title: Evidence for recombination between vaccine and wild-type mumps virus strains.
abstract: Recombination of mumps virus (MuV) has rarely been reported. In this study, phylogenetic and recombination analyses were performed on 30 complete MuV genomes, including 17 vaccine and 13 wild-type strains. One potentially significant recombination event was found to have occurred between the lineage represented by the vaccine strain L3/Russia/Vector (AY508995) as the minor parent and wild MuV strain Drag94 (AY669145) as the major parent, and this led to a recombinant, 9218/Zg98 (EU370206), a wild-type MuV strain isolated from a 3-year-old boy with parotitis. In summary, we found a recombinant of MuV derived from vaccine and wild-type MuV strains.
authors.affiliation: School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China. z0216wen@yahoo.com
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D009107:Mumps / Q000517:prevention & control / Q000821:virology*; D009108:Mumps Vaccine / Q000235:genetics* / Q000302:isolation & purification; D009109:Mumps virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D011995:Recombination, Genetic
chemical_list: D009108:Mumps Vaccine