Ubiquitin recognition by the Cockayne syndrome group B protein: binding will set you free.
Transcription-coupled nucleotide excision repair (TC-NER) requires the coordinated efforts of many proteins. In this issue of Molecular Cell, Anindya et al. (2010) show that the proteins assemble at the site of DNA damage but cannot begin repair until the Cockayne syndrome group B protein (CSB) binds ubiquitin.
Gray
Lucas T
LT
Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195-7350, USA.
Weiner
Alan M
AM