Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of Ardisia cornudentata.
Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4- 6, 9- 15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R (V) IN VITRO, with MIC values of 2.5-60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone ( 8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC (50) values of 2.3, 2.5 µg/mL).
Chang
Chun-Po
CP
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chang
Hsun-Shuo
HS
Peng
Chien-Fang
CF
Lee
Shiow-Ju
SJ
Chen
Ih-Sheng
IS
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D005591:Chemical Fractionation; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000995:Antitubercular Agents; D016227:Benzoquinones; D012118:Resorcinols; C031389:resorcinol