title: Effects of autonomic interventions on atrial restitution properties.
abstract: Atrial Restitution Properties.
  
  
  BACKGROUND
  The restitution hypothesis suggests that action potential duration (APD) restitution slope >1 predicts the development of alternans and fibrillation. This study aimed to investigate the effects of autonomic interventions on the restitution properties on the atria.
  
  
  RESULTS
  In 10 anesthetized open-chest dogs, multiple electrode catheters were sutured at pulmonary vein and atrial sites. The monophasic APD was recorded by an Ag-AgCl catheter. The restitution curve at each site was constructed by plotting each APD(90) against the preceding diastolic interval at incremental atrial pacing rates before and after vagal nerve stimulation (VNS) or ganglionated plexi (GP) ablation. Before GP ablation, VNS significantly shortened the APD, flattened the restitution curves and suppressed the APD alternans at each site, while increasing the atrial fibrillation (AF) inducibility and duration (P < 0.05 for all). These effects were eliminated by GP ablation. Compared with the baseline, GP ablation significantly increased the APD, steepened the restitution curves, and facilitated the APD alternans at each site while decreasing the AF inducibility and duration (P < 0.05 for all). VNS significantly increased (0.5 ± 0.2 vs 0.3 ± 0.1, P < 0.05) and GP ablation decreased (0.2 ± 0.1 vs 0.3 ± 0.1, P < 0.05) the spatial dispersion of the slopes of APDR curves, respectively.
  
  
  CONCLUSIONS
  The maximal slope of APDR curve alone does not fully account for the changes of AF inducibility and duration induced by autonomic interventions; instead, the spatial dispersion of the APDR kinetics may be an important determinant for susceptibility of AF.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China Oklahoma Medical Research Foundation, Oklahoma University, Oklahoma, USA.
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.forename: Bo
authors.initials: B
authors.lastname: He
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Congxin
authors.initials: C
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D004285:Dogs; D006325:Heart Atria / Q000503:physiopathology*; D006329:Heart Conduction System / Q000503:physiopathology*; D011667:Pulmonary Veins / Q000503:physiopathology*; D055536:Vagus Nerve Stimulation