A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents.
A labdane diterpene dialdehyde was first time isolated from the chloroform extract of rhizomes of Curcuma amada. This compound exhibited antitubercular activity (MIC=500 microg/mL) against Mycobacterium tuberculosis H(37)Rv strain in BACTEC-460 assay. Two of its semisynthetic analogues also exhibited antitubercular activity at 250-500 microg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada.
Singh
Sailendra
S
Plant Tissue Culture Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India.
Kumar
Jonnala Kotesh
JK
Saikia
Dharmendra
D
Shanker
Karuna
K
Thakur
Jay Prakash
JP
Negi
Arvind Singh
AS
Banerjee
Suchitra
S
D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D030024:Curcuma / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects
D000995:Antitubercular Agents; D004224:Diterpenes