title: A Hydroxyurea-induced Leg Ulcer.
abstract: Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration, and xerosis. The leg ulcers were refractory to conventional treatment. She had been taking oral hydroxyurea since being diagnosed with essential thrombocytosis in 2002. Hence, we suspected hydroxyurea-induced leg ulcers and discontinued her hydroxyurea treatment; the ulcers gradually healed thereafter. We present a rare case of hydroxyurea-induced leg ulcers in Korea.
authors.affiliation: Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
authors.forename: Seon-Wook
authors.initials: SW
authors.lastname: Hwang
authors.forename: Soon-Kwon
authors.initials: SK
authors.lastname: Hong
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Seo
authors.forename: Deborah
authors.initials: D
authors.lastname: Lee
authors.forename: Ho-Suk
authors.initials: HS
authors.lastname: Sung