Unsuccessful treatment of recalcitrant cutaneous discoid lupus erythematosus with photodynamic therapy.
Discoid lupus erythematosus (DLE) can be a therapeutic challenge. Antimalarials and topic steroids are the first-line standard therapies, while systemic steroids, immunomodulators (as azathioprine, methotrexate, cyclosporine), retinoids (acitretin), thalidomide, auranofin and dapsone are used as second-line therapies. We report two patients with recalcitrant DLE who were treated with three and two sessions of 5-aminolevulinic photodynamic therapy without an improvement and with a bad tolerance to the therapy.
Romero-Maté
Alberto
A
Department of Dermatology, Hospital de Fuenlabrada, Madrid, Spain.
Castaño-Suárez
Esther
E
García-Donoso
Carmen
C
Martínez-Morán
Cristina
C
Meseguer-Yebra
Carmen
C
Borbujo
Jesús
J
D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D016896:Treatment Outcome