title: The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates.
abstract: Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of mood and anxiety disorders following disrupted mother-infant attachment, we examined whether adverse rearing conditions lead to white matter impairment of the ALIC. We examined white matter integrity using Diffusion Tensor Imaging (DTI) on a 3T-MRI. Twenty-one adult male Bonnet macaques participated in this study: 12 were reared under adverse [variable foraging demand (VFD)] conditions whereas 9 were reared under normative conditions. We examined ALIC, posterior limb of the internal capsule (PLIC) and occipital white matter. VFD rearing was associated with significant reductions in FA in the ALIC with no changes evident in the PLIC or occipital cortex white matter. Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility.
authors.affiliation: SUNY Downstate Medical Center, Primate Behavior Laboratory, Brooklyn, NY, USA. Copstat00@aol.com
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Coplan
authors.forename: Chadi G
authors.initials: CG
authors.lastname: Abdallah
authors.forename: Cheuk Y
authors.initials: CY
authors.lastname: Tang
authors.forename: Sanjay J
authors.initials: SJ
authors.lastname: Mathew
authors.forename: Jose
authors.initials: J
authors.lastname: Martinez
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Hof
authors.forename: Eric L P
authors.initials: EL
authors.lastname: Smith
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dwork
authors.forename: Tarique D
authors.initials: TD
authors.lastname: Perera
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pantol
authors.forename: David
authors.initials: D
authors.lastname: Carpenter
authors.forename: Leonard A
authors.initials: LA
authors.lastname: Rosenblum
authors.forename: Dikoma C
authors.initials: DC
authors.lastname: Shungu
authors.forename: Joel
authors.initials: J
authors.lastname: Gelernter
authors.forename: Arie
authors.initials: A
authors.lastname: Kaffman
authors.forename: Andrea
authors.initials: A
authors.lastname: Jackowski
authors.forename: Joan
authors.initials: J
authors.lastname: Kaufman
authors.forename: Jack M
authors.initials: JM
authors.lastname: Gorman
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000473:pathology; D056324:Diffusion Tensor Imaging; D004195:Disease Models, Animal; D005247:Feeding Behavior; D005260:Female; D020772:Internal Capsule / Q000254:growth & development* / Q000473:pathology; D008255:Macaca radiata; D008297:Male; D008425:Maternal Behavior; D019964:Mood Disorders / Q000473:pathology; D009769:Object Attachment; D009778:Occipital Lobe / Q000254:growth & development / Q000473:pathology; D013315:Stress, Psychological / Q000473:pathology / Q000523:psychology*