title: Patients with Acinetobacter baumannii bloodstream infections are colonized in the gastrointestinal tract with identical strains.
abstract: In this study, we identified critically ill patients with Acinetobacter baumannii bacteremia and examined perirectal surveillance cultures for the presence of genetically related A baumannii strains using pulsed-field gel electrophoresis to determine whether gut colonization preceded clinical infection. Seven patients with imipenem-resistant A baumannii bacteremia were identified from January to June of 2008. Six of 7 (86%) patients were colonized in the gastrointestinal tract with genetically similar strains preceding their bacteremia.
authors.affiliation: Division of Healthcare Outcomes Research, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 100 N. Greene Street, Baltimore, MD 21201, USA. kthom@epi.umaryland.edu
authors.forename: Kerri A
authors.initials: KA
authors.lastname: Thom
authors.forename: William W L
authors.initials: WW
authors.lastname: Hsiao
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Harris
authors.forename: O Colin
authors.initials: OC
authors.lastname: Stine
authors.forename: David A
authors.initials: DA
authors.lastname: Rasko
authors.forename: J Kristie
authors.initials: JK
authors.lastname: Johnson
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D001769:Blood / Q000382:microbiology*; D016638:Critical Illness; D003428:Cross Infection / Q000382:microbiology; D016172:DNA Fingerprinting; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem