title: Investigation of the prevalence of antibodies against neurotropic polyomaviruses BK, JC and SV40 in sera from patients affected by multiple sclerosis.
abstract: Viral agents seem to be linked to multiple sclerosis (MS). This association is based on evidence of (1) early exposure to viruses and MS onset; (2) increased prevalence of MS disease in specific geographic regions; (3) likelihood of developing MS being more prevalent in high-risk areas; (4) altered immune responses to different viruses. In this study, sera from patients affected by MS and controls, represented by sera from patients with other neurologic diseases, both inflammatory and non-inflammatory, and from healthy donors, were investigated for the presence of antibodies against neurotropic polyomaviruses BKV, JCV and SV40 in their sera. Our study has indicated that the prevalence of BKV antibodies in sera from MS patients is higher than that detected in normal individuals, while levels of antibodies against BKV and JCV are lower in MS patients compared to those of normal subjects.
authors.affiliation: Inserm U618 Protéases et vectorisation pulmonaires, Tours, University François Rabelais, Tours, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Ribeiro
authors.forename: Maxime J
authors.initials: MJ
authors.lastname: Fleury
authors.forename: Enrico
authors.initials: E
authors.lastname: Granieri
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Castellazzi
authors.forename: Fernanda
authors.initials: F
authors.lastname: Martini
authors.forename: Elisa
authors.initials: E
authors.lastname: Mazzoni
authors.forename: Pierre
authors.initials: P
authors.lastname: Coursaget
authors.forename: Mauro
authors.initials: M
authors.lastname: Tognon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000032:analysis*; D001739:BK Virus / Q000276:immunology*; D002648:Child; D004279:DNA, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000276:immunology; D007558:Italy / Q000453:epidemiology; D007577:JC Virus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000276:immunology*; D013539:Simian virus 40 / Q000276:immunology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral