title: Biomarkers of Alzheimer's disease in body fluids.
abstract: Various innovative diagnostic methods for Alzheimer's disease (AD) have been developed in view of the increasing prevalence and consequences of later-life dementia. Biomarkers in cerebrospinal fluid (CSF) and blood for AD are primarily based on the detection of components derived from amyloid plaques and neurofibrillary tangles (NFTs). Published reports on CSF and blood biomarkers in AD indicate that although biomarkers in body fluids may be utilized in the clinical diagnosis of AD, there are no specific markers that permit accurate and reliable diagnosis of early-stage AD or the monitoring of disease progression.
authors.affiliation: College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China.
authors.forename: YanPeng
authors.initials: Y
authors.lastname: Zheng
authors.forename: JinSheng
authors.initials: J
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Hong
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D003704:Dementia / Q000134:cerebrospinal fluid; D018450:Disease Progression; D006801:Humans; D016874:Neurofibrillary Tangles
chemical_list: D015415:Biomarkers