title: A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.
abstract: A bis(thiosemicarbazonato)copper(ii) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.
authors.affiliation: School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia 3010.
authors.forename: Sinchun
authors.initials: S
authors.lastname: Lim
authors.forename: Brett M
authors.initials: BM
authors.lastname: Paterson
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Fodero-Tavoletti
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: O'Keefe
authors.forename: Roberto
authors.initials: R
authors.lastname: Cappai
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Barnham
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
authors.forename: Paul S
authors.initials: PS
authors.lastname: Donnelly
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D003301:Copper Radioisotopes / Q000737:chemistry; D006801:Humans; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry; D013882:Thiosemicarbazones / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013267:Stilbenes; D013882:Thiosemicarbazones