[Post-modification oxygenases in the biosynthesis of aromatic polyketides--a review].
Oxygenases are common tailoring enzymes involved in the biosynthesis of aromatic polyketides, they are critical determinants of the final structure of aromatic polyketides. Here we review the structures and functions of several classes of oxygenases found in the biosynthetic gene clusters of aromatic polyketides. We used the oxygenases (JadFGH) in jadomycin biosynthesis as examples to elucidate the complex roles these oxygenases play and discussed the future prospects of using oxygenases in combinatorial biosynthesis.
Ji
Junjie
J
Shandong Normal University, Jinan 250014, China. jijunjie_2004@163.com
Fan
Keqiang
K
Peng
Xiaojing
X
Tian
Xiuyun
X
Dai
Meixue
M
Yang
Keqian
K
D024322:Amino Acids, Aromatic / Q000096:biosynthesis*; D007546:Isoquinolines / Q000737:chemistry; D018942:Macrolides / Q000378:metabolism*; D010105:Oxygenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
D024322:Amino Acids, Aromatic; D007546:Isoquinolines; D018942:Macrolides; C081750:jadomycin B; D010105:Oxygenases