title: A case of chronic hepatitis C developing insulin-dependent diabetes, thyroid autoimmunity and stiff-person syndrome as complications of interferon therapy.
abstract: We describe the case of a 66-year-old man with chronic hepatitis C who developed type 1 diabetes mellitus (T1DM) and thyroid autoimmunity during Interferon alpha (INFalpha) therapy and then stiff-person syndrome (SPS). This is the first reported case in which SPS has appeared as complication of IFNalpha therapy.
authors.affiliation: Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy. jekoide80@yahoo.it
authors.forename: G
authors.initials: G
authors.lastname: Scavone
authors.forename: F
authors.initials: F
authors.lastname: Zaccardi
authors.forename: A
authors.initials: A
authors.lastname: Manto
authors.forename: S
authors.initials: S
authors.lastname: Caputo
authors.forename: D
authors.initials: D
authors.lastname: Pitocco
authors.forename: G
authors.initials: G
authors.lastname: Ghirlanda
mesh_terms: D000368:Aged; D015551:Autoimmunity / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D016750:Stiff-Person Syndrome / Q000139:chemically induced*; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology
chemical_list: D016898:Interferon-alpha