Lignan and neolignan glycosides from the roots of Glehnia littoralis.
A new lignan glycoside [glehlinoside G (1)] and three new neolignan glycosides [glehlinosides H (2), I (3) and J (4)] were isolated from the roots of Glehnia littoralis. Their structures were elucidated on the basis of spectroscopic data. The above glehlinosides (1-4), together with the other lignan and neolignan glycosides (5-12) from this plant, were evaluated for their prolyl oligopeptidase inhibitory activities, and a caffeoyled lignan glycoside (glehlinoside F, 8) exhibited a noticeable activity (IC(50) = 14.5 µM).
Xu
Yi
Y
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Gu
Xue
X
Yuan
Zhong
Z
D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D001921:Brain / Q000201:enzymology; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000737:chemistry / Q000302:isolation & purification; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D013552:Swine
D017705:Lignans; D010936:Plant Extracts; D015842:Serine Proteinase Inhibitors; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases