Fungal infections of the mucous membrane.
A clinical review of three potentially severe fungal diseases, which are characterized in many cases by mucosal involvement, is presented. They are paracoccidioidomycosis, histoplasmosis, and mucormycosis. Mucosal involvement for paracoccidioidomycosis and rhinocerebral mucormycosis is frequent. Thus, oral involvement may provide early clue for diagnosis. In paracoccidioidomycosis, the mucosal lesion classically shows superficial ulcers with granular appearance and hemorrhagic points, usually on lips, palate, and jugal mucosa. In mucormycosis, necrosis of the palate followed for purulent discharge is a hallmark of rhinocerebral disease. Treatment with amphotericin B desoxycholate or the new second-generation triazoles is highly efficacious.
Marques
Silvio Alencar
SA
Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu, UNESP-University Estadual Paulista, Botucatu, São Paulo, Brazil. smarques@fmb.unesp.br
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D002648:Child; D004334:Drug Administration Schedule; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D009059:Mouth Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D009061:Mouth Mucosa / Q000382:microbiology*; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
D000935:Antifungal Agents