Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.
We report the efficient synthesis and biological evaluation of new benzodioxinoindolocarbazoles heterocycles (BDCZs) designed as potential anticancer agents. Indolic substitution and maleimide variations were performed to design a new library of BDCZs and their cytotoxicity were evaluated on two representative cancer cell lines. Several derivatives have shown a marked cytotoxicity with IC(50) values in the nanomolar range. Results are reported in this Letter.
Ayerbe
Nathalie
N
Institut de Chimie Organique et Analytique, UMC CNRS 6005, Orléans cedex 2, France.
Routier
Sylvain
S
Gillaizeau
Isabelle
I
Maiereanu
Carmen
C
Caignard
Daniel-Henry
DH
Pierré
Alain
A
Léonce
Stéphane
S
Coudert
Gérard
G
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D002227:Carbazoles