Acute megakaryocytic leukemia (AMKL,FAB;M7) with Beckwith-Wiedemann syndrome.
Beckwith-Wiedemann syndrome (BWS) is characterized by an accumulation of multiple congenital anomalies. Although patients with BWS are known to have a higher incidence of embryonal tumors, there has been no reports associated with acute leukemia. This report describes the case of a patient with BWS who developed Acute Megakaryocytic Leukemia (AMKL,FAB;M7). Because most patients with BWS present gigantism, the therapy-related toxicity of chemotherapy can be a very serious problem. This patient exhibited no therapy-related toxicity after chemotherapy, suggesting that acute leukemia with BWS may not require a reduction in dosage.
Yamamoto
Shohei
S
Division of Pediatrics, Department of Showa University Fujigaoka Hospital, Aoba-ku, Yokohama, Kanagawa, Japan. shohei-y@showa-university-fujigaoka.gr.jp
Toyama
Daisuke
D
Yatsuki
Hitomi
H
Higashimoto
Ken
K
Soejima
Hidenobu
H
Isoyama
Keiichi
K
D001506:Beckwith-Wiedemann Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology*; D008297:Male