title: Role of Kruppel-like factors in leukocyte development, function, and disease.
abstract: The Krüppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, autoimmunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Krüppel-like factors in leukocyte biology and their implications in clinical settings.
authors.affiliation: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Zhuoxiao
authors.initials: Z
authors.lastname: Cao
authors.forename: Xinghui
authors.initials: X
authors.lastname: Sun
authors.forename: Basak
authors.initials: B
authors.lastname: Icli
authors.forename: Akm Khyrul
authors.initials: AK
authors.lastname: Wara
authors.forename: Mark W
authors.initials: MW
authors.lastname: Feinberg
mesh_terms: D000818:Animals; D015870:Gene Expression; D006410:Hematopoiesis; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D051741:Kruppel-Like Transcription Factors