Determination of human absorbed dose of 201Tl(III)-DTPA-HIgG based on biodistribution data in rats.
To estimate the absorbed dose in normal organs and inflamed tissue following i.v. administration of [201Tl](III)-DTPA-HIgG by using biodistribution data in inﬂamation bearing rats was attempted. The percentages of injected dose per gram of each organ were calculated. The medical internal radiation dose formulation was applied to calculate the absorbed dose for various organs. The inflamed tissue to blood activity concentration ratios were about 19 and 23.3 at 24 and 28 h post-injection, respectively. A 185-MBq injection of 201Tl-DTPA-HIgG into the human body, might result in an estimated absorbed dose of 14.4 mGy for the total body and the highest absorbed dose was in the kidney with 1195 (mGy) and second to the Spleen were the liver, the lungs and the adrenals, which received 250.5 (mGy), 58.64 (mGy) and 56.44 (mGy), respectively. Biodistribution of [201Tl](III)-DTPA-HIgG demonstrated significant inflamed tissue uptake and low muscle and blood uptake, allowing for imaging of inflamed tissues.
Khorrami Moghaddam
Alireza
A
Department of Biomedical Physics and Engineering, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. ar.khorrami@gmail.com
Reza Jalilian
Amir
A
Hayati
Vali
V
Shanehsazzadeh
Saeed
S
D000311:Adrenal Glands / Q000528:radiation effects; D000818:Animals; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry*; D007249:Inflammation; D007554:Isotopes / Q000032:analysis*; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D009132:Muscles / Q000378:metabolism; D004369:Pentetic Acid / Q000737:chemistry*; D011874:Radiometry / Q000379:methods*; D051381:Rats; D013154:Spleen / Q000528:radiation effects; D013793:Thallium / Q000032:analysis*; D013997:Time Factors
D007074:Immunoglobulin G; D007554:Isotopes; D004369:Pentetic Acid; D013793:Thallium