BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu2+ in living cells.
A new fluoro-chromogenic chemosensor based on BODIPY-functionalized gold nanoparticles 1 is prepared. Addition of Cu(2+) ions to aqueous solutions of 1 gave an instantaneous color change along with a blue-shift of the absorption band and quenching of the emission spectrum at room temperature. The chemosensor 1 exhibits a high affinity and selectivity for Cu(2+) over competing metal ions tested. Moreover, confocal microscopy experiments establish that 1 can be used for detecting Cu(2+) levels within living cells.
Lee
Hye Young
HY
Department of Chemistry and Research Institute of Natural Science, Gyeongsang National University, Jinju 660-701, S. Korea.
Son
Hyunjong
H
Lim
Jung Mi
JM
Oh
Jungmin
J
Kang
Dongmin
D
Han
Won Seok
WS
Jung
Jong Hwa
JH
D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D003300:Copper / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence
D006046:Gold; D003300:Copper