title: Infectious crystalline keratopathy treated with intrastromal antibiotics.
abstract: An 84-year-old white female with nonprogressive conjunctival scarring developed infectious crystalline keratopathy (ICK) recalcitrant to topical therapy. After determination of the causative organism's antibiotic sensitivities, superficial keratectomy was performed with intrastromal corneal infiltration of cefuroxime into the affected cornea. Postoperatively, the ICK resolved completely, leading to an improvement in visual acuity and a reduction in ocular irritation. This case highlights the importance of a surgical approach in ICK and also demonstrates the possible benefit of a novel use of intracorneal antibiotics as an adjunct.
authors.affiliation: Academic Unit of Ophthalmology, School of Infection and Immunity, College of Medical and Dental Sciences, University of Birmingham, Birmingham and Midland Eye Centre, Birmingham, United Kingdom. drijk@doctors.org.uk
authors.forename: Imran J
authors.initials: IJ
authors.lastname: Khan
authors.forename: Samer
authors.initials: S
authors.lastname: Hamada
authors.forename: Saaeha
authors.initials: S
authors.lastname: Rauz
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D003319:Corneal Stroma / Q000187:drug effects*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007267:Injections; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D034361:Streptococcus mitis / Q000302:isolation & purification*; D014792:Visual Acuity
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime