Novel one-pot method for chemoselective bromination and sequential Sonogashira coupling.
An efficient one-pot method for bromination-elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalkanes having an adjacent O-functional group.
Kutsumura
Noriki
N
Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. nkutsu@rs.kagu.tus.ac.jp
Niwa
Kentaro
K
Saito
Takao
T
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D054879:Halogenation; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*
D020005:Propanols; C006463:allyl alcohol