Poly(β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells.
A novel PCD/CUR self-assembly approach for improved curcumin delivery to prostate cancer cells is described. The formation of PCD/CUR was confirmed using FTIR, DSC, TGA, and SEM/TEM, and their stability and solubility under physiological conditions was demonstrated. A mechanism for self-assembly is proposed. Intracellular uptake of the self-assemblies was studied by flow cytometry and immunofluorescence microscopy. The therapeutic efficacy was determined by cell proliferation and colony formation assays using C4-2, DU145 and PC3 prostate cancer cells. The results suggest that the PCD/CUR formulation could be a useful system for improving curcumin delivery and its therapeutic efficacy in prostate cancer.
Yallapu
Murali Mohan
MM
Cancer Biology Research Center, Sanford Research/USD, 1400 W. 22nd Street, Sioux Falls, SD 57105, USA.
Jaggi
Meena
M
Chauhan
Subhash C
SC
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D008297:Male; D008958:Models, Molecular; D011409:Propylene Glycols / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011409:Propylene Glycols; D047392:beta-Cyclodextrins; C507884:poly(beta-cyclodextrin); D003474:Curcumin