title: Impact of antenatal selective serotonin reuptake inhibitor exposure on pregnancy outcomes in mice.
abstract: OBJECTIVE
  This study investigates fluoxetine (FLX) exposure as an etiology for altered gestational length and adverse pregnancy outcomes.
  
  
  METHODS
  Two experiments were performed exposing mice to drinking water (H(2)O) or H(2)O+FLX. Primary outcomes included gestational length, litter size, and live birth rate. In experiment 1, time-mated dams were monitored for spontaneous birth, and gestational length was calculated. In experiment 2, dams were dissected on day 14 to verify litter size and qualities of embryo implantation.
  
  
  RESULTS
  There was no difference in gestational length between H(2)O dams (480.7 ± 13.2 hours) and H(2)O+FLX dams (483.5 ± 10.1 hours), P = .70. Mean litter size was decreased in H(2)O+FLX dams (4.1 ± 1.3/litter) compared to H(2)O dams (5.5 ± 1.9/litter), P = .04. H(2)O+FLX dams were less likely to have live births (25.4%) compared to H(2)O dams (49.3%), P = .01.
  
  
  CONCLUSIONS
  Antenatal FLX exposure did not statistically alter gestational length, but did affect litter size and spontaneous loss in mice. This warrants further investigation.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. stb2119@columbia.edu
authors.forename: Samuel
authors.initials: S
authors.lastname: Bauer
authors.forename: Catherine
authors.initials: C
authors.lastname: Monk
authors.forename: Mark
authors.initials: M
authors.lastname: Ansorge
authors.forename: Cynthia
authors.initials: C
authors.lastname: Gyamfi
authors.forename: Michael
authors.initials: M
authors.lastname: Myers
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology; D001723:Birth Rate; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D008098:Litter Size; D050498:Live Birth; D051379:Mice; D011247:Pregnancy; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors