title: Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats.
abstract: The present study was designed to evaluate whether the administration of s-methylisothiourea and melatonin has protective potential in intestinal ischemia/reperfusion injury. Forty male Sprague-Dawley rats were divided into five groups. Ileal specimens were obtained to determine the levels of malondialdehyde, protein carbonyl content, levels of antioxidant enzymes and evaluation of histologic changes. Combination of s-methylisothiourea and melatonin, led to a statistically significant increase in activities of antioxidant enzymes with a decrease in malondialdehyde and protein carbonyl content and intestinal mucosal injury scores. It was shown; combination of SMT and melatonin may exert more promised results.
authors.affiliation: Department of Pediatrics, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey. drturantunc@yahoo.com
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: Hilmi
authors.initials: H
authors.lastname: Demirin
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Karaoglu
authors.forename: Vural
authors.initials: V
authors.lastname: Kesik
authors.forename: Abdulkerim
authors.initials: A
authors.lastname: Temiz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozler
authors.forename: Serdar
authors.initials: S
authors.lastname: Sadir
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Atabek
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kul
authors.forename: Emin
authors.initials: E
authors.lastname: Oztas
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D007082:Ileum / Q000187:drug effects / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D007550:Isothiuronium; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C027744:S-methylisothiopseudouronium; D008550:Melatonin