Familial prevalence of celiac disease.
OBJECTIVE
Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening.


METHODS
A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.


RESULTS
A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.


CONCLUSIONS
Family members of CD cases represent potential cases of CD.
Thapa
Babu Ram
BR
Division of Pediatric Gastroenterology Hepatology and Nutrition, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. brthapa1@yahoo.co.in
Rawal
Pawan
P
Sapra
Bharat
B
Vaiphei
Kim
K
Nain
Chander Kanwal
CK
Singh
Kartar
K
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004384:Duodenoscopy; D004386:Duodenum / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005190:Family; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D020022:Genetic Predisposition to Disease; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007194:India / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult
D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases