Two-component approach toward a fully substituted N-fused pyrrole ring.
An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.
Chernyak
Dmitri
D
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
Skontos
Cathy
C
Gevorgyan
Vladimir
V
D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*
D006571:Heterocyclic Compounds; D011758:Pyrroles; D010165:Palladium; D009584:Nitrogen