title: Low maternal PAPP-A is associated with small-for-gestational age newborns and stillbirths.
abstract: We investigated the association of first trimester low maternal serum pregnancy-associated plasma protein-A (PAPP-A) levels with small-for-gestational age (SGA) newborns and stillbirths (SBs) in a retrospective national population-based register study. The study group comprised 921 women with the lowest 5% PAPP-A levels (< or =0.3 MoM) and the control group comprising 18,615 women with PAPP-A levels >0.3 MoM. In the study group there were 35 (3.8%) and in the control group 213 SGA newborns (1.1%), respectively (OR, 3.41; 95% CI, 2.37-4.91). There were 9 (1.0%) and 51 (0.3%) cases of SBs in the study and control groups, respectively (p < 0.002; OR, 3.59; 95% CI, 1.76-7.32). Low PAPP-A is a risk factor for SGA and SB.
authors.affiliation: Department of Obstetrics & Gynecology, Oulu University Hospital, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Marttala
authors.forename: Sini
authors.initials: S
authors.lastname: Peuhkurinen
authors.forename: Paivi
authors.initials: P
authors.lastname: Laitinen
authors.forename: Mika
authors.initials: M
authors.lastname: Gissler
authors.forename: Pentti
authors.initials: P
authors.lastname: Nieminen
authors.forename: Markku
authors.initials: M
authors.lastname: Ryynanen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D012042:Registries; D012189:Retrospective Studies; D050497:Stillbirth
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A