title: Effect of oral itraconazole on the pharmacokinetics of tacrolimus in a hematopoietic stem cell transplant recipient with CYP3A5*3/*3.
authors.forename: Miho
authors.initials: M
authors.lastname: Nara
authors.forename: Naoto
authors.initials: N
authors.lastname: Takahashi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Miura
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Saitoh
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kagaya
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sawada
mesh_terms: D000284:Administration, Oral; D000483:Alleles; D000935:Antifungal Agents / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D002214:Capsules; D003131:Combined Modality Therapy; D051544:Cytochrome P-450 CYP3A / Q000235:genetics / Q000378:metabolism; D065692:Cytochrome P-450 CYP3A Inhibitors; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000517:prevention & control; D006207:Half-Life; D006689:Hodgkin Disease / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007262:Infusions, Intravenous; D007422:Intestines / Q000201:enzymology; D017964:Itraconazole / Q000494:pharmacology*; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D016559:Tacrolimus / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014184:Transplantation, Homologous; D014747:Vinblastine / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D002214:Capsules; D065692:Cytochrome P-450 CYP3A Inhibitors; D007166:Immunosuppressive Agents; D001761:Bleomycin; D017964:Itraconazole; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; C510164:CYP3A5 protein, human; D051544:Cytochrome P-450 CYP3A; D016559:Tacrolimus; D008727:Methotrexate