Programmed to direct alloimmunity.
After an allograft placement, the body faces an intricate task of mounting a balanced immune response to foreign antigens. The ideal response entails maintaining enough immunity to prevent infections and cancer yet not endangering the ability to achieve and maintain organ tolerance. Programmed death-1 and its ligands expressed on non-professional antigen-presenting cells such as the renal tubular epithelium function to downregulate allogenic T-cell responses and thus play an important role in achieving this balance.
Swaminathan
Sundararaman
S
Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Affairs Medical Center, Little Rock, Arkansas 72211, USA. sswaminathan@uams.edu
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D006648:Histocompatibility / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007109:Immunity / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology