title: Adult stem cells therapy for urine incontinence in women.
abstract: The past few years brought high development in obtaining and culturing autologous adult stem cells. In this paper we review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells (MSCs) can be obtained from bone marrow but it is associated with a painful biopsy procedure. Collection of muscle-derived stem cells (MDSCs) is less harmful because the skeletal muscle biopsy is performed with a small caliber needle in local anesthesia. The stem-based therapy could be the next step in the treatment of urinary incontinence. There are still many elements of therapy such as effectiveness or long-term side effects which need to be researched.
authors.affiliation: Department of Gynecology and Oncology, Collegium Medium Jagiellonian University of Kraków. ksw@cm-uj.krakow.pl
authors.forename: Klaudia
authors.initials: K
authors.lastname: Stangel-Wójcikiewicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Majka
authors.forename: Antoni
authors.initials: A
authors.lastname: Basta
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stec
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pabian
authors.forename: Monika
authors.initials: M
authors.lastname: Piwowar
authors.forename: Michael B
authors.initials: MB
authors.lastname: Chancellor
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000637:transplantation*; D005260:Female; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D032446:Myoblasts / Q000637:transplantation; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D023822:Tissue Engineering / Q000379:methods; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000628:therapy*; D014563:Urodynamics; D016387:Women's Health