Remediation effects on N170 and P300 in children with developmental dyslexia.
This study aimed at investigating the ERP correlates (N170 and P300 components) of a multimodal training program focused in dyslexia. ERPs were obtained from 32 electrodes in 24 French children with developmental dyslexia (mean age 10 years 7 months) during a visual lexical decision task. All the children received two intensive two-month evidence-based training programs: one based on phonemic awareness and the other on visual and orthographic processing in a cross-over design. Ten control children matched on chronological age were also tested. We showed dissociation between N170, P300 and behavioral improvement. In the dyslexic group, P300 amplitude decreased for non-words and words as the latter yielded performance improvement. In the control group, the same effect was observed for pseudo-words. At the same time, the opposite pattern occurred for the N170 latency, which was shortened for pseudo-words and pseudo-homophones in the dyslexic group and for words in the typically achieving children. We argue that training might modulate cortical activity in dyslexic children in a visual word recognition task. Considering the well-known implication of P300 in attentional processes, our results reflect the strong link between reading skill improvement after remediation and visual attentional process maturation.
Jucla
Mélanie
M
Inserm, Imagerie cérébrale et handicaps neurologiques UMR 825, Toulouse, France.
Nenert
Rodolphe
R
Chaix
Yves
Y
Demonet
Jean-François
JF
D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D018592:Cross-Over Studies; D004410:Dyslexia / Q000503:physiopathology* / Q000628:therapy*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005071:Evoked Potentials; D005260:Female; D005602:France; D006801:Humans; D007807:Language Tests; D007808:Language Therapy; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D010700:Phonetics; D011932:Reading; D021641:Recognition, Psychology / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome