[Normal tissue tolerance to external beam radiation therapy: adult bone].
Radiation tolerance for bone tissue has been mostly evaluated with regard to bone fracture. Main circumstances are mandibula osteoradionecrosis, hip and costal fracture, and patent or radiologic fractures in the treated volume. After radiation therapy of bone metastasis, the analysis of related radiation fracture is difficult to individualize from a pathologic fracture. Frequency of clinical fracture is less than 5% in the large series or cohorts and is probably underevaluated for the asymptomatic lesions. Women older than 50 years and with osteoporosis are probably the main population at risk. Dose-effect relations are difficult to qualify in older series. Recent models evaluating radiations toxicity on diaphysa suggest an important risk after 60 Gy, for high dose-fraction and for a large volume.
Sargos
P
P
Département de Radiothérapie, Centre Régional de Lutte Contre le Cancer, Institut Bergonié, 229 cours de l'Argonne, 33076 Bordeaux cedex, France.
Mamou
N
N
Dejean
C
C
Figueiredo
B Henriques de
BH
Huchet
A
A
Italiano
A
A
Kantor
G
G
D000328:Adult; D001842:Bone and Bones / Q000528:radiation effects*; D018450:Disease Progression; D005260:Female; D050723:Fractures, Bone / Q000150:complications / Q000000981:diagnostic imaging; D006620:Hip Fractures / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D010006:Osteoblasts / Q000528:radiation effects; D010024:Osteoporosis / Q000150:complications; D010025:Osteoradionecrosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries / Q000473:pathology; D011836:Radiation Tolerance; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D012307:Risk Factors; D012509:Sarcoma / Q000532:radiotherapy