title: Alpinia pricei Hayata rhizome extracts have suppressive and preventive potencies against hypercholesterolemia.
abstract: The aim of this study was to investigate the effects of 70% ethanol extracts of Alpinia pricei (APE) on lipid profiles and lipid peroxidation. Syrian hamsters were fed a chow-based hypercholesterolemic diet (HCD) for 2 weeks to induce hypercholesterolemia (>250 mg/dl). To evaluate the potency of APE in suppressing hypercholesterolemia, hamsters were then fed HCD plus a high dose (500 mg/kg body weight) or a low dose (250 mg/kg body weight) of APE, or only HCD for another 4 weeks. We found that hypercholesterolemic hamsters fed a high dose of APE had lower serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels, lower thiobarbituric acid reactive substances (TBARS) and alanine aminotransferase (ALT) activities, lower atherogenic indices (LDL-C/HDL-C and TC/HDL-C ratios), and lower hepatic protein expression of peroxisome proliferators activated receptor gamma (PPARgamma) than hamsters fed a HCD diet. In addition, we also determined the preventive effects of APE on hamsters fed a HCD for 6 weeks. The hypocholesterolemic effects were also found in hamsters co-fed a high dose of APE and HCD for 6weeks. These results suggest that APE has both suppressive and preventive potencies against hypercholesterolemia and has the potency to protect against lipid peroxidation.
authors.affiliation: Departments of Biochemistry, College of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taichung, Taiwan, ROC. nwchang@mail.cmu.edu.tw
authors.forename: N W
authors.initials: NW
authors.lastname: Chang
authors.forename: C T
authors.initials: CT
authors.lastname: Wu
authors.forename: S Y
authors.initials: SY
authors.lastname: Wang
authors.forename: R J
authors.initials: RJ
authors.lastname: Pei
authors.forename: C F
authors.initials: CF
authors.lastname: Lin
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology*; D015153:Blotting, Western; D008078:Cholesterol, LDL / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D008647:Mesocricetus; D047495:PPAR gamma / Q000096:biosynthesis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D047495:PPAR gamma; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D000410:Alanine Transaminase