Luteal phase progesterone increases live birth rate after frozen embryo transfer.
OBJECTIVE
To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles.


METHODS
Prospective randomized controlled trial.


METHODS
University-based hospital.


METHODS
Four hundred thirty-five women undergoing embryo transfer in natural cycles.


METHODS
The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support.


METHODS
Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate.


RESULTS
Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate.


CONCLUSIONS
Progesterone supplementation improves live birth rate after embryo transfer in natural cycles.
Bjuresten
Kerstin
K
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Landgren
Britt-Marie
BM
Hovatta
Outi
O
Stavreus-Evers
Anneli
A
D000328:Adult; D000465:Algorithms; D004334:Drug Administration Schedule; D004624:Embryo Transfer / Q000379:methods* / Q000706:statistics & numerical data; D004622:Embryo, Mammalian; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology; D005615:Freezing; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D008183:Luteal Phase / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D005300:Fertility Agents, Female; D011374:Progesterone