Hemolytic disease of newborn due to anti-Jk b in a woman with high risk pregnancy.
This case illustrates the importance of blood group antibodies in antenatal serology other than Rh system as a cause of hemolytic disease of newborn (HDN). In India, antenatal antibody screening is done at majority of transfusion centers in only Rh (D) negative mothers. In this multigravida woman with high risk obstetrical history, an antenatal antibody screening by indirect antiglobulin test (IAT) was not performed as she was Rh (D) positive. Postnatal work up for the pathological jaundice in the neonate revealed that red cell alloimmunization had occurred due to anti-Jk(b). We conclude that antenatal antibody screening should be done in all pregnant women irrespective of the D antigen status to detect and manage red cell alloimmunization to any other clinically significant blood group antigens.
Thakral
Beenu
B
Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. beenuthakral@gmail.com
Malhotra
Sheetal
S
Saluja
Karan
K
Kumar
Praveen
P
Marwaha
Neelam
N
D000328:Adult; D004899:Erythroblastosis, Fetal / Q000097:blood* / Q000276:immunology*; D005260:Female; D006801:Humans; D007194:India; D007231:Infant, Newborn / Q000276:immunology; D007518:Isoantibodies / Q000097:blood; D007667:Kidd Blood-Group System / Q000276:immunology*; D011247:Pregnancy; D018566:Pregnancy, High-Risk / Q000097:blood / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000097:blood
D007518:Isoantibodies; D007667:Kidd Blood-Group System; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen