Single-unit umbilical cord blood transplantation from unrelated donors in adult patients with chronic myelogenous leukemia.
Clinical studies focused on outcomes of umbilical cord blood transplantation (UCBT) for patients with chronic myelogenous leukemia (CML) in need of allogeneic stem cell transplantation and lacking an HLA-matched adult donor are limited. We analyzed the outcome of 26 adults with CML receiving single-unit UCBT from unrelated donors after myeloablative conditioning at a single institution. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 7 patients (27%) were in first chronic phase (CP), 11 (42%) were in second CP, 2 (8%) were in accelerated phase (AP), and 6 (23%) were in blast crisis (BC). The cumulative incidence (CI) of myeloid engraftment was 88% at a median time of 22 days and was significantly better for patients receiving higher doses of CD34(+) cells. The CI of acute graft-versus-host disease (GVHD) grade II-IV was 61%, that of acute GVHD grade III-IV was 39%, and that of chronic extensive GVHD was 60%. Treatment-related mortality (TRM) was 41% for patients undergoing UCBT while in first or second CP and 100% for patients in AP or BC (P < .01). After a median follow-up of 8 years, none of the patients relapsed, giving an overall disease-free survival (DFS) at 8 years of 41%. The DFS for patients undergoing UCBT while in any CP was 59%. These results demonstrate that UCBT from unrelated donors can be a curative treatment for a substantial number of patients with CML. Advances in supportive care and better selection of cord blood units and patients are needed to improve TRM.
Sanz
Jaime
J
Department of Hematology, Hospital Universitario La Fe, Valencia, Spain. sanz_jai@gva.es
Montesinos
Pau
P
Saavedra
Silvana
S
Lorenzo
Ignacio
I
Senent
Leonor
L
Planelles
Dolores
D
Larrea
Luis
L
Martín
Guillermo
G
Palau
Javier
J
Jarque
Isidro
I
Martínez
Jesús
J
de la Rubia
Javier
J
Moscardó
Federico
F
Martinez
David
D
Gómez
Inés
I
López
María
M
Sanz
Miguel A
MA
Sanz
Guillermo F
GF
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002423:Cause of Death; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000453:epidemiology; D006648:Histocompatibility; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D010976:Platelet Count; D012008:Recurrence; D012189:Retrospective Studies; D018183:Transplantation Chimera; D016896:Treatment Outcome; D055815:Young Adult