title: Abdominal wall infections with in situ mesh.
abstract: BACKGROUND
  Synthetic mesh is used commonly in the repair of abdominal wall hernias. Infection at the surgical site where mesh is present poses a formidable clinical problem.
  
  
  METHODS
  The current surgical literature was reviewed to formulate accepted approaches to the management of hernia repairs with infected mesh.
  
  
  RESULTS
  Prevention of mesh infection is best achieved by judicious use of systemic antibiotics. Topical antibiotics often are used without convincing evidence to support their value. Laparoscopic repairs have lower infection rates than open repairs. Evidence is lacking to support lower rates of infection with mesh of specific composition or with antibacterial agents that coat the mesh. The diagnosis of mesh infection is principally a clinical one. Repairs of infected mesh usually necessitate antibiotics and removal of the foreign material. Clinical judgment is required for attempts at salvaging portions of the mesh. Component separation or biological materials may be used in those circumstances for hernia repair in which large defects are created by removal of the infected synthetic material.
  
  
  CONCLUSIONS
  Prevention of mesh infections remains the best strategy. Clinical judgment is essential in determining the degree of mesh removal. Continued clinical studies are necessary to improve the outcomes of established mesh infection in hernia repairs.
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Collage
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Rosengart
mesh_terms: D034861:Abdominal Wall / Q000382:microbiology* / Q000473:pathology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D013526:Surgical Mesh / Q000009:adverse effects*; D013530:Surgical Wound Infection / Q000382:microbiology* / Q000517:prevention & control / Q000601:surgery / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents