Retroperitoneal ganglioneuroma in children: CT and MRI features with histologic correlation.
OBJECTIVE
To demonstrate the CT and MRI features with histologic correlation of retroperitoneal ganglioneuromas in children.


METHODS
The diagnostic images (seventeen CT scans and five MR scans) in 17 children with retroperitoneal ganglioneuroma confirmed by operation and histopathology were retrospectively reviewed, and correlated to the histologic findings.


RESULTS
All tumors presented as an oval-shaped, well-defined mass on both CT and MR images. On unenhanced CT images, calcification was detected in six masses (35.3%), and predominantly low attenuation with the CT value ranged from 22 to 38 HU (mean 29.5 HU) in all the tumors. The tumors with CT value less than 30 HU had a relatively larger amount of myxoid stroma on histopathologic sections than those with CT value more than 30 HU. Tumors showed homogeneous low signal intensity on T1-weighted images and inhomogeneous high signal intensity with interlaced or nodular low signal intensity on T2-weighted images. The post-contrast enhancement on both CT and MR images was lacking or slight in early phase, but moderate or marked in late phase. The inhomogeneous high signal intensity on T2WI, as well as the delayed enhancement corresponded to a large amount of myxoid stroma and a relatively small number of cellular components in tumors.


CONCLUSIONS
An oval shape, well-defined margin, low attenuation on CT, inhomogeneous hyperintensity on T2WI, and delayed moderate or marked enhancement are typical features of retroperitoneal ganglioneuroma in children. The imaging features correlated well to the histologic findings.
Cai
Jinhua
J
Department of Radiology, Children's Hospital, Chongqing Medical University, Chongqing 400014, China. cjh710506@tom.com
Zeng
Yan
Y
Zheng
Helin
H
Qin
Yong
Y
T
Kaiyong
K
Zhao
Jiannong
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005729:Ganglioneuroma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis*; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*