Pilomyxoid astrocytoma.
Pilomyxoid astrocytoma (PMA) is a recently described brain tumor. PMA shares similar features with pilocytic astrocytoma (PA), the most common central nervous system (CNS) tumor in the pediatric population, yet displays subtle histologic differences. We describe a case of PMA in a six-year-old male involving sellar and suprasellar region presenting with failure to thrive and delayed developmental milestones. The histological findings revealed a tumor composed of a monotonous population of loosely arranged cells with delicate piloid like processes, within a prominent myxoid background. The tumor lacked biphasic appearance, Rosenthal fibers, eosinophilic granular bodies and calcification that are commonly observed in classical PA. Previous studies have shown PMA to behave more aggressively than PA, with shorter progression-free survival as well as a higher rate of recurrence and CNS dissemination. Thus, recognition of PMA and its distinction from classical PA is very important.
Azad
Sheenam
S
Department of Pathology, Shri Mahant Indresh Hospital, Shri Guru Ram Rai Institute of Health & Medical Sciences, Patel Nagar, Dehradun, India.
Kudesia
Sandip
S
Chawla
Nitin
N
Azad
Rajiv
R
Singhal
Mini
M
Rai
Suraj Ml
SM
Arora
Pankaj
P
D001254:Astrocytoma / Q000175:diagnosis* / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008853:Microscopy; D012658:Sella Turcica / Q000473:pathology; D014057:Tomography, X-Ray Computed