title: Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.
abstract: The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.
authors.affiliation: Institut de Biologia Molecular de Barcelona, Parc Cientific de Barcelona, Barcelona, Spain.
authors.forename: Nereida
authors.initials: N
authors.lastname: Jiménez-Menéndez
authors.forename: Pablo
authors.initials: P
authors.lastname: Fernández-Millán
authors.forename: Anna
authors.initials: A
authors.lastname: Rubio-Cosials
authors.forename: Carme
authors.initials: C
authors.lastname: Arnan
authors.forename: Julio
authors.initials: J
authors.lastname: Montoya
authors.forename: Howard T
authors.initials: HT
authors.lastname: Jacobs
authors.forename: Pau
authors.initials: P
authors.lastname: Bernadó
authors.forename: Miquel
authors.initials: M
authors.lastname: Coll
authors.forename: Isabel
authors.initials: I
authors.lastname: Usón
authors.forename: Maria
authors.initials: M
authors.lastname: Solà
mesh_terms: D050976:Basic-Leucine Zipper Transcription Factors / Q000737:chemistry* / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D024101:Mitochondrial Proteins; D008958:Models, Molecular; D011487:Protein Conformation; D020080:Tandem Repeat Sequences
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D004272:DNA, Mitochondrial; C105178:MTERF1 protein, human; D024101:Mitochondrial Proteins; D004247:DNA