title: Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
abstract: A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-<75 nmol/L, no statistically significant associations were observed for <37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87, 1.70), 37.5-<50 (OR = 1.03, 95% CI: 0.75, 1.41), or > or =75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index of > or =25 kg/m(2) (P(interaction) < 0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women.
authors.affiliation: Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA. wei.zheng@vanderbilt.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Kim N
authors.initials: KN
authors.lastname: Danforth
authors.forename: Shelley S
authors.initials: SS
authors.lastname: Tworoger
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.forename: Alpa V
authors.initials: AV
authors.lastname: Patel
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Mark P
authors.initials: MP
authors.lastname: Purdue
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Kirk
authors.initials: K
authors.lastname: Snyder
authors.forename: Emily
authors.initials: E
authors.lastname: Steplowski
authors.forename: Kala
authors.initials: K
authors.lastname: Visvanathan
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Chinonye
authors.initials: C
authors.lastname: Harvey
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Horst
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D050177:Overweight / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D014807:Vitamin D