title: [The endothelin system: its involvement in the cardiovascular system].
abstract: The endothelin (ET)-system is composed of three endothelins, two receptors and two enzymes. The study of this system presents a great interest to understand the cardiovascular physiopathology. The ET-system is involved in cardiac organogenesis, angiogenesis and vascular tone homeostasis. Its role in arterial pulmonary hypertension, arterial hypertension and atherosclerosis has been shown. The numerous ET-system's targets suggest that it could be involved in pathologies which bring together various cardiovascular disorders such as the obstructive sleep apnoea syndrome. Thus, the ET-system generates today a lively interest for experimental and clinical trials.
authors.affiliation: Laboratoire HP2, hypoxie et physiopathologies cardiovasculaires et respiratoires, EA-3745, Inserm ERI0017, France. elise.belaidi@recherche.univ-lyon1.fr
authors.forename: E
authors.initials: E
authors.lastname: Belaidi
authors.forename: D
authors.initials: D
authors.lastname: Godin-Ribuot
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D002986:Clinical Trials as Topic; D019332:Endothelin-1 / Q000627:therapeutic use; D016232:Endothelins / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D038081:Organogenesis; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy
chemical_list: D019332:Endothelin-1; D016232:Endothelins