In vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum.
This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.
Brilhante
Raimunda Sâmia Nogueira
RS
Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil. brilhante@ufc.br
Fechine
Maria Auxiliadora Bezerra
MA
Cordeiro
Rossana de Aguiar
Rde A
Rocha
Marcos Fábio Gadelha
MF
Ribeiro
Joyce Fonteles
JF
Monteiro
André Jalles
AJ
de Lima
Rita Amanda Chaves
RA
Mesquita
Jacó Ricarte Lima
JR
de Camargo
Zoilo Pires
ZP
Sidrim
José Júlio Costa
JJ
D000890:Anti-Infective Agents / Q000494:pharmacology*; D006658:Histoplasma / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D000890:Anti-Infective Agents; D014295:Trimethoprim; D013420:Sulfamethoxazole