title: Glubran 2((r)):a new acrylic glue for neuroradiological endovascular use: a complementary histological study.
abstract: Two Landrace Large White swine underwent angiography by the femoral route. In both cases, the superior left renal artery was embolized by injection of 2 ml of Glubran 2((R)), diluted with Lipiodol 1:1 thereby excluding the superior left kidney poles from blood flow. During the follow-up period, neither pig presented any clinical symptom correlated to the embolization procedure. Case 1 was sacrificed after 30 days and case 2 after 60 days. Macroscopic and microscopic analysis was performed in both animals. Long-term follow-up of the two cases after endovascular injection of Glubran 2((R)) showed that the embolization procedure was well-tolerated by the swine in terms of clinical symptoms and histological findings. Arterial occlusion was stable and a reasonable quantity of scar tissue appeared between 30 and 60 days, surrounding the ischaemic tissue. This follow-up experimental study offers further evidence that Glubran 2((R)) is a safe embolizing material for human use as far as its chemical activity is concerned.
authors.affiliation: Servizio di Neuroradiologia, Ospedale Bellaria; Bologna.
authors.forename: M
authors.initials: M
authors.lastname: Leonardi
authors.forename: P
authors.initials: P
authors.lastname: Cenni
authors.forename: L
authors.initials: L
authors.lastname: Simonetti
authors.forename: A
authors.initials: A
authors.lastname: Bozzao
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: M
authors.initials: M
authors.lastname: Bonamini
authors.forename: L M
authors.initials: LM
authors.lastname: Fantozzi
authors.forename: G
authors.initials: G
authors.lastname: Fini