Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells.
Telomerase activity in HIV-1-specific CD8(+) T cells from controllers contributes to the maintenance of highly functional cytotoxic T cell responses against HIV-1. Here, we show that high expression of telomerase in controllers is associated with hypermethylation at the distal and hypomethylation at the proximal human telomerase catalytic subunit promoter, whereas HIV-1-specific CD8(+) T cells from progressors showed an inverse pattern with distal promoter hypomethylation and proximal promoter hypermethylation. These data suggest distinct epigenetic signatures in HIV-1-specific T cells in progressors and controllers.
Williams
Katie
K
Ragon Institute of MGH, Harvard, Massachusetts Institute of Technology, Boston, Massachusetts 02114, USA.
Seiss
Katherine
K
Beamon
Jill
J
Pereyra
Florencia
F
Rosenberg
Eric S
ES
Walker
Bruce D
BD
Yu
Xu G
XG
Lichterfeld
Mathias
M
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019098:Telomerase / Q000235:genetics / Q000276:immunology*; D019562:Viral Load
D019098:Telomerase