Biotransformation of 3-oxo-oleanolic acid by Absidia glauca.
3-Oxo-oleanolic acid (1) was biotransformed in growing cultures of the fungus Absidia glauca, resulting in three novel hydroxylated metabolites, identified as 1β-hydroxy-3-oxo-olean-11-en-28,13-lactone (2), 1β,11α-dihydroxy-3-oxo-olean-12-en-28-oic acid (3), and 1β,11α,21β-trihydroxy-3-oxo-olean-12-en-28-oic acid (4).
Guo
Na
N
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Beijing, PR China.
Zhao
Ying
Y
Fang
Wei-Shuo
WS
D020095:Absidia / Q000378:metabolism*; D001711:Biotransformation; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*
C557823:1beta,11alpha,21beta-trihydroxy-3-oxo-olean-12-en-28-oic acid; C557822:1beta,11alpha-dihydroxy-3-oxo-olean-12-en-28-oic acid; C557824:1beta-hydroxy-3-oxo-olean-11-en-28,13-lactone; D009828:Oleanolic Acid