title: Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates.
abstract: Despite intense study in mammals, the different roles played by the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia, and perhaps in metastasis are not fully understood. In this review, I will present evidence of neoplasia and invasive malignancy, as well as tumor immunity in invertebrates and nonmammalian vertebrates. I will also present a comparative and evolutionary view of the complex interactions between neoplasia and the host immune system. Overall, I wish to go beyond the too simplistic dichotomy between invertebrates with innate immunity that are only affected with benign neoplasia and vertebrates with adaptive immunity that are affected by metastatic malignancies or cancer.
authors.affiliation: Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, United States. jacques robert@urmc.rochester.edu
authors.forename: Jacques
authors.initials: J
authors.lastname: Robert
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002471:Cell Transformation, Neoplastic; D019143:Evolution, Molecular; D007113:Immunity, Innate; D007157:Immunologic Surveillance; D007448:Invertebrates / Q000276:immunology*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D010828:Physiology, Comparative; D019139:Tumor Escape; D014714:Vertebrates / Q000276:immunology*