title: Prognosis in patients presenting with non-traumatic coma.
abstract: BACKGROUND
  Studies of patients presenting with coma are limited, and little is known about the prognosis of these cases.
  
  
  OBJECTIVE
  The aim of this study was to investigate the acute and long-term prognosis after an episode of non-traumatic coma.
  
  
  METHODS
  Adults admitted consecutively to an emergency department in Stockholm, Sweden between February 2003 and May 2005 with a Glasgow Coma Scale (GCS) score of 10 or below were enrolled prospectively. All available data were used to explore the cause of the impaired consciousness on admission. Patients surviving hospitalization were followed-up for 2 years regarding survival.
  
  
  RESULTS
  The final study population of 865 patients had the following eight different coma etiologies: poisoning (n = 329), stroke (n = 213), epilepsy (n = 113), circulatory failure (n = 60), infection (n = 56), metabolic disorder (n = 44), respiratory insufficiency (n = 33), and intracranial malignancy (n = 17). The hospital mortality rate among the 865 patients was 26.5%, varying from 0.9% for epilepsy to 71.7% for circulatory failure. The accumulated total 2-year mortality rate was 43.0%, varying from 13.7% for poisoning to 88.2% for malignancy. The level of consciousness on admission also influenced the prognosis: a GCS score of 3-6 was associated with a significantly higher hospital mortality rate than a GCS score of 7-10.
  
  
  CONCLUSIONS
  The prognosis in patients presenting with non-traumatic coma is serious and depends largely on both the level of consciousness on admission and the etiology of the coma. Adding the suspected coma etiology to the routine coma grading of these emergencies may more accurately predict their prognosis.
authors.affiliation: Medical Intensive Care Unit, South Hospital, Stockholm, Sweden.
authors.forename: Sune
authors.initials: S
authors.lastname: Forsberg
authors.forename: Jonas
authors.initials: J
authors.lastname: Höjer
authors.forename: Ulf
authors.initials: U
authors.lastname: Ludwigs
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003128:Coma / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D003243:Consciousness / Q000502:physiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017678:Sex Distribution; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult