Developmental changes of radiological findings in Fukuyama-type congenital muscular dystrophy.
Fukuyama-type congenital muscular dystrophy (FCMD) is characterized by congenital muscular dystrophy and associated with neuropathological anomalies. However, the issue of whether the radiological findings of white-matter lesions represent delayed myelination, demyelination or other problems remains controversial. We present serial radiological findings, including MR spectroscopy (MRS), in a child with FCMD. These findings indicate a correlation between the imaging abnormalities and the choline/creatine ratio, suggesting the possible usefulness of MRS in addition to MRI for following FCMD patients.
Kato
Zenichiro
Z
Molecular and Cellular Biology, Harvard University, Cambridge, USA. zen-k@gifu-u.ac.jp
Morimoto
Masahiro
M
Orii
Kenji E
KE
Kato
Tomomi
T
Kondo
Naomi
N
D015415:Biomarkers / Q000032:analysis; D002794:Choline / Q000032:analysis*; D003401:Creatine / Q000032:analysis*; D003711:Demyelinating Diseases / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D058494:Walker-Warburg Syndrome / Q000150:complications* / Q000175:diagnosis*
D015415:Biomarkers; D003401:Creatine; D002794:Choline