Patients with Acinetobacter baumannii bloodstream infections are colonized in the gastrointestinal tract with identical strains.
In this study, we identified critically ill patients with Acinetobacter baumannii bacteremia and examined perirectal surveillance cultures for the presence of genetically related A baumannii strains using pulsed-field gel electrophoresis to determine whether gut colonization preceded clinical infection. Seven patients with imipenem-resistant A baumannii bacteremia were identified from January to June of 2008. Six of 7 (86%) patients were colonized in the gastrointestinal tract with genetically similar strains preceding their bacteremia.
Thom
Kerri A
KA
Division of Healthcare Outcomes Research, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 100 N. Greene Street, Baltimore, MD 21201, USA. kthom@epi.umaryland.edu
Hsiao
William W L
WW
Harris
Anthony D
AD
Stine
O Colin
OC
Rasko
David A
DA
Johnson
J Kristie
JK
D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D001769:Blood / Q000382:microbiology*; D016638:Critical Illness; D003428:Cross Infection / Q000382:microbiology; D016172:DNA Fingerprinting; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D015378:Imipenem