title: Back to basics for idiosyncratic drug-induced liver injury: dose and metabolism make the poison.
abstract: Two studies show that the risk of drug-induced liver injury (DILI) is increased when the daily dose of a drug given by oral route is higher than 10mg per day and/or when the drug undergoes a significant hepatic metabolism. If confirmed, these data suggest that developing drugs with high potency and low hepatic metabolism will reduce the risk of idiosyncratic DILI in man.
authors.affiliation: Sanofi-aventis R&D, 91385 Chilly-Mazarin, France. francois.ballet@sanofi-aventis.com
authors.forename: F
authors.initials: F
authors.lastname: Ballet