title: Gene polymorphisms and their role in epilepsy treatment and prognosis.
abstract: The human genome carries an enormous number of genetic variants, many of them of functional consequence. In epilepsy, they are likely to be involved in drug-specific treatment efficacy, unwanted or even toxic drug reactions, teratogenic risks in pregnancy as well as in the long-term prognosis of patients with epilepsy. As in many other disorders with a complex genetic background, the associated genetic variants that could be verified successfully in replication studies are still only a few. However, new techniques and improved research strategies are likely to increase their number in the foreseeable future, although at a much slower pace as initially expected.
authors.affiliation: Institute of Human Genetics, University Hospital, Ludwig-Maximilians-University of Munich, Goethestr. 29, 80336, Munich, Germany. Ortrud.Steinlein@med.uni-muenchen.de
authors.forename: Ortrud K
authors.initials: OK
authors.lastname: Steinlein
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000235:genetics; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: D000927:Anticonvulsants