Multiple hydrogen-bond-mediated molecular duplexes based on the self-complementary amidourea motif.
The self-complementary amidourea motif, which was stabilized by four intermolecular tricenter hydrogen bonds, was investigated in solution and in the solid state. Extensive studies on oligomer 2 indicated that the hydrogen-bonding mode could persist in longer molecular duplexes based on the amidourea motif. The dimerization constants of 2b.2b in various DMSO-d(6)/CDCl(3) mixtures were determined quantitatively by (1)H NMR dilution studies, which suggested that the homoduplex was highly stable in low polar solvents.
Chu
Wei-Jun
WJ
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yang
Yong
Y
Chen
Chuan-Feng
CF
D000577:Amides / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D014508:Urea / Q000737:chemistry*
D000577:Amides; D014508:Urea