title: IgG4-related lung disease in a worker occupationally exposed to asbestos.
abstract: A case of IgG4-related lung disease in a worker who had been exposed to asbestos is described. The patient had nocturnal cough and wheeze that responded to inhaled corticosteroid, and the radioallergosorbent test was positive against common allergens, suggesting an association with atopic asthma. IgE elevation is reported in asbestos-exposed workers, and asbestos exposure may cause atopic conditions. Predominance of Th2 cytokines and up-regulation of regulatory T lymphocytes have been reported in IgG4-related disease. IgG4-related disease may occur from hypersensitivity of the regulatory immune system to atopic conditions. Asbestos exposure may be a causal factor of IgG4-related disease.
authors.affiliation: Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Hamamatsu, Japan. ckm92650@star.odn.ne.jp
authors.forename: Mikio
authors.initials: M
authors.lastname: Toyoshima
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
authors.forename: Masato
authors.initials: M
authors.lastname: Kono
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kaida
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sugimura
mesh_terms: D001194:Asbestos / Q000009:adverse effects* / Q000276:immunology; D001249:Asthma / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000175:diagnosis / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D001194:Asbestos