[Study of the association between catalepsy, anxiety, aggression and depressive-like behavior in congenic mice].
Catalepsy is a natural passive defense strategy in animals and a syndrome of some mental di sorders. The main gene encoding catalepsy was located in mice on the distal fragment 55-75 cM of chromosome 13. Two congenic lines AKR.CBA-D13Mit76 and AKR.CBA-D 13Mit78 carrying the 55- to 71-, and 71- to 75-cM fragments of chromosome 13 transferred from the cataleptic strain CBA to the non-cataleptic strain AKR genome were created. It was shown that half of mice of congenic AKR.CBA-D 13 Mit76 line containing fragment 55-71 cM displayed pronounced catalepsy similar to the donor CBA strain. Also we demonstrated decreased of exploratory behavior in the open field test and an increased of intermale aggression of AKR.CBA-D 13Mit76 mice compared with the parent strain AKR. No differences were found in the forced swim test between AKR.CBA-D 13Mit76 and AKR mice. Behavior of congenic mice AKR.CBA-D 13Mit78 did not differ from the parent strain AKR in all used tests.
Kondaurova
E M
EM
Bazovkina
D V
DV
Kulikov
A V
AV
D000374:Aggression; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000503:physiopathology; D001522:Behavior, Animal; D002375:Catalepsy / Q000235:genetics / Q000503:physiopathology; D033481:Chromosomes, Mammalian / Q000235:genetics*; D003863:Depression / Q000235:genetics / Q000503:physiopathology; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D013045:Species Specificity