Adipose tissue-derived stem cells: the friendly side of a classic cardiovascular foe.
Recently, the existence of a population of stem cells located in the adipose tissue has been observed. Adipose-derived stem cells are able to differentiate into multiple cell lineages including cardiac myocytes. Hence, adipose-derived cells are emerging as a new source of adult stem cells for cardiovascular repair. In this review, we discuss the basic principles of adipose-derived stem cells (types and characteristics, obtention processes, immunophenotypic characterization, and cell potency), the initial experimental studies, and the currently ongoing clinical trials.
Sanz-Ruiz
Ricardo
R
Cardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Santos
María Eugenia Fernández
ME
Muñoa
Marta Domínguez
MD
Martín
Ingrid Ludwig
IL
Parma
Radoslaw
R
Fernández
Pedro L Sánchez
PL
Fernández-Avilés
Francisco
F
D000273:Adipose Tissue / Q000166:cytology* / Q000276:immunology; D053687:Adult Stem Cells / Q000276:immunology / Q000637:transplantation*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002986:Clinical Trials as Topic; D006331:Heart Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D039902:Multipotent Stem Cells / Q000276:immunology / Q000637:transplantation*; D032383:Myocytes, Cardiac / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D010641:Phenotype; D012038:Regeneration; D033581:Stem Cell Transplantation; D016896:Treatment Outcome