Cardiac computed tomography for prediction of myocardial viability after reperfused acute myocardial infarction.
BACKGROUND
Perfusion defects (PDs) detected with cardiac magnetic resonance (CMR) imaging predict the functional recovery of myocardial function after acute myocardial infarction.


OBJECTIVE
We evaluated the ability of cardiac computed tomography (CCT) to predict the recovery of regional left ventricular (LV) systolic function after ST elevation myocardial infarction (STEMI).


METHODS
Seventeen patients (mean age, 60610 years) presenting with STEMI were prospectively studied. Each patient underwent CCT and CMR at baseline and after an average of 6 months. Areas of PD were quantified. Segmental LV systolic function was semiquantitatively assessed by CMR. An improvement at 6 months by R1 category in the regional wall motion score was considered LV recovery.


RESULTS
Coronary artery revascularization was successfully performed with post procedural TIMI 3 flow in 16 cases. On CCT assessment, 107 of 289 segments (37%) had some degree of PD. On follow-up, segments with,25%PD at baseline had no worsening of wall motion. In segments with.75%PD, 89% (9 of 11) showed akinesis or worsening of wall motion. The odds ratio for improvement in segmental wall motion with increasing PD category was 0.63 (95% CI, 0.42-0.97; P 5 0.035). The degree of PD on CT predicted LV recovery at follow-up (P , 0.0001).


CONCLUSIONS
The transmural extent of myocardial infarction as detected and quantified with CCT predicts the recovery of regional systolic LV function after revascularization for acute STEMI.
Shapiro
Michael D
MD
Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sarwar
Ammar
A
Nieman
Koen
K
Nasir
Khurram
K
Brady
Thomas J
TJ
Cury
Ricardo C
RC
D000368:Aged; D016009:Chi-Square Distribution; D003287:Contrast Media; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D016015:Logistic Models; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009204:Myocardial Revascularization; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted; D020127:Recovery of Function; D013997:Time Factors; D014022:Tissue Survival; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014283:Triiodobenzoic Acids; D016277:Ventricular Function, Left
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol