Sarcoid granulomas in the parathyroid gland - a case of dual pathology: hypercalcaemia due to a parathyroid adenoma and coexistent sarcoidosis with granulomas located within the parathyroid adenoma and thyroid gland.
We present a highly unusual and interesting case of coexistent hyperparathyroidism and sarcoidosis leading to hypercalcaemia. A 70 year old female presented with weight loss, constipation and dehydration. Investigations revealed marked hypercalcaemia with a non-suppressed PTH. In view of the degree of hypercalcaemia as well as the unintentional weight loss, investigations for malignancy were conducted -these were negative. Parathyroid imaging was then requested and an adenoma was identified. Surprisingly, surgery revealed the coexistence of a parathyroid adenoma with the unexpected finding of sarcoid granulomas within the parathyroid and thyroid glands. To our knowledge, this is the first such case reported. Further imaging confirmed pulmonary sarcoidosis and a serum ACE was elevated. Serum calcium levels did not respond to parathyroidectomy but eventually fell with steroid therapy.
Balasanthiran
Anjali
A
Department of Endocrinology, Respiratory, ENT, Pathology and Radiology, Lister Hospital, Stevenage, Hertfordshire, UK. ABala75@hotmail.com
Sandler
Belinda
B
Amonoo-Kuofi
Kwamena
K
Swamy
Rajiv
R
Kaniyur
Sunil
S
Kaplan
Felicity
F
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000368:Aged; D005260:Female; D006099:Granuloma / Q000150:complications* / Q000601:surgery; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000601:surgery; D010279:Parathyroid Diseases / Q000150:complications* / Q000601:surgery; D010280:Parathyroid Glands / Q000473:pathology / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000601:surgery; D016105:Parathyroidectomy; D012507:Sarcoidosis / Q000150:complications* / Q000601:surgery; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000150:complications*