Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation.
HLA antibody-incompatible transplantation has a higher risk of rejection when compared to standard renal transplantation. Soluble CD30 (sCD30) has been shown in many, but not all, studies to be a biomarker for risk of rejection in standard renal transplant recipients. We sought to define the value of sCD30 and soluble CD27 (sCD27) in patients receiving HLA antibody-incompatible transplants. Serum taken at different time points from 32 HLA antibody-incompatible transplant recipients was retrospectively assessed for sCD30 and sCD27 levels by enzyme-linked immunosorbent assay (ELISA). This was compared to episodes of acute rejection, post-transplant donor-specific antibody (DSA) levels and 12 month serum creatinine levels. No association was found between sCD27 and sCD30 levels and risk of acute rejection or DSA levels. Higher sCD30 levels at 4-6 weeks post-transplantation were associated with a higher serum creatinine at 12 months. Conclusion patients undergoing HLA antibody-incompatible transplantation are at a high risk of rejection but neither sCD30 (unlike in standard transplantation) nor sCD27 was found to be a risk factor. High sCD30 levels measured at 4-6 weeks post-transplantation was associated with poorer graft function at one year.
Hamer
Rizwan
R
Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK. rizwanhamer@yahoo.co.uk
Roche
Laura
L
Smillie
David
D
Harmer
Andrea
A
Mitchell
Daniel
D
Molostvov
Guerman
G
Lam
For T
FT
Kashi
Habib
H
Tan
Lam Chin
LC
Imray
Chris
C
Fletcher
Simon
S
Briggs
David
D
Lowe
David
D
Zehnder
Daniel
D
Higgins
Rob
R
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000276:immunology / Q000378:metabolism*; D017730:Ki-1 Antigen / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000097:blood
D015415:Biomarkers; D006680:HLA Antigens; D007518:Isoantibodies; D017730:Ki-1 Antigen; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D003404:Creatinine