title: Indexed left atrial volume is a more sensitive indicator of filling pressures and left heart function than is anteroposterior left atrial diameter.
abstract: BACKGROUND
  Left atrial (LA) size is an indicator of the pressure to which it is chronically subjected. Although guidelines recommend measuring it using volume indexed to body surface, the anteroposterior diameter is still normally used.
  
  
  OBJECTIVE
  To evaluate which of these measurements correlates better with atrial pressure-related echocardiographic parameters.
  
  
  METHODS
  Atrial diameter and volume, together with parameters of systolic function, diastolic function, pressure, and degree of mitral regurgitation, were measured in 121 consecutive outpatients.
  
  
  RESULTS
  Atrial diameter correlated with its indexed volume (r: 0.69) with a low degree of agreement for detecting dilation (Kappa: 0.51). Atrial diameter was related to the parameters associated with atrial pressure: E/E' (r: 0.44), pulmonary vein systolic/diastolic rates quotient (r: 0.25) and degree of mitral regurgitation (r: 0.19). The correlations improved when volume indexed to body surface was measured (r: 0.52; 0.38 and 0.44, respectively). In a multiple regression analysis that included E/E', pulmonary vein flow and degree of mitral regurgitation, LA diameter depended entirely on E/E' (r: 0.44; B: 0.04; P: 0.000). The relationship improved when the diameter was corrected for body surface or the volume was measured (r: 0.54 and 0.54, respectively), and in particular when volume indexed to body surface was measured (r: 0.66). In this case, pulmonary vein flow (B: 6.8; P: 0.03), degree of mitral regurgitation (B: 5.2; P: 0.000) and E/E' ratio (B: 0.8; P : 0.000) were included in the equation.
  
  
  CONCLUSIONS
  Indexed atrial volume correlates better with LA pressure surrogates than the anteroposterior diameter, even when this is corrected for body surface.
authors.affiliation: Unidad de Diagnóstico por Imagen Cardíaca [Cardiac Diagnostic Imaging Unit], Instituto de Cardiología [Institute of Cardiology], Hospital Ramón y Cajal, Madrid, Spain. jmoya.hrc@salud.madrid.org
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Moya-Mur
authors.forename: Ana
authors.initials: A
authors.lastname: García-Martín
authors.forename: Alberto
authors.initials: A
authors.lastname: García-Lledó
authors.forename: Soledad
authors.initials: S
authors.lastname: Ruiz-Leria
authors.forename: José J
authors.initials: JJ
authors.lastname: Jiménez-Nacher
authors.forename: Alicia
authors.initials: A
authors.lastname: Megias-Sanz
authors.forename: Dolores
authors.initials: D
authors.lastname: Taboada
authors.forename: Alfonso
authors.initials: A
authors.lastname: Muriel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult