title: Decline of bone marrow-derived hematopoietic progenitor cell quality during aging in the rat.
abstract: Several studies have shown that aging is associated with quantitative and qualitative alterations of the stem and progenitor cell compartment. The current results indicate that there is a significant age-associated decline in the proliferative capacity of rat myeloid progenitor cells. In contrast, no difference was found in the frequency of myeloid progenitor cells in the bone marrow of young versus old rats. Furthermore, a significant shift towards higher proliferative capacity of myeloid progenitors was observed after lifelong voluntary exercise. These data emphasize that aging is accompanied by a loss of proliferative capacity and that voluntary exercise could retard this process.
authors.affiliation: Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Stelzer
authors.forename: Robert
authors.initials: R
authors.lastname: Fuchs
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schraml
authors.forename: Ping
authors.initials: P
authors.lastname: Quan
authors.forename: Michaela
authors.initials: M
authors.lastname: Hansalik
authors.forename: Peter
authors.initials: P
authors.lastname: Pietschmann
authors.forename: Franz
authors.initials: F
authors.lastname: Quehenberger
authors.forename: Monika
authors.initials: M
authors.lastname: Skalicky
authors.forename: Andrus
authors.initials: A
authors.lastname: Viidik
authors.forename: Konrad
authors.initials: K
authors.lastname: Schauenstein
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D002452:Cell Count; D049109:Cell Proliferation; D002469:Cell Separation; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D023461:Myeloid Progenitor Cells / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor