Postexposure treatment of Marburg virus infection.
Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.
Geisbert
Thomas W
TW
National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts 02118, USA. geisbert@bu.edu
Hensley
Lisa E
LE
Geisbert
Joan B
JB
Leung
Anders
A
Johnson
Joshua C
JC
Grolla
Allen
A
Feldmann
Heinz
H
D000818:Animals; D008253:Macaca mulatta; D008379:Marburg Virus Disease / Q000517:prevention & control*; D029024:Marburgvirus / Q000276:immunology*; D008992:Monkey Diseases / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics; D014765:Viral Vaccines / Q000276:immunology*
D014614:Vaccines, Synthetic; D014765:Viral Vaccines