title: Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway.
abstract: Ansellone A (1) has been isolated from the dorid nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It has the new "ansellane" sesterterpenoid carbon skeleton, and it activates the cAMP signaling pathway.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: Julie
authors.initials: J
authors.lastname: Daoust
authors.forename: Angelo
authors.initials: A
authors.lastname: Fontana
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Merchant
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kieffer
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D049851:Gastropoda / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D054830:Sesterterpenes; C552584:ansellone A; D000242:Cyclic AMP