Fibronectin glomerulopathy in a 34-year-old man: a case report.
Fibronectin glomerulopathy is an inherited non-immune-mediated glomerulopathy associated with the massive deposition of fibronectin. It presents with proteinuria, microscopic hematuria, and hypertension that lead to end-stage renal failure in the second to sixth decade of life. A 34-year-old male was referred with proteinuria (6 g/day), microscopic hematuria and hypertension (220/130 mmHg). Renal biopsy specimen showed massive deposits of fibronectin in the mesangium and subendothelial spaces. After 20 months of multidrug treatment his renal function is stable.
Brcić
Iva
I
Clinical Department of Pathology and Cytology, University Hospital Center Zagreb, Zagreb, Croatia.
Brcić
Luka
L
Kuzmanić
Dusko
D
Corić
Mario
M
Corić
Marijana
M
D000328:Adult; D005353:Fibronectins / Q000378:metabolism*; D005920:Glomerular Mesangium / Q000378:metabolism / Q000648:ultrastructure; D006417:Hematuria / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D011507:Proteinuria / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D016896:Treatment Outcome
D005353:Fibronectins