Three new antioxidant C-glucosylanthrones from Aloe nobilis.
Three new C-glucosylanthrones, 3'-O-acetyl-5-hydroxylaloin A (2), 2',6'-O-diacetyl-5-hydroxylaloin A (4), and 4',6'-O-diacetyl-5-hydroxylaloin A (5), along with three known compounds, 5-hydroxyaloin A (1), 6'-acetyl-5-hydroxylaloin A (3), and 4-methoxy-6-(2',4'-dihydroxy-6'-methylphenyl)-pyran-2-one (6), were isolated from the leaves of Aloe nobilis, and their structures were elucidated on the basis of spectroscopic evidences. Compounds 1, 2, 4 and 5 showed antioxidant activity with inhibitory rates of 31.0, 34.0, 34.0, and 42.0%, respectively, at 10(-5) M.
Lv
Liang
L
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Beijing, China.
Tian
Xiao-Yan
XY
Fang
Wei-Shuo
WS
D000504:Aloe / Q000737:chemistry*; D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
C550591:2',6'-O-diacetyl-5-hydroxylaloin A; C550590:3'-O-acetyl-5-hydroxylaloin A; C550592:4',6'-O-diacetyl-5-hydroxylaloin A; D000873:Anthracenes; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005960:Glucosides