Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population.
Our study tested whether an association of the 861C allele of the serotonin 5-HT1B gene (HTR1B) with antisocial alcoholism exists in the German population. The HTR1B G861C polymorphism was genotyped in 588 subjects of German descent, comprising 250 non-alcoholic controls and 338 alcohol-dependent subjects, of whom 56 exhibited a dissocial personality disorder (DSPD). The Tridimensional Personality Questionnaire was assessed in 109 alcohol-dependent males to explore an effect of the 861C allele to risk-taking behaviour. Our results revealed no evidence for an association of the 861C allele with antisocial alcoholism (p > 0.63). There were no significant differences in the personality traits, novelty-seeking, harm avoidance and reward dependence between 46 male alcoholics carrying the 861C allele compared to those 63 alcoholics lacking it (p > 0.52). Our results do not provide evidence that the 861C allele contributes a substantial vulnerability effect to antisocial behavior in German alcohol-dependent subjects.
Sander
T
T
Department of Psychiatry, University Hospital Charité, Campus Virchow Clinic, Humboldt University of Berlin, Berlin, Germany. Sanderth@aol.com
Ostapowicz
A
A
Samochowiec
J
J
Smolka
M
M
Rommelspacher
H
H
Winterer
G
G
Schmidt
L G
LG