Dimethylbenz[alpha]anthracene induces oxidative stress and reduces the binding capacity of the mitochondrial 18-kDa translocator protein in rat aorta.
In this study, rats surviving 18 weeks after 7,12-dimethylbenz[a]anthracene (DMBA) exposure showed robust pathological changes in the aorta. This correlated well with decreases in 18-kDa translocator protein (TSPO) binding capacity in this tissue. As expected, markers for oxidative stress, including thiobarbituric-acid-reactive substances, and advanced oxidation protein products, showed that the applied DMBA exposure increased oxidative stress in the aorta. Our study suggests that TSPO may be involved in toxic DMBA effects in the aorta, including inflammatory responses and reactive oxygen species generation.
Dimitrova-Shumkovska
Jasmina
J
Department of Biochemistry and Physiology, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia. jasminad@iunona.pmf.ukim.edu.mk
Veenman
Leo
L
Ristoski
Trpe
T
Leschiner
Svetlana
S
Gavish
Moshe
M
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002352:Carrier Proteins / Q000378:metabolism*; D008024:Ligands; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
D002352:Carrier Proteins; D008024:Ligands; D024101:Mitochondrial Proteins; D011963:Receptors, GABA-A; D017392:Thiobarbituric Acid Reactive Substances; C069997:Tspo protein, rat; D015127:9,10-Dimethyl-1,2-benzanthracene