Coexistence of primary pulmonary Hodgkin lymphoma and gastric MALT lymphoma associated with Epstein-Barr virus infection: a case report.
We describe a 66-year-old woman with Epstein-Barr virus-associated lymphoproliferative disorder with lung and gastric tumors. We identified two lung tumors measuring 13 and 20 mm in diameter that consisted of CD30-, CD15-, and CD20-positive Hodgkin- and Reed-Sternberg-like cells and heterogeneous cellular infiltrates in a pronounced nodular pattern, with necrosis and vasculitis, diagnosed as nodular sclerosis classical Hodgkin lymphoma. A gastric tumor showed low-grade extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type. Neoplastic cells in all tumors expressed Epstein-Barr virus-encoded RNA based on in situ hybridization. The present case is a rare composite lymphoma arising from different extranodal organs, associated with EBV infection. Her medical history included gamma-knife therapy for clinical diagnosis with a suspicion of cerebral lymphoma.
Oka
Kuniyuki
K
Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Shinonaga
Mayumi
M
Nagayama
Reizo
R
Kashimura
Hiroshi
H
Yonekawa
Nobuo
N
Tatebe
Sho
S
Kuraoka
Setsuo
S
Yatabe
Yasushi
Y
Mori
Naoyoshi
N
D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology* / Q000821:virology; D006801:Humans; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000473:pathology* / Q000821:virology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000821:virology; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000821:virology; D013274:Stomach Neoplasms / Q000473:pathology* / Q000821:virology