title: Effect on seroprevalence of anti-poliovirus antibodies and on vaccination coverage of the implementation of a DTwP-IPV-Hib vaccination programme in a South American city.
abstract: Vaccination coverage and seroprevalence of poliovirus antibodies were assessed in Argentinean children (aged 8-12 and 19-21 months) living in Cordoba City pre-/post-implementation of a DTwP-IPV-Hib vaccination programme, and compared to those of controls from neighbouring populations receiving a full oral poliovirus vaccine schedule. Vaccination coverage was higher in control areas pre-intervention; this increased post-intervention in Cordoba (>90%) but not in control areas. Poliovirus types 1 and 2 seroprotection rates were >97% in all groups pre-/post-intervention. Type 3 seroprotection rates were generally lower, but increased post-intervention in Cordoba becoming significantly higher than control rates. Anti-type 1 and 3 antibody titres increased twofold and sevenfold, respectively, post-intervention, whereas anti-type 2 antibody titres decreased ~40% in the 8-12 months group. All titres increased in the 19-21 months post-intervention group. The introduction of a three-dose primary DTwP-IPV-Hib schedule maintained protection against poliovirus types 1 and 2, and increased protection against type 3, while vaccine coverage in the study area increased.
authors.affiliation: Instituto de Virología Dr. J. M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
authors.forename: S V
authors.initials: SV
authors.lastname: Nates
authors.forename: M
authors.initials: M
authors.lastname: Frias
authors.forename: S
authors.initials: S
authors.lastname: Belfiore
authors.forename: M B
authors.initials: MB
authors.lastname: Isa
authors.forename: L C
authors.initials: LC
authors.lastname: Martinez
authors.forename: R
authors.initials: R
authors.lastname: Chuit
authors.forename: J
authors.initials: J
authors.lastname: Armoni
authors.forename: C
authors.initials: C
authors.lastname: Luxemburger
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D001118:Argentina / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology; D006801:Humans; D017589:Immunization Programs / Q000706:statistics & numerical data; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology* / Q000627:therapeutic use; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D014505:Urban Population; D017778:Vaccines, Combined / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined