title: US-guided application of a new hybrid probe in human pancreatic adenocarcinoma: an ex vivo study.
abstract: BACKGROUND
  Ablative therapies such as radiofrequency and cryotechnology are widely used in oncological intervention but not in the pancreatic field because of their high operative risks. A new flexible bipolar ablation device (Cryotherm probe [CTP]) was developed combining radiofrequency and cryotechnology.
  
  
  OBJECTIVE
  To evaluate the efficacy of the CTP in destroying neoplastic tissue of explanted pancreatic tumors of patients with pancreatic adenocarcinoma.
  
  
  METHODS
  Ex vivo clinical study.
  
  
  METHODS
  Inpatient hospital setting.
  
  
  METHODS
  This study involved 16 explanted pancreatic tumors from 16 patients.
  
  
  METHODS
  CTP application was performed on explanted pancreatic tumors. Anatomic specimens were divided into 4 groups; each group received a predefined application time of 120 to 600 seconds.
  
  
  METHODS
  The coagulation diameter (short axis) perpendicular to the device's longitudinal axis was used as the primary outcome measure.
  
  
  RESULTS
  All pancreatic specimens showed histological signs of coagulative necrosis. There was a positive correlation between the short axis of the obtained necrosis and duration of application (r = 0.74).
  
  
  CONCLUSIONS
  This study was an ex vivo study with all limitations typical of this kind of study.
  
  
  CONCLUSIONS
  The CTP is effective in destroying neoplastic pancreatic tissue, creating an ablation zone, the extent of which is related to the duration of application.
authors.affiliation: Division of Gastroenterology and Gastrointestinal Endoscopy, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, 20132 Milan, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Petrone
authors.forename: Paolo Giorgio
authors.initials: PG
authors.lastname: Arcidiacono
authors.forename: Silvia
authors.initials: S
authors.lastname: Carrara
authors.forename: Luca
authors.initials: L
authors.lastname: Albarello
authors.forename: Markus D
authors.initials: MD
authors.lastname: Enderle
authors.forename: Alexander
authors.initials: A
authors.lastname: Neugebauer
authors.forename: Cinzia
authors.initials: C
authors.lastname: Boemo
authors.forename: Claudio
authors.initials: C
authors.lastname: Doglioni
authors.forename: Pier Alberto
authors.initials: PA
authors.lastname: Testoni
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000295:instrumentation*; D003452:Cryosurgery / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography