[The pathological characteristics and clinical significances of maturational change of port-wine stain].
OBJECTIVE
In this study histologic observations were presented to elucidate the possible mechanism of maturational change of port-wine stain(PWS).


METHODS
Normal PWS(3 cases) , thicken PWS (11 cases) and nodular PWS (9 cases) were included to present histologic observations.


RESULTS
Normal PWS, only shows mild dilated, thin-walled vessels within superficial dermis. Thicken PWS, shows further dilated vessels and sebaceous gland throughout dermis and superficial subcutaneous fat. Nodular PWS can be divided into three groups. I Similar to thicken PWS, shows further dilated vessels and sebaceous gland throughout dermis and superficial subcutaneous fat. II Shows Large number of dilated vessels, honeycombing and less vascular mesenchymal. III Tenacious texture shows mild dilated vessels, diffused collagen, mesenchymal rarefaction, lymphocyte infiltration and lymphedema change.


CONCLUSIONS
Histologic examination revealed not only the expected vascular abnormalities, but also a number of widely distributed hamartomatous changes in thicken and nodular PWS. The complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of PWS.
Wang
Wei
W
Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiaotong University, Shanghai 200011, China. docwang001@gmail.com
Lin
Xiao-xi
XX
Ma
Gang
G
Li
Wei
W
Hu
Xiao-jie
XJ
Jin
Yun-bo
YB
Chen
Hui
H
Yang
Chuan
C
Wang
Wei
W
D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019339:Port-Wine Stain / Q000473:pathology*; D055815:Young Adult