title: 1.5:1 meshed AlloDerm bolsters for stapled rectal anastomoses does not provide any advantage in anastomotic strength in a porcine model.
abstract: BACKGROUND
  The most feared complication of colorectal anastomoses is leaks resulting in severe morbidity. The concept of staple-line reinforcement is a growing area of interest. In this study, the authors evaluated the feasibility and effect of using 1.5:1 meshed AlloDerm to bolster end-to-end stapled rectal anastomoses in a porcine model.
  
  
  METHODS
  A total of 30 female 45-kg domestic pigs were studied, and each served as its own control by creating a bolstered and unbolstered anastomosis in each animal. All anastomoses were created with a 29-mm end-to-end stapling device. Bolstered anastomoses were randomized to proximal and distal positions along the rectum, and each rectorectal anastomosis was separated by an average of 10 cm. The animals were survived to 3, 5, and 30 days. Barium enemas were then performed and the 2 anastomotic sites harvested. Each anastomosis underwent burst testing. The internal diameter of each anastomosis was measured, and a biochemical analysis was performed for elastin and collagen content.
  
  
  RESULTS
  Bolstered anastomoses offered no strength advantage as burst pressures were no different when compared with unbolstered anastomoses. There was also no difference in anastomotic internal diameter, biochemical analysis of elastin or collagen, or presence of adhesions when comparing bolstered with unbolstered anastomoses. There were 4 subclinical leaks-1 in the unbolstered group and 3 in the bolstered group.
  
  
  CONCLUSIONS
  The routine use of 1.5:1 meshed AlloDerm sandwich bolsters in stapled rectal anastomosis does not confer any detectable advantage in anastomotic strength. Further studies are needed to determine equivalence to traditional stapled anastomoses.
authors.affiliation: Washington University in St Louis, St Louis, MO, USA.
authors.forename: Alyssa D
authors.initials: AD
authors.lastname: Fajardo
authors.forename: Jonathan
authors.initials: J
authors.lastname: Chun
authors.forename: David
authors.initials: D
authors.lastname: Stewart
authors.forename: Bashar
authors.initials: B
authors.lastname: Safar
authors.forename: James W
authors.initials: JW
authors.lastname: Fleshman
mesh_terms: D000714:Anastomosis, Surgical; D057868:Anastomotic Leak / Q000517:prevention & control*; D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D003106:Colon / Q000601:surgery*; D005260:Female; D023421:Models, Animal; D012007:Rectum / Q000601:surgery*; D013526:Surgical Mesh; D017792:Surgical Stapling; D013552:Swine; D013718:Tensile Strength
chemical_list: C440568:Alloderm; D003094:Collagen