[Afobasol antifibrillation activity in animals with the intact and denervated myocardium].
The influence of afobasol on threshold electrical fibrillation of the heart was studied in experiments on narcotized cats. It significantly elevated the cardiac fibrillation threshold in animals with intact myocardium and resembled class 1B anti-arrhythmic drug lidocaine in terms of this activity. Similar results were obtained using cats with denervated myocardium. These observations indicate that in the model of electrical fibrillation of the heart afobasol has marked antifibrillation action mediated through cardiomyocytes. This inference was confirmed by the studies of afobasol effects on cardiac rhythm variability in rats with acute myocardial ischemia. It is supposed that afobasol prevents cardiac fibrillation acting as an agonist of cytosolic sigma-1 receptors in cardiomyocytes
Stoliaruk
V N
VN
Vititnova
M B
MB
Tsorin
I B
IB
Kryzhanovskiĭ
S A
SA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D017763:Autonomic Denervation; D001562:Benzimidazoles / Q000627:therapeutic use*; D002415:Cats; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*; D051381:Rats; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000503:physiopathology
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D000889:Anti-Arrhythmia Agents; D001562:Benzimidazoles; D009025:Morpholines