title: Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.
abstract: Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1(+/-)Hipk2(-/-) mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.
authors.affiliation: Department of Ophthalmology and Visual Science, Kumamoto University, Graduate School of Medical Sciences, Kumamoto, Japan. noel@da2.so-net.ne.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Inoue
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kagawa
authors.forename: Miyuki
authors.initials: M
authors.lastname: Inoue-Mochita
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Isono
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohtsu
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nobuhisa
authors.forename: Mikiko
authors.initials: M
authors.lastname: Fukushima
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Taga
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics; D005123:Eye / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D007908:Lens, Crystalline / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000235:genetics; D012160:Retina / Q000378:metabolism; D012172:Retinaldehyde / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D012172:Retinaldehyde