Pandemic (H1N1) 2009 influenza in the UK: clinical and epidemiological findings from the first few hundred (FF100) cases.
The UK was one of few European countries to document a substantial wave of pandemic (H1N1) 2009 influenza in summer 2009. The First Few Hundred (FF100) project ran from April-June 2009 gathering information on early laboratory-confirmed cases across the UK. In total, 392 confirmed cases were followed up. Children were predominantly affected (median age 15 years, IQR 10-27). Symptoms were mild and similar to seasonal influenza, with the exception of diarrhoea, which was reported by 27%. Eleven per cent of all cases had an underlying medical condition, similar to the general population. The majority (92%) were treated with antiviral drugs with 12% reporting adverse effects, mainly nausea and other gastrointestinal complaints. Duration of illness was significantly shorter when antivirals were given within 48 h of onset (median 5 vs. 9 days, P=0.01). No patients died, although 14 were hospitalized, of whom three required mechanical ventilation. The FF100 identified key clinical and epidemiological characteristics of infection with this novel virus in near real-time.
McLean
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Health Protection Agency, Centre for Infections, London, UK.
Pebody
R G
RG
Campbell
C
C
Chamberland
M
M
Hawkins
C
C
Nguyen-Van-Tam
J S
JS
Oliver
I
I
Smith
G E
GE
Ihekweazu
C
C
Bracebridge
S
S
Maguire
H
H
Harris
R
R
Kafatos
G
G
White
P J
PJ
Wynne-Evans
E
E
Green
J
J
Myers
R
R
Underwood
A
A
Dallman
T
T
Wreghitt
T
T
Zambon
M
M
Ellis
J
J
Phin
N
N
Smyth
B
B
McMenamin
J
J
Watson
J M
JM
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D012307:Risk Factors; D012727:Sex Characteristics; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
D000998:Antiviral Agents; D053139:Oseltamivir