title: Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging.
abstract: Release mechanism of acetaminophen (AAP) from extended-release tablets of hydrogel polymer matrices containing polyethylene oxide (PEO) and polyethylene glycol (PEG) were achieved using flow-through cell with magnetic resonance imaging (MRI). The hydrogel forming abilities are observed characteristically and the layer thickness which is corresponding to the diffusion length of AAP has a good correlation with the drug release profiles. In addition, polymeric erosion contribution to AAP releasing from hydrogel matrix tablets was directly quantified using size-exclusion chromatography (SEC). The matrix erosion profile indicates that the PEG erosion kinetic depends primarily on the composition ratio of PEG to PEO. The present study has confirmed that the combination of in situ MRI and SEC should be well suited to investigate the drug release mechanisms of hydrogel matrix such as PEO/PEG.
authors.affiliation: Pharmaceutical Analysis, Pharmaceutical Research & Technology Laboratories, Technology, Astellas Pharma Inc, Yaizu, Shizuoka 425-0072, Japan. tomokazu.tajiri@jp.astellas.com
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Tajiri
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Morita
authors.forename: Ryosaku
authors.initials: R
authors.lastname: Sakamoto
authors.forename: Masazumi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yamanashi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kitamura
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002850:Chromatography, Gel; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D020100:Hydrogels; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D013607:Tablets; D000082:Acetaminophen; D011092:Polyethylene Glycols