title: Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells.
abstract: Prostate cancer is the fifth most common neoplasm worldwide, and the second most common cancer among men. Ginsenosides, the main component of ginseng, have been known for their medicinal effects such as anti-inflammatory and anti-proliferative activities. In this study, we investigated the inhibitory effects of ginsenosides (ginsenoside 20(R)-Rh2 and ginsenoside 20(S)-Rh2) on prostate cancer cells in vitro. Only ginsenoside 20(S)-Rh2 showed proliferation inhibition on androgen-dependent and -independent prostate cancer cells. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in antitumor activities.
authors.affiliation: Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hongshan
authors.initials: H
authors.lastname: Yu
authors.forename: Chunzhi
authors.initials: C
authors.lastname: Zhang
authors.forename: Fengxie
authors.initials: F
authors.lastname: Jin
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Kondo
mesh_terms: D000728:Androgens / Q000378:metabolism; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000728:Androgens; D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; D010936:Plant Extracts; C055305:ginsenoside Rh2