[Tigecycline: in vitro antimicrobial activity in hospitalized patients in an infectology hospital].
OBJECTIVE
TO evaluate the antimicrobial in vitro tigecycline activity at a infectious disease hospital.


METHODS
Using plaque microdilution technique for 20 different antimicrobials, the antimicrobial susceptibility percentages and minimum inhibitory concentrations (MIC) were determined form 135 Gram-negative and 65 Gram-positive organisms obtained from severely infected hospitalized patients of both genders and any age.


RESULTS
Tigecycline showed a good antimicrobial activity and MIC 50- and 90-fold lower of all antibiotics assessed for isolated microorganisms, including methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, as well as for microorganisms in the enterobacteriaceae family and Acinetobacter baumanii.


CONCLUSIONS
The extensive use of antimicrobial, disinfectants and antiseptics in the hospital setting have developed elevated antimicrobial resistance levels. Tigecycline could be an initial therapeutic alternative against Gram-positive and Gram-negative microorganisms, including multi-resistant nosocomial pathogens, such as Acinetobacter baumanii and methicillin-resistant Staphylococcus aureus, in intra-abdominal, skin and skin structure infections and in community-acquired pneumonia.
Barriga-Angulo
Gustavo
G
Laboratorio de Microbiología, Hospital de Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal, México. gustavo.barriga@imss.gob.mx
Osorio-Carranza
María de Lourdes
Mde L
Sánchez-Hernández
Eva Aurora
EA
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D005260:Female; D006760:Hospitalization; D006782:Hospitals, Special; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline