[Postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery].
OBJECTIVE
To investigate the postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery.


METHODS
Eighty patients undergoing posterior spinal surgery under general anesthesia were randomly divided into parecoxib sodium group and placebo group (n=40). All the patients received a single dose of m ml morphine (1.0 mg/ml) as the background analgesia immediately after the operation. The patients in parecoxib sodium group were given 40 mg parecoxib sodium intravenously, and those in the placebo group received an equivalent volume of saline instead, and at 24 and 48 h after the operation, the same dose was repeated. The visual analog pain score, patient satisfaction and adverse reactions were recorded after the administrations.


RESULTS
Compared with the placebo group, the patients in parecoxib sodium group had significantly lowered VAS score at 6, 12, 24, and 48 h after the operation (P<0.05). No significant differences were noted in the patient satisfaction and adverse reactions between the two groups.


CONCLUSIONS
Postoperative short-term use of parecoxib sodium can can provide good postoperative analgesic effect in patients undergoing posterior spinal surgery.
Cai
Ming-xue
MX
Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. caimingxue6666@126.com
Li
Ya-lan
YL
Lin
Hong-sheng
HS
Peng
Xue-mei
XM
Wu
Hao
H
D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000768:Anesthesia, General; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D013122:Spinal Diseases / Q000601:surgery*
D018712:Analgesics, Non-Narcotic; D052246:Cyclooxygenase 2 Inhibitors; D007555:Isoxazoles; C409945:parecoxib