title: Replication of CLU, CR1, and PICALM associations with alzheimer disease.
abstract: OBJECTIVE
  To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease.
  
  
  METHODS
  Follow-up case-control association study.
  
  
  METHODS
  The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota.
  
  
  METHODS
  Community-based patients of European descent with late-onset Alzheimer disease (LOAD) and controls without dementia who were seen at the Mayo clinics, and autopsy-confirmed cases and controls whose pathology was evaluated at the Mayo Clinic in Jacksonville. Additional samples were obtained from the National Cell Repository for Alzheimer Disease (NCRAD). A total of 1829 LOAD cases and 2576 controls were analyzed.
  
  
  METHODS
  The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. Main Outcome Measure Clinical or pathology-confirmed diagnosis of LOAD.
  
  
  RESULTS
  Odds ratios for CLU, CR1, and PICALM were 0.82, 1.15, and 0.80, respectively, comparable in direction and magnitude with those originally reported. P values were 8.6 x 10(-5), .014, and 1.3 x 10(-5), respectively; they remain significant even after Bonferroni correction for the 3 single-nucleotide polymorphisms tested.
  
  
  CONCLUSIONS
  These results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD.
authors.affiliation: Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA.
authors.forename: Minerva M
authors.initials: MM
authors.lastname: Carrasquillo
authors.forename: Olivia
authors.initials: O
authors.lastname: Belbin
authors.forename: Talisha A
authors.initials: TA
authors.lastname: Hunter
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Gina D
authors.initials: GD
authors.lastname: Bisceglio
authors.forename: Fanggeng
authors.initials: F
authors.lastname: Zou
authors.forename: Julia E
authors.initials: JE
authors.lastname: Crook
authors.forename: V Shane
authors.initials: VS
authors.lastname: Pankratz
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Neill R
authors.initials: NR
authors.lastname: Graff-Radford
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Kevin
authors.initials: K
authors.lastname: Morgan
authors.forename: Steven G
authors.initials: SG
authors.lastname: Younkin
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D051152:Clusterin / Q000235:genetics*; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D034041:Monomeric Clathrin Assembly Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017463:Receptors, Complement 3b / Q000235:genetics*; D012111:Residence Characteristics; D044465:White People
chemical_list: C495242:CLU protein, human; C509991:CR1 protein, human; D051152:Clusterin; D034041:Monomeric Clathrin Assembly Proteins; C439003:PICALM protein, human; D017463:Receptors, Complement 3b