Multishot PROPELLER for high-field preclinical MRI.
With the development of numerous mouse models of cancer, there is a tremendous need for an appropriate imaging technique to study the disease evolution. High-field T(2)-weighted imaging using PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI meets this need. The two-shot PROPELLER technique presented here provides (a) high spatial resolution, (b) high contrast resolution, and (c) rapid and noninvasive imaging, which enables high-throughput, longitudinal studies in free-breathing mice. Unique data collection and reconstruction makes this method robust against motion artifacts. The two-shot modification introduced here retains more high-frequency information and provides higher signal-to-noise ratio than conventional single-shot PROPELLER, making this sequence feasible at high fields, where signal loss is rapid. Results are shown in a liver metastases model to demonstrate the utility of this technique in one of the more challenging regions of the mouse, which is the abdomen.
Pandit
Prachi
P
Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Qi
Yi
Y
Story
Jennifer
J
King
Kevin F
KF
Johnson
G Allan
GA
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D011860:Radiography, Abdominal