Proinflammatory cytokines, hepatocyte growth factor and adipokines in peritoneal dialysis patients.
Chronic inflammation is a well-recognized complication in dialysis patients and a potential role of the adipose tissue as an important tissue of origin contributing to inflammation has been proposed. Stable peritoneal dialysis (PD) patients were enrolled to investigate the relationship between serum levels of proinflammatory cytokines and adipokines. Our results revealed that there was a strong association between high sensitivity C-reactive protein and interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) but not with IL-10 and IL-18. IL-6 correlated with TNF-alpha, IL-10, and IL-18. No association was found between IL-10 and IL-18. Adiponectin was positively correlated with all proinflammatory cytokines, except IL-10. No significant association was found between resistin and proinflammatory cytokines. Hepatocyte growth factor (HGF) was directly related to proinflammatory cytokines but not with adipokines. The presence of residual kidney function (RKF) affected IL-6, TNF-alpha, and HGF levels. The peritoneal transport property did not influence inflammatory cytokine and adipokine levels. In conclusion, there was a close relationship between proinflammatory cytokines and adipokines. HGF correlated with proinflammatory cytokines but not with adipokines. The PD-related factors such as RKF, peritoneal property and dialysis glucose load affected levels of proinflammatory cytokines. Body mass index was an important determinant of leptin and adiponectin in PD patients.
Lee
Chien-Te
CT
Department of Internal Medicine, Division of Nephrology, Chang-Gung Memorial Hospital Kaohsiung Medical Center, Chang-Gung University College of Medicine, Kaohsiung, Taiwan.
Ng
Hwee-Yeong
HY
Hsu
Chung-Yao
CY
Tsai
Yu-Che
YC
Yang
Yu-Kun
YK
Chen
Te-Chuan
TC
Chiou
Terry Ting-Yu
TT
Kuo
Chien-Chun
CC
Lee
Wen-Chin
WC
Hsu
Kao-Tai
KT
D054392:Adipokines / Q000097:blood*; D000328:Adult; D001692:Biological Transport; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood*; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000378:metabolism
D054392:Adipokines; D016207:Cytokines; D017228:Hepatocyte Growth Factor