title: NIAID workshop on Flavivirus immunity.
abstract: On September 16, 2009, the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health, convened a workshop to discuss current knowledge of T- and B-cell immune epitopes for members of the Flavivirus genus (family Flaviviridae), and how this information could be used to increase our basic understanding of host-pathogen interactions and/or advance the development of new or improved vaccines and diagnostics for these pathogens. B-cell and T-cell responses to flaviviruses are critical components of protective immunity against these pathogens. However, they have also been linked to disease pathogenesis. A detailed understanding of the biological significance of immune epitope information may provide clues regarding the mechanisms governing the induction of protective versus pathogenic adaptive immune responses.
authors.affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-6601, USA. augustine@niaid.nih.gov
authors.forename: Alison D
authors.initials: AD
authors.lastname: Augustine
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Cassetti
authors.forename: Francis A
authors.initials: FA
authors.lastname: Ennis
authors.forename: Eva
authors.initials: E
authors.lastname: Harris
authors.forename: William H
authors.initials: WH
authors.lastname: Hildebrand
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Repik
mesh_terms: D035843:Biomedical Research / Q000639:trends*; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D005416:Flavivirus / Q000276:immunology*; D018177:Flavivirus Infections / Q000276:immunology / Q000517:prevention & control; D054884:Host-Pathogen Interactions; D006801:Humans; D054579:National Institute of Allergy and Infectious Diseases (U.S.); D014481:United States; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D014765:Viral Vaccines