title: Potential for chlorine gas-induced injury in the extrapulmonary vasculature.
abstract: Exposure to chlorine gas (Cl(2)) primarily causes injury to the lung and is characterized by inflammation and oxidative stress mediated by reactive chlorine species. Reducing lung injury and improving respiratory function are the principal therapeutic goals in treating individuals exposed to Cl(2) gas. Less is known on the potential for Cl(2) gas exposure to cause injury to extrapulmonary tissues and specifically to mediate endothelial dysfunction. This concept is forwarded in this article on the basis that (1) many irritant gases whose reactivity is limited to the lung have now been shown to have effects that promote endothelial dysfunction in the systemic vasculature, and as such lead to the acute and chronic cardiovascular disease events (e.g., myocardial infarctions and atherosclerosis); and (2) that endogenously produced reactive chlorine species are now considered to be central in the development of cardiovascular diseases. This article discusses these two areas with the view of providing a framework in which potential extrapulmonary toxic effects of Cl(2) gas exposure may be considered.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA.
authors.forename: Andrey
authors.initials: A
authors.lastname: Samal
authors.forename: Jaideep
authors.initials: J
authors.lastname: Honovar
authors.forename: C Roger
authors.initials: CR
authors.lastname: White
authors.forename: Rakesh P
authors.initials: RP
authors.lastname: Patel
mesh_terms: D001808:Blood Vessels / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D002713:Chlorine / Q000737:chemistry / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005740:Gases / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects*; D008171:Lung Diseases / Q000139:chemically induced*; D009569:Nitric Oxide / Q000096:biosynthesis; D018384:Oxidative Stress
chemical_list: D005740:Gases; D009569:Nitric Oxide; D002713:Chlorine