title: Congenital syphilis: refining newborn evaluation and management in Shenzhen, southern China.
abstract: BACKGROUND
  Consistent definitions of congenital syphilis are critical for determining true incidences and setting up targets of elimination. This study aimed to assess the evaluation and management of infants at high risk of congenital syphilis with an antenatal syphilis-screening programme in the Shenzhen SEZ and to develop feasible definitions for the detection of congenital syphilis in China.
  
  
  METHODS
  A retrospective study was conducted of all standardised records of pregnant women with positive syphilis between 2003 and 2007. Infants at high risk of congenital syphilis were evaluated by laboratory tests at birth and longitudinal follow-up. A screening test-positive congenital syphilis case was defined based on a positive 19S-IgM-FTA-ABS result at birth. Assuming that 19S-IgM-FTA-ABS was the gold standard, the sensitivity and specificity of the ascertainment methods were calculated.
  
  
  RESULTS
  During the study period, 1010 live infants were born to women with active syphilis during pregnancy. 19S-IgM-FTA-ABS detected 42 screening-positive congenital syphilis cases and another nine cases were identified by longitudinal follow-up only. Using 19S-IgM-FTA-ABS as the gold standard, 'fourfold rapid plasma reagin (RPR) titres' had the highest sensitivity and specificity compared with the other two follow-up methods.
  
  
  CONCLUSIONS
  19S-IgM-FTA-ABS makes congenital syphilis case classification simpler and faster for newborns. In areas where 19S-IgM-FTA-ABS is not available, comparing newborn RPR titres with maternal titres can be an alternative method. Meanwhile, positive follow-up results act as treatment indicators for older infants. As congenital syphilis definitions vary over the country, the Shenzhen programme suggested a practical model for surveillance and treatment in areas with or without available 19S-IgM-FTA-ABS testing.
authors.affiliation: Shenzhen Center for Chronic Disease Control, 2021 Buxin Road, Luohu District, Shenzhen 518053, China.
authors.forename: Da-Dong
authors.initials: DD
authors.lastname: Wu
authors.forename: Fu-Chang
authors.initials: FC
authors.lastname: Hong
authors.forename: Tie-Jian
authors.initials: TJ
authors.lastname: Feng
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Liu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Lin
authors.forename: Li-Shan
authors.initials: LS
authors.lastname: Tian
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Qiu
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D015997:Neonatal Screening / Q000379:methods; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control; D011296:Prenatal Diagnosis / Q000379:methods; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013588:Syphilis Serodiagnosis / Q000379:methods; D013590:Syphilis, Congenital / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy