title: Efficacy of bosentan in digital ischemic ulcers.
abstract: Thromboangiitis obliterans (also known as Buerger's disease) is an inflammatory vascular disorder that affects small and medium-sized arteries and veins in the extremities. There is no specific treatment and the only effective intervention is absolute cessation of tobacco use. Endothelial dysfunction appears to be of relevance to this condition and a report has even found that high serum levels of endothelin correlate with the presence of necrosis. We report two cases of digital necrosis showing a very satisfactory response to treatment with bosentan, a dual endothelin receptor antagonist.
authors.affiliation: Internal Medicine Department, Hospital Universitario La Fe, Valencia, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Todoli Parra
authors.forename: Manuel Miralles
authors.initials: MM
authors.lastname: Hernández
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Arrébola López
mesh_terms: D000368:Aged; D000077300:Bosentan; D065128:Endothelin Receptor Antagonists; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D018810:Magnetic Resonance Angiography; D008297:Male; D020678:Microscopic Angioscopy; D008875:Middle Aged; D010991:Plethysmography; D012883:Skin Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016540:Smoking Cessation; D013449:Sulfonamides / Q000627:therapeutic use*; D013919:Thromboangiitis Obliterans / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D065128:Endothelin Receptor Antagonists; D013449:Sulfonamides; D014665:Vasodilator Agents; D000077300:Bosentan