title: Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: Case-control studies generally suggesting an inverse association between sun exposure and non-Hodgkin lymphoma (NHL) have led to speculation that vitamin D may protect against lymphomagenesis. To examine this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D (25(OH)D) and subsequent NHL risk within 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. The authors analyzed measurements from 1,353 cases and 1,778 controls using conditional logistic regression and other methods to estimate the association of 25(OH)D with NHL. No clear evidence of association between categories of 25(OH)D concentration and NHL was observed overall (P(trend) = 0.68) or by sex (men, P(trend) = 0.50; women, P(trend) = 0.16). Findings for other measures (continuous log(25(OH)D), categories of 25(OH)D using sex-/cohort-/season-specific quartiles as cutpoints, categories of season-adjusted residuals of predicted 25(OH)D using quartiles as cutpoints) were generally null, although some measures of increasing 25(OH)D were suggestive of an increased risk for women. Results from stratified analyses and investigations of histologic subtypes of NHL were also null. These findings do not support the hypothesis that elevated circulating 25(OH)D concentration is associated with a reduced risk of NHL. Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects.
authors.affiliation: National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: D Michal
authors.initials: DM
authors.lastname: Freedman
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gapstur
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.forename: Francine
authors.initials: F
authors.lastname: Laden
authors.forename: Unhee
authors.initials: U
authors.lastname: Lim
authors.forename: Gertraud
authors.initials: G
authors.lastname: Maskarinec
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Stevens
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Kimberly
authors.initials: K
authors.lastname: Bertrand
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Lonn
authors.initials: L
authors.lastname: Irish
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Judith
authors.initials: J
authors.lastname: Hoffman-Bolton
authors.forename: Edward L
authors.initials: EL
authors.lastname: Giovannucci
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Walter
authors.initials: W
authors.lastname: Willett
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000517:prevention & control*; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012621:Seasons; D013472:Sunlight; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D014807:Vitamin D