title: [A case of cholangiocarcinoma suspected by continuous elevation of CA 19-9 after surgery of xanthogranulomatous cholecystitis].
abstract: Xanthogranulomatous cholecystitis (XGC) is an unusual and destructive inflammatory process that is characterized by thickening of the gallbladder (GB) wall with a tendency to adhere to neighboring organs. XGC is often mistaken for GB carcinoma, and the frequency of the coexistence of these two lesions is approximately 10%. Therefore, in case of severe XGC, there is chance of either overlooking the carcinoma or other significant lesions. CA 19-9 is commonly measured in the serum of patients with hepatobiliary malignancies. Although CA 19-9 can be elevated in benign conditions such as cholestasis, pancreatitis, tuberculosis, thyroid disease etc., malignancy should be considered at first in setting of its significant and persistent elevation. We report a case of a 62-year-old man who showed continuously rising level of CA19-9 over 2000 U/mL after cholecystectomy for xanthogranulomatous cholecystitis and finally was diagnosed as cholangiocarcinoma by short-term follow up.
authors.affiliation: Departments of Internal Medicine, Seoul National University College of Medicine, SMG-SNU Borame Medical Center, Seoul, Korea.
authors.forename: Sang Youn
authors.initials: SY
authors.lastname: Hwang
authors.forename: Joon Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Ji Bong
authors.initials: JB
authors.lastname: Jeong
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Byeong Gwan
authors.initials: BG
authors.lastname: Kim
authors.forename: Kook Lae
authors.initials: KL
authors.lastname: Lee
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Ahn
authors.forename: Mee Soo
authors.initials: MS
authors.lastname: Chang
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D001653:Bile Ducts, Intrahepatic; D018395:CA-19-9 Antigen / Q000097:blood*; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002764:Cholecystitis / Q000473:pathology / Q000601:surgery*; D006099:Granuloma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D014973:Xanthomatosis / Q000473:pathology / Q000601:surgery*
chemical_list: D018395:CA-19-9 Antigen