title: The effect of trabeculectomy on intraocular pressure of the untreated fellow eye in the collaborative initial glaucoma treatment study.
abstract: OBJECTIVE
  To describe the intraocular pressure (IOP) of the untreated fellow eye after unilateral trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
  
  
  METHODS
  Data collected from a prospective, multicenter, randomized clinical trial.
  
  
  METHODS
  Three hundred patients with newly diagnosed open-angle glaucoma enrolled at 14 centers in the United States who were randomized to initial trabeculectomy.
  
  
  METHODS
  After baseline evaluation and randomization to initial trabeculectomy in the study eye, patients were evaluated at 3 and 6 months and at 6-month intervals thereafter. The IOP was measured by Goldmann applanation tonometry. All eyes included in the analysis were untreated fellow eyes, and the data were censored for potential IOP-lowering events in the fellow eye, including trabeculectomy, argon laser trabeculoplasty, or cataract extraction. Predictive factors for IOP response in the fellow eye to initial trabeculectomy in the study eye were analyzed using a linear mixed model.
  
  
  METHODS
  Intraocular pressure in the untreated fellow eye during follow-up.
  
  
  RESULTS
  Although the IOP in the fellow eye was lower than baseline at 3, 6, 12, 18, and 24 months after trabeculectomy in the study eye, this decrease was statistically significant only at month 12 (mean decrease from baseline, 0.73 ± 3.37 mmHg; P = 0.0134). Predictive associations with higher IOP in the fellow eye during follow-up included higher baseline IOP (P < 0.0001), lower level of education (P = 0.0129), time (P = 0.0005), and the presence of other vascular disease (P = 0.0069). Patients who ultimately required fellow eye trabeculectomy (P < 0.0001) or argon laser trabeculoplasty (P<0.0001), but not cataract extraction (P = 0.4597) in the fellow eye, had lower IOPs during follow-up after these procedures.
  
  
  CONCLUSIONS
  There was no evidence of a substantial effect of trabeculectomy on the IOP of the untreated fellow eye during follow-up. Trabeculectomy does not seem to decrease the mean IOP of the fellow eye, as suggested by some previous studies.
  
  
  BACKGROUND
  Proprietary or commercial disclosure may be found after the references.
authors.affiliation: Weill Cornell Medical College, New York, New York, USA.
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Radcliffe
authors.forename: David C
authors.initials: DC
authors.lastname: Musch
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Niziol
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Liebmann
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D005902:Glaucoma, Open-Angle / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014130:Trabeculectomy