title: Generation and preservation of the slow underlying membrane potential oscillation in model bursting neurons.
abstract: The underlying membrane potential oscillation of both forced and endogenous slow-wave bursting cells affects the number of spikes per burst, which in turn affects outputs downstream. We use a biophysical model of a class of slow-wave bursting cells with six active currents to investigate and generalize correlations among maximal current conductances that might generate and preserve its underlying oscillation. We propose three phases for the underlying oscillation for this class of cells: generation, maintenance, and termination and suggest that different current modules coregulate to preserve the characteristics of each phase. Coregulation of I(Burst) and I(A) currents within distinct boundaries maintains the dynamics during the generation phase. Similarly, coregulation of I(CaT) and I(Kd) maintains the peak and duration of the underlying oscillation, whereas the calcium-activated I(KCa) ensures appropriate termination of the oscillation and adjusts the duration independent of peak.
authors.affiliation: University of Missouri, Department of Electrical and Computer Engineering, 349 EBW, Columbia, MO 65211, USA.
authors.forename: Clarence C
authors.initials: CC
authors.lastname: Franklin
authors.forename: John M
authors.initials: JM
authors.lastname: Ball
authors.forename: David J
authors.initials: DJ
authors.lastname: Schulz
authors.forename: Satish S
authors.initials: SS
authors.lastname: Nair
mesh_terms: D000818:Animals; D001048:Aplysia; D003386:Brachyura; D020013:Calcium Signaling / Q000502:physiology*; D003445:Crustacea; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013997:Time Factors