Facing towards epidermal stem cells (Review).
Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation and regeneration potential to the tissues in which they reside. This review focused on epidermal stem cells (ESCs). These cells are distinguished from transitory amplifier cells and post-mitotic cells. ESC are found in the interadnexal epidermis and in the bulge region of hair follicles. A series of ESCs markers are available, but increased sensitivity and specificity require further development.
Schreder
Anelaure
A
Department of Dermatopathology, University Hospital Sart Tilman, B-4000 Liège, Belgium.
Pierard
Gerald E
GE
Paquet
Philippe
P
Reginster
Marie-Annick
MA
Pierard-Franchimont
Claudine
C
Quatresooz
Pascale
P
D000818:Animals; D015415:Biomarkers; D000078404:Epidermal Cells; D018859:Hair Follicle / Q000166:cytology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D039902:Multipotent Stem Cells
D015415:Biomarkers