A novel organogermanium protected atopic dermatitis induced by oxazolone.
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that is often associated with other atopic diseases, such as asthma and allergic rhinitis. Although topical steroids have widely been prescribed for patients with AD, skin abnormalities are frequently observed after prolonged steroid treatment. In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-gamma inducer. The Ge-Vit treatment decreased the basal TEWL and IgE production and attenuated the disruption of the skin barrier function in a murine model of chronic contact dermatitis. The histological examination further supported the anti-AD activities. These results suggested that Ge-Vit can be a useful drug candidate for treating atopic dermatitis.
Lim
Doo Hyeon
DH
Department of Chemistry, College of Natural Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
Li
Minghua
M
Seo
Jung-A
JA
Lim
Kyung-Min
KM
Ham
Seung Wook
SW
D000818:Animals; D003876:Dermatitis, Atopic / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005857:Germanium / Q000627:therapeutic use*; D051379:Mice; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010080:Oxazoles / Q000009:adverse effects*
D009942:Organometallic Compounds; D010080:Oxazoles; D005857:Germanium