title: Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.
abstract: Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.
authors.forename: Bing-Dong
authors.initials: BD
authors.lastname: Lin
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Han
authors.forename: Yin-Chun
authors.initials: YC
authors.lastname: Ji
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Chen
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Geng
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C551606:trigoxyphin A; C551607:trigoxyphin B; C551605:trigoxyphin G; C011309:mezerein