Evaluation of the burn healing properties of oil extraction from housefly larva in mice.
OBJECTIVE
To evaluate the burn wound-healing properties of oil extraction from housefly larva by employing a deep second-degree model in mice.


METHODS
The burn wound-healing properties were evaluated by employing a deep second-degree model of burn wound assay. The anti-inflammatory activity and antibacterial activity were examined by employing the xylene-induced ear swelling model in mice and a disc-diffusion assay, respectively.


RESULTS
The best wound-healing activity was observed with the oil extract of housefly larva, followed by Ching Wan Hung and the least active was that of saline solution. The oil extraction from housefly larva suppressed xylene-induced ear swelling in mice with 35.3% of the inhibition rate at the dose of 0.1 ml/30 g. The disc-diffusion assay of housefly larva oil showed positive effect to Pseudomonas aeruginosa and Staphylococcus aureus, exhibiting no antibacterial activity to Escherichia coli.


CONCLUSIONS
The study provides useful information that the housefly larva oil could be used as a natural ointment to heal the burn wound.
Feng
Xi
X
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Cheng
Gang
G
Chen
Shu-yuan
SY
Yang
Hong
H
Huang
Wen
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006793:Houseflies; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D007814:Larva; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D009821:Oils / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D009821:Oils