Myeloma-associated orbital amyloidosis.
Orbital amyloidosis is extremely rare and may be localized finding or secondary to a systematic process. The majority of the patients with orbital amyloidosis have primary localized disease. We report a 55 year old male with multiple myeloma and secondary amyloidosis who presented with incidental bilateral orbital masses on MRI. Biopsy revealed amyloid deposition. We review the previously published cases of the orbital amyloidosis secondary to systematic light chain (AL) amyloidosis, including one patient with multiple myeloma. The clinical signs and symptoms, histopathologic findings, and radiographic features of orbital amyloidosis are discussed.
Goshe
Jeff M
JM
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Schoenfield
Lynn
L
Emch
Todd
T
Singh
Arun D
AD
D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D009916:Orbital Diseases / Q000175:diagnosis / Q000209:etiology*