title: Time-resolved diffuse optical tomography with patterned-light illumination and detection.
abstract: This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.
authors.affiliation: Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.forename: Vivek
authors.initials: V
authors.lastname: Venugopal
authors.forename: Frederic
authors.initials: F
authors.lastname: Lesage
authors.forename: Xavier
authors.initials: X
authors.lastname: Intes
mesh_terms: D021621:Imaging, Three-Dimensional; D008029:Lighting / Q000379:methods*; D019047:Phantoms, Imaging; D013997:Time Factors; D041622:Tomography, Optical / Q000379:methods*