microRNA-181b targets MLK2 in HL-60 cells.
microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
Chen
Hong
H
The First Affiliated Hospital of Harbin Medical University, Harbin, 150101, China.
Chen
Qun
Q
Harbin Acheng District People's Hospital, Harbin, 150300, China.
Fang
Ming
M
Graduate department of Harbin Medical University, Harbin, 150001, China.
Mi
Yan
Y
The First Affiliated Hospital of Harbin Medical University, Harbin, 150101, China. miyanok@126.com.
D001483:Base Sequence; D015153:Blotting, Western; D049109:Cell Proliferation; D002470:Cell Survival; D015973:Gene Expression Regulation, Leukemic; D018922:HL-60 Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020930:MAP Kinase Kinase Kinases / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection
C540193:MIrn181 microRNA, human; D035683:MicroRNAs; D020930:MAP Kinase Kinase Kinases; C093290:MAP3K10 protein, human