title: Bri2-23 is a potential cerebrospinal fluid biomarker in multiple sclerosis.
abstract: To identify potential multiple sclerosis (MS)-specific biomarkers, we used a proteomic approach to screen cerebrospinal fluid (CSF) from 40 MS patients and 13 controls. We identified seven proteins (Beta-2-microglobulin, Bri2-23, Fetuin-A, Kallikrein-6, Plasminogen, Ribonuclease-1, and Transferrin) that had significantly altered levels in MS compared to controls. Clinical subgroup analysis revealed that decreased CSF levels of Bri2-23, a peptide cleaved from Bri2, were significantly associated with patients having cerebellar dysfunction and cognition impairment. Furthermore, expression levels of Bri2 were specifically decreased in the cerebellum compared to other areas of same brain in MS but not in controls, suggesting that decreased cerebellar Bri2 expression may play a role in cerebellar dysfunction. The association with cognition impairment is also of interest because Bri2 is linked to the amyloid processing pathway in the brain. CSF levels of Bri2-23 may serve as a biomarker of these functions in MS and merits further investigation.
authors.affiliation: Multiple Sclerosis Research Center of New York, New York, NY 10019, USA.
authors.forename: Violaine K
authors.initials: VK
authors.lastname: Harris
authors.forename: Andrew
authors.initials: A
authors.lastname: Diamanduros
authors.forename: Pamela
authors.initials: P
authors.lastname: Good
authors.forename: Elina
authors.initials: E
authors.lastname: Zakin
authors.forename: Varun
authors.initials: V
authors.lastname: Chalivendra
authors.forename: Saud A
authors.initials: SA
authors.lastname: Sadiq
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002526:Cerebellar Diseases / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000378:metabolism*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000378:metabolism*; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; C120083:ITM2B protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins