Cytosporolides A-C, antimicrobial meroterpenoids with a unique peroxylactone skeleton from Cytospora sp.
Cytosporolides A-C (1-3), three caryophyllene-derived meroterpenoids with a unique peroxylactone skeleton, were isolated from cultures of the fungus Cytospora sp. Their structures were elucidated by NMR spectroscopy, and the absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke's method. Compounds 1-3 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Streptococcus pneumoniae.
Li
Yan
Y
Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
Niu
Subin
S
Sun
Bingda
B
Liu
Shuchun
S
Liu
Xingzhong
X
Che
Yongsheng
Y
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000890:Anti-Infective Agents; D007783:Lactones; D013729:Terpenes