Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis.
Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.
Pelayo-Terán
José María
JM
Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla-IFIMAV, School of Medicine, University of Cantabria, Santander, Spain.
Pérez-Iglesias
Rocío
R
Vázquez-Bourgon
Javier
J
Mata
Ignacio
I
Carrasco-Marín
Eugenio
E
Vázquez-Barquero
José Luis
JL
Crespo-Facorro
Benedicto
B
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004252:DNA Mutational Analysis; D004311:Double-Blind Method; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D012044:Regression Analysis; D016896:Treatment Outcome; D014633:Valine / Q000235:genetics*; D055815:Young Adult
D014150:Antipsychotic Agents; D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine