title: Low-dose dobutamine stress echocardiography to assess left ventricular contractile reserve for cardiac resynchronization therapy: data from the Low-Dose Dobutamine Stress Echocardiography to Predict Cardiac Resynchronization Therapy Response (LODO-CRT) trial.
abstract: Cardiac resynchronization therapy (CRT) is an effective methodology indicated in selected heart failure patients. Identifying responders to the therapy is still challenging. Most studies report that at least 30% of the patients are nonresponders. Baseline characteristics of the Low-Dose Dobutamine Stress Echocardiography to Predict Cardiac Resynchronization Therapy Response (LODO-CRT) trial population are presented. The study investigates dobutamine stress echocardiography's role in predicting CRT response. Two hundred seventy-one CRT candidates were studied. Mean age was 67+/-10 years, 69% were male, 96% had New York Heart Association class III disease, and 39% had heart failure of ischemic etiology. Mean QRS and left ventricular ejection fraction were 146+/-24 ms and 26%+/-6%, respectively. Seventy-seven percent of participants showed contractile reserve. Left ventricular end-diastolic volume was shown to be independently associated with contractile reserve presence. In particular, more dilated ventricles are associated with a lower chance of having contractile reserve. The LODO-CRT trial enrolled a cohort of patients fulfilling criteria for CRT. Dobutamine stress echocardiography was highly feasible and safe in this population. Contractile reserve was associated with healthier ventricles.
authors.affiliation: Sant'Anna Hospital, Catanzaro, Italy. iacopino@iol.it
authors.forename: Saverio
authors.initials: S
authors.lastname: Iacopino
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gasparini
authors.forename: Francesco
authors.initials: F
authors.lastname: Zanon
authors.forename: Cosimo
authors.initials: C
authors.lastname: Dicandia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Distefano
authors.forename: Antonio
authors.initials: A
authors.lastname: Curnis
authors.forename: Roberto
authors.initials: R
authors.lastname: Donati
authors.forename: Carlo P
authors.initials: CP
authors.lastname: Neja
authors.forename: Valeria
authors.initials: V
authors.lastname: Calvi
authors.forename: Mario
authors.initials: M
authors.lastname: Davinelli
authors.forename: Vanessa
authors.initials: V
authors.lastname: Novelli
authors.forename: Carmine
authors.initials: C
authors.lastname: Muto
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D015331:Cohort Studies; D016001:Confidence Intervals; D025401:Echocardiography, Stress; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000473:pathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009200:Myocardial Contraction; D016017:Odds Ratio; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D013318:Stroke Volume; D016277:Ventricular Function, Left