title: Unsuccessful treatment of recalcitrant cutaneous discoid lupus erythematosus with photodynamic therapy.
abstract: Discoid lupus erythematosus (DLE) can be a therapeutic challenge. Antimalarials and topic steroids are the first-line standard therapies, while systemic steroids, immunomodulators (as azathioprine, methotrexate, cyclosporine), retinoids (acitretin), thalidomide, auranofin and dapsone are used as second-line therapies. We report two patients with recalcitrant DLE who were treated with three and two sessions of 5-aminolevulinic photodynamic therapy without an improvement and with a bad tolerance to the therapy.
authors.affiliation: Department of Dermatology, Hospital de Fuenlabrada, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Romero-Maté
authors.forename: Esther
authors.initials: E
authors.lastname: Castaño-Suárez
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Donoso
authors.forename: Cristina
authors.initials: C
authors.lastname: Martínez-Morán
authors.forename: Carmen
authors.initials: C
authors.lastname: Meseguer-Yebra
authors.forename: Jesús
authors.initials: J
authors.lastname: Borbujo
mesh_terms: D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D016896:Treatment Outcome