Decreased ventral striatal activity with impulse control disorders in Parkinson's disease.
A range of impulse control disorders (ICDs) are reported to occur in Parkinson's disease (PD). However, alterations in brain activity at rest and during risk taking occurring with ICDs in PD are not well understood. We used both arterial spin labeling perfusion functional magnetic resonance imaging (fMRI) to directly quantify resting cerebral blood flow (CBF) and blood oxygenation level dependent (BOLD) fMRI to measure neural responses to risk taking during performance on the Balloon Analogue Risk Task (BART). Eighteen PD patients, either with a diagnosis of one or more ICDs (N = 9) or no lifetime ICD history (N = 9), participated. BOLD fMRI data demonstrated that PD patients without an ICD activate the mesocorticolimbic pathway during risk taking. Compared with non-ICD patients, ICD patients demonstrated significantly diminished BOLD activity in the right ventral striatum during risk taking and significantly reduced resting CBF in the right ventral striatum. ICDs in PD are associated with reduced right ventral striatal activity at rest and diminished striatal activation during risk taking, suggesting that a common neural mechanism may underlie ICDs in individuals with PD and those without PD. Thus, treatments for ICDs in non-PD patients warrant consideration in PD patients with ICDs.
Rao
Hengyi
H
Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mamikonyan
Eugenia
E
Detre
John A
JA
Siderowf
Andrew D
AD
Stern
Matthew B
MB
Potenza
Marc N
MN
Weintraub
Daniel
D
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000098:blood supply / Q000503:physiopathology*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010300:Parkinson Disease / Q000150:complications*; D012146:Rest / Q000502:physiology; D013647:Task Performance and Analysis
D010100:Oxygen