title: [Prophylactic and therapeutic vaccines against human papilloma virus].
abstract: Infection with human papilloma virus (HPV) has been identified as the cause of recurrent papillomatosis and of a subgroup of squamous cell carcinomas of the head and neck. A change in prevalence of these lesions, especially for oropharyngeal carcinoma, can be expected as a consequence of the introduction of prophylactic HPV vaccines for young women, targeting the most frequent high- and low-risk HPV subtypes. Vaccination for the major low-risk HPV types has proven to be highly effective against genital warts and activity against papillomatosis can be expected. The possibilities of prophylactic HPV vaccination as well as new developments and the rationale for therapeutic vaccines are discussed on the basis of the current literature.
authors.affiliation: Hals-Nasen-Ohren-Klinik, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Deutschland. andreas.albers@charite.de
authors.forename: A E
authors.initials: AE
authors.lastname: Albers
authors.forename: T K
authors.initials: TK
authors.lastname: Hoffmann
authors.forename: J P
authors.initials: JP
authors.lastname: Klussmann
authors.forename: A M
authors.initials: AM
authors.lastname: Kaufmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control*; D002648:Child; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D005260:Female; D052140:Human papillomavirus 11 / Q000276:immunology; D052162:Human papillomavirus 16 / Q000276:immunology; D052161:Human papillomavirus 18 / Q000276:immunology; D052163:Human papillomavirus 6 / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D010039:Otorhinolaryngologic Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control*; D010212:Papilloma / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000627:therapeutic use*; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines