title: [Correlation between sleep apnea hypopnea syndrome and preeclampsia and the possible pathogenesis of preeclampsia].
abstract: OBJECTIVE
  To investigate the relationship between sleep apnea-hypopnea syndrome (SAHS) and preeclampsia and the possible pathogenesis of the latter.
  
  
  METHODS
  Twenty-five healthy pregnant women, 43 pregnant women with preeclampsia, and 27 with preeclampsia complicated by SAHS were enrolled in this study. Apnea-hypopnea index (AHI) and the lowest arterial oxygen saturation (LSaO2) were measured through a 7-hour polysomnography (PSG), and the maternal age, gestational age, body mass index and 24-hour urine protein were recorded.
  
  
  RESULTS
  All the indexes except for the maternal age and gestational age showed significant differences between the 3 groups. The two groups of preeclampsia patients showed a significant difference in BMI from the control cases. Significant positive correlations of AHI to BMI, MAP and 24-hour urine protein were noted; LSaO2 was found to inversely correlate to BMI, MAP, and 24-hour urine protein. In spite of the significant correlation of BMI to the other indexes, we found that BMI was less important than AHI and LSaO2.
  
  
  CONCLUSIONS
  SAHS may induce or aggravate preeclampsia. Greater attention should be given to the presence of SAHS in pregnant women with obesity, but obesity is not the predominant predisposing factor for preeclampsia.
authors.affiliation: Department of Sleep Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yehong20078328@126.com
authors.forename: Hong
authors.initials: H
authors.lastname: Ye
authors.forename: Tao-ping
authors.initials: TP
authors.lastname: Li
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Xu
authors.forename: Dun-jin
authors.initials: DJ
authors.lastname: Chen
authors.forename: Hui-shu
authors.initials: HS
authors.lastname: Liu
authors.forename: Chun-huan
authors.initials: CH
authors.lastname: Gao
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Liu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D017286:Polysomnography; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology*; D011247:Pregnancy; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012913:Snoring / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha