title: Repeated Paradoxical Aggravation of Preexisting Psoriasis during Infliximab Treatment for Crohn's Disease.
abstract: As more rheumatologists and dermatologists have begun to use biological agents such as TNF-alpha blocker, they have confronted an unexpected complication: psoriasis was paradoxically aggravated or induced by the TNF-alpha blocker. Although it is not a common complication of TNF-alpha blocker, this aggravation may be more common than previously thought. To our knowledge, most reports about TNF-alpha blocker-induced psoriasis have been limited to western countries while only a few cases have been reported in Korea and Japan. In addition, new onset of pustular psoriasis by TNF-alpha blocker has been reported more commonly than worsening of preexisting psoriasis. Now we report a patient whose preexisting psoriasis vulgaris was aggravated repeatedly after using the TNF-alpha blocker, infliximab, to control Crohn's disease, which is a rare rheumatologic disease in Korea.
authors.affiliation: Department of Dermatology, Ajou University Hospital, Suwon, Korea.
authors.forename: Byung Cheol
authors.initials: BC
authors.lastname: Park
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Lim
authors.forename: Byung Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Weon Ju
authors.initials: WJ
authors.lastname: Lee
authors.forename: Do Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Seok-Jong
authors.initials: SJ
authors.lastname: Lee