[Brazilian guidelines for the diagnosis of narcolepsy].
This manuscript contains the conclusion of the consensus meeting on the diagnosis of narcolepsy based on the review of Medline publications between 1980-2010. Narcolepsy is a chronic disorder with age at onset between the first and second decade of life. Essential narcolepsy symptoms are cataplexy and excessive sleepiness. Cataplexy is defined as sudden, recurrent and reversible attacks of muscle weakness triggered by emotions. Accessory narcolepsy symptoms are hypnagogic hallucinations, sleep paralysis and nocturnal fragmented sleep. The clinical diagnosis according to the International Classification of Sleep Disorders is the presence of excessive sleepiness and cataplexy. A full in-lab polysomnography followed by a multiple sleep latency test is recommended for the confirmation of the diagnosis and co-morbidities. The presence of two sleep-onset REM period naps in the multiple sleep latency test is diagnostic for cataplexy-free narcolepsy. A positive HLA-DQB1*0602 with lower than 110pg/mL level of hypocretin-1 in the cerebrospinal fluid is required for the final diagnosis of cataplexy- and sleep-onset REM period -free narcolepsy.
Alóe
Flávio
F
Hospital das Clínicas, Universidade de São Paulo, SP, Brasil. piero.ops@terra.com.br
Alves
Rosana Cardoso
RC
Araújo
John F
JF
Azevedo
Alexandre
A
Bacelar
Andrea
A
Bezerra
Márcio
M
Bittencourt
Lia Rita Azeredo
LR
Bustamante
Guilherme
G
Cardoso
Tânia Aparecida Marchiori de Oliveira
TA
Eckeli
Alan L
AL
Fernandes
Regina Maria França
RM
Goulart
Leonardo
L
Pradella-Hallinan
Márcia
M
Hasan
Rosa
R
Sander
Heidi Haueisen
HH
Pinto
Luciano Ribeiro
LR
Lopes
Maria Cecília
MC
Minhoto
Gisele Richter
GR
Moraes
Walter
W
Moreira
Gustavo Antônio
GA
Pachito
Daniela
D
Pedrazolli
Mário
M
Poyares
Dalva
D
Prado
Lucila
L
Rizzo
Geraldo
G
Rodrigues
R Nonato
RN
Roitman
Israel
I
Silva
Ademir Baptista
AB
Tavares
Stella Márcia Azevedo
SM
D001938:Brazil; D003937:Diagnosis, Differential; D006801:Humans; D009290:Narcolepsy / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics