Skeletal diversity via cationic rearrangements of substituted dihydropyrans.
Substituted dihydropyrans, easily accessed from a commercially available glycal, undergo acid-catalyzed rearrangement to provide highly functionalized isochroman and dioxabicyclooctane scaffolds.
Medeiros
Matthew R
MR
Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Narayan
Radha S
RS
McDougal
Nolan T
NT
Schaus
Scott E
SE
Porco
John A
JA
D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D004987:Ethers; D011714:Pyrans / Q000737:chemistry*
D000475:Alkenes; D004987:Ethers; D011714:Pyrans