[Epstein-Barr virus associated pulmonary lymphoma in Sjögren's syndrome].
A 71 year-old man with primary Sjögren's syndrome developed pulmonary opacities within two years of the diagnosis. Videothoracoscopic lung biopsy demonstrated high grade, B-cell, CD20+, large-cell lymphoma, associated with Epstein-Barr virus (RNA EBERs of the virus were expressed by the lymphoma cells). The condition initially improved with rituximab-CHOP treatment, but recurrence of the lymphoma was fatal.


CONCLUSIONS
High-grade B-cell lymphoma associated with EBV can occur in Sjögren's syndrome in the absence of long-term immunosuppressive therapy.
Traclet
J
J
UMR 754, service de pneumologie, centre de référence des maladies pulmonaires rares, hôpital Louis-Pradel, université de Lyon, 69677 Lyon (Bron) cedex, France.
Cottin
V
V
Duvert
B
B
Thivolet-Bejui
F
F
Berger
F
F
Coiffier
B
B
Cordier
J-F
JF
D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000821:virology*; D008297:Male; D012859:Sjogren's Syndrome / Q000150:complications*