title: Recent advances in the study of candidate genes for adolescent idiopathic scoliosis.
abstract: We used a microarray approach to evaluate gene expression profiles in human AIS osteoblasts, and to identify genes that are differentially expressed following estrogen exposure in non-AIS and AIS human osteoblasts. We found that more than one gene is likely responsible for AIS. Furthermore, some of these genes are estrogen-regulated, suggesting a possible role of estrogens in the etiology of scoliosis.
authors.affiliation: CHU Sainte Justine and Université de Montréal, Montreal, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Fendri
authors.forename: S
authors.initials: S
authors.lastname: Patten
authors.forename: C
authors.initials: C
authors.lastname: Zaouter
authors.forename: S
authors.initials: S
authors.lastname: Parent
authors.forename: G
authors.initials: G
authors.lastname: Kaufman
authors.forename: H
authors.initials: H
authors.lastname: Labelle
authors.forename: P
authors.initials: P
authors.lastname: Edery
authors.forename: F
authors.initials: F
authors.lastname: Moldovan
mesh_terms: D000293:Adolescent; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D036281:Genetic Research; D006801:Humans; D012600:Scoliosis / Q000209:etiology / Q000235:genetics*