title: Genetic analysis of a hantavirus strain carried by Niviventer confucianus in Yunnan province, China.
abstract: Hantavirus genome sequences were recovered from lung tissues of Chinese white-bellied rats (Niviventer confucianus) captured in Yunnan province, China. Pairwise comparison of the nucleotide and deduced amino acid sequences of the entire S and partial M and L segments indicated that the newly discovered virus strain, which was designated as strain YN509, was very different from other rodent-borne hantaviruses. Phylogenetic analysis showed that the new strain fit into a clade containing Da Bie Shan virus (DBSV) (also carried by N. confucianus), which is mainly found in Anhui Province in mainland China. Strain YN509 appears to be in a sister taxa of the DBSV group described previously. These data suggest that strain YN509 is a new subtype of DBSV, which appears to be widely distributed in China with a higher genetic diversity than expected.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20-Dongda Street, Fengtai District, Beijing 100071, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Cao
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Zuo
authors.forename: Zheng-Da
authors.initials: ZD
authors.lastname: Gong
authors.forename: Lin
authors.initials: L
authors.lastname: Zhan
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Bian
authors.forename: Pan-He
authors.initials: PH
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Jiu-Song
authors.initials: JS
authors.lastname: Zhang
authors.forename: Qiu-Min
authors.initials: QM
authors.lastname: Zhao
authors.forename: Na
authors.initials: N
authors.lastname: Jia
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000818:Animals; D002681:China; D016000:Cluster Analysis; D006476:Orthohantavirus / Q000235:genetics* / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000662:veterinary* / Q000821:virology; D008168:Lung / Q000821:virology; D008969:Molecular Sequence Data; D051189:Murinae / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D051381:Rats; D012376:Rodent Diseases / Q000821:virology*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins