title: Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity.
abstract: Chemical investigation of the tubers of Corydalis ternata resulted in the isolation and characterization of four new benzylisoquinoline alkaloids, epi-coryximine (1) and coryternatines A-C (2-4), along with 10 known alkaloids (5-14). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. In addition, the cytotoxicities of the alkaloids (1-14) were evaluated by determining their inhibitory effects on several human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) using the SRB assay. Compound 8 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC(50)=8.34, 5.14, 7.87, and 2.86 microM, respectively). The four new compounds (1-4) exhibited selective cytotoxicity against the HCT-15 cell line.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Jangan-ku, Suwon 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Il Kyun
authors.initials: IK
authors.lastname: Lee
authors.forename: Cheng Jie
authors.initials: CJ
authors.lastname: Piao
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Jei Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Yeong Shik
authors.initials: YS
authors.lastname: Kim
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D044182:Benzylisoquinolines / Q000737:chemistry*; D045744:Cell Line, Tumor; D031311:Corydalis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D035281:Plant Tubers / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines