title: Morphological fractal analysis of shape in cancer cells treated with combinations of microtubule-polymerizing and -depolymerizing agents.
abstract: The current prognostic parameters, including tumor volume, biochemistry, or immunohistochemistry, are not sufficient to reflect the properties of cancer cells that distinguish them from normal cells. Our focus is to evaluate the effects of a combination of microtubule-polymerizing Taxol and -depolymerizing colchicine on IAR20 PC1 liver cells by measuring the surface fractal dimension as a descriptor of two-dimensional vascular geometrical complexity. The fractal dimension offers a rapid means of assessing cell shape. Furthermore, we show correlations of fractal dimensions of cell contours with the latent factors from our previously employed cell shape analysis.
authors.affiliation: Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
authors.forename: Sonal O
authors.initials: SO
authors.lastname: Uppal
authors.forename: Dmitri V
authors.initials: DV
authors.lastname: Voronine
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wendt
authors.forename: Carol A
authors.initials: CA
authors.lastname: Heckman
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D048430:Cell Shape / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003584:Cytological Techniques / Q000379:methods*; D022781:Hepatocytes / Q000187:drug effects* / Q000648:ultrastructure*; D008853:Microscopy / Q000379:methods; D008870:Microtubules / Q000187:drug effects* / Q000648:ultrastructure*; D017239:Paclitaxel / Q000494:pharmacology; D051381:Rats; D050257:Tubulin Modulators / Q000494:pharmacology*
chemical_list: D050257:Tubulin Modulators; D017239:Paclitaxel; D003078:Colchicine