Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.
OBJECTIVE
To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS).


METHODS
Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1Glu69 in additive, dominant, and recessive inheritance models.


RESULTS
IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized.


CONCLUSIONS
These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS.
McCanlies
Erin C
EC
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. eim4@cdc.gov
Yucesoy
Berran
B
Mnatsakanova
Anna
A
Slaven
James E
JE
Andrew
Michael
M
Frye
Bonnie L
BL
Schuler
Christine R
CR
Kreiss
Kathleen
K
Weston
Ainsley
A
D001607:Berylliosis / Q000235:genetics* / Q000276:immunology; D001608:Beryllium / Q000276:immunology*; D002908:Chronic Disease; D015331:Cohort Studies; D056726:Genetic Association Studies; D006682:HLA-DP Antigens / Q000235:genetics / Q000276:immunology; D059868:HLA-DP beta-Chains; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics* / Q000276:immunology; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D016906:Interleukin-9 / Q000235:genetics / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D053651:Receptors, Interleukin-9 / Q000235:genetics / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000235:genetics* / Q000276:immunology
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; C508607:IL9 protein, human; D007375:Interleukin-1; D007376:Interleukin-2; D016906:Interleukin-9; D053651:Receptors, Interleukin-9; D001608:Beryllium