title: Evolving role of 18F-FDG-PET/CT for the body tumor and metastases in pediatrics.
abstract: (18)F-FDG-positron emission tomography-computerized tomography ((18)F-FDG-PET/CT) scan is an important imaging tool which may provide both functional and anatomical information in a single diagnostic test. It has the potential to be a valuable tool in the noninvasive evaluation and monitoring of pediatric tumors including the metastases because (18)fluorodeoxyglucose ((18)F-FDG) is a glucose analogue that concentrates in areas of active metabolic activity. This review provides an update on functional and metabolic imaging approaches for assessment and management of the body tumor and metastases in pediatrics using a combined whole body (18)F-FDG-PET/CT scanners. We discuss the benefits include improved pediatric patients' outcome facilitated by staging and monitoring of disease and better treatment planning. It is worth to concern the preparation of children undergoing PET studies and radiation dosimetry and its implications for family and caregivers. It is important to consider the normal distribution of (18)FDG in children, common variations of the normal distribution. We show some of our cases that most tumors in children accumulate and retain FDG, allowing high-quality images of their distribution and pathophysiology either at the primary site as well as in the areas of metastatic disease.
authors.affiliation: Department of Radiology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, No. 5 Hai Yun Cang Beijing 100700, PR China. guangchen1@gmail.com
authors.forename: Zhengguang
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Qiaohong
authors.initials: Q
authors.lastname: Ouyang
authors.forename: Tong
authors.initials: T
authors.lastname: Yu
mesh_terms: D019788:Fluorodeoxyglucose F18; D005544:Forecasting; D006801:Humans; D008207:Lymphatic Metastasis; D009369:Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods* / Q000639:trends; D019275:Radiopharmaceuticals; D013382:Subtraction Technique / Q000639:trends; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000639:trends; D051598:Whole Body Imaging / Q000379:methods* / Q000639:trends
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18