[Hypertension as a biological marker of systemic atherosclerotic disease].
There is a close link between hypertension and atherosderosis. Hypertension causes atherosclerotic damage of several organs, called target organs and the risk factors for hypertension and atherosderosis are very similar. The risk of mortality associated to hypertension increases with blood pressure values below the cutoff point of normality (140/90 mm Hg), even below 130/85 mm Hg, and includes a stage called pre hypertension. Moreover, the initial damage of the arterial walls and target organs are present before there is a significant elevation of blood pressure. Therefore, hypertension could become a biological marker of the evolution of an underlying atherosclerotic process. A new pathophysiological paradigm has been proposed in which the severity of hypertension is not classified according to blood pressure values, but rather on the initiation and progression of vascular damage among target organs. These alterations determine the prognosis and management of systemic vascular damage that can be called "hypertensive atherosclerotic disease" or simply systemic atherosclerotic disease.
Román A
Oscar
O
Servicio Cardiovascular, Hospital San Borja-Arriarán, Santiago de Chile. oscarromanalemany@hotmail.com
Badilla S
Marta
M
Dussaubat A
Ana María
AM
D050197:Atherosclerosis / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors
D015415:Biomarkers