title: Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease.
abstract: Apolipoprotein C-I (apoCI) is implicated in lipid metabolism and inflammatory response, both important risk factors for human heart disease. However, most findings come from in vitro or animal studies, whereas data on human apoCI are sparse. To elucidate the role of apoCI in human disease, we analyzed a functional polymorphism in the promoter region of the apoCI gene in relation to blood lipids, C-reactive protein (CRP), coronary artery disease (CAD), and myocardial infarction (MI). Rs11568822 is a 4-base pair insertion/deletion (Ins/Del) polymorphism, and the Ins allele leads to a higher transcription in vitro compared with the Del allele. This polymorphism was analyzed in the Intergene study, a case-control study for CAD (N = 1236), and the Stockholm Heart Epidemiology Program, a case-control study for MI (N = 2774). Subjects homozygous for the Ins genotype had significantly higher serum levels of triglycerides (P = .01 and P = .006) and lower serum levels of CRP (P = .02 and P < .0001) compared with all other subjects in both studies. Similar results were obtained when analyzing only the controls of both studies (P = .002 and P = .0002, triglycerides; P = .002 and P < .0001, CRP). However, apoCI was not associated with CAD or MI. In conclusion, our data show that apoCI genotype is associated with serum levels of triglycerides and CRP, confirming the role of apoCI in lipid metabolism and suggesting that it also influences inflammation.
authors.affiliation: Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, 41345 Gothenburg, Sweden. bob.olsson@medic.gu.se
authors.forename: Bob
authors.initials: B
authors.lastname: Olsson
authors.forename: Bruna
authors.initials: B
authors.lastname: Gigante
authors.forename: Kirsten
authors.initials: K
authors.lastname: Mehlig
authors.forename: Alicia
authors.initials: A
authors.lastname: Bergsten
authors.forename: Karin
authors.initials: K
authors.lastname: Leander
authors.forename: Ulf
authors.initials: U
authors.lastname: de Faire
authors.forename: Lauren
authors.initials: L
authors.lastname: Lissner
authors.forename: Dag S
authors.initials: DS
authors.lastname: Thelle
authors.forename: Lena M S
authors.initials: LM
authors.lastname: Carlsson
mesh_terms: D000483:Alleles; D053302:Apolipoprotein C-I / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014280:Triglycerides / Q000097:blood*
chemical_list: D053302:Apolipoprotein C-I; D014280:Triglycerides; D002097:C-Reactive Protein