[CD80 and CD86 coreceptors expression on lymphocytes B in hypertrophied adenoids in children with otitis media with effusion].
OBJECTIVE
The aim of this study was evaluation of the percentage and mean fluorescence intensity of lymphocytes B with expression CD80 and CD86 in hypertrophied adenoids in children with otitis media with effusion.


METHODS
Expression coreceptors CD80 and CD86 on lymphocytes B in adenoid tissue were estimated by flow cytometry method. 15 children with otitis media with effusion and 15 children with hypertrophied adenoid were tested.


RESULTS
This study showed significantly higher percentage of lymphocytes CD19+ CD80+ in children with otitis media with effusion (OME 1.42% +/- 0.91) than in comparative group with hypertrophied adenoids (AH 0.63% +/- 0.21). The receptor CD86 didn't show differences in expression on lymphocytes B between both examinated groups.


CONCLUSIONS
Low expression of CD80 and CD86 indicates that local immunity response in hypertrophied adenoids in children with otitis media with effusion is weakened. It can contribute to the otitis media with effusion.
Ratomski
Karol
K
Zaklad Laboratoryjnej Diagnostyki, Pediatrycznej Uniwersytetu Medycznego w Białymstoku. karol.cam@interia.pl
Zelazowska-Rutkowska
Beata
B
Wysocka
Jolanta
J
Skotnicka
Bozena
B
Kasprzycka
Edwina
E
Ilona
Bauer
B
D000234:Adenoids / Q000276:immunology* / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D001402:B-Lymphocytes / Q000378:metabolism*; D018122:B7-1 Antigen / Q000378:metabolism*; D051940:B7-2 Antigen / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000276:immunology; D008297:Male; D010034:Otitis Media with Effusion / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D011044:Poland; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D018122:B7-1 Antigen; D051940:B7-2 Antigen