title: Dose-dependent pharmacokinetics of SP-8203 in rats.
abstract: The pharmacokinetics of SP-8203, a potential protective agent for the treatment of cerebral infarction, were evaluated after its intravenous (10, 20 and 30 mg/kg) and oral (10, 20, 30 and 100 mg/kg) administration in rats. After the intravenous administration of SP-8203, the AUCs of SP-8203 were dose-dependent; the dose-normalized AUCs were significantly greater with increasing doses. After the oral administration of SP-8203, plasma concentrations of SP-8203 were much lower than those after intravenous administration. This could be due to considerable hepatic and intestinal metabolism and the high percent of the dose recovered from the gastrointestinal tract (including its contents and feces) at 24 h as unchanged drug.
authors.affiliation: Research Institute of Pharmaceutical Sciences, Seoul National University, South Korea.
authors.forename: Joo H
authors.initials: JH
authors.lastname: Lee
authors.forename: Young H
authors.initials: YH
authors.lastname: Choi
authors.forename: Jung H
authors.initials: JH
authors.lastname: Suh
authors.forename: Hee E
authors.initials: HE
authors.lastname: Kang
authors.forename: Tae H
authors.initials: TH
authors.lastname: Lee
authors.forename: Il H
authors.initials: IH
authors.lastname: Cho
authors.forename: Myung G
authors.initials: MG
authors.lastname: Lee
mesh_terms: D000081:Acetamides; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007262:Infusions, Intravenous; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D052999:Quinazolinones / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000081:Acetamides; D018696:Neuroprotective Agents; D052999:Quinazolinones; C552779:otaplimastat