Two new triterpenoids from the roots of Actinidia chinensis.
Two new triterpenoids (1, 2), together with one flavonoid glycoside and thirteen known triterpenoids were isolated from the roots of Actinidia chinensis Planch (Actinidiaceae). The structures of the new constituents were elucidated as 12α-chloro-2α, 3β, 13β, 23-tetrahydroxyolean-28-oic acid-13-lactone (1), 2α, 3α, 19α, 23, 24-pentahydroxyurs-12-en-28-oic acid (2). Structure elucidation was accomplished by 1D, 2D NMR spectra (HMQC, HMBC, (1)H-(1)H COSY, TOCSY, and NOESY) and mass spectrometry (ESIMS). Moreover, two known triterpenoids showed positive cytotoxic activity against LOVO and HepG2 cell lines.
Xu
Yi-Xin
YX
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Xiang
Zhao-Bao
ZB
Jin
Yong-Sheng
YS
Shen
Yang
Y
Chen
Hai-Sheng
HS
D029042:Actinidia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C557760:12alpha-chloro-2alpha,3beta,13beta,23-tetrahydroxyolean-28-oic acid-13-lactone; C557761:2alpha,3beta,13beta,23,24-pentahydroxyurs-12-en-28-oic acid; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes