title: Supply of precursors for carotenoid biosynthesis in plants.
abstract: Carotenoids are isoprenoids of industrial and nutritional interest produced by all photosynthetic organisms, including plants. Too often, the metabolic engineering of plant carotenogenesis has been obstructed by our limited knowledge on how the endogenous pathway interacts with other related metabolic pathways, particularly with those involved in the production of isoprenoid precursors. However, recent discoveries are providing new insights into this field. All isoprenoids derive from prenyl diphosphate precursors. In the case of carotenoids, these precursors are produced predominantly by the methylerythritol 4-phosphate (MEP) pathway in plants. This review focuses on the progress in our understanding of how manipulation of the MEP pathway impacts carotenoid biosynthesis and on the discoveries underlining the central importance of coordinating the supply of MEP-derived precursors with the biosynthesis of carotenoids and other derived isoprenoids.
authors.affiliation: Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB, Jordi Girona 18, 08034 Barcelona, Spain. mrcgmp@cid.csic.es
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez-Concepción
mesh_terms: D002338:Carotenoids / Q000378:metabolism*; D004896:Erythritol / Q000031:analogs & derivatives / Q000378:metabolism; D059828:Plant Cells; D010944:Plants / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism
chemical_list: C114232:2-C-methylerythritol 4-phosphate; D013403:Sugar Phosphates; D002338:Carotenoids; D004896:Erythritol