title: Zygomycotic invasion of the central nervous system.
abstract: Zygomycosis is an opportunistic fungal infection that affects the central nervous system (CNS). In this report, we present three cases of zygomycosis with CNS involvement. In two patients zygomycosis developed after neurosurgery, and in the third patient zygomycosis developed after bone marrow transplantation for leukemia. All patients developed persistent fever and neurological deficits. They presented with progressive cerebral infarction accompanied by hemorrhage. Intraoperative findings and histopathological examinations revealed that zygomycotic hyphae caused mycotic aneurysm, vasculitis, and venous occlusion.
authors.affiliation: Department of Radiology, Asahikawa Red Cross Hospital, Akebono, Asahikawa, Japan. tomoaki3est@gmail.com
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mineta
authors.forename: Keigo
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ando
authors.forename: Masahiko
authors.initials: M
authors.lastname: Obata
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D002544:Cerebral Infarction / Q000209:etiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D019635:Neurosurgical Procedures; D009894:Opportunistic Infections; D011183:Postoperative Complications; D011859:Radiography; D020096:Zygomycosis / Q000000981:diagnostic imaging / Q000209:etiology*