Novel heteronuclear ruthenium-copper coordination compounds as efficient DNA-cleaving agents.
The DNA-cleavage ability of novel bifunctional heterobimetallic copper-ruthenium complexes is demonstrated by using gel electrophoresis.
van der Steen
Stefanie
S
Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.
de Hoog
Paul
P
van der Schilden
Karlijn
K
Gamez
Patrick
P
Pitié
Marguerite
M
Kiss
Robert
R
Reedijk
Jan
J
D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000187:drug effects*; D053837:DNA Cleavage; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*
D009942:Organometallic Compounds; D003300:Copper; D012428:Ruthenium; D004247:DNA