Association of serum phosphorus with left ventricular mass in men and women with stable cardiovascular disease: data from the Heart and Soul Study.
BACKGROUND
Higher serum phosphorus levels are associated with cardiovascular disease (CVD) events in the general population, an association that may be stronger in men. Estradiol has phosphaturic properties. Whether higher serum phosphorus levels are associated with left ventricular (LV) mass in persons without end-stage renal disease and whether the association is modified by sex is unknown.


METHODS
Cross-sectional observational study.


METHODS
978 outpatients with stable CVD.


METHODS
The primary predictor variable was serum phosphorus level. Sex was evaluated as an effect modifier.


METHODS
LV mass using transthoracic echocardiography.


RESULTS
The association of serum phosphorus level with LV mass differed by sex (interaction P=0.04). In models adjusted for age, race, kidney function, smoking, diabetes, blood pressure, cholesterol level, C-reactive protein level, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use, each 1-mg/dL higher serum phosphorus level was associated with 4.52-g/m2 greater LV mass (95% CI, 1.04-8.01; P=0.01) in men. Conversely, in women, no statistically significant association was found between serum phosphorus level and LV mass.


CONCLUSIONS
Older adult population with stable CVD; 19% were women.


CONCLUSIONS
In outpatients with stable CVD, higher serum phosphorus levels are associated with greater LV mass in men, but not women. Whether sex hormones may account for these differences requires future study.
Saab
Georges
G
Harry S. Truman Veterans Affairs Hospital, Columbia, MO, USA.
Whooley
Mary A
MA
Schiller
Nelson B
NB
Ix
Joachim H
JH
D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D012737:Sex Factors
D010758:Phosphorus