title: Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest.
abstract: Although epithelial to mesenchymal transitions (EMT) are often viewed as a unique event, they are characterized by a great diversity of cellular processes resulting in strikingly different outcomes. They may be complete or partial, massive or progressive, and lead to the complete disruption of the epithelium or leave it intact. Although the molecular and cellular mechanisms of EMT are being elucidated owing chiefly from studies on transformed epithelial cell lines cultured in vitro or from cancer cells, the basis of the diversity of EMT processes remains poorly understood. Clues can be collected from EMT occuring during embryonic development and which affect equally tissues of ectodermal, endodermal or mesodermal origins. Here, based on our current knowledge of the diversity of processes underlying EMT of neural crest cells in the vertebrate embryo, we propose that the time course and extent of EMT do not depend merely on the identity of the EMT transcriptional regulators and their cellular effectors but rather on the combination of molecular players recruited and on the possible coordination of EMT with other cellular processes.
authors.affiliation: CNRS, Laboratoire de Biologie du Développement, Paris, France. jean-loup.duband@upmc.fr
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Duband
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D002645:Chickens; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D053263:Gene Regulatory Networks / Q000235:genetics; D009432:Neural Crest / Q000166:cytology* / Q000378:metabolism*; D054261:Neurulation / Q000235:genetics; D014158:Transcription, Genetic