The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.
The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.
Krishnakumar
Raga
R
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Kraus
W Lee
WL
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D002986:Clinical Trials as Topic; D004247:DNA / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics; D006801:Humans; D023421:Models, Animal; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000378:metabolism*
D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases