title: Association of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism with advanced-stage endometriosis.
abstract: OBJECTIVE
  To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in a Korean population.
  
  
  METHODS
  Case-control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.
  
  
  RESULTS
  The distribution of the PPAR-γ2 Pro12Ala polymorphism was different between the advanced-stage endometriosis group and the control group (non-CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala-12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) (P = 0.006).
  
  
  CONCLUSIONS
  These findings suggest that the PPAR-γ2 Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala-12 allele may have protective effects against advanced-stage endometriosis in the Korean population.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
authors.forename: Kyu Ri
authors.initials: KR
authors.lastname: Hwang
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Jong Mee
authors.initials: JM
authors.lastname: Kim
authors.forename: Gyoung Hoon
authors.initials: GH
authors.lastname: Lee
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Chae
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004715:Endometriosis / Q000235:genetics* / Q000276:immunology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D047495:PPAR gamma / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D047495:PPAR gamma; D004247:DNA