[CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Effect of vitamin D on kidney and cardiovascular system].
Recently, many investigators have reported that treatment with vitamin D improves outcomes of patients with chronic kidney disease. Though the detailed mechanisms have remained unclear, it has been speculated that such a treatment may prevent progression of chronic kidney disease and cardiovascular disease. It has been reported that Vitamin D may attenuate renal injury and ameliorate renal function and proteinuria. In addition, several studies have shown that vitamin D may prevent progression of atherosclerosis, vascular calcification and left ventricular hypertrophy. The emerging experimental and clinical evidence has suggested that vitamin D may protect kidney and cardiovascular system.
Fujii
Hideki
H
Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine.
D050197:Atherosclerosis / Q000517:prevention & control*; D002114:Calcinosis / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002908:Chronic Disease; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000517:prevention & control; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000150:complications / Q000517:prevention & control*; D018167:Receptors, Calcitriol / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D018417:Th1 Cells / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*; D014809:Vitamin D-Binding Protein / Q000378:metabolism
D018167:Receptors, Calcitriol; D016212:Transforming Growth Factor beta; D014809:Vitamin D-Binding Protein; D014807:Vitamin D