title: Hypolipidaemic & hepatoprotective effects of Psidium guajava raw fruit peel in experimental diabetes.
abstract: OBJECTIVE
  The study evaluated the hypolipidaemic and hepatoprotective effects of unripe Psidium guajava fruit peel aqueous extract in streptozotocin (STZ) induced severely diabetic rats by assaying their triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) cholesterol, alkaline phosphatase (ALKP), asperate amino transeferase (AST), alanine amino transferase (ALT) and creatanine (CRTN) levels.
  
  
  METHODS
  Severely diabetic albino Wister rats of same age group were treated orally once a day upto 3wk with a dose of 400 mg/kg bw of lyophilized extract. TG, TC, HDL, ALKP, AST, ALT and CRTN were estimated. LDL and VLDL cholesterol levels were calculated from the above measurements by using Friedwald formula.
  
  
  RESULTS
  A significant decrease in TG (P<0.01), TC (P<0.01), HDL (P<0.001) VLDL (P<0.001) and LDL (P<0.01), ALKP (P<0.01), AST (P<0.05), ALT (P<0.05) and CRTN (P<0.001) levels were observed after 21 days treatment of aquous extract of raw fruit peel compared to pre treatment levels.
  
  
  CONCLUSIONS
  The extract showed significant hypolipidaemic activity in addition to its hypoglycaemic and antidiabetic activity. In view of its relative non-toxic nature P. guajava raw fruit peel may be a potential antidiabetic agent.
authors.affiliation: Department of Chemistry, University of Allahabad, Allahabad, India.
authors.forename: Prashant Kumar
authors.initials: PK
authors.lastname: Rai
authors.forename: Shikha
authors.initials: S
authors.lastname: Mehta
authors.forename: Geeta
authors.initials: G
authors.lastname: Watal
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005638:Fruit / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism*; D010936:Plant Extracts / Q000627:therapeutic use*; D031647:Psidium / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D014044:Tolbutamide / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol; D014044:Tolbutamide