Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging.
We investigated the possibility of using standard commercial multimode fibers (MMF), Corning SMF28 fibers, to deliver picosecond excitation lasers for coherent anti-Stokes Raman scattering (CARS) imaging. We theoretically and/or experimentally analyzed issues associated with the fiber delivery, such as dispersion length, walk-off length, nonlinear length, average threshold power for self-phase modulations, and four-wave mixing (FWM). These analyses can also be applied to other types of fibers. We found that FWM signals are generated in MMF, but they can be filtered out using a long-pass filter for CARS imaging. Finally, we demonstrated that MMF can be used for delivery of picosecond excitation lasers in the CARS imaging system without any degradation of image quality.
Wang
Zhiyong
Z
Bioengineering and Informatics Program, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, Texas 77030, USA. Zhwang@ieee.org
Yang
Yaliang
Y
Luo
Pengfei
P
Gao
Liang
L
Wong
Kelvin K
KK
Wong
Stephen T C
ST
D000818:Animals; D003198:Computer Simulation; D004423:Ear / Q000033:anatomy & histology; D007668:Kidney / Q000033:anatomy & histology; D007834:Lasers; D051379:Mice; D055100:Optical Fibers; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods*; D013997:Time Factors