Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo.
Detection of high-risk coronary arterial plaques prior to rupture remains an unmet clinical challenge, in part due to the stringent resolution and sensitivity requirements for in vivo human coronary arterial imaging. To address this need, we have developed a near-infrared (NIR) fluorescence imaging catheter system for intra-vascular molecular imaging of atherosclerosis in coronary artery-sized vessels, capable of resolving two-dimensional fluorescence activity in hollow organs, such as blood vessels. Based on a rotational fiber design, the catheter system illuminates and detects perpendicular to the rotational axis, while an automated pullback mechanism enables visualization along blood vessels with a scan speed of up to 1.5 mm/sec. We demonstrate the previously undocumented capacity to produce intravascular NIR fluorescence images of hollow organs in vivo and showcase the performance metrics of the system developed using blood vessel mimicking phantoms. This imaging approach is geared toward in vivo molecular imaging of atherosclerotic biomarkers and is engineered to allow seamless integration into the cardiac catheterization laboratory.
Razansky
R Nika
RN
Biological Imaging, Technische Universität München and Institute for Biological and Medical Imaging, IBMI, Helmholtz Zentrum München, Munich, Germany. 1nika.razansky@tum.de
Rosenthal
Amir
A
Mallas
George
G
Razansky
Daniel
D
Jaffer
Farouc A
FA
Ntziachristos
Vasilis
V
D001158:Arteries / Q000033:anatomy & histology*; D002406:Catheterization, Peripheral; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007259:Infrared Rays; D008856:Microscopy, Fluorescence / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity