MicroRNA-134 plasma levels before and after treatment for bipolar mania.
Studies have previously documented that microRNAs (miRNAs), with their key roles in regulating both synaptic plasticity and brain development, are candidate genetic contributors to the etiopathology of bipolar disorder (BD). Moreover, miRNA identified as targets for the actions of chronic lithium and VPA are known to play diverse and intriguing roles in brain function. In particular, the brain specific miR-134 has recently been identified as a potential regulator of dendritic spine volume and synapse formation. Recently, circulating miRNAs have been reported as promising biomarkers for various pathologic conditions. We assessed the hypothesis that miRNA-134 may be present and detectable in circulating blood, and that miRNA-134 may serve as a biomarker of mania episodes in BD. In the present study, we recruited 21 bipolar I, manic (DSM-IV) patients and controls matched by sex and age for quantification of miR-134 level in plasma using real-time RT-PCR method. We found that: Plasma miR-134 levels in drug-free, 2-week medicated, and 4-week medicated bipolar mania patients were significantly decreased when compared with controls, and the level was increased on following medication. Decreased circulating miR-134 level both in drug-free and medicated patients did presented negative correlation with the clinical scales. Overall, these results suggest that the decreased plasma miR-134 levels may be directly associated with the pathophysiology and severity of manic symptoms in BD. Plasma miRNA-134 in BD may be considered as a potential peripheral marker that can respond to acute manic episodes and associate with effective mood stabilizers treatment.
Rong
Han
H
Department of Biology Psychiatry, Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Chuizhu Road 1080#, Shenzhen 518020, PR China.
Liu
Tie Bang
TB
Yang
Kong Jun
KJ
Yang
Hai Chen
HC
Wu
Dong Hui
DH
Liao
Chun Pin
CP
Hong
Fei
F
Yang
He Zen
HZ
Wan
Feng
F
Ye
Xiao Ying
XY
Xu
Dan
D
Zhang
Xuan
X
Chao
Chang An
CA
Shen
Qi Jie
QJ
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
D035683:MicroRNAs