title: Syntheses of trans-SCH-A and cis-SCH-A via a stereodivergent cyclopropanation protocol.
abstract: A highly diastereoselective cyclopropanation protocol has been employed in the syntheses of trans-SCH-A and cis-SCH-A. This strategy encompasses a stereodivergent procedure for the preparation of syn- and anti-cyclopropane diastereoisomers in high dr from a common allylic carbamate precursor.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Kristína
authors.initials: K
authors.lastname: Csatayová
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Davies
authors.forename: James A
authors.initials: JA
authors.lastname: Lee
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Ling
authors.forename: Paul M
authors.initials: PM
authors.lastname: Roberts
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Russell
authors.forename: James E
authors.initials: JE
authors.lastname: Thomson
mesh_terms: D003521:Cyclopropanes / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D003521:Cyclopropanes; D009570:Nitriles; D010879:Piperazines; D017481:Receptors, Somatostatin; C511125:SCH-A compound; D014508:Urea; C030797:cyclopropane