Clinical features and independent prognostic factors for acute bacterial meningitis in adults.
BACKGROUND
Clinical recognition of acute bacterial meningitis (ABM) and its early prognostication would guide the degree of intensive treatment required. We aimed to study the clinical features and factors associated with death in patients with community acquired ABM.


METHODS
Adult patients with clinically suspected community acquired ABM (CAABM) were studied between July 2004 to September 2008 (retrospective and prospective). Detailed history, clinical examination, cerebrospinal fluid (CSF) analysis, and laboratory investigations were performed and noted. The complications with which the patient presented or developed during hospital course were also noted. The outcome noted was at the time of discharge.


RESULTS
In multivariate logistic regression, independent factors associated with death were rural area of residence, presentation after >24 h, total leukocyte count (TLC) of <15000, CSF neutrophils <75%, low GCS at the time of admission, and a high creatinine level.


CONCLUSIONS
In the present study, most of the factors predicting death were identified at the time of admission. Identification of these factors could help prioritizing patients needing intensive care facilities, especially in resource poor setting.
Vibha
Deepti
D
Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India.
Bhatia
Rohit
R
Prasad
Kameshwar
K
Srivastava
M V Padma
MV
Tripathi
Manjari
M
Singh
Mamta Bhushan
MB
D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality; D016017:Odds Ratio; D011379:Prognosis; D013902:Radiography, Thoracic; D012424:Rural Population; D012640:Seizures / Q000209:etiology / Q000401:mortality; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome