title: Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
abstract: Prostate cancer is a major cause of mortality, largely as a consequence of metastases and transformation to androgen-independent growth. Metalloproteinases are implicated in cancer progression. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are expressed in prostate cancer cells, with ADAMTS-1 and ADAMTS-15 being the most abundant. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene. ADAMTS-15 expression is predictive for survival in breast cancer, and the situation may be similar in prostate cancer, as androgen independence is usually due to aberrant signaling through its receptor.
authors.affiliation: University of Sheffield Medical School, United Kingdom.
authors.forename: Chidi N
authors.initials: CN
authors.lastname: Molokwu
authors.forename: Olajumoke O
authors.initials: OO
authors.lastname: Adeniji
authors.forename: Shankar
authors.initials: S
authors.lastname: Chandrasekharan
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: David J
authors.initials: DJ
authors.lastname: Buttle
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000071096:ADAMTS Proteins; D000071097:ADAMTS1 Protein; D000728:Androgens / Q000502:physiology*; D000818:Animals; D045744:Cell Line, Tumor; D013196:Dihydrotestosterone / Q000494:pharmacology*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000235:genetics
chemical_list: D000728:Androgens; D013196:Dihydrotestosterone; D051722:ADAM Proteins; D000071096:ADAMTS Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human; C500267:ADAMTS15 protein, human