title: The management of systemic lupus erythematosus: Facts and controversies.
abstract: Systemic lupus erythematosus is a multisystem disease of unknown etiology in which dysregulation of the innate and adaptive immune systems has a major effect in the pathogenesis of the disease. The treatment should be tailored for each patient according to how the disease manifests itself. Although there is no cure for systemic lupus erythematosus, the current treatment, using anti-inflammatory, antimalarial, and immunosuppressive agents, is fairly effective, but serious adverse events are possible. New biologic agents that target various components of the immune system recently have been developed for the treatment of patients with systemic lupus erythematosus.
authors.affiliation: Department of Medicine B, Clinical Immunology Allergy and AIDS Center, Kaplan Medical Center, Rehovot 76100, Israel.
authors.forename: Daniel
authors.initials: D
authors.lastname: Elbirt
authors.forename: Dalia
authors.initials: D
authors.lastname: Sthoeger
authors.forename: Ilan
authors.initials: I
authors.lastname: Asher
authors.forename: Zev Moshe
authors.initials: ZM
authors.lastname: Sthoeger
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000473:pathology; D010347:Patient Care Planning; D017410:Practice Guidelines as Topic
chemical_list: D000893:Anti-Inflammatory Agents; D000962:Antimalarials; D007166:Immunosuppressive Agents