[Expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps].
OBJECTIVE
To investigate the expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps.


METHODS
Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining were used to detect the expressions of LL-37 and IL-8 in nasal polyp tissues of 31 patients with chronic sinusitis and inferior turbinate tissues of 11 patients with chronic rhinitis.


RESULTS
LL-37 and IL-8 mRNA were all positively expressed in all nasal polyps and inferior turbinate tissues. There were significant increases of LL-37 and IL-8 mRNA expressions in nasal polyps compared with the inferior turbinate tissues (P < 0.01). There were also significant increases of positive expression rates of LL-37 and IL-8 protein in nasal polyps, compared with the inferior turbinate tissues (P < 0.01). There was a positive relationship between the mRNA and protein expressions of LL37 and IL-8 (P < 0.01).


CONCLUSIONS
The expressions of LL-37 and IL-8 in nasal polyps suggest that they may play a role in the pathogenesis of chronic sinusitis. Besides its innate immune, LL-37 could enhance human body's anti-infected function by increasing acquired immune.
Xie
Dan
D
Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Guo
Yunkai
Y
Wu
Dan
D
Xie
Dinghua
D
D000328:Adult; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D009298:Nasal Polyps / Q000378:metabolism*; D012852:Sinusitis / Q000378:metabolism*; D055815:Young Adult
D023181:Antimicrobial Cationic Peptides; C508606:CXCL8 protein, human; D054804:Cathelicidins; D016209:Interleukin-8