title: Elasticity/distensibility of the ascending aorta: basal conditions and simulated conditions from space flights.
abstract: BACKGROUND
  The hysto-morfological composition of the ascending aorta wall gives to the vessel its characteristic elasticity/distensibility, which is deteriorated due to both physiological (age) and pathological events (hypertension, diabetes, dyslipidemia). This contributes to reduce the wall elasticity and to occurrence of cardiovascular events.
  
  
  METHODS
  Thirty young healthy subjects (20 males, 10 females, age <30 yr), were subjected to different postural conditions with and without Lower Body Negative Pressure (LBNP) with conventional procedures, to simulate the microgravity conditions in space flight. During this procedure the cardiovascular parameters and the aorta elasticity were assessed with ecocardiography.
  
  
  RESULTS
  The observation of results and statistical comparison showed that despite different hemodynamic conditions and with significant variation of blood pressure related to posture, elasticity/distensibility did not change significantly.
  
  
  CONCLUSIONS
  The elasticity/distensibility of arterial vessels is the result of two interdependent variables such as blood pressure and systolic and diastolic diameters. While blood pressure and heart rate vary physiologically in relation to posture, the compensation of the vessel diameters modifications maintains the aortic compliance invariate. Therefore, in young healthy people, despite the significant postural and the sudden pressure changes (equivalent to parietal stress) aortic compliance does not alter. This behavior might be related to the low rate of cardiovascular events that are present in healthy people aged under 30 yrs.
authors.affiliation: Department of Cuore e Grossi Vasi "A. Reale", polo pontino, University "Sapienza", Rome, Italy. nicola.alessandri@uniroma1.it
authors.forename: N
authors.initials: N
authors.lastname: Alessandri
authors.forename: F
authors.initials: F
authors.lastname: Tufano
authors.forename: M
authors.initials: M
authors.lastname: Petrassi
authors.forename: C
authors.initials: C
authors.lastname: Alessandri
authors.forename: L
authors.initials: L
authors.lastname: Lanzi
authors.forename: L
authors.initials: L
authors.lastname: Fusco
authors.forename: F
authors.initials: F
authors.lastname: Moscariello
authors.forename: C
authors.initials: C
authors.lastname: De Angelis
authors.forename: E
authors.initials: E
authors.lastname: Tomao
mesh_terms: D000328:Adult; D001011:Aorta / Q000378:metabolism*; D001794:Blood Pressure; D018618:Echocardiography, Doppler, Color / Q000379:methods; D004548:Elasticity; D005260:Female; D006339:Heart Rate; D006801:Humans; D008150:Lower Body Negative Pressure / Q000379:methods*; D008297:Male; D011187:Posture; D013026:Space Flight; D018474:Weightlessness Simulation; D055815:Young Adult