Metabolic networks of longevity.
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.
Houtkooper
Riekelt H
RH
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Williams
Robert W
RW
Auwerx
Johan
J
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000601:Amino Acids, Essential / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008136:Longevity; D053858:Metabolic Networks and Pathways; D008715:Methionine / Q000378:metabolism*
D000601:Amino Acids, Essential; D008715:Methionine