title: Design of cellular porous biomaterials for wall shear stress criterion.
abstract: The microfluidic environment provided by implanted prostheses has a decisive influence on the viability, proliferation and differentiation of cells. In bone tissue engineering, for instance, experiments have confirmed that a certain level of wall shear stress (WSS) is more advantageous to osteoblastic differentiation. This paper proposes a level-set-based topology optimization method to regulate fluidic WSS distribution for design of cellular biomaterials. The topological boundary of fluid phase is represented by a level-set model embedded in a higher-dimensional scalar function. WSS is determined by the computational fluid dynamics analysis in the scale of cellular base cells. To achieve a uniform WSS distribution at the solid-fluid interface, the difference between local and target WSS is taken as the design criterion, which determines the speed of the boundary evolution in the level-set model. The examples demonstrate the effectiveness of the presented method and exhibit a considerable potential in the design optimization and fabrication of new prosthetic cellular materials for bioengineering applications.
authors.affiliation: School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, NSW 2006, Australia.
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Chen
authors.forename: Shiwei
authors.initials: S
authors.lastname: Zhou
authors.forename: Joseph
authors.initials: J
authors.lastname: Cadman
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials; D049109:Cell Proliferation; D006801:Humans; D044085:Microfluidics; D010011:Osteocytes / Q000502:physiology*; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials