title: Evaluation of supercritical fluid extraction in the pharmaceutical industry.
abstract: Various steroids precipitate from supercritical CO(2) as very small particles but still retain their crystallinity. This suggests that SCFE in this industry could be utilized as a size reduction method as an alternative to milling. The application of SCFE as a separation technique is demonstrated by the simultaneous extraction and reaction of mevinolin, a metabolite of the fungus Aspergillus terreus.
authors.affiliation: Merck Sharp & Dohme Research Laboratories P.O. Box 2000 Rahway, New Jersey 07065.
authors.forename: K A
authors.initials: KA
authors.lastname: Larson
authors.forename: M L
authors.initials: ML
authors.lastname: King