Total synthesis of cryptoacetalide.
We are reporting the first total synthesis of the tetracyclic terpene natural product cryptoacetalide. Key steps of the synthesis are a microwave-mediated [2+2+2] cyclo-trimerization reaction to construct the central benzene ring, and a light-mediated radical cyclization to assemble the spiro-ketal moiety.
Zou
Yan
Y
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.
Deiters
Alexander
A
D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
D004224:Diterpenes; C553736:cryptoacetalide