Independent mechanisms for ventriloquism and multisensory integration as revealed by theta-burst stimulation.
The visual and auditory systems often concur to create a unified perceptual experience and to determine the localization of objects in the external world. Co-occurring auditory and visual stimuli in spatial coincidence are known to enhance performance of auditory localization due to the integration of stimuli from different sensory channels (i.e. multisensory integration). However, auditory localization of audiovisual stimuli presented at spatial disparity might also induce a mislocalization of the sound towards the visual stimulus (i.e. ventriloquism effect). Using repetitive transcranial magnetic stimulation we tested the role of right temporoparietal (rTPC), right occipital (rOC) and right posterior parietal (rPPC) cortex in an auditory localization task in which indices of ventriloquism and multisensory integration were computed. We found that suppression of rTPC excitability by means of continuous theta-burst stimulation (cTBS) reduced multisensory integration. No similar effect was found for cTBS over rOC. Moreover, inhibition of rOC, but not of rTPC, suppressed the visual bias in the contralateral hemifield. In contrast, cTBS over rPPC did not produce any modulation of ventriloquism or integrative effects. The double dissociation found in the present study suggests that ventriloquism and audiovisual multisensory integration are functionally independent phenomena and may be underpinned by partially different neural circuits.
Bertini
Caterina
C
Dipartimento di Psicologia, Università di Bologna, Viale Berti Pichat 5, 40127 Bologna, Italy. caterina.bertini@unibo.it
Leo
Fabrizio
F
Avenanti
Alessio
A
Làdavas
Elisabetta
E
D000161:Acoustic Stimulation; D000328:Adult; D000465:Algorithms; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000502:physiology; D010775:Photic Stimulation; D013017:Sound Localization / Q000502:physiology; D013826:Theta Rhythm; D050781:Transcranial Magnetic Stimulation; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult