title: Does a helicase activity help mismatch repair in eukaryotes?
abstract: Mismatch repair (MMR) corrects innate DNA replication infidelities. Many components of eukaryotic MMR have been identified, the molecular mechanism of MMR has been largely demonstrated, and furthermore the nick-directed MMR reactions have been reconstituted with purified human proteins in vitro. However, some fundamental questions still remain to be answered. One such question is whether a DNA helicase activity is required for MMR in eukaryotes. This short review presents an overview of the interactions between eukaryotic DNA helicases and MMR factors, and suggests a possible mechanism for how DNA helicases may be involved in repair of DNA mismatches.
authors.affiliation: Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Limin
authors.initials: L
authors.lastname: Song
authors.forename: Fenghua
authors.initials: F
authors.lastname: Yuan
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D020137:Base Pair Mismatch; D050976:Basic-Leucine Zipper Transcription Factors / Q000378:metabolism; D004265:DNA Helicases / Q000378:metabolism*; D053843:DNA Mismatch Repair; D004926:Escherichia coli / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D056890:Eukaryota; D051856:Fanconi Anemia Complementation Group Proteins / Q000378:metabolism; D006801:Humans; D053484:RecQ Helicases / Q000378:metabolism
chemical_list: C102108:BACH1 protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D029968:Escherichia coli Proteins; D051856:Fanconi Anemia Complementation Group Proteins; C506746:UvrD protein, E coli; D004265:DNA Helicases; D053484:RecQ Helicases