Revascularization versus medical therapy for renal artery stenosis: antihypertensive drugs and renal outcome.
Endovascular procedures may play a role in renal artery stenosis (RAS) treatment in attempt to preserve renal function and improve hypertension control. We determined renal outcome and the incidence of restenosis in patients with RAS treated with renal percutaneous transluminal angioplasty and stenting (RPTAs) and medical therapy versus patients with RAS treated only with medical therapy. We performed an observational study based on 93 patients with RAS. In all, 53 patients underwent RPTAs in association with medical therapy and 40 patients were only treated pharmacologically. In patients receiving RPTAs, a better renal outcome, a decrease of restenosis rate, and systolic-diastolic blood pressure were associated with angiotensin receptor blockers (ARBs) + angiotensin-converting enzyme inhibitors (ACE-is) therapy. In patients treated with medical therapy alone, renal improvement was related to ARBs in association with BBs (β-blockers; P < .0001). This study suggests that medical therapy may exert beneficial effects in patients with RAS.
Cianci
Rosario
R
Department of Nephrology, Sapienza, University of Rome, Italy. ciancirosario@tin.it
Martina
Paola
P
Borghesi
Francesca
F
di Donato
Domenico
D
Polidori
Lelio
L
Lai
Silvia
S
Ascoli
Giada
G
de Francesco
Irene
I
Zaccaria
Alvaro
A
Gigante
Antonietta
A
Barbano
Biagio
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012078:Renal Artery Obstruction / Q000188:drug therapy / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
D000959:Antihypertensive Agents