A patient with lichen sclerosus, Langerhans cell histiocytosis, and invasive squamous cell carcinoma of the vulva.
We report a patient with vulvar lichen sclerosus, Langerhans cell histiocytosis (LCH), and later vulvar cancer. In LCH, high amounts of non functional Langerhans cells are present in the affected tissue, making it possible that LCH may have contributed to vulvar cancer development in this patient.
Simons
Michiel
M
Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, The Netherlands.
Van De Nieuwenhof
Hedwig P
HP
Van Der Avoort
Irene A M
IA
Bulten
Johan
J
De Hullu
Joanne A
JA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D007724:Vulvar Lichen Sclerosus / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy
D000305:Adrenal Cortex Hormones