title: Serum interleukin-5 levels correlate with disease activity of Churg-Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid.
abstract: This case report demonstrates that interleukin (IL)-5 levels and eosinophil cationic protein (ECP) correlated well with disease activity of Churg-Strauss syndrome (CSS) in a patient receiving treatment with leucotriene receptor antagonist and inhaled corticosteroid. In addition, ECP was localized in the inflamed tissue. IL-5 levels may thus provide a clue to therapeutic efficacy in patients with CSS using leucotriene receptor antagonists and inhaled corticosteroid.
authors.affiliation: First Department of Internal Medicine, University of Toyama, Sugitani, Toyama, Japan. htaki-tym@umin.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Taki
authors.forename: K
authors.initials: K
authors.lastname: Shinoda
authors.forename: H
authors.initials: H
authors.lastname: Hounoki
authors.forename: R
authors.initials: R
authors.lastname: Ogawa
authors.forename: S
authors.initials: S
authors.lastname: Ishizawa
authors.forename: E
authors.initials: E
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Tobe
mesh_terms: D000328:Adult; D000730:Androstadienes / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002867:Chromones / Q000627:therapeutic use*; D015267:Churg-Strauss Syndrome / Q000097:blood* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D047150:Eosinophil Cationic Protein / Q000097:blood; D000068298:Fluticasone; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D002867:Chromones; D015848:Interleukin-5; D020024:Leukotriene Antagonists; D015375:Receptors, Interleukin-2; D000068298:Fluticasone; D047150:Eosinophil Cationic Protein; C047681:pranlukast