title: A Biomimetic Material with a High Bio-responsibility for Bone Reconstruction and Tissue Engineering.
abstract: A biomimetic composite was prepared using type-I collagen as the matrix, and particles of sol-gel-derived bioactive glass (58S), hyaluronic acid and phosphatidylserine as additives. The material has an interconnected 3-D porous structure with a porosity > 85%. When incubated in simulated body fluid (SBF), the composite induced the formation of microcrystals of bone-like hydroxyapatite (HA), suggesting good bioactive properties. During the in vitro cell-culture experiment, MC3T3-E1 cells adhered to, migrated and spread on the surface of the porous composite. The material was employed to repair a 10-mm defect in a rabbit's radius. The composite was gradually degraded within 8 weeks and replaced by new bone. After 12 weeks, the bone marrow cavity was restored and the Haversian canal was noted from the histological observation. The biomimetic composite is a potential scaffold material for bone reconstruction and bone tissue engineering.
authors.affiliation: a Biomaterials Research Institute, College of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, P. R. China; The Key Laboratory of Specially Functional Materials, Ministry of Education, South China University of Technology, Guangzhou, Guangdong 510640, P. R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Meng
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Chang
authors.initials: C
authors.lastname: Du
authors.forename: Chunrong
authors.initials: C
authors.lastname: Yang
mesh_terms: D016475:3T3 Cells; D020341:Absorbable Implants; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D002113:Calcification, Physiologic; D002448:Cell Adhesion; D002465:Cell Movement; D004195:Disease Models, Animal; D017886:Durapatite / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D011817:Rabbits; D011884:Radius / Q000293:injuries; D013057:Spectrum Analysis; D023822:Tissue Engineering / Q000295:instrumentation; D054457:Tissue Scaffolds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes; D017886:Durapatite