Synthesis of primary aryl amines through a copper-assisted aromatic substitution reaction with sodium azide.
A method is presented by which aryl halides and azides are converted to the corresponding primary aryl amines with copper(I) and sodium azide.
Markiewicz
John T
JT
Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, USA.
Wiest
Olaf
O
Helquist
Paul
P
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D019810:Sodium Azide / Q000737:chemistry*
D000588:Amines; D006846:Hydrocarbons, Halogenated; D003300:Copper; D019810:Sodium Azide