title: Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Eralpha36 and the transformation of MCF10ACE.
abstract: ERalpha36, a variant of estrogen receptor-alpha, acts as a dominant-negative factor in both estrogen-dependent and estrogenindependent transactivation signaling pathways, and is a key factor in the promotion, progression and prognosis of breast cancers. Caveolin-1, a 22- to 24-kD integral membrane protein, may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways. It was shown that downregulation of Caveolin-1 strengthens the interaction of ERalpha and Caveolin-1. In conclusion, Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERalpha36-dependent way. Our finding may provide a promising therapeutic target of breast cancer.
authors.affiliation: College of Life Science, Liaoning Normal University, Dalian, 116029, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Zhaoyi
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuying
authors.initials: Y
authors.lastname: Cui
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Chunhui
authors.initials: C
authors.lastname: Zhao
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Zou
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D051242:Caveolin 1 / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D005260:Female; D020868:Gene Silencing; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000502:physiology
chemical_list: D051242:Caveolin 1; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt