Long-term outcome of transurethral injection of hyaluronic acid/dextranomer (NASHA/Dx gel) for the treatment of stress urinary incontinence (SUI).
OBJECTIVE
To investigate the long-term safety and efficacy of transurethral injection of NASHA/Dx gel in women suffering from stress urinary incontinence (SUI).


METHODS
Women with SUI treated with NASHA/Dx gel via the transurethral Implacer device at Mayday University Hospital between November 2002 and December 2003 had long-term outcomes of therapy evaluated.


RESULTS
Eighteen of 21 were followed-up at mean 6.7 years (±SD 0.15). One year after the injection, 11/21 (52.3%) reported improvement. Of the women, 6/21 (28.5%) had a repeat injection and seven (33.3%) women experienced adverse events in the form of periurethral swellings. At 6.7 years, only one of seven women was continent of urine without requiring any further continence procedure, 44.4% were still experiencing SUI symptoms. Nine of 18 (42.8%) had undergone other continence procedures.


CONCLUSIONS
Transurethral injection of NASHA/Dx gel in women with SUI is associated with complications and not effective in the long term.
Lone
Farah
F
Department of Obstetrics and Gynaecology, Mayday University Hospital, 530 London Road, Croydon CR7 7YE, Surrey.
Sultan
Abdul H
AH
Thakar
Ranee
R
D000328:Adult; D000368:Aged; D003911:Dextrans / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D007267:Injections; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014521:Urethra; D014550:Urinary Incontinence, Stress / Q000628:therapy*
D003911:Dextrans; D005782:Gels; C487487:dextranomer-hyaluronic acid copolymer; D006820:Hyaluronic Acid