Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder.
OBJECTIVE
Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Neurotrophin-3 (NTF3), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, has been identified as a factor in the development of ADHD. We investigated the relationships between ADHD and NTF3 gene polymorphism.


METHODS
We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test (TDT) on 151 trios, and compared the intelligence quotient (IQ) and a continuous performance test (CPT) according to the genotype of two single-nucleotide polymorphisms (SNPs) (rs6332 and rs6489630) in the NTF3 gene.


RESULTS
In the case-control and family-based analyses, NTF3 was not significantly associated with ADHD. However, in the ADHD probands, the subjects with AA genotype in the rs6332 SNP had significantly higher mean T-scores for commission errors on the CPT than did those with the AG genotypes (p=0.045). The mean IQ of the ADHD probands who had the CC genotype of the rs6489630 SNP were higher compared with those who had the CT or TT genotype (p=0.035). The mean T-score for response time on the CPT was higher in the subjects with TT genotype in the rs6489630 SNP compared to those with the CC or CT genotype, even after adjusting for the effect of IQ (p=0.021).


CONCLUSIONS
These results provide preliminary evidence of an association between NTF3 and the intelligence and selective attention deficit in the Korean population.
Cho
Soo-Churl
SC
Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Republic of Korea.
Kim
Hyo-Won
HW
Kim
Boong-Nyun
BN
Kim
Jae-Won
JW
Shin
Min-Sup
MS
Cho
Dae-Yeon
DY
Chung
Seockhoon
S
Jung
Sun-Woo
SW
Yoo
Hee Jeong
HJ
Chung
In-Won
IW
Chung
Un-Sun
US
Son
Jung-Woo
JW
D000483:Alleles; D044466:Asian People / Q000235:genetics; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D009483:Neuropsychological Tests; D020933:Neurotrophin 3 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D020933:Neurotrophin 3