title: Health-related quality of life after ischemic stroke: the impact of pharmaceutical interventions on drug therapy (pharmaceutical care concept).
abstract: BACKGROUND
  Health-related quality of life (HRQoL) after stroke is an important healthcare measure. Pharmaceutical Care (PC) is an evolving concept to optimize drug-therapy, minimize drug-related problems, and improve HRQoL of patients. The purpose of this study was to evaluate the impact of PC on HRQoL, as determined by Short Form 36 (SF-36) among patients after TIA or ischemic stroke one-year following their initial entry in hospital.
  
  
  METHODS
  Patients were assigned to either an intervention (IG) or a control group (CG). The individual assignment of the patient to IG or CG depended on the community pharmacy to which the patients were assigned for care. Community pharmacies either delivered standard care (CG) or provided intensified PC (IG). Pharmacists who are members of the "Quality Assurance Working Group" (QAWG) provided PC for patients in IG.
  
  
  RESULTS
  255 patients were recruited (IG: n = 90; CG: n = 165) between 06/2004 to 01/2007. During the study, the HRQoL of the patients in IG did not change significantly. In the CG, a significant decrease in the HRQoL was observed in 7/8 subscales and in both summary measures of SF-36.
  
  
  CONCLUSIONS
  This is the first follow-up study in Germany involving a major community hospital, rehabilitation hospitals, community pharmacies and general practitioners investigating the impact of PC on HRQoL of patients after ischemic stroke. Our findings indicate that an intensified education and care of patients after ischemic stroke by dedicated pharmacists based on a concept of PC may maintain the HRQoL of IG patients.
authors.affiliation: Klinikum Fulda gAG, Department of Neurology, Pacelliallee 4, 36043 Fulda, Germany. carina.hohmann@klinikum-fulda.de
authors.forename: Carina
authors.initials: C
authors.lastname: Hohmann
authors.forename: Roland
authors.initials: R
authors.lastname: Radziwill
authors.forename: Juergen M
authors.initials: JM
authors.lastname: Klotz
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Jacobs
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006305:Health Status Indicators; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011785:Quality Assurance, Health Care; D011788:Quality of Life; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy* / Q000628:therapy