title: A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation.
abstract: Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jae-Jeong
authors.initials: JJ
authors.lastname: Park
authors.forename: Sook Jung
authors.initials: SJ
authors.lastname: Yun
authors.forename: Jee-Bum
authors.initials: JB
authors.lastname: Lee
authors.forename: Seong-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Won
authors.forename: Seung-Chul
authors.initials: SC
authors.lastname: Lee