Effect of bone block graft with rhBMP-2 on vertical bone augmentation.
The effectiveness of vertical bone augmentation was evaluated in the cranial bone of 15 rabbits using a block of deproteinized bovine bone plus 10% porcine collagen (DBBB) and a cortico-cancellous human bone block (CHBB) with recombinant human bone morphogenetic protein-2 (rhBMP-2) in comparison with a guided bone regeneration (GBR) technique. The rabbits were divided into six groups: DBBB alone, DBBB/rhBMP-2, DBBB/membrane, CHBB alone, CHBB/rhBMP-2 and CHBB/membrane groups. After 12 weeks, the rabbits were killed. The CHBB groups showed higher values than the DBBB groups in terms of vertical height, the area of new bone fill and the maintained grafted area. In the CHBB groups, the CHBB/rhBMP-2 group revealed similar results to GBR. This animal study verifies that a CHBB with rhBMP-2 could be an alternative treatment option for vertical bone augmentation.
Kim
S-J
SJ
Department of Oral and Maxillofacial Surgery, Ewha Womans University, Seoul, South Korea.
Shin
H-S
HS
Shin
S-W
SW
D020341:Absorbable Implants; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000704:Analysis of Variance; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage; D003094:Collagen / Q000627:therapeutic use; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D011817:Rabbits; D011994:Recombinant Proteins; D013552:Swine; D014716:Vertical Dimension
C525718:BMP2 protein, human; C077540:Bio-Oss; D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D008903:Minerals; D011994:Recombinant Proteins; D003094:Collagen