title: Homo- and heptanor-sterols and tremulane sesquiterpenes from cultures of Phellinus igniarius.
abstract: Four steroids, a homopregnene (1) and three heptanorergosterane derivatives (2-4), nine tremulane sesquiterpenes (5-13), and 18 known compounds have been isolated from cultures of the fungus Phellinus igniarius. Their structures and absolute configurations were elucidated by spectroscopic data analysis. In preliminary in vitro assays, at 10(-5) M, compounds 8, 9, 13, and 3beta-hydroxy-11,12-O-isopropyldrimene (14) showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 35.7%, 45.4%, 46.6%, and 32.1%, respectively, as compared with the blank control.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, People's Republic of China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Chenggen
authors.initials: C
authors.lastname: Zhu
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Yue
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Jungui
authors.initials: J
authors.lastname: Dai
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010656:Phenylephrine / Q000494:pharmacology; D011124:Polyporaceae / Q000737:chemistry*; D011283:Pregnenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C551553:3,17,20-trihydroxy-4-methylpregn-8-en-7-one; D011283:Pregnenes; D012717:Sesquiterpenes; D013261:Sterols; D014665:Vasodilator Agents; C551554:phellinignincisterol A; C551556:phellinignincisterol B; C551555:phellinignincisterol C; D010656:Phenylephrine