title: Chemotherapy and interferon-alpha treatment of Erdheim-Chester disease.
abstract: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis of an unknown origin. The prognosis of ECD is variable, and it mainly depends on the involved anatomic sites. The treatment modalities have not been standardized. Interferon-alpha (IFN) has been reported to be effective in the management of ECD. We report here on an uncommon case with ECD in a 17-year-old female who had multiple lesions in the whole body and she was treated with chemotherapy and IFN. She has remained disease-free for 2 years after the completion of treatment.
authors.affiliation: Department of Pediatrics, Gil Medical Center, Gachon Medical School, Gachon University of Medicine and Science, Incheon, Korea. isjeon@gilhospital.com
authors.forename: In-sang
authors.initials: IS
authors.lastname: Jeon
authors.forename: Sang Seon
authors.initials: SS
authors.lastname: Lee
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D031249:Erdheim-Chester Disease / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008727:Methotrexate / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D016898:Interferon-alpha; D014747:Vinblastine; D011241:Prednisone; D008727:Methotrexate