title: Structure-function relationships in normal and glaucomatous eyes determined by time- and spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  To compare the relationships between retinal mean sensitivity (MS) and retinal nerve fiber layer (RNFL) thickness, as measured by time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT).
  
  
  METHODS
  Recruited subjects were divided into normal, glaucoma suspect, and glaucoma groups. RNFL thickness was measured with TD- and SD-OCT, and MS was assessed with visual field perimetry and expressed in decibels and 1/L, where L is luminance in lamberts. The relationship between SUPERIOR MS and INFERIOR RNFL thickness (clock-hour segments 5, 6, 7, and 8) and that between INFERIOR MS and SUPERIOR RNFL thickness (clock-hour segments 10, 11, 12, 1, 2, and 3) were correlated by linear and logarithmic regression analyses. Pearson's correlation coefficients (R), for both OCTs were compared by using Hotelling's t-test.
  
  
  RESULTS
  Ninety-five eyes of 76 subjects were prospectively included. Twenty-five eyes were classified as normal, 25 with glaucoma suspect, and 45 with glaucoma. In normal and glaucoma suspect eyes, there were no significant relationships between MS and RNFL thickness. In glaucomatous eyes, the associations between MS and RNFL thickness were R = 0.31 to 0.57 with TD-OCT and R = 0.47 to 0.66 with SD-OCT, and the correlation of SUPERIOR RNFL thickness with INFERIOR MS was significantly better with SD-OCT than with TD-OCT in both linear and logarithmic regression models.
  
  
  CONCLUSIONS
  The results showed that, in mild-to-moderate glaucoma, SD-OCT offers an improved structure-function correlation compared with TD-OCT, when applied to the detection of INFERIOR MS and SUPERIOR RNFL defects.
authors.affiliation: HanGil Eye Hospital, Bupyeong-gu, Incheon, Republic of Korea.
authors.forename: Jong Rak
authors.initials: JR
authors.lastname: Lee
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Jeoung
authors.forename: Jaewan
authors.initials: J
authors.lastname: Choi
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Yeon-deok
authors.initials: YD
authors.lastname: Kim
mesh_terms: D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000503:physiopathology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology