[The effect of 2,4-dinitrophenol on the intensity of oxidative processes in the rat liver during prolonged experiment].
The effect of uncoupler 2,4-dinitrophenol on the oxidative processes intensity in liver biomembranes of different age and sex of rats during longitudinal experiment was studied. It was established that 2,4-dinitrophenol in the used concentration hadn't essential negative effect on the organism of females and their posterity. On the young, 3-3,5-month old males it was shown that long-term xenobiotic administration had been accompanied by intensification of the rate of oxygen consumption, decrease of the rate of reactive oxygen species formation in microsomal redox-chain, decline in lipid hydroperoxides and protein carbonils levels in blood serum and liver microsomes, and also by increase of their mean lifespan. The obtained results may testify the possibility of correction of oxidative processes intensity in tissues of mammals and their lifespan by means of modulation of membrane electron transport chains activity.
Padalko
V I
VI
Leonova
I S
IS
Kozlova
E V
EV
D019297:2,4-Dinitrophenol / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D018811:Maternal Exposure; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014475:Uncoupling Agents / Q000494:pharmacology*
D014475:Uncoupling Agents; D019297:2,4-Dinitrophenol