Monastrol analogs: a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening.
A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via Hantzsch- and Biginelli-like condensations has been developed. The ability of these compounds to inhibit Eg5 activity has been examined. The results indicate that synthetic manipulations in the monastrol thiourea moiety are inefficient.
Svetlik
Jan
J
Department of Pharmaceutical Analysis and Nuclear Pharmacy, Comenius University, Odbojarov 10, SK-832 32 Bratislava, Slovak Republic. svetlik@fpharm.uniba.sk
Veizerová
Lucia
L
Mayer
Thomas U
TU
Catarinella
Mario
M
D010100:Oxygen / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013871:Thiones / Q000737:chemistry*
D011743:Pyrimidines; D013871:Thiones; C400223:monastrol; D010100:Oxygen