title: Flow cytometric immunophenotypic characteristics of 36 cases of plasma cell leukemia.
abstract: Prospective flow cytometric analysis of antigens expression on bone marrow and peripheral blood plasma cells of 36 plasma cell leukemia (PCL) patients enabled to establish the following immunophenotype of leukemic plasma cell: CD38(++), CD138(+), CD54(+), CD49d(+), CD29(+), CD44(+), CD126(+), CD19(-), CD45(-). In one-third of patients PCL cells express CD56, CD71 and CD117. Expression of CD54 on plasma cells was higher as compared to expression of adhesion molecules CD11a, CD18 and CD11b (p<0.01). Expression of CD18, CD11a, CD11b was lower on bone marrow and higher on peripheral blood cells. In conclusion, impaired expression of adhesion molecules such as CD11a/CD18 or CD56 may explain hematogenic dissemination characterizing PCL.
authors.affiliation: Department of Hematology, Institute of Hematology and Transfusion Medicine, 14 I Gandhi Street, 02-776 Warsaw, Poland. mkraj@ihit.waw.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Kraj
authors.forename: Joanna
authors.initials: J
authors.lastname: Kopeć-Szlęzak
authors.forename: Ryszard
authors.initials: R
authors.lastname: Pogłód
authors.forename: Barbara
authors.initials: B
authors.lastname: Kruk
mesh_terms: D015703:Antigens, CD / Q000032:analysis* / Q000096:biosynthesis; D002469:Cell Separation; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D016130:Immunophenotyping; D007952:Leukemia, Plasma Cell / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*
chemical_list: D015703:Antigens, CD