title: Assessment of disease-free survival in patients with laryngeal squamous cell carcinoma treated with radiotherapy associated or not with chemotherapy.
abstract: In early stage (I and II) laryngeal squamous cell carcinoma, both surgery and radiotherapy results in significant local and regional control. In advanced tumors (III and IV), radiotherapy alone has local-regional control rates of 32-43%.
  
  
  OBJECTIVE
  To assess disease-free survival in SCC laryngeal carcinoma patients submitted to radiotherapy alone and/or associated with chemotherapy.
  
  
  METHODS
  Retrospective study involving 84 cases of laryngeal SCC treated with radiotherapy or chemotherapy together with radiotherapy. Fifty-three cases were treated with intension to cure and 31 because of impossibility to resect the disease. As to clinical stage (CS), 12 were CS I, 15 II, 21 III and 5 IV. In the second group, 11 cases were EC III and 20 IV.
  
  
  RESULTS
  Mean age was 60 years, 84.5% were men. Fifty-eight (69.1%) cases had complete response and 26 (30.9%) had persistent or residual disease. Five-year disease-free survival was of 42.5%; 62.5% of the patients with organ preservation indication and 9.75 in the group of irressecable disease.
  
  
  CONCLUSIONS
  Disease-free survival of those patients submitted to radiotherapy because of laryngeal SCC was of 62.5%.
authors.affiliation: Hospital Heliópolis (Heliopolis Hospital).
authors.forename: Helma Maria
authors.initials: HM
authors.lastname: Chedid
authors.forename: Carlos Neutzling
authors.initials: CN
authors.lastname: Lehn
authors.forename: Abrão
authors.initials: A
authors.lastname: Rapoport
authors.forename: Ali
authors.initials: A
authors.lastname: Amar
authors.forename: Sérgio Altino
authors.initials: SA
authors.lastname: Franzi
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies