title: On the pulmonary toxicity of oxygen: III. The induction of oxygen dependency by oxygen use.
abstract: Oxygen is central to the development of neonatal lung injury. The increase in oxygen exposure of the neonatal lung during the onset of extrauterine air breathing is an order of magnitude, from a range of 10-12 to 110-120Torr. The contributions of oxygen and the volume and pressure relationships of ventilatory support to lung injury are not easily distinguished in the clinical setting. Sequential changes in inspired air or 100% oxygen were studied in 536 newborn rabbits without ventilatory support. Bilateral cervical vagotomies (BCV) were performed at 24h post natal to induce ventilatory distress which eventuates in hyaline membrane disease. The sequences applied yielded evidence for an induced state of oxygen dependency from oxygen use which was reflected in differences in survival and the extent of pulmonary injury. The median survival for animals kept in air throughout was 3h. Oxygen before vagotomy or during the first 3h afterwards extended the survival significantly but produced more extensive, more severe, and more rapid lung lesions. Returning animals to air after prior oxygen exposure reduced the number of survivors past 10h and shortened the maximum survival in those groups. These features indicate the development of a dependency of the defense mechanisms on the availability of oxygen at the higher level for metabolic and possibly other aspects of the pulmonary and systemic response to injury, beyond the usual physiological need. Subset analysis revealed additive and latent effects of oxygen and demonstrated a remarkable rapidity in onset of severe lesions under some circumstances, illustrating the toxicity of oxygen per se.
authors.affiliation: Marine Biological Laboratory, Woods Hole, MA 02543, USA. radfordcrawford@juno.com.
authors.forename: D Radford
authors.initials: DR
authors.lastname: Shanklin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004781:Environmental Exposure; D005260:Female; D055370:Lung Injury / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D010100:Oxygen / Q000378:metabolism / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D015656:Respiratory Mechanics; D015996:Survival Rate; D014628:Vagotomy
chemical_list: D010100:Oxygen