title: Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot.
abstract: BACKGROUND
  The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations.
  
  
  METHODS
  Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested.
  
  
  RESULTS
  Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters.
  
  
  CONCLUSIONS
  HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT.
authors.affiliation: Department of Internal Medicine, Gulhane Military Medical Academy, Ankara, Turkey. drnkaradurmus@yahoo.com
authors.forename: Nuri
authors.initials: N
authors.lastname: Karadurmus
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Canturk
authors.initials: C
authors.lastname: Tasci
authors.forename: Ilkin
authors.initials: I
authors.lastname: Naharci
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.forename: Savas
authors.initials: S
authors.lastname: Ilbasmis
authors.forename: Zeki
authors.initials: Z
authors.lastname: Dulkadir
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sen
authors.forename: Kenan
authors.initials: K
authors.lastname: Saglam
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D017719:Diabetic Foot / Q000150:complications* / Q000628:therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human