title: Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (> or =100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.
authors.affiliation: National Cancer Institute, Bethesda, Maryland 20852, USA.
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Jacobs
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.forename: Dai
authors.initials: D
authors.lastname: Qi
authors.forename: Alpa V
authors.initials: AV
authors.lastname: Patel
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Lynn R
authors.initials: LR
authors.lastname: Wilkins
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: Chinonye
authors.initials: C
authors.lastname: Harvey
authors.forename: Richard
authors.initials: R
authors.lastname: Hayes
authors.forename: Sandra
authors.initials: S
authors.lastname: Clipp
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Lonn
authors.initials: L
authors.lastname: Irish
authors.forename: Karen
authors.initials: K
authors.lastname: Koenig
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D014807:Vitamin D