Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.
Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.
Utsumi
Takako
T
Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia. tutsumi@people.kobe-u.ac.jp
Yano
Yoshihiko
Y
Lusida
Maria Inge
MI
Amin
Mochamad
M
Soetjipto
Hotta
Hak
H
Hayashi
Yoshitake
Y
D002353:Carrier State / Q000276:immunology*; D002648:Child; D004279:DNA, Viral / Q000032:analysis*; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007214:Indonesia; D008297:Male; D010349:Patient Compliance; D015995:Prevalence; D018570:Risk Assessment; D012959:Socioeconomic Factors; D014611:Vaccination
D004279:DNA, Viral