title: Novel carboxyl-amine bonding methods for poly(dimethylsiloxane)-based devices.
abstract: We present a novel bonding technique for poly(dimethylsiloxane) (PDMS)-based devices employing chemical surface modifications at room temperature. PDMS surfaces were functionalized to present primary amine groups, and glass or gold substrates were functionalized to present carboxylic acid groups. Irreversible bonding was achieved by bringing the two surfaces in contact and reacting at room temperature to form peptide bonds between the substrates. Shear tests reveal the bond strengths achieved to be comparable to values obtained using conventional bonding methods. We also describe the use of carboxyl-terminated silanes on gold surfaces to bond amine-modified PDMS devices. Water contact angle measurements and X-ray photoelectron spectroscopy (XPS) confirmed the conjugation, a novel result that expands the variety of surface chemistries available for such bonding.
authors.affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
authors.forename: Eric
authors.initials: E
authors.lastname: Ouellet
authors.forename: Cheng Wei T
authors.initials: CW
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Lee Ling
authors.initials: LL
authors.lastname: Yang
authors.forename: Eric T
authors.initials: ET
authors.lastname: Lagally
mesh_terms: D000588:Amines / Q000737:chemistry*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004864:Equipment and Supplies; D006046:Gold / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D033081:Shear Strength; D012821:Silanes / Q000737:chemistry; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D000588:Amines; D004129:Dimethylpolysiloxanes; D012821:Silanes; D014867:Water; C013830:baysilon; D006046:Gold