[Correlation of angiotensin-converting enzyme 2 gene polymorphism with antihypertensive effects of benazepril].
OBJECTIVE
To explore the correlation of rs2106809 from angiotensin-converting enzyme 2 gene with antihypertensive effects of benazepril, as well as its interactions with polymorphisms of angiotensinogen(AGT) and angiotensin II type 1 receptor(AGTR1) gene.


METHODS
Correlation between rs2106809 and blood pressure reduction was estimated based on a field trail with 1 831 hypertensive patients using benazepril for 2 weeks. Generalized multifactor dimensionality reduction (GMDR) was used to explore the interactions of rs2106809 and 8 single nucleotide polymorphisms (SNPs) of AGTR1 gene and 3 SNPs of AGT gene.


RESULTS
rs2106809 was found to be associated with reduction in systolic blood pressure and pulse pressure in women, as well as pulse pressure reduction in men. T allele carriers presented more blood pressure reduction (1.4, 1.3 and 0.9 mmHg/T allele respectively). Gene-gene interactions involving rs2106809 were found in systolic blood pressure reduction of men, and the response to benazepril of non-sensitive genotypes carriers was 8.2 (95% confidence interval: 6.6-9.7) mmHg, lower than that of sensitive genotypes carriers.


CONCLUSIONS
rs2106809 might act as an independent influencing factor or component of gene-gene interaction in blood pressure reducing effects of benazepril.
Chen
Qing
Q
Department of Epidemiology & Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Tang
Xun
X
Yu
Can-qing
CQ
Chen
Da-fang
DF
Tian
Jun
J
Cao
Yang
Y
Fan
Wen-yi
WY
Cao
Wei-hua
WH
Zhan
Si-yan
SY
Lv
Jun
J
Guo
Xiao-xia
XX
Li
Li-ming
LM
Hu
Yong-hua
YH
D000328:Adult; D000368:Aged; D000085962:Angiotensin-Converting Enzyme 2; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001552:Benzazepines / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics
D000959:Antihypertensive Agents; D001552:Benzazepines; D044140:Receptor, Angiotensin, Type 1; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2; C044946:benazepril