Joining the interface: a site for Nmd3 association on 60S ribosome subunits.
The adaptor protein Nmd3 is required for Crm1-dependent export of large ribosomal subunits from the nucleus. In this issue, Sengupta et al. (2010. J. Cell Biol. doi:10.1083/jcb.201001124) identify a binding site for yeast Nmd3 on 60S ribosomal subunits using cryoelectron microscopy and suggest a conformational model for its release in the cytoplasm. The study provides the first detailed structural description of a ribosome biogenesis factor in complex with the large subunit.
Oeffinger
Marlene
M
Laboratoire de Biochimie des ribonucléoprotéines, Institut de recherches cliniques de Montréal, Montréal, Québec H2W 1R7, Canada. marlene.oeffinger@ircm.qc.ca
D001665:Binding Sites; D002467:Cell Nucleus; D020285:Cryoelectron Microscopy; D005656:Fungal Proteins / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D054683:Ribosome Subunits, Large, Eukaryotic / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D005656:Fungal Proteins; C117894:NMD3 protein, S cerevisiae; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins