title: Long-term home parenteral nutrition in children with chronic intestinal failure: A 15-year experience at a single Italian centre.
abstract: OBJECTIVE
  Chronic intestinal failure is a condition causing severe impairment of intestinal functions; long-term total parenteral nutrition is required to provide adequate nutritional support.
  
  
  METHODS
  This is a 15-year follow-up study of paediatric patients with intestinal failure receiving long-term home parenteral nutrition.
  
  
  RESULTS
  Thirty-six patients were included in the study, all aged <16 years. Total parenteral nutrition and home parenteral nutrition were administered respectively to 100.97 and 85.20 patients-year. Today, 12 out of 36 patients are still on parenteral nutrition. A total of 99 central venous catheters were inserted, for mean 2.75 catheters/patient. The overall incidence rates of catheter-related complications was 1.79 per 1000 days-catheter for sepsis and 3.37 per 1000 days-catheter for mechanical complications. Two multivariate Cox-models have been used to examine the role of some predictors for septic or mechanical complications. The only risk factor for septic complications was the indication for parenteral nutrition, and the only predictor of mechanical complications was the insertion period.
  
  
  CONCLUSIONS
  Our experience in the treatment of paediatric patients with gastrointestinal diseases confirms that long-term parenteral nutrition has become a safe and appropriate method in the treatment of severe chronic intestinal failure.
authors.affiliation: G. Gaslini Institute, Genova, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gandullia
authors.forename: Francesca
authors.initials: F
authors.lastname: Lugani
authors.forename: Laura
authors.initials: L
authors.lastname: Costabello
authors.forename: Serena
authors.initials: S
authors.lastname: Arrigo
authors.forename: Angela
authors.initials: A
authors.lastname: Calvi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Castellano
authors.forename: Silvia
authors.initials: S
authors.lastname: Vignola
authors.forename: Angela
authors.initials: A
authors.lastname: Pistorio
authors.forename: Arrigo V
authors.initials: AV
authors.lastname: Barabino
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004868:Equipment Failure / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007410:Intestinal Diseases / Q000628:therapy*; D007558:Italy; D008297:Male; D015999:Multivariate Analysis; D016562:Parenteral Nutrition, Home Total / Q000009:adverse effects* / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology / Q000209:etiology*