Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
Prostate cancer is a major cause of mortality, largely as a consequence of metastases and transformation to androgen-independent growth. Metalloproteinases are implicated in cancer progression. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are expressed in prostate cancer cells, with ADAMTS-1 and ADAMTS-15 being the most abundant. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene. ADAMTS-15 expression is predictive for survival in breast cancer, and the situation may be similar in prostate cancer, as androgen independence is usually due to aberrant signaling through its receptor.
Molokwu
Chidi N
CN
University of Sheffield Medical School, United Kingdom.
Adeniji
Olajumoke O
OO
Chandrasekharan
Shankar
S
Hamdy
Freddie C
FC
Buttle
David J
DJ
D051722:ADAM Proteins / Q000235:genetics*; D000071096:ADAMTS Proteins; D000071097:ADAMTS1 Protein; D000728:Androgens / Q000502:physiology*; D000818:Animals; D045744:Cell Line, Tumor; D013196:Dihydrotestosterone / Q000494:pharmacology*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000235:genetics
D000728:Androgens; D013196:Dihydrotestosterone; D051722:ADAM Proteins; D000071096:ADAMTS Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human; C500267:ADAMTS15 protein, human