Testing the hormetic nature of homeopathic interventions through stress response pathways.
The scientific foundations of hormesis are now well established and include various biochemical and molecular criteria for testing the hormetic nature of chemicals and other modulators. In order to claim homeopathy as being hormetic, it is essential that, in addition to the hormetic biphasic dose response, homeopathic remedies should fulfill one or more molecular criteria. Since stress response pathways, such as heat shock response, antioxidative response, autophagic response and unfolded protein response, are integral components of the physiological hormesis, it is important that homeopathic drugs be tested for these pathways if these are to be considered as hormetins and to cause hormesis.
Rattan
Suresh I S
SI
Laboratory of Cellular Ageing, Department of Molecular Biology, Aarhus University, Aarhus, Denmark. rattan@mb.au.dk
Deva
Taru
T
D000222:Adaptation, Physiological / Q000187:drug effects*; D031204:Caloric Restriction; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy / Q000379:methods; D006705:Homeopathy / Q000379:methods*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D010600:Pharmacology / Q000379:methods; D040081:Protein Array Analysis; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013312:Stress, Physiological / Q000187:drug effects* / Q000502:physiology; D014116:Toxicology / Q000379:methods; D015262:Xenobiotics / Q000494:pharmacology
D015262:Xenobiotics