In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens.
We compared the in vitro activities of isavuconazole, posaconazole, voriconazole, and fluconazole against Dipodascus capitatus (n = 21), Saccharomyces cerevisiae (n = 20), Rhodotorula mucilaginosa (n = 18), and Trichosporon spp. (n = 15). The MIC(50)s, MIC(90)s, and MIC ranges (in microg/ml) obtained using the CLSI M27-A3 procedure were as follows: isavuconazole, 0.125, 0.5, and < or = 0.015 to 2; posaconazole, 0.5, 2, and < or = 0.015 to > 16; voriconazole, 0.125, 2, and < or = 0.015 to 8; and fluconazole, 4, > 128, and < or = 0.125 to > 128. Isavuconazole showed potent activity against the isolates studied.
Guinea
Jesús
J
Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain. jguineaortega@yahoo.es
Recio
Sandra
S
Escribano
Pilar
P
Peláez
Teresa
T
Gama
Beatriz
B
Bouza
Emilio
E
D000935:Antifungal Agents / Q000494:pharmacology*; D055157:Dipodascus / Q000187:drug effects; D015725:Fluconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D012248:Rhodotorula / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology*; D014250:Trichosporon / Q000187:drug effects; D065819:Voriconazole
D000935:Antifungal Agents; D009570:Nitriles; D011725:Pyridines; D011743:Pyrimidines; D014230:Triazoles; C508735:isavuconazole; C101425:posaconazole; D015725:Fluconazole; D065819:Voriconazole