[Diagnostic and pathogenetic implications of the site specificity of antibody proteases in multiple sclerosis].
Disseminated sclerosis is currently regarded as a CNS autoimmune disease. One of the mechanisms behind this pathology is antibody (AB) formation. In this context, recent data on AB with proteolytic activity are of importance because they participate in selective proteolysis of myelin proteins in patients with disseminated sclerosis. This paper focuses on AB-proteases associated with disseminated sclerosis and site-specificity of antibody-mediated proteolysis of myelin basic protein. Protocol of serodiagnostic algorithm to be used in clinical practice is described.
Salafet
O V
OV
Ruzina
N D
ND
Ponomarenko
N A
NA
Friboulet
A
A
Kimova
M V
MV
Shmidt
T E
TE
Gabibov
A G
AG
Morse
H K
HK
Pal'tsev
M A
MA
Suchkov
S V
SV
D000595:Amino Acid Sequence; D000918:Antibody Specificity; D000938:Antigen-Presenting Cells / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D000939:Epitopes; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D012698:Serologic Tests; D013379:Substrate Specificity
D001323:Autoantibodies; D000939:Epitopes; D004676:Myelin Basic Protein; D010447:Peptide Hydrolases