Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.
Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes.
Karunasena
Enusha
E
Department of Animal & Food Sciences, Texas Tech University, Lubbock, TX 79409, USA. enusha.karunasena@ttuhsc.edu
Larrañaga
Michael D
MD
Simoni
Jan S
JS
Douglas
David R
DR
Straus
David C
DC
D017209:Apoptosis; D001253:Astrocytes / Q000187:drug effects*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects*; D006801:Humans; D058953:Neural Stem Cells / Q000187:drug effects*; D013312:Stress, Physiological; D014255:Trichothecenes / Q000633:toxicity*
D014255:Trichothecenes; C014184:satratoxin H