Nickel-catalyzed C-H alkenylation and alkylation of 1,3,4-oxadiazoles with alkynes and styrenes.
The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.
Mukai
Tomoya
T
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Hirano
Koji
K
Satoh
Tetsuya
T
Miura
Masahiro
M
D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010069:Oxadiazoles / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry; D020058:Styrene / Q000737:chemistry*
D000480:Alkynes; D010069:Oxadiazoles; D020058:Styrene; D002244:Carbon; D009532:Nickel; D006859:Hydrogen; D012643:Selenium