title: [Sheshiliuhuang decoction on cytokines in patients with urinary tract infection].
abstract: OBJECTIVE
  To investigate the therapeutic effects of Sheshiliuhuang decoction on clinical outcomes and cytokines in patients with urinary tract infection (UTI).
  
  
  METHODS
  Ninety-two (92) patients were selected and randomly divided into 2 groups, the treatment group (n = 47) administered with Sheshiliuhuang decoction, one prescription, 2 times a day, while patients in the control group (n = 45) were given Sanjin pills, 3 pills a time, 3 times a day. The treatment lasted for 7 days. Clinical outcomes and serum levels of TNF-alpha, IL-6, IL-8 in both groups were examined before and after the treatment.
  
  
  RESULTS
  The clinical effective rate was 93.62% in the treatment group and 88.22% the control group, indicating a significant difference of P < 0.05. Before the treatment, the serum levels of TNF-alpha, IL-6, IL-8 of treatment group were significantly higher than those in the control group (P < 0.05). At the end of the treatment, serum levels of IL-6 and TNF-alpha in the treatment group were significantly decreased compared with the before treatment (P < 0.01) and those did in the control group (P < 0.01).
  
  
  CONCLUSIONS
  Serum cytokines of IL-6, IL-8, and TNF-alpha were significantly increased in patients with UTI. Sheshiliuhuang decoction, with the mechanisms of regulating IL-6, IL-8, TNF-alpha, is an effective agent in patients with UTI.
authors.affiliation: Hulunbuir Ctiy Hailar District Infectious Diseases Hospital, Hailar 021000, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Ding
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yijie
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000378:metabolism* / Q000628:therapy; D055815:Young Adult
chemical_list: D016207:Cytokines