[The use of 2-octyl cyanoacrylate in colonic anastomosis: experimental study in wistar rats].
OBJECTIVE
To compare the effect of 2-octyl cyanoacrylate tissue adhesive with polypropylene suture on the healing of colonic anastomosis in Wistar rats.


METHODS
Thirty two animals, divided in four groups of eight, were established concerning suture with Polypropylene or Cyanoacrylate application, and the day chose for euthanasia: third or seventh day following operation. In the control group, the anastomosis was done in a single layer with 5.0 polypropylene suture. In the adhesive group, the anastomosis was performed by using 2-octyl cyanoacrylate. Operative time, integrity and gross anastomotic healing, bursting pressure, intestinal obstruction, adhesions formation, histological healing and inflammatory process were recorded.


RESULTS
Adhesion formation was more extensive in the cyanoacrylate group on the seventh postoperative day comparing with suture group (p=0.007). Mechanical strength of the anastomosis assessed on the seventh postoperative day was lower in 2-octyl cyanoacrylate group (p=0.002). Partial intestinal obstruction rate were more frequent in anastomosis using 2-octyl cyanoacrylate compared to those with polypropylene suture on the seventh postoperative day (p=0.029). Operative time were longer in groups with adhesive (p=0.004). The wound healing process, and inflammatory process did not differ statistically between groups (p>0.05).


CONCLUSIONS
The application of 2-octyl cyanoacrylate, under experimental conditions seems to be detrimental at the seventh day of the healing, causing intense adhesion formation, colonic obstruction; and impairment healing with less mechanical strength resistance.
Soares Júnior
Cleber
C
Hospital e Maternidade Therezinha de Jesus, MG, BR. cleberdoc@ig.com.br
Souza
Cláudio de
Cd
D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery*; D003487:Cyanoacrylates / Q000009:adverse effects; D008297:Male; D008422:Materials Testing; D011126:Polypropylenes / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013537:Sutures / Q000009:adverse effects; D014014:Tissue Adhesives / Q000009:adverse effects
D003487:Cyanoacrylates; D011126:Polypropylenes; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate