title: N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity.
abstract: The in vitro biological activity of N-benzylsalicylthioamides was evaluated against eight fungal strains by the broth microdilution method and the results were compared with those obtained with fluconazole. The compounds exhibited an in vitro antifungal activity against the fluconazole-susceptible as well as the fluconazole-resistant fungal strains. The biological activity was analyzed by quantitative structure-activity relationship (QSAR).
authors.affiliation: Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského, Hradec Králové, Czech Republic. Eva.Petrlikova@faf.cuni.cz
authors.forename: Eva
authors.initials: E
authors.lastname: Petrlíková
authors.forename: Karel
authors.initials: K
authors.lastname: Waisser
authors.forename: Vladimír
authors.initials: V
authors.lastname: Buchta
authors.forename: Petr
authors.initials: P
authors.lastname: Jílek
authors.forename: Marcela
authors.initials: M
authors.lastname: Vejsová
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D013854:Thioamides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D013854:Thioamides; D015725:Fluconazole