title: Furostanol glycosides from the rhizomes of Helleborus orientalis.
abstract: Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 cells.
authors.affiliation: Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. mimakiy@toyaku.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Kazuki
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
mesh_terms: D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D039322:Helleborus; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification*; D027343:Rhizome
chemical_list: D006027:Glycosides; D010936:Plant Extracts