Accumulation of L-type bovine prions in peripheral nerve tissues.
We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.
Iwamaru
Yoshifumi
Y
National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. gan@affrc.go.jp
Imamura
Morikazu
M
Matsuura
Yuichi
Y
Masujin
Kentaro
K
Shimizu
Yoshihisa
Y
Shu
Yujing
Y
Kurachi
Megumi
M
Kasai
Kazuo
K
Murayama
Yuichi
Y
Fukuda
Shigeo
S
Onoe
Sadao
S
Hagiwara
Ken'ichi
K
Yamakawa
Yoshio
Y
Sata
Tetsutaro
T
Mohri
Shirou
S
Okada
Hiroyuki
H
Yokoyama
Takashi
T
D000818:Animals; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000209:etiology*; D010525:Peripheral Nerves / Q000378:metabolism*; D011328:Prions / Q000378:metabolism*
D011328:Prions