title: Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50-<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.
authors.affiliation: National Cancer Institute, Bethesda, Maryland 20852, USA. christian.abnet@nih.gov
authors.forename: Christian C
authors.initials: CC
authors.lastname: Abnet
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: James M
authors.initials: JM
authors.lastname: Shikany
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.forename: David S
authors.initials: DS
authors.lastname: Campbell
authors.forename: Peter T
authors.initials: PT
authors.lastname: Campbell
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Abraham M Y
authors.initials: AM
authors.lastname: Nomura
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D014807:Vitamin D