Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.
Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in B16 mouse melanoma cells.
Koyama
Koichiro
K
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.
Hirasawa
Yusuke
Y
Hosoya
Takahiro
T
Hoe
Teh Chin
TC
Chan
Kit-Lam
KL
Morita
Hiroshi
H
D031051:Alstonia / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008968:Molecular Conformation; D014749:Vincamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C063621:apovincamine; D014749:Vincamine