[A new alignment-free sequence analysis based on the distribution of K-tuple].
Based on the distribution of K-tuple in complete genome, a method without doing sequence alignment to infer difference of biological sequence is proposed in this paper. The method can be used to measure the difference of distribution on K-tuple between the native DNA sequences and the corresponding randomized ones. Applied to construct phylogenetic trees of the complete mitochondrial genomes of 26 species of placental mammals, with K increasing, it yields phylogenetic trees of which the classification effect increasingly matches the result widely recognised by the biological field. The final results show that the phylogenetic trees built by this method is more reasonable than by other alignment-free sequence methods.
Shen
Juan
J
College of Science, Northwest A and F University, Yangling 712100, China. shenjuan0927@126.com
Wu
Wen-Wu
WW
Xie
Xiao-Li
XL
Guo
Man-Cai
MC
Yuan
Zhi-Fa
ZF
D000818:Animals; D006801:Humans; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA