Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.
Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, the insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report the complete genome sequence of S. bingchenggensis. The availability of the genome sequence of S. bingchenggensis should enable us to understand the biosynthesis of these structurally intricate antibiotics better and facilitate rational improvement of this strain to increase their titers.
Wang
Xiang-Jing
XJ
School of Life Science, Northeast Agricultural University, Harbin, China.
Yan
Yi-Jun
YJ
Zhang
Bo
B
An
Jing
J
Wang
Ji-Jia
JJ
Tian
Jun
J
Jiang
Ling
L
Chen
Yi-Hua
YH
Huang
Sheng-Xiong
SX
Yin
Min
M
Zhang
Ji
J
Gao
Ai-Li
AL
Liu
Chong-Xi
CX
Zhu
Zhao-Xiang
ZX
Xiang
Wen-Sheng
WS
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics; D004987:Ethers / Q000378:metabolism*; D016680:Genome, Bacterial / Q000235:genetics; D018942:Macrolides / Q000378:metabolism; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013141:Spiro Compounds / Q000378:metabolism*; D013302:Streptomyces / Q000145:classification / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004987:Ethers; D018942:Macrolides; D013141:Spiro Compounds; C452419:nanchangmycin; C027837:moxidectin