title: Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery.
abstract: The incorporation of affinity baits into N-isopropylacrylamide-hydrogel-based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Luchini
authors.forename: Caterina
authors.initials: C
authors.lastname: Longo
authors.forename: Virginia
authors.initials: V
authors.lastname: Espina
authors.forename: Emanuel F
authors.initials: EF
authors.lastname: Petricoin
authors.forename: Lance A
authors.initials: LA
authors.lastname: Liotta