title: Two-component approach toward a fully substituted N-fused pyrrole ring.
abstract: An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Chernyak
authors.forename: Cathy
authors.initials: C
authors.lastname: Skontos
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D011758:Pyrroles; D010165:Palladium; D009584:Nitrogen