title: Micro-computed tomographic assessment following extremely oversized partial postdilatation of drug-eluting stents.
abstract: To assess the spatial geometry of drug-eluting stents (DES) following extremely oversized proximal postdilatation. Interventions of distal left main (LM) disease generally require stenting across the LM bifurcation with inherent vessel tapering along this segment and a high likelihood of stent malapposition, which can be avoided by such postdilations.
  
  
  
  Sixteen DES (four 3.5 mm-samples of Cypher Select Plus, Taxus Liberté, Endeavor Resolute, Xience V) were deployed in water; 12 samples were then proximally postdilated with noncompliant 5.0 mm balloons at 18 atm. All samples were examined by micro-computed tomography. Taxus Liberté, Endeavor Resolute, and Xience V, showed increased cell areas in the transitional region (just distal to postdilated region), while Cypher Select showed its largest cells inside the postdilated region. Overall, the largest maximum cell area was observed in Endeavor Resolute, while Cypher Select showed the smallest (p<0.001, for both). In addition, the size of the very proximal postdilated cells was relatively small in most DES except Xience V.
  
  
  
  Extremely oversized partial stent postdilatation demonstrated significant between-DES differences in final spatial stent configuration and maximum cell size. These data could be of practical interest with regard to coronary interventions in LM stems with stenting across the LM bifurcation.
authors.affiliation: Department of Cardiology, Thoraxcentrum Twente, Enschede, The Netherlands.
authors.forename: Mounir W Z
authors.initials: MW
authors.lastname: Basalus
authors.forename: K Gert
authors.initials: KG
authors.lastname: van Houwelingen
authors.forename: Marc J K
authors.initials: MJ
authors.lastname: Ankone
authors.forename: Jan
authors.initials: J
authors.lastname: Feijen
authors.forename: Clemens
authors.initials: C
authors.lastname: von Birgelen
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D054855:Drug-Eluting Stents; D021621:Imaging, Three-Dimensional; D008422:Materials Testing; D011474:Prosthesis Design; D055114:X-Ray Microtomography