title: SIRS score on admission and initial concentration of IL-6 as severe acute pancreatitis outcome predictors.
abstract: OBJECTIVE
  Early recognition of severe form of acute pancreatitis is important because these patients need more agressive diagnostic and therapeutical approach an can develope systemic complications such as: sepsis, coagulopathy, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Dysfunction Syndrome (MODS), Multiple Organ Failure (MOF). To determine role of the combination of Systemic Inflammatory Response Syndrome (SIRS) score and serum Interleukin-6 (IL-6) level on admission as predictor of illness severity and outcome of Severe Acute Pancreatitis (SAP).
  
  
  METHODS
  We evaluated 234 patients with first onset of SAP appears in last twenty four hours. A total of 77 (33%) patients died. SIRS score and serum IL-6 concentration were measured in first hour after admission.
  
  
  RESULTS
  In 105 patients with SIRS score 3 and higher, initial measured IL-6 levels were significantly higher than in the group of remaining 129 patients (72 +/- 67 pg/mL, vs 18 +/- 15 pg/mL). All nonsurvivals were in the first group, with SIRS score 3 and 4 and initial IL-6 concentration 113 +/- 27 pg/mL. The values of C-reactive Protein (CRP) measured after 48h, Acute Physiology and Chronic Health Evaluation (APACHE II) score on admission and Ranson score showed the similar correlation, but serum amylase level did not correlate significantly with Ranson score, IL-6 concentration and APACHE II score.
  
  
  CONCLUSIONS
  The combination of SIRS score on admission and IL-6 serum concentration can be early, predictor of illness severity and outcome in SAP.
authors.affiliation: Center of Emergency Surgery, Clinical Center of Serbia and School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Pavle
authors.initials: P
authors.lastname: Gregoric
authors.forename: Gregoric
authors.initials: G
authors.lastname: Pavle
authors.forename: Ana
authors.initials: A
authors.lastname: Sijacki
authors.forename: Sijacki
authors.initials: S
authors.lastname: Ana
authors.forename: Sanja
authors.initials: S
authors.lastname: Stankovic
authors.forename: Stankovic
authors.initials: S
authors.lastname: Sanja
authors.forename: Dejan
authors.initials: D
authors.lastname: Radenkovic
authors.forename: Radenkovic
authors.initials: R
authors.lastname: Dejan
authors.forename: Nenad
authors.initials: N
authors.lastname: Ivancevic
authors.forename: Ivancevic
authors.initials: I
authors.lastname: Nenad
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Karamarkovic
authors.forename: Karamarkovic
authors.initials: K
authors.lastname: Aleksandar
authors.forename: Nada
authors.initials: N
authors.lastname: Popovic
authors.forename: Popovic
authors.initials: P
authors.lastname: Nada
authors.forename: Borivoje
authors.initials: B
authors.lastname: Karadzic
authors.forename: Karadzic
authors.initials: K
authors.lastname: Borivoje
authors.forename: Lazar
authors.initials: L
authors.lastname: Stijak
authors.forename: Branislav
authors.initials: B
authors.lastname: Stefanovic
authors.forename: Stefanovic
authors.initials: S
authors.lastname: Branislav
authors.forename: Zoran
authors.initials: Z
authors.lastname: Milosevic
authors.forename: Milosević
authors.initials: M
authors.lastname: Zoran
authors.forename: Djordje
authors.initials: D
authors.lastname: Bajec
authors.forename: Bajec
authors.initials: B
authors.lastname: Djordje
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein