Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C-H bond activation.
An efficient and facile deuterium labeling of sugars has been achieved in a completely regio-, chemo- and stereoselective manner using the Ru/C-H(2)-D(2)O combination via C-H bond activation assisted by the coordination of Ru to the oxygen atom of the sugar-hydroxyl groups.
Fujiwara
Yuta
Y
Laboratory of Organic Chemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Iwata
Hiroki
H
Sawama
Yoshinari
Y
Monguchi
Yasunari
Y
Sajiki
Hironao
H
D002241:Carbohydrates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry*; D041961:Deuterium Exchange Measurement; D006859:Hydrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D002241:Carbohydrates; D002244:Carbon; D012428:Ruthenium; D006859:Hydrogen; D003903:Deuterium; D010100:Oxygen