title: Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.
abstract: We report herein the structure-based design of a class of conformationally constrained, potent, cell-permeable small-molecule inhibitors to target the SH2 domain in STAT3. Compound 11 (CJ-1383) binds to STAT3 with a K(i) value of 0.95 µM, dose-dependently inhibits cellular STAT3 signaling and cancer cell growth, and induces apoptosis in the MDA-MB-468 cancer cell line with constitutively activated STAT3.
authors.affiliation: Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Chen
authors.forename: Longchuan
authors.initials: L
authors.lastname: Bai
authors.forename: Denzil
authors.initials: D
authors.lastname: Bernard
authors.forename: Zaneta
authors.initials: Z
authors.lastname: Nikolovska-Coleska
authors.forename: Cindy
authors.initials: C
authors.lastname: Gomez
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Yi
authors.forename: Shaomeng
authors.initials: S
authors.lastname: Wang