title: Scleroderma-like cutaneous lesions induced by paclitaxel and carboplatin for ovarian carcinoma, not a single course of carboplatin, but re-induced and worsened by previously administrated paclitaxel.
abstract: Scleroderma-like cutaneous lesion as an adverse event from paclitaxel and carboplatin has been reported. No report shows the occurrence of scleroderma-like cutaneous lesions from a single course of carboplatin. The patient is a 67-year-old female, administered paclitaxel and carboplatin as neoadjuvant chemotherapy. Following four courses, scleroderma-like cutaneous lesions were demonstrated. Skin biopsy corresponded to histopathological findings of scleroderma. Immunological investigation shows only antinuclear antibodies are positive. The characteristic Raynaud's phenomenon of scleroderma and hemorrhagic spots on the cuticles were not found. Postoperatively, a single course of carboplatin treatment was given. Scleroderma-like cutaneous lesions re-induced and worsened. This is the first report detailing scleroderma-like cutaneous lesions induced by previously administrated paclitaxel that worsened by carboplatin.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Akita University School of Medicine, Akita, Japan. konishi@momo.so-net.ne.jp
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Konishi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Sato
authors.forename: Naoki
authors.initials: N
authors.lastname: Sato
authors.forename: Toshio
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Jun
authors.initials: J
authors.lastname: Fukuda
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D016190:Carboplatin / Q000009:adverse effects* / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000139:chemically induced*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel