Tensegrin in context: Dual role of α8 integrin in the migration of different cell types.
α8β1 integrin is highly expressed in cells with contractile function, such as mesangial cells of the kidneys and vascular smooth muscle cells (VSMCs). Although it promotes migration of neural crest cells and breast cancer cells, recent studies suggest that α8 integrin has a negative regulatory role in VSMC migration. In this review, the question of why α8β1 integrin plays a dual role in cell migration is raised and discussed. It seems that cells require optimum contractility and balanced tensile forces for migration. α8β1 integrin promotes migration of cells that are initially in a less than optimal contractile state (e.g. neural cells) and reduces the migration of cells known as contractile cells. α8β1 integrin can be called “Tensegrin” as it fits perfectly into the tensegrity model (tensional integrity) and seems to play a prominent role in the integration of the tensile forces.
Zargham
Ramin
R
McGill University, Experimental Medicine Department, Montreal, QC, Canada. ramin.zargham@mail.mcgill.ca
D000818:Animals; D000943:Antigens, Differentiation / Q000502:physiology*; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D016023:Integrins / Q000502:physiology*; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000502:physiology; D013314:Stress, Mechanical
D000943:Antigens, Differentiation; D016023:Integrins; C094866:integrin alpha8beta1