title: Integrins and signal transduction.
abstract: Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines.
authors.affiliation: Molecular and Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Torino, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Cabodi
authors.forename: Paola
authors.initials: P
authors.lastname: Di Stefano
authors.forename: Maria del Pilar Camacho
authors.initials: Mdel P
authors.lastname: Leal
authors.forename: Agata
authors.initials: A
authors.lastname: Tinnirello
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bisaro
authors.forename: Virginia
authors.initials: V
authors.lastname: Morello
authors.forename: Laura
authors.initials: L
authors.lastname: Damiano
authors.forename: Simona
authors.initials: S
authors.lastname: Aramu
authors.forename: Daniele
authors.initials: D
authors.lastname: Repetto
authors.forename: Giusy
authors.initials: G
authors.lastname: Tornillo
authors.forename: Paola
authors.initials: P
authors.lastname: Defilippi
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D000199:Actins; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D018121:Receptors, Cytokine; D051416:Focal Adhesion Protein-Tyrosine Kinases; D019061:src-Family Kinases