title: Bladder cancer mortality of workers exposed to aromatic amines: a 58-year follow-up.
abstract: We previously investigated bladder cancer risk in a cohort of dyestuff workers who were heavily exposed to aromatic amines from 1922 through 1972. We updated the follow-up by 14 years (through 2003) for 590 exposed workers to include more than 30 years of follow-up since last exposure to aromatic amines. Expected numbers of deaths from bladder cancer and other causes were computed by use of national mortality rates from 1951 to 1980 and regional mortality rates subsequently. There were 394 deaths, compared with 262.7 expected (standardized mortality ratio = 1.50, 95% confidence interval = 1.36 to 1.66). Overall, 56 deaths from bladder cancer were observed, compared with 3.4 expected (standardized mortality ratio = 16.5, 95% confidence interval = 12.4 to 21.4). The standardized mortality ratio for bladder cancer increased with younger age at first exposure and increasing duration of exposure. Although the standardized mortality ratio for bladder cancer steadily decreased with time since exposure stopped, the absolute risk remained approximately constant at 3.5 deaths per 1000 man-years up to 29 years after exposure stopped. Excess risk was apparent 30 years or more after last exposure.
authors.affiliation: Department of Traumatology, Orthopaedics and Occupational Medicine, University of Turin, Turin, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Pira
authors.forename: Giorgio
authors.initials: G
authors.lastname: Piolatto
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.forename: Canzio
authors.initials: C
authors.lastname: Romano
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Loren
authors.initials: L
authors.lastname: Lipworth
authors.forename: Joseph K
authors.initials: JK
authors.lastname: McLaughlin
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000588:Amines / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000401:mortality*
chemical_list: D000588:Amines; D002273:Carcinogens