title: Metabolic networks of longevity.
abstract: Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.
authors.affiliation: Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
authors.forename: Riekelt H
authors.initials: RH
authors.lastname: Houtkooper
authors.forename: Robert W
authors.initials: RW
authors.lastname: Williams
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000601:Amino Acids, Essential / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008136:Longevity; D053858:Metabolic Networks and Pathways; D008715:Methionine / Q000378:metabolism*
chemical_list: D000601:Amino Acids, Essential; D008715:Methionine