title: Novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in B-acute lymphoblastic leukemia.
abstract: Rearrangements of JAK2 are rare and have been described in various hematological neoplasms. We report a novel JAK2 rearrangement resulting from a t(9;22)(p24;q11.2) in a 14-year-old male with a diagnosis of B lymphoblastic leukemia. He was treated with Children's Oncology Group's protocol (AALL0232) but failed to achieve remission by day 29. He underwent a second induction and entered remission. His clinical course suggested that this JAK2 rearrangement might portend an unfavorable prognosis. This case brings the total number of JAK2 rearranged lymphoblastic leukemia cases in the literature to seven. The molecular genetic and clinicopathologic features of these cases were reviewed.
authors.affiliation: Department of Pathology, Clinical Cytogenetics, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USA. carlos1.tirado@utsouthwestern.edu
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Tirado
authors.forename: Weina
authors.initials: W
authors.lastname: Chen
authors.forename: Lily Jun-shen
authors.initials: LJ
authors.lastname: Huang
authors.forename: Carrie
authors.initials: C
authors.lastname: Laborde
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Hiemenz
authors.forename: Federico
authors.initials: F
authors.lastname: Valdez
authors.forename: Kevin
authors.initials: K
authors.lastname: Ho
authors.forename: Naomi
authors.initials: N
authors.lastname: Winick
authors.forename: Zhenjun
authors.initials: Z
authors.lastname: Lou
authors.forename: Prasad
authors.initials: P
authors.lastname: Koduru
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D015448:Leukemia, B-Cell / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2