title: Extracranial vertebral artery involvement in neurofibromatosis type I. Report of four cases and literature review.
abstract: Neurofibromatosis type 1 (NF-1) is one of the most common inherited diseases and as an autosomal dominant genetic disorder results from NF-1 gene mutation with 100% penetration and wide phenotypic variability. The disease can involve a wide variety of tissues derived from all three embryonic layers. NF-1 vasculopathy has been described primarily in peripheral arteries, but arteries supplying the CNS may also be involved. Of those, extracranial vertebral involvement is the commonest and most important. A series of four patients with NF-1 and vascular disease of the vertebral artery is described with a review of the pathophysiology, vascular phenotypes, their management and the pertinent literature.
authors.affiliation: Service de Neuroradiologie Diagnostique et Thérapeutique, Hôpital de Bicetre, Le Kremlin-Bicetre, Paris, France - Department of Neuroradiology, University of Sao Paulo, Brasil - vitormpbr@hotmail.com.
authors.forename: V M
authors.initials: VM
authors.lastname: Pereira
authors.forename: S
authors.initials: S
authors.lastname: Geiprasert
authors.forename: T
authors.initials: T
authors.lastname: Krings
authors.forename: J G M P
authors.initials: JG
authors.lastname: Caldas
authors.forename: F
authors.initials: F
authors.lastname: Toulgoat
authors.forename: A
authors.initials: A
authors.lastname: Ozanne
authors.forename: P
authors.initials: P
authors.lastname: Mercier
authors.forename: P L
authors.initials: PL
authors.lastname: Lasjaunias