Effect of vesicle traps on traffic jam formation in fast axonal transport.
The purpose of this paper is to develop a model for simulation of the formation of organelle traps in fast axonal transport. Such traps may form in the regions of microtubule polar mismatching. Depending on the orientation of microtubules pointing toward the trap region, these traps can accumulate either plus-end or minus-end oriented vesicles. The model predicts that the maximum concentrations of organelles occur at the boundaries of the trap regions; the overall concentration of organelles in the axon with traps is greatly increased compared to that in a healthy axon, which is expected to contribute to mechanical damages of the axon. The organelle traps induce hindrance to organelle transport down the axon; the total organelle flux down the axon with traps is found to be significantly reduced compared to that in a healthy axon.
Kuznetsov
A V
AV
Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC 27695-7910, USA. avkuznet@eos.ncsu.edu
D000465:Algorithms; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000473:pathology / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008870:Microtubules / Q000378:metabolism; D008959:Models, Neurological; D020409:Molecular Motor Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015388:Organelles / Q000502:physiology*
D020409:Molecular Motor Proteins