title: Effect of waterborne copper exposure on growth, hepatic enzymatic activities and histology in Synechogobius hasta.
abstract: The present study was conducted to determine growth, hepatic enzymatic activities and histology in Synechogobius hasta exposed to waterborne copper concentrations of 0 (control), 0.15 and 0.3 mg Cu/l, respectively, for 15 days, and explore whether waterborne copper exposure could induce the fatty liver syndrome for the fish species. Growth (WG and SGR) declined, but HSI increased in S. hasta with increasing waterborne copper levels (P<0.05). Waterborne copper exposure also significantly increased lipid content and reduced protein content in both whole body and liver, and increased copper accumulation in whole body and vertebrae. Copper exposure changed hepatic enzymatic activities (SOD, CAT, SDH, PK, LDH, LPL and HL) and increased hepatic lipid peroxidation level, impaired the histological structure of the gill and liver in S. hasta. Thus, our study demonstrated for the first time that waterborne Cu exposure could induce fatty liver syndrome in fish.
authors.affiliation: Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Luo
authors.forename: B X
authors.initials: BX
authors.lastname: Xiong
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhao
authors.forename: G F
authors.initials: GF
authors.lastname: Hu
authors.forename: G J
authors.initials: GJ
authors.lastname: Lv
mesh_terms: D000818:Animals; D003300:Copper / Q000633:toxicity*; D005880:Gills / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D010473:Perciformes / Q000254:growth & development*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D003300:Copper