title: [The nonlinear relationship between the resuscitation therapy and intensive insulin therapy in severe sepsis and septic shock patients].
abstract: OBJECTIVE
  To study the relationship between the resuscitation therapy and intensive insulin therapy on stress-induced hyperglycemia in severe sepsis and septic shock patients, and to evaluate the value on nonlinear viewpoint in the treatment of patients with sepsis.
  
  
  METHODS
  The data of 129 hospitalized patients with severe sepsis and septic shock were analyzed and they were divided into eight groups every 6 hours in ascending order for full recovery. The resuscitation therapy time of each group was compared with insulin dosage in each unit time with nonlinear least square method.
  
  
  RESULTS
  The relationship of the exponential function fit very well between the resuscitation therapy time of each group and the insulin dosage in each unit time. The exponential curve equation was y=e0.739 3-0.015 2x2 (a=0.739 3, b=0.015 2) and the curve fit very well (R2=0.976 943 6).
  
  
  CONCLUSIONS
  It conforms to the nonlinear viewpoint that the resuscitation therapy time is closely correlated with recovery of dysfunction of endocrine system during the treatment for patients with severe sepsis and septic shock. Therefore, the essence of successful treatment is to concentrate on helping the body rebuild the disorganized network and the recovery of physiological harmony rather than to support and repair the damaged organs.
authors.affiliation: Emergency Department, the Third Hospital Affiliated to Suzhou University, Changzhou 213003, Jiangsu, China.
authors.forename: Da-ming
authors.initials: DM
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.forename: Liang-cai
authors.initials: LC
authors.lastname: Ding
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000209:etiology; D007328:Insulin / Q000627:therapeutic use*; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D012151:Resuscitation / Q000379:methods; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications / Q000628:therapy*; D012772:Shock, Septic / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D007328:Insulin