title: Gadolinium chloride augments tumor-specific imaging of targeted quantum dots in vivo.
abstract: Nonspecific sequestration of nanoparticles by the reticulo-endothelial system (RES) results in the degradation of image quality of nanoparticle-based imaging. We demonstrate that gadolinium chloride (GdCl3) pretreatment inactivates RES macrophages, thereby increasing circulatory time and amplifying the tumor-specific signal of conjugated nanoparticles in vivo. The experimental results were validated using compartmental modeling, and the rate parameters for the observed kinetics pattern were estimated. This pretreatment strategy could have broad applicability across biomedical applications utilizing theranostic nanoparticles that are sequestered by the RES.
authors.affiliation: Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Parmeswaran
authors.initials: P
authors.lastname: Diagaradjane
authors.forename: Amit
authors.initials: A
authors.lastname: Deorukhkar
authors.forename: Juri G
authors.initials: JG
authors.lastname: Gelovani
authors.forename: Dipen M
authors.initials: DM
authors.lastname: Maru
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000378:metabolism; D005682:Gadolinium / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008954:Models, Biological; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000378:metabolism / Q000493:pharmacokinetics; D009369:Neoplasms / Q000378:metabolism*; D045663:Quantum Dots; D015203:Reproducibility of Results
chemical_list: D015335:Molecular Probes; D005682:Gadolinium; D066246:ErbB Receptors; C038958:gadolinium chloride