Dengue and chikungunya infections in travelers.
OBJECTIVE
Dengue and chikungunya are arboviruses that have caused major outbreaks and infected travelers, and both can be associated with fever and rash. We review the recent epidemiology of dengue and chikungunya infections and discuss their clinical presentations, diagnosis, treatment, and prevention. We highlight the findings in travelers.


RESULTS
Globally dengue is one of the most common infections associated with travel, and incidence has increased in the Americas in recent years, especially in Brazil. Chikungunya has caused dramatic outbreaks in the Indian Ocean islands since 2004, and has spread to south and south-east Asia. Dengue virus and chikungunya virus also possess the potential to cause autochthonous transmission in temperate regions of developed countries due to the presence of the vector mosquito, Aedes albopictus. Such an outbreak (chikungunya infection) did occur in 2007 in Italy. A mutation in chikungunya virus (A226V) appears to improve virus survival in Aedes albopictus and also increase its virulence.


CONCLUSIONS
The findings assist in differentiating dengue and chikungunya from other acute febrile illnesses and from each other. The findings also illustrate potential outbreaks in nonendemic countries, important toward developing control and prevention strategies.
Chen
Lin H
LH
Travel Medicine Center, Mount Auburn Hospital, Cambridge, Massachusetts, USA. lchen@hms.harvard.edu
Wilson
Mary E
ME
D000330:Aedes / Q000821:virology; D018354:Alphavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D000569:Americas / Q000453:epidemiology; D000818:Animals; D001208:Asia / Q000453:epidemiology; D002646:Chikungunya virus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D003715:Dengue / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D004199:Disease Vectors; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D014195:Travel; D014774:Virulence