title: The effect of myopia on retinal nerve fibre layer measurement: a comparative study of spectral-domain optical coherence tomography and scanning laser polarimetry.
abstract: OBJECTIVE
  To evaluate the effect of myopia on retinal nerve fibre layer (RNFL) thickness measurement by using spectral domain optical coherence tomography (Cirrus HD OCT) and scanning laser polarimetry with enhanced corneal compensator (GDx ECC).
  
  
  METHODS
  One hundred and forty-nine eyes of 149 myopic subjects were recruited and subdivided into three groups according to their refractive errors: high myopia group (spherical equivalent (SE) ≤ -6 D); moderate group (-3 D ≥ SE > -6 D); low group (-0.5D ≥ SE > - 3 D). RNFL thickness was measured by Cirrus High Definition (HD) OCT and GDx ECC. Associations between RNFL thickness and axial length/SE were evaluated by using Pearson correlation analysis.
  
  
  RESULTS
  Average RNFL thickness measured with Cirrus OCT correlated significantly with axial length (r = -0.322, p < 0.001) and SE (r = 0.291, p < 0.001). No significant correlation was detected between axial length (r = -0.068, p = 0.407)/SE (r = 0.109, p = 0.187) and RNFL thickness measured with GDx ECC.
  
  
  CONCLUSIONS
  Average RNFL thickness measured with Cirrus HD OCT decreases as the degree of myopia increases while no such correlation was detected in GDx ECC. Histological studies are warranted to further our understanding of the relationship between RNFL thickness and myopia.
authors.affiliation: Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong Province, The People's Republic of China. mingzhi_z@hotmail.com
authors.forename: Geng
authors.initials: G
authors.lastname: Wang
authors.forename: Kun Liang
authors.initials: KL
authors.lastname: Qiu
authors.forename: Xie Hui
authors.initials: XH
authors.lastname: Lu
authors.forename: Li Xia
authors.initials: LX
authors.lastname: Sun
authors.forename: Xu Jian
authors.initials: XJ
authors.lastname: Liao
authors.forename: Hong Ling
authors.initials: HL
authors.lastname: Chen
authors.forename: Ming Zhi
authors.initials: MZ
authors.lastname: Zhang
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000473:pathology* / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology* / Q000502:physiology; D012160:Retina / Q000473:pathology* / Q000503:physiopathology; D012189:Retrospective Studies; D057109:Scanning Laser Polarimetry; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult