title: What infusion flow should be used for mid-dilution hemodiafiltration?
abstract: BACKGROUND
  There is still no consensus on the optimal infusion flow (Qi) in mid-dilution hemodiafiltration. The aim of this study was to compare mid-dilution with varying Qi.
  
  
  METHODS
  Prospective study in 25 patients who underwent seven hemodialysis sessions with a Qi of 0, 50, 100, 150, 200, 250 and 300 ml/min.
  
  
  RESULTS
  All sessions were well tolerated except Qi 300 ml/min. No significant differences in urea, creatinine, alpha(1)-microglobulin or alpha(1)-acid glycoprotein reduction ratios were observed. beta(2)-Microglobulin, myoglobin and prolactin reduction ratios were higher with Qi 150, 200, 250 and 300 ml/min in comparison with Qi of 0, 50 and 100 ml/min. There were no differences in the removal of small or larger molecules when Qi was 150 ml/min or higher.
  
  
  CONCLUSIONS
  Optimal Qi in mid-dilution appears to be in the range of 150-250 ml/min since good clinical outcomes, similar efficiency and no technical complications up to a Qi of 250 ml/min were observed.
authors.affiliation: Department of Nephrology, Hospital Clínic Barcelona, Barcelona, Spain. fmaduell@clinic.ub.es
authors.forename: Francisco
authors.initials: F
authors.lastname: Maduell
authors.forename: Marta
authors.initials: M
authors.lastname: Arias
authors.forename: Néstor
authors.initials: N
authors.lastname: Fontseré
authors.forename: Manel
authors.initials: M
authors.lastname: Vera
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Masso
authors.forename: Julia
authors.initials: J
authors.lastname: Garro
authors.forename: Xoana
authors.initials: X
authors.lastname: Barros
authors.forename: Maria N
authors.initials: MN
authors.lastname: Martina
authors.forename: Montserrat
authors.initials: M
authors.lastname: Elena
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bergadá
authors.forename: Aleix
authors.initials: A
authors.lastname: Cases
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Bedini
authors.forename: Josep M
authors.initials: JM
authors.lastname: Campistol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017583:Hemodiafiltration / Q000009:adverse effects / Q000379:methods*; D006438:Hemodilution / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014511:Uremia / Q000097:blood / Q000628:therapy*; D055815:Young Adult