title: Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.
abstract: A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.
authors.affiliation: Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London, WC1N 1AX, UK.
authors.forename: Silvia
authors.initials: S
authors.lastname: Sparapani
authors.forename: Stefania
authors.initials: S
authors.lastname: Bellini
authors.forename: Mekala
authors.initials: M
authors.lastname: Gunaratnam
authors.forename: Shozeb M
authors.initials: SM
authors.lastname: Haider
authors.forename: Aldo
authors.initials: A
authors.lastname: Andreani
authors.forename: Mirella
authors.initials: M
authors.lastname: Rambaldi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Locatelli
authors.forename: Rita
authors.initials: R
authors.lastname: Morigi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Granaiola
authors.forename: Lucilla
authors.initials: L
authors.lastname: Varoli
authors.forename: Silvia
authors.initials: S
authors.lastname: Burnelli
authors.forename: Alberto
authors.initials: A
authors.lastname: Leoni
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D003198:Computer Simulation; D004247:DNA / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D011743:Pyrimidines; C553797:bis-guanylhydrazone diimidazo(1,2-a-1,2-c)pyrimidine; D004247:DNA; D008935:Mitoguazone