[Low levels of serotonin in serum correlates with severity of fibromyalgia].
OBJECTIVE
Fibromyalgia (FM) is a chronic pain syndrome of unknown etiology, which affects predominantly women. Among the alterations that have been implicated in the pathophysiology of FM, there have been postulated disturbances in serotonin levels and metabolism, and their implication in symptoms. The aim of the present study was to assess the correlation levels between low levels of serotonin and severity of symptoms in FM.


METHODS
We determined serotonin levels using an ELISA kit in serum from 38 FM patients and 25 healthy individual. Results were correlated with symptoms regarding pain, depression, impact of disease (FIQ) and age.


RESULTS
Serotonin levels were decreased by 45% compared to healthy individual. An important correlation was observed between serotonin levels and predetermined parameters of pain, depression, FIQ and age.


CONCLUSIONS
Serotonin levels are correlated with severity of FM. In addition, there is an interesting correlation between serotonin levels and age of patients.
Cordero
Mario David
MD
Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC y Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Sevilla, España. mdcormor@upo.es
Alcocer-Gómez
Elísabet
E
Cano-García
Francisco Javier
FJ
de Miguel
Manuel
M
Sánchez-Alcázar
Jose Antonio
JA
Moreno Fernández
Ana María
AM
D000328:Adult; D000375:Aging / Q000378:metabolism; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012701:Serotonin / Q000097:blood / Q000172:deficiency*; D012720:Severity of Illness Index
D012701:Serotonin