title: Elevated MED28 expression predicts poor outcome in women with breast cancer.
abstract: BACKGROUND
  MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in in vitro and in vivo models. Here we examined the association of MED28 expression with human breast cancer progression.
  
  
  METHODS
  Expression of MED28 protein was determined on a population basis using a high-density tissue microarray consisting of 210 breast cancer patients. The association and validation of MED28 expression with histopathological subtypes, clinicopathological variables, and disease outcome was assessed.
  
  
  RESULTS
  MED28 protein expression levels were increased in ductal carcinoma in situ and invasive ductal carcinoma of the breast compared to non-malignant glandular and ductal epithelium. Moreover, MED28 was a predictor of disease outcome in both univariate and multivariate analyses with higher expression predicting a greater risk of disease-related death.
  
  
  CONCLUSIONS
  We have demonstrated that MED28 expression is increased in breast cancer. In addition, although the patient size was limited (88 individuals with survival information) MED28 is a novel and strong independent prognostic indicator of survival for breast cancer.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
authors.forename: Nam K
authors.initials: NK
authors.lastname: Yoon
authors.forename: Erin L
authors.initials: EL
authors.lastname: Maresh
authors.forename: Yahya
authors.initials: Y
authors.lastname: Elshimali
authors.forename: Ai
authors.initials: A
authors.lastname: Li
authors.forename: Steve
authors.initials: S
authors.lastname: Horvath
authors.forename: David B
authors.initials: DB
authors.lastname: Seligson
authors.forename: David
authors.initials: D
authors.lastname: Chia
authors.forename: Lee
authors.initials: L
authors.lastname: Goodglick
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000378:metabolism* / Q000556:secondary; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000453:epidemiology / Q000378:metabolism* / Q000556:secondary; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D056892:Mediator Complex / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D046888:Tissue Array Analysis
chemical_list: C496877:MED28 protein, human; D056892:Mediator Complex