Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men.
OBJECTIVE
We questioned whether the ratio of C-reactive protein to high-molecular-weight adiponectin (C/A ratio), compared to each value alone, is more useful to predict insulin resistance and/or metabolic syndrome.


METHODS
We measured serum CRP and HMW adiponectin levels in 841 Japanese men who had participated in an annual health checkup. Correlations of the C/A ratio with metabolic parameters were assessed, and its predictive values for insulin resistance and MetS were compared with CRP or HMW adiponectin alone.


RESULTS
The C/A ratio was higher in subjects with MetS (n = 114) than in those without MetS (0.46 ± 0.67 vs. 0.23 ± 0.39, p<0.0001). The C/A ratio was correlated with a larger number of metabolic parameters than CRP, but the correlation was comparable to HMW adiponectin. Likewise, the area under the curve of the C/A ratio in receiver operator characteristic analysis for MetS was greater than that of CRP, but comparable to that of HMW adiponectin. However, the AUC of the C/A ratio in ROC analysis for insulin resistance (HOMA-IR >2.5) was greater than that of CRP or HMW adiponectin alone.


CONCLUSIONS
While the C/A ratio provided little advantage to predict MetS, it might be more useful to predict insulin resistance than CRP or HMW adiponectin alone.
Saisho
Yoshifumi
Y
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Hirose
Hiroshi
H
Seino
Yoshie
Y
Saito
Ikuo
I
Itoh
Hiroshi
H
D052242:Adiponectin / Q000097:blood / Q000737:chemistry; D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis; D008875:Middle Aged; D008970:Molecular Weight; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein