Chemical constituents from Delphinium chrysotrichum and their biological activity.
A new diterpene alkaloid named delphatisine C (1) has been isolated from aerial parts of Delphinium chrysotrichum along with three known norditerpenoid alkaloids delpheline (2), delbrunine (3), and delectinine (4). Their structures were characterized on the basis of their spectral data. All of them were determined by SRB assay for their cytotoxicity, and compound (1) showed significant cytotoxic activities (IC(50)=2.36 μmol/L) against the A549 cell line.
He
Yang-Qing
YQ
Department of Applied Chemistry, Xi'an University of Technology, Xi'an 710054, PR China. hyq7978863@163.com
Ma
Zhan-Ying
ZY
Wei
Xiao-Mei
XM
Du
Bao-Zhong
BZ
Jing
Zhan-Xin
ZX
Yao
Bing-Hua
BH
Gao
Li-Ming
LM
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D031882:Delphinium / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D015394:Molecular Structure; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C557535:delphatisine C