The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation.
The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or transcriptional activation. Given its role as a regulator of cellular homeostasis it is not surprising that members of the UPS are frequently aberrantly expressed in a number of disease states including cancer. This review will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago, hCDC4) and mechanisms by which Fbw7 interacts with its substrates in the context of development and tumorigenesis will be discussed. In addition, antagonists of this pathway as well as current and future therapeutics for the UPS will be examined.
Crusio
K M
KM
Howard Hughes Medical Institute, Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
King
B
B
Reavie
L B
LB
Aifantis
I
I
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology*; D020598:Proto-Oncogene Proteins c-myb / Q000378:metabolism; D044843:SKP Cullin F-Box Protein Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism
D020598:Proto-Oncogene Proteins c-myb; D014452:Ubiquitins; D044843:SKP Cullin F-Box Protein Ligases