title: Zeolite/polymer composite hollow microspheres containing antibiotics and the in vitro drug release.
abstract: Hemorrhage remains a leading cause of early death after trauma, especially those with infectious complications in combat wounds. The aim of this study was to develop antibiotics-loaded zeolite (Zel)/polymer composites for hemostatic materials. The composite materials were fabricated from zeolite and various biodegradable polymers, including chitosan (CS), gelatin (Gel) and alginate (Alg), using the inversed emulsion method. The morphology of the composites was observed by SEM, and the results showed that the prepared Zel/polymer composites can form hollow microspheres under appropriate conditions. The microspheres contained three sizes of pores, nano-pore of zeolite, micrometer-sized pores between zeolite particles, and void cores having a size of tens of micrometers. It was these pores that made the composites have unexpected water-absorbing capacity. When antibiotics were loaded into the composite microspheres, they exhibited a prolonged drug-releasing period. Thus, we can make full use of the characteristics of chitosan, zeolite and antibiotics to create potential dual-functional hemostatic materials.
authors.affiliation: School of Science, Tianjin University, Tianjin 300072, PR China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: He
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Fubao
authors.initials: F
authors.lastname: Xing
authors.forename: Haixia
authors.initials: H
authors.lastname: Qiu
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Danyang
authors.initials: D
authors.lastname: Ma
authors.forename: Tong
authors.initials: T
authors.lastname: Lin
authors.forename: Jianping
authors.initials: J
authors.lastname: Gao
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism*; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D048271:Chitosan / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry / Q000378:metabolism; D020723:Glucuronic Acid / Q000737:chemistry / Q000378:metabolism; D006490:Hemostatics / Q000737:chemistry / Q000378:metabolism; D006603:Hexuronic Acids / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011108:Polymers; D017641:Zeolites / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D006490:Hemostatics; D006603:Hexuronic Acids; D011108:Polymers; D017641:Zeolites; D020723:Glucuronic Acid; D005780:Gelatin; D048271:Chitosan