title: The role of Nicorandil in non-healing surgical wounds.
abstract: We report two patients with non-healing surgical wounds, which healed after the withdrawal of Nicorandil therapy. Nicorandil should be recognised as an aetiological factor for non-healing wounds or ulcers once other inflammatory and malignant causes have been excluded. This may avoid surgery for high-risk patients and may also reduce complications for patients who undergo surgery for non-healing wounds. As Nicorandil is used in patients with severe coronary artery disease, it is recommended that the advice of a cardiologist is sought prior to cessation or adjustment to its dose.
authors.affiliation: Department of General Surgery, Royal Free Hospital, London, UK. adriddell@hotmail.com
authors.forename: A D
authors.initials: AD
authors.lastname: Riddell
authors.forename: U
authors.initials: U
authors.lastname: Minhas
authors.forename: G L
authors.initials: GL
authors.lastname: Williams
authors.forename: K J
authors.initials: KJ
authors.lastname: Harding
mesh_terms: D000369:Aged, 80 and over; D003125:Colostomy; D005260:Female; D006484:Hemorrhoids / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D020108:Nicorandil / Q000009:adverse effects / Q000494:pharmacology*; D011183:Postoperative Complications / Q000139:chemically induced*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil