In the swim of things: recent insights to neurogenetic disorders from zebrafish.
The advantage of zebrafish as a model to study human pathologies lies in the ease of manipulating gene expression in vivo. Here we focus on recent progress in our understanding of motor neuron diseases and neurodevelopmental disorders and discuss how novel technologies will permit further disease models to be developed. Together these advances set the stage for this simple functional model, with particular advantages for transgenesis, multigenic analyses and chemical biology, to become uniquely suited for advancing the functional genomics of neurological and possibly psychiatric diseases - from understanding the genetics and cell biology of degenerative and developmental disorders to the discovery of therapeutics.
Kabashi
Edor
E
Center for Excellence in Neuromics, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, Université de Montréal, Montréal, QC, Canada.
Champagne
Nathalie
N
Brustein
Edna
E
Drapeau
Pierre
P
D000818:Animals; D002493:Central Nervous System Diseases / Q000235:genetics / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000503:physiopathology; D013550:Swimming; D015027:Zebrafish / Q000002:abnormalities* / Q000235:genetics*