title: Facile benzo-ring construction via palladium-catalyzed functionalization of unactivated sp3 C-H bonds under mild reaction conditions.
abstract: A practical synthetic method for the annulation of benzo-rings by the intramolecular coupling of an aryl iodide and a methylene C-H bond is described. The palladium-catalyzed C-H functionalization is directed by an aminoquinoline carboxamide group, which can be easily installed and removed. High yields and broad substrate scope were achieved. An additive of ortho-phenyl benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, Pensylvania 16802, USA.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Feng
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wang
authors.forename: Bradley
authors.initials: B
authors.lastname: Landgraf
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.forename: Gong
authors.initials: G
authors.lastname: Chen