Polymorphisms of the prion protein gene (PRNP) in a Serbian population.
Prion diseases are a group of etiologically heterogeneous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
Dimitrijević
Rajna
R
Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Cadez
Ivana
I
Keckarević-Marković
Milica
M
Keckarević
Dusan
D
Kecmanović
Miljana
M
Dobricić
Valerija
V
Savić-Pavićević
Dusanka
D
Brajusković
Goran
G
Romac
Stanka
S
D019943:Amino Acid Substitution / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005820:Genetic Testing; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D008239:Lysine / Q000235:genetics; D008297:Male; D016254:Mutagenesis, Insertional; D009842:Oligopeptides / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D017096:Prion Diseases / Q000208:ethnology / Q000235:genetics; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics*; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics; D017384:Sequence Deletion / Q000235:genetics; D055771:Serbia / Q000208:ethnology
D009842:Oligopeptides; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions; D018698:Glutamic Acid; D008239:Lysine