title: Protective role of three vegetable peels in alloxan induced diabetes mellitus in male mice.
abstract: The hitherto unknown glucose regulating role of three vegetable peels from cucurbitaceae family was evaluated. In a preliminary study, effects of ethanolic extracts of Cucurbita pepo, Cucumis sativus and Praecitrullus fistulosus peels were studied at 250 and 500 mg kg(-1) d(-1) for 15 days in the alterations in serum glucose and in hepatic lipid peroxidation (LPO) in male mice. In the pilot experiment, the effective and safe concentration of each peel was administered (p.o.) for 10 consecutive days and then on 11th and 12th days alloxan was administered along with peel extracts. The treatment was continued up to 15th day. At the end, alterations in serum glucose, insulin, triiodothyronine, thyroxine, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein, hepatic lipid peroxidation, superoxide dismutase and catalase were studied. All the three peel extracts nearly reversed most of these changes induced by alloxan suggesting their possible role in ameliorating diabetes mellitus and related changes in serum lipids. However, Cucurbita pepo peel was found to be the most effective. Total polyphenols, flavonoids and ascorbic acid contents of the test peels were also estimated, which appear to be associated with the observed antidiabetic and antioxidative potentials.
authors.affiliation: Endocrine Research Unit, School of Life Sciences,Takshashila Campus, Devi Ahilya Vishwavidhyalaya, Khandwa Road, Indore, MP, India. yamini.dixit@gmail.com
authors.forename: Yamini
authors.initials: Y
authors.lastname: Dixit
authors.forename: Anand
authors.initials: A
authors.lastname: Kar
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D019662:Cucurbitaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit; D007004:Hypoglycemic Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010636:Phenols / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols; D013482:Superoxide Dismutase / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014675:Vegetables; D014815:Vitamins / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D005419:Flavonoids; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D014815:Vitamins; D014284:Triiodothyronine; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid; D013974:Thyroxine