title: Cellular proliferation in female pelvic organ prolapse: a pilot study.
abstract: OBJECTIVE
  To assess cell proliferation in pelvic organ prolapse (POP).
  
  
  METHODS
  Tissue samples of the anterior vaginal wall and uterosacral ligaments (USLs) were obtained from eight women with combined anterior vaginal wall and uterine prolapse and from eight women without POP in a standardized fashion. Immunohistochemistry against Ki-67 was used to assess cell proliferation in vaginal and USL biopsies.
  
  
  RESULTS
  There were no significant differences in age, parity, menopausal status or hormone replacement therapy between the two groups. The POP-Q stage of uterine and anterior vaginal wall prolapse was significantly higher in the group of women with prolapse compared to the group without prolapse [median (range) 3 (3-4) vs. 0 (0), <0.01]. There was no significant difference between Ki-67 expressions in women with or without prolapse.
  
  
  CONCLUSIONS
  There were no significant differences in cell proliferation between samples from women with or without POP.
authors.affiliation: Department of Obstetrics and Gynecology (D-50), Jackson Memorial Hospital, Miller School of Medicine, University of Miami, PO Box 016960, Miami, FL 33010, USA. ptakacs@med.miami.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Takacs
authors.forename: Cristina
authors.initials: C
authors.lastname: Saiz
authors.forename: Sindy
authors.initials: S
authors.lastname: Jaramillo
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Sujata
authors.initials: S
authors.lastname: Yavagal
authors.forename: Keith
authors.initials: K
authors.lastname: Candiotti
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Medina
mesh_terms: D001706:Biopsy; D049109:Cell Proliferation; D052858:Cystocele / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000032:analysis*; D008022:Ligaments / Q000473:pathology; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D010865:Pilot Projects; D012016:Reference Values; D014596:Uterine Prolapse / Q000473:pathology*; D014621:Vagina / Q000473:pathology
chemical_list: D019394:Ki-67 Antigen