[Pain mechanisms in chronic musculoskeletal conditions].
Manifestations, quantitative assessment, genetic predisposition and mechanisms in musculoskeletal pain are presented. Quantitative sensory testing provides an opportunity to evaluate pain manifestations and mechanisms. Peripheral sensitization is important for the increased sensitivity of deep-tissue nociceptors and may, in part, explain hyperalgesia in localised pain conditions. Central sensitization mechanisms (spinal and supraspinal) are also important for the development of hyperalgesia and the pain that is present in more widespread pain conditions. Recent studies have highlighted the contributions of genetic factors to pain sensitivity.
Graven-Nielsen
Thomas
T
Center for Sanse-Motorisk Interaktion, Institut for Sundhedsvidenskab og Teknologi, Aalborg Universitet, 9000 Alborg, Denmark. tgn@hst.aau.dk
Arendt-Nielsen
Lars
L
Madeleine
Pascal
P
Svensson
Peter
P
D000818:Animals; D002908:Chronic Disease; D020022:Genetic Predisposition to Disease; D006801:Humans; D006930:Hyperalgesia / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000235:genetics / Q000503:physiopathology*; D010147:Pain Measurement