Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics.
BACKGROUND
In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts (WI-38 human diploid fibroblasts) is considered as logistic only.


RESULTS
We demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy.


CONCLUSIONS
These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy.
Feizabadi
Mitra S
MS
Physics Department, Seton Hall University, South Orange, NJ 07079, USA. shojanmi@shu.edu
Witten
Tarynn M
TM
D000368:Aged; D000375:Aging / Q000473:pathology*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002455:Cell Division; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents