Mechanisms of vascular aging: new perspectives.
This review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial oxidative stress, inflammation, and development of vascular disease in the elderly patients; and provides a landscape of molecular mechanisms involved in cellular oxidative stress resistance, which could be targeted for the prevention or amelioration of unsuccessful vascular aging. Practical interventions for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the effects of anti-inflammatory treatments, regular exercise, dietary interventions, and caloric restriction mimetics.
Ungvari
Zoltan
Z
Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA. zoltan-ungvari@ouhsc.edu
Kaley
Gabor
G
de Cabo
Rafael
R
Sonntag
William E
WE
Csiszar
Anna
A
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000503:physiopathology; D001808:Blood Vessels / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D031204:Caloric Restriction; D004730:Endothelium, Vascular / Q000503:physiopathology; D015444:Exercise; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D000077185:Resveratrol; D013234:Stem Cells / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology; D014652:Vascular Diseases / Q000188:drug therapy / Q000503:physiopathology
D013267:Stilbenes; D000077185:Resveratrol