title: Diagnostic validity of high-density barium sulfate in gastric cancer screening: follow-up of screenees by record linkage with the Osaka Cancer Registry.
abstract: BACKGROUND
  The use of high-density barium sulfate was recommended by the Japan Society of Gastroenterological Cancer Screening (JSGCS) in 2004. We evaluated the diagnostic validity of gastric cancer screening that used high-density barium sulfate.
  
  
  METHODS
  The study subjects were 171 833 residents of Osaka, Japan who underwent gastric cancer screening tests at the Osaka Cancer Prevention and Detection Center during the period from 1 January 2000 through 31 December 2001. Screening was conducted using either high-density barium sulfate (n = 48 336) or moderate-density barium sulfate (n = 123 497). The subjects were followed up and their medical records were linked to those of the Osaka Cancer Registry through 31 December 2002. The results of follow-up during 1 year were defined as the gold standard, and test performance values were calculated.
  
  
  RESULTS
  The sensitivity and specificity of the screening test using moderate-density barium sulfate were 92.3% and 91.0%, respectively, while the sensitivity and specificity of the high-density barium test were 91.8% and 91.4%, respectively. The results of area under receiver-operating-characteristic (ROC) curve analysis revealed no significant difference between the 2 screening tests.
  
  
  CONCLUSIONS
  Screening tests using high- and moderate-density barium sulfate had similar validity, as determined by sensitivity, specificity, and ROC curve analysis.
authors.affiliation: Department of Radiological Technology, Graduate School of Health Sciences, Okayama University, Osaka 536-8588, Japan. kenyu1203@nike.eonet.ne.jp
authors.forename: Kenyu
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Hideo
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Chikazumi
authors.initials: C
authors.lastname: Kuroda
authors.forename: Tsugio
authors.initials: T
authors.lastname: Kubo
authors.forename: Akira
authors.initials: A
authors.lastname: Oshima
authors.forename: Toshizo
authors.initials: T
authors.lastname: Katsuda
authors.forename: Tadao
authors.initials: T
authors.lastname: Kuwano
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001466:Barium Sulfate / Q000737:chemistry; D003287:Contrast Media; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008498:Medical Record Linkage; D008875:Middle Aged; D012372:ROC Curve; D011859:Radiography; D012042:Registries; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate