Expression of 2 transcripts of NGX6 gene in colorectal cancer and the correlation with carcinoembryonic antigen.
OBJECTIVE
To investigate the expression and function of NGX6-S (short transcript) and NGX6-L (long transcript) in colorectal cancer.


METHODS
In situ hybridization was used to detect the expression of these 2 transcripts in colorectal cancer tissues and paired normal tissues, and analyze the correlation between NGX6 and carcinoembryonic antigen (CEA).


RESULTS
The expression of NGX6-S was higher than that of NGX6-L in the colorectal cancer tissues (P=0.008). The expressions of NGX6-S and NGX6-L were not different among the 4 stages of colorectal cancer (P>0.05). The expression of NGX6-S in the colorectal cancer tissues of Duke A, B, and C stages had no difference with that of the paired normal tissues (P>0.05). Inversely, the expression of NGX6-S in the colorectal cancer tissues of Duke D stage was lower than that in the paired normal tissues (P=0.033). NGX6-L expression was not different between the colorectal cancer tissues and the paired normal tissues in 4 stages(P>0.05).The expression of NGX6-S and NGX6-L had no correlation with the serum concentration of CEA.


CONCLUSIONS
NGX6-S may play an important role in colorectal cancer, and the lowered expression of NGX6-S may contribute to the distant metastasis of colorectal cancer.
Su
Zheng
Z
Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Wang
Xiaoyan
X
Shen
Shourong
S
Wang
Li
L
Li
Yu
Y
Li
Nan
N
Li
Zeng
Z
D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
D002272:Carcinoembryonic Antigen; D008565:Membrane Proteins; C477325:TMEM8B protein, human; D025521:Tumor Suppressor Proteins