title: The effect of a single intramammary infusion of a biological response modifier in cows at drying off.
abstract: Biological response modifiers (BRM) are compounds that interact with the immune system to regulate specific aspects of host response. The objective of this study was to describe clinical and morphological changes during involution of bovine mammary gland following a single-dose infusion of a BRM containing lipopolysaccharide and cellular fractions of Escherichia coli incorporated into liposomes. A massive leukocyte response and increased subepithelial stroma infiltration of mononuclear cells, eosinophils and mast cells was observed in BRM-treated quarters compared with untreated controls; however, morphologic parameters assessed at 11 days post infusion were indicative of only slightly accelerated involution compared with untreated controls. In addition, BRM infusion at the end of lactation did not interfere with mammary epithelial cell proliferation and caused only mild systemic effects.
authors.affiliation: Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Rvdo. Padre Kreder 2805, (3080), Esperanza, Santa Fe, Argentina. bdallard@fcv.unl.edu.ar
authors.forename: Bibiana Elisabet
authors.initials: BE
authors.lastname: Dallard
authors.forename: H H
authors.initials: HH
authors.lastname: Ortega
authors.forename: I A
authors.initials: IA
authors.lastname: Iguzquiza
authors.forename: N R
authors.initials: NR
authors.lastname: Salvetti
authors.forename: O A
authors.initials: OA
authors.lastname: Quaino
authors.forename: L F
authors.initials: LF
authors.lastname: Calvinho
mesh_terms: D000818:Animals; D002417:Cattle; D002462:Cell Membrane; D049109:Cell Proliferation; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D007774:Lactation / Q000502:physiology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008081:Liposomes / Q000032:analysis*; D008321:Mammary Glands, Animal / Q000187:drug effects*; D008892:Milk / Q000166:cytology; D012270:Ribosomes
chemical_list: D007155:Immunologic Factors; D008070:Lipopolysaccharides; D008081:Liposomes