Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia pinnata.
A study of the components of the fruits of Kigelia pinnata was undertaken to identify compounds with potential growth inhibitory activity against human melanoma cells, since extracts from the fruits of this plant have been described in traditional medicine to have application in the treatment of skin cancer and other skin ailments. A bioactivity-guided fractionation process yielded a number of crude fractions, which demonstrated cytotoxicity in vitro against human melanoma cells. Compounds isolated and identified included the isocoumarins, demethylkigelin (1) and kigelin (2), fatty acids, oleic (3) and heneicosanoic acids (4), the furonaphthoquinone, 2-(1-hydroxyethyl)-naphtho[2,3-b]furan-4,9-dione (5), and ferulic acid (6). A number of structurally related synthetic compounds were also tested using the MTT assay. The most potent series of these compounds, the furonaphthoquinones, also demonstrated a cytotoxic effect in two human breast cancer cell lines tested.
Higgins
Catherine A
CA
Centre for Cancer Research and Cell Biology (CCRCB), Queens University Belfast, Belfast, Ireland. c.a.higgins@qub.ac.uk
Bell
Tanachat
T
Delbederi
Zoica
Z
Feutren-Burton
Stéphanie
S
McClean
Barry
B
O'Dowd
Colin
C
Watters
William
W
Armstrong
Paul
P
Waugh
David
D
van den Berg
Hendrik
H
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D029402:Bignoniaceae / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D005260:Female; D005638:Fruit / Q000737:chemistry; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; D009285:Naphthoquinones; D010936:Plant Extracts