title: Functional magnetic resonance imaging of a child with Alice in Wonderland syndrome during an episode of micropsia.
abstract: BACKGROUND
  Alice in Wonderland syndrome is a perceptual disorder involving brief, transient episodes of visual distortions (metamorphopsia) and can occur in conjunction with certain viral infections. We used functional magnetic resonance imaging to examine visual processing in a 12-year-old boy with viral-onset Alice in Wonderland syndrome during an episode of micropsia (reduction in the perceived size of a form).
  
  
  METHODS
  Functional magnetic resonance imaging was conducted in response to a passive viewing task (reversing checkerboard) and an active viewing task (line-length decisions in the context of the Ponzo illusion).
  
  
  RESULTS
  In both tasks, the child with Alice in Wonderland syndrome showed reduced activation in primary and extrastriate visual cortical regions but increased activation in parietal lobe cortical regions as compared with a matched control participant.
  
  
  CONCLUSIONS
  The active experience of micropsia in viral-onset Alice in Wonderland syndrome reflects aberrant activity in primary and extrastriate visual cortical regions as well as parietal cortices. The disparate patterns of activity in these regions are discussed in detail.
authors.affiliation: Joint Doctoral Program in Language and Communicative Disorders, San Diego State University/University of California-San Diego, 5500 Campanile Drive, San Diego, CA 92182-1518, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Brumm
authors.forename: Matthew
authors.initials: M
authors.lastname: Walenski
authors.forename: Frank
authors.initials: F
authors.lastname: Haist
authors.forename: Shira L
authors.initials: SL
authors.lastname: Robbins
authors.forename: David B
authors.initials: DB
authors.lastname: Granet
authors.forename: Tracy
authors.initials: T
authors.lastname: Love
mesh_terms: D000293:Adolescent; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010468:Perceptual Disorders / Q000175:diagnosis*; D013577:Syndrome; D014786:Vision Disorders / Q000175:diagnosis*; D014793:Visual Cortex / Q000473:pathology / Q000503:physiopathology