title: MicroRNAs in cardiac remodeling and disease.
abstract: MicroRNAs (miRNAs) are a large sub-group of small non-coding RNAs, which have been demonstrated to post-transcriptionally regulate the expression of protein-coding genes in a wide-range biological process. miRNAs have been shown to be essential for normal heart development and cardiac function. Recent data suggest that miRNAs are involved in the etiology of cardiac disease and the remodeling of hearts, including cardiac hypertrophy, myocardial infarction, and cardiac arrhythmias. In this review, we focus on the recent progress in the understanding of the function of miRNAs in cardiac remodeling and disease. We will also discuss the diagnostic and therapeutic potential of miRNAs in heart disease.
authors.affiliation: Cardiovascular Research Division, Department of Cardiology, Children's Hospital Boston, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Zhan-Peng
authors.initials: ZP
authors.lastname: Huang
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Neppl
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D005819:Genetic Markers; D005820:Genetic Testing; D015316:Genetic Therapy; D006331:Heart Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs