title: Myasthenia and related disorders of the neuromuscular junction.
abstract: Our understanding of transmission at the neuromuscular junction has increased greatly in recent years. We now recognise a wide variety of autoimmune and genetic diseases that affect this specialised synapse, causing muscle weakness and fatigue. These disorders greatly affect quality of life and rarely can be fatal. Myasthenia gravis is the most common disorder and is most commonly caused by autoantibodies targeting postsynaptic acetylcholine receptors. Antibodies to muscle-specific kinase (MuSK) are detected in a variable proportion of the remainder. Treatment is symptomatic and immunomodulatory. Lambert-Eaton myasthenic syndrome is caused by antibodies to presynaptic calcium channels, and approximately 50% of cases are paraneoplastic, most often related to small cell carcinoma of the lung. Botulism is an acquired disorder caused by neurotoxins produced by Clostridium botulinum, impairing acetylcholine release into the synaptic cleft. In addition, several rare congenital myasthenic syndromes have been identified, caused by inherited defects in presynaptic, synaptic basal lamina and postsynaptic proteins necessary for neuromuscular transmission. This review focuses on recent advances in the diagnosis and treatment of these disorders.
authors.affiliation: UCL Institute of Neurology, Queen Square, London, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Spillane
authors.forename: David J
authors.initials: DJ
authors.lastname: Beeson
authors.forename: Dimitri M
authors.initials: DM
authors.lastname: Kullmann
mesh_terms: D001906:Botulism / Q000473:pathology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015624:Lambert-Eaton Myasthenic Syndrome / Q000473:pathology / Q000628:therapy; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D020294:Myasthenic Syndromes, Congenital / Q000473:pathology / Q000628:therapy; D009431:Neural Conduction / Q000502:physiology; D009469:Neuromuscular Junction / Q000473:pathology*; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000276:immunology / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases