title: Joint distraction and movement for repair of articular cartilage in a rabbit model with subsequent weight-bearing.
abstract: We have previously shown that joint distraction and movement with a hinged external fixation device for 12 weeks was useful for repairing a large articular cartilage defect in a rabbit model. We have now investigated the results after six months and one year. The device was applied to 16 rabbits who underwent resection of the articular cartilage and subchondral bone from the entire tibial plateau. In group A (nine rabbits) the device was applied for six months. In group B (seven rabbits) it was in place for six months, after which it was removed and the animals were allowed to move freely for an additional six months. The cartilage remained sound in all rabbits. The areas of type II collagen-positive staining and repaired soft tissue were larger in group B than in group A. These findings provide evidence of long-term persistence of repaired cartilage with this technique and that weight-bearing has a positive effect on the quality of the cartilage.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. CZI12265@nifty.com
authors.forename: T
authors.initials: T
authors.lastname: Nishino
authors.forename: F
authors.initials: F
authors.lastname: Chang
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.forename: H
authors.initials: H
authors.lastname: Mishima
authors.forename: N
authors.initials: N
authors.lastname: Ochiai
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D024043:Collagen Type II / Q000378:metabolism; D004195:Disease Models, Animal; D016267:External Fixators; D008297:Male; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D005082:Physical Exertion; D011817:Rabbits; D013977:Tibia / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D016474:Weight-Bearing / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D024043:Collagen Type II