[Pathophysiology of immune thrombocytopenia].
Immune thrombocytopenia is an autoimmune disease characterized by a peripheral destruction of platelets. B lymphocytes play a key role but pathogenesis is more complex, involving humoral and cellular immunity associated with an inappropriate platelet production. In this article, we review the different pathogenic pathways, leading to new therapeutic strategies.
Audia
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S
Service de médecine interne et immunologie clinique, centre de compétence des cytopénies auto-immunes de Bourgogne Franche-Comté, hôpital du Bocage, CHU de Dijon, 2 boulevard Maréchal-de-Lattre-de-Tassigny, Dijon, France. sylvain.audia@chu-dijon.fr
Lorcerie
B
B
Godeau
B
B
Bonnotte
B
B
D001327:Autoimmune Diseases / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D013921:Thrombocytopenia / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology*