Thermo-responsive Mn-Zn ferrite/poly(N,N'-isopropyl acrylamide-co-N-hydroxymethylacrylamide) core/shell nanocomposites for drug-delivery systems.
A kind of thermo-sensitive core/shell nanoparticles (Mn-Zn ferrite/poly(N,N'-isopropylacrylamide-co-N-hydroxymethylacrylamide)) has been designed in this work. By using the surface initiated method, a thermoresponsive co-polymer composed of N,N'-isopropylacrylamide (NIPAAm) and N-hydroxymethylacrylamide (HMAAm) was grafted from ferrite core. The nanoparticles obtained were characterized by FT-IR, XRD, TGA, HRTEM and DLS. The HRTEM observation showed a clear contrast between an ordered crystalline core and a light amorphous polymeric coating. DLS results confirmed the temperature sensitivity of the nanoparticles. In vitro hyperthermia showed well-controlled self-heating properties, indicating that the nanoparticles could potentially be used as an anticancer drug carrier in the biomedical field.
Yang
Cao
C
Institute of Nano and Biopolymeric Materials, School of Materials Science and Engineering, Tongji University, 200092 Shanghai, P. R. China.
Jie
Ren
R
Jianbo
Li
L
Yan
Liu
L
D000180:Acrylic Resins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006358:Hot Temperature; D008345:Manganese / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry; D058105:Polymerization; D013696:Temperature; D015032:Zinc / Q000737:chemistry*
D000180:Acrylic Resins; D004337:Drug Carriers; D005290:Ferric Compounds; D008689:Methacrylates; D017646:Organosilicon Compounds; C483328:poly(N-isopropylacrylamide-co-N-hydroxylmethylacrylamide); C001215:ferrite; D008345:Manganese; D015032:Zinc; C505504:3-(trimethoxysilyl)propyl methacrylate