title: Nuclear hormone receptors in parasitic helminths.
abstract: Nuclear receptors (NRs) belong to a large protein superfamily that are important transcriptional modulators in metazoans. Parasitic helminths include parasitic worms from the Lophotrochozoa (Platyhelminths) and Ecdysozoa (Nematoda). NRs in parasitic helminths diverged into two different evolutionary lineages. NRs in parasitic Platyhelminths have orthologues in Deuterostomes, in arthropods or both with a feature of extensive gene loss and gene duplication within different gene groups. NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss.
authors.affiliation: Department of Biochemistry, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA. w_wenjie@hotmail.com
authors.forename: Wenjie
authors.initials: W
authors.lastname: Wu
authors.forename: Philip T
authors.initials: PT
authors.lastname: LoVerde
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D020440:Gene Duplication; D008969:Molecular Sequence Data; D009348:Nematoda / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D010986:Platyhelminths / Q000235:genetics* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000378:metabolism; D017385:Sequence Homology
chemical_list: D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear