title: Low-frequency rTMS with language therapy over a 3-month period for sensory-dominant aphasia: case series of two post-stroke Japanese patients.
abstract: OBJECTIVE
  To examine the safety and feasibility of therapeutic application of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with language therapy for post-stroke patients with sensory-dominant aphasia.
  
  
  METHODS
  Two post-stroke Japanese patients with sensory-dominant aphasia were studied. In both patients, 10 sessions of 20-minute low-frequency rTMS with 1 Hz to the Wernicke's area were provided throughout 6-day hospitalization, followed by weekly outpatient rTMS treatment for 3 months. The language therapy was also provided through the period of in- and out-patient treatment. Language function was evaluated using the Token test and the Standard Language Test of Aphasia (SLTA) at the start and end of the in-patient treatment and the end of the outpatient treatment.
  
  
  RESULTS
  The therapeutic protocol was well tolerated throughout the in- and out-patient treatments, without any adverse effects. The scores of the Token test and certain sub-categories of SLTA increased in both patients after the in-patient rTMS treatment. Persistent improvement of the score was noted over the 3-month post-discharge period.
  
  
  CONCLUSIONS
  The proposed protocol of long-term application of low-frequency rTMS to the Wernicke's area and language therapy is considered a safe and feasible therapeutic approach for post-stroke patients with sensory-dominant aphasia.
authors.affiliation: Department of Rehabilitation Medicine, University School of Medicine,Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Kakuda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abo
authors.forename: Go
authors.initials: G
authors.lastname: Uruma
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kaito
authors.forename: Motoi
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D001041:Aphasia, Wernicke / Q000503:physiopathology / Q000534:rehabilitation*; D044466:Asian People; D006801:Humans; D007808:Language Therapy; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000503:physiopathology; D000071939:Stroke Rehabilitation; D050781:Transcranial Magnetic Stimulation / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome