title: Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia.
abstract: Dioxins, furans, and polychlorinated biphenyls (PCBs) are persistent and bioaccumulative toxic chemicals that are ubiquitous in the environment. We assessed predictors of their serum concentrations among women living in a Russian town contaminated by past industrial activity. Blood samples from 446 mothers aged 23-52 years were collected between 2003-2005 as part of the Russian Children's Study. Serum dioxin, furan, and PCB concentrations were quantified using high-resolution gas chromatography-mass spectrometry. Potential determinants of exposure were collected through interviews. Multivariate linear regression models were used to identify predictors of serum concentrations and toxic equivalencies (TEQs). The median total PCB concentrations and total TEQs were 260 ng/g lipid and 25 pg TEQ/g lipid, respectively. In multivariate analyses, both total PCB concentrations and total TEQs increased significantly with age, residential proximity to a local chemical plant, duration of local farming, and consumption of local beef. Both decreased with longer breastfeeding, recent increases in body mass index, and later blood draw date. These demographic and lifestyle predictors showed generally similar associations with the various measures of serum dioxins, furans, and PCBs.
authors.affiliation: Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Humblet
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.forename: Susan A
authors.initials: SA
authors.lastname: Korrick
authors.forename: Oleg
authors.initials: O
authors.lastname: Sergeyev
authors.forename: Claude
authors.initials: C
authors.lastname: Emond
authors.forename: Linda S
authors.initials: LS
authors.lastname: Birnbaum
authors.forename: Jane S
authors.initials: JS
authors.lastname: Burns
authors.forename: Larisa
authors.initials: L
authors.lastname: Altshul
authors.forename: Donald G
authors.initials: DG
authors.lastname: Patterson
authors.forename: Wayman E
authors.initials: WE
authors.lastname: Turner
authors.forename: Mary M
authors.initials: MM
authors.lastname: Lee
authors.forename: Boris
authors.initials: B
authors.lastname: Revich
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
mesh_terms: D000328:Adult; D000375:Aging; D004147:Dioxins / Q000097:blood*; D004785:Environmental Pollutants / Q000737:chemistry*; D005260:Female; D005663:Furans / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011078:Polychlorinated Biphenyls / Q000097:blood*; D012426:Russia; D055815:Young Adult
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants; D005663:Furans; D011078:Polychlorinated Biphenyls