Efficacy of a tin/fluoride rinse: a randomized in situ trial on erosion.
Concentrated tin- and fluoride-containing mouthrinses are effective erosion inhibitors in enamel and dentin. To test whether this is also true for solutions with lower concentrations, we conducted a randomized double-blind three-cell crossover in situ study with extra-orally performed erosive impacts (citric acid, 6 x 5 min/day) and an intra-oral rinsing protocol (1 x 30 sec/day) in 24 volunteers. The mouthrinses were a placebo, a NaF (500 ppm F⁻), and an amine fluoride (AmF)/NaF/SnCl₂ mouthrinse (500 ppm F⁻, 800 ppm Sn(2+)). Compared with the placebo, the NaF mouthrinse reduced substance loss by 19% in enamel and 23% in dentin (p ≤ 0.01 each); the AmF/NaF/SnCl₂ mouthrinse reduced this parameter by 67% in enamel and 47% in dentin (p ≤ 0.001 each). AmF/NaF/SnCl₂ was significantly more effective than NaF in both tissues (p ≤ 0.01). The mouthrinse containing Sn and F exhibited good efficacy, even under severe erosive conditions.
Ganss
C
C
Department of Conservative and Preventive Dentistry, Dental Clinic of the Justus Liebig University, Schlangenzahl 14, D-35392 Giessen, Germany. carolina.ganss@dentist.med.uni-giessen.de
Neutard
L
L
von Hinckeldey
J
J
Klimek
J
J
Schlueter
N
N
D000328:Adult; D000588:Amines / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use*; D019343:Citric Acid / Q000009:adverse effects; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D010919:Placebos; D011446:Prospective Studies; D012969:Sodium Fluoride / Q000627:therapeutic use*; D017971:Tin Compounds / Q000627:therapeutic use*; D017001:Tooth Demineralization / Q000517:prevention & control; D014077:Tooth Erosion / Q000517:prevention & control*; D016896:Treatment Outcome
D000588:Amines; D002327:Cariostatic Agents; D009067:Mouthwashes; D010919:Placebos; D017971:Tin Compounds; C023599:stannous chloride; D019343:Citric Acid; D012969:Sodium Fluoride