title: Neuromodulation of decision-making in the addictive brain.
abstract: Noninvasive brain stimulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation and transcranial direct current stimulation can modify decision-making behaviors in healthy subjects. The same type of noninvasive brain stimulation can suppress drug craving in substance user patients, who often display impaired decision-making behaviors. We discuss the implications of these studies for the cognitive neurosciences and their translational applications to the treatment of addictions. We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders.
authors.affiliation: Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. sfecteau@bidmc.harvard.edu
authors.forename: Shirley
authors.initials: S
authors.lastname: Fecteau
authors.forename: Felipe
authors.initials: F
authors.lastname: Fregni
authors.forename: Paulo S
authors.initials: PS
authors.lastname: Boggio
authors.forename: Joan A
authors.initials: JA
authors.lastname: Camprodon
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pascual-Leone
mesh_terms: D016739:Behavior, Addictive / Q000523:psychology*; D001921:Brain / Q000502:physiology*; D003657:Decision Making; D006801:Humans; D008954:Models, Biological; D018377:Neurotransmitter Agents; D050781:Transcranial Magnetic Stimulation
chemical_list: D018377:Neurotransmitter Agents