Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases.
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone, secreted from the enteroendocrine K cells, which has insulin-releasing and extra-pancreatic actions. GIP and its receptor present a widespread distribution in the mammalian brain where they have been implicated with synaptic plasticity, neurogenesis, neuroprotection and behavioral alterations. This review attempts to provide a comprehensive picture of the role of GIP in the central nervous system and to highlight recent findings from our group showing its potential involvement in neurological illnesses including epilepsies, Parkinson's disease and Alzheimer's disease.
Figueiredo
Cláudia P
CP
Departamento de Ciências Fisiológicas, Hospital Universitário dDepartamento de Clínica Médica, Hospital Universitário, Universidade Federal de Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Pamplona
Fabrício A
FA
Mazzuco
Tânia L
TL
Aguiar
Aderbal S
AS
Walz
Roger
R
Prediger
Rui Daniel Schröder
RD
D000818:Animals; D002490:Central Nervous System / Q000502:physiology / Q000503:physiopathology; D016503:Drug Delivery Systems; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism*
D011964:Receptors, Gastrointestinal Hormone; D005749:Gastric Inhibitory Polypeptide; C041086:gastric inhibitory polypeptide receptor