Targeted Nanodelivery of Drugs and Diagnostics.
Nanomaterials for targeted delivery are uniquely capable of localizing delivery of therapeutics and diagnostics to diseased tissues. The ability to achieve high, local concentrations of drugs or image contrast agents at a target site provides the opportunity for improved system performance and patient outcomes along with reduced systemic dosing. In this review, the design of targeted nanodelivery systems is discussed with an emphasis on in vivo performance, the physicochemical properties that affect localization at the target site, and the incorporation of therapeutic drugs into these systems.
Phillips
Margaret A
MA
Department of Biomedical Engineering, Department of Chemical Engineering, Division of Pharmacy, The University of Texas at Austin, Austin, TX 78712.
Gran
Martin L
ML
Peppas
Nicholas A
NA