WT1 peptide immunotherapy for cancer in children and young adults.
Wilms tumor gene (WT1) can be overexpressed in childhood cancers. We evaluated the efficacy of WT1 vaccination for five children with solid cancer or acute leukemia. WT1 vaccine was administered to HLA-A*2402-positive patients with WT1-overexpressing residual tumor despite prior conventional treatment. One patient showed complete response and one patient showed stable disease according to the Response Evaluation Criteria in Solid Tumors; the remaining three showed progressive disease. Treatment-related adverse effects were limited to local injection site erythema. These results suggest that WT1 vaccination has therapeutic potential, but any beneficial effect may be insufficient in the presence of gross residual disease.
Hashii
Yoshiko
Y
Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.
Sato
Emiko
E
Ohta
Hideaki
H
Oka
Yoshihiro
Y
Sugiyama
Haruo
H
Ozono
Keiichi
K
D000293:Adolescent; D002648:Child; D004890:Erythema / Q000139:chemically induced; D005260:Female; D015234:HLA-A Antigens; D059871:HLA-A24 Antigen; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007938:Leukemia / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000627:therapeutic use; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D016896:Treatment Outcome; D014611:Vaccination; D025721:WT1 Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D055815:Young Adult
D015234:HLA-A Antigens; C438506:HLA-A*24:02 antigen; D059871:HLA-A24 Antigen; D010446:Peptide Fragments; D025721:WT1 Proteins