Systemic inflammation caused by chronic periodontite in patients victims of acute ischemic heart attack.
OBJECTIVE
Infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (AIHD).


METHODS
One hundred one patients with AIHD with and without chronic periodontitis (CP) were included in this study. Patients were admitted to the HC UNICAMP and stratified into three groups: in group 1, we selected patients with severe chronic periodontitis (31 men and 19 women, mean age 55.1 +/- 11.29 years old); the group 2 with mild chronic periodontitis (40 men and 28 women, mean age 54.8 +/- 10.37 years old) and group 3 represented by the toothless (43 men and 20 women, mean age 67.5 +/- 8.55 years old). Blood samples were collected to measure the lipid profiles, hematological and blood glucose levels. In addition, biopsies of seventeen coronary arteries with atherosclerosis and an equal number of internal mammary arteries without atherosclerotic degeneration in group 1 were investigated. Statistical analysis by analysis of variance (ANOVA) and Scheffé test for multiple comparisons was performed.


RESULTS
Triglyceride and LDL levels were elevated in group 1 than in group 2. HDL were reduced by 20% in group 1 and remained reduced by 8% in toothless. Blood glucose was higher in group 1. DNA of periodontal bacteria was detected in 58.8% of the coronary arteries.


CONCLUSIONS
Patients with (AIHD) and severe chronic periodontitis may have altered lipid profile, as well as microorganisms associated with CP can permeate into coronary vessels.
Oliveira
Fernando José de
FJ
Pharmacology and Surgery Department at Faculty of Medical Sciences at UNICAMP, Campinas, SP, Brazil. fernandoimplantes@hotmail.com
Vieira
Reinaldo Wilson
RW
Coelho
Otávio Rizzi
OR
Petrucci
Orlando
O
Oliveira
Pedro Paulo Martins de
PP
Antunes
Nilson
N
Oliveira
Ivone Pires F de
IP
Antunes
Edson
E
D000208:Acute Disease; D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016993:Chlamydophila pneumoniae / Q000235:genetics / Q000302:isolation & purification; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications*; D003331:Coronary Vessels / Q000382:microbiology / Q000473:pathology; D004269:DNA, Bacterial / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008323:Mammary Arteries / Q000382:microbiology / Q000473:pathology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000382:microbiology* / Q000473:pathology
D001786:Blood Glucose; D004269:DNA, Bacterial; D008055:Lipids