A clinical trial of pulpotomy vs. root canal therapy of mature molars.
Root canal therapy (RCT) and tooth extraction are the main treatment options for irreversible pulpitis or its sequelae. Pulpotomy is an alternative treatment; however, more evidence is required. If outcomes of pulpotomy with a calcium-enriched mixture (PCEM) are non-inferior for mature molars with irreversible pulpitis compared with those from one-visit RCT (ORCT), this may be a beneficial treatment option. Four hundred seven individuals met the inclusion criteria and were randomly allocated [PCEM (n = 205), ORCT (n = 202)]. We used NRS questionnaires to record pain intensity. Six-month clinical and radiographic successes were assessed. Individuals in the ORCT arm reported significantly more post-operative pain than those in the PCEM arm (P < 0.001). Clinical success rates in the two arms showed no statistically significant difference; however, the radiographic success rates were significantly greater in the PCEM arm (P < 0.001). This trial suggests PCEM as an alternative for treatment of irreversible pulpitis. If long-term results confirm initial ones, PCEM may revolutionize oral health worldwide.
Asgary
S
S
Iranian Center for Endodontic Research, Dental Research Center, Dental School, Shahid Beheshti University MC, Evin, Postal Code 1983963113, Tehran, Iran. saasgary@yahoo.com
Eghbal
M J
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D017610:Calcium Compounds / Q000627:therapeutic use; D002133:Calcium Sulfate / Q000627:therapeutic use; D002648:Child; D003738:Dental Cements / Q000627:therapeutic use; D004853:Epoxy Resins / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005898:Glass; D006171:Gutta-Percha / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008963:Molar / Q000473:pathology*; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D011145:Polyvinyls / Q000627:therapeutic use; D011671:Pulpitis / Q000628:therapy*; D011672:Pulpotomy / Q000379:methods*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012390:Root Canal Therapy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult; D015034:Zinc Oxide / Q000627:therapeutic use
D000700:Analgesics; C509301:CaO-MgO-SiO2 glass; D017610:Calcium Compounds; D003738:Dental Cements; D004853:Epoxy Resins; D011145:Polyvinyls; D012387:Root Canal Filling Materials; C417772:calcium oxide-diphosphorus pentoxide-silicon dioxide-aluminum oxide glass; C534916:epoxy resin-based root canal sealer; C020872:Cavit; D006171:Gutta-Percha; D015034:Zinc Oxide; D002133:Calcium Sulfate