Computational approaches to neuronal network analysis.
Computational modelling is an approach to neuronal network analysis that can complement experimental approaches. Construction of useful neuron and network models is often complicated by a variety of factors and unknowns, most notably the considerable variability of cellular and synaptic properties and electrical activity characteristics found even in relatively 'simple' networks of identifiable neurons. This chapter discusses the consequences of biological variability for network modelling and analysis, describes a way to embrace variability through ensemble modelling and summarizes recent findings obtained experimentally and through ensemble modelling.
Prinz
Astrid A
AA
Department of Biology, Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA. astrid.prinz@emory.edu
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*