title: Telomere length and genetic analyses in population-based studies of endometrial cancer risk.
abstract: BACKGROUND
  Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic.
  
  
  METHODS
  The authors used conditional logistic regression to examine relative telomere length in peripheral blood leukocytes, genetic variants at telomere maintenance gene loci (TERT, TNKS2, POT1, TERF1, TERF2), and endometrial cancer risk in case-control studies nested within the Nurses' Health Study and the Women's Health Study.
  
  
  RESULTS
  Relative telomere length was significantly inversely correlated with body mass index and weight gain since age 18 years. The authors did not observe a relationship between relative telomere length and endometrial cancer risk. Women in the shortest quartile had a multivariate-adjusted odds ratio (OR) of 1.20 (95% confidence interval [95% CI], 0.73-1.96; P for trend = .37) compared with women in the longest quartile. The authors found an elevation in endometrial cancer risk among women carrying at least 1 minor allele of RS2736122 (TERT; OR, 1.18; 95% CI, 1.01-1.38) or RS12412538 (TNKS2; OR, 1.16; 95% CI, 1.00-1.34).
  
  
  CONCLUSIONS
  Relative telomere length was not associated with endometrial cancer risk. Other aspects of telomere maintenance remain to be explored.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Prescott
authors.forename: Monica
authors.initials: M
authors.lastname: McGrath
authors.forename: I-Min
authors.initials: IM
authors.lastname: Lee
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.forename: Immaculata
authors.initials: I
authors.lastname: De Vivo
mesh_terms: D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D012306:Risk; D016615:Telomere / Q000648:ultrastructure*