Pulmonary ventilation and perfusion imaging with dual-energy CT.
OBJECTIVE
To evaluate the feasibility of dual-energy CT (DECT) ventilation imaging in combination with DE perfusion mapping for a comprehensive assessment of ventilation, perfusion, morphology and structure of the pulmonary parenchyma.


METHODS
Two dual-energy CT acquisitions for xenon-enhanced ventilation and iodine-enhanced perfusion mapping were performed in patients under artificial respiration. Parenchymal xenon and iodine distribution were mapped and correlated with structural or vascular abnormalities.


RESULTS
In all datasets, image quality was sufficient for a comprehensive image reading of the pulmonary CTA images, lung window images and pulmonary functional parameter maps and led to expedient results in each patient.


CONCLUSIONS
With dual-source CT systems, DECT of the lung with iodine or xenon administration is technically feasible and makes it possible to depict the regional iodine or xenon distribution representing the local perfusion and ventilation.
Thieme
Sven F
SF
Department of Clinical Radiology, Ludwig Maximilians University, Klinikum Großhadern, Marchioninistr. 15, 81377, München, Germany. sven.thieme@med.lmu.de
Hoegl
Sandra
S
Nikolaou
Konstantin
K
Fisahn
Juergen
J
Irlbeck
Michael
M
Maxien
Daniel
D
Reiser
Maximilian F
MF
Becker
Christoph R
CR
Johnson
Thorsten R C
TR
D000328:Adult; D000368:Aged; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D012123:Pulmonary Ventilation; D015900:Radiography, Dual-Energy Scanned Projection / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014978:Xenon
D003287:Contrast Media; D014978:Xenon