Zygomycotic invasion of the central nervous system.
Zygomycosis is an opportunistic fungal infection that affects the central nervous system (CNS). In this report, we present three cases of zygomycosis with CNS involvement. In two patients zygomycosis developed after neurosurgery, and in the third patient zygomycosis developed after bone marrow transplantation for leukemia. All patients developed persistent fever and neurological deficits. They presented with progressive cerebral infarction accompanied by hemorrhage. Intraoperative findings and histopathological examinations revealed that zygomycotic hyphae caused mycotic aneurysm, vasculitis, and venous occlusion.
Sasaki
Tomoaki
T
Department of Radiology, Asahikawa Red Cross Hospital, Akebono, Asahikawa, Japan. tomoaki3est@gmail.com
Mineta
Masayuki
M
Kobayashi
Keigo
K
Ando
Masakatsu
M
Obata
Masahiko
M
D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D002544:Cerebral Infarction / Q000209:etiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D019635:Neurosurgical Procedures; D009894:Opportunistic Infections; D011183:Postoperative Complications; D011859:Radiography; D020096:Zygomycosis / Q000000981:diagnostic imaging / Q000209:etiology*