title: Second line therapy for advanced pancreatic adenocarcinoma: where are we and where are we going? Highlights from the "2010 ASCO Annual Meeting". Chicago, IL, USA. June 4-8, 2010.
abstract: Most patients with adenocarcinoma of the pancreas present with locally advanced or metastatic disease. Although single agent gemcitabine is widely accepted as first-line therapy, there is no current standard of care for gemcitabine-refractory patients. Common second-line chemotherapy regimens included oxaliplatin and 5-FU/leucovorin (OFF), gemcitabine and oxaliplatin (GEMOX), oxaliplatin and capecitabine (XELOX), and irinotecan-oxaliplatin. At the 2010 American Society of Clinical Oncology (ASCO) Annual Meeting, several new second-line chemotherapy regimens were presented, including gemcitabine and oxaliplatin with imatinib, single agent nab-paclitaxel, and the combination of high-dose capecitabine with oxaliplatin and sorafenib. These abstracts provide exciting new directions for the treatment of gemcitabine-refractory advanced pancreatic cancer.
authors.affiliation: Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Brus
authors.forename: Muhammad Wasif
authors.initials: MW
authors.lastname: Saif
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant / Q000639:trends; D002641:Chicago; D003131:Combined Modality Therapy / Q000379:methods / Q000639:trends*; D003226:Congresses as Topic; D018450:Disease Progression; D006801:Humans; D008495:Medical Oncology / Q000379:methods / Q000639:trends*; D010190:Pancreatic Neoplasms / Q000628:therapy*; D012955:Societies, Medical / Q000458:organization & administration; D014481:United States