title: The uses and limitations of whole-body magnetic resonance imaging.
abstract: BACKGROUND
  Whole-body magnetic resonance imaging (WB-MRI) is a modern imaging method, free of ionizing radiation, which provides high-resolution display of individual organ systems and of the anatomy of the entire body.
  
  
  METHODS
  Selective literature review
  
  
  RESULTS
  Multi-channel WB-MRI scanners enable both the high-resolution imaging of the entire body and focused studies of individual organs, through the use of various sequence techniques and contrast modes. The initial application of combined cardiovascular and oncological imaging protocols for the screening of asymptomatic persons has already revealed many cases of cardiovascular disease and of tumors with serious clinical implications. The diagnostic accuracy of M staging with WB-MRI lies in the range of 93% to 97%. WB-MRI provides good contrast of the bone marrow, and has thus been used for the diagnosis of malignant bone marrow disease as well: in particular, it is especially sensitive for multiple myeloma and plays an important role in prognostication and therapeutic decision-making in this disorder. To date, WB-MRI has not been shown to be superior to other diagnostic techniques with respect to hard endpoints, such as prolongation of survival. It also carries the risk of false positive findings.
  
  
  CONCLUSIONS
  Despite these encouraging results, undirected screening by WB-MRI without an appropriate indication, as is currently being practiced in many institutions, is decidedly inadvisable in view of its predicted diagnostic yield below 2% and the lack of evidence for its cost-effectiveness.
authors.affiliation: Institut für klinische Radiologie, Universitätsklinik Grosshadern, LMU München, München, Germany. gerwin.schmidt@med.uni-muenchen.de
authors.forename: Gerwin
authors.initials: G
authors.lastname: Schmidt
authors.forename: Dietmar
authors.initials: D
authors.lastname: Dinter
authors.forename: Maximilian F
authors.initials: MF
authors.lastname: Reiser
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000473:pathology; D002813:Chondrosarcoma / Q000175:diagnosis / Q000473:pathology; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000473:pathology; D018450:Disease Progression; D055088:Early Detection of Cancer / Q000295:instrumentation*; D042241:Early Diagnosis; D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000295:instrumentation*