Th17 and regulatory T cells: implications for AIDS pathogenesis.
OBJECTIVE
The present review discusses recent reports showing that reciprocal changes in T helper interleukin-17-secreting CD4 Th17 cells and CD4CD25FoxP3 regulatory T cells (Tregs) may play a role in the progressive disease caused by the HIV and by simian immunodeficiency virus.


RESULTS
Studies in nonhuman primate models of lentiviral infection and in HIV-infected human individuals have shown that pathogenic infection is associated with loss of Th17 cells and an increase in the frequency of Tregs. Because interleukin-17 serves to maintain the integrity of the mucosal barrier, loss of Th17 cells may permit the increase in microbial translocation across the gastrointestinal mucosa that is observed in pathogenic lentiviral disease. It remains unclear, however, whether Th17 cells are preferentially infected or if, instead, their loss is induced by bystander effects of lentiviral infection, for example, the induction of indoleamine 2,3-dioxygenase.


CONCLUSIONS
Progressive lentiviral disease is associated with preferential depletion of Th17 cells and loss of Th17/Treg balance. Further analysis of such changes in the composition of subset CD4 T helper and Tregs may shed new light on the immunopathology of HIV disease and suggest new strategies for therapeutic and preventive interventions.
Kanwar
Bittoo
B
Division of Experimental Medicine, Department of Medicine, University of California-San Francisco, CA 94110, USA.
Favre
David
D
McCune
Joseph M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology*; D000818:Animals; D001419:Bacteria / Q000276:immunology; D018988:Bacterial Translocation; D006678:HIV / Q000276:immunology / Q000472:pathogenicity; D000882:Haplorhini; D006801:Humans; D018928:Immunity, Mucosal; D020381:Interleukin-17 / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000472:pathogenicity; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D020381:Interleukin-17