Heart of newt: a recipe for regeneration.
The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart has limited regenerative capacity, previous studies have focused on cellular therapeutic strategies in an attempt to modulate cardiac regeneration. An alternative strategy relies on the modulation of endogenous stem/progenitor cells or signaling pathways to promote cardiac regeneration. Several organisms, including the newt, have an incomparable capacity for the regeneration of differentiated tissues. An enhanced understanding of the signals, pathways, and factors that mediate the regenerative response in these organisms may be useful in modulating the regenerative response of mammalian organs including the injured adult heart.
Singh
Bhairab N
BN
Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Koyano-Nakagawa
Naoko
N
Garry
John P
JP
Weaver
Cyprian V
CV
D000818:Animals; D005121:Extremities; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000628:therapy; D006801:Humans; D008679:Metaplasia; D012038:Regeneration / Q000235:genetics; D044968:Regenerative Medicine; D012455:Salamandridae; D015398:Signal Transduction; D033581:Stem Cell Transplantation