Biomimetics for the induction of bone formation.
The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-beta supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.
Ripamonti
Ugo
U
Medical Research Council/University of the Witwatersrand, Johannesburg, 2193 Parktown, South Africa. ugo.ripamonti@wits.ac.za
Roden
Laura
L
D000818:Animals; D040761:Biomimetic Materials / Q000494:pharmacology*; D001857:Bone Matrix / Q000187:drug effects; D001842:Bone and Bones / Q000473:pathology; D006801:Humans; D009024:Morphogenesis / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D023822:Tissue Engineering