title: Protection of mouse heart against hypoxic damage by AMP deaminase inhibition.
abstract: Clinical observation in patients with heart disease indicates that reduced activity of AMP deaminase could be protective in heart failure and ischemic heart disease. This study evaluated the effect of 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo [4,5-d][1,3]diazepin-8-ol, an AMP deaminase inhibitor (AMPDI) in the mouse heart subjected to hypoxia. ApoE/LDLR knock-out mice were subjected to reduced oxygen tension in breathing air. AMPDI was infused before hypoxia in the treated group. We observed amelioration of elcetrocardiographic changes during hypoxia in the treated group that are consistent with a protective effect.
authors.affiliation: Department of Biochemistry, Medical University of Gdansk, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Borkowski
authors.forename: E M
authors.initials: EM
authors.lastname: Slominska
authors.forename: C
authors.initials: C
authors.lastname: Orlewska
authors.forename: S
authors.initials: S
authors.lastname: Chlopicki
authors.forename: P
authors.initials: P
authors.lastname: Siondalski
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
authors.forename: R T
authors.initials: RT
authors.lastname: Smolenski
mesh_terms: D000659:AMP Deaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D018345:Mice, Knockout
chemical_list: D004791:Enzyme Inhibitors; D000659:AMP Deaminase