[Effects of Valeriana amurensis on the expressions of beta-APP, Abeta(1-40) and caspase-3 in Alzheimer's disease model rat's brain].
OBJECTIVE
To investigate the effects of Valeriana amurensis on the expressions of P-APP,A4,1 and Caspase-3 of cortical neurons and hippocampus neurons in in Alzheimer's disease model rats' brain.


METHODS
Established the model with multiple factors, observed the expressions of beta-APP, Abeta(1-40) and Caspase-3 of cortical neurons and Hippocampus neurons in in Alzheimer's disease model rats' brain by electron lens using immunohistochemistry method.


RESULTS
The extracts of the roots and rhizomes of Valeriana amurensis decreased the expressions of beta-APP, Abeta(1-40) and Caspase-3 of cortical neurons and hippocampus neurons in in a dose-dependent manner. The effects of high dose of 50% ethanol extract of macroporous resin group were more significant than the other groups'.


CONCLUSIONS
The 50% ethanol extracts of macroporous resin group from the roots and rhizomes of Valeriana amurensis can decrease the expressions of beta-APP, Abeta(1-40), and Caspase-3, to inhibit the formation of senile plaques and neurofibrillary tangles in Alzheimer's disease model rats' brain, and decrease cell fate of cortical neurons and hippocampus neurons in in Alzheimer's disease model rats' brain.
Zuo
Yue-ming
YM
Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Zhang
Zhong-li
ZL
Wang
Qiu-hong
QH
Xie
Ning
N
Kuang
Hai-xue
HX
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D053148:Caspase 3 / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014632:Valerian / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D004365:Drugs, Chinese Herbal; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C505410:Casp3 protein, rat; D053148:Caspase 3