[Critical bone defects elimination by bioengineering construction upon non-resorbable polymeric base with the use of autogenic multipotent stromal cells from adipose tissue].
On 8 rabbits with experimentally produced critical defects of calvarium plastics of the defects was performed by bioengineering constructions based upon porous polytetrafluoroethylene with multifunctional nanostructured non-resorbable cover Ti-C-Ca-P-O-N and autogenic stromal cells from adipose tissue (the main group -4 rabbits). In the reference group (4 rabbits) the defects were repaired by abiologic implants. At the terms of 3 and 6 months in the main group under implants the formation of the full value bone regenerate was seen in the region of calvarium defects. In the reference group in the bone defects the regenerate from rough fibrose connective tissue was formed.
Kulakov
A A
AA
Grigor'ian
A S
AS
Kiselev
E V
EV
Khamraev
T K
TK
Filonov
M R
MR
Gatiev
A B
AB
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D057005:Bioengineering; D001861:Bone Regeneration; D002469:Cell Separation; D039902:Multipotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D049329:Nanostructures / Q000737:chemistry; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D011817:Rabbits; D012886:Skull / Q000293:injuries / Q000502:physiology / Q000601:surgery*; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation*; D023822:Tissue Engineering / Q000379:methods*
D011138:Polytetrafluoroethylene