title: Luteal phase progesterone increases live birth rate after frozen embryo transfer.
abstract: OBJECTIVE
  To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles.
  
  
  METHODS
  Prospective randomized controlled trial.
  
  
  METHODS
  University-based hospital.
  
  
  METHODS
  Four hundred thirty-five women undergoing embryo transfer in natural cycles.
  
  
  METHODS
  The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support.
  
  
  METHODS
  Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate.
  
  
  RESULTS
  Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate.
  
  
  CONCLUSIONS
  Progesterone supplementation improves live birth rate after embryo transfer in natural cycles.
authors.affiliation: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Bjuresten
authors.forename: Britt-Marie
authors.initials: BM
authors.lastname: Landgren
authors.forename: Outi
authors.initials: O
authors.lastname: Hovatta
authors.forename: Anneli
authors.initials: A
authors.lastname: Stavreus-Evers
mesh_terms: D000328:Adult; D000465:Algorithms; D004334:Drug Administration Schedule; D004624:Embryo Transfer / Q000379:methods* / Q000706:statistics & numerical data; D004622:Embryo, Mammalian; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology; D005615:Freezing; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D008183:Luteal Phase / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D005300:Fertility Agents, Female; D011374:Progesterone