Visualizing genetic similarity at the symptom level: the example of learning disabilities.
Psychological traits and disorders are often interrelated through shared genetic influences. A combination of maximum-likelihood structural equation modelling and multidimensional scaling enables us to open a window onto the genetic architecture at the symptom level, rather than at the level of latent genetic factors. We illustrate this approach using a study of cognitive abilities involving over 5,000 pairs of twins.
Davis
Oliver S P
OS
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom. Oliver.Davis@iop.kcl.ac.uk
Plomin
Robert
R
D002648:Child; D004200:Diseases in Twins; D006801:Humans; D007859:Learning Disabilities / Q000235:genetics*; D015999:Multivariate Analysis; D012931:Social Environment; D014427:Twins / Q000235:genetics*