[Sheshiliuhuang decoction on cytokines in patients with urinary tract infection].
OBJECTIVE
To investigate the therapeutic effects of Sheshiliuhuang decoction on clinical outcomes and cytokines in patients with urinary tract infection (UTI).


METHODS
Ninety-two (92) patients were selected and randomly divided into 2 groups, the treatment group (n = 47) administered with Sheshiliuhuang decoction, one prescription, 2 times a day, while patients in the control group (n = 45) were given Sanjin pills, 3 pills a time, 3 times a day. The treatment lasted for 7 days. Clinical outcomes and serum levels of TNF-alpha, IL-6, IL-8 in both groups were examined before and after the treatment.


RESULTS
The clinical effective rate was 93.62% in the treatment group and 88.22% the control group, indicating a significant difference of P < 0.05. Before the treatment, the serum levels of TNF-alpha, IL-6, IL-8 of treatment group were significantly higher than those in the control group (P < 0.05). At the end of the treatment, serum levels of IL-6 and TNF-alpha in the treatment group were significantly decreased compared with the before treatment (P < 0.01) and those did in the control group (P < 0.01).


CONCLUSIONS
Serum cytokines of IL-6, IL-8, and TNF-alpha were significantly increased in patients with UTI. Sheshiliuhuang decoction, with the mechanisms of regulating IL-6, IL-8, TNF-alpha, is an effective agent in patients with UTI.
Ding
Fan
F
Hulunbuir Ctiy Hailar District Infectious Diseases Hospital, Hailar 021000, China.
Zhang
Yanchun
Y
Chang
Yijie
Y
D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000378:metabolism* / Q000628:therapy; D055815:Young Adult
D016207:Cytokines