[Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging].
The effect of short peptides T-32, T-38 and cardiogen on the expression of signaling factors of the differentiation of human prostate's fibroblasts (PFM), which are the main cells of its microenvironment--protein CXCL12, WEDC1 and ghrelin in aging cultures has been studied. Confocal laser microscopy has demonstrated that all the investigated peptides possess the ability to actively enhance the expression of the above markers, whose synthesis significantly reduced in senescent cultures. It has been shown that the rate of expression of the studied factors in older cultures (after 7 passages) under the action of the peptides have a tendency to even higher than those of controls (young culture, after 1 passage). Thus, peptide T-38 is the most active among the investigated ones. These studies show promise for detailed development of methods of peptides' regulation of aging and age-correction of violations of functioning of the prostate gland.
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D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D016922:Cellular Senescence; D054377:Chemokine CXCL12 / Q000096:biosynthesis; D018920:Coculture Techniques; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D054439:Ghrelin / Q000096:biosynthesis; D006801:Humans; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000096:biosynthesis*
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D054439:Ghrelin; D010455:Peptides; D014157:Transcription Factors