The role of Nicorandil in non-healing surgical wounds.
We report two patients with non-healing surgical wounds, which healed after the withdrawal of Nicorandil therapy. Nicorandil should be recognised as an aetiological factor for non-healing wounds or ulcers once other inflammatory and malignant causes have been excluded. This may avoid surgery for high-risk patients and may also reduce complications for patients who undergo surgery for non-healing wounds. As Nicorandil is used in patients with severe coronary artery disease, it is recommended that the advice of a cardiologist is sought prior to cessation or adjustment to its dose.
Riddell
A D
AD
Department of General Surgery, Royal Free Hospital, London, UK. adriddell@hotmail.com
Minhas
U
U
Williams
G L
GL
Harding
K J
KJ
D000369:Aged, 80 and over; D003125:Colostomy; D005260:Female; D006484:Hemorrhoids / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D020108:Nicorandil / Q000009:adverse effects / Q000494:pharmacology*; D011183:Postoperative Complications / Q000139:chemically induced*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D014665:Vasodilator Agents; D020108:Nicorandil