title: Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.
abstract: Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with (213)Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. (213)Bi-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.
authors.affiliation: Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Bryan
authors.forename: Zewei
authors.initials: Z
authors.lastname: Jiang
authors.forename: Robertha C
authors.initials: RC
authors.lastname: Howell
authors.forename: Alfred
authors.initials: A
authors.lastname: Morgenstern
authors.forename: Frank
authors.initials: F
authors.lastname: Bruchertseifer
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Dadachova
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000908:Antibodies, Fungal / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001729:Bismuth / Q000627:therapeutic use; D001921:Brain / Q000382:microbiology; D015169:Colony Count, Microbial; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000382:microbiology; D051379:Mice; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000908:Antibodies, Fungal; D000935:Antifungal Agents; D011868:Radioisotopes; D000666:Amphotericin B; D001729:Bismuth