Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells.
It has been demonstrated that the Hericium erinaceus (HE) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which HE inhibits human hepatocellular carcinoma growth remain unknown. Our study demonstrates that HE acts as an enhancer to sensitize doxorubicin (Dox)-mediated apoptotic signaling, and this sensitization can be achieved by reducing c-FLIP expression via JNK activation and enhancing intracellular Dox accumulation via the inhibition of NF-κB activity. These findings suggest that HE in combination with Dox serves as an effective tool for treating drug-resistant human hepatocellular carcinoma.
Lee
Jong Seok
JS
Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Republic of Korea.
Hong
Eock Kee
EK
D000363:Agaricales / Q000737:chemistry*; D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*
D011134:Polysaccharides; D004317:Doxorubicin