title: Network analysis of hepatic genes responded to high-fat diet in C57BL/6J mice: nutrigenomics data mining from recent research findings.
abstract: Obesity and its associated complications, including diabetes, dyslipidemia, atherosclerosis, and some cancers, have been a global health problem with a rapid increase of the obese population. In this study, we selected 31 obesity candidate genes in the liver of high-fat-induced obese C57BL/6J mice through investigation of literature search and analyzed functional protein-protein interaction of the genes using the STRING database. Most of the obesity candidate genes were closely connected through lipid metabolism, and in particular acyl-coenzyme A oxidase 1 appeared to be a core obesity gene. Overall, genes involved in fatty acid beta-oxidation, fatty acid synthesis, and gluconeogenesis were up-regulated, and genes involved in sterol biosynthesis, insulin signaling, and oxidative stress defense system were down-regulated with a high-fat diet. Future identification of core obesity genes and their functional targets is expected to provide a new way to prevent obesity by phytochemicals or functional foods on the basis of food and nutritional genomics.
authors.affiliation: Department of Food Science and Nutrition, Food and Nutritional Genomics Research Center, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Eunjung
authors.initials: E
authors.lastname: Kim
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kwon
authors.forename: Hyun-Seo
authors.initials: HS
authors.lastname: Jang
authors.forename: Cheol-Goo
authors.initials: CG
authors.lastname: Hur
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000818:Animals; D057225:Data Mining; D030562:Databases, Protein; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D054647:Nutrigenomics; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004041:Dietary Fats