Exercise-induced growth hormone response in euglycaemia and hyperglycaemia in patients with Type 1 diabetes mellitus.
OBJECTIVE
To compare exercise-induced growth hormone (GH) response in patients with Type 1 diabetes during stable euglycaemic and hyperglycaemic conditions.


METHODS
We conducted a randomized, controlled, single-blinded cross-over trial in seven male patients with well-controlled Type 1 diabetes. The patients cycled twice for 120 min at a level of 55-60% maximal oxygen uptake. Euglycaemia was at 5.0 mmol/l, hyperglycaemia at 11.0 mmol/l.


RESULTS
Area under the curve of GH (AUC(GH)) during exercise was significantly higher during euglycaemia [1430 ng ml(-1) min, 95% confidence interval (CI) 703-2910] compared with hyperglycaemia (1061 ng ml(-1) min, 95% CI 538-2091, P = 0.02).


CONCLUSIONS
In patients with Type 1 diabetes, GH concentrations during moderate aerobic exercise during stable hyperglycaemic conditions are significantly lower compared with euglycaemia. These findings are compatible with preserved glucose-mediated GH regulation during exercise in individuals with well-controlled Type 1 diabetes.
Jenni
S
S
Division of Endocrinology, Diabetes and Clinical Nutrition, University of Bern, University Hospital, Bern, Switzerland.
Christ
E R
ER
Stettler
C
C
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D015309:Glucose Clamp Technique; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male
D001786:Blood Glucose; D013006:Growth Hormone