[Effect of Jimaitong tablet combined with nifedipine on blood-pressure and mechanisms investigation in spontaneously hypertensive rats].
OBJECTIVE
To study the effect and its mechanism of antihypertensive of drug combination of Jimaitong tablt and nifedipine on spontaneously hypertensive rats.


METHODS
The spontaneously hypertensive rats (SHR) were treated by intragastric administration (ig) with Jimaitong (450 mg x kg(-1)), Jimaitong (300 mg x kg(-1)) combined with the nifedipine (0.5 mg x kg(-1)), nifedipine (5 mg x kg(-1)) for 8 weeks. Blood pressure and heart rate was measured. The level of oxidation indicators, lipid indicators, as well as hormones related to blood pressure was detected.


RESULTS
Compared with that in the control group, systolic blood pressure, diastolic blood pressure, mean arterial pressure of SHR decreased significantly in all the three administration groups (P < 0.01). Heart rates of nifedipine group was faster than other groups (P < 0.05). In combination group, contents of URE, MDA, ET and Ang II were decreased significantly (P < 0.05, P < 0.05, P < 0.05, P < 0.01), the contents of NO and CAMP, SOD and NOS were significantly enhanced (P < 0.05).


CONCLUSIONS
Combination use of Jimaitong and nifedipine has synergistic effects on anti-hypertension in spontaneously hypertensive rats. It indicates the potential applications of combination of traditional Chinese medicine and western medicine for the hypertension treatment.
Lv
Liangzhong
L
Pharmacy of Zhejiang Provincial People Hospital, Hangzhou 310014, China.
Fang
Qingxia
Q
Lv
Guiyuan
G
Yu
Sheng
S
Chen
Suhong
S
Wu
Xiaodong
X
D000804:Angiotensin II / Q000097:blood / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR; D013482:Superoxide Dismutase / Q000097:blood; D013607:Tablets
D000959:Antihypertensive Agents; D004338:Drug Combinations; D013607:Tablets; D000804:Angiotensin II; D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D009543:Nifedipine