Tumour-associated carbohydrate antigens in breast cancer.
Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed.
Cazet
Aurélie
A
Structural and Functional Glycobiology Unit, UMR CNRS 8576, University of Sciences and Technologies of Lille, Villeneuve d'Ascq, France. aurelie_cazet@yahoo.fr
Julien
Sylvain
S
Bobowski
Marie
M
Burchell
Joy
J
Delannoy
Philippe
P
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D011379:Prognosis
D015295:Antigens, Tumor-Associated, Carbohydrate