title: A clinical trial of pulpotomy vs. root canal therapy of mature molars.
abstract: Root canal therapy (RCT) and tooth extraction are the main treatment options for irreversible pulpitis or its sequelae. Pulpotomy is an alternative treatment; however, more evidence is required. If outcomes of pulpotomy with a calcium-enriched mixture (PCEM) are non-inferior for mature molars with irreversible pulpitis compared with those from one-visit RCT (ORCT), this may be a beneficial treatment option. Four hundred seven individuals met the inclusion criteria and were randomly allocated [PCEM (n = 205), ORCT (n = 202)]. We used NRS questionnaires to record pain intensity. Six-month clinical and radiographic successes were assessed. Individuals in the ORCT arm reported significantly more post-operative pain than those in the PCEM arm (P < 0.001). Clinical success rates in the two arms showed no statistically significant difference; however, the radiographic success rates were significantly greater in the PCEM arm (P < 0.001). This trial suggests PCEM as an alternative for treatment of irreversible pulpitis. If long-term results confirm initial ones, PCEM may revolutionize oral health worldwide.
authors.affiliation: Iranian Center for Endodontic Research, Dental Research Center, Dental School, Shahid Beheshti University MC, Evin, Postal Code 1983963113, Tehran, Iran. saasgary@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Asgary
authors.forename: M J
authors.initials: MJ
authors.lastname: Eghbal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D017610:Calcium Compounds / Q000627:therapeutic use; D002133:Calcium Sulfate / Q000627:therapeutic use; D002648:Child; D003738:Dental Cements / Q000627:therapeutic use; D004853:Epoxy Resins / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005898:Glass; D006171:Gutta-Percha / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008963:Molar / Q000473:pathology*; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D011145:Polyvinyls / Q000627:therapeutic use; D011671:Pulpitis / Q000628:therapy*; D011672:Pulpotomy / Q000379:methods*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012390:Root Canal Therapy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult; D015034:Zinc Oxide / Q000627:therapeutic use
chemical_list: D000700:Analgesics; C509301:CaO-MgO-SiO2 glass; D017610:Calcium Compounds; D003738:Dental Cements; D004853:Epoxy Resins; D011145:Polyvinyls; D012387:Root Canal Filling Materials; C417772:calcium oxide-diphosphorus pentoxide-silicon dioxide-aluminum oxide glass; C534916:epoxy resin-based root canal sealer; C020872:Cavit; D006171:Gutta-Percha; D015034:Zinc Oxide; D002133:Calcium Sulfate