title: The effects of different loading times on the bone response around dental implants: a histomorphometric study in dogs.
abstract: OBJECTIVE
  The aim of this study was to evaluate, through histomorphometric analysis, the effect that different loading times would have on the bone response around implants.
  
  
  METHODS
  Three Replace Select implants were placed on each side of the mandible in eight dogs (n = 48 implants). One pair of implants was selected for an immediate loading protocol (IL). After 7 days, the second pair of implants received prostheses for an early loading protocol (EL). Fourteen days after implant placement, the third pair of implants received prostheses for advanced early loading (AEL). Following 12 weeks of prosthetics, counted following the positioning of the metallic crowns for the AEL group, the animals were sacrificed and the specimens were prepared for histomorphometric analysis. The differences between loading time in the following parameters were evaluated through analysis of variance: bone-to-implant contact, bone density, and crestal bone loss.
  
  
  RESULTS
  The mean percentage of bone-to-implant contact for IL was 77.9% +/- 1.71%, for EL it was 79.25% +/- 2.11%, and for AEL it was 79.42% +/- 1.49%. The mean percentage of bone density for IL was 69.97% +/- 3.81%, for EL it was 69.23% +/- 5.68%, and for AEL it was 69.19% +/- 2.90%. Mean crestal bone loss was 1.57 +/- 0.22 mm for IL, 1.23 +/- 0.19 mm for EL, and 1.17 +/- 0.32 mm for AEL. There was no statistical difference for any of the parameters evaluated (P > .05).
  
  
  CONCLUSIONS
  Different early loading times did not seem to significantly affect the bone response around dental implants.
authors.affiliation: Department of Dental Materials and Prosthetics, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Sérgio Jorge
authors.initials: SJ
authors.lastname: Jayme
authors.forename: Rafael Ramos
authors.initials: RR
authors.lastname: de Oliveira
authors.forename: Valdir Antonio
authors.initials: VA
authors.lastname: Muglia
authors.forename: Arthur Belém
authors.initials: AB
authors.lastname: Novaes
authors.forename: Ricardo Faria
authors.initials: RF
authors.lastname: Ribeiro
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density; D003442:Crowns; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported / Q000009:adverse effects; D003799:Dental Stress Analysis; D004285:Dogs; D020007:Implants, Experimental; D008297:Male; D008334:Mandible; D016348:Osseointegration; D013997:Time Factors
chemical_list: D015921:Dental Implants