title: Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings.
abstract: Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China. dt_zhang@yahoo.com.cn
authors.forename: Datong
authors.initials: D
authors.lastname: Zhang
authors.forename: Jiong
authors.initials: J
authors.lastname: Jia
authors.forename: Lijuan
authors.initials: L
authors.lastname: Meng
authors.forename: Weiren
authors.initials: W
authors.lastname: Xu
authors.forename: Lida
authors.initials: L
authors.lastname: Tang
authors.forename: Jianwu
authors.initials: J
authors.lastname: Wang
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009904:Optical Rotation; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044366:Transition Temperature
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D013386:Succinates; D000581:Amidohydrolases; C084507:peptide deformylase