title: Chemical constituents from Delphinium chrysotrichum and their biological activity.
abstract: A new diterpene alkaloid named delphatisine C (1) has been isolated from aerial parts of Delphinium chrysotrichum along with three known norditerpenoid alkaloids delpheline (2), delbrunine (3), and delectinine (4). Their structures were characterized on the basis of their spectral data. All of them were determined by SRB assay for their cytotoxicity, and compound (1) showed significant cytotoxic activities (IC(50)=2.36 μmol/L) against the A549 cell line.
authors.affiliation: Department of Applied Chemistry, Xi'an University of Technology, Xi'an 710054, PR China. hyq7978863@163.com
authors.forename: Yang-Qing
authors.initials: YQ
authors.lastname: He
authors.forename: Zhan-Ying
authors.initials: ZY
authors.lastname: Ma
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Wei
authors.forename: Bao-Zhong
authors.initials: BZ
authors.lastname: Du
authors.forename: Zhan-Xin
authors.initials: ZX
authors.lastname: Jing
authors.forename: Bing-Hua
authors.initials: BH
authors.lastname: Yao
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Gao
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D031882:Delphinium / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D015394:Molecular Structure; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C557535:delphatisine C