Study on syntheses and anticoagulant action of heparin/rare earth nano-oxides hybrid material.
Four hybrid materials of RE2O3-TDI-Heparin (TDI=Toluene 2,4-diisocyanate, RE=La, Eu, Nd, Sc) were prepared by the method of graft. The materials were characterized by IR, TG, and SEM, which confirmed that the heparin was grafted on the surface of TDI modified rare earth nano-oxides. The cell adhesion experiment and the anticoagulant experiment demonstrated that the materials have lower cell toxicity, better cell adhesion as well as better anticoagulant action. In addition, the clotting time of hybrid materials were shortened compared with the heparin.
Wang
Kun-Jie
KJ
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Li
Hong-Xia
HX
Song
Yu-Min
YM
Luan
Ni-Na
NN
Xian
Ping
P
D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002113:Calcification, Physiologic / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D006493:Heparin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008674:Metals, Rare Earth / Q000737:chemistry / Q000494:pharmacology*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016716:PC12 Cells; D011817:Rabbits; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013997:Time Factors
D000925:Anticoagulants; D008674:Metals, Rare Earth; D010087:Oxides; D006493:Heparin