Probiotic administration effect on fecal mutagenicity and microflora in the goat's gut.
The application of potentially beneficial microorganisms to increase host defense is a new trend to increase health benefits. In this paper the first specific host probiotics for goats from a mixture isolated from healthy animals (Lactobacillus reuteri DDL 19, Lactobacillus alimentarius DDL 48, Enterococcus faecium DDE 39 and Bifidobacterium bifidum DDBA) was assayed. The effect of probiotic oral administration on goats' weight, gut microbiota, as well as on the production of mutagen compounds and their indicator (putrescine), were evaluated. The probiotic supplement was able to modify microflora balance by reducing Enterobacteria like Salmonella/Shigella (1.09 and 1.21 log CFU/g feces, respectively) and increasing lactic acid bacteria and Bifidobacteria (1.67 and 2.34 log CFU/g feces, respectively). The probiotics administration was correlated with a ten time diminution of fecal putrescine (cancer and bacterial disease marker) and a decrease of 60% mutagen fecal concentration, indicating the protective effect of the treatment. Additionally, a significant increase in ruminant weight was observed after probiotic administration. These results are encouraging towards the use of probiotic mixtures as functional food for goats.
Apás
Ana Lidia
AL
Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán (UNT), Ayacucho 471, 4000, Tucumán, Argentina.
Dupraz
Javier
J
Ross
Romina
R
González
Silvia Nelina
SN
Arena
Mario Eduardo
ME
D000284:Administration, Oral; D000818:Animals; D058491:Bacterial Load; D001709:Biotechnology; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology; D006041:Goats / Q000378:metabolism* / Q000382:microbiology*; D054892:Metagenome; D009153:Mutagens / Q000378:metabolism*; D019936:Probiotics / Q000008:administration & dosage*; D011700:Putrescine / Q000378:metabolism
D009153:Mutagens; D011700:Putrescine