title: Biochemical T2* MR quantification of ankle arthrosis in pes cavovarus.
abstract: Pes cavovarus affects the ankle biomechanics and may lead to ankle arthrosis. Quantitative T2 STAR (T2*) magnetic resonance (MR) mapping allows high resolution of thin cartilage layers and quantitative grading of cartilage degeneration. Detection of ankle arthrosis using T2* mapping in cavovarus feet was evaluated. Eleven cavovarus patients with symptomatic ankle arthrosis (13 feet, mean age 55.6 years, group 1), 10 cavovarus patients with no or asymptomatic, mild ankle arthrosis (12 feet, mean age 41.8 years, group 2), and 11 controls without foot deformity (18 feet, mean age 29.8 years, group 3) had quantitative T2* MR mapping. Additional assessment included plain radiographs and the American Orthopaedic Foot and Ankle Society (AOFAS) score (groups 1 and 2 only). Mean global T2* relaxation time was significantly different between groups 1 and 2 (p = 0.001) and groups 1 and 3 (p = 0.017), but there was no significance for decreased global T2* values in group 2 compared to group 3 (p = 0.345). Compared to the medial compartment T2* values of the lateral compartment were significantly (p = 0.025) higher within group 1. T2* values in the medial ankle joint compartment of group 2 were significantly lower than those of group 1 (p = 0.019). Ankle arthrosis on plain radiographs and the AOFAS score correlated significantly with T2* values in the medial compartment of group 1 (p = 0.04 and 0.039, respectively). Biochemical, quantitative T2* MR mapping is likely effective to evaluate ankle arthrosis in cavovarus feet but further studies are required.
authors.affiliation: Department of Orthopaedic Surgery, Inselspital, University of Berne, Freiburgstrase, 3010 Berne, Switzerland. fabian.krause@insel.ch
authors.forename: Fabian G
authors.initials: FG
authors.lastname: Krause
authors.forename: Georg
authors.initials: G
authors.lastname: Klammer
authors.forename: Lorin M
authors.initials: LM
authors.lastname: Benneker
authors.forename: Stefan
authors.initials: S
authors.lastname: Werlen
authors.forename: Tallal C
authors.initials: TC
authors.lastname: Mamisch
authors.forename: Martin
authors.initials: M
authors.lastname: Weber
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005530:Foot Deformities / Q000503:physiopathology*; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies