title: A large strain material model for soft tissues with functionally graded properties.
abstract: The reaction of articular cartilage and other soft tissues to mechanical loads has been characterized by coupled hydraulic (H) and mechanical (M) processes. An enhanced biphasic material model is presented, which may be used to describe the load response of soft tissue. A large-strain numerical approach of HM coupled processes has been applied. Physical and geometrical nonlinearities, as well as anisotropy and intrinsic rate-dependency of the solid skeleton have been realized using a thermodynamically consistent approach. The presented material model has been implemented into the commercially available finite element code MSC MARC. Initial verification of the model has been conducted analytically in tendonlike structures. The poroelastic and intrinsic viscoelastic features of the model were compared with the experimental data of an unconfined compression test of agarose hydrogel. A recent example from the area of cartilage research has been modeled, and the mechanical response was compared with cell viability. All examples showed good agreement between numerical and analytical/experimental results.
authors.affiliation: Department of Environmental Informatics, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, D-04318 Leipzig, Germany.
authors.forename: Uwe-Jens
authors.initials: UJ
authors.lastname: Görke
authors.forename: Hubert
authors.initials: H
authors.lastname: Günther
authors.forename: Thomas
authors.initials: T
authors.lastname: Nagel
authors.forename: Markus A
authors.initials: MA
authors.lastname: Wimmer
mesh_terms: D016880:Anisotropy; D002356:Cartilage / Q000502:physiology*; D002358:Cartilage, Articular / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D009141:Musculoskeletal System