Comparative study of cerebellar degeneration in canine neuroaxonal dystrophy, cerebellar cortical abiotrophy, and neuronal ceroid-lipofuscinosis.
The cerebellar lesions of three dogs with canine neuroaxonal dystrophy (NAD), one dog with cerebellar cortical abiotrophy (CCA), and 4 dogs with neuronal ceroid-lipofuscinosis (NCL) were examined to understand their pathogeneses. Purkinje cell loss was most severe in the vermis of a dog with CCA, and granule cell loss was most prominent in the cerebellar hemisphere of dogs with NCL. Immunohistochemically, CD3-and HLA-DR-positive cells were most frequent in the dogs with NCL, and moderate in dogs with NAD, but not in a dog with CCA. The number of cleaved caspase 3-positive cells was prominent in a dog with CCA, but no significant in the dogs with NAD. The results indicate different pathway of neuronal loss of these canine neuronal disorders.
Nibe
Kazumi
K
Division of the Project for Zoonosis Education and Research, University of Miyazaki, Miyazaki, Japan.
Nakayama
Hiroyuki
H
Uchida
Kazuyuki
K
D000818:Animals; D053148:Caspase 3 / Q000378:metabolism; D002525:Cerebellar Cortex / Q000201:enzymology / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D019150:Neuroaxonal Dystrophies / Q000201:enzymology / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D009472:Neuronal Ceroid-Lipofuscinoses / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D009919:Orchiectomy / Q000662:veterinary; D011689:Purkinje Cells / Q000473:pathology; D013132:Spinocerebellar Degenerations / Q000473:pathology / Q000662:veterinary*
D053148:Caspase 3