Enantioselective synthesis of highly functionalised amides by copper-catalysed vinylogous Mukaiyama aldol reaction.
Amides with quaternary stereogenic centers have been synthesised by catalytic asymmetric vinylogous Mukaiyama aldol reactions. The chiral copper-sulfoximine catalyst gives rise to products with moderate to good yields and up to 92% ee.
Frings
Marcus
M
Institute of Organic Chemistry RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.
Goedert
Daniel
D
Bolm
Carsten
C
D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D000577:Amides; D003300:Copper; C116609:3-hydroxybutanal