title: Right ventricle-sparing left ventricular resection and replacement with a continuous-flow rotary blood pump: an in vivo experiment.
abstract: Despite recent advances in left ventricular assist device and total artificial heart technologies, these devices are still so large that they pose a significant problem in small patients with refractory heart failure. Excising the left ventricle while preserving the right ventricle--and then replacing the left ventricle with a mechanical pump--has been proposed as an alternative approach to this problem. We conducted a pilot study to evaluate possible surgical techniques and the hemodynamic effects of right ventricle-sparing left ventricular resection and replacement with a continuous-flow rotary blood pump in a healthy bovine model.
authors.affiliation: Cardiovascular Surgical Research Laboratories, Texas Heart Institute, St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. lschwenke@heart.thi.tmc.edu
authors.forename: O H
authors.initials: OH
authors.lastname: Frazier
authors.forename: Egemen
authors.initials: E
authors.lastname: Tuzun
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Narin
authors.forename: William E
authors.initials: WE
authors.lastname: Cohn
mesh_terms: D000818:Animals; D006348:Cardiac Surgical Procedures / Q000295:instrumentation*; D002417:Cattle; D006352:Heart Ventricles / Q000503:physiopathology / Q000601:surgery*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008422:Materials Testing; D023421:Models, Animal; D010865:Pilot Projects; D011474:Prosthesis Design; D013997:Time Factors; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right