title: Calcium phosphate biomaterials as bone drug delivery systems: a review.
abstract: A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems. In the first part, a brief update is given on the performance of both CaP ceramics and CaP cements. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems. Experimental works performed for local delivery are reported. In particular, a description is given of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs.
authors.affiliation: PRES UNAM, INSERM UMR, LIOAD, Nantes, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Verron
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Khairoun
authors.forename: Jerome
authors.initials: J
authors.lastname: Guicheux
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bouler
mesh_terms: D000818:Animals; D001842:Bone and Bones; D002130:Calcium Phosphates / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000009:adverse effects; D006801:Humans
chemical_list: D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D004337:Drug Carriers