[Red blood cells hemolysis under combined action of ultrasonic waves and polyene antibiotics].
Ultrasonic and induced hemolysis of red blood cells in the presence of alkyl derivatives of amphotericin B and levorin modified by the amino and carboxy groups was investigated. Amphotericin B derivatives such as metamphocin, ethamphocin and carboamphocin and levorin derivatives such as levoridon, isolevoridon and carbolevoridon were shown to have their own hemolytic activity in isotonic medium at concentrations of 10(-5) - 10(-4) M in erythrocyte suspension. The exposure of erythromycytes to pure dimethylsulfoxide (0.1-30%), the main solvent of polyene antibiotics, as well as to propamphocin and butamphocin did not induce hemolysis and had a stabilizing action an red blood cells during the ultrasonic hemolysis. It was suggested that changing of the mechanical strength of erythrocytes under the action of the polyenes was likely associated with impairment of microviscosity of the protein-lipid system of the erythrocyte membranes due to formation of structural ionic channels of molecular size.
Sultanova
G G
GG
Samedova
A A
AA
Kasumov
Kh M
KhM
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004912:Erythrocytes / Q000737:chemistry* / Q000187:drug effects*; D006461:Hemolysis; D006801:Humans; D014465:Ultrasonics
D000900:Anti-Bacterial Agents; D000666:Amphotericin B