Killing the killer: natural killer cells to treat Ewing's sarcoma.
Cho and coworkers show that Ewing's sarcoma cells are highly sensitive to expanded allogeneic natural killer (NK) cells, partially through a NKG2D- and DNAM-1-dependent mechanism. Using an orthotopic murine model, they also show that irradiation significantly enhances the NK-cell killing of these tumors.
Ahn
Yong-Oon
YO
Hematology, Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Weigel
Brenda
B
Verneris
Michael R
MR
D000818:Animals; D001859:Bone Neoplasms / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D012512:Sarcoma, Ewing / Q000628:therapy*