Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease.
Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.
Chae
Joon-Seok
JS
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea.
Choi
Kyoung-Seong
KS
D000818:Animals; D018173:Circoviridae Infections / Q000276:immunology / Q000378:metabolism / Q000662:veterinary*; D017925:Circovirus / Q000145:classification*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology*; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000276:immunology / Q000378:metabolism / Q000662:veterinary* / Q000821:virology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D012333:RNA, Messenger