Intravitreal bevacizumab in choroidal neovascularization associated with congenital choroidal and optic nerve coloboma in children: long-term improvement in visual acuity.
Choroidal neovascular membranes are a rare cause of decreased vision in children with congenital choroidal and optic nerve colobomas. We report on the regression of coloboma-related choroidal neovascular membranes in 2 children treated with intravitreal bevacizumab. Visual acuity remained improved in both children 2 years after the last injection.
Naithani
Prashant
P
Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. drprashnatnaithani@yahoo.co.in
Vashisht
Naginder
N
Mandal
Subrata
S
Sankaran
Preeti
P
Garg
Satpal
S
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D002648:Child; D002675:Child, Preschool; D020256:Choroidal Neovascularization / Q000150:complications / Q000151:congenital / Q000188:drug therapy; D003103:Coloboma / Q000150:complications*; D005260:Female; D006801:Humans; D056965:Injections, Intraocular; D009900:Optic Nerve / Q000002:abnormalities*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab