title: Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters.
abstract: Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV-infected patients than that in controls (P = 0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (rho = 0.76, P < 0.0001), fasting glucose (rho = 0.41, P = 0.001) and insulin (rho = 0.44, P = 0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients.
authors.affiliation: Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. jlo@partners.org
authors.forename: Janet
authors.initials: J
authors.lastname: Lo
authors.forename: Suhny
authors.initials: S
authors.lastname: Abbara
authors.forename: Jose A
authors.initials: JA
authors.lastname: Rocha-Filho
authors.forename: Leon
authors.initials: L
authors.lastname: Shturman
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wei
authors.forename: Steven K
authors.initials: SK
authors.lastname: Grinspoon
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D001823:Body Composition; D003324:Coronary Artery Disease / Q000473:pathology* / Q000821:virology; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors