title: The LAT story: a tale of cooperativity, coordination, and choreography.
abstract: The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.
authors.affiliation: LCMB/CCR/NCI/NIH, Bethesda, Maryland 20892-4256, USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Balagopalan
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Coussens
authors.forename: Eilon
authors.initials: E
authors.lastname: Sherman
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Samelson
authors.forename: Connie L
authors.initials: CL
authors.lastname: Sommers
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D019070:Cell Lineage; D003001:Cloning, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D008967:Molecular Biology / Q000379:methods; D009154:Mutation; D010169:Palmitic Acids / Q000737:chemistry; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C110810:LAT protein, human; C491734:Lat protein, mouse; D008565:Membrane Proteins; D010169:Palmitic Acids; D010750:Phosphoproteins