SWItching on the transcriptional circuitry in melanoma.
Melanoma is an aggressive malignancy that is resistant to current therapy, and the most lethal of all human skin cancers. It is characterized by several genetic alterations that lead to changes in gene expression and tumorigenesis by triggering alterations in the normal transcriptional circuitry. Transformation and tumor progression are thought to be promoted by a complex interplay between the accumulation of genetic alterations and epigenetic changes. In this review, we discuss recent studies that have implicated SWI/SNF chromatin remodeling enzymes as epigenetic regulators of a transcriptional circuit that operates within the context the genetic alterations that frequently occur in melanoma.
Vinod Saladi
Srinivas
S
Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, OH, USA.
Marathe
Himangi
H
de la Serna
Ivana L
IL
D042002:Chromatin Assembly and Disassembly / Q000235:genetics* / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D008954:Models, Biological; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015533:Transcriptional Activation / Q000235:genetics* / Q000502:physiology
D002868:Chromosomal Proteins, Non-Histone; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors