Treatment of postsurgical pyoderma gangrenosum with a high-potency topical steroid.
Pyoderma gangrenosum is a rare disease characterized by chronic, nonhealing, noninfectious ulcers that can become exacerbated by trauma or manipulation, including surgical treatment. We describe the case of a 30-year-old woman who presented with a large ulcer at the site of an excisional cervical lymph node biopsy; she also had a smaller ulcer at the site of an earlier biopsy that had been previously well healed. The ulcers persisted despite local care, and the larger ulcer was exacerbated by surgical debridement. Histopathology revealed the presence of intense neutrophilic infiltrates with sterile microabscesses-a finding consistent with pyoderma gangrenosum. With 9 weeks of treatment with a high-potency topical steroid, both ulcers gradually healed.
Hawryluk
Elena Balestreire
EB
Department of Dermatology, University of Pittsburgh, 145 Lothrop Hall, 190 Lothrop St., Pittsburgh, PA 15213, USA.
Penn
Sara Kaprove
SK
Wasko
Mary-Chester
MC
Johnson
Jonas T
JT
Ferris
Laura Korb
LK
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002990:Clobetasol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic; D011183:Postoperative Complications / Q000188:drug therapy*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000382:microbiology; D012859:Sjogren's Syndrome; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D002990:Clobetasol