title: Total neuron numbers in CA1-4 sectors of the dog hippocampus.
abstract: OBJECTIVE
  Early reports addressed morphological asymmetry in the cross-sectional width of the rat hippocampus. The present study was aimed at counting total number of neurons in CA1-4 sectors and the subiculum of the dog hippocampus as well as investigating possible left /right and male/female asymmetry.
  
  
  METHODS
  Adult mongrel dogs (8 female and 5 male) were assessed by the right and left pawedness and sacrificed by exsanguinations. In each hippocampus dissected, the total neuron numbers of CAs and subiculum were estimated by the physical fractioning method.
  
  
  RESULTS
  Significant hemispheric asymmetries were found in the number of pyramidal cells of CA1, CA3/2, CA4 and the subiculum. Sex difference was also found in the subiculum, in favour of the males.
  
  
  CONCLUSIONS
  Our study indicated a left dominant asymmetry in males and right dominancy in females as well as no functional asymmetry in specific regions of the dog hippocampus. Further investigations are necessary to verify the hypothesis that hippocampal morphological asymmetries in normal subjects are functionally related in memory or in cognitive skills.
authors.affiliation: Departments of Histology & Embryology , Medical Faculty, Yüzüncü Yil University,Van, Turkey.
authors.forename: Murat Cetin
authors.initials: MC
authors.lastname: Rağbetli
authors.forename: Atif
authors.initials: A
authors.lastname: Aydinlioğlu
authors.forename: Necat
authors.initials: N
authors.lastname: Koyun
authors.forename: Recep
authors.initials: R
authors.lastname: Yayici
authors.forename: Kadir
authors.initials: K
authors.lastname: Arslan
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002452:Cell Count; D004285:Dogs; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000033:anatomy & histology*; D008297:Male; D009474:Neurons / Q000166:cytology*; D051381:Rats; D012727:Sex Characteristics