Evaluation on the pathogenicity of Erysipelothrix tonsillarum for pigs by immunosuppression with cyclophosphamide or dexamethasone.
The pathogenicity of Erysipelothrix tonsillarum was evaluated in pigs immunosuppressed with cyclophosphamide (CY) or dexamethasone (DM). Animals were treated with 15 mg/kg CY (n=8, five injections), 1 mg/kg DM (n=8, nine injections) or left untreated (n=8). On the fifth day after the beginning of drug treatments, swine were inoculated with one of two E. tonsillarum serovar 7 strains (approximately 10(6) CFU per pig). In the CY-treated group, both circulating neutrophil and lymphocyte counts decreased, whereas in the DM-treated group, lymphocyte counts decreased but neutrophil counts increased. During the observation period, none of the CY- or DM-treated pigs developed clinical signs or gross lesions, as well as non-treated pigs. Growth agglutination antibody titres in all pigs remained unchanged. Our findings indicate that E. tonsillarum strains are avirulent for swine, regardless of immune status.
Harada
Kazuki
K
National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan. k-harada@nvlu.ac.jp
Muramatsu
Masatake
M
Suzuki
Shoko
S
Tamura
Yutaka
Y
Sawada
Takuo
T
Takahashi
Toshio
T
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D003520:Cyclophosphamide / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004888:Erysipelothrix / Q000145:classification / Q000472:pathogenicity*; D004889:Erysipelothrix Infections / Q000276:immunology / Q000382:microbiology*; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000494:pharmacology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology*
D000907:Antibodies, Bacterial; D007166:Immunosuppressive Agents; D003907:Dexamethasone; D003520:Cyclophosphamide