Predictive capability of anorectal physiologic tests for unfavorable outcomes following biofeedback therapy in dyssynergic defecation.
The purpose of this study is to evaluate the predictive capability of anorectal physiologic tests for unfavorable outcomes prior to the initiation of biofeedback therapy in patients with dyssynergic defecation. We analyzed a total of 80 consecutive patients who received biofeedback therapy for chronic idiopathic functional constipation with dyssynergic defecation. After classifying the patients into two groups (responders and non-responders), univariate and multivariate analyses were performed to determine the predictors associated with the responsiveness to biofeedback therapy. Of the 80 patients, 63 (78.7%) responded to biofeedback therapy and 17 (21.3%) did not. On univariate analysis, the inability to evacuate an intrarectal balloon (P=0.028), higher rectal volume for first, urgent, and maximal sensation (P=0.023, P=0.008, P=0.007, respectively), and increased anorectal angle during squeeze (P=0.020) were associated with poor outcomes. On multivariate analysis, the inability to evacuate an intrarectal balloon (P=0.018) and increased anorectal angle during squeeze (P=0.029) were both found to be independently associated with a lack of response to biofeedback therapy. Our data show that the two anorectal physiologic test factors are associated with poor response to biofeedback therapy for patients with dyssynergic defecation. These findings may assist physicians in predicting the responsiveness to therapy for this patient population.
Shin
Jae Kook
JK
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Cheon
Jae Hee
JH
Kim
Eun Sook
ES
Yoon
Jin Young
JY
Lee
Jin Ha
JH
Jeon
Soung Min
SM
Bok
Hyun Jung
HJ
Park
Jae Jun
JJ
Moon
Chang Mo
CM
Hong
Sung Pil
SP
Lee
Yong Chan
YC
Kim
Won Ho
WH
D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000503:physiopathology*; D001259:Ataxia / Q000503:physiopathology* / Q000628:therapy; D001676:Biofeedback, Psychology; D003248:Constipation / Q000503:physiopathology / Q000628:therapy; D003672:Defecation / Q000502:physiology*; D019841:Defecography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012007:Rectum / Q000503:physiopathology*; D016896:Treatment Outcome