title: Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.
abstract: We report the efficient synthesis and biological evaluation of new benzodioxinoindolocarbazoles heterocycles (BDCZs) designed as potential anticancer agents. Indolic substitution and maleimide variations were performed to design a new library of BDCZs and their cytotoxicity were evaluated on two representative cancer cell lines. Several derivatives have shown a marked cytotoxicity with IC(50) values in the nanomolar range. Results are reported in this Letter.
authors.affiliation: Institut de Chimie Organique et Analytique, UMC CNRS 6005, Orléans cedex 2, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ayerbe
authors.forename: Sylvain
authors.initials: S
authors.lastname: Routier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gillaizeau
authors.forename: Carmen
authors.initials: C
authors.lastname: Maiereanu
authors.forename: Daniel-Henry
authors.initials: DH
authors.lastname: Caignard
authors.forename: Alain
authors.initials: A
authors.lastname: Pierré
authors.forename: Stéphane
authors.initials: S
authors.lastname: Léonce
authors.forename: Gérard
authors.initials: G
authors.lastname: Coudert
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles