[Case of neuralgic amyotrophy with anti GT1a antibody].
A 48-year-old-man had intense pain in the neck and muscle weakness in the left upper limb after he presented low grade fever and appetite loss for a week. Several days later, he developed intense pain and severe muscle weakness in bilateral upper limbs. Laboratory examination showed elevated liver enzyme levels. His muscle weakness was severe in the right upper limb and was moderate in the left upper limb. Deep tendon reflexes were decreased in the bilateral upper limbs. CSF showed albuminocytologic dissiciation. A diagnosis of neuralgic amyotrophy was made. His liver dysfunction improved gradually. IgM and IgG anti-GT1a antibodies were positive. Future studies are required to elucidate whether anti-GT1a antibody is associated with the primary pathophysiology of neuralgic amyotrophy.
Nomoto
Nobuatsu
N
Division of Neurology, Toho University Ohashi Medical Center.
Konno
Shingo
S
Murata
Mayumi
M
Nakazora
Hiroshi
H
Nemoto
Hiroshi
H
Fujioka
Toshiki
T
D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D020968:Brachial Plexus Neuritis / Q000175:diagnosis*; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male
D001323:Autoantibodies; D015415:Biomarkers; D005732:Gangliosides; D007074:Immunoglobulin G; C084318:GT1aalpha ganglioside