title: Constitutional inv(3) in myelodysplastic syndromes.
abstract: The constitutional pericentric inversion on chromosome 3, inv(3), is rarely found in a normal population. The aim of our study was to investigate its possible link to hematologic malignancy. Chromosomes from bone marrow cells in 890 patients with hematologic disorders were analyzed with the Q-banding technique. Thirty-four patients had inv(3) (3.8%). In 241 patients with myelodysplastic syndromes the frequency was 6.2% as opposed to 2.9% in the remaining 649 patients (p=0.02). The increased frequency of inv(3) in patients with myelodysplastic syndromes indicates that inv(3) could be a risk factor for the development of the disease.
authors.affiliation: Department of Medicine, Karolinska Institutet Huddinge, Stockholm, Sweden.
authors.forename: Caroline
authors.initials: C
authors.lastname: Gahrton
authors.forename: Hareth
authors.initials: H
authors.lastname: Nahi
authors.forename: Monika
authors.initials: M
authors.lastname: Jansson
authors.forename: Ann
authors.initials: A
authors.lastname: Wallblom
authors.forename: Evren
authors.initials: E
authors.lastname: Alici
authors.forename: Tolga
authors.initials: T
authors.lastname: Sutlu
authors.forename: Jan
authors.initials: J
authors.lastname: Samuelsson
authors.forename: Gösta
authors.initials: G
authors.lastname: Gahrton
mesh_terms: D002871:Chromosome Banding; D007446:Chromosome Inversion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D012307:Risk Factors