title: Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms.
abstract: Over the last decade, Lipid NanoCapsules (LNCs) have been intensively used as effective drug delivery systems; they are classically prepared using a phase-inversion method. Following formulation of the LNCs, the molecular insertion of commercially-available disteraoylphosphatidylethanolamine-peg amphiphiles is performed into the LNC shell, using a post-insertion method, more classically applied with liposomes. The subsequent LNC interfacial modifications are investigated by using size and electrokinetic measurements. More particularly, the length and the nature of the hydrophilic part of the post-inserted surfactant are modified. The results are discussed in order to improve our understanding of post-insertion mechanisms.
authors.affiliation: Inserm U646, Ingénierie de la vectorisation particulaire, Université d'Angers, 49100 Angers, France. thomas.perrier2@hotmail.fr
authors.forename: Thomas
authors.initials: T
authors.lastname: Perrier
authors.forename: Patrick
authors.initials: P
authors.lastname: Saulnier
authors.forename: Florian
authors.initials: F
authors.lastname: Fouchet
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Lautram
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Benoît
mesh_terms: D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D024202:Electrophoretic Mobility Shift Assay; D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D053769:Nanocapsules; D036103:Nanotechnology; D010316:Particle Size; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013997:Time Factors; D014280:Triglycerides / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008055:Lipids; D053769:Nanocapsules; D010714:Phosphatidylethanolamines; D013229:Stearic Acids; D013501:Surface-Active Agents; D014280:Triglycerides; C542236:labrafac WL 1349; C107570:polyethylene glycol-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols; C067028:Solutol HS 15