title: Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives.
abstract: Chroman derivatives exhibited potent inhibitory activity of NF-kappaB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-kappaB and they were also evaluated for cytotoxicity against various cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of the Boc group were introduced additionally and these compounds were also evaluated for SAR.
authors.affiliation: Department of Pharmacy, Chungbuk National University, Chungbuk, Republic of Korea.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Yoseob
authors.initials: Y
authors.lastname: Kim
authors.forename: Hyunjeong
authors.initials: H
authors.lastname: Park
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Jang
authors.forename: Keun Kuk
authors.initials: KK
authors.lastname: Lee
authors.forename: Wonhui
authors.initials: W
authors.lastname: Yi
authors.forename: Jeong-Ah
authors.initials: JA
authors.lastname: Kwak
authors.forename: Song-Gyu
authors.initials: SG
authors.lastname: Park
authors.forename: Hwanmook
authors.initials: H
authors.lastname: Kim
authors.forename: Kiho
authors.initials: K
authors.lastname: Lee
authors.forename: Jong Soon
authors.initials: JS
authors.lastname: Kang
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Han
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Jung
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Jungsook
authors.initials: J
authors.lastname: Cho
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001596:Benzylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002839:Chromans / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001596:Benzylamines; D002839:Chromans; D007211:Indoles; D016328:NF-kappa B; C057812:indoline; C030796:benzylamine