[Retrospective analysis of tuberculosis caused by Mycobacterium bovis 2004 - 2008].
BACKGROUND
mycobacterium bovis is a rare cause of tuberculosis in Germany. Epidemiological data are sparse.


METHODS
we have carried out a retrospective analysis of all patients diagnosed with tuberculosis caused by M. BOVIS in a pneumological referral centre between 2004 and 2008.


RESULTS
M. bovis was isolated in 8 out of 203 (3,9  %) patients with a new diagnosis of tuberculosis. The median age of these patients was 69 years, and 7 out of 8 showed risk factors for reactivation of a latent tuberculosis infection. In 4 patients (50  %) an extrapulmonary manifestation was present. All isolates of M. bovis were resistant to pyrazinamide, one isolate had an additional resistance to isoniazide. In 6 out of 8 patients prolonged tuberculostatic treatment of 8 - 12 months was recommended.


CONCLUSIONS
the proportion of tuberculosis caused by M. bovis was higher than that reported for Germany (3.9 vs. 1,5 %). Predominantly elderly patients with risk factors for reactivation of a latent tuberculosis infection were affected. In accordance with the literature a high rate of extrapulmonary manifestations was detected. Because of the genetic resistance of M. bovis to pyrazinamide prolonged antimycobacterial treatment is recommended.
Kolditz
M
M
Abteilung für PulmologieMedizinische, Klinik undPoliklinik I, Universitätsklinikum Carl Gustav CarusFetscherstr, Dresden. martin.kolditz@uniklinikumdresden.de
Koschel
D
D
Philipp
E
E
Höffken
G
G
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000302:isolation & purification*; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*