title: Gastrointestinal cancer educational case series: the history and management of complex cases in gi oncology. A 72 year-old man with metastatic gastric cancer.
abstract: BACKGROUND
  Gastric cancer is the third most common cancer worldwide and the second leading cause of cancer deaths. Appropriate staging and treatment options relate to the stage of disease and performance status of the patient.
  
  
  METHODS
  Here we present the case of a 72 year old male, with an initial presentation of apparently locally advanced gastric cancer. On discovery of metastatic disease, the utility of palliative gastrectomy, and first and second line chemotherapy are discussed.
  
  
  CONCLUSIONS
  This case demonstrates the potential value of sequential lines of chemotherapy in good performance status patients with advanced gastric cancer. Further research will be necessary in order to assess the utility of newer targeted agents in this setting.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, NY, USA, smythe@mskcc.org.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Smyth
authors.forename: Ghassan K
authors.initials: GK
authors.lastname: Abou-Alfa
authors.forename: Maeve
authors.initials: M
authors.lastname: Lowery
authors.forename: Ali
authors.initials: A
authors.lastname: Shamseddine
authors.forename: Ashwaq
authors.initials: A
authors.lastname: Al-Olayan
authors.forename: Mohamed
authors.initials: M
authors.lastname: Naghy
authors.forename: Derek
authors.initials: D
authors.lastname: Power
authors.forename: Teddy
authors.initials: T
authors.lastname: Saliba
authors.forename: David
authors.initials: D
authors.lastname: Kelsen
authors.forename: Manish A
authors.initials: MA
authors.lastname: Shah
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D018253:Adenoma, Villous / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005472:Fluorouracil / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin