title: Palladium-catalyzed allylation of aryl halides with homoallyl alcohols bearing a trisubstituted double bond: application to chirality transfer from hydroxylated carbon to benzylic one.
abstract: A facile route to homoallyl alcohols bearing a trisubstituted double bond has been devised. The palladium-catalyzed reactions of aryl halides with the alcohols thus synthesized result in regiospecific allyl transfer from the alcohols to aryl halides via retro-allylation, providing allylarenes having two substituents at the 1 and 2 positions of the allyl moiety. Optically active homoallyl alcohols transfer their chirality at the hydroxylated carbon to the benzylic carbon of the product.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Wakabayashi
authors.forename: Daishi
authors.initials: D
authors.lastname: Fujino
authors.forename: Sayuri
authors.initials: S
authors.lastname: Hayashi
authors.forename: Hideki
authors.initials: H
authors.lastname: Yorimitsu
authors.forename: Koichiro
authors.initials: K
authors.lastname: Oshima