title: Anxiety disorders in Chinese patients with Parkinson's disease.
abstract: OBJECTIVE
  Anxiety disorders (AND1) commonly occur in patients with Parkinson's disease (PD) but their socio-demographic and clinical correlates have not yet been unequivocally determined. This study aimed to assess the frequency of ANDI and their correlates in Chinese PD patients.
  
  
  METHODS
  A cohort of 133 patients of PD were recruited from three neurology outpatient clinics. Participants' neurological, cognitive, and psychiatric status was assessed using standardized rating instruments. ANDI were diagnosed by qualified psychiatrists using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders--4th Edition (SCID-DSM IV).
  
  
  RESULTS
  Thirty-six patients (27.1%) were diagnosed with some types of ANDI; Generalized Anxiety Disorder, Agoraphobia, and Social Phobia were the commonest subtypes of ANDI in PD (n = 11, 8.3%, in each of the three subtypes). Nine patients had more than one subtype of ANDI. In multivariate logistic regression, younger age of onset of PD [odds ratio (OR) = 2.654, 95% confident intervals (CI) = 1.120-6.289, p = 0.027), Geriatric Depression Scale score (OR = 1.179, 95% CI = 1.056-1.316, p = 0.003) and muscle cramps (> or = 1/week) (OR = 2.605, 95% CI = 1.098-6.184, p = 0.030) were independent correlates of ANDI.
  
  
  CONCLUSIONS
  ANDI are common in Chinese PD patients. Younger age of onset of PD, severity of depressive symptoms, and muscle cramps may be independent correlates of ANDI suggesting that anxiety in PD has multifactorial origin.
authors.affiliation: Chinese University of Hong Kong.
authors.forename: Yang-Kun
authors.initials: YK
authors.lastname: Chen
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Lu
authors.forename: D M L
authors.initials: DM
authors.lastname: Chan
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
authors.forename: M Au
authors.initials: MA
authors.lastname: Yeung
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
authors.forename: Gabor S
authors.initials: GS
authors.lastname: Ungvari
authors.forename: Wai Kwong
authors.initials: WK
authors.lastname: Tang
mesh_terms: D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology*; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000453:epidemiology*; D012307:Risk Factors