title: Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.
abstract: sp(2)-Iminosugar-type castanospermine analogues bearing an alpha-configured N-, S-, or C-linked pseudoanomeric group have been designed as selective inhibitors of the neutral alpha-glucosidases involved in N-glycoprotein processing; evaluation in breast cancer cell growth indicated a significant antiproliferative potential that was dependent on the nature of the pseudoanomeric group.
authors.affiliation: Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092 Sevilla, Spain.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Sánchez-Fernández
authors.forename: Rocío
authors.initials: R
authors.lastname: Rísquez-Cuadro
authors.forename: Maud
authors.initials: M
authors.lastname: Chasseraud
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ahidouch
authors.forename: Carmen
authors.initials: C
authors.lastname: Ortiz Mellet
authors.forename: Halima
authors.initials: H
authors.lastname: Ouadid-Ahidouch
authors.forename: José M
authors.initials: JM
authors.lastname: García Fernández
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D007212:Indolizines / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry*; D054836:Indolizidines
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D007212:Indolizines; D009005:Monosaccharides; C438934:C-glycoside; C037806:castanospermine; D054836:Indolizidines