title: Evaluation of spectral entropy to measure anaesthetic depth and antinociception in sevoflurane-anaesthetised Beagle dogs.
abstract: The use of spectral entropy to determine anaesthetic depth and antinociception was evaluated in sevoflurane-anaesthetised Beagle dogs. Dogs were anaesthetised at each of five multiples of their individual minimum alveolar concentrations (MAC; 0.75, 1, 1.25, 1.5 and 1.75 MAC), and response entropy (RE), state entropy (SE), RE-SE difference, burst suppression rate (BSR) and cardiorespiratory parameters were recorded before and after a painful stimulus. RE, SE and RE-SE difference did not change significantly after the stimuli. The correlation between MAC-entropy parameters was weak, but these values increased when 1.75 MAC results were excluded from the analysis. BSR was different to zero at 1.5 and 1.75 MAC. It was concluded that RE and RE-SE differences were not adequate indicators of antinociception and SE and RE were unable to detect deep planes of anaesthesia in dogs, although they both distinguished the awake and unconscious states.
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary School of Córdoba, University of Córdoba, Francisco Santisteban Hospital, Campus de Rabanales 14014, Córdoba, Spain. v92moroj@uco.es
authors.forename: Juan
authors.initials: J
authors.lastname: Morgaz
authors.forename: María del Mar
authors.initials: Mdel M
authors.lastname: Granados
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Domínguez
authors.forename: Rocío
authors.initials: R
authors.lastname: Navarrete
authors.forename: Andrés
authors.initials: A
authors.lastname: Fernández
authors.forename: Alba
authors.initials: A
authors.lastname: Galán
authors.forename: Pilar
authors.initials: P
authors.lastname: Muñoz
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Gómez-Villamandos
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D019277:Entropy; D005260:Female; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D016343:Monitoring, Intraoperative / Q000379:methods / Q000662:veterinary*; D010147:Pain Measurement / Q000379:methods / Q000662:veterinary; D011650:Pulmonary Alveoli / Q000378:metabolism; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane