title: Genomic predictors of prostate cancer therapy outcomes.
abstract: Although numerous attempts have been made to forecast outcomes for prostate cancer after therapy using clinical and histological variables, the ability to accurately predict an individual's response to a specific treatment remains elusive. Recently, major advances in the field of genomics have made possible the near-comprehensive assessment of the genetic status of tumor genomes, with major concentration on predicting an individual's response to a specific treatment. Genomic approaches to treatment response include, but are not limited to, detection of gene rearrangements, DNA copy-number aberrations, single-nucleotide polymorphisms, epigenetic changes and differential gene-expression patterns. These approaches have been used to predict response to treatment for local and systemic disease in multiple small cohorts. Further study with larger cohorts and longer follow-up should result in more concordance among genomic approaches, and will enable physicians to gain insight into the heterogeneity of supposedly 'similar' cancers and help tailor treatments accordingly.
authors.affiliation: Division of Urology, Virginia Mason Medical Center, Seattle, WA, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lewinshtein
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Porter
authors.forename: Peter S
authors.initials: PS
authors.lastname: Nelson
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D051059:PTEN Phosphohydrolase / Q000235:genetics; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D035683:MicroRNAs; D015514:Oncogene Proteins, Fusion; C529660:TMPRSS2-ETS fusion protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human