Acute effect of a single high-fat meal on forearm blood flow, blood pressure and heart rate in healthy male Asians and Caucasians: a pilot study.
Research has shown that ingestion of a single high-fat (HF) meal causes postprandial lipemia and produces a reduced brachial artery blood flow response to vascular occlusion in Caucasians. However, the forearm BF response to occlusion in Caucasian and Asian populations after a single HF meal has not been compared. Eleven healthy male Asians, mean age 26.4 (+/- 4.2) years, height 174.2 (+/- 7.4) cm, and weight 73.8 (+/- 5.7) kg and eight Caucasians, mean age 26.8 (+/- 4.6) years, height 182.9 (+/- 5.9) cm, and weight 82.8 (+/- 4.8) kg were studied. A randomized cross-over study design was used with a HF (50.1 g total fat) or low-fat (LF) (5.1 g total fat) test meal 1 week apart. Forearm blood flow was measured over a 2-minute period following a 4-minute occlusion (FBFO) at 2 and 4 hours following ingestion of a test meal. This study found that FBFO was significantly attenuated in Asians (19.3%; p = 0.09) compared to Caucasians after the ingestion of a HF meal. When comparing LF vs. HF meals in Asians, the FBFO were 336.9 ml/100 ml tissue/ minute and 240.8 ml/100 ml tissue/minute, respectively (p = 0.02), whereas in Caucasians, the FBFO were 344.8 ml/100 ml tissue/minute and 287.4 ml/100 ml tissue/minute, respectively. It appears Asians have a more sensitive response to a single HF meal which may be explained, in part, by genotypic variation. These findings suggest that a single HF meal may contribute to the detrimental effects on vascular health in Asian males and raises speculation regarding the cumulative impact of a chronic HF diet in this population.
Bui
Chumjit
C
Department of Health Promotion and Education, School of Public Health, Loma Linda University, Loma Linda, CA, USA. ccharasuraisin06p@llu.edu
Petrofsky
Jerrold
J
Berk
Lee
L
Shavlik
David
D
Remigio
Wilton
W
Montgomery
Susanne
S
D000328:Adult; D001213:Asian; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects*; D005542:Forearm / Q000098:blood supply*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D010991:Plethysmography; D019518:Postprandial Period; D044465:White People
D004041:Dietary Fats