title: Synthesis of some novel 2,5-disubstituted thiazolidinones from a long chain fatty acid as possible anti-inflammatory, analgesic and hydrogen peroxide scavenging agents.
abstract: Some new decanoic acid [2,5-disubstituted-4-oxo-thiazolidin-3-yl]amides (6a-j) have been synthesised by the condensation of decanoic acid hydrazide with various aromatic aldehydes to yield the Schiff's bases. Cyclocondensation of the Schiff's bases with thioglycollic acid afforded 4-thiazolidinone derivatives. The structures of the newly synthesised compounds were confirmed by analytical and spectral methods. The anti-inflammatory, analgesic and antioxidant activity of the title compounds were evaluated. Compound 6j exhibited 44.84 % inhibition of inflammation and was the most potent anti-inflammatory agent of the series whereas compound 6f demonstrated the most potent analgesic activity (69.82% inhibition of writhing) followed by compounds 6e and 6g. All the synthesised compounds exhibited a potent antioxidant activity.
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Kumar
authors.forename: Archana
authors.initials: A
authors.lastname: Sharma
authors.forename: Prabodh Chander
authors.initials: PC
authors.lastname: Sharma
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005227:Fatty Acids; D053778:Thiazolidines; D006861:Hydrogen Peroxide