Decline of bone marrow-derived hematopoietic progenitor cell quality during aging in the rat.
Several studies have shown that aging is associated with quantitative and qualitative alterations of the stem and progenitor cell compartment. The current results indicate that there is a significant age-associated decline in the proliferative capacity of rat myeloid progenitor cells. In contrast, no difference was found in the frequency of myeloid progenitor cells in the bone marrow of young versus old rats. Furthermore, a significant shift towards higher proliferative capacity of myeloid progenitors was observed after lifelong voluntary exercise. These data emphasize that aging is accompanied by a loss of proliferative capacity and that voluntary exercise could retard this process.
Stelzer
Ingeborg
I
Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.
Fuchs
Robert
R
Schraml
Elisabeth
E
Quan
Ping
P
Hansalik
Michaela
M
Pietschmann
Peter
P
Quehenberger
Franz
F
Skalicky
Monika
M
Viidik
Andrus
A
Schauenstein
Konrad
K
D000375:Aging / Q000502:physiology*; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D002452:Cell Count; D049109:Cell Proliferation; D002469:Cell Separation; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D023461:Myeloid Progenitor Cells / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D016178:Granulocyte-Macrophage Colony-Stimulating Factor