Complex role of the HIF system in cardiovascular biology.
The hypoxia-inducible factor (HIF) system was discovered as an oxygen-sensitive regulatory pathway that confers adaptive responses to hypoxia. Novel aspects of this growing network indicate that there is a significant, nonhypoxic contribution to regulation. Multiple lines of evidence suggest that components of the HIF pathway are intimately involved in the pathogenesis of cardiovascular disorders. This review highlights the functional context of the HIF system in cardiovascular pathobiology with possible therapeutic implications.
Czibik
Gabor
G
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, West Wing, Level 6, Headley way, OX3 9DU, Oxford, UK. gabor.czibik@cardiov.ox.ac.uk
D000818:Animals; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism*
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D020033:Protein Isoforms; D011393:Procollagen-Proline Dioxygenase; D010100:Oxygen