Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by Cryptococcus gattii.
Cryptococcosis caused by Cryptococcus gattii is a devastating disease of immunocompetent hosts with an incompletely understood pathogenesis. Utilizing an immunoproteomic approach in a naturally occurring koala model of disease, a number of key proteins and pathways are identified in the early and late pathogenesis of cryptococcosis for the first time. In particular, the thioredoxin system appears important in the pathogenesis of cryptococcosis caused by C. gattii VGII.
Jobbins
Sarah E
SE
The Faculty of Veterinary Science, the University of Sydney, Australia.
Hill
Cameron J
CJ
D'Souza-Basseal
Jocelyn M
JM
Padula
Matthew P
MP
Herbert
Ben R
BR
Krockenberger
Mark B
MB
D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood / Q000276:immunology*; D000946:Antigens, Fungal / Q000276:immunology / Q000302:isolation & purification*; D001315:Australia; D003453:Cryptococcosis / Q000276:immunology / Q000503:physiopathology*; D056285:Cryptococcus gattii / Q000235:genetics / Q000276:immunology*; D015180:Electrophoresis, Gel, Two-Dimensional; D015151:Immunoblotting; D048368:Phascolarctidae / Q000276:immunology / Q000382:microbiology*; D040901:Proteomics / Q000379:methods*
D000908:Antibodies, Fungal; D000946:Antigens, Fungal