title: Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.
abstract: Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.
authors.affiliation: Department of Chemistry, Infectious Diseases Centre for Excellence in Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. reema.k.thalji@gsk.com
authors.forename: Reema K
authors.initials: RK
authors.lastname: Thalji
authors.forename: Nambi
authors.initials: N
authors.lastname: Aiyar
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Davenport
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Erhardt
authors.forename: Lorena A
authors.initials: LA
authors.lastname: Kallal
authors.forename: Dwight M
authors.initials: DM
authors.lastname: Morrow
authors.forename: Shobha
authors.initials: S
authors.lastname: Senadhi
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Burns-Kurtis
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Marino
mesh_terms: D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology; D015539:Platelet Activation / Q000187:drug effects; D058921:Purinergic P2Y Receptor Antagonists / Q000737:chemistry* / Q000494:pharmacology; D058472:Receptors, Purinergic P2Y1 / Q000378:metabolism*; D014508:Urea / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001572:Benzofurans; D058921:Purinergic P2Y Receptor Antagonists; D058472:Receptors, Purinergic P2Y1; D014508:Urea; C105430:benzofuran