Effect of gastroesophageal reflux disease on sleep.
Recent studies have demonstrated a bidirectional relationship between gastroesophageal reflux disease (GERD) and sleep where night-time reflux leads to sleep deprivation and sleep deprivation per se can exacerbate GERD by enhancing perception of intra-esophageal stimuli. Presently, treatment has primarily focused on reducing night-time reflux and thus improving sleep quality. Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between GERD and sleep.
Fass
Ronnie
R
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona School of Medicine, Tucson, Arizona 85723-0001, USA. ronnie.fass@va.gov
D013505:Digestive System Surgical Procedures; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D018570:Risk Assessment; D012307:Risk Factors; D012890:Sleep; D012893:Sleep Wake Disorders / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
D054328:Proton Pump Inhibitors