title: Accumulation of L-type bovine prions in peripheral nerve tissues.
abstract: We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.
authors.affiliation: National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. gan@affrc.go.jp
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Iwamaru
authors.forename: Morikazu
authors.initials: M
authors.lastname: Imamura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Kentaro
authors.initials: K
authors.lastname: Masujin
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yujing
authors.initials: Y
authors.lastname: Shu
authors.forename: Megumi
authors.initials: M
authors.lastname: Kurachi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kasai
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fukuda
authors.forename: Sadao
authors.initials: S
authors.lastname: Onoe
authors.forename: Ken'ichi
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Shirou
authors.initials: S
authors.lastname: Mohri
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000209:etiology*; D010525:Peripheral Nerves / Q000378:metabolism*; D011328:Prions / Q000378:metabolism*
chemical_list: D011328:Prions