Total synthesis of (+)-dibromophakellin and (+)-dibromophakellstatin.
A new method for the preparation of quaternary chiral aminals has been developed that employs an enamide-type Overman rearrangement process. This methodology was applied to enantioselective total syntheses of (+)-dibromophakellin and (+)-dibromophakellstatin.
Imaoka
Takuya
T
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Akimoto
Takafumi
T
Iwamoto
Osamu
O
Nagasawa
Kazuo
K
D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D006909:Hydroxyproline / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D006576:Heterocyclic Compounds, 4 or More Rings; D007093:Imidazoles; C541047:dibromophakellin; C104805:dibromophakellstatin; D006909:Hydroxyproline