[Non-syndromic cleft lip/cleft palate and C677T methylene-tetrahydrofolate reductase variant in Mexican children].
BACKGROUND
Non-syndromic cleft lip with or without cleft palate (NSCLP) is a common malformation. The aetiology is multifactorial. An incidence of 1.1-1.39 per 1000 new births had been reported in Mexico. The folic acid intake in preconceptional stage has been reported to prevent malformations such as neural tube defects (NTD) and NSCLP. The C677T variant of the methylene-tetrahydrofolate reductase (MTHFR) gene is responsible of a thermolabile form, related to decrease of folate and increase homocysteine. This variant has been associated with CLP, in different populations, but results are still controversial. Our objective was to determine the allelic (AF) and genotypic frequency (GF) of the MTHFR-C677T variant in Mexican children with NSCLP.


METHODS
Transverse comparative study in 67 Mexican children with NSCLP and a control group with 70 unrelated Mexican individuals without NSCLP.


RESULTS
The AF in NSCLP was 39 %. There was no statistical difference between AF in the two groups (39 versus 41).


CONCLUSIONS
In this population, genotype C677T was not a major risk factor for this malformation, however, sample size, other genes implicated and genes-environment interactions must be considered.
Dávalos-Rodríguez
Ingrid Patricia
IP
Centro de Investigación Biomédica de Occidente, Universidad de Guadalajara, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. ingriddavalos@hotmail.com
Ramírez-Lizardo
Ernesto Javier
EJ
Mena
Juan Pablo
JP
Ledezma-Rodríguez
Víctor
V
Omayra-Dávalos
Nory
N
González-Mercado
Mirna Gisel
MG
Durán-González
Jorge
J
Morán-Moguel
María Cristina
MC
Peralta-Leal
Valeria
V
Salazar-Páramo
Mario
M
Ledezma-Gómez
Víctor
V
D002648:Child; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D003430:Cross-Sectional Studies; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico
D042965:Methylenetetrahydrofolate Reductase (NADPH2)