title: BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu2+ in living cells.
abstract: A new fluoro-chromogenic chemosensor based on BODIPY-functionalized gold nanoparticles 1 is prepared. Addition of Cu(2+) ions to aqueous solutions of 1 gave an instantaneous color change along with a blue-shift of the absorption band and quenching of the emission spectrum at room temperature. The chemosensor 1 exhibits a high affinity and selectivity for Cu(2+) over competing metal ions tested. Moreover, confocal microscopy experiments establish that 1 can be used for detecting Cu(2+) levels within living cells.
authors.affiliation: Department of Chemistry and Research Institute of Natural Science, Gyeongsang National University, Jinju 660-701, S. Korea.
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Hyunjong
authors.initials: H
authors.lastname: Son
authors.forename: Jung Mi
authors.initials: JM
authors.lastname: Lim
authors.forename: Jungmin
authors.initials: J
authors.lastname: Oh
authors.forename: Dongmin
authors.initials: D
authors.lastname: Kang
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Han
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D003300:Copper / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence
chemical_list: D006046:Gold; D003300:Copper