[Amiodarone-induced liver dysfunctions].
Amiodarone, a diiodinated benzofuran derivative, is widely used for treating ventricular and supraventricular tachyarrhythmias. Amiodarone is highly lipophilic and accumulation in the liver can be 500 times higher than serum amiodarone levels. Due to a long half-life and the lipophilic properties, the stored drug is capable of damaging the liver long after the drug has been stopped. Serious liver damage can lead to acute liver failure, cirrhosis and the need for liver transplantation. In this article we describe amiodarone-induced liver dysfunction and the diagnostic and therapeutic challenges in patients on amiodarone.
Gassanov
N
N
Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln. Natig.Gassanov@uk-koeln.de
Caglayan
E
E
Erdmann
E
E
Er
F
F
D000410:Alanine Transaminase / Q000097:blood; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D001281:Atrial Fibrillation / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged
D000889:Anti-Arrhythmia Agents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000638:Amiodarone