title: Synthesis and cytotoxic activities of group 3 metal complexes having monoanionic tridentate ligands.
abstract: Complexes of scandium, yttrium, samarium and neodymium bearing monoanionic tridentate ancillary ligands have been synthesized and characterized. The cytotoxic activities of novel compounds, as well as that of similar compounds previously reported have been evaluated on rat glioma (C6), murine fibrosarcoma (WHEI-164) and human embryonic kidney (HEK-293) cell lines. Scandium complex with quinolinephenoxyamine (NNHO) ligand showed very interesting activity against C6 cell line.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte don Melillo, 84084 Fisciano (SA), Italy. saturnino@unisa.it
authors.forename: Carmela
authors.initials: C
authors.lastname: Saturnino
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Napoli
authors.forename: Gino
authors.initials: G
authors.lastname: Paolucci
authors.forename: Marco
authors.initials: M
authors.lastname: Bortoluzzi
authors.forename: Ada
authors.initials: A
authors.lastname: Popolo
authors.forename: Aldo
authors.initials: A
authors.lastname: Pinto
authors.forename: Pasquale
authors.initials: P
authors.lastname: Longo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008674:Metals, Rare Earth / Q000737:chemistry*; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry; D051381:Rats; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; D011804:Quinolines