Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.
The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.
Sulaiman
M R
MR
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Perimal
E K
EK
Akhtar
M N
MN
Mohamad
A S
AS
Khalid
M H
MH
Tasrip
N A
NA
Mokhtar
F
F
Zakaria
Z A
ZA
Lajis
N H
NH
Israf
D A
DA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D027343:Rhizome; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D030521:Zingiberaceae / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; C403304:zerumbone; D002351:Carrageenan