TMSG-1 and its roles in tumor biology.
TMSG-1 is a newly discovered tumor metastasis suppressor gene, which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide, but the underlying mechanism remains unknown. Studies on TMSG-1 are limited worldwide, and only a research group in Shanghai and our group have recently studied on it. As a new research field, the function of TMSG-1 remains to be explored. This review discusses the discovery of TMSG-1, structure of its encoded protein, its roles and possible mechanism in inhibiting tumor invasion and metastasis.
Xu
Xiao-Yan
XY
Peking University Health Science Center Department of Pathology, School of Basic Medical Sciences, Beijing 100191, PR China.
Pei
Fei
F
You
Jiang-Feng
JF
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002518:Ceramides / Q000138:chemical synthesis / Q000494:pharmacology*; D004789:Enzyme Activation; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D051049:Sphingosine N-Acyltransferase / Q000378:metabolism* / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism* / Q000502:physiology; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
D002518:Ceramides; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins; C438311:CERS2 protein, human; D051049:Sphingosine N-Acyltransferase; D025262:Vacuolar Proton-Translocating ATPases