title: Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
abstract: 5-F substitution of an aminothiazole moiety within a series of thrombopoietin receptor agonists leads to potent agents with an improved hepatic safety profile in rodent toxicology studies.
authors.affiliation: Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Antipas
authors.forename: Laura C
authors.initials: LC
authors.lastname: Blumberg
authors.forename: William H
authors.initials: WH
authors.lastname: Brissette
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Brown
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Casavant
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Doty
authors.forename: James
authors.initials: J
authors.lastname: Driscoll
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Harris
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Jones
authors.forename: Sandra P
authors.initials: SP
authors.lastname: McCurdy
authors.forename: Eric
authors.initials: E
authors.lastname: McElroy
authors.forename: Mark
authors.initials: M
authors.lastname: Mitton-Fry
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Munchhof
authors.forename: David A
authors.initials: DA
authors.lastname: Reim
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Reiter
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Ripp
authors.forename: Andrei
authors.initials: A
authors.lastname: Shavnya
authors.forename: Marc I
authors.initials: MI
authors.lastname: Smeets
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Trevena
mesh_terms: D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D053628:Receptors, Thrombopoietin / Q000819:agonists*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D053628:Receptors, Thrombopoietin; D013844:Thiazoles