title: Sustained response following sorafenib therapy in an older adult patient with advanced renal cancer on hemodialysis: a case report.
abstract: The prognosis for patients with renal cell carcinoma is very poor, with a five-year survival rate of less than 10%. Sorafenib is an orally administered multikinase inhibitor that blocks intracellular kinases in the Raf/MEK/ERK pathway involved in tumor proliferation, and also kinases responsible for angiogenesis, including VEGFr-2, VEGFr-3, Flt-3, PDGFr-β and c-KIT. As a consequence of its limited renal clearance, sorafenib appears to be suitable for patients with advanced kidney cancer and terminal renal failure. The case of a 72-year-old male patient on hemodialysis and receiving sorafenib treatment for mRCC is reported.
authors.affiliation: Department of Oncology, San Giacomo Hospital Novi Ligure, Alessandria, Italy. bruno.castagneto@gmail.com
authors.forename: B
authors.initials: B
authors.lastname: Castagneto
authors.forename: I
authors.initials: I
authors.lastname: Stevani
authors.forename: L
authors.initials: L
authors.lastname: Giorcelli
authors.forename: F
authors.initials: F
authors.lastname: Montefiore
authors.forename: G L
authors.initials: GL
authors.lastname: Bigatti
authors.forename: P
authors.initials: P
authors.lastname: Pisacco
authors.forename: M F
authors.initials: MF
authors.lastname: Cosimi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000473:pathology; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D011725:Pyridines / Q000627:therapeutic use*; D006435:Renal Dialysis; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib