title: Rab6 and myosin II at the cutting edge of membrane fission.
abstract: Rab GTPases regulate the dynamics of transport carriers by participating in their translocation across the cytoplasm, and in their docking and fusion with acceptor compartments. An interaction between Golgi-associated Rab6 and myosin II has now been shown to regulate the fission of Rab6-positive carriers, illuminating a previously unappreciated role for Rab6 and the actomyosin system in carrier biogenesis.
authors.forename: Carmen
authors.initials: C
authors.lastname: Valente
authors.forename: Roman
authors.initials: R
authors.lastname: Polishchuk
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: De Matteis
mesh_terms: D000199:Actins / Q000378:metabolism; D000205:Actomyosin / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008954:Models, Biological; D024462:Myosin Type II / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D000199:Actins; C094135:Rab6 protein; D000205:Actomyosin; D024462:Myosin Type II; D020691:rab GTP-Binding Proteins