title: Varicella susceptibility and transmission dynamics in Slovenia.
abstract: BACKGROUND
  A cross-sectional, age-stratified study was conducted to determine varicella-zoster seroprevalence and force of infection in Slovenia.
  
  
  METHODS
  3689 serum samples were tested for VZV IgG antibodies with an enzyme immunoassay. Semiparametric and parametric modelling were used to estimate the force of infection.
  
  
  RESULTS
  Overall, 85.6% of serum samples were seropositive. Age-specific prevalence rose rapidly in preschool children and over 90% of 8 years old tested positive for VZV. However, 2.8% of serum samples among women of childbearing age were seronegative. Semiparametric modelling yielded force of infection estimates of 0.182 (95% CI 0.158-0.206), 0.367 (95% CI 0.285-0.448) and 0.008 (95% CI 0.0-0.032) for age groups 0.5- < 6, 6-11 and >or=12 years, respectively, and 0.175 (95% CI 0.147-0.202), 0.391 (95% CI 0.303-0.480) and 0.025 (95% CI 0.003-0.046) for age groups 0.5- < 5, 5-9 and >or=10 years, respectively.
  
  
  CONCLUSIONS
  Regardless of the age grouping used, the highest transmission occurred in children in their first years of school.
authors.affiliation: Centre for Communicable Diseases, National Institute of Public Health of Republic of Slovenia, 1000 Ljubljana, Slovenia. maja.socan@ivz-rs.si
authors.forename: Maja
authors.initials: M
authors.lastname: Socan
authors.forename: Natasa
authors.initials: N
authors.lastname: Berginc
authors.forename: Jaro
authors.initials: J
authors.lastname: Lajovic
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002644:Chickenpox / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D019433:Chickenpox Vaccine; D002648:Child; D002675:Child, Preschool; D005260:Female; D014645:Herpesvirus 3, Human; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015233:Models, Statistical; D016036:Seroepidemiologic Studies; D017524:Slovenia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019433:Chickenpox Vaccine