title: A patient with lichen sclerosus, Langerhans cell histiocytosis, and invasive squamous cell carcinoma of the vulva.
abstract: We report a patient with vulvar lichen sclerosus, Langerhans cell histiocytosis (LCH), and later vulvar cancer. In LCH, high amounts of non functional Langerhans cells are present in the affected tissue, making it possible that LCH may have contributed to vulvar cancer development in this patient.
authors.affiliation: Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, The Netherlands.
authors.forename: Michiel
authors.initials: M
authors.lastname: Simons
authors.forename: Hedwig P
authors.initials: HP
authors.lastname: Van De Nieuwenhof
authors.forename: Irene A M
authors.initials: IA
authors.lastname: Van Der Avoort
authors.forename: Johan
authors.initials: J
authors.lastname: Bulten
authors.forename: Joanne A
authors.initials: JA
authors.lastname: De Hullu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D007724:Vulvar Lichen Sclerosus / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy
chemical_list: D000305:Adrenal Cortex Hormones