title: Well-differentiated endocrine cell carcinoma of ileum treated by laparoscopy-assisted surgery--a case report.
abstract: A 72-year-old woman presented at our hospital with a 1-year history of intermittent right lower abdominal pain. Colonoscopic examination revealed a submucosal tumor with a pitted surface in the terminal ileum. Histopathological diagnosis of the carcinoid tumor was made following biopsy. Blood serotonin and urine 5-hydroxy-indoleacetic acid levels were normal, and carcinoid syndrome was not detected. Enhanced abdominal computed tomography scan and 18F-fluorodeoxyglucose positron emission tomography failed to detect multiple lesions, lymph node swelling or distant metastasis. Laparoscopy-assisted ileocecal resection with lymph node dissection was performed. The resected specimen showed a submucosal tumor with a pitted surface 11 x 11 mm in size, located at the terminal ileum. Histopathological examination revealed a well-differentiated endocrine cell carcinoma with an invasion depth to the muscularis propria. Immunohistochemical analysis showed the tumor cells to be chromogranin A and CD56-positive. The patient had no sign of recurrence for 16 months.
authors.affiliation: Department of Surgery, Hiroshima City Hospital, 7-33 Moto-machi, Naka-ku, Hiroshima 730-8518, Japan. sasachy@yahoo.co.jp
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sasada
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ojima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nishizaki
authors.forename: Masao
authors.initials: M
authors.lastname: Harano
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Aoki
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Shiozaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Motoki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Hiroo
authors.initials: H
authors.lastname: Matsuura
authors.forename: Norihisa
authors.initials: N
authors.lastname: Takakura
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D004701:Endocrine Gland Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology*; D010535:Laparoscopy; D014057:Tomography, X-Ray Computed