title: How to manage an unresectable or recurrent sialoblastoma.
abstract: Only 2-5% of all salivary gland tumors occur in children. Sialoblastoma is an extremely rare salivary gland tumor diagnosed at birth or shortly thereafter with significant variability in histological range and clinical course, so that it may be difficult to predict the most appropriate therapy. In cases where surgical removal is not curative or technically feasible, chemotherapy may be attempted. We report herein a patient with progression of a huge partially resected sialoblastoma who was successfully treated with chemotherapy. Systemic chemotherapy with vincristine, actinomycin D, and cyclophosphamide (VAC) seems to be an effective adjuvant or neoadjuvant treatment option for unresectable or recurrent sialoblastoma.
authors.affiliation: Department of Pediatric Hematology-Oncology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. ebrusaribeyoglu@gmail.com
authors.forename: Ebru Tugrul
authors.initials: ET
authors.lastname: Saribeyoglu
authors.forename: Omer
authors.initials: O
authors.lastname: Devecioglu
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Karakas
authors.forename: Sema
authors.initials: S
authors.lastname: Anak
authors.forename: Aysegul
authors.initials: A
authors.lastname: Unuvar
authors.forename: Leyla
authors.initials: L
authors.lastname: Agaoglu
authors.forename: Aladdin
authors.initials: A
authors.lastname: Celik
authors.forename: Mine
authors.initials: M
authors.lastname: Gulluoglu
authors.forename: Bilge
authors.initials: B
authors.lastname: Bilgic
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D019468:Disease Management; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D012468:Salivary Gland Neoplasms / Q000151:congenital* / Q000188:drug therapy* / Q000601:surgery; D016879:Salvage Therapy; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide