Manganese superoxide dismutase vs. p53: regulation of mitochondrial ROS.
Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis, and many signaling molecules and transcription factors are regulated by mitochondria-derived reactive oxygen species (ROS) to carry out this interorganellar communication. The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and -independent mechanisms at both the nucleus and mitochondria. p53 affect mitochondrial ROS production, in part, by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production, and a breakdown of communication amongst mitochondria, p53, and the nucleus can have broad implications in disease development.
Holley
Aaron K
AK
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, United States.
Dhar
Sanjit Kumar
SK
St Clair
Daret K
DK
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D013482:Superoxide Dismutase