title: What is new in HIV/AIDS research in developing countries?
abstract: HIV epidemic has had greatest impact in sub-Saharan Africa (SSA) and mainly in East and Southern Africa with HIV prevalence in some parts going up to 30%. In the recent years, considerable HIV research on prevention, treatment and care, and vaccine has been conducted in many developing countries and provided evidence-based knowledge to control the epidemic. However, there have also been disappointing results in HIV prevention trials such as in HIV vaccine and microbicide trials. Despite these outcomes, important lessons have been learnt that help in designing future trials. This article examines the recent advances in HIV research in developing countries. The most recent HIV prevention research has demonstrated the effect of male circumcision on HIV acquisition, and lack of impact of HSV-2 treatment on HIV transmission and acquisition. Use of HIV antiretroviral drugs (ARVs) for HIV prevention is a new area that has attracted interest and a number of trials are examining the effect of oral Pre-Exposure Prophylaxis on HIV acquisition and also looking at the potential of ARVs in reducing infectiousness. Progress has been made in HIV treatment, monitoring treatment efficacy and toxicity as well as evaluation of different models of ART delivery. HIV vaccine research has, however, faced most challenges despite many efforts that have been put in. Looking into the future, there are ongoing trials that will hopefully generate important information to strengthen HIV policies in the next few years. There are, however, many other gaps in HIV research that need to be urgently addressed.
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda. anatoli.kamali@mrcuganda.org
authors.forename: Anatoli
authors.initials: A
authors.lastname: Kamali
mesh_terms: D016915:AIDS Vaccines; D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control; D019380:Anti-HIV Agents / Q000627:therapeutic use; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D003906:Developing Countries; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D006801:Humans
chemical_list: D016915:AIDS Vaccines; D019380:Anti-HIV Agents