Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists.
Sabbatini
Fabio Maria
FM
Neurosciences Center of Excellence for Drug Discovery, GlaxoSmithKline Medicines Research Center, Via A. Fleming 4, 37135 Verona, Italy. fabio.m.sabbatini@GSK.com
Di Fabio
Romano
R
Corsi
Mauro
M
Cavanni
Paolo
P
Bromidge
Steve M
SM
St-Denis
Yves
Y
D'Adamo
Lucilla
L
Contini
Stefania
S
Rinaldi
Marilisa
M
Guery
Sebastien
S
Savoia
Chiara
C
Mundi
Claudia
C
Perini
Benedetta
B
Carpenter
Andrew J
AJ
Dal Forno
Giovanna
G
Faggioni
Federico
F
Tessari
Michela
M
Pavone
Francesca
F
Di Francesco
Carla
C
Buson
Alberto
A
Mattioli
Mario
M
Perdona'
Elisabetta
E
Melotto
Sergio
S
D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D001068:Feeding and Eating Disorders / Q000188:drug therapy; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D054440:Receptors, Ghrelin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D006834:Hydrazines; D054440:Receptors, Ghrelin; C019289:carbohydrazide