SLT and adjunctive medical therapy: a prediction rule analysis.
OBJECTIVE
To investigate if specific classes of antiglaucoma medications have an influence on selective laser trabeculoplasty (SLT) success.


METHODS
This retrospective prediction rule analysis investigated 120 eyes from 120 patients diagnosed with either open angle glaucoma or ocular hypertension, who underwent SLT treatment. Treatment success was defined as ≥20% intraocular pressure (IOP) reduction at 3 and 6 months after the treatment date. Multivariate logistic regression analyses were performed to determine success predictors.


RESULTS
Pre-SLT IOP (up to 4 wk before SLT therapy) was the only independent predictor for ≥20% IOP reduction with an odds ratio of 1.30 when controlling for pre-SLT antiglaucoma drops. The area under receiver operator characteristic curve was 0.777.


CONCLUSIONS
Topical medications do not adversely, nor favorably, affect SLT success. SLT efficacy is positively associated with the degree of IOP elevation before SLT treatment. Pigmentation of the anterior chamber angle, class of antiglaucoma medications, diabetes, sex, corneal thickness, pseudophakia, diagnosis, washout of eye drops, and previous argon laser trabeculoplasty treatment are not associated with SLT treatment efficacy.
Martow
Evan
E
Department of Ophthalmology, Ivey Eye Institute, St Joseph's Hospital, Lawson Health Research Institute, University of Western Ontario, Ontario, Canada.
Hutnik
Cindy M L
CM
Mao
Alexander
A
D000287:Administration, Topical; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000068438:Brimonidine Tartrate; D017889:Exfoliation Syndrome / Q000188:drug therapy / Q000601:surgery; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy / Q000601:surgery; D010862:Pilocarpine / Q000008:administration & dosage; D011810:Quinoxalines / Q000008:administration & dosage; D012372:ROC Curve; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
D000959:Antihypertensive Agents; D011810:Quinoxalines; D010862:Pilocarpine; D000068438:Brimonidine Tartrate