An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial.
BACKGROUND
Hibiscus sabdariffa is used regularly in folk medicine to treat various conditions.


METHODS
The study was a double blind, placebo controlled, randomized trial. Sixty subjects with serum LDL values in the range of 130-190 mg/dl and with no history of coronary heart disease were randomized into experimental and placebo groups. The experimental group received 1 gm of the extract for 90 days while the placebo received a similar amount of maltodextrin in addition to dietary and physical activity advice for the control of their blood lipids. Anthropometry, blood biochemistry, dietary and physical activity were assessed at baseline, day 45 and day 90.


RESULTS
While body weight, serum LDL cholesterol and triglyceride levels decreased in both groups, there were no significant differences between the experimental and placebo group.


CONCLUSIONS
It is likely that the observed effects were as a result of the patients following the standard dietary and physical activity advice. At a dose of 1 gm/day, hibiscus sabdariffa leaf extract did not appear to have a blood lipid lowering effect.


BACKGROUND
REFCTRI2009000472.
Kuriyan
Rebecca
R
Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore 560034, India. rebecca@sjri.res.in
Kumar
Divya R
DR
R
Rajendran
R
Kurpad
Anura V
AV
D000328:Adult; D001835:Body Weight / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood*; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D031584:Hibiscus; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007194:India; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D011134:Polysaccharides; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; D014280:Triglycerides; C008315:maltodextrin