title: Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype.
abstract: Gonadoblastoma is a rare gonadal tumor with tumor cells arranged in nests surrounded by ovarian stroma containing Leydig or lutein-type cells. In 50% of the cases, there is an overgrowth of germ cells with progression to dysgerminoma. A case of gonadoblastoma with coexisting dysgerminoma developing in both ovaries of a 20-year-old girl who had increased abdominal girth is presented here. A pelvic mass measuring 20 x 14 cm was detected by pelvic ultrasonography. Bilateral salphingo-oophorectomy was performed. The histopathological report revealed bilateral gonadoblastoma with coexisting dysgerminoma. After surgery the patient received radiation and chemotherapy (BEP: bleomycin, etoposide, cisplatin) and was started on hormone replacement therapy. Five years and eight months after treatment, the patient is well and free of recurrence.
authors.affiliation: Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com
authors.forename: Bulent
authors.initials: B
authors.lastname: Yilmaz
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
authors.forename: Hatice
authors.initials: H
authors.lastname: Bayramoglu
authors.forename: Sunullah
authors.initials: S
authors.lastname: Soysal
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D004407:Dysgerminoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D018238:Gonadoblastoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult