Gene therapy takes a cue from HAART: combinatorial antiviral therapeutics reach the clinic.
For the first time, scientists have tested a combination of three RNA-based gene therapies, delivered via a lentiviral vector, to target HIV in patients. This study not only demonstrates the safety and long-term viability of this approach, but also highlights areas in which focused improvements in gene therapy strategies may provide the most impact in increasingly translating promise in the laboratory to efficacy in the clinic.
Shah
Priya S
PS
Department of Chemical Engineering, University of California, Berkeley, CA 94720-3220, USA.
Schaffer
David V
DV
D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D015658:HIV Infections / Q000188:drug therapy / Q000628:therapy; D006801:Humans