title: Tigecycline treatment of multi-drug-resistant Corynebacterium jeikeium infection in a child with relapsing and refractory acute lymphoblastic leukemia.
abstract: Corynebacterium jeikeium has been recognized as an important cause of infection, particularly among neutropenic patients who have central venous catheter (CVC). Routine use of tigecycline in children is not yet approved. Here in we present a child with relapsed-refractory lymphoblastic leukemia who was successfully treated with tigecyline due to multi-drug-resistant C. jeikeium sepsis without removal of CVC. Our case highlights the use of tigecycline where there are no alternatives. Further studies regarding the efficacy and safety of tigecycline in pediatric patients are needed.
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Eskisehir Osmangazi University, Eskisehir, Turkey. timboothtr@yahoo.com
authors.forename: Ener Cagri
authors.initials: EC
authors.lastname: Dinleyici
authors.forename: Zeynel Abidin
authors.initials: ZA
authors.lastname: Yargic
authors.forename: Ozcan
authors.initials: O
authors.lastname: Bor
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Kiremitci
authors.forename: Gul
authors.initials: G
authors.lastname: Durmaz
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D055499:Catheter-Related Infections; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D003354:Corynebacterium Infections / Q000188:drug therapy*; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology; D012008:Recurrence; D012074:Remission Induction; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline