title: Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis.
abstract: Cerebrospinal fluid (CSF) urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) levels were measured in patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) by quantitative sandwich enzyme immunoassays. The CSF concentrations of uPA and MMP-9 were evaluated in 30 EOMA patients and 10 controls. The CSF uPA and MMP-9 levels of the EOMA patients were significantly higher than those of the controls (p<0.001). The positive detection values were 73% (22/30) and 86.7% (26/30) for uPA and MMP-9, respectively. The uPA detection was in correlation with headache duration (p=0.008) and stiff neck (p=0.048), while the MMP-9 was in correlation with CSF total protein (p=0.006), CSF leukocytosis (p=0.004) and CSF eosinophil numbers (p=0.02). CSF uPA and MMP-9 levels are potentially useful for the understanding of immunologic pathogenesis, for therapeutic targets, for the diagnosis of EOMA and for monitoring treatment efficacy.
authors.affiliation: Faculty of Medicine and Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Oranuch
authors.initials: O
authors.lastname: Sanpool
authors.forename: Pewpan M
authors.initials: PM
authors.lastname: Intapan
authors.forename: Tongjit
authors.initials: T
authors.lastname: Thanchomnang
authors.forename: Taweesak
authors.initials: T
authors.lastname: Santivarangkana
authors.forename: Kanigar
authors.initials: K
authors.lastname: Niwattayakul
authors.forename: Verajit
authors.initials: V
authors.lastname: Chotmongkol
authors.forename: Wanchai
authors.initials: W
authors.lastname: Maleewong
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000134:cerebrospinal fluid*; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000201:enzymology; D008875:Middle Aged; D017206:Strongylida Infections / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000201:enzymology; D014568:Urokinase-Type Plasminogen Activator / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: D014568:Urokinase-Type Plasminogen Activator; D020780:Matrix Metalloproteinase 9