title: Familial prevalence of celiac disease.
abstract: OBJECTIVE
  Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening.
  
  
  METHODS
  A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.
  
  
  RESULTS
  A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.
  
  
  CONCLUSIONS
  Family members of CD cases represent potential cases of CD.
authors.affiliation: Division of Pediatric Gastroenterology Hepatology and Nutrition, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. brthapa1@yahoo.co.in
authors.forename: Babu Ram
authors.initials: BR
authors.lastname: Thapa
authors.forename: Pawan
authors.initials: P
authors.lastname: Rawal
authors.forename: Bharat
authors.initials: B
authors.lastname: Sapra
authors.forename: Kim
authors.initials: K
authors.lastname: Vaiphei
authors.forename: Chander Kanwal
authors.initials: CK
authors.lastname: Nain
authors.forename: Kartar
authors.initials: K
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004384:Duodenoscopy; D004386:Duodenum / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005190:Family; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D020022:Genetic Predisposition to Disease; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007194:India / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases