Effect of ascorbic acid on the monosodium glutamate-induced neurobehavioral changes in periadolescent rats.
OBJECTIVE
In the current study we evaluated adverse effects of monosodium glutamate (MSG) on memory formation and its retrieval as well as the role of ascorbic acid (Vitamin-C) in prevention of MSG-induced alteration of neurobehavioral performance in periadolescent rats.


METHODS
Healthy male albino Wistar rats (4-6 weeks old), were randomly allotted in four groups. Group I: normal control, who remained in their homecage throughout the experimental period. Group II: vehicle control, who were orally administered with normal saline for three weeks. Group III: MSG, who were orally administered with aqueous solution of MSG (2 mg/g b.w/day), for three weeks. Group IV: MSG+AA, who were administered with aqueous solution of MSG, and subsequently by ascorbic acid (100 mg/kg b.w/day) orally for three weeks. After the experimental period, all animals from all groups were first tested for anxiety followed by passive avoidance behavior.


RESULTS
MSG significantly altered the neurobehavioral performance in rats. The alteration manifested as less time spent on the open arm during the EPM test and shorter entrance latency to the dark compartment during the passive avoidance task. All behavioral changes were significantly prevented by simultaneous administration of ascorbic acid with MSG.


CONCLUSIONS
The present data point to the neuroprotective role of ascorbic acid. The ascorbic acid can be used as a therapeutic agent in various cognitive deficits (Fig. 5, Ref. 25). Full Text (Free, PDF) www.bmj.sk.
Narayanan
Sareesh Naduvil
SN
Department of Physiology, Melaka Manipal Medical College, Manipal Campus, Manipal University, Manipal, Karnataka, India. sareeshnn@yahoo.co.in
Kumar
Raju Suresh
RS
Paval
Jaijesh
J
Nayak
Satheesha
S
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D005503:Food Additives / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D005503:Food Additives; D014815:Vitamins; D001205:Ascorbic Acid; D012970:Sodium Glutamate