title: Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.
abstract: A 62-year-old man, with a 20-year history of seborrhoeic dermatitis, presented with a worsening of his dermatitis. He had previously been demonstrated to be allergic to various topical corticosteroids, so he had been using an emollient cream (Sebclair), containing piroctone olamine and various anti-inflammatory substances, for 6 months, with good effect. Patch testing to the cream and its ingredients revealed positive reactions to both propyl gallate and pentylene glycol. A positive reaction to propylene glycol was also detected, whereas patch testing to butylene glycol was negative. Complete remission followed avoidance of the offending substances.
authors.affiliation: Department of Internal Medicine, Immunology and Infectious Diseases, Dermatology Clinic, University of Bari, Bari, Italy. c.foti@dermatologia.uniba.it
authors.forename: Caterina
authors.initials: C
authors.lastname: Foti
authors.forename: Domenico
authors.initials: D
authors.lastname: Bonamonte
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Cassano
authors.forename: Anna
authors.initials: A
authors.lastname: Conserva
authors.forename: Gino A
authors.initials: GA
authors.lastname: Vena
mesh_terms: D000287:Administration, Topical; D000975:Antioxidants / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D012628:Dermatitis, Seborrheic / Q000188:drug therapy; D004338:Drug Combinations; D004643:Emollients / Q000009:adverse effects*; D004983:Ethanolamines / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D005500:Follow-Up Studies; D006018:Glycols / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010420:Pentanes; D014677:Pharmaceutical Vehicles / Q000009:adverse effects; D011435:Propyl Gallate / Q000009:adverse effects*; D019946:Propylene Glycol / Q000009:adverse effects; D011728:Pyridones / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D004643:Emollients; D004983:Ethanolamines; D006018:Glycols; D010420:Pentanes; D014677:Pharmaceutical Vehicles; D011728:Pyridones; C578469:1,5-pentanediol; D019946:Propylene Glycol; D011435:Propyl Gallate; C052599:piroctone olamine