title: Acetaminophen reduces social pain: behavioral and neural evidence.
abstract: Pain, whether caused by physical injury or social rejection, is an inevitable part of life. These two types of pain-physical and social-may rely on some of the same behavioral and neural mechanisms that register pain-related affect. To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, may also reduce behavioral and neural responses to social rejection. In two experiments, participants took acetaminophen or placebo daily for 3 weeks. Doses of acetaminophen reduced reports of social pain on a daily basis (Experiment 1). We used functional magnetic resonance imaging to measure participants' brain activity (Experiment 2), and found that acetaminophen reduced neural responses to social rejection in brain regions previously associated with distress caused by social pain and the affective component of physical pain (dorsal anterior cingulate cortex, anterior insula). Thus, acetaminophen reduces behavioral and neural responses associated with the pain of social rejection, demonstrating substantial overlap between social and physical pain.
authors.affiliation: Department of Psychology, University of Kentucky, Lexington, KY 40506-0044, USA. nathan.dewall@uky.edu
authors.forename: C Nathan
authors.initials: CN
authors.lastname: Dewall
authors.forename: Geoff
authors.initials: G
authors.lastname: Macdonald
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Webster
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Masten
authors.forename: Roy F
authors.initials: RF
authors.lastname: Baumeister
authors.forename: Caitlin
authors.initials: C
authors.lastname: Powell
authors.forename: David
authors.initials: D
authors.lastname: Combs
authors.forename: David R
authors.initials: DR
authors.lastname: Schurtz
authors.forename: Tyler F
authors.initials: TF
authors.lastname: Stillman
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Tice
authors.forename: Naomi I
authors.initials: NI
authors.lastname: Eisenberger
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D001921:Brain / Q000033:anatomy & histology; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010146:Pain / Q000517:prevention & control* / Q000523:psychology*; D012016:Reference Values; D012059:Rejection, Psychology; D012919:Social Behavior; D012928:Social Desirability; D013315:Stress, Psychological / Q000523:psychology; D013334:Students / Q000523:psychology
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen