What the mitochondria see.
High-Ca(2+) microdomains at ER-mitochondrial junctions have been presumed to exist. Csordás et al. (2010) and Giacomello et al. (2010) report the Ca(2+) dynamics at the outer mitochondrial membrane surface in response to IP(3)-mediated Ca(2+) release and store-mediated Ca(2+) influx with several expected and some unexpected findings.
Shin
Dong Min
DM
Department of Oral Biology, Yonsei University College of Dentistry, Seoul 120-752, Korea.
Muallem
Shmuel
S