title: Imaging port wine stains by fiber optical coherence tomography.
abstract: We develop a fiber optical coherence tomography (OCT) system in the clinical utility of imaging port wine stains (PWS). We use our OCT system on 41 patients with PWS to document the difference between PWS skin and contralateral normal skin. The system, which operates at 4 frames with axial and transverse resolutions of 10 and 9 mum, respectively, in the skin tissue, can clearly distinguish the dilated dermal blood vessels from normal tissue. We present OCT images of patients with PWS and normal human skin. We obtain the structural parameters, including epidermal thickness and diameter and depth of dilated blood vessels. We demonstrate that OCT may be a useful tool for the noninvasive imaging of PWS. It may help determine the photosensitizer dose and laser parameters in photodynamic therapy for treating port wine stains.
authors.affiliation: Beijing Institute of Technology, Department of Optoelectronics, Beijing 100081, China.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Jin
authors.initials: J
authors.lastname: Guo
authors.forename: Tingmei
authors.initials: T
authors.lastname: Shen
authors.forename: Tianshi
authors.initials: T
authors.lastname: Wang
authors.forename: Naiyan
authors.initials: N
authors.lastname: Huang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Haixia
authors.initials: H
authors.lastname: Qiu
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.forename: Xunbin
authors.initials: X
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D019339:Port-Wine Stain / Q000473:pathology* / Q000628:therapy; D041623:Tomography, Optical Coherence / Q000379:methods*