New bufadienolides and C(23) steroids from the venom of Bufo bufo gargarizans.
Six new bufadienolides (1-6) and two new C(23) steroids (7 and 8), together with three known compounds (9-11) were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated by spectroscopic analysis and single-crystal X-ray diffraction. In vitro cytotoxicities of all compounds were evaluated in A549 cancer cell line. Compounds 2, 3 and 10 showed significant cytotoxic activities.
Tian
Hai-Yan
HY
Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Wang
Lei
L
Zhang
Xiao-Qi
XQ
Zhang
Dong-Mei
DM
Wang
Ying
Y
Liu
Jun-Shan
JS
Jiang
Ren-Wang
RW
Ye
Wen-Cai
WC
D000664:Amphibian Venoms / Q000737:chemistry*; D000818:Animals; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002023:Bufo bufo; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50
D000664:Amphibian Venoms; D002018:Bufanolides; C087925:bufadienolide