[Physical activity helps to decrease the effect of genetic predisposition on obesity].
Physical activity helps to decrease the effect of genetic predisposition on obesity Genetic differences explain an essential part of individual obesity differences, but physical activity also appears to be associated with obesity. Twin studies have revealed that genetic variation associated with obesity is less common in those with a high than low level. There are also indications that the FTO gene, a candidate gene predisposing to obesity, has an effect on obesity only in those with a low level of physical activity but not in those with a high level. The effect of obesity-predisposing genetic heritage can thus possibly be suppressed by physical activity.
Karri
Silventoinen
S
Helsingin yliopiston kansanterveystieteen laitos, Helsingin yliopisto.
Jaakko
Kaprio
K
D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D020022:Genetic Predisposition to Disease; D006801:Humans; D009043:Motor Activity / Q000235:genetics*; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control*; D011506:Proteins / Q000235:genetics
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human