Time course of plasma microparticle concentrations after acute spontaneous basal ganglia hemorrhage.
OBJECTIVE
To examine the changes in plasma microparticle (MP) levels in patients after intracerebral hemorrhage (ICH) and assess their association with outcome along with biological markers of the acute phase response.


METHODS
Thirty healthy controls and 86 patients with acute ICH were recruited. Plasma samples were obtained on admission and at days 1, 2, 3, 5, and 7 after ICH. MPs with procoagulant potential were measured with a prothrombinase assay.


RESULTS
Plasma MP levels in patients were substantially higher than those in healthy controls during the 7-day period. Plasma MP levels were strongly associated with outcome and with biological markers of the acute phase response. Multivariate analysis showed baseline plasma MP level was a good predictor of 1-week mortality (odds ratio, 1.930; 95% confidence interval, 1.229-3.031; P=0.004). A receiver operating characteristic curve identified the plasma MP cutoff level (8.4 nmol/l phosphatidylserine equivalent) that predicted 1-week mortality with high sensitivity (90.6%) and specificity (68.5.0%) (P<0.001).


CONCLUSIONS
Increased membrane microparticle levels occur after ICH and may contribute to the subsequent brain injury, in association with a poor clinical outcome.
Dong
X-Q
XQ
Department of Neurosurgery, The First Hangzhou Municipal People's Hospital, Nanjing Medical University, 261 Huansha Road, Hangzhou, China. ysbdxq@163.com
Huang
M
M
Hu
Y-Y
YY
Yu
W-H
WH
Zhang
Z-Y
ZY
D000368:Aged; D019540:Area Under Curve; D020145:Basal Ganglia Hemorrhage / Q000097:blood* / Q000401:mortality*; D015415:Biomarkers / Q000097:blood; D055252:Cell-Derived Microparticles; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D020127:Recovery of Function; D016019:Survival Analysis; D013995:Time
D015415:Biomarkers