title: Soluble P selectin in synovial fluid level is correlated with the radiographic severity of knee osteoarthritis.
abstract: BACKGROUND
  Recent studies provide evidence that inflammation is a feature of the disease process in Osteoarthritis (OA). The clinical significance of P selectin (Ps) in OA has not been adequately studied and the association between Ps level and OA severity remains unknown.
  
  
  METHODS
  We enrolled 120 knee OA subjects and 45 controls. All patients were scored for Kellgren-Lawrence grade (0-4). The Ps in serum and synovial fluid (SF) as well as serum C-reactive protein (CRP) levels were detected.
  
  
  RESULTS
  The mean Ps level in OA subjects was markedly increased than that in controls. In OA patients, the SF Ps levels increased with the severity of KL scores and significantly correlated with severity of disease (r=0.546, P<0.001) and serum CRP level (r=0.488, P<0.001). However, the serum Ps level did not show a significant correlation with the severity of OA.
  
  
  CONCLUSIONS
  The Ps levels in SF were significantly correlated with the severity of OA, suggesting that it may be used as a biomarker to evaluate the progression of OA.
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Cheng
authors.forename: Feng-Feng
authors.initials: FF
authors.lastname: Li
authors.forename: Song
authors.initials: S
authors.lastname: Zhao
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Peng
authors.forename: Xian-Long
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019007:P-Selectin / Q000032:analysis* / Q000097:blood; D011859:Radiography; D019087:Selectins / Q000032:analysis / Q000097:blood; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D019007:P-Selectin; D019087:Selectins; D002097:C-Reactive Protein