Serum interleukin-8 and insulin like growth factor-1 in Egyptian bladder cancer patients.
BACKGROUND
Bladder cancer is a major health problem in Egypt as it represents the most common malignancy.


OBJECTIVE
Evaluation of the potential usefulness of serum IL-8 and IGF-1 in Egyptian bladder cancer patients.


METHODS
Serum levels of IL-8 and IGF-1 were determined in 51 bladder cancer patients and 45 controls using a chemiluminescence enzyme immunometric assay.


RESULTS
Serum IL-8 was significantly higher in cancer patients than in controls (P < 0.0001). It was significantly higher in patients with invasive cancer than those with superficial cancer (P < 0.01). Also, IL-8 showed a significant elevation in relation to schistosomal infection (P = 0.02) however, it did not differ in relation to either pathological type of tumor or its grade (P > 0.05). Receiver operating characteristic (ROC) curve indicated that IL-8 cut-off value of 35 pg/mL yielded the best combination of sensitivity (71%) and specificity (98%) for differentiating patients with bladder cancer from control subjects. Serum IGF-1 levels showed no significant difference between bladder cancer patients and controls (P > 0.05). There was no relationship between IGF-1 levels and clinicopathological parameters.


CONCLUSIONS
In Egyptian patients with bladder cancer, serum IL-8 is significantly elevated and its level is related to tumor invasion and associated schistosomal infection. Moreover, serum IGF-1 level does not help as a serum tumor marker in these patients.
Mahmoud
Moushira A
MA
Department of Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. moushiraa@yahoo.com
Ali
Mohamed H
MH
Hassoba
Howayda M
HM
Elhadidy
Gehan S
GS
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D004534:Egypt; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012552:Schistosomiasis / Q000150:complications; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology*
D014408:Biomarkers, Tumor; D016209:Interleukin-8; D007334:Insulin-Like Growth Factor I