Relationship between serum levels of superoxide dismutase activity and subsequent risk of lung cancer mortality: Findings from a nested case-control study within the Japan Collaborative Cohort Study.
The expression of superoxide dismutases (SODs) has been shown to differ between lung tumor and tumor-free tissues. In the present study, we investigated the association between serum SOD activity and the risk of lung cancer mortality, based on a nested case-control design study within the Japan Collaborative Cohort Study, with a sample of 193 lung cancer patients and 573 matched controls. Blood samples were obtained at the baseline and stored at -80 degrees C until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for lung cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% CIs for the second, third; and fourth SOD quartiles were 0.80 (95%CI: 0.49-1.29), 1.32 (0.78-2.25), and 1.07 (0.60-1.89), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.56 (95%CI: 0.30-1.07), 1.16 ( 0.57-2.37), and 1.11 (0.52-2.35) for the period from the baseline to 1994; and the adjusted ORs of 1.36 (95%CI: 0.65-2.85), 1.71 (0.75-3.87), and 1.06 (0.44-2.53) for the period after 1994. To conclude, we found no significant association between serum SOD level and the risk of deaths from lung cancer in the present study.
Pham
Truong-Minh
TM
Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Japan. ptrminh@med.uoeh-u.ac.jp
Fujino
Yoshihisa
Y
Ando
Masahiko
M
Suzuki
Koji
K
Nakachi
Kei
K
Ito
Yoshinori
Y
Watanabe
Yoshiyuki
Y
Inaba
Yutaka
Y
Tajima
Kazuo
K
Tamakoshi
Akiko
A
Yoshimura
Takesumi
T
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood*; D000072105:Superoxide Dismutase-1; D015996:Survival Rate
D015415:Biomarkers; C000606290:SOD1 protein, human; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1