Cardiovascular genetic medicine: the genetics of coronary heart disease.
Advances in genomic technologies have provided researchers with an unprecedented opportunity to identify genes that may contribute to the development of coronary heart disease. The power of these technologies lies in their ability to survey the entire genome in a nonbiased fashion to find genes and gene variants associated with coronary heart disease. This article reviews different genomic approaches for studying coronary heart disease and the clinical implications of using genetic information.
Seo
David
D
Medicine, University of Miami School of Medicine, 1120 NW 14th Street, Room 1116, Miami, FL 33136, USA. dseo@med.miami.edu
Goldschmidt-Clermont
Pascal J
PJ
D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D020869:Gene Expression Profiling; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods; D006801:Humans; D009154:Mutation; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011379:Prognosis