title: Prolonged survival of neoplastic meningitis from breast cancer with letrozole and intrathecal methotrexate: a case report.
abstract: Neoplastic meningitis from breast cancer has a dismal prognosis and short survival. Treatment is based on the intrathecal administration of chemotherapeutic agents, cranial or craniospinal radiotherapy, and systemic chemotherapy. In this report we describe the case of a woman with neoplastic meningitis from breast carcinoma who developed an excellent response to letrozole combined with intrathecal methotrexate, resulting in long-term survival of more than 36 months. Based on the findings of this case report, we suggest that addition of letrozole to the standard therapeutic approach may be beneficial for some patients.
authors.affiliation: Department of Medical Oncology, School of Medicine, University of Patras, 26504 Rio, Patras, Greece. panio@upatras.gr
authors.forename: Stavros
authors.initials: S
authors.lastname: Peroukides
authors.forename: Adimchi
authors.initials: A
authors.lastname: Onyenadum
authors.forename: Ioannis
authors.initials: I
authors.lastname: Starakis
authors.forename: Angelos
authors.initials: A
authors.lastname: Koutras
authors.forename: Thomas
authors.initials: T
authors.lastname: Makatsoris
authors.forename: George
authors.initials: G
authors.lastname: Bouboukas
authors.forename: Haralabos
authors.initials: H
authors.lastname: Kalofonos
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D000077289:Letrozole; D008581:Meningitis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009570:Nitriles / Q000008:administration & dosage; D011379:Prognosis; D015996:Survival Rate; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D008727:Methotrexate