title: Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy.
abstract: OBJECTIVE
  Talin 2 plays an important role in cell adhesion and recycling of synaptic vesicles. To explore the possible role of talin 2 in epilepsy, we designed current study to quantitatively evaluate the changes in talin 2 levels in different epilepsy patients.
  
  
  METHODS
  We measured talin 2 levels in CSF and the serum of postencephalitic epilepsy (PEE) patients (subdivided into drug-refractory PEE-RPEE, and drug-effective PEE-EPEE groups) and acute encephalitis patients (subdivided into acute encephalitis with secondary seizures-AESS, and acute encephalitis without seizures-AE) by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  We found that, in RPEE patients, interictal CSF-talin 2 concentrations significantly increased, whereas serum-talin 2 significantly decreased when compared with the AE, AESS, and EPEE groups.
  
  
  CONCLUSIONS
  This result suggested that the differential concentration of CSF and serum-talin 2 in the RPEE group is an intractability-related phenomenon that might be involved in the development of RPEE.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiao
authors.forename: Lan
authors.initials: L
authors.lastname: Shen
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Xi
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004351:Drug Resistance; D004660:Encephalitis / Q000134:cerebrospinal fluid; D004827:Epilepsy / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000134:cerebrospinal fluid; D016608:Talin / Q000097:blood / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: C436513:TLN2 protein, human; D016608:Talin