Pancytopenia associated with clonazepam.
We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently, she was hospitalized for neutropenic fever with thrombocytopenia and worsening anemia. Bone marrow examination demonstrated a markedly hypocellular marrow (10-20% total cellularity). Clonazepam was discontinued, with gradual improvement of thrombocytopenia, and neutropenia in 1-2 weeks. To our knowledge, this is the first reported case of pancytopenia associated with clonazepam. We recommend patients taking clonazepam to be monitored with regular complete blood count to check for clinically significant pancytopenia or thrombocytopenia.
Bautista-Quach
Marnelli A
MA
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, CA 92354, USA.
Liao
Yu-Min
YM
Hsueh
Chung-Tsen
CT
D000740:Anemia / Q000150:complications / Q000188:drug therapy*; D002998:Clonazepam / Q000009:adverse effects*; D005260:Female; D018757:GABA Modulators / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D010198:Pancytopenia / Q000139:chemically induced* / Q000175:diagnosis; D016896:Treatment Outcome
D018757:GABA Modulators; D002998:Clonazepam