[Comparative efficacy of drug combinations for anesthesia of short-term traumatological operations in children].
A prospective randomized study was conducted to evaluate the efficiency of two intravenous anesthesia modes in children during traumatological operations. Anesthesia induction and maintenance were carried out via intravenous injection of ketamine (2 mg/kg/hr) and propofol (4 mg/kg/hr) in Group 1 children and via that of propofol (4 mg/kg/ hr) and fentanyl (3 microg/kg/hr) in Group 2. The mean duration of operations was 43.6 +/- 27.8 and 29.6 +/- 17.8 min in Groups 1 and 2, respectively. No complications were observed in Group 1; short-term apnea was seen in 2 (7.6%) children during initial anesthesia in Group 2. The children of this group were also found to have lower respiration rate. Both drug combinations were ascertained to provide a sufficient anesthesia depth in non-intubated, spontaneously breathing children, but the use of a combination of propofol + ketamine (Group 1) produced no negative impact on hemodynamics and external respiration parameters, which allowed this combination to be recommended for short-term surgical interventions.
Chichakhov
D A
DA
Gordeev
V I
VI
Aleksandrovich
Iu S
IuS
D000293:Adolescent; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D016343:Monitoring, Intraoperative; D019637:Orthopedic Procedures / Q000379:methods; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012119:Respiration / Q000187:drug effects; D013997:Time Factors; D015599:Trauma Severity Indices; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000601:surgery*
D018686:Anesthetics, Intravenous; D007649:Ketamine; D005283:Fentanyl; D015742:Propofol