title: ACE inhibitors can induce circulating antibodies directed to antigens of the superficial epidermal cells.
abstract: Drug-induced pemphigus has been reported in patients receiving angiotensin-converting enzyme inhibitors. The aim of this work was to study a group of hypertensive patients without skin diseases treated with angiotensin-converting enzyme (ACE) Inhibitors (I), to verify the presence of serum circulating anti-antibodies. The indirect immunofluorescence showed that 33 sera (52.38%) presented autoantibodies directed to an antigen of the cytoplasm of the superficial epidermal keratinocytes. Two of the 33 positive sera had antibodies to Dsg1 and/or 3 in ELISA. Immunoblot analyses were negative. All the 48 control sera were found to have no circulating antibodies using the three assays. Our results would confirm that ACEI drugs may trigger the production of circulating autoantibodies also in patients without clinical manifestations of pemphigus.
authors.affiliation: Di.S.E.M. Section of Dermatology, University of Genoa, Viale Benedetto XV, Genoa, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cozzani
authors.forename: Gian Marco
authors.initials: GM
authors.lastname: Rosa
authors.forename: Massimo
authors.initials: M
authors.lastname: Drosera
authors.forename: Chiara
authors.initials: C
authors.lastname: Intra
authors.forename: Antonio
authors.initials: A
authors.lastname: Barsotti
authors.forename: Aurora
authors.initials: A
authors.lastname: Parodi
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D051183:Desmoglein 1 / Q000276:immunology; D051184:Desmoglein 3 / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D015151:Immunoblotting; D015603:Keratinocytes / Q000276:immunology*; D008297:Male; D010392:Pemphigus / Q000276:immunology; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001323:Autoantibodies; C495297:DSG1 protein, human; C071894:DSG3 protein, human; D051183:Desmoglein 1; D051184:Desmoglein 3