Oxytocin as feeding inhibitor: maintaining homeostasis in consummatory behavior.
Initial studies showed that the anorexigenic peptide oxytocin (OT) regulates gastric motility, responds to stomach distention and to elevated osmolality, and blocks consumption of toxic foods. Most recently, it has been proposed to act as a mediator of general and carbohydrate-specific satiety and regulator of body weight. In the current review, we discuss the function of OT as a homeostatic inhibitor of consumption, capable of mitigating multiple aspects of ingestive behavior and energy metabolism.
Olszewski
Pawel K
PK
Minnesota Obesity Center, Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
Klockars
Anica
A
Schiöth
Helgi B
HB
Levine
Allen S
AS
D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000503:physiopathology; D003259:Consummatory Behavior / Q000187:drug effects / Q000502:physiology*; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009765:Obesity / Q000503:physiopathology / Q000517:prevention & control; D010121:Oxytocin / Q000494:pharmacology / Q000502:physiology*
D010121:Oxytocin