BRAGging about mechanisms of long-term depression.
The mechanisms of long-term depression (LTD) underlie various aspects of normal brain function. Therefore, it is important to understand the signaling that underpins LTD. The study by Scholz et al. in this issue of Neuron describes how BRAG2, mGluRs, and AMPARs come together to produce LTD through AMPAR internalization.
Fitzjohn
Stephen M
SM
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, UK.
Bashir
Zafar I
ZI