Investigation and comparison of colon specificity of novel polymer khaya gum with guar gum.
To investigate the colon specificity of novel natural polymer khaya gum and compare with guar gum. Release profile of tablets was carried out in presence and absence of rat cecal contents. The fast disintegrating core tablets of budesonide, were initially prepared by direct compression technique. Later, these tablets were coated with khaya gum or guar gum. After suitable pre compression and post compression evaluation, these tablets were further coated using Eudragit L-100 by dip coating technique. X-ray images were taken to investigate the movement, location and the integrity of the tablets in different parts of gastro intestinal tract in rabbits. The release profiles revealed that khaya gum or guar gum, when used as compression coating, protected the drug from being released in the upper parts of the gastro intestinal tract to some extent but the enteric coated formulations completely protected the drug from being released in the upper parts of the gastro intestinal tract, and released the drug in the colon by bacterial degradation of gums. It was found that both the polysaccharide polymers exhibited different release profiles in presence and absence of rat cecal contents. However, further enteric coat helped in targeting the drug to colon very effectively. Better dissolution models revealed the colon specificity of polysaccharides and alone can not be used either for targeting the drug to the colon or for sustaining or controlling the release of drug.
Prabhu
Prabhakara
P
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, Karnataka, India. prabhuprashu@rediffmail.com
Ahamed
Nissara
N
Matapady
Harish Nairy
HN
Ahmed
Mohd Gulzar
MG
Narayanacharyulu
R
R
Satyanarayana
D
D
Subrahmanayam
Evs
E
D000818:Animals; D019819:Budesonide / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003106:Colon / Q000378:metabolism*; D004337:Drug Carriers; D005685:Galactans / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008351:Mannans / Q000008:administration & dosage*; D029582:Meliaceae; D009928:Organ Specificity; D053149:Plant Gums / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats; D012995:Solubility; D013607:Tablets
D004337:Drug Carriers; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011108:Polymers; D013607:Tablets; D019819:Budesonide; C007894:guar gum