Prevalence and determinants of hyperglycemia in very low birth weight infants: cohort analyses of the NIRTURE study.
OBJECTIVE
To investigate the prevalence and determinants of hyperglycemia in the preterm population, as part of the Neonatal Insulin Therapy in Europe (NIRTURE) Trial.


METHODS
We conducted prospective cohort analyses of continuous glucose monitoring data from control infants participating in an international randomized controlled trial. Data were collected from 188 very low birth weight infants (<1500 g).


RESULTS
In the first week of life, 80% of infants had evidence of glucose levels >8 mmol/L, and 32% had glucose levels >10 mmol/L >10% of the time. Independent risk factors for hyperglycemia included increasing prematurity, small size at birth, use of inotropes, lipid infusions, and sepsis. There was a lack of association between rate of dextrose infused and risk of hyperglycemia.


CONCLUSIONS
The prevalence of hyperglycemia in the very low birth weight infant is high, with marked variability in prevalence between infants, not simply related to rates of glucose infused, but to other potentially modifiable risk factors.
Beardsall
Kathryn
K
Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital NHS Trust, Cambridge, UK. kb274@cam.ac.uk
Vanhaesebrouck
Sophie
S
Ogilvy-Stuart
Amanda L
AL
Vanhole
Christine
C
Palmer
Chris R
CR
Ong
Ken
K
vanWeissenbruch
Mirjam
M
Midgley
Paula
P
Thompson
Mike
M
Thio
Marta
M
Cornette
Luc
L
Ossuetta
Iviano
I
Iglesias
Isabel
I
Theyskens
Claire
C
de Jong
Miranda
M
Gill
Bryan
B
Ahluwalia
Jag S
JS
de Zegher
Francis
F
Dunger
David B
DB
D015331:Cohort Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D019102:Infant, Very Low Birth Weight; D008297:Male; D015337:Multicenter Studies as Topic; D015995:Prevalence; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic