Clickable peptide nucleic acids (cPNA) with tunable affinity.
Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a "click" cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments.
Chouikhi
Dalila
D
Institut de Science et Ingénierie Supramoléculaires (ISIS-UMR 7006)Université de Strasbourg-CNRS, 8 allée Gaspard Monge, F67000 Strasbourg, France.
Barluenga
Sofia
S
Winssinger
Nicolas
N
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D003500:Cyclization; D004247:DNA / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D020135:Peptide Nucleic Acids; D014230:Triazoles; D004247:DNA