A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation.
Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.
Park
Jae-Jeong
JJ
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Yun
Sook Jung
SJ
Lee
Jee-Bum
JB
Kim
Seong-Jin
SJ
Won
Young Ho
YH
Lee
Seung-Chul
SC