How to manage an unresectable or recurrent sialoblastoma.
Only 2-5% of all salivary gland tumors occur in children. Sialoblastoma is an extremely rare salivary gland tumor diagnosed at birth or shortly thereafter with significant variability in histological range and clinical course, so that it may be difficult to predict the most appropriate therapy. In cases where surgical removal is not curative or technically feasible, chemotherapy may be attempted. We report herein a patient with progression of a huge partially resected sialoblastoma who was successfully treated with chemotherapy. Systemic chemotherapy with vincristine, actinomycin D, and cyclophosphamide (VAC) seems to be an effective adjuvant or neoadjuvant treatment option for unresectable or recurrent sialoblastoma.
Saribeyoglu
Ebru Tugrul
ET
Department of Pediatric Hematology-Oncology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. ebrusaribeyoglu@gmail.com
Devecioglu
Omer
O
Karakas
Zeynep
Z
Anak
Sema
S
Unuvar
Aysegul
A
Agaoglu
Leyla
L
Celik
Aladdin
A
Gulluoglu
Mine
M
Bilgic
Bilge
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D019468:Disease Management; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D012468:Salivary Gland Neoplasms / Q000151:congenital* / Q000188:drug therapy* / Q000601:surgery; D016879:Salvage Therapy; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide