Well-differentiated endocrine cell carcinoma of ileum treated by laparoscopy-assisted surgery--a case report.
A 72-year-old woman presented at our hospital with a 1-year history of intermittent right lower abdominal pain. Colonoscopic examination revealed a submucosal tumor with a pitted surface in the terminal ileum. Histopathological diagnosis of the carcinoid tumor was made following biopsy. Blood serotonin and urine 5-hydroxy-indoleacetic acid levels were normal, and carcinoid syndrome was not detected. Enhanced abdominal computed tomography scan and 18F-fluorodeoxyglucose positron emission tomography failed to detect multiple lesions, lymph node swelling or distant metastasis. Laparoscopy-assisted ileocecal resection with lymph node dissection was performed. The resected specimen showed a submucosal tumor with a pitted surface 11 x 11 mm in size, located at the terminal ileum. Histopathological examination revealed a well-differentiated endocrine cell carcinoma with an invasion depth to the muscularis propria. Immunohistochemical analysis showed the tumor cells to be chromogranin A and CD56-positive. The patient had no sign of recurrence for 16 months.
Sasada
Shinsuke
S
Department of Surgery, Hiroshima City Hospital, 7-33 Moto-machi, Naka-ku, Hiroshima 730-8518, Japan. sasachy@yahoo.co.jp
Ojima
Yasutomo
Y
Nishizaki
Masahiko
M
Harano
Masao
M
Matsukawa
Hiroyoshi
H
Aoki
Hideki
H
Shiozaki
Shigehiro
S
Ohno
Satoshi
S
Ninomiya
Motoki
M
Matsuura
Hiroo
H
Takakura
Norihisa
N
D000368:Aged; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D004701:Endocrine Gland Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology*; D010535:Laparoscopy; D014057:Tomography, X-Ray Computed