Capsules with silver nanoparticle enrichment subdomains and their antimicrobial properties.
The fabrication of polyelectrolyte multilayer capsules with controllable submicron-sized subdomains and the in situ synthesis of silver nanoparticles are reported. Because poly(acrylic acid) (PAA) is released from the shell of the capsules in the dissolution process of sacrificial cores, the remaining poly(4-vinylpyridine) (PVP) forms subdomains of spheres with controllable sizes, which can be tuned by the number of PVP/PAA bilayers. This creates capsules with special surface morphology and enables the in situ synthesis of Ag nanoparticles within the PVP subdomains on the shell of capsules. In addition, the in-situ formed Ag nanoparticles can be mostly released from PVP subdomains of capsules in pH 2.0 solution, whereas they are stable in neutral solution. These specially designed capsules containing Ag nanoparticles can be used as antimicrobial materials and potentially benefit remote drug release by laser activation.
Wang
Anhe
A
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing 100190, PR China.
Cui
Yue
Y
Yang
Yang
Y
Li
Junbai
J
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002214:Capsules / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011145:Polyvinyls / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000890:Anti-Infective Agents; D002214:Capsules; D011145:Polyvinyls; C019535:poly(4-vinylpyridine); D012834:Silver