"Atypical steroid response" in a pulmonary inflammatory myofibroblastic tumor.
A 6-year-old girl was evaluated for the presence of a paratracheal mass with right upper lobe atelectasis due to an endobronchial mass. Bronchoscopic biopsy established a diagnosis of inflammatory myofibroblastic tumor (IMT) and prednisone initially led to a significant reduction of the endobronchial lesion. However, 8 weeks later, when still on prednisone, the mediastinal mass enlarged dramatically. At thoracotomy, a well-circumscribed, multilobulated mass was partially resected and a diagnosis of IMT confirmed. Immunosuppression by corticosteroids may have favored the rapid progression of this apparently benign, indolent tumor.
Sacco
Oliviero
O
Giannina Gaslini Research Institute, Genova, Italy.
Gambini
Claudio
C
Gardella
Chiara
C
Tomà
Paolo
P
Rossi
Umberto G
UG
Jasonni
Vincenzo
V
Bush
Andrew
A
Rossi
Giovanni A
GA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D008477:Mediastinal Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008727:Methotrexate / Q000627:therapeutic use; D009379:Neoplasms, Muscle Tissue / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D001261:Pulmonary Atelectasis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000627:therapeutic use
D014747:Vinblastine; D011241:Prednisone; D008727:Methotrexate