title: Fresh-frozen plasma transfusion strategy in trauma with massive and ongoing bleeding. Common (sense) and sensibility.
abstract: During trauma resuscitation involving massive transfusion, the best fresh-frozen plasma to packed red blood cells ratio is unknown. No randomised controlled trial (RCT) is available on this subject, although there are plenty of observational studies suggesting that the ratio should be about 1:1. This ratio also makes more physiological sense, and we suggest that in patients with massive and ongoing bleeding, it is a sensible strategy with which to start resuscitation.
authors.affiliation: Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. hoamh@hotmail.com
authors.forename: Anthony M-H
authors.initials: AM
authors.lastname: Ho
authors.forename: Peter W
authors.initials: PW
authors.lastname: Dion
authors.forename: Janice H H
authors.initials: JH
authors.lastname: Yeung
authors.forename: Calvin S H
authors.initials: CS
authors.lastname: Ng
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Karmakar
authors.forename: Lester A H
authors.initials: LA
authors.lastname: Critchley
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Rainer
authors.forename: Chi Wai
authors.initials: CW
authors.lastname: Cheung
authors.forename: Beng A
authors.initials: BA
authors.lastname: Tay
mesh_terms: D016913:Blood Component Transfusion / Q000592:standards*; D017707:Erythrocyte Transfusion; D006470:Hemorrhage / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D010949:Plasma; D012151:Resuscitation / Q000379:methods*; D012720:Severity of Illness Index; D014947:Wounds and Injuries / Q000150:complications* / Q000503:physiopathology*