title: Allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning for a child with recurrent anaplastic large cell lymphoma.
abstract: Anaplastic large cell lymphoma (ALCL) is chemosensitive, but recurrence is frequently observed. Allogeneic hematopoietic stem cell transplantation (HSCT) has recently been reported to be effective against recurrent disease, suggesting a graft-versus-lymphoma effect. We present a 3-year-old child with recurrent ALCL who underwent HSCT from an HLA-1-locus mismatched cord blood unit following reduced intensity conditioning with fludarabine, melphalan, and low-dose thoraco-abdominal irradiation. Engraftment was uneventful, but grade III acute graft-versus-host disease was observed. He is well and free of disease 25 months after HSCT, which implies that reduced intensity conditioning may allow a sufficient graft-versus-lymphoma effect against ALCL while lessening treatment-related toxicities.
authors.affiliation: Department of Pediatrics, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Japan. ohta@ped.med.osaka-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ohta
authors.forename: Shigenori
authors.initials: S
authors.lastname: Kusuki
authors.forename: Hisao
authors.initials: H
authors.lastname: Yoshida
authors.forename: Emiko
authors.initials: E
authors.lastname: Sato
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Hashii
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ozono
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D018572:Disease-Free Survival; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology / Q000628:therapy*; D008297:Male; D012008:Recurrence; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous