Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.
An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo[3.2.1]octanoid scaffolds will be described.
Goodell
John R
JR
Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
McMullen
Jonathan P
JP
Zaborenko
Nikolay
N
Maloney
Jason R
JR
Ho
Chuan-Xing
CX
Jensen
Klavs F
KF
Porco
John A
JA
Beeler
Aaron B
AB
D001331:Automation; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D004867:Equipment Design; D007202:Indicators and Reagents / Q000737:chemistry; D007700:Kinetics; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D012997:Solvents / Q000737:chemistry; D013696:Temperature
D001643:Bridged Bicyclo Compounds; D007202:Indicators and Reagents; D012997:Solvents