title: Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.
abstract: The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: M R
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: E K
authors.initials: EK
authors.lastname: Perimal
authors.forename: M N
authors.initials: MN
authors.lastname: Akhtar
authors.forename: A S
authors.initials: AS
authors.lastname: Mohamad
authors.forename: M H
authors.initials: MH
authors.lastname: Khalid
authors.forename: N A
authors.initials: NA
authors.lastname: Tasrip
authors.forename: F
authors.initials: F
authors.lastname: Mokhtar
authors.forename: Z A
authors.initials: ZA
authors.lastname: Zakaria
authors.forename: N H
authors.initials: NH
authors.lastname: Lajis
authors.forename: D A
authors.initials: DA
authors.lastname: Israf
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D027343:Rhizome; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; C403304:zerumbone; D002351:Carrageenan