Expression of genes that encode the annexin-1 and galectin-1 proteins in nasal polyposis and their modulation by glucocorticoid.
Rhinosinusal polyps physiopathology is not fully understand, despite numerous hypotheses regarding its inflammatory process.


OBJECTIVE
A prospective study regarding the gene expression of proteins: anexin-1 and galectin-1, which has an anti-inflammatory action and is modulated by steroids.


METHODS
Eleven patients with rhinosinusal polyps suffered a biopsy of their polyps at two moments: in the absence of systemic steroids and during its use. In the two samples we assessed the expression of these genes and compared it to the normal nasal mucosa in the middle meatus.


RESULTS
We noticed that the mean expression of the genes which code anexin-1 and galectin-1 was predominantly increased, regardless of the use of steroids in relation to the control nasal mucosa. Notwithstanding, in polyps without the use of steroids, the mean gene expression of anexin-1 was significantly higher than in the polyps which were under the use of steroids. Regarding galectin-1, there was no significant difference between the expression mean values before and after the use of systemic steroids.


CONCLUSIONS
The genes present an expression increase in the polyp mucosa, regardless of the use of steroids; nonetheless, the relationship of these two genes of anti-inflammatory proteins with steroids did not happen the same way.
Fernandes
Atílio Maximino
AM
Otorhinolaryngology and head & neck surgery department of Famerp, São José do Rio Preto, SP.
Babeto
Erica
E
Rahal
Paula
P
Provazzi
Paola Jocelan Scarin
PJ
Hidalgo
Claudia Augusta
CA
Anselmo-Lima
Wilma T
WT
D000328:Adult; D000368:Aged; D017305:Annexin A1 / Q000235:genetics* / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001623:Betamethasone / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D037483:Galectin 1 / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism; D011446:Prospective Studies
D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D037483:Galectin 1; D005938:Glucocorticoids; D001623:Betamethasone