title: Intrauterine growth restriction in a low-income country: Risk factors, adverse perinatal outcomes and correlation with current WHO Multicenter Growth Reference.
abstract: OBJECTIVE
  To determine risk factors and adverse perinatal outcomes including nutritional status in the first week of life for newborns with intrauterine growth restriction-low birth weight (IUGR-LBW) in settings lacking facilities for routine intrauterine growth monitoring.
  
  
  METHODS
  A cross-sectional study of all infants in an inner-city hospital in Lagos, Nigeria. IUGR-LBW was defined as full-term (gestational age> or =37 weeks) infant with low birth weight (<2500g). Nutritional/growth status at enrolment was determined by z-scores for length-for-age (HAZ), head circumference-for-age (HCZ), weight-for-age (WAZ) and weight-for-length (WHZ) based on current World Health Organization's Multicentre Growth Reference (WHO-MGR). Factors and adverse outcomes associated with IUGR-LBW were explored with multivariable logistic regression analyses.
  
  
  RESULTS
  Some 145 (4.3%) infants were IUGR-LBW out of 2619 eligible singletons enlisted for this study. IUGR-LBW was significantly associated with teenage mothers (OR:2.90, 95% CI:1.22-6.89), lack of antenatal care (OR:1.88, 95% CI:1.33-2.65) and female gender (OR:1.38, 95% CI: 0.98-1.93; p=0.062). The incidence of adverse outcomes across gestational age showed significant linear trend only for low five-minute Apgar scores (p=0.024) and WAZ (p=0.065). IUGR-LBW was associated with poor nutritional status across all four indices (p<0.001) as well as low 5-minute Apgar scores (p=0.095), sepsis (p=0.053), hyperbilirubinemia (p<0.001) and admission into special care baby unit (p=0.009) after multivariable logistic regression analyses.
  
  
  CONCLUSIONS
  IUGR-LBW correlates with poor nutritional status in the first week of life based on WHO-MGR and affected infants can be detected early for effective surveillance in resource-poor settings. Improved prenatal care among teenage mothers is necessary for reducing IUGR-LBW burden.
authors.affiliation: Department of Community Health and Primary Care, University of Lagos, Idiaraba, Surulere, Nigeria. boolusanya@aol.com
authors.forename: Bolajoko O
authors.initials: BO
authors.lastname: Olusanya
mesh_terms: D001034:Apgar Score; D049628:Body Size; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology* / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight / Q000254:growth & development*; D007231:Infant, Newborn; D009549:Nigeria; D009752:Nutritional Status; D011247:Pregnancy; D011295:Prenatal Care; D012307:Risk Factors; D014944:World Health Organization