title: Antibacterial sideroxylonals and loxophlebal A from Eucalyptus loxophleba foliage.
abstract: Loxophlebal A, a new antibacterial formylated phloroglucinol was isolated from the mother liquor obtained after separation of sideroxylonals from the chloroform-methanol extract of leaves of Eucalyptus loxophleba ssp lissophloia. The structure of loxophlebal A was determined to be 3-desformyl sideroxylonal A by spectroscopic methods including 1D- and 2D-NMR. The stereochemistry of loxophlebal A was determined by chemical correlation with sideroxylonal A. This article also reports an efficient, simple and economic method for large scale isolation of sideroxylonals in a purity of >90% from the leaves of Eucalyptus loxophleba ssp lissophloia.
authors.affiliation: Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab-160062, India.
authors.forename: Jasmeen
authors.initials: J
authors.lastname: Sidana
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Rohilla
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Roy
authors.forename: Russell A
authors.initials: RA
authors.lastname: Barrow
authors.forename: William J
authors.initials: WJ
authors.lastname: Foley
authors.forename: Inder Pal
authors.initials: IP
authors.lastname: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002845:Chromatography / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D005052:Eucalyptus / Q000737:chemistry*; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; D010936:Plant Extracts; C557379:loxophlebal A; D010696:Phloroglucinol