title: A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents.
abstract: A labdane diterpene dialdehyde was first time isolated from the chloroform extract of rhizomes of Curcuma amada. This compound exhibited antitubercular activity (MIC=500 microg/mL) against Mycobacterium tuberculosis H(37)Rv strain in BACTEC-460 assay. Two of its semisynthetic analogues also exhibited antitubercular activity at 250-500 microg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada.
authors.affiliation: Plant Tissue Culture Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India.
authors.forename: Sailendra
authors.initials: S
authors.lastname: Singh
authors.forename: Jonnala Kotesh
authors.initials: JK
authors.lastname: Kumar
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Saikia
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.forename: Jay Prakash
authors.initials: JP
authors.lastname: Thakur
authors.forename: Arvind Singh
authors.initials: AS
authors.lastname: Negi
authors.forename: Suchitra
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D030024:Curcuma / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D004224:Diterpenes