Flipping MLL1's switch one proline at a time.
The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.
Grow
Edward J
EJ
Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Wysocka
Joanna
J