Room temperature, copper-catalyzed amination of bromonaphthyridines with aqueous ammonia.
Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu(2)O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.
Anderson
Cyrus A
CA
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA.
Taylor
Phillip G
PG
Zeller
Mary A
MA
Zimmerman
Steven C
SC