title: Comparative analysis of pharmaceuticals and dietary supplements containing extracts from the leaves of Ginkgo biloba L.
abstract: Abstract: Chromatography (TLC and HPLC) tests were performed of 11 preparations containing dry extract of Ginkgo biloba leaves: three pharmaceuticals (preparations 1, 3 and 5) and eight dietary supplements (preparations 2, 4, 6-11), and dry extract of Ginkgo biloba leaves (preparation 12) as a standard certified for compliance with Eur. Ph. 6.1. and FP VIII (1, 2). Preparations registered in Poland as pharmaceuticals contained the major active ingredients (flavonoids and terpene lactones) in amount declared by their producers (and consistent with pharmacopoeial requirements) and acceptable level of potentially toxic ginkgolic acids (below 5 ppm). The concentration of active compounds in dietary supplements was varied. Some of them satisfied applicable quality criteria (mainly preparation 8), however, the majority had reduced levels of therapeutic compounds (4, 6, 7, 11) and increased concentration of ginkgolic acids (4, 9, 10, 11).
authors.affiliation: Department of Pharmacognosy, Poznań University of Medical Sciences, Swiecickiego 4, 60-781 Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Gawron-Gzella
authors.forename: Paulina
authors.initials: P
authors.lastname: Marek
authors.forename: Justyna
authors.initials: J
authors.lastname: Chanaj
authors.forename: Irena
authors.initials: I
authors.lastname: Matławska
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D019587:Dietary Supplements / Q000032:analysis*; D005419:Flavonoids / Q000032:analysis; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides / Q000032:analysis; D006868:Hydrolysis; D007783:Lactones / Q000032:analysis; D010936:Plant Extracts / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry; D013729:Terpenes / Q000032:analysis
chemical_list: D005419:Flavonoids; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D013729:Terpenes