title: Status of copper and magnesium levels in diabetic nephropathy cases: a case-control study from South India.
abstract: Diabetic nephropathy is a complication of diabetes mellitus. This present study investigates the status of copper and magnesium in diabetic nephropathy cases to establish a possible relation. Forty patients of diabetic nephropathy participated in the study as cases. Forty age- and sex-matched healthy individuals served as controls. Blood samples were collected from both cases and controls for determination of FBS, PPBS, HbA1c, microalbumin, copper, and magnesium levels. The mean concentrations of FBS, PPBS, HbA1c, and microalbumin of cases were significantly higher than that of controls. The mean magnesium levels of cases (1.60 ± 0.32 meq/L) were significantly lower than controls 2.14 ± 0.16 meq/L (p < 0.05). But the mean copper levels of cases, 165.42 ± 5.71 μg/dl, shows no significant difference with controls, 166.6 ± 5.48 μg/dl, (p > 0.05).The findings in the present study suggest that hypomagnesemia may be linked with development of diabetic nephropathy.
authors.affiliation: Department of Biochemistry, NRI Medical College, General Hospital, Chinakakani, Guntur district, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Prabodh
authors.forename: D S R S
authors.initials: DS
authors.lastname: Prakash
authors.forename: G
authors.initials: G
authors.lastname: Sudhakar
authors.forename: N V S
authors.initials: NV
authors.lastname: Chowdary
authors.forename: V
authors.initials: V
authors.lastname: Desai
authors.forename: R
authors.initials: R
authors.lastname: Shekhar
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003300:Copper / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012709:Serum Albumin / Q000032:analysis; D014131:Trace Elements / Q000097:blood
chemical_list: D001786:Blood Glucose; D012709:Serum Albumin; D014131:Trace Elements; D003300:Copper; D008274:Magnesium