title: [Progress on Sp1-like and Krüppel-like factors].
abstract: Sp1-like and Krüppel-like factors (Sp1/KLFs) are a family of zinc-finger proteins that are important components of transcriptional machinery in eukaryotic cells. Sp1/KLFs have highly conserved DNA binding domains at the carboxyl terminus that have three tandem zinc-finger motifs. Their amino terminal regions vary greatly and contain transcription regulatory domains that interact with co-regulators. By regulating the expression of a large number of genes containing GC-rich or CACCC promoters in a tissue-, cell- and developmental stage-specific manner, Sp1/KLFs may be involved in many biological processes, including cell proliferation, differentiation, apoptosis and neoplastic transformation. In this article, we reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs.
authors.affiliation: Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China. xiongq@big.ac.cn
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiong
authors.forename: Xiu-Yan
authors.initials: XY
authors.lastname: Ruan
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Fang
mesh_terms: D000818:Animals; D002453:Cell Cycle; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology; D016329:Sp1 Transcription Factor / Q000737:chemistry / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology
chemical_list: D051741:Kruppel-Like Transcription Factors; D016329:Sp1 Transcription Factor