Studies on the biodistribution of dextrin nanoparticles.
The characterization of biodistribution is a central requirement in the development of biomedical applications based on the use of nanoparticles, in particular for controlled drug delivery. The blood circulation time, organ biodistribution and rate of excretion must be well characterized in the process of product development. In this work, the biodistribution of recently developed self-assembled dextrin nanoparticles is addressed. Functionalization of the dextrin nanoparticles with a DOTA-monoamide-type metal chelator, via click chemistry, is described. The metal chelator functionalized nanoparticles were labelled with a gamma-emitting (153)Sm(3+) radioisotope and the blood clearance rate and organ biodistribution of the nanoparticles were obtained. The effect of PEG surface coating on the blood clearance rate and organ biodistribution of the nanoparticles was also studied.
Gonçalves
C
C
IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Minho University, Campus de Gualtar, 4710-057 Braga, Portugal.
Ferreira
M F M
MF
Santos
A C
AC
Prata
M I M
MI
Geraldes
C F G C
CF
Martins
J A
JA
Gama
F M
FM
D000818:Animals; D020650:Combinatorial Chemistry Techniques; D003912:Dextrins / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D053758:Nanoparticles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012493:Samarium / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014018:Tissue Distribution
D003912:Dextrins; D006573:Heterocyclic Compounds, 1-Ring; D013438:Sulfhydryl Compounds; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D011092:Polyethylene Glycols; D012493:Samarium