Regulation of homologous recombination at telomeres in budding yeast.
Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic degradation or incomplete replication. Here, we review the mechanisms that contribute to regulating mitotic homologous recombination at telomeres and the role of these mechanisms in signalling short telomeres in the budding yeast Saccharomyces cerevisiae.
Eckert-Boulet
Nadine
N
Department of Biology, University of Copenhagen, Copenhagen N, Denmark.
Lisby
Michael
M
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D015825:Chromosomes, Fungal / Q000235:genetics; D017124:Conserved Sequence; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D020224:Expressed Sequence Tags / Q000378:metabolism; D011995:Recombination, Genetic; D004718:Saccharomycetales / Q000235:genetics* / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004271:DNA, Fungal; D004259:DNA-Directed DNA Polymerase