Hospitalization for osteoarthritis and prostate cancer specific mortality among Swedish men with prostate cancer.
OBJECTIVE
To examine the potential role of nonsteroidal anti-inflammatory drugs (NSAIDs) use on prostate cancer (PCa) specific mortality.


METHODS
We studied the association between hospitalization for osteoarthritis prior to PCa diagnosis, as a surrogate for heavy use of NSAIDs, and PCa specific mortality in a large population of PCa patients in Sweden in 1980-2004.


RESULTS
Hospitalization for osteoarthritis before PCa diagnosis was associated to a lower PCa specific mortality (hazard ratio [HR], 0.92; 95% confidence interval [CI], 0.88-0.96), but not to the risk of death from other causes (HR, 1.03; 95% CI, 0.99-1.08). The association was stronger among younger patients and patients diagnosed in earlier calendar years.


CONCLUSIONS
Our data demonstrate a modestly decreased PCa specific mortality among PCa patients with hospitalization for osteoarthritis prior to PCa diagnosis, compared to those without such experience. This finding lends support to the hypothesis that NSAIDs use may influence PCa progression.
Fang
Fang
F
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm 171 77, Sweden. Fang.Fang@ki.se
Valdimarsdóttir
Unnur
U
Mucci
Lorelei
L
Sparén
Pär
P
Ye
Weimin
W
Fall
Katja
K
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy / Q000453:epidemiology*; D011471:Prostatic Neoplasms / Q000401:mortality*; D012042:Registries; D013548:Sweden / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal