title: Clickable peptide nucleic acids (cPNA) with tunable affinity.
abstract: Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a "click" cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments.
authors.affiliation: Institut de Science et Ingénierie Supramoléculaires (ISIS-UMR 7006)Université de Strasbourg-CNRS, 8 allée Gaspard Monge, F67000 Strasbourg, France.
authors.forename: Dalila
authors.initials: D
authors.lastname: Chouikhi
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D003500:Cyclization; D004247:DNA / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D020135:Peptide Nucleic Acids; D014230:Triazoles; D004247:DNA