Molecular physiology of cellular glucose transport - a potential area for clinical studies in diabetes mellitus.
The normalization of cellular glucose assimilation is the basic aim of metabolic therapy in type 2 diabetes mellitus (T2DM). It requires parallel changes in the process of cellular glucose transport (CGT). This review presents the pathophysiological and clinical outlines of CGT. Sequentially, the advances in the mechanisms and classification of CGT and their physiological and molecular base are described. The role of CGT pathogenetic significance in diabetes mellitus is stressed. Finally, the opinion is expressed that the CGT study is a potentially important approach to clinical interpretation of glucose metabolism disturbances and their pharmacotherapy.
Tatoń
Jan
J
Chair and Department of Internal Diseases and Diabetology, II Medical Faculty, Warsaw Medical University, Bordnowski Hospital, Warszawa. diabetologia@wum.edu.pl
Piatkiewicz
Paweł
P
Czech
Anna
A
D001692:Biological Transport; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism*; D006801:Humans
D051246:Glucose Transport Proteins, Facilitative; D005947:Glucose