Traffic air pollution and oxidatively generated DNA damage: can urinary 8-oxo-7,8-dihydro-2-deoxiguanosine be considered a good biomarker? A meta-analysis.
Oxidative stress is one of the mechanisms through which traffic-related air pollution causes adverse effects on human health. The urinary excretion of 8-oxo-7,8-dihydro-2-deoxyguanosine (8oxodG) has often been used as a biomarker to evaluate the effect of air pollution on subjects occupationally exposed. We used a meta-analysis to evaluate the effect of traffic air pollution on urinary 8oxodG levels in healthy workers. We observed higher urinary 8oxodG levels in non-smoking exposed subjects compared with smokers. This difference was clearer when an HPLC assay was used. These results show that urinary 8oxodG can be used as a biomarker to evaluate the pro-oxidant effects of vehicle exhaust emissions on DNA in exposed workers.
Lettieri Barbato
Daniele
D
Food and Nutrition Unit, IRCCS San Raffaele Pisana, Rome, Italy.
Tomei
Gianfranco
G
Tomei
Francesco
F
Sancini
Angela
A
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000397:Air Pollution / Q000009:adverse effects*; D015415:Biomarkers / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D004249:DNA Damage; D003627:Data Interpretation, Statistical; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis; D012907:Smoking / Q000652:urine; D001335:Vehicle Emissions / Q000032:analysis*
D000395:Air Pollutants, Occupational; D015415:Biomarkers; D001335:Vehicle Emissions; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine