title: Congenital heart conditions: the 'headache' of assessing a link between PFO and migraine.
abstract: The relationship between patent foramen ovale and migraine is a hotly debated issue. Conflicting data on the association or independence of these conditions have been reported by various study groups around the world. Now, a large-scale case-control study has shown no association between the two entities; however, there were a number of methodological flaws in this study and we are unlikely to see the end of the controversy in the near future.
authors.affiliation: Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Via W. A. Mozart 9, 37040 Legnago, Verona, Italy. jackyheart@libero.it
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rigatelli
mesh_terms: D016022:Case-Control Studies; D019317:Evidence-Based Medicine; D054092:Foramen Ovale, Patent / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors