title: Diterpenoids from Pinus massoniana resin and their cytotoxicity against A431 and A549 cells.
abstract: Five diterpenoids and 14 known diterpenoids were isolated from the petroleum ether extract of Pinus massoniana resin. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that three of the less polar diterpenoids had strong cytotoxicity against A431 and A549 cancer cells, whereas those of high polarity had none.
authors.affiliation: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Tao
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Tian
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D028223:Pinus / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D012116:Resins, Plant