Stem cells in the diabetic infarcted heart.
Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate.
Glass
Carley E
CE
Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida BLVD, Room 224, Orlando, FL 32816, USA.
Singal
Pawan K
PK
Singla
Dinender K
DK
D000818:Animals; D048909:Diabetes Complications / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology; D009203:Myocardial Infarction / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D032383:Myocytes, Cardiac / Q000637:transplantation*; D018384:Oxidative Stress; D033581:Stem Cell Transplantation; D016896:Treatment Outcome