title: Tetracycline and niacinamide control bullous pemphigoid but not pemphigus foliaceus when these conditions coexist.
abstract: Pemphigus and pemphigoid are different types of autoimmune bullous disease and can occur in the same patient. We report a female patient with this condition. At first, we diagnosed her with bullous pemphigoid, and we treated her with tetracycline, niacinamide and a topical steroid. Tense bullas disappeared shortly after that, but crusted erythemas mainly on her head and trunk persisted. We examined BP180 and desmoglein 1 enzyme-linked immunosorbent assays, and also histological features, which showed coexistence of bullous pemphigoid and pemphigus foliaceus concurrently. Therefore, we tried prednisolone, which could control both conditions. This case showed that tetracycline and niacinamide could control bullous pemphigoid, but could not control pemphigus foliaceus, and that prednisolone was effective for both conditions.
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. junshio@okaya-hosp.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Shiohara
authors.forename: Kanako
authors.initials: K
authors.lastname: Yoshida
authors.forename: Junichi
authors.initials: J
authors.lastname: Hasegawa
authors.forename: Hisashi
authors.initials: H
authors.lastname: Uhara
authors.forename: Minoru
authors.initials: M
authors.lastname: Takata
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saida
authors.forename: Bungo
authors.initials: B
authors.lastname: Ohyama
authors.forename: Bungo
authors.initials: B
authors.lastname: Oyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D001324:Autoantigens / Q000032:analysis; D051183:Desmoglein 1 / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D024041:Non-Fibrillar Collagens / Q000032:analysis; D010391:Pemphigoid, Bullous / Q000188:drug therapy* / Q000473:pathology; D010392:Pemphigus / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use*; D000097805:Collagen Type XVII
chemical_list: D001324:Autoantigens; D051183:Desmoglein 1; D009536:Niacinamide; D024041:Non-Fibrillar Collagens; D011239:Prednisolone; D013752:Tetracycline; D000097805:Collagen Type XVII