title: RETRACTED: Genetic signatures of exceptional longevity in humans.
abstract: Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls. Using these data, we built a genetic model that includes 150 single-nucleotide polymorphisms (SNPs) and found that it could predict EL with 77% accuracy in an independent set of centenarians and controls. Further in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characterized by different combinations of SNP genotypes-or genetic signatures-of varying predictive value. The different signatures, which attest to the genetic complexity of EL, correlated with differences in the prevalence and age of onset of age-associated diseases (e.g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging.
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. sebas@bu.edu
authors.forename: Paola
authors.initials: P
authors.lastname: Sebastiani
authors.forename: Nadia
authors.initials: N
authors.lastname: Solovieff
authors.forename: Annibale
authors.initials: A
authors.lastname: Puca
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Hartley
authors.forename: Efthymia
authors.initials: E
authors.lastname: Melista
authors.forename: Stacy
authors.initials: S
authors.lastname: Andersen
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Dworkis
authors.forename: Jemma B
authors.initials: JB
authors.lastname: Wilk
authors.forename: Richard H
authors.initials: RH
authors.lastname: Myers
authors.forename: Martin H
authors.initials: MH
authors.lastname: Steinberg
authors.forename: Monty
authors.initials: M
authors.lastname: Montano
authors.forename: Clinton T
authors.initials: CT
authors.lastname: Baldwin
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Perls