title: A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease.
abstract: Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic cause for Parkinson's disease (PD). MitoQ is a powerful mitochondrial antioxidant. It is absorbed orally and concentrates within mitochondria where it has been shown to protect against oxidative damage. We enrolled 128 newly diagnosed untreated patients with PD in a double-blind study of two doses of MitoQ compared with placebo to explore the hypothesis that, over 12 months, MitoQ would slow the progression of PD as measured by clinical scores, particularly the Unified Parkinson Disease Rating Scale. We showed no difference between MitoQ and placebo on any measure of PD progression. MitoQ does not slow the progression of PD, and this finding should be taken into account when considering the oxidative stress hypothesis for the pathogenesis of PD.
authors.affiliation: Neurology Department, Auckland Hospital, Auckland, New Zealand. bsnow@adhb.govt.nz
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Snow
authors.forename: Fiona L
authors.initials: FL
authors.lastname: Rolfe
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Lockhart
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Frampton
authors.forename: John D
authors.initials: JD
authors.lastname: O'Sullivan
authors.forename: Victor
authors.initials: V
authors.lastname: Fung
authors.forename: Robin A J
authors.initials: RA
authors.lastname: Smith
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D009943:Organophosphorus Compounds; D014451:Ubiquinone; C429014:mitoquinone