Serum and cerebrospinal fluid levels of colistin in pediatric patients.
Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 1 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 microg/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 microg/ml but increased in the presence of meningitis (approximately 0.5 microg/ml or 34 to 67% of serum levels).
Antachopoulos
Charalampos
C
3rd Department of Pediatrics, Aristotle University, Thessaloniki, Greece.
Karvanen
Matti
M
Iosifidis
Elias
E
Jansson
Britt
B
Plachouras
Diamantis
D
Cars
Otto
O
Roilides
Emmanuel
E
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003091:Colistin / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D003091:Colistin