Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype.
Gonadoblastoma is a rare gonadal tumor with tumor cells arranged in nests surrounded by ovarian stroma containing Leydig or lutein-type cells. In 50% of the cases, there is an overgrowth of germ cells with progression to dysgerminoma. A case of gonadoblastoma with coexisting dysgerminoma developing in both ovaries of a 20-year-old girl who had increased abdominal girth is presented here. A pelvic mass measuring 20 x 14 cm was detected by pelvic ultrasonography. Bilateral salphingo-oophorectomy was performed. The histopathological report revealed bilateral gonadoblastoma with coexisting dysgerminoma. After surgery the patient received radiation and chemotherapy (BEP: bleomycin, etoposide, cisplatin) and was started on hormone replacement therapy. Five years and eight months after treatment, the patient is well and free of recurrence.
Yilmaz
Bulent
B
Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com
Gungor
Tayfun
T
Bayramoglu
Hatice
H
Soysal
Sunullah
S
Mollamahmutoglu
Leyla
L
D004407:Dysgerminoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D018238:Gonadoblastoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult