[Cell renovation in the intestinal epithelium in aging].
The ability to cell renovation of two basic cell types of intestinal mucosa is the important mechanism for the regulation and support of the gut physiological functions in aging and under the influence of the ecological negative factors. The study of the processes of cell renovation of the intestinal epithelial and neuroendocrine cells in physiological and radiological aging has a great interest, because the irradiation in the subletal doses could be considered as the model of artificial aging, and this fact enables studying of the radiological influence as the ecological factor, promoting the aging. In this study, the increase of cell proliferation in intestinal mucosa in physiological as well as artificial aging was observed. It was shown, that the total population of mitotic cells increases two times. These data testify about active participation of the mechanisms of cell renovation in the safety of gut functions during aging.
Gusel'nikova
E A
EA
Konovalov
S S
SS
Poliakova
V O
VO
Kvetnoĭ
I M
IM
D000375:Aging / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D019588:Aging, Premature / Q000209:etiology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D049109:Cell Proliferation / Q000528:radiation effects; D053379:Chromogranin A / Q000096:biosynthesis; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D055099:Neuroendocrine Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D015415:Biomarkers; D053379:Chromogranin A; D019394:Ki-67 Antigen