title: Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups.
abstract: An efficient method for Markownikoff's hydroamination-hydroarylation of alkynols using PtBr(2) as catalyst has been developed. The platinum-catalyzed reactions of alkynols with amino group containing aromatics were achieved in methanol over a reaction time of 6-24 h and temperature ranging from rt to 80 degrees C. This method works well for a variety of alkynols and aromatic amino compounds to give substituted pyrrolo[1,2-a]quinoxalines and indolo[3,2-c]quinolines in good to excellent yields.
authors.affiliation: Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad 500 607, India. nitin@iict.res.in
authors.forename: Nitin T
authors.initials: NT
authors.lastname: Patil
authors.forename: Rahul D
authors.initials: RD
authors.lastname: Kavthe
authors.forename: Vivek S
authors.initials: VS
authors.lastname: Raut
authors.forename: Vaddu V N
authors.initials: VV
authors.lastname: Reddy