title: Experimental determination of minimal stimulation current and period for electrical thrombosis in dogs.
abstract: Endovascular surgery has been proposed as an alternative treatment for cerebral aneurysms. However, for wide neck and large sized lesions it is very difficult to obtain complete occlusion and tissue organization. The present study was conducted to examine the efficacy of electrical thrombosis for cerebral aneurysms and parent arterial occlusions using Interlocking Detachable Coils (IDCs), focusing on the minimum current volume and stimulation time required for stable electrical thrombosis formation. We used ten mixed-breed adult dogs (in the study body weights 9-12 kg; males: 5, females: 5). Guiding catheter sand microcatheters were introduced into both sides of the distal external carotid artery (ECA) and placed at the same level. To prevent migration, IDCs (4 mm x 12 cm) were placed in the ECA without being detached. After confirming no vessel occlusion, we applied a positive current (2-6 mA) to the coil on one side and performed angiography every ten minutes to observe whether vessel occlusion with electrothrombosis had occurred. It was determined that to achieve complete occlusion of the external carotid arteries in mixedbreed dogs, a minimum stimulation current of 4mA and a minimum stimulation time of ten to 20 minutes are required.
authors.affiliation: Department of Neurosurgery and the Animal Center; Kitasato University School of Medicine, Kanagawa; Japan - ssachio@med.kitasato-u.ac.jp.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Kurata
authors.forename: T
authors.initials: T
authors.lastname: Ohmomo
authors.forename: H
authors.initials: H
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: H
authors.initials: H
authors.lastname: Hirayama
authors.forename: Y
authors.initials: Y
authors.lastname: Yasui
authors.forename: K
authors.initials: K
authors.lastname: Fujii