title: Anti-osteoporotic constituents from Indian medicinal plants.
abstract: The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, M. G. Road, Lucknow 226001, Uttar Pradesh, India.
authors.forename: Manmeet
authors.initials: M
authors.lastname: Kumar
authors.forename: Preeti
authors.initials: P
authors.lastname: Rawat
authors.forename: Preeti
authors.initials: P
authors.lastname: Dixit
authors.forename: Devendra
authors.initials: D
authors.lastname: Mishra
authors.forename: Abnish K
authors.initials: AK
authors.lastname: Gautam
authors.forename: Rashmi
authors.initials: R
authors.lastname: Pandey
authors.forename: Divya
authors.initials: D
authors.lastname: Singh
authors.forename: Naibedya
authors.initials: N
authors.lastname: Chattopadhyay
authors.forename: Rakesh
authors.initials: R
authors.lastname: Maurya
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D032422:Cissus; D007194:India; D010006:Osteoblasts / Q000187:drug effects* / Q000502:physiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D029631:Sapindaceae; D020950:Vitex
chemical_list: D050071:Bone Density Conservation Agents; D010936:Plant Extracts