title: Investigation of interleukin-13 gene polymorphisms in individuals with chronic and generalized aggressive periodontitis in a Taiwanese (Chinese) population.
abstract: OBJECTIVE
  The interleukin-13 (IL-13) -1112 C/T polymorphisms have been analyzed previously in a North European population of patients with aggressive periodontitis. The present study was carried out to investigate the association of polymorphisms in the IL-13 gene with susceptibility to periodontitis in a Taiwanese population.
  
  
  METHODS
  The genotyping of IL-13 -1112 C/T polymorphisms in 60 patients with aggressive periodontitis, 204 patients with chronic periodontitis and 95 healthy controls was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Genotypes and allele frequencies among study groups were compared using Fisher's exact test (p < 0.05). Pearson's chi-square test was used for analysis of the Hardy-Weinberg equilibrium.
  
  
  RESULTS
  The distributions of CC genotypes and C alleles between patients with aggressive periodontitis and healthy controls were significantly different (p = 0.034 and 0.046). After adjustment for age, gender, betel nut chewing and smoking status using logistic regression analysis, the odds ratio (OR) was 6.45 [95% confidence interval (CI) = 1.99-23.72, p = 0.003] for aggressive periodontitis. However, the CC genotype was only significantly associated with the risk of aggressive periodontitis in the nonsmoking group (OR = 4.48, 95% CI = 1.31-16.93, p = 0.020).
  
  
  CONCLUSIONS
  The CC genotype or C allele appears to increase the risk of developing aggressive periodontitis in Taiwanese subjects.
authors.affiliation: Division of Periodontics, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Y-M
authors.initials: YM
authors.lastname: Wu
authors.forename: H-L
authors.initials: HL
authors.lastname: Chuang
authors.forename: Y-P
authors.initials: YP
authors.lastname: Ho
authors.forename: K-Y
authors.initials: KY
authors.lastname: Ho
authors.forename: C-C
authors.initials: CC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000208:ethnology; D055113:Chronic Periodontitis / Q000235:genetics*; D003596:Cytosine; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan; D013941:Thymine
chemical_list: D018793:Interleukin-13; D003596:Cytosine; D013941:Thymine