Patlak plot analysis CT-GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs.
Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single-slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT-derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 +/- 0.058 ml min(-1) ml renal tissue(-1)) compared with control dogs (0.396 +/- 0.139 ml min(-1) ml renal tissue(-1)). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R(2) = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT-GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models.
Alexander
K
K
Faculté de médecine vétérinaire, Université de Montréal, PO Box 5000, St-Hyacinthe, Quebec, J2S 7C6, Canada. kate.alexander@umontreal.ca
Authier
S
S
del Castillo
J R E
JR
Arora
V
V
Qi
S
S
Guillot
M
M
Beauchamp
G
G
Troncy
E
E
D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000502:physiology*; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology; D016030:Kidney Transplantation / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003404:Creatinine