Possible effects of some antipsychotic drugs on C-reactive protein in a drug-naïve psychotic sample.
Antipsychotic effects on C-reactive protein (CRP) have received little attention. This randomized open-label study investigated the possible effects of antipsychotics on CRP levels after 3 and 12 months of treatment in a Spanish drug-naïve sample taking haloperidol (N=36 after 3 months), olanzapine (N=36 after 3 months) or risperidone (N=39 after 3 months). After 3 months and adjusting for differences in baseline CRP levels, baseline smoking and high baseline triglyceride levels, patients on haloperidol treatment had CRP levels that were 92.7% higher than those of patients on risperidone treatment (p=0.009). After 12 months, only smoking was associated with increased CRP levels. Future studies need to verify that different antipsychotics may have differential effects on CRP levels, particularly after 3 months of treatment.
Diaz
Francisco J
FJ
Department of Biostatistics, The University of Kansas Medical Center, Kansas City, KS, United States.
Pérez-Iglesias
Rocío
R
Mata
Ignacio
I
Martínez-Garcia
Obdulia
O
Vázquez-Barquero
José L
JL
de Leon
Jose
J
Crespo-Facorro
Benedicto
B
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D004311:Double-Blind Method; D006801:Humans; D007118:Immunoassay / Q000379:methods; D016014:Linear Models; D008075:Lipoproteins, HDL / Q000378:metabolism; D008137:Longitudinal Studies; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000378:metabolism*; D013997:Time Factors
D014150:Antipsychotic Agents; D008075:Lipoproteins, HDL; D002097:C-Reactive Protein