New chaps in the histone chaperone arena.
Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253-1265) identified DAXX as a novel H3.3-specific chaperone. This finding, in the context of others published by Goldberg and colleagues in Cell and Sawatsubashi and colleagues (pp. 159-170) in the January 15, 2010, issue of Genes & Development, provides the impetus for uncovering the mechanistic and functional properties of alternative histone deposition pathways.
Campos
Eric I
EI
Department of Biochemistry, Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.
Reinberg
Danny
D
D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D014644:Genetic Variation; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D040582:Inheritance Patterns; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D006657:Histones; D018832:Molecular Chaperones