title: Prevalence and determinants of hyperglycemia in very low birth weight infants: cohort analyses of the NIRTURE study.
abstract: OBJECTIVE
  To investigate the prevalence and determinants of hyperglycemia in the preterm population, as part of the Neonatal Insulin Therapy in Europe (NIRTURE) Trial.
  
  
  METHODS
  We conducted prospective cohort analyses of continuous glucose monitoring data from control infants participating in an international randomized controlled trial. Data were collected from 188 very low birth weight infants (<1500 g).
  
  
  RESULTS
  In the first week of life, 80% of infants had evidence of glucose levels >8 mmol/L, and 32% had glucose levels >10 mmol/L >10% of the time. Independent risk factors for hyperglycemia included increasing prematurity, small size at birth, use of inotropes, lipid infusions, and sepsis. There was a lack of association between rate of dextrose infused and risk of hyperglycemia.
  
  
  CONCLUSIONS
  The prevalence of hyperglycemia in the very low birth weight infant is high, with marked variability in prevalence between infants, not simply related to rates of glucose infused, but to other potentially modifiable risk factors.
authors.affiliation: Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital NHS Trust, Cambridge, UK. kb274@cam.ac.uk
authors.forename: Kathryn
authors.initials: K
authors.lastname: Beardsall
authors.forename: Sophie
authors.initials: S
authors.lastname: Vanhaesebrouck
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Ogilvy-Stuart
authors.forename: Christine
authors.initials: C
authors.lastname: Vanhole
authors.forename: Chris R
authors.initials: CR
authors.lastname: Palmer
authors.forename: Ken
authors.initials: K
authors.lastname: Ong
authors.forename: Mirjam
authors.initials: M
authors.lastname: vanWeissenbruch
authors.forename: Paula
authors.initials: P
authors.lastname: Midgley
authors.forename: Mike
authors.initials: M
authors.lastname: Thompson
authors.forename: Marta
authors.initials: M
authors.lastname: Thio
authors.forename: Luc
authors.initials: L
authors.lastname: Cornette
authors.forename: Iviano
authors.initials: I
authors.lastname: Ossuetta
authors.forename: Isabel
authors.initials: I
authors.lastname: Iglesias
authors.forename: Claire
authors.initials: C
authors.lastname: Theyskens
authors.forename: Miranda
authors.initials: M
authors.lastname: de Jong
authors.forename: Bryan
authors.initials: B
authors.lastname: Gill
authors.forename: Jag S
authors.initials: JS
authors.lastname: Ahluwalia
authors.forename: Francis
authors.initials: F
authors.lastname: de Zegher
authors.forename: David B
authors.initials: DB
authors.lastname: Dunger
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D019102:Infant, Very Low Birth Weight; D008297:Male; D015337:Multicenter Studies as Topic; D015995:Prevalence; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic