title: Primary aldosteronism and its impact on the generation of arterial hypertension, endothelial injury and oxidative stress.
abstract: Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation/vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA.
authors.affiliation: Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martinez-Aguayo
authors.forename: Cristian A
authors.initials: CA
authors.lastname: Carvajal
authors.forename: Carmen
authors.initials: C
authors.lastname: Campino
authors.forename: Marlene
authors.initials: M
authors.lastname: Aglony
authors.forename: Lillian
authors.initials: L
authors.lastname: Bolte
authors.forename: Hernán
authors.initials: H
authors.lastname: Garcia
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Fardella
mesh_terms: D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D018384:Oxidative Stress