Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs.
Single photon emission computed tomography (SPECT) with the cocaine-analogue [(123)I]-FP-CIT is widely used for in vivo assessment of the dopamine transporter (DAT) availability. Dopaminergic disturbance has been implicated in neurological and behavioural disorders in humans and animals. Ten healthy dogs were scanned at three different time points (between 3 h and 6 h post-tracer injection) under general anaesthesia (1.4% isoflurane). A pseudo-equilibral state was reached 3-6 h after tracer injection with normal reference values for the DAT binding indices (mean±SD) of 15.39±2.38 (left) and 15.23±2.23 (right). By determining the pseudo-equilibrium and the normal DAT binding indices of normally behaving dogs, this study paves the way for future research on the relationship between abnormal canine behaviour and a disturbed dopaminergic system.
Vermeire
Simon
S
Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium. simon.vermeire@ugent.be
Audenaert
Kurt
K
Vandermeulen
Eva
E
Waelbers
Tim
T
De Spiegeleer
Bart
B
van Bree
Henri
H
Peremans
Kathelijne
K
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D004285:Dogs; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D008297:Male; D011485:Protein Binding; D019275:Radiopharmaceuticals / Q000378:metabolism*; D012016:Reference Values; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000662:veterinary*; D014326:Tropanes / Q000378:metabolism*
D050483:Dopamine Plasma Membrane Transport Proteins; D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane