Gadolinium chloride augments tumor-specific imaging of targeted quantum dots in vivo.
Nonspecific sequestration of nanoparticles by the reticulo-endothelial system (RES) results in the degradation of image quality of nanoparticle-based imaging. We demonstrate that gadolinium chloride (GdCl3) pretreatment inactivates RES macrophages, thereby increasing circulatory time and amplifying the tumor-specific signal of conjugated nanoparticles in vivo. The experimental results were validated using compartmental modeling, and the rate parameters for the observed kinetics pattern were estimated. This pretreatment strategy could have broad applicability across biomedical applications utilizing theranostic nanoparticles that are sequestered by the RES.
Diagaradjane
Parmeswaran
P
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Deorukhkar
Amit
A
Gelovani
Juri G
JG
Maru
Dipen M
DM
Krishnan
Sunil
S
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000378:metabolism; D005682:Gadolinium / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008954:Models, Biological; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000378:metabolism / Q000493:pharmacokinetics; D009369:Neoplasms / Q000378:metabolism*; D045663:Quantum Dots; D015203:Reproducibility of Results
D015335:Molecular Probes; D005682:Gadolinium; D066246:ErbB Receptors; C038958:gadolinium chloride