Long antisense non-coding RNAs and their role in transcription and oncogenesis.
Long non-coding RNAs are estimated to qualitatively represent ~98% of expressed transcripts in human cells, a large proportion of which is antisense to protein-coding and non-coding transcripts. Here we review evidence from several experimental systems that suggests long antisense non-coding RNAs are involved in the transcriptional regulation of gene expression by altering epigenetic states at both adjacent and distal loci. We also review the initial evidence for a role of endogenous long antisense non-coding RNAs in oncogenic cellular transformation.
Morris
Kevin V
KV
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA. kmorris@scipps.edu
Vogt
Peter K
PK
D006801:Humans; D008957:Models, Genetic; D011230:Precancerous Conditions / Q000235:genetics*; D016372:RNA, Antisense / Q000378:metabolism*; D022661:RNA, Untranslated / Q000378:metabolism*; D014158:Transcription, Genetic
D016372:RNA, Antisense; D022661:RNA, Untranslated