Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.
We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).
Green
Elaine K
EK
Department of Psychological Medicine and Neurology, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom. greenek@cf.ac.uk
Grozeva
Detelina
D
Moskvina
Valentina
V
Hamshere
Marian L
ML
Jones
Ian R
IR
Jones
Lisa
L
Forty
Liz
L
Caesar
Sian
S
Gordon-Smith
Katherine
K
Fraser
Christine
C
Russell
Ellie
E
St Clair
David
D
Young
Allan H
AH
Ferrier
Nicol
N
Farmer
Anne
A
McGuffin
Peter
P
Holmans
Peter A
PA
Owen
Michael J
MJ
O'Donovan
Michael C
MC
Craddock
Nick
N
D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C547868:GABRR1 protein, human; D011963:Receptors, GABA-A