title: Pharmacological activities on Ephedra nebrodensis Tineo.
abstract: As a part of our endeavour to screen Mediterranean medicinal plants for various pharmacological activities, we evaluated antihistaminic, adaptogenic, anti-inflammatory, antinociceptive, hypotensive and locomotor properties, and antioxidant potential of Ephedra nebrodensis. (1)H-NMR spectroscopy was carried out to identify the plant metabolites, which confirmed the presence of ephedrinic skeleton alkaloids. The ethanol : acetone (1 : 1) extract exhibited dose-related antihistaminic, anti-inflammatory, antinociceptive, hypotensive, antioxidant and locomotor stimulant activity. The plant bears potential for further studies.
authors.affiliation: CoSMeSe, Department of Botanical Sciences, University of Cagliari, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Ballero
authors.forename: Caterina
authors.initials: C
authors.lastname: Foddis
authors.forename: Cinzia
authors.initials: C
authors.lastname: Sanna
authors.forename: Paolo
authors.initials: P
authors.lastname: Scartezzini
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Poli
authors.forename: Valentina
authors.initials: V
authors.lastname: Petitto
authors.forename: Mauro
authors.initials: M
authors.lastname: Serafini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Stanzione
authors.forename: Armandodoriano
authors.initials: A
authors.lastname: Bianco
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Serilli
authors.forename: Liliana
authors.initials: L
authors.lastname: Spina
authors.forename: Rosanna
authors.initials: R
authors.lastname: Longoni
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kasture
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D029789:Ephedra / Q000737:chemistry*; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D006633:Histamine Antagonists; D010936:Plant Extracts