Bioresorbable electrospun fibers for immobilization of thiol-containing compounds.
For the reconstruction of functional tissue, biodegradable scaffolds providing specific surface functionality and a three-dimensional structure matching that of the damaged tissue are needed. Fibers capable of controlling cell-fiber interaction were produced by electrospinning of PDLLA-block-PEG with thiol-reactive end groups from a solvent mixture. The hydrophilic fibers uniquely combine minimized non-specific protein adsorption and well-defined surface reactivity allowing controlled immobilization of peptides and proteins. Human dermal fibroblasts show adherence and proliferation on the surface of RGDC-functionalized electrospun PDLLA-block-PEG fibers.
Lösel
Robert
R
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e. V., Pauwelsstraße 8, Aachen, Germany.
Grafahrend
Dirk
D
Möller
Martin
M
Klee
Doris
D
D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002478:Cells, Cultured; D055664:Electrochemical Techniques / Q000379:methods*; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry
D001672:Biocompatible Materials; D011108:Polymers; D013438:Sulfhydryl Compounds