Protective effects of propofol on peritoneal adhesions in cecal ligation and puncture model.
OBJECTIVE
We assumed that one of the most widely used anesthetic agents, propofol, which is the most widely used anesthetic for sedation, may reduce inflammatory processes and organ injury induced by cecal ligation and puncture.


METHODS
Bacterial peritonitis was induced in 18 rats by cecal ligation and puncture. The rats were randomly assigned to three groups. Group 1 (n=6) received propofol, group 2 (n=6) received intralipid, group 3 (n=6) was a control group, which did not receive any injection. All animals were killed 14 days later so we could assess the adhesion score. Tissue antioxidant levels were measured in 1-g tissue samples taken from the abdominal wall.


RESULTS
The adhesion score was significantly lower in the propofol group than in the control group (p<0.05). The catalase levels were higher in the intralipid and control groups than the propofol groups.


CONCLUSIONS
Intraperitoneal propofol reduced the formation of postoperative intra-abdominal adhesions without compromising wound healing in this bacterial peritonitis rat model. Propofol also decreased the oxidative stress during peritonitis (Tab. 1, Fig. 5, Ref. 28). Full Text (Free, PDF) www.bmj.sk.
Aykas
Ahmet
A
Department of General Surgery and Organ Transplantation, and Research Center, Izmir Teaching Hospital, Ministry of Health, Izmir, Turkey.
Yuzbasioglu
Mehmet Fatih
MF
Kurutas
Ergul Belge
EB
Nart
Ahmet
A
Demirtas
Ozgur
O
Dogan
Murat
M
Oksuz
Hafize
H
Simsek
Cenk
C
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D007416:Intestinal Perforation / Q000150:complications*; D010532:Peritoneal Diseases / Q000473:pathology / Q000517:prevention & control*; D010538:Peritonitis / Q000473:pathology / Q000503:physiopathology; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
D018686:Anesthetics, Intravenous; D015742:Propofol