title: Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta.
abstract: Three new sulfated sterol dimers, fibrosterol sulfates A-C (1-3), have been isolated from the sponge Lissodendoryx (Acanthodoryx) fibrosa, collected in the Philippines. The structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1 and 2 inhibited PKCzeta with IC(50) values of 16.4 and 5.6 microM, respectively.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Whitson
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
authors.forename: Priya S
authors.initials: PS
authors.lastname: Chockalingam
authors.forename: Gisela P
authors.initials: GP
authors.lastname: Concepcion
authors.forename: Xidong
authors.initials: X
authors.lastname: Feng
authors.forename: Guixian
authors.initials: G
authors.lastname: Jin
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Harper
authors.forename: Gina C
authors.initials: GC
authors.lastname: Mangalindan
authors.forename: Leonard A
authors.initials: LA
authors.lastname: McDonald
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000818:Animals; D045424:Complex Mixtures / Q000737:chemistry; D019281:Dimerization; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D011161:Porifera / Q000737:chemistry*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry*; D000099221:Protein Kinase C zeta
chemical_list: D045424:Complex Mixtures; D000432:Methanol; D011493:Protein Kinase C; D047428:Protein Kinase Inhibitors; D013261:Sterols; D013431:Sulfates; D000099221:Protein Kinase C zeta