title: Multivitamin-mineral and vitamins (E + C) supplementation modulate chronic unpredictable stress-induced oxidative damage in brain and heart of mice.
abstract: Brain is a target of stress along with the immune, metabolic, and cardiovascular systems of the body. In the present work, the preventive roles of a multivitamin-mineral supplement and vitamins (E + C) in chronic unpredictable stress (CUS)-induced oxidative damage were studied in the brain and heart of Swiss albino mice. Thirty-two mice were randomized to one of the following groups: control + vehicle, CUS + vehicle, CUS + multivitamin-mineral, and CUS + vitamins (E + C). CUS was applied for 4 weeks, and multivitamin-mineral and vitamins (E + C) were administered orally for the same period. CUS led to a negative impact on all the biochemical parameters analyzed. Elevation in malondialdehyde and reduction in glutathione levels were found. The activities of superoxide dismutase, catalase, glutathione S-transferase, and glutathione reductase were decreased. Treatment with multivitamin-mineral and vitamins (E + C) brought these parameters to near normal levels. Multivitamin-mineral was found more restitutive than combined vitamins (E + C) doses. The present study hypothesizes that supplementation with a multivitamin-mineral may prove more effective than vitamin treatment alone in the alleviation of oxidative damage in brain and heart during periods of chronic stress.
authors.affiliation: Department of Biochemistry, Faculty of Life Sciences, A. M. University, Aligarh, 202002 Uttar Pradesh, India.
authors.forename: Shirin
authors.initials: S
authors.lastname: Hasan
authors.forename: Nayeem
authors.initials: N
authors.lastname: Bilal
authors.forename: Shoa
authors.initials: S
authors.lastname: Naqvi
authors.forename: Ghulam Md
authors.initials: GM
authors.lastname: Ashraf
authors.forename: Nida
authors.initials: N
authors.lastname: Suhail
authors.forename: Sadhana
authors.initials: S
authors.lastname: Sharma
authors.forename: Naheed
authors.initials: N
authors.lastname: Banu
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D019587:Dietary Supplements; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000494:pharmacology; D051379:Mice; D008903:Minerals / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D008903:Minerals; D014815:Vitamins; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D001205:Ascorbic Acid