title: Multiple sclerosis and vitamin D: a review and recommendations.
abstract: A relationship between vitamin D and several diseases, including multiple sclerosis (MS), has recently received interest in the scientific community. Vitamin D appears to have important actions beyond endocrine function, particularly for the immune system. Risk of development of MS, as well as disease severity, has been associated with vitamin D in a variety of studies. There remains a need for prospective studies to further establish this relationship. Given the current evidence of the potential benefits of vitamin D, it appears to be reasonable and safe to consider vitamin D supplementation at dosing adequate to achieve normal levels in patients with MS and clinically isolated syndrome.
authors.affiliation: Department of Neurology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, CR 120, Portland, OR 97239, USA. solomoan@ohsu.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Solomon
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Whitham
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009103:Multiple Sclerosis / Q000178:diet therapy* / Q000276:immunology / Q000378:metabolism*; D012727:Sex Characteristics; D014807:Vitamin D / Q000008:administration & dosage / Q000502:physiology*
chemical_list: D014807:Vitamin D