title: Central mucoepidermoid carcinoma, a case report with molecular analysis of the TORC1/MAML2 gene fusion.
abstract: Mucoepidermoid carcinoma is the most common salivary gland malignancy. The majorities of these tumors arise in the parotid and minor salivary glands, but may rarely develop intraosseously. The latter is not uncommonly associated with diagnostic and management difficulties. We report an example of intraosseous mucoepidermoid carcinoma with positive TORC1/MAML2 gene fusion transcript and discuss the clinical implications.
authors.affiliation: Department of Pathology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Johar Town, Lahore, Pakistan. haseeb.a.khan@hotmail.com
authors.forename: Haseeb Ahmed
authors.initials: HA
authors.lastname: Khan
authors.forename: Asif
authors.initials: A
authors.lastname: Loya
authors.forename: Rafay
authors.initials: R
authors.lastname: Azhar
authors.forename: Nasir Ud
authors.initials: NU
authors.lastname: Din
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
mesh_terms: D018277:Carcinoma, Mucoepidermoid / Q000000981:diagnostic imaging / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D050939:Gene Fusion; D006801:Humans; D007573:Jaw Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: C500984:CRTC1 protein, human; D004268:DNA-Binding Proteins; C471297:MAML2 protein, human; D009687:Nuclear Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors