title: Field efficacy of an inactivated bivalent influenza vaccine in a multi-site swine production system during an outbreak of systemic porcine circovirus associated disease.
abstract: Swine influenza (SI) is a disease of significance for the swine industry, and vaccination is often recommended as a way to reduce its impact on production. The efficacy of SI vaccines is well established under experimental conditions, but information about field efficacy is scarce. The objective of this study was to evaluate the efficacy of a commercial inactivated bivalent (H1N1/H3N2) vaccine under conditions of natural exposure to a field SI variant. To accomplish our goal we used a randomized, blinded, field trial in 2 cohorts of finisher pigs in a multi-site swine production system located in southern Ontario. During the trial, this herd experienced an outbreak of porcine circovirus associated disease (PCVAD). The efficacy of the SI vaccine was assessed through its effect on average daily weight gain, and serological responses to SI over time. The effect of vaccination on pig growth was different in the 2 cohorts. Weight gain was higher in vaccinated pigs than in control pigs in Cohort 1, but was numerically higher for control pigs than for vaccinated pigs in Cohort 2. Vaccination against swine influenza, in a herd experiencing an outbreak of PCVAD, was of questionable value.
authors.affiliation: Department of Population Medicine, University of Guelph, Ontario, Canada. zpoljak@uoguelph.ca <zpoljak@uoguelph.ca>
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Poljak
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Dewey
authors.forename: S Wayne
authors.initials: SW
authors.lastname: Martin
authors.forename: Jette
authors.initials: J
authors.lastname: Christensen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Friendship
mesh_terms: D000818:Animals; D018173:Circoviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017925:Circovirus; D007252:Influenza Vaccines / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control* / Q000821:virology; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated