Copper-catalyzed intramolecular C-H oxidation/acylation of formyl-N-arylformamides leading to indoline-2,3-diones.
A new, efficient Cu-catalyzed intramolecular C-H oxidation/acylation method has been developed for the synthesis of substituted indoline-2,3-diones (isatins). In the presence of CuCl(2) and O(2), a variety of formyl-N-arylformamides underwent the tandem reaction to afford the corresponding indoline-2,3-diones in moderate to good yields. It is noteworthy that the reaction serves as the first example of transition-metal-catalyzed transformation for the preparation of indoline-2,3-diones.
Tang
Bo-Xiao
BX
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China.
Song
Ren-Jie
RJ
Wu
Cui-Yan
CY
Liu
Yu
Y
Zhou
Ming-Bo
MB
Wei
Wen-Ting
WT
Deng
Guo-Bo
GB
Yin
Du-Lin
DL
Li
Jin-Heng
JH
D000215:Acylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005559:Formamides / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction
D005559:Formamides; D007211:Indoles; D002244:Carbon; D003300:Copper; D006859:Hydrogen