title: Intraluminal polypoid metastasis of renal cell carcinoma in gallbladder mimicking gallbladder polyp.
abstract: BACKGROUND
  Metastatic renal cell carcinoma (RCC) in gallbladder is rare with only 18 cases published in the English literature.
  
  
  OBJECTIVE
  To review the clinicopathologic characteristics of metastatic RCC in gallbladder and to correlate the findings with clinical outcomes.
  
  
  METHODS
  We report 4 additional cases of intraluminal polypoid metastasis of RCC in gallbladder and reviewed all reported cases, to our knowledge, of metastatic RCC in gallbladder in the English literature.
  
  
  RESULTS
  Most of the patients (19 of 22; 86%) were men. The ages at presentation ranged from 39 to 84 years with a median age of 61.5 years. All cases showed an intraluminal polypoid/pedunculated mucosal mass mimicking a gallbladder polyp. Histologically, all cases were clear cell RCC with most of the tumors either confined to gallbladder mucosa (67%) or involved both mucosa and muscular layer (27%). The longest interval between nephrectomy and the development of gallbladder metastasis was 27 years.
  
  
  CONCLUSIONS
  Metastatic clear cell RCC should be considered in the differential diagnosis of polypoid lesion of the gallbladder with clear cell morphology. Solitary metastasis of RCC in gallbladder correlated with better survival, and simple cholecystectomy for solitary metastatic RCC may provide patients with favorable long-term survival.
authors.affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: Xueping
authors.initials: X
authors.lastname: Fang
authors.forename: Nilesh
authors.initials: N
authors.lastname: Gupta
authors.forename: Steven S
authors.initials: SS
authors.lastname: Shen
authors.forename: Pheroze
authors.initials: P
authors.lastname: Tamboli
authors.forename: Chusilp
authors.initials: C
authors.lastname: Charnsangavej
authors.forename: Asif
authors.initials: A
authors.lastname: Rashid
authors.forename: Huamin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D005705:Gallbladder Diseases / Q000175:diagnosis*; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography