title: [A case of gastric cancer with para-aortic lymph node metastasis successfully treated with S-1/paclitaxel/lentinan combination therapy].
abstract: A 70-year-old male presented with gastric cancer with para-aortic lymph node metastasis. The patient was given combination chemotherapy of S-1, paclitaxel and Lentinan. Lymph node metastases were reduced in number at the end of one course. At the end of the eighth course, the lesions were markedly reduced but no further reduction was observed thereafter. The primary lesion was also markedly reduced, and a distal gastrectomy(D1+a)was performed because of remaining tumor tissue detected by biopsy. Pathological findings revealed pT1(SM), pN0, P0, CY0, H0, M0, and Stage IA, respectively. After surgery, this treatment was continued for 4 years and one month from the initiation of this therapy(2 years and six months from gastrectomy). During the period of treatment, there was no relapse nor serious adverse events.
authors.affiliation: Department of Surgery, Teramoto Memorial Hospital.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yanagawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Satoru
authors.initials: S
authors.lastname: Noda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001011:Aorta / Q000473:pathology*; D001706:Biopsy; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D007912:Lentinan / Q000008:administration & dosage / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D007912:Lentinan; D010094:Oxonic Acid; D017239:Paclitaxel