Burkitt lymphoma: residual abdominal tumor volume after induction therapy correlates with outcome.
Staging investigations in the Malawi 2003 BL protocol included abdominal ultrasonography. This sometimes demonstrated tumor that was not palpable. Patients with no palpable tumor following induction with three courses of cyclophosphamide were considered to be in remission, although residual intraabdominal tumor was documented in some by chance. We repeated ultrasonography on day 29 on 22 new patients with non-palpable abdominal BL following induction. The relapse rate after 1 year correlated with the largest residual tumor volume, and was 17% for tumors 0-35 ml, and 75% for tumors > or = 35 ml in volume. Risk patients were thus identified.
Hesseling
Peter
P
Faculty of Health Sciences, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa. pbh@sun.ac.za
McCormick
Peter
P
Kouya
Francine
F
Soh
Felicite
F
Katayi
Tshimwanga
T
Noglik
Genny
G
Kidd
Martin
M
Kenyu
Ernest
E
Ngam
Ivo
I
Tata
George
G
D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000293:Adolescent; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D014463:Ultrasonography