Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition.
The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia.
Aleksandrova
Krasimira
K
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. krasimira.aleksandrova@dife.de
Jenab
Mazda
M
Boeing
Heiner
H
Jansen
Eugene
E
Bueno-de-Mesquita
H Bas
HB
Rinaldi
Sabina
S
Riboli
Elio
E
Overvad
Kim
K
Dahm
Christina C
CC
Olsen
Anja
A
Tjønneland
Anne
A
Boutron-Ruault
Marie-Christine
MC
Clavel-Chapelon
Françoise
F
Morois
Sophie
S
Palli
Domenico
D
Krogh
Vittorio
V
Tumino
Rosario
R
Vineis
Paolo
P
Panico
Salvatore
S
Kaaks
Rudolf
R
Rohrmann
Sabine
S
Trichopoulou
Antonia
A
Lagiou
Pagona
P
Trichopoulos
Dimitrios
D
van Duijnhoven
Fränzel J B
FJ
Leufkens
Anke M
AM
Peeters
Petra H
PH
Rodríguez
Laudina
L
Bonet
Catalina
C
Sánchez
María-José
MJ
Dorronsoro
Miren
M
Navarro
Carmen
C
Barricarte
Aurelio
A
Palmqvist
Richard
R
Hallmans
Göran
G
Khaw
Kay-Tee
KT
Wareham
Nicholas
N
Allen
Naomi E
NE
Spencer
Elizabeth
E
Romaguera
Dora
D
Norat
Teresa
T
Pischon
Tobias
T
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood / Q000453:epidemiology*; D005060:Europe; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D055105:Waist Circumference
D015415:Biomarkers; D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin