Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study.
We performed a single-arm, open-label pilot trial of the anti-inflammatory drug pentoxifylline to reduce systemic inflammation and improve endothelial function, measured by flow-mediated dilation of the brachial artery, in HIV-infected patients not requiring antiretroviral therapy. Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferon-gamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway.
Gupta
Samir K
SK
Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA. sgupta1@iupui.edu <sgupta1@iupui.edu>
Johnson
Raymond M
RM
Mather
Kieren J
KJ
Clauss
Matthias
M
Rehman
Jalees
J
Saha
Chandan
C
Desta
Zeruesenay
Z
Dubé
Michael P
MP
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001916:Brachial Artery / Q000187:drug effects / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D010431:Pentoxifylline