Serum soluble fas levels and superoxide dismutase activity and the risk of death from pancreatic cancer: A nested case-control study within the Japanese Collaborative Cohort Study.
In a search for novel circulating biomarkers for pancreatic cancer, we examined the association between serum soluble Fas (sFas) levels and superoxide dismutase (SOD) activity and the risk of death from pancreatic cancer in a nested case-control study within the Japanese Collaborative Cohort Study. Case subjects were 68 persons who were free of morbidity, had provided a blood sample at baseline (1988-1990), and subsequently died from pancreatic cancer before December 31, 1997. Control subjects were 199 matched persons who were selected from the remaining participants in the cohort. Conditional logistic regression models were used to estimate age-adjusted and multivariate-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). No statistically significant differences were noted in mean sFas levels (p=0.11) and SOD activity (p=0.42) between cases and controls. Overall, neither serum sFas levels nor SOD activity were associated with the risk of pancreatic cancer deaths, after adjustment for area, BMI, cigarette smoking, and history of diabetes. Furthermore, no significant risk trends were noted. Our results do not support the hypothesis that serum sFas levels and SOD activity are associated with pancreatic cancer risk.
Lin
Yingsong
Y
Department of Public Health, Aichi Medical University School of Medicine, Japan. linys@aichi-med-u.ac.jp
Kikuchi
Shogo
S
Yagyu
Kiyoko
K
Ishibashi
Teruo
T
Kurosawa
Michiko
M
Ito
Yoshinori
Y
Watanabe
Yoshiyuki
Y
Inaba
Yutaka
Y
Tajima
Kazuo
K
Nakachi
Kei
K
Tamakoshi
Akiko
A
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D011379:Prognosis; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood*; D000072105:Superoxide Dismutase-1; D015996:Survival Rate; D019014:fas Receptor / Q000097:blood*
D015415:Biomarkers; C491901:FAS protein, human; C000606290:SOD1 protein, human; D019014:fas Receptor; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1