De novo synthesis and lectin binding studies of unsaturated carba-pyranoses.
Starting from branched para-benzoquinones a practical and highly flexible route is described for the preparation of unsaturated carbapyranoses. The potential of the synthesized galactose analogues to act as competitive inhibitors in lectin-carbohydrate interactions is investigated by means of Surface Plasmon Resonance (SPR) Spectroscopy.
Leermann
Timo
T
Bergische University Wuppertal, Gaussstrasse 20, 42097, Wuppertal, Germany. timo.leermann@broteleermann.de
Block
Oliver
O
Podeschwa
Michael A L
MA
Pfüller
Uwe
U
Altenbach
Hans-Josef
HJ
D054329:Carbasugars / Q000138:chemical synthesis / Q000737:chemistry*; D037102:Lectins / Q000737:chemistry*; D015394:Molecular Structure
D054329:Carbasugars; D037102:Lectins