title: Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.
abstract: Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY, USA.
authors.forename: Hope H
authors.initials: HH
authors.lastname: Wu
authors.forename: Samiah
authors.initials: S
authors.lastname: Zafar
authors.forename: Youming
authors.initials: Y
authors.lastname: Huan
authors.forename: Herman
authors.initials: H
authors.lastname: Yee
authors.forename: Luis
authors.initials: L
authors.lastname: Chiriboga
authors.forename: Beverly Y
authors.initials: BY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology*; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin