The study of the Golgi apparatus in blood--basic science and clinical applications.
The Golgi apparatus (GA) is a cytoplasmic organelle that is of great interest to all scientists for its key role in the biosynthesis, transporting and sorting of both lipids and proteins located at the intersection of the secretory and endocytic pathways. Recently, more and more evidence shows that changes in the Golgi apparatus play an important role in the clinical progression and pathological development of many diseases. In this review, we will summarize the alteration of the Golgi apparatus in blood cells and anti-Golgi complex antibodies in blood serum under different conditions and further clarify the contribution of the Golgi apparatus dysfunction to the course of these diseases and its pathophysiological basis, which will significantly improve our understanding and impact our ability to develop more effective therapies for these diseases.
Zeng
Liuwang
L
Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Hu
Zhiping
Z
Lu
Wei
W
Tang
Xiangqi
X
Zhang
Jie
J
Li
Ting
T
Yang
Binbin
B
D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000502:physiology; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D006056:Golgi Apparatus / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008533:Megakaryocytes / Q000378:metabolism / Q000473:pathology; D009000:Monocytes / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D010973:Platelet Adhesiveness / Q000502:physiology; D010974:Platelet Aggregation; D013915:Thrombasthenia / Q000097:blood / Q000235:genetics; D018631:ras Proteins / Q000378:metabolism
D018631:ras Proteins