title: Neurodevelopment in children with hypoplastic left heart syndrome.
abstract: OBJECTIVE
  To assess neurodevelopment in children with hypoplastic left heart syndrome (HLHS) or other types of functionally single ventricle (univentricular heart, UVH) and to estimate the effect of possible clinical predictors on outcome.
  
  
  METHODS
  A total of 22 patients with HLHS and 14 with UVH, surviving after palliative surgery performed in the same center, and 42 healthy control subjects were examined at a median age of 30.2 months neurologically and according to the Bayley Scales of Infant Development in a population based prospective neurodevelopmental follow-up study.
  
  
  RESULTS
  The mean Mental Developmental Index was significantly lower (89.9) in patients with HLHS than in control subjects (105.5, P<.001), whereas there was no difference between patients with UVH (98.5) and control subjects. The mean Psychomotor Developmental Index in patients with HLHS (80.7, P<.001) as well as in those with UVH (94.5, P=.016) was significantly inferior to that in control subjects (105.3).
  
  
  CONCLUSIONS
  In patients with HLHS, mean Mental Developmental Index lags behind control subjects. Psychomotor Developmental Index is impaired in patients with both HLHS and UVH. Routine neurodevelopmental follow-up is recommended for this seriously ill patient group.
authors.affiliation: Division of Child Neurology, Department of Gynecology and Pediatrics, Helsinki University Central Hospital, Helsinki, Finland. Anne.Sarajuuri@hus.fi
authors.forename: Anne
authors.initials: A
authors.lastname: Sarajuuri
authors.forename: Eero
authors.initials: E
authors.lastname: Jokinen
authors.forename: Riina
authors.initials: R
authors.lastname: Puosi
authors.forename: Leena
authors.initials: L
authors.lastname: Mildh
authors.forename: Ilkka
authors.initials: I
authors.lastname: Mattila
authors.forename: Aulikki
authors.initials: A
authors.lastname: Lano
authors.forename: Tuula
authors.initials: T
authors.lastname: Lönnqvist
mesh_terms: D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000150:complications* / Q000503:physiopathology; D008297:Male; D009420:Nervous System / Q000254:growth & development; D009422:Nervous System Diseases / Q000209:etiology*; D011446:Prospective Studies