title: HLA-G*0105N allele is associated with augmented risk for HIV infection in white female patients.
abstract: We analyzed HLA-G 3777G > C, HLA-G 14 bp deletion/insertion and HLA-G*0105N polymorphisms in HIV-positive white adult participants, infected through horizontal heterosexual transmission, and unexposed uninfected individuals, all from north eastern Italy. We report a new association between the HLA-G*0105N allele and HIV infection in adult white female participants, being HLA-G*0105N null allele correlated with an augmented risk (odds ratio = 4.35, 95% confidence interval = 1.38-18.07, P = 0.005) for HIV infection.
authors.affiliation: Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. segat@burlo.trieste.it
authors.forename: Ludovica
authors.initials: L
authors.lastname: Segat
authors.forename: Eulalia
authors.initials: E
authors.lastname: Catamo
authors.forename: Annalisa
authors.initials: A
authors.lastname: Fabris
authors.forename: Marcello
authors.initials: M
authors.lastname: Morgutti
authors.forename: Pierlanfranco
authors.initials: P
authors.lastname: D'Agaro
authors.forename: Cesare
authors.initials: C
authors.lastname: Campello
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015658:HIV Infections / Q000235:genetics* / Q000635:transmission; D015497:HIV-1 / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D015395:Histocompatibility Antigens Class I