Phyllodes tumor of the breast; a case series.
BACKGROUND
Phyllodes tumor (PT) is a rare neoplasm comprising less than 1% of all breast tumors. Its clinical spectrum ranges from a benign and locally recurrent form of behavior to malignant and metastatic forms. The aim of the study was to evaluate the clinical characteristics, treatment regimens, survival and late complications in patients with PT.


METHODS
We retrospectively reviewed the medical records of 10 women who were treated for PT in our center between 1998 and 2002. All cases were histologically examined by an experienced breast pathologist, and tumors were classified as benign, borderline malignant or malignant according to standard histological criteria.


RESULTS
The median age at diagnosis was 45.5 years (range: 21-69 years). Seven (70%) of 10 tumors were benign and 3 (30%) were malignant. The median tumor size was 29 mm (range: 12-80 mm). The least safe margin was 1 cm. Three of 10 patients had malignant PT and underwent simple mastectomy. Local recurrence was determined in no patients. Only one patient had lung metastasis. Median follow-up period was 62 months (range, 12-96 months). The patient with lung metastasis was treated with doxorubicine but died one year after the operation.


CONCLUSIONS
PT is a rare neoplasm of the breast. It resembles fibroadenoma. Local excision with appropriate surgical margins seems adequate in all patients (Tab. 1, Fig. 3, Ref. 15). Full Text (Free, PDF) www.bmj.sk.
Akin
Murat
M
Gazi University Medical School, Department of General Surgery, Ankara, Turkey. makin@gazi.edu.tr
Irkorucu
Oktay
O
Koksal
Hande
H
Gonul
Ipek Isik
II
Gultekin
Serap
S
Kurukahvecioglu
Osman
O
Anadol
Ahmet Ziya
AZ
Tekin
Ercument
E
D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000473:pathology / Q000601:surgery; D055815:Young Adult