title: The genome sequence of the crenarchaeon Acidilobus saccharovorans supports a new order, Acidilobales, and suggests an important ecological role in terrestrial acidic hot springs.
abstract: Acidilobus saccharovorans is an anaerobic, organotrophic, thermoacidophilic crenarchaeon isolated from a terrestrial hot spring. We report the complete genome sequence of A. saccharovorans, which has permitted the prediction of genes for Embden-Meyerhof and Entner-Doudoroff pathways and genes associated with the oxidative tricarboxylic acid cycle. The electron transfer chain is branched with two sites of proton translocation and is linked to the reduction of elemental sulfur and thiosulfate. The genomic data suggest an important role of the order Acidilobales in thermoacidophilic ecosystems whereby its members can perform a complete oxidation of organic substrates, closing the anaerobic carbon cycle.
authors.affiliation: Centre Bioengineering, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Mardanov
authors.forename: Vitali A
authors.initials: VA
authors.lastname: Svetlitchnyi
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Beletsky
authors.forename: Maria I
authors.initials: MI
authors.lastname: Prokofeva
authors.forename: Elizaveta A
authors.initials: EA
authors.lastname: Bonch-Osmolovskaya
authors.forename: Nikolai V
authors.initials: NV
authors.lastname: Ravin
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Skryabin
mesh_terms: D019615:Crenarchaeota / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D019641:DNA, Archaeal / Q000737:chemistry / Q000235:genetics; D004579:Electron Transport; D020745:Genome, Archaeal; D045482:Hot Springs / Q000382:microbiology*; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D017422:Sequence Analysis, DNA
chemical_list: D019641:DNA, Archaeal