title: Cerebral and functional adaptation with chronic hypoxia exposure: a multi-modal MRI study.
abstract: The current study obtained multi-modal MRI data from 28 immigrant high altitude (HA) young adults who were born and grew up at Qinghai-Tibetan plateau matched with 28 matched sea level (SL) controls. We compared their regional gray matter volumes (VBM) and white matter quality (DAI FA values) as well as resting state brain activity (Regional Homogeneity (ReHo) of BOLD-fMRI). We found that HA residents showed decreased gray matter volume at bilateral anterior insula, bilateral prefrontal cortex, the left precentral, the left cingulate and the right lingual cortex; accompanied by changed FA and ReHo values in relevant and other regions. The resting state activity at the hippocampus and the right insula were increasing with SL relocation. The HA subjects performed worse on a series of working memory tasks, with the ReHo values of several regions as significant predictors of their performance. This study demonstrated the cerebral and functional modifications with chronic high altitude hypoxia.
authors.affiliation: Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Yan
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Zhang
authors.forename: Jinfu
authors.initials: J
authors.lastname: Shi
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.forename: Xuchu
authors.initials: X
authors.lastname: Weng
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D012044:Regression Analysis; D055815:Young Adult