title: Apparent diffusion and fractional anisotropy of diffuse intrinsic brain stem gliomas.
abstract: OBJECTIVE
  DIBSGs have the worst prognosis among pediatric brain tumors with no improvement of outcome for several decades. In this study, we determined whether diffusion imaging could improve patient stratification and our understanding of the impact of therapies.
  
  
  METHODS
  Nine baseline and 24 follow-up DTI studies performed in 9 patients on a 1.5T clinical MR imaging scanner were reviewed. ADC and FA were measured for the whole lesion and at 5 anatomic levels: the rostral medulla, caudal pons, midpons, rostral pons, and caudal midbrain. Reference data were obtained from 8 controls with normal brain stem, 6 patients with medulloblastoma, and 7 patients with pilocytic astrocytoma.
  
  
  RESULTS
  ADC was higher in untreated DIBSG than in normal brain stem and medulloblastoma (1.14 ± 0.18 [×10⁻³ mm²/s] versus 0.75 ± 0.06 and 0.56 ± 0.05, both P < .001). FA was lower in DIBSG than in normal brain stem (0.24 ± 0.04 versus 0.43 ± 0.02, P < .001) but was higher than that in pilocytic astrocytoma (0.17 ± 0.05, P < .05). Lower baseline ADC and higher FA correlated with a worse clinical course. Correlations were more significant at the caudal midbrain than in other regions. ADC decreased and FA increased after RT. Changes of FA after RT at the caudal midbrain correlated with event-free survival.
  
  
  CONCLUSIONS
  Baseline ADC and FA of DIBSG revealed hypocellular tumors with extensive edema. Diffusion changes after therapy implied reduced edema but did not support a significant response to therapy. The significance of diffusion properties varied with anatomic locations, the caudal midbrain being particularly important.
authors.affiliation: Department of Radiology, Childrens Hospital Los Angeles, California 90027, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Panigrahy
authors.forename: G
authors.initials: G
authors.lastname: Dhall
authors.forename: J L
authors.initials: JL
authors.lastname: Finlay
authors.forename: M D
authors.initials: MD
authors.lastname: Nelson
authors.forename: S
authors.initials: S
authors.lastname: Blüml
mesh_terms: D016880:Anisotropy; D001254:Astrocytoma / Q000473:pathology*; D020295:Brain Stem Neoplasms / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D008527:Medulloblastoma / Q000473:pathology*; D008636:Mesencephalon / Q000473:pathology; D011149:Pons / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis