title: DNA binding and DNA cleavage studies of a water soluble cobalt(II) complex containing dinitrogen Schiff base ligand: the effect of metal on the mode of binding.
abstract: Binding interaction of a water soluble cobalt(II) complex of a Schiff base, SF, (SF = N,N'-bis{5-[(triphenylphosphonium chloride)-methyl] salicylidine}-o-phenylenediamine) with calf thymus DNA (CT-DNA) has been investigated. The intrinsic binding constant (K(b) = 5 x 10(4) M(-1)) was determined. In comparison with previous study the results indicate that the binding affinity of SF is stronger than its Co(II) complex. Multi-spectroscopic experiments reveal that the binding modes of Co(II) complex in comparison with SF are different; SF may be intercalating between DNA base pairs while its Co(II) complex most likely interact with DNA in an electrostatic binding mode.
authors.affiliation: Department of Chemistry, Faculty of Science, Razi University, Kermanshah, Iran. nahidshahabadi@yahoo.c
authors.forename: Nahid
authors.initials: N
authors.lastname: Shahabadi
authors.forename: Soheila
authors.initials: S
authors.lastname: Kashanian
authors.forename: Farivash
authors.initials: F
authors.lastname: Darabi
mesh_terms: D000818:Animals; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D008024:Ligands; D009584:Nitrogen / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism*; D012545:Schiff Bases / Q000737:chemistry*; D012995:Solubility; D013057:Spectrum Analysis; D014783:Viscosity; D014867:Water / Q000737:chemistry*
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D014867:Water; D003035:Cobalt; D004247:DNA; D009584:Nitrogen