title: Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups.
abstract: Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl)phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.forename: Fujie
authors.initials: F
authors.lastname: Chen
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Zhong
authors.forename: Renxi
authors.initials: R
authors.lastname: Zhuo
mesh_terms: D000818:Animals; D001897:Boronic Acids / Q000737:chemistry*; D019556:COS Cells; D002522:Chlorocebus aethiops; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D011094:Polyethyleneimine / Q000737:chemistry*; D014162:Transfection / Q000379:methods*
chemical_list: D001897:Boronic Acids; D005456:Fluorescent Dyes; D011094:Polyethyleneimine; D016650:Fluorescein-5-isothiocyanate; C010686:benzeneboronic acid