Acute ototoxicity from a single infusion of oxaliplatin.
Ototoxicity secondary to the administration of the chemotherapeutic agent oxaliplatin is uncommon. We report a case of unilateral hearing loss that occurred immediately after the infusion of a single dose of oxaliplatin in a 70-year-old woman who was undergoing postoperative chemotherapy for rectal adenocarcinoma. To the best of our knowledge, no such case has been previously reported in the literature. The hearing loss in our patient was severe enough to limit her daily activities, and she experienced only minimal improvement during the next 2 years of follow-up.
Malhotra
Narinder K
NK
Regional Cancer Center, 5476 Pepperwood Circle, Erie, PA 16506, USA. pghmd02@aol.com
Aslam
Rizwan
R
Lipman
Sydney P
SP
Bilski
Vicki J
VJ
D000208:Acute Disease; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D046088:Hearing Loss, Unilateral / Q000139:chemically induced*; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin; D012004:Rectal Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin