title: Childhood adversities, adulthood life events and depression.
abstract: BACKGROUND
  The role of childhood adversities in predicting adulthood depression has been suggested to be complex and in need of additional comprehensive studies.
  
  
  OBJECTIVE
  This investigation set out to examine whether increased exposure to life events (LEs) in adulthood mediates the association between childhood adversities and adulthood depression.
  
  
  METHODS
  This study is based on a random health survey sample from the Finnish working-aged population (n=16,877) with a follow-up of up to 7 years. Depression was identified by Beck Depression Inventory, records of antidepressant prescriptions and hospitalization due to depression obtained from national health registers.
  
  
  RESULTS
  Childhood adversities were associated with an increased likelihood of experiencing a high number of LEs in adulthood and their perceived burdensomeness. The mean number of new LEs correlated significantly (P<0.001) in a dose-response relationship with the number of childhood adversities. Reporting childhood adversities was associated with a 1.28-2.70-fold increase in the odds of depression as indicated by BDI score, a 1.29-1.94-fold increase in the rate of antidepressant prescriptions and a 1.17-4.04-fold increase in the risk of hospitalization due to depression. Adjustment for new LE attenuated these associations by 21-24%, but did not render them insignificant.
  
  
  CONCLUSIONS
  Increased exposure to adult negative life events proximal to adult depression may partially explain the association between childhood adversities and adult depression.
authors.affiliation: Department of Psychiatry, University of Turku, Satakunta Hospital District, Finland. jyrki.korkeila@utu.fi
authors.forename: Jyrki
authors.initials: J
authors.lastname: Korkeila
authors.forename: Jussi
authors.initials: J
authors.lastname: Vahtera
authors.forename: Hermann
authors.initials: H
authors.lastname: Nabi
authors.forename: Mika
authors.initials: M
authors.lastname: Kivimäki
authors.forename: Katariina
authors.initials: K
authors.lastname: Korkeila
authors.forename: Markku
authors.initials: M
authors.lastname: Sumanen
authors.forename: Karoliina
authors.initials: K
authors.lastname: Koskenvuo
authors.forename: Markku
authors.initials: M
authors.lastname: Koskenvuo
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D000928:Antidepressive Agents / Q000627:therapeutic use; D002648:Child; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology*; D054541:Family Conflict / Q000523:psychology*; D005387:Finland; D006760:Hospitalization; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008875:Middle Aged; D011610:Psychosocial Deprivation; D012307:Risk Factors; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents