title: Diagnostic modalities for gastro-esophageal reflux in infantile wheezers.
abstract: OBJECTIVE
  To compare the diagnostic value of Gastro-intestinal (GI) scintiscan with 24-h pH study in detecting gastro-esophageal reflux (GER) among infantile wheezers.
  
  
  METHODS
  Fifty-two children < 2 years of age.
  
  
  METHODS
  All patients, irrespective of symptom underwent study to evaluate for GER.
  
  
  RESULTS
  GER studies were positive in almost 45% of cases. The agreement between positivity of these two tests is best among children between 7 and 12 months of age (κ = 0.591, p = 0.002). Overall GI scintiscan was a better test with higher sensitivity and specificity as compared to 24-h pH study when compared with the history suggestive of reflux and clinical response with anti-reflux treatment as standard (p ≤ .001).
  
  
  CONCLUSIONS
  Both GER scan and 24-h pH study are complimentary to each other, however, if both the tests are available then GI scintiscan is better as a single test for GER in these early wheezers.
authors.affiliation: Department of Pediatrics, Lady Hardinge Medical College & Kalawati Saran Children's Hospital, New Delhi, India. dr_soumyapatra@rediffmail.com
authors.forename: Soumya
authors.initials: S
authors.lastname: Patra
authors.forename: Varinder
authors.initials: V
authors.lastname: Singh
authors.forename: Jagdish
authors.initials: J
authors.lastname: Chandra
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
authors.forename: Madhvi
authors.initials: M
authors.lastname: Tripathi
mesh_terms: D002675:Child, Preschool; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012135:Respiratory Sounds / Q000175:diagnosis / Q000209:etiology*; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid