Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal.
Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette.
Koledova
Zuzana
Z
Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. zkoledova@gmail.com
Krämer
Alwin
A
Kafkova
Leona Raskova
LR
Divoky
Vladimir
V
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation; D002455:Cell Division / Q000502:physiology*; D049109:Cell Proliferation; D018385:Centrosome / Q000378:metabolism*; D004249:DNA Damage; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology