[Comparison of pharmacokinetics about ermiao capsules and ermiao pellet].
OBJECTIVE
To compare the pharmacokinetics about Ermiao capsules and ermiao pellet, and observe the changes in plasma concentration with different formulations in animals from the perspective of pharmacokinetics.


METHODS
After the rabbits were administered with Ermiao capsules and ermiao pellet through ig. HPLC was used to determine berberine in blood plasma at different times, DAS 2.0 procedure was used to process concentration-time data.


RESULTS
In the rabbit plasma samples,the linear range of berberine was 0.00427-0.427 microg/mL, it has a high extract recovery rate,and day-day precision RSD was less than 10%. The whole blood concentration-time course of berberine in Ermiao capsules was fitted to be a two-compartment model, and berberine in Ermiao pellet was fitted to be a one-compartment model.


CONCLUSIONS
This essay establishes a method for determine berberine in rabbit plasma, provided the pharma cokinetic parameters for rational administration of ermiao capsules, and also provided the pharmacokinetic study method of compounds.
Zhou
Ling
L
Liaoning University of TCM, Dalian 116600, China. zhouling0824@126.com
Sun
Zhao-shu
ZS
Dou
De-qiang
DQ
Cao
Ai-min
AM
Kang
Ting-guo
TG
D000818:Animals; D019540:Area Under Curve; D031174:Atractylodes / Q000737:chemistry*; D001599:Berberine / Q000097:blood / Q000493:pharmacokinetics*; D001600:Berberine Alkaloids / Q000097:blood / Q000493:pharmacokinetics; D002214:Capsules; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D024301:Plant Bark / Q000737:chemistry; D011817:Rabbits; D015203:Reproducibility of Results; D027343:Rhizome / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
D001600:Berberine Alkaloids; D002214:Capsules; D004365:Drugs, Chinese Herbal; D001599:Berberine; C014215:tetrahydropalmatine