Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.
PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically deleted it in postmitotic sensory neurons. Subsequent analyses reveal several interesting and surprising findings.
Zhou
Xiang
X
Department of Cell Biology, and Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Wang
Fan
F
D000818:Animals; D001343:Autophagy; D002462:Cell Membrane / Q000378:metabolism; D004789:Enzyme Activation; D017353:Gene Deletion; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010588:Phagosomes / Q000378:metabolism; D010641:Phenotype; D058539:Phosphatidylinositol 3-Kinase / Q000235:genetics*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000166:cytology* / Q000201:enzymology*
D008565:Membrane Proteins; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D058539:Phosphatidylinositol 3-Kinase