title: [Postoperative analgesia for hepatic cryosurgery].
abstract: BACKGROUND
  Hepatic cryosurgery is an alternative therapeutic choice for patients who are not eligible for surgical liver resection. As this procedure sometimes causes postoperative bleeding tendency, we investigated indication of intravenous patient-controlled analgesia (IVPCA) after this surgery.
  
  
  METHODS
  We measured pre- and postoperative platelet counts, coagulation profile and postoperative pain with IVPCA in 8 patients.
  
  
  RESULTS
  Platelet counts decreased from 9.83 +/- 5.38 (x 10(3) x ml(-1)) to 5.91 +/- 4.56 (x10(3) x ml(-1)) postoperatively (P<0.01) and the maximum relative decrease was 72%. Platelet counts reached the maximum depression from 1 to 3 POD and in two patients it did not recover by 7 POD. Percentage of prothrombin activity decreased from 79.5 +/- 10.4 to 65.9 +/- 13.2 (P<0.01), with the nadir observed from 0 POD to 2 POD. In this study it was difficult to predict the extent of postoperative bleeding tendency beforehand. IVPCA with morphine provided adequate analgesia at rest. Althogh pain on moving seemed rather difficult to treat in two patients, IVPCA also helped patients walk with VAS score less than 55 mm in other patients.
  
  
  CONCLUSIONS
  Considering the risk of bleeding tendency and epidural hematoma, we recommend IVPCA with opioid for postoperative pain in patients after hepatic cryosurgery instead of epidural analgesia and non-steroidal anti-inflammatory drugs.
authors.affiliation: Department of Anesthesiology, School of Medicine, Keio University, Tokyo 160-8582.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Onishi
authors.forename: Saori
authors.initials: S
authors.lastname: Hashiguchi
authors.forename: Hiroka
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Eileen Naomi
authors.initials: EN
authors.lastname: Ogawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Shizuko
authors.initials: S
authors.lastname: Kosugi
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuzaki
authors.forename: Junzo
authors.initials: J
authors.lastname: Takeda
mesh_terms: D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D003452:Cryosurgery; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010976:Platelet Count; D011182:Postoperative Care; D019106:Postoperative Hemorrhage; D012306:Risk
chemical_list: D000701:Analgesics, Opioid