title: The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.
abstract: It was recently reported that GCKR rs780094 was associated with fasting plasma glucose (FPG) and triglyceride (TG) levels in various ethnic populations (A allele for low FPG and high TG). An association between GCKR rs780094 and type 2 diabetes mellitus (T2DM) (A allele for low risk) has also been reported. We examined the association between GCKR rs780094 and T2DM in Japanese subjects by analyzing 488 cases and 398 controls. A meta-analysis was performed involving two previous association studies. We also analyzed the association between the single-nucleotide polymorphism and clinical parameters in the general Japanese population (n=1854). In the case-control study, the A allele of GCKR rs780094 was associated with a reduced risk of T2DM (odds ratio=0.711 (95% confidence interval=0.589-0.859), P=4.2 × 10(-4)). A meta-analysis confirmed the association of GCKR rs780094 with T2DM susceptibility. In the general Japanese population, subjects with the A/A genotype had lower levels of FPG, fasting plasma insulin and homeostasis model assessment of insulin resistance than those with the G/G genotype. Conversely, subjects with the A/A genotype had higher levels of TG than those with the G/G genotype. We replicated GCKR rs780094 as a marker of T2DM susceptibility in Japanese subjects. This suggests that GCKR rs780094 is a common variant for T2DM susceptibility in various ethnic groups.
authors.affiliation: Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. onuma@m.ehime-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onuma
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Ikki
authors.initials: I
authors.lastname: Shimizu
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kawamura
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Takata
authors.forename: Wataru
authors.initials: W
authors.lastname: Nishida
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Hideichi
authors.initials: H
authors.lastname: Makino
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Osawa
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D000081410:Germinal Center Kinases; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012306:Risk; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D000081410:Germinal Center Kinases; D014280:Triglycerides; D017346:Protein Serine-Threonine Kinases