title: microRNA-181b targets MLK2 in HL-60 cells.
abstract: microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
authors.affiliation: The First Affiliated Hospital of Harbin Medical University, Harbin, 150101, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Harbin Acheng District People's Hospital, Harbin, 150300, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Graduate department of Harbin Medical University, Harbin, 150001, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
authors.affiliation: The First Affiliated Hospital of Harbin Medical University, Harbin, 150101, China. miyanok@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mi
mesh_terms: D001483:Base Sequence; D015153:Blotting, Western; D049109:Cell Proliferation; D002470:Cell Survival; D015973:Gene Expression Regulation, Leukemic; D018922:HL-60 Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020930:MAP Kinase Kinase Kinases / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection
chemical_list: C540193:MIrn181 microRNA, human; D035683:MicroRNAs; D020930:MAP Kinase Kinase Kinases; C093290:MAP3K10 protein, human