title: [Gastroprotective properties of mexidol and hypoxen].
abstract: Experimental damage in the stomach mucosa of test rats was modeled by acetylsalicylic acid (aspirin-induced ulcerogenesis). The number of ulcers and the total area of erosive injury in the mucous membrane were studied. Prophylactic treatment with mexidol and hypoxen in a daily dose of 50 mg/kg reduces the aspirin-induced damage of stomach mucosa. The gastroprotective properties of drugs are probably related to their antioxidant and antihypoxant effects.
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: N O
authors.initials: NO
authors.lastname: Kriukova
authors.forename: A S
authors.initials: AS
authors.lastname: Novikov
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants / Q000627:therapeutic use*; D001241:Aspirin; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D010647:Phenyl Ethers / Q000627:therapeutic use*; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D010647:Phenyl Ethers; D010847:Picolines; C085806:olifen; C070020:emoxypine succinate; D001241:Aspirin