title: Predictors of acute decompensation after admission in ED patients with sepsis.
abstract: OBJECTIVE
  The aim of the study was to identify predictors of acute decompensation within 48 hours of admission among infected emergency department (ED) patients admitted to a regular nursing floor.
  
  
  METHODS
  This used a case control study of infected ED patients admitted to a regular nursing floor and who received a discharge diagnosis of sepsis. A multivariate logistic regression model was constructed with the dependent variable as transfer to an intensive care unit (ICU) within 48 hours of admission.
  
  
  RESULTS
  Seventy-eight patients were enrolled-34 in the ICU group and 44 in the floor group. Only low bicarbonate (<20 mmol/L) (odds ratio [OR], 7.40; 95% confidence interval [CI], 2.35-23.30) and absence of fever (OR, 3.66; 95% CI, 1.11-12.60) were predictive of ICU transfer.
  
  
  CONCLUSIONS
  Among infected ED patients admitted to a regular floor, absence of fever and low bicarbonate were independently associated with ICU transfer within 48 hours. Particular attention should be paid to similar patients to ensure appropriate identification of severe infection and appropriate risk stratification.
authors.affiliation: Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA. jeffrey.caterino@osumc.edu
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Caterino
authors.forename: Tracy
authors.initials: T
authors.lastname: Jalbuena
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bogucki
mesh_terms: D016022:Case-Control Studies; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011237:Predictive Value of Tests; D012307:Risk Factors; D018805:Sepsis / Q000150:complications*; D012772:Shock, Septic