Diterpenoids from Pinus massoniana resin and their cytotoxicity against A431 and A549 cells.
Five diterpenoids and 14 known diterpenoids were isolated from the petroleum ether extract of Pinus massoniana resin. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that three of the less polar diterpenoids had strong cytotoxicity against A431 and A549 cancer cells, whereas those of high polarity had none.
Yang
Nian-Yun
NY
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
Liu
Li
L
Tao
Wei-Wei
WW
Duan
Jin-Ao
JA
Tian
Li-Juan
LJ
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D028223:Pinus / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D004224:Diterpenes; D012116:Resins, Plant