Atherosclerotic renovascular disease and the heart.
The detrimental link between cardiac and renal pathophysiology in atherosclerotic renovascular disease (ARVD) is well described. Patients with ARVD usually have significant atherosclerotic disease in other vascular beds including the coronary circulation, and structural and functional cardiac changes are highly prevalent. This excess cardiovascular burden probably contributes to the increased cardiac morbidity and mortality seen in these patients. In this review we describe the associations of cardiovascular disease and ARVD and treatment thereof. The clinical debate of which patients are offered any additional advantage by revascularisation over medications alone remains to be answered. The close link between cardiac and renal pathophysiology in ARVD raises the possibility that renal revascularisation might confer a benefit to cardiac morphology and function. This is the subject of ongoing randomised controlled trials.
Chrysochou
Constantina
C
Renal Department, Salford Royal Hospital, Salford, Greater Manchester, M6 8HD, UK. tinachrysochou@yahoo.co.uk
Kalra
Philip A
PA
D017130:Angioplasty; D050197:Atherosclerosis / Q000451:nursing* / Q000503:physiopathology* / Q000628:therapy; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000451:nursing* / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D005919:Glomerular Filtration Rate / Q000502:physiology; D006331:Heart Diseases / Q000451:nursing* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D011379:Prognosis; D012078:Renal Artery Obstruction / Q000451:nursing* / Q000503:physiopathology* / Q000628:therapy; D012307:Risk Factors