Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study.
Thirty Parkinson's disease (PD) patients were divided into three equal groups according to their disease duration while 10 normal healthy volunteers matched for age and sex served as a control group. Striatal and extrastriatal serotonergic function was studied with (11)C-DASB PET, a marker of serotonin transporter availability. (11)C-DASB binding was correlated with disease disability and exposure to dopaminergic therapy. We found significant (11)C-DASB binding reductions in striatal, brainstem, and cortical regions in PD but no correlations were evident between (11)C-DASB binding and UPDRS scores, Hoehn &Yahr staging, disease duration and level of exposure to dopaminergic therapy. Our results suggest that progressive non-linear serotonergic dysfunction occurs in PD but it does not determine levels of disability. Additionally, chronic exposure to dopaminergic therapy does not appear to influence SERT binding.
Politis
Marios
M
MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK. marios.politis@imperial.ac.uk
Wu
Kit
K
Loane
Clare
C
Kiferle
Lorenzo
L
Molloy
Sophie
S
Brooks
David J
DJ
Piccini
Paola
P
D000328:Adult; D000368:Aged; D001596:Benzylamines; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012701:Serotonin / Q000172:deficiency* / Q000502:physiology*; D012720:Severity of Illness Index
D001596:Benzylamines; D002250:Carbon Radioisotopes; C420885:N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine; D012701:Serotonin