title: Integrative genomic profiling of human prostate cancer.
abstract: Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Barry S
authors.initials: BS
authors.lastname: Taylor
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Schultz
authors.forename: Haley
authors.initials: H
authors.lastname: Hieronymus
authors.forename: Anuradha
authors.initials: A
authors.lastname: Gopalan
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Xiao
authors.forename: Brett S
authors.initials: BS
authors.lastname: Carver
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Arora
authors.forename: Poorvi
authors.initials: P
authors.lastname: Kaushik
authors.forename: Ethan
authors.initials: E
authors.lastname: Cerami
authors.forename: Boris
authors.initials: B
authors.lastname: Reva
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Antipin
authors.forename: Nicholas
authors.initials: N
authors.lastname: Mitsiades
authors.forename: Thomas
authors.initials: T
authors.lastname: Landers
authors.forename: Igor
authors.initials: I
authors.lastname: Dolgalev
authors.forename: John E
authors.initials: JE
authors.lastname: Major
authors.forename: Manda
authors.initials: M
authors.lastname: Wilson
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Socci
authors.forename: Alex E
authors.initials: AE
authors.lastname: Lash
authors.forename: Adriana
authors.initials: A
authors.lastname: Heguy
authors.forename: James A
authors.initials: JA
authors.lastname: Eastham
authors.forename: Howard I
authors.initials: HI
authors.lastname: Scher
authors.forename: Victor E
authors.initials: VE
authors.lastname: Reuter
authors.forename: Peter T
authors.initials: PT
authors.lastname: Scardino
authors.forename: Chris
authors.initials: C
authors.lastname: Sander
authors.forename: Charles L
authors.initials: CL
authors.lastname: Sawyers
authors.forename: William L
authors.initials: WL
authors.lastname: Gerald
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D055028:Comparative Genomic Hybridization; D018628:Gene Dosage; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D009362:Neoplasm Metastasis; D020411:Oligonucleotide Array Sequence Analysis; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; C515553:TMPRSS2-ERG fusion protein, human