Quiescence: a mechanism for escaping the effects of drug on cell populations.
We point out that a simple and generic strategy in order to lower the risk for extinction consists in developing a dormant stage in which the organism is unable to multiply but may die. The dormant organism is protected against the poisonous environment. The result is to increase the survival probability of the entire population by introducing a type of zero reproductive fitness. This is possible, because the reservoir of dormant individuals act as a buffer that can cushion fatal fluctuations in the number of births and deaths, which without the dormant population would have driven the entire population to extinction.
Alarcón
Tomás
T
Basque Centre for Applied Mathematics, Bizkaia Technology Park, Derio, Spain. alarcon@bcamath.org
Jensen
Henrik Jeldtoft
HJ
D005075:Biological Evolution; D003198:Computer Simulation; D004351:Drug Resistance; D053476:Extinction, Biological; D008954:Models, Biological