromal tumors (GISTs) through a right posterolateral thoracotomy 8 years earlier was referred for treatment of an anterior mediastinal mass discovered on a follow-up chest radiograph in October 2007. Computed tomography findings revealed a tumor, 82 x 49 mm, with calcification, in the anterior mediastinum. When we radically resected the tumor via a median sternectomy, we found that it was actually located in the pleural cavity, and there was a small nodule near the main tumor on other pleura. Microscopically, the tumor was comprised of uniform spindle cells with fibrillary eosinophilic cytoplasm. In addition, immunostaining showed that the tumor was positive for CD117 (c-kit). The diagnosis was pleural dissemination of esophageal GISTs 8 years after primary surgery, making this the first report of pleural dissemination of esophageal GISTs after such a prolonged postsurgical interval.
authors.affiliation: Department of Surgery, Akita University School of Medicine, Akita, 010-8543, Japan. karo@doc.med.akita-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Imai
authors.forename: Hajime
authors.initials: H
authors.lastname: Saito
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Minamiya
authors.forename: Taku
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Ito
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hosono
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D013908:Thoracotomy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome