title: Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
abstract: The genomes of all retroviruses encode the Gag Pol and Env structural proteins. Human and simian lentiviruses have acquired non-structural proteins among which Nef plays a major role in the evolution of viral infection towards an immunodeficiency syndrome. Indeed, in the absence of a functional nef gene, primate lentiviruses are far less pathogenic than their wild type counterparts. The multiple protein-protein interactions in which Nef is involved all contribute to explain the role played by Nef in HIV- and SIV-associated disease progression. This review summarizes common and distinct features among Nef proteins and how they contribute to increasing HIV and SIV fitness towards their respective hosts.
authors.affiliation: Institut Cochin, CNRS UMR8104, Université Paris Descartes, Paris, France.
authors.forename: Nadine
authors.initials: N
authors.lastname: Laguette
authors.forename: Christelle
authors.initials: C
authors.lastname: Brégnard
authors.forename: Serge
authors.initials: S
authors.lastname: Benichou
authors.forename: Stéphane
authors.initials: S
authors.lastname: Basmaciogullari
mesh_terms: D000818:Animals; D024201:Bystander Effect / Q000276:immunology; D015693:Gene Products, nef / Q000378:metabolism*; D015497:HIV-1 / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D015498:HIV-2 / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D007157:Immunologic Surveillance; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D015693:Gene Products, nef