title: Setting risk-informed environmental standards for Bacillus anthracis spores.
abstract: In many cases, human health risk from biological agents is associated with aerosol exposures. Because air concentrations decline rapidly after a release, it may be necessary to use concentrations found in other environmental media to infer future or past aerosol exposures. This article presents an approach for linking environmental concentrations of Bacillus. anthracis (B. anthracis) spores on walls, floors, ventilation system filters, and in human nasal passages with human health risk from exposure to B. anthracis spores. This approach is then used to calculate example values of risk-informed concentration standards for both retrospective risk mitigation (e.g., prophylactic antibiotics) and prospective risk mitigation (e.g., environmental clean up and reoccupancy). A large number of assumptions are required to calculate these values, and the resulting values have large uncertainties associated with them. The values calculated here suggest that documenting compliance with risks in the range of 10(-4) to 10(-6) would be challenging for small diameter (respirable) spore particles. For less stringent risk targets and for releases of larger diameter particles (which are less respirable and hence less hazardous), environmental sampling would be more promising.
authors.affiliation: Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Hong
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Gurian
authors.forename: Nicholas F Dudley
authors.initials: NF
authors.lastname: Ward
mesh_terms: D000818:Animals; D000881:Anthrax / Q000188:drug therapy / Q000453:epidemiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D001408:Bacillus anthracis / Q000187:drug effects / Q000472:pathogenicity*; D004782:Environmental Health / Q000592:standards*; D006801:Humans; D011446:Prospective Studies; D011597:Psychomotor Performance; D018570:Risk Assessment; D040242:Risk Reduction Behavior; D013171:Spores, Bacterial / Q000472:pathogenicity / Q000502:physiology; D014186:Transportation / Q000592:standards
chemical_list: D000900:Anti-Bacterial Agents