title: Computational analysis of human adenovirus serotype 18.
abstract: The genome of the sole remaining unsequenced member of species A, human adenovirus type 18 (HAdV-A18), has been sequenced and analyzed. Members of species A are implicated as gastrointestinal pathogens and were shown to be tumorigenic in rodents. These whole genome and in silico proteome data are important as references for reexamining and integrating earlier work and observations based on lower resolution techniques, such as restriction enzyme digestion patterns, particularly for hypotheses based on pre-genomics data. Additionally, the genome of HAdV-A18 will also serve as reference for current studies examining the molecular evolution and origins of human and simian adenoviruses, particularly genome recombination studies. Applications of this virus as a potential vector for gene delivery protocols may be practical as data accumulate on this and other adenovirus genomes.
authors.affiliation: Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd., MSN 5B3, Manassas, VA 20110, USA. mwalsh5@gmu.edu
authors.forename: Michael P
authors.initials: MP
authors.lastname: Walsh
authors.forename: Jason
authors.initials: J
authors.lastname: Seto
authors.forename: Damaris
authors.initials: D
authors.lastname: Tirado
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
authors.forename: David
authors.initials: D
authors.lastname: Schnurr
authors.forename: Donald
authors.initials: D
authors.lastname: Seto
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
mesh_terms: D000260:Adenoviruses, Human / Q000145:classification* / Q000235:genetics*; D001483:Base Sequence; D019295:Computational Biology; D004279:DNA, Viral / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization / Q000379:methods; D010802:Phylogeny; D020543:Proteome / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry; D012703:Serotyping
chemical_list: D004279:DNA, Viral; D020543:Proteome; D012367:RNA, Viral