title: Room-temperature synthesis of enantioenriched non-protected cyanohydrins using vanadium(salalen) catalyst.
abstract: Room-temperature synthesis of enantioenriched non-protected cyanohydrins using acetone cyanohydrin as the cyanide source was achieved by V(salalen) catalyst. Aliphatic aldehydes underwent the cyanation with 89-95% ee in the presence of only 0.2-0.4 mol% catalyst. Aromatic cyanohydrins were also obtained in high enantiomeric excesses under modified conditions.
authors.affiliation: Department of Chemistry, Faculty of Science, Graduate School, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sakai
authors.forename: Junko
authors.initials: J
authors.lastname: Mitote
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Katsuki