Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens.
Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular system. This study was designed to evaluate the antiarrhythmic effects as well as the electrophysiological properties of oxymatrine. The antiarrhythmic activity of oxymatrine was observed in a rat model of arrhythmia induced by coronary ligation. Action potential duration (APD), L-type calcium current (I(Ca-L) ), transient outward potassium current (I(to) ) and inward rectifier potassium current (I(K1)) in rat ventricular myocytes were recorded by utilizing the whole cell patch-clamp technique. The results showed that administration of oxymatrine significantly delayed the onset of ventricular arrhythmia, decreased the duration of ventricular arrhythmia and reduced the arrhythmia score of arrhythmic rats. The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of I(Ca-L) , enhancement of I(to) and inhibition of I(K1).
Cao
Yong-gang
YG
Department of Pharmacology, Daqing Campus of Harbin Medical University, Daqing, 163319, P. R. China.
Jing
Shan
S
Li
Lei
L
Gao
Jing-quan
JQ
Shen
Zhi-ying
ZY
Liu
Yan
Y
Xing
Yan
Y
Wu
Ming-li
ML
Wang
Ye
Y
Xu
Chang-qing
CQ
Sun
Hong-li
HL
D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D020746:Calcium Channels, L-Type / Q000187:drug effects; D022062:Electrophysiologic Techniques, Cardiac; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D024661:Potassium Channels, Inwardly Rectifying / Q000187:drug effects; D011807:Quinolizines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029909:Sophora / Q000737:chemistry*; D000093842:Matrines
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D020746:Calcium Channels, L-Type; D024661:Potassium Channels, Inwardly Rectifying; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines