title: Asymmetric synthesis of sphinganine and ent-clavaminol [corrected] H.
abstract: An efficient enantioselective synthesis of sphinganine and ent-clavaminol [corrected] H is reported. These sphingoid-type bases were obtained from commercially available fatty acids using highly enantioselective Ru-catalyzed hydrogenation and organocatalytic electrophilic amination reactions to create the stereogenic centers.
authors.affiliation: Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles-St-Quentin-en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
authors.forename: Ramzi
authors.initials: R
authors.lastname: Ait-Youcef
authors.forename: Xavier
authors.initials: X
authors.lastname: Moreau
authors.forename: Christine
authors.initials: C
authors.lastname: Greck
mesh_terms: D002384:Catalysis; D002518:Ceramides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D002518:Ceramides; C553735:clavaminol H; D013110:Sphingosine; C005682:safingol