title: Alternative and complementary therapies for the menopause.
abstract: The use of complementary and alternative medicine (CAM) among menopausal women has increased in the last years. This review examines the evidence from systematic reviews, RCTs and epidemiological studies of CAM in the treatment of menopausal symptoms. Some evidence exists in favour of phytosterols and phytostanols for diminishing LDL and total cholesterol in postmenopausal women. Similarly, regular fiber intake is effective in reducing serum total cholesterol in hypercholesterolemic postmenopausal women. Clinical evidence also exists on the effectiveness of vitamin K, a combination of calcium and vitamin D or a combination of walking with other weight-bearing exercise in reducing bone mineral density loss and the incidence of fractures in postmenopausal women. Black cohosh appears to be effective therapy for relieving menopausal symptoms, primarily hot flashes, in early menopause. Phytoestrogen extracts, including isoflavones and lignans, appear to have only minimal effect on hot flashes but have other positive health effects, e.g. on plasma lipid levels and bone loss. For other commonly used CAMs, e.g. probiotics, prebiotics, acupuncture, homeopathy and DHEA-S, randomized, placebo-controlled trials are scarce and the evidence is unconvincing. More and better RCTs testing the effectiveness of these treatments are needed.
authors.affiliation: Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. franborr@unina.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Borrelli
authors.forename: Edzard
authors.initials: E
authors.lastname: Ernst
mesh_terms: D000529:Complementary Therapies; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D006937:Hypercholesterolemia / Q000628:therapy*; D008593:Menopause; D015663:Osteoporosis, Postmenopausal / Q000628:therapy*; D008517:Phytotherapy