[Experimental study of animal cabin with ATM/LP and low oxygen and high carbon dioxide].
OBJECTIVE
To explore the feasibility of the animal experimental cabin to copy the animal models with ATM/LP and low oxygen and high carbon dioxide environment.


METHODS
60 SPF-class male SD rats were divided into two groups, 20 for normobaric hypoxia control experiments and the other 40 for hypobaric hypoxia control experiments. For each group, examine the pulmonary arterial pressure and carotid arterial pressure indicators of rats by using the multi-detector measurement of physiological, and observe the pulmonary vascular changes in the structure.


RESULTS
The ATM/LP and low oxygen and high carbon dioxide environment can promote the formation of pulmonary hypertension and accelerate changes in pulmonary vascular remodeling, promoting right ventricular hypertrophy.


CONCLUSIONS
Clinical applications showed that the animal experimental cabin was observing and controlling accurately, safe, reliable, and the results was reproducible. It can successfully copy the regular low-pressure hypoxia and hypercapnia environment pulmonary hypertension model, in order to study the physiological mechanism of a variety of circulation and respiratory diseases caused by oxygen-poor and provide an experimental technology platform.
Chong
Yinbao
Y
Equipment Division of Xinqiao Hospital, Third Military Medical University, Chongqing 400037. chongyinbao@163.net
Liu
Jiuling
J
Zhao
An
A
Wang
Qing
Q
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D004195:Disease Models, Animal; D004780:Environment, Controlled; D004867:Equipment Design; D000860:Hypoxia; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D012891:Sleep Apnea Syndromes
D002245:Carbon Dioxide; D010100:Oxygen