Effects of the bone marrow microenvironment on hematopoietic malignancy.
The bone marrow (BM) is contained within the bone cavity and is the main site of hematopoiesis, the continuous development of blood cells from immature hematopoietic stem and progenitor cells. The bone marrow consists of developing hematopoietic cells and non-hematopoietic cells, the latter collectively termed the bone marrow microenvironment. These non-hematopoietic cells include cells of the osteoblast lineage, adipocytes and endothelial cells. For many years these bone marrow microenvironment cells were predicted to play active roles in regulating hematopoiesis, and recent studies have confirmed such roles. Importantly, more recent data has indicated that cells of the BM microenvironment may also contribute to hematopoietic diseases. In this review we provide an overview of the roles of the data suggesting that the cells of the bone marrow microenvironment may play an active role in the initiation and progression of hematopoietic malignancy.
Askmyr
Maria
M
St. Vincent's Institute, Fitzroy, Victoria, 3065, Australia.
Quach
Julie
J
Purton
Louise E
LE
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology; D019337:Hematologic Neoplasms / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D023421:Models, Animal; D013234:Stem Cells