Metastasectomy for stage IV colorectal cancer.
Metastatic colorectal cancer traditionally has been considered incurable. Over the past 3 decades, however, resection of low-volume hepatic disease has been recognized as beneficial in some cases. More recently, resection of isolated pulmonary metastases has been shown to offer long-term survival in carefully selected patients. Resection of metastases to more unusual sites (ovary, brain, peritoneal cavity) is more controversial; nevertheless, retrospective data suggest that a few patients may be cured with resection of these tumors. In this article, we review the history and current status of metastasectomy in stage IV colorectal cancer.
Mahmoud
Najjia
N
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bullard Dunn
Kelli
K
D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D019635:Neurosurgical Procedures / Q000379:methods; D010051:Ovarian Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D011013:Pneumonectomy / Q000379:methods*; D015996:Survival Rate / Q000639:trends