title: Impact of cytotoxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes.
abstract: Cytotoxin-associated gene A (CagA) positive strains of H. pylori have a significant correlation with gastritis and peptic ulcer, and may induce persistent systemic inflammatory response, increase vascular damage, and compromise glycemic control in diabetic patients. To evaluate correlation between infection by cagA positive strains of H. pylori and occurrence of microalbuminuria and glycemic control in type 2 diabetic patients, we prospectively studied 98 dyspeptic type 2 diabetic patients as a study group and 102 dyspeptic non-diabetic subjects as a control group. Gastric biopsy specimens obtained with endoscopy were cultured to isolate H. pylori. All the isolated H. pylori strains from cultures were used for detection of cagA gene by polymerase chain reaction. There was no significant difference between study and control groups regarding infection with cagA positive strains of H. pylori ( P= 0.145). Furthermore, there was no significant differences between both groups concerning the incidence of microalbuminuria ( P= 0.145). On the other hand, there was an extremely statistically significant difference in the incidence of microalbuminuria and glycemic control in the diabetic patients between those infected with cagA positive strains of H. pylori and cag A negative starins (P= 0.000). We conclude that infection with cagA positive strains of H. pylori are strongly associated with the increased incidence of microalbuminuria and poor glycemic control in type 2 diabetic patients.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Amany
authors.initials: A
authors.lastname: Ibrahim
authors.forename: Tarik
authors.initials: T
authors.lastname: Zaher
authors.forename: Tarek A
authors.initials: TA
authors.lastname: Ghonemy
authors.forename: Shymaa Abd
authors.initials: SA
authors.lastname: El-Azim
authors.forename: Marwa Abd
authors.initials: MA
authors.lastname: El-Azim
authors.forename: Ayman
authors.initials: A
authors.lastname: Ramadan
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000150:complications / Q000382:microbiology*; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000382:microbiology; D003928:Diabetic Nephropathies / Q000382:microbiology; D005260:Female; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016133:Polymerase Chain Reaction; D011446:Prospective Studies
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D017931:DNA Primers; C080866:cagA protein, Helicobacter pylori