title: A back-to-back comparison of white light video endoscopy with autofluorescence endoscopy for adenoma detection in high-risk subjects.
abstract: OBJECTIVE
  To compare the sensitivity of autofluorescence endoscopy (AFE) and white light video endoscopy (WLE) for the detection of colorectal adenomas in high-risk patients belonging to Lynch syndrome (LS) or familial colorectal cancer (CRC) families.
  
  
  METHODS
  This was a prospective single-centre study carried out in a tertiary referral centre. The subjects were 75 asymptomatic patients originating from LS or familial CRC families. Patients were examined with either WLE followed by AFE or AFE followed by WLE. Back-to-back colonoscopy was performed by two blinded endoscopists. All lesions were removed during the second endoscopic procedure. Lesions missed during the second procedure were identified and removed on third pass. The sensitivity calculations for colorectal adenomas were based on histology results. The main outcome measures were the difference in sensitivity between WLE and AFE for the detection of adenomas in patients with LS or familial CRC.
  
  
  RESULTS
  At least one adenoma was detected in 41 (55%) patients. WLE identified adenomas in 28/41 patients and AFE in 37/41 patients, corresponding to a 32% increase. In total 95 adenomas were detected, 65 by WLE and 87 by AFE, resulting in a significantly higher sensitivity of AFE compared with WLE (92% vs 68%; p=0.001). The additionally detected adenomas with AFE were significantly smaller than the adenomas detected by WLE (mean 3.0 mm vs 4.9 mm, p<0.01).
  
  
  CONCLUSIONS
  AFE improves the detection of colorectal adenomas in patients with LS or familial CRC. The results of this study suggest that AFE may be preferable for surveillance of these high-risk patients.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, CE Rotterdam 3015, The Netherlands.
authors.forename: Dewkoemar
authors.initials: D
authors.lastname: Ramsoekh
authors.forename: Jelle
authors.initials: J
authors.lastname: Haringsma
authors.forename: Jan Werner
authors.initials: JW
authors.lastname: Poley
authors.forename: Paul
authors.initials: P
authors.lastname: van Putten
authors.forename: Herman
authors.initials: H
authors.lastname: van Dekken
authors.forename: Ewout W
authors.initials: EW
authors.lastname: Steyerberg
authors.forename: Monique E
authors.initials: ME
authors.lastname: van Leerdam
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D003113:Colonoscopy / Q000379:methods*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005453:Fluorescence; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult