Atypical Alzheimer's disease: a case report.
This paper deals with an unusual case of Alzheimer's disease with early onset, no family history, myoclonus, tonic generalized seizures and pseudo-periodic spikes on EEG. The demise occurred after 8 years of progressive cognitive deterioration; the pathological examination showed "Pick-like" atrophy, neurofibrillary tangles, senile plaques, congophilic angiopathy and cerebellar amyloid plaques. The genetical research could not support the hypothesis of a mutation of Presenilin 1 and 2 genes. Anyway, the peculiarity of the phenotype is worthy to be described even in the absence of specific molecular findings.
Iemolo
Francesco
F
Department of Neurology, Hospital R.Guzzardi, Vittoria, Ragusa, Italy.
Cavallaro
Tiziana
T
Rizzuto
Nicolò
N
D000328:Adult; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology; D058225:Plaque, Amyloid / Q000209:etiology; D015898:Tomography Scanners, X-Ray Computed