Correlation between the Indexes of Insulin Resistance and Renal Function in the Presence of Hypertension.
OBJECTIVE
It is important to establishthe association between insulin resistance and renal function; however, the reported associations differ across studies. Different underlying pathophysiologies of the studied populations may affect the associations. There have been no reports on the relationship between insulin resistance and renal function in the presence of hypertension (HT). We investigated the correlation between a homeostasis model assessment of insulin resistance (HOMA-IR) and the estimated glomerular filtration rate (eGFR) in subjects with and without HT.


METHODS
The study included 214 individuals (mean age: 65.6 years) who were nonmedicated and cardiovascular disease-free. Clinical variables, including blood pressure (BP), creatinine, glucose and lipid panels, were measured.


RESULTS
The HT group showed significantly higher levels of systolic/diastolic BP than the non-HT group. A multiple linear regression analysis revealed that the eGFR in the non-HT group was independently, significantly and inversely correlated with HOMA-IR, while the eGFR in the HT group was independently, significantly and inversely correlated with systolic BP, but not with HOMA-IR.


CONCLUSIONS
A clearer correlation between HOMA-IR and eGFR was observed in the non-HT group than the HT group, suggesting that HT may attenuate the direct correlation between the insulin resistance and renal function indices.
Matsunaga
Hiroaki
H
Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Japan.
Kotani
Kazuhiko
K
Taniguchi
Nobuyuki
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged