Elevated corticosterone in the amygdala leads to persistent increases in anxiety-like behavior and pain sensitivity.
Corticosterone (CORT) localized to the amygdala induces anxiety-like behavior coupled with increased behavioral responses to visceral and somatic stimuli. In the current study, we investigated the long-term consequences of briefly exposing the amygdala to elevated levels of CORT with the hypothesis that modulation of the amygdala with CORT results in persistent increases in anxiety-like behavior and viscerosomatic sensitivity.
Myers
Brent
B
VA Medical Center, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. brent.myers@uc.edu
Greenwood-Van Meerveld
Beverley
B
D000631:Aminopyridines / Q000008:administration & dosage / Q000494:pharmacology; D000679:Amygdala / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D003106:Colon / Q000187:drug effects / Q000502:physiology; D003345:Corticosterone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004343:Drug Implants; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344
C529296:(3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine; D000631:Aminopyridines; D004343:Drug Implants; D003345:Corticosterone