title: Caught in the act: in vivo development of macrolide resistance to Campylobacter jejuni infection.
abstract: We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistance in C. jejuni.
authors.affiliation: Vaccine Testing Center, University of Vermont College of Medicine, Department of Medicine, Burlington, VT 05405, USA. janet.lindow@uvm.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Lindow
authors.forename: F
authors.initials: F
authors.lastname: Poly
authors.forename: D R
authors.initials: DR
authors.lastname: Tribble
authors.forename: P
authors.initials: P
authors.lastname: Guerry
authors.forename: M P
authors.initials: MP
authors.lastname: Carmolli
authors.forename: S
authors.initials: S
authors.lastname: Baqar
authors.forename: C K
authors.initials: CK
authors.lastname: Porter
authors.forename: K K
authors.initials: KK
authors.lastname: Pierce
authors.forename: M J
authors.initials: MJ
authors.lastname: Darsley
authors.forename: K S
authors.initials: KS
authors.lastname: Sadigh
authors.forename: E A
authors.initials: EA
authors.lastname: Dill
authors.forename: B D
authors.initials: BD
authors.lastname: Kirkpatrick
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D015373:Bacterial Typing Techniques; D002169:Campylobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D064368:Healthy Volunteers; D006801:Humans; D018942:Macrolides / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D018942:Macrolides