title: Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.
abstract: OBJECTIVE
  To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS).
  
  
  METHODS
  Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1Glu69 in additive, dominant, and recessive inheritance models.
  
  
  RESULTS
  IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized.
  
  
  CONCLUSIONS
  These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS.
authors.affiliation: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. eim4@cdc.gov
authors.forename: Erin C
authors.initials: EC
authors.lastname: McCanlies
authors.forename: Berran
authors.initials: B
authors.lastname: Yucesoy
authors.forename: Anna
authors.initials: A
authors.lastname: Mnatsakanova
authors.forename: James E
authors.initials: JE
authors.lastname: Slaven
authors.forename: Michael
authors.initials: M
authors.lastname: Andrew
authors.forename: Bonnie L
authors.initials: BL
authors.lastname: Frye
authors.forename: Christine R
authors.initials: CR
authors.lastname: Schuler
authors.forename: Kathleen
authors.initials: K
authors.lastname: Kreiss
authors.forename: Ainsley
authors.initials: A
authors.lastname: Weston
mesh_terms: D001607:Berylliosis / Q000235:genetics* / Q000276:immunology; D001608:Beryllium / Q000276:immunology*; D002908:Chronic Disease; D015331:Cohort Studies; D056726:Genetic Association Studies; D006682:HLA-DP Antigens / Q000235:genetics / Q000276:immunology; D059868:HLA-DP beta-Chains; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics* / Q000276:immunology; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D016906:Interleukin-9 / Q000235:genetics / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D053651:Receptors, Interleukin-9 / Q000235:genetics / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000235:genetics* / Q000276:immunology
chemical_list: D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; C508607:IL9 protein, human; D007375:Interleukin-1; D007376:Interleukin-2; D016906:Interleukin-9; D053651:Receptors, Interleukin-9; D001608:Beryllium