A synthesis of the C1-C15 domain of the halichondrins.
A concise route to the C1-C15 domain of the halichondrins is described. The key reaction is the conversion of a furfuryl alcohol to a pyranone. The stereocenter of this pyranone serves as the starting point for the other 8 stereocenters.
Jackson
Katrina L
KL
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA.
Henderson
James A
JA
Morris
Jonathan C
JC
Motoyoshi
Hajime
H
Phillips
Andrew J
AJ