The immunogenicity of therapeutic proteins.
Nearly all therapeutic proteins induce antibodies in patients. However this immunogenicity has been neglected in the use of these products, even though the antibodies may have severe consequences. During the last few years, progress has been made in understanding why patients do not tolerate these protein therapeutic products and also how to manage the problem of immunogenicity.
Schellekens
Huub
H
Department of Pharmaceutical Sciences and Department of Innovation Studies, Utrecht University, Rotterdam, Netherlands. h.schellekens@uu.nl
D000818:Animals; D000917:Antibody Formation; D007108:Immune Tolerance; D051379:Mice; D011994:Recombinant Proteins / Q000276:immunology / Q000627:therapeutic use*
D011994:Recombinant Proteins