title: Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
abstract: In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.
authors.affiliation: Max Planck Institute of Psychiatry, 80804 Munich, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Nischwitz
authors.forename: Sabine
authors.initials: S
authors.lastname: Cepok
authors.forename: Antje
authors.initials: A
authors.lastname: Kroner
authors.forename: Christiane
authors.initials: C
authors.lastname: Wolf
authors.forename: Matthias
authors.initials: M
authors.lastname: Knop
authors.forename: Felix
authors.initials: F
authors.lastname: Müller-Sarnowski
authors.forename: Hildegard
authors.initials: H
authors.lastname: Pfister
authors.forename: Darina
authors.initials: D
authors.lastname: Roeske
authors.forename: Peter
authors.initials: P
authors.lastname: Rieckmann
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.forename: Marcus
authors.initials: M
authors.lastname: Ising
authors.forename: Manfred
authors.initials: M
authors.lastname: Uhr
authors.forename: Thomas
authors.initials: T
authors.lastname: Bettecken
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Frank
authors.initials: F
authors.lastname: Weber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051567:Proto-Oncogene Proteins c-vav / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D055815:Young Adult; D016335:Zinc Fingers / Q000235:genetics* / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D051567:Proto-Oncogene Proteins c-vav; D012097:Repressor Proteins; C093651:VAV2 protein, human; C552877:ZNF433 protein, human