Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.
A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.
Sparapani
Silvia
S
Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London, WC1N 1AX, UK.
Bellini
Stefania
S
Gunaratnam
Mekala
M
Haider
Shozeb M
SM
Andreani
Aldo
A
Rambaldi
Mirella
M
Locatelli
Alessandra
A
Morigi
Rita
R
Granaiola
Massimiliano
M
Varoli
Lucilla
L
Burnelli
Silvia
S
Leoni
Alberto
A
Neidle
Stephen
S
D003198:Computer Simulation; D004247:DNA / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D011743:Pyrimidines / Q000737:chemistry*
D011743:Pyrimidines; C553797:bis-guanylhydrazone diimidazo(1,2-a-1,2-c)pyrimidine; D004247:DNA; D008935:Mitoguazone