title: Protective effects of methanolic extract of Hedyotis puberula (G. Don) R. Br. ex Arn. against experimentally induced gastric ulcers in rat.
abstract: OBJECTIVE
  This study was aimed to evaluate the antiulcer activity of the whole plants of Hedyotis puberula (G. Don) R. Br. ex Arn.
  
  
  METHODS
  Gastroprotective potential of the Hedyotis puberula methanol extract (200 and 400mg/kg body weight) was studied on indomethacin (IND), ethanol and pyloric ligation (PL)-induced gastric ulcer models in rats.
  
  
  RESULTS
  The treatment with Hedyotis puberula extract at 400mg/kg p.o. protected the rats against the ulceration which was comparable to the reference drug omeprazole. Pretreatment with extract protected rats from gastric lesion development by way of increased pH and decreased volume, acidity and pepsin content of gastric secretion. Furthermore, total carbohydrate: protein ratio of the gastric juice were noticeably increased in pretreated rats.
  
  
  CONCLUSIONS
  Results of our study showed that Hedyotis puberula possess significant gastroprotective activity and validate the folklore claim.
authors.affiliation: Department of Botany, School of Life Sciences, Bharathiar University, Coimbatore, 641046 Tamil Nadu, India.
authors.forename: Jince Mary
authors.initials: JM
authors.lastname: Joseph
authors.forename: Kandhasamy
authors.initials: K
authors.lastname: Sowndhararajan
authors.forename: Sellamuthu
authors.initials: S
authors.lastname: Manian
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D032064:Hedyotis; D008297:Male; D000432:Methanol; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018514:Plant Structures; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D020011:Protective Agents; D000432:Methanol