title: Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.
abstract: We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).
authors.affiliation: Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom. greenek@cf.ac.uk
authors.forename: Elaine K
authors.initials: EK
authors.lastname: Green
authors.forename: Detelina
authors.initials: D
authors.lastname: Grozeva
authors.forename: Valentina
authors.initials: V
authors.lastname: Moskvina
authors.forename: Marian L
authors.initials: ML
authors.lastname: Hamshere
authors.forename: Ian R
authors.initials: IR
authors.lastname: Jones
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones
authors.forename: Liz
authors.initials: L
authors.lastname: Forty
authors.forename: Sian
authors.initials: S
authors.lastname: Caesar
authors.forename: Katherine
authors.initials: K
authors.lastname: Gordon-Smith
authors.forename: Christine
authors.initials: C
authors.lastname: Fraser
authors.forename: Ellie
authors.initials: E
authors.lastname: Russell
authors.forename: David
authors.initials: D
authors.lastname: St Clair
authors.forename: Allan H
authors.initials: AH
authors.lastname: Young
authors.forename: Nicol
authors.initials: N
authors.lastname: Ferrier
authors.forename: Anne
authors.initials: A
authors.lastname: Farmer
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Peter A
authors.initials: PA
authors.lastname: Holmans
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: Nick
authors.initials: N
authors.lastname: Craddock
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C547868:GABRR1 protein, human; D011963:Receptors, GABA-A