Low serological positivity in patients with histology compatible with celiac disease in Perú.
OBJECTIVE
To study the frequency of positive serology for celiac disease (CD) in patients with duodenal biopsies suggestive of this disease.


METHODS
Cross sectional study. We included patients with duodenal biopsies histologically compatible with CD and antigliadin, antiendomysial and IgA antitransglutaminase antibodies. We defined a "case" of CD if there was a positive biopsy and either antiendomisial or antitransglutaminase positive antibodies.


RESULTS
Thirty one patients were included in our study. Six were antiendomysial positive and 5 antitransglutaminase positive while the antigliadin was positive in 14 cases. Therefore, out of 31 patients only 10 had a serology compatible with CD and only one had positive both antibodies, antiendomysial and antitransglutaminase.


CONCLUSIONS
a) We have found that most of the duodenal biopsies compatible with CD are not diagnosed with positive serology; and b) we found a low correlation between serological diagnostic tests.
Arévalo
F
F
Servicio de Anatomía Patológica, Hospital Daniel Alcides Carrión, Lima, Perú. fer13013@hotmail.com
Roe
E
E
Arias-Stella-Castillo
J
J
Cárdenas
J
J
Montes
P
P
Monge
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002446:Celiac Disease / Q000097:blood* / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru; D012698:Serologic Tests; D055815:Young Adult