title: Genomic expression profiles in liver of mice exposed to purified terephthalic acid manufacturing wastewater.
abstract: DNA micorarray was used to analyze hepatic transcriptional profile of male mice (Mus musculus) after 35-d intragastric perfusion treatment with purified terephthalic acid (PTA) manufacturing wastewater. Haematological analysis demonstrated that the levels of glutamyl transferase and lactate dehydrogenase in serum were significantly decreased, and DNA microarray showed that a total of 306 genes were differentially expressed in PTA wastewater-treated mice. According to Kyoto encyclopedia of genes and genomes pathway database, the differentially expressed genes were mainly grouped to metabolic pathways (58 genes) and biological processes (101 genes). PTA wastewater had significant impacts upon metabolisms of lipid, carbohydrate, amino acid, vitamin and nucleotide. Several signal transduction pathways are most susceptible to PTA wastewater, including mitogen-activated protein kinases, Janus kinase/signal transducers and activators of transcription and calcium signaling pathways. Potential public health problems may arise from the discharge of PTA wastewater into the environment.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China.
authors.forename: Zongyao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Liping
authors.initials: L
authors.lastname: Ma
authors.forename: Xu-Xiang
authors.initials: XX
authors.lastname: Zhang
authors.forename: Weixin
authors.initials: W
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Liuyan
authors.initials: L
authors.lastname: Yang
authors.forename: Shupei
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling / Q000379:methods*; D016678:Genome / Q000235:genetics*; D007220:Industrial Waste / Q000009:adverse effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D010795:Phthalic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis; D015398:Signal Transduction / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007220:Industrial Waste; D010795:Phthalic Acids; D012333:RNA, Messenger; D014874:Water Pollutants, Chemical; C011363:terephthalic acid; D007770:L-Lactate Dehydrogenase