Asymmetric synthesis of bis-tetrahydrofuran cores in annonaceous acetogenins.
The bis-THF cores of annonaceous acetogenins were synthesized using (3R,4R)-1,5-hexadiene-3,4-diol (1) as the sole source of carbon atoms. The methylene acetal function was applied as a new linker/tether to facilitate the ring-closing metathesis.
Chen
Chia-Hsiu
CH
Department of Chemistry, National Central University, 300 Jhong-Da Rd., Jhong-Li, Taoyuan, Taiwan.
Kuan
Ting-Chun
TC
Lu
Ke-Jhen
KJ
Hou
Duen-Ren
DR
D054378:Acetogenins / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
D054378:Acetogenins; D003432:Cross-Linking Reagents; D005663:Furans; C018674:tetrahydrofuran