title: New cytotoxic oxygenated sterols from marine bryozoan Bugula neritina.
abstract: Two new oxygenated sterols, 3β,24(S)-dihydroxycholesta-5,25-dien-7-one and 3β,25-dihydroxycholesta-5,23-dien-7-one, were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC₅₀ values between 22.58 and 53.41 µg mL⁻¹.
authors.affiliation: Department of Pharmacy, Laboratory of Marine Drugs, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Jian-Tao
authors.initials: JT
authors.lastname: Chen
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Piao
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002013:Bryozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002783:Cholestenones; D054697:Cytostatic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C570264:3beta,24(S)-dihydroxycholesta-5,25-dien-7-one; C570265:3beta,25-dihydroxycholesta-5,23-dien-7-one; D000970:Antineoplastic Agents; D002783:Cholestenones; D054697:Cytostatic Agents; D013261:Sterols