title: Ophiocerol, a novel macrocylic neolignan from the aquatic fungus Ophioceras dolichostomum YMF1.00988.
abstract: From cultural filtrates of the freshwater fungus Ophioceras dolichostomum YMF1.00988 a novel neolignan with an unprecedented dibenzo-1,6-dioxacyclodecane carbon skeleton, ophiocerol (1), was isolated, and the known compounds isoamericanoic acid A (2) and caffeic acid (3) were identified. The structure of the novel compound was determined by interpretation of its spectroscopic data, including 1D and 2D, (1)H and (13)C NMR (COSY, HMQC, HMBC, NOESY), and MS. Compounds 1-3 were assayed for their nematicidal activity against Bursaphelenchus xylophilus as well as their antifungal activity against several plant pathogen fungi.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming, P.R. China.
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Dong
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.forename: Hong-Chuang
authors.initials: HC
authors.lastname: Song
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Wang
authors.forename: Kai-Ze
authors.initials: KZ
authors.lastname: Shen
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000969:Antinematodal Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017187:Tylenchida / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D000969:Antinematodal Agents; D017705:Lignans