title: MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord.
abstract: In the developing CNS, neurons and glia are sequentially produced from the ventricular neural progenitor cells. One fundamental question in developmental neurobiology is what signals or factors control the developmental switch from neurogenesis to gliogenesis. Here we report that microRNAs (miRNAs) play an essential role in this important developmental process. Inhibition of miRNA formation in Olig1(Cre)-mediated Dicer conditional knock-out mice disrupted both oligodendrogenesis and astrogliogenesis in the ventral neuroepithelial cells. By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue.
authors.affiliation: College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zheng
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.forename: Mengsheng
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D019521:Body Patterning / Q000235:genetics; D002452:Cell Count; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D053487:DEAD-box RNA Helicases / Q000172:deficiency; D004622:Embryo, Mammalian; D004722:Endoribonucleases / Q000172:deficiency; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000235:genetics*; D051796:Inhibitor of Differentiation Proteins / Q000494:pharmacology; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D046569:Neuroepithelial Cells / Q000502:physiology*; D055495:Neurogenesis / Q000235:genetics*; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000502:physiology*; D043244:Ribonuclease III; D013116:Spinal Cord / Q000166:cytology* / Q000196:embryology*
chemical_list: D000906:Antibodies; D051792:Basic Helix-Loop-Helix Proteins; D053487:DEAD-box RNA Helicases; D004722:Endoribonucleases; D051796:Inhibitor of Differentiation Proteins; D035683:MicroRNAs; D009419:Nerve Tissue Proteins; D043244:Ribonuclease III; C494786:Olig1 protein, mouse; C067679:Idb3 protein, mouse; C509781:Dicer1 protein, mouse