Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes.
Anionic phthalocyanines inhibited efficiently telomerase activity even in the presence of excess double-stranded DNA (dsDNA) because of their selective binding to telomere G-quadruplex, although low selectivity of a typical cationic ligand, TMPyP4, to the G-quadruplex allowed telomerase reaction under conditions with dsDNA.
Yaku
Hidenobu
H
Advanced Technology Research Laboratories, Panasonic Corporation, 3-4 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan.
Murashima
Takashi
T
Miyoshi
Daisuke
D
Sugimoto
Naoki
N
D000838:Anions / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000378:metabolism*; D054856:G-Quadruplexes; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000838:Anions; D007211:Indoles; D054833:Isoindoles; D003300:Copper; D004247:DNA; D019098:Telomerase; C013647:phthalocyanine