title: Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.
abstract: Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, the insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report the complete genome sequence of S. bingchenggensis. The availability of the genome sequence of S. bingchenggensis should enable us to understand the biosynthesis of these structurally intricate antibiotics better and facilitate rational improvement of this strain to increase their titers.
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin, China.
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Yan
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Ji-Jia
authors.initials: JJ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Chen
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Yin
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: Gao
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Liu
authors.forename: Zhao-Xiang
authors.initials: ZX
authors.lastname: Zhu
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics; D004987:Ethers / Q000378:metabolism*; D016680:Genome, Bacterial / Q000235:genetics; D018942:Macrolides / Q000378:metabolism; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013141:Spiro Compounds / Q000378:metabolism*; D013302:Streptomyces / Q000145:classification / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004987:Ethers; D018942:Macrolides; D013141:Spiro Compounds; C452419:nanchangmycin; C027837:moxidectin