title: Retinal nerve fibre layer evaluation in ocular hypertensive eyes using optical coherence tomography and scanning laser polarimetry in the diagnosis of early glaucomatous defects.
abstract: OBJECTIVE
  To evaluate and compare the accuracy of scanning laser polarimetry with variable corneal compensation (GDx-VCC) and optical coherence tomography (OCT) for detecting glaucomatous damage observed in retinal nerve fibre layer (RNFL) monochromatic photographs from ocular hypertensive (OHT) individuals with normal visual fields.
  
  
  METHODS
  A total of 181 eyes from 181 patients with intraocular pressure >22 mm Hg were enrolled in a cross-sectional, hospital clinic-based study. All patients underwent full ophthalmological examination, standard automated perimetry, red-free digital RNFL photographs, and RNFL imaging with Stratus OCT and GDx-VCC. Subjects were divided into two groups according to observations from RNFL photographs: 128 OHT subjects without and 53 OHT subjects with RNFL defects. Receiver operating characteristic (ROC) curves plotted for the RNFL parameters were compared between OCT and GDx-VCC.
  
  
  RESULTS
  The OCT parameter with the highest diagnostic accuracy for detecting early RNFL defects was average thickness, and for the GDx-VCC was temporal-superior-nasal-inferior-temporal average, with areas under the ROC curve of 0.785 and 0.758, respectively (all AUCs p<0.001).
  
  
  CONCLUSIONS
  OCT and GDx have similar diagnostic accuracy for identifying early defects detected by RNFL monochromatic photography in OHT patients.
authors.affiliation: Department of Ophthalmology, Miguel Servet University Hospital, Instituto Aragone's de Ciencias de Salud, Zaragoza, Spain.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Pablo
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreras
authors.forename: Patricio G
authors.initials: PG
authors.lastname: Schlottmann
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis*; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D057109:Scanning Laser Polarimetry; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult