Inhibiting breast cancer progression by exploiting TGFbeta signaling.
Transforming Growth Factor beta (TGFbeta) signaling influences most aspects of cellular function in addition to playing a major role in organ development, remodeling, and repair. Given the wide range of effects induced by TGFbeta, it is not surprising that alterations in TGFbeta signaling have been implicated in development and progression of many different cancer types. Within the context of breast cancer itself, TGFbeta is known to have a dual nature, being both tumor-suppressive during early breast cancer development and tumor-promoting during breast cancer metastasis. Targets for breast cancer therapeutics are greatly needed to decrease morbidity and mortality from this devastating disease. Here, we summarize what is known about TGFbeta in breast cancer progression and discuss potential TGFbeta targets for breast cancer therapeutics.
Baxley
Sarah E
SE
Department of Cell Biology, University of Alabama at Birmingham, 1918 University Blvd. 660 MCLM, Birmingham, AL 35294-0005, USA.
Serra
Rosa
R
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D058990:Molecular Targeted Therapy; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D016212:Transforming Growth Factor beta