Dual oxidase in mucosal immunity and host-microbe homeostasis.
Mucosal epithelia are in direct contact with microbes, which range from beneficial symbionts to pathogens. Accordingly, hosts must have a conflicting strategy to combat pathogens efficiently while tolerating symbionts. Recent progress has revealed that dual oxidase (DUOX) plays a key role in mucosal immunity in organisms that range from flies to humans. Information from the genetic model of Drosophila has advanced our understanding of the regulatory mechanism of DUOX and its role in mucosal immunity. Further investigations of DUOX regulation in response to symbiotic or non-symbiotic bacteria and the in vivo consequences in host physiology will give a novel insight into the microbe-controlling system of the mucosa.
Bae
Yun Soo
YS
Division of Life and Pharmaceutical Science, Department of Life Science, Department of Bioinspired Science, Ewha Woman's University, Seoul 120-750, South Korea.
Choi
Myoung Kwon
MK
Lee
Won-Jae
WJ
D000818:Animals; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D019255:NADPH Oxidases / Q000276:immunology* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D019255:NADPH Oxidases