title: Reference values of tissue Doppler imaging and pulsed Doppler echocardiography for analysis of left ventricular diastolic function in healthy adults.
abstract: To determine reference values for tissue Doppler imaging (TDI) and pulsed Doppler echocardiography for left ventricular diastolic function analysis in a healthy Brazilian adult population. Observations were based on a randomly selected healthy population from the city of Vitória, Espírito Santo, Brazil. Healthy volunteers (n = 275, 61.7% women) without prior histories of cardiovascular disease underwent transthoracic echocardiography. We analyzed 175 individuals by TDI and evaluated mitral annulus E'- and A'-waves from the septum (S) and lateral wall (L) to calculate E'/A' ratios. Using pulsed Doppler echocardiography, we further analyzed the mitral E- and A-waves, E/A ratios, isovolumetric relaxation times (IRTs), and deceleration times (DTs) of 275 individuals. Pulsed Doppler mitral inflow mean values for men were as follows: E-wave: 71 ± 16 cm/sec, A-wave: 68 ± 15 cm/sec, IRT: 74.8 ± 9.2 ms, DT: 206 ± 32.3 ms, E/A ratio: 1.1 ± 0.3. Pulsed Doppler mitral inflow mean values for women were as follows: E-wave: 76 ± 17, A-wave: 69 ± 14 cm/sec, IRT: 71.2 ± 10.5 ms, DT: 197 ± 33.3 ms, E/A ratio: 1.1 ± 0.3. IRT and DT values were higher in men than in women (P = 0.04 and P = 0.007, respectively). TDI values in men were as follows: E'S: 11± 3 cm/sec, A'S: 13 ± 2 cm/sec, E'S/A'S: 0.89 ± 0.2, E'L: 14 ± 3 cm/sec, A'L: 14 ± 2 cm/sec, E'L/A'L: 1.1± 0.4. E-wave/ E'S ratio: 6.9 ± 2.2; E-wave / E'L ratio: 4.9 ± 1.7. In this study, we determined pulsed Doppler and TDI derived parameters for left ventricular diastolic function in a large sample of healthy Brazilian adults.
authors.affiliation: Heart Institute (InCor), São Paulo University Medical School, São Paulo, Brazil. langel@terra.com.br
authors.forename: Lilian C
authors.initials: LC
authors.lastname: Angelo
authors.forename: Marcelo L C
authors.initials: ML
authors.lastname: Vieira
authors.forename: Sergio L
authors.initials: SL
authors.lastname: Rodrigues
authors.forename: Renato
authors.initials: R
authors.lastname: Morelato
authors.forename: Alexandre C
authors.initials: AC
authors.lastname: Pereira
authors.forename: José G
authors.initials: JG
authors.lastname: Mill
authors.forename: José E
authors.initials: JE
authors.lastname: Krieger
mesh_terms: D001938:Brazil; D018619:Echocardiography, Doppler, Pulsed / Q000592:standards*; D054459:Elasticity Imaging Techniques / Q000592:standards*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume