title: Early diffuse demyelinating lesion in the cervical spinal cord predicts a worse prognosis in relapsing-remitting multiple sclerosis.
abstract: OBJECTIVE
  To study the long-term outcome and persistence of two patterns of cervical spinal cord abnormality in early relapsing-remitting multiple sclerosis (RRMS).
  
  
  METHODS
  RRMS patients with a spinal cord MRI performed during the first 3 years of the disease, a control MRI 5 years later and who have been followed up at least 10 years were included. Patients were grouped according the T2 spinal cord MRI into: (A) nodular pattern, if one or more focal lesions were present; and (B) diffuse pattern, defined as a poorly demarcated high signal area. The end point was defined as the time to reach an Expanded Disability Status Score (EDSS) of 4.0.
  
  
  RESULTS
  Twenty-five patients were included; 12 in group A and 13 in group B. Three patients in group A and 9 in group B reached EDSS 4, in a mean time of 11 years in group A and 7 years in group B (log rank 10.3, p = 0.001). Multivariate Cox regression analysis assessing the risk of EDSS 4.0 including sex, age, number of relapses in the first 2 years, number of T2 brain lesions and spinal cord pattern showed higher risk for the diffuse pattern (hazard ratio 7.2, 95% confidence interval 1.4-36.4). Control MRI showed the persistence of the diffuse pattern in all patients, and the development of diffuse pattern in two patients with basal nodular lesions.
  
  
  CONCLUSIONS
  The diffuse abnormality in cervical spinal cord at the beginning of the disease is persistent and predicts a worse prognosis in RRMS patients.
authors.affiliation: Neurology Service, Clinic University Hospital, Valencia, Spain. coret_fra@gva.es
authors.forename: F
authors.initials: F
authors.lastname: Coret
authors.forename: I
authors.initials: I
authors.lastname: Bosca
authors.forename: L
authors.initials: L
authors.lastname: Landete
authors.forename: M J
authors.initials: MJ
authors.lastname: Magraner
authors.forename: A
authors.initials: A
authors.lastname: Navarré
authors.forename: J L
authors.initials: JL
authors.lastname: León
authors.forename: B
authors.initials: B
authors.lastname: Casanova
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology / Q000503:physiopathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D013116:Spinal Cord / Q000473:pathology*; D055815:Young Adult