title: Four new phenanthrenes from Monomeria barbata Lindl.
abstract: Three biphenanthrene compounds (1-3) and a triphenanthrene compound (4), together with six known biphenanthrene compounds (5-10), were isolated from the tubers of Monomeria barbata Lindl. Their structures were elucidated on the basis of extensive spectroscopic analysis (1D-, 2D-NMR, and HR-ESI-MS). These four new compounds were tested in vitro for the cytotoxic activity against liver carcinoma (HepG-2), promyelocytic leukaemia (HL60), ovarian carcinoma (Skov-3) and epidermoid carcinoma (A431) cancer cell lines and the antioxidant activity in DPPH radical scavenging. Compounds 1-4 exhibited significant cytotoxic activity against HepG-2 and HL60 cell lines, and potent antioxidant activity in DPPH radical scavenging.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Yang
authors.forename: Le
authors.initials: L
authors.lastname: Cai
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Tai
authors.forename: Xianghui
authors.initials: X
authors.lastname: Zeng
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
mesh_terms: D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry*
chemical_list: D010616:Phenanthrenes