Functionalization of peptides and proteins by Mukaiyama aldol reaction.
The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.
Alam
Jenefer
J
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Keller
Thomas H
TH
Loh
Teck-Peng
TP
D000447:Aldehydes / Q000737:chemistry*; D002853:Chromatography, Liquid; D007700:Kinetics; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000447:Aldehydes; D010455:Peptides; D011506:Proteins; C116609:3-hydroxybutanal