Evidence for recombination between vaccine and wild-type mumps virus strains.
Recombination of mumps virus (MuV) has rarely been reported. In this study, phylogenetic and recombination analyses were performed on 30 complete MuV genomes, including 17 vaccine and 13 wild-type strains. One potentially significant recombination event was found to have occurred between the lineage represented by the vaccine strain L3/Russia/Vector (AY508995) as the minor parent and wild MuV strain Drag94 (AY669145) as the major parent, and this led to a recombinant, 9218/Zg98 (EU370206), a wild-type MuV strain isolated from a 3-year-old boy with parotitis. In summary, we found a recombinant of MuV derived from vaccine and wild-type MuV strains.
Zhang
Wen
W
School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China. z0216wen@yahoo.com
Liu
Wei
W
D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D009107:Mumps / Q000517:prevention & control / Q000821:virology*; D009108:Mumps Vaccine / Q000235:genetics* / Q000302:isolation & purification; D009109:Mumps virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D011995:Recombination, Genetic
D009108:Mumps Vaccine