Alterations on monoamines concentration in rat hippocampus produced by lipoic acid.
The purposes of the present study were to verify monoamines (dopamine (DA), norepinephrine (NE), serotonin (5-HT)), and their metabolites (3,4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA)) contents in rat hippocampus after lipoic acid (LA) administration. Wistar rats were treated with 0.9% saline (i.p., control group) and LA (10, 20 or 30 mg/kg, i.p., LA10, LA20 and LA30 groups, respectively). After the treatments all groups were observed for 24 h. The NE and DA levels were increased only in 20 mg/kg dose of LA in rat hippocampus. Serotonin content and in their metabolite 5-HIAA levels was decreased in same dose of LA. On the other hand, in DOPAC and HVA levels did not show any significant change. The alterations in hippocampal monoamines can be suggested as a possible of brain mechanism of action from this antioxidant. The outcome of the study may have therapeutic implications in the treatment of neurodegenerative diseases.
Santos
Itala Mônica de Sales
IM
Laboratory of Experimental Research in Biological Sciences, Federal University of Piaui, Picos, PI, Brazil.
Freitas
Rizângela Lyne Mendes de
RL
Saldanha
Gláucio Barros
GB
Tomé
Adriana da Rocha
Ada R
Jordán
Joaquín
J
Freitas
Rivelilson Mendes de
RM
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000494:pharmacology*
D000975:Antioxidants; D015306:Biogenic Monoamines; D008063:Thioctic Acid