[Fetal inflammatory response in the development of multiple organ dysfunction in newborn].
The fetal inflammatory response syndrome (FIRS) is one of the causes of multiple organ dysfunction (MOD) in critically ill newborn infants. The paper shows a role of interleukin-8 (IL-8) in the development of FIRS and MOD in neonates a correlation between the concentration of IL-8 and the number of organs involved in the pathological process and demonstrates the leading role of endothelial dysfunction in the pathogenesis of the pathological processes concerned.
Sergeeva
V A
VA
Nesterenko
S N
SN
Shabalov
N P
NP
Aleksandrovich
Iu S
IuS
D015415:Biomarkers / Q000097:blood; D004730:Endothelium, Vascular / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000097:blood*; D009102:Multiple Organ Failure / Q000097:blood* / Q000196:embryology / Q000453:epidemiology / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000150:complications / Q000196:embryology* / Q000453:epidemiology / Q000276:immunology
D015415:Biomarkers; D016209:Interleukin-8