title: The endocrine regulation network of growth hormone synthesis and secretion in fish: emphasis on the signal integration in somatotropes.
abstract: In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pituitary somatotropes when differentiating and integrating the signals from these regulators at the cellular and intracellular level is essential for understanding the endocrine regulation network of growth hormone synthesis and secretion in fish. This paper discusses recent advances in the action mechanisms of GH regulation factors, including the neuroendocrine regulators, pituitary level factors and peripheral factors, primarily involved in their receptor systems as well as in post-receptor signal transduction pathways.
authors.affiliation: State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and the Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. lsslws@mail.sysu.edu.cn
authors.forename: WenSheng
authors.initials: W
authors.lastname: Li
authors.forename: HaoRan
authors.initials: H
authors.lastname: Lin
mesh_terms: D000818:Animals; D004703:Endocrine System / Q000378:metabolism*; D005399:Fishes / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D019382:Human Growth Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D009490:Neurosecretory Systems / Q000378:metabolism; D036361:Peptide Hormones / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D006728:Hormones; D009479:Neuropeptides; D036361:Peptide Hormones; D019382:Human Growth Hormone; D013006:Growth Hormone