Helium:oxygen versus air:oxygen noninvasive positive-pressure ventilation in patients exposed to sulfur mustard.
Exposure to sulfur mustard (SM) causes a variety of respiratory symptoms, such as chronic bronchitis and constrictive bronchiolitis. This study assessed the effectiveness of noninvasive positive-pressure ventilation, adjunct with 79:21 helium:oxygen instead of 79:21 air:oxygen, in 24 patients with a previous exposure to SM presenting with acute respiratory failure. Both air:oxygen and helium:oxygen significantly decreased systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse rate, respiratory rate, dyspnea, and increased oxygen saturation (P values: .007, .029, .002, <.001, <.001, <.001, and .002 for air:oxygen, respectively, and <.001, .020, .001, <.001, <.001, <.001, and .002, for helium:oxygen, respectively). Moreover, helium:oxygen more potently improved systolic pressure, mean arterial pressure, pulse rate, respiratory rate, and dyspnea (P values: .012, .048, <.001, <.001, and .012, respectively). The results of our study support the benefit of using helium:oxygen adjunct with noninvasive positive-pressure ventilation in patients exposed to SM with acute respiratory decompensation.
Ghanei
Mostafa
M
Research Center of Chemical Injuries, Baqiyatallah Medical Science University, Tehran, Iran. mghaneister@gmail.com
Rajaeinejad
Mohsen
M
Motiei-Langroudi
Rouzbeh
R
Alaeddini
Farshid
F
Aslani
Jafar
J
D000328:Adult; D000388:Air; D000403:Airway Resistance / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001988:Bronchiolitis / Q000139:chemically induced* / Q000451:nursing*; D001991:Bronchitis / Q000139:chemically induced* / Q000451:nursing*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002908:Chronic Disease; D045422:Continuous Positive Airway Pressure / Q000379:methods* / Q000451:nursing*; D004417:Dyspnea / Q000139:chemically induced / Q000451:nursing; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006371:Helium; D006801:Humans; D007492:Iran; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D009151:Mustard Gas / Q000633:toxicity*; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy / Q000379:methods* / Q000451:nursing*; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000451:nursing*; D056152:Respiratory Rate
D002619:Chemical Warfare Agents; D006371:Helium; C038949:heliox; D010100:Oxygen; D009151:Mustard Gas