title: Persistently folded circular aromatic amide pentamers containing modularly tunable cation-binding cavities with high ion selectivity.
abstract: In this work, we illustrated a novel design strategy that allows systematically tunable interior properties (effective cavity size, steric crowdedness, and hydrophobicity) contained within a novel class of shape-persistent aromatic pentamers to take place on a scale below 3 A. Such finely tunable structural features are complimented by experimentally observable functional variations in ion-binding potential. Results of the selective, differential binding affinities of three circular pentamers for Li(+), Na(+), K(+), Rb(+), and Cs(+), substantiated by metal-containing crystal structures and computational modeling, are detailed.
authors.affiliation: Department of Chemistry, 3 Science Drive 3, National University of Singapore, Singapore 117543.
authors.forename: Bo
authors.initials: B
authors.lastname: Qin
authors.forename: Changliang
authors.initials: C
authors.lastname: Ren
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Ye
authors.forename: Chang
authors.initials: C
authors.lastname: Sun
authors.forename: Khalid
authors.initials: K
authors.lastname: Chiad
authors.forename: Xiuying
authors.initials: X
authors.lastname: Chen
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.forename: Haibin
authors.initials: H
authors.lastname: Su
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Chass
authors.forename: Huaqiang
authors.initials: H
authors.lastname: Zeng
mesh_terms: D000577:Amides / Q000737:chemistry*; D002412:Cations; D018360:Crystallography, X-Ray; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D000577:Amides; D002412:Cations; D008670:Metals