title: Suppression of melatonin secretion in healthy subjects with eyeglass LED delivery system.
abstract: OBJECTIVE
  Practicability remains a problem in light therapy of biological rhythm disorders. We report here the effect on melatonin secretion of a device consisting of a prototype of eyeglasses including light emitting diodes (LED) in lenses (Somnavue).
  
  
  METHODS
  Light (1,200 lx) was administered in a randomised crossover design to ten healthy subjects with Somnavue for 1 or 2 hours, Lumino (a helmet which administers light) for 1 hour, and placebo, beginning at 01:00 h. Plasma melatonin concentrations were evaluated between 20:00-05:00 h.
  
  
  RESULTS
  Multiple comparisons showed differences between placebo and Somnavue administered for one or two hours (p<0.01 and p<0.05 respectively) and Lumino and placebo (p<0.05).
  
  
  CONCLUSIONS
  In conclusion, Somnavue was able to suppress melatonin. The development of such a device could increase adherence with light treatment in SAD or circadian rhythm sleep disorders.
authors.affiliation: INSERM, U846, Bron, France. bruno.claustrat@chu-lyon.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Claustrat
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Brun
authors.forename: Françoise
authors.initials: F
authors.lastname: Borson-Chazot
authors.forename: Denis
authors.initials: D
authors.lastname: Cohen-Tannoudji
authors.forename: Francine
authors.initials: F
authors.lastname: Claustrat
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Julien
authors.forename: Patrick
authors.initials: P
authors.lastname: Lemoine
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D004735:Energy Transfer; D006801:Humans; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D010775:Photic Stimulation / Q000295:instrumentation*; D010789:Phototherapy / Q000295:instrumentation
chemical_list: D008550:Melatonin