LKB1 and Src: antagonistic regulators of tumor growth and metastasis.
In this issue of Cancer Cell, Carretero and colleagues report that Src and FAK signaling pathways are activated in lung cancers when the tumor suppressor LKB1 is deleted. These findings suggest the use of unique combinatorial therapies for treatment of lung cancers.
Slack-Davis
Jill
J
Department of Microbiology and Cancer Center, University of Virginia, Charlottesville, VA 22908, USA.
Dasilva
John O
JO
Parsons
Sarah J
SJ