title: Deciphering host resistance and pathogen virulence: the Arabidopsis/Pseudomonas interaction as a model.
abstract: SUMMARY The last decade has witnessed steady progress in deciphering the molecular basis of plant disease resistance and pathogen virulence. Although contributions have been made using many different plant and pathogen species, studies of the interactions between Arabidopsis thaliana and Pseudomonas syringae have yielded a particularly significant body of information. The present review focuses on recent findings regarding R gene products and the guard hypothesis, RAR1/SGT1 and other examples where protein processing activity is implicated in disease resistance or susceptibility, the use of microarray expression profiling to generate information and experimental leads, and important molecular- and genome-level discoveries regarding P. syringae effectors that mediate bacterial virulence. The development of the Arabidopsis-Pseudomonas model system is also reviewed briefly, and we close with a discussion of characteristics to consider when selecting other pathosystems as experimentally tractable models for future research.
authors.affiliation: Genomics and Biotecnology Program, Universidade Católica de Brasília, Brasília, DF, Brazil.
authors.forename: Betania F
authors.initials: BF
authors.lastname: Quirino
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Bent