title: Engineered heart tissue: high throughput platform for dissection of complex diseases.
abstract: The polygenic nature of resistance/sensitivity of the heart to ischemia is generally accepted. Unfortunately, little is known about gene(s) involved in response to this insult. The goal of present study is to introduce new tool, engineered heart tissue (EHT), for accelerating positional cloning and for providing novel functional assays.
authors.affiliation: Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jlazar@mcw.edu
authors.forename: Jozef
authors.initials: J
authors.lastname: Lazar
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Jacob
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Wakatsuki
mesh_terms: D000818:Animals; D020296:Animals, Congenic; D003001:Cloning, Molecular / Q000379:methods; D005260:Female; D023281:Genomics; D057166:High-Throughput Screening Assays / Q000379:methods*; D008297:Male; D017202:Myocardial Ischemia / Q000235:genetics / Q000517:prevention & control*; D009206:Myocardium; D010641:Phenotype; D051381:Rats; D023822:Tissue Engineering; D014161:Transduction, Genetic