[General survey of mechanisms of acrylamide neurotoxicity].
Acrylamide (ACR) is widespread in working and living environments. Neurotoxicities of persons and animals exposed to acrylamide were confirmed by former studies. Recently, the mechanisms of neurotoxicity induced by acrylamide, such as formation of adduct, abnormality of the energy metabolism, injury of the axoplasmic transport, and injury of the nerve terminal and apoptosis were more centered. In this review, its mechanisms were discussed.
Guo
Canlan
C
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China. guocanlan@163.com
Li
Bin
B
Xiao
Jingwei
J
D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001370:Axonal Transport / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D020106:Acrylamide