The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder.
Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.
Cohen-Woods
Sarah
S
Institute of Psychiatry, King's College London, MRC SGDP Centre, London, UK. sarah.cohen-woods@kcl.ac.uk
Craig
Ian
I
Gaysina
Darya
D
Gray
Joanna
J
Gunasinghe
Cerisse
C
Craddock
Nick
N
Elkin
Amanda
A
Jones
Lisa
L
Kennedy
James
J
King
Nicole
N
Korszun
Ania
A
Knight
Jo
J
Owen
Michael
M
Parikh
Sagar
S
Strauss
John
J
Sterne
Abram
A
Tozzi
Federica
F
Perry
Julia
J
Muglia
Pierandrea
P
Vincent
John
J
McGuffin
Peter
P
Farmer
Anne
A
D000483:Alleles; D001714:Bipolar Disorder / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D042965:Methylenetetrahydrofolate Reductase (NADPH2)