title: A new sclerosing agent in the treatment of venous malformations. Study on 23 cases.
abstract: Absolute ethanol is the most effective agent in the treatment of venous malformation (VM) although it is quite risky to use because of the danger of diffusion beyond the target. To reduce this risk, we have developed an alcoholic sclerosing solution that is less diffusible. The viscosity of absolute ethanol was enhanced with monographic ethyl-cellulose at a concentration of 5.88% ie 0.75 g in 15 ml of absolute ethanol 95%. 23 patients with VM located on the buttock (1), hand (2), leg (1) and face (19) were treated. A mean volume of 1.99 ml of the solution was injected directly into the VM. Each patient had an average of 2.8 procedures. Sixteen patients were done under general anaesthesia and seven with local anaesthesia. Evaluation was performed by the patient, the dermatologist of the treating multidisciplinary team and a dermatological group not involved in the treatment of the patients. Patients were evaluated after a mean delay of 24.52 months. Evaluation of the cosmetic result was made with a five point scale and the global result with a three point scale. VM pain was evaluated by the patients with a Visual Analogue Scale. The aesthetic results were graded as satisfactory (> 3) for the patient and the dermatologist of the multidisciplinary team. However the results were not as good with the independent dermatological group evaluation. The pain was significantly less important after the treatment (p << 0.001). Among the 23 patients, the local adverse events were nine necrosis with or without ethylcellulose fistula followed by only two surgical procedures. There were no systemic adverse events. Sclerotherapy of VM is usually performed with absolute ethanol or ethibloc. The main advantage of our sclerosing mixture is that it expands like a balloon when injected slowly in a aqueous media. Because of the important increase in viscosity the volume of injected solution is much lower than ethanol alone and the risk of systemic reactions is lower. Contrary to ethibloc, post-sclerosing surgery is not necessary because sub-cutaneous ethylcellulose disappears secondarily.
authors.affiliation: Services de Dermatologie, Centre Hospitalier Universitaire de Caen, Cedex; France - dompmartin-a@chu-caen.fr.
authors.forename: K
authors.initials: K
authors.lastname: Sannier
authors.forename: A
authors.initials: A
authors.lastname: Dompmartin
authors.forename: J
authors.initials: J
authors.lastname: Théron
authors.forename: D
authors.initials: D
authors.lastname: Labbé
authors.forename: M T
authors.initials: MT
authors.lastname: Barrellier
authors.forename: R
authors.initials: R
authors.lastname: Leroyer
authors.forename: P
authors.initials: P
authors.lastname: Touré
authors.forename: D
authors.initials: D
authors.lastname: Leroy