title: 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
abstract: BACKGROUND
  Human chromosome 8q24 has been implicated in prostate tumorigenesis.
  
  
  METHODS
  Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).
  
  
  RESULTS
  Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.
  
  
  CONCLUSIONS
  Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.
authors.affiliation: Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA.
authors.forename: Marnita L
authors.initials: ML
authors.lastname: Benford
authors.forename: Tiva T
authors.initials: TT
authors.lastname: VanCleave
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Lavender
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
authors.forename: LaCreis R
authors.initials: LR
authors.lastname: Kidd
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D005819:Genetic Markers; D004247:DNA