title: Multidetector computed tomography venography: optimum dose of contrast material.
abstract: OBJECTIVE
  The aim of this study was to determine the optimum dose of contrast material for evaluating veins in the lower limbs.
  
  
  METHODS
  A total of 134 patients who underwent multidetector computed tomography (MDCT) due to suspected deep vein thrombosis (DVT) or pulmonary embolism (PE) were included in this study. One hundred milliliters of iopamidol 100 ml, with 370 mg I/ml was administered. The degree of contrast enhancement of veins in the lower limbs was classified on a 4-point scale (grade 1, poor --> 4, excellent). Regions of interest (ROIs) were positioned in the femoral vein and the popliteal vein to measure CT numbers in these veins. Correlations between the CT number in each ROI and body weight were examined.
  
  
  RESULTS
  The mean +/- SD body weights of patients by contrast-enhancement grade were as follows: grade 1, 86.3 +/- 10.2 kg; grade 2, 72.6 +/- 10.7 kg; grade 3, 59.7 +/- 8.7 kg; grade 4, 51.3 +/- 7.9 kg. Negative correlations were found between body weight and CT number for both the femoral vein and the popliteal vein. Grade 3 or better contrast enhancement was obtained in 79 of 81 patients (97.5%) weighing <60 kg.
  
  
  CONCLUSIONS
  For patients weighing <60 kg, 100 ml of contrast material (370 mg I/ml) is considered sufficient for evaluating veins in the lower limbs.
authors.affiliation: Department of Radiology, Niigata University Medical and Dental Hospital, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Hori
authors.forename: Norihiko
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Horii
authors.forename: Toru
authors.initials: T
authors.lastname: Takano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005268:Femoral Vein / Q000000981:diagnostic imaging; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods*; D011152:Popliteal Vein / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*; D020246:Venous Thrombosis / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D007479:Iopamidol