title: Iloperidone for schizophrenia.
abstract: BACKGROUND
  No existing antipsychotic adequately controls all symptoms associated with schizophrenia. Also, no antipsychotic adequately benefits most patients with this disorder. Finally, the safety and tolerability of each antipsychotic frequently dictate the choice of agent.
  
  
  METHODS
  The mechanism of action of iloperidone, its efficacy and its safety and tolerability when used to treat patients with schizophrenia.
  
  
  RESULTS
  An appreciation of the potential advantages and disadvantages of iloperidone when used for the treatment of schizophrenia.
  
  
  CONCLUSIONS
  Iloperidone is a recent addition to the current group of second-generation antipsychotics. While it may share many qualities with other agents in this class, its unique neuroreceptor signature and adverse-effect profile may prove beneficial in clinical practice.
authors.affiliation: Psychiatric Clinical Research Center, Rush University Medical Center, Chicago, IL 60612, USA. Jeffrey_Rado@rush.edu
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rado
authors.forename: Philip G
authors.initials: PG
authors.lastname: Janicak
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017277:Drug Approval; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010597:Pharmacogenetics; D010880:Piperidines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D007555:Isoxazoles; D010880:Piperidines; D012702:Serotonin Antagonists; C081732:iloperidone