Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population.
Aspirin-intolerant asthma (AIA) occurs from asthma exacerbation after exposure to aspirin. However, the underlying mechanisms of AIA occurrence are still unclear. The critical role of the solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12 (SLC6A12) gene in GABAergic transmission, which is associated with mucus production in asthma, makes it a candidate gene for AIA association study. Eight single nucleotide polymorphisms (SNPs) in SLC6A12 were genotyped in 163 aspirin-intolerant asthma (AIA) and 429 aspirin-tolerant asthma (ATA) patients of Korean ethnicity. Associations between polymorphisms of SLC6A12 and AIA were analysed using multivariate logistic analysis. Results showed that two polymorphisms and a haplotype in SLC6A12, rs499368 (P= 0.005; P(corr)= 0.03), rs557881 (non-synonymous C10R, P= 0.007; P(corr)= 0.04), and SLC6A12_BL1_ht1 (P= 0.009; P(corr)= 0.05) respectively, were significantly associated with AIA after multiple testing corrections. In addition, SNPs of SLC6A12 were significantly associated with the fall rate of FEV(1) by aspirin provocation suggesting that SLC6A12 could affect reversibility of lung function abnormalities in AIA patients. Although these results are preliminary and future replications are needed to confirm these findings, this study showed evidence of association between variants in SLC6A12 and AIA occurrence among asthmatics in a Korean population.
Pasaje
Charisse Flerida A
CF
Department of Life Science, Sogang University, Seoul, 121-742, Republic of Korea.
Kim
Jeong-Hyun
JH
Park
Byung-Lae
BL
Cheong
Hyun Sub
HS
Chun
Ji-Yong
JY
Park
Tae-Joon
TJ
Lee
Jin-Sol
JS
Kim
Yongha
Y
Bae
Joon Seol
JS
Park
Jong Sook
JS
Yoon
Sang-Hyuk
SH
Uh
Soo-Taek
ST
Choi
Jae-Sung
JS
Kim
Yong-Hoon
YH
Kim
Mi-Kyeong
MK
Choi
Inseon S
IS
Cho
Sang Heon
SH
Choi
Byoung Whui
BW
Park
Choon-Sik
CS
Shin
Hyoung Doo
HD
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001241:Aspirin / Q000009:adverse effects / Q000276:immunology*; D001249:Asthma / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005260:Female; D050485:GABA Plasma Membrane Transport Proteins; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D002352:Carrier Proteins; D050485:GABA Plasma Membrane Transport Proteins; C072207:betaine plasma membrane transport proteins; D001241:Aspirin