title: Cerebral sinus venous thrombosis in Swiss children.
abstract: AIMo describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) in Switzerland.
  
  
  METHODS
  data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow-up examination and a cognitive assessment were performed (mean follow-up period 26mo). Differences between neonates and children (patients older than 28d) were assessed and predictors of outcome were determined.
  
  
  RESULTS
  twenty-one neonates (14 males, seven females; mean age 9d, SD 8d) and 44 children (30 males, 14 females; mean age 8y 7mo, SD 4y 5mo) were reported. The incidence of paediatric CSVT in Switzerland was 0.558 per 100000 per year. In neonates, the deep venous system was more often involved and parenchymal injuries were more common. The strongest predictor of poor outcome was neonatal age (odds ratio 17.8, 95% confidence interval 0.847-372.353). Most children showed global cognitive abilities within the normal range, but impairments in single cognitive subdomains were frequent.
  
  
  CONCLUSIONS
  paediatric CSVT is rare. Its outcome is poor in neonates. Most children have good neurological outcomes, but some patients have individual neuropsychological impairments.
authors.affiliation: Department of Neuropaediatrics, University Children's Hospital, Inselspital, Berne, Switzerland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Grunt
authors.forename: Kevin
authors.initials: K
authors.lastname: Wingeier
authors.forename: Edith
authors.initials: E
authors.lastname: Wehrli
authors.forename: Eugen
authors.initials: E
authors.lastname: Boltshauser
authors.forename: Andrea
authors.initials: A
authors.lastname: Capone
authors.forename: Joel
authors.initials: J
authors.lastname: Fluss
authors.forename: Danielle
authors.initials: D
authors.lastname: Gubser-Mercati
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Jeannet
authors.forename: Elmar
authors.initials: E
authors.lastname: Keller
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marcoz
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitt-Mechelke
authors.forename: Peter
authors.initials: P
authors.lastname: Weber
authors.forename: Markus
authors.initials: M
authors.lastname: Weissert
authors.forename: Maja
authors.initials: M
authors.lastname: Steinlin
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D002658:Developmental Disabilities / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D013557:Switzerland / Q000453:epidemiology