title: [Post-modification oxygenases in the biosynthesis of aromatic polyketides--a review].
abstract: Oxygenases are common tailoring enzymes involved in the biosynthesis of aromatic polyketides, they are critical determinants of the final structure of aromatic polyketides. Here we review the structures and functions of several classes of oxygenases found in the biosynthetic gene clusters of aromatic polyketides. We used the oxygenases (JadFGH) in jadomycin biosynthesis as examples to elucidate the complex roles these oxygenases play and discussed the future prospects of using oxygenases in combinatorial biosynthesis.
authors.affiliation: Shandong Normal University, Jinan 250014, China. jijunjie_2004@163.com
authors.forename: Junjie
authors.initials: J
authors.lastname: Ji
authors.forename: Keqiang
authors.initials: K
authors.lastname: Fan
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Peng
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Tian
authors.forename: Meixue
authors.initials: M
authors.lastname: Dai
authors.forename: Keqian
authors.initials: K
authors.lastname: Yang
mesh_terms: D024322:Amino Acids, Aromatic / Q000096:biosynthesis*; D007546:Isoquinolines / Q000737:chemistry; D018942:Macrolides / Q000378:metabolism*; D010105:Oxygenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
chemical_list: D024322:Amino Acids, Aromatic; D007546:Isoquinolines; D018942:Macrolides; C081750:jadomycin B; D010105:Oxygenases