title: Disseminated intravascular large-cell lymphoma with initial presentation mimicking Guillain-Barré syndrome.
abstract: We report a patient with intravascular large B-cell lymphoma who initially presented with acute ascending weakness and sensory changes. Electrodiagnostic testing and cerebral spinal fluid (CSF) studies were initially suggestive of a demyelinating polyneuropathy. Further clinical evaluation and testing were consistent with mononeuropathy multiplex. Autopsy revealed disseminated intravascular large-cell lymphoma. Intravascular large-cell lymphoma should be considered in the differential diagnosis of a rapidly evolving neuropathy associated with other organ involvement.
authors.affiliation: Department of Neurology, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA.
authors.forename: Qin Li
authors.initials: QL
authors.lastname: Jiang
authors.forename: Peter
authors.initials: P
authors.lastname: Pytel
authors.forename: Julie
authors.initials: J
authors.lastname: Rowin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001344:Autopsy; D001369:Axons / Q000473:pathology; D003937:Diagnosis, Differential; D004568:Electrodiagnosis; D017809:Fatal Outcome; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000134:cerebrospinal fluid / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018908:Muscle Weakness / Q000209:etiology; D018482:Muscle, Skeletal / Q000473:pathology; D009431:Neural Conduction / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology; D011680:Pupil / Q000502:physiology; D012131:Respiratory Insufficiency / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids