Neuromediators in inflammation--a macrophage/nerve connection.
Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted over the last two decades implicate that macrophage responses are also modulated by neuronal mediators such as neurotransmitters or neurotrophic factors. Here we summarize the current understanding of neuromediator-dependent interplay between macrophages and the nervous system.
Ley
Stephanie
S
Institute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Weigert
Andreas
A
Brüne
Bernhard
B
D000818:Animals; D006801:Humans; D007249:Inflammation; D008264:Macrophages / Q000502:physiology*; D009416:Nerve Regeneration / Q000276:immunology; D015213:Neuroimmunomodulation; D009474:Neurons / Q000276:immunology*; D018377:Neurotransmitter Agents / Q000276:immunology* / Q000378:metabolism
D018377:Neurotransmitter Agents