title: A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.
abstract: Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively.
authors.affiliation: School of Pharmaceutical Sciences, Peking University, Beijing, PR China.
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Liang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Si-wang
authors.initials: SW
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Ye
authors.forename: Xiang-hui
authors.initials: XH
authors.lastname: He
authors.forename: Ning-bo
authors.initials: NB
authors.lastname: Gong
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: De-an
authors.initials: DA
authors.lastname: Guo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D029621:Polypodiaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes