The paracrine effect: pivotal mechanism in cell-based cardiac repair.
Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvironment. The paracrine factors secreted by these cells represent a pivotal mechanism underlying the benefits of cell-mediated cardiac repair. This article reviews key studies behind the paracrine effect related to the cardiac reparative effects of cardiac cell therapy.
Maltais
Simon
S
Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, 5000 Belanger St. (East), Montréal, QC, Canada.
Tremblay
Jacques P
JP
Perrault
Louis P
LP
Ly
Hung Q
HQ
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D019899:Paracrine Communication; D012038:Regeneration; D033581:Stem Cell Transplantation; D016896:Treatment Outcome
D036341:Intercellular Signaling Peptides and Proteins