title: Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria.
abstract: Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA.
authors.affiliation: Universidade Nova de Lisboa, Rua da Junqueira, 96, 1349-008 Lisboa, Portugal.
authors.forename: Bianor
authors.initials: B
authors.lastname: Valente
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Campos
authors.forename: Virgílio E
authors.initials: VE
authors.lastname: do Rosário
authors.forename: Henrique
authors.initials: H
authors.lastname: Silveira
mesh_terms: D000293:Adolescent; D000328:Adult; D000810:Angola; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016778:Malaria, Falciparum / Q000201:enzymology / Q000235:genetics*; D010920:Placenta; D010922:Placenta Diseases / Q000235:genetics*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000235:genetics*; D015238:Sulfotransferases / Q000235:genetics*; D055815:Young Adult
chemical_list: D015238:Sulfotransferases; C019893:chondroitin 4-sulfotransferase