Green preparation process, characterization and antitumor effects of doxorubicin-BSA-dextran nanoparticles.
In this report, we developed a simple and green process of simultaneous formation of doxorubicin-BSA-dextran nanoparticles in aqueous solution and high-effective encapsulation of doxorubicin. In the presence of BSA-dextran conjugates, which were produced by Maillard reaction, a binding of doxorubicin with BSA can suppress the self-aggregation of unprotonated doxorubicin. After a heat treatment, the gelation of BSA results in a formation of the nanoparticles and the doxorubicin was fixed inside the nanoparticles. The dextran shell makes the nanoparticles dispersible in solution. The nanoparticles have a spherical morphology and a hydrodynamic radius of about 90 nm. Importantly, the nanoparticles can significantly prolong the life of murine ascites hepatoma H22 tumor-bearing mice.
Deng
Wei
W
Key Laboratory of Molecular Engineering of Polymer and Department of Macromolecular Science, Fudan University, Shanghai, China.
Li
Juan
J
Yao
Ping
P
He
Fen
F
Huang
Chong
C
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D003911:Dextrans / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D055772:Green Chemistry Technology; D006358:Hot Temperature; D015416:Maillard Reaction; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D003911:Dextrans; D004337:Drug Carriers; C043578:bovine serum albumin-dextran conjugate; D012710:Serum Albumin, Bovine; D004317:Doxorubicin