title: Sensory alien hand syndrome in corticobasal degeneration: a cerebral blood flow study.
abstract: The presence of alien hand syndrome (AHS) is suggestive of the diagnosis of corticobasal degeneration when it develops in a progressive way. Sensory AHS (sAHS) should be distinguished from the motor form described more commonly. The physiopathology of sAHS remains unclear. The aim of this study is to determine cerebral regions involved in sAHS. We compared perfusion single photon emission computer tomography scans of patients with sAHS (n = 3) and without (n = 4). We observed significant decrease of regional cerebral blood flow over the nondominant thalamus in sAHS+ compared to sAHS- patients. This result suggests the involvement of the nondominant thalamus in sAHS.
authors.affiliation: Alzheimer's Disease Clinical Research Centre, Gérontopôle, Toulouse University Hospital, Toulouse, France. delrieu.j@chu-toulouse.fr
authors.forename: Julien
authors.initials: J
authors.lastname: Delrieu
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
authors.forename: Olivier
authors.initials: O
authors.lastname: Toulza
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Esquerre
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Thierry
authors.initials: T
authors.lastname: Voisin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006225:Hand / Q000503:physiopathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D019636:Neurodegenerative Diseases / Q000150:complications*; D012678:Sensation Disorders / Q000209:etiology* / Q000473:pathology*; D014055:Tomography, Emission-Computed / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods