Successful organ transplantation from donors poisoned with a carbamate insecticide.
Currently, liver transplantation is the only option for patients with end-stage liver disease. In Brazil, the mortality rate on the waiting list is about 25%. Multiple strategies to expand the donor pool are being pursed, however, grafts from poisoned donors are rarely used. This report documents successful liver, kidney and heart transplantations from four female donors who suffered brain death by hypoxia despite cardiopulmonary resuscitation following Aldicarb exposure ([2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)-oxime]). The success rate of 12 grafts from four donors poisoned by Aldicarb was 91% 6 months after transplantation. Poisoned patients are another pool of organ donors who at present are probably underused by transplantation services. More studies are necessary to confirm the safety for the recipients.
Garcia
J H
JH
Federal University of Ceara, Surgery, Fortaleza, CE, Brazil.
Coelho
G R
GR
Marques
G A
GA
Gadelha
J B
JB
Vasconcelos
J B
JB
Valença
J T
JT
Esmeraldo
R M
RM
Meija
J A
JA
Leite
C A
CA
Almeida
E R
ER
D000293:Adolescent; D000328:Adult; D002219:Carbamates / Q000506:poisoning*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000379:methods*; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D016030:Kidney Transplantation / Q000379:methods*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000379:methods*; D016896:Treatment Outcome; D014850:Waiting Lists; D055815:Young Adult
D002219:Carbamates; D007306:Insecticides