Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice.
Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus.
Li
Bin
B
Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
Wanka
Lukas
L
Blanchard
Julie
J
Liu
Fei
F
Chohan
Muhammad Omar
MO
Iqbal
Khalid
K
Grundke-Iqbal
Inge
I
D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000375:Aging / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D018891:Dentate Gyrus / Q000187:drug effects; D053605:Leukemia Inhibitory Factor / Q000378:metabolism; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009414:Nerve Growth Factors / Q000737:chemistry / Q000494:pharmacology*; D055495:Neurogenesis / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D021641:Recognition, Psychology / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D013569:Synapses / Q000187:drug effects* / Q000378:metabolism
D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D009414:Nerve Growth Factors; D009842:Oligopeptides; C000608789:P021 peptide; D000218:Adamantane