Alternative influenza vaccines made by insect cells.
The recent outbreak of swine-origin H1N1 influenza virus demonstrated the potential threat of new emerging human pathogenic influenza strains. Additionally, seasonal influenza virus strains cause substantial morbidity and mortality every year. Egg-derived influenza vaccines have served well to combat influenza infections since the 1940s. Still, faster and safer high-yielding production methods have to be established to meet the current needs for influenza vaccines. Insect cell-derived influenza vaccines are a new alternative to egg-derived vaccines. Three different approaches to insect cell-derived influenza vaccines have been established that could contribute to future influenza vaccine supply and development.
Krammer
Florian
F
Vienna Institute of BioTechnology (VIBT), Department of Biotechnology, University of Natural Resources and Applied Life Sciences, 1190 Vienna, Austria.
Grabherr
Reingard
R
D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D007252:Influenza Vaccines / Q000096:biosynthesis* / Q000276:immunology; D007313:Insecta / Q000166:cytology* / Q000821:virology; D014161:Transduction, Genetic; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D014771:Virion / Q000235:genetics / Q000276:immunology
D007252:Influenza Vaccines; D014764:Viral Proteins