title: A phase 1-2 study of imexon plus dacarbazine in patients with unresectable metastatic melanoma.
abstract: BACKGROUND
  Imexon (Amplimexon) is an aziridine compound that increases reactive oxygen species, disrupts mitochondrial membranes, and induces apoptosis. Preclinical studies showed activity against melanoma cell lines and models in mice, and synergy with dacarbazine. The authors evaluated standard doses of dacarbazine combined with increasing doses of imexon to determine the maximal tolerated dose (MTD), toxicities, pharmacokinetics, and efficacy.
  
  
  METHODS
  Sixty-eight chemotherapy-naive melanoma patients (1 inoperable stage III and 67 stage IV) were treated with dacarbazine (250 mg/m2) and imexon (570-1300 mg/m2), both daily for 5 days every 3 weeks.
  
  
  RESULTS
  There were 18 patients in the phase 1, and 50 in the phase 2 component of the study. The MTD of imexon with dacarbazine was 1000 mg/m2. Dose-limiting toxicities were pulmonary edema and hepatorenal failure. At the MTD, therapy was well tolerated. The most common toxicities (any grade) were vomiting, diarrhea, anemia, thrombocytopenia, anorexia, fever, and constipation. Among 68 patients, there were 7 treatment-related serious adverse events. Partial response and stable disease rates were 5.9% and 25% for all subjects and 2% and 30% for the phase 2 patients, respectively. Median progression-free and overall survival of all patients were 2.0 and 11.7 months and 2 and 7.5 months for the phase 2 patients, respectively. Overall survival of the 31 patients with normal lactate dehydrogenase levels was >22.5 months. Pharmacokinetics of both drugs were similar to previous reports.
  
  
  CONCLUSIONS
  Imexon plus dacarbazine was well tolerated. The survival data suggest further evaluation in a randomized phase 2 study.
authors.affiliation: Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA. Jeffrey.weber@moffitt.org
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Weber
authors.forename: Wolfram E
authors.initials: WE
authors.lastname: Samlowski
authors.forename: Rene
authors.initials: R
authors.lastname: Gonzalez
authors.forename: Antoni
authors.initials: A
authors.lastname: Ribas
authors.forename: Joe
authors.initials: J
authors.lastname: Stephenson
authors.forename: Steven
authors.initials: S
authors.lastname: O'Day
authors.forename: Takami
authors.initials: T
authors.lastname: Sato
authors.forename: Robert
authors.initials: R
authors.lastname: Dorr
authors.forename: Kathryn
authors.initials: K
authors.lastname: Grenier
authors.forename: Evan
authors.initials: E
authors.lastname: Hersh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003606:Dacarbazine / Q000008:administration & dosage*; D005260:Female; D006588:Hexanones / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D020714:Maximum Tolerated Dose; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D006588:Hexanones; C014919:4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one; D003606:Dacarbazine