Clinical and histologic response to methylprednisolone pulse therapy in glomerulonephritis.
We retrospectively analyzed the data of the first and second renal biopsies to investigate the adverse effects as well as the clinical and histologic responses of methylprednisolone pulse therapy in patients with chronic glomerulonephritis. At the time of the second renal biopsy, the activity index had decreased significantly and the chronicity index was well preserved. The activity index and interstitial fibrosis were improved in the complete and partial remission groups, but not in the nonresponse group. These findings indicate that methylprednisolone pulse therapy is effective in patients with chronic glomerulonephritis and has an acceptably low risk of side effects.
Cho
Byoung-Soo
BS
Department of Pediatrics, Kyung Hee University, Seoul, Korea. bscho@dreamwiz.com
Park
Sung-Shin
SS
Kim
Sung-Do
SD
Won
Kyu Yeoun
KY
Lim
Sung-Jig
SJ
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D020551:Pulse Therapy, Drug; D012189:Retrospective Studies; D016896:Treatment Outcome
D005938:Glucocorticoids; D008775:Methylprednisolone