title: Small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation: a case report.
abstract: BACKGROUND
  The group of small blue round cell tumors encompasses a heterogeneous group of neoplasms characterized by primitive appearing round cells with few distinguishing histologic features.
  
  
  RESULTS
  We report the case of a small blue round cell tumor with an EWS gene rearrangement detected by fluorescent in situ hybridization (FISH) analysis that mimicked Ewing sarcoma, but with unusual histology and immunohistochemical features. Multi-color karyotyping identified the presence of a t(2;22)(q34;q12) that was initially expected to represent a variant EWSR1-FEV translocation. After an extensive workup, the lesion is considered to represent a clear cell sarcoma harboring an EWSR1-CREB1 fusion transcript.
  
  
  CONCLUSIONS
  This case appears to represent a rare variant of clear cell sarcoma arising in peripheral soft tissues with unusual histology and unique immunophenotype. In this circumstance, FISH for all EWSR1 translocation partners or RT- PCR for a spectrum of possible transcript variants is critically important for diagnosis, since cytogenetic analysis or clinical FISH assay using only commercial EWSR1 probes will be misleading.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. torsten@interchange.ubc.ca.
authors.forename: Marina
authors.initials: M
authors.lastname: Pacheco
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Horsman
authors.forename: Malcolm M
authors.initials: MM
authors.lastname: Hayes
authors.forename: Paul W
authors.initials: PW
authors.lastname: Clarkson
authors.forename: Hassan
authors.initials: H
authors.lastname: Huwait
authors.forename: Torsten O
authors.initials: TO
authors.lastname: Nielsen