title: The Design and Synthesis of Highly Branched and Spherically Symmetric Fluorinated Macrocyclic Chelators.
abstract: Two novel, highly fluorinated macrocyclic chelators with highly branched and spherically symmetric fluorocarbon moieties have been designed and efficiently synthesized. This is achieved by conjugating a spherically symmetric fluorocarbon moiety to the macrocyclic chelator DOTA, with or without a flexible oligo-oxyethylene linker between these two parts. As a result of the spherical symmetry, all 27 fluorine atoms in each fluorinated chelator give a sharp singlet (19)F NMR signal. The hydrophilicity and the (19)F relaxation behavior of fluorinated chelators can be modulated by the insertion of a flexible linker between the fluorocarbon moiety and the macrocyclic linker. These chelators serve as prototypes for (1)H-(19)F dual-nuclei magnetic resonance imaging agents.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, U. S. A.
authors.forename: Zhong-Xing
authors.initials: ZX
authors.lastname: Jiang
authors.forename: Y Bruce
authors.initials: YB
authors.lastname: Yu