title: Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line.
abstract: The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERbeta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.
authors.affiliation: Chemical Synthesis Group, Amity Institute of Biotechnology, Amity University Sector 125, Noida, India. sbhatnagar@aib.amity.edu
authors.forename: Seema
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: Shakti
authors.initials: S
authors.lastname: Sahi
authors.forename: Puneet
authors.initials: P
authors.lastname: Kackar
authors.forename: Swati
authors.initials: S
authors.lastname: Kaushik
authors.forename: Manan K
authors.initials: MK
authors.lastname: Dave
authors.forename: Akshara
authors.initials: A
authors.lastname: Shukla
authors.forename: Ashita
authors.initials: A
authors.lastname: Goel
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001665:Binding Sites; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D003198:Computer Simulation; D015195:Drug Design; D047629:Estrogen Receptor beta / Q000737:chemistry; D005260:Female; D006801:Humans; D013343:Styrenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D002867:Chromones; D047629:Estrogen Receptor beta; D013343:Styrenes