title: The role of central hypersensitivity in the determination of intradiscal mechanical hyperalgesia in discogenic pain.
abstract: OBJECTIVE
  The primary aim of the present study was to investigate whether there is a relationship between central hypersensitivity (assessed by pressure pain thresholds of uninjured tissues) and intradiscal pain threshold during discography. The secondary aim was to test the hypothesis that peripheral noxious stimulation dynamically modulates central hypersensitivity.
  
  
  METHODS
  Twenty-four patients with positive provocation discography were tested for central hypersensitivity by pressure algometry before and after the intervention with assessments of pressure pain detection and tolerance thresholds. Intradiscal pain threshold was assessed by measuring intradiscal pressure at the moment of pain provocation during discography. Correlation analyses between intradiscal pain threshold and pressure algometry were made. For the secondary aim, pressure algometry data before and after discography were compared.
  
  
  RESULTS
  Significant correlation with intradiscal pain threshold was found for pressure pain detection threshold at the toe (regression coefficient: 0.03, P = 0.05) and pressure pain tolerance thresholds at the nonpainful point at the back (0.02, P = 0.024). Tolerance threshold at the toe was a significant predictor for intradiscal pain threshold only in multiple linear regression (0.036, P = 0.027). Detection as well as tolerance thresholds significantly decreased after discography at the painful and the nonpainful point at the back, but not at the toe.
  
  
  CONCLUSIONS
  Central hypersensitivity may influence intradiscal pain threshold, but with a modest quantitative impact. The diagnostic value of provocation discography is therefore not substantially impaired. Regional, but not generalized central hypersensitivity is dynamically modulated by ongoing peripheral nociceptive input.
authors.affiliation: University Department of Anaesthesiology and Pain Therapy, Inselspital, 3010 Bern, Switzerland. juerg.schliessbach@insel.ch
authors.forename: Juerg
authors.initials: J
authors.lastname: Schliessbach
authors.forename: Lars
authors.initials: L
authors.lastname: Arendt-Nielsen
authors.forename: Paul
authors.initials: P
authors.lastname: Heini
authors.forename: Michele
authors.initials: M
authors.lastname: Curatolo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D006967:Hypersensitivity / Q000503:physiopathology*; D007403:Intervertebral Disc / Q000473:pathology*; D017116:Low Back Pain / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D017288:Pain Threshold; D011312:Pressure