title: Relationship of adiponectin and resistin levels in umbilical and maternal serum with fetal macrosomia.
abstract: OBJECTIVE
  Adiponectin and resistin are novel hormones secreted by human adipocytes and mononuclear cells, which have been postulated to play roles in the regulation of energy metabolism during pregnancy. However, correlations between adiponectin and resistin levels in umbilical and maternal serum and fetal macrosomia remain poorly understood. The purpose of this study was to clarify the relationship of adiponectin and resistin levels in umbilical and maternal serum with fetal macrosomia.
  
  
  METHODS
  Serum adiponectin and resistin levels were prospectively measured by enzyme immunoassay in 70 mothers and their 70 neonates. The study group included 30 neonates with macrosomia and the control group included 40 neonates that were appropriate for gestational age. The correlations of cord serum adiponectin and resistin with maternal serum adiponectin and resistin, birth weight, body mass index (BMI), and placental weight were analyzed.
  
  
  RESULTS
  Serum adiponectin and resistin levels were significantly decreased in macrosomic mothers compared with those in control women. The levels of adiponectin and resistin were diminished in macrosomic babies in comparison with control newborns. Umbilical serum adiponectin levels were inversely correlated with birth weight, newborn BMI, and placental weight, but not with maternal serum adiponectin levels. Umbilical serum resistin levels had a positive correlation with maternal serum resistin and a negative correlation with birth weight, newborn BMI, and placental weight. In addition, maternal serum resistin levels were inversely correlated with newborn birth weight.
  
  
  CONCLUSIONS
  It is suggested that adiponectin and resistin play important roles in controlling body weight and may be related to the occurrence of fetal macrosomia.
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shu-He
authors.initials: SH
authors.lastname: Wang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Shang
authors.forename: Xing
authors.initials: X
authors.lastname: Dong
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Xu
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Ye
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015992:Body Mass Index; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005320:Fetal Macrosomia / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D052243:Resistin