[The model of resting forms of mycobacteria for testing of drugs for latent forms of tuberculosis].
The new model of obtaining of ovoid resting forms Mycobacterium smegmatis, which are morphologically different from vegetative (rod-like) cells, was developed. Ovoid forms were characterized by a drastically decreased level of metabolic activity, an increased stability to heat processing and antibiotics action, and also by prolonged (more than 2 months) storage time preserving colony-forming ability. Obtained resting forms of mycobacteria may be used in test-systems for checking efficiency of new medical agents against latent forms of tuberculosis and determination of role of these of those genes in entering rest state.
Anuchin
A M
AM
Goncharenko
A V
AV
Galon
I V
IV
Demidenok
O I
OI
Kudykina
Iu K
IuK
Moĭsenovich
M M
MM
Muliukin
A L
AL
Kaprel'iants
A S
AS
D000904:Antibiotics, Antitubercular / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D024881:Drug Resistance, Bacterial; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D020102:Mycobacterium smegmatis / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure
D000904:Antibiotics, Antitubercular