title: Enantioselective synthesis of highly functionalised amides by copper-catalysed vinylogous Mukaiyama aldol reaction.
abstract: Amides with quaternary stereogenic centers have been synthesised by catalytic asymmetric vinylogous Mukaiyama aldol reactions. The chiral copper-sulfoximine catalyst gives rise to products with moderate to good yields and up to 92% ee.
authors.affiliation: Institute of Organic Chemistry RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Frings
authors.forename: Daniel
authors.initials: D
authors.lastname: Goedert
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000577:Amides; D003300:Copper; C116609:3-hydroxybutanal