Right ventricle-sparing left ventricular resection and replacement with a continuous-flow rotary blood pump: an in vivo experiment.
Despite recent advances in left ventricular assist device and total artificial heart technologies, these devices are still so large that they pose a significant problem in small patients with refractory heart failure. Excising the left ventricle while preserving the right ventricle--and then replacing the left ventricle with a mechanical pump--has been proposed as an alternative approach to this problem. We conducted a pilot study to evaluate possible surgical techniques and the hemodynamic effects of right ventricle-sparing left ventricular resection and replacement with a continuous-flow rotary blood pump in a healthy bovine model.
Frazier
O H
OH
Cardiovascular Surgical Research Laboratories, Texas Heart Institute, St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. lschwenke@heart.thi.tmc.edu
Tuzun
Egemen
E
Narin
Cuneyt
C
Cohn
William E
WE
D000818:Animals; D006348:Cardiac Surgical Procedures / Q000295:instrumentation*; D002417:Cattle; D006352:Heart Ventricles / Q000503:physiopathology / Q000601:surgery*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008422:Materials Testing; D023421:Models, Animal; D010865:Pilot Projects; D011474:Prosthesis Design; D013997:Time Factors; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right