The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity.
BACKGROUND
Women live longer than men. Some possible reasons for this advantage are the protection provided by high concentrations of 17β-estradiol (E2) during the premenopausal period and polymorphic variants of the estrogen receptors (ERs), which mediate various cardiovascular functions of E2.


METHODS
We tested whether the -351A/G and -397T/C polymorphisms of the ERα-encoding ESR1 were associated with extreme longevity. The genomic DNA of 148 centenarians (C), 414 young controls (Y), and 208 myocardial infarction patients (MI) was analyzed by RFLP-PCR.


RESULTS
Both polymorphisms were equally distributed in the Y, C, and in centenarians never diagnosed with MI (HC). In centenarians, none of these polymorphisms was associated with a particular lipid profile. The AA genotype of the -351A/G polymorphism was less frequent in the C, HC and Y groups than in MI patients (p=0.058, p=0.021, and p=0.004, respectively). In MI patients, the GG genotype of the -351A/G polymorphism was associated with significantly lower mean total cholesterol, LDL, and HDL levels compared to the AG (p=0.0194, p=0.0213, and p=0.0367, respectively) and AA genotypes (p=0.0014, p=0.0078, and p=0.0448, respectively).


CONCLUSIONS
The -351A/G ESR1 polymorphism might be associated with MI, but not with extreme longevity.
Roszkowska-Gancarz
Malgorzata
M
Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, 99/103 Marymoncka Street, 01-813 Warsaw, Poland.
Kurylowicz
Alina
A
Polosak
Jacek
J
Ambroziak
Michal
M
Puzianowska-Kuznicka
Monika
M
D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha