title: Lycopene absorption in humans after the intake of two different single-dose lycopene formulations.
abstract: Lycopene is the main carotenoid present in tomato and its derivatives. It can also be obtained from the fungus Blakeslea trispora and its use as novel food ingredient was recently approved. The aim of the present study was to investigate the absorption of lycopene, in humans, after the intake of a single dose providing 15mg of lycopene from tomato extract (oleoresin 6%) or B. trispora (oil suspension 6%). Twelve female subjects were enrolled and divided into two groups: group 1 was assigned to the sequence tomato lycopene/wash-out/B. trispora lycopene, whereas group 2 followed the sequence B. trispora lycopene/wash-out/tomato lycopene. The formulations were consumed early in the morning with 5mL of sunflower oil, 100g of bread and 150mL of water. Blood was collected before consumption and after 2, 4, 6, 8, 10, 12 and 24h. Plasma lycopene concentrations were determined by HPLC analysis. On the whole, statistical analysis of data did not demonstrate a different effect of the type of lycopene source on the carotenoid absorption. The maximum increase in plasma lycopene concentration was about 40nmol/L for both products at 10-12h (p<0.05) post-consumption and decreased to basal values at 24h. A transient higher increase in lycopene concentration at 4-6h (p<0.05) after tomato lycopene with respect to B. trispora lycopene intake was observed. In conclusion, the intake of a single dose of the two liposoluble lycopene formulations revealed a comparable, small, but significant increase in plasma lycopene concentrations.
authors.affiliation: Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Sezione Nutrizione, Università degli Studi di Milano, via Celoria 2, 20133 Milano, Italy. patrizia.riso@unimi.it
authors.forename: Patrizia
authors.initials: P
authors.lastname: Riso
authors.forename: Antonella
authors.initials: A
authors.lastname: Brusamolino
authors.forename: Daniele
authors.initials: D
authors.lastname: Contino
authors.forename: Daniela
authors.initials: D
authors.lastname: Martini
authors.forename: Stefano
authors.initials: S
authors.lastname: Vendrame
authors.forename: Cristian
authors.initials: C
authors.lastname: Del Bo'
authors.forename: Marisa
authors.initials: M
authors.lastname: Porrini
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000493:pharmacokinetics*; D002338:Carotenoids / Q000097:blood / Q000493:pharmacokinetics*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D000077276:Lycopene; D018551:Solanum lycopersicum / Q000737:chemistry; D009090:Mucorales / Q000737:chemistry
chemical_list: D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene