Third generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA-interaction approach.
The copper(II) complexes of the type [Cu(SPF)(A(n))Cl]/[Cu(PFL)(A(n))Cl] (where SPF is sparfloxacin, PFL is pefloxacin and A(n) is 2,2'-dipyridylamine/pyridine-2-carboxalehyde/thiophene-2-carboxaldehyde) were synthesised and were found to have a pyramidal geometry with a square base. The superoxide dismutase (SOD) like activity of the complexes were measured using an NBT/NADH/PMS system, these were expressed in terms of the concentration of complex which termianates the formation of formazan by 50% (IC₅₀ value) and found to range from 0.781 to 1.354 μM. The interactions of the complexes with DNA were studied by absorption titration, viscosity measurement and gel electrophoresis under physiological conditions. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity.
Patel
Mohan N
MN
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. jeenen@gmail.com
Parmar
Pradhuman A
PA
Gandhi
Deepen S
DS
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D024841:Fluoroquinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015366:Pefloxacin / Q000138:chemical synthesis / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry
D000447:Aldehydes; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D008024:Ligands; D009942:Organometallic Compounds; D013876:Thiophenes; D015366:Pefloxacin; D015082:2,2'-Dipyridyl; D003300:Copper; D004247:DNA; D013482:Superoxide Dismutase; C509177:thiophene-2-carboxaldehyde; C061363:sparfloxacin; C048062:2,2'-dipyridylamine