Development of secondary T-cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis.
Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, characterized by hyperactivation of macrophages. A 12-year-old female was referred to our center; the diagnosis of HLH was made for the patient and immunosuppressive regimen was started. After a 2-year follow-up, the patient developed secondary T-cell acute lymphoblastic leukemia (T-ALL), confirmed by flow cytometric studies. Treatment was started based on T-ALL protocol, but the patient died because of relapse and sepsis. This case highlights the issue of secondary malignancy following HLH and demonstrates the need for continued follow-up in such patients.
Shamsian
Bibi Shahin
BS
Department of Pediatric Hematology-Oncology, Mofid Children's Hospital, Shahid Beheshti Medical University, Tehran, Iran. shamsianb@yahoo.com
Gharib
Atoosa
A
Rezaei
Nima
N
Esfahani
Shadi Abdar
SA
Alavi
Samin
S
Goudarzipour
Kourosh
K
Arzanian
Mohammad Taghi
MT
D002648:Child; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*