title: Synthesis of polyhalo acridones as pH-sensitive fluorescence probes.
abstract: Polyhalo isophthalonitriles were reacted with substituted anilines and subsequently cyclocondensed in the presence of sulfuric acid to give polyhalo acridones. These polyhalo acridones were proven to be useful as pH-sensitive fluorescent probes for a wide range of acidic and basic conditions.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.forename: Sheng-Jiao
authors.initials: SJ
authors.lastname: Yan
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D054831:Acridones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D013464:Sulfuric Acids / Q000737:chemistry
chemical_list: D054831:Acridones; D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D013464:Sulfuric Acids; C033158:sulfuric acid