title: Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis.
abstract: OBJECTIVE
  To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA).
  
  
  METHODS
  Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements.
  
  
  RESULTS
  A statistically significant interaction was observed between IL6R rs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status.
  
  
  CONCLUSIONS
  The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.
authors.affiliation: Rheumatology Service, Hospital Clínico San Carlos, 28040 Madrid, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Lamas
authors.forename: Luis
authors.initials: L
authors.lastname: Rodríguez-Rodríguez
authors.forename: Jezabel
authors.initials: J
authors.lastname: Varadé
authors.forename: Pedro
authors.initials: P
authors.lastname: López-Romero
authors.forename: Pilar
authors.initials: P
authors.lastname: Tornero-Esteban
authors.forename: Lydia
authors.initials: L
authors.lastname: Abasolo
authors.forename: Elena
authors.initials: E
authors.lastname: Urcelay
authors.forename: Benjamín
authors.initials: B
authors.lastname: Fernández-Gutiérrez
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000097:blood*; D020641:Polymorphism, Single Nucleotide; D019947:Receptors, Interleukin-6 / Q000097:blood / Q000235:genetics*; D012720:Severity of Illness Index; D015398:Signal Transduction
chemical_list: C508603:IL6R protein, human; D010456:Peptides, Cyclic; D019947:Receptors, Interleukin-6; C487763:cyclic citrullinated peptide