title: In vitro antimicrobial activity of gallium maltolate against virulent Rhodococcus equi.
abstract: The objective of this study was to determine the in vitro antimicrobial activity of gallium maltolate (GaM) against Rhodococcus equi. A total of 98 virulent bacterial isolates from equine clinical cases were examined, of which 19 isolates were known to be resistant to macrolides and rifampin. Isolates were cultured with various concentrations of GaM and minimal inhibitory concentration (MIC) values were determined after 24 and 48 h. Both the MIC(50) and the MIC(90) after 24h of growth were 558 ng/mL (8 μM) and after 48 h of growth were 2230 ng/mL (32 μM). There were no apparent differences between MICs of macrolide-resistant and macrolide-susceptible isolates.
authors.affiliation: Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX 77845, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Coleman
authors.forename: Kyle
authors.initials: K
authors.lastname: Kuskie
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Keith
authors.initials: K
authors.lastname: Chaffin
authors.forename: Melissa
authors.initials: M
authors.lastname: Libal
authors.forename: Steeve
authors.initials: S
authors.lastname: Giguère
authors.forename: Lawrence
authors.initials: L
authors.lastname: Bernstein
authors.forename: Noah
authors.initials: N
authors.lastname: Cohen
mesh_terms: D000193:Actinomycetales Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy* / Q000382:microbiology; D006736:Horses; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011753:Pyrones / Q000627:therapeutic use*; D016929:Rhodococcus equi / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D011753:Pyrones; C512662:gallium maltolate