Prognostic value of body mass index on short-term and long-term outcome after resection of esophageal cancer.
BACKGROUND
Cachexia and obesity have been suggested to be risk factors for postoperative complications. However, high body mass index (BMI) might result in a higher R0-resection rate because of the presence of more fatty tissue surrounding the tumor. The purpose of this study was to investigate whether BMI is of prognostic value with regard to short-term and long-term outcome in patients who undergo esophagectomy for cancer.


METHODS
In 556 patients who underwent esophagectomy (1991-2007), clinical and pathological outcome were compared between different BMI classes (underweight, normal weight, overweight, obesity).


RESULTS
Overall morbidity, mortality, and reoperation rate did not differ in underweight and obese patients. However, severe complications seemed to occur more often in obese patients (p = 0.06), and the risk for anastomotic leakage increased with higher BMI (12.5% in underweight patients compared with 27.6% in obese patients, p = 0.04). Histopathological assessment showed comparable pTNM stages, although an advanced pT stage was seen more often in patients with low/normal BMI (p = 0.02). A linear association between BMI and R0-resection rate was detected (p = 0.02): 60% in underweight patients compared with 81% in obese patients. However, unlike pT-stage (p < 0.001), BMI was not an independent predictor for R0 resection (p = 0.12). There was no significant difference in overall or disease-free 5-year survival between the BMI classes (p = 0.25 and p = 0.6, respectively).


CONCLUSIONS
BMI is not of prognostic value with regard to short-term and long-term outcome in patients who undergo esophagectomy for cancer and is not an independent predictor for radical R0 resection. Patients oncologically eligible for esophagectomy should not be denied surgery on the basis of their BMI class.
Grotenhuis
B A
BA
Department of Surgery, Erasmus Medical Center, Erasmus University, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. b.grotenhuis@erasmusmc.nl
Wijnhoven
B P L
BP
Hötte
G J
GJ
van der Stok
E P
EP
Tilanus
H W
HW
van Lanschot
J J B
JJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications; D011183:Postoperative Complications / Q000209:etiology; D011379:Prognosis; D013851:Thinness / Q000150:complications; D016896:Treatment Outcome