The complete inventory of receptors encoded by the rat natural killer cell gene complex.
The natural killer cell gene complex (NKC) encodes receptors belonging to the C-type lectin superfamily expressed primarily by NK cells and other leukocytes. In the rat, the chromosomal region that starts with the Nkrp1a locus and ends with the Ly49i8 locus is predicted to contain 67 group V C-type lectin superfamily genes, making it one of the largest congregation of paralogous genes in vertebrates. Based on physical proximity and phylogenetic relationships between these genes, the rat NKC can be divided into four major parts. We have previously reported the cDNA cloning of the majority of the genes belonging to the centromeric Nkrp1/Clr cluster and the two telomeric groups, the Klre1-Klri2 and the Ly49 clusters. Here, we close the gap between the Nkrp1/Clr and the Klre1-Klri2 clusters by presenting the cDNA cloning and transcription patterns of eight genes spanning from Cd69 to Dectin1, including the novel Clec2m gene. The definition, organization, and evolution of the rat NKC are discussed.
Flornes
Line M
LM
Institute of Basic Medical Sciences, Department of Anatomy, University of Oslo, Oslo, Norway.
Nylenna
Øyvind
Ø
Saether
Per C
PC
Daws
Michael R
MR
Dissen
Erik
E
Fossum
Sigbjørn
S
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D055650:NK Cell Lectin-Like Receptor Subfamily A / Q000235:genetics; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000235:genetics; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000235:genetics; D010802:Phylogeny; D051381:Rats; D055607:Receptors, Natural Killer Cell / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D037181:Lectins, C-Type; D055650:NK Cell Lectin-Like Receptor Subfamily A; D055651:NK Cell Lectin-Like Receptor Subfamily B; D055654:NK Cell Lectin-Like Receptor Subfamily C; D055607:Receptors, Natural Killer Cell; D000099192:CD69 Antigens; C543376:CLEC-1 protein, rat