title: Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.
abstract: To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (Abeta1-42), Abeta1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P <or= 0.001). Ratios of P-tau/T-tau were significantly different in Parkinsonian syndromes. CSF Abeta1-42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and Abeta1-42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes.
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.
authors.forename: Sigurd D
authors.initials: SD
authors.lastname: Süssmuth
authors.forename: Ingo
authors.initials: I
authors.lastname: Uttner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Landwehrmeyer
authors.forename: Elmar H
authors.initials: EH
authors.lastname: Pinkhardt
authors.forename: Johannes
authors.initials: J
authors.lastname: Brettschneider
authors.forename: Axel
authors.initials: A
authors.lastname: Petzold
authors.forename: Bernd
authors.initials: B
authors.lastname: Kramer
authors.forename: Jörg B
authors.initials: JB
authors.lastname: Schulz
authors.forename: Christian
authors.initials: C
authors.lastname: Palm
authors.forename: Markus
authors.initials: M
authors.lastname: Otto
authors.forename: Albert C
authors.initials: AC
authors.lastname: Ludolph
authors.forename: Jan
authors.initials: J
authors.lastname: Kassubek
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Tumani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000134:cerebrospinal fluid*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D018709:Statistics, Nonparametric; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D005904:Glial Fibrillary Acidic Protein; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins