title: Acral erythema with bullous formation: a side effect of chemotherapy in a child with acute lymphoblastic leukemia.
abstract: Chemotherapy-induced acral erythema (CIAE) with bullous formation is an uncommon complication in children. We describe herein a child who developed CIAE with bullous formation following high-dose methotrexate and cytarabine for relapsed acute lymphoblastic leukemia. The rash completely resolved within two weeks of the appearance without any specific treatment. CIAE may develop in children with hematological malignancies as a complication of pediatric chemotherapeutic regimens, and pediatricians should be aware of this phenomenon despite its rarity.
authors.affiliation: Department of Pediatric Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Selin
authors.initials: S
authors.lastname: Aytaç
authors.forename: Fatma
authors.initials: F
authors.lastname: Gümrük
authors.forename: Mualla
authors.initials: M
authors.lastname: Cetin
authors.forename: Murat
authors.initials: M
authors.lastname: Tuncer
authors.forename: Sevgi
authors.initials: S
authors.lastname: Yetgin
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001768:Blister / Q000139:chemically induced*; D002648:Child; D003561:Cytarabine / Q000009:adverse effects*; D004890:Erythema / Q000139:chemically induced*; D005533:Foot Dermatoses / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D008727:Methotrexate