Coenzyme Q10: a therapy for hypertension and statin-induced myalgia?
Some small clinical trials seem to show that coenzyme Q10 supplements can be used to lower blood pressure and to treat or prevent myalgia caused by hydroxymethylglutaryl coenzyme A reductase inhibitors (statins). However, larger trials are needed to determine if they are truly effective for these purposes. The authors examine the evidence and also discuss issues such as bioavailability, elimination, safety, and cost.
Wyman
Marcia
M
Drug Information Center, Department of Pharmacy, Cleveland Clinic, Cleveland, OH 44195, USA. wymanm@ccf.org
Leonard
Mandy
M
Morledge
Thomas
T
D000959:Antihypertensive Agents / Q000627:therapeutic use; D019587:Dietary Supplements; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy*; D009135:Muscular Diseases / Q000139:chemically induced / Q000188:drug therapy*; D018570:Risk Assessment; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10