Hematopoietic stem cell transplantation in patients infected with HIV.
Hematopoietic stem cell transplantation (HSCT) replaces a diseased hematopoietic system with a functional, disease-free graft and is frequently used in the treatment of hematologic malignancies. The advent of highly active antiretroviral therapy made it possible to treat medical conditions in HIV-infected patients in the same way as in the general population. Several studies have reported the feasibility, safety, and efficacy of autologous HSCT as rescue or consolidation treatment for non-Hodgkin's and Hodgkin's lymphoma in HIV-infected patients. As a result of the improvements in supportive care and the introduction of attenuated transplant conditioning regimens, allogeneic HSCT has been used to treat life-threatening hematologic disorders, with promising results in HIV-infected patients. Moreover, this strategy has made it possible to treat both the hematologic disease and HIV infection.
Serrano
David
D
Servicio de Hematología, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007, Madrid, Spain. dserrano.hgugm@salud.madrid.org
Miralles
Pilar
P
Balsalobre
Pascual
P
Díez-Martin
José Luis
JL
Berenguer
Juan
J
D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006689:Hodgkin Disease / Q000150:complications / Q000628:therapy; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000628:therapy; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome