Neuromodulation of decision-making in the addictive brain.
Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.
Fecteau
Shirley
S
Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. sfecteau@bidmc.harvard.edu
Fregni
Felipe
F
Boggio
Paulo S
PS
Camprodon
Joan A
JA
Pascual-Leone
Alvaro
A
D016739:Behavior, Addictive / Q000523:psychology*; D001921:Brain / Q000502:physiology*; D003657:Decision Making; D006801:Humans; D008954:Models, Biological; D018377:Neurotransmitter Agents; D050781:Transcranial Magnetic Stimulation
D018377:Neurotransmitter Agents