title: Studies on a novel multi-sensitive hydrogel: influence of the biomimetic phosphorylcholine end-groups on the PEO-PPO-PEO tri-block co-polymers.
abstract: In the present study, a biomimetic phosphorylcholine group was employed in the end-capping modification of PEO-PPO-PEO tri-block co-polymers (Pluronic(®)). The structures of the resulting materials were characterized by (1)H-NMR and GPC. The effects of the additional phosphorylcholine end-groups to the thermo-sensitive sol-gel transition behaviors of the aqueous solutions of the resulting polymers were studied by rheology test in neutral (0.1 M NaCl) aqueous solutions and in acidic solutions (pH 3). It was found that the phosphorylcholine-end-capped Pluronic hydrogels still kept their thermo-sensitive mechanical properties with a slight change on the sol-gel transition behaviors. The phosphorylcholine-modified Pluronics exhibited a response to the change of the pH value, which made this kind of material a multi-sensitive hydrogel system. Also, the resulting polymers showed improved hemocompatibilities in the blood coagulation test using full human blood.
authors.affiliation: The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, PR China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Meng
authors.forename: Zhang
authors.initials: Z
authors.lastname: Guo
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: ZongJun
authors.initials: Z
authors.lastname: Liu
authors.forename: QiHong
authors.initials: Q
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.forename: QiangGuo
authors.initials: Q
authors.lastname: Du
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D032701:Biomimetics; D001780:Blood Coagulation Tests; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D015394:Molecular Structure; D044367:Phase Transition; D010767:Phosphorylcholine / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; C116176:PEO-PPO-PEO; D011108:Polymers; D011409:Propylene Glycols; D010767:Phosphorylcholine; D011092:Polyethylene Glycols