title: "Clickable", polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions.
abstract: A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide-alkyne cycloaddition (a "click" reaction) are optimized for rapid attachment of azides with controlled composition onto the liposomes.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Uriel J
authors.initials: UJ
authors.lastname: Erasquin
authors.forename: Guoting
authors.initials: G
authors.lastname: Qin
authors.forename: King
authors.initials: K
authors.lastname: Li
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Cai
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry; D053279:Polyynes / Q000737:chemistry; D051381:Rats
chemical_list: D000480:Alkynes; D001386:Azides; D008081:Liposomes; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D003300:Copper