title: Oxycellulose as mucoadhesive polymer in buccal tablets.
abstract: BACKGROUND
  Oxycellulose (OC) is biodegradable and bioabsorbable cellulose derivative used in medicine to support hemostasis and tissue healing. Recently, its antimicrobial and immunomodulating properties, as well as its potential in modern therapeutic systems as release modifying excipient, drug carrier, and/or mucoadhesive polymer, are widely discussed.
  
  
  METHODS
  To study its last-mentioned characteristics, directly compressed tablets containing 5 mg of cetylpyridinium chloride (CPC) as a model drug and 90 mg of mucoadhesive polymer [oxycellulose sodium (NaOC) alone or in a combination with one of five widely used mucoadhesive polymers] were prepared to ensure 8 hours prolonged release of CPC. Physicochemical and mucoadhesive properties of prepared tablets were evaluated.
  
  
  RESULTS
  Based on obtained results, tablets containing OC in combination with hydroxypropylmethylcellulose (Methocel K100LV) or carboxymethylcellulose sodium showed the best quality parameters (friability < 0.04%, tablet thickness < 2.17 mm, tablet hardness > 85 N, residence time > 256 minutes, mucoadhesive strength > 3.45 mN/mm(2) ) and dissolution profiles (more than 81% of CPC released within 8 hours).
  
  
  CONCLUSIONS
  NaOC embodies excellent compressing, mechanical, and mucoadhesive properties; however, formulation with higher content of NaOC only showed shorter adhesion time (107 +/- 7 minutes) and faster drug release (93.66% of CPC released within 2 hours), because of its good solubility in aqueous media.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. gajdziokj@vfu.cz
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
authors.forename: Martina
authors.initials: M
authors.lastname: Bajerová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Chalupová
authors.forename: Miloslava
authors.initials: M
authors.lastname: Rabisková
mesh_terms: D000268:Adhesiveness; D000278:Administration, Buccal; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000737:chemistry*; D002594:Cetylpyridinium / Q000737:chemistry*; D002610:Cheek; D004337:Drug Carriers; D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D009061:Mouth Mucosa; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D014783:Viscosity
chemical_list: D000891:Anti-Infective Agents, Local; D004337:Drug Carriers; D005079:Excipients; D011108:Polymers; D013607:Tablets; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D002594:Cetylpyridinium