Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.
This Letter describes a detailed SAR analysis of the mGluR4 positive allosteric modulator, PHCCC. We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.
Williams
Richard
R
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Zhou
Ya
Y
Niswender
Colleen M
CM
Luo
Qingwei
Q
Conn
P Jeffrey
PJ
Lindsley
Craig W
CW
Hopkins
Corey R
CR