title: Catheter-related bacteremia caused by methicillin-resistant coagulase negative staphylococci with elevated minimal inhibitory concentration for vancomycin.
abstract: Treatment of bacteremia caused by methicillin-resistant coagulase-negative staphylococci with vancomycin minimum inhibitory concentration ≥2 mg/L frequently requires central venous catheter removal in children with cancer. There are few data supporting efficacy and safety of antibiotic catheter lock or use of daptomycin or linezolid for this indication in children.
authors.affiliation: Infectious Diseases Unit, Department of Hematology and Oncology, G. Gaslini Children's Hospital, Genoa, Italy. eliocastagnola@opsedale-gaslini.ge.it
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
authors.forename: Roberto
authors.initials: R
authors.lastname: Bandettini
authors.forename: Ines
authors.initials: I
authors.lastname: Lorenzi
authors.forename: Ilaria
authors.initials: I
authors.lastname: Caviglia
authors.forename: Gianni
authors.initials: G
authors.lastname: Macrina
authors.forename: Angela
authors.initials: A
authors.lastname: Tacchella
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling; D016009:Chi-Square Distribution; D002648:Child; D003030:Coagulase / Q000378:metabolism; D017576:Daptomycin / Q000494:pharmacology; D006801:Humans; D000069349:Linezolid; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology; D011446:Prospective Studies; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014640:Vancomycin / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D003030:Coagulase; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D017576:Daptomycin