title: Mortality patterns among Paducah Gaseous Diffusion Plant workers.
abstract: OBJECTIVE
  To determine whether Paducah Gaseous Diffusion Plant workers had mortality patterns that differed from the general US population and to investigate whether mortality patterns were associated with job title or workplace exposures.
  
  
  METHODS
  A retrospective occupational cohort mortality study was conducted on 6759 workers. Standardized mortality ratio analyses compared the cohort with the referent US population. Internal comparisons producing standardized rate ratios were conducted by job title, metal exposure, and cumulative internal and external radiation exposures.
  
  
  RESULTS
  Overall mortality and cancer rates were lower than the referent population, reflecting a strong healthy worker effect. Individual not significant standardized mortality ratios and standardized rate ratios were noted for cancers of the lymphatic and hematopoietic tissue.
  
  
  CONCLUSIONS
  Although relatively low exposures to radiation and metals did not produce statistically significant health effects, no significant elevations for lymphatic and hematopoietic cancers were consistent with previous studies of nuclear workers.
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, USA. caroline.chan@louisville.edu
authors.forename: Caroline
authors.initials: C
authors.lastname: Chan
authors.forename: Therese S
authors.initials: TS
authors.lastname: Hughes
authors.forename: Susan
authors.initials: S
authors.lastname: Muldoon
authors.forename: Tim
authors.initials: T
authors.lastname: Aldrich
authors.forename: Carol
authors.initials: C
authors.lastname: Rice
authors.forename: Richard
authors.initials: R
authors.lastname: Hornung
authors.forename: Gail
authors.initials: G
authors.lastname: Brion
authors.forename: David J
authors.initials: DJ
authors.lastname: Tollerud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005459:Fluorides / Q000633:toxicity*; D006801:Humans; D007629:Kentucky / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000145:classification / Q000401:mortality; D055848:Nuclear Power Plants / Q000706:statistics & numerical data*; D009688:Nuclear Reactors / Q000706:statistics & numerical data; D009784:Occupational Diseases / Q000145:classification / Q000401:mortality*; D016273:Occupational Exposure; D012189:Retrospective Studies; D017974:Uranium Compounds / Q000633:toxicity*; D055815:Young Adult
chemical_list: D017974:Uranium Compounds; C036638:uranium hexafluoride; D005459:Fluorides