The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis.
Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap.
Buhimschi
Irina A
IA
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA. irina.buhimschi@yale.edu <irina.buhimschi@yale.edu>
Buhimschi
Catalin S
CS
D015415:Biomarkers / Q000032:analysis; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D023082:Defensins / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D017127:Glycation End Products, Advanced / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D040901:Proteomics / Q000379:methods*; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D015398:Signal Transduction
D015415:Biomarkers; D023082:Defensins; D017127:Glycation End Products, Advanced