title: Support vector machines in DSC-based glioma imaging: suggestions for optimal characterization.
abstract: Dynamic susceptibility contrast magnetic resonance perfusion imaging (DSC-MRI) is a useful method to characterize gliomas. Recently, support vector machines (SVMs) have been introduced as means to prospectively characterize new patients based on information from previous patients. Based on features derived from automatically segmented tumor volumes from 101 DSC-MR examinations, four different SVM models were compared. All SVM models achieved high prediction accuracies (>82%) after rebalancing the training data sets to equal amounts of samples per class. Best discrimination was obtained using a SVM model with a radial basis function kernel. A correct prediction of low-grade glioma was obtained at 83% (true positive rate) and for high-grade glioma at 91% (true negative rate) on the independent test data set. In conclusion, the combination of automated tumor segmentation followed by SVM classification is feasible. Thereby, a powerful tool is available to characterize glioma presurgically in patients.
authors.affiliation: Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. frank.zoellner@medma.uni-heidelberg.de
authors.forename: Frank G
authors.initials: FG
authors.lastname: Zöllner
authors.forename: Kyrre E
authors.initials: KE
authors.lastname: Emblem
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Schad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001185:Artificial Intelligence; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D005260:Female; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult