Catheter-related bacteremia caused by methicillin-resistant coagulase negative staphylococci with elevated minimal inhibitory concentration for vancomycin.
Treatment of bacteremia caused by methicillin-resistant coagulase-negative staphylococci with vancomycin minimum inhibitory concentration ≥2 mg/L frequently requires central venous catheter removal in children with cancer. There are few data supporting efficacy and safety of antibiotic catheter lock or use of daptomycin or linezolid for this indication in children.
Castagnola
Elio
E
Infectious Diseases Unit, Department of Hematology and Oncology, G. Gaslini Children's Hospital, Genoa, Italy. eliocastagnola@opsedale-gaslini.ge.it
Bandettini
Roberto
R
Lorenzi
Ines
I
Caviglia
Ilaria
I
Macrina
Gianni
G
Tacchella
Angela
A
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling; D016009:Chi-Square Distribution; D002648:Child; D003030:Coagulase / Q000378:metabolism; D017576:Daptomycin / Q000494:pharmacology; D006801:Humans; D000069349:Linezolid; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology; D011446:Prospective Studies; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014640:Vancomycin / Q000008:administration & dosage* / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D003030:Coagulase; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D017576:Daptomycin