title: In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.
abstract: The purpose of this study was to assess the feasibility to determine fetal blood oxygen saturation (sO(2)) with T(2)-weighted MR sequences using a fetal sheep model. T(2) measurements were performed on a 1.5-T scanner using a T(2) preparation pulse in combination with a three-dimensional balanced steady-state free precession sequence repeated at different echo times. Eight sheep fetuses were examined during a control, hypoxic, and recovery phase to perform T(2)-weighted scans of the fetal blood in the heart. Signal intensities in the left and right ventricle were measured to calculate the MR blood sO(2). During each phase, fetal carotid artery sO(2) was directly measured and correlated with MR sO(2). A Bland-Altman plot was performed. Fetal carotid artery sO(2) was 69% sO(2) during control, 16% sO(2) during hypoxemia, and 67% sO(2) during recovery. Mean values of the MR sO(2) were 49% sO(2) and 40% sO(2) for control, 6% sO(2) and 3% sO(2) for hypoxemia, and 51% sO(2) and 43% sO(2) for recovery in left ventricle and right ventricle, respectively. Mean values of fetal carotid artery sO(2) and MR sO(2) were highly correlated (left ventricle: r = 0.87, right ventricle: r = 0.89). According to the Bland-Altman plot, MR sO(2) was lower compared to fetal carotid artery sO(2) (left ventricle: 15%, right ventricle: 20%). Based on our preliminary results, it seems to be possible to assess fetal sO(2) with MR oximetry.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. wedegaer@uke.uni-hamburg.de
authors.forename: Ulrike
authors.initials: U
authors.lastname: Wedegärtner
authors.forename: Hendrik
authors.initials: H
authors.lastname: Kooijman
authors.forename: Jin
authors.initials: J
authors.lastname: Yamamura
authors.forename: Michael
authors.initials: M
authors.lastname: Frisch
authors.forename: Christoph
authors.initials: C
authors.lastname: Weber
authors.forename: Ralph
authors.initials: R
authors.lastname: Buchert
authors.forename: Anna
authors.initials: A
authors.lastname: Huff
authors.forename: Kurt
authors.initials: K
authors.lastname: Hecher
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D005312:Fetal Blood / Q000378:metabolism*; D005318:Fetal Heart / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D010100:Oxygen / Q000378:metabolism*; D011859:Radiography; D012756:Sheep
chemical_list: D010100:Oxygen