title: Amiodarone-induced thyrotoxicosis in children and adolescents is a possible outcome in patients with low iodine intake.
abstract: OBJECTIVE
  The identification of the different subtypes of amiodarone-induced thyrotoxicosis (AIT) may provide a rational basis for the choice of the appropriate medical treatment. The aim of this study was to evaluate differential diagnosis and treatment regimens of AIT in children and adolescent.
  
  
  METHODS
  We reported 3 patients: A 6.7 years old boy with type I AIT; a 17.9 years old girl with type II AIT and a 14.6 years old girl with mixed type AIT.
  
  
  CONCLUSIONS
  AIT is not an uncommon complication in countries with low iodine intake. AIT can be asymptomatic and can occur at any time in patients receiving amiodarone therapy. It is also very important to distinguish the type of AIT when planning therapy. Steroid therapy should be started when findings indicate type II or mixed-type AIT. Beta blockers may prevent heart thyrotoxicosis and recurrence of primary arrhythmia if amiodarone is discontinued.
authors.affiliation: Ankara University School of Medicine, Department of Pediatric Endocrinology, Cebeci, Ankara, Turkey. hacihamdi@mynet.com
authors.forename: Bülent
authors.initials: B
authors.lastname: Hacihamdioğlu
authors.forename: Merih
authors.initials: M
authors.lastname: Berberoğlu
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Siklar
authors.forename: Senay
authors.initials: S
authors.lastname: Savaş Erdeve
authors.forename: Gönül
authors.initials: G
authors.lastname: Oçal
authors.forename: Ercan
authors.initials: E
authors.lastname: Tutar
authors.forename: Semra
authors.initials: S
authors.lastname: Atalay
mesh_terms: D000293:Adolescent; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D013971:Thyrotoxicosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome; D014284:Triiodothyronine / Q000097:blood
chemical_list: D000889:Anti-Arrhythmia Agents; D014284:Triiodothyronine; D000638:Amiodarone; D013974:Thyroxine