title: No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population.
abstract: Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP. We found no significant differences between the two groups with regard to both genotype distributions (chi(2) = 1.32, d.f. = 2, P = 0.516) and allele frequencies (chi(2) = 0.01, d.f. = 1, P = 0.913, odds ratio = 0.96, 95% confidence interval = 0.67-1.39). Therefore, this single nucleotide polymorphism appears not to be involved in the etiology of MDD.
authors.affiliation: Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. tewin.t@chula.ac.th
authors.forename: T
authors.initials: T
authors.lastname: Tencomnao
authors.forename: V
authors.initials: V
authors.lastname: Thongrakard
authors.forename: W
authors.initials: W
authors.lastname: Phuchana
authors.forename: T
authors.initials: T
authors.lastname: Sritharathikhun
authors.forename: S
authors.initials: S
authors.lastname: Suttirat
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013785:Thailand
chemical_list: D044402:Receptor, Serotonin, 5-HT2A