Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.
Dendritic cells (DCs) are of pivotal importance for the initiation of immune responses to control and eliminate viral infections. The molecular mechanisms of hepatitis C virus (HCV) antigen uptake and processing by blood DCs are poorly defined. Here we show that human blood DC subsets acquire HCV independent of the classical HCV entry factors. Following HCV uptake, human plasmacytoid and myeloid DC subsets deliver HCV antigen into distinct endocytotic compartments, which are dedicated to presentation to CD4(+) or CD8(+) T cells. Our findings support a model of HCV antigen processing and presentation in which DC subsets fulfill distinct functions.
Lambotin
Mélanie
M
INSERM U748, Université de Strasbourg, 67000 Strasbourg, France.
Baumert
Thomas F
TF
Barth
Heidi
H
D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D016174:Hepacivirus / Q000276:immunology* / Q000502:physiology; D006526:Hepatitis C / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D018936:Hepatitis C Antigens / Q000276:immunology / Q000378:metabolism; D006801:Humans; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D021381:Protein Transport
D018936:Hepatitis C Antigens