title: Old drug--new insights--better treatment?
authors.forename: Christopher
authors.initials: C
authors.lastname: Diakos
authors.forename: Leo
authors.initials: L
authors.lastname: Kager
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D015971:Gene Expression Regulation, Enzymologic; D015973:Gene Expression Regulation, Leukemic; D056284:Histone Deacetylase 1 / Q000235:genetics / Q000378:metabolism; D008727:Methotrexate / Q000493:pharmacokinetics / Q000627:therapeutic use; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism*; D010453:Peptide Synthases / Q000096:biosynthesis* / Q000235:genetics; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D000964:Antimetabolites, Antineoplastic; D051792:Basic Helix-Loop-Helix Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D056284:Histone Deacetylase 1; D008727:Methotrexate; D046912:Multiprotein Complexes; D015514:Oncogene Proteins, Fusion; D010453:Peptide Synthases; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D011518:Proto-Oncogene Proteins; D016160:Retinoblastoma Protein; C493728:RUNX1 protein, human; C407909:TCF3 protein, human; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein; C083400:PBX1 protein, human; C110550:HDAC1 protein, human; C023103:folylpolyglutamate synthetase