title: [Indicators of innate and adaptive immunity of cosmonauts after long-term space flight to international space station].
abstract: Results of innate and adaptive immunity indicators research at 12 cosmonauts who took part in long (128-215 days) expeditions to the International space station (ISS) are presented. It is shown that a space flight can lead to deflection of deviations in human immune system. These shifts occurred in decrease of phagocytes, NK, T-lymphocytes functional activity and also in abilities of immunocompetent cells to synthesize cytokines. Significant individual changes are noted in reaction of immune system to the long term space flight conditions specifying on individual predisposition to development of immune reactance infringements in the conditions of varying gravitational influences.
authors.forename: V B
authors.initials: VB
authors.lastname: Morukov
authors.forename: M P
authors.initials: MP
authors.lastname: Rykova
authors.forename: E N
authors.initials: EN
authors.lastname: Antropova
authors.forename: T A
authors.initials: TA
authors.lastname: Berendeeva
authors.forename: S A
authors.initials: SA
authors.lastname: Ponomarev
authors.forename: I M
authors.initials: IM
authors.lastname: Larina
mesh_terms: D056704:Adaptive Immunity; D016207:Cytokines / Q000276:immunology; D018470:Gravity, Altered / Q000009:adverse effects*; D006801:Humans; D007113:Immunity, Innate; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D010586:Phagocytes / Q000276:immunology*; D013026:Space Flight; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
chemical_list: D016207:Cytokines