A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.
Gattinoni
Sonia
S
DISMA, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.
Simone
Chiara De
CD
Dallavalle
Sabrina
S
Fezza
Filomena
F
Nannei
Raffaella
R
Battista
Natalia
N
Minetti
Patrizia
P
Quattrociocchi
Gianandrea
G
Caprioli
Antonio
A
Borsini
Franco
F
Cabri
Walter
W
Penco
Sergio
S
Merlini
Lucio
L
Maccarrone
Mauro
M
D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D010091:Oximes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D063385:Cannabinoid Receptor Modulators; D002219:Carbamates; D004791:Enzyme Inhibitors; D010091:Oximes; D000099252:Fatty Acid Amide Hydrolases