[Normal tissue tolerance to external beam radiation therapy: small bowel].
The small bowel is a hollow organ involved in the transit and absorption of food. In relation to its anatomical location, a significant amount of this organ is exposed in whole or in part to ionizing radiation in external radiotherapy during abdominal or pelvic irradiation either for primary cancers or metastasis. The acute functional changes during external beam radiation are mainly leading to diarrhea, abdominal pain and bloating. The main late side effects of irradiation of the small intestine are chronic diarrhea, malabsorption with steatorrhea, abdominal spasms, intestinal obstruction, bleeding and fistulas. The architecture of the small intestine may be considered as parallel with a significant correlation between the irradiated volume of small bowel and the likelihood of acute toxicity, whatever the dose. The literature analysis recommends to consider the volume of small bowel receiving 15 Gy (threshold of 100 to 200 cm(3)) but also 30 and 50 Gy (thresholds of 35 to 300 cm(3), depending on the level of dose considered). Modern techniques of conformal radiotherapy with modulated intensity will probably have beneficial impact on small bowel toxicity.
Martin
E
E
Département de Radiothérapie, Centre Georges-Francois-Leclerc, 1 Rue du Professeur-Marion, 21079 Dijon cedex, France.
Pointreau
Y
Y
Roche-Forestier
S
S
Barillot
I
I
D000008:Abdominal Neoplasms / Q000532:radiotherapy; D001341:Autonomic Nervous System / Q000528:radiation effects; D003967:Diarrhea / Q000000981:diagnostic imaging / Q000209:etiology; D004063:Digestion / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D007408:Intestinal Absorption / Q000528:radiation effects; D007421:Intestine, Small / Q000294:innervation / Q000528:radiation effects*; D009130:Muscle, Smooth / Q000528:radiation effects; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D010146:Pain / Q000000981:diagnostic imaging / Q000209:etiology; D010386:Pelvic Neoplasms / Q000532:radiotherapy; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D011879:Radiotherapy Dosage; D012307:Risk Factors