title: Polyethylene glycol hydrogel polymer sealant for closure of sutureless sclerotomies: a histologic study.
abstract: OBJECTIVE
  To evaluate a polyethylene glycol-based hydrogel bandage for its ability to secure sutureless pars plana vitrectomy sclerotomies.
  
  
  METHODS
  Laboratory investigation.
  
  
  METHODS
  Twenty-gauge (20-G) and twenty-three gauge (23-G) sclerotomies were constructed in human cadaveric eyes. A total of 24 sclerotomies were constructed in 6 eyes. Four sclerotomies per eye were constructed. Two were straight 20-G incisions, of which 1 was sutured and 1 was covered with the bandage. The other 2 were 23-G beveled incisions, of which 1 was left bare and the other was closed with the hydrogel bandage. India ink was applied over the sclerotomy sites while the intraocular pressure (IOP) was varied. The presence of India ink particles along incisions was evaluated by histologic analysis.
  
  
  RESULTS
  The hydrogel bandage prevented the entry of ink particles in all covered incisions after IOP modulation and incision manipulation. One 20-G sutured incision showed partial ink ingress. Four uncovered 23-G incisions showed the presence of ink within the inner aspect of the incisions (P = .0455 relative to 23-G sealed incisions). Twenty-two out of 24 incisions were evaluated, as 2 incisions could not be identified on histologic analysis.
  
  
  CONCLUSIONS
  The use of a hydrogel bandage to close sutureless sclerotomies is a practical alternative to sutures. Closure of sutureless sclerotomies may reduce the entry of ocular surface fluid into these incisions as well as prevent leakage of intraocular fluid in the immediate postoperative period. Incision closure may reduce the incidence of postoperative endophthalmitis and hypotony in sutureless vitreous surgery.
authors.affiliation: Department of Surgery, Section of Ophthalmology and Visual Science, University of Chicago, 5841 South Maryland, Chicago, IL 60637, USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Singh
authors.forename: Mojgan
authors.initials: M
authors.lastname: Hosseini
authors.forename: Seenu M
authors.initials: SM
authors.lastname: Hariprasad
mesh_terms: D047070:Bandages, Hydrocolloid; D002244:Carbon / Q000378:metabolism; D006801:Humans; D007281:Ink; D011092:Polyethylene Glycols; D012590:Sclera / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D012599:Sclerostomy; D013529:Surgical Wound Dehiscence / Q000378:metabolism / Q000517:prevention & control; D013536:Suture Techniques; D014945:Wound Healing
chemical_list: C028433:chinese ink; D011092:Polyethylene Glycols; D002244:Carbon