title: Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients.
abstract: OBJECTIVE
  Coenzyme Q(10) (CoQ(10)) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ(10) levels, mitochondrial dysfunction, and oxidative stress in plasma, blood mononuclear cells, and skin biopsies from FM patients.
  
  
  METHODS
  We studied CoQ(10) level by HPLC in plasma, blood mononuclear cells, and skin obtained from patients with FM and healthy control subjects. Oxidative stress markers and mitochondrial respiratory chain enzyme activities were analysed in both plasma, blood mononuclear cells, and skin biopsies from FM patients.
  
  
  RESULTS
  Oxidative stress, mitochondrial dysfunction, and CoQ(10) deficiency have been observed in blood mononuclear cells and skin biopsies.
  
  
  CONCLUSIONS
  In our patients, mitochondrial dysfunction and CoQ(10) deficiency are present in several tissues. These results may contribute to the understanding of the pathophysiology of FM, and, moreover, CoQ(10) deficiency could represent a good marker for the diagnosis of FM.
authors.affiliation: Centro Andaluz de Biología del Desarrollo, CABD, Universidad Pablo de Olavide-CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, CIBERER, ISCIII, Sevilla, Spain. mdcormor@upo.es
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
authors.forename: Ana M
authors.initials: AM
authors.lastname: Moreno-Fernández
authors.forename: María I
authors.initials: MI
authors.lastname: Carmona-López
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sánchez-Alcázar
authors.forename: Ana Fernández
authors.initials: AF
authors.lastname: Rodríguez
authors.forename: Plácido
authors.initials: P
authors.lastname: Navas
authors.forename: Manuel
authors.initials: M
authors.lastname: de Miguel
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001773:Blood Cells; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008928:Mitochondria / Q000473:pathology*; D028361:Mitochondrial Diseases; D018384:Oxidative Stress; D012867:Skin / Q000473:pathology*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000032:analysis
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10