Dibenzocyclooctadiene lignans from the fruits of Schisandra wilsoniana and their anti-HIV-1 activities.
Three new dibenzocyclooctadiene lignans, wilsonilignans A-C (1-3), together with nine known ones, were isolated from the fruits of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1-3 were also evaluated for their anti-HIV-1 activities and showed bioactivity with EC(50) values of 3.26, 6.18, and 2.87 microg/ml, respectively.
Yang
Guang-Yu
GY
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Li
Yin-Ke
YK
Wang
Rui-Rui
RR
Xiao
Wei-Lie
WL
Yang
Liu-Meng
LM
Pu
Jian-Xin
JX
Zheng
Yong-Tang
YT
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D015497:HIV-1 / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032141:Schisandra / Q000737:chemistry*
D019380:Anti-HIV Agents; D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; C550648:wilsonilignan A; C550649:wilsonilignan B; C550650:wilsonilignan C