The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids.
The cytochrome P-450 1A1 (CYPA1A) gene plays an important role in the metabolization of estrogen and is therefore a candidate marker for fibroids. In a case-control study, we were unable to demonstrate any association between MSP I CYP1A1 polymorphism and the risk of leiomyoma in Brazilian women.
Barão
Marco Antônio
MA
Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
Oliveira
Emerson
E
Gomes
Mariano Tamura Vieira
MT
da Silva
Ismael Dale Cotrim Guerreiro
ID
Sartori
Marair Gracio Ferreira
MG
Girão
Manoel João Batista Castello
MJ
Castro
Rodrigo de Aquino
Rde A
D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000502:physiology; D019003:Deoxyribonuclease HpaII / Q000378:metabolism; D004958:Estradiol / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000235:genetics; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics / Q000502:physiology*; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000097:blood / Q000235:genetics* / Q000378:metabolism
D004958:Estradiol; D019363:Cytochrome P-450 CYP1A1; D019003:Deoxyribonuclease HpaII