New pyrazoline derivatives and their antidepressant activity.
Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities.
Kaplancikli
Zafer Asim
ZA
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Yunus Emre campus Tepebasi, 26470 Eskişehir, Turkey. zakaplan@anadolu.edu.tr
Ozdemir
Ahmet
A
Turan-Zitouni
Gülhan
G
Altintop
Mehlika Dilek
MD
Can
Ozgür Devrim
OD
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry
D000928:Antidepressive Agents; D011720:Pyrazoles; D014230:Triazoles