Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE epsilon4 allele resulted in a global p value of 0.56.
Lescai
Francesco
F
Division of Research Strategy, University College London, London, UK. f.lescai@ucl.ac.uk
Pirazzini
Chiara
C
D'Agostino
Giuseppe
G
Santoro
Aurelia
A
Ghidoni
Roberta
R
Benussi
Luisa
L
Galimberti
Daniela
D
Federica
Esposito
E
Marchegiani
Francesca
F
Cardelli
Maurizio
M
Olivieri
Fabiola
F
Nacmias
Benedetta
B
Sorbi
Sandro
S
Bagnoli
Silvia
S
Tagliavini
Fabrizio
F
Albani
Diego
D
Martinelli Boneschi
Filippo
F
Binetti
Giuliano
G
Forloni
Gianluigi
G
Quadri
Pierluigi
P
Scarpini
Elio
E
Franceschi
Claudio
C
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000091363:Protocadherins; D044465:White People / Q000235:genetics
D053327:Apolipoprotein E4; D015820:Cadherins; C404498:PCDH11X protein, human; D000091363:Protocadherins