[Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues].
OBJECTIVE
To determine the role of fragile histidine triad (FHIT) and MDM2 in carcinogenesis of oral submucous fibrosis (OSF).


METHODS
The expression of FHIT and MDM2 was examined by immunohistochemical S-P method in 44 OSF cases, 15 canceration tissues of OSF, and 10 normal oral mucosa tissues.


RESULTS
The expression of FHIT was positive in the normal oral mucosa epithelium. The positive expression of FHIT decreased in the OSF and canceration tissues of the OSF.The rate of FHIT positive expression was significantly lower in canceration tissues of OSF than that of the OSF (P < 0.05). The expression of MDM2 was negative in normal oral mucosa epithelium. The positive expression of MDM2 increased in the OSF and canceration tissues of the OSF, and the rate of MDM2 positive expression was significantly higher in the canceration tissues of OSF than that of the OSF (P < 0.05).


CONCLUSIONS
The loss of FHIT and over-expression of MDM2 may play an important role in the carcinogenesis of OSF.
Yin
Xiaomin
X
Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410078, China.
Wen
Chunyan
C
Han
Yuling
Y
Gao
Yijun
Y
Tang
Zhangui
Z
D017766:Acid Anhydride Hydrolases / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009914:Oral Submucous Fibrosis / Q000378:metabolism*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics / Q000378:metabolism*; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D051736:Proto-Oncogene Proteins c-mdm2; D000099170:Bis(5'-adenosyl)triphosphatase; C497206:MDM2 protein, human