title: CD-NP: an innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease.
abstract: The natriuretic peptide (NP) family consists of structurally similar, although physiologically distinct, peptides that play an important role in cardiorenal homeostasis. CD-NP is a novel chimeric natriuretic peptide developed by the Mayo Clinic, in which the 15-amino acid COOH-terminus of dendroaspis NP is fused to C-type NP. CD-NP is a dual activator of NP receptors A and B, and therefore, possesses the strong antiproliferative and antifibrotic properties of C-type NP with the potent natriuretic, diuretic, and aldosterone-inhibiting properties of dendroaspis NP. CD-NP has favorable cardiorenal properties when compared to recombinant B-type NP (nesiritide), including preservation of glomerular filtration rate with minimal blood pressure-lowering effects. Thus, CD-NP has emerged as an appealing novel therapeutic strategy for heart failure. The endogenous NP system, the development rationale for CD-NP, as well as in vitro, animal, and human studies and future directions will be reviewed.
authors.affiliation: Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA. mckie.paul@mayo.edu
authors.forename: Paul M
authors.initials: PM
authors.lastname: McKie
authors.forename: S Jeson
authors.initials: SJ
authors.lastname: Sangaralingham
authors.forename: John C
authors.initials: JC
authors.lastname: Burnett
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D002678:Chimera; D004232:Diuretics / Q000494:pharmacology; D015195:Drug Design; D004546:Elapid Venoms / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000187:drug effects; D020098:Natriuretic Peptide, C-Type / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology; D050705:Receptors, Guanylate Cyclase-Coupled / Q000378:metabolism*
chemical_list: D000959:Antihypertensive Agents; C075597:Dendroaspis natriuretic peptide; D004232:Diuretics; D004546:Elapid Venoms; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D020098:Natriuretic Peptide, C-Type; D050705:Receptors, Guanylate Cyclase-Coupled