title: Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation.
abstract: Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.
authors.affiliation: Department of Cellular Biology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. Yuewt2000@yahoo.com
authors.forename: WenTao
authors.initials: W
authors.lastname: Yue
authors.forename: XiaoTing
authors.initials: X
authors.lastname: Zhao
authors.forename: LiNa
authors.initials: L
authors.lastname: Zhang
authors.forename: ZhiDong
authors.initials: Z
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: WenYun
authors.initials: W
authors.lastname: Jia
authors.forename: Zhe
authors.initials: Z
authors.lastname: Qian
authors.forename: ChunYan
authors.initials: C
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: XueHui
authors.initials: X
authors.lastname: Yang
authors.forename: ShaoFa
authors.initials: S
authors.lastname: Xu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016213:Cyclins / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen
chemical_list: C543319:CCNY protein, human; D016213:Cyclins; D018809:Proliferating Cell Nuclear Antigen