title: Spontaneous Formation of a Hydrogel Composed of Water-Soluble Phospholipid Polymers Grafted with Enantiomeric Oligo(lactic acid) Chains.
abstract: We designed and synthesized water-soluble biocompatible and biodegradable polymers composed of 2-methacryroyloxyethyl phosphorylcholine and oligo(L- or D-lactic acid) macromonomers to develop an injectable hydrogel matrix. Aqueous solutions containing the polymers with oligo(L-lactic acid) (OLLA) and oligo(D-lactic acid) (ODLA) chains underwent spontaneous gelation when mixed together. This was due to the formation of a stereocomplex between the OLLA and ODLA side-chains, which act as cross-linking components in the hydrogel. Therefore, the hydrogel could be re-dissolved in a buffer solution by hydrolysis of the oligo(lactic acid) chains. We obtained an injectable, biocompatible and degradable hydrogel, and we anticipate that it will be used in applications involving the controlled release of bioactive molecules and cell-based tissue engineering.
authors.affiliation: a Department of Bioengineering, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Center for Medical System Innovation, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Takami
authors.forename: Junji
authors.initials: J
authors.lastname: Watanabe
authors.forename: Madoka
authors.initials: M
authors.lastname: Takai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D055119:Elastic Modulus; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D019344:Lactic Acid / Q000737:chemistry; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D012996:Solutions; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D010743:Phospholipids; D011108:Polymers; D012996:Solutions; D014867:Water; D019344:Lactic Acid