title: Steroidal saponins from two species of Dracaena.
abstract: Four new steroidal saponins (1-4) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) from D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 1-4 were established as diosgenin 3-O-[3-O-sulfate-alpha-l-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranoside (1), 1-O-beta-d-xylopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->3)]-beta-d-fucopyranosyl(23S,24S)-spirosta-5,25(27)-diene-1beta,3beta,23alpha,24alpha-tetrol 24-O-alpha-l-arabinopyranoside (2), pennogenin-3-O-alpha-l-rhamnopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->3)]-[6-O-acetyl]-beta-d-glucopyranoside (3), and 24alpha-hydroxypennogenin 3-O-alpha-l-rhamnopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->3)]-beta-d-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
authors.affiliation: Laboratoire de Pharmacognosie, Unite de Molecules d'Interet Biologique, UMIB UPRES-EA 3660, Faculte de Pharmacie, Universite de Bourgogne, 7 Boulevard Jeanne d'Arc, Dijon Cedex, France.
authors.forename: Guy Beddos
authors.initials: GB
authors.lastname: Kougan
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Chiaki
authors.initials: C
authors.lastname: Tanaka
authors.forename: Thomas
authors.initials: T
authors.lastname: Paululat
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mirjolet
authors.forename: Olivier
authors.initials: O
authors.lastname: Duchamp
authors.forename: Beibam Lucas
authors.initials: BL
authors.lastname: Sondengam
authors.forename: Marie-Aleth
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D002163:Cameroon; D031409:Dracaena / Q000737:chemistry*; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012503:Saponins; D013256:Steroids