[MR spectroscopy in dementia].
With an increasingly aging population we are faced with the problem of an increasing number of dementia patients. In addition to clinical, neuropsychological and laboratory procedures, MRI plays an important role in the early diagnosis of dementia. In addition to various morphological changes functional changes can also help in the diagnosis and differential diagnosis of dementia. Overall the diagnosis of dementia can be improved by using parameters from MR spectroscopy. This article focuses on MR spectroscopic changes in the physiological aging process as well as on changes in mild cognitive impairment a precursor of Alzheimer's dementia, in Alzheimer's dementia, frontotemporal dementia, vascular dementia and Lewy body dementia.
Hauser
T
T
Abteilung E010, Radiologie, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg , Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland. t.hauser@dkfz.de
Gerigk
L
L
Giesel
F
F
Schuster
L
L
Essig
M
M
D001224:Aspartic Acid / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D003404:Creatinine / Q000032:analysis*; D003704:Dementia / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009842:Oligopeptides; D010767:Phosphorylcholine / Q000032:analysis*; D011522:Protons
D015415:Biomarkers; D009842:Oligopeptides; D011522:Protons; D010767:Phosphorylcholine; D001224:Aspartic Acid; C046967:acetylaspartyl-valyl-aspartyl-alanine; D003404:Creatinine