title: T regulatory cells and transplantation tolerance.
abstract: Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation. The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Gorantla
authors.forename: Stefan
authors.initials: S
authors.lastname: Schneeberger
authors.forename: Gerald
authors.initials: G
authors.lastname: Brandacher
authors.forename: Robert
authors.initials: R
authors.lastname: Sucher
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: W P Andrew
authors.initials: WP
authors.lastname: Lee
authors.forename: Xin Xiao
authors.initials: XX
authors.lastname: Zheng
mesh_terms: D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology; D023001:Transplantation Tolerance; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents