Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men.
Omentin-1 is a newly discovered protein expressed and secreted from visceral adipose tissue that increases insulin sensitivity.We examined the effects of 12 weeks of aerobic training on serum omentin-1 concentrations together with cardiovascular risk factors in overweight and obese men. Eighteen overweight and obese participants (age 43.1 ± 4.7 years, BMI ≥ 25 kg . m ⁻² ) were assigned to exercise training (n = 9) and control (n = 9) groups. A matched control group of normal weight participants (n = 8; age 42.2 ± 3.8 years, BMI < 25 kg . m ⁻² ) were also recruited for baseline comparison. The obese exercise group participated in 12 weeks of progressive aerobic training 5 days a week. Measures of serum omentin-1, insulin resistance, lipid profiles, blood pressure, and body composition were obtained before and after the 12 weeks. At baseline, normal weight participants had significantly higher serum omentin-1 concentrations than overweight and obese participants, and there were inverse correlations between omentin-1 and each of waist circumference, fasting glucose, insulin resistance, total cholesterol,triglyceride, and systolic blood pressure (P < 0 .05). After the aerobic training, waist circumference, percent body fat, fasting glucose, insulin resistance, triglyceride, total cholesterol, low-density lipoprotein cholesterol, and systolic blood pressure were all significantly decreased (P < 0.05). In contrast, serum omentin-1 concentration was significantly increased after the aerobic programme (P < 0.05), and correlated with changes in insulin resistance (r = − 0.67, P= 0.04), glucose (r = − 0.65, P = 0.05), waist circumference (r = −70, P = 0.03), and aerobic fitness r = −.68, P = 0.04). Aerobic training resulted in an improvement in cardiometabolic risk factors in obese participants, and this improvement was accompanied by increased omentin-1 concentrations.
Saremi
A
A
Department of Sport Sciences, University of Arak, Arak, Iran. a-saremi@araku.ac.ir
Asghari
M
M
Ghorbani
A
A
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D016207:Cytokines / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D050177:Overweight / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors
D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D008055:Lipids