Cell adhesion: implication in tumor progression.
Changes in the adhesive properties of neoplastic cells, as well as intracellular signaling mediated by cell surface adhesion molecules, play essential roles in the development and progression of cancer. In this review, we summarize the recent progress in understanding the biology of cell adhesion molecules (CAMs) as well as their clinical significance as prognostic biomarkers or as potential therapeutic targets in a variety of malignancies.
Zigler
M
M
Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Dobroff
A S
AS
Bar-Eli
M
M
D000970:Antineoplastic Agents / Q000627:therapeutic use; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D019087:Selectins / Q000502:physiology
D000970:Antineoplastic Agents; D015820:Cadherins; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; D009363:Neoplasm Proteins; D019087:Selectins