title: Water-soluble fluorescent conjugated polymers and their interactions with biomacromolecules for sensitive biosensors.
abstract: Over the past decades, water-soluble conjugated polymers (CPs) have gained increasing attention as optical platforms for sensitive detection of biomacromolecules (DNA, protein and cell) due to the amplification of fluorescent signals. To meet the requirement for high throughput assays, chip and microarray techniques based on CPs have also been developed. Very recently, fluorescence imaging in vivo and at the cellular level have also been successfully accomplished using these water-soluble CPs. In this tutorial review, we provide a brief review of the synthesis and optical properties of CPs, focusing especially on their applications in biosensors and cell imaging.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, 100190, Beijing, P.R. China.
authors.forename: Xuli
authors.initials: X
authors.lastname: Feng
authors.forename: Libing
authors.initials: L
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Daoben
authors.initials: D
authors.lastname: Zhu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004966:Estrogens, Conjugated (USP) / Q000528:radiation effects; D005456:Fluorescent Dyes; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D004966:Estrogens, Conjugated (USP); D005456:Fluorescent Dyes; D011108:Polymers; D014867:Water