title: Bleeding disorders in neonates.
abstract: Bleeding disorders may present during the neonatal period, however, absent patient history along with unique physical signs, physiologically decreased levels of plasma proteins and laboratory variations of platelet function tests may render any diagnosis difficult to establish. Intra cranial haemorrhage (ICH) may be the clinical presenting symptom of a severe coagulation factor deficiency. Haemophilia in the newborn period poses unique challenges in diagnosis and management, Data presented from the UDC and similar surveillance systems world-wide can be used to further clinical research and improve management strategies. Development haemostasis should be considered as well as laboratory variations of coagulation tests while evaluating and diagnosis neonates suspected of bleeding disorders. Therapy of bleeding episodes in the neonate relies upon proper replacement and repeated haemostatic evaluation of patients' status, while dealing with underlying etiological causes. This manuscript discusses the unique aspects of clinical presentation, laboratory assessment, and treatment of various bleeding disorders in neonates.
authors.affiliation: Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel. Gili.Kenet@sheba.health.gov.il
authors.forename: G
authors.initials: G
authors.lastname: Kenet
authors.forename: A K C
authors.initials: AK
authors.lastname: Chan
authors.forename: J M
authors.initials: JM
authors.lastname: Soucie
authors.forename: R
authors.initials: R
authors.lastname: Kulkarni
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis*; D001792:Blood Platelets / Q000502:physiology; D005192:Family Health; D006467:Hemophilia A / Q000175:diagnosis; D006474:Hemorrhagic Disorders / Q000150:complications* / Q000175:diagnosis* / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000209:etiology*; D011296:Prenatal Diagnosis
chemical_list: D001779:Blood Coagulation Factors