title: Predicting pregnancy in HIV-1-discordant couples.
abstract: This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, WA 98104-2499, USA. brguth@u.washington.edu
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Guthrie
authors.forename: Robert Y
authors.initials: RY
authors.lastname: Choi
authors.forename: Rose
authors.initials: R
authors.lastname: Bosire
authors.forename: James N
authors.initials: JN
authors.lastname: Kiarie
authors.forename: Romel D
authors.initials: RD
authors.lastname: Mackelprang
authors.forename: Anne
authors.initials: A
authors.lastname: Gatuguta
authors.forename: Grace C
authors.initials: GC
authors.lastname: John-Stewart
authors.forename: Carey
authors.initials: C
authors.lastname: Farquhar
mesh_terms: D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D015658:HIV Infections / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D015994:Incidence; D007630:Kenya / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012098:Reproduction; D012307:Risk Factors; D018454:Spouses / Q000706:statistics & numerical data; D055815:Young Adult