Genetic and functional study of the IPO5 gene in schizophrenia.
The present work reported on a weak association of the importin 5 (IPO5) gene with schizophrenia in combined family and case-control samples and also investigated a possible mechanism by which the IPO5 gene may contribute to the development of the disease in a Chinese population. Our results suggest that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia.
Wang
Zhen-Qi
ZQ
Research Center for Genomic Medicine and MH Radiobiology Research Unit, Jilin University, Changchun 130021, China.
Liu
Yang
Y
Wu
Ning
N
Xu
Qi
Q
Jin
Shun-Zi
SZ
Ju
Gui-Zhi
GZ
Ye
Lin
L
Liu
Li-Bo
LB
Zhang
Xuan
X
Wu
Jiang
J
D000328:Adult; D002681:China; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D028961:beta Karyopherins / Q000235:genetics*
C107940:IPO5 protein, human; D028961:beta Karyopherins