No association of IL-10 promoter SNP -592 and -1082 and SIDS.
Sudden infant death syndrome (SIDS) constitutes a considerable percentage of infant death of unknown etiology. The genetically controlled pathway of cytokine mediated response to inflammation is presumed to play a role in SIDS. The A allele of SNP -592 of the promoter region of the anti-inflammatory cytokine IL-10 has been suggested to be associated with SIDS. Herein we investigated whether we could confirm this finding by SNP genotyping a series of 123 cases of SIDS and 406 control cases. We did not find a correlation between the A allele or an A allele containing genotype of IL-10 promoter SNP -592 and SIDS which is in contrast to previous studies. Also, in concordance with previous work, no association of the A allele or A allele containing genotypes of IL-10 promoter SNP -1082 and SIDS was found.
Courts
Cornelius
C
Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, D-53111 Bonn, Germany. cornelius.courts@uni-bonn.de
Madea
Burkhard
B
D000483:Alleles; D016022:Case-Control Studies; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013398:Sudden Infant Death / Q000235:genetics* / Q000276:immunology*
D016753:Interleukin-10