The architecture of RNA polymerase fidelity.
The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the ways in which the trigger loop may promote selection of correct nucleotide triphosphate substrates. See research article http://www.biomedcentral.com/1741-7007/8/54.
Kaplan
Craig D
CD
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. cdkaplan@tamu.edu
D001665:Binding Sites / Q000235:genetics / Q000502:physiology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D014158:Transcription, Genetic / Q000502:physiology*
D012321:DNA-Directed RNA Polymerases