title: Caudwell xtreme Everest expedition.
abstract: The Caudwell Xtreme Everest (CXE) expedition involved the detailed study of 222 subjects ascending to 5300 m or higher during the first half of 2007. Following baseline measurements at sea level, 198 trekker-subjects trekked to Everest Base Camp (EBC) following an identical ascent profile. An additional group of 24 investigator-subjects followed a similar ascent to EBC and remained there for the duration of the expedition, with a subgroup of 14 collecting data higher on Everest. This article focuses on published data obtained by the investigator-subjects at extreme altitude (>5500 m). Unique measurements of peak oxygen consumption, middle cerebral artery diameter and blood velocity, and microcirculatory blood flow were made on the South Col (7950 m). Unique arterial blood gas values were obtained from 4 subjects at 8400 m during descent from the summit of Everest. Arterial blood gas and microcirculatory blood flow data are discussed in detail.
authors.affiliation: mike.grocott@ucl.ac.uk <mike.grocott@ucl.ac.uk>
authors.forename: Michael P W
authors.initials: MP
authors.lastname: Grocott
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Martin
authors.forename: Mark H
authors.initials: MH
authors.lastname: Wilson
authors.forename: Kay
authors.initials: K
authors.lastname: Mitchell
authors.forename: Sundeep
authors.initials: S
authors.lastname: Dhillon
authors.forename: Monty G
authors.initials: MG
authors.lastname: Mythen
authors.forename: Hugh E
authors.initials: HE
authors.lastname: Montgomery
authors.forename: Denny Z H
authors.initials: DZ
authors.lastname: Levett
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005101:Expeditions; D006801:Humans; D008297:Male; D008875:Middle Aged; D009051:Mountaineering / Q000502:physiology*; D009390:Nepal; D033281:Nontherapeutic Human Experimentation; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012016:Reference Values; D015656:Respiratory Mechanics / Q000502:physiology
chemical_list: D010100:Oxygen