Conventional and microwave assisted synthesis of some new N-[(4-oxo-2-substituted aryl -1, 3-thiazolidine)-acetamidyl]-5-nitroindazoles and its antimicrobial activity.
Several new N-[(4-oxo-2-substituted aryl-1, 3-thiazolidine)-acetamidyl]-5-nitroindazoles (4a-l) were synthesized from N-(arylidene amino acetamidyl)-5-nitroindazoles (3a-l). The reactions were carried out by both conventional as well as microwave method. The structures of these compounds were confirmed by IR, (1)H NMR, (13)C NMR, FAB-mass spectra and also by microanalytical data. The newly synthesized compounds were evaluated for their antimicrobial activity against variety of bacterial and fungal strains. The compounds 4 g and 4 h showed the maximum antibacterial activity (MIC 11 and 10 microg/mL) against Escherichia coli and antifungal activity (MIC 9 and 8 microg/mL) against Fusarium oxysporum.
Upadhyay
Apoorva
A
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour University (A Central University), Sagar (M.P.) 470 003, India. upadhyay.apoorva@gmail.com
Srivastava
S K
SK
Srivastava
S D
SD
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D013057:Spectrum Analysis
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D007191:Indazoles