title: Assessment of acute toxicity and reproductive capability of a herbal combination.
abstract: The drug under investigation is a herbal combination of Withania somnifera, Tribulus terrestris, Mucuna Pruriens and Argyreia speciosa which has been used for several years of its bio-stimulating, revitalizing and fertility enhancing effects. Present preclinical study is specifically designed to access the safety and efficacy of the product. The result of acute oral toxicity reveals that product is safe up to the dose of 5000 mg/kg. The effects of study related to reproductive capability of drug on both sex reveals increase in reproduction rate up to two generations i.e. F(0) and F(1).
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan.
authors.forename: Azra
authors.initials: A
authors.lastname: Riaz
authors.forename: Rafeeq Alam
authors.initials: RA
authors.lastname: Khan
authors.forename: Shadab
authors.initials: S
authors.lastname: Ahmed
authors.forename: Syeda
authors.initials: S
authors.lastname: Afroz
mesh_terms: D000818:Animals; D005260:Female; D005298:Fertility / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000633:toxicity*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*