Serum uric acid level is associated with cardiac hypertrophy in renal transplant recipients.
BACKGROUND
Serum uric acid (UA) level as a significant and independent risk factor for cardiovascular disease, and the link between this marker and left ventricular hypertrophy (LVH) in renal transplant recipients remains to be clarified.


METHODS
A total of 141 renal transplant recipients (83 men), between ages of 18 and 69 (mean age 37 ± 11), were included in this single center study. In addition to demographic, clinical, and laboratory parameters, serum UA concentrations were evaluated. LVH was determined by two-dimensional and M-mode echocardiography.


RESULTS
Serum UA levels were significantly higher (6.14 ± 1.15 mg/dL) in patients with LVH (n = 54) when compared to patients (n = 87) who did not have this abnormality (5.29 ± 1.43 mg/dL) (p = 0.006). Serum UA levels were significantly correlated with septal wall thickness, LV posterior wall thickness, LV mass index (LVMI), and pulmonary arterial pressure. Multiple linear regression analysis revealed that UA predicted LVMI (r(2) = 0.150, β = 0.369, p = 0.001). However, serum creatinine (β = 0.060, p = 0.593) and age (β = 0.146, p = 0.175) were not predictors of LVMI.


CONCLUSIONS
High serum UA levels are associated with LVH in renal transplant recipients, which underlines the importance of treating hyperuricemia.
Caliskan
Yasar
Y
Department of Internal Medicine, Istanbul University Cardiology Institute, Istanbul University, Istanbul, Turkey. ykcaliskan@yahoo.com
Gorgulu
Numan
N
Yelken
Berna
B
Akturk
Faruk
F
Yazici
Halil
H
Turkmen
Aydin
A
Sever
Mehmet Sukru
MS
D000293:Adolescent; D000328:Adult; D000368:Aged; D006332:Cardiomegaly / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D003404:Creatinine / Q000097:blood; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
D014527:Uric Acid; D003404:Creatinine