[Application of chosen granulocyte markers in diagnostics of Leśniowski-Crohn's disease and ulcerative colitis--preliminary research].
About 15% of cases of nonspecific inflammatory bowel diseases are difficult to diagnose based on clinical, radiological and histopatological criteria. In this study we tried to find a biochemical marker helpful in differential diagnostics and assessment of activity of Leśniowski-Crohn's disease and ulcerative colitis. Plasma concentrations of leukocyte elastase and calprotectin (neutrophiles' proteins), eotaxin (eosinophils chemoatractant) and C-reactive protein were measured in 22 patients with Leśniowski-Crohn's disease and 28 patients witch ulcerative colitis. Significantly higher plasma levels of leukocyte elastase and calprotectin in patients witch ulcerative colitis as compared to Leśniowski-Crohn's disease were found. Thus leukocyte elastase and calprotectin can be considered additional markers differentiating these two diseases. Moreover, plasma concentrations of CRP and leukocyte elastase were associated with the clinical activity of Leśniowski-Crohn's disease whereas CRP and calprotectin concentrations were related to the clinical activity of colitis ulcerosa.
Fedak
Danuta
D
Zakład Diagnostyki Katedry Biochemii, Klinicznej Collegium Medicum UJ, Kraków. dfedak@interia.pl
Pawlica
Dorota
D
Ciećko-Michalska
Irena
I
Solnica
Bogdan
B
Mach
Tomasz
T
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis*; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D002097:C-Reactive Protein; D010196:Pancreatic Elastase