title: [A case of recurrence with liver metastasis after total gastrectomy for StageIA gastric carcinoma successfully treated with S-1/CDDP combination followed by S-1 chemotherapy].
abstract: A 72-year-old man underwent total gastrectomy for gastric carcinoma. Postoperative staging was Stage IA. One year after operation, abdominal CT revealed a metastatic tumor in the left lateral posterior segment of the liver. He was given S-1/ CDDP combination chemotherapy(S-1 120mg/body, day 1-21, CDDP 95mg/body, day 8)every 5weeks as first-line treatment. After 2 courses of the treatment, the liver tumor was not detected by PET-CT. The clinical response was assessed to be complete response. After total 5 courses of the treatment, we changed to a single administration of S-1(120mg/body, day 1- 14)every 3 or 4 weeks as second-line chemotherapy. The effect has been continued for 18 months after the initial metastasis. S-1/CDDP and S-1 chemotherapy are effective for metachronous liver metastasis from gastric carcinoma, although prognosis of the disease is poor.
authors.affiliation: Department of Surgery, Nagano Matsushiro General Hospita.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: Kikuo
authors.initials: K
authors.lastname: Aizawa
authors.forename: Saori
authors.initials: S
authors.lastname: Muramatsu
authors.forename: Akimasa
authors.initials: A
authors.lastname: Matsushita
authors.forename: Toshinari
authors.initials: T
authors.lastname: Kumaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kasuga
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin