title: Copper-catalyzed intramolecular C-H oxidation/acylation of formyl-N-arylformamides leading to indoline-2,3-diones.
abstract: A new, efficient Cu-catalyzed intramolecular C-H oxidation/acylation method has been developed for the synthesis of substituted indoline-2,3-diones (isatins). In the presence of CuCl(2) and O(2), a variety of formyl-N-arylformamides underwent the tandem reaction to afford the corresponding indoline-2,3-diones in moderate to good yields. It is noteworthy that the reaction serves as the first example of transition-metal-catalyzed transformation for the preparation of indoline-2,3-diones.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China.
authors.forename: Bo-Xiao
authors.initials: BX
authors.lastname: Tang
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Cui-Yan
authors.initials: CY
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Zhou
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Wei
authors.forename: Guo-Bo
authors.initials: GB
authors.lastname: Deng
authors.forename: Du-Lin
authors.initials: DL
authors.lastname: Yin
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D000215:Acylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005559:Formamides / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D005559:Formamides; D007211:Indoles; D002244:Carbon; D003300:Copper; D006859:Hydrogen