title: Association of ABO blood groups with Chikungunya virus.
abstract: Chikungunya virus (CHIKV) an emerging arboviral infection of public health concern belongs to the genus Alphavirus, family Togaviridae. Blood group antigens are generally known to act as receptors for various etiological agents. The studies defining the relationship between blood groups and CHIKV is limited and hence it is necessary to study these parameters in detail. In the present study 1500 subjects were enrolled and demographic data (Age, Gender, Blood group, CHIKV infection status, and CHIKV infection confirmation mode) was collected from them. The risk of acquiring CHIKV disease and its association with factors such as blood group, age and gender was analyzed statistically. The data of this study showed a possible association between blood group, age and gender of the study population with CHIKV infection. It is observed that CHIKV infections were higher in individuals with Rh positive blood group when compared to their Rh negative counterparts.CHIKV infections were found to be higher in Rh positive individuals of AB and A blood groups than that of Rh negative counterparts. Results also indicated that infections were higher in adults belonging to the age group > 30 years and also higher in males as compared to females enrolled in this study. These data present further evidence for the association of the blood groups, age and gender to susceptibility to CHIKV infection. Further studies are needed to confirm these findings. This is the second study showing the possible association of blood groups with chikungunya.
authors.affiliation: Department of Virology, College of Sciences, Sri Venkateswara University, Tirupati 517502, India.
authors.forename: Naresh C V M
authors.initials: NC
authors.lastname: Kumar
authors.forename: Mahathi
authors.initials: M
authors.lastname: Nadimpalli
authors.forename: Vishnu R
authors.initials: VR
authors.lastname: Vardhan
authors.forename: Sai D V R
authors.initials: SD
authors.lastname: Gopal
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018354:Alphavirus Infections / Q000097:blood* / Q000821:virology; D002646:Chikungunya virus / Q000302:isolation & purification / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System / Q000097:blood; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System