title: Survival of Burkholderia cepacia sepsis following lung transplantation in recipients with cystic fibrosis.
abstract: Cystic fibrosis (CF) lung transplant recipients infected with Burkholderia cenocepacia have a worse survival rate after lung transplantation than those who are not infected with this organism. The decreased survival is predominantly due to recurrent B. cenocepacia infection, with the majority of affected recipients succumbing within 3 months after transplant. B. cepacia complex (BCC) sepsis is one of the defining criteria for cepacia syndrome, an almost universally fatal necrotizing pneumonic illness. We report 2 CF patients who were long-term survivors of B. cenocepacia sepsis after lung transplantation. The aim of this report is to demonstrate that, although survival of B. cenocepacia sepsis after lung transplantation is extremely uncommon, with aggressive multidisciplinary management, long-term survival remains a realistic objective.
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Canada. edward.nash@heartofengland.nhs.uk
authors.forename: E F
authors.initials: EF
authors.lastname: Nash
authors.forename: A
authors.initials: A
authors.lastname: Coonar
authors.forename: R
authors.initials: R
authors.lastname: Kremer
authors.forename: E
authors.initials: E
authors.lastname: Tullis
authors.forename: M
authors.initials: M
authors.lastname: Hutcheon
authors.forename: L G
authors.initials: LG
authors.lastname: Singer
authors.forename: S
authors.initials: S
authors.lastname: Keshavjee
authors.forename: C
authors.initials: C
authors.lastname: Chaparro
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019121:Burkholderia Infections / Q000382:microbiology / Q000401:mortality* / Q000601:surgery; D042602:Burkholderia cepacia complex / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D016724:Empyema, Pleural / Q000382:microbiology / Q000601:surgery; D005260:Female; D006801:Humans; D008168:Lung / Q000601:surgery; D008169:Lung Abscess / Q000382:microbiology / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality* / Q000601:surgery; D015996:Survival Rate; D017741:Survivors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents