title: Synthesis and antileishmanial activity of lipophilic aromatic aminoalcohols.
abstract: In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro antiproliferative activity against promastigotes of three Leishmania species. The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi. The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50=5.2 and 0.7 microM, respectively).
authors.affiliation: Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil. robertacnr@bol.com.br
authors.forename: Roberta Novaes
authors.initials: RN
authors.lastname: Reis Corrales
authors.forename: Liliane Sena
authors.initials: LS
authors.lastname: Pinheiro
authors.forename: Elaine Soares
authors.initials: ES
authors.lastname: Coimbra
authors.forename: Adilson David
authors.initials: AD
authors.lastname: Da Silva
authors.forename: Mireille
authors.initials: M
authors.lastname: Le Hyaric
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism; D011073:Polyamines / Q000378:metabolism
chemical_list: D000605:Amino Alcohols; D000981:Antiprotozoal Agents; D011073:Polyamines