title: Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.
abstract: Zonisamide, originally known as an antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of Parkinson's disease (PD). Although zonisamide reduces neurotoxicity, the precise mechanism of this action is not known. Here, we show that zonisamide increases cell viability in SH-SY5Y cells via an anti-apoptotic effect and by upregulating levels of manganese superoxide dismutase (MnSOD). These results would give us novel evidences of PD treatment.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
authors.forename: Sumihiro
authors.initials: S
authors.lastname: Kawajiri
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Machida
authors.forename: Shinji
authors.initials: S
authors.lastname: Saiki
authors.forename: Shigeto
authors.initials: S
authors.lastname: Sato
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D020287:In Situ Nick-End Labeling / Q000379:methods; D007555:Isoxazoles / Q000494:pharmacology*; D009447:Neuroblastoma / Q000473:pathology; D009498:Neurotoxins / Q000494:pharmacology; D019311:Staurosporine / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects*; D000078305:Zonisamide
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D007555:Isoxazoles; D009498:Neurotoxins; D000078305:Zonisamide; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D013482:Superoxide Dismutase; D020169:Caspases; D019311:Staurosporine; D004298:Dopamine