title: [Brazilian guidelines for the diagnosis of narcolepsy].
abstract: This manuscript contains the conclusion of the consensus meeting on the diagnosis of narcolepsy based on the review of Medline publications between 1980-2010. Narcolepsy is a chronic disorder with age at onset between the first and second decade of life. Essential narcolepsy symptoms are cataplexy and excessive sleepiness. Cataplexy is defined as sudden, recurrent and reversible attacks of muscle weakness triggered by emotions. Accessory narcolepsy symptoms are hypnagogic hallucinations, sleep paralysis and nocturnal fragmented sleep. The clinical diagnosis according to the International Classification of Sleep Disorders is the presence of excessive sleepiness and cataplexy. A full in-lab polysomnography followed by a multiple sleep latency test is recommended for the confirmation of the diagnosis and co-morbidities. The presence of two sleep-onset REM period naps in the multiple sleep latency test is diagnostic for cataplexy-free narcolepsy. A positive HLA-DQB1*0602 with lower than 110pg/mL level of hypocretin-1 in the cerebrospinal fluid is required for the final diagnosis of cataplexy- and sleep-onset REM period -free narcolepsy.
authors.affiliation: Hospital das Clínicas, Universidade de São Paulo, SP, Brasil. piero.ops@terra.com.br
authors.forename: Flávio
authors.initials: F
authors.lastname: Alóe
authors.forename: Rosana Cardoso
authors.initials: RC
authors.lastname: Alves
authors.forename: John F
authors.initials: JF
authors.lastname: Araújo
authors.forename: Alexandre
authors.initials: A
authors.lastname: Azevedo
authors.forename: Andrea
authors.initials: A
authors.lastname: Bacelar
authors.forename: Márcio
authors.initials: M
authors.lastname: Bezerra
authors.forename: Lia Rita Azeredo
authors.initials: LR
authors.lastname: Bittencourt
authors.forename: Guilherme
authors.initials: G
authors.lastname: Bustamante
authors.forename: Tânia Aparecida Marchiori de Oliveira
authors.initials: TA
authors.lastname: Cardoso
authors.forename: Alan L
authors.initials: AL
authors.lastname: Eckeli
authors.forename: Regina Maria França
authors.initials: RM
authors.lastname: Fernandes
authors.forename: Leonardo
authors.initials: L
authors.lastname: Goulart
authors.forename: Márcia
authors.initials: M
authors.lastname: Pradella-Hallinan
authors.forename: Rosa
authors.initials: R
authors.lastname: Hasan
authors.forename: Heidi Haueisen
authors.initials: HH
authors.lastname: Sander
authors.forename: Luciano Ribeiro
authors.initials: LR
authors.lastname: Pinto
authors.forename: Maria Cecília
authors.initials: MC
authors.lastname: Lopes
authors.forename: Gisele Richter
authors.initials: GR
authors.lastname: Minhoto
authors.forename: Walter
authors.initials: W
authors.lastname: Moraes
authors.forename: Gustavo Antônio
authors.initials: GA
authors.lastname: Moreira
authors.forename: Daniela
authors.initials: D
authors.lastname: Pachito
authors.forename: Mário
authors.initials: M
authors.lastname: Pedrazolli
authors.forename: Dalva
authors.initials: D
authors.lastname: Poyares
authors.forename: Lucila
authors.initials: L
authors.lastname: Prado
authors.forename: Geraldo
authors.initials: G
authors.lastname: Rizzo
authors.forename: R Nonato
authors.initials: RN
authors.lastname: Rodrigues
authors.forename: Israel
authors.initials: I
authors.lastname: Roitman
authors.forename: Ademir Baptista
authors.initials: AB
authors.lastname: Silva
authors.forename: Stella Márcia Azevedo
authors.initials: SM
authors.lastname: Tavares
mesh_terms: D001938:Brazil; D003937:Diagnosis, Differential; D006801:Humans; D009290:Narcolepsy / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics