Transport of inorganic mercury and methylmercury in target tissues and organs.
Owing to the prevalence of mercury in the environment, the risk of human exposure to this toxic metal continues to increase. Following exposure to mercury, this metal accumulates in numerous organs, including brain, intestine, kidneys, liver, and placenta. Although a number of mechanisms for the transport of mercuric ions into target organs were proposed in recent years, these mechanisms have not been characterized completely. This review summarizes the current literature related to the transport of inorganic and organic forms of mercury in various tissues and organs. This review identifies known mechanisms of mercury transport and provides information on additional mechanisms that may potentially play a role in the transport of mercuric ions into target cells.
Bridges
Christy C
CC
Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA. bridges_cc@mercer.edu
Zalups
Rudolfs K
RK
D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008628:Mercury / Q000737:chemistry / Q000493:pharmacokinetics*; D008767:Methylmercury Compounds / Q000493:pharmacokinetics*
D008767:Methylmercury Compounds; D008628:Mercury