title: Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice.
abstract: Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus.
authors.affiliation: Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Lukas
authors.initials: L
authors.lastname: Wanka
authors.forename: Julie
authors.initials: J
authors.lastname: Blanchard
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Muhammad Omar
authors.initials: MO
authors.lastname: Chohan
authors.forename: Khalid
authors.initials: K
authors.lastname: Iqbal
authors.forename: Inge
authors.initials: I
authors.lastname: Grundke-Iqbal
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000375:Aging / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D018891:Dentate Gyrus / Q000187:drug effects; D053605:Leukemia Inhibitory Factor / Q000378:metabolism; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009414:Nerve Growth Factors / Q000737:chemistry / Q000494:pharmacology*; D055495:Neurogenesis / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D021641:Recognition, Psychology / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D013569:Synapses / Q000187:drug effects* / Q000378:metabolism
chemical_list: D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D009414:Nerve Growth Factors; D009842:Oligopeptides; C000608789:P021 peptide; D000218:Adamantane