title: Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging.
abstract: Dynamic hyperpolarized [1-(13)C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner. A 12-second bolus injection of hyperpolarized [1-(13)C]pyruvate is imaged at a 3-second temporal resolution. The observed dynamics are evaluated with regard to cerebral blood volume (CBV), flow, transport, and metabolic exchange with the cerebral lactate pool. A model for brain [1-(13)C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described.
authors.affiliation: Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA. ralph.hurd@ge.com
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Hurd
authors.forename: Yi-Fen
authors.initials: YF
authors.lastname: Yen
authors.forename: James
authors.initials: J
authors.lastname: Tropp
authors.forename: Adolf
authors.initials: A
authors.lastname: Pfefferbaum
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Spielman
authors.forename: Dirk
authors.initials: D
authors.lastname: Mayer
mesh_terms: D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008954:Models, Biological; D019289:Pyruvic Acid / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002247:Carbon Isotopes; D019344:Lactic Acid; D019289:Pyruvic Acid