title: Cell-to-cell movement of tobacco mosaic virus: enigmas and explanations.
abstract: Abstract Tobacco mosaic virus (TMV) spreads between cells through plant intercellular connections, the plasmodesmata. This transport process is mediated by a specialized virus-encoded movement protein, TMV MP. Recent advances in two major aspects of TMV MP function highlight the limits of our current knowledge and promise exciting future developments. First, findings that TMV MP interacts with cytoskeletal elements and cell wall proteins suggest potential mechanisms for TMV MP targeting from the cell cytoplasm to plasmodesmal channels. Second, indications that TMV MP phosphorylation plays a regulatory role in several activities of TMV MP begin to unravel molecular pathways that control TMV cell-to-cell transport. TMV systemic movement that follows its initial cell-to-cell spread, on the other hand, may be controlled through two different pathways used for viral entry into and exit from the host plant vascular tissue.
authors.affiliation: Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794-5215.
authors.forename: Y
authors.initials: Y
authors.lastname: Rhee
authors.forename: T
authors.initials: T
authors.lastname: Tzfira
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: E
authors.initials: E
authors.lastname: Waigmann
authors.forename: V
authors.initials: V
authors.lastname: Citovsky