title: Antiviral properties of antineoplastic drugs. From herpes simplex-1 disappearance to a wide antiviral action: a serendipity case report.
abstract: Herein we report the clinical case of a 46 year old female affected by lung cancer and cerebral metastases who showed, one month after the beginning of an oncologic therapy with vinorelbine and cisplatin, the complete remission of periodic (every 15 days) recurrences of herpetic mouth lesions. More than one year after the disappearance of the herpetic lesions, no further evidence of them were found. Subsequently, specific laboratory investigations, together with another case report that is presently in process, showed that vinorelbine, aside from its well known antineoplastic properties, also exerts a powerful antiviral action.
authors.affiliation: Dept. of Pharmacology and Human Physiology, University of Bari, Bari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Debernardis
authors.forename: Gina
authors.initials: G
authors.lastname: Alfonsi
authors.forename: Luigi
authors.initials: L
authors.lastname: Santacroce
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Bottalico
authors.forename: Rosa
authors.initials: R
authors.lastname: Sabatini
authors.forename: Paolo
authors.initials: P
authors.lastname: Flace
authors.forename: Dinu
authors.initials: D
authors.lastname: Vermesan
authors.forename: Pietro
authors.initials: P
authors.lastname: Auteri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sisto
authors.forename: Raffaele
authors.initials: R
authors.lastname: Cagiano
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D015897:Comorbidity; D005260:Female; D006560:Herpes Labialis / Q000188:drug therapy* / Q000453:epidemiology; D018259:Herpesvirus 1, Human; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D014747:Vinblastine; D000077235:Vinorelbine