title: Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits.
abstract: We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2.
authors.affiliation: Department of Basic Science and Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea.
authors.forename: Sangtae
authors.initials: S
authors.lastname: Oh
authors.forename: Byong-Gon
authors.initials: BG
authors.lastname: Park
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000502:physiology; D008386:Marine Biology; D011817:Rabbits; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D000096:Acetone