Childhood and adolescent orofacial granulomatosis is strongly associated with Crohn's disease and responds to intralesional corticosteroids.
We present seven cases of orofacial granulomatosis occurring in paediatric patients aged 6-16 years. All patients were investigated for Crohn's disease and a strong association was found. All patients were treated with intralesional corticosteroid injections with excellent clinical responses. We review the literature and discuss the epidemiological association between childhood orofacial granulomatosis and Crohn's disease, as well as various treatment options, and propose a treatment protocol that was efficacious and well tolerated in all our patients.
Tuxen
Alana J
AJ
The Royal Children's Hospital, Parkville, Victoria, Australia. alanatuxen@yahoo.com
Orchard
David
D
D000287:Administration, Topical; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage; D002648:Child; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D051261:Granulomatosis, Orofacial / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional / Q000009:adverse effects; D008297:Male; D010146:Pain / Q000209:etiology; D059408:Pain Management; D016896:Treatment Outcome; D014732:Vibration / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000779:Anesthetics, Local