title: Blood pressure control in chronic kidney disease: is less really more?
abstract: BP control is critical in the treatment of patients with chronic kidney disease. Recent guidelines now recommend a BP goal of <130/80 mmHg. Clinical trials using a randomized, intention-to-treat design have not established the benefits of this goal; rather, observational data and secondary or subgroup analyses drove the development of the new guidelines. A variety of observations suggest potential adverse events associate with achieving too low a BP in patients with chronic kidney disease, and ongoing randomized trials will have to establish the benefits or risks of meeting this goal.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, S-2332 Medical Center North, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2372, USA. julia.lewis@vanderbilt.edu
authors.forename: Julia B
authors.initials: JB
authors.lastname: Lewis
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology*; D002908:Chronic Disease; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control; D007674:Kidney Diseases / Q000503:physiopathology*; D017410:Practice Guidelines as Topic
chemical_list: D000959:Antihypertensive Agents