title: Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate.
abstract: The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (k(r) > 10(9) M(-1)s(-1)) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy.
authors.affiliation: Dip. Chimica Organica, Università di Pavia, viale Taramelli 10, 27100, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Fasani
authors.forename: Ilse
authors.initials: I
authors.lastname: Manet
authors.forename: Massimo L
authors.initials: ML
authors.lastname: Capobianco
authors.forename: Sandra
authors.initials: S
authors.lastname: Monti
authors.forename: Luca
authors.initials: L
authors.lastname: Pretali
authors.forename: Angelo
authors.initials: A
authors.lastname: Albini
mesh_terms: D024841:Fluoroquinolones / Q000138:chemical synthesis*; D006157:Guanosine Monophosphate / Q000737:chemistry*; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis*
chemical_list: D024841:Fluoroquinolones; D017319:Photosensitizing Agents; D006157:Guanosine Monophosphate