Quality control of phenotypic forms data in the Type 1 Diabetes Genetics Consortium.
BACKGROUND
When collecting phenotypic data in clinics across the globe, the Type 1 Diabetes Genetics Consortium (T1DGC) used several techniques that ensured consistency, completeness, and accuracy of the data.


OBJECTIVE
The aim of this article is to describe the procedures used for collection, entry, processing, and management of the phenotypic data in this international study.


METHODS
The T1DGC ensured the collection of high quality data using the following procedures throughout the entire study period. The T1DGC used centralized and localized training, required a pilot study, certified all data entry personnel, created standardized data collection forms, reviewed a sample of form sets quarterly throughout the duration of the study, and used a data entry system that provided immediate feedback to those entering the data.


RESULTS
Due to the intensive procedures in developing the forms, the study was able to uphold consistency among all clinics and minimal changes were required after implementation of the forms. The train-the-trainer model was efficient and only a small number of clinics had to repeat a pilot study. The study was able to maintain a low percentage of missing data (<0.001%) and low duplicate data entry error rate (0.10%).


CONCLUSIONS
It is critical to provide immediate follow-up in order to reinforce training and ensure the quality of the data collected and entered.
Perdue
Letitia H
LH
Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. lperdue@wfubmc.edu
Albret
Lotte
L
Aldrich
Alan
A
Loth
Amanda
A
Sides
Elizabeth G
EG
Dove
Angela
A
Wägner
Ana M
AM
Waterman
Rebecca
R
Pierce
June J
JJ
Akolkar
Beena
B
Steffes
Michael W
MW
Hilner
Joan E
JE
D035843:Biomedical Research / Q000458:organization & administration; D003625:Data Collection / Q000941:ethics / Q000379:methods*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D014943:Global Health; D006801:Humans; D007258:Informed Consent; D038622:Internationality; D010641:Phenotype; D010865:Pilot Projects; D011786:Quality Control