title: A new anxiolytic fatty acid from Aethusa cynapium.
abstract: The present investigation was carried out with a view to separate bioactive constituent from Aethusa cynapium. Bioactivity guided fractionation of the anxiolytic methanol extract has led to the isolation of a novel unsaturated fatty acid. Structure of the acid characterized by UV, IR, 1H NMR, C13 NMR, MS techniques was found to be trideca-7, 9, 11-trienoic acid. Antianxiety activity was confirmed using the mCPP-induced hypolocomotion test. This new fatty acid-trideca-7,9,11-trienoic acid, isolated from A. cynapium was found to be responsible for the antianxiety activity of the plant.
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Panjab, India.
authors.forename: Richa
authors.initials: R
authors.lastname: Shri
authors.forename: K K
authors.initials: KK
authors.lastname: Bhutani
authors.forename: Anupam
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy; D019661:Apiaceae / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D035261:Plant Components, Aerial
chemical_list: D005227:Fatty Acids