title: Delay in thrombolysis of massive and submassive pulmonary embolism.
abstract: OBJECTIVE
  To report the time of delay in thrombolysis of massive and submassive pulmonary embolism (PE).
  
  
  METHODS
  We enrolled 83 consecutive patients with massive and submassive PE from 8 hospitals between June 2006 and March 2009. We recorded the delay between symptom onset and thrombolysis. The clinical findings related to early thrombolysis (delay ≤ 2 days) were analyzed.
  
  
  RESULTS
  Median of the delay in thrombolysis was 8 days with 82% over 2 days, 53% over 7 days, and 6% over 25 days. Compared to the late thrombolysis (delay >2 days), patients with early thrombolysis more frequently had murmurs at the tricuspid area (26.7% vs 6.1%, P = .053), less frequently had cough (20% vs 59.7%, P = .005) and increased P2 (pulmonic component of second heart sound; 33.3% vs 61.2%, P = .049), and more patients were thrombolysed in off-hours (86.7% vs 57.4%, P = .034).
  
  
  CONCLUSIONS
  The time of delay in thrombolysis is too long and the symptoms and signs between early and late thrombolysis groups may differ.
authors.affiliation: Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Ma
authors.forename: Chen
authors.initials: C
authors.lastname: Qiu
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Hu
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Zhai
authors.forename: Wanmu
authors.initials: W
authors.lastname: Xie
authors.forename: Changting
authors.initials: C
authors.lastname: Liu
mesh_terms: D000368:Aged; D000818:Animals; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents