Catalytic enantioselective synthesis of sterically demanding alcohols using di(2 degrees -alkyl)zinc prepared by the refined Charette's method.
A highly practical, catalytic enantioselective 2 degrees -alkyl addition to aldehydes and ketones was developed. Chiral phosphoramide ligand (1) with salt-free and solvent-free di(2 degrees -alkyl)zinc reagents prepared from (2 degrees -alkyl)MgCl was essential.
Hatano
Manabu
M
Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
Mizuno
Tomokazu
T
Ishihara
Kazuaki
K