title: [First trimester screening for Down syndrome: five years prospective experience].
abstract: First trimester screening for Down syndrome is yet to become the first intention strategy in France. This screening program at 11-14 weeks of gestation using maternal age, fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A has already been validated for a long time by many international studies. It seems to improve detection rate and decrease false positive rates. We report here five years prospective experience.
authors.affiliation: Pôle de gynécologie obstétrique, département d'échographie et de diagnostic anténatal, centre médicochirurgical et obstétrical SIHCUS, 19, rue Louis-Pasteur, 67303 Schiltigheim cedex, France. Anne-Sophie.Weingertner@sihcus.fr
authors.forename: A-S
authors.initials: AS
authors.lastname: Weingertner
authors.forename: N-T
authors.initials: NT
authors.lastname: Trieu
authors.forename: M
authors.initials: M
authors.lastname: Kohler
authors.forename: B
authors.initials: B
authors.lastname: Viville
authors.forename: G
authors.initials: G
authors.lastname: Levy
authors.forename: Y
authors.initials: Y
authors.lastname: Montaya
authors.forename: R
authors.initials: R
authors.lastname: Kutnahorsky
authors.forename: I
authors.initials: I
authors.lastname: Tissier
authors.forename: A
authors.initials: A
authors.lastname: Kohler
authors.forename: M
authors.initials: M
authors.lastname: Tanghe
authors.forename: C
authors.initials: C
authors.lastname: Mager
authors.forename: E
authors.initials: E
authors.lastname: Benassi
authors.forename: M
authors.initials: M
authors.lastname: Cancelier
authors.forename: M
authors.initials: M
authors.lastname: Neuman
authors.forename: N
authors.initials: N
authors.lastname: Bouffet
authors.forename: M C
authors.initials: MC
authors.lastname: Hunsinger
authors.forename: F
authors.initials: F
authors.lastname: Hornecker
authors.forename: B
authors.initials: B
authors.lastname: Langer
authors.forename: I
authors.initials: I
authors.lastname: Nisand
authors.forename: R
authors.initials: R
authors.lastname: Favre
mesh_terms: D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D015337:Multicenter Studies as Topic; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis; D011446:Prospective Studies
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A