Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine.
A 36-year-old female patient who was diagnosed with chronic myocarditis as an initial manifestation of systemic lupus erythematosus (SLE) was admitted to our hospital. At her third occurrence of heart failure, we performed an endomyocardial biopsy and proved chronic myocarditis with SLE. Subsequently, she was treated with prednisolone and the immunosuppressive agent mizoribine (MZR), and her cardiac function improved. We describe for the first time treatment with MZR for chronic cardiac involvement of SLE.
Akazawa
Satoru
S
Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Ichinose
Kunihiro
K
Origuchi
Tomoki
T
Kawashiri
Shin-ya
SY
Iwamoto
Naoki
N
Fujikawa
Keita
K
Aramaki
Toshiyuki
T
Kamachi
Makoto
M
Arima
Kazuhiko
K
Tamai
Mami
M
Nakamura
Hideki
H
Ida
Hiroaki
H
Kawakami
Atsushi
A
Eguchi
Katsumi
K
D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009205:Myocarditis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*; D016896:Treatment Outcome
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D011239:Prednisolone