title: Small peptide nanofibers as the matrices of molecular hydrogels for mimicking enzymes and enhancing the activity of enzymes.
abstract: Enzymes, together with the process of self-assembly, constitute necessary components of the foundation of life on the nanometre scale. The exceedingly high efficiency and selectivity exhibited by enzymes for catalyzing biotransformations naturally lead to the exploration of enzyme mimics and the applications of enzymes in industrial biotransformations. While the mimicking of enzymes aims to preserve the essence of enzymes in a simpler system than proteins, industrial biotransformations demand high activity and stability of enzymes. Recent research suggests that small peptide-based nanofibers in the form of molecular hydrogels can provide a general platform to achieve both important goals. This tutorial review will introduce the recent progress of these research activities on small peptide-based nanomaterials for catalysis and hopes to provide a starting point for further explorations that ultimately may lead to practical applications of enzymes and enzyme mimics for addressing important societal problems in energy, environment, and health.
authors.affiliation: Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.forename: Qigang
authors.initials: Q
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D000818:Animals; D032701:Biomimetics; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004798:Enzymes; D020100:Hydrogels; D010446:Peptide Fragments