title: Noninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery.
abstract: OBJECTIVE
  Surgical repair of the aortic arch remains technically challenging and is associated with considerable morbidity and mortality. Cerebral oximetry is a noninvasive technology that can monitor the regional oxygen saturation of the frontal cortex. We hypothesized that magnitude and duration of decreased intraoperative regional oxygen saturation was associated with postoperative organ dysfunction. Additionally, we sought to identify regional oxygen saturation threshold values that are predictive of organ dysfunction.
  
  
  METHODS
  The intraoperative regional oxygen saturation values of 30 patients undergoing aortic arch surgery were recorded and analyzed. Postoperative complications were categorized as "major" and "minor." Severe adverse outcome, extubation time, intensive care unit length of stay, and hospital length of stay data were collected and compared with the integrals of regional oxygen saturation and time (area under the threshold) spent beneath predetermined absolute threshold limits.
  
  
  RESULTS
  Twenty subjects underwent hemiarch replacement, and 10 subjects received total aortic arch replacements. There were 30 major and 29 minor complications identified. Sixteen (53.3%) patients had at least 1 major complication. Logistic regression showed statistically significant associations between area under the threshold and severe adverse outcome incidence for regional oxygen saturation thresholds of 60% (P = .038) and 65% (P = .025). Patients who spent more than 30 minutes under the absolute threshold of 60% had an extended hospital stay of 4 days leading to an additional cost of $8300.00.
  
  
  CONCLUSIONS
  Our findings lend evidence to support the association of decreased perioperative cerebral oxygenation values with poor outcomes after aortic arch surgery.
authors.affiliation: Department of Anesthesiology, Mount Sinai School of Medicine, Mount Sinai Medical Center, New York, NY 10029, USA. Gregory.Fischer@mountsinai.org
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Fischer
authors.forename: Hung-Mo
authors.initials: HM
authors.lastname: Lin
authors.forename: Marina
authors.initials: M
authors.lastname: Krol
authors.forename: Maria F
authors.initials: MF
authors.lastname: Galati
authors.forename: Gabriele
authors.initials: G
authors.lastname: Di Luozzo
authors.forename: Randall B
authors.initials: RB
authors.lastname: Griepp
authors.forename: David L
authors.initials: DL
authors.lastname: Reich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000191:economics; D002315:Cardiopulmonary Bypass; D050792:Circulatory Arrest, Deep Hypothermia Induced; D003422:Critical Care; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006324:Heart Arrest, Induced; D017721:Hospital Costs; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000191:economics / Q000379:methods*; D009519:New York City; D010092:Oximetry / Q000191:economics; D010100:Oxygen / Q000378:metabolism*; D011183:Postoperative Complications / Q000191:economics / Q000209:etiology* / Q000628:therapy; D011237:Predictive Value of Tests; D012121:Respiration, Artificial; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010100:Oxygen