title: Does improvement management of atopic dermatitis influence the appearance of respiratory allergic diseases? A follow-up study.
abstract: BACKGROUND
  Atopic dermatitis (AD) is often the prelude to allergic diseases. The aim of this study was 1) to evaluate if an integrated management regime could bring about a change in the evolution of the disease in comparison to the results of a previous study; 2) to determine whether the refinement of allergic investigations allowed to identify more promptly the risk factors of evolution into respiratory allergic diseases.
  
  
  METHODS
  The study included 176 children affected by AD and previously evaluated between 1993 and 2002 at the age of 9-16 months, who underwent a telephonic interview by means of a semi-structured, pre-formed questionnaire after a mean follow-up time of 8 years. According to the SCORAD, at first evaluation children had mild AD in 23% of cases, moderate in 62%, severe in 15%.
  
  
  RESULTS
  AD disappeared in 92 cases (52%), asthma appeared in 30 (17%) and rhinoconjunctivitis in 48 (27%). The factors significantly related to the appearance of asthma were: sensitization to food allergens with sIgE > 2 KU/L (cow's milk and hen's egg; P < 0.05); to inhalant allergens with sIgE > 0.35 KU/L (P < 0.05). Logistic regression analysis showed that inhalant sensitization was positively related to the occurrence of asthma (OR = 4.219). While AD showed similar rates of disappearance to those of our previous study, the incidence of asthma was reduced, at the same follow-up time, from 29% to 15% (P = 0.002), and the incidence of rhinoconjunctivitis from 35% to 24% (P = 0.02).
  
  
  CONCLUSIONS
  Comparing the results with those of the previous study, integrated management of AD does not seem to influence its natural course. Nevertheless, the decrease in the percentage of children evolving towards respiratory allergic disease stresses the importance of early diagnosis and improvement management carried out by specialist centers. The presence of allergic sensitization at one year of age might predict the development of respiratory allergy.
authors.affiliation: Department of Pediatrics, University of Bologna, Italy. giampaolo.ricci@unibo.it.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Ricci
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
authors.forename: Arianna
authors.initials: A
authors.lastname: Giannetti
authors.forename: Arianna
authors.initials: A
authors.lastname: Dondi
authors.forename: Barbara
authors.initials: B
authors.lastname: Bendandi
authors.forename: Massimo
authors.initials: M
authors.lastname: Masi