Emerging links between CDK cell cycle regulators and Wnt signaling.
Wnt/beta-catenin signaling controls many aspects of cell behavior throughout development and in adults. One of its best-known and cancer-relevant functions is to stimulate cell proliferation. Recent work has implicated Wnt components in regulating mitotic events, suggesting that the cell cycle and Wnt signaling are directly linked. This concept has now been substantially strengthened with the finding that the mitotic CDK14/cyclin Y complex promotes Wnt signaling through phosphorylation of the LRP6 co-receptor, a key regulatory nexus in the Wnt/beta-catenin pathway. Thus, an unexpectedly tight collaboration between the mitotic cell cycle machinery and Wnt signaling is emerging, suggesting that this pathway might orchestrate mitotic processes.
Davidson
Gary
G
Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics, H. v. Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany. gary.davidson@kit.edu
Niehrs
Christof
C
D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism; D006801:Humans; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008938:Mitosis; D011973:Receptors, LDL / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
D016213:Cyclins; C555475:LRP6 protein, human; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D011973:Receptors, LDL; D051153:Wnt Proteins; D018844:Cyclin-Dependent Kinases