title: The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest.
abstract: BACKGROUND
  Currently, few data exist on the association between post-cardiac arrest hemodynamic function and outcome. In this explorative, retrospective analysis, the association between hemodynamic variables during the first 24 h after intensive care unit admission and functional outcome at day 28 was evaluated in 153 normothermic comatose patients following a cardiac arrest.
  
  
  METHODS
  Medical records of a multidisciplinary intensive care unit were reviewed for comatose patients (Glasgow Coma Scale < or = 9) admitted to the intensive care unit after successful resuscitation from an in- or an out-of-hospital cardiac arrest. The hourly variable time integral of hemodynamic variables during the first 24 h after admission was calculated. At day 28, outcome was assessed as favorable or adverse based on a Cerebral Performance Category of 1-2 and 3-5, respectively. Bi- and multivariate regression models adjusted for relevant confounding variables were used to evaluate the association between hemodynamic variables and functional outcome.
  
  
  RESULTS
  One hundred and fifty-three normothermic comatose patients were admitted after a cardiac arrest, of whom 64 (42%) experienced a favorable outcome. Neither in the adjusted bivariate models (r(2), 0.61-0.78) nor in the adjusted multivariate model (r(2), 0.62-0.73) was the hourly variable time integral of any hemodynamic variable during the first 24 h after intensive care unit admission associated with functional patient outcome at day 28 in all patients as well as in patients after an in- or an out-of-hospital cardiac arrest.
  
  
  CONCLUSIONS
  Commonly measured hemodynamic variables during the first 24 h following intensive care unit admission due to a cardiac arrest do not appear to be associated with the functional outcome at day 28.
authors.affiliation: Department of Intensive Care Medicine, Inselspital, Medical University of Bern, Bern, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Torgersen
authors.forename: C A
authors.initials: CA
authors.lastname: Schmittinger
authors.forename: J
authors.initials: J
authors.lastname: Takala
authors.forename: S M
authors.initials: SM
authors.lastname: Jakob
authors.forename: M W
authors.initials: MW
authors.lastname: Dünser
mesh_terms: D000368:Aged; D016887:Cardiopulmonary Resuscitation; D003128:Coma / Q000209:etiology* / Q000503:physiopathology*; D003422:Critical Care; D003627:Data Interpretation, Statistical; D023381:Endpoint Determination; D005260:Female; D015600:Glasgow Coma Scale; D006323:Heart Arrest / Q000150:complications* / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome