title: Anaplastic variant of clear cell sarcoma of the kidney: a rare case report.
abstract: Clear cell sarcoma (CCSK) of the kidney is an uncommon but distinctive pediatric renal tumor with a characteristic histological pattern and marked propensity for bone metastasis. The rare anaplastic variant constitutes about 3% of cases of CCSK and carries an unfavorable prognosis, with increased tumor recurrence and resistant to chemotherapy. This variant show high frequency of p53 gene mutation and p53 over expression in comparison to the usual CCSK. We present a case of anaplastic variant of CCSK in an 10-year-old boy with both cytologic and histologic features, highlighting the importance of recognizing this rare entity.
authors.affiliation: Department of Pathology, AIIMS, New Delhi, India: mk3aiims@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Kukreja
authors.forename: M
authors.initials: M
authors.lastname: Kamal
authors.forename: V K
authors.initials: VK
authors.lastname: Iyer
authors.forename: A A S R
authors.initials: AA
authors.lastname: Mannan
authors.forename: S
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D002648:Child; D016158:Genes, p53; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D018227:Sarcoma, Clear Cell / Q000473:pathology*