title: Development of PET radiopharmaceuticals and their clinical applications at the Positron Medical Center.
abstract: The Positron Medical Center has developed a large number of radiopharmaceuticals and 36 radiopharmaceuticals have been approved for clinical use for studying aging and geriatric diseases, especially brain functions. Positron emission tomography (PET) has been used to provide a highly advanced PET-based diagnosis. The current status of the development of radiopharmaceuticals, and representative clinical and methodological results are reviewed.
authors.affiliation: Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. ishiwata@pet.tmig.or.jp
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oda
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Muneyuki
authors.initials: M
authors.lastname: Sakata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nariai
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mishina
authors.forename: Masaya
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Masatomo
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Jun
authors.initials: J
authors.lastname: Toyohara
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001921:Brain / Q000098:blood supply; D005947:Glucose / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D043682:Receptor, Adenosine A1 / Q000502:physiology; D043705:Receptor, Adenosine A2A / Q000502:physiology; D018047:Receptors, Purinergic P1 / Q000502:physiology; D017480:Receptors, sigma / Q000502:physiology; D012039:Regional Blood Flow
chemical_list: D019275:Radiopharmaceuticals; D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1; D017480:Receptors, sigma; D005947:Glucose