Minor allele C of chromosome 1p32 single nucleotide polymorphism rs11206510 confers risk of ischemic stroke in the Chinese Han population.
OBJECTIVE
Genome-wide association studies found that the common allele T of single nucleotide polymorphism rs11206510 on chromosome 1p32 was associated with increased low-density lipoprotein-cholesterol levels (LDL-C) and with risk of coronary artery disease (CAD) in white populations. The goals of this study are to determine whether rs11206510 is associated with LDL-C and CAD in a different ethnic population, namely a Chinese cohort, and to investigate whether rs11206510 is associated with ischemic stroke.


METHODS
The association of rs11206510 with LDL-C was analyzed in 1415 Chinese Han subjects. The CAD study utilized a GeneID cohort with 1543 CAD patients and 1240 controls. For stroke studies, 2 independent cohorts were used and included the GeneID North cohort, with 1205 cases and 1205 controls, and the GeneID Central cohort, with 692 cases and 882 controls.


RESULTS
Different from white populations, the minor allele C of rs11206510 was associated with increased LDL-C levels in the Chinese Han population (adjusted P=0.002) and conferred risk of early-onset CAD (380 cases vs 1240 controls; adjusted P=0.002, odds ratio, 1.89), but not with overall CAD (adjusted P=0.82). The allelic association with ischemic stroke was highly significant in 2 independent cohorts, with adjusted P=1.13x10(-5) (odds ratio,1.71) in the GeneID North cohort and adjusted P=9.32x10(-5) (odds ratio, 1.70) in the GeneID Central cohort. Genotypic association was also significant for both early-onset CAD and ischemic stroke.


CONCLUSIONS
Our results indicate that single nucleotide polymorphism rs11206510 is associated with LDL-C levels and early-onset CAD in the Chinese Han population. For the first time to our knowledge, this study also demonstrates that rs11206510 confers a significant risk of ischemic stroke.
Xu
Chengqi
C
Key Laboratory of Molecular Biophysics of Ministry of Education, Integrated Traditional Chinese and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China.
Wang
Fan
F
Wang
Binbin
B
Li
Xiuchun
X
Li
Cong
C
Wang
Dan
D
Xiong
Xin
X
Wang
Pengyun
P
Lu
Qiulun
Q
Wang
Xiaojing
X
Yang
Qin
Q
Yin
Dan
D
Huang
Yufeng
Y
Ji
Liying
L
Wang
Nan
N
Chen
Shanshan
S
Cheng
Xiang
X
Liao
Yuhua
Y
Ma
Xu
X
Su
Dingfeng
D
Chen
Guohua
G
Xia
Hao
H
Shi
Lisong
L
Tu
Xin
X
Wang
Qing K
QK
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*