title: Linezolid treatment for intracranial abscesses caused by methicillin-resistant Staphylococcus aureus--two case reports.
abstract: Two patients were treated for intracranial infections involving methicillin-resistant Staphylococcus aureus (MRSA). A 30-year-old woman was admitted to our hospital for intracerebral hemorrhage related to arteriovenous malformation. After decompressive craniectomy, the patient developed an epidural abscess. MRSA was isolated from the pus culture. The infection did not improve after intravenous vancomycin (VCM) administration for 15 days. However, after administration of linezolid (LZD) for 14 days, the infection had improved, and the white blood cell count and C-reactive protein values had normalized. A 53-year-old woman had previously undergone 3 operations for craniopharyngioma before the age of 35 years. She was admitted to our hospital with fever and disturbance of consciousness. Magnetic resonance imaging with contrast medium revealed a brain abscess caused by MRSA. After 14 days of intravenous administration of VCM, the infection had not improved and intravenous administration of LZD was initiated. After administration of LZD for 14 days intravenously and 14 days orally, the infection had improved, and the white blood cell count and C-reactive protein values had normalized. VCM is highly effective against MRSA infection, but penetration into the central nervous system (CNS) is poor. LZD has good CNS penetration, so should be considered for secondline antibiotic therapy for VCM-resistant intracranial MRSA infection.
authors.affiliation: Department of Neurosurgery, Toho University Ohashi Medical Center, Tokyo, Japan. bsaitob@med.toho-u.ac.jp
authors.forename: Norihiko
authors.initials: N
authors.lastname: Saito
authors.forename: Kazuya
authors.initials: K
authors.lastname: Aoki
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Sakurai
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ito
authors.forename: Morito
authors.initials: M
authors.lastname: Hayashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hirata
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Sato
authors.forename: Junichi
authors.initials: J
authors.lastname: Harashina
authors.forename: Masaki
authors.initials: M
authors.lastname: Akahata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwabuchi
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D000328:Adult; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology* / Q000601:surgery; D056424:Decompressive Craniectomy / Q000009:adverse effects; D020802:Epidural Abscess / Q000188:drug therapy* / Q000382:microbiology* / Q000601:surgery; D005260:Female; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D008875:Middle Aged; D023303:Oxazolidinones / Q000008:administration & dosage*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000081:Acetamides; D023303:Oxazolidinones; D011500:Protein Synthesis Inhibitors; D000069349:Linezolid