title: Evaluation of evidence-based literature and formulation of recommendations for the clinical preventive guidelines for immigrants and refugees in Canada.
abstract: BACKGROUND
  This article describes the evidence review and guideline development method developed for the Clinical Preventive Guidelines for Immigrants and Refugees in Canada by the Canadian Collaboration for Immigrant and Refugee Health Guideline Committee.
  
  
  METHODS
  The Appraisal of Guidelines for Research and Evaluation (AGREE) best-practice framework was combined with the recently developed Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to produce evidence-based clinical guidelines for immigrants and refugees in Canada.
  
  
  RESULTS
  A systematic approach was designed to produce the evidence reviews and apply the GRADE approach, including building on evidence from previous systematic reviews, searching for and comparing evidence between general and specific immigrant populations, and applying the GRADE criteria for making recommendations. This method was used for priority health conditions that had been selected by practitioners caring for immigrants and refugees in Canada.
  
  
  CONCLUSIONS
  This article outlines the 14-step method that was defined to standardize the guideline development process for each priority health condition.
authors.affiliation: Institute of Population Health, University of Ottawa, Ottawa, Ont. Tugwellb@uottawa.ca
authors.forename: Peter
authors.initials: P
authors.lastname: Tugwell
authors.forename: Kevin
authors.initials: K
authors.lastname: Pottie
authors.forename: Vivian
authors.initials: V
authors.lastname: Welch
authors.forename: Erin
authors.initials: E
authors.lastname: Ueffing
authors.forename: Andrea
authors.initials: A
authors.lastname: Chambers
authors.forename: John
authors.initials: J
authors.lastname: Feightner
mesh_terms: D002170:Canada; D054242:Emigrants and Immigrants; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic; D011320:Primary Health Care; D012036:Refugees