Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives.
A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p <0.05) anti-inflammatory activity.
Mokale
Santosh N
SN
Dr. Rafiq Zakaria Campus, Y.B. Chavan College of Pharmacy, Aurangabad 431 001 (M.S.), India. santoshmokale@rediffmail.com
Shinde
Sandeep S
SS
Elgire
Rupali D
RD
Sangshetti
Jaiprakash N
JN
Shinde
Devanand B
DB
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D051381:Rats; D013890:Thiourea / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D004008:Diclofenac; D013890:Thiourea; C029658:propionic acid