title: Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells.
abstract: Telomerase activity in HIV-1-specific CD8(+) T cells from controllers contributes to the maintenance of highly functional cytotoxic T cell responses against HIV-1. Here, we show that high expression of telomerase in controllers is associated with hypermethylation at the distal and hypomethylation at the proximal human telomerase catalytic subunit promoter, whereas HIV-1-specific CD8(+) T cells from progressors showed an inverse pattern with distal promoter hypomethylation and proximal promoter hypermethylation. These data suggest distinct epigenetic signatures in HIV-1-specific T cells in progressors and controllers.
authors.affiliation: Ragon Institute of MGH, Harvard, Massachusetts Institute of Technology, Boston, Massachusetts 02114, USA.
authors.forename: Katie
authors.initials: K
authors.lastname: Williams
authors.forename: Katherine
authors.initials: K
authors.lastname: Seiss
authors.forename: Jill
authors.initials: J
authors.lastname: Beamon
authors.forename: Florencia
authors.initials: F
authors.lastname: Pereyra
authors.forename: Eric S
authors.initials: ES
authors.lastname: Rosenberg
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Xu G
authors.initials: XG
authors.lastname: Yu
authors.forename: Mathias
authors.initials: M
authors.lastname: Lichterfeld
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019098:Telomerase / Q000235:genetics / Q000276:immunology*; D019562:Viral Load
chemical_list: D019098:Telomerase