Medicated chewing gum--a potential drug delivery system.
BACKGROUND
Over the years, patient convenience and patient compliance-orientated research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which, medicated chewing gum (MCG) offers a highly convenient patient-compliant way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation.


METHODS
In this review, various formulation ingredients, different manufacturing processes, and assessment of in vivo and in vitro drug release from MCG are thoroughly discussed along with the therapeutic potential and limitations of MCG.


RESULTS
Readers will gain knowledge about the rationale and prominent formulation and performance evaluation strategies behind chewing gum as a drug delivery system.


CONCLUSIONS
The availability of directly compressible co-processed gum material enables rapid, safe and low-cost development of MCG as a drug delivery option. By MCG formulation, revitalization of old products and reformulation of new patented products is possible, to differentiate them from upcoming generics competition in the market.
Chaudhary
Shivang A
SA
National Institute of Pharmaceutical Education and Research-Ahmedabad, C/o. BV Patel Pharmaceutical Education and Research Development Center, Department of Pharmaceutics, SG Highway, Thaltej, Ahmedabad-380054, India.
Shahiwala
Aliasgar F
AF
D002638:Chewing Gum; D016503:Drug Delivery Systems; D006801:Humans
D002638:Chewing Gum