DTNBP1 gene is associated with some symptom factors of schizophrenia in Chinese Han nationality.
OBJECTIVE
To study the association of DTNBP1 gene with some symptom factors of schizophrenia.


METHODS
A total of 285 unrelated schizophrenic individuals were recruited from December 2004 to January 2009 for genetic analysis, and their symptom factors were assessed based on the Positive and Negative Syndrome Scale (PANSS). The quantitative trait test was performed by the UNPHASED program (version 3.0.12) to investigate the association between scored positive and negative symptoms and the single nucleotide polymorphisms (SNPs) in DTNBP1 gene.


RESULTS
The quantitative trait test showed allelic association of rs909706 with the excitement symptom of schizophrenia (P<0.05, adjusted by 10,000 permutations), while the genotype C/G of rs2619539 with a negative symptom, lack of spontaneity and flow of conversation (P<0.05, adjusted by 10,000 permutations).


CONCLUSIONS
DTNBP1 variations are possibly associated with some symptoms of schizophrenia, which could partly explain the relationship between the susceptibility gene DTNBP1 and that disease.
Sun
Yu-hui
YH
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Shen
Yan
Y
Xu
Qi
Q
D000328:Adult; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002681:China; D017931:DNA Primers; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
D002352:Carrier Proteins; D017931:DNA Primers; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins