[An outline on the phylogenetic history of metazoa aging phenomenon (to the study of creating a common metazoa aging theory)].
The evolution of aging phenomenon in Metazoa was from the very beginning developing from potentially immortal forms to those more prone to aging. Potential immortality is an ancestral feature gradually lost in the course of evolution; at the same time aging and death resulting from aging are not obligatory but highly desirable property of existence of Metazoa with gamogenesis; this is a prerequisite of evolutionary progress as it facilitates species formation processes accelerating phylogenetic groups radiation and thus gives certain outlying evolutionary advantages, namely, accelerating the evolutionary process and the speed of substitution of one species by others. The main principle of aging phenomenon evolution is as follows: it's the substitution of internal factors of death of nonaging Metazoa with external ones programmed in genome. Aging mechanisms add up to limitation of repairing and regeneration capabilities of adult phenotype and/or by extermination of the whole pool of stem cells or its part only. Aging is a holistic process and it can't be drawn down to one of the known cellular processes which in their turn can't be the initial trigger of this process that is programmed in the genome in a vague form (there is no aging program as it is): if at some stage of ontogenesis the reparation mechanism disablement is genetically programmed then this is really the aging phenomenon programming. Mainly full or partial postmitotic design of an organism is programmed, and it is in its turn a factor securing the "harmfulness" of cellular mechanisms, decreasing the physiological potential of an organism with age. By this it increases the chances of mortality among Metazoa species. On the whole the presented material points to the fact that to develop a common aging theory of Metazoa we don't have to substantially replenish the database of biological science, but we need a new understanding of known facts, which determine the initial cognitive position.
Boĭko
A G
AG
Labas
Iu A
IuA
Gordeeva
A V
AV
D000375:Aging; D000818:Animals; D008962:Models, Theoretical; D010802:Phylogeny; D013045:Species Specificity