title: Hydrodynamic trap for single particles and cells.
abstract: Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 mum) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 mum of the trap center, corresponding to a trap stiffness of approximately 10(-5)-10(-4) pNnm.
authors.forename: Melikhan
authors.initials: M
authors.lastname: Tanyeri
authors.forename: Eric M
authors.initials: EM
authors.lastname: Johnson-Chavarria
authors.forename: Charles M
authors.initials: CM
authors.lastname: Schroeder