title: Malakite: an automatic tool for characterisation of structure of reliable blocks in multiple alignments of protein sequences.
abstract: It makes sense to speak of alignment of protein sequences only within the regions, where the sequences are related to each other. This simple consideration is often disregarded by programs of multiple alignment construction. A package for alignment analysis MAlAKiTE (Multiple Alignment Automatic Kinship Tiling Engine) is introduced. It aims to find the blocks of reliable alignment, which contain related regions only, within the whole alignment and allows for dealing with them. The validity of the detection of reliable blocks' was verified by comparison with structural data.
authors.affiliation: Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia. BurkovBA@gmail.com
authors.forename: Boris
authors.initials: B
authors.lastname: Burkov
authors.forename: Boris
authors.initials: B
authors.lastname: Nagaev
authors.forename: Sergei
authors.initials: S
authors.lastname: Spirin
authors.forename: Andrei
authors.initials: A
authors.lastname: Alexeevski
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software
chemical_list: D011506:Proteins