title: Infectious syphilis unmasking drug resistance in an individual with long-term virological suppression on antiretroviral therapy.
abstract: This case report describes the case of an HIV-positive individual who had long-term virological suppression on antiretroviral therapy, who manifested HIV drug resistance during a syphilis-induced HIV viral load increase. This highlights how the acquisition of a sexually transmitted infection can have important ramifications for HIV suppression and potential HIV transmission to sexual partners.
authors.affiliation: Department of Genitourinary Medicine and HIV, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. phillread@doctors.org.uk
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Read
authors.forename: Julie
authors.initials: J
authors.lastname: Fox
mesh_terms: D000328:Adult; D024882:Drug Resistance, Viral / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D018451:Homosexuality, Male; D006801:Humans; D033162:Incidental Findings; D008297:Male; D009154:Mutation; D010612:Pharyngitis / Q000821:virology; D013587:Syphilis / Q000175:diagnosis*; D014456:Ulcer / Q000821:virology; D019562:Viral Load