Integrative genomic profiling of human prostate cancer.
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.
Taylor
Barry S
BS
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Schultz
Nikolaus
N
Hieronymus
Haley
H
Gopalan
Anuradha
A
Xiao
Yonghong
Y
Carver
Brett S
BS
Arora
Vivek K
VK
Kaushik
Poorvi
P
Cerami
Ethan
E
Reva
Boris
B
Antipin
Yevgeniy
Y
Mitsiades
Nicholas
N
Landers
Thomas
T
Dolgalev
Igor
I
Major
John E
JE
Wilson
Manda
M
Socci
Nicholas D
ND
Lash
Alex E
AE
Heguy
Adriana
A
Eastham
James A
JA
Scher
Howard I
HI
Reuter
Victor E
VE
Scardino
Peter T
PT
Sander
Chris
C
Sawyers
Charles L
CL
Gerald
William L
WL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D055028:Comparative Genomic Hybridization; D018628:Gene Dosage; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020411:Oligonucleotide Array Sequence Analysis; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; C515553:TMPRSS2-ERG fusion protein, human