New isoflavonolignan with quinone reductase inducing activity from Alhagi pseudalhagi (M.B.).
Bioassay-directed separation of the chloroform extracts from the air-dried aerial part of Alhagi pseudalhagi (M.B.) led to the isolation of a new isoflavonolignan (1), together with five known isoflavones (2-6) (Fig. 1). Their structures were identified on the basis of spectral analysis of NMR, MS, IR, UV and CD spectral evidences. The quinone reductase (QR) inducing activities of the extracts and compound 1 were evaluated and the new isoflavonolignan (1) exhibited moderate quinone reductase (QR) inducing activity for hepa lclc7 cells.
Li
Ning
N
School of Traditional Chinese Materia Medica 49(#), Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China. liningsypharm@163.com
Zhang
Guijie
G
Xiong
Yuanjun
Y
Makhabel
Bolat
B
Li
Xian
X
Jia
Xiaoguang
X
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D035261:Plant Components, Aerial
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D016660:NAD(P)H Dehydrogenase (Quinone)