Distinct biological network properties between the targets of natural products and disease genes.
We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.
Dancík
Vlado
V
Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02143, USA.
Seiler
Kathleen Petri
KP
Young
Damian W
DW
Schreiber
Stuart L
SL
Clemons
Paul A
PA
D001688:Biological Products / Q000494:pharmacology*; D004194:Disease / Q000235:genetics*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000187:drug effects / Q000378:metabolism*; D049490:Systems Biology / Q000379:methods*
D001688:Biological Products; D011506:Proteins