[Correlation between sleep apnea hypopnea syndrome and preeclampsia and the possible pathogenesis of preeclampsia].
OBJECTIVE
To investigate the relationship between sleep apnea-hypopnea syndrome (SAHS) and preeclampsia and the possible pathogenesis of the latter.


METHODS
Twenty-five healthy pregnant women, 43 pregnant women with preeclampsia, and 27 with preeclampsia complicated by SAHS were enrolled in this study. Apnea-hypopnea index (AHI) and the lowest arterial oxygen saturation (LSaO2) were measured through a 7-hour polysomnography (PSG), and the maternal age, gestational age, body mass index and 24-hour urine protein were recorded.


RESULTS
All the indexes except for the maternal age and gestational age showed significant differences between the 3 groups. The two groups of preeclampsia patients showed a significant difference in BMI from the control cases. Significant positive correlations of AHI to BMI, MAP and 24-hour urine protein were noted; LSaO2 was found to inversely correlate to BMI, MAP, and 24-hour urine protein. In spite of the significant correlation of BMI to the other indexes, we found that BMI was less important than AHI and LSaO2.


CONCLUSIONS
SAHS may induce or aggravate preeclampsia. Greater attention should be given to the presence of SAHS in pregnant women with obesity, but obesity is not the predominant predisposing factor for preeclampsia.
Ye
Hong
H
Department of Sleep Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yehong20078328@126.com
Li
Tao-ping
TP
Wang
Pei
P
Xu
Zhong
Z
Chen
Dun-jin
DJ
Liu
Hui-shu
HS
Gao
Chun-huan
CH
Liu
Ai-hua
AH
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D017286:Polysomnography; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology*; D011247:Pregnancy; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012913:Snoring / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha