Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).
A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA.
Yang
John
J
Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA.
Marriner
Gwendolyn A
GA
Wang
Xinyu
X
Bowman
Phillip D
PD
Kerwin
Sean M
SM
Stavchansky
Salomon
S
D002109:Caffeic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line; D019610:Cytoprotection / Q000187:drug effects*; D054879:Halogenation; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010627:Phenethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D014471:Umbilical Veins / Q000166:cytology
D002109:Caffeic Acids; D010627:Phenethylamines; D006861:Hydrogen Peroxide; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol