Diagnosis of co-morbid axis-I psychiatric disorders among women with newly diagnosed, untreated endocrine disorders.
OBJECTIVE
To determine the prevalence of major depressive disorder (MDD) and other selected axis-I disorders among women with newly diagnosed, untreated endocrine disorders.


METHODS
Two hundred and eighteen consecutive women, aged 18-65, with newly diagnosed, untreated endocrine disorders were referred for potential diagnosis of co-morbid axis-I disorders with the use of the Structured Clinical Interview for Axis I-Patient Edition (SCID-P). The SCID-P was re-administered after 12 weeks.


RESULTS
At baseline, 64 (29.3%) women met criteria for at least one axis-I disorder. Women who were diagnosed with hyperthyroidism were more likely to meet criteria for generalized anxiety disorder and panic disorder than women without hyperthyroidism. Nine of 154 (5.8 %) women who did not meet criteria for an axis-I disorder at baseline met criteria for at least one axis-I disorder during follow-up. Among them, the presence of diabetes mellitus was statistically correlated with a higher probability of developing major depressive disorder at follow-up.


CONCLUSIONS
Although preliminary, our findings are consistent with previous studies and suggest an increased prevalence of MDD and other axis-I disorders among women with newly diagnosed endocrine disorders, providing further evidence suggesting that women with endocrine abnormalities may be at increased risk of depression and/or anxiety disorders.
Fornaro
Michele
M
Department of Neuroscience, Section of Psychiatry, University of Genova, Genoa, Italy. Dott.Fornaro@gmail.com
Iovieno
Nadia
N
Clementi
Nicoletta
N
Boscaro
Marco
M
Paggi
Francesca
F
Balercia
Giancarlo
G
Fava
Maurizio
M
Papakostas
George I
GI
D000224:Addison Disease / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D000328:Adult; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D004700:Endocrine System Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D006980:Hyperthyroidism / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D007037:Hypothyroidism / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D007558:Italy; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D012307:Risk Factors