title: Developmental changes of radiological findings in Fukuyama-type congenital muscular dystrophy.
abstract: Fukuyama-type congenital muscular dystrophy (FCMD) is characterized by congenital muscular dystrophy and associated with neuropathological anomalies. However, the issue of whether the radiological findings of white-matter lesions represent delayed myelination, demyelination or other problems remains controversial. We present serial radiological findings, including MR spectroscopy (MRS), in a child with FCMD. These findings indicate a correlation between the imaging abnormalities and the choline/creatine ratio, suggesting the possible usefulness of MRS in addition to MRI for following FCMD patients.
authors.affiliation: Molecular and Cellular Biology, Harvard University, Cambridge, USA. zen-k@gifu-u.ac.jp
authors.forename: Zenichiro
authors.initials: Z
authors.lastname: Kato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Morimoto
authors.forename: Kenji E
authors.initials: KE
authors.lastname: Orii
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kato
authors.forename: Naomi
authors.initials: N
authors.lastname: Kondo
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002794:Choline / Q000032:analysis*; D003401:Creatine / Q000032:analysis*; D003711:Demyelinating Diseases / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D058494:Walker-Warburg Syndrome / Q000150:complications* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D003401:Creatine; D002794:Choline