Up-regulation of MHC class I and class II in the skeletal muscles of myasthenia gravis.
The up-regulation of MHC in muscles is thought to be associated with inflammatory myopathies. The expression of MHC class I and class II was examined in muscles of myasthenia gravis (MG). MG muscle specimens from all 5 patients with thymoma and 2 of 5 without thymoma showed MHC class I up-regulation and 3 of 5 with thymoma showed MHC class II. The up-regulation of MHC in MG muscles is thus considered to be a common phenomenon. MG muscles expressed not only MHC class I but also class II, and these muscles could thus act as immunoregulating cells in MG.
Iwasa
Kazuo
K
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. neuiwasa@med.kanazawa-u.ac.jp
Kato-Motozaki
Yuko
Y
Furukawa
Yutaka
Y
Maruta
Takahiro
T
Ishida
Chiho
C
Yoshikawa
Hiroaki
H
Yamada
Masahito
M
D000293:Adolescent; D000328:Adult; D005260:Female; D015234:HLA-A Antigens / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000150:complications / Q000473:pathology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism; D013945:Thymoma / Q000150:complications / Q000473:pathology; D015854:Up-Regulation / Q000502:physiology*; D055815:Young Adult
D015234:HLA-A Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D019837:Ryanodine Receptor Calcium Release Channel; D017493:Leukocyte Common Antigens