title: Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua.
abstract: A super-carbon-chain compound, symbiopolyol (1a), was isolated from a symbiotic dinoflagellate of the jellyfish Mastigias papua. Although a direct comparison between symbiopolyol (1a) and lingshuiol B has not been completed, symbiopolyol (1a) is suggested to be the enantiomer of lingshuiol B. The structure of 1a, including its partial relative configuration, was elucidated on the basis of interpretation of spectroscopic data and chemical transformations. This compound exhibited significant inhibitory activity against the expression of VCAM-1 in human umbilical vein endothelial cells (HUVEC).
authors.affiliation: Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan.
authors.forename: Novriyandi
authors.initials: N
authors.lastname: Hanif
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohno
authors.forename: Makoto
authors.initials: M
authors.lastname: Kitamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uemura
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D037401:Scyphozoa / Q000382:microbiology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000475:Alkenes; D011714:Pyrans; D019010:Vascular Cell Adhesion Molecule-1; C551655:symbiopolyol