title: Skin coverage in frostbite injuries: experimental study.
abstract: OBJECTIVE
  Dermal grafting after secondary wound healing constitutes the mainstay of management in cold injury tissue defects, displacing the use of local flaps. We present an experimental study in which the following treatments for frostbite defects are compared: guided wound healing, partial-thickness skin grafts and cutaneous flaps, which by definition posses an independent vascular supply.
  
  
  METHODS
  A dorsal defect in the rabbit leg was created using a cold injury model. The animals were separated in three different sets, each with a specific treatment for the defect. In the first group, the defect was left to heal by secondary intention. In the second group, a dermal graft was used. In the third group, the defect was covered with a flap. The surface area lacking cutaneous cover at day 7 (SCp7) and the healing time (TC) were analysed.
  
  
  RESULTS
  The cases in which flaps were employed presented a SCp7 of 62mm2, and a healing time of 11.6 days. When grafts were used, the SCp7 was 130mm2, and the healing time 15.9 days. The group which healed by secondary intention presented a SCp7 of 225mm2 and a healing time of 20.1 days.
  
  
  CONCLUSIONS
  Compared to grafts, flaps provide a better skin cover both in quality and quantity. Their own vascularity makes them nondependent of the characteristics of the recipient bed. Due to this and to the radioisotopic and resonance imaging studies, which determine the ultimate level of tissue damage demarcation in a few days, an early treatment for these injuries is possible, with no need to achieve a favourable recipient site.
authors.affiliation: Mixed Research Unit, University of Zaragoza, Spain; Department of Plastic Surgery, Miguel Servet University Hospital of Zaragoza, Spain. juldelgado@yahoo.com
authors.forename: Julio
authors.initials: J
authors.lastname: Delgado-Martínez
authors.forename: Gregorio
authors.initials: G
authors.lastname: Martínez-Villén
authors.forename: Jose R
authors.initials: JR
authors.lastname: Morandeira
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Velasco
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005627:Frostbite / Q000601:surgery*; D016014:Linear Models; D011817:Rabbits; D016038:Skin Transplantation / Q000379:methods*; D013524:Surgical Flaps; D014945:Wound Healing