title: [Diagnosing silent cardiac dysautonomia via ambulatory blood pressure monitoring: early diagnosis shown by the lack of heart rate circadian rhythm in type 1 diabetes mellitus].
abstract: BACKGROUND
  Diabetes mellitus (DM) can be complicated by an involvement of Neurovegetative System (NVS), conventionally and non-invasively diagnosed by the means of Ewing's test and Heart Rate Variability (HRV) analysis. It is well known that the NVS is physiologically responsible, via biological clocks, for the regulation of Circadian Rhythms (CR) characterizing the majority of biological functions. Therefore, this study is aimed at investigating the CR of Heart Rate (HR) and Blood Pressure (BP) in DM, postulating that the diagnosis of Silent Cardiac Dysautonomia (SCD) could be facilitated by detecting anomalous rhythmometric changes, including the worse one, i.e., the lose of a CR.
  
  
  METHODS
  The study has been performed on 30 clinically healthy subjects (CHS), 10 patients with DM1 and 30 patients with DM2, who underwent an ambulatory BP monitoring (ABPM) collecting data equidistantly every 30 minutes, under standardized conditions of lifestyle. The group specific monitored values of systolic (S), diastolic (D) BP, as well as HR have been analyzed via: 1. a conventional analysis of their intradiem variability; 2. a chronobiometric analysis (Cosinor method) of their CR.
  
  
  RESULTS
  The conventional analysis disclosed that in CHS, DM1 and DM2, both the HR and BP show an intradiem variability that is significant (p less than 0.001). The chronobiological analysis showed that in CHS and DM2, both the HR and BP show a significant CR (p less than 0.001), viceversa in DM1 HR is characterized by a non significant CR (p=0.124), notwithstanding that the SBP and DBP maintain a significant CR (p less than 0.001).
  
  
  CONCLUSIONS
  The disappearance of HR CR in DM1 reveals the involvement of neurovegetative biological clock that selectively controls the HR CR, as it is demonstrated by the pathophysiological finding of an internal desynchronization between the HR and BP CR. The selective lose of HR CR in DM1 leads to conclude that the ABPM, along with its Cosinor analysis, might be a practical, repeatable, low cost, low risk technique for diagnosing the SCD, at least in DM1.
authors.affiliation: Dipartimento di Scienze Cliniche, Università "Sapienza", Roma, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Cugini
authors.forename: S
authors.initials: S
authors.lastname: Amato
authors.forename: G
authors.initials: G
authors.lastname: Tarquini
authors.forename: S
authors.initials: S
authors.lastname: Mercuri
authors.forename: I
authors.initials: I
authors.lastname: Turinese
authors.forename: A
authors.initials: A
authors.lastname: Tego
authors.forename: M
authors.initials: M
authors.lastname: Rossetti
authors.forename: D
authors.initials: D
authors.lastname: Panetti
authors.forename: T
authors.initials: T
authors.lastname: Filardi
authors.forename: M
authors.initials: M
authors.lastname: Curione
authors.forename: S
authors.initials: S
authors.lastname: Morano
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D042241:Early Diagnosis; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000209:etiology; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D054969:Primary Dysautonomias / Q000175:diagnosis* / Q000209:etiology; D055815:Young Adult