title: Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men.
abstract: Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index-adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index-adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Nakata
authors.forename: Jina
authors.initials: J
authors.lastname: Choo
authors.forename: Michael J S
authors.initials: MJ
authors.lastname: Hopson
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.forename: J David
authors.initials: JD
authors.lastname: Curb
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
authors.forename: Rhobert W
authors.initials: RW
authors.lastname: Evans
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Teruo
authors.initials: T
authors.lastname: Otake
authors.forename: Aya
authors.initials: A
authors.lastname: Kadota
authors.forename: Syaka
authors.initials: S
authors.lastname: Kadowaki
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.forename: Aiman
authors.initials: A
authors.lastname: El-Saed
authors.forename: Daniel
authors.initials: D
authors.lastname: Edmundowicz
authors.forename: Kim
authors.initials: K
authors.lastname: Sutton-Tyrrell
authors.forename: Lewis H
authors.initials: LH
authors.lastname: Kuller
authors.forename: Akira
authors.initials: A
authors.lastname: Sekikawa
mesh_terms: D000005:Abdomen; D000328:Adult; D015992:Body Mass Index; D006801:Humans; D007564:Japan; D008074:Lipoproteins / Q000097:blood / Q000145:classification; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014481:United States; D055105:Waist Circumference; D044465:White People
chemical_list: D008074:Lipoproteins