Tigecycline treatment of multi-drug-resistant Corynebacterium jeikeium infection in a child with relapsing and refractory acute lymphoblastic leukemia.
Corynebacterium jeikeium has been recognized as an important cause of infection, particularly among neutropenic patients who have central venous catheter (CVC). Routine use of tigecycline in children is not yet approved. Here in we present a child with relapsed-refractory lymphoblastic leukemia who was successfully treated with tigecyline due to multi-drug-resistant C. jeikeium sepsis without removal of CVC. Our case highlights the use of tigecycline where there are no alternatives. Further studies regarding the efficacy and safety of tigecycline in pediatric patients are needed.
Dinleyici
Ener Cagri
EC
Faculty of Medicine, Department of Pediatrics, Eskisehir Osmangazi University, Eskisehir, Turkey. timboothtr@yahoo.com
Yargic
Zeynel Abidin
ZA
Bor
Ozcan
O
Kiremitci
Abdurrahman
A
Durmaz
Gul
G
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D055499:Catheter-Related Infections; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D003354:Corynebacterium Infections / Q000188:drug therapy*; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology; D012008:Recurrence; D012074:Remission Induction; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline