title: Two new triterpenoids from the roots of Actinidia chinensis.
abstract: Two new triterpenoids (1, 2), together with one flavonoid glycoside and thirteen known triterpenoids were isolated from the roots of Actinidia chinensis Planch (Actinidiaceae). The structures of the new constituents were elucidated as 12α-chloro-2α, 3β, 13β, 23-tetrahydroxyolean-28-oic acid-13-lactone (1), 2α, 3α, 19α, 23, 24-pentahydroxyurs-12-en-28-oic acid (2). Structure elucidation was accomplished by 1D, 2D NMR spectra (HMQC, HMBC, (1)H-(1)H COSY, TOCSY, and NOESY) and mass spectrometry (ESIMS). Moreover, two known triterpenoids showed positive cytotoxic activity against LOVO and HepG2 cell lines.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Xu
authors.forename: Zhao-Bao
authors.initials: ZB
authors.lastname: Xiang
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Jin
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Hai-Sheng
authors.initials: HS
authors.lastname: Chen
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C557760:12alpha-chloro-2alpha,3beta,13beta,23-tetrahydroxyolean-28-oic acid-13-lactone; C557761:2alpha,3beta,13beta,23,24-pentahydroxyurs-12-en-28-oic acid; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes