title: Efficacy of intramuscular clodronate in Complex Regional Pain Syndrome type I: description of a case located in the astragalus in a patient with psoriatic arthritis.
abstract: Reflex sympathetic dystrophy or Complex Regional Pain Syndrome type I (CRPS I) is a painful regional disease with non-metameric topography, which shows extreme pathomorphological variability, from forms in which pain is the only clinical manifestation, to "pseudo-purulent" forms characterized by impressive local manifestations. The use of high doses of bisphosphonates in the treatment of CRPS I is confirmed in different publications which associate their efficacy with their specific biological properties and multiple actions at local level. This case report describes a case of CRPS I in the astragalus of a patient with psoriatic arthritis, successfully treated with intramuscular clodronate.
authors.affiliation: Rheumatology Branch, Specialist Outpatients' Department, Belluno, Italy. cassisi.agordo@libero.it
authors.forename: Gianniantonio
authors.initials: G
authors.lastname: Cassisi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sartori
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000453:epidemiology*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004002:Clodronic Acid / Q000627:therapeutic use*; D015897:Comorbidity; D006801:Humans; D007273:Injections, Intramuscular; D008279:Magnetic Resonance Imaging; D008297:Male; D011877:Radionuclide Imaging; D012019:Reflex Sympathetic Dystrophy / Q000188:drug therapy* / Q000453:epidemiology*; D013628:Talus / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D050071:Bone Density Conservation Agents; D004002:Clodronic Acid