Cohesin: a global player in chromosome biology with local ties to gene regulation.
Cohesin complexes hold sister chromatids together, which is essential for proper chromosome segregation during cell division and for post-replicative DNA repair. Recent studies suggest that, in addition to this global role in chromosome biology, cohesin is recruited to specific chromosomal locations by CTCF, and perhaps by other sequence-specific DNA binding factors. Once in position, cohesin controls chromosome conformation at the local level. Could this be key to understanding cohesin's role in gene expression?
Merkenschlager
Matthias
M
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK. matthias.merkenschlager@csc.mrc.ac.uk
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division; D002842:Chromatids / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D020090:Chromosome Segregation; D004260:DNA Repair; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000097722:Cohesins