title: Antimicrobial photodynamic inactivation and photodynamic therapy for infections.
abstract: Photodynamic therapy (PDT) was initially discovered over 100 years ago by its ability to kill microorganisms, but its use to treat infections clinically has not been much developed. However, the present relentless increase in antibiotic resistance worldwide and the emergence of strains that are resistant to all known antibiotics has stimulated research into novel antimicrobial strategies such as PDT that are thought to be unlikely to lead to the development of resistance. In this chapter we will cover the use of PDT to kill pathogenic microbial cells in vitro and describe a mouse model of localized infection and its treatment by PDT without causing excessive damage to the host tissue.
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Liyi
authors.initials: L
authors.lastname: Huang
authors.forename: Tianhong
authors.initials: T
authors.lastname: Dai
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hamblin
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010778:Photochemotherapy / Q000379:methods*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000528:radiation effects; D013211:Staphylococcus aureus / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000890:Anti-Infective Agents