title: [Distribution of 33 elements in lung cancer tissues, paracancerous lung tissues and benign lung tissues of patients with lung cancer].
abstract: OBJECTIVE
  To analyze the contents and distribution of 33 elements in the samples of lung cancer tissues, paracancerous lung tissues and benign lung tissues of patients with lung cancer.
  
  
  METHODS
  14 samples of lung cancer tissue, paracancerous lung tissue and benign lung tissue were collected from the patients with lung cancer in the high lung cancer rate area of our country. The samples were determined by inductively coupled plasma mass spectrometry after microwave digestion. SAS 9.0 software was used to analyze the data.
  
  
  RESULTS
  The contents of 12 elements such as B, V, Fe, Ni, Cu, Zn, Ga, Se, Rb, Cd, Pb and Bi were significant different between the lung cancer tissue and the normal (P < 0.05). The concentrations of elements in different tissuess as independent variables were analyzed in the multiple conditional logistic regression model. It was suggested that Fe and Zn might might be the protective factors while Ni, Cu and Pb the risk factors for lung cancer. The results of Pearson correlation test showed there was a significant positive correlation between Fe and Zn, Ni and Cu, Cu and Pb respectively. While Fe and Ni, Fe and Cu, Ni and Zn, Cu and Zn were negatively correlated to each other (P < 0.05). Cu/Zn ratio were much higher in lung cancer tissues than those in the paracancerous lung tissues and benign lung tissues.
  
  
  CONCLUSIONS
  The contents and distribution of some elements were related to the generation and development of lung cancer.
authors.affiliation: The Civil and Environment Engineering School of University of Science and Technology Beijing, Beijing 100083, China. zhanglinlin921@sina.com
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.forename: Qianli
authors.initials: Q
authors.lastname: Ma
authors.forename: Guoping
authors.initials: G
authors.lastname: Wu
authors.forename: Yunchao
authors.initials: Y
authors.lastname: Huang
authors.forename: Fusheng
authors.initials: F
authors.lastname: Wei
mesh_terms: D006801:Humans; D008168:Lung / Q000737:chemistry*; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D014018:Tissue Distribution; D014131:Trace Elements / Q000032:analysis*
chemical_list: D014131:Trace Elements