Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy.
In infants with hypoxic-ischemic encephalopathy, cooling reduces death/neurodevelopmental impairment, whereas prophylactic anticonvulsants may not. This retrospective analysis shows no reduction in neurodevelopmental impairment (23% in prophylactic phenobarbital group vs 45% in controls, P = .3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001).
Meyn
Donald F
DF
Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA. don.meyn@infamedics.com
Ness
Jayne
J
Ambalavanan
Namasivayam
N
Carlo
Waldemar A
WA
D000927:Anticonvulsants / Q000627:therapeutic use; D002675:Child, Preschool; D003080:Cold Temperature; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000517:prevention & control / Q000628:therapy*; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D012189:Retrospective Studies; D013696:Temperature; D016896:Treatment Outcome
D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D010634:Phenobarbital