Channelopathic pain: a growing but still small list of model disorders.
In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarching concepts and questions.
Waxman
Stephen G
SG
Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA. stephen.waxman@yale.edu