Recent advances in the study of candidate genes for adolescent idiopathic scoliosis.
We used a microarray approach to evaluate gene expression profiles in human AIS osteoblasts, and to identify genes that are differentially expressed following estrogen exposure in non-AIS and AIS human osteoblasts. We found that more than one gene is likely responsible for AIS. Furthermore, some of these genes are estrogen-regulated, suggesting a possible role of estrogens in the etiology of scoliosis.
Fendri
K
K
CHU Sainte Justine and Université de Montréal, Montreal, Canada.
Patten
S
S
Zaouter
C
C
Parent
S
S
Kaufman
G
G
Labelle
H
H
Edery
P
P
Moldovan
F
F
D000293:Adolescent; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D036281:Genetic Research; D006801:Humans; D012600:Scoliosis / Q000209:etiology / Q000235:genetics*