The (r)evolution of cancer genetics.
The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards perturbation. A recent paper published in BMC Biology shows how the founder domains of known cancer genes emerged at two macroevolutionary transitions - the advent of the first cell and the transition to metazoan multicellularity. See research article http://www.biomedcentral.com/1741-7007/8/66.
Ciccarelli
Francesca D
FD
Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, 20139 Milan, Italy. francesca.ciccarelli@ifom-ieo-campus.it
D000818:Animals; D019143:Evolution, Molecular; D052138:Genes, Neoplasm / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008957:Models, Genetic