title: Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives.
abstract: Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl₄-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.
authors.affiliation: Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India. drbahmed@rediffmail.com
authors.forename: Bahar
authors.initials: B
authors.lastname: Ahmed
authors.lastname: Habibullah
authors.forename: Shamshir
authors.initials: S
authors.lastname: Khan
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000737:chemistry; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury; D004146:Dioxanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000187:drug effects*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012838:Silymarin / Q000494:pharmacology
chemical_list: D004146:Dioxanes; D010069:Oxadiazoles; D012838:Silymarin; D002251:Carbon Tetrachloride; C025223:1,4-dioxane