[Natural course of aortic valve stenosis in patients with normal and abnormal lipid profile].
OBJECTIVE
Comparison of echocardiographic findings in AVS patients with and without hypercholesterolemia during 12 months' observation of AVS natural course.


METHODS
60 AVS patients who did not agree for operational treatment were divided into group A (n = 47) with high serum total cholesterol and into group B (n = 13) with normal plasma cholesterol.


METHODS
plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, tri-glycerides and lipoprotein (a) were measured every 12 months and echocardiographic evaluation of aortic valve was also done every 12 months.


RESULTS
Means total cholesterol did not change in group A, while increased in group B. HDL-cholesterol decreased in group A and LDL-cholesterol increased in group B. Mean TG and Lp(a) levels did not change in both groups. Increase in AOG max and AOG mean as well as V max were found only group A. LVPW syst increase was found in group A. LA diameter increased and AVA decreased only in group A.


CONCLUSIONS
The results may suggest risk factors similarity of AVS progression and atherosclerosis.
Swierszcz
Jolanta
J
II Klinika Kardiologii Collegium Medicum, Uniwersytetu Jagiellońskiego. grasshoppers@interia.eu
Dubiel
Jacek S
JS
Milewicz
Tomasz
T
Sztefko
Krystyna
K
Galicka-Latała
Danuta
D
Pfitzner
Roman
R
Wodniecki
Jan
J
Krzysiek
Józef
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D050356:Lipid Metabolism; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol