title: Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring.
abstract: High S(N)2' selectivity in the allylic substitution of cyclohexylidene ethyl picolinates with copper reagents prepared from RMgBr and CuBr.Me(2)S was realized by addition of ZnX(2) (X = I, Br, Cl). Furthermore, ZnX(2) accelerated the reaction with the bulky iPr reagent.
authors.affiliation: Department of Biomolecular Engineering, Tokyo Institute of Technology, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kiyotsuka
authors.forename: Hukum P
authors.initials: HP
authors.lastname: Acharya
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D002244:Carbon / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D003510:Cyclohexanes / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry
chemical_list: D003510:Cyclohexanes; D010848:Picolinic Acids; C506365:Cyclohexane; D002244:Carbon; D003300:Copper