Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors.
Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
Zanoni
Ivan
I
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.
Granucci
Francesca
F
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology / Q000378:metabolism; D016923:Cell Death; D002465:Cell Movement; D002470:Cell Survival / Q000502:physiology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D051193:Toll-Like Receptors / Q000378:metabolism*
D000941:Antigens; D051193:Toll-Like Receptors