title: Primary strumal carcinoid tumor of the ovary with multiple bone and breast metastases.
abstract: Although primary carcinoid tumor of the ovary is an extremely rare neoplasm, survival is excellent if the disease is confined to one ovary. Herein, we present a case of primary strumal carcinoid tumor of the ovary, stage IA, borderline malignancy, in a 34-year-old woman. Histological findings of the right ovary indicated higher atypical nuclei, higher mitotic rate and focal necrosis of tumorous cells in some areas, findings that are compatible with atypical carcinoid of the lung. Immunohistochemical staining was positive for synaptophysin, neuron-specific enolase, chromogranin A, Ki-67, topoisomerase IIalpha, peptide YY, and thyroglobulin. Three and a half years postoperatively, multiple bone and breast metastases were found and anticancer chemotherapy was ineffective. The results in the present case indicate that an ovarian carcinoid tumor found to be 'atypical carcinoid' according to pulmonary carcinoid criteria or immunohistochemical staining (i.e. highly positive for topoisomerase IIalpha and Ki-67) may have a poor prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, Niigata City General Hospital, Chuo-ku, Niigata, Japan. takumi@hosp.niigata.niigata.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Kurabayashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Minamikawa
authors.forename: Shota
authors.initials: S
authors.lastname: Nishijima
authors.forename: Ikunosuke
authors.initials: I
authors.lastname: Tsuneki
authors.forename: Masaki
authors.initials: M
authors.lastname: Tamura
authors.forename: Toru
authors.initials: T
authors.lastname: Yanase
authors.forename: Hideki
authors.initials: H
authors.lastname: Hashidate
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shibuya
authors.forename: Teiichi
authors.initials: T
authors.lastname: Motoyama
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000556:secondary*; D002276:Carcinoid Tumor / Q000378:metabolism / Q000556:secondary*; D053379:Chromogranin A / Q000378:metabolism; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D013330:Struma Ovarii / Q000378:metabolism / Q000556:secondary*; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D053379:Chromogranin A; D016708:Synaptophysin