title: Intraoperative radiotherapy and colorectal cancer.
abstract: Intraoperative radiotherapy (IORT) is a highly specialized component of multidisciplinary management of advanced and recurrent colorectal cancer. The aim of this review was to assess its role and effectiveness in the management of colorectal cancer. A literature search was performed using Medline, Embase, Ovid and Cochrane to identify English language studies which have used IORT in the multidisciplinary management of primary and recurrent colon and rectal cancers. Improved survival and local control in patients with involved surgical margins treated with IORT have been shown in many studies, but these results have been mainly from retrospective studies. There is associated morbidity from IORT. IORT does have a role in the management of colorectal cancer. Further research needs to be performed to optimize the application of this therapy.
authors.affiliation: Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: J M C
authors.initials: JM
authors.lastname: Yeung
authors.forename: S
authors.initials: S
authors.lastname: Ngan
authors.forename: C
authors.initials: C
authors.lastname: Lynch
authors.forename: A G
authors.initials: AG
authors.lastname: Heriot
mesh_terms: D015179:Colorectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D007430:Intraoperative Care; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery