title: [Bronchiolitis viruses].
abstract: In Normandy (France), human respiratory syncytial virus (hRSV) was detected in 64.1% of acute bronchiolitis in hospitalized children, rhinovirus in 26.8%, human metapneumovirus (hMPV) in 7.6%, and parainfluenza virus (PIV) in 3.4%. The viruses causing acute bronchiolitis in the community were hRSV (42%), rhinovirus (19.5%), coronavirus (8%), PIV (3.5%), and hMPV (2.5%). In 53.7% of the cases, hRSV infected infants (86.9%), 53.7% being less than 6 months of age. Of the hRSV cases, 48.2% were detected in November and December and 44.5% in January and February. The hRSV epidemic started the 1st or 2nd week of October but it varied from one year to another and from one region to another. hRSV acute bronchiolitis increased from 261 cases in epidemics from 1999-2003 to 341 cases from 2004-2009. Rhinoviruses gave acute bronchiolitis in 38.4% of cases. A rate of 54.6% of viruses was detected in September and October and 38.5% in March and April. A total of 34.2% of infected infants were under 6 months of age, 37.8% between 6 months and 2 years, and 19.5% were between 2 and 5 years old. hMPV epidemics coincided with hRSV epidemics, but they accounted for one-sixth the number of cases. HMPV infected infants (74%) who were older than those infected with hRSV, and the diagnosis was bronchiolitis (59%) and pneumonia (17%). PIV infections (about 100 cases per year) included PIV3 (62.7%), PIV1 (25.3%), and PIV2 (7.3%). PIV1 infections occurred every 2 years in the fall. PIV3 infections were observed every year during the fall and winter, with peaks of infections in the spring in the years without PIV1. There were acute cases of bronchiolitis in 29.8% of PIV3 infections and 18.3% in PIV1 infections.
authors.affiliation: Laboratoire de virologie humaine et moléculaire, CHU de Caen, avenue Georges-Clémenceau, 14033 Caen cedex 9, France. freymuth-f@chu-caen.fr
authors.forename: F
authors.initials: F
authors.lastname: Freymuth
authors.forename: A
authors.initials: A
authors.lastname: Vabret
authors.forename: J
authors.initials: J
authors.lastname: Dina
authors.forename: D
authors.initials: D
authors.lastname: Cuvillon-Nimal
authors.forename: C
authors.initials: C
authors.lastname: Lubin
authors.forename: A
authors.initials: A
authors.lastname: Vaudecrane
authors.forename: B
authors.initials: B
authors.lastname: Guillois
authors.forename: S
authors.initials: S
authors.lastname: Gouarin
authors.forename: J
authors.initials: J
authors.lastname: Petitjean
authors.forename: F
authors.initials: F
authors.lastname: Lafaix-Delaire
authors.forename: J
authors.initials: J
authors.lastname: Brouard
mesh_terms: D001990:Bronchiolitis, Viral / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D002675:Child, Preschool; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics / Q000472:pathogenicity; D012621:Seasons