Seroprevalence of HTLV-1 among kidney graft recipients: a single-center study.
BACKGROUND
Renal transplant recipients are susceptible to viral infections because of their immunocompromised background. HTLV-1 is a retrovirus that leads to adult T-cell leukemia/lymphoma or myelopathies. This study aimed to evaluate HTLV-1 antibodies among renal transplant recipients in Urmia, Iran.


METHODS
Serum samples of 91 renal transplant recipients from Urmia, Iran, were examined serologically for antibodies against HTLV type 1 using an enzyme-linked immunosorbent assay.


RESULTS
Mean age was 37.26 +/- 14.22 years old. Only 1 patient had a positive anti-HTLV-1 enzyme-linked immunosorbent assay test, which was confirmed by Western blot. The HTLV-1-positive case did not have HTLV-associated clinical manifestation. This patient was a 45-year-old man, with no history of blood transfusion, but he did have a history of hemodialysis before transplant.


CONCLUSIONS
The frequency of HTLV-1 among renal transplant recipients of our region in the northwest of Iran was not so high, and it is similar to the HTLV- 1 seroprevalence among hemodialysis patients. Still, it is more frequent among healthy blood donors as representative of the general population in our region.
Khameneh
Zakieh Rostamzadeh
ZR
Department of Microbiology and Immunology, Umria University of Medical Sciences, Urmia, Iran.
Sepehrvand
Nariman
N
Masudi
Sima
S
Taghizade-Afshari
Ali
A
D000328:Adult; D015153:Blotting, Western; D003430:Cross-Sectional Studies; D006800:Deltaretrovirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult
D015481:HTLV-I Antibodies