MicroRNA-21 in cardiovascular disease.
MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular system. Recent studies have revealed that its expression is deregulated in heart and vasculature under cardiovascular disease conditions such as proliferative vascular disease, cardiac hypertrophy and heart failure, and ischemic heart disease. miR-21 is found to play important roles in vascular smooth muscle cell proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. Accordingly, miR-21 is proven to be involved in the pathogenesis of the above-mentioned cardiovascular diseases as demonstrated by both loss-of-function and gain-of-function approaches. Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects. miR-21 might be a novel therapeutic target in cardiovascular diseases. This review article summarizes the research progress regarding the roles of miR-21 in cardiovascular disease.
Cheng
Yunhui
Y
RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB-E548, Newark, NJ 07101, USA.
Zhang
Chunxiang
C
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D006332:Cardiomegaly / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000235:genetics; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics*
C524940:MIRN21 microRNA, human; D035683:MicroRNAs