title: Erythrocyte catalase and carbonic anhydrase activities in acute leukemias.
abstract: OBJECTIVE
  To determine activity of catalase (CAT) as a antioxidant and carbonic anhydrase (CA) in erythrocytes from acute leukemia cases.
  
  
  METHODS
  Subjects were recruited from patients attending the outpatient clinics or hospitalised in the ward of the Hematology Department of Yuzuncu Yil University Hospital. Venous blood samples were taken from a total of 67 individuals (31 with acute leukemia and 36 healthy) included in the study. CAT enzyme activity was determined in erythrocytes using Aebi's method and CA by hydration of CO2.
  
  
  RESULTS
  CAT activity was found to be significantly decreased (P<0.001) on average in acute leukemia cases as compared to the control group while erythrocyte CA activity was significantly increased (P<0.001).
  
  
  CONCLUSIONS
  Our findings point to malfunction of the antioxidant system in acute leukemia patients. Hence we need to investigation the cause and also its possible contribution to prognosis. Furthermore, clarification of the relationship between the antioxidant system and CA inhibitors in the pathogenesis of acute leukemia appears warranted.
authors.affiliation: Department of Hematology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey. drcengizdemir@hotmail.com
authors.forename: Cengiz
authors.initials: C
authors.lastname: Demir
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: Ramazan
authors.initials: R
authors.lastname: Esen
authors.forename: Murat
authors.initials: M
authors.lastname: Atmaca
authors.forename: Eyüp
authors.initials: E
authors.lastname: Tagdemir
mesh_terms: D000208:Acute Disease; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000097:blood*; D002374:Catalase / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000201:enzymology*; D008297:Male
chemical_list: D000975:Antioxidants; D002374:Catalase; D002256:Carbonic Anhydrases