title: Successful prevention of thrombotic thrombocytopenic purpura (TTP) relapse using monthly prophylactic plasma exchanges throughout pregnancy in a patient with systemic lupus erythematosus and a prior history of refractory TTP and recurrent fetal loss.
abstract: BACKGROUND
  The occurrence of thrombotic thrombocytopenic purpura (TTP) in the setting systemic lupus erythematosus (SLE) is rare. In women of childbearing age, TTP is associated with high rates of recurrence in pregnancy. Furthermore, both TTP and SLE are associated with a significant risk of adverse pregnancy outcomes.
  
  
  METHODS
  We describe the case of a 36 year old female in her first trimester of pregnancy with a prior history of SLE-associated severe refractory TTP who was treated with a combination of corticosteroids and prophylactic plasma exchanges (PLEX) throughout pregnancy to prevent TTP recurrence. She delivered a healthy infant at 33 weeks of gestation after the onset of preterm labor. There was no evidence of TTP recurrence in the antepartum or postpartum period in this high risk patient.
  
  
  CONCLUSIONS
  Prophylactic PLEX should be considered as a therapeutic option to prevent recurrent TTP during pregnancy in high risk patients, including patients with previous SLE-associated TTP.
authors.affiliation: Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Karim
authors.initials: K
authors.lastname: Abou-Nassar
authors.forename: Jacob
authors.initials: J
authors.lastname: Karsh
authors.forename: Antonio
authors.initials: A
authors.lastname: Giulivi
authors.forename: David
authors.initials: D
authors.lastname: Allan
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000628:therapy; D010951:Plasma Exchange; D010956:Plasmapheresis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000517:prevention & control*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000188:drug therapy / Q000517:prevention & control*