[Correlation between the phenotype and genotype of tooth agenesis patients by tooth agenesis code].
OBJECTIVE
To analyze the correlation between the phenotype and genotype of tooth agenesis using the tooth agenesis code (TAC) and the traditional descriptor for missing teeth.


METHODS
Patients with isolated hypodontia caused by PAX9 or MSX1 mutation reported before May 2007 were enrolled. The teeth missing rate and TAC code were recorded. The missing teeth patterns caused by the two mutations were compared.


RESULTS
The teeth missing rates in each teeth positions were significantly different between maxillary and mandibular except maxillary central incisor, lateral incisor and mandibular canine, first molar (P<0.05, P<0.001). MSX1 gene mutation often led to the loss of maxillary first premolar, maxillary second premolar, and mandibular second premolar, while PAX9 gene mutation often led to the loss of the first, second, and third molars. The results were similar when analyzed either by TAC code analysis or by traditional descriptor.


CONCLUSIONS
PAX9 and MSX1 gene mutation can cause different phenotypes of tooth agenesis. The TAC code can be used in the analysis of the correlation between phenotype and genotype of the missing teeth patients.
Gong
Yu
Y
Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China. kqfenghl@bjmu.edu.cn
Feng
Hai-Lian
HL
He
Hui-Ying
HY
Ge
Yan-Jun
YJ
D000848:Anodontia / Q000235:genetics*; D005838:Genotype; D006801:Humans; D051957:MSX1 Transcription Factor / Q000235:genetics*; D009154:Mutation; D051764:PAX9 Transcription Factor / Q000235:genetics*; D010641:Phenotype
D051957:MSX1 Transcription Factor; C484083:MSX1 protein, human; D051764:PAX9 Transcription Factor; C497323:PAX9 protein, human