P2Y nucleotide receptors: promise of therapeutic applications.
Extracellular nucleotides, such as ATP and UTP, have distinct signaling roles through a class of G-protein-coupled receptors, termed P2Y. The receptor ligands are typically charged molecules of low bioavailability and stability in vivo. Recent progress in the development of selective agonists and antagonists for P2Y receptors and study of knockout mice have led to new drug concepts based on these receptors. The rapidly accelerating progress in this field has already resulted in drug candidates for cystic fibrosis, dry eye disease and thrombosis. On the horizon are novel treatments for cardiovascular diseases, inflammatory diseases and neurodegeneration.
Jacobson
Kenneth A
KA
Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. kajacobs@helix.nih.gov <kajacobs@helix.nih.gov>
Boeynaems
Jean-Marie
JM
D000818:Animals; D015195:Drug Design; D015507:Drugs, Investigational / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008024:Ligands; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2 / Q000032:analysis* / Q000502:physiology
D015507:Drugs, Investigational; D008024:Ligands; D018377:Neurotransmitter Agents; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2