title: Implantable device therapy for the treatment of resistant hypertension.
abstract: The prevalence of resistant hypertension continues to increase and the standard approaches of therapeutic lifestyle changes and drug therapy are ineffective in bringing many of these patients to goal blood pressure. Electrical stimulation of the carotid sinus baroreceptor through a surgically implanted device is presently under clinical investigation and is showing some encouraging early results. This review discusses the evolution of this therapy including a review of the current data available from the early stages of ongoing clinical trials.
authors.affiliation: Department of Internal Medicine, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Joshi
authors.forename: Jeremy
authors.initials: J
authors.lastname: Taylor
authors.forename: John D
authors.initials: JD
authors.lastname: Bisognano
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D017704:Baroreflex; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D004351:Drug Resistance; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004567:Electrodes, Implanted; D004867:Equipment Design; D019317:Evidence-Based Medicine; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D011311:Pressoreceptors / Q000503:physiopathology*; D017211:Treatment Failure
chemical_list: D000959:Antihypertensive Agents