title: Chromosomal anomaly spectrum in early pregnancy loss in relation to presence or absence of an embryonic pole.
abstract: OBJECTIVE
  To compare the cytogenetic findings in a series of missed miscarriages evaluated by chorionic villus sampling, in relation to embryonic pole presence (embryonic or anembryonic).
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Tertiary referral hospital.
  
  
  METHODS
  Women presenting with a missed miscarriage.
  
  
  METHODS
  Transcervical chorionic villus sampling and cytogenetic studies in the chorionic villi with use of the semidirect method.
  
  
  METHODS
  Embryonic pole presence or absence assessed by transvaginal ultrasound examination. Type of chromosomal anomalies found in both subgroups.
  
  
  RESULTS
  Although the chromosomal abnormality rate was similar for miscarriages with absent or present embryo (61% vs. 68% respectively), frequencies for viable autosomal trisomies (2.3% vs. 19%) and monosomy X (0% vs. 9.2%) were significantly lower when no embryonic pole was seen.
  
  
  CONCLUSIONS
  Viable autosomal trisomies and monosomies X appear not to be a common cause of miscarriage with an early fetal demise (anembryonic miscarriage).
authors.affiliation: Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, University of Barcelona Medical School, Barcelona, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Muñoz
authors.forename: Marta
authors.initials: M
authors.lastname: Arigita
authors.forename: Mar
authors.initials: M
authors.lastname: Bennasar
authors.forename: Anna
authors.initials: A
authors.lastname: Soler
authors.forename: Aurora
authors.initials: A
authors.lastname: Sanchez
authors.forename: Antoni
authors.initials: A
authors.lastname: Borrell
mesh_terms: D000030:Abortion, Missed / Q000453:epidemiology / Q000235:genetics; D000328:Adult; D015193:Chorionic Villi Sampling / Q000706:statistics & numerical data; D002869:Chromosome Aberrations; D003430:Cross-Sectional Studies; D020732:Cytogenetic Analysis; D020964:Embryo Loss / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D004622:Embryo, Mammalian / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008875:Middle Aged; D020897:Organizers, Embryonic / Q000000981:diagnostic imaging / Q000473:pathology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal / Q000706:statistics & numerical data; D055815:Young Adult