(99m)Tc-labeled-1-thio-beta-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis.
OBJECTIVE
The aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-beta-d-glucose radiolabeled with technetium-99m.


METHODS
The method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of (99m)Tc-1-TG and kinetic scintigraphy imaging.


RESULTS
Results show a significant difference of (99m)Tc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of (99m)Tc-1-TG by images showed the kidneys' excretion.


CONCLUSIONS
As conclusion, (99m)Tc-1-TG is a helpful tool in TMJ inflammatory process detection.
Brasileiro
Cláudia Borges
CB
Departamento de Engenharia Nuclear--PCA, Escola de Engenharia, Universidade Federal de Minas Gerais (UFMG)--Avenida Presidente Antônio Carlos, 6627, CEP: 31270-100 Belo Horizonte, MG, Brazil. cbbrasileiro@gmail.com
Pacheco
Cinthia Mara da Fonseca
CM
Queiroz-Junior
Celso Martins
CM
de Lima
Carla Flávia
CF
da Silva
Juliana Batista
JB
de Campos
Tarcísio Passos Ribeiro
TP
D000818:Animals; D005947:Glucose / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D051381:Rats; D013705:Temporomandibular Joint Disorders / Q000175:diagnosis*
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D005947:Glucose