title: MicroRNA-134 plasma levels before and after treatment for bipolar mania.
abstract: Studies have previously documented that microRNAs (miRNAs), with their key roles in regulating both synaptic plasticity and brain development, are candidate genetic contributors to the etiopathology of bipolar disorder (BD). Moreover, miRNA identified as targets for the actions of chronic lithium and VPA are known to play diverse and intriguing roles in brain function. In particular, the brain specific miR-134 has recently been identified as a potential regulator of dendritic spine volume and synapse formation. Recently, circulating miRNAs have been reported as promising biomarkers for various pathologic conditions. We assessed the hypothesis that miRNA-134 may be present and detectable in circulating blood, and that miRNA-134 may serve as a biomarker of mania episodes in BD. In the present study, we recruited 21 bipolar I, manic (DSM-IV) patients and controls matched by sex and age for quantification of miR-134 level in plasma using real-time RT-PCR method. We found that: Plasma miR-134 levels in drug-free, 2-week medicated, and 4-week medicated bipolar mania patients were significantly decreased when compared with controls, and the level was increased on following medication. Decreased circulating miR-134 level both in drug-free and medicated patients did presented negative correlation with the clinical scales. Overall, these results suggest that the decreased plasma miR-134 levels may be directly associated with the pathophysiology and severity of manic symptoms in BD. Plasma miRNA-134 in BD may be considered as a potential peripheral marker that can respond to acute manic episodes and associate with effective mood stabilizers treatment.
authors.affiliation: Department of Biology Psychiatry, Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Chuizhu Road 1080#, Shenzhen 518020, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Rong
authors.forename: Tie Bang
authors.initials: TB
authors.lastname: Liu
authors.forename: Kong Jun
authors.initials: KJ
authors.lastname: Yang
authors.forename: Hai Chen
authors.initials: HC
authors.lastname: Yang
authors.forename: Dong Hui
authors.initials: DH
authors.lastname: Wu
authors.forename: Chun Pin
authors.initials: CP
authors.lastname: Liao
authors.forename: Fei
authors.initials: F
authors.lastname: Hong
authors.forename: He Zen
authors.initials: HZ
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Wan
authors.forename: Xiao Ying
authors.initials: XY
authors.lastname: Ye
authors.forename: Dan
authors.initials: D
authors.lastname: Xu
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Chang An
authors.initials: CA
authors.lastname: Chao
authors.forename: Qi Jie
authors.initials: QJ
authors.lastname: Shen
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
chemical_list: D035683:MicroRNAs