title: Progressive neurogenesis defines lateralis somatotopy.
abstract: Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.
authors.affiliation: Laboratory of Sensory Cell Biology and Organogenesis, Centre de Regulació Genòmica, Barcelona, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pujol-Martí
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Baudoin
authors.forename: Adèle
authors.initials: A
authors.lastname: Faucherre
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawakami
authors.forename: Hernán
authors.initials: H
authors.lastname: López-Schier
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D017950:Ganglia, Sensory / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000166:cytology / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics