title: Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists.
authors.affiliation: Neurosciences Center of Excellence for Drug Discovery, GlaxoSmithKline Medicines Research Center, Via A. Fleming 4, 37135 Verona, Italy. fabio.m.sabbatini@GSK.com
authors.forename: Fabio Maria
authors.initials: FM
authors.lastname: Sabbatini
authors.forename: Romano
authors.initials: R
authors.lastname: Di Fabio
authors.forename: Mauro
authors.initials: M
authors.lastname: Corsi
authors.forename: Paolo
authors.initials: P
authors.lastname: Cavanni
authors.forename: Steve M
authors.initials: SM
authors.lastname: Bromidge
authors.forename: Yves
authors.initials: Y
authors.lastname: St-Denis
authors.forename: Lucilla
authors.initials: L
authors.lastname: D'Adamo
authors.forename: Stefania
authors.initials: S
authors.lastname: Contini
authors.forename: Marilisa
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Sebastien
authors.initials: S
authors.lastname: Guery
authors.forename: Chiara
authors.initials: C
authors.lastname: Savoia
authors.forename: Claudia
authors.initials: C
authors.lastname: Mundi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Perini
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Carpenter
authors.forename: Giovanna
authors.initials: G
authors.lastname: Dal Forno
authors.forename: Federico
authors.initials: F
authors.lastname: Faggioni
authors.forename: Michela
authors.initials: M
authors.lastname: Tessari
authors.forename: Francesca
authors.initials: F
authors.lastname: Pavone
authors.forename: Carla
authors.initials: C
authors.lastname: Di Francesco
authors.forename: Alberto
authors.initials: A
authors.lastname: Buson
authors.forename: Mario
authors.initials: M
authors.lastname: Mattioli
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Perdona'
authors.forename: Sergio
authors.initials: S
authors.lastname: Melotto
mesh_terms: D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D001068:Feeding and Eating Disorders / Q000188:drug therapy; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D054440:Receptors, Ghrelin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D006834:Hydrazines; D054440:Receptors, Ghrelin; C019289:carbohydrazide