title: [A case of drug-induced pneumonia caused by clopidogrel].
abstract: A 65-year-old man, who had been given a diagnosis of angina pectoris, developed pneumonia 6 months after the initiation of clopidogrel to inhibit platelet aggregation. Chest radiography showed bilateral invasive shadows, and he was admitted to our hospital. He was asymptomatic, but his C-reactive protein and erythrocyte sedimentation rate were elevated. A lymphocyte stimulation test (DLST) with clopidogrel was positive, and bronchoalveolar lavage fluid showed an increase in lymphocytes and a decrease in the CD4+/CD8+ ratio. We noticed no radiologic improvement a week after prednisolone therapy (30 mg/day) with clopidogrel as stated. However, the airspace consolidation had slightly reduced after clopidogrel was halted. We found a few cases of ticlopidine-induced pneumonia, in the literature, but we found no cases of pulmonary adverse events caused by clopidogrel. To the best of our knowledge this is the first case of clopidogrel-induced pneumonia.
authors.affiliation: Department of Internal Medicine, Ikuwakai Memorial Hospital.
authors.forename: Gakuya
authors.initials: G
authors.lastname: Tamagaki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Matsushita
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suzumura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamada
authors.forename: Kazuto
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D000077144:Clopidogrel; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine