[Study of the relationship between the micro-lymphatic vessel density and invasion and metastasis in gastric carcinoma].
OBJECTIVE
To investigate the relationship between the micro-lymphatic vessel density (LMVD) and invasion and metastasis in gastric carcinoma.


METHODS
The expression of LYVE-1 in 52 cases of gastric carcinoma was detected by immunohistochemical SP method, by which the LMVD was calculated.


RESULTS
The lymphangiogenesis was shown in peritumoral tissue in gastric carcinoma. LMVD of gastric carcinoma was higher than that of normal gastric tissue (P<0.05). LMVD with lymphatic metastasis was higher than that without lymphatic metastasis (P<0.05); LMVD with big tumor (diameter >5 cm) was higher than that with small tumor (diameter <5 cm) (P<0.05); LMVD with serosal invasion was higher than that without serosal invasion (P<0.05).


CONCLUSIONS
LMVD is closely related to lymph node metastasis, tumor size and invasive depth, which is helpful to determine the prognosis of gastric cancer and treatment program evaluation.
Huang
Zhen-bu
ZB
Wenzhou Medical College, Wenzhou Medicine Hospital, Wenzhou, China. yichong88@hotmail.com
Nie
Han-qiu
HQ
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000378:metabolism*; D008297:Male; D055806:Microvessels / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000276:immunology / Q000473:pathology*