Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension.
OBJECTIVE
The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH).


METHODS
Ten T2D patients (age: 53.6±1.3 years; body mass index: 30.6±1.0kg/m(2); resting blood glucose: 157.8±40.2mgdL(-1)) and 10 non-diabetic (ND) volunteers (age: 47.5±1.0 years; body mass index: 28.3±0.9kg/m(2); resting blood glucose: 91.2±10.5mgdL(-1)) underwent two experimental sessions, consisting of 20min of rest plus 20min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3AC1-1 monitor) and PKA were measured during rest and every 15min for 135min of the postexercise recovery period (RP).


RESULTS
During the RP, the ND individuals presented with PEH at 30, 45 and 120min (P<0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15min postexercise in the ND (P<0.05), but not in the T2D patients.


CONCLUSIONS
T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH.
Motta
D F
DF
Catholic University of Brasília, UCB, Brazil; Federal University of Minas Gerais, UFMG, Brazil.
Lima
L C J
LC
Arsa
G
G
Russo
P S
PS
Sales
M M
MM
Moreira
S R
SR
Morais
P K
PK
Almeida
W S
WS
Araujo
R C
RC
Moraes
M R
MR
Pesquero
J L
JL
Simões
H G
HG
Campbell
C S G
CS
D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology*; D007610:Kallikreins / Q000097:blood*; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D007610:Kallikreins