title: Clinical and economic burden of pneumococcal disease in older US adults.
abstract: We developed a model characterizing rates and costs of pneumococcal disease in the US to estimate the expected annual clinical and economic burden of this condition among older adults. Among the 91.5 million US adults aged >or=50 years, 29,500 cases of invasive pneumococcal disease, 502,600 cases of nonbacteremic pneumococcal pneumonia, and 25,400 pneumococcal-related deaths are estimated to occur yearly; annual direct and indirect costs are estimated to total $3.7 billion and $1.8 billion, respectively. Pneumococcal disease remains a substantial burden among older US adults, despite increased coverage with PPV23 and indirect benefits afforded by PCV7 vaccination of young children.
authors.affiliation: Policy Analysis Inc. (PAI), Brookline, MA 02445, United States. dweycker@pai2.com
authors.forename: Derek
authors.initials: D
authors.lastname: Weycker
authors.forename: David
authors.initials: D
authors.lastname: Strutton
authors.forename: John
authors.initials: J
authors.lastname: Edelsberg
authors.forename: Reiko
authors.initials: R
authors.lastname: Sato
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Jackson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017281:Cost of Illness; D003365:Costs and Cost Analysis / Q000191:economics; D005102:Health Expenditures; D006801:Humans; D008875:Middle Aged; D018803:Models, Economic; D011008:Pneumococcal Infections / Q000191:economics* / Q000453:epidemiology; D014481:United States / Q000453:epidemiology