title: Reactive lymphoid hyperplasia of the liver associated with primary biliary cirrhosis.
abstract: BACKGROUND
  Although reactive lymphoid hyperplasia (RLH) can be found in various organs, including the gastrointestinal tract, orbit, lung, and skin, its occurrence in the liver is rare.
  
  
  METHODS
  We report the case of a 47-year-old RLH woman who was identified with RLH of the liver during clinical follow- up of primary biliary cirrhosis. The mass, found incidentally during a medical examination, appeared on ultrasonogram as a hypoechoic mass in the 7th segment of the liver. Further analyses using composed tomography, magnetic resonance imaging, and angiography suggested malignancy, and we performed lateral segmentectomy of the liver. Histologically, the tumor was composed of lymphoid follicles with germinal centers that expressed kappa and lambda light-chain B-cell markers at equal frequency, and no IgH gene rearrangements were detected in Southern blots. Based on these results, we identified the lesion as RLH.
  
  
  CONCLUSIONS
  We suggest that this diagnosis be taken into consideration in other cases involving a space-occupying liver mass associated with autoimmune disease.
authors.affiliation: Department of Gastroenterology Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Fukuo
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Shibuya
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fukumura
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Mizui
authors.forename: Jin Kan
authors.initials: JK
authors.lastname: Sai
authors.forename: Akihito
authors.initials: A
authors.lastname: Nagahara
authors.forename: Akira
authors.initials: A
authors.lastname: Tsukada
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Masafumi
authors.initials: M
authors.lastname: Suyama
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed