Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans.
Tryptophan, serotonin, and melatonin, present in Jerte Valley cherries, participate in sleep regulation and exhibit antioxidant properties. The effect of the intake of seven different Jerte Valley cherry cultivars on the sleep-wake cycle, 6-sulfatoxymelatonin levels, and urinary total antioxidant capacity in middle-aged and elderly participants was evaluated. Volunteers were subjected to actigraphic monitoring to record and display the temporal patterns of their nocturnal activity and rest. 6-sulfatoxymelatonin and total antioxidant capacity were quantified by enzyme-linked immunosorbent assay and colorimetric assay kits, respectively. The intake of each of the cherry cultivars produced beneficial effects on actual sleep time, total nocturnal activity, assumed sleep, and immobility. Also, there were significant increases in 6-sulfatoxymelatonin levels and total antioxidant capacity in urine after the intake of each cultivar. These findings suggested that the intake of Jerte Valley cherries exerted positive effect on sleep and may be seen as a potential nutraceutical tool to counteract oxidation.
Garrido
María
M
Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, Avda. Elvas s/n, 06006 Badajoz, Extremadura, Spain.
Paredes
Sergio D
SD
Cubero
Javier
J
Lozano
Mercedes
M
Toribio-Delgado
Antonio F
AF
Muñoz
Juan L
JL
Reiter
Russel J
RJ
Barriga
Carmen
C
Rodríguez
Ana B
AB
D056044:Actigraphy; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis*; D003124:Colorimetry; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000032:analysis / Q000652:urine; D008875:Middle Aged; D011446:Prospective Studies; D027861:Prunus / Q000737:chemistry; D012701:Serotonin / Q000032:analysis; D012890:Sleep; D013030:Spain; D014364:Tryptophan / Q000032:analysis
D000975:Antioxidants; C054513:6-sulfatoxymelatonin; D012701:Serotonin; D014364:Tryptophan; D008550:Melatonin