Continuous glucose monitoring in youth with type 1 diabetes: 12-month follow-up of the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial.
BACKGROUND
The use of continuous glucose monitoring (CGM) in the pediatric population is not well characterized. We have evaluated the use of CGM over a 12-month interval in youth with type 1 diabetes (TID) and have provided a description of CGM use.


METHODS
Eighty subjects 8-17 years old with T1D and baseline hemoglobin A1c (HbA1c) >or=7.0% used CGM as part of a 6-month randomized trial and subsequent 6-month extension study. Outcomes included frequency of CGM use, HbA1c levels, rate of severe hypoglycemia, and a CGM satisfaction scale.


RESULTS
Seventy-six (95%) of 80 subjects were using CGM after 6 months (median use = 5.5 days/week) compared with 67 (84%) after 12 months (median use = 4.0 days/week). The 17 subjects using CGM >or=6 days/week in month 12 had substantially greater improvement from baseline in HbA1c than did the 63 subjects using CGM <6 days/week in month 12 (mean change - 0.8 +/- 0.6% vs. +0.1 +/- 0.7%, P < 0.001). They also reported greater satisfaction with use of CGM (P = 0.001). The incidence of severe hypoglycemic events was low during the 12 months of the study irrespective of the amount of CGM use.


CONCLUSIONS
In youth with T1D, frequency of use decreases over time. Individuals who use CGM on a near-daily basis can have substantial improvement in glycemic control.
Chase
H Peter
HP
Barbara Davis Center, Denver, Colorado, USA. jdrfapp@jaeb.org
Beck
Roy W
RW
Xing
Dongyuan
D
Tamborlane
William V
WV
Coffey
Julie
J
Fox
Larry A
LA
Ives
Brett
B
Keady
Joyce
J
Kollman
Craig
C
Laffel
Lori
L
Ruedy
Katrina J
KJ
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018670:Monitoring, Ambulatory / Q000379:methods*; D017060:Patient Satisfaction; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
D001786:Blood Glucose; D006442:Glycated Hemoglobin