Ischemic cardiac complications following G-CSF.
Granulocyte-colony stimulating factor (G-CSF) is commonly used in bone marrow transplant donors to increase the number of circulating progenitor cells. G-CSF has also been studied following myocardial infarction, but concern has been raised about the risks of G-CSF administration in patients with coronary artery disease. We present two cases of ischemic cardiac complications that are likely to be related to administration of G-CSF and provide a contemporary overview of the literature on the cardiovascular risks of G-CSF.
Eckman
Peter M
PM
Department of Medicine, Division of Cardiology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA. eckmanp@umn.edu
Bertog
Stefan C
SC
Wilson
Robert F
RF
Henry
Timothy D
TD
D000368:Aged; D016026:Bone Marrow Transplantation; D003324:Coronary Artery Disease / Q000150:complications* / Q000000981:diagnostic imaging; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D012307:Risk Factors; D014182:Transplantation, Autologous; D018084:Ultrasonography, Interventional
D016179:Granulocyte Colony-Stimulating Factor