Role of histone acetylation in cell physiology and diseases: An update.
Although the role of histone acetylation in gene regulation has been the subject of many reviews, their impact on cell physiology and pathological states of proliferation, differentiation and genome stability in eukaryotic cells remain to be elucidated. Therefore, this review will discuss the molecular, physiological and biochemical aspects of histone acetylation and focus on the interplay of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in different disease states. Current treatment strategies are mostly limited to enzyme inhibitors, though potential lies in targeting other imperative chromatin remodeling factors involved in gene regulation.
Khan
Shahper N
SN
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
Khan
Asad U
AU
D000107:Acetylation; D000818:Animals; D002468:Cell Physiological Phenomena / Q000502:physiology*; D004194:Disease / Q000209:etiology; D051548:Histone Acetyltransferases / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism / Q000502:physiology*; D006801:Humans
D006657:Histones; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases