title: The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease.
abstract: BACKGROUND
  Previous separate studies have shown associations of coronary artery disease (CAD) with acid phosphatase locus 1 (ACP1) and adenosine deaminase locus 1 (ADA1) genetic polymorphisms. Because it is known that the 2 systems interact and have important immunologic and metabolic functions, these 2 genes were both examined in the same sets of subjects.
  
  
  METHODS
  Two-hundred forty subjects with CAD, 156 subjects with cardiovascular diseases without CAD, 279 subjects with Non Insulin Dependent Diabetes Mellitus (NIDDM) without CAD and 771 consecutive healthy newborn infants have been studied.
  
  
  RESULTS
  The association of ACP1 and ADA1 with CAD depends on sex and diabetes. In particular, the association between ADA1 and CAD is present in nondiabetic subjects only, and it is dependent on sex (males), whereas the association of CAD with ACP1 is present in diabetic subjects only, and it is dependent on sex (females).
  
  
  CONCLUSIONS
  The fact that the association of ACP1 with CAD is evident only in diabetic subjects, whereas the association of ADA1 with CAD is evident only in nondiabetic subjects suggests an heterogeneity in the pathogenetic mechanisms leading to CAD. In addition, the association with sex that could be based on hormonal differences is in favor of heterogenity.
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy. gloria@med.uniroma2.it
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gloria-Bottini
authors.forename: Maria
authors.initials: M
authors.lastname: Banci
authors.forename: Patrizia
authors.initials: P
authors.lastname: Saccucci
authors.forename: Federica
authors.initials: F
authors.lastname: Papetti
authors.forename: Anna
authors.initials: A
authors.lastname: Neri
authors.forename: Antonio
authors.initials: A
authors.lastname: Pietroiusti
authors.forename: Andrea
authors.initials: A
authors.lastname: Magrini
authors.forename: Egidio
authors.initials: E
authors.lastname: Bottini
mesh_terms: D000243:Adenosine Deaminase / Q000235:genetics*; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012737:Sex Factors
chemical_list: D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases; D000243:Adenosine Deaminase