title: Correlation of akinesia with graft patency and cardiac enzyme after off-pump coronary artery bypass graft surgery.
abstract: BACKGROUND
  The aim of the present study was to identify the clinical implications of newly developed akinesia in echocardiography after off-pump coronary artery bypass graft (CABG) surgery and its relationship with graft patency.
  
  
  RESULTS
  A total of 512 patients underwent off-pump CABG from January 2007 to November 2008. Two hundred and thirty-nine patients, whose echocardiography and multi-slice computed tomography data were available, were included in the study. Wall motion was subdivided into 16 segments and analyzed. Patients were separated into group A with newly developed akinesia (n=20), and group B without newly developed akinesia (n=219). Morbidity and early mortality, cardiac enzyme level, and graft patency were compared. The incidence of newly developed akinesia according to the anatomical territory was as follows: anterior, 5; lateral, 3; posterior, 7; and multiple territories, 5. Significant differences in preoperative ejection fraction were observed between the 2 groups (group A, 45.0+/-7%; group B, 58.0+/-12.2%, P<0.001). There was no statistical difference in the mean number of bypassed grafts and the complete revascularization rate. Complication and early mortality rates were insignificant between the 2 groups. There was little association between graft patency, cardiac enzyme level, and newly developed akinesia (P>0.05). Multivariate analysis showed that the preoperative ejection fraction was a risk factor for newly developed akinesia.
  
  
  CONCLUSIONS
  The mechanism of development of akinesia after off-pump CABG might be attributable to intraoperative coronary malperfusion, which is probably due to cardiac manipulation rather than graft occlusion.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Yonsei Cardiovascular Hospital, Yonsei University Health System, Yonsei University Medical College, Seoul, South Korea.
authors.forename: Hongseok
authors.initials: H
authors.lastname: Yang
authors.forename: Young-Nam
authors.initials: YN
authors.lastname: Youn
authors.forename: Kyung Jong
authors.initials: KJ
authors.lastname: Yoo
mesh_terms: D000368:Aged; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D004562:Electrocardiography; D004798:Enzymes / Q000032:analysis; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology*; D012307:Risk Factors; D013318:Stroke Volume; D058017:Vascular Grafting / Q000009:adverse effects*; D014654:Vascular Patency
chemical_list: D004798:Enzymes