A highly convergent synthesis of tricyclic N-heterocycles coupling an Ugi reaction with a tandem S(N)2'-Heck double cyclization.
A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a S(N)2' cyclization followed by an intramolecular Heck reaction.
Riva
Renata
R
Dipartimento di Chimica e Chimica Industriale, Via Docecaneso 31, 16146 Genova, Italy. riva@chimica.unige.it
Banfi
Luca
L
Basso
Andrea
A
Cerulli
Valentina
V
Guanti
Giuseppe
G
Pani
Marcella
M
D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D006571:Heterocyclic Compounds