title: Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.
abstract: An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Goodell
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: McMullen
authors.forename: Nikolay
authors.initials: N
authors.lastname: Zaborenko
authors.forename: Jason R
authors.initials: JR
authors.lastname: Maloney
authors.forename: Chuan-Xing
authors.initials: CX
authors.lastname: Ho
authors.forename: Klavs F
authors.initials: KF
authors.lastname: Jensen
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
mesh_terms: D001331:Automation; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D004867:Equipment Design; D007202:Indicators and Reagents / Q000737:chemistry; D007700:Kinetics; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D012997:Solvents / Q000737:chemistry; D013696:Temperature
chemical_list: D001643:Bridged Bicyclo Compounds; D007202:Indicators and Reagents; D012997:Solvents