(R)evolution of complex regulatory systems.
Signaling systems are exciting to study precisely because they are some of the most complex and dynamical systems that we know. The cell needs operational freedom and, thus, many motif-domain interactions might not be "hard-wired" through evolution, but instead may be like the Linux operating system, where symbolic links can point to files without duplication.
Linding
Rune
R
D001695:Biology / Q000379:methods / Q000639:trends; D002468:Cell Physiological Phenomena; D004777:Environment; D005818:Genetic Engineering / Q000639:trends; D006706:Homeostasis / Q000502:physiology*; D010766:Phosphorylation; D020543:Proteome / Q000378:metabolism; D015398:Signal Transduction; D013561:Symbolism
D020543:Proteome