Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study.
Since tachykinins appear to be involved in the pathogenesis of allergic asthma, we investigated a possible association between 28 single nucleotide polymorphisms of the tachykinin genes TAC1, TAC3 and TAC4, and asthma susceptibility. A case-control study was conducted on 102 patients and 100 healthy subjects from the Canary Islands (Spain). A significant association with asthma was observed for two SNPs: rs2291855 in the TAC3 gene conferring asthma protection (Odds ratio [OR]: 0.46; 95% Confidence Interval [CI]: 0.22-0.97; P=0.038), and rs4794068 in the TAC4 gene associated with an increased risk for asthma (OR: 1.94; 95% CI: 1.06-3.54; P=0.03). The present study represents a preliminary step in elucidating the association between tachykinin gene polymorphisms and asthma susceptibility.
Klassert
Tilman E
TE
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez s/n, 38271 La Laguna, Canarias, Spain. tilklass@ull.es
Sánchez
Juan J
JJ
Almeida
Teresa A
TA
Candenas
Luz
L
Pinto
Francisco
F
Acosta
Orlando
O
Hernández
Mariano
M
D001249:Asthma / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D016022:Case-Control Studies; D005786:Gene Expression Regulation / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D009479:Neuropeptides / Q000096:biosynthesis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015320:Tachykinins / Q000096:biosynthesis / Q000235:genetics*
D009479:Neuropeptides; C486037:TAC4 protein, human; D015320:Tachykinins