Ophiocerol, a novel macrocylic neolignan from the aquatic fungus Ophioceras dolichostomum YMF1.00988.
From cultural filtrates of the freshwater fungus Ophioceras dolichostomum YMF1.00988 a novel neolignan with an unprecedented dibenzo-1,6-dioxacyclodecane carbon skeleton, ophiocerol (1), was isolated, and the known compounds isoamericanoic acid A (2) and caffeic acid (3) were identified. The structure of the novel compound was determined by interpretation of its spectroscopic data, including 1D and 2D, (1)H and (13)C NMR (COSY, HMQC, HMBC, NOESY), and MS. Compounds 1-3 were assayed for their nematicidal activity against Bursaphelenchus xylophilus as well as their antifungal activity against several plant pathogen fungi.
Dong
Jin-Yan
JY
Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming, P.R. China.
Wang
Le
L
Song
Hong-Chuang
HC
Wang
Li-Mei
LM
Shen
Kai-Ze
KZ
Sun
Rong
R
Li
Guo-Hong
GH
Li
Lei
L
Zhang
Ke-Qin
KQ
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000969:Antinematodal Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017187:Tylenchida / Q000187:drug effects
D000935:Antifungal Agents; D000969:Antinematodal Agents; D017705:Lignans