title: Non-solid type thyroid carcinoma: a case report of moderately differentiated adenocarcinoma of the thyroid.
abstract: We report the case of a common type papillary thyroid carcinoma (PTC) patient who developed early recurrence and persistent disease even after ablation therapy. The patient was an 80-year-old man that was incidentally found to have a mass lesion in the left lower lobe of his thyroid. A total thyroidectomy and a left side modified radical neck dissection were performed; histological examination revealed a common type PTC. The patient underwent lymph node dissection twice for recurrence and (131)I-Na ablations for fluctuated elevation of serum thyroglobulin. The resected tumor and recurrence in lymph nodes revealed non-solid type papillary carcinoma with mixed features of less well-differentiated morphology, which we suggest included loss of cellular polarity/cohesiveness, tall cells and columnar cells. Immunohistochemistry revealed high a MIB-1 labeling index (15-20%) in both the primary tumor and the metastatic tumor in the lymph nodes. p53 immunoreaction was found positive at very low level (<5%). E-cadherin was faintly positive in a few cells of the primary tumor and negative in the metastatic site. We recently proposed a new classification for follicular cell tumors of the thyroid gland, and this case is an example of moderately-differentiated adenocarcinoma according to our classification.
authors.affiliation: Department of Pathology, Wakayama Medical University, Kimiidera, Wakayama, Japan.
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Liu
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Bai
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Li
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohba
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Ozaki
authors.forename: Emiko
authors.initials: E
authors.lastname: Taniguchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Mori
authors.forename: Kennichi
authors.initials: K
authors.lastname: Kakudo
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D007150:Immunohistochemistry; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D013965:Thyroidectomy
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes