New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern).
Two new 5-methylcoumarin glycosides named diosfeboside A (1) and B (2) and five known compounds namely kaempferol 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (3), ursolic acid (4), betulinic acid (5), stigmasterol (6) and stigmasterol 3-O-β-D-glucopyranoside (7) were isolated from the leaves of Diospyros crassiflora (Hiern). Their structures were established through interpretation of 1 and 2D NMR, mass spectra analysis and comparison with reported data. In vitro cytotoxic activity of the new compounds against human carcinoma cell lines (HL-60, Bel-7402, BGC-823, and KB) was evaluated and no cytotoxicity was observed for each of them.
Akak
Carine Mvot
CM
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box: 812, Yaounde, Cameroon. mvotcarine@yahoo.fr
Djama
Céline Mbazoa
CM
Nkengfack
Augustin Ephrem
AE
Tu
Peng-Fei
PF
Lei
Lian-Di
LD
D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029788:Diospyros / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves
D003374:Coumarins; D006027:Glycosides; D010936:Plant Extracts; C557370:diosfeboside A; C557371:diosfeboside B