Calcium-dependent control of temporal processing in an auditory interneuron: a computational analysis.
Sensitivity to acoustic amplitude modulation in crickets differs between species and depends on carrier frequency (e.g., calling song vs. bat-ultrasound bands). Using computational tools, we explore how Ca(2+)-dependent mechanisms underlying selective attention can contribute to such differences in amplitude modulation sensitivity. For omega neuron 1 (ON1), selective attention is mediated by Ca(2+)-dependent feedback: [Ca(2+)](internal) increases with excitation, activating a Ca(2+)-dependent after-hyperpolarizing current. We propose that Ca(2+) removal rate and the size of the after-hyperpolarizing current can determine ON1's temporal modulation transfer function (TMTF). This is tested using a conductance-based simulation calibrated to responses in vivo. The model shows that parameter values that simulate responses to single pulses are sufficient in simulating responses to modulated stimuli: no special modulation-sensitive mechanisms are necessary, as high and low-pass portions of the TMTF are due to Ca(2+)-dependent spike frequency adaptation and post-synaptic potential depression, respectively. Furthermore, variance in the two biophysical parameters is sufficient to produce TMTFs of varying bandwidth, shifting amplitude modulation sensitivity like that in different species and in response to different carrier frequencies. Thus, the hypothesis that the size of after-hyperpolarizing current and the rate of Ca(2+) removal can affect amplitude modulation sensitivity is computationally validated.
Ponnath
Abhilash
A
Center for Neuroscience and Kresge Hearing Laboratories, Louisiana State University Health Sciences Center, 2020 Gravier St., New Orleans, LA 70119, USA.
Farris
Hamilton E
HE
D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D006135:Gryllidae / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D008959:Models, Neurological; D008962:Models, Theoretical
D002118:Calcium