Pro-inflammatory cytokines in Omani type 2 diabetic patients presenting anxiety and depression.
BACKGROUND
The relationship of inflammatory cytokines with anxiety and depression has been reported, but their role in diabetic patients has not been fully elucidated.


OBJECTIVE
We examined whether an association between prevalence of anxiety and depression in Omani type-2 diabetic patients (n=30) and the levels of inflammatory markers such as IL-1ß, TNF-α, IFN-γ and C-reactive protein (CRP) exists.


METHODS
Symptoms of anxiety and depression were screened using the Hospital Anxiety and Depression Scale (HADS) through self-rated questionnaires. IL-1ß, TNF-α, IFN-γ, CRP, anti-TPO and anti-GAD65 antibodies were measured in patients' sera using commercially available ELISA assays.


RESULTS
In Omani type-2 diabetic patients, high prevalence of anxiety and depression along with high levels of inflammatory markers were detected. However, no correlation was observed between inflammatory markers and anxiety or depression.


CONCLUSIONS
These results indicate that Omani type-2 diabetic patients are at great risk for developing anxiety and depression. Therefore, these complications need more care and attention. There was no association between scores of anxiety and depression with the levels of inflammatory cytokines. This may need to be elucidated in a larger cohort of patients.
Al-Maskari
Masoud
M
Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman. mmaskari@squ.edu.om
Al-Shukaili
Ahmed
A
Al-Mammari
Ali
A
D000328:Adult; D001007:Anxiety / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000276:immunology* / Q000523:psychology; D001323:Autoantibodies / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D003863:Depression / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000276:immunology* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000523:psychology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009850:Oman; D015995:Prevalence
D001323:Autoantibodies; D016207:Cytokines; D018836:Inflammation Mediators; D002097:C-Reactive Protein; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2