The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.
OBJECTIVE
To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.


METHODS
Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dose statin; FA alone; or low-, moderate-, or high-dose statin alone.


RESULTS
FA + low- or moderate-dose statin combination therapy reduced the presence of metabolic syndrome (35.7 or 35.9%, respectively) more than low-, moderate-, or high-dose statin monotherapy (15.5, 16.6, or 13.8%, respectively), mostly due to improvements in triglycerides and HDL cholesterol levels. Mean glucose levels slightly decreased with FA monotherapy, slightly increased with statin monotherapy, and were essentially unchanged with FA + statin. FA with or without statin also reduced non-HDL cholesterol, apolipoprotein B, total cholesterol, VLDL cholesterol, and high-sensitivity C-reactive protein.


CONCLUSIONS
FA + statin in patients with mixed dyslipidemia reduces the prevalence of metabolic syndrome.
Bays
Harold E
HE
Louisville Metabolic and Atherosclerosis Research Center, Louisville, Kentucky, USA. hbaysmd@aol.com
Roth
Eli M
EM
McKenney
James M
JM
Kelly
Maureen T
MT
Thakker
Kamlesh M
KM
Setze
Carolyn M
CM
Obermeyer
Katie
K
Sleep
Darryl J
DJ
D050171:Dyslipidemias / Q000188:drug therapy* / Q000453:epidemiology; D011345:Fenofibrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000453:epidemiology; D019821:Simvastatin / Q000008:administration & dosage / Q000627:therapeutic use*
D000960:Hypolipidemic Agents; D019821:Simvastatin; C006012:fenofibric acid; D011345:Fenofibrate