Promomycin, a polyether promoting antibiotic production in Streptomyces spp.
Widespread interspecific stimulation of antibiotic production occurs in strains of Streptomyces owing to the activity of diffusible substances, as previously determined in our investigations of the cross-feeding effect. In this study, we newly isolated a substance produced by a Streptomyces strain closely related to Streptomyces scabrisporus, based on the observation that this substance induced the production of an unknown antibiotic in another strain related to Streptomyces griseorubiginosus. This substance, named promomycin, is a polyether structurally related to lonomycin. Promomycin itself had an antibiotic activity, but it stimulated antibiotic production in multiple Streptomyces strains at sub-inhibitory concentrations. Evidence implies that this stimulation effect is widespread within this group of bacteria.
Amano
Sho-ichi
S
Life Science Research Center, College of Bioresource Sciences, Nihon University, Fujisawa, Kameino, Japan.
Morota
Tatsuya
T
Kano
Yu-ki
YK
Narita
Hiroyuki
H
Hashidzume
Tohko
T
Yamamoto
Setsuya
S
Mizutani
Kotaro
K
Sakuda
Shohei
S
Furihata
Kazuo
K
Takano-Shiratori
Hatsumi
H
Takano
Hideaki
H
Beppu
Teruhiko
T
Ueda
Kenji
K
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D000898:Antibiosis; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism*
D000900:Anti-Bacterial Agents