title: [Stroke revealing granulomatosis].
abstract: BACKGROUND
  Central nervous system involvement is rare in Wegener granulomatosis. Stroke is the most common event suggestive of the disease.
  
  
  CONCLUSIONS
  A 35-year-old woman, who was followed for rhinitis and mild asthma, described gradual decline of visual acuity in the right eye over two months, persistent nasal obstruction and fronto-orbital headache since a few weeks. She presented left hemiparesis due to a stroke, associated with exophthalmos and deficits of the optic nerve and abducens of the right eye. The otolaryngological examination found signs of crusty rhinitis and right nasal stenosis. The diagnosis of Wegener's granulomatosis was established on the basis of the clinical findings, radiological aspects and the presence of ANCA. The patient was treated by antiplatelet agents and high-dose corticosteroids associated with immunosuppressive drugs including cyclophosphamide in a monthly bolus.
  
  
  CONCLUSIONS
  This case illustrates two of the three pathogenic mechanisms that may account for central nervous system involvement in Wegener granulomatosis: vasculitis, extension by contiguity of granulomatous tissue from the nasal cavity or sinuses, and in situ formation of a granuloma into the brain parenchyma or meninges.
authors.affiliation: Service de neurologie B et de neurogénétique, hôpital des spécialités de Rabat, Rabat, Maroc.
authors.forename: L
authors.initials: L
authors.lastname: Raissouni
authors.forename: E
authors.initials: E
authors.lastname: Aitbenhaddou
authors.forename: N
authors.initials: N
authors.lastname: Ahbeddou
authors.forename: K T
authors.initials: KT
authors.lastname: El Alaoui
authors.forename: C
authors.initials: C
authors.lastname: Slimani
authors.forename: A
authors.initials: A
authors.lastname: Benomar
authors.forename: M
authors.initials: M
authors.lastname: Yahyaoui
mesh_terms: D020434:Abducens Nerve Diseases / Q000209:etiology; D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D002545:Brain Ischemia / Q000209:etiology*; D002540:Cerebral Cortex / Q000098:blood supply; D003342:Corpus Striatum / Q000098:blood supply; D003520:Cyclophosphamide / Q000627:therapeutic use; D005094:Exophthalmos / Q000209:etiology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D015508:Nasal Obstruction / Q000209:etiology; D009408:Nerve Compression Syndromes / Q000209:etiology; D009901:Optic Nerve Diseases / Q000209:etiology; D010291:Paresis / Q000209:etiology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone