Anti-osteoporotic constituents from Indian medicinal plants.
The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.
Kumar
Manmeet
M
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, M. G. Road, Lucknow 226001, Uttar Pradesh, India.
Rawat
Preeti
P
Dixit
Preeti
P
Mishra
Devendra
D
Gautam
Abnish K
AK
Pandey
Rashmi
R
Singh
Divya
D
Chattopadhyay
Naibedya
N
Maurya
Rakesh
R
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D032422:Cissus; D007194:India; D010006:Osteoblasts / Q000187:drug effects* / Q000502:physiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D029631:Sapindaceae; D020950:Vitex
D050071:Bone Density Conservation Agents; D010936:Plant Extracts