title: The importance of the small RNA chaperone Hfq for growth of epidemic Yersinia pestis, but not Yersinia pseudotuberculosis, with implications for plague biology.
abstract: Yersinia pestis, the etiologic agent of plague, has only recently evolved from Yersinia pseudotuberculosis. hfq deletion caused severe growth restriction at 37 degrees C in Y. pestis but not in Y. pseudotuberculosis. Strains from all epidemic plague biovars were similarly affected, implicating Hfq, and likely small RNAs (sRNAs), in the unique biology of the plague bacillus.
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY 12201-2002, USA.
authors.forename: Guangchun
authors.initials: G
authors.lastname: Bai
authors.forename: Andrey
authors.initials: A
authors.lastname: Golubov
authors.forename: Eric A
authors.initials: EA
authors.lastname: Smith
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: McDonough
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D035001:Host Factor 1 Protein / Q000235:genetics / Q000378:metabolism*; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism; D013696:Temperature; D015010:Yersinia pestis / Q000201:enzymology* / Q000254:growth & development*; D015011:Yersinia pseudotuberculosis / Q000201:enzymology* / Q000254:growth & development*
chemical_list: D001426:Bacterial Proteins; D035001:Host Factor 1 Protein; D018832:Molecular Chaperones; D012329:RNA, Bacterial