title: Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus.
abstract: A series of beta-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL(4.3) virus. 1-Formyl-beta-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC(50)=2.9 microM.
authors.affiliation: Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India.
authors.forename: Keyur G
authors.initials: KG
authors.lastname: Brahmbhatt
authors.forename: Nafees
authors.initials: N
authors.lastname: Ahmed
authors.forename: Sudeep
authors.initials: S
authors.lastname: Sabde
authors.forename: Debashis
authors.initials: D
authors.lastname: Mitra
authors.forename: Inder Pal
authors.initials: IP
authors.lastname: Singh
authors.forename: Kamlesh K
authors.initials: KK
authors.lastname: Bhutani
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D005561:Formates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans
chemical_list: C553254:1-formyl-beta-carboline-3-carbxylic acid methyl ester; D019380:Anti-HIV Agents; D002243:Carbolines; D005561:Formates