[Effect of one-time injection of calcitonin preparations on glucose and calcium level in rats of different age groups].
The effect of domestic preparations of calcitonin (the bull one--thyrocalcitonin and the pig one--calcitrin) on the blood glucose and calcium level in rats was studied. Calcitrin made more effective action on the investigating measures. Calcitrin evoked marked hyperglycemic effect in rats of all age groups (immature, adult, old). More significant rise of blood glucose was detected in immature and old animals. Maximum increase of blood glucose after calcitrin injection in immature rats is 53 +/- 7%, in adult--19 +/- 2%, in old--47 +/- 3% to initial glucose concentration. More marked hypocalcaemia was in immature rats in comparison with adult rats. There are functional (immature), close (adult) and marked (old) negative correlation was established between glucose and calcium level.
Butakova
S S
SS
Nozdrachev
A D
AD
D000375:Aging / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002116:Calcitonin / Q000008:administration & dosage / Q000009:adverse effects*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D051381:Rats
D001786:Blood Glucose; D002116:Calcitonin; D005947:Glucose; D002118:Calcium