title: Arabinosylated glycopeptide hormones: new insights into CLAVATA3 structure.
abstract: Secreted peptides are now recognized as important members of hormones that coordinate and specify cellular functions in plants. Recent accumulating evidence shows that secreted peptide hormones are often post-translationally modified, and such modification is critical for their function. In this review, we highlight hydroxyproline arabinosylation, which has been found in several peptide hormones including CLAVATA3 (CLV3), a key peptide controlling stem cell renewal and differentiation in Arabidopsis shoot apical meristem. Arabinosylation of CLV3 is important for its biological activity and for high-affinity binding to its receptor, CLV1. We discuss the physiological functions of known glycopeptide hormones, the structural information on sugar chains, and possible mechanisms of glycosylation.
authors.affiliation: Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Shinohara
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Matsubayashi
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D001089:Arabinose / Q000378:metabolism; D006020:Glycopeptides / Q000378:metabolism; D006031:Glycosylation; D036361:Peptide Hormones / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
chemical_list: C118167:AT2G27250 protein, Arabidopsis; D029681:Arabidopsis Proteins; D006020:Glycopeptides; D036361:Peptide Hormones; D010937:Plant Growth Regulators; D001089:Arabinose