title: Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8.
abstract: We present the first transcriptional regulatory element found in a PAH gene intron. The element is located in the PAH gene intron 8, acts as an enhancer specifically in the hepatoma cell line, and binds GATA-1 transcription factor. Herein the presented data could unlock a new area for the analysis of PAH gene expression and could contribute to refining genotype-phenotype correlation.
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, Belgrade, Serbia. maja.stojiljkovic@imgge.bg.ac.rs
authors.forename: Maja
authors.initials: M
authors.lastname: Stojiljkovic
authors.forename: Branka
authors.initials: B
authors.lastname: Zukic
authors.forename: Natasa
authors.initials: N
authors.lastname: Tosic
authors.forename: Teodora
authors.initials: T
authors.lastname: Karan-Djurasevic
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasovski
authors.forename: Gordana
authors.initials: G
authors.lastname: Nikcevic
authors.forename: Sonja
authors.initials: S
authors.lastname: Pavlovic
mesh_terms: D002478:Cells, Cultured; D050982:GATA1 Transcription Factor / Q000235:genetics; D007438:Introns / Q000235:genetics*; D010651:Phenylalanine Hydroxylase / Q000235:genetics* / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D050982:GATA1 Transcription Factor; D010651:Phenylalanine Hydroxylase