title: Brown tumors in patients with chronic renal failure and secondary hyperparathyroidism: report of 12 cases.
abstract: Brown tumors are unusual but serious complications of renal osteodystrophy. We retrospectively studied 12 patients presenting with chronic renal failure and brown tumor related to secondary hyperparathyroidism. Eleven patients were on chronic hemodialysis. The median duration between renal failure and end stage renal failure was 36 months (range: 12-190 months) and the median duration in dialysis for 11 cases: 92 months (range: 72-252 months). The bone pain was noted in all cases (100%), pathological fracture in one case (8%) and a palpable bone tumor in 10 cases (83%). Elevated serum calcium (> 2.35 mmol/L) was noted in four cases (33%), elevated serum Phosphate (> 1.78 mmol/L) in ten cases (80%), elevated serum alkaline phosphate (> 290 UI/L) in all cases and intact PTH was > 300 pg/mL in all cases with a serum median rate at 1475 pg/mL (range: 682-3687 pg/L). Subtotal parathyroidectomy was performed in all cases with a resultant decrease in size of brown tumors. We report here patient with CKD with unusual frequency and variable locations. This may be attributed to the lack of the new calcium free phosphate binders and calcimimetics.
authors.affiliation: Department of Nephrology and Internal Medicine, Charles Nicolle Hospital, and Laboratory of Kidney Pathology, Tunis, Tunisia. liliabf@voila.fr
authors.forename: Lilia Ben
authors.initials: LB
authors.lastname: Fatma
authors.forename: Samia
authors.initials: S
authors.lastname: Barbouch
authors.forename: Ben Hamida
authors.initials: BH
authors.lastname: Fethi
authors.forename: Ben Abdallah
authors.initials: BA
authors.lastname: Imen
authors.forename: Khiari
authors.initials: K
authors.lastname: Karima
authors.forename: Helal
authors.initials: H
authors.lastname: Imed
authors.forename: El Younsi
authors.initials: el Y
authors.lastname: Fethi
authors.forename: Ben Moussa
authors.initials: BM
authors.lastname: Fatma
authors.forename: Goucha
authors.initials: G
authors.lastname: Rim
authors.forename: Ben Abdallah
authors.initials: BA
authors.lastname: Taieb
authors.forename: Hedi Ben
authors.initials: HB
authors.lastname: Maiz
authors.forename: Khedher
authors.initials: K
authors.lastname: Adel
mesh_terms: D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications* / Q000000981:diagnostic imaging; D015726:Giant Cells / Q000473:pathology*; D006099:Granuloma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000097:blood; D006962:Hyperparathyroidism, Secondary / Q000209:etiology* / Q000601:surgery; D054559:Hyperphosphatemia / Q000097:blood; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology; D016105:Parathyroidectomy; D011859:Radiography; D013997:Time Factors