Detection of SNP-SNP interactions in trios of parents with schizophrenic children.
Schizophrenia (SZ) is a heritable and complex psychiatric disorder with an estimated worldwide prevalence of about 1%. Research on the risk factors for SZ has thus far yielded few clues to causes, but has pointed to a heterogeneous etiology that likely involves multiple genes and gene-environment interactions. In this manuscript, we apply a novel method (trio logic regression, Li et al., 2009) to case-parent trio data from a SZ candidate gene study conducted on families of Ashkenazi Jewish descent, and demonstrate the method's ability to detect multi-gene models for SZ risk in the family-based design. In particular, we demonstrate how this method revealed a genotype-phenotype association that includes an allele without marginal effect.
Li
Qing
Q
Department of Biostatistics, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Fallin
M Daniele
MD
Louis
Thomas A
TA
Lasseter
Virginia K
VK
McGrath
John A
JA
Avramopoulos
Dimitri
D
Wolyniec
Paula S
PS
Valle
David
D
Liang
Kung-Yee
KY
Pulver
Ann E
AE
Ruczinski
Ingo
I
D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007585:Jews; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D010290:Parents; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*