title: Shear wave dispersion ultrasonic vibrometry for measuring prostate shear stiffness and viscosity: an in vitro pilot study.
abstract: This paper reports shear stiffness and viscosity "virtual biopsy" measurements of the three excised noncancerous human prostates using a new tool known as shear wave dispersion ultrasound vibrometry (SDUV) in vitro. Improved methods for prostate guided-biopsy are required to effectively guide needle biopsy to the suspected site. In addition, tissue stiffness measurement helps in identifying a suspected site to perform biopsy because stiffness has been shown to correlate with pathologies, such as cancerous tissue. More importantly, early detection of prostate cancer may guide minimally invasive therapy and eliminate insidious procedures. In this paper, "virtual biopsies" were taken in multiple locations in three excised prostates; SDUV shear elasticity and viscosity measurements were performed at the selected "suspicious" locations within the prostates. SDUV measurements of prostate elasticity and viscosity are generally in agreement with preliminary values previously reported in the literature. It is, however, important to emphasize here that the obtained viscoelastic parameters values are local, and not a mean value for the whole prostate.
authors.affiliation: Department of Physiology and Biomedical Engineering,Mayo Clinic, Rochester, MN 55905 USA. mitri@lanl.gov
authors.forename: F G
authors.initials: FG
authors.lastname: Mitri
authors.forename: M W
authors.initials: MW
authors.lastname: Urban
authors.forename: M
authors.initials: M
authors.lastname: Fatemi
authors.forename: J F
authors.initials: JF
authors.lastname: Greenleaf
mesh_terms: D054459:Elasticity Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D005471:Fluoroscopy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D010865:Pilot Projects; D011467:Prostate / Q000000981:diagnostic imaging* / Q000502:physiology; D014783:Viscosity