[Determination and confirmation of cyanuric acid in infant formula using mixed-mode solid-phase extraction cartridge clean up-gas chromatography-mass spectrometry].
A method is presented for the quantitative determination and confirmation of cyanuric acid in infant formula by mixed-mode solid-phase extraction cartridge clean up-gas chromatography-mass spectrometry (GC-MS). Cyanuric acid was extracted from infant formula with an acetic acid solution at 84 degrees C. An aliquot of the supernatant was cleaned up using mixed-mode solid-phase extraction cartridge containing C18 and graphitized carbon black (GCB), and evaporated to dryness under nitrogen. The residues were converted to trimethylsilyl derivatives, then determined by GC-MS in selected ion monitoring (SIM) mode. The linear range was from 0.01 -2 mg/L. The recoveries were 80% - 103% and the relative standard deviations were 7.7% - 14.5% in the spiked range of 0.25 -2.5 mg/kg. The limit of detection was 0.10 mg/kg and the limit of quantification was 0.25 mg/kg. The method is rapid, sensitive, accurate, specific, and rugged. It is suitable for the quantitative determination and confirmation of cyanuric acid in infant formula.
Li
Fengge
F
Technical Center of Xinjiang Entry-Exit Inspection and Quarantine Bureau, Urumqi 830063, China. ciqlfg@163.com
Yao
Weiqin
W
Tian
Yanhe
Y
Dou
Hui
H
Su
Min
M
Zhu
Huiping
H
Li
Xin
X
Shen
Mengyuan
M