[Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes].
To study the association with diabetes mellitus type 1 we performed analysis of the distribution of frequencies of alleles and genotypes of polymorphic marker rs2292239 of ERBB3 gene, encoding epidermal growth factor receptor type 3 and polymorphic marker rs3184504 of SH2B3 gene, encoding adaptor protein LNK. The study included groups of T1DM patients and unrelated controls of Russian origin. Genotyping was performed using methods of RFLP and real-time amplification. For the polymorphic marker rs2292239 of ERBB3 gene was not found statistically significant associations with type 1 diabetes, while analysis of the distribution of frequencies of alleles and genotypes of the polymorphic marker rs3184504 of SH2B3 gene showed the presence of association with T1DM in Russian population.
Nikitin
A G
AG
Lavrikova
E Iu
EIu
Seregin
Iu A
IuA
Zil'berman
L I
LI
Tsitlidze
N M
NM
Kuraeva
T L
TL
Peterkova
V A
VA
Dedov
I I
II
Nosikov
V V
VV
D048868:Adaptor Proteins, Signal Transducing; D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics*; D020893:Receptor, ErbB-3 / Q000235:genetics*; D012426:Russia / Q000208:ethnology
D048868:Adaptor Proteins, Signal Transducing; D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C490778:SH2B3 protein, human; D020893:Receptor, ErbB-3