title: Childhood, adolescent, and young adult cancer survivors research program of British Columbia: objectives, study design, and cohort characteristics.
abstract: BACKGROUND
  The Childhood, Adolescent, and Young Adult Cancer Survivors Research Program (CAYACS) has been established in the province of British Columbia (BC), Canada, to carry out research into late effects and survivor care in multiple domains, and to inform policy and practice.
  
  
  METHODS
  This program identifies a survivor cohort and comparison groups from population-based registries and links their records to population-based files of outcomes and outcome determinants, to create a research database and conduct studies of long-term outcomes and care.
  
  
  RESULTS
  The initial cohort consisted of all 5-year survivors of cancer or a tumor diagnosed under age 25 years from 1970 to 1995, who were residents in BC at the time of diagnosis, and followed till 2000 (3,841 subjects). Seven percent have died, and 77% have treatment information available. Data on death and second cancer occurring in BC are available. Late morbidity and healthcare utilization information is available for 68% of survivors (79% of those diagnosed from 1981). Education outcomes are available for 71% of those born during 1978-1995 and diagnosed under age 15 years.
  
  
  CONCLUSIONS
  Use of registries, administrative databases, and record linkage methodologies is a cost-effective and comprehensive means to conduct survivorship research. This program should add to knowledge of risks of late effects and impacts on care, inform development of strategies to manage risks, evaluate the effects of surveillance and interventions, and assess new risks as the cohort ages, more recent survivors enter the cohort, and treatments change.
authors.affiliation: Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, BC, Canada. mmcbride@bccrc.ca
authors.forename: Mary L
authors.initials: ML
authors.lastname: McBride
authors.forename: Paul C
authors.initials: PC
authors.lastname: Rogers
authors.forename: Sam B
authors.initials: SB
authors.lastname: Sheps
authors.forename: Victor
authors.initials: V
authors.lastname: Glickman
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Broemeling
authors.forename: Karen
authors.initials: K
authors.lastname: Goddard
authors.forename: Joan
authors.initials: J
authors.lastname: Hu
authors.forename: Maria
authors.initials: M
authors.lastname: Lorenzi
authors.forename: Stuart
authors.initials: S
authors.lastname: Peacock
authors.forename: Sheila
authors.initials: S
authors.lastname: Pritchard
authors.forename: Shahrad Rod
authors.initials: SR
authors.lastname: Rassekh
authors.forename: Linda
authors.initials: L
authors.lastname: Siegel
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Paulos
authors.initials: P
authors.lastname: Teckle
authors.forename: Lijing
authors.initials: L
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D001955:British Columbia; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008498:Medical Record Linkage; D009369:Neoplasms / Q000453:epidemiology*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D044382:Population Groups; D012042:Registries; D012107:Research Design; D017741:Survivors; D055815:Young Adult