title: A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis.
abstract: A new protoberberine alkaloid, 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxo-protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine-induced contraction in isolated guinea-pig ileum with an IC50 of 83.7 microm.
authors.affiliation: School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Xian
authors.forename: Siu-Po
authors.initials: SP
authors.lastname: Ip
authors.forename: Harry Hs
authors.initials: HH
authors.lastname: Fong
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Che
mesh_terms: D000109:Acetylcholine; D000818:Animals; D001600:Berberine Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D039323:Coptis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome
chemical_list: C556510:3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxoprotoberberine; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D010276:Parasympatholytics; D000109:Acetylcholine