title: Characterization of two anti-fungal lipopeptides produced by Bacillus amyloliquefaciens SH-B10.
abstract: Bacillus amyloliquefaciens SH-B10 isolated from deep-sea sediment produces two anti-fungal lipopeptides that were purified by bioactivity-guided fractionation based on acid precipitation, vacuum flash chromatography and semi-preparative HPLC. The two compounds were identified by tandem Q-TOF mass spectroscopy as C16 fengycin A (1) and a new fengycin with an aminobutyric acid at position 6 of the peptide backbone (2). Both compounds showed significant inhibitory activities against five plant fungal pathogens in paper-agar disk diffusion assay. This is the first report on the anti-fungal activities of the rare 6-Abu fengycin lipopeptides, and at the same time provided an insight into the potential of marine microbial resource in biological control and sustainable agriculture.
authors.affiliation: Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
authors.forename: Jiangchun
authors.initials: J
authors.lastname: Hu
authors.forename: Shujin
authors.initials: S
authors.lastname: Wang
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001407:Bacillus / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D055666:Lipopeptides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D055666:Lipopeptides