title: A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene ( HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study.
abstract: The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available. Genotype frequencies and allele distributions for 23 011 participants were: TT 95.65 %, TG 4.29 % and GG 0.06 %; T 97.8 % and G 2.2 %. In regression analyses, the TG+GG group showed a significant positive relationship between TAG and SFA intake (+0.11 (95 % CI 0.02, 0.20) mmol TAG/l; P = 0.017; per 3 % SFA energy increase) while the TT individuals showed no change in the TAG levels related to SFA intake ( - 0.0007 (95 % CI - 0.02, 0.02) mmol TAG/l; P = 0.99). TG+GG individuals showed an inverse relationship between TAG and fibre intake higher ( - 0.14 (95 % CI - 0.22, - 0.05) mmol TAG/l than the TT group ( - 0.04 (95 % CI - 0.06, - 0.02) mmol TAG/l). In both cases the respective coefficient regressions of TAG were different between the genotype groups (Z = 2.27, P = 0.023 for SFA intake; Z = 2.19, P = 0.029 for fibre intake). Individuals carrying the G allele may show a greater response in lower TAG levels with reduced SFA intake and increased fibre intake compared with those homozygous for the T allele. The effectiveness of different dietary interventions to control serum lipids may vary according to HMGCR genotype.
authors.affiliation: DENCS, School of Nutrition and NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil. rfreitasmail@gmail.com
authors.forename: Renata N
authors.initials: RN
authors.lastname: Freitas
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Kelvin
authors.initials: K
authors.lastname: Wu
authors.forename: Richard
authors.initials: R
authors.lastname: Bowman
authors.forename: Hannah
authors.initials: H
authors.lastname: Jeffery
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Bingham
mesh_terms: D000368:Aged; D000483:Alleles; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000494:pharmacology*; D005060:Europe; D005227:Fatty Acids / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases