title: [Clinical and histopathological results after the neo-adjuvant treatment of advanced rectal tumors].
abstract: The role of the surgical intervention is decisive in treating colorectal tumors. The neo-adjuvant radio-chemotherapy has improved the efficacy of the treatment of advanced rectum tumors. In order to decrease the size and stage of advanced rectal carcinoma and to increase the rate of resecability, we introduced neoadjuvant radio-chemotherapy. We carried out neo-adjuvant and surgical treatment in case of 67 patients with rectal adenocarcinoma (T 2-4 N 1-2 M 0 ) between June 1, 2005 and July 31, 2008. The average age of the patients was 61.2 years, the division according to sex was 44 males/23 females. Regarding the local stage of the rectal process or the proximity to the sphincter, we applied radio-chemotherapy (radiotherapy 25 times altogether 45 Gy and on the first and last week for 5-5 days they received 350 mg/m 2 /day 5-FU and 20 mg/m 2 /day leucovorin chemotherapy, recently complemented with 3 x 1.8 Gy advanced boost radiation aiming at the macroscopic tumor site with security zone). Patients underwent surgery 8 weeks on average after restaging examinations. Thirty-eight patients underwent anterior rectal resection with double stapler procedure; there were 18 abdominoperineal rectal extirpations, 7 Hartmann operations and 4 per annum excisions. Compared to the preoperative staging, the histological evaluation of the resected specimens showed total remission (pT 0 N 0 ) in 11% and partial remission in 43%. The morbidity necessitating reoperation was 5.9%, without mortality and suture insufficiency. The long-term neo-adjuvant oncological treatment led to down-staging of rectal tumors in most cases and increased the resecability and rate of resection operations.
authors.affiliation: Szegedi Tudományegyetem AOK Sebészeti Klinika 6720 Szeged Pécsi u. 6. va@surg.szote.u-szeged.hu
authors.forename: László
authors.initials: L
authors.lastname: Varga
authors.forename: Gellért
authors.initials: G
authors.lastname: Baradnay
authors.forename: József
authors.initials: J
authors.lastname: Hohn
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Simonka
authors.forename: Katalin
authors.initials: K
authors.lastname: Hideghéthy
authors.forename: Anikó
authors.initials: A
authors.lastname: Maráz
authors.forename: Alíz
authors.initials: A
authors.lastname: Nikolényi
authors.forename: Blanka
authors.initials: B
authors.lastname: Veréb
authors.forename: László
authors.initials: L
authors.lastname: Tiszlavicz
authors.forename: István
authors.initials: I
authors.lastname: Németh
authors.forename: Eszter
authors.initials: E
authors.lastname: Mán
authors.forename: György
authors.initials: G
authors.lastname: Lázár
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D017024:Chemotherapy, Adjuvant; D013505:Digestive System Surgical Procedures / Q000379:methods*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor