Preclinical photoacoustic imaging endoscope based on acousto-optic coaxial system using ring transducer array.
We developed and fabricated a preclinical photoacoustic imaging endoscope (PAIE) with an acousto-optic coaxial structure for cavity imaging that integrates a Plexiglas tube, an optical fiber, a ring transducer array, a taper reflector, and an ultrasonic coupling medium. A photoacoustic image for a section of pig colorectal tissue embedded in a transparent gelatin phantom was reconstructed. Furthermore, human colorectal cancer and normal colorectal tissue were imaged ex vivo with a contrast ratio of approximately 2.3. Experimental results demonstrate that the PAIE has potential for detecting colorectal cancer in clinical use.
Yuan
Yi
Y
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Yang
Sihua
S
Xing
Da
D
D000162:Acoustics; D000818:Animals; D003106:Colon / Q000166:cytology / Q000473:pathology; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology; D019723:Endoscopes; D006801:Humans; D055620:Optical Phenomena; D012007:Rectum / Q000166:cytology / Q000473:pathology; D014159:Transducers