title: Fluoride and chlorhexidine release from filled resins.
abstract: Resin-based materials that release either fluoride or chlorhexidine have been formulated for inhibiting caries activity. It is not known if the two agents, when incorporated into one material, would interact and affect their release potential. We hypothesized that the ratio of fluoride to chlorhexidine incorporated into a resin, and the pH of the storage medium, will affect their releases from the material. The material investigated contained 23 wt% of filler, and the ratios of calcium fluoride to chlorhexidine diacetate were 8/2, 5/5, and 2/8. The release was conducted in pH 4, 5, and 6 acetate buffers. The results showed that release of either agent increased as the pH of the medium decreased. The presence of fluoride salt substantially reduced the chlorhexidine release, while the presence of a specific quantity of chlorhexidine significantly increased fluoride release. This interaction can be utilized to optimize the release of either agent for therapeutic purposes.
authors.affiliation: Department of Prosthodontics, College of Dentistry, University of Florida, PO Box 100435, 1600 SW Archer Rd., Gainesville, FL 32610-0435, USA. cshen@dental.ufl.edu
authors.forename: C
authors.initials: C
authors.lastname: Shen
authors.forename: N-Z
authors.initials: NZ
authors.lastname: Zhang
authors.forename: K J
authors.initials: KJ
authors.lastname: Anusavice
mesh_terms: D000704:Analysis of Variance; D002124:Calcium Fluoride / Q000494:pharmacology*; D002327:Cariostatic Agents / Q000494:pharmacology*; D002710:Chlorhexidine / Q000494:pharmacology*; D003188:Composite Resins / Q000737:chemistry*; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D012044:Regression Analysis
chemical_list: D002327:Cariostatic Agents; D003188:Composite Resins; D002124:Calcium Fluoride; D002710:Chlorhexidine