Lack of association between PRNP M129V polymorphism and multiple sclerosis, mild cognitive impairment, alcoholism and schizophrenia in a Korean population.
The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion diseases. In this study, we examined the possible genetic association of PRNP*129Val with multiple sclerosis (MS, n=681), mild cognitive impairment (MCI, n=801), alcoholism (n=761) and schizophrenia (n=715) in a Korean population, and compared the data with previous genetic association studies of the variant. The minor allele frequency of PRNP*129Val (MAF =0.025) was significantly lower in Korean population (n=2,479) compared to Caucasian populations (P < 0.0001), suggestive of a weak influence of the variant in the previous population. Statistical analysis revealed no significant association between PRNP*129Val and MS (P= 0.76), MCI (P=0.46), alcoholism (P=0.84) and schizophrenia (P =0.69). These findings were discussed in the context of prior inconsistent reports on the role of PRNP*129Val polymorphism in several diseases. Results from this study may provide further evidence that PRNP M129V is not a genetic susceptibility factor for MS, MCI, alcoholism and schizophrenia in a Korean population.
Choi
Ihn-Geun
IG
Department of Neuropsychiatry, Hallym University, Han-Gang Sacred Heart Hospital, Seoul, Korea.
Woo
Sung-Il
SI
Kim
Ho Jin
HJ
Kim
Dai-Jin
DJ
Park
Byung Lae
BL
Cheong
Hyun Sub
HS
Pasaje
Charisse Flerida A
CF
Park
Tae Joon
TJ
Bae
Joon Seol
JS
Chai
Young Gyu
YG
Shin
Hyoung Doo
HD
D000368:Aged; D000437:Alcoholism / Q000235:genetics*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions