title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
abstract: BACKGROUND
  Human height is considered highly heritable and correlated with certain disorders, such as type 2 diabetes and cancer. Despite environmental influences, genetic factors are known to play an important role in stature determination. A number of genetic determinants of adult height have already been established through genome wide association studies.
  
  
  METHODS
  To examine 51 single nucleotide polymorphisms (SNPs) corresponding to the 46 previously reported genomic loci for height in 8,184 European American children with height measurements. We leveraged genotyping data from our ongoing GWA study of height variation in children in order to query the 51 SNPs in this pediatric cohort.
  
  
  RESULTS
  Sixteen of these SNPs yielded at least nominally significant association to height, representing fifteen different loci including EFEMP1-PNPT1, GPR126, C6orf173, SPAG17, Histone class 1, HLA class III and GDF5-UQCC. Other loci revealed no evidence for association, including HMGA1 and HMGA2. For the 16 associated variants, the genotype score explained 1.64% of the total variation for height z-score.
  
  
  CONCLUSIONS
  Among 46 loci that have been reported to associate with adult height to date, at least 15 also contribute to the determination of height in childhood.
authors.affiliation: Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Mingyao
authors.initials: M
authors.lastname: Li
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Bradfield
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhang
authors.forename: Frank D
authors.initials: FD
authors.lastname: Mentch
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Sleiman
authors.forename: Cecilia E
authors.initials: CE
authors.lastname: Kim
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Glessner
authors.forename: Cuiping
authors.initials: C
authors.lastname: Hou
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Keating
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Thomas
authors.forename: Maria L
authors.initials: ML
authors.lastname: Garris
authors.forename: Sandra
authors.initials: S
authors.lastname: Deliard
authors.forename: Edward C
authors.initials: EC
authors.lastname: Frackelton
authors.forename: F George
authors.initials: FG
authors.lastname: Otieno
authors.forename: Rosetta M
authors.initials: RM
authors.lastname: Chiavacci
authors.forename: Robert I
authors.initials: RI
authors.lastname: Berkowitz
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
authors.forename: Struan F A
authors.initials: SF
authors.lastname: Grant
mesh_terms: D000328:Adult; D002648:Child; D022004:Chromosome Structures; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D016678:Genome; D055106:Genome-Wide Association Study; D005838:Genotype; D006128:Growth / Q000235:genetics; D055428:Growth Differentiation Factor 5; D025743:HMGA2 Protein / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012106:Research; D044465:White People / Q000235:genetics
chemical_list: D055428:Growth Differentiation Factor 5; D025743:HMGA2 Protein