Cerebral sinus venous thrombosis in Swiss children.
AIMo describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) in Switzerland.


METHODS
data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow-up examination and a cognitive assessment were performed (mean follow-up period 26mo). Differences between neonates and children (patients older than 28d) were assessed and predictors of outcome were determined.


RESULTS
twenty-one neonates (14 males, seven females; mean age 9d, SD 8d) and 44 children (30 males, 14 females; mean age 8y 7mo, SD 4y 5mo) were reported. The incidence of paediatric CSVT in Switzerland was 0.558 per 100000 per year. In neonates, the deep venous system was more often involved and parenchymal injuries were more common. The strongest predictor of poor outcome was neonatal age (odds ratio 17.8, 95% confidence interval 0.847-372.353). Most children showed global cognitive abilities within the normal range, but impairments in single cognitive subdomains were frequent.


CONCLUSIONS
paediatric CSVT is rare. Its outcome is poor in neonates. Most children have good neurological outcomes, but some patients have individual neuropsychological impairments.
Grunt
Sebastian
S
Department of Neuropaediatrics, University Children's Hospital, Inselspital, Berne, Switzerland.
Wingeier
Kevin
K
Wehrli
Edith
E
Boltshauser
Eugen
E
Capone
Andrea
A
Fluss
Joel
J
Gubser-Mercati
Danielle
D
Jeannet
Pierre-Yves
PY
Keller
Elmar
E
Marcoz
Jean-Pierre
JP
Schmitt-Mechelke
Thomas
T
Weber
Peter
P
Weissert
Markus
M
Steinlin
Maja
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D002658:Developmental Disabilities / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D013557:Switzerland / Q000453:epidemiology