title: Lack of association between risk of biliary tract cancer and circulating IGF (Insulin-like Growth Factor) -I, IGF-II or IGFBP-3 (IGF-binding Protein-3): A nested case-control study in a large scale cohort study in Japan.
abstract: Biliary tract cancer, encompassing gallbladder and bile duct cancers, has a poor prognosis, but little is known of the etiology. A nested case-control study was here conducted to evaluate the association between serum levels of IGF-I, IGF-II and IGFBP-3 and death from biliary tract cancer. In a large scale cohort study, 35 gallbladder and 42 bile duct cancers were observed during the follow-up. For each subject in the case group, 1-3 control subjects (228 in total) were selected randomly, matched for sex, age (as near as possible) and residential area. The subjects were divided into tertiles by circulating levels of IGF-I, IGF-II or IGFBP-3. Using conditional logistic regression, risks among the tertiles were compared adjusted for defecation, smoking and drinking habits. No remarkable differences in risks of gallbladder or bile duct cancer were observed among tertiles of IGF-I or IGF-II, and no remarkable trend was observed. Circulating IGFBP-3 showed an inverse U-shape association with gallbladder cancer and a U-shaped one with bile duct cancer. Associations between IGF-I or IGF-II and gallbladder or bile duct cancer thus were lacking or very weak. The observed U- and inverse U-shaped association of IGFBP-3 with the cancers is not suggestive of any meaningful relationships.
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Japan. kikuchis@aichi-med-u.ac.jp
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yagyu
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Teruo
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Obata
authors.forename: Michiko
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
authors.forename: Kei
authors.initials: K
authors.lastname: Nakachi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000328:Adult; D000368:Aged; D001661:Biliary Tract Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II