title: Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006.
abstract: Appropriate antimicrobial treatment of shigellosis depends on identifying its changing resistance pattern over time. We evaluated 15,255 stool culture submitted from July 2001 to June 2006 to the Laboratory of Children Medical Center Hospital. Specimen culture, bacterial identification, and disk diffusion susceptibility testing were performed according to National Committee for Clinical Laboratory Standards guidelines. From 15,255 stool samples, 682 (4.5%) were positive for Shigella species. The most common species of Shigella were S. flexneri (48%) and S. sonnei (45%); other results were S. dysenteriae (5%) and S. boydii (2%). The rate of sensitivity to ceftriaxone (95%), ceftizoxime (94%), and nalidixic acid (84%) were among our isolates. Resistance to co-trimoxazole and ampicillin was 87% and 86%, respectively. S. flexneri was more multiresistant than other species (47.9%). Our isolates are overall most sensitive to ceftriaxone, ceftazidime, and nalidixic acid (> 84%). They were most resistant to co-trimoxazole and ampicillin (> 86%). Because resistance varies according to specific location, continuous local monitoring of resistance patterns is necessary for the appropriate selection of empirical antimicrobial therapy.
authors.affiliation: Pediatrics Infectious Diseases Research Center, Department of Pediatrics-Infectious Disease, Tehran University of Medical Sciences, No. 62 Gharib Street, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Pourakbari
authors.forename: Setareh
authors.initials: S
authors.lastname: Mamishi
authors.forename: Negar
authors.initials: N
authors.lastname: Mashoori
authors.forename: Nastaran
authors.initials: N
authors.lastname: Mahboobi
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Ashtiani
authors.forename: Shahla
authors.initials: S
authors.lastname: Afsharpaiman
authors.forename: Masomeh
authors.initials: M
authors.lastname: Abedini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D052978:Disk Diffusion Antimicrobial Tests; D004405:Dysentery, Bacillary / Q000382:microbiology; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007492:Iran; D012760:Shigella / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents