Genotoxic effects caused by indoor exposure to petroleum derivatives in a fuel quality control laboratory.
We looked for genotoxic effects in laboratory personnel routinely exposed to petroleum derivate compounds in an indoor environment. The exposed group of 21 workers from the Fuel Quality Control Laboratory of the Brazilian Petroleum Agency was matched with a group of 10 people from the staff of the Brazilian Ministry of Health. Chromosome aberrations in peripheral blood lymphocytes, micronuclei in exfoliated cells in the urine and hematological parameters were examined. There was a significantly increased level of chromosome aberrations and micronuclei in the exposed group compared with controls. A high correlation between chromosome aberrations and micronuclei was observed in the exposed group (Spearman rank test, r = 0.73, P = 0.0001). The hematological parameters in these exposed individuals did not differ from reference values.
Araújo
A E O
AE
Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brasil.
Mezzomo
B P
BP
Ferrari
I
I
Grisolia
C K
CK
D000328:Adult; D001938:Brazil; D002869:Chromosome Aberrations; D004249:DNA Damage; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D015162:Micronucleus Tests; D009153:Mutagens; D016273:Occupational Exposure; D010578:Petroleum / Q000009:adverse effects / Q000633:toxicity*; D011786:Quality Control; D012016:Reference Values; D001743:Urinary Bladder / Q000378:metabolism
D009153:Mutagens; D010578:Petroleum