[Microencapculation of daunorubicin with biodegradable polymer matrix].
Procedure for microencapsulation providing stable formation of high quality microspheres was designed. Conditions for deposition of the anthracycline antibiotic daunorubicin to polymer matrix were developed and microsheres loaded with various quantities of the drug were prepared. The kinetics of the in vitro and in vivo release of daunorubicin from the microsheres was studied. The rate of the rubomycin release to the medium in vitro (balanced phosphate buffer at 37.8 degrees C) in a 300-hour experiment directly depended on the quantity of the incorporated drug and averaged 0.81 x 10(-4) to 2.3 x 10(-4) mcg/ml x h. The experiment on laboratory animals with intraperitoneal administration of the rubomycin microsperes showed that the drug remained in the blood and abdominal liquid for a long time (up to 10 days). Possible control of the quantity of the rubomycin encapsulation to the polymer matrix, no sharp efflux of the drug at the early stages of the observation and low rate of the drug release to the medium allowed to conclude that the use of the biodegradable polymer microsperes as carriers of the high toxic antibiotic providing its prolonged action was prospective.
Shshatskaia
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D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000493:pharmacokinetics*; D002214:Capsules; D003630:Daunorubicin / Q000737:chemistry* / Q000493:pharmacokinetics*; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D002214:Capsules; D011091:Polyesters; D003630:Daunorubicin