title: Spinal cord traction, vascular compromise, hypoxia, and metabolic derangements in the pathophysiology of tethered cord syndrome.
abstract: OBJECTIVE
  The definition of tethered cord syndrome (TCS) relies mainly on radiological criteria and clinical picture. The presence of a thickened filum terminale and a low-lying conus medullaris in symptomatic patients is indicative of TCS. The radiological definition of TCS does not take into account cases that involve a normal-lying conus medullaris exhibiting symptoms of the disease.
  
  
  METHODS
  The authors performed a MEDLINE search using the terms "tethered cord" and "pathophysiology." The search returned a total of 134 studies. The studies were further filtered to identify mostly basic research studies in animal models or studies related to the biomechanics of the filum terminale and spinal cord.
  
  
  RESULTS
  Spinal cord traction and the loss of filum terminale elasticity are the triggers that start a cascade of events occurring at the metabolic and vascular levels leading to symptoms of the disease. Traction on the caudal cord results in decreased blood flow causing metabolic derangements that culminate in motor, sensory, and urinary neurological deficits. The untethering operation restores blood flow and reverses the clinical picture in most symptomatic cases.
  
  
  CONCLUSIONS
  Although classically defined as a disease of a low-lying conus medullaris, the pathophysiology of TCS is much more complex and is dependent on a structural abnormality, with concomitant altered metabolic and vascular sequelae. Given the complex mechanisms underlying TCS, it is not surprising that the radiological criteria do not adequately address all presentations of the disease.
authors.affiliation: Division of Neurological Surgery, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
authors.forename: Aristotelis S
authors.initials: AS
authors.lastname: Filippidis
authors.forename: M Yashar
authors.initials: MY
authors.lastname: Kalani
authors.forename: Nicholas
authors.initials: N
authors.lastname: Theodore
authors.forename: Harold L
authors.initials: HL
authors.lastname: Rekate
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology; D002420:Cauda Equina / Q000503:physiopathology*; D004195:Disease Models, Animal; D004548:Elasticity / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D009436:Neural Tube Defects / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D012039:Regional Blood Flow / Q000502:physiology; D013116:Spinal Cord / Q000098:blood supply / Q000503:physiopathology* / Q000601:surgery