title: Degradation Behavior of 3D Porous Polydioxanone-b-Polycaprolactone Scaffolds Fabricated Using the Melt-Molding Particulate-Leaching Method.
abstract: Recently, polydioxanone (PDO) and polycaprolactone (PCL) have been applied in applications for tissue engineering owing to their flexibility, as well as biocompatibility and biodegradability, even though their degradation rates are usually either too fast or too slow for many applications. In this study, we synthesized poly(dioxanone-b-caprolactone) co-polymers (PDOCLs) with different DO/CL ratio (0:10-10:0) by ring-opening polymerization. The synthesized co-polymers were characterized by (1)H-NMR, the measurement of inherent viscosity (IV), GPC and DSC. PDOCL scaffolds with different DO/CL ratio were fabricated by a melt-molding particulate-leaching method without using any organic solvents during the scaffold fabrication process. The degradation behavior (in vitro) of the PDOCL scaffolds was evaluated in PBS at 37°C for up to 56 days by the changes in molecular weight, mechanical strength, gross weight and pH. It was observed that the degradation rate of PDOCL scaffolds could be controlled by adjusting the DO/CL ratio of the co-polymers (increasing CL composition leads to slower degradation rate). The PDOCL scaffolds did not lead to a significant drop in pH during the degradation, not even for the PDO-dominant PDOCL scaffolds showing a fast degradation rate, indicating the formation of a small amount of acidic by-products compared to the PLGA scaffolds. From the results, it was expected that the PDOCLs can be a new flexible scaffolding material with different degradation rate for various tissue-engineering applications.
authors.affiliation: a Department of Advanced Materials, Hannam University, 461-6 Jeonmin Dong, Yuseong Gu, Daejeon 305-811, South Korea.
authors.forename: Se Heang
authors.initials: SH
authors.lastname: Oh
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Park
authors.forename: Hea Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Koh
authors.forename: June-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D020341:Absorbable Implants; D055359:Antistatic Agents; D002152:Calorimetry, Differential Scanning; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D016687:Polydioxanone / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D066244:Proton Magnetic Resonance Spectroscopy; D013696:Temperature; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*; D014783:Viscosity
chemical_list: D055359:Antistatic Agents; D011091:Polyesters; C016240:polycaprolactone; D016687:Polydioxanone