title: Focal retrograde amnesia: Extending the clinical syndrome of transient epileptic amnesia.
abstract: A 44-year-old woman presented with focal retrograde amnesia and complaints of rapid forgetting in the absence of episodes of transient cognitive disturbance. Her MRI and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) were normal. On standard neuropsychological tests she performed within the normal range although a test of autobiographical memory confirmed impoverished recall especially involving recent life events. The electroencephalograph (EEG) recordings were suggestive of temporal lobe epilepsy but no clear diagnosis was established. After 4 years the patient's recurrent brief episodes of disorientation, suggestive of transient epileptic amnesia (TEA), were corroborated by her sister. This diagnosis was confirmed by an ambulatory EEG that revealed ictal activity. Several important points emerge from this study. Focal retrograde amnesia can be a prodromal symptom of TEA which can precede the full-blown syndrome by several years. Moreover, transient attacks might not be reported if patients live alone. The ictal EEG findings further substantiate the epileptic nature of the syndrome.
authors.affiliation: Prince of Wales Medical Research Institute, Corner of Barker Street and Easy Street, Randwick, New South Wales 2031, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Hornberger
authors.forename: Armin
authors.initials: A
authors.lastname: Mohamed
authors.forename: Laurie
authors.initials: L
authors.lastname: Miller
authors.forename: John
authors.initials: J
authors.lastname: Watson
authors.forename: Zoe
authors.initials: Z
authors.lastname: Thayer
authors.forename: John R
authors.initials: JR
authors.lastname: Hodges
mesh_terms: D000328:Adult; D000648:Amnesia, Retrograde / Q000209:etiology*; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000150:complications*; D005260:Female; D006801:Humans; D011939:Mental Recall / Q000502:physiology; D009483:Neuropsychological Tests