Diagnostic pitfalls in newborns and babies with blisters and erosions.
Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this paper we discuss by giving examples the process of making an accurate diagnosis of blistering skin diseases in the neonatal period on the basis of a diagnostic algorithm. In addition, we provide an overview of the rational use and the limitations of laboratory procedures such as microbial testing, routine light microscopy, immunofluorescence antigen mapping, transmission electron microscopy, and molecular genetic analysis.
Nischler
Elke
E
Department of Dermatology, eb-house Austria, Paracelsus Private Medical University Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria.
Klausegger
Alfred
A
Hüttner
Clemens
C
Pohla-Gubo
Gabriele
G
Diem
Anja
A
Bauer
Johann W
JW
Hintner
Helmut
H