title: Oxygen sensing: a common crossroad in cancer and neurodegeneration.
abstract: Prolyl hydroxylase domain (PHD) proteins are cellular oxygen sensors that orchestrate an adaptive response to hypoxia and oxidative stress, executed by hypoxia-inducible factors (HIFs). By increasing oxygen supply, reducing oxygen consumption, and reprogramming metabolism, the PHD/HIF pathway confers tolerance towards hypoxic and oxidative stress. This review discusses the involvement of the PHD/HIF response in two, at first sight, entirely distinct pathologies with opposite outcome, i.e. cancer leading to cellular growth and neurodegeneration resulting in cell death. However, these disorders share common mechanisms of sensing oxygen and oxidative stress. We will focus on how PHD/HIF signaling is pathogenetically implicated in metabolic and vessel alterations in these diseases and how manipulation of this pathway might offer novel treatment opportunities.
authors.affiliation: Vesalius Research Center (VRC), VIB, K.U. Leuven, Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium.
authors.forename: Annelies
authors.initials: A
authors.lastname: Quaegebeur
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D000818:Animals; D015687:Cell Hypoxia; D006801:Humans; D019194:Ischemic Preconditioning; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011393:Procollagen-Proline Dioxygenase / Q000502:physiology; D015398:Signal Transduction
chemical_list: D011393:Procollagen-Proline Dioxygenase; D010100:Oxygen