title: Rational manipulation of amyloidogenesis using an atomic level map of peptide-fibril interactions.
abstract: Amyloidogenic aggregation has been the subject of intense research over the past few decades, but the mechanisms underlying the early stages of amyloidogenesis remain elusive. Here we demonstrate for the first time manipulation of amyloidogenesis based on an atomic level map of peptide-fibril interactions in early- and late-stage ordered aggregation. Several point mutants with specific amyloidogenic properties are introduced, including one that "stalls" early in the aggregation process, forming early-stage fibrillar aggregates, but not mature fibrils.
authors.affiliation: Department of Chemistry, York University, Toronto, Ontario M3J 1P6, Canada.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Liang
authors.forename: Shohreh Zahedi
authors.initials: SZ
authors.lastname: Jasbi
authors.forename: Sylvie
authors.initials: S
authors.lastname: Morin
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Wilson
mesh_terms: D004347:Drug Interactions; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D017354:Point Mutation
chemical_list: D010455:Peptides