title: Properties of the human cone system electroretinogram during light adaptation.
abstract: Changes in the response characteristics of the flash electroretinogram (ERG) of the human cone system were studied during the time course of adaptation to a cone-isolating ganzfeld background. During light adaptation, the amplitudes of the b- and i-waves increased, while the implicit time of the b-wave decreased. The amplitude of the a-wave and the implicit times of the a- and i-waves did not change systematically during light adaptation. Luminance-response functions for b-wave amplitude were obtained at discrete times following background onset and were analyzed using the hyperbolic equation R/R(max) = L(n)/(L(n) + K(n)). The increase in b-wave amplitude was characterized by increases in R(max), K, and n. The decrease in b-wave implicit time was of a similar magnitude at all flash luminances. The amplitude increase of the i-wave only occurred at moderate flash luminances. The results provide a basis for optimizing the clinical recording of cone-isolated single-flash ERGs.
authors.forename: N S
authors.initials: NS
authors.lastname: Peachey
authors.forename: K R
authors.initials: KR
authors.lastname: Alexander
authors.forename: G A
authors.initials: GA
authors.lastname: Fishman
authors.forename: D J
authors.initials: DJ
authors.lastname: Derlacki