title: [The pathological characteristics and clinical significances of maturational change of port-wine stain].
abstract: OBJECTIVE
  In this study histologic observations were presented to elucidate the possible mechanism of maturational change of port-wine stain(PWS).
  
  
  METHODS
  Normal PWS(3 cases) , thicken PWS (11 cases) and nodular PWS (9 cases) were included to present histologic observations.
  
  
  RESULTS
  Normal PWS, only shows mild dilated, thin-walled vessels within superficial dermis. Thicken PWS, shows further dilated vessels and sebaceous gland throughout dermis and superficial subcutaneous fat. Nodular PWS can be divided into three groups. I Similar to thicken PWS, shows further dilated vessels and sebaceous gland throughout dermis and superficial subcutaneous fat. II Shows Large number of dilated vessels, honeycombing and less vascular mesenchymal. III Tenacious texture shows mild dilated vessels, diffused collagen, mesenchymal rarefaction, lymphocyte infiltration and lymphedema change.
  
  
  CONCLUSIONS
  Histologic examination revealed not only the expected vascular abnormalities, but also a number of widely distributed hamartomatous changes in thicken and nodular PWS. The complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of PWS.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiaotong University, Shanghai 200011, China. docwang001@gmail.com
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiao-xi
authors.initials: XX
authors.lastname: Lin
authors.forename: Gang
authors.initials: G
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Hu
authors.forename: Yun-bo
authors.initials: YB
authors.lastname: Jin
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Chuan
authors.initials: C
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019339:Port-Wine Stain / Q000473:pathology*; D055815:Young Adult