title: Relationship between acquired deficiency of vitamin K-dependent clotting factors and hemorrhage.
abstract: This study examined the changes of activities of vitamin K-dependent clotting factors (VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage. Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed. Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects. The results showed that the average activities of VKDCFs were decreased in the patients in comparison to the control subjects and significantly increased after treatment of these patients with vitamin K and blood products. Multivariate regression analysis indicated that decreased activity of VKDCF was not an independent risk factor for bleeding disorders owing to deficiency or metabolic disturbance of vitamin K. It was concluded that acquired deficiency of VKDCF occurs under a variety of pathologic conditions and is closely associated with hemorrhagic events. Administration of vitamin K and transfusion of blood products containing high concentrations of VKDCFs helps alleviate the hemorrhagic diseases.
authors.affiliation: Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. mhz-yr@163.com
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.forename: Wenning
authors.initials: W
authors.lastname: Wei
authors.forename: Mei
authors.initials: M
authors.lastname: Hong
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood*; D001798:Blood Proteins / Q000172:deficiency*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006470:Hemorrhage / Q000097:blood*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014812:Vitamin K / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D014812:Vitamin K