title: Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis.
abstract: BACKGROUND
  The effectiveness of prophylactic central neck dissection (pCND) in the treatment of patients with papillary thyroid carcinoma (PTC) to prevent local recurrence is controversial. We performed a meta-analysis to assess the effect of pCND on local recurrence in PTC.
  
  
  METHODS
  Exhaustive search of online search engines identified five retrospective studies that compared the local recurrence rates of PTC in patients without clinically detectable nodal disease in patients undergoing thyroidectomy + pCND (group A) to those undergoing thyroidectomy alone (group B). A meta-analysis was performed by the fixed effects method. Recurrence was documented by imaging, thyroglobulin detection, or reoperation. Location of recurrence was identified in either the central or lateral neck compartment.
  
  
  RESULTS
  A total of 1264 patients were included, 396 in group A and 868 in group B. Follow-up ranged from 6 months to 27 years. The overall recurrence rate was 2.02% in group A versus 3.92% in group B (odds ratio [OR] = 1.05, 95% confidence interval [95% CI] 0.48-2.31). The recurrence rate in the central neck compartment in group A was 1.86% compared to 1.68% in group B (OR = 1.31, 95% CI 0.44-3.91). The recurrence rate in the lateral neck compartment in group A was 3.73% compared to 3.79% in group B (OR = 1.21, 95% CI 0.52-2.75). There was no statistically significant difference in the OR in the local recurrence between the two groups.
  
  
  CONCLUSIONS
  This meta-analysis indicates that pCND does not greatly reduce local recurrence in thyroid cancer. However, the available studies have substantial limitations and a prospective multicenter study to determine the indications for pCND is warranted.
authors.affiliation: Department of Surgery, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Tarek
authors.initials: T
authors.lastname: Zetoune
authors.forename: Xavier
authors.initials: X
authors.lastname: Keutgen
authors.forename: Daniel
authors.initials: D
authors.lastname: Buitrago
authors.forename: Hasan
authors.initials: H
authors.lastname: Aldailami
authors.forename: Huibo
authors.initials: H
authors.lastname: Shao
authors.forename: Madhu
authors.initials: M
authors.lastname: Mazumdar
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Fahey
authors.forename: Rasa
authors.initials: R
authors.lastname: Zarnegar
mesh_terms: D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome