title: Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
abstract: Fifteen Amaryllidaceae alkaloids (1-15) were evaluated for their antiproliferative activities against six distinct cancer cell lines. Several of these natural products were found to have low micromolar antiproliferative potencies. The log P values of these compounds did not influence their observed activity. When active, the compounds displayed cytostatic, not cytotoxic activity, with the exception of pseudolycorine (3), which exhibited cytotoxic profiles. The active compounds showed similar efficacies toward cancer cells irrespective of whether the cell lines were responsive or resistant to proapoptotic stimuli. Altogether, the data from the present study revealed that lycorine (1), amarbellisine (6), haemanthamine (14), and haemanthidine (15) are potentially useful chemical scaffolds to generate further compounds to combat cancers associated with poor prognoses, especially those naturally resistant to apoptosis, such as glioblastoma, melanoma, non-small-cell lung, and metastatic cancers.
authors.affiliation: Laboratoire de Toxicologie and Laboratoire de Chimie Analytique, Toxicologie et Chimie Physique Appliquee, Institut de Pharmacie, Universite Libre de Bruxelles, Brussels, Belgium.
authors.forename: Gwendoline
authors.initials: G
authors.lastname: Van Goietsenoven
authors.forename: Anna
authors.initials: A
authors.lastname: Andolfi
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lallemand
authors.forename: Alessio
authors.initials: A
authors.lastname: Cimmino
authors.forename: Delphine
authors.initials: D
authors.lastname: Lamoral-Theys
authors.forename: Thierry
authors.initials: T
authors.lastname: Gras
authors.forename: Amina
authors.initials: A
authors.lastname: Abou-Donia
authors.forename: Jacques
authors.initials: J
authors.lastname: Dubois
authors.forename: Florence
authors.initials: F
authors.lastname: Lefranc
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Antonio
authors.initials: A
authors.lastname: Evidente
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010617:Phenanthridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010617:Phenanthridines; C027861:pseudolycorine; C083906:hemanthidine; C462104:hemanthamine; C015330:lycorine