The lipid peroxidation in breast cancer patients.
The aim of our study was to estimate oxidative stress (by using different biomarkers of lipid peroxidation--isoprostanes and thiobarbituric acid reactive substances (TBARS)) in patients with invasive breast cancer, patients with benign breast diseases and in a control group. We observed a statistically increased level of TBARS in plasma and isoprostanes in urine of patients with invasive breast cancer in comparison with a control group. The concentration of tested biomarkers in plasma or urine from patients with invasive breast cancer was also higher than in patients with benign breast diseases. Moreover, the levels of tested markers in patients with benign breast diseases and in a control group did not differ. Considering the data presented in this study, we suggest that free radicals induce peroxidation of unsaturated fatty acid in patients with breast cancer.
Kedzierska
Magdalena
M
Department of General Biochemistry, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Olas
Beata
B
Wachowicz
Barbara
B
Jeziorski
Arkadiusz
A
Piekarski
Janusz
J
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001941:Breast Diseases / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism*; D016022:Case-Control Studies; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D028421:Isoprostanes / Q000652:urine; D015227:Lipid Peroxidation; D008875:Middle Aged; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D055815:Young Adult
D015415:Biomarkers; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D028421:Isoprostanes; D017392:Thiobarbituric Acid Reactive Substances; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost