Biotransformation of ent-kaur-16-en-19-oic acid by Absidia blakesleeana and Rhizopus oligosporus.
Biotransformation of ent-kaur-16-en-19-oic acid was carried out with Absidia blakesleeana and Rhizopus oligosporus. Absidia blakesleeana produced two novel metabolites, ent-(7alpha, 9alpha)-dihydroxy-kaur-16-en-19-oic acid and ent-(1beta, 7alpha)-dihydroxy-kaur-16-en-19-oic acid, together with three known compounds: ent-7alpha-hydroxy-kaur-16-en-19-oic acid, ent-(7alpha, 11beta)-dihydroxy-kaur-16-en-19-oic acid and ent-(7alpha, 13)-dihydroxy-kaur-16-en-19-oic acid. The ent-7alpha-hydroxy-kaur-16-en-19-oic acid and ent-(7alpha, 9alpha)-dihydroxy-kaur-16-en-19-oic acid were obtained from R. oligosporus. The structures were established by spectroscopic techniques and X-ray crystallography.
Taveepanich
Somjintana
S
Department of Chemistry, Faculty of Science, Research Centre for Bioorganic Chemistry, Chulalongkorn University, Bangkok, Thailand.
Muangsin
Nongnuj
N
Saithong
Saowanit
S
Pakawatchai
Chawang
C
Chaichit
Narongsak
N
Roengsumran
Sophon
S
Petsom
Amorn
A
D020095:Absidia / Q000737:chemistry / Q000378:metabolism*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012233:Rhizopus / Q000737:chemistry / Q000378:metabolism*
D004224:Diterpenes; C014341:argyrophilic acid