Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice.
There is a growing body of evidence that striosome-matrix dopamine systems are tightly linked with motor and behavioral brain functions and disorders. In this study, we used an immunohistochemical method to show differential expression of the olfactory type G-protein alpha subunit (Galphaolf) that involves in the coupling of dopamine D1 receptor with adenylyl cyclase in the striatal compartments of adult mice, and observed heightened density of Galphaolf labeling in the striosomes relative to the matrix compartment. Our findings suggest that Galphaolf could be one of the key molecules for controlling differential responses of the striosome and matrix compartments to dopamine D1 receptor signaling in the striatum of adult mice.
Sako
W
W
Parkinson's Disease and Dystonia Research Center, Tokushima University Hospital, Tokushima 770-8503, Japan; Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.
Morigaki
R
R
Nagahiro
S
S
Kaji
R
R
Goto
S
S
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32 / Q000378:metabolism; D044385:GTP-Binding Protein alpha Subunits / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D017447:Receptors, Dopamine D1 / Q000819:agonists; D017450:Receptors, Opioid, mu / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D044385:GTP-Binding Protein alpha Subunits; C497929:Ppp1r1b protein, mouse; D017447:Receptors, Dopamine D1; D017450:Receptors, Opioid, mu; C084618:olfactory G protein subunit alpha olf; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine; D004298:Dopamine