title: A Ru(II)-TAP complex, photoreagent for tryptophan-containing peptides: structure of the covalent photoadduct.
abstract: We report the first structure determination of a covalent photoadduct between a Ru(II)-tap complex and a tryptophan-containing peptide (AlaTrpAla) by mass spectrometry and NMR spectroscopy. Ru(II)-tap complexes could thus be exploited as photodamaging agents of Trp-containing polypeptides or proteins.
authors.affiliation: Service de Chimie Organique et Photochimie, Université libre de Bruxelles, 50 Av. F.D. Roosevelt, B-1050 Bruxelles, Belgium.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gauthier
authors.forename: Julien
authors.initials: J
authors.lastname: De Winter
authors.forename: Pascal
authors.initials: P
authors.lastname: Gerbaux
authors.forename: Cécile
authors.initials: C
authors.lastname: Moucheron
authors.forename: Michel
authors.initials: M
authors.lastname: Luhmer
authors.forename: Andrée
authors.initials: A
authors.lastname: Kirsch-De Mesmaeker
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism*; D010616:Phenanthrenes / Q000737:chemistry* / Q000378:metabolism*; D055668:Photochemical Processes; D014364:Tryptophan / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D009842:Oligopeptides; D009942:Organometallic Compounds; D010616:Phenanthrenes; C076699:ruthenium-tris-1,4,5,8-tetraazaphenanthrene; D014364:Tryptophan