title: Proangiogenic cytokines vascular-endothelial growth factor and basic fibroblst growth factor in childhood lymphadenopathy.
abstract: Increased angiogenesis is observed both in the inflammatory and in the neoplasmatic tissue. The aim of the study was to assess the diagnostic significance of serum concentration of vascular-endothelial growth factor (sVEGF) and basic fibroblast growth factor (sbFGF) in the various forms of lymphadenopathy in children. Ninety-four children with lymphadenopathy were studied: group A, 52 patients with lymphadenitis; group B, 42 patients with lymphomas. Group B was divided into subgroups: B(P), children with lymphomas in peripheral lymph nodes and B(M), children with lymphomas in peripheral lymph nodes and mediastinal tumor. The healthy control group was 20 children. Using enzyme-linked immunosorbent assays the authors quantified VEGF and bFGF in serum of healthy children and of children with lymphadenopathy. The sVEGF in group A was significantly higher than controls (313.8 versus 44.6 pg/mL; P <.05) and in group B was 633.4 pg/mL and was significantly higher than controls (P <.0001). The sVEGF and bFGF in group A versus subgroup B(P) were significantly lower (P(VEGF) <.05, P(bFGF) <.05), and sVEGF in subgroup B(P) versus B(M) was significantly lower (P <.05). These results show that the evaluation of serum VEGF concentration might be useful as noninvasive diagnosis of some chronic peripheral lymphadenopathies in children.
authors.affiliation: Department of Pediatric Oncology, Hematology and Chemotherapy, Medical University of Silesia, Upper-Silesia Center of Children's Health Care, Katowice, Poland. a.mizia@wp.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mizia-Malarz
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sobol
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Musioł
authors.forename: Joanna
authors.initials: J
authors.lastname: Janowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Zahorska-Markiewicz
authors.forename: Halina
authors.initials: H
authors.lastname: Wos
mesh_terms: D000293:Adolescent; D042501:Angiogenic Proteins / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D008199:Lymphadenitis / Q000097:blood / Q000175:diagnosis; D008206:Lymphatic Diseases / Q000097:blood* / Q000175:diagnosis*; D008223:Lymphoma / Q000097:blood / Q000175:diagnosis; D008297:Male; D009389:Neovascularization, Pathologic / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D042501:Angiogenic Proteins; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2