title: Lumbar intervertebral disc abnormalities: comparison of quantitative T2 mapping with conventional MR at 3.0 T.
abstract: OBJECTIVE
  To assess the relationship of morphologically defined lumbar disc abnormalities with quantitative T2 mapping.
  
  
  METHODS
  Fifty-three patients, mean age 39 years, with low back pain were examined by MRI at 3 T (sagittal T1-fast spin echo (FSE), three-plane T2-FSE for morphological MRI, multi-echo spin echo for T2 mapping). All discs were classified morphologically. Regions of interest (ROIs) for the annulus were drawn. The space in between was defined as the nucleus pulposus (NP). To evaluate differences between the classified groups, univariate ANOVA with post hoc Games-Howell and paired two-tailed t tests were used.
  
  
  RESULTS
  In 265 discs we found 39 focal herniations, 10 annular tears, 123 bulging discs and 103 "normal discs". T2 values of the NP between discs with annular tear and all other groups were statistically significantly different (all p ≤ 0.01). Discs with annular tears showed markedly lower NP T2 values than discs without. The difference in NP T2 values between discs with focal herniation and normal discs (p = 0.005) was statistically significant. There was no difference in NP T2 values between bulging and herniated discs (p = 0.11)
  
  
  CONCLUSIONS
  Quantitative T2 mapping of the nucleus pulposus of the intervertebral disc in the lumbar spine at 3 T reveals significant differences in discs with herniation and annular tears compared with discs without these abnormalities.
authors.affiliation: Department of Radiology, MR Centre-Highfield MR, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria. siegfried.trattnig@meduniwien.ac.at
authors.forename: Siegfried
authors.initials: S
authors.lastname: Trattnig
authors.forename: David
authors.initials: D
authors.lastname: Stelzeneder
authors.forename: Sabine
authors.initials: S
authors.lastname: Goed
authors.forename: Michael
authors.initials: M
authors.lastname: Reissegger
authors.forename: Tallal C
authors.initials: TC
authors.lastname: Mamisch
authors.forename: Tatjana
authors.initials: T
authors.lastname: Paternostro-Sluga
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.forename: Pavol
authors.initials: P
authors.lastname: Szomolanyi
authors.forename: Goetz H
authors.initials: GH
authors.lastname: Welsch
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000293:injuries* / Q000473:pathology*; D007405:Intervertebral Disc Displacement / Q000175:diagnosis*; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult