Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.
Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.
Drobeniuc
Jan
J
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA. jqd6@cdc.gov
Meng
Jihong
J
Reuter
Gábor
G
Greene-Montfort
Tracy
T
Khudyakova
Natasha
N
Dimitrova
Zoya
Z
Kamili
Saleem
S
Teo
Chong-Gee
CG
D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000175:diagnosis*; D016752:Hepatitis E virus / Q000145:classification* / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014773:Virology / Q000379:methods*
D006508:Hepatitis Antibodies; D007075:Immunoglobulin M