Manipulation of dendritic cell function by viruses.
Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread, survival and transmission. This review summarises recently published work identifying how viruses alter the expression of receptors, antiviral molecules, disrupt signalling pathways, subvert trafficking pathways and even affect DC function via interactions with second or third cell types. Different viruses such as human immunodeficiency virus (HIV) and herpes viruses may have widely divergent and even opposite effects on DC function, determined by the need for transfer to a primary target cell, replication within the DC or various immunoevasive mechanisms.
Cunningham
Anthony L
AL
Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW 2145, Australia. tony_cunningham@wmi.usyd.edu.au
Donaghy
Heather
H
Harman
Andrew N
AN
Kim
Min
M
Turville
Stuart G
SG
D000818:Animals; D001692:Biological Transport / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D011991:Receptors, Virus / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000821:virology*; D053586:Virus Internalization; D014779:Virus Replication / Q000276:immunology; D014780:Viruses / Q000276:immunology*
D011991:Receptors, Virus