Mixed Medullary-follicular-derived carcinomas of the thyroid gland.
Tumors of the thyroid are subclassified based on the cell of origin and commonly include follicular-derived tumors and C-cell-derived tumors. The most common follicular-derived tumors are papillary carcinoma and follicular carcinoma, whereas the malignant C-cell-derived tumor is medullary thyroid carcinoma. Rare cases in the literature describe patients who have follicular-derived and C-cell-derived tumors in the same thyroid gland. These can be synchronous but anatomically separate carcinomas, or they can show some mixing of the 2 components. The mixture may be at an interface, as in collision tumors, or can be throughout the entire lesion, as in true mixed medullary-follicular-derived carcinomas. The clinical, histologic, and molecular features of these mixed tumors and the classification guidelines are reviewed.
Sadow
Peter M
PM
Department of Pathology, Massachusetts General Hospital, Boston, 02114, USA.
Hunt
Jennifer L
JL
D018276:Carcinoma, Medullary / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D018265:Carcinoma, Papillary, Follicular / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology*