title: In vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum.
abstract: This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.
authors.affiliation: Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil. brilhante@ufc.br
authors.forename: Raimunda Sâmia Nogueira
authors.initials: RS
authors.lastname: Brilhante
authors.forename: Maria Auxiliadora Bezerra
authors.initials: MA
authors.lastname: Fechine
authors.forename: Rossana de Aguiar
authors.initials: Rde A
authors.lastname: Cordeiro
authors.forename: Marcos Fábio Gadelha
authors.initials: MF
authors.lastname: Rocha
authors.forename: Joyce Fonteles
authors.initials: JF
authors.lastname: Ribeiro
authors.forename: André Jalles
authors.initials: AJ
authors.lastname: Monteiro
authors.forename: Rita Amanda Chaves
authors.initials: RA
authors.lastname: de Lima
authors.forename: Jacó Ricarte Lima
authors.initials: JR
authors.lastname: Mesquita
authors.forename: Zoilo Pires
authors.initials: ZP
authors.lastname: de Camargo
authors.forename: José Júlio Costa
authors.initials: JJ
authors.lastname: Sidrim
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D006658:Histoplasma / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D014295:Trimethoprim; D013420:Sulfamethoxazole