title: Expression of 2 transcripts of NGX6 gene in colorectal cancer and the correlation with carcinoembryonic antigen.
abstract: OBJECTIVE
  To investigate the expression and function of NGX6-S (short transcript) and NGX6-L (long transcript) in colorectal cancer.
  
  
  METHODS
  In situ hybridization was used to detect the expression of these 2 transcripts in colorectal cancer tissues and paired normal tissues, and analyze the correlation between NGX6 and carcinoembryonic antigen (CEA).
  
  
  RESULTS
  The expression of NGX6-S was higher than that of NGX6-L in the colorectal cancer tissues (P=0.008). The expressions of NGX6-S and NGX6-L were not different among the 4 stages of colorectal cancer (P>0.05). The expression of NGX6-S in the colorectal cancer tissues of Duke A, B, and C stages had no difference with that of the paired normal tissues (P>0.05). Inversely, the expression of NGX6-S in the colorectal cancer tissues of Duke D stage was lower than that in the paired normal tissues (P=0.033). NGX6-L expression was not different between the colorectal cancer tissues and the paired normal tissues in 4 stages(P>0.05).The expression of NGX6-S and NGX6-L had no correlation with the serum concentration of CEA.
  
  
  CONCLUSIONS
  NGX6-S may play an important role in colorectal cancer, and the lowered expression of NGX6-S may contribute to the distant metastasis of colorectal cancer.
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Su
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Shourong
authors.initials: S
authors.lastname: Shen
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Zeng
authors.initials: Z
authors.lastname: Li
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D002272:Carcinoembryonic Antigen; D008565:Membrane Proteins; C477325:TMEM8B protein, human; D025521:Tumor Suppressor Proteins