The giant protein titin as an integrator of myocyte signaling pathways.
The giant muscle protein titin, the "backbone" of the sarcomere, harbors a complex molecular spring whose stiffness is variably tuned in health and disease. Titin is increasingly recognized as a crucial integrator of diverse myocyte signaling pathways. The titin-associated signalosome includes hotspots of protein-protein interactions important for the regulation of protein quality-control mechanisms, hypertrophic gene activation, and mechanosensing.
Linke
Wolfgang A
WA
Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany. wolfgang.linke@rub.de
Krüger
Martina
M
D000818:Animals; D003094:Collagen / Q000502:physiology; D064211:Connectin; D004548:Elasticity / Q000502:physiology; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D009124:Muscle Proteins / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D064211:Connectin; D009124:Muscle Proteins; C577285:TTN protein, human; D003094:Collagen; D011494:Protein Kinases