Cocaethylene: effects on brain systems and behavior.
Cocaethylene is a psychoactive metabolite formed during the combined consumption of cocaine and ethanol. In this brief review, we discuss several well-characterized effects of this metabolite with an emphasis on the neurobiological and behavioral correlates of polydrug addiction. Included herein are the descriptions of some of the changes in trans-synaptic transmission and their relationship to pathological behaviors associated with a chronic, drug-dependent state that may be altered by the spatial or temporal dynamics of cocaethylene.
Horowitz
J M
JM
Medaille College, Department of Social Sciences, Agassiz Circle, Buffalo, New York.
Torres
G
G