HLA-G*0105N allele is associated with augmented risk for HIV infection in white female patients.
We analyzed HLA-G 3777G > C, HLA-G 14 bp deletion/insertion and HLA-G*0105N polymorphisms in HIV-positive white adult participants, infected through horizontal heterosexual transmission, and unexposed uninfected individuals, all from north eastern Italy. We report a new association between the HLA-G*0105N allele and HIV infection in adult white female participants, being HLA-G*0105N null allele correlated with an augmented risk (odds ratio = 4.35, 95% confidence interval = 1.38-18.07, P = 0.005) for HIV infection.
Segat
Ludovica
L
Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. segat@burlo.trieste.it
Catamo
Eulalia
E
Fabris
Annalisa
A
Morgutti
Marcello
M
D'Agaro
Pierlanfranco
P
Campello
Cesare
C
Crovella
Sergio
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015658:HIV Infections / Q000235:genetics* / Q000635:transmission; D015497:HIV-1 / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
D015395:Histocompatibility Antigens Class I