title: A new antitumour ansamitocin from Actinosynnema pretiosum.
abstract: A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.
authors.forename: Guo-Zhu
authors.initials: GZ
authors.lastname: Wei
authors.forename: Lin-Quan
authors.initials: LQ
authors.lastname: Bai
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Zeng
authors.forename: Yue-Mao
authors.initials: YM
authors.lastname: Shen
authors.forename: Pei-Ji
authors.initials: PJ
authors.lastname: Zhao
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008453:Maytansine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D008453:Maytansine; C015682:ansamitocins