Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia.
Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID.
Kleiner-Fisman
Galit
G
Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. gkleinerfisman@yahoo.com
Lozano
Andres
A
Moro
Elena
E
Poon
Yu-Yan
YY
Lang
Anthony E
AE
D000978:Antiparkinson Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D046690:Deep Brain Stimulation / Q000379:methods; D004409:Dyskinesia, Drug-Induced / Q000601:surgery*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008137:Longitudinal Studies; D008297:Male; D053860:Pallidotomy / Q000379:methods*; D010300:Parkinson Disease / Q000188:drug therapy / Q000601:surgery; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D000978:Antiparkinson Agents; D007980:Levodopa