title: 2,3-Disubstituted indoles via palladium-catalyzed reaction of 2-alkynyltrifluoroacetanilides with arenediazonium tetrafluoroborates.
abstract: A novel palladium-catalyzed synthesis of free N-H 2,3-disubstituted indoles from arenediazonium tetrafluoroborates and 2-alkynyltrifluoroacetanilides is presented. The reaction tolerates a variety of useful substituents both in the starting alkyne and the arenediazonium salt, including bromo and chloro substituents, nitro, cyano, keto, ester, and ether groups, as well as ortho substituents such as methoxy and methyl groups.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, La Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy. sandro.cacchi@uniroma1.it
authors.forename: Sandro
authors.initials: S
authors.lastname: Cacchi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Fabrizi
authors.forename: Antonella
authors.initials: A
authors.lastname: Goggiamani
authors.forename: Alcide
authors.initials: A
authors.lastname: Perboni
authors.forename: Alessio
authors.initials: A
authors.lastname: Sferrazza
authors.forename: Paolo
authors.initials: P
authors.lastname: Stabile
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D001881:Borates; D001888:Boric Acids / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry
chemical_list: D000083:Acetanilides; D001881:Borates; D001888:Boric Acids; D007211:Indoles; D011758:Pyrroles; D010165:Palladium; C098759:fluoroboric acid