title: Acanthomatous ameloblastoma in dogs treated with intralesional bleomycin.
abstract: Acanthomatous ameloblastoma (AA) is a benign gingival tumour that often invades bone. This retrospective study evaluated the efficacy of intralesional (IL) bleomycin as a treatment for AA. Six dogs received weekly or bimonthly IL bleomycin injections (dose range, 10-20 U m(-2)). A seventh dog presented with advanced, nonresectable AA was treated palliatively. One to sixteen treatments were administered (median, 5). Six of the seven dogs had a complete response within 4 months from initial IL injection (median, 1.5 months), whereas the palliative case had approximately 25% decrease in tumour volume 14 days from initial injection. Local recurrence was not observed during the study period, with a median follow-up time of 842 days. Adverse effects were limited to wound formation with bone exposure (n = 4), mild tissue reactions (n = 3), local swelling (n = 2) and local infection (n = 1). The conclusions of this study show IL bleomycin is an effective treatment for canines with AA.
authors.affiliation: Veterinary Cancer Care, Santa Fe, NM, USA. Info@vetcancercare.com
authors.forename: J M
authors.initials: JM
authors.lastname: Kelly
authors.forename: B A
authors.initials: BA
authors.lastname: Belding
authors.forename: A K
authors.initials: AK
authors.lastname: Schaefer
mesh_terms: D000564:Ameloblastoma / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005887:Gingival Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D015552:Injections, Intralesional / Q000662:veterinary; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin