title: Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms.
abstract: We report the concentrations of maraviroc in the cerebrospinal fluid (CSF) and plasma of six HIV-1-infected patients with both neurological impairment and detectable HIV-1 replication in CSF. One month after starting maraviroc, the viral load in the CSF decreased significantly (P = 0.005). The median (range) maraviroc concentration in plasma was 347 ng/ml (123-2678). Four patients had CSF concentrations above the protein-adjusted inhibitory concentration (IC90) of 0.57 ng/ml (0.06-10.7) with a median of 102 ng/ml (35-173).
authors.affiliation: Department of Clinical Immunology, Henri Mondor Hospital, Université Paris XII Creteil, Creteil, France. giovanna.melica@hmn.aphp.fr
authors.forename: Giovanna
authors.initials: G
authors.lastname: Melica
authors.forename: Ana
authors.initials: A
authors.lastname: Canestri
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Jean D
authors.initials: JD
authors.lastname: Lelievre
authors.forename: Magali
authors.initials: M
authors.lastname: Bouvier-Alias
authors.forename: Cyril
authors.initials: C
authors.lastname: Clavel
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne S
authors.initials: AS
authors.lastname: Lascaux
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Yves
authors.initials: Y
authors.lastname: Levy
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000821:virology; D003510:Cyclohexanes / Q000493:pharmacokinetics*; D005260:Female; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D000077592:Maraviroc; D008875:Middle Aged; D014230:Triazoles / Q000493:pharmacokinetics*
chemical_list: D019380:Anti-HIV Agents; D003510:Cyclohexanes; D014230:Triazoles; D000077592:Maraviroc