Versatility in the acquisition of energy and carbon sources by the Apicomplexa.
Members of the phylum Apicomplexa are motile and rapidly dividing intracellular parasites, able to occupy a large spectrum of niches by infecting diverse hosts and invading various cell types. As obligate intracellular parasites, most apicomplexans only survive for a short period extracellularly, and, during this time, have a high energy demand to power gliding motility and invasion into new host cells. Similarly, these fast-replicating intracellular parasites are critically dependent on host-cell nutrients as energy and carbon sources, noticeably for the extensive membrane biogenesis imposed during growth and division. To access host-cell metabolites, the apicomplexans Toxoplasma gondii and Plasmodium falciparum have evolved strategies that exquisitely reflect adaptation to their respective niches. In the present review, we summarize and compare some recent findings regarding the energetic metabolism and carbon sources used by these two genetically tractable apicomplexans during host-cell invasion and intracellular growth and replication.
Polonais
Valerie
V
Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Valerie.Polonais@unige.ch
Soldati-Favre
Dominique
D
D000818:Animals; D002244:Carbon / Q000378:metabolism; D004734:Energy Metabolism; D004912:Erythrocytes / Q000469:parasitology; D006790:Host-Parasite Interactions; D006801:Humans; D008055:Lipids / Q000096:biosynthesis; D053858:Metabolic Networks and Pathways; D010963:Plasmodium falciparum / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism; D014122:Toxoplasma / Q000378:metabolism*
D008055:Lipids; D015800:Protozoan Proteins; D002244:Carbon