title: The paracrine effect: pivotal mechanism in cell-based cardiac repair.
abstract: Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvironment. The paracrine factors secreted by these cells represent a pivotal mechanism underlying the benefits of cell-mediated cardiac repair. This article reviews key studies behind the paracrine effect related to the cardiac reparative effects of cardiac cell therapy.
authors.affiliation: Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, 5000 Belanger St. (East), Montréal, QC, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Maltais
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Tremblay
authors.forename: Louis P
authors.initials: LP
authors.lastname: Perrault
authors.forename: Hung Q
authors.initials: HQ
authors.lastname: Ly
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D019899:Paracrine Communication; D012038:Regeneration; D033581:Stem Cell Transplantation; D016896:Treatment Outcome
chemical_list: D036341:Intercellular Signaling Peptides and Proteins