title: Plasma proANP1-98 response during high altitude stress: effect of age and ethnicity.
abstract: OBJECTIVE
  Acclimatization to high altitude (HA) is accompanied by decrease in plasma atrial natriuretic peptide (ANP). On the other hand, circulating levels of the hormone are known to be influenced by age and ethnicity. The impact of these factors on ANP response during prolonged HA exposure remains unexplored. Hence, this study was conducted to examine possible age and ethnic variation in plasma proANP(1-98) levels in men after 3 to 4 weeks at HA.
  
  
  METHODS
  Lowlanders (LL) were studied at sea level (SL) and after 3 to 4 weeks at an altitude of approximately 4500 m. The LL group comprised Rajput (n = 48), Gorkha (n = 40), and South Indian (n = 43) ethnicities. Another group of HA natives (Ladakhi, n = 40) were studied at approximately 4500 m only. Subjects were between 20 and 50 years of age. Estimation of plasma proANP(1-98) and biochemical, hematologic, and physiologic evaluation was done.
  
  
  RESULTS
  In LL at HA, proANP(1-98) levels decreased (P < .001); plasma arginine vasopressin decreased (P < .05 in Rajputs and South Indians); and total protein, hemoglobin, and hematocrit increased (P < .05). Heart rate increased (P < .05), whereas arterial oxygen saturation decreased (P < .05) in all LL at HA. Ethnicity but not age variation in proANP(1-98) was observed under HA stress. In HA natives, plasma proANP(1-98) was higher than LL at HA and did not exhibit any age variation.
  
  
  CONCLUSIONS
  Plasma proANP(1-98) levels, reflecting medium-term ANP secretion, decrease during prolonged exposure to HA in LL. This is due to diuresis leading to plasma volume reduction that occurs during the acclimatization process. Ethnicity but not age variation is associated with plasma proANP(1-98) under HA stress.
authors.affiliation: Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Sachidhanandam
authors.forename: Som Nath
authors.initials: SN
authors.lastname: Singh
authors.forename: Yogendra Kumar
authors.initials: YK
authors.lastname: Sharma
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Salhan
authors.forename: Uday Sankar
authors.initials: US
authors.lastname: Ray
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000097:blood; D000531:Altitude; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005006:Ethnicity; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D009320:Atrial Natriuretic Factor; D010100:Oxygen