title: Stent thrombosis--risk assessment and prevention.
abstract: The development and use of stents has made percutaneous coronary intervention an effective (less restenosis), safe (treatment of emergency vessel closure during balloon angioplasty), and applicable (stents were developed for lesions of tortuous anatomy and complex situations) revascularization method. These features have firmly established stenting as first-line therapy in coronary revascularization. This life-saving device carries, however, the risk of a life-threatening complication--stent thrombosis. The article summarizes the facts about the incidence, histopathology, and risk factors of bare-metal as well as drug-eluting stent thrombosis. Future directions in reducing the incidence of stent thrombosis are also outlined.
authors.affiliation: Third Medical Faculty, Charles University and University Hospital, Kralovske Vinohrady, Prague, Czech Republic. zuzana.motovska@iex.cz
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Motovska
authors.forename: Jiri
authors.initials: J
authors.lastname: Knot
authors.forename: Petr
authors.initials: P
authors.lastname: Widimsky
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation*; D000818:Animals; D003324:Coronary Artery Disease / Q000628:therapy*; D054855:Drug-Eluting Stents; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D008670:Metals; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011474:Prosthesis Design; D018570:Risk Assessment; D012307:Risk Factors; D015607:Stents; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D008670:Metals; D010975:Platelet Aggregation Inhibitors