title: Pharmacoresistant epilepsy: from pathogenesis to current and emerging therapies.
abstract: Almost one-third of people with epilepsy continue to have seizures despite appropriate antiepileptic drug treatment, placing them at considerable risk of cognitive and psychosocial dysfunction and death. We recommend early referral to an epilepsy center when seizures are difficult to control.
authors.affiliation: Barrow Neurological Institute, Phoenix, AZ, USA.
authors.forename: Sandipan
authors.initials: S
authors.lastname: Pati
authors.forename: Andreas V
authors.initials: AV
authors.lastname: Alexopoulos
mesh_terms: D038481:Anterior Temporal Lobectomy; D000927:Anticonvulsants / Q000627:therapeutic use*; D003337:Corpus Callosum / Q000601:surgery; D055423:Diet, Ketogenic; D004351:Drug Resistance / Q000187:drug effects* / Q000235:genetics; D004558:Electric Stimulation; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D038421:Hemispherectomy; D006624:Hippocampus / Q000601:surgery; D006801:Humans; D008019:Life Style; D009820:Ohio; D010597:Pharmacogenetics; D018570:Risk Assessment; D017211:Treatment Failure; D055536:Vagus Nerve Stimulation
chemical_list: D000927:Anticonvulsants