Asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide to aldehydes.
The asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide with aldehydes has been developed, giving the corresponding 5-(1'-hydroxy)butenolide derivatives in high yields (up to 93%) and enantioselectivities (up to 83% ee) under mild conditions.
Yang
Yang
Y
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Zheng
Ke
K
Zhao
Jiannan
J
Shi
Jian
J
Lin
Lili
L
Liu
Xiaohua
X
Feng
Xiaoming
X
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000447:Aldehydes; C116609:3-hydroxybutanal; C004511:butenolide; D015107:4-Butyrolactone