title: Oral administration of Lactobacillus salivarius inhibits the allergic airway response in mice.
abstract: Asthma is recognized throughout the world as a chronic airway inflammatory disease. In this study, we investigated the effect of probiotics in response to antigen challenge in an ovalbumin (OVA)-sensitized asthma model in BALB/c mice. Lactobacillus salivarius PM-A0006 was orally administered to mice before antigen challenge. After antigen challenge, serum OVA-specific antibody levels, airway responsiveness to methacholine, influx of inflammatory cells to the lung, and cytokine levels in bronchoalveolar lavage (BAL) fluid and splenocytes were assessed. Oral treatment with live L. salivarius PM-A0006 significantly attenuated the influx of eosinophils to the airway lumen and reduced the levels of serum OVA-specific IgE and eotaxin in BAL fluid of antigen-challenged animals. Furthermore, L. salivarius PM-A0006 also decreased allergen-induced airway hyperresponsiveness and elevated the levels of IFN-gamma. These results showed that oral treatment with L. salivarius PM-A0006 could have therapeutic potential in the treatment of allergic airway disease.
authors.affiliation: Institute of Athletics, National Taiwan Sport University, No. 16, Sec. 1, Shuan-Shih Road, Taichung 40404, Taiwan.
authors.forename: Chia-Yang
authors.initials: CY
authors.lastname: Li
authors.forename: Hung-Chih
authors.initials: HC
authors.lastname: Lin
authors.forename: Kai-Chung
authors.initials: KC
authors.lastname: Hsueh
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Wu
authors.forename: Shih-Hua
authors.initials: SH
authors.lastname: Fang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000382:microbiology*; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000382:microbiology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007778:Lactobacillus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin