title: Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer.
abstract: OBJECTIVE
  The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer.
  
  
  METHODS
  ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens.
  
  
  METHODS
  Formalin-fixed paraffin-embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53. Immunoreactivity was scored using a 0 to +3 scale in which staining was either (0) negative, (+1) spotty, (+2) weakly positive, or (+3) strongly positive.
  
  
  RESULTS
  ER was expressed in 8 of 47 tumors while PR was expressed in 4 of 47 tumors. p53 aberrations were demonstrated in 26 of 47 tumors. Tumors showed varying degrees of immunopositivity ranging from 0 to +3.
  
  
  CONCLUSIONS
  These studies suggest that p53 aberrations may be involved in ACC tumor progression and that ER and PR may play a role in ACC development.
authors.affiliation: Department of Otolaryngology, Stanford University, School of Medicine, 801 Welch Road, Stanford, CA 94305, USA. jebarrera@yahoo.com
authors.forename: Jose E
authors.initials: JE
authors.lastname: Barrera
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Shroyer
authors.forename: Sherif
authors.initials: S
authors.lastname: Said
authors.forename: George
authors.initials: G
authors.lastname: Hoernig
authors.forename: Raymond
authors.initials: R
authors.lastname: Melrose
authors.forename: Paul D
authors.initials: PD
authors.lastname: Freedman
authors.forename: Tanya A
authors.initials: TA
authors.lastname: Wright
authors.forename: Robert O
authors.initials: RO
authors.lastname: Greer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D016158:Genes, p53 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone