Bio and nanotechnological strategies for tumor-targeted gene therapy.
Gene therapy is a new medical approach for the treatment of tumors. For safe and efficient gene therapy, therapeutic genes need to be delivered efficiently into the target tumor cells. Development of gene delivery systems to specifically recognize and target tumor cells and to distinguish them from normal cells, especially in the same tissue or organ, is one of the most important issues regarding the present gene delivery methodologies. The enhanced permeability and retention (EPR) effect using the characteristics of angiogenic tumor blood vessels, as well as gene delivery systems recognizing hyperactivated receptors or intracellular signals, is broadly applied to tumor-targeted gene therapy. In addition, bacterial vectors can be a useful means for targeting hypoxic or anoxic regions of a tumor.
Kang
Jeong-Hun
JH
Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan. jrjhkang@ri.ncvc.go.jp
Toita
Riki
R
Katayama
Yoshiki
Y
D001709:Biotechnology / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D009928:Organ Specificity