Cleft lip and palate in family members of cancer survivors.
The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75–17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.
Taioli
E
E
Department of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA. emanuela.taioli@downstate.edu
Ragin
C
C
Robertson
L
L
Linkov
F
F
Thurman
N E
NE
Vieira
A R
AR
D000328:Adult; D000368:Aged; D002971:Cleft Lip / Q000453:epidemiology*; D002972:Cleft Palate / Q000453:epidemiology*; D015897:Comorbidity; D005190:Family; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D010414:Pennsylvania / Q000453:epidemiology; D011795:Surveys and Questionnaires; D017741:Survivors / Q000706:statistics & numerical data*; D013736:Testicular Neoplasms / Q000453:epidemiology; D055815:Young Adult