The role of oxidative stress and anti-oxidant treatment in platinum-induced peripheral neurotoxicity.
Platinum-based anticancer drugs are a cornerstone of the current antineoplastic treatment. However, their use is limited by the onset of peripheral nervous system dysfunction, which can be severe and persistent over a long period of time. Among the several hypothesis proposed to explain this side effect, evidence is increasing that dorsal root ganglia (DRG) oxidative stress can be an important pathogenetic mechanism and, possibly, a therapeutic target to limit the severity of platinum-induced peripheral neurotoxicity but preserving the anticancer effectiveness. In fact, DRG energy failure has been suggested as a result of mitochondrial DNA-platinum binding and several antioxidant drugs have been tested in pre-clinical experiments and clinical trials. In this review, an update on the current knowledge on the relationship existing between oxidative stress and platinum drugs peripheral neurotoxicity will be given.
Carozzi
V A
VA
Department of Neurosciences and Biomedical Technologies, University of Milano-Bicocca, Monza (MI), Italy. valentina.carozzi1@unimib.it
Marmiroli
P
P
Cavaletti
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D000975:Antioxidants / Q000627:therapeutic use*; D016190:Carboplatin / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D018384:Oxidative Stress / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D017671:Platinum Compounds / Q000009:adverse effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D018696:Neuroprotective Agents; D009944:Organoplatinum Compounds; D017671:Platinum Compounds; D017382:Reactive Oxygen Species; D000077150:Oxaliplatin; D016190:Carboplatin; D002945:Cisplatin