title: Risk factors of mortality in non-trauma exsanguinating patients that require damage control laparotomy.
abstract: BACKGROUND
  Since introduction of damage control (DC) approach to non-trauma setting is relatively late, the risk factors associated with this procedure remain undefined. This study was aimed at identifying factors responsible for the mortality.
  
  
  METHODS
  Over a 5-year period (from February 2002 to February 2007), consecutive non-trauma patients who required DC laparotomy (DCL) with gauze packing for control of indomitable abdominal haemorrhage in our institute were included. Clinical, laboratorial and operative factors influencing in-hospital or 30-day mortality were analysed.
  
  
  RESULTS
  A total of 26 patients underwent DCL with packing in an attempt to control severe abdominal haemorrhage. There were seven (26.9%) deaths in hospital or within 30 days of DCL. Increase in age, higher initial physiological score and operative severity score assessed by the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity scoring system, lower initial body temperature, lower initial platelet (PLT) counts, greater intra-operative blood loss, presence of perioperative multiple organ dysfunction syndrome were all associated with increased risk of mortality on univariate analysis (P < 0.05). On multivariate analysis, only decrease in PLT counts (P = 0.042, OR = 0.969, 95% CI = 0.940-0.999) and increase in age (P = 0.035, OR = 1.152, 95% CI = 1.010-1.313) were significant independent factors affecting mortality.
  
  
  CONCLUSIONS
  Decrease in PLT counts and increase in age are the independent risk factors related to death in non-trauma series that require DCL with packing. DCL should be performed early as for patients with these risk factors.
authors.affiliation: Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
authors.forename: Wen-bo
authors.initials: WB
authors.lastname: Zhang
authors.forename: Wei-ya
authors.initials: WY
authors.lastname: Wang
authors.forename: Ge-fei
authors.initials: GF
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Jie-shou
authors.initials: JS
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002423:Cause of Death; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D058734:Exsanguination / Q000097:blood / Q000401:mortality* / Q000601:surgery*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007813:Laparotomy / Q000379:methods; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010976:Platelet Count; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D055815:Young Adult