title: The HPV vaccination strategy: could male vaccination have a significant impact?
abstract: We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, Re0, which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. We study the effects of different parameters on both of these quantities. Results show that waning immunity plays a large part in allowing infection to persist. The proportion of the population not sexually active when vaccination occurs affects Re0, as does the rate at which individuals become sexually active. In several cases, infection persists as a result of an infection reservoir in the male cohort. To explore this further, we introduce male vaccination and find the conditions for which vaccination of males could be considered appropriate.
authors.affiliation: Centre for Mathematical Biology, University of Bath, Bath, UK. v.l.brown@bath.ac.uk
authors.forename: V
authors.initials: V
authors.lastname: Brown
authors.forename: K A J
authors.initials: KA
authors.lastname: White
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D027383:Papillomaviridae / Q000276:immunology; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines / Q000276:immunology / Q000627:therapeutic use*; D015995:Prevalence; D012725:Sexual Behavior / Q000706:statistics & numerical data; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination / Q000379:methods*
chemical_list: D053918:Papillomavirus Vaccines