[Ribavirin prophylaxis and therapy of experimental West Nile fever].
Investigation of the efficacy of ribavirin against the West Nile virus in standard cell cultures showed that in high concentrations it inhibited the virus reproduction (the inhibition coefficient of 100%). In the experiments on albino mice infected with the West Nile virus in a dose of 10 LD50 ribavirin was used in the form of injections in a dose of 20 mg/kg for 7 days in the scheme of urgent prophylaxis and proved to be highly efficient in protection of the animals from death (85-percent survival).
Loginova
S Ia
SIa
Borisevich
S V
SV
Pashchenko
Iu A
IuA
Bondarev
V P
VP
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D051379:Mice; D012254:Ribavirin / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D014901:West Nile Fever / Q000188:drug therapy* / Q000517:prevention & control*; D014902:West Nile virus / Q000502:physiology*
D000998:Antiviral Agents; D012254:Ribavirin