title: Neuropsychiatric manifestations in Langerhans' cell histiocytosis disease: a case report and review of the literature.
abstract: The spectrum of the possible manifestations of Langerhans' cell histiocytosis in children is very wide, ranging from a simple rash to major multiorgan disease. There may be hypothalamic and pituitary dysfunction or more global neurological and neuropsychiatric manifestations when the central nervous system is affected. The cerebellum is preferentially affected for yet undetermined reasons. The clinical presentation includes motor dysfunction as well as cognitive, behavioral, and psychiatric expression of the ongoing neurodegeneration. We report a young patient with Langerhans' cell histiocytosis who underwent an unusual course of psychiatric deterioration.
authors.affiliation: Pediatric Neurology and Developmental Unit, Loewenstein Rehabilitation Hospital, Raanana, Israel. aviva100@bezeqint.net
authors.forename: Aviva
authors.initials: A
authors.lastname: Mimouni-Bloch
authors.forename: Carolina
authors.initials: C
authors.lastname: Schneider
authors.forename: Keren Elishkevitz
authors.initials: KE
authors.lastname: Politi
authors.forename: Osnat
authors.initials: O
authors.lastname: Konen
authors.forename: Doron
authors.initials: D
authors.lastname: Gothelf
authors.forename: Batia
authors.initials: B
authors.lastname: Stark
authors.forename: Isaac
authors.initials: I
authors.lastname: Yaniv
authors.forename: Avinoam
authors.initials: A
authors.lastname: Shuper
mesh_terms: D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000473:pathology / Q000628:therapy; D055815:Young Adult