title: Clinical profile of chikungunya sequelae, association with obesity and rest during acute phase.
abstract: The scarcity of literature regarding chikungunya infection sequelae makes it an unexplored area of medicine. We analyzed 1,111 patients with confirmed chikungunya sequelae and found a female predominance in those with sequelae which increased with age up to 40-50 years old, then decreased with further increase in age. In males age > 60 years old was the predominant age group affected. The symptoms were mainly symmetrical polyarthralgia of the proximal and distal interphalangeal joints. Dermatological manifestations were mainly hyper pigmented patches, generalized pruritus, and a maculopapular rash. Insomnia, fatigability and headache may indicate neurological involvement. Obesity gave an odds ratio of 2.07 for risk of arthritis. There was no significant benefit from rest during the acute phase (p < 0.001) of chikungunya in preventing chronicity of sequelae. Obesity as an independent risk factor for chronicity of chikungunya infection sequelae is a new finding.
authors.affiliation: Department of General Medicine, TD Medical College, Alappuzha, Kerala, India. rejeeshmenon007@gmail.com
authors.forename: B
authors.initials: B
authors.lastname: Padmakumar
authors.forename: Jacob B
authors.initials: JB
authors.lastname: Jayan
authors.forename: Rejeesh
authors.initials: R
authors.lastname: Menon
authors.forename: Arun Jose
authors.initials: AJ
authors.lastname: Kottarathara
mesh_terms: D000208:Acute Disease; D000328:Adult; D017677:Age Distribution; D018354:Alphavirus Infections / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D018771:Arthralgia / Q000150:complications*; D002646:Chikungunya virus; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012146:Rest; D017678:Sex Distribution