Takayasu arteritis in children and adolescents.
Takayasu arteritis is a devastating vasculitis of the aorta and its major branches. The clinical manifestations in paediatric patients are less specific than in adults: in children the disease presents with fever, arthralgias and hypertension. Intramural inflammation results in narrowing of the blood vessel lumen and therefore hypoperfusion of the parenchyma. Conventional angiography is the gold standard diagnostic procedure. Corticosteroids, cyclophosphamide, MTX and biological therapies such as TNF-α blocking agents are treatment options.
Brunner
Juergen
J
Department of Pediatrics, Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria. juergen.brunner@uki.at
Feldman
Brian M
BM
Tyrrell
Pascal N
PN
Kuemmerle-Deschner
Jasmin B
JB
Zimmerhackl
Lothar B
LB
Gassner
Ingmar
I
Benseler
Susanne M
SM
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D000792:Angiography / Q000379:methods; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D013625:Takayasu Arteritis / Q000188:drug therapy* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*; D055815:Young Adult
D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide