title: (R)evolution of complex regulatory systems.
abstract: Signaling systems are exciting to study precisely because they are some of the most complex and dynamical systems that we know. The cell needs operational freedom and, thus, many motif-domain interactions might not be "hard-wired" through evolution, but instead may be like the Linux operating system, where symbolic links can point to files without duplication.
authors.forename: Rune
authors.initials: R
authors.lastname: Linding
mesh_terms: D001695:Biology / Q000379:methods / Q000639:trends; D002468:Cell Physiological Phenomena; D004777:Environment; D005818:Genetic Engineering / Q000639:trends; D006706:Homeostasis / Q000502:physiology*; D010766:Phosphorylation; D020543:Proteome / Q000378:metabolism; D015398:Signal Transduction; D013561:Symbolism
chemical_list: D020543:Proteome