title: [Molecular epidemiological characteristics of norovirus gastroenteritis outbreaks in Guangdong from 2005 to 2008].
abstract: To study the molecular epidemiological characteristics of norovirus gastroenteritis outbreaks in Guangdong, we collected fecal and anal swabs specimens from 24 outbreaks of acute gastroenteritis from 2005 to 2008 to detect norovirus. Specimens were detected by RT-PCR and then sequenced. The descriptive data were also collected. According to our research, 19 of 24 outbreaks of gastroenteritis were positive for norovirus. The occurrence time was from October to next February mainly. The strains in 2005 belonged to G II-3 genotype and all outbreaks occurred in kindergarten and school. But from autumn of 2006, the outbreaks were all caused by G II-4/2006b variant and occurred in universities and community. The number of outbreaks in 2007 increased greatly and covered all over province. The nucleotide sequences of Guangdong strains in some sites showed high regional identity. Our results showed that with the shift of genotype from G II-3 to G II-4, occurrence of norovirus outbreaks increased greatly. The outbreaks of norovirus caused by G II-4/2006b variant spreaded widely and the involved population covered children and adult, indicating the strong invasiveness of this variant.
authors.affiliation: Centers for Disease Control and Prevention of Guangdong Province, Guangzhou 510300, China. gzli_hui@tom.com
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Mo
authors.forename: Chang-wen
authors.initials: CW
authors.lastname: Ke
authors.forename: Hui-zhen
authors.initials: HZ
authors.lastname: Zheng
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Zhou
authors.forename: Ru-ning
authors.initials: RN
authors.lastname: Guo
authors.forename: Qiu-xia
authors.initials: QX
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Zou
mesh_terms: D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002648:Child; D002681:China / Q000453:epidemiology; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004196:Disease Outbreaks; D005759:Gastroenteritis / Q000453:epidemiology*; D006801:Humans; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification / Q000201:enzymology / Q000235:genetics*; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D012321:DNA-Directed RNA Polymerases