Synthesis and cytotoxic activities of group 3 metal complexes having monoanionic tridentate ligands.
Complexes of scandium, yttrium, samarium and neodymium bearing monoanionic tridentate ancillary ligands have been synthesized and characterized. The cytotoxic activities of novel compounds, as well as that of similar compounds previously reported have been evaluated on rat glioma (C6), murine fibrosarcoma (WHEI-164) and human embryonic kidney (HEK-293) cell lines. Scandium complex with quinolinephenoxyamine (NNHO) ligand showed very interesting activity against C6 cell line.
Saturnino
Carmela
C
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte don Melillo, 84084 Fisciano (SA), Italy. saturnino@unisa.it
Napoli
Mariagrazia
M
Paolucci
Gino
G
Bortoluzzi
Marco
M
Popolo
Ada
A
Pinto
Aldo
A
Longo
Pasquale
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008674:Metals, Rare Earth / Q000737:chemistry*; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry; D051381:Rats; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; D011804:Quinolines