title: Manipulation of dendritic cell function by viruses.
abstract: Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread, survival and transmission. This review summarises recently published work identifying how viruses alter the expression of receptors, antiviral molecules, disrupt signalling pathways, subvert trafficking pathways and even affect DC function via interactions with second or third cell types. Different viruses such as human immunodeficiency virus (HIV) and herpes viruses may have widely divergent and even opposite effects on DC function, determined by the need for transfer to a primary target cell, replication within the DC or various immunoevasive mechanisms.
authors.affiliation: Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW 2145, Australia. tony_cunningham@wmi.usyd.edu.au
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Cunningham
authors.forename: Heather
authors.initials: H
authors.lastname: Donaghy
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Harman
authors.forename: Min
authors.initials: M
authors.lastname: Kim
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Turville
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D011991:Receptors, Virus / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000821:virology*; D053586:Virus Internalization; D014779:Virus Replication / Q000276:immunology; D014780:Viruses / Q000276:immunology*
chemical_list: D011991:Receptors, Virus