title: Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile.
abstract: With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of tert-butyl amine in an Ugi-type multicomponent reaction product, tert-butyl isocyanide as a useful convertible isonitrile has been explored for the first time affording access to molecular diversity of pharmaceutically-important polycyclic N-fused imidazo-heterocycles.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar (Mohali)-160062, Punjab, India. skguchhait@niper.ac.in
authors.forename: Sankar K
authors.initials: SK
authors.lastname: Guchhait
authors.forename: Chetna
authors.initials: C
authors.lastname: Madaan
mesh_terms: D002082:Butylamines / Q000737:chemistry*; D003500:Cyclization; D003640:Dealkylation; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
chemical_list: D002082:Butylamines; D009570:Nitriles; C099535:tert-butyl isocyanide; C025397:tert-butylamine