title: Childhood optic neuritis clinical features and outcome.
abstract: OBJECTIVE
  To describe clinical features and outcome of a series of children with first-episode optic neuritis investigated in three paediatric neurology centres.
  
  
  METHODS
  Databases were searched to identify children (<16 years) with optic neuritis and life table analysis was used.
  
  
  RESULTS
  44 children (female/male ratio 1.8) median age 10.9 years were followed up for median 1 year. Optic neuritis was unilateral in 43%. Maximal visual deficit was severe (<6/60) in 77%, with full recovery in 70%. Cumulative probability of developing MS (11/44) or NMO (3/44) at 2 years was 0.45. Relapsing optic neuritis was a strong predictor for development of MS or NMO. A positive MRI (>1 brain T2 hyperintense lesion) was a strong predictor for development of MS.
  
  
  CONCLUSIONS
  Childhood optic neuritis is associated with severe visual deficit with good recovery. An initial abnormal MRI brain scan or relapsing optic neuritis should alert the clinician to MS or NMO diagnosis.
authors.affiliation: Institute of Child Health, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH. michaelabsoud@childdemyelination.org.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Absoud
authors.forename: Carole
authors.initials: C
authors.lastname: Cummins
authors.forename: Nivedita
authors.initials: N
authors.lastname: Desai
authors.forename: Artemis
authors.initials: A
authors.lastname: Gika
authors.forename: Niamh
authors.initials: N
authors.lastname: McSweeney
authors.forename: Pinki
authors.initials: P
authors.lastname: Munot
authors.forename: Cheryl
authors.initials: C
authors.lastname: Hemingway
authors.forename: Ming
authors.initials: M
authors.lastname: Lim
authors.forename: Ken K
authors.initials: KK
authors.lastname: Nischal
authors.forename: Evangeline
authors.initials: E
authors.lastname: Wassmer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004812:Epidemiologic Methods; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology; D009471:Neuromyelitis Optica / Q000209:etiology; D009902:Optic Neuritis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D012008:Recurrence; D014786:Vision Disorders / Q000209:etiology
chemical_list: D005938:Glucocorticoids