Automated heart-type fatty acid-binding protein assay for the early diagnosis of acute myocardial infarction.
We compared an automated quantitative heart-type fatty acid-binding protein (H-FABP) assay with other cardiac-marker assays to examine its usefulness as an early diagnostic marker of acute myocardial infarction (AMI). Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), myoglobin, and H-FABP were obtained from 64 patients with AMI and 53 patients with other conditions (control group). H-FABP was measured by using 2 immunoassays, the H-FABP enzyme-linked immunosorbent assay (ELISA; Biocheck, Foster City, CA) and the H-FABP latex turbidimetric immunoassay (LTIA; HBI, Anyang, Korea). Sensitivities of assays for cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and electrocardiogram (ECG) for the diagnosis of AMI at hospital admission were 39.1%, 59.4%, 64.1%, 68.7%, 70.3%, and 54.7%, respectively. Specificities of cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively. The automated H-FABP (by LTIA) is superior to cTnT, CK-MB, myoglobin, and H-FABP (by ELISA) tests for the diagnosis of AMI in patients admitted within 4 hours from the onset of chest pain.
Kim
Yeongsic
Y
Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea.
Kim
Hyunjung
H
Kim
Soo-Young
SY
Lee
Hae Kyung
HK
Kwon
Hi Jeong
HJ
Kim
Yong Goo
YG
Lee
Jehoon
J
Kim
Hyung Min
HM
So
Byung Hak
BH
D002637:Chest Pain / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D042241:Early Diagnosis; D004562:Electrocardiography; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007840:Latex; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D009211:Myoglobin / Q000097:blood; D009391:Nephelometry and Turbidimetry / Q000379:methods; D011237:Predictive Value of Tests; D012372:ROC Curve; D013997:Time Factors; D020107:Troponin T / Q000097:blood
C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D007840:Latex; D009211:Myoglobin; D020107:Troponin T