title: Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery?
abstract: Log-term prognosis of children suffering from high-risk neuroblastomas is characterized by a shortened event-free survival, especially if metastases remain after chemotherapy. We report the case of a 3-year-old boy afflicted with a stage 4 neuroblastoma and persistent residual lymph node metastases despite the administration of a various number of treatment modalities. The insertion of a MIBG (metaiodobenzylguanidine) single-photon emission computed tomography (SPECT)-CT and radio-guided surgery implementing a hand held gamma probe finally allowed the exact localization and resection of the suspected lymphatic tissue. As a consequence, the child has been under event-free remission for 20 months. Because study-based knowledge is missing due to the small number of affected patients, individual case reports are helpful to improve future treatment strategies.
authors.affiliation: Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany. robin.wachowiak@medizin.uni-leipzig.de
authors.forename: Robin
authors.initials: R
authors.lastname: Wachowiak
authors.forename: Holger
authors.initials: H
authors.lastname: Till
authors.forename: Roman
authors.initials: R
authors.lastname: Metzger
authors.forename: Uta
authors.initials: U
authors.lastname: Bierbach
authors.forename: Thorsten
authors.initials: T
authors.lastname: Simon
authors.forename: Bernhard
authors.initials: B
authors.lastname: Sattler
authors.forename: Thomas
authors.initials: T
authors.lastname: Aigner
authors.forename: Osama
authors.initials: O
authors.lastname: Sabri
authors.forename: Regine
authors.initials: R
authors.lastname: Kluge
mesh_terms: D019797:3-Iodobenzylguanidine; D002675:Child, Preschool; D018572:Disease-Free Survival; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019797:3-Iodobenzylguanidine