title: Serum prohepcidin levels in children with solid tumors, inflammatory bowel disease and iron deficiency anemia.
abstract: BACKGROUND
  Prohepcidin is one of the regulators of iron metabolism. Few studies examined its relation with solid tumors (ST), inflammatory bowel disease (IBD) and iron deficiency anemia (IDA) in children.
  
  
  METHODS
  We measured serum prohepcidin (SP), soluble transferrin receptor (sTfR), serum ferritin (SF), serum iron (SI), transferrin saturation (TS), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels in ST (n = 16), IBD (n = 15), IDA (n = 14) and controls (n = 18).
  
  
  RESULTS
  The mean SP was significantly higher in ST and IBD than in IDA and controls. SP was significantly correlated with SF in ST, IBD and ESR for IBD and CRP for ST and hemoglobin for ST.
  
  
  CONCLUSIONS
  Elevated SP may be a clinically important predictor of inflammation and leads to anemia by impairing iron utilization in IBD and ST. SP decreases in IDA and is correlated with TS but not with SF or sTfR.
authors.affiliation: Pediatric Hematology Unit, Gazi University. zuhrekaya@gazi.edu.tr
authors.forename: Zühre
authors.initials: Z
authors.lastname: Kaya
authors.forename: Ejderhan
authors.initials: E
authors.lastname: Yildiz
authors.forename: Turkiz
authors.initials: T
authors.lastname: Gursel
authors.forename: Meryem
authors.initials: M
authors.lastname: Albayrak
authors.forename: Ulker
authors.initials: U
authors.lastname: Kocak
authors.forename: Ceyda
authors.initials: C
authors.lastname: Karadeniz
authors.forename: Buket
authors.initials: B
authors.lastname: Dalgiç
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D009369:Neoplasms / Q000150:complications*; D011498:Protein Precursors / Q000097:blood*; D011990:Receptors, Transferrin / Q000097:blood*; D014168:Transferrin / Q000032:analysis
chemical_list: D023181:Antimicrobial Cationic Peptides; D064451:Hepcidins; D011498:Protein Precursors; D011990:Receptors, Transferrin; D014168:Transferrin; D002097:C-Reactive Protein; D005293:Ferritins