[CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Bone quality in chronic kidney disease : enzymatic and non-enzymatic glycation or oxidation induced cross-links in bone].
Collagen cross-link formation in bone plays an important role in bone strength and the proper biological function of bone (Saito M, Osteoporos Int, [REVIEW] 2010). Plasma homocysteine (Hcys) level and oxidative stress are increased in patient with chronic kidney disease (CKD) at stage 3. Such moderately increased plasma content of Hcys and oxidative stress are well known to be an independent fracture risk. In a case-controlled study, a significant reduction in the actual amount of enzymatic cross-links and a marked increased in advanced glycation end products cross-link, pentosidine, in bone from patients with post-menopausal osteoporotic hip fracture showing hyperhomocysteinemia (Saito M, Calcif Tissue Int 2006). Additionally, hyperhomocysteinemia induced animal model also showed the same collagen cross-links abnormalities as patients with hyperhomocysteinemia (Saito M, Osteoporos Int, 2010). In this review, we summarized the recent literature.
Saito
Mitsuru
M
Department of Orthopaedic Surgery, Jikei University School of Medicine.
Marumo
Keishi
K
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002908:Chronic Disease; D003094:Collagen / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000378:metabolism; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism*; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D010024:Osteoporosis / Q000209:etiology; D018384:Oxidative Stress; D012306:Risk
D017127:Glycation End Products, Advanced; D006710:Homocysteine; D003094:Collagen; D001120:Arginine; C062187:pentosidine; D008239:Lysine