title: [Variability of the exogenic antioxidant effect on survival: modeling in Drosophila lines with different lifespan and l(2)gl-tumor suppressor dosage].
abstract: Different exogenic antioxidants and geroprotectors are used to decrease age abnormalities and enhance the human life span. However, the antioxidant effect on lifespan is variable and requires detailed analysis. In the present report, we modeled in Drosophila the peculiar character of action of various doses of a new phenol antioxidant TC-13. We studied the TC-13 effect on aging of two Drosophila lines with genetically determined contrast lifespan dynamics. In addition, we tested the TC-13 antioxidant influence on the background of heterozygozity on the loss-of-function mutation of the l(2)gl tumor suppressor. The differing effect of TS-13 on LS, the character of which depends on the antioxidant dosage, genotype of line, and sex of Drosophila, was found. TS-13 in the concentration 0.2% did not affect the lifespan in all studied lines and decreased survival, whereas the antioxidant in a concentration of 1% positively affected the lifespan in both males and females of long-living lines. The antioxidant effect on animal lines with a smaller dose of tumor suppressor l(2)gl resulted in a decrease of the lifespan.
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Vaĭsman
authors.forename: M D
authors.initials: MD
authors.lastname: Golubovskiĭ
authors.forename: N K
authors.initials: NK
authors.lastname: Zenkov
authors.forename: E B
authors.initials: EB
authors.lastname: Men'shchikova
authors.forename: V N
authors.initials: VN
authors.lastname: Pashin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D005260:Female; D018628:Gene Dosage; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D008297:Male; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D012727:Sex Characteristics; D013886:Thiosulfonic Acids / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C551700:3-(3'-tert-butyl-4'-hydroxyphenyl) propythiosulfonate; D000975:Antioxidants; D029721:Drosophila Proteins; D010636:Phenols; D013886:Thiosulfonic Acids; D025521:Tumor Suppressor Proteins; C081435:l(2)gl protein, Drosophila