PPAR modulation of kinase-linked receptor signaling in physiology and disease.
Kinase-linked receptors and nuclear receptors connect external cues to gene transcription. Among nuclear receptors, peroxisome proliferator-activated receptors (PPARs) are of special interest in relation to widespread human diseases. Mapping out connections between PPARs and kinase-linked receptor signaling is central to better understand physiological and pathophysiological processes and to better define therapeutic strategies. This is the aim of the present review.
Rotman
Nicolas
N
Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland.
Wahli
Walter
W
D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D004194:Disease; D006801:Humans; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*; D010770:Phosphotransferases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D047492:Peroxisome Proliferator-Activated Receptors; D010770:Phosphotransferases