REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
Is oxytocin the hormone of happiness? Probably not. However, this small nine amino acid peptide is involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterus contraction, milk ejection, maternal behavior, osteoporosis, diabetes, cancer, social bonding, and stress, which makes oxytocin and its receptor potential candidates as targets for drug therapy. In this review, we address the issues of drug design and specificity and focus our discussion on recent findings on oxytocin and its heterotrimeric G protein-coupled receptor OTR. In this regard, we will highlight the following topics: (i) the role of oxytocin in behavior and affectivity, (ii) the relationship between oxytocin and stress with emphasis on the hypothalamo-pituitary-adrenal axis, (iii) the involvement of oxytocin in pain regulation and nociception, (iv) the specific action mechanisms of oxytocin on intracellular Ca²(+) in the hypothalamo neurohypophysial system (HNS) cell bodies, (v) newly generated transgenic rats tagged by a visible fluorescent protein to study the physiology of vasopressin and oxytocin, and (vi) the action of the neurohypophysial hormone outside the central nervous system, including the myometrium, heart and peripheral nervous system. As a short nine amino acid peptide, closely related to its partner peptide vasopressin, oxytocin appears to be ideal for the design of agonists and antagonists of its receptor. In addition, not only the hormone itself and its binding to OTR, but also its synthesis, storage and release can be endogenously and exogenously regulated to counteract pathophysiological states. Understanding the fundamental physiopharmacology of the effects of oxytocin is an important and necessary approach for developing a potential pharmacotherapy.
Viero
Cedric
C
Department of Cardiology, Wales Heart Research Institute, Cardiff University, UK.
Shibuya
Izumi
I
Kitamura
Naoki
N
Verkhratsky
Alexei
A
Fujihara
Hiroaki
H
Katoh
Akiko
A
Ueta
Yoichi
Y
Zingg
Hans H
HH
Chvatal
Alexandr
A
Sykova
Eva
E
Dayanithi
Govindan
G
D000339:Affect / Q000502:physiology; D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D009369:Neoplasms / Q000188:drug therapy; D010003:Osteoarthritis / Q000188:drug therapy; D010121:Oxytocin / Q000378:metabolism*; D018045:Receptors, Oxytocin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D012919:Social Behavior
D000700:Analgesics; D018045:Receptors, Oxytocin; D010121:Oxytocin