Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.
Cummins
Nathan W
NW
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Jiang
Wei
W
McGinty
John
J
Bren
Gary D
GD
Bosch
Ronald J
RJ
Landay
Alan
A
Deeks
Steven G
SG
Martin
Jeffrey N
JN
Douek
Daniel
D
Lederman
Michael M
MM
Brenchley
Jason
J
Badley
Andrew D
AD
D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry* / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D053181:Caspase 8 / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019562:Viral Load
C505530:CASP8 protein, human; D053181:Caspase 8