title: [The model of resting forms of mycobacteria for testing of drugs for latent forms of tuberculosis].
abstract: The new model of obtaining of ovoid resting forms Mycobacterium smegmatis, which are morphologically different from vegetative (rod-like) cells, was developed. Ovoid forms were characterized by a drastically decreased level of metabolic activity, an increased stability to heat processing and antibiotics action, and also by prolonged (more than 2 months) storage time preserving colony-forming ability. Obtained resting forms of mycobacteria may be used in test-systems for checking efficiency of new medical agents against latent forms of tuberculosis and determination of role of these of those genes in entering rest state.
authors.forename: A M
authors.initials: AM
authors.lastname: Anuchin
authors.forename: A V
authors.initials: AV
authors.lastname: Goncharenko
authors.forename: I V
authors.initials: IV
authors.lastname: Galon
authors.forename: O I
authors.initials: OI
authors.lastname: Demidenok
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Kudykina
authors.forename: M M
authors.initials: MM
authors.lastname: Moĭsenovich
authors.forename: A L
authors.initials: AL
authors.lastname: Muliukin
authors.forename: A S
authors.initials: AS
authors.lastname: Kaprel'iants
mesh_terms: D000904:Antibiotics, Antitubercular / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D024881:Drug Resistance, Bacterial; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D020102:Mycobacterium smegmatis / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure
chemical_list: D000904:Antibiotics, Antitubercular