[Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker].
OBJECTIVE
To explore the effect of heat shock protein 70(HSP70) gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker (CWP).


METHODS
100 workers whose sternites were assessed 0+ were chosen as the case group and 100 workers as the control. HSP70 genotypes were analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.


RESULTS
There were significantly differences in HSP70-1 b2/b2 genotype (chi2 = 8.26, P < 0.05) between the case group and the control ,the risks of CWP in the individuals with b2/b2 genotype were 2.36 times than those with b1/b1 genotype. The polymorphism of HSP70-2 and HSP70-hom had no statistics significance in the difference of the two groups.


CONCLUSIONS
The results suggested that the individual with HSP70-1 b2/b2 genotype may be a predisposing genotype to CWP and the individuals with the genotype could have weaker adaptability than the others.
Zhou
Fang
F
Department of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. zhoufang23@sina.com
Qin
Weidong
W
Wang
Yuzhen
Y
Li
Weihui
W
Liang
Shoupei
S
Yao
Wu
W
Wu
Yiming
Y
D000328:Adult; D055008:Anthracosis / Q000235:genetics*; D002681:China; D003031:Coal; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008906:Mining; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D003031:Coal; D018840:HSP70 Heat-Shock Proteins