Incidence and clinical significance of bacterial and fungal contamination of the preservation solution in liver transplantation.
A perfusion fluid used in the preservation of the grafted liver represents a medium suitable for microorganism growth. In this observational study, a sample of 232 transplanted livers was collected. Perfusion fluid samples were stored for microbiological analysis from harvested donors. Bacteria were isolated in 91 out of 232 samples, post-operative infections related to contaminated perfusion solution occurred in 13 cases. The contamination rate of the preservation medium appears to be high, but postoperative infections occurs rarely. We suggest periodic detection and a protocol in place designed for antibiotic use for transplanted patients exposed to contaminated perfusion solution.
Audet
M
M
Centre de Chirurgie Viscérale et de Transplantation-Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg-Université Louis Pasteur, Strasbourg, France.
Piardi
T
T
Panaro
F
F
Ghislotti
E
E
Gheza
F
F
Cag
M
M
Jarzembowski
T M
TM
Flicoteaux
H
H
Wolf
P
P
Cinqualbre
J
J
D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D004340:Drug Contamination; D005658:Fungi / Q000145:classification / Q000302:isolation & purification*; D006090:Gram-Negative Bacteria / Q000145:classification / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D009181:Mycoses / Q000453:epidemiology / Q000382:microbiology; D019188:Organ Preservation Solutions / Q000737:chemistry*; D014019:Tissue Donors
D019188:Organ Preservation Solutions