Optimal duration of preoperative anti-helminthic therapy for pulmonary hydatid surgery.
BACKGROUND
The optimal duration of preoperative anti-helminths for prevention of recurrences in pulmonary hydatidosis is unclear, although 1-3 weeks of therapy is routinely used.


METHODS
Forty-five patients of pulmonary hydatid disease were randomly assigned into four groups to receive either 0, 2, 4 or 8 weeks of preoperative albendazole (ABZ) and praziquantel (PZQ). Viability of the scolices in the fluid harvested at surgery (methylene blue staining) and ability to produce peritoneal hydatids in mice (intra-peritoneal inoculation) were compared in different groups.


RESULTS
The percentage viability of the scolices as a whole was significantly (P < 0.001) lower in the treated cysts (n= 36, mean 43.5 +/- 35.69) compared with the untreated cysts (n= 8, mean 94.75 +/- 7.21). The viability progressively decreased with increasing durations of chemotherapy (P < 0.001). Mean percentage viability of scolices was 88.72 +/- 4.91% in patients treated for 2 weeks (n= 12), 38.09 +/- 9.10% after 4 weeks (n= 11) and 8.1 +/- 9.23% after 8 weeks (n= 14). Intra-peritoneal mice inoculation was positive in 90% of the cysts that received therapy for 2 weeks or less and none of the patients who received therapy for 8 weeks had a positive inoculation.


CONCLUSIONS
Preoperative combination therapy with ABZ and PZQ effects a scolicidal response which increases with the increasing duration of the preoperative chemotherapy, and a 4-week course of the combination chemotherapeutic agents seems to be the minimum required duration for ensuring scolicidal activity enough to prevent spillage-induced recurrences following pulmonary hydatidosis.
Koul
Parvaiz A
PA
Department of Internal and Pulmonary Medicine, SheriKashmir Institute of Medical Sciences, Srinagar, Kashmir, India. parvaizk@gmail.com
Singh
Anurag Ambroze
AA
Ahanger
Abdul G
AG
Wahid
Abdul
A
Sofi
Bashir A
BA
D015766:Albendazole / Q000008:administration & dosage*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004445:Echinococcosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D051379:Mice; D011223:Praziquantel / Q000008:administration & dosage*; D011292:Premedication
D000871:Anthelmintics; D011223:Praziquantel; D015766:Albendazole