title: Quantifying the role of natalizumab in health and economic outcomes in multiple sclerosis.
abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system defined by inflammation, demyelination, and axonal degeneration. MS progresses slowly and usually strikes at a fairly young age, causing both the direct and indirect costs of treating the disease to be very high. The direct costs to treat MS can average up to $30,000 per year; including indirect costs raises this to as high as $47,000. Natalizumab has proven to be able to reduce the signs of MS and has been associated with improvements in health-related quality-of-life measures; these effects have the potential to also reduce some of the economic burden of this debilitating disease. The significant clinical burden of MS can be quantified by cost and societal impact, important information to both payers and employers.
authors.affiliation: Hope Neurology, Knoxville, TN, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Brandes
authors.forename: Fadia T
authors.initials: FT
authors.lastname: Shaya
authors.forename: Michael W
authors.initials: MW
authors.lastname: Pill
mesh_terms: D000367:Age Factors; D000911:Antibodies, Monoclonal / Q000191:economics* / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D003365:Costs and Cost Analysis; D018450:Disease Progression; D006296:Health Services / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D007166:Immunosuppressive Agents / Q000191:economics / Q000627:therapeutic use; D039001:Integrin alpha Chains / Q000037:antagonists & inhibitors*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000191:economics*; D000069442:Natalizumab; D011788:Quality of Life; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; D039001:Integrin alpha Chains; D000069442:Natalizumab