title: Results of the oral egg-challenge test performed on two different groups of children. One group with a history, suggestive of allergic reaction with egg intake and the other group sensitised to hen's egg without previous egg intake.
abstract: BACKGROUND
  Egg allergy is an adverse immune-system reaction of an IgE-mediated type, which can happen in children after egg intake and several times after their first egg intake.
  
  
  OBJECTIVE
  Compare the results of the oral egg-challenge test in two groups of egg-sensitised children, with and without prior intake.
  
  
  METHODS
  Retrospective study of two egg-sensitised groups (72 subjects). Group 1: 22 children without prior egg-intake. Group 2: 50 children with a clinical history of adverse reactions after egg intake. Skin prick tests, egg-white specific IgE (sIgE) and yolk specific IgE, were performed on all children. The oral egg-challenge tests were performed after a period of egg-avoidance diet and when egg-white specific IgE levels were lower than 1.5K U/L.
  
  
  RESULTS
  31.8% of the children in Group 1 did not tolerate egg-intake whereas 38% of the children in Group 2 did not tolerate egg-intake. Egg-avoidance periods lasted 19.5 and 18 months, respectively. Egg-white specific IgE levels went down in both groups after an egg-avoidance diet. No statistically significant differences were found between the groups and the positivity of oral egg-challenge test.
  
  
  CONCLUSIONS
  No statistically significant differences were found in the behaviour of the two groups studied. Given the high risk of adverse reactions, it was recommended that any egg-introduction tests were to be performed in a hospital environment on the children who were sensitised to hen's egg (including children without prior egg intake).
authors.affiliation: The Maternity and Children's Vall d'Hebron Hospital, Allergy Department, Barcelona, Spain. tatiana.fadeeeva@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Fadeeva
authors.forename: J L Eseverri
authors.initials: JL
authors.lastname: Asin
authors.forename: M Labrador
authors.initials: ML
authors.lastname: Horrillo
authors.forename: T Garriga
authors.initials: TG
authors.lastname: Baraut
authors.forename: R F Ocaña
authors.initials: RF
authors.lastname: Vela
authors.forename: S L Romero
authors.initials: SL
authors.lastname: Conde
authors.forename: O Esteso
authors.initials: OE
authors.lastname: Hontoria
authors.forename: C Blasco
authors.initials: CB
authors.lastname: Valero
authors.forename: A M Marin
authors.initials: AM
authors.lastname: Molina
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004435:Eating; D021181:Egg Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D004531:Eggs / Q000009:adverse effects; D005260:Female; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D009113:Muramidase / Q000276:immunology*; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; C421864:hen egg lysozyme; D009113:Muramidase