title: Holoprosencephaly and genitourinary anomalies in fetal methotrexate syndrome.
abstract: Prenatal exposure to methotrexate (MTX) in the first trimester may lead to fetal death, and surviving children have increased risks for cranial dysostosis, dysmorphic facies, skeletal malformations, limb defects, growth retardation, and, in some cases, developmental delay, a pattern of defects recognized as fetal MTX syndrome (FMS). We report on a male infant who, in addition to severe FMS, showed previously undescribed central nervous system (CNS) and genitourinary anomalies that contributed to the further delineation. The propositus was born to a G2, 20-year-old mother with an irregular menstrual history. The unplanned pregnancy was complicated by oral MTX treatment (5 mg/day) for suspected systemic lupus erythematosus for 14 days at the 5th week post-conception, as dated by the first trimester sonogram. In addition to the typical features of the FMS, our propositus exhibited congenital penile curvature, vesicoureteral reflux, hydronephrosis, and severe CNS anomalies including semilobar holoprosencephaly (HPE). A single previous report of lobar-type HPE in an infant with FMS led us to confirm that the HPE observed in the propositus is a feature attributable to MTX teratogenicity, although the exact mechanisms of the HPE production need to be further elucidated. Also, this case serves to highlight the presence of genitourinary anomalies in patients with FMS, a fact that requires intentional searches in future patients in order to confirm this as being characteristic of the entity.
authors.affiliation: Servicio de Genética, División de Pediatría, Nuevo Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Hospital-Escuela, Guadalajara, Jalisco, Mexico. rocorona@cucs.udg.mx
authors.forename: J Román
authors.initials: JR
authors.lastname: Corona-Rivera
authors.forename: Alejandro
authors.initials: A
authors.lastname: Rea-Rosas
authors.forename: Adrián
authors.initials: A
authors.lastname: Santana-Ramírez
authors.forename: Jorge
authors.initials: J
authors.lastname: Acosta-León
authors.forename: Juan
authors.initials: J
authors.lastname: Hernández-Rocha
authors.forename: Karla
authors.initials: K
authors.lastname: Miguel-Jiménez
mesh_terms: D000328:Adult; D002972:Cleft Palate / Q000150:complications; D005260:Female; D005333:Fetus / Q000002:abnormalities* / Q000187:drug effects*; D016142:Holoprosencephaly / Q000150:complications*; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000000981:diagnostic imaging; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D010413:Penis / Q000002:abnormalities; D011247:Pregnancy; D011859:Radiography; D012886:Skull / Q000002:abnormalities / Q000000981:diagnostic imaging; D013577:Syndrome; D014564:Urogenital Abnormalities / Q000150:complications*; D014718:Vesico-Ureteral Reflux / Q000150:complications*; D055815:Young Adult
chemical_list: D008727:Methotrexate