Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: implications for disease progression and response to catheter ablation.
BACKGROUND
Lone atrial fibrillation (AF) is thought to be a benign type or an early stage of the disease.


OBJECTIVE
This study sought to compare the left atrium (LA) substrate using delayed-enhanced magnetic resonance imaging (DE-MRI) in patients with lone AF versus those with comorbidities.


METHODS
Forty of 333 included patients met criteria for lone AF. All patients underwent DE-MRI to quantify atrial fibrosis as a marker for structural remodeling (SRM) and underwent catheter ablation. Based on the degree of SRM, patients were staged into 4 groups: Utah I (≤5% LA wall enhancement), Utah II (>5% to ≤20%), Utah III (>20% to ≤35%), or Utah IV (>35%).


RESULTS
Distribution in Utah I to IV was comparable in patients with lone AF and non-lone AF. In both groups, a number of patients showed extensive SRM. Mean enhancement (14.08 ± 8.94 vs. 16.94 ± 11.37) was not significantly different between the 2 groups (P = .0721). In the lone AF group, catheter ablation was successful in suppressing AF in all of Utah I, 81.82% of Utah II, 62.5% of Utah III, and none of Utah IV patients. Similar results were achieved in the non-lone AF group. Outcome after ablation was significantly dependent on the SRM of the LA (P < .001).


CONCLUSIONS
The degree of LA structural remodeling as detected using DE-MRI is independent of AF type and associated comorbidities. Selecting appropriate treatment candidates based on the quality and quantity of atrial fibrosis using DE-MRI would improve procedural outcome and avoid unnecessary intervention.
Mahnkopf
Christian
C
Comprehensive Arrhythmia and Research Management (CARMA) Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Badger
Troy J
TJ
Burgon
Nathan S
NS
Daccarett
Marcos
M
Haslam
Thomas S
TS
Badger
Christopher T
CT
McGann
Christopher J
CJ
Akoum
Nazem
N
Kholmovski
Eugene
E
Macleod
Rob S
RS
Marrouche
Nassir F
NF
D000328:Adult; D001281:Atrial Fibrillation / Q000473:pathology* / Q000601:surgery; D017115:Catheter Ablation; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D006325:Heart Atria / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
D003287:Contrast Media