title: Reactive arthritis and other musculoskeletal sequelae following an outbreak of Salmonella hadar in Castellon, Spain.
abstract: OBJECTIVE
  In 2005 a large outbreak of Salmonella hadar occurred in Spain following the consumption of commercial precooked roast chicken. We estimated the incidence and risk factors for reactive arthritis (ReA) and other musculoskeletal sequelae in the patients of this outbreak in 2 health departments of Castellon province.
  
  
  METHODS
  A prospective cohort study of the patients and their families was carried out. Clinical infection with Salmonella was considered as the exposure factor. The cohort was studied for ReA symptoms using a telephone questionnaire. Telephone interviews or medical examinations of subjects with musculoskeletal symptoms were conducted by a rheumatologist. Robust Poisson regression models were used in the analysis.
  
  
  RESULTS
  From the cohort of 262 people, 248 (94.7%) participated in the telephone survey, 155 with clinical salmonellosis (infected), 78 noninfected, and 15 with some symptoms but not clinical salmonellosis. One hundred one infected patients (65%) reported musculoskeletal symptoms, compared to 19 noninfected (24%) (adjusted relative risk = 2.60, 95% CI 1.73-3.90). Of the infected group, 16 ReA (incidence 10%, 95% CI 6.0-16.2), 7 enthesopathies, and 2 arthralgias were detected, and zero in the noninfected group. The risk factors for ReA were age, weight loss, and duration of diarrhea. Antibiotic treatment for the infection protected against symptoms of peripheral or axial arthritis (adjusted relative risk = 0.73, 95% CI 0.55-0.98).
  
  
  CONCLUSIONS
  The incidence of ReA and musculoskeletal symptoms after the infection was high. The use of antibiotics for S. hadar infection offered some protection against musculoskeletal symptoms.
authors.affiliation: Epidemiology Division, Public Health Center, Castellón, Spain. arnedo_alb@gva.es
authors.forename: Alberto
authors.initials: A
authors.lastname: Arnedo-Pena
authors.forename: Juan
authors.initials: J
authors.lastname: Beltrán-Fabregat
authors.forename: Bartolomé
authors.initials: B
authors.lastname: Vila-Pastor
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Tirado-Balaguer
authors.forename: Concepción
authors.initials: C
authors.lastname: Herrero-Carot
authors.forename: Juan Bautista
authors.initials: JB
authors.lastname: Bellido-Blasco
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Romeu-Garcia
authors.forename: Lourdes
authors.initials: L
authors.lastname: Safont-Adsuara
authors.forename: Maria Rosario
authors.initials: MR
authors.lastname: Pac-Sa
authors.forename: Francisco
authors.initials: F
authors.lastname: Guillen-Grima
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016918:Arthritis, Reactive / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D002645:Chickens; D015331:Cohort Studies; D003296:Cooking; D003625:Data Collection; D004196:Disease Outbreaks; D005506:Food Contamination; D005516:Food Microbiology; D006801:Humans; D008297:Male; D009220:Myositis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D000091402:Prohibitins; D011446:Prospective Studies; D012478:Salmonella Food Poisoning / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D012477:Salmonella enteritidis / Q000302:isolation & purification* / Q000502:physiology; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013689:Telephone
chemical_list: D000900:Anti-Bacterial Agents; C000717331:PHB2 protein, human; D000091402:Prohibitins