[Approaches and problems in vaccine development against leishmaniasis].
Leishmaniasis is a major public health problem of the world and Turkey. Recently there has been increasing interest in vaccine studies among strategies for control of leishmaniasis. Recently the increase of interest in vaccine studies among leishmaniasis control strategies makes the subject more up to date. So the aim of this review is to present information about recent vaccine studies, problems and new strategies for vaccine development studies. There are 3 generations of vaccine against leishmaniasis. First-generation vaccines are killed or live attenuated parasites; second-generation vaccines are recombinant or native antigens and live genetically modified parasites (knock out and suicidal cassettes), third generation vaccines are DNA vaccines. Also vector salivary proteins, dendritic cells and non-pathogenic L. tarentolae have been used as vaccine candidates. However there is still no effective vaccine against leishmaniasis. Since polymer conjugates considerably increase immunogenicity, polymer based vaccine studies have gained importance in recent years. However, there has not been such a study for an antileishmanial vaccine yet. LPG, surface antigen of Leishmania promastigotes, and polymer conjugates may be promising in antileishmanial vaccine studies so we are carrying out a TUBITAK Project on this subject which has been given the number, 1085170SBAG-4007.
Allahverdiyev
Adil
A
Yildiz Teknik Universitesi, Kimya-Metalurji Fakültesi, Biyomühendislik Bölümü, Esenler, Istanbul, Turkey. adilmoglu@gmail.com
Bağirova
Melahat
M
Cakir Koç
Rabia
R
Oztel
Olga Nehir
ON
Elçıçek
Serhat
S
Ateş
Sezen Canım
SC
Karaca
Tuğçe Deniz
TD
D014943:Global Health; D006801:Humans; D007891:Leishmania / Q000276:immunology*; D007896:Leishmaniasis / Q000517:prevention & control*; D016052:Protozoan Vaccines; D014421:Turkey; D014611:Vaccination / Q000592:standards / Q000639:trends*; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic
D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic