title: Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases.
abstract: The UK was one of few European countries to document a substantial wave of pandemic (H1N1) 2009 influenza in summer 2009. The First Few Hundred (FF100) project ran from April-June 2009 gathering information on early laboratory-confirmed cases across the UK. In total, 392 confirmed cases were followed up. Children were predominantly affected (median age 15 years, IQR 10-27). Symptoms were mild and similar to seasonal influenza, with the exception of diarrhoea, which was reported by 27%. Eleven per cent of all cases had an underlying medical condition, similar to the general population. The majority (92%) were treated with antiviral drugs with 12% reporting adverse effects, mainly nausea and other gastrointestinal complaints. Duration of illness was significantly shorter when antivirals were given within 48 h of onset (median 5 vs. 9 days, P=0.01). No patients died, although 14 were hospitalized, of whom three required mechanical ventilation. The FF100 identified key clinical and epidemiological characteristics of infection with this novel virus in near real-time.
authors.affiliation: Health Protection Agency, Centre for Infections, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: McLean
authors.forename: R G
authors.initials: RG
authors.lastname: Pebody
authors.forename: C
authors.initials: C
authors.lastname: Campbell
authors.forename: M
authors.initials: M
authors.lastname: Chamberland
authors.forename: C
authors.initials: C
authors.lastname: Hawkins
authors.forename: J S
authors.initials: JS
authors.lastname: Nguyen-Van-Tam
authors.forename: I
authors.initials: I
authors.lastname: Oliver
authors.forename: G E
authors.initials: GE
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Ihekweazu
authors.forename: S
authors.initials: S
authors.lastname: Bracebridge
authors.forename: H
authors.initials: H
authors.lastname: Maguire
authors.forename: R
authors.initials: R
authors.lastname: Harris
authors.forename: G
authors.initials: G
authors.lastname: Kafatos
authors.forename: P J
authors.initials: PJ
authors.lastname: White
authors.forename: E
authors.initials: E
authors.lastname: Wynne-Evans
authors.forename: J
authors.initials: J
authors.lastname: Green
authors.forename: R
authors.initials: R
authors.lastname: Myers
authors.forename: A
authors.initials: A
authors.lastname: Underwood
authors.forename: T
authors.initials: T
authors.lastname: Dallman
authors.forename: T
authors.initials: T
authors.lastname: Wreghitt
authors.forename: M
authors.initials: M
authors.lastname: Zambon
authors.forename: J
authors.initials: J
authors.lastname: Ellis
authors.forename: N
authors.initials: N
authors.lastname: Phin
authors.forename: B
authors.initials: B
authors.lastname: Smyth
authors.forename: J
authors.initials: J
authors.lastname: McMenamin
authors.forename: J M
authors.initials: JM
authors.lastname: Watson
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D012307:Risk Factors; D012727:Sex Characteristics; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir