Two-way traffic on the bridge from innate to adaptive immunity.
Conventional wisdom suggests that information is usually transmitted from the dendritic cell (DC) to the T cell. In this issue, Schwarz and Schwarz demonstrate that UV-induced T regulatory cells (Tregs) can influence the biology of naïve DC. They report that IL-10-secreting Tregs prime DC to activate additional Tregs when injected into naïve mice. It may be possible to use DCs that have been "educated" by Tregs to induce immune tolerance in vivo.
Ullrich
Stephen E
SE
Department of Immunology and the Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. sullrich@mdanderson.org
D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice; D012867:Skin / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*