title: Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).
abstract: A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA.
authors.affiliation: Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA.
authors.forename: John
authors.initials: J
authors.lastname: Yang
authors.forename: Gwendolyn A
authors.initials: GA
authors.lastname: Marriner
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wang
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Bowman
authors.forename: Sean M
authors.initials: SM
authors.lastname: Kerwin
authors.forename: Salomon
authors.initials: S
authors.lastname: Stavchansky
mesh_terms: D002109:Caffeic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line; D019610:Cytoprotection / Q000187:drug effects*; D054879:Halogenation; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010627:Phenethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D002109:Caffeic Acids; D010627:Phenethylamines; D006861:Hydrogen Peroxide; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol