Onionin A from Allium cepa inhibits macrophage activation.
Onionin A (1), a new, stable, sulfur-containing compound, was isolated from acetone extracts of bulbs of onion (Allium cepa), and its structure was characterized as 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophen-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis. This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages.
El-Aasr
Mona
M
Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.
Fujiwara
Yukio
Y
Takeya
Motohiro
M
Ikeda
Tsuyoshi
T
Tsukamoto
Sachiko
S
Ono
Masateru
M
Nakano
Daisuke
D
Okawa
Masafumi
M
Kinjo
Junei
J
Yoshimitsu
Hitoshi
H
Nohara
Toshihiro
T
D000490:Allium / Q000737:chemistry*; D015703:Antigens, CD / Q000187:drug effects; D015214:Antigens, Differentiation, Myelomonocytic / Q000187:drug effects; D006801:Humans; D007564:Japan; D008264:Macrophages / Q000187:drug effects*; D019697:Onions / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000187:drug effects; D013454:Sulfoxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000098902:CD163 Antigen
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; D013454:Sulfoxides; D013876:Thiophenes; C551608:onionin A