Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure.
A novel bridged nucleic acid bearing cyclic urea structure was successfully synthesized and introduced into oligonucleotide, displaying attractive characteristics of highly RNA selective hybridization ability and excellent resistance towards nuclease degradation.
Nishida
Masaru
M
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Baba
Takeshi
T
Kodama
Tetsuya
T
Yahara
Aiko
A
Imanishi
Takeshi
T
Obika
Satoshi
S
D000818:Animals; D017839:Crotalus / Q000378:metabolism*; D003500:Cyclization; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D012313:RNA / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
D009696:Nucleic Acids; D009841:Oligonucleotides; D012313:RNA; D014508:Urea; D010727:Phosphoric Diester Hydrolases