title: Novel, one-pot, three-component route to indol-3-yl substituted spirooxindole derivatives.
abstract: A simple and efficient approach to the synthesis of a novel series of polysubstituted 6'-(1H-indol-3-yl)-1',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2-one derivatives in high yields was developed from a one-pot, three-component reaction of 3-cyanoacetyl indoles, isatins, and 1H-pyrazol-5-amines in H(2)O/HOAc.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007510:Isatin / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C542126:1H-pyrazol-5-amine; D007211:Indoles; D011720:Pyrazoles; D013141:Spiro Compounds; D007510:Isatin