[Gastroprotective properties of mexidol and hypoxen].
Experimental damage in the stomach mucosa of test rats was modeled by acetylsalicylic acid (aspirin-induced ulcerogenesis). The number of ulcers and the total area of erosive injury in the mucous membrane were studied. Prophylactic treatment with mexidol and hypoxen in a daily dose of 50 mg/kg reduces the aspirin-induced damage of stomach mucosa. The gastroprotective properties of drugs are probably related to their antioxidant and antihypoxant effects.
Novikov
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VE
Kriukova
N O
NO
Novikov
A S
AS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants / Q000627:therapeutic use*; D001241:Aspirin; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D010647:Phenyl Ethers / Q000627:therapeutic use*; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D010647:Phenyl Ethers; D010847:Picolines; C085806:olifen; C070020:emoxypine succinate; D001241:Aspirin