title: Continuous and intermittent CSF diversion after subarachnoid hemorrhage: a pilot study.
abstract: BACKGROUND
  We examine two accepted methods of managing cerebrospinal fluid (CSF) drainage in patients following subarachnoid hemorrhage (SAH). The first is intermittent CSF drainage when intracranial pressure (ICP) reaches a pre-defined threshold (monitor-first) and the second is continuous CSF drainage (drain-first) at set pressure thresholds. This pilot study is designed to determine if there is a cause for a randomized study of comparing the two methods.
  
  
  METHODS
  This prospective observational pilot study enrolled 37 patients with SAH and external ventricular drainage between October 2008 and August 2009. Patients were treated with one of two methods of ICP management (drain-first vs. monitor-first) according to the discretion of the admitting physician.
  
  
  RESULTS
  There were no significant differences in baseline characteristics including age, gender, severity of neurological dysfunction, and radiographic findings between the two groups. The incidence of vasospasm was not different between the drain-first group (66.7%; 16 of 24 patients) and the monitor-first group (53.9%; 7 of 13 patients).
  
  
  CONCLUSIONS
  This pilot study was neither powered, nor expected to detect a difference between groups. The results of this study provide support for the design and conduct of a randomized study to assess the impact of two methods of CSF diversion for patients with SAH.
authors.affiliation: Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Koyang, Korea.
authors.forename: G S
authors.initials: GS
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Amato
authors.forename: M L
authors.initials: ML
authors.lastname: James
authors.forename: G W
authors.initials: GW
authors.lastname: Britz
authors.forename: A
authors.initials: A
authors.lastname: Zomorodi
authors.forename: C
authors.initials: C
authors.lastname: Graffagnino
authors.forename: M
authors.initials: M
authors.lastname: Zomorodi
authors.forename: DaiWai M
authors.initials: DM
authors.lastname: Olson
mesh_terms: D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects / Q000379:methods*; D003422:Critical Care / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015994:Incidence; D019586:Intracranial Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010865:Pilot Projects; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology / Q000628:therapy*; D020301:Vasospasm, Intracranial / Q000453:epidemiology