title: Pilot study on schizophrenia in Sardinia.
abstract: OBJECTIVE
  Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease.
  
  
  METHODS
  Standard association tests were employed, followed by newer multilocus association methods (genotype patterns).
  
  
  RESULTS
  Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively.
  
  
  CONCLUSIONS
  These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Jurg
authors.initials: J
authors.lastname: Ott
authors.forename: Fabio
authors.initials: F
authors.lastname: Macciardi
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shen
authors.forename: Mauro G
authors.initials: MG
authors.lastname: Carta
authors.forename: Andrea
authors.initials: A
authors.lastname: Murru
authors.forename: Riccardo
authors.initials: R
authors.lastname: Triunfo
authors.forename: Renato
authors.initials: R
authors.lastname: Robledo
authors.forename: Antoniettina
authors.initials: A
authors.lastname: Rinaldi
authors.forename: Licinio
authors.initials: L
authors.lastname: Contu
authors.forename: Marcello
authors.initials: M
authors.lastname: Siniscalco
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*