title: Impact of gluten withdrawal on health-related quality of life in celiac subjects: an observational case-control study.
abstract: OBJECTIVE
  To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD).
  
  
  METHODS
  We enrolled 43 adult CD patients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD.
  
  
  RESULTS
  At the time of diagnosis CD patients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CD patients had lower SF-36 scores than controls, while DH patients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CD patients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CD patients improved their SF-36 scores and reached values comparable to those of controls.
  
  
  CONCLUSIONS
  At diagnosis, CD patients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CD patients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception.
authors.affiliation: University of Milan, Milan, Italy. gianeugeniotontini@libero.it
authors.forename: Gian Eugenio
authors.initials: GE
authors.lastname: Tontini
authors.forename: Emanuele
authors.initials: E
authors.lastname: Rondonotti
authors.forename: Valeria
authors.initials: V
authors.lastname: Saladino
authors.forename: Simone
authors.initials: S
authors.lastname: Saibeni
authors.forename: Roberto
authors.initials: R
authors.lastname: de Franchis
authors.forename: Maurizio
authors.initials: M
authors.lastname: Vecchi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002446:Celiac Disease / Q000178:diet therapy*; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D016896:Treatment Outcome