A sympathetic view on free radicals in diabetes.
Neuropathies are severe complications of diabetes. In this issue of Neuron, Campanucci et al. report that hyperglycemia-induced elevation of reactive oxygen species impairs synaptic transmission of sympathetic neurons leading to diabetes-induced dysautonomias. These observations provide new insights into the etiology of diabetic complications and suggest potential novel therapeutic approaches for neuropathies.
Diano
Sabrina
S
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA. sabrina.diano@yale.edu
Horvath
Tamas L
TL