Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test.
Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculated that caramiphen, another centrally acting antitussive, has an antidepressant-like effect. That effect of caramiphen was studied in rats using the forced swimming test. Caramiphen at 20 and 40mg/kg i.p. significantly reduced immobility. At 40mg/kg i.p., it increased climbing behavior. Even at 40mg/kg, this drug had no effect on locomotor activity. Results suggest that a centrally acting antitussive possessing inhibition of GIRK channels has an antidepressant-like effect.
Kawaura
Kazuaki
K
Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
Miki
Risa
R
Shima
Eriko
E
Honda
Sokichi
S
Soeda
Fumio
F
Shirasaki
Tetsuya
T
Takahama
Kazuo
K
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000996:Antitussive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003517:Cyclopentanes / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy*; D013550:Swimming
D000928:Antidepressive Agents; D000996:Antitussive Agents; D003517:Cyclopentanes; C004519:caramiphen