[Computer simulations of the preautomatic pause in pacemaker cells of the sinoatrial node].
The duration of the preautomatic pause as a function of sinoatrial node, the type of pacemaker cells, acetylcholine concentration, the duration of high-frequency stimulation, and the conductivity of gap junctions has been studied. It was found that the preautomatic pause in peripheral pacemakers occurs at a higher concentration of acetylcholine as compared with central pacemakers. The dependence of the duration of the preautomatic pause on the gap junction conductivity is a nonlinear one.
Aliev
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D000109:Acetylcholine / Q000494:pharmacology; D001683:Biological Clocks; D003198:Computer Simulation; D004558:Electric Stimulation; D017629:Gap Junctions / Q000502:physiology; D008955:Models, Cardiovascular; D012849:Sinoatrial Node / Q000166:cytology / Q000502:physiology*; D013997:Time Factors
D000109:Acetylcholine