Host response to influenza virus: protection versus immunopathology.
Host responses play crucial roles in defense against influenza but sometimes these may contribute to immunopathology. Potentially, this may be more important in disease caused by viruses such as avian influenza A H5N1 or the 1918 H1N1 influenza virus rather than with seasonal influenza or pandemic H1N1 2009 (pdmH1N1). Understanding pathogenesis will help develop novel therapeutic options that minimize immunopathology without impairing beneficial host defenses.
Peiris
J S M
JS
Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. malik@hkucc.hku.hk
Hui
Kenrie P Y
KP
Yen
Hui-Ling
HL
D056704:Adaptive Immunity; D000818:Animals; D001717:Birds; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology / Q000517:prevention & control*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*