title: [Lipid profile in obese and non-obese women with polycystic ovary syndrome treated with metformin].
abstract: OBJECTIVE
  To compare lipid and lipoprotein concentrations between obese and non-obese women with a diagnosis of polycystic ovary syndrome (PCOS) treated with metformin for 6 months.
  
  
  METHODS
  Sixty-five women with a diagnosis of PCOS were included. The presence of obesity, serum concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were recorded before and after 6 months of metformin treatment. The women were divided in two groups of 34 obese women (group A; body mass index >27 kg/m(2)) and 31 non-obese women (group B; body mass index (<27 kg/m(2)).
  
  
  RESULTS
  Significant differences in body mass index, waist-hip ratio, cholesterol, triglycerides, LDL-c and HDL-c were found in group A compared with group B (p<0.05). In obese women, serum triglyceride and LDL-c concentrations were significantly reduced (p<0.05), while serum concentrations of HDL-c were significantly increased (p<0.05) after 6 months of treatment. In non-obese women, none of these lipid profile modifications were considered significant (p=ns).
  
  
  CONCLUSIONS
  Metformin use for 6 months modified triglyceride, LDL-c and HDL-c concentrations compared with initial values in obese women with PCOS while no significant modifications in lipid or lipoprotein concentrations were observed in non-obese women.
authors.affiliation: Servicio de Medicina Interna, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela. sippenbauch@gmail.com
authors.forename: Daimarys
authors.initials: D
authors.lastname: Quintero-Castillo
authors.forename: Hedy
authors.initials: H
authors.lastname: Luz-Araujo
authors.forename: Mery
authors.initials: M
authors.lastname: Guerra-Velázquez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Reyna-Villasmil
authors.forename: Joel
authors.initials: J
authors.lastname: Santos Bolívar
authors.forename: Duly
authors.initials: D
authors.lastname: Torres-Cepeda
authors.forename: Jorly
authors.initials: J
authors.lastname: Mejia-Montilla
authors.forename: Nadia
authors.initials: N
authors.lastname: Reyna-Villasmil
mesh_terms: D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008687:Metformin / Q000627:therapeutic use*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; D008687:Metformin; D002784:Cholesterol