Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: a case presentation.
Diabetes insipidus (DI) is a rare presenting complication of acute myeloid leukaemia (AML). Typically, the combination of DI and AML is associated with structural abnormalities of the neurohypophysis. We present a case of AML and DI presenting without any abnormalities of the neurohypophysis on radiological scanning and with normal cerebrospinal fluid examination. The AML karyotype at presentation was characterized by the presence of a t(3; 3)(q21; q26) translocation and monosomy 7. After treatment with induction chemotherapy, the patient achieved a complete remission and his DI resolved. At subsequent AML relapse, characterized by a complex karyotype without the t(3; 3)(q21; q26) translocation or monosomy 7, DI did not recur. Our case provides clinical support to the hypothesis that the t(3; 3)(q21; q26) translocation and/or monosomy 7 in AML may directly result in dysregulation of transcription factors resulting in development of DI in AML patients.
Curley
Cameron
C
Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. cameron_curley@health.qld.gov.au
Kennedy
Glen
G
Haughton
Anne
A
Love
Amanda
A
McCarthy
Catherine
C
Boyd
Andrew
A
D000328:Adult; D002893:Chromosomes, Human, Pair 3; D003919:Diabetes Insipidus / Q000150:complications* / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic