[The influence of intrastriatal and systemic microinjections of nicotine on motor behavior and its motor and postural components in dogs].
In chronic experiments in dogs on a model of instrumental avoidance reflex we have found that intrastriatal and/or systemic injection of nicotine causes a significant prolonged increase of motor excitability. By decrease of latent period of instrumental reflex, an increase of amplitude of reflex was shown and, in some cases, by increase of conditional flexion maintenance time. An interesting feature of instrumental reflex in our investigations was both strengthening of cholinergic influence and strengthening of dopaminergic influence. The former is shown by sharp strengthening of tonic component of answer, the latter--by increase of answer amplitude and decrease of its latency, increase of general excitability.
Shapovalova
K B
KB
Tikhomirova
P L
PL
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004285:Dogs; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D017072:Neostriatum / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011187:Posture
D018722:Nicotinic Agonists; D009538:Nicotine