Quality and quantity control at the endoplasmic reticulum.
The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins that together make up about one third of the cellular proteome. Cells carefully control the synthetic output of this organelle to regulate both quality and quantity of proteins that emerge. Here, we synthesize current concepts underlying the pathways that mediate protein degradation from the ER and their deployment under physiologic and pathologic conditions.
Hegde
Ramanujan S
RS
Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. hegder@mail.nih.gov
Ploegh
Hidde L
HL
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D053858:Metabolic Networks and Pathways; D011499:Protein Processing, Post-Translational; D013312:Stress, Physiological