Comparative characterization of mesenchymal stem cells from different age groups of cynomolgus monkeys.
Bone marrow mesenchymal stem cells (BM-MSCs) are a potential tool for cell therapy and tissue engineering. In this study, we carried on a comparative study of the characteristics of MSCs from different age cynomolgus monkeys. A variety of factors, including donor age, must be considered before further applications, and various tests should be used to properly assess MSCs before the clinical application, especially when a prolonged culture and ex vivo expansion is necessary.
Ren
Zhenhua
Z
Cell Therapy Center, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, 100053, China.
Wang
Jiayin
J
Zou
Chunlin
C
Guan
Yunqian
Y
Zhang
Y Alex
YA
D000375:Aging; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D002478:Cells, Cultured; D016922:Cellular Senescence; D043171:Chromosomal Instability; D008252:Macaca fascicularis; D059630:Mesenchymal Stem Cells / Q000166:cytology*