title: Etanercept in a patient with severe psoriasis and latent viral hepatic disease and latent tuberculosis.
abstract: This case report describes the effective use of etanercept in a 63-year-old male patient with moderate to severe psoriasis and vitiligo unresponsive to local and systemic therapies. Latent tuberculosis was diagnosed at baseline and the patient was treated with isoniazid for 9 months. One month after starting isoniazid, etanercept therapy (12 weeks) for psoriasis was initiated. One month later, hepatitis B virus (HBV) markers were detected, but virological tests for active HBV were negative. Isoniazid and etanercept treatments were completed without incidence. Further clinical investigations are required to confirm the potential effects of anti-tumour necrosis factor alpha agents in such patients.
authors.affiliation: Department of Dermatology, S. Anna Hospital, via Napoleona 60, 22100 Como, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Prestinari
authors.forename: Guido
authors.initials: G
authors.lastname: Ferguglia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Laria
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D000068800:Etanercept; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012720:Severity of Illness Index; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014820:Vitiligo / Q000150:complications
chemical_list: D000995:Antitubercular Agents; D007074:Immunoglobulin G; D007155:Immunologic Factors; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept; D007538:Isoniazid