Relationship between portal chronic inflammation and disease severity in paediatric non-alcoholic fatty liver disease.
BACKGROUND
The non-alcoholic steato-hepatitis Clinical Research Network has recently shown that portal chronic inflammation is associated with liver fibrosis in American children with non-alcoholic fatty liver disease.


OBJECTIVE
We tested whether the portal chronic inflammation-fibrosis association was present in a series of Italian children with non-alcoholic fatty liver disease.


METHODS
We re-assessed the liver biopsies of 144 consecutive Italian children with non-alcoholic fatty liver disease aged 3-18 years and followed at the "Bambino Gesù" Paediatric Hospital. Non-alcoholic fatty liver disease and portal chronic inflammation were diagnosed using the non-alcoholic steato-hepatitis Clinical Research Network criteria. Anthropometry, body composition, liver enzymes, metabolic parameters and blood pressure were measured in all children.


RESULTS
Two children had no portal chronic inflammation, 84 had mild and 58 more than mild portal chronic inflammation according to the non-alcoholic steato-hepatitis Clinical Research Network criteria. Children with no or mild portal chronic inflammation had the same clinical features of those with more than mild portal chronic inflammation except for insulin resistance, which was greater. There was no association between steatosis, lobular inflammation, ballooning, fibrosis and portal chronic inflammation.


CONCLUSIONS
We were not able to confirm the existence of a clinico-pathological association between portal chronic inflammation and disease severity in a series of Italian children with non-alcoholic fatty liver disease. Some clinico-pathological correlates of paediatric non-alcoholic fatty liver disease may be population-specific.
Alisi
Anna
A
Liver Unit, Pediatric Hospital Bambino Gesù, IRCCS, Rome, Italy.
Bedogni
Giorgio
G
De Vito
Rita
R
Comparcola
Donatella
D
Manco
Melania
M
Nobili
Valerio
V
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D018450:Disease Progression; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007558:Italy; D008103:Liver Cirrhosis / Q000473:pathology*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D011169:Portal Vein / Q000473:pathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index