Interactions among related genes of renin-angiotensin system associated with type 2 diabetes.
OBJECTIVE
To explore the association between epistasis among related genes of the renin-angiotensin system (RAS) and type 2 diabetes.


METHODS
Gene polymorphisms were genotyped in 394 type 2 diabetic patients and 418 healthy control subjects in this case-control study. We used the multifactor dimensionality reduction method to identify gene-gene interactions.


RESULTS
No single locus was associated with type 2 diabetes, except for the insert/deletion (I/D) polymorphism of the ACE gene in female subjects. In multi-locus analyses, in male subjects the model of rs2106809 (ACE2), rs220721 (Mas), rs699 (AGT), and I/D (ACE) was significant (P = 0.043). This combination was associated with a 4.00 times (95% CI 2.51-6.38; P < 0.0001) greater prevalence of type 2 diabetes. In female subjects, the model of rs2106809 (ACE2), I/D (ACE), and rs1403543 (AGTR2) was significant (P = 0.012). This three-locus combination was associated with a 2.76 times (1.91-3.97; P < 0.0001) greater prevalence of type 2 diabetes.


CONCLUSIONS
Interactions among RAS-related genes were associated with type 2 diabetes in a Chinese population.
Yang
Jin-Kui
JK
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. jinkui.yang@gmail.com
Zhou
Jian-Bo
JB
Xin
Zhong
Z
Zhao
Lei
L
Yu
Mei
M
Feng
Jian-Ping
JP
Yang
Hui
H
Ma
Ya-Hong
YH
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A