Metabolic profile of first and second generation antipsychotics among Chinese patients.
The metabolic profiles of Chinese patients treated with second-generation antipsychotic (SGA) medication and first-generation antipsychotic (FGA) medication were compared. The sample comprised 99 patients treated with SGA (risperidone, olanzapine and ziprasidone) and 99 with FGA (chlorpromazine, haloperidol and trifluoperazine) from the outpatient clinic of a teaching hospital in Hong Kong. The most frequent psychiatric diagnosis was schizophrenia, followed by affective disorder and other psychiatric diagnoses. Subjects were measured for body weight, body height, fasting lipid and glucose levels. SGA was associated with higher LDL-cholesterol level than FGA. Individual comparison of different antipsychotics showed that patients on olanzapine had the greatest increases in cholesterol and triglycerides among all antipsychotics. The finding suggested SGA, particularly olanzapine, were associated with more metabolic risk factors than first-generation antipsychotics.
Lee
Edwin
E
Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China. elee@cuhk.edu.hk
Chow
Lai-Yin
LY
Leung
Chi-Ming
CM
D000328:Adult; D014150:Antipsychotic Agents / Q000145:classification / Q000378:metabolism / Q000627:therapeutic use; D044466:Asian People; D015992:Body Mass Index; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged
D014150:Antipsychotic Agents; D002784:Cholesterol