title: An alternative scheme for the multiplexed acquisition of 1D and 2D NMR spectra.
abstract: Spin system selective 1D (1)H, 2D DQF-COSY and 2D HSQC NMR spectra were recorded in order to fully assign the (1)H and (13)C 1D NMR spectra of an asymmetrical beta-cyclodextrin derivative. Instead of individually accessing the seven sugar anomeric protons by means of long multiplet selective pulses, only short region selective pulses were used. The simultaneously selected anomeric protons were differentiated by allowing their magnetization to evolve under the sole effect of the chemical shift interaction. In each experiment, the seven recorded spectra were linear combinations of the seven desired ones. The combination coefficients were measured and used to obtain almost perfectly separated sugar unit sub-spectra. This multiplexed acquisition scheme resulted in a time gain factor of about 2.
authors.affiliation: Institut de Chimie Moléculaire de Reims, Université de Reims Champagne-Ardenne, CNRS UMR 6229, BP 1039, F-51687 Reims Cedex 2, France.
authors.forename: B
authors.initials: B
authors.lastname: Plainchont
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.forename: S
authors.initials: S
authors.lastname: Tisse
authors.forename: J-P
authors.initials: JP
authors.lastname: Bouillon
authors.forename: J-M
authors.initials: JM
authors.lastname: Wieruszeski
authors.forename: G
authors.initials: G
authors.lastname: Lippens
authors.forename: D
authors.initials: D
authors.lastname: Jeannerat
authors.forename: J-M
authors.initials: JM
authors.lastname: Nuzillard
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D011522:Protons; D047392:beta-Cyclodextrins