Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease.
OBJECTIVE
Impulsive-compulsive behaviours (ICBs) in Parkinson's disease (PD) have been anecdotally linked with impaired sleep. The authors investigate measures of sleep in PD patients with and without ICBs, and in healthy controls.


METHODS
The authors compare Parkinsonian features, measures of depression, anxiety and mania, and sleep disturbance in 30 PD patients with ICBs (PD+ICB), 62 PD patients without ICBs (PD-ICB) and 48 healthy controls.


RESULTS
PD+ICB patients had a younger age of PD onset, took more dopamine replacement therapy (DRT) and had worse sleep, and elevated anxiety, depression and mania scores. Using multiple linear regression analyses, the total anxiety and depression scores, and presence of ICBs were the only variables associated with poorer sleep in PD.


CONCLUSIONS
PD+ICB patients may show enhanced psychomotor effects of DRT that may in turn contribute to poor sleep quality. Sleep disturbance should be specifically queried in PD+ICB patients.
O'Sullivan
Sean S
SS
Reta Lila Weston Institute of Neurological Studies, University College London, London, UK.
Loane
Clare M
CM
Lawrence
Andrew D
AD
Evans
Andrew H
AH
Piccini
Paola
P
Lees
Andrew J
AJ
D000368:Aged; D001007:Anxiety / Q000150:complications; D003192:Compulsive Behavior / Q000139:chemically induced* / Q000150:complications; D003863:Depression / Q000150:complications; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D012893:Sleep Wake Disorders / Q000139:chemically induced* / Q000150:complications
D018491:Dopamine Agonists