title: Tuberculosis research update.
abstract: Tuberculosis (TB) remains a major challenge to global public health in the 21st century. In 2007, there were an estimated 9.27 million new cases and 1.3 million deaths among HIV-negative patients with TB. The HIV-associated TB epidemic, drug-resistant disease, the need for better diagnostic assays and the limited efficacy of Bacille Calmette-Guerin vaccination are four important obstacles to further progress in global TB control. In this brief review, we provide a focused update on these four key areas of TB research.
authors.affiliation: South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa. willem.hanekom@uct.ac.za
authors.forename: W A
authors.initials: WA
authors.lastname: Hanekom
authors.forename: S D
authors.initials: SD
authors.lastname: Lawn
authors.forename: K
authors.initials: K
authors.lastname: Dheda
authors.forename: A
authors.initials: A
authors.lastname: Whitelaw
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000628:therapy; D019380:Anti-HIV Agents / Q000627:therapeutic use; D006801:Humans; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D032581:Tuberculosis Vaccines; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000628:therapy
chemical_list: D019380:Anti-HIV Agents; D032581:Tuberculosis Vaccines