title: Metformin compared with glyburide for the management of gestational diabetes.
abstract: OBJECTIVE
  To assess blood glucose control and neonatal outcomes when women with gestational diabetes mellitus (GDM) were treated with metformin or glyburide.
  
  
  METHODS
  When an appropriate diet was insufficient to control their blood glucose levels, women with GDM were randomized to a glyburide or a metformin treatment group. If the maximum dose was reached, the assessed drug was replaced by insulin. The primary outcome measures analyzed were maternal glucose levels during pregnancy, birth weight, and neonatal glucose levels.
  
  
  RESULTS
  The only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10.3 kg vs 7.6 kg; P=0.02). No differences were found in treatment failure, mean level of fasting or postprandial plasma glucose, rate of participants with glycated hemoglobin, birth weight, rate of large-for-gestational-age newborns, or newborns with hypoglycemia.
  
  
  CONCLUSIONS
  The treatment of GDM with metformin or glyburide was found to be equivalent for both women and newborns.
authors.affiliation: Department of Obstetrics, University of the Region of Joinville (UNIVILLE), Joinville, Brazil.
authors.forename: Jean Carl
authors.initials: JC
authors.lastname: Silva
authors.forename: Carina
authors.initials: C
authors.lastname: Pacheco
authors.forename: Juliana
authors.initials: J
authors.lastname: Bizato
authors.forename: Bárbara Vicente
authors.initials: BV
authors.lastname: de Souza
authors.forename: Thaís Engel
authors.initials: TE
authors.lastname: Ribeiro
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Bertini
mesh_terms: D001724:Birth Weight / Q000187:drug effects; D001786:Blood Glucose / Q000187:drug effects*; D016640:Diabetes, Gestational / Q000188:drug therapy*; D005215:Fasting; D005260:Female; D005905:Glyburide / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use*; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin