title: [Immune reaction to anesthesia and surgical injury in neonatal infants].
abstract: The impact of surgical injury and anesthesia on cellular and humoral immunity parameters was studied in neonatal infants with surgical pathology. These were found to have immunosuppressive activity, which appeared as evolving absolute lymphopenia and a reduction in the serum concentration of IgG. The magnitude of these changes depends on the functional state of the immune system in the preoperative period and is higher in infants with signs of an infectious-inflammatory process in the preoperative period, which increases the risk of septic complications. Preoperative immune replacement therapy with intravenous immunoglobulins (Pentaglobin) in neonates with severe developmental defects stops a fall in the level of cytotoxic lymphocytes in the early postoperative period.
authors.forename: A D
authors.initials: AD
authors.lastname: Sepbaeva
authors.forename: V A
authors.initials: VA
authors.lastname: Mikhel'son
authors.forename: M V
authors.initials: MV
authors.lastname: Degtiareva
authors.forename: N K
authors.initials: NK
authors.lastname: Marveeva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Zhirkova
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects; D000013:Congenital Abnormalities / Q000601:surgery; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D056724:Immunity, Humoral / Q000276:immunology; D007070:Immunoglobulin A / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007075:Immunoglobulin M / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007231:Infant, Newborn; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008231:Lymphopenia / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D011183:Postoperative Complications / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D011292:Premedication / Q000379:methods*
chemical_list: D007070:Immunoglobulin A; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; C060166:pentaglobulin