title: Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism.
abstract: Triggering of phagocyte apoptosis is a major virulence mechanism used by some successful bacterial pathogens. A central issue in the apoptotic death context is that fully developed apoptosis results in necrotic cell autolysis (secondary necrosis) with release of harmful cell components. In multicellular animals, this occurs when apoptosing cells are not removed by scavengers, mainly macrophages. Secondary necrotic lysis of neutrophils and macrophages may occur in infection when extensive phagocyte apoptosis is induced by bacterial cytotoxins and removal of apoptosing phagocytes is defective because the apoptotic process exceeds the available scavenging capacity or targets macrophages directly. Induction of phagocyte secondary necrosis is an important pathogenic mechanism, as it combines the pathogen evasion from phagocyte antimicrobial activities and the release of highly cytotoxic molecules, particularly of neutrophil origin, such as neutrophil elastase. This pathogenicity mechanism therefore promotes the unrestricted multiplication of the pathogen and contributes directly to the pathology of several necrotizing infections, where extensive apoptosis and necrosis of macrophages and neutrophils are present. Here, examples of necrotizing infectious diseases, where phagocyte secondary necrosis is implicated, are reviewed.
authors.affiliation: Instituto de Biologia Molecular e Celular, University of Porto, Rua do Campo Alegre 823, Porto, Portugal. mtsilva@ibmc.up.pt
authors.forename: Manuel T
authors.initials: MT
authors.lastname: Silva
mesh_terms: D000818:Animals; D017209:Apoptosis; D001329:Autolysis; D001424:Bacterial Infections / Q000473:pathology*; D001492:Bass; D009336:Necrosis / Q000473:pathology*; D010586:Phagocytes / Q000382:microbiology / Q000473:pathology*; D010587:Phagocytosis; D015398:Signal Transduction; D014774:Virulence