Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.
Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.
Thalji
Reema K
RK
Department of Chemistry, Infectious Diseases Centre for Excellence in Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. reema.k.thalji@gsk.com
Aiyar
Nambi
N
Davenport
Elizabeth A
EA
Erhardt
Joseph A
JA
Kallal
Lorena A
LA
Morrow
Dwight M
DM
Senadhi
Shobha
S
Burns-Kurtis
Cynthia L
CL
Marino
Joseph P
JP
D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology; D015539:Platelet Activation / Q000187:drug effects; D058921:Purinergic P2Y Receptor Antagonists / Q000737:chemistry* / Q000494:pharmacology; D058472:Receptors, Purinergic P2Y1 / Q000378:metabolism*; D014508:Urea / Q000737:chemistry* / Q000494:pharmacology
D001572:Benzofurans; D058921:Purinergic P2Y Receptor Antagonists; D058472:Receptors, Purinergic P2Y1; D014508:Urea; C105430:benzofuran