The association of chronic kidney disease-mineral bone disorder and cardiovascular risk.
Chronic kidney disease-mineral bone disorder (CKD-MBD) is a multifaceted definition used to help describe the systemic derangement of mineral bone metabolism in renal disease. This was previously referred to, rather simplistically, as 'renal osteodystrophy' or 'renal bone disease'. In this review, we will try to show the evidence relating these factors to cardiovascular morbidity and mortality and give some evidence as to the mechanisms for this. The treatments used for this condition are also integral to the increased cardiovascular mortality seen in renal patients and a summary of these effects will also be covered.
Eddington
Helen
H
Salford Royal Foundation NHS Trust, Renal Department, Vascular Research Group, Salford, M6 8HD, UK. heddington@doctors.org.uk
Kalra
Philip A
PA
D016723:Bone Remodeling / Q000502:physiology; D002114:Calcinosis / Q000150:complications / Q000451:nursing / Q000503:physiopathology; D002118:Calcium / Q000097:blood; D002318:Cardiovascular Diseases / Q000401:mortality / Q000451:nursing* / Q000503:physiopathology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000401:mortality / Q000451:nursing* / Q000503:physiopathology*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000451:nursing* / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000502:physiology; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects / Q000451:nursing; D015996:Survival Rate; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium