title: The potential value of Clostridium difficile vaccine: an economic computer simulation model.
abstract: Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.
authors.affiliation: Applied Modeling, Public Health Computational and Operations Research Group (PHICOR), Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu
authors.forename: Bruce Y
authors.initials: BY
authors.lastname: Lee
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Popovich
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Bailey
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Ufberg
authors.forename: Ann E
authors.initials: AE
authors.lastname: Wiringa
authors.forename: Robert R
authors.initials: RR
authors.lastname: Muder
mesh_terms: D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000191:economics; D016360:Clostridioides difficile; D003198:Computer Simulation; D003362:Cost-Benefit Analysis; D004761:Enterocolitis, Pseudomembranous / Q000517:prevention & control*; D006801:Humans; D018803:Models, Economic; D009010:Monte Carlo Method; D012307:Risk Factors; D055502:Secondary Prevention
chemical_list: D001428:Bacterial Vaccines