title: Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.
abstract: Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8(+) T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3(+) DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8(+) T cells through XCR1.
authors.affiliation: Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yamazaki
authors.forename: Rie
authors.initials: R
authors.lastname: Miyamoto
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Hoshino
authors.forename: Yuri
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Izumi
authors.initials: I
authors.lastname: Sasaki
authors.forename: Masuyoshi
authors.initials: M
authors.lastname: Saito
authors.forename: Hironori
authors.initials: H
authors.lastname: Ishiguchi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hemmi
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Eri
authors.initials: E
authors.lastname: Hamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirashima
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Amakawa
authors.forename: Shirou
authors.initials: S
authors.lastname: Fukuhara
authors.forename: Shosaku
authors.initials: S
authors.lastname: Nomura
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ito
authors.forename: Tsuneyasu
authors.initials: T
authors.lastname: Kaisho
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002460:Cell Line; D019744:Chemokines, C / Q000096:biosynthesis*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D019707:Receptors, Chemokine / Q000096:biosynthesis*; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis*
chemical_list: D016827:CD8 Antigens; D019744:Chemokines, C; D008024:Ligands; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled; C551408:XC chemokine receptor 1, mouse; C092390:XCL1 protein, human; C091671:XCR1 protein, human; C486249:Xcl1 protein, mouse