title: Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study.
abstract: We performed a single-arm, open-label pilot trial of the anti-inflammatory drug pentoxifylline to reduce systemic inflammation and improve endothelial function, measured by flow-mediated dilation of the brachial artery, in HIV-infected patients not requiring antiretroviral therapy. Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferon-gamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway.
authors.affiliation: Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA. sgupta1@iupui.edu <sgupta1@iupui.edu>
authors.forename: Samir K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Johnson
authors.forename: Kieren J
authors.initials: KJ
authors.lastname: Mather
authors.forename: Matthias
authors.initials: M
authors.lastname: Clauss
authors.forename: Jalees
authors.initials: J
authors.lastname: Rehman
authors.forename: Chandan
authors.initials: C
authors.lastname: Saha
authors.forename: Zeruesenay
authors.initials: Z
authors.lastname: Desta
authors.forename: Michael P
authors.initials: MP
authors.lastname: Dubé
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001916:Brachial Artery / Q000187:drug effects / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D010431:Pentoxifylline