The burden of uterine fibroids in five European countries.
OBJECTIVE
To quantify the burden of uterine fibroids (UF) on health-related quality of life (HRQOL) and work productivity in a general population of women.


METHODS
Women diagnosed with or experiencing UF-related symptoms living in five Western European countries (France, Germany, Italy, Spain, and the United Kingdom) were identified through a cross-sectional Internet-based survey. The following parameters and outcomes of interest were captured and analysed: patient history and demographics, treatment and diagnosis patterns, symptom severity and HRQOL, work productivity and activity impairment, and disease or symptom-related health care resource use for the past year (e.g., provider visits, hospitalisation).


RESULTS
This analysis included 1756 women (France, 358; Germany, 345; Italy, 351; Spain, 352; United Kingdom, 350). Prevalence of a diagnosis of UF ranged from 11.7% to 23.6%, and that of undiagnosed bleeding symptoms from 14.7% to 24.6% across the five countries. Between 9.0% and 32.5% of women waited > or =5 years before seeking treatment for UF. Mean UFS-QOL symptom severity scores ranged from 24.7 (95% confidence interval [CI], 21.1-28.3) to 37.6 (95% CI, 32.2-43.0; P<0.001), suggesting mild to moderate severity. Mean UFS-QOL scores ranged from 59.2 (95% CI, 54.2-64.2) to 69.7 (95% CI, 66.5-73.0; P=0.002), suggesting moderate impairment. In pooled analyses, absenteeism was reported by 32.7% of employed women with a diagnosis of UF. Overall worker productivity was reduced by 36.1% and general activity was impaired by 37.9%.


CONCLUSIONS
UF are common in women residing in Western Europe. They are associated with impairment of HRQOL and productivity. A substantial number of women delay seeking medical help. Encouraging symptomatic women to seek help and treatment earlier may benefit women by improving their HRQOL and may also benefit society through enhanced worker productivity.
Downes
Ellis
E
Barnet and Chase Farm Hospitals NHS Trust, The Ridgeway, Enfield EN2 8JL, United Kingdom.
Sikirica
Vanja
V
Gilabert-Estelles
Juan
J
Bolge
Susan C
SC
Dodd
Sheri L
SL
Maroulis
Christine
C
Subramanian
Dhinagar
D
D000328:Adult; D003430:Cross-Sectional Studies; D004526:Efficiency; D005060:Europe / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology*; D008875:Middle Aged; D015995:Prevalence; D011788:Quality of Life; D016896:Treatment Outcome; D047368:Tumor Burden; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology*