Weight lifting in patients with lower-extremity lymphedema secondary to cancer: a pilot and feasibility study.
OBJECTIVE
To assess the feasibility of recruiting and retaining cancer survivors with lower-limb lymphedema into an exercise intervention study. To develop preliminary estimates regarding the safety and efficacy of this intervention. We hypothesized that progressive weight training would not exacerbate leg swelling and that the intervention would improve functional mobility and quality of life.


METHODS
Before-after pilot study with a duration of 5 months.


METHODS
University of Pennsylvania.


METHODS
Cancer survivors with a known diagnosis of lower-limb lymphedema (N=10) were directly referred by University of Pennsylvania clinicians. All 10 participants completed the study.


METHODS
Twice weekly slowly progressive weight lifting, supervised for 2 months, unsupervised for 3 months.


METHODS
The primary outcome was interlimb volume differences as measured by optoelectronic perometry. Additional outcome measures included safety (adverse events), muscle strength, objective physical function, and quality of life.


RESULTS
Interlimb volume differences were 44.4% and 45.3% at baseline and 5 months, respectively (pre-post comparison, P=.70). There were 2 unexpected incident cases of cellulitis within the first 2 months. Both resolved with oral antibiotics and complete decongestive therapy by 5 months. Bench and leg press strength increased by 47% and 27% over 5 months (P=.001 and P=.07, respectively). Distance walked in 6 minutes increased by 7% in 5 months (P=.01). No improvement was noted in self-reported quality of life.


CONCLUSIONS
Recruitment of patients with lower-limb-lymphedema into an exercise program is feasible. Despite some indications that the intervention may be safe (eg, a lack of clinically significant interlimb volume increases over 5 mo), the unexpected finding of 2 cellulitic infections among the 10 participants suggests additional study is required before concluding that patients with lower-extremity lymphedema can safely perform weight lifting.
Katz
Elana
E
Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA.
Dugan
Nicole L
NL
Cohn
Joy C
JC
Chu
Christina
C
Smith
Rebecca G
RG
Schmitz
Kathryn H
KH
D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008209:Lymphedema / Q000209:etiology* / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010865:Pilot Projects; D011788:Quality of Life; D055070:Resistance Training / Q000379:methods*