title: Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems.
abstract: The lemon grass, Cymbopogon citratus (DC) Stapf, is an important species of Poaceae family commonly used in the folk medicine in many countries. The aim of this study was to investigate the cytotoxic and genotoxic effects of aqueous extracts from C. citratus leaves on Lactuca sativa (lettuce) root tip meristem cells by cytogenetic studies that have never been done before for lemon grass extracts. For this, lettuce seeds were treated for 72h with different concentrations of lemon grass aqueous extracts (5; 10; 20 and 30 mg/mL). The percentage of germination, root development and cellular behavior were analyzed, and the results showed that the highest concentration of aqueous extracts reduced the mitotic index, the seed germination and the root development of lettuce. The extracts have also induced chromosome aberrations and cellular death in the roots cells of L. sativa.
authors.affiliation: Instituto de Ciências Biológicas, Departamento de Biologia, Universidade Federal de Juiz de Fora, MG, Brasil. saulo_marcal@yahoo.com.br <saulo_marcal@yahoo.com.br>
authors.forename: Saulo M
authors.initials: SM
authors.lastname: Sousa
authors.forename: Pâmela S
authors.initials: PS
authors.lastname: Silva
authors.forename: Lyderson F
authors.initials: LF
authors.lastname: Viccini
mesh_terms: D002869:Chromosome Aberrations / Q000139:chemically induced*; D031743:Cymbopogon / Q000737:chemistry*; D018525:Germination / Q000187:drug effects*; D018545:Lactuca / Q000166:cytology / Q000187:drug effects*; D018519:Meristem / Q000166:cytology / Q000187:drug effects*; D008940:Mitotic Index; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts