Calcium phosphate biomaterials as bone drug delivery systems: a review.
A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems. In the first part, a brief update is given on the performance of both CaP ceramics and CaP cements. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems. Experimental works performed for local delivery are reported. In particular, a description is given of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs.
Verron
Elise
E
PRES UNAM, INSERM UMR, LIOAD, Nantes, France.
Khairoun
Ibrahim
I
Guicheux
Jerome
J
Bouler
Jean-Michel
JM
D000818:Animals; D001842:Bone and Bones; D002130:Calcium Phosphates / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000009:adverse effects; D006801:Humans
D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D004337:Drug Carriers