title: Treatment of recalcitrant Darier's disease with electron beam therapy.
abstract: Darier's disease (DD) is difficult to treat and has no cure. Although many modalities have been investigated, treatment options to date are largely unsatisfactory. Side-effect profiles have limited the use of many of these therapies, as has their ability to target only limited areas of disease. Furthermore, the effectiveness of most available treatments seems to be highly individualized, varying with disease severity and offering little alteration in the natural course of the disease. The present study reports a case of severe DD that was poorly responsive to known therapeutic modalities but responded to electron beam radiotherapy, and recommends this therapeutic modality for localized areas of severe, recalcitrant symptomatic disease.
authors.affiliation: Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Kittridge
authors.forename: Christina
authors.initials: C
authors.lastname: Wahlgren
authors.forename: Russell
authors.initials: R
authors.lastname: Fuhrer
authors.forename: Matthew
authors.initials: M
authors.lastname: Zirwas
authors.forename: Timothy
authors.initials: T
authors.lastname: Patton
mesh_terms: D007644:Darier Disease / Q000532:radiotherapy*; D004583:Electrons; D005260:Female; D006801:Humans; D008875:Middle Aged; D011882:Radiotherapy, High-Energy