title: Fully automated analysis using BRAINS: AutoWorkup.
abstract: The BRAINS (Brain Research: Analysis of Images, Networks, and Systems) image analysis software has been in use, and in constant development, for over 20 years. The original neuroimage analysis pipeline using BRAINS was designed as a semiautomated procedure to measure volumes of the cerebral lobes and subcortical structures, requiring manual intervention at several stages in the process. Through use of advanced image processing algorithms the need for manual intervention at stages of image realignment, tissue sampling, and mask editing have been eliminated. In addition, inhomogeneity correction, intensity normalization, and mask cleaning routines have been added to improve the accuracy and consistency of the results. The fully automated method, AutoWorkup, is shown in this study to be more reliable (ICC ≥ 0.96, Jaccard index ≥ 0.80, and Dice index ≥ 0.89 for all tissues in all regions) than the average of 18 manual raters. On a set of 1130 good quality scans, the failure rate for correct realignment was 1.1%, and manual editing of the brain mask was required on 4% of the scans. In other tests, AutoWorkup is shown to produce measures that are reliable for data acquired across scanners, scanner vendors, and across sequences. Application of AutoWorkup for the analysis of data from the 32-site, multivendor PREDICT-HD study yield estimates of reliability to be greater than or equal to 0.90 for all tissues and regions.
authors.affiliation: The University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA 52242, USA. ronald-pierson@uiowa.edu
authors.forename: Ronald
authors.initials: R
authors.lastname: Pierson
authors.forename: Hans
authors.initials: H
authors.lastname: Johnson
authors.forename: Gregory
authors.initials: G
authors.lastname: Harris
authors.forename: Helen
authors.initials: H
authors.lastname: Keefe
authors.forename: Jane S
authors.initials: JS
authors.lastname: Paulsen
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Andreasen
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Magnotta
mesh_terms: D000465:Algorithms; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology / Q000503:physiopathology; D001331:Automation / Q000379:methods; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002649:Child Abuse; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D011237:Predictive Value of Tests; D011859:Radiography; D015203:Reproducibility of Results; D013116:Spinal Cord / Q000033:anatomy & histology / Q000502:physiology