Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (> or =100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.
Stolzenberg-Solomon
Rachael Z
RZ
National Cancer Institute, Bethesda, Maryland 20852, USA.
Jacobs
Eric J
EJ
Arslan
Alan A
AA
Qi
Dai
D
Patel
Alpa V
AV
Helzlsouer
Kathy J
KJ
Weinstein
Stephanie J
SJ
McCullough
Marjorie L
ML
Purdue
Mark P
MP
Shu
Xiao-Ou
XO
Snyder
Kirk
K
Virtamo
Jarmo
J
Wilkins
Lynn R
LR
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
Zheng
Wei
W
Albanes
Demetrius
D
Cai
Qiuyin
Q
Harvey
Chinonye
C
Hayes
Richard
R
Clipp
Sandra
S
Horst
Ronald L
RL
Irish
Lonn
L
Koenig
Karen
K
Le Marchand
Loic
L
Kolonel
Laurence N
LN
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
D014807:Vitamin D