title: Cellulose diacetate-g-poly(p-dioxanone) co-polymer: synthesis, properties and microsphere preparation.
abstract: A novel biodegradable graft co-polymer based on cellulose diacetate (CDA) and poly(p-dioxanone) was synthesized by ring-opening polymerization of p-dioxanone (PDO). The molecular structure of co-polymers was characterized by one- and two-dimensional NMR. The graft co-polymers with different lengths of PPDO side-chains could be controllably synthesized by changing the in-feed ratio of CDA/PDO. It was found that the PPDO content had great effect on the thermal transition behavior, crystallization ability and thermal stability of the graft co-polymer. The in vitro degradation rates of CDA-g-PPDO were higher than that of linear PPDO due to their lower crystallinity. Moreover, porous microspheres of graft co-polymers with a diameter of about 5 μm, prepared through the solvent evaporation of water-in-oil emulsion (W/O), indicated it may have potential applications in drug-delivery systems.
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, Chengdu 610064, P R China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Hai-Chun
authors.initials: HC
authors.lastname: Dang
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Wang
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008863:Microspheres; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D011108:Polymers; C079733:poly-4-dioxan-2-one; D002482:Cellulose; C026170:cellulose diacetate