title: Interleukin-10 -1082 gene polymorphism and susceptibility to cervical cancer among Japanese women.
abstract: Polymorphisms in cytokine genes can influence immune responses to human papillomavirus infection, possibly modifying risks of cervical cancer. Using an amplification refractory mutation system-polymerase chain reaction method, we analyzed a single nucleotide polymorphism (A/G) at position -1082 in interleukin-10 promoter region in 440 Japanese women: 173 women with normal cytology, 163 women with cervical intraepithelial neoplasia and 104 women with invasive cervical cancer. The carrier frequency of interleukin-10 -1082 G alleles associated with higher interleukin-10 production increased with disease severity: 9.8% for normal cytology; 19.6% for cervical intraepithelial neoplasia; 29.8% for invasive cervical cancer (P for trend < 0.001). Among cytologically normal women, human papillomavirus infections were more common in those who were positive for an interleukin-10 -1082 G allele (P = 0.04). In conclusion, our data suggest that interleukin-10 -1082 gene polymorphism may serve as a marker of genetic susceptibility to cervical cancer among Japanese women.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan. matsumok@mui.biglobe.ne.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Akinori
authors.initials: A
authors.lastname: Oki
authors.forename: Toyomi
authors.initials: T
authors.lastname: Satoh
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okada
authors.forename: Takeo
authors.initials: T
authors.lastname: Minaguchi
authors.forename: Mamiko
authors.initials: M
authors.lastname: Onuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ochi
authors.forename: Sari
authors.initials: S
authors.lastname: Nakao
authors.forename: Manabu
authors.initials: M
authors.lastname: Sakurai
authors.forename: Azusa
authors.initials: A
authors.lastname: Abe
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000235:genetics* / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology / Q000821:virology
chemical_list: D016753:Interleukin-10; D004247:DNA