A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.
Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively.
Liang
Yong-hong
YH
School of Pharmaceutical Sciences, Peking University, Beijing, PR China.
Wang
Wei
W
Yu
Si-wang
SW
Ye
Min
M
He
Xiang-hui
XH
Gong
Ning-bo
NB
Lu
Yang
Y
Khan
Ikhlas A
IA
Guo
De-an
DA
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D029621:Polypodiaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes