Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface.
Cell surface of leishmaniasis causal agent, a parasitic member of Protozoa of Leishmania genus, is covered by thick glycocalix consisting of various phosphatidylinositol-anchored molecules. This review deals with the structure and biosynthesis of the main phosphoglycans and glycoproteins of Leishmania cell surface, many of which incorporate the rare natural D-arabinopyranose, and the problem concerning the involvement of these molecules in support of Leishmania survival during their intricate life cycle is discussed.
Novozhilova
N M
NM
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. nnovogilov@gmail.com
Bovin
N V
NV
D001089:Arabinose / Q000737:chemistry; D006001:Glycoconjugates / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology; D006017:Glycolipids / Q000737:chemistry / Q000378:metabolism; D006028:Glycosphingolipids / Q000096:biosynthesis / Q000737:chemistry; D007891:Leishmania / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000737:chemistry; D008666:Metalloendopeptidases / Q000737:chemistry / Q000378:metabolism; D011509:Proteoglycans / Q000096:biosynthesis / Q000737:chemistry; D015800:Protozoan Proteins / Q000096:biosynthesis / Q000737:chemistry
D006001:Glycoconjugates; D006017:Glycolipids; D006028:Glycosphingolipids; D008565:Membrane Proteins; C400527:Ppg1 protein, Leishmania; D011509:Proteoglycans; D015800:Protozoan Proteins; C008290:lipophosphonoglycan; D001089:Arabinose; D008666:Metalloendopeptidases; C055146:glycoprotein gp63, Leishmania