HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes.
BACKGROUND
Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS).


OBJECTIVE
To identify genetic risk factors for Hu-PNS and investigate the role of T cells.


METHODS
HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC).


RESULTS
The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC.


CONCLUSIONS
This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.
de Graaf
Marieke T
MT
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
de Beukelaar
Janet W K
JW
Haasnoot
Geert W
GW
Levering
Wilfried H B M
WH
Rogemond
Véronique
V
Didelot
Adrien
A
Honnorat
Jérôme
J
Gratama
Jan W
JW
Smitt
Peter A E Sillevis
PA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D016001:Confidence Intervals; D051959:ELAV Proteins / Q000276:immunology*; D005260:Female; D006683:HLA-DQ Antigens / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020361:Paraneoplastic Syndromes, Nervous System / Q000276:immunology* / Q000473:pathology; D055752:Small Cell Lung Carcinoma / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
D000906:Antibodies; D015704:CD4 Antigens; D051959:ELAV Proteins; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen