Polyendocrinopathy in children, adolescents, and young adults with type 1 diabetes: a multicenter analysis of 28,671 patients from the German/Austrian DPV-Wiss database.
OBJECTIVE
To investigate diabetes-specific autoantibodies and additional autoimmune phenomena in a large cohort of young patients with type 1 diabetes.


METHODS
Data from 28,671 patients <30 years with type 1 diabetes from 242 specialized centers in Germany and Austria were analyzed.


RESULTS
At least one beta-cell antibody was present in 81.6% of patients. beta-cell-Ab-negative patients were significantly younger at diabetes onset (P < 0.0001). A total of 19.6% had positive thyroid antibodies with female predominance (62%, P < 0.0001). Antibodies to tissue transglutaminase were present in 10.7%, with a significantly longer duration of diabetes (P < 0.0001). Parietal cell antibodies were found in 283 patients, associated with older age (P < 0.001), and adrenal antibodies were present in 94 patients. In 575 patients, at least three different autoimmune phenomena were present.


CONCLUSIONS
Thyroid autoimmunity and antibodies suggestive for celiac disease are the most prevalent additional immune phenomena in type 1 diabetes. Parietal/adrenal antibodies are rare.
Warncke
Katharina
K
Department of Pediatrics, Technische Universität München, Munich, Germany. katharina.warncke@lrz.tu-muenchen.de
Fröhlich-Reiterer
Elke E
EE
Thon
Angelika
A
Hofer
Sabine E
SE
Wiemann
Dagobert
D
Holl
Reinhard W
RW
D000293:Adolescent; D000328:Adult; D001317:Austria; D015551:Autoimmunity / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology*; D005260:Female; D005858:Germany; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D050417:Insulin-Secreting Cells / Q000276:immunology; D008297:Male; D016884:Polyendocrinopathies, Autoimmune / Q000209:etiology* / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology; D055815:Young Adult