Role of brominated diphenly ether-209 in the differentiation of neural stem cells in vitro.
Brominated diphenly ether-209 (BDE-209, decaBDE) is among the most common flame retardants. In a previous study, it was confirmed that exposure to BDE-209 can decrease learning and memory in mice. However, it is still unknown whether BDE-209 has an effect on cultured neural stem cells (NSCs). To analyse the role of BDE-209 in the differentiation of neural stem cells, NSCs obtained from neonatal rats were cultured as neurospheres in DMEM/F12 medium that contained different concentrations of BDE-209 for 7 days. BDE-209 was found to inhibit neurite outgrowth and the differentiation of NSCs into neurons in a concentration-dependent manner. BDE-209 also enhanced the ratio of differentiation of NSCs into glial cells.
Zhang
Chunfang
C
The Third Affiliated Hospital of Guangzhou Medical College, The Medical Center for Critical Pregnant Women in Guangzhou, Guangzhou, China.
Liu
Xianbao
X
Chen
Dunjin
D
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D055768:Halogenated Diphenyl Ethers / Q000008:administration & dosage*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D016501:Neurites / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure*; D009474:Neurons / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D055768:Halogenated Diphenyl Ethers