Neuropeptide action in insects and crustaceans.
Physiological processes are regulated by a diverse array of neuropeptides that coordinate organ systems. The neuropeptides, many of which act through G protein-coupled receptors, affect the levels of cyclic nucleotides (cAMP and cGMP) and Ca(2+) in target tissues. In this perspective, their roles in molting, osmoregulation, metabolite utilization, and cardiovascular function are highlighted. In decapod crustaceans, inhibitory neuropeptides (molt-inhibiting hormone and crustacean hyperglycemic hormone) suppress the molting gland through cAMP- and cGMP-mediated signaling. In insects, the complex movements during ecdysis are controlled by ecdysis-triggering hormone and a cascade of downstream neuropeptides. Adipokinetic/hypertrehalosemic/hyperprolinemic hormones mobilize energy stores in response to increased locomotory activity. Crustacean cardioacceleratory (cardioactive) peptide, proctolin, and FMRFamide-related peptides act on the heart, accessory pulsatile organs, and excurrent ostia to control hemolymph distribution to tissues. The osmoregulatory challenge of blood gorging in Rhodnius prolixus requires the coordinated release of serotonin and diuretic and antidiuretic hormones acting on the midgut and Malpighian tubules. These studies illustrate how multiple neuropeptides allow for flexibility in response to physiological challenges.
Mykles
Donald L
DL
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA. donald.mykles@colostate.edu
Adams
Michael E
ME
Gäde
Gerd
G
Lange
Angela B
AB
Marco
Heather G
HG
Orchard
Ian
I
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena; D003445:Crustacea / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006728:Hormones / Q000378:metabolism; D007313:Insecta / Q000502:physiology*; D018978:Molting / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology*; D009712:Nucleotides, Cyclic / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
D006728:Hormones; D009479:Neuropeptides; D009712:Nucleotides, Cyclic; D002118:Calcium