Nonspecific biochemical changes under different health statuses and a quantitative model based on biological markers to evaluate systemic function in humans.
BACKGROUND
To investigate the markers of systemic function by using laboratory parameters as life parameters.


METHODS
Lymphocyte count, albumin, and creatinine levels were measured using automatic analyzers in young, healthy individuals (20-39 years) and senior individuals (80-95 years) as well as in terminally ill patients. We developed a mathematic model and scoring system (indexes of systemic function, ISF) based on the above mentioned biological markers.


RESULTS
ISF scores were significantly lower in the senior group (P < 0.05) than those in the young, healthy group. A significant decrease was observed in the ISF of the terminally ill group and that of the senior group (P < 0.05).


CONCLUSIONS
Our results suggest that the ISF scoring system of systemic function can be used to objectively evaluate the systemic function in individuals with different health statuses.
Hongwei
Wang
W
Department of Computer Science, Dalian Medical University, Dalian 116044, China.
Xinyu
Zhao
Z
Guihong
Luan
L
Xiliang
Liu
L
Hui
Liu
L
D000328:Adult; D000369:Aged, 80 and over; D001322:Autoanalysis / Q000379:methods; D015415:Biomarkers / Q000097:blood; D002681:China; D003404:Creatinine / Q000097:blood*; D006304:Health Status; D006801:Humans; D018655:Lymphocyte Count; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*; D013727:Terminal Care; D055815:Young Adult
D015415:Biomarkers; D012709:Serum Albumin; D003404:Creatinine