Selective binding and release of aspirin by an encapsulating receptor.
The selective binding of aspirin deep inside superbowl synthetic hosts is reported. Evidence for a two-point binding mode of the drug by the host is presented. Both the strength of aspirin binding and the rate of its release are manipulated by altering the substituents about the host's aperture.
Nguyen
Thanh V
TV
ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
Yoshida
Hiroshi
H
Sherburn
Michael S
MS
D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004337:Drug Carriers / Q000737:chemistry; D006860:Hydrogen Bonding; D008968:Molecular Conformation
D004337:Drug Carriers; D001241:Aspirin