title: Chemoselective reductive cross-coupling of 1,5-diene-3-ols with alkynes: a facile entry to stereodefined skipped trienes.
abstract: A convergent synthesis of highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling of substituted 1,5-diene-3-ols with alkynes. The control of site selectivity in functionalization of the substituted diene is a central feature of this complex fragment union reaction.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Diez
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Micalizio
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes