Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate.
The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (k(r) > 10(9) M(-1)s(-1)) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy.
Fasani
Elisa
E
Dip. Chimica Organica, Università di Pavia, viale Taramelli 10, 27100, Italy.
Manet
Ilse
I
Capobianco
Massimo L
ML
Monti
Sandra
S
Pretali
Luca
L
Albini
Angelo
A
D024841:Fluoroquinolones / Q000138:chemical synthesis*; D006157:Guanosine Monophosphate / Q000737:chemistry*; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis*
D024841:Fluoroquinolones; D017319:Photosensitizing Agents; D006157:Guanosine Monophosphate