title: Extramammary paget disease of scrotum with oncocytic changes.
abstract: We report an unusual case of primary scrotal extramammary Paget disease that infiltrated reticular dermis and lymph vessels, with metastasis in inguinal lymph node. The 67-year-old patient died at 14 months due to systemic metastases. The tumor, which was located in epidermis and infiltrated the dermis, comprised cells with wide, granular, and eosinophilic cytoplasm and intense positivity for antimitochondrial antibody. This seems to be the first report of oncocytic changes in extramammary Paget disease.
authors.affiliation: Department of Pathology, University Hospital, Granada, Spain. janeiros@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Aneiros-Fernandez
authors.forename: S
authors.initials: S
authors.lastname: Arias-Santiago
authors.forename: H
authors.initials: H
authors.lastname: Husein-ElAhmed
authors.forename: Alina
authors.initials: A
authors.lastname: Nicolae
authors.forename: F O'valle
authors.initials: FO
authors.lastname: Ravassa
authors.forename: S
authors.initials: S
authors.lastname: Serrano-Ortega
authors.forename: F Nogales
authors.initials: FN
authors.lastname: Fernandez
authors.forename: J Aneiros
authors.initials: JA
authors.lastname: Cachaza
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D005834:Genital Neoplasms, Male / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010145:Paget Disease, Extramammary / Q000378:metabolism / Q000473:pathology*; D012611:Scrotum / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*