title: [Normal tissue tolerance to external beam radiation therapy: thyroid].
abstract: The thyroid is the most developed endocrine gland of the body. Due to its anatomical location, it may be exposed to ionizing radiation in external radiotherapy involving head and neck. This review aims to describe the thyroid radiation disorders, probably under-reported in the literature, their risk factors and follow-up procedures. The functional changes after external beam radiation consists mainly of late effects occurring beyond 6 months, and are represented by the clinical and subclinical hypothyroidism. Its incidence is approximately 20 to 30% and it can occur after more than 25 years after radiation exposure. Hyperthyroidism and auto-immune manifestations have been described in a lesser proportion. The morphological changes consist of benign lesions, primarily adenomas, and malignant lesions, the most feared and which incidence is 0.35%. The onset of hypothyroidism depends of the total dose delivered to the gland, and the irradiated. Modern techniques of conformal radiotherapy with modulated intensity could improve the preservation of the thyroid, at the expense of the increase in low doses and the theoretical risk of secondary cancers.
authors.affiliation: Service d'Oncologie-Radiothérapie, Hôpital Européen Georges-Pompidou, Université Paris Descartes, 20 rue Leblanc, 75015 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Berges
authors.forename: Y
authors.initials: Y
authors.lastname: Belkacemi
authors.forename: P
authors.initials: P
authors.lastname: Giraud
mesh_terms: D006801:Humans; D007037:Hypothyroidism / Q000000981:diagnostic imaging / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D011879:Radiotherapy Dosage; D018570:Risk Assessment; D013959:Thyroid Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000166:cytology / Q000473:pathology / Q000528:radiation effects*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology