An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy.
The cancer treatment by local hyperthermia, using a high frequency electromagnetic field is an extensively studied subject. For this propose it was developed a ferrimagnetic cement (FC) to be injected directly into the tumor. In this study it was determined the FC injectability, its capability to generate heat when placed within a magnetic field and its interaction with a modified simulated body fluid using SEM/EDS and XRD. The FC biological response was assessed by the intramuscular implantation in rats and histological analysis of the surrounding tissues. The results suggest that FC can be injected directly into the tumor, its temperature can be increased when exposed to a magnetic field and the surface of the immersed samples quickly becomes coated with precipitate denoting its ionic change with the surrounding medium. The histological analysis revealed a transient local inflammatory reaction, similar to the control material, only slightly more abundant during the first weeks, with a gradual decrease over the implantation time. Based on these results, we concluded that FC might be useful for highly focalized thermotherapy, with a good potential for clinical use.
Portela
Ana
A
Faculty of Dental Medicine, University of Porto, Porto, Portugal. a.isabelportela@gmail.com
Vasconcelos
Mário
M
Branco
Rogério
R
Gartner
Fátima
F
Faria
Miguel
M
Cavalheiro
José
J
D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology; D005899:Glass Ionomer Cements / Q000737:chemistry / Q000627:therapeutic use; D006358:Hot Temperature / Q000627:therapeutic use; D006979:Hyperthermia, Induced / Q000379:methods*; D066298:In Vitro Techniques; D007267:Injections; D015552:Injections, Intralesional; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar; D014961:X-Ray Diffraction
D001843:Bone Cements; D005290:Ferric Compounds; D005899:Glass Ionomer Cements