Reducing hippocampal cell proliferation in the adult rat does not prevent the acquisition of cocaine-induced conditioned place preference.
Neurogenesis is important for developing certain forms of memory. Recently, hippocampal cell proliferation has been implicated in the development of drug addiction, an extreme form of emotional/motivational pathological memory. Aiming to explore the role of hippocampal neural cell proliferation in cocaine-induced conditioned place preference (CPP), we treated rats with whole brain X-irradiation, which substantially decreases the number of progenitor cells in the subventricular zone of the lateral ventricles and subgranular zone of the dentate gyrus. Surprisingly, there was no difference in the expression of cocaine-induced CPP. These results suggest that the existing neural network, rather than potential new neural circuits mediated by adult neurogenesis, is sufficient for the acquisition of cocaine-induced CPP.
Brown
Travis E
TE
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA. Travis_Brown@brown.edu
Lee
Brian R
BR
Ryu
Vitaly
V
Herzog
Thiebaut
T
Czaja
Krzysztof
K
Dong
Yan
Y
D053687:Adult Stem Cells / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D049109:Cell Proliferation / Q000187:drug effects* / Q000528:radiation effects; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014965:X-Rays / Q000009:adverse effects
D018765:Dopamine Uptake Inhibitors; D001973:Bromodeoxyuridine; D003042:Cocaine