title: Primary large-cell neuroendocrine carcinoma of the scrotum.
abstract: Neuroendocrine tumors (NETs) mostly develop from the neural crest cells but a few arise from neuroectoderm. They are common in the lungs and gastrointestinal tract but rare in the genitourinary tract. A 78-year-old man with no family history of malignant or hereditary diseases presented with a 3-month history of a rapidly growing asymptomatic scrotal nodule and swelling in the groin. He had a negative history of sexually transmitted disease and of trauma, fungal infection or chronic irritation in the scrotal area; there was no history of radiotherapy or exposure to chemicals or arsenic. Both the scrotal and groin lesions were excised with a minimum of 1.2 cm of normal skin. Examination of the specimen revealed a confined poorly differentiated large-cell neuroendocrine carcinoma with a metastasis to the inguinal lymph nodes. Three months after the excision we found a local recurrence. The recurrent tumor revealed tumor tissue concurrent with the primary lesion. To the best of our knowledge, there have been no previously published case reports on neuroendocrine tumor of the scrotum.
authors.affiliation: Department of Urology, Clinical Hospital Center Rijeka, Rijeka, Croatia.
authors.forename: Anton
authors.initials: A
authors.lastname: Maricić
authors.forename: Miljenko
authors.initials: M
authors.lastname: Katunarić
authors.forename: Nikica
authors.initials: N
authors.lastname: Sutalo
authors.forename: Snjezana
authors.initials: S
authors.lastname: Tomic
authors.forename: Davor
authors.initials: D
authors.lastname: Jurisic
authors.forename: Marija
authors.initials: M
authors.lastname: Petkovic
authors.forename: Gordana
authors.initials: G
authors.lastname: Zamolo
mesh_terms: D000368:Aged; D018287:Carcinoma, Large Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005834:Genital Neoplasms, Male / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009919:Orchiectomy; D012086:Reoperation; D012611:Scrotum / Q000473:pathology / Q000601:surgery; D013737:Testis / Q000473:pathology