Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.
Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with (213)Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. (213)Bi-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.
Bryan
Ruth A
RA
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Jiang
Zewei
Z
Howell
Robertha C
RC
Morgenstern
Alfred
A
Bruchertseifer
Frank
F
Casadevall
Arturo
A
Dadachova
Ekaterina
E
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000908:Antibodies, Fungal / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001729:Bismuth / Q000627:therapeutic use; D001921:Brain / Q000382:microbiology; D015169:Colony Count, Microbial; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000382:microbiology; D051379:Mice; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use; D016896:Treatment Outcome
D000908:Antibodies, Fungal; D000935:Antifungal Agents; D011868:Radioisotopes; D000666:Amphotericin B; D001729:Bismuth