title: Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives.
abstract: Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.
authors.affiliation: Discovery Research Laboratories, Eisai Co., Ltd, Tsukuba-shi, Ibaraki 300-2635, Japan. k3-nakamoto@hhc.eisai.co.jp
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nakamoto
authors.forename: Itaru
authors.initials: I
authors.lastname: Tsukada
authors.forename: Keigo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsukura
authors.forename: Toru
authors.initials: T
authors.lastname: Haneda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Norio
authors.initials: N
authors.lastname: Murai
authors.forename: Shinya
authors.initials: S
authors.lastname: Abe
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ueda
authors.forename: Mamiko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Naoaki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Asada
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshimatsu
authors.forename: Katsura
authors.initials: K
authors.lastname: Hata
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000577:Amides; D000935:Antifungal Agents; D005656:Fungal Proteins; D011725:Pyridines; D011804:Quinolines; C037219:quinoline; C023666:pyridine