miRNAs as biomarkers in colorectal cancer diagnosis and prognosis.
Since the discovery of noncoding small miRNAs and their function in controlling mRNA translational rate, the small non-coding miRNA world has become a research wonderland for cancer and other human diseases. Due to the critical regulatory function, miRNA can act as an oncogene or a tumor-suppressor gene. This review will cover some of the recent discoveries of the potential of miRNAs as cancer biomarkers in colorectal cancer, future challenges and solutions.
Ju
Jingfang
J
Translational Research Laboratory, Department of Pathology, Stony Brook University Medical Center, State University of New York-Stony Brook, Stony Brook, NY 11794-8691, USA. jiju@notes.cc.sunysb.edu
D000818:Animals; D014408:Biomarkers, Tumor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D020871:RNA Stability
D014408:Biomarkers, Tumor; D035683:MicroRNAs