title: Liver dysfunction related to hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive therapy.
abstract: BACKGROUND
  There is no information about the frequency of liver dysfunction in patients with inflammatory bowel disease (IBD) treated with immunosuppressants and infected with hepatitis B (HBV) and/or C virus (HCV).
  
  
  OBJECTIVE
  To assess the influence of immunosuppressants on the course of HBV and HCV infection in IBD.
  
  
  METHODS
  Patients with IBD with HBV and/or HCV infection from 19 Spanish hospitals were included. Clinical records were reviewed for the type of immunosuppressant used, treatment duration, liver function tests and viral markers before, during and after each immunosuppressant. Logistic and Cox regression analysis were used to identify predictors of outcome.
  
  
  RESULTS
  162 patients were included; 104 had HBV markers (25 HBsAg positive) and 74 had HCV markers (51 HCV-RNA positive), and 16 patients had markers of both infections. Liver dysfunction was observed in 9 of 25 HBsAg positive patients (36%), 6 of whom developed hepatic failure. Liver dysfunction in HCV was observed in 8 of 51 HCV-RNA positive patients (15.7%), and only one developed hepatic failure. The frequency and severity of liver dysfunction was significantly higher in HBV-infected patients than in HCV-infected patients (p=0.045 and p=0.049, respectively). Treatment with ≥2 immunosuppressants was an independent predictor of HBV reactivation (OR 8.75; 95% CI 1.16 to 65.66). The majority of patients without reactivation received only one immunosuppressant for a short period and/or prophylactic antiviral treatment. No definite HBV reactivations were found in anti-HBc positive patients lacking HBsAg.
  
  
  CONCLUSIONS
  Liver dysfunction in patients with IBD treated with immunosuppressants is more frequent and severe in those with HBV than in HCV carriers and is associated with combined immunosuppression.
authors.affiliation: Department of Gastroenterology, Hospital Mútua de Terrassa, Universitat de Barcelona, Plaça Dr Robert no. 5, Terrassa, Barcelona, Catalonia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Loras
authors.forename: J P
authors.initials: JP
authors.lastname: Gisbert
authors.forename: M
authors.initials: M
authors.lastname: Mínguez
authors.forename: O
authors.initials: O
authors.lastname: Merino
authors.forename: L
authors.initials: L
authors.lastname: Bujanda
authors.forename: C
authors.initials: C
authors.lastname: Saro
authors.forename: E
authors.initials: E
authors.lastname: Domenech
authors.forename: J
authors.initials: J
authors.lastname: Barrio
authors.forename: M
authors.initials: M
authors.lastname: Andreu
authors.forename: I
authors.initials: I
authors.lastname: Ordás
authors.forename: L
authors.initials: L
authors.lastname: Vida
authors.forename: G
authors.initials: G
authors.lastname: Bastida
authors.forename: F
authors.initials: F
authors.lastname: González-Huix
authors.forename: M
authors.initials: M
authors.lastname: Piqueras
authors.forename: D
authors.initials: D
authors.lastname: Ginard
authors.forename: X
authors.initials: X
authors.lastname: Calvet
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Abad
authors.forename: M
authors.initials: M
authors.lastname: Torres
authors.forename: J
authors.initials: J
authors.lastname: Panés
authors.forename: M
authors.initials: M
authors.lastname: Chaparro
authors.forename: I
authors.initials: I
authors.lastname: Pascual
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez-Carballeira
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Bañares
authors.forename: J M
authors.initials: JM
authors.lastname: Viver
authors.forename: M
authors.initials: M
authors.lastname: Esteve
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000209:etiology; D005260:Female; D016174:Hepacivirus / Q000502:physiology; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D013030:Spain / Q000453:epidemiology; D014775:Virus Activation / Q000187:drug effects
chemical_list: D007166:Immunosuppressive Agents