[Effect of nitroderivatives of fullerene C60 on amyloid fibrils of Abeta(1-42) peptide of the brain and muscle X-protein].
The antiamyloidogenic capacity of water-soluble nitroderivatives of fullerene C60: methyl ester of LN-[(2-nitroglyceryl) fullerenyl] proline, methyl ester of LN-[(2,3-dinitroglyceryl) fullerenyl] proline, and 2 nitroxyethyl ether LN-([2-(nitroxy) ethyl] fullerenyl) proline has been studied in vitro by high-resolution electron microscopy. It was shown that these fullerene C60 nitroderivatives are able to prevent the formation of amyloid fibrils by the brain Abeta(1-42)-peptide and muscle X-protein and to destroy mature fibrils. Electron microscopy is a promising method for selecting effective antiamyloidogenic drugs. The antiamyloidogenic activity of nanodimensional fullerene C60 nitroderivatives offers strong possibilities for creating a new nanotechnology for the therapy of amyloidoses.
Bobylev
A G
AG
Marsagishvili
L G
LG
Shpagina
M D
MD
Romanova
V S
VS
Kotel'nikova
R A
RA
Podlubnaia
Z A
ZA
D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry; D000818:Animals; D037741:Fullerenes / Q000737:chemistry*; D009124:Muscle Proteins / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D011817:Rabbits
C551681:2 nitroxyethyl ether LN-((2-(nitroxy)ethyl)fullerenyl)proline; D000682:Amyloid; D016229:Amyloid beta-Peptides; D037741:Fullerenes; C551680:LN-((2,3-dinitroglyceryl)fullerenyl)proline, methyl ester; C551679:LN-((2-nitroglyceryl)fullerenyl)proline, methyl ester; D009124:Muscle Proteins; D009574:Nitro Compounds; D010446:Peptide Fragments; C039728:X-Protein, muscle, Oryctolagus cuniculus; C075222:amyloid beta-protein (1-42); D011392:Proline; C069837:fullerene C60