Efficacy of intrauterine lignocaine plus vaginal misoprostol for pain relief in premenopausal women undergoing endometrial aspiration and ambulatory hysteroscopy.
OBJECTIVE
To compare the effectiveness of a combination of intrauterine lignocaine and vaginal misoprostol in reducing pain at hysteroscopy and endometrial aspiration (EA).


METHODS
Prospective randomized trial (Canadian Task Force Classification I).


METHODS
Tertiary care referral hospital.


METHODS
Forty-nine premenopausal women undergoing hysteroscopy plus EA.


METHODS
Patients were randomized into misoprostol plus intrauterine lignocaine group (Group I) and only misoprostol group (Group II).


METHODS
Pain scores at hysteroscope insertion (T (time) 1), during and after hysteroscopy (T2, T3), during EA (T4), 15 minutes after the procedure (T5) and at discharge (T6). Satisfaction and procedure acceptability was assessed by a questionnaire.


RESULTS
The mean age of patients in Group I and Group II was 35.4 +/- 8.6 years and 38.9 +/- 13.2 years, respectively. The mean pain scores in Group I were 23.6% lower at T2 and 27% lower at T4 when compared with Group II; the difference of latter being significant.


CONCLUSIONS
A combination of intrauterine lignocaine plus vaginal misoprostol reduced the pain score in premenopausal women undergoing hysteroscopy and EA.
Gupta
Nupur
N
Department of Obstetrics & Gynaecology, Sukhda Hospital, New Delhi, India. nupurkothari2000@yahoo.com
Gupta
Bindiya
B
Dadhwal
Vatsla
V
Mittal
Suneeta
S
D000282:Administration, Intravaginal; D000328:Adult; D000553:Ambulatory Care; D000779:Anesthetics, Local / Q000627:therapeutic use*; D044963:Biopsy, Fine-Needle; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008012:Lidocaine / Q000627:therapeutic use; D016595:Misoprostol / Q000627:therapeutic use; D010120:Oxytocics / Q000627:therapeutic use*; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D017060:Patient Satisfaction; D017697:Premenopause; D011446:Prospective Studies
D000779:Anesthetics, Local; D010120:Oxytocics; D016595:Misoprostol; D008012:Lidocaine