Renewal of sucrose-seeking behavior in rats: Role of D(2) dopamine receptors.
The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D(2)) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D(2) dopamine receptor antagonist eticlopride (5, 10, 20, or 40microg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40microg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D(2) dopamine receptors in mediating renewal of sucrose-seeking behavior.
Rauhut
Anthony S
AS
Department of Psychology, James Hall, Dickinson College, Carlisle, PA 17013, USA. rauhuta@dickinson.edu
Fenton
Laura
L
Bardo
Michael T
MT
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D012055:Reinforcement Schedule; D012457:Salicylamides / Q000494:pharmacology; D013395:Sucrose
D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D013395:Sucrose; C045989:eticlopride