Effect of prior exercise on thermal sensitivity of malignant hyperthermia-susceptible muscle.
Malignant hyperthermia (MH) episodes may occur upon exposure to halogenated anesthetics, during resistance and endurance exercise, and in response to thermal stress. The purpose of this study was to investigate the effects of prior eccentric and concentric (i.e., wheel running) exercise on the thermal sensitivity of isolated MH-susceptible mouse muscle (RyR1(Y522S/wt)). Eccentric, but not concentric, exercise attenuated the thermal sensitivity of MH-susceptible muscle.
Corona
Benjamin T
BT
Department of Kinesiology & Health, PO Box 3975, Georgia State University, Atlanta, Georgia 30302-3975, USA.
Hamilton
Susan L
SL
Ingalls
Christopher P
CP
D000704:Analysis of Variance; D000818:Animals; D004198:Disease Susceptibility; D008305:Malignant Hyperthermia / Q000235:genetics / Q000503:physiopathology*; D051379:Mice; D008822:Mice, Transgenic; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010805:Physical Conditioning, Animal