title: Isolation and synthesis of flavonols and comparison of their antioxidant activity.
abstract: Phytochemical investigation of the leaves of Astragalus beckari yielded four flavonol aglycones, namely kaempferol, quercetin, 5-deoxy kaempferol and fisitin. These isolated compounds were then synthesised in the laboratory using the Algar-Flyn-Oyamad reaction. Antioxidant activity of both the isolated and synthesised flavonoids was compared using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. The isolated flavonoids were found to be more active.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan. hassaan2@super.net.pk
authors.forename: Aurangzeb
authors.initials: A
authors.lastname: Hasan
authors.forename: A
authors.initials: A
authors.lastname: Sadiq
authors.forename: A
authors.initials: A
authors.lastname: Abbas
authors.forename: E
authors.initials: E
authors.lastname: Mughal
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D027883:Astragalus Plant / Q000737:chemistry*; D044948:Flavonols / Q000138:chemical synthesis* / Q000737:chemistry*; D044949:Kaempferols / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000975:Antioxidants; D044948:Flavonols; D044949:Kaempferols; C006552:kaempferol; D011794:Quercetin