title: Advancing exposure characterization for chemical evaluation and risk assessment.
abstract: A new generation of scientific tools has emerged to rapidly measure signals from cells, tissues, and organisms following exposure to chemicals. High-visibility efforts to apply these tools for efficient toxicity testing raise important research questions in exposure science. As vast quantities of data from high-throughput screening (HTS) in vitro toxicity assays become available, this new toxicity information must be translated to assess potential risks to human health from environmental exposures. Exposure information is required to link information on potential toxicity of environmental contaminants to real-world health outcomes. In the immediate term, tools are required to characterize and classify thousands of environmental chemicals in a rapid and efficient manner to prioritize testing and assess potential for risk to human health. Rapid risk assessment requires prioritization based on both hazard and exposure dimensions of the problem. To address these immediate needs within the context of longer term objectives for chemical evaluation and risk management, a translation framework is presented for incorporating toxicity and exposure information to inform public health decisions at both the individual and population levels. Examples of required exposure science contributions are presented with a focus on early advances in tools for modeling important links across the source-to-outcome paradigm. ExpoCast, a new U.S. Environmental Protection Agency (EPA) program aimed at developing novel approaches and metrics to screen and evaluate chemicals based on the potential for biologically relevant human exposures is introduced. The goal of ExpoCast is to advance characterization of exposure required to translate findings in computational toxicology to information that can be directly used to support exposure and risk assessment for decision making and improved public health.
authors.affiliation: National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. hubal.elaine@epa.gov
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Cohen Hubal
authors.forename: Ann
authors.initials: A
authors.lastname: Richard
authors.forename: Lesa
authors.initials: L
authors.lastname: Aylward
authors.forename: Steve
authors.initials: S
authors.lastname: Edwards
authors.forename: Jane
authors.initials: J
authors.lastname: Gallagher
authors.forename: Michael-Rock
authors.initials: MR
authors.lastname: Goldsmith
authors.forename: Sastry
authors.initials: S
authors.lastname: Isukapalli
authors.forename: Rogelio
authors.initials: R
authors.lastname: Tornero-Velez
authors.forename: Eric
authors.initials: E
authors.lastname: Weber
authors.forename: Robert
authors.initials: R
authors.lastname: Kavlock
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D003657:Decision Making; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity*; D015386:Hazardous Substances / Q000009:adverse effects / Q000032:analysis; D057166:High-Throughput Screening Assays; D006801:Humans; D018570:Risk Assessment; D012308:Risk Management / Q000379:methods; D018675:Toxicity Tests / Q000379:methods; D014116:Toxicology / Q000379:methods*; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances