title: Surgery for renal cell carcinoma metastases.
abstract: OBJECTIVE
  Despite the emergence of molecular targeted systemic therapy for metastatic renal cell carcinoma, cure is uncommonly achieved in the absence of surgical resection. We review the current role of metastasectomy and factors associated with outcome.
  
  
  RESULTS
  Recent publication of large observational studies has better defined the expected prognosis of patients with metastatic renal cell carcinoma with or without metastasectomy. These data have highlighted prognostic factors for survival in patients treated with metastasectomy.
  
  
  CONCLUSIONS
  Patients with metastatic renal cell carcinoma should be considered for multimodal therapy, including surgery. A proportion of patients will achieve long-term survival with aggressive surgical resection.
authors.affiliation: Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Rodney H
authors.initials: RH
authors.lastname: Breau
authors.forename: Michael L
authors.initials: ML
authors.lastname: Blute
mesh_terms: D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D020360:Neoadjuvant Therapy; D009392:Nephrectomy; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D016896:Treatment Outcome