title: Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology.
abstract: Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.
authors.affiliation: Department of Pharmacology and Neuroscience, Tulane University Medical School, New Orleans, Louisiana 70112, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Stewart
authors.forename: Keith
authors.initials: K
authors.lastname: Wong
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cachat
authors.forename: Marco
authors.initials: M
authors.lastname: Elegante
authors.forename: Tom
authors.initials: T
authors.lastname: Gilder
authors.forename: Sopan
authors.initials: S
authors.lastname: Mohnot
authors.forename: Nadine
authors.initials: N
authors.lastname: Wu
authors.forename: Anna
authors.initials: A
authors.lastname: Minasyan
authors.forename: Pentti
authors.initials: P
authors.lastname: Tuohimaa
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D001927:Brain Diseases / Q000188:drug therapy / Q000503:physiopathology; D016503:Drug Delivery Systems; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology; D018167:Receptors, Calcitriol / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D