title: Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation.
abstract: Allogeneic hemopoietic stem cell transplantation (HSCT) has been considered a curative treatment option for many hematological and non-hematological disorders. Despite the use of advanced methods of tissue typing and new therapies, graft versus host disease (GVHD) remains a major obstacle. Secondary malignancies are also among the most serious long-term complications after HSCT including leukemia, lymphomas, and to a lesser extent, solid tumors. The most commonly observed solid tumor is squamous cell carcinoma (SCC). We report two cases of SCC of the lower lip diagnosed several years after HSCT. Both cases were complicated with GVHD prior to the development of SCC and had a successful outcome with minimal surgical intervention.
authors.affiliation: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. ihamadah@kfshrc.edu.sa
authors.forename: Issam
authors.initials: I
authors.lastname: Hamadah
authors.forename: Yousef
authors.initials: Y
authors.lastname: Binamer
authors.forename: Saad
authors.initials: S
authors.lastname: Alajlan
authors.forename: Amr
authors.initials: A
authors.lastname: Nassar
authors.forename: Abu Jafar M
authors.initials: AJ
authors.lastname: Saleh
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery*; D006086:Graft vs Host Disease / Q000473:pathology / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology / Q000628:therapy; D008048:Lip Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009101:Multiple Myeloma / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery*; D014184:Transplantation, Homologous