title: Extreme hyperkalaemia caused by concomitant use of a NSAID and an ace inhibitor in an elderly patient.
abstract: Extreme hyperkalaemia is a life-threatening electrolyte disorder. It is relatively common in patients with severe renal insufficiency. This report describes a case of extreme hyperkalaemia caused by drugs in an 82-year-old female patient without severe renal insufficiency, who was successfully treated without haemodialysis. The patient had been treated for arterial hypertension and type 2 diabetes mellitus for 30 years. Over the last years she had been receiving enalapril and metformin. Three weeks before the admission to the hospital, she was receiving a non-steroidal anti-inflammatory drug (NSAID) because of the back pain. She was admitted to hospital due to a collapse and weakness in the limbs. Laboratory tests showed extreme hyperkalaemia, high blood sugar, metabolic acidosis, elevated serum creatinine and blood urea nitrogen (BUN), and a slightly elevated serum sodium. On ECG, we noticed typical signs of hyperkalaemia.The patient was treated with a slow intravenous bolus of calcium gluconate and intravenous infusion of sodium chloride with insulin, glucose with insulin and sodium bicarbonte. After the treatment, all laboratory findings normalised together and the patient felt better. This case shows that physicians should be very careful when prescribing NSAIDs to elderly patients treated with drugs that affect renal function.
authors.affiliation: Department of Internal Medicine, General Hospital Brezice, Brezice, Slovenia. dinko.rogulj@zg.t-com.hr
authors.forename: Dinko
authors.initials: D
authors.lastname: Rogulj
authors.forename: Marko
authors.initials: M
authors.lastname: Hauptfeld
authors.forename: Mojca Savnik
authors.initials: MS
authors.lastname: Iskra
authors.forename: Vanda Kostevc
authors.initials: VK
authors.lastname: Zorko
authors.forename: Milena
authors.initials: M
authors.lastname: Strasek
mesh_terms: D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac