Selective detection of Hg2+ in the microenvironment of double-stranded DNA with an intercalator crown-ether conjugate.
9-[2-(1,4-Dioxa-7,13-dithia-10-azacyclopentadecyl)phenyl]amino-benzo[b]quinolizinium enables the unambiguous fluorimetric and polarimetric detection of Hg(2+) in the close proximity of double-stranded nucleic acids without interfering background signals from the complexes of this compound with Hg(2+) or DNA alone.
Tian
Maoqun
M
University of Siegen, Organic Chemistry II, Adolf-Reichwein-Str. 2, D-57068 Siegen, Germany.
Ihmels
Heiko
H
Benner
Katja
K
D043844:Crown Ethers / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005470:Fluorometry / Q000379:methods*; D007364:Intercalating Agents / Q000737:chemistry*; D008628:Mercury / Q000032:analysis*; D011807:Quinolizines / Q000737:chemistry*
C553798:9-(2-(1,4-dioxa-7,13-dithia-10-azacyclopentadecyl)phenyl)amino-benzo(b)quinolizinium; D043844:Crown Ethers; D007364:Intercalating Agents; D011807:Quinolizines; D004247:DNA; D008628:Mercury