title: Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens.
abstract: The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulation of MDV and HVT genomes in the lungs compared to the chickens that received HVT or MDV alone. This increase in virus load was associated with augmented expression of interferon (IFN)-gamma and interleukin (IL)-10, and increased T cell infiltration. These findings shed more light on the immunological events that occur in the lungs after vaccination or infection with MDV.
authors.affiliation: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
authors.forename: Kamran
authors.initials: K
authors.lastname: Haq
authors.forename: Mohamed Faizal
authors.initials: MF
authors.lastname: Abdul-Careem
authors.forename: Sangitha
authors.initials: S
authors.lastname: Shanmuganthan
authors.forename: Niroshan
authors.initials: N
authors.lastname: Thanthrige-Don
authors.forename: Leah R
authors.initials: LR
authors.lastname: Read
authors.forename: Shayan
authors.initials: S
authors.lastname: Sharif
mesh_terms: D000818:Animals; D002645:Chickens / Q000276:immunology* / Q000821:virology; D026002:Herpesvirus 1, Meleagrid / Q000276:immunology; D008381:Herpesvirus 2, Gallid / Q000276:immunology / Q000502:physiology*; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D008168:Lung / Q000276:immunology* / Q000821:virology; D008380:Marek Disease / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D022501:Marek Disease Vaccines / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000276:immunology; D019562:Viral Load / Q000662:veterinary; D014779:Virus Replication
chemical_list: D022501:Marek Disease Vaccines; D016753:Interleukin-10; D007371:Interferon-gamma