title: Predictive value of antimicrobial susceptibility from previous urinary tract infection in the treatment of re-infection.
abstract: Recurrent urinary tract infections are often re-infections; therefore, antimicrobial susceptibility test results from a previous episode may guide the empiric therapy in subsequent episodes. This analysis provides predictive values of the antimicrobial susceptibility of previous Escherichia coli isolates for the treatment of re-infections in routine clinical practice. If resistance to ampicillin, trimethoprim, or ciprofloxacin is detected, re-prescription within 3 months is imprudent. Susceptibility to nitrofurantoin, ciprofloxacin, or trimethoprim in a previous sample supports their prescription for a re-infection within 3 months and up to a year. Resistance to nitrofurantoin is low and, once detected, decays relatively quickly. Nitrofurantoin should be considered as a first-line agent for initial and repeat treatment.
authors.affiliation: Discipline of General Practice, School of Medicine, 1 Distillery Road, NUI Galway, Ireland. akke.vellinga@nuigalway.ie
authors.forename: Akke
authors.initials: A
authors.lastname: Vellinga
authors.forename: Martin
authors.initials: M
authors.lastname: Cormican
authors.forename: Belinda
authors.initials: B
authors.lastname: Hanahoe
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Murphy
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D004927:Escherichia coli Infections / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D055502:Secondary Prevention; D014552:Urinary Tract Infections / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000892:Anti-Infective Agents, Urinary