title: Thyroid function in breast cancer patients.
abstract: BACKGROUND
  Recent studies indicate a possible relationship between hypothyroidism and breast cancer in vivo. In addition, oestrogen-like effects of thyroid hormones on breast cancer cell growth are seen in vitro. Therefore, this study evaluated thyroid function in breast cancer patients, women with benign breast tumour and healthy controls.
  
  
  METHODS
  Breast cancer patients (n=65), women with carcinoma in situ (n=13) or benign breast tumour (n=27), and healthy controls (n=38) were included in the study. Thyroid history was reported. Thyroid hormones (fT4, fT3, TSH) and thyroid antibodies (TPO, TRAK and TG) were determined. Statistical analysis was performed by Mann-Whitney U and Fisher's exact test (p<0.005 significant).
  
  
  RESULTS
  fT3 and fT4 levels were highest in breast cancer patients, and differed significantly from controls (fT3 and fT4: p<0.001) as well as from patients with benign breast tumour (fT3: p=0.021; fT4: p=0.017). TSH was highest in the control group without reaching significance. With regard to TRAK antibodies, breast cancer patients showed the highest levels differing significantly from women with benign breast tumours (p=0.048).
  
  
  CONCLUSIONS
  Significant differences in fT3/fT4 as well as TRAK levels were observed among breast cancer patients, women with benign breast tumours and healthy controls. Further studies using larger patient groups are part of ongoing research.
authors.affiliation: Department of Obstetrics and Gynecology - Grosshadern, Ludwig Maximilians University, Munich, Germany. nina.ditsch@med.uni-muenchen.de
authors.forename: Nina
authors.initials: N
authors.lastname: Ditsch
authors.forename: Susanne
authors.initials: S
authors.lastname: Liebhardt
authors.forename: Franz
authors.initials: F
authors.lastname: Von Koch
authors.forename: Miriam
authors.initials: M
authors.lastname: Lenhard
authors.forename: Michael
authors.initials: M
authors.lastname: Vogeser
authors.forename: Christine
authors.initials: C
authors.lastname: Spitzweg
authors.forename: Julia
authors.initials: J
authors.lastname: Gallwas
authors.forename: Bettina
authors.initials: B
authors.lastname: Toth
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000150:complications / Q000503:physiopathology*; D016022:Case-Control Studies; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D011446:Prospective Studies; D012306:Risk; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D004967:Estrogens; D013963:Thyroid Hormones