title: Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination.
abstract: Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury.
authors.affiliation: Department of Histology and Embryology, Inonu University, Malatya, Turkey. drmukaddes@hotmail.com
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Eşrefoğlu
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ara
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001652:Bile Ducts / Q000601:surgery; D002109:Caffeic Acids / Q000494:pharmacology*; D002779:Cholestasis / Q000209:etiology / Q000473:pathology*; D022781:Hepatocytes / Q000187:drug effects* / Q000648:ultrastructure*; D008026:Ligation; D008099:Liver / Q000187:drug effects / Q000293:injuries / Q000648:ultrastructure; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008297:Male; D046529:Microscopy, Electron, Transmission; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol