Translating stem cell research: challenges at the research frontier.
This paper will address the translation of basic stem cell research into clinical research. While "stem cell" trials are sometimes used to describe established practices of bone marrow transplantation or transplantation of primary cells derived from bone marrow, for the purposes of this paper, I am primarily focusing on stem cell trials which are far less established, including use of hESC derived stem cells. The central ethical challenges in stem cell clinical trials arise in frontier research, not in standard, well-established areas of research.
Magnus
David
D
Stanford University, USA.
D000818:Animals; D002986:Clinical Trials as Topic / Q000145:classification / Q000941:ethics* / Q000331:legislation & jurisprudence; D004059:Diffusion of Innovation; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells; D018014:Gene Transfer Techniques / Q000941:ethics; D033161:Government Regulation; D017408:Guidelines as Topic; D006801:Humans; D007258:Informed Consent / Q000941:ethics / Q000331:legislation & jurisprudence; D012107:Research Design; D035845:Research Embryo Creation / Q000941:ethics* / Q000331:legislation & jurisprudence; D012449:Safety; D012935:Social Justice / Q000941:ethics; D033581:Stem Cell Transplantation / Q000941:ethics* / Q000331:legislation & jurisprudence; D055990:Therapeutic Misconception / Q000941:ethics; D057170:Translational Research, Biomedical / Q000941:ethics* / Q000458:organization & administration; D014481:United States; D014486:United States Food and Drug Administration