Regulating the regulator: Rsp5 ubiquitinates the proteasome.
In this issue of Molecular Cell, Isasa et al. (2010) show that the Rsp5 ubiquitin ligase regulates substrate recruitment to the 26S proteasome by ubiquitinating Rpn10, the proteasome's polyubiquitin degradation signal receptor.
Haas
Arthur L
AL
Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine and the Stanley S Scott Cancer Center, 1901 Perdido Street, New Orleans, LA 70112, USA. ahaas@lsuhsc.edu