Conjugated oligoelectrolyte harnessed polyhedral oligomeric silsesquioxane as light-up hybrid nanodot for two-photon fluorescence imaging of cellular nucleus.
A water-soluble organic/inorganic hybrid nanodot based on polyhedral oligomeric silsesquioxane (POSS) and conjugated oligoelectrolyte is designed and synthesized for two-photon fluorescence imaging of cellular nucleus, which takes advantage of its small size (∼3.3 nm) that imparts nucleus permeability and substantial DNA-enhanced two-photon excited fluorescence that allows illuminating the nucleus with a high contrast.
Pu
Kan-Yi
KY
Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore.
Li
Kai
K
Zhang
Xinhai
X
Liu
Bin
B
D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D006801:Humans; D008856:Microscopy, Fluorescence; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size; D017785:Photons; D045663:Quantum Dots
D004573:Electrolytes; D017646:Organosilicon Compounds; D004247:DNA