title: Acanthosis nigricans among Northern Plains American Indian children.
abstract: The purpose of this study is to present cross-sectional and prospective data on acanthosis nigricans (AN) prevalence in the context of other risk factors for diabetes including high body mass index (BMI), abnormal blood pressure (BP), physical inactivity and family history of diabetes among Northern Plains American Indian (AI) children. Standardized health measures were collected in 2,520 K-12th-grade AI students for AN, BMI, and BP. Data were also collected on family history of diabetes and physical activity. Approximately, 9.7% of the participants were positive for AN. AN was associated with high BMI, abnormal BP, and diabetes family history. Sports participation was inversely associated with AN. Among children measured the prior year, relative risk (and 95% confidence interval [CI]) for obesity and incident AN was 9.8 (4.2-23.0) compared to normal weight. These findings suggest there is utility in measuring this marker of insulin resistance in this at-risk population.
authors.affiliation: The University of Montana, Missoula, Montana, USA.
authors.forename: Blakely
authors.initials: B
authors.lastname: Brown
authors.forename: Curtis
authors.initials: C
authors.lastname: Noonan
authors.forename: Bonnie
authors.initials: B
authors.lastname: Bentley
authors.forename: Kathrene
authors.initials: K
authors.lastname: Conway
authors.forename: Mary
authors.initials: M
authors.lastname: Corcoran
authors.forename: Kris
authors.initials: K
authors.lastname: FourStar
authors.forename: Shannon
authors.initials: S
authors.lastname: Gress
authors.forename: Sharon
authors.initials: S
authors.lastname: Wagner
mesh_terms: D000052:Acanthosis Nigricans / Q000453:epidemiology*; D000293:Adolescent; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D002669:Child Welfare / Q000706:statistics & numerical data; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data*; D008297:Male; D009009:Montana / Q000453:epidemiology; D009765:Obesity; D016017:Odds Ratio; D050177:Overweight; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D014959:Wyoming / Q000453:epidemiology; D055815:Young Adult