title: Coexistence of primary pulmonary Hodgkin lymphoma and gastric MALT lymphoma associated with Epstein-Barr virus infection: a case report.
abstract: We describe a 66-year-old woman with Epstein-Barr virus-associated lymphoproliferative disorder with lung and gastric tumors. We identified two lung tumors measuring 13 and 20 mm in diameter that consisted of CD30-, CD15-, and CD20-positive Hodgkin- and Reed-Sternberg-like cells and heterogeneous cellular infiltrates in a pronounced nodular pattern, with necrosis and vasculitis, diagnosed as nodular sclerosis classical Hodgkin lymphoma. A gastric tumor showed low-grade extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type. Neoplastic cells in all tumors expressed Epstein-Barr virus-encoded RNA based on in situ hybridization. The present case is a rare composite lymphoma arising from different extranodal organs, associated with EBV infection. Her medical history included gamma-knife therapy for clinical diagnosis with a suspicion of cerebral lymphoma.
authors.affiliation: Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Oka
authors.forename: Mayumi
authors.initials: M
authors.lastname: Shinonaga
authors.forename: Reizo
authors.initials: R
authors.lastname: Nagayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kashimura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yonekawa
authors.forename: Sho
authors.initials: S
authors.lastname: Tatebe
authors.forename: Setsuo
authors.initials: S
authors.lastname: Kuraoka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Mori
mesh_terms: D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology* / Q000821:virology; D006801:Humans; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000473:pathology* / Q000821:virology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000821:virology; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000821:virology; D013274:Stomach Neoplasms / Q000473:pathology* / Q000821:virology