N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity.
The in vitro biological activity of N-benzylsalicylthioamides was evaluated against eight fungal strains by the broth microdilution method and the results were compared with those obtained with fluconazole. The compounds exhibited an in vitro antifungal activity against the fluconazole-susceptible as well as the fluconazole-resistant fungal strains. The biological activity was analyzed by quantitative structure-activity relationship (QSAR).
Petrlíková
Eva
E
Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského, Hradec Králové, Czech Republic. Eva.Petrlikova@faf.cuni.cz
Waisser
Karel
K
Buchta
Vladimír
V
Jílek
Petr
P
Vejsová
Marcela
M
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D013854:Thioamides / Q000737:chemistry* / Q000494:pharmacology
D000935:Antifungal Agents; D013854:Thioamides; D015725:Fluconazole