CD56-positive diffuse large B-cell lymphoma: possible association with extranodal involvement and bcl-6 expression.
Among B-cell non-Hodgkin's lymphomas, neural cell adhesion molecule/CD56 expression is exceptional. In this study, seven cases of CD56-positive diffuse large B-cell lymphoma (DLBCL) are described. The frequency of CD56-positive DLBCL was 7% in our hospital. Four of seven (57.1%) cases expressed both CD10 and bcl-6 suggestive of a germinal center B-cell phenotype. Six of seven (85.7%) cases expressed bcl-6. Two cases expressed aberrant T cell-associated antigens, one each of CD7 and CD8. However, none of these seven cases showed CD5 expression. No significant difference was observed between CD56-positive and CD56-negative DLBCL in terms of the five international prognostic index risk factors. However, all seven cases had at least one extranodal involvement and showed a good response to initial treatment. The predominance of extranodal involvement in our series may be associated with the adhesion-related function of CD56. A high frequency of bcl-6 expression may be associated with a more favorable clinical course and prognosis.
Gomyo
Hiroshi
H
Hematology Division, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kajimoto
Kazuyoshi
K
Miyata
Yoshiharu
Y
Maeda
Akio
A
Mizuno
Ishikazu
I
Yamamoto
Katsuya
K
Obayashi
Chiho
C
Hanioka
Keisuke
K
Murayama
Tohru
T
D000328:Adult; D019002:CD56 Antigen / Q000096:biosynthesis* / Q000276:immunology; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D051560:Proto-Oncogene Proteins c-bcl-6; D012189:Retrospective Studies; D055815:Young Adult
C084103:BCL6 protein, human; D019002:CD56 Antigen; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6