Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight.
Eucommia ulmoides Oliver leaf extracts (ELE) have been shown to exert a hypolipidemic effect in hamsters. Therefore, it was hypothesized that ELE might affect lipid metabolism via changes in autonomic nerve activities and causes changes in thermogenesis and body weight. We examined this hypothesis, and found that intraduodenal (ID) injection of ELE elevated epididymal white adipose tissue sympathetic nerve activity (WAT-SNA) and interscapular brown adipose tissue sympathetic nerve activity (BAT-SNA) in urethane-anesthetized rats and elevated the plasma concentration of free fatty acids (FFA) (a marker of lipolysis) and body temperature (BT) (a marker of thermogenesis) in conscious rats. Furthermore, it was observed that ID administration of ELE decreased gastric vagal nerve activity (GVNA) in urethane-anesthetized rats, and that ELE given as food reduced food intake, body and abdominal adipose tissue weights and decreased plasma triglyceride level. These findings suggest that ELE stimulates lipolysis and thermogenesis through elevations in WAT-SNA and BAT-SNA, respectively, suppresses appetite by inhibiting the activities of the parasympathetic nerves innervating the gastrointestinal tract, including GVNA, and decreases the amount of abdominal fat and body weight via these changes.
Horii
Yuko
Y
ANBAS Corporation, 4-12-17 Toyosaki, Kita-Ku, Osaka 531-0072, Japan. yhorii@anbas.co.jp
Tanida
Mamoru
M
Shen
Jiao
J
Hirata
Tetsuya
T
Kawamura
Naomi
N
Wada
Atsunori
A
Nagai
Katsuya
K
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000294:innervation; D052436:Adipose Tissue, White / Q000187:drug effects / Q000294:innervation; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D031283:Eucommiaceae; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000294:innervation; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D010936:Plant Extracts