Plasma cell-rich acute rejection after renal transplantation in a patient with pyoderma gangrenosum: a case report.
A 40-yr-old female received a living-related renal transplantation on January 29, 2008. She had type I diabetes mellitus and pyoderma gangrenosum (PG). Induction immunosuppressive therapy consisted of tacrolimus, mycophenolate mofetil, basiliximab, and prednisolone. Intravenous methylprednisolone pulse therapy was administered to prevent ulceration at the surgical site. The postoperative outcome was almost uneventful, and renal graft function was well preserved for 11 months. Her graft function deteriorated on December 24, 2008 and thus an episode biopsy was performed. The histopathological findings were consistent with plasma cell-rich acute rejection (PCAR). During hospitalization, it was noted that the patient was non-compliant. We then performed steroid pulse therapy, and her graft function and histological findings improved. This is the first report of PCAR in a patient with PG who received a renal allograft. It was thought that PCAR was triggered because of her non-compliance. Thus, we should recognize the importance of enhancing compliance in transplant recipients.
Horie
Katsunori
K
Department of Nephrology and Dialysis Therapy, Chukyo Hospital, 1-1-10 Sanjou Minami-ku, Nagoya, Japan. khorie@kb3.so-net.ne.jp
Fujita
Takashi
T
Tsuyuki
Mikito
M
Nishio
Fumitoshi
F
Watanabe
Tatsuaki
T
Kanou
Yasuko
Y
Kuzuya
Akihiko
A
Sato
Motoyoshi
M
Kinukawa
Tsuneo
T
D000208:Acute Disease; D000328:Adult; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D019520:Living Donors; D008775:Methylprednisolone / Q000627:therapeutic use; D010950:Plasma Cells / Q000276:immunology*; D020551:Pulse Therapy, Drug; D017511:Pyoderma Gangrenosum / Q000150:complications*
D007166:Immunosuppressive Agents; D003404:Creatinine; D008775:Methylprednisolone