Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.
Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1(+/-)Hipk2(-/-) mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.
Inoue
Toshihiro
T
Department of Ophthalmology and Visual Science, Kumamoto University, Graduate School of Medical Sciences, Kumamoto, Japan. noel@da2.so-net.ne.jp
Kagawa
Tetsushi
T
Inoue-Mochita
Miyuki
M
Isono
Kyoichi
K
Ohtsu
Naoki
N
Nobuhisa
Ikuo
I
Fukushima
Mikiko
M
Tanihara
Hidenobu
H
Taga
Tetsuya
T
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics; D005123:Eye / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D007908:Lens, Crystalline / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000235:genetics; D012160:Retina / Q000378:metabolism; D012172:Retinaldehyde / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D012172:Retinaldehyde