title: Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma.
abstract: Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve. Most manifest clinically with tinnitus, unilateral sensorineural hearing loss, and dysequilibrium secondary to compression of the vestibulocochlear nerve; major adverse events such as intratumoral hemorrhage causing acute neurologic deterioration are rare. We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities. The patient began having progressively worsening neurologic symptoms, including facial nerve paralysis and dysequilibrium, which confined him to a wheelchair. After presentation, the patient was admitted to the hospital. Several days after alteration of his anticoagulation therapy in preparation for surgery, he developed intracranial hemorrhage. Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome. During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma. The literature for intratumoral hemorrhage into vestibular schwannoma and the pathologic findings in our case are reviewed.
authors.affiliation: The Ohio State University, Dept of Otolaryngology-Head and Neck Surgery, OSU Eye and Ear Institute, 915 Olentangy River Rd, Columbus, OH 43212, USA.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Yates
authors.forename: Mitchell
authors.initials: M
authors.lastname: Weinberg
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Packer
authors.forename: Abraham
authors.initials: A
authors.lastname: Jacob
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D015897:Comorbidity; D018450:Disease Progression; D017809:Fatal Outcome; D006350:Heart Valve Prosthesis; D006801:Humans; D007150:Immunohistochemistry; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009464:Neuroma, Acoustic / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D012189:Retrospective Studies; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin