title: Vascular cryografts offer better biomechanical properties in chronically hemodialyzed patients: role of cryograft type, arterial pathway, and diabetic nephropathy as matching determinants.
abstract: This study aimed to characterize the following: (i) in chronically hemodialyzed subjects (CHDSs), with and without diabetic nephropathy (DN), and in healthy subjects (non-CHDSs) different arterial pathways stiffness to determine potential pathology-dependent, etiology- and/or pathway-dependent differences; and (ii) the biomechanical mismatch (BM) between arteries from non-CHDSs or CHDSs (with and without DN) and arterial cryografts, venous cryografts, and synthetic prosthesis to determine arterial pathway, pathology, and/or etiology-related differences in the substitute of election in terms of BM. Carotid-femoral and carotid-brachial pulse wave velocity (PWV) were measured in 30 non-CHDSs and 71 CHDSs (11 with DN). In addition, PWV was measured in arterial (elastic and muscular) and venous cryografts and in expanded polytetrafluorethylene prosthesis. The arterial pathways regional differences and the subjects' arterial pathways-substitutes BM were calculated. Arterial stiffness levels and regional differences were higher in CHDS than in non-CHDS. Among CHDS, those with DN showed higher stiffness in the aorto-femoral pathway and larger regional differences. Cryografts showed always the least BM. Non-CHDS and CHDS differed in the cryograft of election. In CHDS, the BM was related with the cryograft type, arterial pathway, and renal disease etiology. The BM could be minimized, selecting the most adequate cryograft type, taking into account the recipient specific characteristic (i.e., arterial pathway and renal disease etiology).
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. yana@fmed.edu.uy
authors.forename: Yanina
authors.initials: Y
authors.lastname: Zócalo
authors.forename: Daniel
authors.initials: D
authors.lastname: Bia
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Armentano
authors.forename: Cintia
authors.initials: C
authors.lastname: Galli
authors.forename: Héctor
authors.initials: H
authors.lastname: Pérez
authors.forename: María
authors.initials: M
authors.lastname: Saldías
authors.forename: Inés
authors.initials: I
authors.lastname: Alvarez
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Valtuille
authors.forename: Edmundo
authors.initials: E
authors.lastname: Cabrera-Fischer
mesh_terms: D000368:Aged; D001158:Arteries / Q000502:physiology* / Q000637:transplantation; D001696:Biomechanical Phenomena; D001807:Blood Vessel Prosthesis; D015925:Cryopreservation; D003928:Diabetic Nephropathies / Q000503:physiopathology* / Q000628:therapy; D004548:Elasticity; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011674:Pulse; D006435:Renal Dialysis; D019737:Transplants
chemical_list: D011138:Polytetrafluoroethylene