title: Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds.
abstract: In this paper, we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e. fast B scan mode is used to achieve the capillary flow imaging. We employ a 1310nm system to scan the skin tissue at an imaging rate of 300 frames per second, which requires only ~5 sec to complete one 3D imaging of capillary blood flow within skin. The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases.
authors.affiliation: Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97237, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.forename: Jia
authors.initials: J
authors.lastname: Qin
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000792:Angiography / Q000379:methods*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D012867:Skin / Q000033:anatomy & histology / Q000098:blood supply*