title: Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy.
abstract: Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.
authors.affiliation: Department of Medicine, Internal Medicine 3, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy. drbalbim@yahoo.it
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Balbi
authors.forename: Valter
authors.initials: V
authors.lastname: Donadon
authors.forename: Michela
authors.initials: M
authors.lastname: Ghersetti
authors.forename: Silvia
authors.initials: S
authors.lastname: Grazioli
authors.forename: Giovanni Della
authors.initials: GD
authors.lastname: Valentina
authors.forename: Rita
authors.initials: R
authors.lastname: Gardenal
authors.forename: Maria Dal
authors.initials: MD
authors.lastname: Mas
authors.forename: Pietro
authors.initials: P
authors.lastname: Casarin
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zanette
authors.forename: Cesare
authors.initials: C
authors.lastname: Miranda
authors.forename: Paolo
authors.initials: P
authors.lastname: Cimarosti
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007558:Italy; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000453:epidemiology; D008113:Liver Neoplasms / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence