title: Guided deposition of individual DNA nanostructures on silicon substrates.
abstract: We demonstrate immobilization of DNA nanostructures (37 nm x 8 nm) on silicon by a combination of "top-down" fabrication and "bottom-up" self-assembly. Anchor lines and pads were defined using electron beam lithography and a cationic molecular monolayer. Individual DNA nanostructures bind in 85% yield onto the anchor pads and can be washed and imaged in air. The strength of the binding interaction between a DNA nanostructure and its anchor pad is at least -43 kJ/mol.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.forename: Koshala
authors.initials: K
authors.lastname: Sarveswaran
authors.forename: Gary H
authors.initials: GH
authors.lastname: Bernstein
authors.forename: Marya
authors.initials: M
authors.lastname: Lieberman
mesh_terms: D004247:DNA / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D012825:Silicon / Q000737:chemistry*
chemical_list: D004247:DNA; D012825:Silicon