[Effective analysis of continous perfusion with Dandshen and heparin for treatment of femoral head necrosis].
OBJECTIVE
To investigate the effect of continous perfusion with Danshen and heparin for treatment of femoral head necrosis.


METHODS
From April 2004 to June 2007,42 patients of femoral head necrosis were treated by contious perfusing with Dandshen and heparin, included 24 males and 18 females with an average age of 39.2 years ranging from 13 to 61 years. There were 18 patients on stage II, 13 patients on stage III, 11 patients on stage IV according to Ficat standard. The venous duct were inserted into femoral head then perfused Danshen and heparin into femoral head for 15 days. Every patient was carried out opacification before treatment and 1 month after operation. Every patient was evaluated according to Harris standard before treatment and 3, 6, 12 months after treatment.


RESULTS
All patients were followed-up for 32 to 68 months (means 42.7 months). The average scores of 18 patients on stage II on 3, 6, 12 months after treatment were (88.43 +/- 3.41), (94.37 +/- 3.47), (92.84 +/-4.29), respectively, and the scores after treatment were higher than the score (78.23 +/- 3.47) after treatment. The average scores of 13 cases on stage III on 3, 6, 12 after treatment were (82.94 +/- 3.31), (88.60 +/- 2.31), (86.09 +/- 3.17) respectivly, and the scores after treatment were higher than the score (66.11 +/- 4.50) before treatment. The average scores of 11 cases on stage IV on 3, 6, 12 months after treatment were (61.31 +/- 4.06), (59.2 +/- 7.31), (54.62 +/- 8.20) respectivly,and the scores on 3, 6 months after treatment were higher than the score (50.16 +/- 2.35) before treatment,but there was no obvious difference between before treatment and 12 months after treatment. The rank of phlebography of 18 cases on stage II and 13 cases on stage IlI were improved obvi ously 1 month after treatment,but there was no obvious difference in 11 cases of stage IV.


CONCLUSIONS
The method of contious perfusing with Danshen and heparin into femoral head has the advantage of little damage and good effect. It refers to patients in early stage (II and II ).
Wang
Chang-Xing
CX
Department of Orthopaedics, the Second Hospital of the Zhejiang University of TCM, Hangzhou 310005, Zhejiang, China. wcxing@zj.com
Shen
Jian-Guo
JG
Jiang
Tao
T
Wu
Jian-Min
JM
Dong
Li-Qiang
LQ
Wang
Wei-Dong
WD
D000293:Adolescent; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods*; D010690:Phlebography; D016896:Treatment Outcome; D055815:Young Adult
C550870:Dandshen; D004365:Drugs, Chinese Herbal; D006493:Heparin