Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence.
Female fertility is determined to a large extent by the quality (developmental competence) of the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a healthy embryo. Growth of the mammalian oocyte is coordinated with that of the follicle that encloses it by the actions of signals that pass in both directions between the germline and somatic components. This review summarizes what is known about the roles played by 2 different modes of intrafollicular signalling in oogenesis: paracrine factors activating receptors on the opposite cell type, and direct sharing of small molecules throughout the follicle via gap junction channels. Recent evidence indicates that these 2 modes of signalling interact to regulate oocyte growth and granulosa cell proliferation and that defects in either can contribute to female infertility.
Kidder
Gerald M
GM
Departments of Physiology and Pharmacology, Obstetrics and Gynaecology, and Paediatrics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada. gerald.kidder@schulich.uwo.ca
Vanderhyden
Barbara C
BC
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D049109:Cell Proliferation; D005260:Female; D005298:Fertility / Q000502:physiology; D017629:Gap Junctions / Q000502:physiology; D006107:Granulosa Cells / Q000502:physiology*; D006801:Humans; D008297:Male; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D019899:Paracrine Communication; D015398:Signal Transduction