Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum.
Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC(50) of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.
Fatmawati
Sri
S
Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan, 812-8581, Japan.
Shimizu
Kuniyoshi
K
Kondo
Ryuichiro
R
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D015394:Molecular Structure; D020940:Reishi / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D014315:Triterpenes; C556862:ganoderic acid; D000449:Aldehyde Reductase