title: Role of small bowel follow-through in diagnosing inflammation of the terminal ileum in pediatric patients.
abstract: BACKGROUND
  The small bowel follow-through (SBFT) is a noninvasive imaging modality for evaluating terminal ileum (TI) inflammation. The accuracy of this modality in pediatric patients is not well established.
  
  
  METHODS
  We retrospectively determined the sensitivity and specificity of SBFT for detecting TI inflammation diagnosed on histology in 93 pediatric patients studied in a single institution.
  
  
  RESULTS
  The mean age at the first study was 12.9 years (range 1.1-20.9 years). Forty-five percent were girls. Twenty-five patients (27%) had abnormal TIs on SBFT. Seventeen patients (18%) had TI inflammation diagnosed by biopsy. The sensitivity of SBFT was 59% and the specificity was 80% for detecting TI inflammation diagnosed on histology. Sensitivity and specificity did not change by demographic factors, final diagnoses, presenting symptoms, or laboratory parameters, reflecting the presence of intestinal inflammation.
  
  
  CONCLUSIONS
  The sensitivity and specificity of SBFT in pediatric patients were poor and did not vary with demographic factors, final diagnoses, presenting symptoms, or laboratory parameters. Prospective longitudinal studies comparing various imaging modalities (SBFT, magnetic resonance enterography, and capsule endoscopy) are required to determine which is the most effective tool for evaluating pediatric patients for TI inflammation.
authors.affiliation: UCSF Children's Hospital, San Francisco, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Stenerson
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.forename: Melvin B
authors.initials: MB
authors.lastname: Heyman
authors.forename: Grace E
authors.initials: GE
authors.lastname: Kim
authors.forename: Neera
authors.initials: N
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007082:Ileum / Q000000981:diagnostic imaging; D007223:Infant; D007249:Inflammation / Q000000981:diagnostic imaging*; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D008297:Male; D011859:Radiography; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult