title: Validation and prediction of traditional Chinese physical operation on spinal disease using multiple deformation models.
abstract: OBJECTIVE
  Traditional Chinese medical massage is a physical manipulation that achieves satisfactory results on spinal diseases, according to its advocates. However, the method relies on an expert's experience. Accurate analysis and simulation of massage are essential for validation of traditional Chinese physical treatment. The objective of this study is to provide analysis and simulation that can reproducibly verify and predict treatment efficacy.
  
  
  METHODS
  An improved physical multi-deformation model for simulating human cervical spine is proposed. First, the human spine, which includes muscle, vertebrae and inter- vertebral disks, are segmented and reconstructed from clinical CT and MR images. Homogeneous landmark registration is employed to align the spine models before and after the massage manipulation. Central line mass spring and contact FEM deformation models are used to individually evaluate spinal anatomy variations. The response of the human spine during the massage process is simulated based on specific clinical cases.
  
  
  RESULTS
  Ten sets of patient data, including muscle-force relationships, displacement of vertebrae, strain and stress distribution on inter-vertebral disks were collected, including the pre-operation, post-operation and the 3-month follow-up. The simulation results demonstrate that traditional Chinese massage could significantly affect and treat most mild spinal disease.
  
  
  CONCLUSIONS
  A new method that simulates a traditional Chinese medical massage operation on the human spine may be a useful tool to scientifically validate and predict treatment efficacy.
authors.affiliation: School of Software, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Pan
authors.forename: Xubo
authors.initials: X
authors.lastname: Yang
authors.forename: Lixu
authors.initials: L
authors.lastname: Gu
authors.forename: Wenlong
authors.initials: W
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Fang
mesh_terms: D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D020393:Manipulation, Spinal / Q000379:methods*; D008405:Massage / Q000379:methods*; D008516:Medicine, Chinese Traditional; D011237:Predictive Value of Tests; D013122:Spinal Diseases / Q000628:therapy*; D014057:Tomography, X-Ray Computed