title: Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial.
abstract: OBJECTIVE
  The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.
  
  
  METHODS
  Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.
  
  
  RESULTS
  Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.
  
  
  CONCLUSIONS
  UAE is a well-established alternative to hysterectomy about which patients should be counseled.
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands. s.m.vanderkooij@amc.uva.nl
authors.forename: Sanne M
authors.initials: SM
authors.lastname: van der Kooij
authors.forename: Wouter J K
authors.initials: WJ
authors.lastname: Hehenkamp
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Volkers
authors.forename: Erwin
authors.initials: E
authors.lastname: Birnie
authors.forename: Willem M
authors.initials: WM
authors.lastname: Ankum
authors.forename: Jim A
authors.initials: JA
authors.lastname: Reekers
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects / Q000379:methods*; D007045:Hysterectomy, Vaginal / Q000009:adverse effects / Q000379:methods; D053208:Kaplan-Meier Estimate; D007889:Leiomyoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009367:Neoplasm Staging; D010147:Pain Measurement; D010149:Postoperative Pain / Q000503:physiopathology; D017060:Patient Satisfaction; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D011446:Prospective Studies; D011788:Quality of Life; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000009:adverse effects / Q000379:methods*; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery*