Escape from X inactivation in mice and humans.
A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment.
Berletch
Joel B
JB
Department of Pathology, University of Washington, Seattle, Washington 98195, USA.
Yang
Fan
F
Disteche
Christine M
CM
D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D004194:Disease / Q000235:genetics; D018392:Genomic Imprinting / Q000235:genetics; D006801:Humans; D008540:Meiosis / Q000235:genetics; D051379:Mice; D012730:Sex Chromosomes / Q000235:genetics; D049951:X Chromosome Inactivation / Q000235:genetics*