Subcompartmentalized polymer hydrogel capsules with selectively degradable carriers and subunits.
Subcompartmentalized hydrogel capsules (SHCs) with selectively degradable carriers and subunits are designed for potential applications in drug delivery and microencapsulated biocatalysis. Thiolated poly(methacrylic acid) and poly(N-vinyl pyrrolidone) are used to assemble 3-microm-diameter carrier capsules and 300-nm-diameter subunits, independently stabilized by a diverse range of covalent linkages. This paper presents examples of SHCs with tens of subcompartments and their successful drug loading, as well as selective degradation of the SHC carrier and/or subunits in response to multiple chemical stimuli.
Kulygin
Olga
O
Centre for Nanoscience and Nanotechnology Department of Chemical and Biomolecular Engineering The University of Melbourne Parkville, Victoria, Australia.
Price
Andrew D
AD
Chong
Siow-Feng
SF
Städler
Brigitte
B
Zelikin
Alexander N
AN
Caruso
Frank
F
D055162:Biocatalysis; D004337:Drug Carriers; D020100:Hydrogels / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D004337:Drug Carriers; D020100:Hydrogels; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); C030613:polymethacrylic acid