Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature.
This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung.On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation.
Klingen
Tor A
TA
Department of Pathology, Vestfold County Hospital, Halfdan Wilhelmsens Alle' 17, N-3116 Tønsberg, Norway. tor.klingen@siv.no
Chen
Ying
Y
Gundersen
Marian D
MD
Aas
Hans
H
Westre
Bjørn
B
Sauer
Torill
T
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008408:Mastectomy; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000032:analysis*; D049268:Positron-Emission Tomography; D000074482:Thyroid Nuclear Factor 1; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000032:analysis*
D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors