title: Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population.
abstract: Gestational diabetes mellitus (GDM) and type 2 diabetes (T2D) share common pathophysiological features, including β-cell dysfunction and insulin resistance. In this study, we investigated the association between GDM and five recently identified T2D susceptibility loci, in a Greek population. We studied 148 women with GDM and 107 non-diabetic unrelated pregnant Greek women, for polymorphisms in the TCF7L2 gene (rs7903146 C/T), the PPARG gene (Pro12Ala), the KCNJ11 gene (E23K), the IRS1 gene (G972R) and in the FOXC2 gene (-512C>T). The T-allele of the TCF7L2 rs7903146 (C/T) polymorphism was found to be significantly associated with an increased risk of GDM [p = 0.0003; odds ratio (OR) 2.04 (95%CI 1.38-3.00)]. Additionally, CT and TT genotypes were significantly overrepresented in women with GDM compared to controls (p = 0.0003 and p = 0.0148, respectively). Analysis of the IRS1 G972R polymorphism showed that the R-allele frequency was increased in women with GDM [(p = 0.009; OR 1.67 (95%CI 1.14-2.47)]. The genotypes and allele frequencies of the other polymorphisms studied did not statistically differ between the GDM and the control women. Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
authors.affiliation: First Department of Obstetrics and Gynecology, University of Athens, School of Medicine, Athens, Greece. kpappa@med.uoa.gr
authors.forename: Kalliopi I
authors.initials: KI
authors.lastname: Pappa
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Economou
authors.forename: George
authors.initials: G
authors.lastname: Daskalakis
authors.forename: Eleni
authors.initials: E
authors.lastname: Anastasiou
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Anagnou
authors.forename: Aristides
authors.initials: A
authors.lastname: Antsaklis
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006115:Greece; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D011247:Pregnancy; D011446:Prospective Studies; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics; D055815:Young Adult; D000099161:Kcnj11 Channel
chemical_list: D051858:Forkhead Transcription Factors; D055504:Insulin Receptor Substrate Proteins; D047495:PPAR gamma; D024661:Potassium Channels, Inwardly Rectifying; D058118:Transcription Factor 7-Like 2 Protein; D000099161:Kcnj11 Channel; C526292:IRS1 protein, human; C544894:TCF7L2 protein, human; C082078:mesenchyme fork head 1 protein