microRNAs: a role in drug resistance in parasitic nematodes?
Drug resistance in parasitic nematodes is an increasing problem worldwide, with resistance reported to all three commonly used classes of anthelmintics. Most studies to date have sought to correlate the resistant phenotype with genotypic changes in putative target molecules. Although this approach has identified mutations in several relevant genes, resistance might result from a complex interaction of different factors. Here we propose an alternative mechanism underlying the development of drug resistance based on functional differences in microRNA activity in resistant parasites. microRNAs play an important role in resistance to chemotherapeutic agents in many tumour cells and here we discuss whether they might also be involved in anthelmintic resistance in parasitic nematodes.
Devaney
Eileen
E
Parasitology Group, Division of Veterinary Infection and Immunity, Institute for Comparative Medicine, School of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK. e.devaney@vet.gla.ac.uk
Winter
Alan D
AD
Britton
Collette
C
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004351:Drug Resistance / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009348:Nematoda / Q000187:drug effects* / Q000235:genetics
D000969:Antinematodal Agents; D035683:MicroRNAs