title: Computerized assessment of breast lesion malignancy using DCE-MRI robustness study on two independent clinical datasets from two manufacturers.
abstract: OBJECTIVE
  To conduct a preclinical evaluation of the robustness of our computerized system for breast lesion characterization on two breast magnetic resonance imaging (MRI) databases that were acquired using scanners from two different manufacturers.
  
  
  METHODS
  Two clinical breast MRI databases were acquired from a Siemens scanner and a GE scanner, which shared similar imaging protocols and retrospectively collected under an institutional review board-approved protocol. In our computerized analysis system, after a breast lesion is identified by the radiologist, the computer performs automatic lesion segmentation and feature extraction and outputs an estimated probability of malignancy. We used a Bayesian neural network with automatic relevance determination for joint feature selection and classification. To evaluate the robustness of our classification system, we first used Database 1 for feature selection and classifier training, and Database 2 to test the trained classifier. Then, we exchanged the two datasets and repeated the process. Area under the receiver operating characteristic curve (AUC) was used as a performance figure of merit in the task of distinguishing between malignant and benign lesions.
  
  
  RESULTS
  We obtained an AUC of 0.85 (approximate 95% confidence interval [CI] 0.79-0.91) for (a) feature selection and classifier training using Database 1 and testing on Database 2; and an AUC of 0.90 (approximate 95% CI 0.84-0.96) for (b) feature selection and classifier training using Database 2 and testing on Database 1. We failed to observe statistical significance for the difference AUC of 0.05 between the two database conditions (P = .24; 95% confidence interval -0.03, 0.1).
  
  
  CONCLUSIONS
  These results demonstrate the robustness of our computerized classification system in the task of distinguishing between malignant and benign breast lesions on dynamic contrast-enhanced (DCE) MRI images from two manufacturers. Our study showed the feasibility of developing a computerized classification system that is robust across different scanners.
authors.affiliation: Department of Radiology, The University of Chicago, IL 60637, USA.
authors.forename: Weijie
authors.initials: W
authors.lastname: Chen
authors.forename: Maryellen L
authors.initials: ML
authors.lastname: Giger
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Newstead
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bick
authors.forename: Sanaz A
authors.initials: SA
authors.lastname: Jansen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Lan
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity