The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients.
BACKGROUND
Systemic lupus erythematosus (SLE), a multisystemic autoimmune disease, is characterized by the production of a range of autoantibodies against nuclear constituents and other self-antigens. The studies in DNA repair deficiencies in SLE patients have been recently investigated.


OBJECTIVE
Few studies have been conducted on DNA repair gene polymorphisms and their role in autoimmune diseases. Our study purpose was to examine and compare NBS1 genotype distributions in a group of Taiwanese SLE patients and controls in Taiwan.


METHODS
Participants were Taiwanese SLE patients and healthy controls. We studied associations among NBS1 polymorphisms--rs1061302, rs709816, and rs1805794--considering clinical features for the entire group and stratified subgroups. No statistically significant differences between the patients and controls were noted. However, we observed significant decreases in Ht1-GGG, Ht2-AAC, and Ht3-AGC in the SLE patients (Ht1-GGG, OR = 0.26, 95% CI: 0.16-0.41; Ht2-AAC, OR = 0.30, 95% CI: 0.17-0.53; Ht3-AGC, OR = 0.35, 95% CI: 0.19-0.71) and significant increases in Ht4-AAG, Ht5-AGG, and Ht8-GGC among the SLE patients. Combined, these results suggest an association between NBS1 genetic polymorphisms and Taiwanese SLE patients.
Lin
Ying-Ju
YJ
Department of Medical Research, China Medical University Hospital, No.2 Yuh-Der Road, Taichung 404, Taiwan.
Lan
Yu-Ching
YC
Wan
Lei
L
Huang
Chung-Ming
CM
Lin
Cheng-Wen
CW
Hsueh
Kai-Chung
KC
Chen
Da-Yuan
DY
Lin
Ting-Hsu
TH
Tsai
Fuu-Jen
FJ
D018797:Cell Cycle Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D004252:DNA Mutational Analysis; D004260:DNA Repair / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D009687:Nuclear Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013624:Taiwan
D018797:Cell Cycle Proteins; C112156:NBN protein, human; D009687:Nuclear Proteins