Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.
Nischwitz
Sandra
S
Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Cepok
Sabine
S
Kroner
Antje
A
Wolf
Christiane
C
Knop
Matthias
M
Müller-Sarnowski
Felix
F
Pfister
Hildegard
H
Roeske
Darina
D
Rieckmann
Peter
P
Hemmer
Bernhard
B
Ising
Marcus
M
Uhr
Manfred
M
Bettecken
Thomas
T
Holsboer
Florian
F
Müller-Myhsok
Bertram
B
Weber
Frank
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051567:Proto-Oncogene Proteins c-vav / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D055815:Young Adult; D016335:Zinc Fingers / Q000235:genetics* / Q000276:immunology*
D006680:HLA Antigens; D051567:Proto-Oncogene Proteins c-vav; D012097:Repressor Proteins; C093651:VAV2 protein, human; C552877:ZNF433 protein, human