title: Langerhans cell sarcoma of the cervical lymph node: a case report and literature review.
abstract: Langerhans cell sarcoma (LCS), a neoplastic proliferation of Langerhans cells with malignant cytologic features, is a very rare disease. We report the case of a 62-year-old male with LCS arising in a cervical lymph node. Histologic examination of a biopsy specimen of the lymph node demonstrated a proliferation of Langerhans cells with malignant cytologic features. Immunohistochemically, the tumor cells were positive for S-100 protein, CD1a, and Langerin (CD207). These histomorphological findings supported the diagnosis of LCS. The patient underwent radiotherapy. Neither local recurrence nor distant metastasis was observed at 45 months after radiotherapy. Characteristic immunohistochemical findings were helpful to identify LCS, and head and neck surgeons should be aware of this rare disease entity.
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Ibaraki Prefectural Central Hospital and Cancer Center, 6528 Koibuchi, Kasama, Ibaraki, Japan. nnmasa@hotmail.com
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakayama
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Takahashi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Hori
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okumura
authors.forename: Mistuaki
authors.initials: M
authors.lastname: Saito
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Keiji
authors.initials: K
authors.lastname: Tabuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
mesh_terms: D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D054752:Langerhans Cell Sarcoma / Q000175:diagnosis* / Q000532:radiotherapy; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009333:Neck; D049268:Positron-Emission Tomography; D012074:Remission Induction; D014057:Tomography, X-Ray Computed