Endoscopic full-thickness resection and defect closure in the colon.
BACKGROUND
Endoscopic full-thickness resection (eFTR) is a minimally invasive method for en bloc resection of GI lesions.


OBJECTIVE
The aim of this pilot study was to evaluate the feasibility of a grasp-and-snare technique for eFTR combined with an over-the-scope clip (OTSC) for defect closure.


METHODS
Nonsurvival animal study.


METHODS
Animal laboratory.


METHODS
Fourteen female domestic pigs.


METHODS
The eFTR was performed in porcine colons using a novel tissue anchor in combination with a standard monofilament snare and 14 mm OTSC. In the first group (n = 20), closure of the colonic defects with OTSC was attempted after the resection. In the second group (n = 8), an endoloop was used to secure the resection base before eFTR was performed.


RESULTS
In the first group (n = 20), eFTR specimens ranged from 2.4 to 5.5 cm in diameter. Successful closure was achieved in 9 out of 20 cases. Mean burst pressure for OTSC closure was 29.2 mm Hg (range, 2-90; SD, 29.92). Injury to adjacent organs occurred in 3 cases. Lumen obstruction due to the OTSC closure occurred in 3 cases. In the second group (n = 8), the diameter of specimens ranged from 1.2 to 2.2 cm. Complete closure was achieved in all cases, with a mean burst pressure of 76.6 mm Hg (range, 35-120; SD, 31). Lumen obstruction due to the endoloop closure occurred in one case. No other complications or injuries were observed in the second group.


CONCLUSIONS
Nonsurvival setting.


CONCLUSIONS
Colonic eFTR using the grasp-and-snare technique is feasible in an animal model. Ligation of the resection base with an endoloop before eFTR seems to reduce complication rates and improve closure success and leak test results despite yielding smaller specimens.
von Renteln
Daniel
D
Department of Gastroenterology, Medizinische Klinik I, Klinikum Ludwigsburg, 71640 Ludwigsburg, Germany. renteln@gmx.net
Schmidt
Arthur
A
Vassiliou
Melina C
MC
Rudolph
Hans-Ulrich
HU
Caca
Karel
K
D000818:Animals; D003082:Colectomy / Q000379:methods*; D003108:Colonic Diseases / Q000601:surgery*; D003113:Colonoscopy / Q000379:methods*; D004195:Disease Models, Animal; D004210:Dissection / Q000379:methods; D005260:Female; D007413:Intestinal Mucosa / Q000601:surgery*; D010865:Pilot Projects; D015203:Reproducibility of Results; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine