title: Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, which covers a worldwide geographic area. Demographic and lifestyle characteristics were examined in relation to 25(OH)D using stepwise linear regression and polytomous logistic regression. The prevalence of 25(OH)D concentrations less than 25 nmol/L ranged from 3% to 36% across cohorts, and the prevalence of 25(OH)D concentrations less than 50 nmol/L ranged from 29% to 82%. Seasonal differences in circulating 25(OH)D were most marked among whites from northern latitudes. Statistically significant positive correlates of 25(OH)D included male sex, summer blood draw, vigorous physical activity, vitamin D intake, fish intake, multivitamin use, and calcium supplement use. Significant inverse correlates were body mass index, winter and spring blood draw, history of diabetes, sedentary behavior, smoking, and black race/ethnicity. Correlates varied somewhat within season, race/ethnicity, and sex. These findings help identify persons at risk for low vitamin D status for both clinical and research purposes.
authors.affiliation: American Cancer Society, Atlanta, Georgia 30303-1002, USA. marji.mccullough@cancer.org
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: D Michal
authors.initials: DM
authors.lastname: Freedman
authors.forename: Kathy
authors.initials: K
authors.lastname: Helzlsouer
authors.forename: W Dana
authors.initials: WD
authors.lastname: Flanders
authors.forename: Karen
authors.initials: K
authors.lastname: Koenig
authors.forename: Laurence
authors.initials: L
authors.lastname: Kolonel
authors.forename: Francine
authors.initials: F
authors.lastname: Laden
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Mark
authors.initials: M
authors.lastname: Purdue
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Stevens
authors.forename: Rachael
authors.initials: R
authors.lastname: Stolzenberg-Solomon
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Jason
authors.initials: J
authors.lastname: Ashby
authors.forename: Kimberly
authors.initials: K
authors.lastname: Bertrand
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Lisa
authors.initials: L
authors.lastname: Gallicchio
authors.forename: Edward
authors.initials: E
authors.lastname: Giovannucci
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Jacobs
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Virginia
authors.initials: V
authors.lastname: Hartmuller
authors.forename: Chinonye
authors.initials: C
authors.lastname: Harvey
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D008297:Male; D009369:Neoplasms / Q000208:ethnology / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D011446:Prospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology* / Q000208:ethnology / Q000517:prevention & control
chemical_list: D014807:Vitamin D