title: Paraspeckles.
abstract: Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.
authors.affiliation: Western Australian Institute for Medical Research and Centre For Medical Research, University of Western Australia, Crawley, 6009 Western Australia, Australia. archafox@waimr.uwa.edu.au
authors.forename: Archa H
authors.initials: AH
authors.lastname: Fox
authors.forename: Angus I
authors.initials: AI
authors.lastname: Lamond
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure*; D006801:Humans; D008856:Microscopy, Fluorescence; D013347:Subcellular Fractions / Q000502:physiology*