Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones.
New amino acid-based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et(2) Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)-1e under mild conditions.
Gou
Shaohua
S
Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
Judeh
Zaher M A
ZM
D002384:Catalysis; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D009942:Organometallic Compounds / Q000737:chemistry*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D013237:Stereoisomerism
D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; D010649:Phenylalanine; D003300:Copper; C454811:diethylzinc