title: Detection of quantitative trait loci affecting haematological traits in swine via genome scanning.
abstract: BACKGROUND
  Haematological traits, which consist of mainly three components: leukocyte traits, erythrocyte traits and platelet traits, play extremely important role in animal immune function and disease resistance. But knowledge of the genetic background controlling variability of these traits is very limited, especially in swine.
  
  
  RESULTS
  In the present study, 18 haematological traits (7 leukocyte traits, 7 erythrocyte traits and 4 platelet traits) were measured in a pig resource population consisting of 368 purebred piglets of three breeds (Landrace, Large White and Songliao Black Pig), after inoculation with the swine fever vaccine when the pigs were 21 days old. A whole-genome scan of QTL for these traits was performed using 206 microsatellite markers covering all 18 autosomes and the X chromosome. Using variance component analysis based on a linear mixed model and the false discovery rate (FDR) test, 35 QTL with FDR < 0.10 were identified: 3 for the leukocyte traits, 28 for the erythrocyte traits, and 4 for the platelet traits. Of the 35 QTL, 25 were significant at FDR < 0.05 level, including 9 significant at FDR < 0.01 level.
  
  
  CONCLUSIONS
  Very few QTL were previously identified for hematological traits of pigs and never in purebred populations. Most of the QTL detected here, in particular the QTL for the platelet traits, have not been reported before. Our results lay important foundation for identifying the causal genes underlying the hematological trait variations in pigs.
authors.affiliation: Key Laboratory Animal Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
authors.forename: Yuan-Fang
authors.initials: YF
authors.lastname: Gong
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Hu
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Luo
authors.forename: Shao-Qian
authors.initials: SQ
authors.lastname: Cai
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Qi
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Niu
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Qiu
authors.forename: Jian
authors.initials: J
authors.lastname: Zeng
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001773:Blood Cells; D001792:Blood Platelets; D001947:Breeding; D004912:Erythrocytes; D007113:Immunity, Innate / Q000235:genetics*; D007962:Leukocytes; D040641:Quantitative Trait Loci; D013312:Stress, Physiological / Q000235:genetics; D034421:Sus scrofa / Q000235:genetics* / Q000276:immunology*