Association of the fatty acid-binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a meta-analysis in 13451 subjects.
BACKGROUND
The results from the published studies on the association of fatty acid-binding protein 2 (FABP2) Ala54Thr polymorphism with insulin resistance and blood glucose are conflicting. In this meta-analysis, we investigated the association of the FABP2 Ala54Thr polymorphism with insulin resistance and blood glucose.


METHODS
We collected data on fasting blood glucose and fasting insulin, 2-h blood glucose (2-h BG) and 2-h insulin (2-h insulin), and homeostasis model assessment insulin resistance index. A dominant model was used for this meta-analysis.


RESULTS
Thirty-one studies with 13 451 subjects were included in this meta-analysis. The carriers of Thr54 allele have significantly higher homeostasis model assessment insulin resistance index and marginally higher fasting insulin than the non-carriers: standardized mean difference (SMD) = 0.07, 95% confidence interval (CI, 0.02, 0.12), p = 0.007, p(heterogeneity) = 0.19 and SMD = 0.08, 95% CI (-0.01, 0.17), p = 0.07, p(heterogeneity) < 0.00001, respectively. A borderline significant association between the FABP2 Ala54Thr polymorphism and an increased 2-h BG was also detected under the dominant model: SMD = 0.10, 95% CI (0.00, 0.20), p = 0.05, p(heterogeneity) = 0.09. In addition, a borderline association between this polymorphism and an increased fasting blood glucose in populations of other ethnic origins was detected under the dominant model: SMD = 0.11, 95% CI (-0.00, 0.23), p = 0.06, p(heterogeneity) = 0.03.


CONCLUSIONS
Our meta-analysis suggests that the Thr54 allele of the FABP2 Ala54Thr is weakly associated with a higher degree of insulin resistance, higher level of fasting insulin and higher level of 2-h BG. Our meta-analysis also suggests a weak association between this polymorphism and an increased fasting blood glucose in populations of other ethnic origins under the dominant model.
Zhao
Tongfeng
T
Department of Geriatrics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhao
Jiangpei
J
Yang
Wanxi
W
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D011110:Polymorphism, Genetic
D001786:Blood Glucose; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D007328:Insulin