title: [Isolation and identification of antineoplastic cyclic peptide].
abstract: OBJECTIVE
  To isolate and identify the antineoplastic constituents of the marine algae Galaxaura filamentosa.
  
  
  METHODS
  The constituents were isolated and purified by low-pressure silica gel column chromatography, thin layer chromatography and recrystallization, and their structures were elucidated by spectroscopic analysis.
  
  
  RESULTS
  Isolated a new antineoplastic cyclic peptide, cyclo-N-methyl-Leucine-Leucine-N-methyl-Leucine-Leucine-Leucine.
  
  
  CONCLUSIONS
  This new compound was remarkably active against the human renal cell carcinoma GRC-1 and human hepatocellular carcinoma HepG2 cell lines with corresponding IC50 values of 4.26 microg/mL and 4.63 microg/mL.
authors.affiliation: Department of Chemistry, Jian University, Guangzhou 510632, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Liang
authors.forename: Xiao-jian
authors.initials: XJ
authors.lastname: Liao
authors.forename: Shi-hai
authors.initials: SH
authors.lastname: Xu
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic