title: How much does phase resetting contribute to event-related EEG abnormalities in schizophrenia?
abstract: OBJECTIVE
  Patients suffering from schizophrenia demonstrate impaired low frequency electrophysiological responses to stimuli, but it remains unclear whether these abnormalities arise from phase resetting of ongoing oscillations, new phase-locked (evoked) activity or non-phase-locked (induced) activity. Our goal is to clarify the contribution of each of these three processes to the impairment of neural activity during information processing in schizophrenia, by using statistics that do not confound increases in the mean post-stimulus signal with phase resetting.
  
  
  METHODS
  Thirty-four male schizophrenia patients and 34 healthy matched controls performed an auditory oddball task. We applied the analysis procedure developed by Martinez-Montes et al. based on complex-valued wavelet transform to event-related signal elicited by target stimuli.
  
  
  RESULTS
  The largest abnormalities were found for phase-locked delta (1-4 Hz) and non-phase-locked theta (4-8 Hz). Delta phase resetting was moderately impaired and related to symptoms of disorganization. It also predicted evoked theta signal.
  
  
  CONCLUSIONS
  The substantial reduction of both evoked and induced oscillatory activity in schizophrenia indicates diminished recruitment of brain circuits engaged not only in stimulus-locked perceptual processing but also in more extensive processing less tightly time locked to the stimulus. Although reduced phase resetting makes a lesser contribution, it indicates a deficit in the ability to harness ongoing electrical activity.
authors.affiliation: Division of Psychiatry, School of Community Health Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG72UH, UK. mcxkd4@nottingham.ac.uk
authors.forename: Kathrin
authors.initials: K
authors.lastname: Doege
authors.forename: Marije
authors.initials: M
authors.lastname: Jansen
authors.forename: Pavan
authors.initials: P
authors.lastname: Mallikarjun
authors.forename: Elizabeth Bruce
authors.initials: EB
authors.lastname: Liddle
authors.forename: Peter Francis
authors.initials: PF
authors.lastname: Liddle
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003265:Contingent Negative Variation / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D011571:Psychoacoustics; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D013057:Spectrum Analysis; D013997:Time Factors; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents