title: Compensation of motion artifacts in catheter-based optical frequency domain imaging.
abstract: A novel heterodyne Doppler interferometer method for compensating motion artifacts caused by cardiac motion in intracoronary optical frequency domain imaging (OFDI) is demonstrated. To track the relative motion of a catheter with regard to the vessel, a motion tracking system is incorporated with a standard OFDI system by using wavelength division multiplexing (WDM) techniques. Without affecting the imaging beam, dual WDM monochromatic beams are utilized for tracking the relative radial and longitudinal velocities of a catheter-based fiber probe. Our results demonstrate that tracking instantaneous velocity can be used to compensate for distortion in the images due to motion artifacts, thus leading to accurate reconstruction and volumetric measurements with catheter-based imaging.
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital 50 Blossom Street, BAR-7, Boston Massachusetts 02114, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Ha
authors.forename: M
authors.initials: M
authors.lastname: Shishkov
authors.forename: M
authors.initials: M
authors.lastname: Colice
authors.forename: W Y
authors.initials: WY
authors.lastname: Oh
authors.forename: H
authors.initials: H
authors.lastname: Yoo
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: G J
authors.initials: GJ
authors.lastname: Tearney
authors.forename: B E
authors.initials: BE
authors.lastname: Bouma
mesh_terms: D000818:Animals; D016477:Artifacts; D017023:Coronary Angiography / Q000295:instrumentation*; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D007368:Interferometry / Q000295:instrumentation*; D009038:Motion; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity