A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform.
BACKGROUND
Growing evidence shows that the etiological causes and pathological processes underlying major depressive disorder (MDD) and schizophrenia (SCZ) overlap. Our previous study revealed a strong association between the polymorphism ss178077483 in the miRNA-30e precursor (pre-miR-30e) and the risk of SCZ. We thus hypothesized that this SCZ risk allele at the pre-miR-30e gene also confers risk of MDD.


METHODS
To explore the relationship between miR-30e ss178077483 and MDD, we conducted an association analyses in 1088 MDD patients and 1102 control subjects from the Han Chinese population. We also determined the effects of miR-30e ss178077483 on the development of P300 event-related potential components induced by an auditory odd-ball task.


RESULTS
We detected a statistically significant positive association between miR-30e ss178077483 and MDD (allelic P=0.0287; genotypic P=0.0275). Moreover, the P300 latency was associated with miR-30e ss178077483 genotypes and the individuals with the C/T genotype have a longer P300 latency than those carrying the C/C genotype (P=0.009).


CONCLUSIONS
Larger numbers of subjects and different ethnic groups would confirm and strengthen these preliminary findings.


CONCLUSIONS
To our knowledge, this is the first evidence to suggest that miRNA polymorphisms may play an important role in MDD susceptibility. These findings also imply that certain miRNAs may be involved in the etiology of MDD.
Xu
Yong
Y
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Liu
Haiying
H
Li
Fei
F
Sun
Ning
N
Ren
Yan
Y
Liu
Zhifen
Z
Cao
Xiaohua
X
Wang
Yanfang
Y
Liu
Pozi
P
Zhang
Kerang
K
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002681:China; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics; D055815:Young Adult
C546086:MIRN30b microRNA, human; D035683:MicroRNAs