Cembranolides from the stem bark of the southern African medicinal plant, Croton gratissimus (Euphorbiaceae).
The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines.
Mulholland
Dulcie A
DA
Division of Chemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK. D.mulholland@surrey.ac.uk
Langat
Moses K
MK
Crouch
Neil R
NR
Coley
Helen M
HM
Mutambi
Emily M
EM
Nuzillard
Jean-Marc
JM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013019:South Africa; D013237:Stereoisomerism
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes