Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.
Clancy
Kathleen W
KW
Department of Chemistry, Duke University, Durham, NC, USA.
Melvin
Jeffrey A
JA
McCafferty
Dewey G
DG
D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000201:enzymology*; D013379:Substrate Specificity / Q000187:drug effects / Q000502:physiology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D019881:Aminoacyltransferases; D003546:Cysteine Endopeptidases