title: Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome.
abstract: OBJECTIVE
  To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome.
  
  
  METHODS
  Randomized, controlled prospective trial.
  
  
  METHODS
  General Clinical Research Center (GCRC) at University of Oklahoma Health Sciences Center (OUHSC).
  
  
  METHODS
  Thirty-five subjects with obesity and metabolic syndrome were recruited in age- and gender-matched trios and were randomly assigned to the control (4 cups water/d), green tea (4 cups/d), or green tea extract (2 capsules and 4 cups water/d) group for 8 weeks. The tea and extract groups had similar dosing of epiogallocatechin-3-gallate (EGCG), the active compound in green tea.
  
  
  METHODS
  Anthropometrics, blood pressure, fasting glucose and lipids, nuclear magnetic resonance (NMR)-based lipid particle size, safety parameters, biomarkers of oxidative stress (oxidized low-density lipoprotein [LDL], myeloperoxidase [MPO], malondialdehyde and hydroxynonenals [MDA and HNE]), and free catechins were analyzed at screen and at 4 and 8 weeks of the study.
  
  
  RESULTS
  Pairwise comparisons showed green tea beverage and green tea extracts caused a significant decrease in body weight and body mass index (BMI) versus controls at 8 weeks (-2.5 +/- 0.7 kg, p < 0.01, and -1.9 +/- 0.6, p < 0.05, respectively). Green tea beverage showed a decreasing trend in LDL-cholesterol and LDL/high-density lipoprotein (HDL) versus controls (p < 0.1). Green tea beverage also significantly decreased MDA and HNE (-0.39 +/- 0.06 microM, p < 0.0001) versus controls. Plasma free catechins were detectable in both beverage and extract groups versus controls at screen and at 8 weeks, indicating compliance and bioavailability of green tea catechins.
  
  
  CONCLUSIONS
  Green tea beverage consumption (4 cups/d) or extract supplementation (2 capsules/d) for 8 weeks significantly decreased body weight and BMI. Green tea beverage further lowered lipid peroxidation versus age- and gender-matched controls, suggesting the role of green tea flavonoids in improving features of metabolic syndrome in obese patients.
authors.affiliation: Nutritional Sciences, Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. arpita.basu@okstate.edu
authors.forename: Arpita
authors.initials: A
authors.lastname: Basu
authors.forename: Karah
authors.initials: K
authors.lastname: Sanchez
authors.forename: Misti J
authors.initials: MJ
authors.lastname: Leyva
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Wu
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Betts
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Aston
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Lyons
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000097:blood; D001682:Biological Availability; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D028241:Camellia sinensis / Q000737:chemistry*; D016022:Case-Control Studies; D002392:Catechin / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D010349:Patient Compliance; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016037:Single-Blind Method
chemical_list: D000447:Aldehydes; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D008315:Malondialdehyde; D002392:Catechin; D002784:Cholesterol; C045651:epigallocatechin gallate