Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection.
Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.
Ben-Ami
Ronen
R
Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Lewis
Russell E
RE
Kontoyiannis
Dimitrios P
DP
D056704:Adaptive Immunity; D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology / Q000472:pathogenicity*; D055808:Drug Discovery / Q000379:methods; D005912:Gliotoxin / Q000378:metabolism; D006801:Humans; D057131:Immune Evasion; D018928:Immunity, Mucosal; D016867:Immunocompromised Host; D013312:Stress, Physiological / Q000502:physiology
D000935:Antifungal Agents; D005912:Gliotoxin