title: Asymmetric synthesis of bis-tetrahydrofuran cores in annonaceous acetogenins.
abstract: The bis-THF cores of annonaceous acetogenins were synthesized using (3R,4R)-1,5-hexadiene-3,4-diol (1) as the sole source of carbon atoms. The methylene acetal function was applied as a new linker/tether to facilitate the ring-closing metathesis.
authors.affiliation: Department of Chemistry, National Central University, 300 Jhong-Da Rd., Jhong-Li, Taoyuan, Taiwan.
authors.forename: Chia-Hsiu
authors.initials: CH
authors.lastname: Chen
authors.forename: Ting-Chun
authors.initials: TC
authors.lastname: Kuan
authors.forename: Ke-Jhen
authors.initials: KJ
authors.lastname: Lu
authors.forename: Duen-Ren
authors.initials: DR
authors.lastname: Hou
mesh_terms: D054378:Acetogenins / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D054378:Acetogenins; D003432:Cross-Linking Reagents; D005663:Furans; C018674:tetrahydrofuran