Biosynthetic approach for the production of new aminoglycoside derivative.
Aminoglycoside antibiotics can be classified into two major groups; streptamine containing and 2-deoxystreptamine containing antibiotics. Here, we report a biosynthetic approach for the fusion of spectinomycin and kanamycin biosynthetic gene clusters to yield the new aminoglycoside derivative, oxykanamycinC, in a non-aminoglycoside producing heterologous host.
Nepal
Keshav Kumar
KK
Department of Pharmaceutical Engineering, SunMoon University, # 100, Kalsan-ri, Tangjeong-myeon, Asan-si, Chungnam 336-708, Republic of Korea.
Yoo
Jin Cheol
JC
Sohng
Jae Kyung
JK
D000617:Aminoglycosides / Q000096:biosynthesis* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D013302:Streptomyces / Q000235:genetics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins