Pharmacological activities on Ephedra nebrodensis Tineo.
As a part of our endeavour to screen Mediterranean medicinal plants for various pharmacological activities, we evaluated antihistaminic, adaptogenic, anti-inflammatory, antinociceptive, hypotensive and locomotor properties, and antioxidant potential of Ephedra nebrodensis. (1)H-NMR spectroscopy was carried out to identify the plant metabolites, which confirmed the presence of ephedrinic skeleton alkaloids. The ethanol : acetone (1 : 1) extract exhibited dose-related antihistaminic, anti-inflammatory, antinociceptive, hypotensive, antioxidant and locomotor stimulant activity. The plant bears potential for further studies.
Ballero
Mauro
M
CoSMeSe, Department of Botanical Sciences, University of Cagliari, Italy.
Foddis
Caterina
C
Sanna
Cinzia
C
Scartezzini
Paolo
P
Poli
Ferruccio
F
Petitto
Valentina
V
Serafini
Mauro
M
Stanzione
Alessandra
A
Bianco
Armandodoriano
A
Serilli
Anna Maria
AM
Spina
Liliana
L
Longoni
Rosanna
R
Kasture
Sanjay
S
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D029789:Ephedra / Q000737:chemistry*; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D006633:Histamine Antagonists; D010936:Plant Extracts