title: Assessment of oxygen transport and utilization in dogs with naturally occurring sepsis.
abstract: OBJECTIVE
  To compare cardiac index (CI), oxygen delivery index (D(O(2))I), oxygen extraction ratio (O(2)ER), oxygen consumption index (V(O(2))I), and systemic vascular resistance index (SVRI) in dogs with naturally occurring sepsis with published values for healthy dogs; compare those variables in dogs with sepsis that did or did not survive; and compare CI and D(O(2))I in dogs with sepsis with values in dogs with nonseptic systemic inflammatory response syndrome (nSIRS).
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  10 dogs with naturally occurring sepsis and 11 dogs with nSIRS.
  
  
  METHODS
  Over 24 hours, CI, D(O(2))I, O(2)ER, V(O(2))I, and SVRI were measured 4 and 5 times in dogs with sepsis and with nSIRS, respectively. The mean values of each variable in each group were compared over time and between groups; data for dogs with sepsis that did or did not survive were also compared.
  
  
  RESULTS
  Mean D(O(2))I was significantly decreased, and mean CI, O(2)ER, V(O(2))I, and SVRI were not significantly different in dogs with sepsis, compared with published values for healthy dogs. Mean CI and D(O(2))I in dogs with sepsis were significantly greater than values in dogs with nSIRS. Among dogs with sepsis that did or did not survive, values of CI, D(O(2)I), O(2)ER, V(O(2))I, and SVRI did not differ significantly.
  
  
  CONCLUSIONS
  Compared with values in healthy dogs, only D(O(2))I was significantly lower in dogs with sepsis. Values of CI and D(O(2))I were significantly higher in dogs with sepsis than in dogs with nSIRS, suggesting differing degrees of myocardial dysfunction between these groups.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA. amy.butler@cvm.osu.edu
authors.forename: Amy L
authors.initials: AL
authors.lastname: Butler
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Campbell
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D018805:Sepsis / Q000378:metabolism*
chemical_list: D010100:Oxygen