Photocontrolled compound release system using caged antimicrobial peptide.
A novel photocontrolled compound release system using liposomes and a caged antimicrobial peptide was developed. The caged antimicrobial peptide was activated by UV irradiation, resulting in the formation of pores on the liposome surface to release the contained fluorophores. The compound release could be observed using fluorescence measurements and time-lapse fluorescence microscopy. UV irradiation resulted in a quick release of the inclusion compounds (within 1 min in most cases) under simulated physiological conditions. The proposed system is expected to be applicable in a wide range of fields from cell biology to clinical sciences.
Mizukami
Shin
S
Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan.
Hosoda
Mariko
M
Satake
Takafumi
T
Okada
Satoshi
S
Hori
Yuichiro
Y
Furuta
Toshiaki
T
Kikuchi
Kazuya
K
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D010455:Peptides / Q000008:administration & dosage*; D010777:Photochemistry; D014466:Ultraviolet Rays
D000890:Anti-Infective Agents; D010455:Peptides