Luteolin suppresses growth and migration of human lung cancer cells.
Luteolin, 3',4',5,7-tetrahydroxyflavone, has been shown to possess antioxidant, anti-inflammation and anti-cancer properties. However, its role in lung cancer remains poorly understood. Here we examined the anti-tumorigenic role of luteolin in a commonly used lung cancer cell line. Luteolin inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fiber assembly and cell migration in A549 cells was markedly suppressed by luteolin.
Zhao
Yunxue
Y
Department of Pharmacology, School of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, People's Republic of China.
Yang
Guotao
G
Ren
Dongmei
D
Zhang
Xiumei
X
Yin
Qiuwei
Q
Sun
Xuefei
X
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002465:Cell Movement; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism*; D047311:Luteolin / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D051379:Mice; D051336:Mitochondrial Membranes / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D047311:Luteolin