Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in a patient with peritoneal mesothelioma and HIV infection.
BACKGROUND
High rates of septic complications have been associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, which has been suggested as the treatment of choice for isolated peritoneal malignancies. Patients infected by the human immunodeficiency virus (HIV) are still considered at a high operative risk.


METHODS
A 58-year-old man with HIV infection and diffuse peritoneal mesothelioma underwent optimal cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.


RESULTS
The patient experienced a complete clinical response to therapy with no adverse effect on disease course or markers for HIV (CD4 count, beta2-microglobulin, neopterin, p24 antigen, and viral load).


CONCLUSIONS
This report suggests that this innovative approach can be successfully performed also in this clinical setting. In selected patients who respond to all criteria, surgery is possible and is a safe and effective therapeutic option.
Balestra
Maria Rosaria
MR
Department of Surgery National Cancer Institute, Milan, Italy.
Baratti
Dario
D
Crippa
Fulvio
F
Laterza
Barbara
B
Kusamura
Shigeki
S
Langer
Martin
M
Deraco
Marcello
M
D003131:Combined Modality Therapy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000150:complications / Q000628:therapy*