title: Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows.
abstract: Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vd(area), AUC, t(1/2beta), Cl(B), MRT and P/C ratio were 0.50 +/- 0.19 L.kg(-1), 62.2 +/- 23.3 microg.ml(-1).h, 1.02 +/- 0.07 h, 0.30 +/- 0.09 L.kg(-1).h(-1), 1.55 +/- 0.25 h and 0.52 +/- 0.27, respectively, in healthy and 1.55 +/- 0.52 L.kg(-1), 37.0 +/- 17.1 microg.ml(-1).h, 1.56 +/- 0.25 h, 0.56 +/- 0.14 L.kg(-1).h(-1), 2.14 +/- 0.34 h and 1.44 +/- 0.60, respectively, in endometritic cows. The drug was detected in milk for 36 h after administration. For MIC(90) of 0.5 microg.ml(-1) the most appropriate dosage for ceftriaxone, would be 9.0 mg.kg(-1) repeated at 6 h intervals for the treatment of endometritis in cows.
authors.affiliation: Division of Animal Reproduction, Gynaecology & Obstetrics, Faculty of Veterinary Sciences & Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences & Technology of Jammu R.S.Pura Campus, Jammu, (J&K)-181102, India. drsudarshandogra@yahoo.com
authors.forename: Sudershan
authors.initials: S
authors.lastname: Kumar
authors.forename: Anil K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: V K
authors.initials: VK
authors.lastname: Dumka
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
authors.forename: Rajinder K
authors.initials: RK
authors.lastname: Raina
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D019540:Area Under Curve; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002443:Ceftriaxone / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004715:Endometriosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008826:Microbial Sensitivity Tests; D008892:Milk / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone