title: [Comparative study on pharmacokinetics of tetramethylpyrazine, ferulic acid and their compatibility].
abstract: OBJECTIVE
  To study the pharmacokinetics of tetramethylpyrazine (TMP), ferulic acid and their compatibility.
  
  
  METHODS
  Twenty-four Sprague-Dawley rats were randomly divided into 3 groups: TMP 20 mg x kg(-1), ferulic acid 20 mg x kg(-1) and TMP 20 mg x kg(-1) + ferulic acid 20 mg x kg(-1). All the rats were given intragastric administration then blood samples were obtained from fossa orbitalis at several time points. All the plasmas concentrations were analyzed by HPLC method and the data were treated by DAS 2.0 program.
  
  
  RESULTS
  The main pharmacokinetics parameters of TMP 20 mg x kg(-1) group, ferulic acid 20 mg x kg(-1) and TMP 20 mg x kg(-1) + ferulic acid 20 mg x kg(-1) were as follows: t(max) 0.5 h, t1/2 0.856 h,MRT 1.321 h, AUC 5.112 microg x h(-1) x L(-1), C(max) 2.834 microg x L(-1); t(max) 0.083 h, t1/2 1.024 h, MRT 1.324 h, AUC 1.581 microg x h(-1) x L(-1), C(max) 1.492 microg x L(-1); t(max) 0.583 h, t1/2 37.901 h, MRT 3.798 h, AUC 4.097 microg x h(-1) x L(-1), C(max)1.571 microg x L(-1); t(max) 0.6 h, t1/2 7.860 h, MRT 2.894 h, AUC 1.984 microg x h(-1) x L(-1), C(max) 1.03 microg x L(-1), respectively.
  
  
  CONCLUSIONS
  The experiments suggested that the compatibility of TMP and ferulic acid had interaction in pharmacokinetics; all the t1/2 and MRT were prolonged and had the effect of lente liberates.
authors.affiliation: Southwest University, Chongqing 400716, China. fbb200596@126.com
authors.forename: Binbin
authors.initials: B
authors.lastname: Feng
authors.forename: Jianhai
authors.initials: J
authors.lastname: Zhang
authors.forename: Jifen
authors.initials: J
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Xu
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002138:Calibration; D003373:Coumaric Acids / Q000493:pharmacokinetics*; D005260:Female; D016014:Linear Models; D011719:Pyrazines / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results
chemical_list: D003373:Coumaric Acids; D011719:Pyrazines; C004999:ferulic acid; C017953:tetramethylpyrazine