Imaging and modeling of myocardial metabolism.
Current imaging methods have focused on evaluation of myocardial anatomy and function. However, since myocardial metabolism and function are interrelated, metabolic myocardial imaging techniques, such as positron emission tomography, single photon emission tomography, and magnetic resonance spectroscopy present novel opportunities for probing myocardial pathology and developing new therapeutic approaches. Potential clinical applications of metabolic imaging include hypertensive and ischemic heart disease, heart failure, cardiac transplantation, as well as cardiomyopathies. Furthermore, response to therapeutic intervention can be monitored using metabolic imaging. Analysis of metabolic data in the past has been limited, focusing primarily on isolated metabolites. Models of myocardial metabolism, however, such as the oxygen transport and cellular energetics model and constraint-based metabolic network modeling, offer opportunities for evaluation interactions between greater numbers of metabolites in the heart. In this review, the roles of metabolic myocardial imaging and analysis of metabolic data using modeling methods for expanding our understanding of cardiac pathology are discussed.
Obrzut
Sebastian
S
Department of Radiology, University of California San Diego, San Diego, CA, USA. sobrzut@ucsd.edu
Jamshidi
Neema
N
Karimi
Afshin
A
Birgersdotter-Green
Ulrika
U
Hoh
Carl
C
D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000378:metabolism; D016027:Heart Transplantation / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008432:Mathematical Computing; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals