[Preparation and study in vitro of 20 (S)-protopanaxadiol pharmacosomes].
To prepare and evaluate in vitro the 20 (S) -Protopanaxadiol (Ppd) pharmacosome. The Ppd pharmacosome was successfully prepared by thin film-dispersion and its stability in vitro was studied. The particle size of pharmacosome was evaluated by dynamic scattering (DLS) and the encapsulation efficiency was determined by using centrifugal ultra-filtration. The encapsulation efficiency of Ppd pharmacosome was (80.84 +/- 0.53)% with the diameter of 100. 1 nm; While the encapsulation efficiency of Ppd pharmacosome that added Brij 78 added was (72.76 +/- 0.63)% with the diameter of 117. 3 nm. In addition, the effect of some factors on the encapsulation efficiency and the particles size, such as temperature, alcohol, pH and artificial gastrointestinal fluids, were investigated respectively. The selected formulation and technology are simple and practical to prepare Ppd pharmacosome and preparation properties are more stable.
Han
Meihua
M
Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal Plant Development, Beijing 100193, China. hanmeihua727@163.com
Chen
Jing
J
Chen
Shilin
S
Wang
Xiangtao
X
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry; D005744:Gastric Acid / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008027:Light; D010316:Particle Size; D012502:Sapogenins / Q000737:chemistry* / Q000378:metabolism; D012542:Scattering, Radiation; D013696:Temperature
D012502:Sapogenins; D000431:Ethanol; C062916:protopanaxadiol