title: Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease.
abstract: The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities in patients with Alzheimer's disease (AD). Fifty patients with AD and fifty healthy control subjects were included in this study. Plasma Cu and Zn concentrations by atomic absorption spectrometry (AAS), plasma Mg and Fe concentrations by spectrophotometric methods and plasma Se concentrations by graphite furnace AAS were determined. Erythrocyte GPx, SOD and CAT activities were measured by spectrophotometric methods. Plasma Mg, Cu, Zn, Fe and Se levels and erythrocyte GPx, SOD and CAT activities were found to be significantly lower in patients with AD compared with controls. These results suggest that alterations in essential trace elements and their related enzymes may play a role in the etiopathogenesis of AD. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with AD. The changes in antioxidant enzyme activities may be secondary to the alterations in their cofactor concentrations.
authors.affiliation: Department of Biochemistry, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey. vuralh@yahoo.com
authors.forename: Huseyin
authors.initials: H
authors.lastname: Vural
authors.forename: Hilmi
authors.initials: H
authors.lastname: Demirin
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Kara
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Eren
authors.forename: Namik
authors.initials: N
authors.lastname: Delibas
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000201:enzymology*; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D003300:Copper / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D003300:Copper; D007501:Iron; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D008274:Magnesium; D015032:Zinc