Tetracyclic chromane derivatives from Rhododendron anthopogonoides.
Four new chromane derivatives, anthopogochromane (1), anthopogochromene A (2), anthopogochromene B (3), and anthopogochromene C (4), and two known compounds, daurichromenic acid (5) and ilicicolinic acid B (6), have been isolated from the Chinese medicinal plant Rhododendron anthopogonoides. The S absolute configuration of the stereogenic carbons in the chromane and chromene rings of 1-4 was determined from their circular dichroism spectra. Compounds 1 and 2 inhibited compound 48/80-induced histamine release from rat peritoneal mast cells.
Iwata
Naoki
N
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba, Japan.
Kitanaka
Susumu
S
D000818:Animals; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D029793:Rhododendron / Q000737:chemistry*; D013237:Stereoisomerism; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D002839:Chromans; D004365:Drugs, Chinese Herbal; C551547:anthopogochromane; C551548:anthopogochromene A; D003189:p-Methoxy-N-methylphenethylamine