Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring.
High S(N)2' selectivity in the allylic substitution of cyclohexylidene ethyl picolinates with copper reagents prepared from RMgBr and CuBr.Me(2)S was realized by addition of ZnX(2) (X = I, Br, Cl). Furthermore, ZnX(2) accelerated the reaction with the bulky iPr reagent.
Kaneko
Yuki
Y
Department of Biomolecular Engineering, Tokyo Institute of Technology, Japan.
Kiyotsuka
Yohei
Y
Acharya
Hukum P
HP
Kobayashi
Yuichi
Y
D002244:Carbon / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D003510:Cyclohexanes / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry
D003510:Cyclohexanes; D010848:Picolinic Acids; C506365:Cyclohexane; D002244:Carbon; D003300:Copper