Rab6 and myosin II at the cutting edge of membrane fission.
Rab GTPases regulate the dynamics of transport carriers by participating in their translocation across the cytoplasm, and in their docking and fusion with acceptor compartments. An interaction between Golgi-associated Rab6 and myosin II has now been shown to regulate the fission of Rab6-positive carriers, illuminating a previously unappreciated role for Rab6 and the actomyosin system in carrier biogenesis.
Valente
Carmen
C
Polishchuk
Roman
R
De Matteis
Maria Antonietta
MA
D000199:Actins / Q000378:metabolism; D000205:Actomyosin / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008954:Models, Biological; D024462:Myosin Type II / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D000199:Actins; C094135:Rab6 protein; D000205:Actomyosin; D024462:Myosin Type II; D020691:rab GTP-Binding Proteins