title: Improved breath alcohol analysis in patients with depressed consciousness.
abstract: Many patients in pre-hospital and emergency care are under the influence of alcohol. In addition, some of the more common pathological conditions can introduce a behaviour that can be mistaken to be related to alcohol inebriation. Fast quantitative determination of the breath alcohol concentration (BrAC) in emergency patients facilitates triage and medical assessment, but shallow expirations performed by non-cooperative patients reduce the measurement reliability. The aim of this study was to evaluate if breath alcohol analysis in non-cooperative patients can be improved with use of simultaneous measurement of the expired carbon dioxide (CO(2)). With prototypes of a handheld breath alcohol analyser based on infrared transmission spectroscopy the alcohol and CO(2) concentration in expired breath from 37 cooperative and non-cooperative patients were measured. The results show that enhanced breath sampling with use of a pump and estimation of the end expiratory BrAC with use of the ratio between the measured partial pressure of CO(2) (PCO2) and a reference value of the alveolar PCO2, provided adequate correlation with the blood alcohol concentration (BAC). This pre-clinical study has shown that breath alcohol analysis in shallow expirations from non-cooperative patients can be improved with use of CO(2) as a tracer gas.
authors.affiliation: Hök Instrument AB, Västerås, Sweden. annika@hokinstrument.se
authors.forename: Annika
authors.initials: A
authors.lastname: Kaisdotter Andersson
authors.forename: Bertil
authors.initials: B
authors.lastname: Hök
authors.forename: Daniel
authors.initials: D
authors.lastname: Rentsch
authors.forename: Gernot
authors.initials: G
authors.lastname: Ruecker
authors.forename: Mikael
authors.initials: M
authors.lastname: Ekström
mesh_terms: D000435:Alcoholic Intoxication / Q000175:diagnosis*; D000465:Algorithms; D001944:Breath Tests / Q000295:instrumentation / Q000379:methods*; D002245:Carbon Dioxide / Q000032:analysis*; D004638:Emergency Treatment; D004867:Equipment Design; D000431:Ethanol / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D010313:Partial Pressure; D014474:Unconsciousness
chemical_list: D002245:Carbon Dioxide; D000431:Ethanol