Impact of restraint and disinhibition on PYY plasma levels and subjective feelings of appetite.
The impact of eating behaviours on circulating levels of appetite-regulating hormones remains largely unknown. The aims of this study were to assess the role of restraint and disinhibition on fasting/postprandial peptide YY (PYY) plasma levels and subjective feelings of appetite in normal-weight individuals and to determine whether the effect was energy load dependent. 33 participants (12 men) were classified as restrained/unrestrained and low/high in disinhibition based on Three Factor Eating Questionnaire-18R and Dutch Eating Behaviour Questionnaire. The impact of restraint/disinhibition on PYY plasma levels and feelings of appetite was measured, after a 500kcal and 1000kcal breakfast, using a randomised crossover design. Restraint did not impact on either fasting or postprandial PYY plasma levels, but participants with high disinhibition had a tendency towards a blunted postprandial PYY response. Moreover, restrained eaters reported lower ratings of prospective food consumption postprandially, and a tendency towards higher fullness/lower hunger. In conclusion, circulating PYY is unaffected by restrained eating behaviour, despite being associated with increased fullness and reduced hunger in the fed state. High levels of disinhibition tend to be associated with a blunted PYY response and this may contribute towards the susceptibility to overconsumption and increased risk of weight gain characteristic of this trait.
Martins
C
C
Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK. catia.martins@ntnu.no
Robertson
M D
MD
Morgan
L M
LM
D000328:Adult; D001066:Appetite / Q000502:physiology*; D018592:Cross-Over Studies; D002149:Energy Intake / Q000502:physiology*; D005215:Fasting / Q000378:metabolism; D005247:Feeding Behavior; D005260:Female; D054439:Ghrelin / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D019894:Peptide YY / Q000097:blood* / Q000378:metabolism; D019518:Postprandial Period / Q000502:physiology; D055815:Young Adult
D054439:Ghrelin; D019894:Peptide YY