title: Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder.
abstract: BACKGROUND
  Obsessive-compulsive disorder (OCD) is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome), suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients.
  
  
  METHODS
  We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA).
  
  
  RESULTS
  No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients.
  
  
  CONCLUSIONS
  Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.
authors.affiliation: INSERM, U955, Institut Mondor de Recherche Biomédicale, PsychiatricGenetics, Créteil, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Delorme
authors.forename: Daniel
authors.initials: D
authors.lastname: Moreno-De-Luca
authors.forename: Aurélie
authors.initials: A
authors.lastname: Gennetier
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Pauline
authors.initials: P
authors.lastname: Chaste
authors.forename: Rainald
authors.initials: R
authors.lastname: Mössner
authors.forename: Hans Jörgen
authors.initials: HJ
authors.lastname: Grabe
authors.forename: Stephan
authors.initials: S
authors.lastname: Ruhrmann
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Mouren
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.forename: Catalina
authors.initials: C
authors.lastname: Betancur
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D056915:DNA Copy Number Variations; D004062:DiGeorge Syndrome / Q000150:complications / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000235:genetics*; D011218:Prader-Willi Syndrome / Q000150:complications / Q000235:genetics; D056916:Segmental Duplications, Genomic; D017384:Sequence Deletion; D013577:Syndrome; D055815:Young Adult