title: First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial.
abstract: BACKGROUND
  Org 25435 is a new water-soluble alpha-amino acid ester intravenous anaesthetic which proved satisfactory in animal studies. This study aimed to assess the safety, tolerability and efficacy of Org 25435 and to obtain preliminary pharmacodynamic and pharmacokinetic data.
  
  
  METHODS
  In the Short Infusion study 8 healthy male volunteers received a 1 minute infusion of 0.25, 0.5, 1.0, or 2.0 mg/kg (n = 2 per group); a further 10 received 3.0 mg/kg (n = 5) or 4.0 mg/kg (n = 5). Following preliminary pharmacokinetic modelling 7 subjects received a titrated 30 minute Target Controlled Infusion (TCI), total dose 5.8-20 mg/kg.
  
  
  RESULTS
  Within the Short Infusion study, all subjects were successfully anaesthetised at 3 and 4 mg/kg. Within the TCI study 5 subjects were anaesthetised and 2 showed signs of sedation. Org 25435 caused hypotension and tachycardia at doses over 2 mg/kg. Recovery from anaesthesia after a 30 min administration of Org 25435 was slow (13.7 min). Pharmacokinetic modelling suggests that the context sensitive half-time of Org 25435 is slightly shorter than that of propofol in infusions up to 20 minutes but progressively longer thereafter.
  
  
  CONCLUSIONS
  Org 25435 is an effective intravenous anaesthetic in man at doses of 3 and 4 mg/kg given over 1 minute. Longer infusions can maintain anaesthesia but recovery is slow. Hypotension and tachycardia during anaesthesia and slow recovery of consciousness after cessation of drug administration suggest this compound has no advantages over currently available intravenous anaesthetics.
authors.affiliation: Peninsula College of Medicine & Dentistry, University of Plymouth, The John Bull Building, Research Way, Tamar Science Park, Plymouth PL6 8BU, UK. robert.sneyd@pms.ac.uk.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Rigby-Jones
authors.forename: J Robert
authors.initials: JR
authors.lastname: Sneyd
authors.forename: Peter
authors.initials: P
authors.lastname: Vijn
authors.forename: Patrick
authors.initials: P
authors.lastname: Boen
authors.forename: Maurice
authors.initials: M
authors.lastname: Cross