title: Holmium-161 produced using 11.6 MeV protons: A practical source of narrow-band X-rays.
abstract: We present a novel technique to produce narrow-band X-rays by preparing (161)Ho from the bombardment of dysprosium foil by 11.6 MeV protons. The activated foil produces predominantly 45-55 keV X-rays, which are suitable for activating iodinated radio-sensitizing agents (e.g. IUdR) for oncological therapy. We demonstrate that clinically useful quantities of the nuclide are easily produced with a medical cyclotron which is far from the current state of the art.
authors.affiliation: Department of Physics, Vanderbilt University, 6301 Stevenson Center, P.O. Box 351807 Station B, Nashville, TN 37235, USA.
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Stephens
authors.forename: Marcus H
authors.initials: MH
authors.lastname: Mendenhall
mesh_terms: D006695:Holmium; D008495:Medical Oncology / Q000379:methods; D008722:Methods; D009369:Neoplasms / Q000532:radiotherapy; D011522:Protons; D011827:Radiation; D011868:Radioisotopes; D011878:Radiotherapy / Q000379:methods*; D014965:X-Rays
chemical_list: D011522:Protons; D011868:Radioisotopes; D006695:Holmium