title: Updates of adjuvant therapy in pancreatic cancer: where are we and where are we going? Highlights from the "2010 ASCO Annual Meeting". Chicago, IL, USA. June 4-8, 2010.
abstract: Pancreatic cancer represents the 4th leading cause of cancer deaths in the United States. Surgical resection remains the only potential curative approach. Current standard adjuvant therapy is gemcitabine monotherapy for 6 months. This year several trials investigated other combinations with or without molecular target agents, with or without concurrent radiation attempting to optimize adjuvant therapy. Several abstracts presented at the 2010 American Society of Clinical Oncology (ASCO) Annual Meeting are highlighted here and will be further discussed in this review article. Abstracts #4012, #4059, and TPS226 added immunotherapy to adjuvant treatment. Abstract #4034 demonstrated lack of efficacy by adding either cetuximab or bevacizumab to known adjuvant therapies. Abstract e14625 combined S-1 to gemcitabine and abstract #4113 demonstrated a positive correlation between symptoms and CA 19-9 levels with the length of survival.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Man Yee
authors.initials: MY
authors.lastname: Merl
authors.forename: John
authors.initials: J
authors.lastname: Chabot
authors.forename: Muhammad Wasif
authors.initials: MW
authors.lastname: Saif
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D002277:Carcinoma / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D002641:Chicago; D003131:Combined Modality Therapy / Q000379:methods / Q000639:trends*; D003226:Congresses as Topic; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008495:Medical Oncology / Q000639:trends; D010190:Pancreatic Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012955:Societies, Medical; D014481:United States
chemical_list: D000276:Adjuvants, Immunologic