Evidence obtained from ANOVA to reason cross-species infection and cross-subtype mutation in neuraminidases of influenza A viruses.
The current pandemic of A/H1N1 influenza raises a serious question on cross-species infection and cross-subtype mutation because our previous focus on possible influenza pandemic laid on H5N1 subtype and the cross-species infection between avian and human. In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross-species barrier in some species, and the intra-species variation is larger than the inter-species variation in some species hosting the viruses, and the cross-subtype mutation is possible because there is no cross-subtype barrier in some subtypes and the intra-subtype variation is larger than the inter-subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.
Yan
S
S
National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, China.
Wu
G
G
D000704:Analysis of Variance; D000818:Animals; D014644:Genetic Variation; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000201:enzymology* / Q000235:genetics*; D007251:Influenza, Human / Q000821:virology*; D009439:Neuraminidase / Q000235:genetics*; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D058873:Pandemics; D013045:Species Specificity; D015047:Zoonoses
D009439:Neuraminidase