title: The Aspergillus niger RmsA protein: A node in a genetic network?
abstract: Many cells and organisms go through polarized growth phases during their life. Cell polarization is achieved by local accumulation of signaling molecules which guide the cytoskeleton and vesicular trafficking to specific parts of the cell and thus ensure polarity establishment and maintenance. Polarization of signaling molecules is also fundamental for the lifestyle of filamentous fungi such as Aspergillus niger and essential for their morphogenesis, development and survival under environmental stress conditions. Considerable advances in our understanding on the protagonists and processes mediating polarized growth in filamentous fungi have been made over the past years. However, how the interplay of different signaling pathways is coordinated has yet to be determined. We found that the A. niger RmsA protein is central for the polarization of actin at the hyphal tip but also of vital importance for the metabolism, viability and stress resistance of A. niger. This suggests that RmsA could occupy an important position in the global network of pathways that balance growth, morphogenesis and survival of A. niger.
authors.affiliation: Leiden University; Institute of Biology Leiden; Department Molecular Microbiology and Biotechnology; BE Leiden, The Netherlands.
authors.forename: Vera
authors.initials: V
authors.lastname: Meyer
authors.forename: Susann
authors.initials: S
authors.lastname: Minkwitz
authors.forename: Tabea
authors.initials: T
authors.lastname: Schütze
authors.forename: Cees A M J J
authors.initials: CA
authors.lastname: van den Hondel
authors.forename: Arthur F J
authors.initials: AF
authors.lastname: Ram