title: Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans?
abstract: OBJECTIVE
  To undertake a preliminary assessment of the prevalence of CYP2C19 ultra-rapid and poor metaboliser genetic variants in Pacific people compared with NZ Europeans.
  
  
  METHODS
  Individuals who self-identified as either Pacific people (n=14) or NZ European (n=12) were genotyped for the *2, *3 or *17 functional variants of CYP2C19.
  
  
  RESULTS
  There was a significantly lower frequency (P<0.01) of the CYP2C19*17 allele in Pacific people compared with NZ Europeans. No CYP2C19*17 variant alleles were detected in Pacific people in this preliminary study.
  
  
  CONCLUSIONS
  The presence of CYP2C19*17 may be low in Pacific people and may lead to altered efficiency at metabolising some common drugs such as omeprazole. Further studies to confirm this preliminary finding are warranted.
authors.affiliation: Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. n.helsby@auckland.ac.nz
authors.forename: Nuala
authors.initials: N
authors.lastname: Helsby
authors.forename: Michael
authors.initials: M
authors.lastname: Goldthorpe
authors.forename: Peter
authors.initials: P
authors.lastname: Gow
authors.forename: Janak
authors.initials: J
authors.lastname: de Zoysa
mesh_terms: D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065731:Cytochrome P-450 CYP2C19; D004247:DNA / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics; D005060:Europe / Q000208:ethnology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008181:Lupus Nephritis / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D009520:New Zealand / Q000453:epidemiology; D009853:Omeprazole / Q000493:pharmacokinetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence
chemical_list: D004791:Enzyme Inhibitors; D004247:DNA; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D009853:Omeprazole