title: Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure.
abstract: A novel bridged nucleic acid bearing cyclic urea structure was successfully synthesized and introduced into oligonucleotide, displaying attractive characteristics of highly RNA selective hybridization ability and excellent resistance towards nuclease degradation.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Nishida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Baba
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kodama
authors.forename: Aiko
authors.initials: A
authors.lastname: Yahara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
mesh_terms: D000818:Animals; D017839:Crotalus / Q000378:metabolism*; D003500:Cyclization; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D012313:RNA / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D009841:Oligonucleotides; D012313:RNA; D014508:Urea; D010727:Phosphoric Diester Hydrolases