title: Anterior temporal lobectomy combined with anterior corpus callosotomy in patients with temporal lobe epilepsy and mental retardation.
abstract: OBJECTIVE
  To investigate the surgical outcomes of anterior corpus callosotomy (aCCT) combined with anterior temporal lobectomy (ATL) in patients with intractable temporal lobe epilepsy (TLE) and mental retardation (MR).
  
  
  METHODS
  Sixty patients with TLE and MR were carefully selected and randomly divided into two equal groups: ATL and aCCT, in which they were treated with ATL or ATL combined with aCCT, respectively. Surgical outcomes, including seizure control, IQ and quality of life (QOL) changes, as well as complications were recorded and analyzed 2 years after operation.
  
  
  RESULTS
  Seizure-free status had been achieved in 66.7% of all patients. The aCCT group had higher percentage in Engle Classes I-II than the ATL group (96.7% vs. 80.0%, P<0.05). 56.7% of patients in ATL group and 63.3% in aCCT group had improved full scale IQ (FIQ) after surgery, while the decline of FIQ in aCCT group was less than that of ATL group (3.3% vs. 30.0%). Compared with pre-operative score, the mean post-operative score of performance IQ in aCCT group had improved. Significant difference in QOL change had been found between two groups (P<0.001). 73.7% of patients in aCCT group had their QOL improved with no long-term complications.
  
  
  CONCLUSIONS
  ATL combined with aCCT can improve QOL and performance IQ in patients with TLE and MR.
authors.affiliation: Department of Neurosurgery, Capital Epilepsy Therapy Center, First Affiliated Hospital of General Hospital of Chinese People's Liberation Army, Beijing, China. liangsl_304@sina.com
authors.forename: Shuli
authors.initials: S
authors.lastname: Liang
authors.forename: Anmin
authors.initials: A
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Xiaolun
authors.initials: X
authors.lastname: Meng
authors.forename: Yajing
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects; D002648:Child; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D007361:Intelligence Tests; D008297:Male; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult