title: Porphyromonas gingivalis in dental plaque and serum C-reactive protein levels in pregnancy.
abstract: BACKGROUND
  The periodontopathogen Porphyromonas gingivalis (Pg) has been reported as a risk factor for preterm labour. Its pathogenesis and role in pregnancy have not been investigated in Lebanon. Elevated C-reactive protein (CRP) levels in pregnant women with periodontitis also appear to mediate preterm labour.
  
  
  METHODS
  The study included 20 pregnant women with periodontitis and 20 with normal periodontium. PCR was done for Pg detection in oral plaque and vaginal samples. Serum CRP levels were determined by ELISA.
  
  
  RESULTS
  Pg was detected in the oral plaque of 13 of 20 pregnant subjects with clinical periodontitis (patients) and 2 of 20 controls with a healthy periodontium. Vaginal swabs were all Pg-negative, ruling out systemic infection. Serum CRP levels were elevated in 12 of 20 patients and 8 of 20 controls. None of the participants experienced preterm labour.
  
  
  CONCLUSIONS
  This is the first report that implicates Pg in Lebanese periodontitis patients. Preliminary results do not indicate a relationship among Pg, periodontitis, CRP levels and preterm labour.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon.
authors.forename: Nada M
authors.initials: NM
authors.lastname: Souccar
authors.forename: Marita
authors.initials: M
authors.lastname: Chakhtoura
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Ghafari
authors.forename: Alexander Michael
authors.initials: AM
authors.lastname: Abdelnoor
mesh_terms: D000328:Adult; D016866:Bacteroidaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D002097:C-Reactive Protein / Q000032:analysis*; D003773:Dental Plaque / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007861:Lebanon / Q000453:epidemiology; D010518:Periodontitis / Q000453:epidemiology* / Q000382:microbiology; D016133:Polymerase Chain Reaction; D016966:Porphyromonas gingivalis / Q000302:isolation & purification*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D044967:Serum / Q000737:chemistry; D014621:Vagina / Q000382:microbiology; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein