title: Optimal fosamprenavir regimen to prevent lipid abnormalities.
abstract: We report our experience on the impact of different fosamprenavir boosted regimens on plasma lipid levels in 48 naive monoinfectd- HIV-seropositive patients. Eighteen months after starting antiretroviral therapy (ART), all patients showed a good immuno-virological response, with no statistically significant differences among the three groups; no changes in ART regimens were necessary and no adverse events were reported. On the contrary, a statistically significant difference among the three groups of patients was observed in cholesterol and triglyceride levels, since higher levels of cholesterol (including LDLs) and triglycerides were observed in patients taking the higher dose of ritonavir. (www.actabiomedica.it)
authors.affiliation: Infectious Disease Unit, G.B. Rossi Hospital, Verona, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Lattuada
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Lanzafame
authors.forename: Carmela
authors.initials: C
authors.lastname: Grosso
authors.forename: Fabio
authors.initials: F
authors.lastname: Soldani
authors.forename: Fabiana
authors.initials: F
authors.lastname: Corsini
authors.forename: Silvia
authors.initials: S
authors.lastname: Storato
authors.forename: Sandro
authors.initials: S
authors.lastname: Vento
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002219:Carbamates / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005663:Furans; D017320:HIV Protease Inhibitors / Q000008:administration & dosage; D006679:HIV Seropositivity / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D010755:Organophosphates / Q000008:administration & dosage*; D019438:Ritonavir / Q000008:administration & dosage; D013449:Sulfonamides / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
chemical_list: D019380:Anti-HIV Agents; D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D010755:Organophosphates; D013449:Sulfonamides; D014280:Triglycerides; D019438:Ritonavir; C426859:fosamprenavir