Childhood methylphenidate treatment of ADHD and response to affective stimuli.
Neural correlates of emotional dysregulation in attention-deficit/hyperactivity disorder (ADHD) and persisting influence of Methylphenidate (MPH) still remain insufficiently understood. Decreased activation in the subgenual cingulate and the ventral striatum were found during the perception of positive and negative affective pictures in drug-naïve males with ADHD during childhood (n=10). Males with ADHD during childhood treated with MPH (n=10) did not show any significant differences compared to healthy controls (n=10). Further prospective studies need to clarify direct and indirect mechanisms of MPH treatment that may contribute to emotional processing, which is dysfunctional in males without pharmacological treatment in childhood.
Schlochtermeier
Lorna
L
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Stoy
Meline
M
Schlagenhauf
Florian
F
Wrase
Jana
J
Park
Soyoung Q
SQ
Friedel
Eva
E
Huss
Michael
M
Lehmkuhl
Ulrike
U
Heinz
Andreas
A
Ströhle
Andreas
A
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology*; D001479:Basal Ganglia / Q000503:physiopathology; D002648:Child; D004644:Emotions / Q000187:drug effects* / Q000502:physiology; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
D008774:Methylphenidate