title: Association of SF-36 with coronary artery disease risk factors and mortality: a PreCIS study.
abstract: This study examined the relationships among health-related quality of life and risk factors of coronary artery disease (CAD) and all-cause mortality in high-risk cardiac patients seen in a cardiology prevention clinic. At baseline, 1785 patients (age, 53.4+/-13.4 years; 58.8% men) had a medical history, physical examination, and laboratory tests. They completed the Medical Outcomes Study Short Form-36-Item Health Survey (SF-36). Analyses were conducted on associations of 2 SF-36 domain scores (overall physical health [OPH] and overall mental health [OMH]) with CAD biomarkers and all-cause mortality. Lower OPH scores were associated with CAD risk factors including smoking; history of hypertension, diabetes, and peripheral artery disease; the metabolic syndrome; and other novel CAD biomarkers. Lower OMH scores showed similar but weaker associations with CAD risk factors. OPH significantly predicted 5-year mortality in multivariable survival analysis. SF-36, especially OPH, was associated with many risk factors of CAD and significantly predicted mortality.
authors.affiliation: Department of Psychiatry and Psychology, Cleveland Clinic Foundation, Cleveland, OH, USA. jpzhang2005@gmail.com
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Leo
authors.initials: L
authors.lastname: Pozuelo
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Brennan
authors.forename: Brian
authors.initials: B
authors.lastname: Hoar
authors.forename: Byron J
authors.initials: BJ
authors.lastname: Hoogwerf
mesh_terms: D000223:Adaptation, Psychological; D000465:Algorithms; D015415:Biomarkers; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality / Q000523:psychology*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013315:Stress, Psychological; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
chemical_list: D015415:Biomarkers