Congenital Langerhans cell histiocytosis with skin and lung involvement: spontaneous regression.
Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo spontaneous regression. Systemic signs are generally absent. We describe a 4-month-old infant presenting with reddish brown nodular cutaneous lesions since birth with a past history suggestive of pulmonary involvement. Skin biopsy showed a dermal infiltrate of pleomorphic histiocytes; which were CD1a and S-100 positive, consistent with the diagnosis of CSHLCH. Both pulmonary and cutaneous lesions showed spontaneous resolution.
Aggarwal
Varun
V
Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India.
Seth
Anju
A
Jain
Manjula
M
Krishnamurthy
Sriram
S
Chandra
Varkha
V
Aneja
Satinder
S
D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000151:congenital* / Q000473:pathology; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D007223:Infant; D008297:Male; D012075:Remission, Spontaneous; D012120:Respiration Disorders / Q000209:etiology*; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology