title: New bufadienolides and C(23) steroids from the venom of Bufo bufo gargarizans.
abstract: Six new bufadienolides (1-6) and two new C(23) steroids (7 and 8), together with three known compounds (9-11) were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated by spectroscopic analysis and single-crystal X-ray diffraction. In vitro cytotoxicities of all compounds were evaluated in A549 cancer cell line. Compounds 2, 3 and 10 showed significant cytotoxic activities.
authors.affiliation: Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tian
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Liu
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000664:Amphibian Venoms / Q000737:chemistry*; D000818:Animals; D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002023:Bufo bufo; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000664:Amphibian Venoms; D002018:Bufanolides; C087925:bufadienolide