Effect of PP-2A on neurite outgrowth in neuronal cells.
Protein phosphatase 2A (PP-2A) has been implicated to be crucial in neural development and the normal function of nervous system. However, little is known about its role in neuritogenesis. In this study, we reported that inhibition of PP-2A strongly suppresses the outgrowth of cell processes only during the initiation stage, while activation of PP-2A promotes extensive outgrowth of long neurites in Neura2A cells and long single axon or multiple axons in hippocampal neurons. Our results indicated that PP-2A may be an important positive regulator in neurite outgrowth, and upregulation PP-2A could be a possible target for the therapy of axonopathy in neural diseases.
Liu
Dan
D
Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Zheng
Hong-Yun
HY
Luo
Zheng-Zhao
ZZ
Wang
Qun
Q
Zhu
Ling-Qiang
LQ
D000818:Animals; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D016501:Neurites / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D055495:Neurogenesis; D019319:Okadaic Acid / Q000494:pharmacology; D054648:Protein Phosphatase 2 / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats
D004791:Enzyme Inhibitors; D019319:Okadaic Acid; D054648:Protein Phosphatase 2