Evidences of osteoporosis improvement in Wistar rats treated with Ginkgo biloba extract: a histomorphometric study of mandible and femur.
This study was aimed at investigating the anti-osteoporotic effects of the extract of Ginkgo biloba (EGb) in glucocorticoid-induced-osteoporosis. A significant reduction was observed in the percentage of the bone of the osteoporosis group in both the mandible and femur. The EGb group treated with 28 and 56 mg/Kg showed a significant increase in the percentage of trabecular bone (PTB) of the femur. The percentage of the alveolar bone of the mandible (PAB) had a significant increase with all doses of EGb. The treatment with EGb significantly reversed the loss of the PAB of the mandible and of the PTB of the femur.
Lucinda
L M F
LM
Centro de Biologia da Reprodução, Federal University of Juiz de Fora, Caixa Postal 328, Zip Code 36001-970 Juiz de Fora, MG, Brazil. ledamarilia@yahoo.com.br
Vieira
B J
BJ
Oliveira
T T
TT
Sá
R C S
RC
Peters
V M
VM
Reis
J E P
JE
Guerra
M O
MO
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D003907:Dexamethasone / Q000031:analogs & derivatives / Q000633:toxicity; D005260:Female; D005269:Femur; D020441:Ginkgo biloba / Q000737:chemistry*; D008334:Mandible; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone