title: [Association analysis between SNPs of the growth hormone receptor gene and growth traits in arctic fox].
abstract: Using single-strand conformation polymorphism (PCR-SSCP) and DNA sequencing, single nucleotide polymorphisms (SNPs) of growth hormone receptor (GHR) gene were detected in an arctic fox population. Correlation analysis between GHR polymorphisms and growth traits were carried out using the appropriate model. Four SNPs, G3A in the 5'UTR, C99T in the first exon, T59C and G65A in the fifth exon were identified on the arctic fox GHR gene. The G3A and C99T polymorphisms of GHR were associated with female fox body weight (Pamp;0.05) and the T59C and G65A polymorphisms of GHR were associated with male fox body weight (Pamp;0.05) and the skin length of the female fox (Pamp;0.01). Therefore, marker assistant selection on body weight and skin length of arctic foxes using these SNPs can be applied to get big and high quality arctic foxes.
authors.affiliation: Department of Animal Science, Northeast Agriculture University, Harbin 150030, China. dzhh119@163.com
authors.forename: Zhi-Heng
authors.initials: ZH
authors.lastname: DU
authors.forename: Zong-Yue
authors.initials: ZY
authors.lastname: Liu
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Bai
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D005589:Foxes / Q000235:genetics; D005838:Genotype; D006128:Growth; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D011986:Receptors, Somatotropin / Q000235:genetics*
chemical_list: D011986:Receptors, Somatotropin