Prolonged neuromuscular blockade following succinylcholine administration to a patient with a reduced butyrylcholinesterase activity.
This case is about a 48-year-old woman known with a reduced butyrylcholinesterase activity, who developed prolonged neuromuscular blockade following the unintentional administration of succinylcholine. We took the opportunity to monitor the development of neuromuscular function during this period and blood samples were taken for molecular genetic analysis and for quantitative and qualitative analysis since not all causative mutations are functionally characterized. Reduced butyrylcholinesterase activity is discussed in many aspects. Clinical considerations are suggested concerning genetic counselling.
Panhuizen
Ivo F
IF
Department for Anaesthesiology, Canisius-Wilhelmina Hospital, C40-01 Postbus 9015, 6500 GS Nijmegen, The Netherlands.
Snoeck
Marc M J
MM
Levano
Soledad
S
Girard
Thierry
T