[Troponin in the diagnosis of myocardial infarction: An approach from the Clinical Laboratory].
Among the many biomarkers studied to evaluate myocardial damage, troponin is considered the most sensitive and specific. However, current methodologies present pre-analytical, analytical and post-analytical problems, of which the more significant are the lack of standardization and a high uncertainty in the level of decision or cut-off. It is hoped that a new generation of assays called "ultra sensitive" will improve analytical performance characteristics of the technique and achieve compliance with the internationally recommended quality specifications.
Guzmán D
Ana María
AM
Departamento de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Quiroga G
Teresa
T
D015415:Biomarkers / Q000097:blood; D006801:Humans; D007118:Immunoassay / Q000379:methods / Q000592:standards*; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D014336:Troponin / Q000097:blood*
D015415:Biomarkers; D014336:Troponin