[CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). CKD-MBD in CKD patients not yet on dialysis; Status Quo].
As late interventions for CKD-MBD from stage 5D have been revealed insufficient, treatment from earlier CKD stages, or predialysis stages, is now being focused. It is very important to investigate the mechanism underlying predialysis CKD-MBD before we proceed to the treatment. In this paper, possible treatment options for CKD-MBD in predialysis patients are briefly presented, according to the knowledge and hypothesized mechanism we have so far. More evidences need to be cumulated for the future guidelines for CKD-MBD in CKD patients not yet on dialysis.
Fujii
Naohiko
N
Medical and Research Center for Nephrology and Transplantation, Hyogo Prefectural Hospital, Nishinomiya.
D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D003956:Dialysis; D019317:Evidence-Based Medicine; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D000090265:Klotho Proteins; D010758:Phosphorus / Q000378:metabolism; D017410:Practice Guidelines as Topic; D014807:Vitamin D / Q000502:physiology
D014807:Vitamin D; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium