[The role of prostaglandins in platelet aggregation in metabolic syndrome].
The role of metabolic products of arachidonic acid and thromboxans in metabolic syndrome was evaluated in 42 patients and 16 healthy subjects. The levels of arachidonic acid and thromboxane were shown to be elevated in patients with metabolic syndrome which accounted for enhanced platelet aggregation in response to ADP, adrenaline, and collagen. It is concluded that that decreased level of cyclic nucleotides (cAMP) and prostacyclin in combination with a rise in the content of Willebrand factor in patients with metabolic syndrome is a major contributor to the development of platelet activity.
Sokolov
E I
EI
Lavrenova
N Iu
NIu
Goloborodova
I V
IV
D000244:Adenosine Diphosphate / Q000494:pharmacology; D016718:Arachidonic Acid / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D003094:Collagen / Q000494:pharmacology; D000242:Cyclic AMP / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D011464:Epoprostenol / Q000097:blood; D006487:Hemostasis; D006801:Humans; D066298:In Vitro Techniques; D024821:Metabolic Syndrome / Q000097:blood*; D010974:Platelet Aggregation; D011449:Prostaglandin Endoperoxides / Q000097:blood; D011453:Prostaglandins / Q000097:blood*; D013931:Thromboxanes / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
D011449:Prostaglandin Endoperoxides; D011453:Prostaglandins; D013931:Thromboxanes; D014841:von Willebrand Factor; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen; D011464:Epoprostenol; D000242:Cyclic AMP; D004837:Epinephrine