title: Bifunctional agents for imaging and therapy.
abstract: Multiple, complementary techniques for tumor detection, including magnetic resonance, nuclear and optical imaging, are under active development; each approach has particular strengths and advantages. Efforts are also currently underway to develop bifunctional agents, so that a single molecule can be used for imaging, therapy, and monitoring the long-term tumor response. This chapter is mainly focused on illustrating the utility of certain tumor-avid photosensitizers in developing agents for tumor imaging [fluorescence, magnetic resonance imaging (MRI), positron emission tomography (PET)] and photodynamic therapy. Recent approaches for developing target-specific agents for photodynamic therapy (PDT) and in vivo tumor imaging are also briefly discussed.
authors.affiliation: PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Pandey
authors.forename: Nadine S
authors.initials: NS
authors.lastname: James
authors.forename: Yihui
authors.initials: Y
authors.lastname: Chen
authors.forename: Joseph
authors.initials: J
authors.lastname: Missert
authors.forename: Munawar
authors.initials: M
authors.lastname: Sajjad
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D013050:Spectrometry, Fluorescence; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents