Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation.
Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.
Yue
WenTao
W
Department of Cellular Biology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. Yuewt2000@yahoo.com
Zhao
XiaoTing
X
Zhang
LiNa
L
Liu
ZhiDong
Z
Ma
Li
L
Jia
WenYun
W
Qian
Zhe
Z
Zhang
ChunYan
C
Wang
Yue
Y
Yang
XueHui
X
Xu
ShaoFa
S
D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016213:Cyclins / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen
C543319:CCNY protein, human; D016213:Cyclins; D018809:Proliferating Cell Nuclear Antigen