title: Myocardial contrast echocardiography versus single photon emission computed tomography for assessment of hibernating myocardium in ischemic cardiomyopathy: preliminary qualitative and quantitative results.
abstract: BACKGROUND
  Single photon-emission computed tomography (SPECT) is widely used for the assessment of hibernating myocardium (HM). The aim of this study was to test the hypothesis that myocardial contrast echocardiography (MCE), because of its better spatial and temporal resolution, would be superior to SPECT for the detection of HM.
  
  
  METHODS
  Thirty-nine consecutive patients with symptomatic ischemic cardiomyopathy underwent rest and vasodilator SPECT and MCE. Of these, 23 survived to undergo assessment 3 months after revascularization for the recovery of left ventricular (LV) function (spontaneous recovery or dobutamine induced), which is the definition of HM.
  
  
  RESULTS
  Of the 214 dysfunctional segments, 156 segments demonstrated HM in the 23 patients, of whom 16 showed significant improvement in LV function. Logistic regression analysis showed that both qualitative and quantitative MCE were independent predictors for the detection of HM (P < .0001 vs P = .06 for qualitative MCE vs qualitative SPECT, respectively, and P < .01 vs P = .25 for all quantitative myocardial contrast echocardiographic parameters vs quantitative SPECT, respectively). Using clinical and LV functional data, SPECT, and MCE for predicting the recovery of LV function, MCE was the only independent predictor (P = .03).
  
  
  CONCLUSIONS
  MCE was superior to SPECT for the assessment of HM in ischemic cardiomyopathy.
authors.affiliation: Department of Cardiology and Cardiac Research, Northwick Park Hospital, London, United Kingdom.
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Chelliah
authors.forename: Michael
authors.initials: M
authors.lastname: Hickman
authors.forename: Christopher
authors.initials: C
authors.lastname: Kinsey
authors.forename: Leah
authors.initials: L
authors.lastname: Burden
authors.forename: Roxy
authors.initials: R
authors.lastname: Senior
mesh_terms: D000368:Aged; D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis*; D003287:Contrast Media; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D017682:Myocardial Stunning / Q000150:complications / Q000175:diagnosis*; D055420:Perfusion Imaging / Q000379:methods*; D010743:Phospholipids; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride