[GammaH2AX-mediated repair of DNA damaged sperm in the zygote].
Male germ cells are particularly susceptible to DNA damage by genotoxic agents during spermiogenesis and spermatozoal maturation, and meanwhile lack an effective repair system to eliminate the lesions. Because the DNA damaged sperm still has fertilizability and developmental potentiality, damage repair may occur after fertilization, but its mechanism remains unknown. Histone H2AX phosphorylation (gammaH2AX) is reportedly involved in the repair of damaged sperm DNA after fertilization. This review aims to summarize the present knowledge on the mechanism of gammaH2AX-mediated repair of DNA damaged sperm in the zygote.
Liu
Wan-Min
WM
[Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China]
Liu
Rong-Ju
RJ
Li
Zhi-Ling
ZL
D004249:DNA Damage; D004260:DNA Repair; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D010766:Phosphorylation; D013094:Spermatozoa / Q000473:pathology*; D015053:Zygote
C468783:H2AX protein, human; D006657:Histones