Isolation and anti-inflammatory activity evaluation of triterpenoids and a monoterpenoid glycoside from Harpagophytum procumbens.
A new triterpenoid glycoside, designated harproside (1), and a new iridoid glycoside, named pagide (2), along with six known triterpenoids (3-8), were obtained from the tubers of Harpagophytum procumbens D. C. (devil's claw), and their structures were established through chemical methods and spectroscopic analyses. In an in vitro assay, the six triterpenoids showed anti-inflammatory activity. Compounds 3, 7, and 8 showed significant inhibitory activity against neutrophil respiratory burst stimulated by PMA, while compounds 4, 5, and 6 showed marginal inhibitory activity.
Qi
Jin
J
Key Laboratory of Modern TCM Department of Pharmacognosy, China Pharmaceutical University, Nanjing, P R China.
Li
Na
N
Zhou
Jia-Hong
JH
Yu
Bo-Yang
BY
Qiu
Samuel X
SX
D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031684:Harpagophytum / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035281:Plant Tubers; D016897:Respiratory Burst / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D006027:Glycosides; D039823:Iridoids; D010936:Plant Extracts; D014315:Triterpenes; C557810:harproside; C557809:pagide