title: [Pre-emptive analgesia in the complex of multicomponent general anesthesia in pediatric neurosurgery].
abstract: The study enrolled 30 patients aged 2 to 18 years, who had been operated on at the Prof A. L. Polenov Russian Neurosurgical Institute in 2008-2009. The patients had undergone total intravenous anesthesia with the opioid analgesic fentanyl (3.5 microg/kg x hr), the central alpha 2-adrenoblocker clofelin (1.2 microg/kg x hr), recofol (3 mg/kg x hr) under myorelaxation (arduan, esmeron) and artificial ventilation. Assessment of a neuroendocrine response and postoperative analgesia levels by the physiological and self-appraisal scales showed the high efficacy of pre-emptive analgesia using paracetamol in the complex of multicomponent anesthesia using the central alpha 2-adrenoblocker clofelin.
authors.forename: I A
authors.initials: IA
authors.lastname: Savvina
authors.forename: A O
authors.initials: AO
authors.lastname: Lebedeva
authors.forename: N V
authors.initials: NV
authors.lastname: Driagina
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage; D000698:Analgesia / Q000379:methods*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000768:Anesthesia, General / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D016343:Monitoring, Intraoperative; D019635:Neurosurgical Procedures; D010147:Pain Measurement; D010149:Postoperative Pain / Q000097:blood / Q000517:prevention & control* / Q000523:psychology; D013315:Stress, Psychological / Q000097:blood / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000316:Adrenergic alpha-Agonists; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D015415:Biomarkers; D000082:Acetaminophen; D003000:Clonidine