Cytotoxic triterpenoid glycosides from the roots of Gordonia chrysandra.
Eight new oleanane triterpenoid glycosides, gordonosides A-H (1-8), were isolated from a 50% EtOH extract of the roots of Gordonia chrysandra. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR and ESIMS, and by chemical methods. Among these substances, compounds 1, 3, 5, and 6 exhibited cytotoxic activity against several human cancer cell lines, with 3 being the most potent.
Yu
Lei
L
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education, Beijing 100050, People's Republic of China.
Yang
Jing-Zhi
JZ
Chen
Xiao-Guang
XG
Shi
Jian-Gong
JG
Zhang
Dong-Ming
DM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D028242:Theaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; C413246:oleanane; D009828:Oleanolic Acid