Longevity mutants do not establish any "new science" of ageing.
The biological reasons for ageing are now well known, so it is no longer an unsolved problem in biology. Furthermore, there is only one science of ageing, which is continually advancing. The significance and importance of the mutations that lengthen the lifespan of invertebrates can be assessed only in relationship to previous well-established studies of ageing. The mutant strains of model organisms that increase longevity have altered nutrient signalling pathways similar to the effects of dietary restriction, and so it is likely that there is a shift in the trade-off between reproduction and maintenance of the soma. To believe that the isolation and characterisation of a few invertebrate mutations (as well as those in yeast) will "galvanise" the field and provide new insights into human ageing is an extreme point of view which does not recognize the huge progress in ageing research that has been made in the last 50 years or so.
Holliday
Robin
R
Australian Academy of Sciences, West Pennant Hills, NSW, Australia.
Rattan
Suresh I S
SI
D000375:Aging / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008136:Longevity / Q000235:genetics*; D009154:Mutation; D012098:Reproduction / Q000235:genetics