title: Hydrogen-ion potential of antibiotics according to the environment factors temperature and luminosity.
abstract: The objective of this experimental study was to measure the pH of antibiotics administered by intravenous infusion--ceftriaxone sodium, vancomycin hydrochloride, metrodinazole, penicillin G potassium and amikacin sulfate--after reconstitution with sterile water and dilution with NaCl 0.9% or dextrose 5% in water, according to temperature and luminosity of the environment. The results showed that variation in the drugs' pH was less than 1.0 value and that some antibiotics remained acidic after dilution and maintained this chemical profile in all situations studied, suggesting that the studied environmental factors did not change the solutions' acid base characteristic. Some pH values measured characterize risk for the development of chemical phlebitis and infiltration, and it is important for clinical practice to emphasize the profile of intravenous solutions of antibiotics, considering method of dilution, and time to infusion.
authors.affiliation: Departamento de Enfermagem, Universidade Federal de São Paulo, SP, Brazil.
authors.forename: Renata Maria Coelho
authors.initials: RM
authors.lastname: Crepaldi
authors.forename: Cíntia
authors.initials: C
authors.lastname: Monteiro
authors.forename: Maria Angélica Sorgini
authors.initials: MA
authors.lastname: Peterlini
authors.forename: Mavilde da Luz Gonçalves
authors.initials: Mda L
authors.lastname: Pedreira
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008027:Light; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents