Ketogenic diet for treatment of epilepsy.
OBJECTIVE
Families of children with epilepsy now ask about the ketogenic diet at clinic visits. Is it effective and safe to use for treatment of epilepsy?


CONCLUSIONS
The ketogenic diet can be considered an option for children with intractable epilepsy who use multiple antiepileptic drugs. It is a treatment of choice for seizures associated with glucose transporter protein deficiency syndrome (ie, De Vivo disease) and pyruvate dehydrogenase complex deficiency. The diet's strictness, unpalatability, and side effects limit its use, adversely affecting patients' compliance and clinical efficacy.
Rogovik
Alexander L
AL
BC Children's Hospital, Department of Pediatrics, Vancouver, BC V6H 3V4, Canada.
Goldman
Ran D
RD
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D055423:Diet, Ketogenic / Q000009:adverse effects / Q000379:methods*; D004827:Epilepsy / Q000178:diet therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D012640:Seizures / Q000517:prevention & control