CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis.
OBJECTIVE
To clarify the association between CYP2E1 PstI/RsaI polymorphism and susceptibility to colorectal cancer.


METHODS
A meta-analysis based on 10 eligible case-control studies involving 4979 cases and 6012 controls was carried out to summarize the data on the association between CYP2E1 RsaI/PstI polymorphism and colorectal cancer risk.


RESULTS
In comparison of the homozygote c2c2 and c2 carriers (c1c2 + c2c2) and the homozygous wild-type genotype (c1c1), no association was found between CYP2E1 RsaI/PstI polymorphism and colorectal cancer risk [odds ratio (OR) = 1.24 (95% CI: 0.93-1.66) for c2c2; OR = 1.02 (95% CI: 0.88-1.19) for c2 carriers]. In stratified analysis, Caucasians with c2c2 homozygote appeared to have an increased risk of colorectal cancer (OR = 2.67, 95% CI: 1.03-6.89, P = 0.043), no significant associations were found in other groups.


CONCLUSIONS
c2c2 homozygote of CYP2E1 PstI/RsaI polymorphism may be associated with the increased risk of colorectal cancer in Caucasians, which needs further investigations.
Zhou
Guo-Wu
GW
Department of Respiration, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Hu
Jia
J
Li
Qiang
Q
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005838:Genotype; D006720:Homozygote; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D044465:White People / Q000235:genetics
D019392:Cytochrome P-450 CYP2E1; C024388:CTGCAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; C040158:GTAC-specific type II deoxyribonucleases