title: Depressive behaviour in children diagnosed with a mitochondrial disorder.
abstract: A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism.
authors.affiliation: Nijmegen Centre for Mitochondrial Disorders and Department of Paediatrics, Radboud University Nijmegen Medical Centre, IGMD, Nijmegen, The Netherlands. E.Morava@cukz.umcn.nl
authors.forename: E
authors.initials: E
authors.lastname: Morava
authors.forename: T
authors.initials: T
authors.lastname: Gardeitchik
authors.forename: T
authors.initials: T
authors.lastname: Kozicz
authors.forename: L
authors.initials: L
authors.lastname: de Boer
authors.forename: S
authors.initials: S
authors.lastname: Koene
authors.forename: M C
authors.initials: MC
authors.lastname: de Vries
authors.forename: R
authors.initials: R
authors.lastname: McFarland
authors.forename: T
authors.initials: T
authors.lastname: Roobol
authors.forename: R J T
authors.initials: RJ
authors.lastname: Rodenburg
authors.forename: C M
authors.initials: CM
authors.lastname: Verhaak
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007406:Interview, Psychological; D008297:Male; D028361:Mitochondrial Diseases / Q000150:complications*; D010085:Oxidative Phosphorylation