title: [Taste sensitivity diminution in hyperglycemic type 2 diabetics patients].
abstract: OBJECTIVE
  To determine the relationship between fasting blood glucose (FBG) values and gustatory sensitivity alterations in type 2 diabetic patients (DM2) without peripheral neuropathy (PNP).
  
  
  METHODS
  Assessment of the strength of association between FBG and detection and recognition taste thresholds for the four primary tastes measured by chemical gustometry were performed in 140 DM2 without PNP with evolution < 10 years.
  
  
  RESULTS
  FBG values above 7.77 mmol/L (140 mg/dL) induce in a dependent manner, the increase in the detection and recognition taste thresholds only to sweetness; whereas, values above 16.65 mmol/L (300 mg/dL) did not cause further decreasing in taste acuity to sweet flavor. Statistically significant differences where found for detection and recognition, taste thresholds for sucrose between well controlled (HbA1c < or = 7 %) normoglycemic and hyperglycemic diabetics, as well as between alarming uncontrolled (HbA1c > 10 %) normoglycemic and hyperglycemic patients.
  
  
  CONCLUSIONS
  Hyperglycemia induces a concentration-dependent impairment of sweet taste perception in DM2 patients as the result of an adaptation of the sensory cell to elevated circulating concentrations of glucose.
authors.affiliation: Hospital General de Zona con Unidad de Medicina Familiar 9, Ciudad Guzmán, Jalisco, México. rafaelb@cusur.udg.mx
authors.forename: Rafael
authors.initials: R
authors.lastname: Bustos-Saldaña
authors.forename: Martín
authors.initials: M
authors.lastname: Alfaro-Rodríguez
authors.forename: María de la Luz
authors.initials: Mde L
authors.lastname: Solís-Ruiz
authors.forename: Benjamín
authors.initials: B
authors.lastname: Trujillo-Hernández
authors.forename: Mauro
authors.initials: M
authors.lastname: Pacheco-Carrasco
authors.forename: Clemente
authors.initials: C
authors.lastname: Vázquez-Jiménez
authors.forename: Alfredo de Jesús
authors.initials: Ade J
authors.lastname: Celis-de la Rosa
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013651:Taste Disorders / Q000453:epidemiology / Q000209:etiology*