[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats].
New data on complex realization of anxiolytic, antidepressive and antinociceptive effects of prenatal injections of a 5-HT1A agonist buspirone were obtained in prenatally stressed adult rats. Buspirone was injected to female rats from the 9th to 21st days of pregnancy; during the last week of pregnancy buspirone was injected 10 min before immobilization stress. In the adult offspring of both sexes, behavioral indices of tonic pain response in the formalin test and the indices of depression in the forced swim test were investigated. The choice of the target was defined in accordance with available literature data on the role of 5-HT1A receptors in the mechanisms of prenatal stress, of formation of the ascending link of the nociceptive system, of development of depression, and in the mechanisms of the treatment ofnociceptive information. Prenatal stress increased the duration of licking and the time of immobility, the indices of tonic pain and depression in the rats of both sexes. Buspirone evoked the decrease of the indices investigated in prenatally stressed rats in both tests in comparison with the relevant indices in prenatally stressed rats that were not subjected to buspirone. Thereby, it has been demonstrated that buspirone normalized the indices of the tonic pain response modified by prenatal stress; a considerable decrease of the index of depression suggests that there are differences in mechanisms of antinociceptive and antidepressive effects of buspirone. The data on complex realization of anxiolytic, antidepressive and antinociceptive effects ofbuspirone stimulate the attention of clinicians and prompt further investigations in this direction.
Butkevich
I P
IP
Mikhaĭlenko
V A
VA
Vershinina
E A
EA
Semenov
P O
PO
Otellin
V A
VA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002065:Buspirone / Q000009:adverse effects* / Q000494:pharmacology; D003863:Depression / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D007103:Immobilization; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D010146:Pain; D010147:Pain Measurement; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D058829:Serotonin 5-HT1 Receptor Antagonists; D017366:Serotonin Receptor Agonists / Q000009:adverse effects* / Q000494:pharmacology; D013312:Stress, Physiological
D058829:Serotonin 5-HT1 Receptor Antagonists; D017366:Serotonin Receptor Agonists; D002065:Buspirone