title: Lymphocytic hypophysitis with diabetes insipidus in a young man.
abstract: BACKGROUND
  A 29-year-old man was referred to a multidisciplinary pituitary clinic with a 3.5-year history of central diabetes insipidus, initially presumed to be idiopathic based on a normal MRI scan of the pituitary gland. Subsequent scanning revealed a suprasellar mass, which demonstrated progressive enlargement on serial imaging. He also developed hypogonadotropic hypogonadism.
  
  
  METHODS
  Measurement of levels of serum morning fasting cortisol, adrenocorticotropic hormone, total testosterone, luteinizing hormone, follicle-stimulating hormone, prolactin, insulin-like growth factor 1, TSH and free T(4), MRI of the pituitary gland and a transsphenoidal biopsy of a pituitary mass were performed.
  
  
  METHODS
  Lymphocytic hypophysitis presenting with diabetes insipidus, with development of hypogonadotropic hypogonadism and a suprasellar mass.
  
  
  RESULTS
  The patient was treated with intranasal desmopressin and transdermal testosterone. The underlying lymphocytic hypophysitis was initially managed conservatively with serial MRI and visual field testing. No immunosuppressant medication was given and, aside from the diagnostic transsphenoidal biopsy, no surgical intervention was required. He subsequently developed secondary hypothyroidism, secondary adrenal insufficiency and growth hormone deficiency. These disorders were managed with levothyroxine and prednisone.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Ole-Petter R
authors.initials: OP
authors.lastname: Hamnvik
authors.forename: Anna R
authors.initials: AR
authors.lastname: Laury
authors.forename: Edward R
authors.initials: ER
authors.lastname: Laws
authors.forename: Ursula B
authors.initials: UB
authors.lastname: Kaiser
mesh_terms: D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000175:diagnosis; D008297:Male; D010900:Pituitary Diseases / Q000097:blood / Q000175:diagnosis*; D013739:Testosterone / Q000627:therapeutic use
chemical_list: D013739:Testosterone; D003894:Deamino Arginine Vasopressin