title: Proinflammatory cytokines, hepatocyte growth factor and adipokines in peritoneal dialysis patients.
abstract: Chronic inflammation is a well-recognized complication in dialysis patients and a potential role of the adipose tissue as an important tissue of origin contributing to inflammation has been proposed. Stable peritoneal dialysis (PD) patients were enrolled to investigate the relationship between serum levels of proinflammatory cytokines and adipokines. Our results revealed that there was a strong association between high sensitivity C-reactive protein and interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) but not with IL-10 and IL-18. IL-6 correlated with TNF-alpha, IL-10, and IL-18. No association was found between IL-10 and IL-18. Adiponectin was positively correlated with all proinflammatory cytokines, except IL-10. No significant association was found between resistin and proinflammatory cytokines. Hepatocyte growth factor (HGF) was directly related to proinflammatory cytokines but not with adipokines. The presence of residual kidney function (RKF) affected IL-6, TNF-alpha, and HGF levels. The peritoneal transport property did not influence inflammatory cytokine and adipokine levels. In conclusion, there was a close relationship between proinflammatory cytokines and adipokines. HGF correlated with proinflammatory cytokines but not with adipokines. The PD-related factors such as RKF, peritoneal property and dialysis glucose load affected levels of proinflammatory cytokines. Body mass index was an important determinant of leptin and adiponectin in PD patients.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Chang-Gung Memorial Hospital Kaohsiung Medical Center, Chang-Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chien-Te
authors.initials: CT
authors.lastname: Lee
authors.forename: Hwee-Yeong
authors.initials: HY
authors.lastname: Ng
authors.forename: Chung-Yao
authors.initials: CY
authors.lastname: Hsu
authors.forename: Yu-Che
authors.initials: YC
authors.lastname: Tsai
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Yang
authors.forename: Te-Chuan
authors.initials: TC
authors.lastname: Chen
authors.forename: Terry Ting-Yu
authors.initials: TT
authors.lastname: Chiou
authors.forename: Chien-Chun
authors.initials: CC
authors.lastname: Kuo
authors.forename: Wen-Chin
authors.initials: WC
authors.lastname: Lee
authors.forename: Kao-Tai
authors.initials: KT
authors.lastname: Hsu
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001692:Biological Transport; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood*; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism
chemical_list: D054392:Adipokines; D016207:Cytokines; D017228:Hepatocyte Growth Factor