[Intraduodenal infusion of levodopa].
In the advanced stages of Parkinson's disease (PD), the conventional orally-administered pharmacological treatment can prove to be insufficient to control the motor complications associated with the disease. One of the causes involved in the genesis of the motor fluctuations that are observed in PD is the variable absorption of the medication due to an irregular or erratic emptying of the gastric content. Today, a method of therapy is now available that allows levodopa to be administered directly into the duodenum at a continuous rate by a perfusor. The medication is applied through a duodenal catheter implanted by means of a percutaneous endoscopic gastrostomy. This new form of administration has been marketed under the name of Duodopa, which is a pharmaceutical form of levodopa in a micronised suspension in a thickening gel consisting of sodium carmelose. It is presented in combination with levodopa (20 mg/mL) and a dopa decarboxylase inhibitor, carbidopa (5 mg/mL). Duodopa has proved to be effective in reducing the percentage of off time and in diminishing the periods with disabling dyskinesias. This therapy has also proved to be useful for relieving certain non-motor aspects associated with PD and presents fewer limitations regarding indication for advanced PD patients than those that usually exist for the case of deep brain stimulation. Although the therapy has proved to be effective, it is not free of complications arising from malfunctioning of the infusion system or in relation to the percutaneous endoscopic gastrostomy.
Valldeoriola
Francesc
F
Unidad de Trastornos del Movimiento, Servicio de Neurología, Institut de Neurociències, Hospital Clínic, Universitat de Barcelona, Barcelona, España. fvallde@clinic.ub.es
Cámara
Ana
A
D002230:Carbidopa / Q000627:therapeutic use; D046690:Deep Brain Stimulation; D015259:Dopamine Agents / Q000494:pharmacology / Q000627:therapeutic use; D004333:Drug Administration Routes; D004386:Duodenum / Q000187:drug effects*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*; D016896:Treatment Outcome
D015259:Dopamine Agents; D007980:Levodopa; D002230:Carbidopa