title: Unexpectedly high burden of rotavirus gastroenteritis in very young infants.
abstract: BACKGROUND
  The highest incidence of rotavirus gastroenteritis has generally been reported in children 6-24 months of age. Young infants are thought to be partially protected by maternal antibodies acquired transplacentally or via breast milk. The purpose of our study was to assess the age distribution of children with confirmed community-acquired rotavirus gastroenteritis presenting to an urban referral hospital.
  
  
  METHODS
  Children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the presence of rotavirus antigen in the stool by ELISA (followed by genotyping if ELISA-positive) since the 1994-95 epidemic season.
  
  
  RESULTS
  Over the last 12 rotavirus seasons prior to the introduction of the pentavalent rotavirus vaccine in 2006, stool specimens from 1646 patients tested positive for community-acquired rotavirus infection. Gender or age was not recorded in 6 and 5 cases, respectively. Overall, 58% of the cases occurred in boys. G1 was the predominant VP7 serotype, accounting for 72% of cases. The median (IQR) age was 11 (5-21) months. A total of 790 (48%) cases occurred in children outside the commonly quoted peak age range, with 27% in infants <6 months of age and 21% in children >24 months of age. A total of 220 (13%) cases occurred during the first 3 months of life, and the highest number of episodes per month of age [97 (6%)] was observed during the second month of life.
  
  
  CONCLUSIONS
  The incidence of community-acquired rotavirus gastroenteritis monitored over 12 seasons in the prevaccine era at a major university hospital was nearly constant for each month of age during the first year of life, revealing an unexpectedly high incidence of symptomatic rotavirus disease in infants <3 months old. A sizeable fraction of cases occurred in children too young to have been vaccinated according to current recommendations.
authors.affiliation: Division of Infectious Diseases, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. clarkf@email.chop.edu
authors.forename: H Fred
authors.initials: HF
authors.lastname: Clark
authors.forename: Amy E
authors.initials: AE
authors.lastname: Marcello
authors.forename: Diane
authors.initials: D
authors.lastname: Lawley
authors.forename: Megan
authors.initials: M
authors.lastname: Reilly
authors.forename: Mark J
authors.initials: MJ
authors.lastname: DiNubile
mesh_terms: D017714:Community-Acquired Infections / Q000453:epidemiology; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010414:Pennsylvania / Q000453:epidemiology; D012400:Rotavirus Infections / Q000175:diagnosis / Q000453:epidemiology*