Feeding and bone.
Diurnal variation in bone turnover is responsive to feeding and fasting, and feeding results in an acute decrease in bone resorption. These responses may be governed by multiple intermediary systems, and investigation of these systems has led to new potential therapeutic agents for osteoporosis. Here we review the current understanding of the mediators of bone turnover response to feeding, including calcitropic hormones, cortisol, gut peptides and pancreatic peptides. We also discuss the results of clinical trials of analogues of ghrelin, amylin and GLP-2 in the treatment of low bone density, and the potential bone effects of GLP-1 mimetics that are used in the treatment of type 2 diabetes.
Walsh
Jennifer S
JS
Centre for Biomedical Research, Northern General Hospital, Sheffield S5 7AU, UK. jennifer.walsh2@sth.nhs.uk
Henriksen
Dennis B
DB
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D010024:Osteoporosis / Q000378:metabolism / Q000628:therapy; D017476:Receptors, Neuropeptide Y / Q000378:metabolism
D006728:Hormones; D017476:Receptors, Neuropeptide Y