title: Proposed Mayo Clinic criteria for the diagnosis of Tako-Tsubo cardiomyopathy and long-term prognosis.
abstract: Tako-Tsubo cardiomyopathy (TTC) is a reversible cardiomyopathy with a clinical presentation indistinguishable from myocardial infarction. TTC is estimated to represent 1%-2% of patients presenting with acute myocardial infarction. It most commonly occurs in postmenopausal women and is frequently precipitated by a stressful event. Chest pain and dyspnea are the typical presenting symptoms. Transient ST-segment elevation on ECG and a small rise in cardiac biomarkers are common. Characteristic wall motion abnormalities extend beyond the territory of a single epicardial coronary artery in the absence of obstructive coronary lesions. Supportive treatment leads to spontaneous rapid recovery in nearly all patients. The prognosis is excellent, and recurrence occurs in < 10% of patients. In this article, we review the clinical features of TTC that form the basis of the Mayo Clinic diagnostic criteria, as well as the long-term prognosis for this type of cardiomyopathy.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, 55905, Rochester, Minnesota, USA.
authors.forename: M
authors.initials: M
authors.lastname: Madhavan
authors.forename: A
authors.initials: A
authors.lastname: Prasad
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003952:Diagnostic Imaging / Q000379:methods* / Q000592:standards*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D015995:Prevalence; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis* / Q000401:mortality*; D014481:United States
chemical_list: D015415:Biomarkers