A case of Lewis-Sumner syndrome showing dramatic improvement after plasma exchange.
We report a patient with Lewis-Sumner syndrome (LSS) who showed an improvement only with plasma exchange (PE). The patient, 32-yr old man, had progressive multifocal motor-sensory deficits with persistent, multiple conduction blocks and marked slowing of NCVs. Nerve pathology supported a diagnosis of demyelinating neuropathy by revealing marked loss of myelinated fibers with inter- and intrafascicular variation. Although the patient was refractory to treatment with corticosteroid and intravenous immunoglobulin, PE produced a dramatic improvement. Our experience strongly proposes that PE should be tried for refractory LSS.
Park
Young-Eun
YE
Department of Neurology, Pusan National University School of Medicine, Busan, Korea.
Yook
Ji-Won
JW
Kim
Dae-Seong
DS
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology; D010951:Plasma Exchange; D013577:Syndrome; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous