title: Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
abstract: We conducted a genome-wide association study for testicular germ cell tumor, genotyping 298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating associations in a further 664 cases and 3,456 controls. We identified three new susceptibility loci, two of which include genes that are involved in telomere regulation. We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1.54, P=1.14x10(-23); rs2736100, OR=1.33, P=7.55x10(-15)). We also identified a locus on chromosome 12 (rs2900333, OR=1.27, P=6.16x10(-10)) that contains ATF7IP, a regulator of TERT expression. Finally, we identified a locus on chromosome 9 (rs755383, OR=1.37, P=1.12x10(-23)), containing the sex determination gene DMRT1, which has been linked to teratoma susceptibility in mice.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK. clare.turnbull@icr.ac.uk
authors.forename: Clare
authors.initials: C
authors.lastname: Turnbull
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rapley
authors.forename: Sheila
authors.initials: S
authors.lastname: Seal
authors.forename: David
authors.initials: D
authors.lastname: Pernet
authors.forename: Anthony
authors.initials: A
authors.lastname: Renwick
authors.forename: Deborah
authors.initials: D
authors.lastname: Hughes
authors.forename: Michelle
authors.initials: M
authors.lastname: Ricketts
authors.forename: Rachel
authors.initials: R
authors.lastname: Linger
authors.forename: Jeremie
authors.initials: J
authors.lastname: Nsengimana
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Deloukas
authors.forename: Robert A
authors.initials: RA
authors.lastname: Huddart
authors.forename: D Timothy
authors.initials: DT
authors.lastname: Bishop
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stratton
authors.forename: Nazneen
authors.initials: N
authors.lastname: Rahman
mesh_terms: D000328:Adult; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: C501309:ATF7IP protein, human; C110547:DMRT1 protein; D012097:Repressor Proteins; D014157:Transcription Factors; C509186:TERT protein, human; D019098:Telomerase