title: Takayasu arteritis in children and adolescents.
abstract: Takayasu arteritis is a devastating vasculitis of the aorta and its major branches. The clinical manifestations in paediatric patients are less specific than in adults: in children the disease presents with fever, arthralgias and hypertension. Intramural inflammation results in narrowing of the blood vessel lumen and therefore hypoperfusion of the parenchyma. Conventional angiography is the gold standard diagnostic procedure. Corticosteroids, cyclophosphamide, MTX and biological therapies such as TNF-α blocking agents are treatment options.
authors.affiliation: Department of Pediatrics, Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria. juergen.brunner@uki.at
authors.forename: Juergen
authors.initials: J
authors.lastname: Brunner
authors.forename: Brian M
authors.initials: BM
authors.lastname: Feldman
authors.forename: Pascal N
authors.initials: PN
authors.lastname: Tyrrell
authors.forename: Jasmin B
authors.initials: JB
authors.lastname: Kuemmerle-Deschner
authors.forename: Lothar B
authors.initials: LB
authors.lastname: Zimmerhackl
authors.forename: Ingmar
authors.initials: I
authors.lastname: Gassner
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Benseler
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D000792:Angiography / Q000379:methods; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D013625:Takayasu Arteritis / Q000188:drug therapy* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide