Antioxidant approaches for the treatment of Alzheimer's disease.
Oxidative stress is an important factor, and one that acts in the earliest stages, of Alzheimer's disease (AD) pathogenesis. The reduction of oxidative stress has been tested as a therapy for AD. While the trial of vitamin E supplementation in moderately severe AD is the most promising so far, it also reveals the limitations of general antioxidant therapies that simply lower oxidative stress and, therefore, the complexity of the redox system. The multiple contributing factors that foster the clinical manifestations of AD should be considered when designing antioxidative stress therapy. In this article, we discuss the multiple pathogenic mechanisms of oxidative stress in AD and the potential targeting approaches.
Lee
Hyun Pil
HP
Case Western Reserve University, OH, USA.
Zhu
Xiongwei
X
Casadesus
Gemma
G
Castellani
Rudy J
RJ
Nunomura
Akihiko
A
Smith
Mark A
MA
Lee
Hyoung-gon
HG
Perry
George
G
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*
D000975:Antioxidants