title: Testicular cancer survivorship: research strategies and recommendations.
abstract: Testicular cancer represents the most curable solid tumor, with a 10-year survival rate of more than 95%. Given the young average age at diagnosis, it is estimated that effective treatment approaches, in particular, platinum-based chemotherapy, have resulted in an average gain of several decades of life. This success, however, is offset by the emergence of considerable long-term morbidity, including second malignant neoplasms, cardiovascular disease, neurotoxicity, nephrotoxicity, pulmonary toxicity, hypogonadism, decreased fertility, and psychosocial problems. Data on underlying genetic or molecular factors that might identify those patients at highest risk for late sequelae are sparse. Genome-wide association studies and other translational molecular approaches now provide opportunities to identify testicular cancer survivors at greatest risk for therapy-related complications to develop evidence-based long-term follow-up guidelines and interventional strategies. We review research priorities identified during an international workshop devoted to testicular cancer survivors. Recommendations include 1) institution of lifelong follow-up of testicular cancer survivors within a large cohort setting to ascertain risks of emerging toxicities and the evolution of known late sequelae, 2) development of comprehensive risk prediction models that include treatment factors and genetic modifiers of late sequelae, 3) elucidation of the effect(s) of decades-long exposure to low serum levels of platinum, 4) assessment of the overall burden of medical and psychosocial morbidity, and 5) the eventual formulation of evidence-based long-term follow-up guidelines and interventions. Just as testicular cancer once served as the paradigm of a curable malignancy, comprehensive follow-up studies of testicular cancer survivors can pioneer new methodologies in survivorship research for all adult-onset cancer.
authors.affiliation: Department of Radiation Oncology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA. lois_travis@urmc.rochester.edu
authors.forename: Lois B
authors.initials: LB
authors.lastname: Travis
authors.forename: Clair
authors.initials: C
authors.lastname: Beard
authors.forename: James M
authors.initials: JM
authors.lastname: Allan
authors.forename: Alv A
authors.initials: AA
authors.lastname: Dahl
authors.forename: Darren R
authors.initials: DR
authors.lastname: Feldman
authors.forename: Jan
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Gedske
authors.initials: G
authors.lastname: Daugaard
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kelly
authors.forename: M Eileen
authors.initials: ME
authors.lastname: Dolan
authors.forename: Robyn
authors.initials: R
authors.lastname: Hannigan
authors.forename: Louis S
authors.initials: LS
authors.lastname: Constine
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Oeffinger
authors.forename: Paul
authors.initials: P
authors.lastname: Okunieff
authors.forename: Greg
authors.initials: G
authors.lastname: Armstrong
authors.forename: David
authors.initials: D
authors.lastname: Wiljer
authors.forename: Robert C
authors.initials: RC
authors.lastname: Miller
authors.forename: Jourik A
authors.initials: JA
authors.lastname: Gietema
authors.forename: Flora E
authors.initials: FE
authors.lastname: van Leeuwen
authors.forename: Jacqueline P
authors.initials: JP
authors.lastname: Williams
authors.forename: Craig R
authors.initials: CR
authors.lastname: Nichols
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Einhorn
authors.forename: Sophie D
authors.initials: SD
authors.lastname: Fossa
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000235:genetics; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D004651:Employment; D019317:Evidence-Based Medicine; D005221:Fatigue / Q000139:chemically induced; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced / Q000235:genetics; D008297:Male; D015233:Models, Statistical; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D016609:Neoplasms, Second Primary / Q000517:prevention & control; D010292:Paresthesia / Q000139:chemically induced / Q000235:genetics; D017671:Platinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D011159:Population Surveillance; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000235:genetics; D011788:Quality of Life; D051437:Renal Insufficiency / Q000139:chemically induced / Q000235:genetics; D018570:Risk Assessment; D015996:Survival Rate; D017741:Survivors / Q000706:statistics & numerical data*; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000523:psychology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds