title: [Postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery].
abstract: OBJECTIVE
  To investigate the postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery.
  
  
  METHODS
  Eighty patients undergoing posterior spinal surgery under general anesthesia were randomly divided into parecoxib sodium group and placebo group (n=40). All the patients received a single dose of m ml morphine (1.0 mg/ml) as the background analgesia immediately after the operation. The patients in parecoxib sodium group were given 40 mg parecoxib sodium intravenously, and those in the placebo group received an equivalent volume of saline instead, and at 24 and 48 h after the operation, the same dose was repeated. The visual analog pain score, patient satisfaction and adverse reactions were recorded after the administrations.
  
  
  RESULTS
  Compared with the placebo group, the patients in parecoxib sodium group had significantly lowered VAS score at 6, 12, 24, and 48 h after the operation (P<0.05). No significant differences were noted in the patient satisfaction and adverse reactions between the two groups.
  
  
  CONCLUSIONS
  Postoperative short-term use of parecoxib sodium can can provide good postoperative analgesic effect in patients undergoing posterior spinal surgery.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. caimingxue6666@126.com
authors.forename: Ming-xue
authors.initials: MX
authors.lastname: Cai
authors.forename: Ya-lan
authors.initials: YL
authors.lastname: Li
authors.forename: Hong-sheng
authors.initials: HS
authors.lastname: Lin
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Peng
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000768:Anesthesia, General; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D013122:Spinal Diseases / Q000601:surgery*
chemical_list: D018712:Analgesics, Non-Narcotic; D052246:Cyclooxygenase 2 Inhibitors; D007555:Isoxazoles; C409945:parecoxib