title: Evolving anatomic, functional, and molecular imaging in the early detection and prognosis of hypertrophic cardiomyopathy.
abstract: Evolving imaging modalities in hypertrophic cardiomyopathy (HCM), such as tissue Doppler, speckle tracking, measures of myocardial blood flow, and cardiac magnetic resonance with gadolinium enhancement, have advanced our understanding of the pathogenesis of myocardial dysfunction in hypertrophic cardiomyopathy. These modalities have the potential to differentiate HCM from other causes of left ventricular hypertrophy when there is uncertainty about the diagnosis and to identify affected individuals in the pre-clinical phase of the disease process. Furthermore, preliminary data suggests that functional imaging techniques may add incremental value to conventional risk stratification tools to identify individuals at high risk for sudden death or progression to congestive heart failure.
authors.affiliation: Zena and Michael A. Wiener Cardiovascular Institute, and the Marie-Josee and Henry R. Kravis Cardiovascular Health Center, Mount Sinai Medical Center, The Mount Sinai School of Medicine, New York, NY, 10029, USA. valentin.fuster@mssm.edu
authors.forename: Valentin
authors.initials: V
authors.lastname: Fuster
authors.forename: Sarina
authors.initials: S
authors.lastname: van der Zee
authors.forename: Marc A
authors.initials: MA
authors.lastname: Miller
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods*; D018450:Disease Progression; D042241:Early Diagnosis; D015150:Echocardiography, Doppler; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D057054:Molecular Imaging; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index