[Disruption of latent inhibition in adult rats after prepubertal dopamine terminals lesions in the ventral hippocampus].
Wistar rats were submitted to bilateral ventral hippocampal injection of 6-hydroxydopamine on 32nd day after birth. Latent inhibition was measured in passive or active avoidance tasks when the rats received 20 and 100 pre-exposures of conditioned stimulus. Prepubertal and adult lesioned rats showed a deficit in the latent inhibition but not in the capacity to avoidance learning in presence of the conditioned stimulus novelty. Possible mechanism of the involvement of hippocampal dopaminergic terminals in attention inhibition to irrelevant information is considered.
Loskutova
L V
LV
Kostiunina
N V
NV
Red'kina
A V
AV
D018663:Adrenergic Agents / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D007266:Inhibition, Psychological; D016627:Oxidopamine / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D018663:Adrenergic Agents; D016627:Oxidopamine