title: Long-term follow-up study of clear cell papulosis.
abstract: BACKGROUND
  Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown.
  
  
  OBJECTIVE
  The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome.
  
  
  METHODS
  Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed.
  
  
  RESULTS
  With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density.
  
  
  CONCLUSIONS
  Retrospective nature of the study is a limitation.
  
  
  CONCLUSIONS
  No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Fang-Wen
authors.initials: FW
authors.lastname: Tseng
authors.forename: Tseng-Tong
authors.initials: TT
authors.lastname: Kuo
authors.forename: Pei-Hsuan
authors.initials: PH
authors.lastname: Lu
authors.forename: Heng-Leong
authors.initials: HL
authors.lastname: Chan
authors.forename: Ming-Jing
authors.initials: MJ
authors.lastname: Chan
authors.forename: Rosaline Chung-Yee
authors.initials: RC
authors.lastname: Hui
mesh_terms: D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017496:Hypopigmentation / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D018396:Mucin-1 / Q000378:metabolism; D010145:Paget Disease, Extramammary / Q000473:pathology; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D002272:Carcinoembryonic Antigen; D018396:Mucin-1