title: Chronic consumption of fructose rich soft drinks alters tissue lipids of rats.
abstract: BACKGROUND
  Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink.
  
  
  METHODS
  Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks.
  
  
  RESULTS
  The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls.
  
  
  CONCLUSIONS
  Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.
authors.affiliation: São Paulo State University - UNESP, Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, Rio Claro - São Paulo- Brazil. jdbotezelli@yahoo.com.br.
authors.forename: Jose D
authors.initials: JD
authors.lastname: Botezelli
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Dalia
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Reis
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Barbieri
authors.forename: Tiago M
authors.initials: TM
authors.lastname: Rezende
authors.forename: Jailton G
authors.initials: JG
authors.lastname: Pelarigo
authors.forename: Jamile
authors.initials: J
authors.lastname: Codogno
authors.forename: Raquel
authors.initials: R
authors.lastname: Gonçalves
authors.forename: Maria A
authors.initials: MA
authors.lastname: Mello