[Expressions of surviving, MMP2, TIMP1, CD44 and nm23 of two tumors originating from different immunosurveillance in the same patient].
OBJECTIVE
To explore the differences in the survival, adhesion and diffusion capacity between different carcinomas originating from different immunosurveillance in the same patient.


METHODS
The expressions of survivin, MMP2, TIMP1, CD44, and nm23 proteins were detected immunohistochemically in a patient with acute lymphoblastic leukemia and lymphoma after allogeneic blood stem cell transplantation.


RESULTS
Survivin, MMP2, TIMP1, CD44, and nm23 proteins were positive in acute lymphoblastic leukemia samples obtained before transplantation and negative in the lymphoma tissue occurring after the transplantation.


CONCLUSIONS
The expressions of survivin, MMP2, TIMP1, CD44, and nm23 proteins vary between the two carcinomas originating from different immunosurveillance in the same patient.
Li
Hui-ling
HL
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lihuiling1975@126.com
Xiang
Zheng
Z
Zhao
Tong
T
D000328:Adult; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism; D016609:Neoplasms, Second Primary / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D000077022:Survivin; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*
C107489:BIRC5 protein, human; C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D051034:Inhibitor of Apoptosis Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D000077022:Survivin; C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C517938:NME1 protein, human; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2