Immunotherapy in food allergy.
Food allergies are caused by immune responses to food proteins and represent a breakdown of oral tolerance. They can range from mild pruritus to life-threatening anaphylaxis. The only current consensus for treatment is food avoidance, which is fraught with compliance issues. For this reason, there has been recent interest in immunotherapy, which may induce desensitization and possibly even tolerance. Through these effects, immunotherapy may decrease the potential for adverse serious reactions with accidental ingestions while potentially leading to an overall health benefit. In this review, we discuss the mechanisms of food allergy and give an overview of the various immunotherapeutic options and current supporting evidence, as well as look towards the future of potential novel therapeutic modalities.
Kamdar
Toral
T
Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, 240 E Huron, M315 Chicago, IL 60610, USA.
Bryce
Paul J
PJ
D000485:Allergens / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods* / Q000639:trends; D005512:Food Hypersensitivity / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007167:Immunotherapy / Q000379:methods* / Q000639:trends
D000485:Allergens