Room-temperature synthesis of enantioenriched non-protected cyanohydrins using vanadium(salalen) catalyst.
Room-temperature synthesis of enantioenriched non-protected cyanohydrins using acetone cyanohydrin as the cyanide source was achieved by V(salalen) catalyst. Aliphatic aldehydes underwent the cyanation with 89-95% ee in the presence of only 0.2-0.4 mol% catalyst. Aromatic cyanohydrins were also obtained in high enantiomeric excesses under modified conditions.
Sakai
Yoshifumi
Y
Department of Chemistry, Faculty of Science, Graduate School, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Mitote
Junko
J
Matsumoto
Kazuhiro
K
Katsuki
Tsutomu
T