title: Natural history of small colorectal protuberant adenomas.
abstract: Most previous studies of the natural history of small colorectal adenomas showed no increase in size, no changes that would have necessitated treatment within a couple of years and that malignant transformation is rare. Using endoscopic follow up for a mean period of 43.1 months we assessed the development and progression of 408 protuberant adenomas that were under 10 mm in diameter. Of the 408 lesions, 22 (5.4%) underwent morphological changes. There were 12 lesions (2.9%) whose final tumor diameter had reached 10 mm or more. There were three lesions (0.7%) that developed and progressed into intramucosal cancer. We concluded from the literature and from our own results that small colorectal protuberant adenomas do not grow to advanced adenomas within 5 years.
authors.affiliation: Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan. hisabe@cis.fukuoka-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hisabe
authors.forename: Sumio
authors.initials: S
authors.lastname: Tsuda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsui
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
mesh_terms: D000236:Adenoma / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D009367:Neoplasm Staging