Phospholipase A2 and arachidonic acid in Alzheimer's disease.
Essential fatty acids (EFA) play a critical role in the brain and regulate many of the processes altered in Alzheimer's disease (AD). Technical advances are allowing for the dissection of complex lipid pathways in normal and diseased states. Arachidonic acid (AA) and specific isoforms of phospholipase A(2) (PLA(2)) appear to be critical mediators in amyloid-beta (Abeta)-induced pathogenesis, leading to learning, memory, and behavioral impairments in mouse models of AD. These findings and ongoing research into lipid biology in AD and related disorders promise to reveal new pharmacological targets that may lead to better treatments for these devastating conditions.
Sanchez-Mejia
Rene O
RO
Scripps Clinic and The Scripps Research Institute, La Jolla, CA 92037, USA.
Mucke
Lennart
L
D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism / Q000502:physiology*; D055808:Drug Discovery; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D054467:Phospholipases A2 / Q000378:metabolism / Q000502:physiology*
D016229:Amyloid beta-Peptides; D016718:Arachidonic Acid; D054467:Phospholipases A2