Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus.
In cattle the interaction between the two genetically and antigenically related bovine lentiviruses, the acutely pathogenic Jembrana disease virus (JDV) and the non-pathogenic Bovine immunodeficiency virus (BIV) has not been reported although both JDV and a BIV-like virus have been reported in the Bali cattle (Bos javanicus) population in Indonesia. The outcome of infection of Bali cattle with the R29 strain of BIV prior to superinfection 42 days later with JDV(TAB/87) was determined. All BIV-inoculated cattle were successfully infected and developed an antibody response to the TM and CA proteins. BIV infection did not prevent subsequent infection with JDV or ameliorate the clinical signs of Jembrana disease in the infected cattle. It did, however, modify the dynamics of the JDV infection with an earlier onset and end of the acute disease process, and a reduction in the duration of viremia that exceeded 10(6) genome copies/ml of plasma.
McNab
Tegan
T
School of Veterinary and Biomedical Science, Murdoch University, Murdoch WA 6150, Australia. tegan.mcnab@gmail.com
Desport
Moira
M
Dobson
Robert
R
Tenaya
I W Masa
IW
Hartaningsih
Nining
N
Wilcox
Graham E
GE
D000818:Animals; D001831:Body Temperature; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000821:virology*; D004797:Enzyme-Linked Immunosorbent Assay; D016087:Immunodeficiency Virus, Bovine / Q000276:immunology; D016180:Lentivirus Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D017960:Lentiviruses, Bovine / Q000276:immunology*; D013997:Time Factors; D019562:Viral Load; D014766:Viremia