title: Challenges in the chemical synthesis of average sized proteins: sequential vs. convergent ligation of multiple peptide fragments.
abstract: This review examines the challenges in the chemical synthesis of average sized proteins. Recent progress on sequential and convergent ligation methods, two approaches to the synthesis of proteins, is outlined. An examination of these challenges could aid in the process of finding new methodologies for the efficient chemical synthesis of average sized protein molecules.
authors.affiliation: Department of Chemistry, Yonsei University, Shinchon 134, Seoul 120-749, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Duhee
authors.initials: D
authors.lastname: Bang
mesh_terms: D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; D011506:Proteins