title: Pretreatment and early intratreatment prediction of clinicopathologic response of head and neck cancer to chemoradiotherapy using 1H-MRS.
abstract: OBJECTIVE
  To determine if choline (cho) identified by proton magnetic resonance spectroscopy ((1)H-MRS) performed pretreatment and early in the course of treatment predicts clinicopathologic response of head and neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  In all, 60 patients with HNSCC scheduled to undergo concurrent chemoradiotherapy or radiotherapy alone were recruited. (1)H-MRS was performed pretreatment and early intratreatment (2 weeks after start of treatment). Cho:creatine and cho:water ratios at each timepoint and change in the ratios between the two timepoints were correlated with locoregional failure, distant metastases, overall survival, and cancer-related death. Statistical analysis was performed using logistic regression and chi-square and a P-value of < 0.05 was considered statistically significant.
  
  
  RESULTS
  Cho was identified in 47/49 successful pretreatment spectra and 42 of these 47 underwent successful (1)H-MRS early intratreatment, of which 21 showed persistent cho. Locoregional failure occurred in 15, distant metastases in 6, and death in 15 patients; the follow-up period in survivors ranged from 13-64 months (mean, 39 months). No statistically significant correlation was found between (1)H-MRS parameters and clinical endpoints.
  
  
  CONCLUSIONS
  The pretreatment cho and change in cho early during a course of treatment did not predict clinical outcome.
authors.affiliation: Department of Diagnostic Radiology & Organ Imaging, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR China. king2015@cuhk.edu.hk
authors.forename: Ann D
authors.initials: AD
authors.lastname: King
authors.forename: David K W
authors.initials: DK
authors.lastname: Yeung
authors.forename: Kwok-hung
authors.initials: KH
authors.lastname: Yu
authors.forename: Frankie K F
authors.initials: FK
authors.lastname: Mo
authors.forename: Kunwar S
authors.initials: KS
authors.lastname: Bhatia
authors.forename: Gary M K
authors.initials: GM
authors.lastname: Tse
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Vlantis
authors.forename: Jeffrey K T
authors.initials: JK
authors.lastname: Wong
authors.forename: Chen-wen
authors.initials: CW
authors.lastname: Hu
authors.forename: Anil T
authors.initials: AT
authors.lastname: Ahuja
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy*; D002794:Choline / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002794:Choline