[Electrophysiological evaluation of the hearing function following cisplatin administration].
Experiments on guinea pigs with the use of electrophysiological methods (short-latency auditory evoked potentials, SLAEPs, and distortion product otoacoustic emission, DPOAE) have demonstrated damage of outer hair cells following application of therapeutic doses of cisplatin. It is concluded that finding of the logarithmic amplitude-time dependence for the first SLAEPs peak permits to diagnose an injury to outer hair cells.
Bogomol'skiĭ
M R
MR
D'iakonova
I N
IN
Rakhmanova
I V
IV
Sapozhnikov
Ia M
IaM
Stakhovskaia
O R
OR
Tikhomirov
A M
AM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000473:pathology; D006309:Hearing / Q000187:drug effects* / Q000502:physiology; D034381:Hearing Loss / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D000970:Antineoplastic Agents; D002945:Cisplatin