title: A case of vaginal clear cell adenocarcinoma complicated with congenital anomalies of the genitourinary tract and metanephric remnant without prenatal diethylstilbestrol exposure.
abstract: Vaginal clear cell adenocarcinoma (CCA) is well known to be associated with prenatal diethylstilbestrol exposure. We present a vaginal CCA with congenital anomalies of the genitourinary tract without prenatal diethylstilbestrol exposure. A 54-year-old woman complained of a 3-month history of genital bleeding. The examination revealed CCA at the anterior vagina and congenital anomalies. An anterior pelvic exenteration was performed. Macroscopically, bicornuate uterus, vaginal septum and left ureteral agenesis were found. Microscopically, vaginal CCA coexisted with adenosis and both metanephric and mesonephric remnants. The vaginal CCA was supposed to derive from coexisting adenosis. The adenosis was also supposed to occur as a congenital basis, together with genitourinary tract anomalies. Relations between congenital anomalies of the genitourinary tract and vaginal adenocarcinoma were suspected, resultantly.
authors.affiliation: Gynecology Division, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. tak-uehara@hospital.chiba-u.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Uehara
authors.forename: Takashi
authors.initials: T
authors.lastname: Onda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasajima
authors.forename: Morio
authors.initials: M
authors.lastname: Sawada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kasamatsu
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014564:Urogenital Abnormalities / Q000150:complications*; D014625:Vaginal Neoplasms / Q000150:complications* / Q000473:pathology*