Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression.
The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis. On Opisthorchis viverrini infection treated with dietary curcumin apoptosis-related gene expression profiles were similar to O. viverrini-infected group, but the expression levels seemed lower. Light microscopic observation revealed that aggregation of inflammatory cells surrounding the hepatic bile ducts in the groups infected with O. viverrini and treated with dietary curcumin was lower than in infected group. The intensity of the response is correlated with expression of the genes studied. The results suggest that curcumin reduces pathogenesis in hamster-opisthorchiasis by controlling apoptosis-related gene expression.
Sriraj
Pranee
P
Faculty of Medical Technology, Rangsit University, Pathum Thani.
Boonmars
Thidarut
T
Boonjaraspinyo
Sirintip
S
Kaewsamut
Butsara
B
Srisawangwong
Tuanchai
T
Sithithaworn
Paiboon
P
Wu
Zhiliang
Z
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics*; D006224:Cricetinae; D003474:Curcumin / Q000494:pharmacology*; D015870:Gene Expression; D008297:Male; D009889:Opisthorchiasis / Q000188:drug therapy* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D003474:Curcumin