[Photobiochemistry of folates: a photochemical reduction of folic acid].
Exposure of deaerated folic acid solutions containing an electron donor to UV radiation (310-390 nm, I = 0.4 W m(-2)) induced formation of dihydrofolic acid (DHFA), a photoexcitation which gave tetrahydrofolic acid (THFA). Only DHFA was formed in the presence of EDTA (E'o = +0.40 V), while the presence of stronger reductants-NADH (E'o = -0.32 V) and boron hydride (E'o = -0.48 V)-induced photoreduction to THFA. It was demonstrated that UV radiation had no effect on the THFA formylation, giving the coenzyme 5,10-methenyltetrahydrofolic acid and its transformation into another coenzyme, 5-formyltetrahydrofolic acid.
Vechtomova
Iu L
IuL
Telegina
T A
TA
Kolesnikov
M P
MP
Kritskiĭ
M S
MS
D004492:Edetic Acid / Q000737:chemistry*; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D055668:Photochemical Processes; D013763:Tetrahydrofolates / Q000737:chemistry*; D014466:Ultraviolet Rays
D013763:Tetrahydrofolates; C010920:dihydrofolate; C030371:5,6,7,8-tetrahydrofolic acid; D005492:Folic Acid; D004492:Edetic Acid