Predicting pregnancy in HIV-1-discordant couples.
This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.
Guthrie
Brandon L
BL
Department of Epidemiology, University of Washington, Seattle, WA 98104-2499, USA. brguth@u.washington.edu
Choi
Robert Y
RY
Bosire
Rose
R
Kiarie
James N
JN
Mackelprang
Romel D
RD
Gatuguta
Anne
A
John-Stewart
Grace C
GC
Farquhar
Carey
C
D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D015658:HIV Infections / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000453:epidemiology* / Q000523:psychology / Q000635:transmission; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D015994:Incidence; D007630:Kenya / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012098:Reproduction; D012307:Risk Factors; D018454:Spouses / Q000706:statistics & numerical data; D055815:Young Adult