Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12, 0.85) with 25(OH)D concentrations of > or =75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.
Gallicchio
Lisa
L
Mercy Medical Center, Baltimore, Maryland 21202, USA. lgallic@mdmercy.com
Moore
Lee E
LE
Stevens
Victoria L
VL
Ahn
Jiyoung
J
Albanes
Demetrius
D
Hartmuller
Virginia
V
Setiawan
V Wendy
VW
Helzlsouer
Kathy J
KJ
Yang
Gong
G
Xiang
Yong-Bing
YB
Shu
Xiao-Ou
XO
Snyder
Kirk
K
Weinstein
Stephanie J
SJ
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
Zheng
Wei
W
Cai
Qiuyin
Q
Campbell
David S
DS
Chen
Yu
Y
Chow
Wong-Ho
WH
Horst
Ronald L
RL
Kolonel
Laurence N
LN
McCullough
Marjorie L
ML
Purdue
Mark P
MP
Koenig
Karen L
KL
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000453:epidemiology* / Q000517:prevention & control*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D016015:Logistic Models; D008297:Male; D015201:Meta-Analysis as Topic; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
D014807:Vitamin D