The relationships between leptin and measures of fitness and fatness are dependent upon obesity status in youth.
The relationship between peak aerobic fitness (peakVO2) and plasma leptin was assessed in 25 normal (BMI < 85th %tile) and 25 overweight (BMI > 85th %tile) youth, ages 7-17 years. In the overall analysis peakVO2 was related to leptin when expressed in mL/kg/min (R2 = .516, p < .0001), or as ml/kg(FFM)/min (R2 = .127, p = .01). The relationships between peak VO2 and leptin were no longer significant when percent bodyfat was added to the models. In subanalyses by weight groups, peak VO2: leptin relationships were not evident for normal weight, but remained for overweight youth. In conclusion the relationship between aerobic fitness and leptin in youth is dependent upon weight status.
Hosick
Peter A
PA
Dept. of EXSS, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700, USA.
McMurray
Robert G
RG
Cooper
Dan M
DM
D000293:Adolescent; D050218:Body Fat Distribution; D015992:Body Mass Index; D002648:Child; D005080:Exercise Test; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D050177:Overweight / Q000097:blood* / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D012044:Regression Analysis
D020738:Leptin