title: Feticide followed by mifepristone-misoprostol regimen for midtrimester termination of pregnancy in two cases of complete placenta previa.
abstract: Placenta previa (PP), with a frequency of 5-7% in the second trimester, is considered one of the most important causes of obstetric hemorrhage. Surgical curettage is the classically recommended method to perform a midtrimester termination of pregnancy (TOP) in the presence of PP. Recent clinical reports suggest that induction of delivery is possible in these cases, but no information on mifepristone-misoprostol regimen is available. We present 2 cases of mifepristone-misoprostol midtrimester TOP with a diagnosis of complete PP. In both cases, a preinduction feticide was performed. Neither of the 2 cases presented a significant maternal bleeding. This report is relevant considering that this regimen is the most widely used and generally reported as the safest and most effective medical midtrimester TOP method.
authors.affiliation: Department of Maternal-Fetal Medicine/ICGON, Hospital Clínic, University of Barcelona, c/Sabino de Arana 1, Barcelona, Spain. ogomez@clinic.ub.es
authors.forename: A
authors.initials: A
authors.lastname: Borrás
authors.forename: O
authors.initials: O
authors.lastname: Gómez
authors.forename: M
authors.initials: M
authors.lastname: Sanz
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez
authors.forename: B
authors.initials: B
authors.lastname: Puerto
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000032:Abortion, Therapeutic / Q000379:methods*; D000284:Administration, Oral; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000627:therapeutic use*; D016595:Misoprostol / Q000008:administration & dosage / Q000627:therapeutic use*; D010923:Placenta Previa; D006473:Postpartum Hemorrhage / Q000517:prevention & control; D011189:Potassium Chloride / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D015735:Mifepristone; D011189:Potassium Chloride