title: PI3Ks in lymphocyte signaling and development.
abstract: Lymphocyte development and function are regulated by tyrosine kinase and G-protein coupled receptors. Each of these classes of receptors activates phosphoinositide 3-kinase (PI3K). In this chapter, we summarize current understanding of how PI3K contributes to key aspects of the adaptive immune system.
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. klaus.okkenhaug@bbsrc.ac.uk
authors.forename: Klaus
authors.initials: K
authors.lastname: Okkenhaug
authors.forename: David A
authors.initials: DA
authors.lastname: Fruman
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D006801:Humans; D017578:Immunoglobulin Class Switching; D008214:Lymphocytes / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D019869:Phosphatidylinositol 3-Kinases