Desmopressin stimulates bile secretion in anesthetized rats.
One of the synthetic analogues of antidiuretic hormone-desmopressin is used in patients with central diabetes insipidus and in those with coagulation disorders. However, its effects on bile secretion are not fully defined. We investigated the effect of desmopressin on bile formation and determined the role of V1a vasopressin receptors in the action of desmopressin on choleresis. Rats were injected intraportally with a bolus of desmopressin; the changes of bile flow, the content of free and conjugated cholates were compared with control animal group. Selective antagonist of V1a receptors was injected 10 minutes before desmopressin treatment and the findings were compared with the results after desmopressin injection alone. Desmopressin increased bile flow, secretion of total cholates like amino acids conjugated, while diminished free bile acids content. Secreted bile volume and conjugated bile acids content were reduced in V1a receptors antagonist+desmopressin-treated rats. In contrast, free bile acids content was more than the results in desmopressin-treated rats. Desmopressin at concentrations nearly equal to physiological concentrations of natural hormone in blood shows its choleretic effect. Antagonist of V1a vasopressin receptors modulates desmopressin action. This certifies the role of these receptors in the action of desmopressin on different processes of bile formation.
Ghazaee
Sepideh Parchami
SP
Department of Human and Animal Physiology, Faculty of Biology, National Taras Schevchenko University of Kyiv, Volodymyrska 64, 01601 Kyiv, Ukraine. SEP_PAR_71@yahoo.com
Gorenko
Zoya A
ZA
Karbovska
Ludmila S
LS
Veselsky
Stanislav P
SP
Yanchuk
Petro I
PI
Makarchuk
Mykola Y
MY
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001646:Bile / Q000187:drug effects* / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000502:physiology; D014667:Vasopressins / Q000502:physiology
D065092:Antidiuretic Hormone Receptor Antagonists; D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D017483:Receptors, Vasopressin; D014667:Vasopressins; D003894:Deamino Arginine Vasopressin