Broad-range 16S rRNA PCR with cerebrospinal fluid may be unreliable for management of postoperative aseptic meningitis.
We previously demonstrated that discontinuing presumptive antibiotic treatment in cases of negative conventional cultures is safe and effective for patients with postoperative aseptic meningitis (PAM). Here, we prospectively investigated 32 patients with postoperative meningitis. All 26 patients with PAM diagnosed on the basis of conventional cultures demonstrated negative 16S rRNA PCR results. Our results suggest that the PCR technique does not change PAM management.
Zarrouk
Virginie
V
Department of Internal Medicine, Hôpital Beaujon, 100, Boulevard du Général Leclerc, 92110 Clichy, France.
Leflon-Guibout
Véronique
V
Robineaux
Sébastien
S
Kalamarides
Michel
M
Nicolas-Chanoine
Marie-Hélène
MH
Sterkers
Olivier
O
Fantin
Bruno
B
D002555:Cerebrospinal Fluid / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D016133:Polymerase Chain Reaction / Q000379:methods*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000628:therapy; D011446:Prospective Studies; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics
D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S