title: Pure germinoma of the pineal gland with synchronous spinal dissemination--case report.
abstract: An 11-year-old boy presented with pineal pure germinoma with spinal dissemination manifesting as a 1-month history of ocular motility disturbance and a history of abnormal sensations in the left leg persisting for several months. His past medical history was unremarkable. Craniospinal magnetic resonance imaging showed an enhanced tumor in the pineal gland and widespread leptomeningeal dissemination in the spinal canal. Biopsy of the pineal tumor was performed. Histological examination revealed a pure germinoma. Chemotherapy with carboplatin and etoposide in combination with radiotherapy induced complete remission of the tumors. He regained normal eye movement and sensation in his left leg during the chemotherapy period. Germinomas with dissemination are generally more malignant and refractory than solitary germinomas, but this patient showed a strong response to chemoradiotherapy.
authors.affiliation: Department of Neurosurgery, Koshigaya Hospital Dokkyo University School of Medicine, Koshigaya, Saitama, Japan. nagaishi-nsu@umin.ac.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Nagaishi
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Suzuki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Katumi
authors.initials: K
authors.lastname: Hoya
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Narita
authors.forename: Aya
authors.initials: A
authors.lastname: Shinomiya
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shibui
authors.forename: Akio
authors.initials: A
authors.lastname: Hyodo
mesh_terms: D002648:Child; D018237:Germinoma / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008578:Meninges / Q000473:pathology*; D010870:Pineal Gland / Q000473:pathology*; D016896:Treatment Outcome