title: Health-related quality of life and healthcare resource use in European patients with plaque psoriasis: an association independent of observed disease severity.
abstract: BACKGROUND
  Healthcare resource utilization (HCRU) by patients with plaque psoriasis increases with skin lesion severity; however, the relationship between patient quality of life (QoL), which correlates only weakly with clinical severity, and HCRU is less understood.
  
  
  OBJECTIVE
  To evaluate the relationship between QoL, HCRU and employment in European patients with plaque psoriasis.
  
  
  METHODS
  Patients (n = 897) were recruited in five European countries. Data were analysed by group according to the Dermatology Life Quality Index (DLQI): ≤ 10 (better QoL) and > 10 (worse QoL).
  
  
  RESULTS
  Mean numbers of primary dermatologist visits and hospitalizations were significantly higher for patients with DLQI > 10. Likewise, significantly more patients with worse QoL reported employment disadvantages. Significant differences were maintained even after adjusting for age, gender and body surface area affected.
  
  
  CONCLUSIONS
  In patients with plaque psoriasis, poorer QoL is associated with increased HCRU, independent of clinical severity. This suggests that QoL, in addition to skin lesion severity, should be considered in predicting the economic burden of disease.
authors.affiliation: Specialty Care, Pfizer, Collegeville, PA 19426, USA. Reiko.Sato@pfizer.com
authors.forename: R
authors.initials: R
authors.lastname: Sato
authors.forename: G
authors.initials: G
authors.lastname: Milligan
authors.forename: C
authors.initials: C
authors.lastname: Molta
authors.forename: A
authors.initials: A
authors.lastname: Singh
mesh_terms: D000328:Adult; D005060:Europe; D005260:Female; D006301:Health Services Needs and Demand / Q000191:economics / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000503:physiopathology* / Q000523:psychology; D011788:Quality of Life; D012044:Regression Analysis; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D044465:White People; D055815:Young Adult