title: Vitamin E triggers poly(2-hydroxyethyl methacrylate) (PHEMA) embolic potential: a proposed application for endovascular surgery.
abstract: Poly(2-hydroxyethyl methacrylate) (PHEMA) is a biocompatible polymer used as embolizing agent for endovascular surgery. Blending of PHEMA with a hydrophobic and anti-oxidant agent, Vitamin E (Vit.E, 0.1-10%, w/v), modified PHEMA's haemocombatibility, evaluated measuring wettability, plasma protein adsorption along with whole blood coagulation time. The presence of Vit.E increases PHEMA's hydrophobicity and plasma protein adsorption (in particular albumin and Immunoglobulin G), while it also accelerates blood clot formation. These effects are developed due to a combination of issues such as surface hydrophobicity and plasma protein adsorption induced by the presence of Vit.E, suggesting that Vit.E blending could improve the use of PHEMA as embolizing agent.
authors.affiliation: Research Centre for Biocompatibility and Tissue Engineering, Clinical and Experimental Medicine Department, University of Eastern Piedmont A. Avogadro, Via Solaroli 17, 28100 Novara, Italy. filippo.reno@med.unipmn.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Renò
authors.forename: Vincenzina
authors.initials: V
authors.lastname: Traina
authors.forename: Silvia
authors.initials: S
authors.lastname: Gatti
authors.forename: Mario
authors.initials: M
authors.lastname: Cannas
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008422:Materials Testing; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012307:Risk Factors; D014656:Vascular Surgical Procedures / Q000379:methods*; D014810:Vitamin E / Q000737:chemistry*; D017155:Wettability
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D011108:Polymers; D014810:Vitamin E; D011102:Polyhydroxyethyl Methacrylate