FBXO7 gene mutations may be rare in Chinese early-onset Parkinsonism patients.
A recent study has shown that FBXO7 is a causative gene for PARK15-linked autosomal recessive early-onset Parkinsonism which was described by Davison for the first time in 1954 and known as Pallido-Pyramidal Disease or Parkinsonia-Pyramidal Syndrome in the past. In order to investigate the characteristics of FBXO7 gene mutations in Chinese early-onset Parkinsonism patients, we performed polymerase chain reaction and DNA direct sequencing on 135 patients and 200 controls. In this study, we found 10 polymorphisms including two novel polymorphisms (-274G-->C, c.A155G), but no pathogenetic mutations in the FBXO7 gene were detected. This suggests that FBXO7 mutations may be rare in Chinese early-onset Parkinsonism patients.
Luo
Lin-zi
LZ
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, PR China.
Xu
Qian
Q
Guo
Ji-feng
JF
Wang
Lei
L
Shi
Chang-he
CH
Wei
Jiao-hua
JH
Long
Zhi-gao
ZG
Pan
Qian
Q
Tang
Bei-sha
BS
Xia
Kun
K
Yan
Xin-xiang
XX
D000328:Adult; D017668:Age of Onset; D044466:Asian People; D002681:China; D044783:F-Box Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D020734:Parkinsonian Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic
D044783:F-Box Proteins; C489149:FBXO7 protein, human