Lessons from models of pancreatic beta cells for engineering glucose-sensing cells.
Mathematical models of pancreatic beta cells suggest design principles that can be applied to engineering cells to sense glucose and secrete insulin. Engineering cells can potentially both contribute to future diabetes therapies and generate new insights into beta-cell function. The focus is on ion channels, Ca(2+)handling, and elements of metabolism that combine to produce the varied oscillatory patterns exhibited by beta cells.
Sherman
Arthur
A
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Biological Modeling, Bethesda, MD 20892-5621, USA. asherman@nih.gov
D000818:Animals; D057005:Bioengineering; D020013:Calcium Signaling / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008954:Models, Biological
D005947:Glucose