title: Prevalence of asymptomatic bacteriuria in type 2 diabetic subjects with and without microalbuminuria.
abstract: BACKGROUND
  Diabetic subjects, especially women, show high prevalence of asymptomatic bacteriuria (ASB). The aim of the present study was to evaluate the prevalence of ASB in subjects with type 2 diabetes mellitus (T2D) with and without microalbuminuria (MA).
  
  
  RESULTS
  A hundred diabetic subjects with MA (53 males/47 females, mean age +/- standard deviation: 65.5 +/- 11.1 years) and 100 diabetic subjects without MA (52 males/48 females, mean age +/- standard deviation: 65.4 +/- 11.3 years), consecutively attending the outpatient diabetes clinic of our hospital were recruited in the study. Subjects with overt diabetic nephropathy or nephropathy from other causes were excluded. In addition, subjects with symptoms of urinary track infection or use of antimicrobial drugs in the last 14 days were excluded by the study.Diabetic subjects with MA showed increased prevalence of ASB compared to diabetic subjects without MA (21% versus 8%, P < 0.001, respectively). Escherichia coli was the most prevalent pathogen isolated in diabetic subjects with and without MA (12% versus 3.0%, P = 0.01, respectively) followed by Proteus mirabilis (6% versus 5%, P = 0.75, respectively) and Klebsiella spp (5% versus 1%, P = 0.09, respectively). Univariate logistic analysis showed that ASB was associated with the presence of coronary artery disease [odds ratio (OR): 0.29, 95% Confidence Intervals (95% CI): 0.09-0.95, P = 0.04] and gender (OR: 0.09, 95% CI: 0.02-0.35, P < 0.001) in the diabetic study group with MA.
  
  
  CONCLUSIONS
  ASB is more prevalent among T2D subjects with MA. Screening for ASB is warranted in diabetic patients especially if pyuria is detected in urine analysis since ASB has been found to be a risk factor for developing symptomatic urinary tract infection.
authors.affiliation: 3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia "Ag, Panteleimon" - Piraeus, Greece. pathan@ath.forthnet.gr.
authors.forename: Athanasia
authors.initials: A
authors.lastname: Papazafiropoulou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Daniil
authors.forename: Alexios
authors.initials: A
authors.lastname: Sotiropoulos
authors.forename: Eleni
authors.initials: E
authors.lastname: Balampani
authors.forename: Anthi
authors.initials: A
authors.lastname: Kokolaki
authors.forename: Stavros
authors.initials: S
authors.lastname: Bousboulas
authors.forename: Stavroula
authors.initials: S
authors.lastname: Konstantopoulou
authors.forename: Eystathios
authors.initials: E
authors.lastname: Skliros
authors.forename: Dimitra
authors.initials: D
authors.lastname: Petropoulou
authors.forename: Stavros
authors.initials: S
authors.lastname: Pappas