title: Serum acute phase proteins concentrations in dogs during experimentally short-term induced overweight. A preliminary study.
abstract: The purpose of the study was to analyse serum concentrations of four different positive acute phase proteins (APPs): C-reactive protein, haptoglobin, serum amyloid A and ceruloplasmin in a model of experimentally short-term developed obesity in Beagle dogs. All APPs were quantified by commercially available ELISA methods and C-reactive protein was also determined by a highly sensitive time-resolved fluorometric assay. There were no significant differences between APPs concentrations at the beginning and the end of the study in groups of dogs that increased their body condition scores. In addition, dogs with body condition scores of 4 and 5 did not shown significant differences for any of the acute phase proteins studied compared with control dogs of BCS of 3, with exception of a decrease in haptoglobin. It was concluded that overweight induced in the experimental conditions of this study does not produce a significant change in acute phase proteins.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: Silvia
authors.initials: S
authors.lastname: Martinez
authors.forename: Ana
authors.initials: A
authors.lastname: Gutierrez
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Ceron
authors.forename: Fernando
authors.initials: F
authors.lastname: Tecles
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000821:Animal Feed; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D004032:Diet / Q000662:veterinary; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D050177:Overweight / Q000378:metabolism / Q000662:veterinary*; D015430:Weight Gain
chemical_list: D000209:Acute-Phase Proteins; D002097:C-Reactive Protein