[UV radiation and skin pigmentation. Aryl hydrocarbon receptor - a "new kid on the block"].
UV radiation is the most important modulator of skin pigmentation. In this article we report on novel studies which show that the aryl hydrocarbon receptor, which can be activated by UV-generated photoproducts, mediates a substantial part of UVB-induced skin pigmentation reaction. This newly discovered mechanism opens interesting possibilities for cosmetic and therapeutic treatment of pigment disorders.
Esser
C
C
Leibniz-Institut für Umweltmedizinische Forschung gGmbH, Heinrich-Heine-Universität Düsseldorf, Auf'm Hennekamp 50, 40225, Düsseldorf, Deutschland. chesser@uni-duesseldorf.de
Krutmann
J
J
D000818:Animals; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism* / Q000528:radiation effects*; D012880:Skin Pigmentation / Q000502:physiology* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D018336:Receptors, Aryl Hydrocarbon