title: A power-law distribution of inter-spike intervals in renal sympathetic nerve activity in salt-sensitive hypertension-induced chronic heart failure.
abstract: To assess sympathetic variability in chronic heart failure (CHF), we evaluated a distribution of inter-spike intervals (ISIs) in renal sympathetic nerve activity (RSNA) in salt-sensitive hypertension-induced CHF (DSSH-CHF) rats. Dahl salt-sensitive rats were fed an 8% NaCl diet for 9 weeks to induce salt-sensitive hypertension-induced CHF. ISIs in RSNA were obtained from chronically instrumented conscious rats, and counts (frequency) and ranks of ISIs in RSNA were plotted with a histogram. We found that ISIs in RSNA followed a power-law distribution in rats, and the power-law distribution of ISIs for RSNA in DSSH-CHF rats was significantly different from that in normal rats. These results indicated that sympathetic variability may be significantly different between salt-sensitive hypertension-induced CHF and healthy individuals, which suggests that sympathetic variability may be used to predict abnormality of the sympathetic regulatory system.
authors.affiliation: Department of Physiology, National Defense Medical College, Tokorozawa, Saitama, Japan. kemu@ndmc.ac.jp
authors.forename: Takehito
authors.initials: T
authors.lastname: Kemuriyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohta
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Maruyama
authors.forename: Megumi
authors.initials: M
authors.lastname: Tandai-Hiruma
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kato
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishida
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004562:Electrocardiography; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications*; D007668:Kidney / Q000294:innervation*; D051381:Rats; D020303:Rats, Inbred Dahl; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D013045:Species Specificity; D013564:Sympathetic Nervous System / Q000502:physiology*