title: Reduction of free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion.
abstract: In this work we investigated the acute effects of hemodiafiltration with endogenous reinfusion (HFR therapy) on the removal of free immunoglobulin light chains (FIgLCs), which may be considered members of the family of uremic toxins. In two groups of patients - group 1 (polyclonal FIgLCs production) and group 2 (monoclonal plasma cell proliferative disorders), we analyzed the pre- and postdialysis levels of kappa- and lambda-chains. In group 1 we observed a significant reduction of FIgLCs (p < 0.01). A similar trend was found in patients of group 2 only for kappa-chains. The FIgLCs removal ratio was significantly higher for kappa- than lambda-chains in the two patient groups. In vitro data showed affinity of macroporous resin to binding FIgLCs. Our results show that the HFR therapy could be effective in removing FIgLCs, particularly kappa-chains in dialysis patients with polyclonal and monoclonal FIgLCs production.
authors.affiliation: Expansion Centres d'Hémodialyse de l'Ouest, Nantes, France. atesta@echo-sante.com
authors.forename: Angelo
authors.initials: A
authors.lastname: Testa
authors.forename: Thomas
authors.initials: T
authors.lastname: Dejoie
authors.forename: Didier
authors.initials: D
authors.lastname: Lecarrer
authors.forename: Marylou
authors.initials: M
authors.lastname: Wratten
authors.forename: Luisa
authors.initials: L
authors.lastname: Sereni
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Renaux
mesh_terms: D000327:Adsorption; D017583:Hemodiafiltration / Q000379:methods*; D015312:Hemodialysis Solutions / Q000008:administration & dosage*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D013499:Surface Properties; D014511:Uremia / Q000097:blood / Q000628:therapy*
chemical_list: D015312:Hemodialysis Solutions; D007147:Immunoglobulin Light Chains