Primary aldosteronism and its impact on the generation of arterial hypertension, endothelial injury and oxidative stress.
Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation/vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA.
Martinez-Aguayo
Alejandro
A
Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Carvajal
Cristian A
CA
Campino
Carmen
C
Aglony
Marlene
M
Bolte
Lillian
L
Garcia
Hernán
H
Fardella
Carlos E
CE
D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D018384:Oxidative Stress