Ziprasidone induced tardive cervical dystonia.
Fifty years old female patient used 80 mg/day ziprasidone for 4 months after diagnosed as atypical depression. After 4 months of ziprasidone treatment, involuntary movements appeared in her neck region. Ziprasidone was stopped in by tapering 20 mg/day, but the involuntary movements continued and even exacerbated. Then, oral clonazepam treatment was started but no improvement was observed. Finally, she was administered Botulinum Toxin A (BTX-A) treatment. After the fourth BTX-A injection therapy, significant reduction in neck pain and improvement of head deviation was observed.
Kutlu
Ayse
A
Kocaeli University, School of Medicine, Neurology Department, Kocaeli, Turkey. draysekutlu@yahoo.com
Dündar
Senem
S
Altun
Nur S
NS
Budak
Faik
F
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D009465:Neuromuscular Agents; D010879:Piperazines; D013844:Thiazoles; D002998:Clonazepam; C092292:ziprasidone; D019274:Botulinum Toxins, Type A