title: An outbreak of hepatitis A affecting a nursery school and a primary school.
abstract: Between March and June 2008, 12 cases of hepatitis A were notified in Winchester. Cases were from a primary school and a nursery school with no direct linkage. Hepatitis A virus (HAV) RNA sequenced from nine cases confirmed the strain in both schools to be identical. The outbreak could have affected three other schools and a maternity unit and was controlled by immunization and screening of neonates in the maternity unit by dried blood spots. No neonates were infected and no further cases were reported until 5 months later when the index case's mother became infected with same strain of virus associated with the outbreak despite vaccination. Neither the source of the outbreak or the subsequent infection of the index case's mother was identified; however, with the timing of the cases continued transmission in the community by children with asymptomatic infection or a recurrent source cannot be ruled out.
authors.affiliation: Hampshire and Isle of Wight Health Protection Unit, Health Protection Agency, Fareham, UK.
authors.forename: N
authors.initials: N
authors.lastname: McFarland
authors.forename: M
authors.initials: M
authors.lastname: Dryden
authors.forename: M
authors.initials: M
authors.lastname: Ramsay
authors.forename: R S
authors.initials: RS
authors.lastname: Tedder
authors.forename: S L
authors.initials: SL
authors.lastname: Ngui
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage; D030041:Hepatitis A virus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D012367:RNA, Viral / Q000235:genetics; D012574:Schools; D012578:Schools, Nursery; D017422:Sequence Analysis, DNA; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination / Q000379:methods
chemical_list: D022362:Hepatitis A Vaccines; D012367:RNA, Viral