title: Humoral immunity following chickenpox is influenced by geography and ethnicity.
abstract: OBJECTIVE
  To investigate the contribution of ethnicity and geographical location to varicella-zoster virus (VZV) serostatus and antibody concentrations.
  
  
  METHODS
  The presence and concentrations of antibodies to VZV were measured in 639 Bangladeshi women born in Bangladesh (BBB), 94 Bangladeshi women born in the UK (BUK) and 262 White women born in the UK (WUK). The results were analysed in relation to demographic and social data.
  
  
  RESULTS
  BBB women were significantly less likely to be VZV seropositive at all ages than both BUK and WUK women. However, the odds of a Bangladeshi-born woman being seropositive increased by 1.04 for each year under the age of 15 spent in the UK. In contrast, antibody concentrations were significantly lower in ethnic Bangladeshi women, irrespective of country of birth. White, but not Bangladeshi women, showed evidence of antibody boosting over time despite the latter having more exposure to children.
  
  
  CONCLUSIONS
  Geographical location during childhood is the major influence on age of primary infection with VZV while the level of antibody is related to ethnicity. Since the risk of re-infection with VZV following both natural infection and vaccination is increased as antibody concentrations fall, these results have implications for VZV vaccination programmes particularly in non-White populations.
authors.affiliation: Applied Statistics, The University of Reading, Philip Lyle Building, Whiteknights, Reading RG6 6BX, UK.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Ayres
authors.forename: Yamima
authors.initials: Y
authors.lastname: Talukder
authors.forename: Judith
authors.initials: J
authors.lastname: Breuer
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D001459:Bangladesh / Q000208:ethnology; D002644:Chickenpox / Q000208:ethnology* / Q000276:immunology*; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005843:Geography; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D012044:Regression Analysis; D006113:United Kingdom / Q000208:ethnology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral