Syntheses of trans-SCH-A and cis-SCH-A via a stereodivergent cyclopropanation protocol.
A highly diastereoselective cyclopropanation protocol has been employed in the syntheses of trans-SCH-A and cis-SCH-A. This strategy encompasses a stereodivergent procedure for the preparation of syn- and anti-cyclopropane diastereoisomers in high dr from a common allylic carbamate precursor.
Csatayová
Kristína
K
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Davies
Stephen G
SG
Lee
James A
JA
Ling
Kenneth B
KB
Roberts
Paul M
PM
Russell
Angela J
AJ
Thomson
James E
JE
D003521:Cyclopropanes / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
D003521:Cyclopropanes; D009570:Nitriles; D010879:Piperazines; D017481:Receptors, Somatostatin; C511125:SCH-A compound; D014508:Urea; C030797:cyclopropane