BRCA1 16 years later: DNA damage-induced BRCA1 shuttling.
The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end-joining-mediated DNA repair following DNA damage will be reviewed, as well as the activation of apoptotic pathways. The control of these functions via DNA damage-induced BRCA1 shuttling will also be discussed, in particular BRCA1 shuttling induced by erlotinib and irradiation. Finally, the potential targeting of BRCA1 shuttling as a novel strategy to sensitize cells to DNA damage will be entertained.
Yang
Eddy S
ES
Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-5671, USA.
Xia
Fen
F
D021581:Active Transport, Cell Nucleus; D017209:Apoptosis; D019313:BRCA1 Protein / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D006801:Humans; D015398:Signal Transduction
D019313:BRCA1 Protein