Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men.
The objective of this study was to investigate whether the mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modifies the effects of coffee consumption on serum lipid levels and the risk of dyslipidemia in middle-aged Japanese men. A total of 397 male subjects (age, 53.9±7.8 years; mean±s.d.) were selected from among individuals visiting the hospital for regular medical check-ups. After adjustment for age, body mass index, habitual alcohol consumption, habitual smoking and use of antihypertensive medication, among subjects who consumed <1 cup of coffee per day, the odds ratio (OR) for hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol > or =140 mg per 100 ml) was significantly lower in those with Mt5178A than in those with Mt5178C (OR=0.378, 95% confidence interval: 0.153-0.919). After adjustment, the association between the Mt5178A genotype and hyper-LDL cholesterolemia depended on coffee consumption (P for trend=0.018). Coffee consumption was positively associated with serum LDL cholesterol levels only in subjects with Mt5178A. However, in subjects with Mt5178C, serum LDL cholesterol level or risk of hyper-LDL cholesterolemia did not seem to depend on coffee consumption. These results suggest that for men with Mt5178A, coffee consumption negates the genetic benefit of lower risk for hyper-LDL cholesterolemia.
Kokaze
Akatsuki
A
Department of Public Health, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan. akokaze@med.showa-u.ac.jp
Ishikawa
Mamoru
M
Matsunaga
Naomi
N
Karita
Kanae
K
Yoshida
Masao
M
Shimada
Naoki
N
Ohtsu
Tadahiro
T
Shirasawa
Takako
T
Ochiai
Hirotaka
H
Kawamoto
Teruyoshi
T
Ito
Taku
T
Hoshino
Hiromi
H
Takashima
Yutaka
Y
D000225:Adenine / Q000737:chemistry; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D003069:Coffee; D003596:Cytosine / Q000737:chemistry; D004272:DNA, Mitochondrial; D005838:Genotype; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology / Q000235:genetics*; D007564:Japan; D008136:Longevity; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic
D008078:Cholesterol, LDL; D003069:Coffee; D004272:DNA, Mitochondrial; D003596:Cytosine; D000225:Adenine