The Catalytic Asymmetric Intramolecular Stetter Reaction.
This account chronicles our efforts at the development of a catalytic asymmetric Stetter reaction using chiral triazolium salts as small molecule organic catalysts. Advances in the mechanistically related azolium-catalyzed asymmetric benzoin reaction are discussed, particularly as they apply to catalyst design. A chronological treatise of reaction discovery, catalyst optimization and reactivity extension follows.
de Alaniz
Javier Read
JR
Department of Chemistry, Colorado State University, Fort Collins, Colorado.
Rovis
Tomislav
T