Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.
Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.
Wu
Hope H
HH
Department of Pathology, New York University School of Medicine, New York, NY, USA.
Zafar
Samiah
S
Huan
Youming
Y
Yee
Herman
H
Chiriboga
Luis
L
Wang
Beverly Y
BY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology*; D015854:Up-Regulation; D055815:Young Adult
D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin