Thiazolidinediones as a novel class of algicides against red tide harmful algal species.
This paper reports the synthesis of 28 thiazolidinedione derivatives along with their algicidal activity against microalgae causing harmful algal blooming. Among the 28 compounds tested, most showed effective algicidal activity against Heterosigma akashiwo, Chattonella marina, and Cochlodinium polykrikoides, while non-harmful algae were relatively tolerant to these thiazolidinedione derivatives. Compounds 6, 13, and 22 were the most potent against C. polykrikoides with IC₅₀ values <0.5 µM. Among the thiazolidinedione derivatives tested, compounds 7, 13, 27, and 28 were extremely competent and selective to C. polykrikoides with IC₅₀ values ranging from 0.1 to 2 µM, while C. marina and H. akashiwo showed an IC₅₀ value ranging from 30 to 130 µM. These results show that some thiazolidinedione derivatives can act as potent algicides against harmful algal blooms.
Kim
Yeon-Mi
YM
Department of Life Science and Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, South Korea.
Wu
Ying
Y
Duong
Thi Uyen
TU
Ghodake
Gajanan S
GS
Kim
Si Wouk
SW
Jin
Eonseon
E
Cho
Hoon
H
D056890:Eukaryota / Q000187:drug effects* / Q000254:growth & development; D057097:Harmful Algal Bloom / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000494:pharmacology*
D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione