title: Phenotypic characteristics of enterotoxigenic Escherichia coli associated with acute diarrhea among Israeli young adults.
abstract: Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea among infants and children in developing countries, as well as among travelers to these areas. The major virulence factors of ETEC are the colonization factor antigens (CFAs) and a heat-labile enterotoxin (LT) and/or a heat-stable enterotoxin (ST). Among Israeli recruits serving under military field conditions, 107 of all examined isolates expressed LT or ST, and CFAs could be characterized in 68% of the isolates, in which CFAs of the CFA/II group and CS6 were the most prevalent. Additionally, 31% of the 107 ETEC isolates showed resistance to three or more of the antimicrobial agents examined, and the percentage of resistant isolates expressing LT was significantly higher than those expressing ST or LT+ST. These results may be important for development of an effective vaccine and for facilitation of an empirical choice of antibiotic treatment or prophylaxis for traveler's diarrhea in this area.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, School of Public Health, Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel. dancohen@post.tau.ac.il
authors.forename: Dani
authors.initials: D
authors.lastname: Cohen
authors.forename: Joshua
authors.initials: J
authors.lastname: Tobias
authors.forename: Anya
authors.initials: A
authors.lastname: Spungin-Bialik
authors.forename: Tamar
authors.initials: T
authors.lastname: Sela
authors.forename: Raid
authors.initials: R
authors.lastname: Kayouf
authors.forename: Yael
authors.initials: Y
authors.lastname: Volovik
authors.forename: Miri
authors.initials: M
authors.lastname: Yavzori
authors.forename: Moshe
authors.initials: M
authors.lastname: Ephros
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines; D003967:Diarrhea / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D054307:Enterotoxigenic Escherichia coli / Q000737:chemistry / Q000187:drug effects* / Q000472:pathogenicity*; D004768:Enterotoxins / Q000032:analysis; D004927:Escherichia coli Infections / Q000178:diet therapy / Q000382:microbiology* / Q000517:prevention & control; D005243:Feces / Q000382:microbiology; D036781:Fimbriae Proteins / Q000032:analysis; D006358:Hot Temperature; D006801:Humans; D007557:Israel; D008889:Military Personnel; D010641:Phenotype; D055815:Young Adult
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004768:Enterotoxins; C022924:colonization factor antigens; D036781:Fimbriae Proteins