title: Cocaethylene: effects on brain systems and behavior.
abstract: Cocaethylene is a psychoactive metabolite formed during the combined consumption of cocaine and ethanol. In this brief review, we discuss several well-characterized effects of this metabolite with an emphasis on the neurobiological and behavioral correlates of polydrug addiction. Included herein are the descriptions of some of the changes in trans-synaptic transmission and their relationship to pathological behaviors associated with a chronic, drug-dependent state that may be altered by the spatial or temporal dynamics of cocaethylene.
authors.affiliation: Medaille College, Department of Social Sciences, Agassiz Circle, Buffalo, New York.
authors.forename: J M
authors.initials: JM
authors.lastname: Horowitz
authors.forename: G
authors.initials: G
authors.lastname: Torres