Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice.
N-Stearoyl-phytosphingosine (SPS) and 4-hydroxysphinganine (phytosphingosine, PS), which are sphingolipids frequently found in mammalian skin, plants, and yeast, have been used as ingredients in cosmetics. In mice, treatment with SPS and PS inhibited histamine-induced scratching behavior and vascular permeability. These agents inhibited the expression of the allergic cytokines, IL-4 and TNF-alpha, and the activation of the transcription factors, NF-kappaB and c-jun, in histamine-stimulated skin tissues. These agents also showed potent anti-histamine effects in the Magnus test using guinea pig ileum. Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF-kappaB and c-jun.
Ryu
Kwon-Ryeol
KR
Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 1, Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea.
Lee
Bomi
B
Lee
In-Ah
IA
Oh
Sekwan
S
Kim
Dong-Hyun
DH
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000627:therapeutic use*; D000982:Antipruritics / Q000737:chemistry / Q000627:therapeutic use*; D002518:Ceramides / Q000627:therapeutic use*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D015847:Interleukin-4 / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011537:Pruritus / Q000188:drug therapy* / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018926:Anti-Allergic Agents; D000982:Antipruritics; D002518:Ceramides; C553174:N-stearoylphytosphingosine; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D006632:Histamine; C012491:phytosphingosine; D013110:Sphingosine