title: Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor.
abstract: We report the case of a patient who developed a desmoid tumor following total proctocolectomy and J-pouch reconstruction that was unresponsive to any medical treatment. Based on estrogen receptor alpha (ERalpha) and progesterone receptor (PR) evaluation (ERalpha-negative, but PR-positive), treatment with mifepristone, a pure antiprogesterone drug, was initiated, and partial tumor regression was achieved.
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Zerifin, Israel. FredricaG@asaf.health.gov.il
authors.forename: A
authors.initials: A
authors.lastname: Halevy
authors.forename: I
authors.initials: I
authors.lastname: Samuk
authors.forename: Z
authors.initials: Z
authors.lastname: Halpern
authors.forename: L
authors.initials: L
authors.lastname: Copel
authors.forename: J
authors.initials: J
authors.lastname: Sandbank
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000601:surgery*; D000328:Adult; D000714:Anastomosis, Surgical / Q000379:methods; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D018222:Desmoid Tumors / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D015735:Mifepristone / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D016737:Proctocolectomy, Restorative / Q000379:methods; D011980:Receptors, Progesterone / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000627:therapeutic use*
chemical_list: D011980:Receptors, Progesterone; D015735:Mifepristone; D014747:Vinblastine