Semaphorins and their receptors: novel features of neural guidance molecules.
Semaphorins were originally identified as axon guidance cues involved in the development of the nervous system. In recent years, it is emerging that they also participate in various biological systems, including physiological and pathological processes. In this review, we primarily focus on our cumulative findings for the role of semaphorins and their receptors in the regulation of the immune system, while also summarizing recent progress in the context of cardiovascular system.
Kumanogoh
Atsushi
A
Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Kikutani
Hitoshi
H
D000818:Animals; D002319:Cardiovascular System / Q000254:growth & development / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000276:immunology* / Q000378:metabolism*; D039961:Semaphorins / Q000276:immunology* / Q000378:metabolism*
D011956:Receptors, Cell Surface; D039961:Semaphorins