title: Acute dysphonia secondary to vocal fold hemorrhage after vardenafil use.
abstract: Owing to their vasodilatory effects, the phosphodiesterase-5 inhibitors have become widely used for the treatment of erectile dysfunction. Among the reported adverse events of these agents are epistaxis, variceal bleeding, intracranial hemorrhage, and hemorrhoidal bleeding. We report a case of vocal fold hemorrhage that occurred after vardenafil use in a 31-year-old man who was a professional singer.
authors.affiliation: Department of Otolaryngology, Vanderbilt University School of Medicine, 7302 Medical Center East, South Tower, 1215 21st Ave. South, Nashville, TN 37232-8783, USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Singh
authors.forename: Seth M
authors.initials: SM
authors.lastname: Cohen
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
authors.forename: J Pieter
authors.initials: JP
authors.lastname: Noordzij
authors.forename: C Gaelyn
authors.initials: CG
authors.lastname: Garrett
authors.forename: Robert H
authors.initials: RH
authors.lastname: Ossoff
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D055154:Dysphonia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects; D014227:Triazines / Q000009:adverse effects; D000069058:Vardenafil Dihydrochloride; D014665:Vasodilator Agents / Q000009:adverse effects*; D014827:Vocal Cords / Q000187:drug effects / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D014665:Vasodilator Agents; D000069058:Vardenafil Dihydrochloride