title: New insights into protein O-mannosylation in actinomycetes.
abstract: Glycosylation is a common post-translational modification of surface exposed proteins and lipids present in all kingdoms of life. Information derived from bacterial genome sequencing, together with proteomic and genomic analysis has allowed the identification of the enzymatic glycosylation machinery. Among prokaryotes, O-mannosylation of proteins has been found in the actinomycetes and resembles protein O-mannosylation in fungi and higher eukaryotes. In this review we summarize the main features of the biosynthetic pathway of O-mannosylation in prokaryotes with special emphasis on the actinomycetes, as well as the biological role of the glycosylated target proteins.
authors.affiliation: Departamento de Inmunologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF, México.
authors.forename: Clara
authors.initials: C
authors.lastname: Espitia
authors.forename: Luis
authors.initials: L
authors.lastname: Servín-González
authors.forename: Raúl
authors.initials: R
authors.lastname: Mancilla
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D008358:Mannose / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D008358:Mannose