Constitutional inv(3) in myelodysplastic syndromes.
The constitutional pericentric inversion on chromosome 3, inv(3), is rarely found in a normal population. The aim of our study was to investigate its possible link to hematologic malignancy. Chromosomes from bone marrow cells in 890 patients with hematologic disorders were analyzed with the Q-banding technique. Thirty-four patients had inv(3) (3.8%). In 241 patients with myelodysplastic syndromes the frequency was 6.2% as opposed to 2.9% in the remaining 649 patients (p=0.02). The increased frequency of inv(3) in patients with myelodysplastic syndromes indicates that inv(3) could be a risk factor for the development of the disease.
Gahrton
Caroline
C
Department of Medicine, Karolinska Institutet Huddinge, Stockholm, Sweden.
Nahi
Hareth
H
Jansson
Monika
M
Wallblom
Ann
A
Alici
Evren
E
Sutlu
Tolga
T
Samuelsson
Jan
J
Gahrton
Gösta
G
D002871:Chromosome Banding; D007446:Chromosome Inversion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D012307:Risk Factors