title: Paroxysmal EEG abnormalities and epilepsy in pervasive developmental disorders: follow-up study until adolescence and beyond.
abstract: This study examined paroxysmal abnormalities and epilepsy in EEG for individuals with pervasive developmental disorders (PDD) in two parts: first with a large number of subjects (n=1624); and second with extracted subjects followed from 5 years into adolescence and beyond (n=92). Many paroxysms in PDD patients in their childhood tended to appear at various sites and the same held for paroxysms at the time of epilepsy onset. However, in adolescence and beyond, paroxysms in the frontal region prevailed as those appearing at sites other than the frontal region tended to disappear. The same held for paroxysms at the time of epilepsy onset. These paroxysms in the frontal area characteristic of PDD were named "Paroxysms at F." It was suggested that functional abnormality in the frontal region exists in PDD through paroxysmal EEG abnormalities and epilepsy.
authors.affiliation: Musasino Child Development Clinic, 12-1 Nukuikita 4 Chome, Koganei City, Tokyo, Japan. y-kawasaki@extra.ocn.ne.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Mieko
authors.initials: M
authors.lastname: Shinomiya
authors.forename: Mizuho
authors.initials: M
authors.lastname: Takayanagi
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Niwa
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000473:pathology / Q000503:physiopathology*; D002675:Child, Preschool; D018450:Disease Progression; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D055815:Young Adult