Inflammatory bowel diseases, celiac disease, and bone.
The article summarizes the current knowledge on the pathogenesis, clinical aspects and treatment of bone problems in the major inflammatory bowel diseases (Crohn's disease and ulcerative colitis) and celiac disease. It presents the physiological relationship between intestine and bone as well as the alterations determined by disease-disrupted intestinal integrity. Two hypotheses about the pathogenetic mechanisms of bone metabolism derangements and bone loss are discussed: the classical one, that indicates calcium malabsorption as the main culprit, and the new one, that emphasizes the role of inflammation. The article summarizes the available epidemiological data about osteopenia/osteoporosis and fragility fractures in these chronic intestinal diseases and presents the state-of-the-art treatment options.
Bianchi
Maria Luisa
ML
Istituto Auxologico Italiano IRCCS, Milano, Italy. ml.bianchi@auxologico.it
D000818:Animals; D001862:Bone Resorption / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy; D001842:Bone and Bones / Q000378:metabolism; D002446:Celiac Disease / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy