title: Between-centre reproducibility of volumetric intravascular ultrasound radiofrequency-based analyses in mild-to-moderate coronary atherosclerosis: an international multicentre study.
abstract: To assess for the first time in a multicentre design the between-centre reproducibility of volumetric virtual histology intravascular ultrasound (VH-IVUS) measurements with a semi-automated, computerassisted contour detection system in mild-to-moderately diseased coronary segments.
  
  
  
  Analysts of four European IVUS centres performed independent IVUS analyses (in total 7,188 cross-sectional analyses) and obtained volumetric data to evaluate the reproducibility of volumetric VH-IVUS measurements in 36 coronary segments (length 20.0+/-0.4 mm) from patients with stable angina. Geometric and compositional VH-IVUS measurements were highly correlated for the different comparisons. Overall intraclass correlation for vessel, lumen, plaque volume and plaque burden were 0.98, 0.92 0.95, and 0.86, respectively; for fibrous, fibro-lipidic, necrotic core and calcified volumes overall intraclass correlations were 0.95, 0.93, 0.99, and 1.00, respectively. There were significant but small differences for vessel, lumen, fibrous and calcified volumes, and there was no significant difference for plaque volume. Of the plaque components necrotic core and calcified volume showed on average the highest reproducibility.
  
  
  
  These findings underline the necessity to centrally analyse IVUS data obtained in multicentre studies addressing mild-to-moderately diseased coronary arteries. In addition, pooling VH-IVUS data from different studies, analysed at different centres, may be problematical.
authors.affiliation: Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The Netherlands.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Huisman
authors.forename: Rasmus
authors.initials: R
authors.lastname: Egede
authors.forename: Adam
authors.initials: A
authors.lastname: Rdzanek
authors.forename: Dirk
authors.initials: D
authors.lastname: Böse
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.forename: Janusz
authors.initials: J
authors.lastname: Kochman
authors.forename: Lisette Okkels
authors.initials: LO
authors.lastname: Jensen
authors.forename: Job
authors.initials: J
authors.lastname: van de Palen
authors.forename: Marc
authors.initials: M
authors.lastname: Hartmann
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Clemens
authors.initials: C
authors.lastname: von Birgelen
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000209:etiology; D057205:Automation, Laboratory; D002118:Calcium / Q000032:analysis; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D003331:Coronary Vessels / Q000737:chemistry / Q000000981:diagnostic imaging*; D005060:Europe; D005260:Female; D005355:Fibrosis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008055:Lipids / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D015588:Observer Variation; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018084:Ultrasonography, Interventional
chemical_list: D008055:Lipids; D002118:Calcium