The cytokine and chemokine profiles in rhabdomyolysis in a patient with Gaucher disease type II.
This report describes a patient with Gaucher disease type II who developed severe rhabdomyolysis. We treated him successfully and measured various cytokine and chemokine levels sequentially to elucidate the pathophysiology of rhabdomyolysis. The serum levels of interleukin-6, -8, -10, granulocyte colony-stimulating factor, interferon-gamma, and monocyte chemoattractant protein-1 were markedly elevated in the early phase of rhabdomyolysis. These findings indicate that cytokines and chemokines are related to the massive myolysis and regenerating process. A viral infection may have triggered rhabdomyolysis through exaggerated activation of macrophages in our patient. The profiles of cytokines and chemokines should be examined in further cases to increase our understanding of the pathophysiology of rhabdomyolysis.
Wakusawa
K
K
Department of Pediatrics, Tohoku University, Sendai, Japan.
Haginoya
K
K
Ishitobi
M
M
Hino-Fukuyo
N
N
Togashi
N
N
Sato
I
I
Ohura
T
T
Yokoyama
H
H
Kikuchi
M
M
Iinuma
K
K
Tsuchiya
S
S
D016207:Cytokines / Q000097:blood* / Q000145:classification; D005776:Gaucher Disease / Q000097:blood / Q000150:complications* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D012206:Rhabdomyolysis / Q000097:blood / Q000209:etiology / Q000276:immunology
D016207:Cytokines