Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.
We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.
Ahmadi
Neda
N
Department of Otolaryngology Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA.
Goldman
Radoslav
R
Seillier-Moiseiwitsch
Françoise
F
Noone
Anne-Michelle
AM
Kosti
Ourania
O
Davidson
Bruce J
BJ