title: Orbitofrontal volume reductions during emotion recognition in patients with major depression.
abstract: BACKGROUND
  Major depressive disorder is associated with both structural and functional alterations in the emotion regulation network of the central nervous system. The relation between structural and functional changes is largely unknown. Therefore, we sought to determine the relation between structural differences and functional alterations during the recognition of emotional facial expressions.
  
  
  METHODS
  We examined 13 medication-free patients with major depression and 15 healthy controls by use of structural T1-weighted high-resolution magnetic resonance imaging (MRI) and functional MRI during 1 session. We set the statistical threshold for the analysis of imaging data to p < 0.001 (uncorrected).
  
  
  RESULTS
  As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. Additionally, depressed patients showed increased activity during emotion recognition in the middle frontal cortex, caudate nucleus, precuneus and lingual gyrus. Within this cerebral network, the orbitofrontal volumes were negatively correlated in depressed patients but not in healthy controls with changes in blood oxygen level-dependent signal in the middle frontal gyrus, caudate nucleus, precuneus and supplementary motor area.
  
  
  CONCLUSIONS
  Our results are limited by the relatively small sample size.
  
  
  CONCLUSIONS
  This combined functional and structural MRI study provides evidence that the orbitofrontal cortex is a key area in major depression and that structural changes result in functional alterations within the emotional circuit. Whether these alterations in the orbitofrontal cortex are also related to persistent emotional dysfunction in remitted mental states and, therefore, are related to the risk of depression needs further exploration.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians-University Munich, Germany. johanna.scheuerecker@med.uni-muenchen.de
authors.forename: Johanna
authors.initials: J
authors.lastname: Scheuerecker
authors.forename: Eva M
authors.initials: EM
authors.lastname: Meisenzahl
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Koutsouleris
authors.forename: Martin
authors.initials: M
authors.lastname: Roesner
authors.forename: Veronika
authors.initials: V
authors.lastname: Schöpf
authors.forename: Jennifer
authors.initials: J
authors.lastname: Linn
authors.forename: Martin
authors.initials: M
authors.lastname: Wiesmann
authors.forename: Hartmut
authors.initials: H
authors.lastname: Brückmann
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
authors.forename: Thomas
authors.initials: T
authors.lastname: Frodl
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology*