title: Comparison of the remineralization potential of CPP-ACP and CPP-ACP with 900 ppm fluoride on eroded human enamel: An in situ study.
abstract: OBJECTIVE
  The aim of this in situ study was to compare the remineralization potential of pastes containing CPP-ACP and CPP-ACP with 900 ppm fluoride on human enamel softened by a cola drink.
  
  
  METHODS
  Forty-five enamel specimens obtained from human third molar teeth were eroded in a cola drink for 8 min and then attached to intra-oral devices worn by five volunteers. The specimens were subjected to three different in situ remineralization protocols using: (1) CPP-ACP (Group I), (2) CPP-ACP with 900 ppm fluoride (Group II), and (3) saliva (Group III, control). Vickers microhardness measurements were obtained at baseline followed by demineralization and remineralization stages.
  
  
  RESULTS
  The CPP-ACP, CPP-ACP with 900 ppm fluoride and saliva controls resulted in 46.24%, 64.25% and 2.98% increase in post-erosion microhardness values, respectively. One-way ANOVA revealed statistically significant differences in the mean microhardness values between pastes containing CPP-ACP and CPP-ACP with 900 ppm fluoride.
  
  
  CONCLUSIONS
  Both CPP-ACP and CPP-ACP with 900 ppm fluoride substantially remineralized the softened enamel, with the CPP-ACP and fluoride combination showing higher remineralization potential than CPP-ACP. This study confirmed the synergistic effect of fluoride with CPP-ACP on remineralization of eroded enamel.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Tamilnadu Government Dental College and Hospital, Chennai, Tamilnadu, India.
authors.forename: N
authors.initials: N
authors.lastname: Srinivasan
authors.forename: M
authors.initials: M
authors.lastname: Kavitha
authors.forename: S C
authors.initials: SC
authors.lastname: Loganathan
mesh_terms: D000328:Adult; D002253:Carbonated Beverages / Q000009:adverse effects; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002364:Caseins / Q000008:administration & dosage / Q000627:therapeutic use*; D003743:Dental Enamel / Q000187:drug effects; D004357:Drug Synergism; D004867:Equipment Design; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D006244:Hardness; D006801:Humans; D008297:Male; D012463:Saliva / Q000502:physiology; D013314:Stress, Mechanical; D017001:Tooth Demineralization / Q000517:prevention & control; D014077:Tooth Erosion / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides