title: An infant with subdural hematoma and retinal hemorrhages: does von Willebrand disease explain the findings?
abstract: An 11-month-old girl presented to hospital with a massive subdural haematoma and bilateral retinal haemorrhages following an allegedly minor fall. There were no external signs of bruising and no prior bleeding tendency was reported. Although initial analyses were normal, repeated testing of the coagulation-fibrinolysis system led to a diagnosis of mild von Willebrand disease (vWD) Type 1. It was concluded that minor head trauma as described by the parents, in the presence of such a coagulation disorder, could explain the findings. Police charges against the parents, initially accused of child abuse, were withdrawn. Retinal haemorrhages in infants with vWD have not been previously reported. This case highlights the importance of considering vWD as a possible contributory factor in cases of infant head injury.
authors.affiliation: Division of Pathology, Oslo University, University of Oslo, Rikshospitalet, Oslo, Norway. arne.stray-pedersen@medisin.uio.no
authors.forename: Arne
authors.initials: A
authors.lastname: Stray-Pedersen
authors.forename: Sigrid
authors.initials: S
authors.lastname: Omland
authors.forename: Bård
authors.initials: B
authors.lastname: Nedregaard
authors.forename: Sjur
authors.initials: S
authors.lastname: Klevberg
authors.forename: Torleiv Ole
authors.initials: TO
authors.lastname: Rognum
mesh_terms: D000058:Accidental Falls; D001344:Autopsy; D001779:Blood Coagulation Factors / Q000378:metabolism; D002649:Child Abuse / Q000175:diagnosis / Q000331:legislation & jurisprudence; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D049429:Forensic Pathology; D006408:Hematoma, Subdural / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007223:Infant; D012166:Retinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology*; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications*
chemical_list: D001779:Blood Coagulation Factors