Acupressure using ondansetron versus metoclopramide on reduction of postoperative nausea and vomiting after strabismus surgery.
OBJECTIVE
To compare the clinical efficacy of acupressure with treatment induced by ondansetron and metoclopramide on reduction of the severity of postoperative nausea and vomiting (PONV) after strabismus surgery.


METHODS
There were 200 patients with ASA classes I-II, ages 10 to 60 years old, who underwent strabismus surgery that were included in this randomized, prospective, double-blind, placebo-controlled trial. Group I was the control, group II received metoclopramide 0.2 mg/kg, and group III received ondansetron 0.15 mg/kg intravenously immediately prior to anesthesia induction. In Group IV, acupressure wristbands were applied at the P6 points. Acupressure wrist bands were not placed appropriately for subjects of groups I-III. The acupressure wrist bands were applied 30 minutes before anesthesia induction and removed six hours after surgery completion. Anesthesia was standardized. PONV was evaluated within 0 - 2 hours and 2 - 24 hours after surgery by a blinded observer. Results were analyzed by the Chi-square or Fisher exact test. A P value of <0.05 was considered significant.


RESULTS
The incidence of PONV was not significantly different among acupressure, metoclopramide and ondansetron groups during 24 hours. Also, the severity of PONV was not significantly different between acupressure, metoclopramide, and ondansetron in the recovery and ward.


CONCLUSIONS
Acupressure at the P6 point causes a significant reduction in the incidence and severity of PONV 24 hours after strabismus surgery as well as metoclopramide (0.2 mg/kg) and ondansetron (0.15 mg/kg) intravenous for patients aged 10 or older. (Irct ID: IRCT138807152556N1).
Ebrahim Soltani
Alireza
A
Department of Anesthesiology, Children Medical Center, Tehran, Iran.
Mohammadinasab
Hossein
H
Goudarzi
Mehrdad
M
Arbabi
Shahriar
S
Mohtaram
Robab
R
Afkham
Khosro
K
Momenzadeh
Sirus
S
Darabi
Mohammad Esmaeil
ME
D019050:Acupressure / Q000379:methods*; D000293:Adolescent; D000932:Antiemetics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007492:Iran / Q000453:epidemiology; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D017294:Ondansetron / Q000008:administration & dosage*; D013508:Ophthalmologic Surgical Procedures; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology / Q000628:therapy*; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
D000932:Antiemetics; D017294:Ondansetron; D008787:Metoclopramide