Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-<75 nmol/L, no statistically significant associations were observed for <37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87, 1.70), 37.5-<50 (OR = 1.03, 95% CI: 0.75, 1.41), or > or =75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index of > or =25 kg/m(2) (P(interaction) < 0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women.
Zheng
Wei
W
Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA. wei.zheng@vanderbilt.edu
Danforth
Kim N
KN
Tworoger
Shelley S
SS
Goodman
Marc T
MT
Arslan
Alan A
AA
Patel
Alpa V
AV
McCullough
Marjorie L
ML
Weinstein
Stephanie J
SJ
Kolonel
Laurence N
LN
Purdue
Mark P
MP
Shu
Xiao-Ou
XO
Snyder
Kirk
K
Steplowski
Emily
E
Visvanathan
Kala
K
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
Gao
Yu-Tang
YT
Hankinson
Susan E
SE
Harvey
Chinonye
C
Hayes
Richard B
RB
Henderson
Brian E
BE
Horst
Ronald L
RL
Helzlsouer
Kathy J
KJ
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D050177:Overweight / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
D014807:Vitamin D