RETRACTED: Genetic signatures of exceptional longevity in humans.
Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls. Using these data, we built a genetic model that includes 150 single-nucleotide polymorphisms (SNPs) and found that it could predict EL with 77% accuracy in an independent set of centenarians and controls. Further in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characterized by different combinations of SNP genotypes-or genetic signatures-of varying predictive value. The different signatures, which attest to the genetic complexity of EL, correlated with differences in the prevalence and age of onset of age-associated diseases (e.g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging.
Sebastiani
Paola
P
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. sebas@bu.edu
Solovieff
Nadia
N
Puca
Annibale
A
Hartley
Stephen W
SW
Melista
Efthymia
E
Andersen
Stacy
S
Dworkis
Daniel A
DA
Wilk
Jemma B
JB
Myers
Richard H
RH
Steinberg
Martin H
MH
Montano
Monty
M
Baldwin
Clinton T
CT
Perls
Thomas T
TT