title: [Normal tissue tolerance to external beam radiation therapy: liver].
abstract: The liver is a large abdominal organ in the right hypondrium. Because of its anatomical situation, it is near many abdominal PTVs as well as some lower thoracic PVTs. The liver could also be at the same time the target (for irradiation of liver metastases or primary liver tumours) and organ at risk (OAR). Radiation-induced liver disease (RILD) is radiobiologically the normal tissue complication probability (NTCP), i.e., the clinical event limiting the total dose that could be delivered. This review describes radiobiological criteria justifying the NTCP data, and recommendations for conformal 3D radiotherapy and stereotactic liver irradiation.
authors.affiliation: Département de Radiothérapie-Oncologie, Centre Hospitalier Lyon-Sud, Université Claude-Bernard Lyon 1 et EA3738, 69310 Pierre-Bénite, France. berardino.de-bari@chu-lyon.fr
authors.forename: B
authors.initials: B
authors.lastname: De Bari
authors.forename: Y
authors.initials: Y
authors.lastname: Pointreau
authors.forename: E
authors.initials: E
authors.lastname: Rio
authors.forename: X
authors.initials: X
authors.lastname: Mirabel
authors.forename: F
authors.initials: F
authors.lastname: Mornex
mesh_terms: D002784:Cholesterol / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006503:Hepatic Veins / Q000033:anatomy & histology / Q000528:radiation effects; D006801:Humans; D008055:Lipids / Q000502:physiology; D008099:Liver / Q000033:anatomy & histology / Q000502:physiology / Q000528:radiation effects*; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary; D009362:Neoplasm Metastasis / Q000532:radiotherapy; D011169:Portal Vein / Q000033:anatomy & histology / Q000528:radiation effects; D011506:Proteins / Q000378:metabolism; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011836:Radiation Tolerance; D011877:Radionuclide Imaging; D016634:Radiosurgery / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D014682:Vena Cava, Inferior / Q000033:anatomy & histology / Q000528:radiation effects
chemical_list: D008055:Lipids; D011506:Proteins; D002784:Cholesterol; D005947:Glucose