title: Monoliths with chiral surface functionalization for enantioselective capillary electrochromatography.
abstract: The state-of-the-art in CEC enantiomer separations with monolithic capillary columns is comprehensively reviewed. The various types of monolithic columns comprising in situ organic polymer monoliths, molecularly imprinted polymer (MIP) monoliths, silica monoliths and monoliths made from particles are discussed with a focus on materials' synthesis, chemistry and properties as well as column aspects. Monolithic MIP-type porous layer open-tubular (PLOT) columns are treated herein as well. From this survey of the literature, the authors come to the conclusion that monolithic silica capillaries appear to become the preferred column type for CEC enantiomer separations of low-molecular drugs and other chiral pharmaceuticals or chemicals.
authors.affiliation: Department of Analytical Chemistry, University of Vienna, Waehringer Strasse 38, 1090 Vienna, Austria. michael.laemmerhofer@univie.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Lämmerhofer
authors.forename: Andrea
authors.initials: A
authors.lastname: Gargano
mesh_terms: D000818:Animals; D053801:Capillary Electrochromatography / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D013237:Stereoisomerism; D013499:Surface Properties
chemical_list: D004364:Pharmaceutical Preparations