title: [Prosthetic valve thrombosis in a patient with antiphospholipid syndrome. Report of one case].
abstract: Primary antiphospholipid syndrome (APS) is a thrombophilic disorder not associated with connective tissue diseases or with autoimmune diseases. We report a 39-year-old female with a mechanical prosthetic mitral valve and a primary antiphospholipid syndrome. Anticoagulation with warfarin was changed for tinzaparine. Four days after the change, the patients was admitted in cardiogenic shock. A transesophageal echocardiogram showed a mass in the prosthetic valve suggestive of prosthetic thrombosis. The patient required two valve replacements due to thrombosis. Her anticardiolipin antibody titers were 84 UPL. She was discharged with a coagulation international normalized ratio of three.
authors.affiliation: Servicio de Cuidados Críticos y Urgencias, Hospital Universitario Virgen de las Nieves, Granada, España. menduina@terra.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Alaminos García
authors.forename: Manuel Jesús
authors.initials: MJ
authors.lastname: Menduiña G
authors.forename: Rafael
authors.initials: R
authors.lastname: De La Chica Ruiz-Ruano
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D013927:Thrombosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy