Excitation-contraction coupling and minor triadic proteins in low-frequency fatigue.
Low-frequency fatigue (LFF) is characterized by a proportionally greater loss of force at low compared with high activation frequencies and a prolonged recovery. Recent work suggests a calcium-induced uncoupling of excitation-contraction coupling underlies LFF. Here, newly characterized triadic proteins are described, and possible mechanisms by which they may contribute to LFF are suggested.
Balog
Edward M
EM
School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA 30332, United States. ed.balog@ap.gatech.edu
D000818:Animals; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology; D056966:Excitation Contraction Coupling / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D009124:Muscle Proteins / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000502:physiology
D015220:Calcium Channels; D008565:Membrane Proteins; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium