title: ROCK: a breast cancer functional genomics resource.
abstract: The clinical and pathological heterogeneity of breast cancer has instigated efforts to stratify breast cancer sub-types according to molecular profiles. These profiling efforts are now being augmented by large-scale functional screening of breast tumour cell lines, using approaches such as RNA interference. We have developed ROCK ( rock.icr.ac.uk ) to provide a unique, publicly accessible resource for the integration of breast cancer functional and molecular profiling datasets. ROCK provides a simple online interface for the navigation and cross-correlation of gene expression, aCGH and RNAi screen data. It enables the interrogation of gene lists in the context of statistically analysed functional genomic datasets, interaction networks, pathways, GO terms, mutations and drug targets. The interface also provides interactive visualisations of datasets and interaction networks. ROCK collates data from a wealth of breast cancer molecular profiling and functional screening studies into a single portal, where analysed and annotated results can be accessed at the level of a gene, sample or study. We believe that portals such as ROCK will not only afford researchers rapid access to profiling data, but also aid the integration of different data types, thus enhancing the discovery of novel targets and biomarkers for breast cancer.
authors.affiliation: Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK.
authors.forename: David
authors.initials: D
authors.lastname: Sims
authors.forename: Borisas
authors.initials: B
authors.lastname: Bursteinas
authors.forename: Qiong
authors.initials: Q
authors.lastname: Gao
authors.forename: Ekta
authors.initials: E
authors.lastname: Jain
authors.forename: Alan
authors.initials: A
authors.lastname: MacKay
authors.forename: Costas
authors.initials: C
authors.lastname: Mitsopoulos
authors.forename: Marketa
authors.initials: M
authors.lastname: Zvelebil
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D055028:Comparative Genomic Hybridization; D003196:Computer Graphics; D030541:Databases, Genetic; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D023281:Genomics; D005838:Genotype; D006801:Humans; D009154:Mutation; D010641:Phenotype; D011379:Prognosis; D034622:RNA Interference; D014584:User-Computer Interface