A case of mesothelial/monocytic incidental cardiac excrescence and literature review.
Mesothelial/monocytic incidental cardiac excrescence (MICE) is a rare entity which is an amalgam of mesothelial cells, histiocytes, and fibrin, often found occasionally during cardiac valve replacement. We report a case in a 25-year-old Chinese female with serous mitral stenosis and patent foramen ovale. Routine and immunohistochemical stains and ultrastructure examination revealed the vegetation was predominantly composed of histocytes with scattered mesothelial cells. In fact nodular histiocytic/mesothelial hyperplasia (NHMH) is a similar lesion to MICE. MICE and NHMH could be unified, and NHMH may be a better choice.
Hu
Zhong-Liang
ZL
Department of Pathology, Xiangya Medical School, Central South University, Changsha, Hunan Province, China. pjo7858@hotmail.com
Lü
Hui
H
Yin
Hong-Ling
HL
Wen
Ji-Fang
JF
Jin
Ou
O
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D004848:Epithelium / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D005337:Fibrin / Q000032:analysis; D054092:Foramen Ovale, Patent / Q000150:complications; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008943:Mitral Valve / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D008946:Mitral Valve Stenosis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D009000:Monocytes / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D009626:Terminology as Topic
D015415:Biomarkers; D005337:Fibrin