Risk analysis of environmental chemicals on lung carcinogenesis.
Lung cancer is one of the most common cancers in the world, and the incidence of lung cancer is increasing. Risk analysis of environmental chemicals on lung carcinogenesis is particularly important. Detection of chemopreventive agents of lung carcinogenesis is also important to reduce our risk of lung cancer. For that purpose, it is necessary to establish reliable in vivo animal models of lung carcinogenesis. The A/J mouse is a mouse strain sensitive to lung carcinogens, and also develops spontaneous lung tumors without any chemical treatment. We have demonstrated that a treatment of 4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone (NNK), a tobacco specific nitrosamine, or 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (MeIQx), a heterocyclic amine, induced lung tumors in the female A/J mouse in 16 and 32 weeks. The lung tumors developed in the A/J mouse are histopathologically classified as adenocarcinomas, adenomas, and alveolar cell hyperplasias. Some of these types of lung cancer are similar to those of human lung cancer. We also investigated the chemopreventive effects of bovine LF (bLF) on different phases of NNK-induced lung tumorigenesis in A/J mice. The A/J mouse is very useful mouse strain as a reliable in vivo model, which can be used for risk analysis of lung carcinogenesis.
Imaida
Katsumi
K
Onco-Pathology, Department of Pathology and Host-Defenses, Faculty of Medicine, Kagawa University, Kagawa, Japan. imaida@med.kagawa-u.ac.jp
Yokohira
Masanao
M
Hashimoto
Nozomi
N
Kuno
Toshiya
T
D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D000236:Adenoma / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002417:Cattle; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007781:Lactoferrin / Q000494:pharmacology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008813:Mice, Inbred ICR; D009602:Nitrosamines / Q000633:toxicity*; D018570:Risk Assessment
D002273:Carcinogens; D009602:Nitrosamines; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D007781:Lactoferrin