Formation of a cyclic tetrapeptide mimic by thermal azide-alkyne 1,3-dipolar cycloaddition.
Cyclodimerisation of an appropriate alpha,omega-difunctionalised precursor via thermal azide-alkyne 1,3-dipolar cycloaddition affords a cyclic pseudotetrapeptide whose conformation closely resembles that of a previously prepared analogue containing L-proline and 6-aminopicolinic acid subunits.
Krause
Martin R
MR
Technische Universität Kaiserslautern, Fachbereich Chemie-Organische Chemie, Erwin-Schrödinger-Strasse, D-67663 Kaiserslautern, Germany.
Goddard
Richard
R
Kubik
Stefan
S
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*; D013696:Temperature
D000480:Alkynes; D001386:Azides; D010456:Peptides, Cyclic