title: Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells.
abstract: A new fluorescent turn-on probe for the rapid optical sensing of thiols has been designed and synthesized. The probe displays high on/off signal ratios and high selectivity towards thiols. The potential of the probe as a biosensor for thiols was demonstrated by imaging of thiols in living cells.
authors.affiliation: ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Shijing
authors.initials: S
authors.lastname: Qian
authors.forename: Qiaojun
authors.initials: Q
authors.lastname: He
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Yongzhou
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000032:analysis / Q000138:chemical synthesis*; D019556:COS Cells; D002470:Cell Survival; D002522:Chlorocebus aethiops; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000032:analysis*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds