Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
The genomes of all retroviruses encode the Gag Pol and Env structural proteins. Human and simian lentiviruses have acquired non-structural proteins among which Nef plays a major role in the evolution of viral infection towards an immunodeficiency syndrome. Indeed, in the absence of a functional nef gene, primate lentiviruses are far less pathogenic than their wild type counterparts. The multiple protein-protein interactions in which Nef is involved all contribute to explain the role played by Nef in HIV- and SIV-associated disease progression. This review summarizes common and distinct features among Nef proteins and how they contribute to increasing HIV and SIV fitness towards their respective hosts.
Laguette
Nadine
N
Institut Cochin, CNRS UMR8104, Université Paris Descartes, Paris, France.
Brégnard
Christelle
C
Benichou
Serge
S
Basmaciogullari
Stéphane
S
D000818:Animals; D024201:Bystander Effect / Q000276:immunology; D015693:Gene Products, nef / Q000378:metabolism*; D015497:HIV-1 / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D015498:HIV-2 / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D007157:Immunologic Surveillance; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity
D015693:Gene Products, nef