Spontaneous recovery from progressive multifocal leukoencephalopathy in a patient with non-active sarcoidosis.
We report the case of a 50-year-old female patient with non-active sarcoidosis and no kind of immunosuppression, admitted to our hospital because of increasing confusion and focal neurological deficits. Initially a tumor, herpes encephalitis, or neurosarcoidosis were suspected, but surprisingly biopsy revealed progressive multifocal leukoencephalopathy, additionally confirmed by JC-positive PCR in cerebrospinal fluid. Cases of sarcoidosis and progressive multifocal leukoencephalopathy have been reported before. This is the first case of a patient with no sign of active sarcoidosis and without immunosuppressive therapy who recovered spontaneously with a follow-up time of nearly 3 years.
Goldbecker
Annemarie
A
Department of Neurology and Neurophysiology, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, Germany. goldbecker.annemarie@mh-hannover.de
Tountopoulou
Argyro
A
Wurster
Ulrich
U
Donnerstag
Frank
F
Brandis
Almuth
A
Bonnemann
Catharina
C
Weissenborn
Karin
K
D001569:Benzodiazepines / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D000077152:Olanzapine; D012075:Remission, Spontaneous; D012507:Sarcoidosis / Q000150:complications*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D001569:Benzodiazepines; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors