The trail of my studies on glycoproteins from enterokinase to tumor markers.
This review describes the results of the author's studies on glycoproteins which have been carried out for more than 50 years. Starting from the elucidation of basic structures of glycoproteins, i.e. the structure of the linkage between an amino acid and a sugar and the occurrence of the beta-mannosidic linkage as the common structure of glycoproteins, the author became interested in the cell membrane glycoproteins focused on the comparison of cancer cells versus normal cells. These studies were then extended to the establishment of sugar-directed and cancer-associated monoclonal antibodies. Some of the monoclonal antibodies are useful for cancer diagnosis.
Yamashina
Ikuo
I
Kyoto University, Kyoto, Japan. ikuyama@mbe.ocn.ne.jp
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D014408:Biomarkers, Tumor / Q000737:chemistry / Q000378:metabolism; D004765:Enteropeptidase / Q000737:chemistry / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D004765:Enteropeptidase