title: Mini extracorporeal circuit cardiopulmonary bypass system: a review.
abstract: Improved knowledge of the pathophysiological processes experienced in response to cardiopulmonary bypass has led to new developments in extracorporeal technology and understanding. The use of mini extracorporeal circuits (MECC) is rapidly expanding in clinical practice. The mini extracorporeal circuit differs by a greatly reduced tubing length and the number of components when compared with current circuit designs. The MECC is believed to offer potential benefits to the surgical patient by reducing the systemic inflammatory response that remains strongly implicated in post-operative organ dysfunction. We present a review of the available literature and find the MECC to show an acceptable safety profile with a reduction in post-operative complications and transfusion requirements and no evidence of any negative impairment to the surgeon, anaesthetist or perfusionist. The observed post-bypass inflammatory response is seen to be lower after MECC bypass and this is of clear clinical benefit.
authors.affiliation: Wessex Cardiothoracic Department, Southampton General Hospital, Southampton, UK.
authors.forename: Nathan
authors.initials: N
authors.lastname: Curtis
authors.forename: Hunaid A
authors.initials: HA
authors.lastname: Vohra
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Ohri
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology