Differential signaling circuits in regulation of ultraviolet C light-induced early- and late-phase activation of NF-κB.
Ultraviolet C light (UVC) induces nuclear factor-kappa B (NF-κB) activation via a complex network. In the early phase (4-12 h) of irradiation, NF-κB activation is accompanied with IκBα reduction via a translation inhibition pathway. In the late phase of UVC-induced NF-κB activation (16-24 h), the IκBα depletion is a combined result of regulation at both transcriptional and translational levels. However, the NF-κB activation appears to be independent of the level of IκBα. In this review, we will discuss the multiple signaling circuits that regulate NF-κB activation during the early and late phases of UVC irradiation.
Wu
Shiyong
S
Department of Chemistry and Biochemistry, Edison Biotechnology Institute and Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA. wus1@ohio.edu
Tong
Lingying
L
D000818:Animals; D005786:Gene Expression Regulation / Q000528:radiation effects*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D014466:Ultraviolet Rays
D016328:NF-kappa B