title: Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.
abstract: Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.
authors.affiliation: Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA. jqd6@cdc.gov
authors.forename: Jan
authors.initials: J
authors.lastname: Drobeniuc
authors.forename: Jihong
authors.initials: J
authors.lastname: Meng
authors.forename: Gábor
authors.initials: G
authors.lastname: Reuter
authors.forename: Tracy
authors.initials: T
authors.lastname: Greene-Montfort
authors.forename: Natasha
authors.initials: N
authors.lastname: Khudyakova
authors.forename: Zoya
authors.initials: Z
authors.lastname: Dimitrova
authors.forename: Saleem
authors.initials: S
authors.lastname: Kamili
authors.forename: Chong-Gee
authors.initials: CG
authors.lastname: Teo
mesh_terms: D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000175:diagnosis*; D016752:Hepatitis E virus / Q000145:classification* / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014773:Virology / Q000379:methods*
chemical_list: D006508:Hepatitis Antibodies; D007075:Immunoglobulin M