Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity.
Chemical investigation of the tubers of Corydalis ternata resulted in the isolation and characterization of four new benzylisoquinoline alkaloids, epi-coryximine (1) and coryternatines A-C (2-4), along with 10 known alkaloids (5-14). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. In addition, the cytotoxicities of the alkaloids (1-14) were evaluated by determining their inhibitory effects on several human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) using the SRB assay. Compound 8 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC(50)=8.34, 5.14, 7.87, and 2.86 microM, respectively). The four new compounds (1-4) exhibited selective cytotoxicity against the HCT-15 cell line.
Kim
Ki Hyun
KH
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Jangan-ku, Suwon 440-746, Republic of Korea.
Lee
Il Kyun
IK
Piao
Cheng Jie
CJ
Choi
Sang Un
SU
Lee
Jei Hyun
JH
Kim
Yeong Shik
YS
Lee
Kang Ro
KR
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D044182:Benzylisoquinolines / Q000737:chemistry*; D045744:Cell Line, Tumor; D031311:Corydalis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D035281:Plant Tubers / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines