title: A multiple imputation approach to disclosure limitation for high-age individuals in longitudinal studies.
abstract: Disclosure limitation is an important consideration in the release of public use data sets. It is particularly challenging for longitudinal data sets, since information about an individual accumulates with repeated measures over time. Research on disclosure limitation methods for longitudinal data has been very limited. We consider here problems created by high ages in cohort studies. Because of the risk of disclosure, ages of very old respondents can often not be released; in particular, this is a specific stipulation of the Health Insurance Portability and Accountability Act (HIPAA) for the release of health data for individuals. Top-coding of individuals beyond a certain age is a standard way of dealing with this issue, and it may be adequate for cross-sectional data, when a modest number of cases are affected. However, this approach leads to serious loss of information in longitudinal studies when individuals have been followed for many years. We propose and evaluate an alternative to top-coding for this situation based on multiple imputation (MI). This MI method is applied to a survival analysis of simulated data, and data from the Charleston Heart Study (CHS), and is shown to work well in preserving the relationship between hazard and covariates.
authors.affiliation: Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, PA 19454, USA. di_an@merck.com
authors.forename: Di
authors.initials: D
authors.lastname: An
authors.forename: Roderick J A
authors.initials: RJ
authors.lastname: Little
authors.forename: James W
authors.initials: JW
authors.lastname: McNally
mesh_terms: D000367:Age Factors; D015331:Cohort Studies; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D030881:Disclosure; D005260:Female; D006331:Heart Diseases; D006801:Humans; D008137:Longitudinal Studies; D008297:Male