title: Extensive segmental acanthosis nigricans form of epidermal nevus.
abstract: Eight cases of the acanthosis nigricans form of epidermal nevus have been described in literature. The present case is impressive and has an extensive segmental distribution. Although etiological factors, such as mutations in the FGFR3 gene, are becoming recognized, treatment options remain limited. We present a case of a 14-year-old male with multiple hyperpigmented, hyperkeratotic plaques on the upper body, axillae, and groin with a segmental distribution following Blaschko lines. Histopathological investigation showed aspects of both acanthosis nigricans and epidermal nevus. So far, screening has not revealed any internal abnormalities. As previous cases show a clear association with internal diseases, repetitive screening for internal diseases and syndromes is suggested in the case of the acanthosis nigricans form of epidermal nevus. Treatment of the condition remains a challenge.
authors.affiliation: Department of Dermatology, The Netherlands.
authors.forename: Anne C
authors.initials: AC
authors.lastname: de Waal
authors.forename: Michelle M
authors.initials: MM
authors.lastname: van Rossum
authors.forename: H Jorn
authors.initials: HJ
authors.lastname: Bovenschen
mesh_terms: D000052:Acanthosis Nigricans / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009506:Nevus / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin