title: Lower limb osteoarthritis: biomechanical alterations and implications for therapy.
abstract: OBJECTIVE
  To review the role of biomechanics in the pathogenesis of lower-extremity osteoarthritis and recent advances in biomechanically active intervention strategies for osteoarthritis.
  
  
  RESULTS
  The conventional approach to treating knee osteoarthritis with analgesics and physical therapy has not been shown to alter the natural history of the disease, suggesting that novel strategies are necessary. Progression of lower-extremity osteoarthritis is mediated by aberrant biomechanics, which can be assessed using gait analyses and validated markers of dynamic knee loading such as the peak adduction moment (AddM) and adduction angular impulse (AddImp). Recognition of the mechanical component of osteoarthritis progression has led to intervention strategies that seek to reduce functional loads at the knee, and thereby, potentially, to palliate pain and retard disease progression.
  
  
  CONCLUSIONS
  Biomechanically active interventions have been demonstrated to reduce dynamic loading of the knees in patients with osteoarthritis, and are potentially promising strategies to treat symptoms as well as to alter disease progression in osteoarthritis.
authors.affiliation: Section of Rheumatology, Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA. jblock@rush.edu
authors.forename: Joel A
authors.initials: JA
authors.lastname: Block
authors.forename: Najia
authors.initials: N
authors.lastname: Shakoor
mesh_terms: D001696:Biomechanical Phenomena; D001915:Braces; D005081:Exercise Therapy; D005684:Gait / Q000502:physiology; D006801:Humans; D009989:Orthotic Devices; D020370:Osteoarthritis, Knee / Q000503:physiopathology* / Q000628:therapy*; D016474:Weight-Bearing