Platelet-derived microparticles are removed by a membrane plasma separator.
Platelet-derived microparticles (PDMPs) are released from activated platelets and are closely related to various diseases. Using the enzyme-linked immunosorbent assay, PDMP concentrations in blood and separated plasma of eight patients who underwent apheresis using membrane plasma separator at our hospital were tested. Considerable amounts of PDMPs were filtrated using plasma separators. However, the concentrations of PDMPs within the blood at the end of the therapy did not differ significantly from those before the session. Plasmapheresis itself might have activated platelets to release PDMPs or perhaps PDMPs within the supplementary fluid increased PDMPs during the therapy. After resolving these points, plasmapheresis could become an effective therapy against elevated PDMP conditions.
Hanafusa
Norio
N
Departments of Hemodialysis and Apheresis, The University of Tokyo Hospital, Japan. hanafusa-tky@umin.ac.jp
Satonaka
Hiroshi
H
Doi
Kent
K
Yatomi
Yutaka
Y
Noiri
Eisei
E
Fujita
Toshiro
T
D000328:Adult; D000368:Aged; D001792:Blood Platelets; D055252:Cell-Derived Microparticles; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000295:instrumentation*