title: Vaginal involvement in genital erosive lichen planus.
abstract: A specialized Vulva Clinic with dedicated gynecologists and dermatologists was established in Oslo, Norway, in 2003. Fifty-eight women referred to the clinic in 2003-2009 were diagnosed with genital erosive lichen planus. All patients filled out a questionnaire. Gynecological examination, including vaginal inspection, was performed, if necessary in general anesthesia. Median age at symptom start was 51 years (range 17-78 years) with 15 women (26%) being younger than 40 years old. Sexual abstinence was reported by 36 women and dyspareunia by another 10. On examination, vaginal involvement was seen in 49 women, including vaginal synechiae in 29 and total obliteration of the vagina in 9. Of 56 women treated with topical corticosteroids for at least three months, two had complete response and 36 partial responses. Similarly, of 22 women treated with tacrolimus, three had complete and six partial response. We conclude that vaginal involvement is more common in genital erosive lichen planus than previously reported.
authors.affiliation: The National Resource Centre for Women's Health, Oslo University Hospital, Norway. anneliseord@yahoo.no
authors.forename: Anne Lise Ording
authors.initials: AL
authors.lastname: Helgesen
authors.forename: Petter
authors.initials: P
authors.lastname: Gjersvik
authors.forename: Peter
authors.initials: P
authors.lastname: Jebsen
authors.forename: Rolf
authors.initials: R
authors.lastname: Kirschner
authors.forename: Tom
authors.initials: T
authors.lastname: Tanbo
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001707:Biopsy, Needle; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D008010:Lichen Planus / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009664:Norway; D011788:Quality of Life; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome; D014623:Vaginal Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D014845:Vulvar Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus