Phylogenetic analysis and subtyping of acute and fulminant strains of hepatitis E virus isolates of North India with reference to disease severity.
Hepatitis E is endemic to the Indian subcontinent, with a seroprevalence of 4-20%, and more than 25% of acute viral hepatitis is due to HEV. The northern parts of India have been experiencing outbreaks and sporadic cases of HEV since 1955. In a total of sixteen HEV sequences, ten acute viral hepatitis and 6 fulminant hepatic failure cases were analysed. Subtypes 1a and 1c of HEV are prevalent in North India, with the subtype-1c showing a trend towards fulminancy.
Pujhari
Sujit Kumar
SK
Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. sujitpujhari@gmail.com
Kumar
Subrat
S
Ratho
Radha Kanta
RK
Chawla
Yogesh Kumar
YK
Chakraborti
Anuradha
A
D000208:Acute Disease / Q000453:epidemiology; D016751:Hepatitis E / Q000453:epidemiology / Q000821:virology*; D016752:Hepatitis E virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007194:India / Q000453:epidemiology; D017114:Liver Failure, Acute / Q000453:epidemiology / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012720:Severity of Illness Index