Towards a modular synthesis of well-defined chitooligosaccharides: synthesis of the four chitodisaccharides.
The total chemical synthesis of the four well-defined chitodisaccharides is described using N-trichloroacetyl (TCA) and N-benzyloxycarbonyl (Z) as C-2 protecting groups for acetamido and free amino groups, respectively. The synthesis is carried out according to a strategy that paves way to the elaboration of various homo- and hetero-chitooligosaccharides, with perfect control of the number and the position of GlcN and GlcNAc units along the oligomer chain.
Barroca-Aubry
Nadine
N
Laboratoire des Matériaux Polymères et des Biomatériaux, Ingénierie des Matériaux Polymères, UMR CNRS 5223, Université Lyon 1, Domaine scientifique de La Doua, Bât. ISTIL, 15 Bd Latarjet, F-69622 Villeurbanne Cedex, France.
Pernet-Poil-Chevrier
Astrid
A
Domard
Alain
A
Trombotto
Stéphane
S
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002686:Chitin / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D009844:Oligosaccharides; D002686:Chitin