title: Are presynaptic proteins predisposed to self-assemble?
abstract: Tight control of synapse formation ensures that neurons connect to appropriate targets. In this issue of Neuron, Klassen et al. identify ARL-8 GTPase as a regulator of presynaptic assembly. Without ARL-8, presynaptic material aggregates en route to its destination, suggesting that ARL-8 acts like a dispersant to prevent premature synaptic assembly in the axon.
authors.affiliation: FM Kirby Neurobiology Center of Children's Hospital, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Ann Y N
authors.initials: AY
authors.lastname: Goldstein
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Schwarz