Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with positive rechallenge.
BACKGROUND
Pancreatitis is a very rare adverse effect of tamoxifen with only six cases of tamoxifen-associated pancreatitis reported in the English literature until now. In these cases, rechallenge with tamoxifen was not carried out.


METHODS
We report a case of recurrent severe acute pancreatitis in a 44-year-old female induced by tamoxifen therapy and review the literature with regards to tamoxifen-associated pancreatitis.


CONCLUSIONS
Clinicians should be aware of the risks of developing severe acute pancreatitis when using tamoxifen therapy. If tamoxifen is suspected as the probable causative agent, rechallenge with this drug should be prohibited.
Sakhri
Jaballah
J
Department of Surgery, Farhat Hached Hospital, Sousse, Tunisia. jaballah.sakhri@rns.tn
Ben Salem
Chaker
C
Harbi
Houssem
H
Fathallah
Neila
N
Ltaief
Rached
R
D000208:Acute Disease; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000150:complications*; D010195:Pancreatitis / Q000209:etiology* / Q000378:metabolism; D012008:Recurrence; D012720:Severity of Illness Index; D013629:Tamoxifen / Q000009:adverse effects*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen