title: Intron 12 in NTRK3 is associated with bipolar disorder.
abstract: Based on the important role of neurotrophic factors in brain development and plasticity and reports of association between schizophrenia and the gene neurotrophic tyrosine kinase receptor 3 (NTRK3), we investigated associations of bipolar disorder with polymorphisms in NTRK3. Recently, our group reported evidence for a possible association of NTRK3 polymorphisms with hippocampal function and schizophrenia. In the present study, we used a homogenous Norwegian case-control sample (the TOP study) consisting of 194 patients diagnosed with bipolar disorder and 336 healthy controls genotyped on the Affymetrix Genome-wide Human SNP Array 6.0. In total 149 markers were investigated for SNP-disease association. Polymorphisms in over 20 markers were nominally associated with bipolar disorder, covering intron 5 to intron 12. Interestingly, our markers appeared to be located close or within the linkage regions reported in schizophrenia, early-onset major depressive disorder and eating disorder, supporting the hypothesis that some genes influence risk beyond traditional diagnostic boundaries.
authors.affiliation: Department of Psychiatry, Oslo University Hospital-Ullevål, Oslo, Norway. lavinia.athanasiu@medisin.uio.no
authors.forename: Lavinia
authors.initials: L
authors.lastname: Athanasiu
authors.forename: Morten
authors.initials: M
authors.lastname: Mattingsdal
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Elin
authors.initials: E
authors.lastname: Inderhaug
authors.forename: Trude
authors.initials: T
authors.lastname: Lien
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
authors.forename: Steinar
authors.initials: S
authors.lastname: Lorentzen
authors.forename: Gunnar
authors.initials: G
authors.lastname: Morken
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009664:Norway; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020812:Receptor, trkC / Q000235:genetics*; D055815:Young Adult
chemical_list: D020812:Receptor, trkC