Hydrogels as a platform for stem cell delivery to the heart.
Stem cell therapy offers great promise to repair the injured or failing heart. The outcomes of clinical trials to date, however, have shown that the actual benefit realized falls far short of the promise. A number of factors may explain why that is the case, but poor stem cell retention and engraftment in the hostile environment of the injured heart would seem to be a major factor. Improving stem cell retention and longevity once delivered would seem a logical means to enhance their reparative function. One way to accomplish this goal may be injectable hydrogels, which would serve to fix stem cells in place while providing a sheltering environment. Hydrogels also provide a means to allow for the paracrine factors produced by encapsulated stem cells to diffuse into the injured myocardium. Alternatively, hydrogels themselves can be used for the sustained delivery of reparative factors. Here the authors discuss chitosan-based hydrogels.
Kurdi
Mazen
M
Department of Chemistry and Biochemistry, Faculty of Sciences, The Lebanese University, Rafic Hariri Educational Campus, Hadath, Lebanon.
Chidiac
Rony
R
Hoemann
Caroline
C
Zouein
Fouad
F
Zgheib
Carlos
C
Booz
Georgew W
GW
D006321:Heart; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000379:methods*; D054457:Tissue Scaffolds; D042461:Vascular Endothelial Growth Factor A
D020100:Hydrogels; D042461:Vascular Endothelial Growth Factor A