Comparative study between chitin/polyacrylic acid (PAA) dressing, lipido-colloid absorbent dressing and alginate wound dressing: a pilot study in the treatment of partial-thickness wound.
BACKGROUND
Polyacrylic acid grafted chitin (Chitin-PAA) contains a hydrogel characteristic that makes it more suitable for wound dressing application. In animal models, Chitin-PAA dressing exhibited properties as a promising dressing. Epithelization promotion, rapid reduction of wound size, reduction of inflammatory cell response, and less toxicity had been noted.


OBJECTIVE
Carryout a pilot clinical comparative study of Chitin-PAA dressing, lipido-colloid absorbent dressing, and alginate wound dressing in the treatment of partial-thickness wound.


METHODS
Between June 2006 and March 2007, 36 partial-thickness wounds were randomized into three groups and three different types of dressing were used. Each wound was treated until it was completely healed, and a visual analogue scale was used for the pain evaluation.


RESULTS
The present study shows the visual analogue pain score in the Chitin-PAA group seems to be a bit higher than the Urgocell group but not statistically different. The completely healed day is not significantly different. Three patients in the lipido-colloid absorbent dressing groups had wound infection but eventually healed after treatment.


CONCLUSIONS
There was no statistical difference in terms of visual analogue pain score and healing time between the lipido-colloid absorbent dressing, alginate dressing, and chitin-PAA dressing.
Angspatt
Apichai
A
Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tanvatcharaphan
Puttan
P
Channasanon
Somruethai
S
Tanodekaew
Siriporn
S
Chokrungvaranont
Prayuth
P
Sirimaharaj
Wimol
W
D000180:Acrylic Resins / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000464:Alginates / Q000627:therapeutic use*; D001458:Bandages; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002686:Chitin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010865:Pilot Projects; D016896:Treatment Outcome; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy; D055815:Young Adult
D000180:Acrylic Resins; D000464:Alginates; D001672:Biocompatible Materials; D002686:Chitin; C006903:carbopol 940