Micro- and nanocarrier-mediated lung targeting.
BACKGROUND
Drug delivery to lungs appears to be an attractive proposition on account of the large surface area of the alveolar region; it provides tremendous opportunities to improve drug therapies both systemically and locally using new drug delivery systems. Administration of drugs directly to the lungs is the most appropriate route in the treatment of asthma and other pulmonary diseases such as tuberculosis, chronic obstructive pulmonary disease and lung cancer.


METHODS
This review focuses on the utilization of nano- and microcarriers such as microspheres, nanoparticles, liposomes, niosomes and dendrimers for targeted delivery of bioactive molecules to lungs.


RESULTS
This review sheds light on the current status of nano- and microcarrier-mediated lung targeting of bioactive compounds.


CONCLUSIONS
The literature review shows that carriers could supplement sustained drug delivery to the lungs, extended duration of action, reduced therapeutic dose, improved patient compliance, and reduced adverse effects of highly toxic drugs. There is still a need to identify more specific receptors that are present exclusively in the lungs. The identification of such receptors may also facilitate drug targeting to further specific parts of the lungs, such as bronchioles and alveoli.
Kurmi
Balak D
BD
Dr Hari Singh Gour University, Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Sagar 470 003, India.
Kayat
Jitendra
J
Gajbhiye
Virendra
V
Tekade
Rakesh K
RK
Jain
Narendra K
NK
D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008863:Microspheres; D053758:Nanoparticles; D036103:Nanotechnology
D004337:Drug Carriers