Cardioprotective effects of selenium on chromium (VI)-induced toxicity in female rats.
Acute exposure to hexavalent chromium compounds can cause cardiotoxicity. Our study pertains to the protective effect of selenium against K(2)Cr(2)O(7)-induced cardiotoxicity. Female Wistar rats were divided into four groups of six each: group I served as controls which received standard diet; group II received in drinking water K(2)Cr(2)O(7) alone (700 ppm); group III received both K(2)Cr(2)O(7) and Se (0.5 Na(2)SeO(3) mg/kg of diet); group IV received Se (0.5 mg/kg of diet) for 3 weeks. The exposure of rats to chromium promoted oxidative stress with an increase in malondialdehyde levels and a decrease in antioxidant non-enzymatic levels such as glutathione, non-protein thiol and vitamin C, while, an increase in glutathione peroxidase, superoxide dismutase and catalase activities was observed. However, plasma transaminases, lactate dehydrogenase activities, cholesterol, triglycerides and low density lipoprotein-cholesterol levels increased, and high density lipoprotein-cholesterol decreased. Coadministration of Se restored the parameters cited above to near-normal values. The histopathological findings confirmed the biochemical results.
Soudani
Nejla
N
Animal Physiology Laboratory, Life Sciences Department, UR/08-73, Sfax Faculty of Sciences, BP1171, 3000 Sfax , Tunisia.
Troudi
Afef
A
Bouaziz
Hanen
H
Ben Amara
Ibtissem
I
Boudawara
Tahia
T
Zeghal
Najiba
N
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D054715:Cardiotoxins / Q000633:toxicity*; D002857:Chromium / Q000633:toxicity*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*
D002316:Cardiotonic Agents; D054715:Cardiotoxins; D002857:Chromium; D005978:Glutathione; D012643:Selenium