title: Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin.
abstract: BACKGROUND
  Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder.
  
  
  METHODS
  To investigate their biological basis, we examined the possible association between 164 single nucleotide polymorphisms (SNPs) in the 8q24 risk regions spanning 128,101,433-128,828,043 bp, and serum androgen (testosterone, androstenedione, 3alphadiol G, and bioavailable testosterone), and sex hormone-binding globulin levels in 563 healthy, non-Hispanic, Caucasian men (55-74 years old) from a prospective cohort study (the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial). Age-adjusted linear regression models were used to determine the association between the SNPs in an additive genetic model and log-transformed biomarker levels.
  
  
  RESULTS
  Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 x 10(-3)) and bioavailable testosterone (P < 6.3 x 10(-4)). Suggestive associations were seen for a cluster of nine SNPs in prostate cancer risk region 1 and androstenedione (P < 0.05).
  
  
  CONCLUSIONS
  These preliminary findings require confirmation in larger studies but raise the intriguing hypothesis that genetic variations in the 8q24 cancer risk regions might correlate with androgen levels.
  
  
  CONCLUSIONS
  These results might provide some clues for the strong link between 8q24 and prostate cancer risk.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Lisa W
authors.initials: LW
authors.lastname: Chu
authors.forename: Tamra E
authors.initials: TE
authors.lastname: Meyer
authors.forename: Qizhai
authors.initials: Q
authors.lastname: Li
authors.forename: Idan
authors.initials: I
authors.lastname: Menashe
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Philip S
authors.initials: PS
authors.lastname: Rosenberg
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Huang
authors.forename: Sabah M
authors.initials: SM
authors.lastname: Quraishi
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Jocelyn M
authors.initials: JM
authors.lastname: Weiss
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Ann W
authors.initials: AW
authors.lastname: Hsing
mesh_terms: D000368:Aged; D000728:Androgens / Q000097:blood*; D002898:Chromosomes, Human, Pair 8; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
chemical_list: D000728:Androgens; D012738:Sex Hormone-Binding Globulin