title: [Elderly patient with recurrent rectal cancer successfully responded to modified FOLFOX6 chemotherapy with bevacizumab--a case report].
abstract: An 80-year-old female visited our hospital with the chief complaint of lower abdominal pain and diarrhea. She was diagnosed to have rectal cancer. Hartmann operation was performed and curative resection was successfully achieved. Postoperative stage was III according to the classification of the Japanese Society for Cancer of the Colon and Rectum(The 7th Edition). She was treated with oral tegafur(UFT 300mg/body/day)as adjuvant chemotherapy for 6 months. Paraaortic lymph node metastasis and local recurrence were diagnosed by abdominal CT 1 year after the surgery. Her performance status score was 0. She was treated with modified FOLFOX6 chemotherapy combined with bevacizumab. Abdominal CT revealed a partial response after 5 courses. She experienced grade 2 leukocyopenia, grade 3 neutropenia, grade 2 proteinuria and grade 2 hypertension.
authors.affiliation: Department of Surgery, Tosei General Hospital.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kawase
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kato
authors.forename: Osamu
authors.initials: O
authors.lastname: Okochi
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Matsushita
authors.forename: Masashi
authors.initials: M
authors.lastname: Hattori
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takami
authors.forename: Shigeomi
authors.initials: S
authors.lastname: Takeda
authors.forename: Akira
authors.initials: A
authors.lastname: Mizuno
authors.forename: Eri
authors.initials: E
authors.lastname: Adachi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sato
authors.forename: Masanori
authors.initials: M
authors.lastname: Kuroiwa
mesh_terms: D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000068258:Bevacizumab; D002955:Leucovorin; D005472:Fluorouracil