Reactive lymphoid hyperplasia of the liver associated with primary biliary cirrhosis.
BACKGROUND
Although reactive lymphoid hyperplasia (RLH) can be found in various organs, including the gastrointestinal tract, orbit, lung, and skin, its occurrence in the liver is rare.


METHODS
We report the case of a 47-year-old RLH woman who was identified with RLH of the liver during clinical follow- up of primary biliary cirrhosis. The mass, found incidentally during a medical examination, appeared on ultrasonogram as a hypoechoic mass in the 7th segment of the liver. Further analyses using composed tomography, magnetic resonance imaging, and angiography suggested malignancy, and we performed lateral segmentectomy of the liver. Histologically, the tumor was composed of lymphoid follicles with germinal centers that expressed kappa and lambda light-chain B-cell markers at equal frequency, and no IgH gene rearrangements were detected in Southern blots. Based on these results, we identified the lesion as RLH.


CONCLUSIONS
We suggest that this diagnosis be taken into consideration in other cases involving a space-occupying liver mass associated with autoimmune disease.
Fukuo
Yuka
Y
Department of Gastroenterology Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Shibuya
Tomoyoshi
T
Fukumura
Yuki
Y
Mizui
Tomokazu
T
Sai
Jin Kan
JK
Nagahara
Akihito
A
Tsukada
Akira
A
Matsumoto
Toshiharu
T
Suyama
Masafumi
M
Watanabe
Sumio
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed