[From conventional cytogenetics to microarrays. Fifty years of Philadelphia chromosome].
In 1960 Ph-chromosome was found associated with the presence of chronic myelogenous leukemia. In these 50 years an increasing number of cytogenetic abnormalities have been found associated with hematological malignancies. The presence of these abnormalities is not only important for the diagnosis of the patient, but it also contributes to the prognosis of patients with leukemia or lymphoma. For this reason the WHO classification of hematological disease has included these studies for the correct characterization of leukemias and lymphomas. In addition, the use of FISH and micromatrix methodologies have refined the genetic lesions present in these malignancies. The cytogenetic changes observed also provide further information in relation to the therapy.
Hernández
Jesús M
JM
Servicio de Hematología, Hospital Universitario de Salamanca y Unidad de Diagnóstico Molecular y Celular del Cáncer, Instituto de Biología Molecular y Celular del Cáncer (IBMCC), Centro de Investigación del Cáncer, Universidad de Salamanca, Salamanca, España. jmhr@usal.es
Granada
Isabel
I
Solé
Francesc
F
D000782:Aneuploidy; D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure; D055028:Comparative Genomic Hybridization; D003582:Cytogenetics / Q000379:methods* / Q000639:trends; D016044:Fusion Proteins, bcr-abl / Q000032:analysis / Q000235:genetics; D019337:Hematologic Neoplasms / Q000145:classification / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping / Q000379:methods; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000235:genetics / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D014944:World Health Organization
D014408:Biomarkers, Tumor; D016044:Fusion Proteins, bcr-abl