title: Effect of medication on microvascular vasodilatation in patients with systemic lupus erythematosus.
abstract: The aim of this study was to investigate the microvascular responses in the skin, to local heat, iontophoretically administered acetylcholine and to sodium nitroprusside in relation to cardiovascular damage in patients with systemic lupus erythematosus (SLE) and matched controls. We also wanted to examine if the ongoing medication in SLE patients influenced this vascular response. We investigated 30 women with SLE and compared them with 20 age and sex-matched controls. The cutaneous blood flow response to local heat (+44°C), iontophoretically administered endothelium-dependent (acetylcholine), as well as independent (sodium nitroprusside) vasodilatation, was measured by laser Doppler flowmetry. Clinical data and medication were retrieved from the clinical database and patient records. The cutaneous microvascular reactivity did not differ between SLE patients and a group of matched controls nor did it correlate with cardiovascular damage [assessed by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI)]. However, patients on antimalarial drugs (hydroxychloroquine n = 8 and chloroquine diphosphate n = 3) responded more strongly to sodium nitroprusside (endothelium-independent vasodilatation) compared with those without antimalarial drugs (p < 0.01). The response to acetylcholine was higher among patients on warfarin compared with those without (p < 0.05), whereas glucocorticoid use (≥5 mg daily) was associated with reduced response to acetylcholine (p < 0.05). Smokers in general tended to have a lower response to acetylcholine (p = 0.064). Smoking SLE patients versus non-smoking SLE patients had a significantly lower response to acetylcholine (p = 0.01). Medication with antimalarial drugs-enhanced endothelium-independent vasodilatation, while glucocorticoid use was associated with reduction and warfarin-treatment with enhancement of endothelium-dependent vasodilatation. Therefore, despite there is no difference in microvascular endothelium-dependent vasodilatation, other factors such as medication and smoking may affect vasodilatation in SLE patients.
authors.affiliation: Department of Rheumatology, Östersund Hospital, Östersund, Sweden. christine.bengtsson@jll.se
authors.forename: Christine
authors.initials: C
authors.lastname: Bengtsson
authors.forename: Sven E
authors.initials: SE
authors.lastname: Andersson
authors.forename: Lars
authors.initials: L
authors.lastname: Edvinsson
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Edvinsson
authors.forename: Gunnar
authors.initials: G
authors.lastname: Sturfelt
authors.forename: Ola
authors.initials: O
authors.lastname: Nived
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D016022:Case-Control Studies; D004347:Drug Interactions; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D009599:Nitroprusside / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012867:Skin / Q000098:blood supply / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D044465:White People
chemical_list: D000962:Antimalarials; D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine