Adult stem cells therapy for urine incontinence in women.
The past few years brought high development in obtaining and culturing autologous adult stem cells. In this paper we review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells (MSCs) can be obtained from bone marrow but it is associated with a painful biopsy procedure. Collection of muscle-derived stem cells (MDSCs) is less harmful because the skeletal muscle biopsy is performed with a small caliber needle in local anesthesia. The stem-based therapy could be the next step in the treatment of urinary incontinence. There are still many elements of therapy such as effectiveness or long-term side effects which need to be researched.
Stangel-Wójcikiewicz
Klaudia
K
Department of Gynecology and Oncology, Collegium Medium Jagiellonian University of Kraków. ksw@cm-uj.krakow.pl
Majka
Marcin
M
Basta
Antoni
A
Stec
Małgorzata
M
Pabian
Wojciech
W
Piwowar
Monika
M
Chancellor
Michael B
MB
D000328:Adult; D053687:Adult Stem Cells / Q000637:transplantation*; D005260:Female; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D032446:Myoblasts / Q000637:transplantation; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D023822:Tissue Engineering / Q000379:methods; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000628:therapy*; D014563:Urodynamics; D016387:Women's Health