A method for investigating cortical control of stand and squat in conscious behavioral monkeys.
Technical challenges to record cortical unit spikes in conscious behavior monkeys have been presenting constraints in the investigation of cortical control of lower limb. Here we report a novel experimental system for investigation of correlation between cortical neuronal signals and standing and squatting movement. The system consists of a specially designed chair, a standing and squatting task training paradigm and a neuron recording setup with microdrivable electrodes. With this system, a monkey can perform standing up and squatting down tasks while the head is relatively stationary to allow accurate single cortical unit recordings. The spike activities of single motor cortical units, the kinematics and muscle activities from monkeys functioning lower limb motion tasks were successfully recorded simultaneously for analyses of cortical control of lower limb functions and correlations between activity patterns of cortical neurons and lower limb muscles.
Ma
Chaolin
C
Center for Neural Interface Design, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA.
He
Jiping
J
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D001696:Biomechanical Phenomena / Q000502:physiology; D004567:Electrodes, Implanted; D004576:Electromyography / Q000379:methods; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D035002:Lower Extremity / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D009044:Motor Cortex / Q000166:cytology*; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D014584:User-Computer Interface; D014851:Wakefulness / Q000502:physiology*