Association between plasma adiponectin and high-density lipoprotein cholesterol in postmenopausal women.
OBJECTIVE
We investigated the association of plasma adiponectin and high-density lipoprotein cholesterol (HDL-C) in postmenopausal women.


METHODS
This was a cross-sectional study of 563 postmenopausal women with and 1029 without low HDL-C. Lipid profile, glucose, adiponectin, IL-1beta, IL-6, and TNF-alpha concentrations were measured.


RESULTS
Plasma adiponectin levels increased with age in elderly women. Plasma adiponectin levels were lower in subjects with low HDL-C (<50mg/dl), when compared with normal HDL-C subjects. In multiple stepwise linear regression analysis, adiponectin was a significant independent predictor of HDL-C concentration with body mass index, total cholesterol, and triglycerides. Values in the third and fourth quartile of adiponectin were associated with decreased odds ratio for low HDL-C (0.62; 95% CI, 0.44-0.87, 0.40; 95% CI, 0.27-0.58, respectively) when compared with values in the lowest quartile after multivariable adjustment.


CONCLUSIONS
Adiponectin was significantly associated with HDL-C concentration in postmenopausal women. These findings suggest that high adiponectin levels may have a protective effect on atherosclerosis with increasing HDL-C in postmenopausal women.
Park
Sung-Hee
SH
Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, South Korea. hypark65@nih.go.kr
Kim
Ji Young
JY
Lee
Jong Ho
JH
Park
Hyun-Young
HY
D052242:Adiponectin / Q000097:blood*; D000367:Age Factors; D050197:Atherosclerosis; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017698:Postmenopause / Q000097:blood*
D052242:Adiponectin; D001786:Blood Glucose; D008076:Cholesterol, HDL; D016207:Cytokines; D008055:Lipids