title: Liver transplantation in a patient with pulmonary hypertension at high altitude.
abstract: Chronic hypoxia at high altitude stresses many of the body's homeostatic mechanisms. As a consequence, the body develops alveolar hypoxia, hypoxemia, and polycythemia, which in turn causes vasoconstriction, pulmonary hypertension, and an increased risk of atherothrombotic complications. We report a successful liver transplantation in a patient with pulmonary hypertension who lives 4500 m above sea level. Pulmonary hypertension and hypercoagulable state induced by chronic hypoxia at high altitude may increase the risk of cardiopulmonary complication and perioperative mortality. The patient was discharged in good condition with normal liver function at the 34th postoperative day. After 41 months of follow-up, the patient is alive and well with a continued normalization of hepatic function and is continuing to live at 4500 m above sea level.
authors.affiliation: Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi Province, China. hepato@fmmu.edu.cn
authors.forename: Kefeng
authors.initials: K
authors.lastname: Dou
authors.forename: Desheng
authors.initials: D
authors.lastname: Wang
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
authors.forename: Zhenshun
authors.initials: Z
authors.lastname: Song
authors.forename: Shuqiang
authors.initials: S
authors.lastname: Yue
authors.forename: Kaishan
authors.initials: K
authors.lastname: Tao
authors.forename: Shaoyang
authors.initials: S
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Ti
mesh_terms: D000531:Altitude; D001777:Blood Coagulation / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000628:therapy*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome