Optimal management of chronic graft-versus-host disease in children.
Chronic graft-versus-host disease (GVHD) is a major complication after allogeneic haematopoietic stem cell transplantation (HSCT). Not only is it the major cause of late mortality in HSCT patients, but it also accounts for significant morbidity. Much of the literature on chronic GVHD has focused on adults. Chronic GVHD is of major importance in children, especially since they have years to live following the complications of chronic GVHD and its therapy. The goal is to review incidence, manifestations, and therapies, especially when applicable to the paediatric population.
Jacobsohn
David A
DA
Children's National Medical Center, Washington, DC 20010, USA. djacobso@cnmc.org
D002648:Child; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D016879:Salvage Therapy / Q000379:methods