title: The targets of CAPRI Rounds 13-19.
abstract: Seven rounds of CAPRI predictions with a total of 14 targets were held in the period June 2007-November 2009. In addition to protease/inhibitor complexes and complexes with G-proteins, some of the targets displayed novel features presenting new challenges to the predictors: a complex with RNA, a leucine zipper to be built ab initio, and a human-designed protein. Nine targets were unbound or required model building; the other five had a bound component. Thirteen were assessed, and the results show that the predictor and scorer groups submitted two- or three-star (medium or high quality) models for eight of them, one-star (acceptable) models for three but failed on the unbound RNA complex and another unbound target.
authors.affiliation: Yeast Structural Genomics, IBBMC, Université Paris-Sud, Orsay, France. joel.janin@u-psud.fr
authors.forename: Joël
authors.initials: J
authors.lastname: Janin
mesh_terms: D000465:Algorithms; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D012984:Software
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D004798:Enzymes; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins