title: Genetic and functional study of the IPO5 gene in schizophrenia.
abstract: The present work reported on a weak association of the importin 5 (IPO5) gene with schizophrenia in combined family and case-control samples and also investigated a possible mechanism by which the IPO5 gene may contribute to the development of the disease in a Chinese population. Our results suggest that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia.
authors.affiliation: Research Center for Genomic Medicine and MH Radiobiology Research Unit, Jilin University, Changchun 130021, China.
authors.forename: Zhen-Qi
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Shun-Zi
authors.initials: SZ
authors.lastname: Jin
authors.forename: Gui-Zhi
authors.initials: GZ
authors.lastname: Ju
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Liu
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
mesh_terms: D000328:Adult; D002681:China; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D028961:beta Karyopherins / Q000235:genetics*
chemical_list: C107940:IPO5 protein, human; D028961:beta Karyopherins