title: Analgesic and anti-inflammatory activities of 11-O-galloylbergenin.
abstract: OBJECTIVE
  Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use.
  
  
  METHODS
  11-O-galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.
  
  
  RESULTS
  11-O-galloylbergenin showed significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats. Similarly, 11-O-galloylbergenin exhibited significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.
  
  
  CONCLUSIONS
  11-O-galloylbergenin has demonstrated its significant potential to be further investigated for its discovery as a new lead compound for management of pain and inflammation.
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arfan
authors.forename: Hazrat
authors.initials: H
authors.lastname: Amin
authors.forename: Nematullah
authors.initials: N
authors.lastname: Khan
authors.forename: Inamullah
authors.initials: I
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saeed
authors.forename: Muhammad Azim
authors.initials: MA
authors.lastname: Khan
authors.lastname: Fazal-ur-Rehman
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D014934:Wood
chemical_list: C556377:11-O-galloylbergenin; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D010936:Plant Extracts; D005707:Gallic Acid; D002351:Carrageenan