Elevated plasma levels of chemerin in newly diagnosed type 2 diabetes mellitus with hypertension.
Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome.
Yang
Mengliu
M
Department of Clinical Biochemistry and Key Laboratory of Laboratory Medical Diagnostics in Ministry of Education, Chongqing Medical University, Chongqing, China.
Yang
Gangyi
G
Dong
Jing
J
Liu
Ying
Y
Zong
Haihong
H
Liu
Hua
H
Boden
Guenther
G
Li
Ling
L
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D018925:Chemokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism; D055105:Waist Circumference / Q000502:physiology
D018925:Chemokines; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; D019707:Receptors, Chemokine; C102741:CMKLR1 protein, human; C478630:RARRES2 protein, human; C517652:hemoglobin A1c protein, human