The effect of testosterone upon the urate reabsorptive transport system in mouse kidney.
It is hypothesized that hyperuricemia in males is caused by androgen-induced urate reabsorptive transport system in the kidney. The expression of urate transporter 1 (Urat1), sodium-coupled monocarboxylate transporter 1 (Smct1) and glucose transporter 9 (Glut9) were investigated in orchiectomized mice with or without testosterone replacement. Testosterone enhanced mRNA and protein levels of Smct1 while those of Glut9 were attenuated. Although the mRNA level of Urat1 was enhanced by testosterone, the corresponding levels of Urat1 protein remained unaffected. Thus, the induction of Smct1 by testosterone is a candidate mechanism underlying hyperuricemia in males.
Hosoyamada
M
M
Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Takiue
Y
Y
Shibasaki
T
T
Saito
H
H
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D016022:Case-Control Studies; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism; D033461:Hyperuricemia / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D027501:Monocarboxylic Acid Transporters / Q000235:genetics / Q000378:metabolism; D009919:Orchiectomy; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D027981:Symporters / Q000235:genetics / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000099233:Monocarboxylate Transport Protein 1
D051246:Glucose Transport Proteins, Facilitative; D027501:Monocarboxylic Acid Transporters; D027361:Organic Anion Transporters; D012333:RNA, Messenger; D027981:Symporters; D013739:Testosterone; D014527:Uric Acid; D000099233:Monocarboxylate Transport Protein 1; C109687:Slc22a12 protein, mouse; C498775:Slc2a9 protein, mouse