A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.
A bis(thiosemicarbazonato)copper(ii) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.
Lim
Sinchun
S
School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia 3010.
Paterson
Brett M
BM
Fodero-Tavoletti
Michelle T
MT
O'Keefe
Graeme J
GJ
Cappai
Roberto
R
Barnham
Kevin J
KJ
Villemagne
Victor L
VL
Donnelly
Paul S
PS
D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D003301:Copper Radioisotopes / Q000737:chemistry; D006801:Humans; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry; D013882:Thiosemicarbazones / Q000737:chemistry
D016229:Amyloid beta-Peptides; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013267:Stilbenes; D013882:Thiosemicarbazones