Substituted benzenediol Schiff bases as promising new anti-glycation agents.
A feature of diabetes is that the rate of protein glycation and the formation of advanced glycation endproducts (AGEs) increases spontaneously due to the abnormally elevated levels of sugar in the blood. The glycation of proteins is associated with a large number of late diabetic complications (retinopathy, neuropathy, atherosclerosis, end stage renal diseases, rheumatoid arthritis and neurodegenerative diseases). The increase in diabetic complications is a major cause of morbidity and mortality, which has increased significantly in the last two decades. Therefore, there is a considerable recent interest in the identification of lead molecules, which can inhibit the glycation process or slow it down considerably. A new class of anti-glycation agents has been identified, based on the spectrofluorimetric analysis of fluorescent advanced glycation endproducts (AGEs), benzenediol Schiff bases, and their structure-activity relationships have been studied. Some of these compounds have shown a promising anti-glycation potential in vitro.
Choudhary
M Iqbal
MI
H E J Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk
Abbas
Ghulam
G
Ali
Saqib
S
Shuja
Shaukat
S
Khalid
Nasir
N
Khan
Khalid M
KM
Atta-ur-Rahman
Basha
Fatima Z
FZ
D016475:3T3 Cells; D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D001786:Blood Glucose / Q000737:chemistry / Q000378:metabolism*; D048909:Diabetes Complications / Q000097:blood / Q000517:prevention & control; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects*; D006801:Humans; D015416:Maillard Reaction; D051379:Mice; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
D001555:Benzene Derivatives; D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012545:Schiff Bases