"Clickable", polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions.
A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide-alkyne cycloaddition (a "click" reaction) are optimized for rapid attachment of azides with controlled composition onto the liposomes.
Kumar
Amit
A
Department of Chemistry, University of Houston, Houston, TX 77204, USA.
Erasquin
Uriel J
UJ
Qin
Guoting
G
Li
King
K
Cai
Chengzhi
C
D000480:Alkynes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry; D053279:Polyynes / Q000737:chemistry; D051381:Rats
D000480:Alkynes; D001386:Azides; D008081:Liposomes; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D003300:Copper