Aging and HIV infection: a comparison between older HIV-infected persons and the general population.
BACKGROUND
As HIV-infected persons age, the relative contribution of HIV infection, combination antiretroviral therapy (cART), and the normal aging process to the frequent comorbidities is unknown.


METHODS
We prospectively evaluated comorbidities, cardiovascular risk, cognitive function, and anthropomorphic and laboratory parameters of HIV-infected persons aged 50 years and over in two US urban clinics. Results were compared to controls from the National Health and Nutrition Examination Survey (NHANES) matched 1:1 by age, race, gender, smoking status, and body mass index (BMI).


RESULTS
We enrolled 122 HIV-infected persons; median age 55 years, 83% male, 57% Caucasian, 39% current smokers, mean BMI 26 kg/m2, and 92% on cART. Compared to controls, HIV-infected persons had a higher prevalence of hypertension (54% vs 38%), hypertriglyceridemia (51% vs 33%), low bone mineral density (BMD) (39% vs 0%), and lipodystrophy and greater receipt of antihypertensive and lipid-lowering medications (all Ps < .05). Groups were similar in prevalence of coronary heart disease, diabetes mellitus, chronic viral hepatitis, non-AIDS-defining malignancies and Framingham Risk and cognitive function scores.


CONCLUSIONS
Older HIV-infected persons have a higher prevalence of hypertension, hypertriglyceridemia, low BMD, and lipodystrophy than matched controls, suggesting that HIV and treatment-related factors exceed "normal" aging in the development of those problems.
Onen
Nur F
NF
Washington University, School of Medicine, St. Louis, Missouri 63110, USA. nonen@dom.wustl.edu
Overton
E Turner
ET
Seyfried
Warren
W
Stumm
Emily R
ER
Snell
Mariea
M
Mondy
Kristin
K
Tebas
Pablo
P
D000368:Aged; D000375:Aging; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000453:epidemiology; D008060:Lipodystrophy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008923:Missouri / Q000453:epidemiology; D009749:Nutrition Surveys; D010045:Outpatients; D010414:Pennsylvania / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors
D019380:Anti-HIV Agents