title: Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction.
abstract: To better understand the contribution of the fat mass to the effects of long-term caloric restriction in humans, we compared adipokine profile and insulin sensitivity in long-term calorically restricted formerly obese women (CRW) subjected to different interventions, bariatric surgery, or reducing diet, with age- and BMI-matched obese (OW) and normal-weight women (NW) eating ad libitum. Our key findings are that despite a considerably stronger weight loss induced by bariatric surgery, both long-term caloric restriction interventions improved insulin sensitivity to the same degree and led to significantly lower retinol-binding protein-4 and interleukin-6 serum levels than in OW, suggesting that lowering of these two adipokines contributes to the improved insulin sensitivity. Moreover, serum leptin was considerably lower in CRW than in OW as well as in NW, suggesting that CRW develop hypoleptinemia.
authors.affiliation: Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Mitterberger
authors.forename: Monika
authors.initials: M
authors.lastname: Mattesich
authors.forename: Elise
authors.initials: E
authors.lastname: Klaver
authors.forename: Stefan
authors.initials: S
authors.lastname: Lechner
authors.forename: Timm
authors.initials: T
authors.lastname: Engelhardt
authors.forename: Lorenz
authors.initials: L
authors.lastname: Larcher
authors.forename: Gerhard
authors.initials: G
authors.lastname: Pierer
authors.forename: Hildegunde
authors.initials: H
authors.lastname: Piza-Katzer
authors.forename: Werner
authors.initials: W
authors.lastname: Zwerschke
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D031204:Caloric Restriction; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000628:therapy; D052243:Resistin / Q000097:blood; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D014284:Triiodothyronine / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; C101326:RBP4 protein, human; D052243:Resistin; D054839:Retinol-Binding Proteins, Plasma; D014409:Tumor Necrosis Factor-alpha; D014284:Triiodothyronine; D054409:Nicotinamide Phosphoribosyltransferase