[Novel concepts in beta-adrenergic receptor signaling: therapeutic options for heart failure].
Heart failure is a common and complex clinical syndrome characterized by progressive ventricular dilatation, depressed contractile function and premature death. Abnormalities in the beta-adrenergic receptor (betaAR) signaling such as betaAR down-regulation and desensitization are hallmarks of heart failure. Results from previous studies suggest that chronic betaAR dysfunction in the failing heart is maladaptive and contributes to the deterioration in cardiac function. In this review we will discuss a number of recent studies on betaAR signaling and addressing the role of phosphoinositide-3 kinase (PI3K) in the development of betaAR dysfunction and the progression of heart failure. Novel possible strategies to ameliorate cardiac dysfunction in heart failure through the competitive inhibition of PI3K are also described.
Schiattarella
Gabriele Giacomo
GG
Cattedra di Cardiologia, Dipartimento Universitario di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi Federico II, Napoli.
Perrino
Cinzia
C
Gargiulo
Giuseppe
G
Sorrentino
Sabato
S
Franzone
Anna
A
Capretti
Giuliana
G
Esposito
Giovanni
G
Chiariello
Massimo
M
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D015536:Down-Regulation; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D053208:Kaplan-Meier Estimate; D051379:Mice; D008822:Mice, Transgenic; D008967:Molecular Biology; D009200:Myocardial Contraction; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010766:Phosphorylation; D011379:Prognosis; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015398:Signal Transduction
D010716:Phosphatidylinositols; D011943:Receptors, Adrenergic, beta; D019869:Phosphatidylinositol 3-Kinases