Development of factor V and thrombin inhibitors in children following bovine thrombin exposure during cardiac surgery: a report of three cases.
Factor V and thrombin inhibitors may develop following exposure to bovine thrombin preparations. In patient populations where exposure to bovine thrombin is common, such as children undergoing cardiovascular surgery, the development of such inhibitors should be considered in the evaluation of prolonged prothrombin times. We present three cases of children developing factor V and thrombin inhibitors following repeated exposure during cardiac surgical procedures.
Bomgaars
Lisa
L
Department of Pediatrics, Hematology-Oncology Section, Baylor College of Medicine, Houston, TX 77030, USA. lbomgaars@txccc.org
Carberry
Kathleen
K
Fraser
Charles
C
West
Aaron
A
Teruya
Jun
J
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D006348:Cardiac Surgical Procedures; D002417:Cattle; D002675:Child, Preschool; D005165:Factor V / Q000037:antagonists & inhibitors*; D005260:Female; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013917:Thrombin / Q000009:adverse effects* / Q000037:antagonists & inhibitors*
D019774:Blood Coagulation Factor Inhibitors; D006490:Hemostatics; D005165:Factor V; D013917:Thrombin