title: 2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
abstract: Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors.
authors.affiliation: Merck Research Laboratories, MSD, Newhouse, Lanarkshire ML1 5SH, UK. jiaqiang.cai@merck.com
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Cai
authors.forename: D Jonathan
authors.initials: DJ
authors.lastname: Bennett
authors.forename: Zoran
authors.initials: Z
authors.lastname: Rankovic
authors.forename: Maureen
authors.initials: M
authors.lastname: Dempster
authors.forename: Xavier
authors.initials: X
authors.lastname: Fradera
authors.forename: Jonathan
authors.initials: J
authors.lastname: Gillespie
authors.forename: Iain
authors.initials: I
authors.lastname: Cumming
authors.forename: William
authors.initials: W
authors.lastname: Finlay
authors.forename: Mark
authors.initials: M
authors.lastname: Baugh
authors.forename: Sylviane
authors.initials: S
authors.lastname: Boucharens
authors.forename: John
authors.initials: J
authors.lastname: Bruin
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Cameron
authors.forename: William
authors.initials: W
authors.lastname: Hamilton
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kerr
authors.forename: Emma
authors.initials: E
authors.lastname: Kinghorn
authors.forename: George
authors.initials: G
authors.lastname: McGarry
authors.forename: John
authors.initials: J
authors.lastname: Robinson
authors.forename: Paul
authors.initials: P
authors.lastname: Scullion
authors.forename: Joost C M
authors.initials: JC
authors.lastname: Uitdehaag
authors.forename: Mario
authors.initials: M
authors.lastname: van Zeeland
authors.forename: Dominique
authors.initials: D
authors.lastname: Potin
authors.forename: Laurent
authors.initials: L
authors.lastname: Saniere
authors.forename: Andre
authors.initials: A
authors.lastname: Fouquet
authors.forename: Francois
authors.initials: F
authors.lastname: Chevallier
authors.forename: Hortense
authors.initials: H
authors.lastname: Deronzier
authors.forename: Cecile
authors.initials: C
authors.lastname: Dorleans
authors.forename: Eric
authors.initials: E
authors.lastname: Nicolai
mesh_terms: D020134:Catalytic Domain; D056657:Cathepsin K / Q000037:antagonists & inhibitors / Q000378:metabolism; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002460:Cell Line; D003198:Computer Simulation; D006801:Humans; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry
chemical_list: C553257:2-phenyl-9H-purine-6-carbonitrile; D009570:Nitriles; D011480:Protease Inhibitors; D011687:Purines; D011743:Pyrimidines; D002403:Cathepsins; C028217:cathepsin S; D056657:Cathepsin K; C030986:pyrimidine