Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery?
Log-term prognosis of children suffering from high-risk neuroblastomas is characterized by a shortened event-free survival, especially if metastases remain after chemotherapy. We report the case of a 3-year-old boy afflicted with a stage 4 neuroblastoma and persistent residual lymph node metastases despite the administration of a various number of treatment modalities. The insertion of a MIBG (metaiodobenzylguanidine) single-photon emission computed tomography (SPECT)-CT and radio-guided surgery implementing a hand held gamma probe finally allowed the exact localization and resection of the suspected lymphatic tissue. As a consequence, the child has been under event-free remission for 20 months. Because study-based knowledge is missing due to the small number of affected patients, individual case reports are helpful to improve future treatment strategies.
Wachowiak
Robin
R
Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany. robin.wachowiak@medizin.uni-leipzig.de
Till
Holger
H
Metzger
Roman
R
Bierbach
Uta
U
Simon
Thorsten
T
Sattler
Bernhard
B
Aigner
Thomas
T
Sabri
Osama
O
Kluge
Regine
R
D019797:3-Iodobenzylguanidine; D002675:Child, Preschool; D018572:Disease-Free Survival; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D019797:3-Iodobenzylguanidine