Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A.
Eighteen schizandrin A derivatives, possessing an acyl group at 7-OH and/or halogen(s) at C-4 and C-11, were designed and synthesized for evaluation of their in vitro ability to inhibit multidrug resistance (MDR). They exhibit weak ability to restore the intracellular Rhodamine 123 in human hepatocarcinoma MDR cell lines Bel7402 and HCT8 relative to the reference drug verapamil.
Liang
Xiao-Xia
XX
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China.
Liu
Geng-Tao
GT
Chen
Qiao-Hong
QH
Sun
Hua
H
Chen
Dong-Lin
DL
Wang
Feng-Peng
FP
D034242:Cyclooctanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020112:Rhodamine 123 / Q000032:analysis; D032141:Schisandra / Q000737:chemistry; D013329:Structure-Activity Relationship
D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; D020112:Rhodamine 123; C034734:schizandrin A