Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.
Alcaro
Stefano
S
Dipartimento di Scienze Farmacobiologiche, Università degli Studi "Magna Graecia" di Catanzaro, Italy. alcaro@unicz.it
Artese
Anna
A
Botta
Maurizio
M
Zizzari
Alessandra T
AT
Orallo
Francisco
F
Ortuso
Francesco
F
Schenone
Silvia
S
Brullo
Chiara
C
Yáñez
Matilde
M
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001665:Binding Sites; D045744:Cell Line, Tumor; D003198:Computer Simulation; D051545:Cyclooxygenase 1 / Q000737:chemistry / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; C118531:pyrazolopyridine; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2