title: A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
abstract: A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.
authors.affiliation: DISMA, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Gattinoni
authors.forename: Chiara De
authors.initials: CD
authors.lastname: Simone
authors.forename: Sabrina
authors.initials: S
authors.lastname: Dallavalle
authors.forename: Filomena
authors.initials: F
authors.lastname: Fezza
authors.forename: Raffaella
authors.initials: R
authors.lastname: Nannei
authors.forename: Natalia
authors.initials: N
authors.lastname: Battista
authors.forename: Patrizia
authors.initials: P
authors.lastname: Minetti
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Quattrociocchi
authors.forename: Antonio
authors.initials: A
authors.lastname: Caprioli
authors.forename: Franco
authors.initials: F
authors.lastname: Borsini
authors.forename: Walter
authors.initials: W
authors.lastname: Cabri
authors.forename: Sergio
authors.initials: S
authors.lastname: Penco
authors.forename: Lucio
authors.initials: L
authors.lastname: Merlini
authors.forename: Mauro
authors.initials: M
authors.lastname: Maccarrone
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D010091:Oximes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D063385:Cannabinoid Receptor Modulators; D002219:Carbamates; D004791:Enzyme Inhibitors; D010091:Oximes; D000099252:Fatty Acid Amide Hydrolases