title: Evaluation of the CHOP cardiovascular score as a prognostic predictor of outcome in twin-twin transfusion syndrome after laser coagulation of placental vessels in a prospective cohort.
abstract: OBJECTIVE
  To investigate the prognostic value of cardiac function assessment by the previously reported CHOP (Children's Hospital of Philadelphia) cardiovascular score in twin-twin transfusion syndrome (TTTS).
  
  
  METHODS
  All consecutive monochorionic pregnancies presenting with TTTS over a 24-month period were evaluated by preoperative echocardiography before percutaneous laser coagulation of chorionic vessels. Each of the 12 items of the CHOP score was evaluated prospectively and the cardiovascular score was categorized into stages using previously published cut-offs. The outcome considered for this study was neonatal survival of neither, one or both twins.
  
  
  RESULTS
  In total, 215 pregnancies were enrolled. Due to technical issues, CHOP evaluation was incomplete in 16% of cases and follow-up was unavailable in 12%. Overall, there was a significant relationship between the CHOP score and the Quintero staging system, although this relationship was significantly reduced when parameters used in the Quintero system were removed from the CHOP score. Based upon neonatal survival, the CHOP score did not show any prognostic value regarding overall pregnancy outcome or individual recipient survival.
  
  
  CONCLUSIONS
  Cardiac function assessment using the CHOP score is not of clinical use as a prognostic marker in TTTS. This suggests that cardiac function may not be of interest for preoperative staging when laser coagulation is the first-line treatment, other than to confirm the diagnosis of TTTS requiring surgery.
authors.affiliation: Department of Obstetrics and Maternal-Fetal Medicine, GHU Necker-Enfants Malades, University Paris Descartes, Paris, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Stirnemann
authors.forename: B
authors.initials: B
authors.lastname: Nasr
authors.forename: F
authors.initials: F
authors.lastname: Proulx
authors.forename: M
authors.initials: M
authors.lastname: Essaoui
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
mesh_terms: D004452:Echocardiography / Q000379:methods; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D005330:Fetofetal Transfusion / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D017075:Laser Coagulation / Q000379:methods; D010920:Placenta / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D011446:Prospective Studies; D014427:Twins; D016216:Ultrasonography, Prenatal