title: Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.
abstract: Ror1 is a member of the Ror-family receptor tyrosine kinases. Ror1 is broadly expressed in various tissues and organs during mouse embryonic development. However, so far little is known about its function. The closely related family member Ror2 was shown to play a crucial role in skeletogenesis and has been shown to act as a co-receptor for Wnt5a mediating non-canonical Wnt-signaling. Previously, it has been shown that during embryonic development Ror1 acts in part redundantly with Ror2 in the skeletal and cardiovascular systems. In this study, we report that loss of the orphan receptor Ror1 results in a variety of phenotypic defects within the skeletal and urogenital systems and that Ror1 mutant mice display a postnatal growth retardation phenotype.
authors.affiliation: Institute of Molecular Pathology, 1030 Vienna, Austria.
authors.forename: Natalia
authors.initials: N
authors.lastname: Lyashenko
authors.forename: Martina
authors.initials: M
authors.lastname: Weissenböck
authors.forename: Amnon
authors.initials: A
authors.lastname: Sharir
authors.forename: Reinhold G
authors.initials: RG
authors.lastname: Erben
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Minami
authors.forename: Christine
authors.initials: C
authors.lastname: Hartmann
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities*; D005317:Fetal Growth Retardation / Q000209:etiology*; D051379:Mice; D010641:Phenotype; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000172:deficiency* / Q000502:physiology; D014564:Urogenital Abnormalities
chemical_list: D057050:Receptor Tyrosine Kinase-like Orphan Receptors