Regulation of innate immune responses by autophagy-related proteins.
Pattern recognition receptors detect microbial components and induce innate immune responses, the first line of host defense against infectious agents. However, aberrant activation of immune responses often causes massive inflammation, leading to the development of autoimmune diseases. Therefore, both activation and inactivation of innate immune responses must be strictly controlled. Recent studies have shown that the cellular machinery associated with protein degradation, such as autophagy, is important for the regulation of innate immunity. These studies reveal that autophagy-related proteins are involved in the innate immune response and may contribute to the development of inflammatory disorders.
Saitoh
Tatsuya
T
Laboratory of Host Defense, World Premiere International Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Akira
Shizuo
S
D000818:Animals; D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D001343:Autophagy / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology; D010588:Phagosomes / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
D000941:Antigens; D001426:Bacterial Proteins; D053472:Nod Signaling Adaptor Proteins; D051193:Toll-Like Receptors