Synthesis of polyhalo acridones as pH-sensitive fluorescence probes.
Polyhalo isophthalonitriles were reacted with substituted anilines and subsequently cyclocondensed in the presence of sulfuric acid to give polyhalo acridones. These polyhalo acridones were proven to be useful as pH-sensitive fluorescent probes for a wide range of acidic and basic conditions.
Huang
Chao
C
Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Yan
Sheng-Jiao
SJ
Li
Yan-Mei
YM
Huang
Rong
R
Lin
Jun
J
D054831:Acridones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D013464:Sulfuric Acids / Q000737:chemistry
D054831:Acridones; D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D013464:Sulfuric Acids; C033158:sulfuric acid