The use of 5-alpha reductase inhibitors for the prevention of prostate cancer.
The use of 5-alpha-reductase inhibitors has been studied not only in benign prostatic hyperplasia, but as a chemopreventive strategy in prostate cancer. Both finasteride and dutasteride, 5 alpha-reductase inhibitors (5ARI), have been shown to decrease the risk of prostate cancer. The results of the REDUCE trial using the dual alpha-reductase isoenzyme inhibitor dutasteride, has recently been published by Andriole et al. in the New England Journal of Medicine. Certain considerations regarding its use and applicability to men with high risk of developing prostate cancer are herein discussed.
Yu
Eun-mi
EM
Department of Medicine, Division of Hematology and Oncology, George Washington University Medical Center, Washington, DC, USA.
El-Ayass
Walid
W
Aragon-Ching
Jeanny B
JB
D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D042944:Cholestenone 5 alpha-Reductase / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000517:prevention & control*
D058891:5-alpha Reductase Inhibitors; D042944:Cholestenone 5 alpha-Reductase