title: Toward an integrated research agenda for critical illness in aging.
abstract: Aging brings an increased predisposition to critical illness. Patients older than 65 years of age account for approximately half of all intensive care unit (ICU) admissions in the United States, a proportion that is expected to increase considerably with the aging of the population. Emerging research suggests that elderly survivors of intensive care suffer significant long-term sequelae, including accelerated age-related functional decline. Existing evidence-based interventions are frequently underused and their efficacy untested in older subjects. Improving ICU outcomes in the elderly will require not only better methods for translating sound science into improved ICU practice but also an enhanced understanding of the underlying molecular, physiological, and pathophysiological interactions of critical illness with the aging process itself. Yet, significant barriers to research for critical illness in aging exist. We review the state of knowledge and identify gaps in knowledge, research opportunities, and barriers to research, with the goal of promoting an integrated research agenda for critical illness in aging.
authors.affiliation: The CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Milbrandt
authors.forename: Basil
authors.initials: B
authors.lastname: Eldadah
authors.forename: Susan
authors.initials: S
authors.lastname: Nayfield
authors.forename: Evan
authors.initials: E
authors.lastname: Hadley
authors.forename: Derek C
authors.initials: DC
authors.lastname: Angus
mesh_terms: D000368:Aged; D003422:Critical Care / Q000458:organization & administration*; D006301:Health Services Needs and Demand; D006299:Health Services for the Aged / Q000458:organization & administration*; D006801:Humans; D011787:Quality of Health Care; D012106:Research; D057170:Translational Research, Biomedical; D014481:United States