Continuous positive airway pressure therapy improves arterial elasticity in patients with obstructive sleep apnea.
BACKGROUND
Reduced arterial elasticity is an important mediator of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). The aim of our study was to investigate whether continuous positive airway pressure (CPAP) therapy may improve arterial elasticity in subjects with OSA.


METHODS
In 44 subjects with OSA, we measured arterial elasticity by applanation tonometry before and after 6 months of treatment with CPAP. Nine OSA+ subjects withdrew from the study.


RESULTS
The 35 patients with OSA who completed the 6-month CPAP treatment showed a marked reduction in both the large artery (LAEI, P=0.001) and small artery (SAEI, P=0.009) elasticity indices, independent of potential confounders. In OSA+ subjects who withdrew from the study, SAEI and LAEI did not change significantly over time.


CONCLUSIONS
Six months of CPAP therapy improves arterial elasticity in subjects with OSA.
Eryilmaz
Salih
S
Department of Cardiology, Uludag University Medical School, Bursa, Turkey.
Aydinlar
Ali
A
Senturk
Tunay
T
Ursavas
Ahmet
A
Aydin Kaderli
Aysel
A
Ozdemir
Bülent
B
D001158:Arteries / Q000503:physiopathology*; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D004548:Elasticity / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome