title: Outcome of children with life-threatening asthma necessitating pediatric intensive care.
abstract: OBJECTIVE
  To report the outcome of children with life-threatening asthma (LTA) admitted to a university Pediatric Intensive Care Unit (PICU).
  
  
  METHODS
  Retrospective study between October 2002 and May 2010 was carried out. Every child with LTA and bronchospasm was included.
  
  
  RESULTS
  30 admissions of 28 patients (13 M, 17 F) were identified which accounted for 3% of total PICU admissions (n = 1033) over the study period. The majority of patients were toddlers (median age 3.1 years). Few had past history of prematurity, lung diseases, or neuro-developmental conditions. Approximately half had previous admissions for asthma and one-forth with history of non-compliance to recommended treatment for asthma. One patient had parainfluenza virus and one had rhinovirus isolated. None of these factors were associated with need for mechanical ventilation (n = 6 admissions). Comparing with patients who did not receive mechanical ventilation, ventilated children had significantly higher PIM2 score (1.65 versus 0.4, p < 0.001), higher PCO2 levels (9.3 kPa versus 5.1 kPa, p = 0.01) and longer PICU stay (median 2.5 days versus 2 days, p = 0.03) The majority of patients received systemic corticosteroids, intravenous or inhaled bronchodilators. There was one pneumothorax but no death in this series.
  
  
  CONCLUSIONS
  LTA accounted for a small percentage of PICU admissions. Previous hospital admissions for asthma and history of non-compliance were common. Approximately one quarters required ventilatory supports. Regardless of the need for mechanical ventilation, all patients survived with prompt treatment.
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong. ehon@hotmail.com
authors.forename: Kam-Lun
authors.initials: KL
authors.lastname: Hon
authors.forename: Wing-Sum Winnie
authors.initials: WS
authors.lastname: Tang
authors.forename: Ting-Fan
authors.initials: TF
authors.lastname: Leung
authors.forename: Kam-Lau
authors.initials: KL
authors.lastname: Cheung
authors.forename: Pak-Cheung
authors.initials: PC
authors.lastname: Ng
mesh_terms: D000280:Administration, Inhalation; D001249:Asthma / Q000175:diagnosis / Q000628:therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006785:Hospitals, University; D006801:Humans; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D012121:Respiration, Artificial / Q000379:methods*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D001993:Bronchodilator Agents; D005938:Glucocorticoids