title: Acute megakaryocytic leukemia (AMKL,FAB;M7) with Beckwith-Wiedemann syndrome.
abstract: Beckwith-Wiedemann syndrome (BWS) is characterized by an accumulation of multiple congenital anomalies. Although patients with BWS are known to have a higher incidence of embryonal tumors, there has been no reports associated with acute leukemia. This report describes the case of a patient with BWS who developed Acute Megakaryocytic Leukemia (AMKL,FAB;M7). Because most patients with BWS present gigantism, the therapy-related toxicity of chemotherapy can be a very serious problem. This patient exhibited no therapy-related toxicity after chemotherapy, suggesting that acute leukemia with BWS may not require a reduction in dosage.
authors.affiliation: Division of Pediatrics, Department of Showa University Fujigaoka Hospital, Aoba-ku, Yokohama, Kanagawa, Japan. shohei-y@showa-university-fujigaoka.gr.jp
authors.forename: Shohei
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Toyama
authors.forename: Hitomi
authors.initials: H
authors.lastname: Yatsuki
authors.forename: Ken
authors.initials: K
authors.lastname: Higashimoto
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Soejima
authors.forename: Keiichi
authors.initials: K
authors.lastname: Isoyama
mesh_terms: D001506:Beckwith-Wiedemann Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology*; D008297:Male