title: Efficacy of 7-valent pneumococcal conjugate vaccination in Germany: An analysis using the indirect cohort method.
abstract: Efficacy of 7-valent pneumococcal conjugate vaccination has been shown in randomized controlled trials using 4 dose vaccination schedules in children under 2 years of age. A case-control study from the US showed considerable protection from IPD for reduced vaccination schedules and even some protection from only one dose. In Germany, delayed and incomplete vaccination is a major issue. We assessed efficacy of PCV7 using data on cases of IPD from active surveillance and applying the indirect cohort design proposed by Broome, comparing cases of IPD with a vaccine serotype with cases with a non-vaccine serotype. Efficacy of at least one dose of PCV7 was estimated to be 88.3% (95% CI: 64.0-96.6). Estimates of efficacy for one, two, and three doses in the first 7 months of life were 78.1% (3.4-96.1), 89.8% (20.6-100.0), and 94.6% (69.7-99.5) respectively. Our study adds to evidence of good protection from IPD by reduced vaccination schedules with PCV7, e.g. with two doses as primary series, in a setting where a high proportion of children receives vaccination delayed.
authors.affiliation: Ludwig-Maximilians-University of Munich, Institute of Social Pediatrics and Adolescent Medicine, Division of Epidemiology, Heiglhofstr. 63, 81377 München, Germany. simon.rueckinger@med.uni-muenchen.de
authors.forename: Simon
authors.initials: S
authors.lastname: Rückinger
authors.forename: Mark
authors.initials: M
authors.lastname: van der Linden
authors.forename: Ralf René
authors.initials: RR
authors.lastname: Reinert
authors.forename: Rüdiger
authors.initials: R
authors.lastname: von Kries
mesh_terms: D002675:Child, Preschool; D005260:Female; D005858:Germany / Q000453:epidemiology; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011159:Population Surveillance; D011446:Prospective Studies; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate