Amisulpride overdose: suggested management of prolonged QTc.
A case of amisulpride overdose is presented and its effect on prolonging the QT (corrected) interval is discussed. Amisulpride is used for the treatment of schizophrenia and part of its safety profile is that is has no effect on the QT interval in therapeutic doses. The efficacy of intravenous calcium in restoring the QT to normal is proposed.
Stevenson
Richard J
RJ
Accident and Emergency, Monklands District General Hospital, Airdrie ML6 0JS, Lanarkshire, Scotland, UK. richard.stevenson@nhs.net
D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000506:poisoning*; D002118:Calcium / Q000008:administration & dosage; D062787:Drug Overdose / Q000188:drug therapy; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced / Q000188:drug therapy; D007262:Infusions, Intravenous; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000506:poisoning
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride; D002118:Calcium