title: Two decades at the cross-roads of biology, physics and epidemiology: lessons learned in [18F-]FDG positron emission tomography in oncology.
abstract: [18F-]FDG PET(-CT) is a primarily quantitative imaging technology that is rapidly gaining ground in clinical oncology; initially for staging and diagnosis, and now increasingly as a biomarker of response to therapy. In spite of 20 years of clinical research, there is discussion about its implementation among clinicians, decision-makers and other parties about its implementation. To some extent, this relates to heterogeneity of the PET results and of trial designs, but also to differences in levels of evidence required by various parties. With PET, biological and quantitative imaging is entering the clinical domain. The current subjective perspective reviews these aspects to help clinicians understand biological and physical elements underlying [18F-]FDG PET to increase the clinical awareness of its potential and limitations.
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
authors.forename: Saiyada N F
authors.initials: SN
authors.lastname: Rizvi
authors.forename: Emile F
authors.initials: EF
authors.lastname: Comans
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.forename: Harm
authors.initials: H
authors.lastname: van Tinteren
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000639:trends*; D017410:Practice Guidelines as Topic; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18