title: Experimental evaluation of acute molding of the regenerate in mandibular distraction osteogenesis in a rabbit model.
abstract: OBJECTIVE
  The aim of this study was to investigate the possible effect of acute regenerate molding (ARM) on bone healing in mandibular distraction osteogenesis (DO).
  
  
  METHODS
  Nine white New Zealand rabbits underwent unilateral mandibular lengthening via DO. Three groups were created: The first underwent 15° ARM, the second group underwent 30° ARM after the distraction period, and the third group served as control without molding. After 1 month of consolidation, all of the animals were killed and histomorphometric evaluation was performed.
  
  
  RESULTS
  New bone formation was uneventful in all of the groups. In the ARM groups, the amounts of osteoblasts and newly formed bone areas were higher in compressed areas than in stretched ones (P < .05). The regenerates in the control group and stretched regenerate areas of the ARM groups were similar regarding new bone formation (P > .05).
  
  
  CONCLUSIONS
  Acute regenerate molding could be safely applied immediately after the distraction period to correct postdistraction deformities without compromising bone healing.
authors.affiliation: Consultant, Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Celal
authors.initials: C
authors.lastname: Candırlı
authors.forename: Doğan
authors.initials: D
authors.lastname: Dolanmaz
authors.forename: Osman A
authors.initials: OA
authors.lastname: Etöz
authors.forename: Mustafa Cihat
authors.initials: MC
authors.lastname: Avunduk
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000502:physiology*; D002356:Cartilage / Q000473:pathology; D003094:Collagen; D004867:Equipment Design; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D023421:Models, Animal; D010006:Osteoblasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D010027:Osteotomy / Q000379:methods; D011817:Rabbits; D011897:Random Allocation; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D003094:Collagen