title: Oral administration of an association of forskolin, rutin and vitamins B1 and B2 potentiates the hypotonising effects of pharmacological treatments in POAG patients.
abstract: OBJECTIVE
  Control of intraocular pressure is still the main strategy to treat glaucoma patients. Forskolin has already shown an ability to control intraocular pressure after topic administration, whereas rutin is known to improve ocular blood fl ow. Therefore, aim of this pilot study has been to observe whether administration of an association of oral forskolin and rutin to POAG patients under different regimens of medical therapy may contribute to their effects, further decreasing IOP values.
  
  
  METHODS
  Forskolin (a natural compound present in the crude extract of the plant Coleus Forskohlii) and rutin are the main ingredients of a food supplement commercially available in Italy. In an open label pilot study, 16 patients with POAG under treatment with different topical drugs and with stable IOP were given additional treatment with the food supplement for 40 days, and their IOP values measured at enrolment, at the end of treatment and 40 days after treatment interruption.
  
  
  RESULTS
  Further addition of forskolin and rutin to topical association treatments resulted in a further decrease of IOP by roughly 20% of the initial value. The effect was reversible upon suspension of the treatment.
  
  
  CONCLUSIONS
  These data show for the fi rst time that forskolin and rutin given through the oral route appear to reach the ocular district, where they can act in synergy with topical pharmacological treatments, and contribute to the control of intraocular pressure.
authors.affiliation: Ophthalmology Department of the University Clinic Umberto I, Sapienza University, Rome, Italy. pescosol@tiscali.it
authors.forename: N
authors.initials: N
authors.lastname: Pescosolido
authors.forename: A
authors.initials: A
authors.lastname: Librando
mesh_terms: D000284:Administration, Oral; D005576:Colforsin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012256:Riboflavin / Q000008:administration & dosage*; D012431:Rutin / Q000008:administration & dosage*; D013831:Thiamine / Q000008:administration & dosage*
chemical_list: D005576:Colforsin; D012431:Rutin; D012256:Riboflavin; D013831:Thiamine