Oxime-derived palladacycles as source of palladium nanoparticles.
Oxime-derived palladacycles are very efficient and versatile pre-catalysts for a wide range of carbon-carbon bond coupling reactions in air, under very low loading conditions, and employing reagent-grade chemicals. This tutorial review presents the main achievements, advantages and limitations of oxime palladacycles as a source of highly active palladium nanoparticles for high-turnover catalyzed Heck, as well as other homo- and cross-coupling reactions usually carried out employing organic or aqueous solvents. Comparison with other ligandless Pd(II) catalysts is also presented. Recent advances to develop supported oxime-derived palladacycles in order to facilitate precatalyst recovery and reuse in cross-coupling reactions, especially under aqueous reaction conditions, are also discussed.
Alonso
Diego A
DA
Instituto de Síntesis Orgánica and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain. diego.alonso@ua.es
Nájera
Carmen
C