title: Relationship Between White Matter Integrity, Attention, and Memory in Schizophrenia: A Diffusion Tensor Imaging Study.
abstract: Attention and memory deficits are among the most prominent cognitive disturbances observed in schizophrenia. It has been suggested that a disruption in anatomical connectivity between areas involved in attentional control might be responsible for these abnormalities. We used Diffusion Tensor Tractography and Color Stroop/Negative Priming(NP) paradigm to investigate integrity of Cingulum Bundle(CB), the main white matter tract interconnecting these regions, and its relationship with executive functions in patients with schizophrenia and matched controls. The Fractional Anisotropy(FA), was calculated along the CB pathways, and correlated with reaction times for each Stroop item, and both Stroop, and NP effects. Patients with schizophrenia demonstrated decreased CB integrity and diminished NP effect, compared with controls, but both groups showed Stroop effect. For patients only, reaction times for every item, as well as for Stroop effect, correlated with left CB FA. These findings suggest that CB integrity disruptions might compromise the executive processes in schizophrenia.
authors.forename: Marek
authors.initials: M
authors.lastname: Kubicki
authors.forename: Margaret
authors.initials: M
authors.lastname: Niznikiewicz
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Connor
authors.forename: Lida
authors.initials: L
authors.lastname: Ungar
authors.forename: Paul
authors.initials: P
authors.lastname: Nestor
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bouix
authors.forename: Mark
authors.initials: M
authors.lastname: Dreusicke
authors.forename: Ron
authors.initials: R
authors.lastname: Kikinis
authors.forename: Robert
authors.initials: R
authors.lastname: McCarley
authors.forename: Martha
authors.initials: M
authors.lastname: Shenton