Luteinizing-hormone releasing hormone therapy and the risk of death from Alzheimer disease.
OBJECTIVE
We evaluated the risk of death from Alzheimer disease (AD) in men with prostate cancer undergoing treatment with or without a luteinizing-hormone releasing hormone (LHRH) agonist.


METHODS
Between 1997 and 2007, 6,647 men were treated with brachytherapy for prostate cancer with (N = 1,700) or without (N = 4,947) LHRH agonist therapy. Competing risks multivariable regression was performed to assess whether the use of a LHRH agonist was associated with the risk of death from AD adjusting for the presence of mild AD and age at presentation and known prostate cancer prognostic factors.


RESULTS
After a median follow-up of 4.1 years, 1.2% (81/6,647) of the study cohort died from AD accounting for 16% (81/506) of all observed mortality. There was a significant reduction in the risk of death from AD in men who were treated with a LHRH agonist for a median of 4.0 months as compared with those who were not [adjusted hazard ratio: 0.45 (95% confidence interval, 0.25-0.83); P = 0.01].


CONCLUSIONS
LHRH agonist use as compared with no use in men with prostate cancer was associated with a decreased risk of death from AD.
D'Amico
Anthony V
AV
Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA, USA. adamico@partners.org
Braccioforte
Michelle H
MH
Moran
Brian J
BJ
Chen
Ming-Hui
MH
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications / Q000401:mortality*; D015415:Biomarkers / Q000097:blood; D001918:Brachytherapy; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011471:Prostatic Neoplasms / Q000097:blood / Q000150:complications / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D016019:Survival Analysis; D013997:Time Factors
D015415:Biomarkers; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone