title: An unusual case of acute myeloid leukemia: late isolated testicular relapse followed by isolated central nervous system relapse.
abstract: Testicular relapse of acute myeloid leukemia without bone marrow involvement is a rare event. We describe a case of an 18-year-old male who had an isolated testicular relapse 86 months (7.2 years) from original diagnosis. He was treated with surgery only, without adjuvant therapy. The patient then developed central nervous system involvement 9 months later. Fluorescence in situ hybridization and immunohistochemistry were used to establish the diagnosis of a relapse rather than a new leukemic process. He was treated with intrathecal chemotherapy and systemic reinduction, followed by a stem cell transplant. This patient had a 7.2-year period between original diagnosis and the testicular relapse of acute myeloid leukemia.
authors.affiliation: Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. dgrier@wfubmc.edu
authors.forename: David D
authors.initials: DD
authors.lastname: Grier
authors.forename: Andrew
authors.initials: A
authors.lastname: Eskew
authors.forename: Thomas
authors.initials: T
authors.lastname: White
authors.forename: Thomas W
authors.initials: TW
authors.lastname: McLean
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D002648:Child; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D007278:Injections, Spinal; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D013866:Thioguanine / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D003561:Cytarabine; D013866:Thioguanine; D003630:Daunorubicin