title: Diabetes, physical activity and breast cancer among Hispanic women.
abstract: OBJECTIVE
  We assessed the association between diabetes and breast cancer and whether physical activity modified the effect of diabetes on breast cancer in Hispanic women.
  
  
  METHODS
  We used data from a case-control study of breast cancer among Hispanic women aged 30-79 conducted between 2003 and 2008 on the Texas-Mexico border. In-person interviews were completed with 190 incident breast cancer cases ascertained through surgeons and oncologists, and 979 controls who were designated as both high-risk (n=511) and low-risk (N=468) for breast cancer (with respective response rates of 97%, 83% and 74%).
  
  
  RESULTS
  After adjustment for menopausal status and mammography screening, there was no effect of diabetes on breast cancer risk (high-risk control group odds ratio [OR] 1.02, 95% confidence interval [CI] 0.71-1.48; low-risk control group OR 0.87, 0.58-1.30). Women who had a diabetes history and did not exercise were at no risk of breast cancer (OR 0.96, 95% CI 0.63-1.48) or a slightly reduced breast cancer risk (low-risk control group OR 0.72, 95% CI 0.46-1.15) depending on the control group used, while women with diabetes who did exercise had significantly reduced breast cancer risk (OR 0.41, 95% CI 0.21-0.83) regardless of the control group used (high-risk control group p-value for interaction=0.013, low-risk control group p-value for interaction 0.183).
  
  
  CONCLUSIONS
  Should other studies confirm our results, physical activity should be explored as a means of reducing breast cancer risk in diabetic women.
authors.affiliation: Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, TN 37208, USA. msanderson@mmc.edu
authors.forename: Maureen
authors.initials: M
authors.lastname: Sanderson
authors.forename: Gerson
authors.initials: G
authors.lastname: Peltz
authors.forename: Adriana
authors.initials: A
authors.lastname: Perez
authors.forename: Matthew
authors.initials: M
authors.lastname: Johnson
authors.forename: Sally W
authors.initials: SW
authors.lastname: Vernon
authors.forename: Maria E
authors.initials: ME
authors.lastname: Fernandez
authors.forename: Mary K
authors.initials: MK
authors.lastname: Fadden
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000208:ethnology*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000208:ethnology*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009043:Motor Activity; D012307:Risk Factors; D013781:Texas / Q000453:epidemiology