Comparative genome analysis of Prevotella ruminicola and Prevotella bryantii: insights into their environmental niche.
The Prevotellas comprise a diverse group of bacteria that has received surprisingly limited attention at the whole genome-sequencing level. In this communication, we present the comparative analysis of the genomes of Prevotella ruminicola 23 (GenBank: CP002006) and Prevotella bryantii B(1)4 (GenBank: ADWO00000000), two gastrointestinal isolates. Both P. ruminicola and P. bryantii have acquired an extensive repertoire of glycoside hydrolases that are targeted towards non-cellulosic polysaccharides, especially GH43 bifunctional enzymes. Our analysis demonstrates the diversity of this genus. The results from these analyses highlight their role in the gastrointestinal tract, and provide a template for additional work on genetic characterization of these species.
Purushe
Janaki
J
Department of Human Genomic Medicine, The J. Craig Venter Institute (JCVI), Rockville, MD 20850, USA. jpurushe@jcvi.org
Fouts
Derrick E
DE
Morrison
Mark
M
White
Bryan A
BA
Mackie
Roderick I
RI
Coutinho
Pedro M
PM
Henrissat
Bernard
B
Nelson
Karen E
KE
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010802:Phylogeny; D018720:Prevotella / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D045243:Prevotella ruminicola / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D012417:Rumen / Q000382:microbiology
D001426:Bacterial Proteins