title: Adjuvant high-dose interferon-{alpha} for resected melanoma in a patient with HIV infection.
abstract: Adjuvant interferon (IFN)-alpha remains the standard adjuvant therapy for intermediate and high-risk melanoma after definitive surgical resection. Data addressing the role and safety of adjuvant immunotherapy in HIV-infected patients with melanoma are lacking. We report on an HIV(+) patient who received IFN-alpha as adjuvant treatment for high-risk melanoma. To our knowledge, this is the first reported case of such an approach.
authors.affiliation: Section of Hematology and Medical Oncology, Department of Medicine, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, Box T4M-2, New Orleans, Louisiana 70112, USA.
authors.forename: Nakhle S
authors.initials: NS
authors.lastname: Saba
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: George
authors.forename: Brian C
authors.initials: BC
authors.lastname: Boulmay
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D017613:Iodine Compounds / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D037981:Neck Dissection; D011859:Radiography; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013964:Thyroid Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D013965:Thyroidectomy
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha; D017613:Iodine Compounds; D019275:Radiopharmaceuticals