Historic perspectives on Annonaceous acetogenins from the chemical bench to preclinical trials.
Studies on the Annonaceous acetogenins began after the first cytotoxic acetogenin, uvaricin, was isolated in 1982. This attractive finding made many medicinal and natural product chemists direct their efforts on the isolation and identification of these classes of compounds. As more Annonaceous acetogenins were isolated, more information about them was uncovered. From their structural identification to the total synthesis of natural product analogues and from cell-based screening and molecular-based targeting to animal testing, the mechanisms of action of the Annonaceous acetogenins became clearer. The purpose of this review is to give an account of recent studies on this class of compounds and their analogues, which will aid us not only in clarifying how the Annonaceous acetogenins act but also in establishing principles for the further development of this class of compounds.
Liaw
Chih-Chuang
CC
Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung, Taiwan.
Wu
Tung-Ying
TY
Chang
Fang-Rong
FR
Wu
Yang-Chang
YC
D054378:Acetogenins / Q000737:chemistry* / Q000266:history / Q000494:pharmacology*; D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D049673:History, 20th Century; D006801:Humans; D015394:Molecular Structure; D008517:Phytotherapy / Q000266:history; D010936:Plant Extracts / Q000737:chemistry* / Q000266:history / Q000494:pharmacology*
D054378:Acetogenins; D010936:Plant Extracts