title: Revascularization versus medical therapy for renal artery stenosis: antihypertensive drugs and renal outcome.
abstract: Endovascular procedures may play a role in renal artery stenosis (RAS) treatment in attempt to preserve renal function and improve hypertension control. We determined renal outcome and the incidence of restenosis in patients with RAS treated with renal percutaneous transluminal angioplasty and stenting (RPTAs) and medical therapy versus patients with RAS treated only with medical therapy. We performed an observational study based on 93 patients with RAS. In all, 53 patients underwent RPTAs in association with medical therapy and 40 patients were only treated pharmacologically. In patients receiving RPTAs, a better renal outcome, a decrease of restenosis rate, and systolic-diastolic blood pressure were associated with angiotensin receptor blockers (ARBs) + angiotensin-converting enzyme inhibitors (ACE-is) therapy. In patients treated with medical therapy alone, renal improvement was related to ARBs in association with BBs (β-blockers; P < .0001). This study suggests that medical therapy may exert beneficial effects in patients with RAS.
authors.affiliation: Department of Nephrology, Sapienza, University of Rome, Italy. ciancirosario@tin.it
authors.forename: Rosario
authors.initials: R
authors.lastname: Cianci
authors.forename: Paola
authors.initials: P
authors.lastname: Martina
authors.forename: Francesca
authors.initials: F
authors.lastname: Borghesi
authors.forename: Domenico
authors.initials: D
authors.lastname: di Donato
authors.forename: Lelio
authors.initials: L
authors.lastname: Polidori
authors.forename: Silvia
authors.initials: S
authors.lastname: Lai
authors.forename: Giada
authors.initials: G
authors.lastname: Ascoli
authors.forename: Irene
authors.initials: I
authors.lastname: de Francesco
authors.forename: Alvaro
authors.initials: A
authors.lastname: Zaccaria
authors.forename: Antonietta
authors.initials: A
authors.lastname: Gigante
authors.forename: Biagio
authors.initials: B
authors.lastname: Barbano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012078:Renal Artery Obstruction / Q000188:drug therapy / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents