title: [Hypothyroidism as the result of drug interaction between ferrous sulfate and levothyroxine].
abstract: We report a case of drug-drug interaction between ferrous sulfate and l-thyroxin. A 95-year-old woman treated successfully with l-thyroxin for many years received ferrous sulfate for anemia. This association led rapidly to recurrence of hypothyroidism with elevated serum than TSH level which completely resolved after withdrawal of iron therapy. Interaction was confirmed after both drugs were daily administrated separately without recurrence of hypothyroidism.
authors.affiliation: Service de médecine interne gériatrique, CHU de Rouen, 76031 Rouen cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Fiaux
authors.forename: K
authors.initials: K
authors.lastname: Kadri
authors.forename: C
authors.initials: C
authors.lastname: Levasseur
authors.forename: C
authors.initials: C
authors.lastname: Le Guillou
authors.forename: P
authors.initials: P
authors.lastname: Chassagne
mesh_terms: D000369:Aged, 80 and over; D004347:Drug Interactions; D005260:Female; D005296:Ferrous Compounds / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D013974:Thyroxine / Q000009:adverse effects*
chemical_list: D005296:Ferrous Compounds; C020748:ferrous sulfate; D013974:Thyroxine