title: Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology.
abstract: This proposal for standardization of (123)I-metaiodobenzylguanidine (iobenguane, MIBG) cardiac sympathetic imaging includes recommendations for patient information and preparation, radiopharmaceutical, injected activities and dosimetry, image acquisition, quality control, reconstruction methods, attenuation, scatter and collimator response compensation, data analysis and interpretation, reports, and image display. The recommendations are based on evidence coming from original or scientific studies whenever possible and as far as possible reflect the current state-of-the-art in cardiac MIBG imaging. The recommendations are designed to assist in the practice of performing, interpreting and reporting cardiac sympathetic imaging. The proposed standardization does not include clinical indications, benefits or drawbacks of cardiac sympathetic imaging, and does not address cost benefits or cost effectiveness; however, clinical settings of potential utility are mentioned. Standardization of MIBG cardiac sympathetic imaging should contribute to increasing its clinical applicability and integration into current nuclear cardiology practice.
authors.affiliation: Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. aflotats@santpau.cat
authors.forename: Albert
authors.initials: A
authors.lastname: Flotats
authors.forename: Ignasi
authors.initials: I
authors.lastname: Carrió
authors.forename: Denis
authors.initials: D
authors.lastname: Agostini
authors.forename: Dominique
authors.initials: D
authors.lastname: Le Guludec
authors.forename: Claudio
authors.initials: C
authors.lastname: Marcassa
authors.forename: Michael
authors.initials: M
authors.lastname: Schäfers
authors.forename: Michael
authors.initials: M
authors.lastname: Schaffers
authors.forename: G Aernout
authors.initials: GA
authors.lastname: Somsen
authors.forename: Mustafa
authors.initials: M
authors.lastname: Unlu
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Verberne
mesh_terms: D019797:3-Iodobenzylguanidine / Q000008:administration & dosage / Q000009:adverse effects; D002309:Cardiology / Q000379:methods / Q000592:standards*; D000075202:Contraindications; D003952:Diagnostic Imaging / Q000379:methods / Q000592:standards*; D004781:Environmental Exposure; D005060:Europe; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D009683:Nuclear Medicine / Q000379:methods / Q000592:standards*; D011786:Quality Control; D011874:Radiometry; D012107:Research Design; D012542:Scattering, Radiation; D013223:Statistics as Topic; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019797:3-Iodobenzylguanidine