title: Influence of short-term exposure to ultrafine and fine particles on systemic inflammation.
abstract: Daily to monthly variations in fine particulate matter have been linked to systemic inflammatory responses. It has been hypothesized that smaller particles resulting from combustion processes confer higher toxicity. We aim to analyze the association between short-term exposure to ultrafine and fine particles and systemic inflammation. We use baseline data (2000-2003) of the Heinz Nixdorf Recall Study, a population-based cohort study of 4,814 participants in the Ruhr Area in Germany. A chemistry transport model was applied to model daily surface concentrations of particulate air pollutants on a grid of 1 km(2). Exposure included particle number (PN) and particulate matter mass concentration with an aerodynamic diameter < or = 2.5 microm (PM(2.5)) and < or = 10 microm (PM(10)). Generalized additive models were used to explore the relation of air pollutants using single day lags and averaging times of up to 28 days with high-sensitivity C-reactive protein (hs-CRP). We adjusted for meteorology, season, time trend, and personal characteristics. Median hs-CRP level in the 3,999 included participants was 1.5 mg/l. Median daily concentration of PN was 8,414 x 10(4)/ml (IQR 4,580 x 10(4)/ml), of PM(2.5) 14.5 microg/m(3) (IQR 11.5 microg/m(3)) and of PM(10) 18.5 microg/m(3) (IQR 13.9 microg/m(3)). A positive association between PN and hs-CRP could be observed only for single day lags and for averaged PN concentrations with higher estimates for longer averaging times. The highest hs-CRP-increase of 7.1% (95%-CI: 1.9, 12.6%) was found for the 21-day average. These results support the hypothesis that short-term exposure to traffic-related particles might lead to detrimental cardiovascular health effects via an inflammatory mechanism.
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Hufelandstr. 55, 45122, Essen, Germany. sabine.hertel@uk-essen.de
authors.forename: Sabine
authors.initials: S
authors.lastname: Hertel
authors.forename: Anja
authors.initials: A
authors.lastname: Viehmann
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.forename: Klaus
authors.initials: K
authors.lastname: Mann
authors.forename: Martina
authors.initials: M
authors.lastname: Bröcker-Preuss
authors.forename: Stefan
authors.initials: S
authors.lastname: Möhlenkamp
authors.forename: Michael
authors.initials: M
authors.lastname: Nonnemacher
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.forename: Hermann
authors.initials: H
authors.lastname: Jakobs
authors.forename: Michael
authors.initials: M
authors.lastname: Memmesheimer
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Jöckel
authors.forename: Barbara
authors.initials: B
authors.lastname: Hoffmann
mesh_terms: D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology*; D013997:Time Factors; D014504:Urban Health
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D052638:Particulate Matter; D002097:C-Reactive Protein