Neurotoxicity of cancer chemotherapy.
Neurologic dysfunction is a common side effect of many chemotherapy drugs. For several agents, neurotoxicity is common, severe, and can be dose-limiting. As the list of newer chemotherapy agents and systemic "targeted therapies" grows, so does the number and variety of potential neurotoxicities. This is a review of the clinical features of chemotherapy-induced syndromes involving the central and peripheral nervous systems.
Dropcho
Edward J
EJ
Department of Neurology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA. edropcho@iupui.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy
D000970:Antineoplastic Agents