title: Subcompartmentalized polymer hydrogel capsules with selectively degradable carriers and subunits.
abstract: Subcompartmentalized hydrogel capsules (SHCs) with selectively degradable carriers and subunits are designed for potential applications in drug delivery and microencapsulated biocatalysis. Thiolated poly(methacrylic acid) and poly(N-vinyl pyrrolidone) are used to assemble 3-microm-diameter carrier capsules and 300-nm-diameter subunits, independently stabilized by a diverse range of covalent linkages. This paper presents examples of SHCs with tens of subcompartments and their successful drug loading, as well as selective degradation of the SHC carrier and/or subunits in response to multiple chemical stimuli.
authors.affiliation: Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria, Australia.
authors.forename: Olga
authors.initials: O
authors.lastname: Kulygin
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Price
authors.forename: Siow-Feng
authors.initials: SF
authors.lastname: Chong
authors.forename: Brigitte
authors.initials: B
authors.lastname: Städler
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D055162:Biocatalysis; D004337:Drug Carriers; D020100:Hydrogels / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); C030613:polymethacrylic acid