Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows.
Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd(area), AUC, t(1/2beta), Cl(B), MRT and P/C ratio were 0.50 +/- 0.19 L.kg(-1), 62.2 +/- 23.3 microg.ml(-1).h, 1.02 +/- 0.07 h, 0.30 +/- 0.09 L.kg(-1).h(-1), 1.55 +/- 0.25 h and 0.52 +/- 0.27, respectively, in healthy and 1.55 +/- 0.52 L.kg(-1), 37.0 +/- 17.1 microg.ml(-1).h, 1.56 +/- 0.25 h, 0.56 +/- 0.14 L.kg(-1).h(-1), 2.14 +/- 0.34 h and 1.44 +/- 0.60, respectively, in endometritic cows. The drug was detected in milk for 36 h after administration. For MIC(90) of 0.5 microg.ml(-1) the most appropriate dosage for ceftriaxone, would be 9.0 mg.kg(-1) repeated at 6 h intervals for the treatment of endometritis in cows.
Kumar
Sudershan
S
Division of Animal Reproduction, Gynaecology & Obstetrics, Faculty of Veterinary Sciences & Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences & Technology of Jammu R.S.Pura Campus, Jammu, (J&K)-181102, India. drsudarshandogra@yahoo.com
Srivastava
Anil K
AK
Dumka
V K
VK
Kumar
Naresh
N
Raina
Rajinder K
RK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D019540:Area Under Curve; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002443:Ceftriaxone / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004715:Endometriosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008826:Microbial Sensitivity Tests; D008892:Milk / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone