title: A sensing platform based on electrodissolution of a Ag bipolar electrode.
abstract: Here we report a new type of sensing platform that is based on electrodissolution of a metallic bipolar electrode (BPE). When the target DNA binds to the capture probe at the cathodic pole of the BPE, it triggers the oxidation and dissolution of Ag metal present at the anodic pole. The loss of Ag is easily detectable with the naked eye or a magnifying glass and provides a permanent record of the electrochemical history of the electrode. More importantly, the decrease in the length of the BPE can be directly correlated to the number of electrons passing through the BPE and hence to the sensing reaction at the cathode.
authors.affiliation: Department of Chemistry and Biochemistry and the Center for Electrochemistry, The University of Texas at Austin, 1 University Station, A5300, Austin, Texas 78712-0165, USA.
authors.forename: Kwok-Fan
authors.initials: KF
authors.lastname: Chow
authors.forename: Byoung-Yong
authors.initials: BY
authors.lastname: Chang
authors.forename: Brian A
authors.initials: BA
authors.lastname: Zaccheo
authors.forename: François
authors.initials: F
authors.lastname: Mavré
authors.forename: Richard M
authors.initials: RM
authors.lastname: Crooks