[Malformation syndromes associated with childhood cancer: an update].
Biology, genetics and environment of childhood solid tumours set them apart from adult solid tumours. The nature of the progenitor cells from which these tumours arise, and their immature tissue environment, allows childhood solid tumours to develop with fewer defects in cell regulatory processes. Constitutional molecular defects are known to play a role in childhood solid tumours, as shown by the increased incidence of embryonic cancers in children carrying malformations associated with childhood cancer. These rare diagnoses are commonly missed. In this article, we reviewed the spectrum of these tumour predisposition syndromes.
de Pontual
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Service de pédiatrie, hôpital Jean-Verdier, AP-HP, université Paris XIII, 14, avenue du 14-Juillet, 93143 Bondy, France. loic.de-pontual@jvr.aphp.fr
Lyonnet
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Amiel
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D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000145:classification*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000196:embryology / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics