Blood-induced joint disease: the pathophysiology of hemophilic arthropathy.
Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of hemophilic arthropathy has not been fully elucidated, it appears to have similarities with the degenerative joint damage that occurs in osteoarthritis and the inflammatory processes associated with rheumatoid arthritis. This article reviews the potential actions of various blood constituents on joint components that culminate in the development of hemophilic arthropathy.
Valentino
L A
LA
Rush Hemophilia and Thrombophilia Center, Department of Pediatrics, Rush Children's Hospital and Rush University Medical Center, Chicago, IL USA. lvalentino@rush.edu
D001172:Arthritis, Rheumatoid / Q000150:complications / Q000473:pathology; D001177:Arthropathy, Neurogenic / Q000628:therapy*; D001842:Bone and Bones / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D006467:Hemophilia A / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007249:Inflammation; D007592:Joint Diseases / Q000503:physiopathology*; D007596:Joints / Q000098:blood supply* / Q000473:pathology; D010003:Osteoarthritis / Q000150:complications / Q000473:pathology; D013583:Synovial Membrane / Q000473:pathology