title: In vitro and in vivo evaluation of Dideco's paediatric cardiopulmonary circuit for neonates weighing less than five kilograms.
abstract: The neonate cardiopulmonary bypass (CPB) circuit, including a KIDS D100 oxygenator (The Sorin Group, Mirandola, Italy) and a D130 arterial filter (The Sorin Group), was evaluated in vitro with respect to the removal of free micro gas bubbles. No gas bubbles > 40microm were measured after the arterial filter D130 upon manual introduction of 10 ml of air into the venous line or during the use of vacuum-assisted venous drainage (VAVD). The D130 arterial filter removed 88 % of gas bubbles < 40 microm during manual introduction of air into the venous line; however, only 50 % of gas bubbles < 40 microm were removed during the use of VAVD. The same CPB circuit was evaluated in vivo to compare with another CPB circuit, including a D901 oxygenator (The Sorin Group) and arterial filter D736 (The Sorin Group), in 155 neonates weighing < or =5 kg. The D100 circuit required significantly less priming volume than the D901 circuit. Postoperative haemoglobin was significantly higher, artificial ventilation time was significantly shorter and postoperative bleeding was significantly less in the D100 group. This neonate CPB circuit effectively removed the gas bubbles and required up to 37% less priming volume and, thus, decreased the need for blood transfusion.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway. amrit.thiara@rikshospitalet.no
authors.forename: A S
authors.initials: AS
authors.lastname: Thiara
authors.forename: V
authors.initials: V
authors.lastname: Eggereide
authors.forename: T
authors.initials: T
authors.lastname: Pedersen
authors.forename: H
authors.initials: H
authors.lastname: Lindberg
authors.forename: A E
authors.initials: AE
authors.lastname: Fiane
mesh_terms: D001835:Body Weight; D002315:Cardiopulmonary Bypass / Q000295:instrumentation* / Q000379:methods*; D004618:Embolism, Air / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D005112:Extracorporeal Circulation / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male