Intestinal schistosomiasis caused by both Schistosoma intercalatum and Schistosoma mansoni.
A case is presented of intestinal schistosomiasis due to both Schistosoma intercalatum and Schistosoma mansoni in a 30-year-old man from Senegal with discussion of diagnostic approach, species identification and determination of the effect of treatment. The patient was admitted to hospital for investigation of renal failure, arterial hypertension and hypereosinophilia. Repeated stool examinations for ova and parasites were negative. Ultrasonography (US) and computed tomography (CT) of the abdomen showed no abnormalities. US of the urinary tract showed kidneys of borderline size with increased echogenicity. Cystoscopy and histopathological examination of bladder biopsy specimens were normal. Flexible colonoscopy revealed numerous nodular lesions in the rectosigmoid region and a few similar lesions in the transverse colon, the histopathological examination of which showed deposition of Schistosoma ova with granuloma formation. Examination of multiple crush biopsy specimens from the rectosigmoid region revealed numerous granulomas formed around Schistosoma eggs which had a terminal spine and were identified as S. intercalatum (longer than Schistosoma haematobium and with a slightly curved terminal spine) and a very few S. mansoni eggs. Crush biopsies from the lesions in the transverse colon showed only S. mansoni eggs. In conclusion, the examination of multiple crush biopsy specimens is a very sensitive and specific technique for species identification of Schistosoma, especially in mixed infections, and for defining the location and extent of the granulomas evoked by each species.
Tzanetou
Konstantina
K
Microbiology Department, General Hospital of Athens G. Gennimatas, Athens, Greece. alina.serafin@ucl.ac.uk
Astriti
Myrto
M
Delis
Vassilios
V
Moustakas
George
G
Choreftaki
Theodosia
T
Papaliodi
Eugenia
E
Sarri
Katerina
K
Adamis
George
G
D000328:Adult; D017311:Amlodipine / Q000627:therapeutic use; D000818:Animals; D001713:Biphenyl Compounds / Q000627:therapeutic use; D012809:Colon, Sigmoid / Q000469:parasitology / Q000473:pathology; D044684:Colon, Transverse / Q000469:parasitology / Q000473:pathology; D003113:Colonoscopy; D006651:Histocytochemistry; D006801:Humans; D000077405:Irbesartan; D008018:Life Cycle Stages; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use; D012547:Schistosoma / Q000302:isolation & purification*; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D013777:Tetrazoles / Q000627:therapeutic use
D001713:Biphenyl Compounds; D013777:Tetrazoles; D017311:Amlodipine; D011223:Praziquantel; D000077405:Irbesartan