title: The effect of acute fish-oil supplementation on endothelial function and arterial stiffness following a high-fat meal.
abstract: This study examined whether a commercially available fish-oil supplement offers protection from the acute effects of a high-fat meal (HFM) on endothelial function and arterial stiffness. An HFM causes acute impairments in endothelial function, whereas the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have a variety of cardioprotective effects. However, little is known about the efficacy of moderate fish-oil supplementation on the endothelial dysfunction induced by an HFM. Endothelial function (brachial artery flow-mediated dilation (FMD)), forearm blood flow (FBF), total hyperemia, central and peripheral blood pressure, and central artery stiffness were assessed in 20 healthy men (n = 10) and women (n = 10) at rest and 4 h after an HFM supplemented with either placebo or approximately 1 g EPA and DHA. Brachial artery FMD normalized for shear rate was significantly impaired (p = 0.033) following the HFM with placebo but remained unchanged compared with baseline following the HFM with the fish-oil supplement (p = 0.039; condition x time interaction). Resting FBF (p = 0.020) and total hyperemia (p = 0.014) were elevated following the HFM. All other vascular and hemodynamic measurements were unchanged in both trials. Commercially available fish-oil supplements taken with an HFM appear to preserve endothelial function following an HFM.
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 68121, USA. chris.fahs@ou.edu
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Fahs
authors.forename: Huimin
authors.initials: H
authors.lastname: Yan
authors.forename: Sushant
authors.initials: S
authors.lastname: Ranadive
authors.forename: Lindy M
authors.initials: LM
authors.lastname: Rossow
authors.forename: Stamatis
authors.initials: S
authors.lastname: Agiovlasitis
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Wilund
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
mesh_terms: D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology; D001158:Arteries / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects / Q000503:physiopathology; D002339:Carotid Arteries / Q000187:drug effects / Q000503:physiopathology; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000009:adverse effects*; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage*; D004548:Elasticity; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects*; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D004338:Drug Combinations; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid