[The regulatory role of the oxide nitrogen and monoxide carbon under oxidative stress in experimental dyslipidemia].
The condition of the system "prooxidants-antioxidants" in dynamic model alimentary dyslipidemia in Vistar rats of the lines were studied. General antioxidant activities, activities of antioxidant enzymes (katalase, glutathione reductase, glutathione peroxidase), levels of glutathione, products of lipoperoxides in blood and liver, intensive forming of the oxide nitrogen and monoxide carbon were investigated. The role of the signal molecules (oxide nitrogen and monoxide carbon) in regulation oxidative stress was discussed. It is shown that breach of the dynamic balance between synthesis of oxide nitrogen and monoxide carbon displaces the compensation response in the "prooxidants-antioxidants" system. The reinforcement formation of monoxide carbon decreases synthesis of oxide nitrogen by cells, activation of the lipoperoxidation processes, progressive oxidative stress, apoptosis induction signal.
Karaman
Iu K
IuK
Novgorodtseva
T P
TP
Bival'kevich
N V
NV
Lobanova
E G
EG
Ian'kova
V I
VI
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism*; D050171:Dyslipidemias / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D009589:Nitrogen Oxides / Q000378:metabolism*; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D009589:Nitrogen Oxides; D002248:Carbon Monoxide; D010088:Oxidoreductases