Examining the relationship between brominated flame retardants (BFR) exposure and changes of thyroid hormone levels around e-waste dismantling sites.
Brominated flame retardants (BFRs) released from e-waste related activities may affect the health of local people. Assessing the impact of e-waste exposure during recycling and dismantling activities on local people's thyroid hormone levels is an area of ongoing research. During November and December 2008, the process of e-waste recycling and dismantling was investigated, and 236 occupation-exposed people and 89 non-occupation-exposed people approximate to the e-waste recycling sites were surveyed; their thyroid hormone levels (THs), thyrotropins (TSH) and BFRs levels in serum were assayed. Multiple regression models were constructed to analyze the changes of serum THs and TSH in the people living in the exposure area (exposure group) and the people in the control group. Covariates known to be or likely to be associated with THs, TSH and BFRs levels were analyzed. Lower level of Triiodothyronine (T(3)) in both occupation-exposed and non-occupation-exposed group were observed (p<0.01), when compared with the control group, and the same trend was obtained for free triiodothyronine (fT(3)) and free thyroxine (fT4) (p<0.01). However, no significant difference in thyroxine (T(4)) was found between the two groups. The level of TSH in the e-waste recycling occupational-exposed group ranged from 0.00 to 5.00microIU/ml with a mean of 1.26microIU/ml, whereas the level of TSH in the control group was from 0.03 to 5.54microIU/ml with a mean of 1.57microIU/ml. This study revealed that people having worked on e-waste recycling and dismantling had significantly lower TSH compared with the control group (p<0.01). Moreover, the level of BDE-205 is positively associated with the level of T4, as confirmed by the linear regression model (unstandardized regression coefficient, beta=0.25, rho=0.001) and a weaker positive relation was also found between the levels of BDE-126 and T4. Meanwhile, a weak negative relation was found between the levels of PBB 103 and T3, and between the levels of fT3 and fT4. These results suggest that exposure to BFRs released from primitive e-waste handling may contribute to the changes of THs and TSH levels.
Wang
Hongmei
H
Department of Environment and Health, Chinese Research Academy of Environmental Sciences, Anwai Beiyuan Dayangfang No. 8, Chaoyang District 100012, PR China. wanghmxj@hotmail.com
Zhang
Yuan
Y
Liu
Qian
Q
Wang
Feifei
F
Nie
Jing
J
Qian
Yan
Y
D000328:Adult; D055615:Electrical Equipment and Supplies; D004784:Environmental Monitoring / Q000706:statistics & numerical data; D005411:Flame Retardants / Q000032:analysis* / Q000633:toxicity; D055768:Halogenated Diphenyl Ethers / Q000097:blood* / Q000633:toxicity; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D011075:Polybrominated Biphenyls / Q000097:blood* / Q000633:toxicity; D013961:Thyroid Gland / Q000187:drug effects*; D013963:Thyroid Hormones / Q000097:blood*; D018505:Waste Management; D055815:Young Adult
D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls; D013963:Thyroid Hormones