title: Computed tomography as a tool for percutaneous coronary intervention of chronic total occlusions.
abstract: Chronic total occlusions (CTO) constitute a major challenge in percutaneous coronary revascularisation (PCI). The development of new interventional strategies, the availability of purpose made tools including dedicated catheters and wires, as well as increasing expertise by the operators, have contributed to the modest success rates which today hover around 75%. Case selection is of utmost importance since failure of this high risk procedure with its typically high radiation doses, high contrast doses and increased complication rates is associated with long term adverse events. Imaging of the coronary arteries using the gold standard of invasive coronary angiography allows characterisation of the chronic total occlusion and is often able to predict the probability of successful recanalisation. Multislice computed tomography (MSCT) is increasingly being utilised as a non-invasive diagnostic imaging modality to detect coronary artery disease. Its ability to provide information on the soft tissue (including plaque) surrounding the lumen has been applied to better define the morphological features of CTOs. In fact, the amount of calcification, tortuosity and actual length of the occluded segment which are established predictors of success, are all better characterised by MSCT. Three dimensional reconstruction of the coronary anatomy and its integration with two dimensional fluoroscopy images during the actual CTO-PCI procedure may help to identify the best angiographic projection, offering a directional guide at the angiographically "missing segment". More technological advances are needed to optimise this multi-modality imaging integration. Whether this will result in better success rates for CTO-PCI is still the subject of ongoing research. It is then that we can evaluate the true benefit of the use of MSCT for CTO against the risk from excessive radiation associated with this strategy.
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Michael
authors.initials: M
authors.lastname: Magro
authors.forename: Carl
authors.initials: C
authors.lastname: Schultz
authors.forename: Cihan
authors.initials: C
authors.lastname: Simsek
authors.forename: Hector M
authors.initials: HM
authors.lastname: Garcia-Garcia
authors.forename: Evelyn
authors.initials: E
authors.lastname: Regar
authors.forename: Koen
authors.initials: K
authors.lastname: Nieman
authors.forename: Nico
authors.initials: N
authors.lastname: Mollet
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: van Geuns
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation / Q000379:methods*; D002908:Chronic Disease; D017023:Coronary Angiography / Q000009:adverse effects / Q000379:methods*; D054059:Coronary Occlusion / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D008280:Magnetics; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted; D015641:Radiography, Interventional; D015607:Stents; D013813:Therapy, Computer-Assisted; D014057:Tomography, X-Ray Computed / Q000009:adverse effects; D016896:Treatment Outcome