title: Echocardiographic determinants of the clinical condition in patients with a systemic right ventricle.
abstract: BACKGROUND
  Ventricular systolic and diastolic function, as measured by echocardiography, are diminished in patients with a systemic right ventricle (RV). As the clinical implications of these finding remained unknown, we aimed to identify echocardiographic parameters of systolic and diastolic ventricular function that are independent determinants of the clinical condition in these patients.
  
  
  METHODS
  Forty-six adult patients (61% male; mean age 33 [range 18-69] years) with a systemic RV underwent echocardiography to assess qualitative and quantitative systolic and diastolic function of the systemic RV and the subpulmonary left ventricle (LV). Uni- and multivariate linear regression analyses were performed to identify independent echocardiographic determinants for NYHA class, maximal exercise capacity (V'O(2peak)) and NT-proBNP levels.
  
  
  RESULTS
  We found qualitative assessment of RV and LV function to be significantly associated with NYHA class (RV: β= 0.26; P = 0.05 and LV: β= 0.82; P < 0.01), V'O(2peak) (RV: β=-10.4; P < 0.05 and LV: β=-18.4; P < 0.05) and NT-proBNP levels (RV: β= 0.58; P < 0.01 and LV: β= 1.40; P < 0.001). Tricuspid annulus plane systolic excursion (TAPSE) was significantly associated with NYHA class (β=-0.92; P = 0.001), V'O(2peak) (β= 18.5; P = 0.05), and serum NT-proBNP levels (β=-1.00; P < 0.05). Associations between quantitative parameters of systolic subpulmonary LV function and clinical parameters were less distinct. We found no associations between RV and LV diastolic function and clinical parameters.
  
  
  CONCLUSIONS
  Qualitative function of the systemic RV and the subpulmonary LV, and TAPSE, are determinants of clinical condition in patients with a systemic RV. These patients' clinical condition could not be determined by echocardiographically measured diastolic RV function, and systolic and diastolic LV function.
authors.affiliation: Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Michiel M
authors.initials: MM
authors.lastname: Winter
authors.forename: Berto J
authors.initials: BJ
authors.lastname: Bouma
authors.forename: Maxim
authors.initials: M
authors.lastname: Hardziyenka
authors.forename: Rianne H A C M
authors.initials: RH
authors.lastname: De Bruin-Bon
authors.forename: Hanno L
authors.initials: HL
authors.lastname: Tan
authors.forename: Thelma C
authors.initials: TC
authors.lastname: Konings
authors.forename: Arie P J
authors.initials: AP
authors.lastname: Van Dijk
authors.forename: Barbara J M
authors.initials: BJ
authors.lastname: Mulder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging*; D018497:Ventricular Dysfunction, Right / Q000150:complications* / Q000000981:diagnostic imaging*; D055815:Young Adult