[Functional interaction between an insulator and a Pc-dependent silencer with the example of the Mcp boundary of the Drosophila melanogaster Abd-B gene].
Insulators are cis-regulatory elements that prevent improper gene activation and heterochromatin spreading. An insulator is contained in the Mcp boundary from the regulatory region of the Drosophila melanogaster Abd-B gene. The barrier function of the Mcp insulator was studied and proved to be due to two modules. One is responsible for long-distance interactions and the capability of blocking enhancers. The other is essential for blocking Pc-dependent repression. It was observed for the first time that an insulator increased the repressor activity of a neighbor silencer.
Kyrchanova
O V
OV
Georgiev
P G
PG
D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D038101:Insulator Elements / Q000502:physiology*; D037941:Silencer Elements, Transcriptional / Q000502:physiology*
C062393:Abd-B proteins, Drosophila; D029721:Drosophila Proteins; D006570:Heterochromatin; D018398:Homeodomain Proteins