Altered metabolism in cancer.
Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs. See research article: http://www.biomedcentral.com/1752-0509/4/58/
Locasale
Jason W
JW
Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA. jlocasal@bidmc.harvard.edu
Cantley
Lewis C
LC
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002952:Citric Acid Cycle / Q000235:genetics / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*
D000255:Adenosine Triphosphate; D005947:Glucose