title: Takotsubo cardiomyopathy: a unique cardiomyopathy with variable ventricular morphology.
abstract: Takotsubo cardiomyopathy is an important differential diagnosis of acute coronary syndrome. It is characterized by normal (or near-normal) coronary arteries, regional wall motion abnormalities that extend beyond a single coronary vascular bed, and often, a precipitating stressor. Variants of the classical left ventricular apical ballooning, including mid- or basal left ventricular wall motion abnormalities, are increasingly recognized. Takotsubo cardiomyopathy is not rare, and heightened awareness of this unique cardiomyopathy likely will lead to a higher reported incidence. Diagnosis of takotsubo cardiomyopathy has important implications for clinical management at presentation and afterward. The long-term prognosis is generally favorable; however, a small subset has potentially life-threatening complications during the initial presentation. The pathophysiologic mechanism is unknown, but catecholamine excess likely has a central role.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona 85259, USA. hurst.todd@mayo.edu
authors.forename: R Todd
authors.initials: RT
authors.lastname: Hurst
authors.forename: Abhiram
authors.initials: A
authors.lastname: Prasad
authors.forename: J Wells
authors.initials: JW
authors.lastname: Askew
authors.forename: Partho P
authors.initials: PP
authors.lastname: Sengupta
authors.forename: A Jamil
authors.initials: AJ
authors.lastname: Tajik
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers