Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models.
The study was designed to examine the effects of polydatin on ventricular remodeling induced by isoproterenol in mice and by abdominal aortic banding in rats. Polydatin reduced cardiac weight indexes in mice and rats, lowered the contents of cyclic AMP and angiotensin II in mice. It also decreased the size of cardiomyocyte, the levels of aldosterone, tumor necrosis factor-α, angiotensin II and endothelin-1, reduced ventricular collagen volume and decreased blood pressure in rats. The results demonstrate that polydatin has the beneficial effects on attenuating ventricular remodeling, which are associated with its inhibiting the activation of neurohormone, especially in rennin-angiotensin-aldosterone system.
Gao
Jian Ping
JP
Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chen
Chang Xun
CX
Gu
Wei Liang
WL
Wu
Qi
Q
Wang
Ying
Y
Lü
Jian
J
D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001012:Aorta, Abdominal; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000378:metabolism; D045468:Fallopia japonica / Q000737:chemistry*; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007545:Isoproterenol; D008297:Male; D051379:Mice; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012084:Renin-Angiotensin System / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D020257:Ventricular Remodeling / Q000187:drug effects*
D002317:Cardiovascular Agents; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D005960:Glucosides; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D000804:Angiotensin II; D000450:Aldosterone; D003094:Collagen; D000242:Cyclic AMP; D007545:Isoproterenol; C058229:polydatin