Moyamoya in a child treated with interferon for recurrent osteosarcoma.
Moyamoya is a cerebral vasculopathy of unknown etiology rarely described as a late effect after the treatment of childhood cancer. We describe a 12-year-old female who developed moyamoya after the completion of systemic chemotherapy, surgery, and adjuvant interferon alpha for osteosarcoma with pulmonary metastases. Given the importance of characterizing late effects after the treatment of childhood cancer, the potential role of interferon alpha in the development of moyamoya is discussed.
Buchbinder
David
D
Division of Hematology, Department of Pediatrics, Children's Hospital of Orange County, Main Street, Orange, USA. dbuchbinder@choc.org
Steinberg
Gary
G
Linetsky
Michael
M
Casillas
Jacqueline
J
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002340:Carotid Artery Diseases / Q000139:chemically induced / Q000473:pathology; D002539:Cerebral Arterial Diseases / Q000139:chemically induced / Q000473:pathology; D002544:Cerebral Infarction / Q000139:chemically induced / Q000473:pathology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D016898:Interferon-alpha / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D018810:Magnetic Resonance Angiography; D008727:Methotrexate / Q000008:administration & dosage; D009072:Moyamoya Disease / Q000139:chemically induced* / Q000473:pathology; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012516:Osteosarcoma / Q000188:drug therapy* / Q000556:secondary; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced
D000970:Antineoplastic Agents; D016898:Interferon-alpha; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate