title: Comparison of spectral fitting methods for overlapping J-coupled metabolite resonances.
abstract: There is increasing interest in the use of two-dimensional J-resolved spectroscopic acquisition (multiecho) methods for in vivo proton magnetic resonance spectroscopy due to the improved discrimination of overlapping J-coupled multiplet resonances that is provided. Of particular interest is the potential for discrimination of the overlapping resonances of glutamate and glutamine. In this study, a new time-domain parametric spectral model that makes use of all available data is described for fitting the complete two-dimensional multiecho data, and the performance of this method was compared with fitting of one-dimensional spectra obtained following averaging multiecho data (echo time-averaged) and single-echo time PRESS (Point Resolved Spectroscopy) acquired spectra. These methods were compared using data obtained from a phantom containing typical brain metabolites and a human brain. Results indicate that improved performance and accuracy is obtained for the two-dimensional acquisition and spectral fitting model.
authors.affiliation: Department of Radiology, University of Miami School of Medicine, Miami, Florida 33136, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gonenc
authors.forename: V
authors.initials: V
authors.lastname: Govind
authors.forename: S
authors.initials: S
authors.lastname: Sheriff
authors.forename: A A
authors.initials: AA
authors.lastname: Maudsley
mesh_terms: D000465:Algorithms; D001704:Biopolymers / Q000032:analysis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D018698:Glutamic Acid / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D011522:Protons
chemical_list: D001704:Biopolymers; D011522:Protons; D018698:Glutamic Acid