Increased levels of 8-hydroxydeoxyguanosine in the vitreous of patients with diabetic retinopathy.
We determined the intravitreous level of 8-hydroxydeoxyguanosine (8-OHdG) in diabetic retinopathy (DR) and analyzed the relation between oxidative stress and DR. Vitreous 8-OHdG concentration increased significantly in 18 patients (20 eyes) with DR compared with controls with macular disease. This result suggests that increased oxidative stress is involved in DR.
Wakabayashi
Yoshihiro
Y
Department of Ophthalmology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. wbaki@tokyo-med.ac.jp
Usui
Yoshihiko
Y
Shibauchi
Yusuke
Y
Uchino
Hiroyuki
H
Goto
Hiroshi
H
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism
D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine