title: Glucose transporter expression of an esophageal gastrointestinal tumor detected by F-18 FDG PET/CT.
abstract: A 74-year-old woman had dysphagia and underwent esophagogastroduodenoscopy. A giant submucosal tumor was seen from the middle to the lower esophagus. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG-PET/CT) was performed and F-18 FDG was found to accumulate in the submucosal tumor. The maximum standardized uptake value of the early phase was 4.93 and that of the delayed phase was 6.48. Gastrointestinal stromal tumor (GIST) was confirmed by both fine needle aspiration under endoscopic ultrasound and postoperative histopathologic findings. We stained the postoperative histopathologic specimen to investigate glucose transporter (GLUT) expression using immunohistochemistry, which revealed that GLUT-1 had a weak expression on membranes and GLUT-4 had a strong expression on membranes or in cytoplasm. GLUT-3 had no expression on membranes or in cytoplasm. Esophageal GIST is rare and the relationship between GLUT expression and F-18 FDG accumulation in GIST is probably rare.
authors.affiliation: Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan. hayato@med.kurume-u.ac.jp
authors.forename: Hayato
authors.initials: H
authors.lastname: Kaida
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Miya
authors.initials: M
authors.lastname: Yuzuriha
authors.forename: Seiji
authors.initials: S
authors.lastname: Kurata
authors.forename: Syunji
authors.initials: S
authors.lastname: Arikawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawahara
authors.forename: Jun
authors.initials: J
authors.lastname: Uozumi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Uchida
authors.forename: Maiko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Fujita
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hayabuchi
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D011859:Radiography; D014055:Tomography, Emission-Computed
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D019788:Fluorodeoxyglucose F18