title: Bell's palsy: a manifestation of prediabetes?
abstract: BACKGROUND
  Idiopathic peripheral facial nerve palsy or Bell's palsy (BP) is the most common cause of facial nerve palsy.
  
  
  OBJECTIVE
  To evaluate the role of glucose metabolism abnormalities in BP.
  
  
  METHODS
  We identified 148 patients with unilateral BP and 128 control subjects. In all we evaluated glucose level at fasting and after a 2-h oral glucose tolerance test (2h-OGTT). In addition we determined insulin resistance (IR), by HOMA-index. Patients and controls were divided in to two groups, according to their Body Mass Index (BMI).
  
  
  RESULTS
  Following a 2h-OGTT, the prevalence of glucose metabolism abnormalities was significantly higher in patients with BP than in controls (P < 0.001). Impaired glucose tolerance (IGT) was found in 57 (38%) patients and in 23 (18%) controls, while a new-diagnosed DM (NDDM) was found in 29 (19%) patients and in 8 (6%) controls. The IR was significantly increased only in BP patients with BMI ≥ 24.9 (P = 0.005). BMI, waist circumference, blood pressure, tryglicerides, serum lipid, drugs use were not significantly different between patients and controls.
  
  
  CONCLUSIONS
  In this study we found that prediabetes is frequently associated with facial palsy. We propose to perform a 2h-OGTT in patients with peripheral facial palsy and normal fasting glycaemia. HOMA-index should be evaluated in obese facial palsy patients.
authors.affiliation: Department of Neuroscience, S. Giovanni di Dio Hospital, Crotone, Italy. nico_bosco@libero.it
authors.forename: D
authors.initials: D
authors.lastname: Bosco
authors.forename: M
authors.initials: M
authors.lastname: Plastino
authors.forename: F
authors.initials: F
authors.lastname: Bosco
authors.forename: A
authors.initials: A
authors.lastname: Consoli
authors.forename: A
authors.initials: A
authors.lastname: Labate
authors.forename: D
authors.initials: D
authors.lastname: Pirritano
authors.forename: D
authors.initials: D
authors.lastname: Consoli
authors.forename: A
authors.initials: A
authors.lastname: Fava
mesh_terms: D000328:Adult; D000368:Aged; D020330:Bell Palsy / Q000175:diagnosis / Q000209:etiology*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004576:Electromyography; D005215:Fasting / Q000502:physiology; D005260:Female; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000503:physiopathology*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008055:Lipids