title: Bilateral insufficiency fracture of the femoral head and neck in a case of oncogenic osteomalacia.
abstract: We describe a case of oncogenic osteomalacia in an adult male who presented with low back pain and bilateral hip pain. Extensive investigations had failed to find a cause. A plain pelvic radiograph showed Looser's zones in both femoral necks. MRI confirmed the presence of insufficiency fractures bilaterally in the femoral head and neck. Biochemical investigations confirmed osteomalacia which was unresponsive to treatment with vitamin D and calcium. A persistently low serum phosphate level suggested a diagnosis of hypophosphataemic osteomalacia. The level of fibroblast growth factor-23 was highly raised, indicating the cause as oncogenic osteomalacia. This was confirmed on positron-emission tomography, MRI and excision of a benign fibrous histiocytoma following a rapid recovery. The diagnosis of oncogenic osteomalacia may be delayed due to the non-specific presenting symptoms. Subchondral insufficiency fractures of the femoral head may be missed unless specifically looked for.
authors.affiliation: Department of Orthopaedics, King Edward VII Memorial Hospital, Parel, Mumbai-12, Maharastra, 400012, India. drvarunchouhan@yahoo.co.in
authors.forename: V
authors.initials: V
authors.lastname: Chouhan
authors.forename: K
authors.initials: K
authors.lastname: Agrawal
authors.forename: T K
authors.initials: TK
authors.lastname: Vinothkumar
authors.forename: A
authors.initials: A
authors.lastname: Mathesul
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005265:Femoral Neck Fractures / Q000175:diagnosis / Q000209:etiology; D005270:Femur Head / Q000293:injuries*; D015775:Fractures, Stress / Q000175:diagnosis / Q000209:etiology*; D006620:Hip Fractures / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D010018:Osteomalacia / Q000175:diagnosis / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000175:diagnosis; D013848:Thigh