title: CT-guided needle biopsy performed with modified coaxial technique in the diagnosis of malignant lymphomas.
abstract: OBJECTIVE
  The aim of was study was to evaluate the accuracy of computed tomography (CT)-guided core needle biopsy (CNB) performed by modified coaxial technique as an alternative tool to surgical biopsy in patients with suspected malignant lymphoma.
  
  
  METHODS
  Between May 2005 and December 2008, 67 CT-guided CNB of deep lesions were performed on 64 patients with suspected malignant lymphoma. In 19 out of 64 patients (29.7%), recurrent lymphoma was suspected. A modified coaxial technique was used in all cases, and multiple samples were obtained for histological and immunohistochemical studies.
  
  
  RESULTS
  A diagnosis of malignant lymphomas with specification of subtype according to the World Health Organization (WHO) classification was established in 41/67 cases. Other malignant neoplasms were found in 13/67, lymphoma without subtype specification was diagnosed in 7/67, whereas no conclusive diagnosis could be established in 6/67 cases. Overall diagnostic accuracy was 80.1%. In patients with a final diagnosis of malignant lymphoma, accuracy was 75.9%. No complications occurred.
  
  
  CONCLUSIONS
  Percutaneous CT-guided CNB is a safe, effective and reliable tool in the management of lymphomas in patients without superficial lymphadenopathy and can be considered an alternative approach to surgical sampling. The modified coaxial technique represents an effective tool that has a good diagnostic accuracy value with a low complication rate.
authors.affiliation: Di.M.I.M.P. - Sezione di Diagnostica per Immagini, Policlinico Universitario, Piazza Giulio Cesare 11, Bari, Italy. pasqpedo@tin.it
authors.forename: P
authors.initials: P
authors.lastname: Pedote
authors.forename: F
authors.initials: F
authors.lastname: Gaudio
authors.forename: M
authors.initials: M
authors.lastname: Moschetta
authors.forename: A
authors.initials: A
authors.lastname: Cimmino
authors.forename: G
authors.initials: G
authors.lastname: Specchia
authors.forename: G
authors.initials: G
authors.lastname: Angelelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015641:Radiography, Interventional / Q000379:methods*; D014057:Tomography, X-Ray Computed