title: Mannitol-induced acute renal failure.
abstract: A 62-year-old man was admitted to the ophthalmologic department for operation of retinal detachment. Mannitol and acetazolamide were prescribed to reduce intraocular pressure. Seven days after operation, gradual onset of drowsy consciousness occurred. The laboratory findings of hypertonic hyponatremia (109 mEq/l), hyperosmolality (341 mosm/kg), metabolic acidosis (pH: 7.17) and acute renal failure (serum creatinine: 8.2 mg/dl) dictated a diagnosis of mannitol-induced acute kidney injury. First, 3% saline was given, but consciousness kept deteriorated with worsened dyspnea and metabolic acidosis. Hemodialysis was then performed subsequently and his consciousness and renal function completely recovered. A special emphasis on the treatment of hypertonic hyponatremia was given.
authors.affiliation: Department of Medicine, Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: S-F
authors.initials: SF
authors.lastname: Tsai
authors.forename: K-H
authors.initials: KH
authors.lastname: Shu
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy*; D004234:Diuretics, Osmotic / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008353:Mannitol / Q000009:adverse effects*; D008875:Middle Aged; D006435:Renal Dialysis; D012163:Retinal Detachment / Q000601:surgery
chemical_list: D004234:Diuretics, Osmotic; D008353:Mannitol