Steroidal glycosides with anti-tumor activity from the roots of Cynanchum wallichii Wight.
Two new steroidal glycosides characterized with 2,6-dideoxypyranoses as component sugars have been isolated from roots of Cynanchum wallichii Wight. Their structure elucidation and cytotoxic activities against HL-60 and PC-3 cells are reported.
Chen
Gang
G
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Xu
Nan
N
Li
Zhi-Feng
ZF
Zhang
Qi-Hui
QH
Wu
Hong-Hua
HH
Pei
Yue-Hu
YH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031105:Cynanchum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010840:Phytosterols; C550643:qinyangshengenin-3-O-beta-D-oleandropyranosyl-(1-4)-beta-D-cymaropyranoside; C550642:qinyangshengenin-3-O-beta-D-oleandropyranosyl-(1-4)-beta-D-oleandropyranosyl-(1-4)-beta-D-cymaropyranoside