title: Mediodorsal thalamic stimulation is not protective against seizures induced by amygdaloid kindling in rats.
abstract: Deep brain stimulation (DBS) is now emerging as a new option for treating intractable epilepsy. Cumulative studies suggest that the mediodorsal thalamic nucleus (MD) is involved in limbic seizure activity. This study aims to investigate whether DBS of the MD can protect against seizures induced by amygdaloid kindling. We studied the effect of low-frequency stimulation (LFS, 1 Hz) or high-frequency stimulation (HFS, 100 Hz) in the MD on amygdaloid kindling seizures. During the kindling acquisition, DBS in the MD was daily administered immediately after the kindling stimulus or before the kindling stimulus (preemptive DBS). The effects of both post-treatment of DBS and preemptive DBS in the MD on the expression of amygdaloid kindling seizures were evaluated. We found the DBS or preemptive DBS in the MD, either LFS or HFS, did not significantly change the rate of amygdaloid kindling. Similarly, DBS or preemptive DBS in the MD did not significantly change any parameters representing the expression of amygdaloid kindling. Our study suggests that DBS in the MD may have no significant effect on limbic seizures.
authors.affiliation: Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Deng-Chang
authors.initials: DC
authors.lastname: Wu
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Fan
authors.forename: Mei-Zhen
authors.initials: MZ
authors.lastname: Zhu
authors.forename: Qiong-Yao
authors.initials: QY
authors.lastname: Hu
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Ding
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000679:Amygdala / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001703:Biophysics / Q000379:methods; D046690:Deep Brain Stimulation / Q000379:methods*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D020645:Mediodorsal Thalamic Nucleus / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000517:prevention & control*; D018709:Statistics, Nonparametric