Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'.
OBJECTIVE
This review summarizes research literature regarding mucosal immunity to HIV and simian immunodeficiency virus (SIV), with an emphasis on work published within the past 18 months.


RESULTS
Notable recent studies have focused on the pivotal events occurring within mucosal tissues during acute HIV/SIV infection that serve to establish a balance between detrimental immune activation and beneficial adaptive responses. In cervicovaginal mucosa, an early inflammatory response leads to recruitment of susceptible target cells. At this acute stage, the in-vivo ratio between CD8 effector cells and infected CD4 T-cells may be critical for limiting viral dissemination. Acute infection is also accompanied by loss of germinal center architecture and T/B cell apoptosis in Peyer's patches of the gastrointestinal tract. During chronic infection, mucosal CD8 T-cells may play a role in immune control, as suggested by studies of elite controllers.


CONCLUSIONS
Mucosal tissues serve as the major portal of entry for HIV, and house a majority of the body's lymphocytes, including CD4 T-cells that are targets for infection. Recent studies have focused renewed attention on events occurring immediately after transmission, and underscore the concept that the balance between inflammation and protective immunity is established by host responses in mucosal tissues.
Shacklett
Barbara L
BL
Department of Medical Microbiology and Immunology, School of Medicine, University of California-Davis, 1 Shields Avenue, Davis, CA 95616, USA. blshacklett@ucdavis.edu
D000818:Animals; D005260:Female; D005836:Genitalia, Female / Q000276:immunology / Q000473:pathology; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology