Antiviral properties of antineoplastic drugs. From herpes simplex-1 disappearance to a wide antiviral action: a serendipity case report.
Herein we report the clinical case of a 46 year old female affected by lung cancer and cerebral metastases who showed, one month after the beginning of an oncologic therapy with vinorelbine and cisplatin, the complete remission of periodic (every 15 days) recurrences of herpetic mouth lesions. More than one year after the disappearance of the herpetic lesions, no further evidence of them were found. Subsequently, specific laboratory investigations, together with another case report that is presently in process, showed that vinorelbine, aside from its well known antineoplastic properties, also exerts a powerful antiviral action.
Debernardis
Angela
A
Dept. of Pharmacology and Human Physiology, University of Bari, Bari, Italy.
Alfonsi
Gina
G
Santacroce
Luigi
L
Bottalico
Lucrezia
L
Sabatini
Rosa
R
Flace
Paolo
P
Vermesan
Dinu
D
Auteri
Pietro
P
Sisto
Giuseppe
G
Cagiano
Raffaele
R
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D015897:Comorbidity; D005260:Female; D006560:Herpes Labialis / Q000188:drug therapy* / Q000453:epidemiology; D018259:Herpesvirus 1, Human; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077235:Vinorelbine
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D014747:Vinblastine; D000077235:Vinorelbine