Three new antibacterial active diarylheptanoids from Alpinia officinarum.
Three new diarylheptanoids, together with ten known ones, were isolated from the ethanol extract from the rhizomes of Alpinia officinarum Hance. The structural identification of these compounds was mainly achieved by spectroscopic methods. The new compounds were elucidated as 7-(4", 5"-dihydroxy-3"-methoxyphenyl)-1-phenyl -4-heptene-3-one (1), 1, 7-diphenyl-5-heptene-3-one (2) and 4-phenethyl-1, 7-diphenyl -1-heptene-3, 5-dione (3), respectively. All of the compounds showed antibacterial activity against Helicobactor pylori. Especially, the three new compounds showed strong antibacterial activity against Hp-Sydney strain 1 with the MIC values of 9-12 μg/mL, and against Hp-F44 with the MIC values of 25-30 μg/mL.
Zhang
Bei-Bei
BB
Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Dai
Yuan
Y
Liao
Zhi-Xin
ZX
Ding
Li-Sheng
LS
D032429:Alpinia / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006536:Heptanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027343:Rhizome
C557531:1,7-diphenyl-5-heptene-3-one; C557533:4-phenethyl-1,7-diphenyl-1-heptene-3,5-dione; C557532:7-(4'',5''-dihydroxy-3''-methoxyphenyl)-1-phenyl-4-heptene-3-one; D000900:Anti-Bacterial Agents; D006536:Heptanes; D010936:Plant Extracts