title: Pathological complete remission of advanced hepatocellular carcinoma with main portal vein tumor thrombosis by hepatic arterial infusion chemotherapy.
abstract: Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m(2)) and cisplatin (25 mg/m(2)). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT.
authors.affiliation: Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
authors.forename: Yong Gil
authors.initials: YG
authors.lastname: Kim
authors.forename: Jong Ryul
authors.initials: JR
authors.lastname: Eun
authors.forename: Tae Nyeun
authors.initials: TN
authors.lastname: Kim
authors.forename: Heon Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jae Woon
authors.initials: JW
authors.lastname: Kim
authors.forename: Jay Chun
authors.initials: JC
authors.lastname: Chang
authors.forename: Sung Su
authors.initials: SS
authors.lastname: Yun
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Choi