title: Patlak plot analysis CT-GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs.
abstract: Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single-slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT-derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 +/- 0.058 ml min(-1) ml renal tissue(-1)) compared with control dogs (0.396 +/- 0.139 ml min(-1) ml renal tissue(-1)). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R(2) = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT-GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models.
authors.affiliation: Faculté de médecine vétérinaire, Université de Montréal, PO Box 5000, St-Hyacinthe, Quebec, J2S 7C6, Canada. kate.alexander@umontreal.ca
authors.forename: K
authors.initials: K
authors.lastname: Alexander
authors.forename: S
authors.initials: S
authors.lastname: Authier
authors.forename: J R E
authors.initials: JR
authors.lastname: del Castillo
authors.forename: V
authors.initials: V
authors.lastname: Arora
authors.forename: S
authors.initials: S
authors.lastname: Qi
authors.forename: M
authors.initials: M
authors.lastname: Guillot
authors.forename: G
authors.initials: G
authors.lastname: Beauchamp
authors.forename: E
authors.initials: E
authors.lastname: Troncy
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000502:physiology*; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology; D016030:Kidney Transplantation / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003404:Creatinine