Replication of KIF21B as a susceptibility locus for multiple sclerosis.
BACKGROUND
Knowledge of genetic susceptibility to autoimmune disorders is growing exponentially. One of the messages emerging from these data is the growing overlap in genetic susceptibility to different autoimmune disorders. KIF21B is a member of the kinesin superfamily and was recently established as a susceptibility locus for inflammatory bowel disease and for multiple sclerosis.


RESULTS
We here replicate the association with multiple sclerosis in a Belgian study population of 791 patients and 1098 controls.


CONCLUSIONS
As SNPs in KIF21B increase risk for both inflammatory bowel disease and multiple sclerosis, this suggests a common pathway in the pathogenesis of these diseases.
Goris
A
A
Laboratory for Neuroimmunology, Section of Experimental Neurology, O&N2, Herestraat 49, Box 1022, 3000 Leuven, Belgium. an.goris@med.kuleuven.be
Boonen
S
S
D'hooghe
M-B
MB
Dubois
B
B
D000483:Alleles; D001530:Belgium; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C550348:KIF21B protein, human; D016547:Kinesins