New cytotoxic oxygenated sterols from marine bryozoan Bugula neritina.
Two new oxygenated sterols, 3β,24(S)-dihydroxycholesta-5,25-dien-7-one and 3β,25-dihydroxycholesta-5,23-dien-7-one, were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC₅₀ values between 22.58 and 53.41 µg mL⁻¹.
Yang
Fan
F
Department of Pharmacy, Laboratory of Marine Drugs, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Zhang
Hong-Jun
HJ
Chen
Jian-Tao
JT
Tang
Hai-Feng
HF
Piao
Shu-Juan
SJ
Chen
Wan-Sheng
WS
Lin
Hou-Wen
HW
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002013:Bryozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002783:Cholestenones; D054697:Cytostatic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C570264:3beta,24(S)-dihydroxycholesta-5,25-dien-7-one; C570265:3beta,25-dihydroxycholesta-5,23-dien-7-one; D000970:Antineoplastic Agents; D002783:Cholestenones; D054697:Cytostatic Agents; D013261:Sterols