title: Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature.
abstract: This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung.On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation.
authors.affiliation: Department of Pathology, Vestfold County Hospital, Halfdan Wilhelmsens Alle' 17, N-3116 Tønsberg, Norway. tor.klingen@siv.no
authors.forename: Tor A
authors.initials: TA
authors.lastname: Klingen
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Marian D
authors.initials: MD
authors.lastname: Gundersen
authors.forename: Hans
authors.initials: H
authors.lastname: Aas
authors.forename: Bjørn
authors.initials: B
authors.lastname: Westre
authors.forename: Torill
authors.initials: T
authors.lastname: Sauer
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008408:Mastectomy; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000032:analysis*; D049268:Positron-Emission Tomography; D000074482:Thyroid Nuclear Factor 1; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors