Successful treatment of Balamuthia mandrillaris amoebic infection with extensive neurological and cutaneous involvement.
Granulomatous amoebic encephalitis caused by Balamuthia mandrillaris is an uncommon infection for which there is no optimal therapy. We describe a young, female patient who presented with extensive cutaneous and neurological involvement and who recovered after receiving prolonged treatment with miltefosine, fluconazole, and albendazole.
Martínez
Dalila Y
DY
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru. dalmaext@gmail.com
Seas
Carlos
C
Bravo
Francisco
F
Legua
Pedro
P
Ramos
Cesar
C
Cabello
Alfonso M
AM
Gotuzzo
Eduardo
E
D000328:Adult; D000368:Aged; D015766:Albendazole / Q000627:therapeutic use; D000562:Amebiasis / Q000188:drug therapy* / Q000469:parasitology* / Q000473:pathology; D056894:Amoebozoa / Q000145:classification / Q000302:isolation & purification*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006651:Histocytochemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011859:Radiography; D012876:Skin Diseases, Parasitic / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D015725:Fluconazole; D015766:Albendazole