Outcome of attempted Hickman catheter salvage in febrile neutropenic cancer patients with Staphylococcus aureus bacteremia.
There are limited data on outcomes of Hickman catheter salvage associated with Staphylococcus aureus bacteremia (SAB) in neutropenic cancer patients. We evaluated the outcome of attempted Hickman catheter salvage in these patients who were not given antibiotic lock therapy. Outcomes were retrospectively analyzed in all neutropenic cancer patients with Hickman catheter-related SAB over a 12-year period (56 episodes in 54 patients). Salvage attempts were defined as cases where the catheter was still in place 3 days after initial bacteremia. Salvage attempts were considered successful if catheter was still in place 12 weeks later without recurrent SAB or death. Of the 56 episodes, catheters were immediately removed in eight (14%), and catheter salvage was attempted in 48 (86%). Of these 48 episodes, attempted salvage was successful in 29 (60%) and failed in 14 (29%). Outcome of attempted salvage was indeterminate in five (11%) episodes. In univariate analysis, presence of external signs of catheter infection (p = 0.03), positive follow-up blood culture (p = 0.03), and methicillin resistance (p = 0.04) were significantly associated with catheter salvage failure. In multivariate analysis, presence of external signs of catheter infection (OR 12.0; p = 0.04) and methicillin resistance (OR 5.1; p = 0.04) were independently associated with catheter savage failure. In conclusion, attempted catheter salvage without antibiotic lock therapy was successful in 60% of the patients with Hickman catheter-related SAB. External signs of catheter infection and methicillin resistance were independent risk factors for catheter salvage failure.
Park
Ki-Ho
KH
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, Republic of Korea.
Cho
Oh-Hyun
OH
Lee
Sang-Oh
SO
Choi
Sang-Ho
SH
Kim
Yang Soo
YS
Woo
Jun Hee
JH
Kim
Mi-Na
MN
Lee
Dae Ho
DH
Suh
Cheolwon
C
Kim
Dae-Young
DY
Lee
Jung-Hee
JH
Lee
Je-Hwan
JH
Lee
Kyoo-Hyung
KH
Kim
Sung-Han
SH
D000293:Adolescent; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D002408:Catheters, Indwelling / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D009503:Neutropenia / Q000503:physiopathology*; D010361:Patients; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D016896:Treatment Outcome; D055815:Young Adult