title: [Diagnostic and pathogenetic implications of the site specificity of antibody proteases in multiple sclerosis].
abstract: Disseminated sclerosis is currently regarded as a CNS autoimmune disease. One of the mechanisms behind this pathology is antibody (AB) formation. In this context, recent data on AB with proteolytic activity are of importance because they participate in selective proteolysis of myelin proteins in patients with disseminated sclerosis. This paper focuses on AB-proteases associated with disseminated sclerosis and site-specificity of antibody-mediated proteolysis of myelin basic protein. Protocol of serodiagnostic algorithm to be used in clinical practice is described.
authors.forename: O V
authors.initials: OV
authors.lastname: Salafet
authors.forename: N D
authors.initials: ND
authors.lastname: Ruzina
authors.forename: N A
authors.initials: NA
authors.lastname: Ponomarenko
authors.forename: A
authors.initials: A
authors.lastname: Friboulet
authors.forename: M V
authors.initials: MV
authors.lastname: Kimova
authors.forename: T E
authors.initials: TE
authors.lastname: Shmidt
authors.forename: A G
authors.initials: AG
authors.lastname: Gabibov
authors.forename: H K
authors.initials: HK
authors.lastname: Morse
authors.forename: M A
authors.initials: MA
authors.lastname: Pal'tsev
authors.forename: S V
authors.initials: SV
authors.lastname: Suchkov
mesh_terms: D000595:Amino Acid Sequence; D000918:Antibody Specificity; D000938:Antigen-Presenting Cells / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D000939:Epitopes; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D012698:Serologic Tests; D013379:Substrate Specificity
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D004676:Myelin Basic Protein; D010447:Peptide Hydrolases