Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia.
OBJECTIVE
This study aimed to investigate whether the monoamine oxidase (MAO) A and B genes are associated with antipsychotic-induced restless legs syndrome (RLS) in schizophrenia.


METHODS
We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients and divided the subjects into two groups: those with RLS symptoms (n = 96) and those without RLS symptoms (n = 94). Genotyping was performed for the variable number of tandem repeat (VNTR) polymorphism of the MAOA gene and A644G polymorphism of the MAOB gene.


RESULTS
There was no significant difference in the genotype and allele frequencies of all polymorphisms investigated between these two groups. However, the result of global haplotype analysis showed a significant difference in haplotype frequencies between male subjects with and without RLS symptoms (p = 0.013). The interaction between two polymorphisms had a significant effect on the RLS scores of both male (p = 0.047) and female (p = 0.028) patients.


CONCLUSIONS
These data do not suggest that the MAOA gene VNTR and MAOB gene A644G polymorphisms are associated with antipsychotic-induced RLS symptoms in schizophrenia. However, we found that the haplotype frequencies differed between the male schizophrenic patients with and without RLS symptom and the interaction between the two polymorphisms had a significant influence on the RLS scores of patients with schizophrenia.
Kang
Seung-Gul
SG
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
Park
Young-Min
YM
Choi
Jung-Eun
JE
Lim
Se-Won
SW
Lee
Heon-Jeong
HJ
Lee
Seung-Hwan
SH
Kim
Yong-Ku
YK
Kim
Seung-Hyun
SH
Cho
Sung Nam
SN
Kim
Leen
L
D000328:Adult; D000368:Aged; D000483:Alleles; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012148:Restless Legs Syndrome / Q000139:chemically induced* / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy*; D012737:Sex Factors; D055815:Young Adult
D014150:Antipsychotic Agents; D008995:Monoamine Oxidase