title: Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression.
abstract: The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis. On Opisthorchis viverrini infection treated with dietary curcumin apoptosis-related gene expression profiles were similar to O. viverrini-infected group, but the expression levels seemed lower. Light microscopic observation revealed that aggregation of inflammatory cells surrounding the hepatic bile ducts in the groups infected with O. viverrini and treated with dietary curcumin was lower than in infected group. The intensity of the response is correlated with expression of the genes studied. The results suggest that curcumin reduces pathogenesis in hamster-opisthorchiasis by controlling apoptosis-related gene expression.
authors.affiliation: Faculty of Medical Technology, Rangsit University, Pathum Thani.
authors.forename: Pranee
authors.initials: P
authors.lastname: Sriraj
authors.forename: Thidarut
authors.initials: T
authors.lastname: Boonmars
authors.forename: Sirintip
authors.initials: S
authors.lastname: Boonjaraspinyo
authors.forename: Butsara
authors.initials: B
authors.lastname: Kaewsamut
authors.forename: Tuanchai
authors.initials: T
authors.lastname: Srisawangwong
authors.forename: Paiboon
authors.initials: P
authors.lastname: Sithithaworn
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics*; D006224:Cricetinae; D003474:Curcumin / Q000494:pharmacology*; D015870:Gene Expression; D008297:Male; D009889:Opisthorchiasis / Q000188:drug therapy* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D003474:Curcumin