title: Vancomycin: the need to suit serum concentrations in hemodialysis patients.
abstract: The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the recommended value, indicating exposure to subtherapeutic doses and a higher risk for selecting resistant microorganisms.
authors.affiliation: Pharmacy School, Universidade de Sorocaba, Rua Silvério E. Oliveira 160, Jd. Saira Sorocaba, São Paulo, Brazil. mitoledo@yahoo.com
authors.forename: Lívia Luize
authors.initials: LL
authors.lastname: Marengo
authors.forename: Fernando de Sá
authors.initials: Fde S
authors.lastname: Del Fiol
authors.forename: Sara de Jesus
authors.initials: Sde J
authors.lastname: Oliveira
authors.forename: Celso
authors.initials: C
authors.lastname: Nakagawa
authors.forename: Eduardo Leite
authors.initials: EL
authors.lastname: Croco
authors.forename: Silvio
authors.initials: S
authors.lastname: Barberato-Filho
authors.forename: Marcela Pellegrini
authors.initials: MP
authors.lastname: Peçanha
authors.forename: Douglas Felix da
authors.initials: DF
authors.lastname: Silva
authors.forename: Maria Inês de
authors.initials: MI
authors.lastname: Toledo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood*; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin