title: Wireless capsule endoscopy and proximal small bowel lesions in Crohn's disease.
abstract: OBJECTIVE
  To investigate the prevalence of proximal small bowel (SB) lesions detected by wireless capsule endoscopy (WCE) in Crohn's disease (CD).
  
  
  METHODS
  WCE was performed in 64 patients: 32 with CD of the distal ileum, and 32 controls with iron-deficiency anemia (IDA) or diarrhea. WCE was performed using the Given SB-WCE, followed by small intestine contrast ultrasonography (SICUS). Findings compatible with CD by using WCE included erosions, aphthoid or deep ulcers, and strictures/stenosis.
  
  
  RESULTS
  WCE detected proximal SB lesions in 16/32 (50%) patients (14 aphthoid ulcers, 2 deep ulcers, one stricture), which appeared not to be related to clinical parameters [epigastric pain, age, smoking, non-steroidal anti-inflammatory drugs (NSAIDs), IDA]. Among patients with proximal SB lesions, 6 (37%) were smokers, 3 (19%) NSAID users, 3 (19%) had epigastric pain and 4 (25%) had IDA. SICUS detected proximal SB lesions in 3/32 patients (19%) also showing lesions with WCE. No correlations were observed between proximal SB lesions assessed by WCE or by SICUS (chi(2) = 1.5, P = 0.2).
  
  
  CONCLUSIONS
  The use of WCE allows the detection of previously unknown upper SB lesions in a high proportion of patients with a previous diagnosis of CD involving the distal ileum.
authors.affiliation: GI Unit, Department of Internal Medicine, University Tor Vergata, Rome 00133, Italy.
authors.forename: Carmelina
authors.initials: C
authors.lastname: Petruzziello
authors.forename: Sara
authors.initials: S
authors.lastname: Onali
authors.forename: Emma
authors.initials: E
authors.lastname: Calabrese
authors.forename: Francesca
authors.initials: F
authors.lastname: Zorzi
authors.forename: Marta
authors.initials: M
authors.lastname: Ascolani
authors.forename: Giovanna
authors.initials: G
authors.lastname: Condino
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Lolli
authors.forename: Paola
authors.initials: P
authors.lastname: Naccarato
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
authors.forename: Livia
authors.initials: L
authors.lastname: Biancone
mesh_terms: D000328:Adult; D000368:Aged; D053704:Capsule Endoscopy; D016022:Case-Control Studies; D003287:Contrast Media; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000473:pathology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014456:Ulcer / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D003287:Contrast Media