Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.
Garcia
José
J
Institut de Science et Ingénierie Supramoléculaires (ISIS-UMR 7006), Université de Strasbourg-CNRS, 8 allée Gaspard Monge, 67000 Strasbourg, France.
Barluenga
Sofia
S
Beebe
Kristin
K
Neckers
Len
L
Winssinger
Nicolas
N
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D051379:Mice; D015394:Molecular Structure; D012402:Rotenone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D001688:Biological Products; D018841:HSP90 Heat-Shock Proteins; D012402:Rotenone; C480848:tephrosin; C107676:deguelin