title: The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids.
abstract: The cytochrome P-450 1A1 (CYPA1A) gene plays an important role in the metabolization of estrogen and is therefore a candidate marker for fibroids. In a case-control study, we were unable to demonstrate any association between MSP I CYP1A1 polymorphism and the risk of leiomyoma in Brazilian women.
authors.affiliation: Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Marco Antônio
authors.initials: MA
authors.lastname: Barão
authors.forename: Emerson
authors.initials: E
authors.lastname: Oliveira
authors.forename: Mariano Tamura Vieira
authors.initials: MT
authors.lastname: Gomes
authors.forename: Ismael Dale Cotrim Guerreiro
authors.initials: ID
authors.lastname: da Silva
authors.forename: Marair Gracio Ferreira
authors.initials: MG
authors.lastname: Sartori
authors.forename: Manoel João Batista Castello
authors.initials: MJ
authors.lastname: Girão
authors.forename: Rodrigo de Aquino
authors.initials: Rde A
authors.lastname: Castro
mesh_terms: D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000502:physiology; D019003:Deoxyribonuclease HpaII / Q000378:metabolism; D004958:Estradiol / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000235:genetics; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics / Q000502:physiology*; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000097:blood / Q000235:genetics* / Q000378:metabolism
chemical_list: D004958:Estradiol; D019363:Cytochrome P-450 CYP1A1; D019003:Deoxyribonuclease HpaII