Cause of death among people with retroviral infection in rural Guinea-Bissau.
HIV-2 and HTLV-1 infection are both associated with increased mortality, but the causes of death are not well known. Relatives of 84 deceased persons from a rural part of Guinea-Bissau were interviewed using a standardised verbal autopsy questionnaire in the context of a large longitudinal community cohort study. The results were reviewed by two doctors to conclude cause of death. A cause of death was agreed upon for 49/84 subjects. Nineteen of these 49 were infected with HIV-2 alone and 7 with both HIV-2 and HTLV-1. Among these, the main causes of death were pulmonary tuberculosis (n = 5), AIDS (n = 5), cerebrovascular accident (n = 5), sepsis (n = 3) and hepatocellular carcinoma (n = 2). Death associated with traditional HIV-related causes were implicated in 13/26 (50%) of those with HIV-2.
Cooper
Maxwell
M
Glagow University, General Practice and Primary Care, Scotland, UK. mjfcooper@clinmed.gla.ac.uk
van der Loeff
Maarten Schim
MS
McConkey
Samuel
S
Cooper
Sarah
S
Vincent
Tim
T
Whittle
Hilton
H
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006169:Guinea-Bissau / Q000453:epidemiology; D015658:HIV Infections / Q000401:mortality*; D015497:HIV-1; D015498:HIV-2; D015490:HTLV-I Infections / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population