Role of histone methylation and demethylation in adipogenesis and obesity.
Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARγ targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and storage. Among such modification enzymes are histone lysine methyltransferases, which play important roles in transcriptional regulation. Histone methyltransferases are involved in PPARγ gene expression and subsequent adipogenesis. In addition, recent studies revealed that demethylation of histone H3 at lys9 is associated with resistance to obesity. We here review the role of histone methylation and demethylation in adipogenesis, metabolism and obesity.
Okamura
Masashi
M
Division of metabolic medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Inagaki
Takeshi
T
Tanaka
Toshiya
T
Sakai
Juro
J
D050156:Adipogenesis / Q000235:genetics / Q000502:physiology*; D000818:Animals; D019175:DNA Methylation; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D047495:PPAR gamma / Q000096:biosynthesis / Q000235:genetics
D006657:Histones; D047495:PPAR gamma; D011495:Histone-Lysine N-Methyltransferase