title: Nodular regenerative hyperplasia of the liver secondary to azathioprine in a patient with inflammatory bowel disease.
abstract: A case of dramatic portal hypertension with massive ascites and splenomegaly is described in a patient with inflammatory bowel disease receiving azathioprine therapy. Liver biopsy confirmed the subtle changes of nodular regenerative hyperplasia and the patient recovered following withdrawal of the azathioprine and commencement of spironolactone. Thrombocytopaenia is an early clue to azathioprine-induced nodular regenerative hyperplasia of the liver.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Bryant
authors.forename: Carina J
authors.initials: CJ
authors.lastname: Miles
authors.forename: Richard B
authors.initials: RB
authors.lastname: Gearry
mesh_terms: D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000175:diagnosis; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine