Chromosome X aneuploidy in Brazilian schizophrenic patients.
The identification of cytogenetic abnormalities in schizophrenic patients may provide clues to the genes involved in this disease. For this reason, a chromosomal analysis of samples from 62 schizophrenics and 70 controls was performed with trypsin-Giemsa banding and fluorescence in situ hybridization of the X chromosome. A clonal pericentric inversion on chromosome 9 was detected in one male patient, and we also discovered mosaicism associated with X chromosome aneuploidy in female patients, primarily detected in schizophrenic and normal female controls over 40 years old. When compared with age-matched female controls, the frequency of X chromosome loss was not significantly different between schizophrenics and controls, except for the 40- to 49-year-old age group. Our findings suggest that the X chromosome loss seen in schizophrenic patients is inherent to the normal cellular aging process. However, our data also suggest that X chromosome gain may be correlated with schizophrenia in this Brazilian population.
de Moraes
Leopoldo Silva
LS
Biomedicine, Federal University of Piauí, 64202-020 Parnaíba, PI, Brazil.
Khayat
André Salim
AS
de Lima
Patrícia Danielle Lima
PD
Lima
Eleonidas Moura
EM
Pinto
Giovanny Rebouças
GR
Leal
Mariana Ferreira
MF
de Arruda Cardoso Smith
Marília
M
Burbano
Rommel Rodríguez
RR
D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics; D000782:Aneuploidy; D001938:Brazil; D002869:Chromosome Aberrations; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D012559:Schizophrenia / Q000235:genetics*