[The interferon-induced and antiviral activities of dipeptides].
Five phosphodipeptides were synthesized; two of them (H-Lys-Ala(P) and H-Pro-Ala(P) had interferon-induced activity. These dipeptides at millimolar concentrations (10(-4)) and 10(-5) M) induced the synthesis of late (40-hour) interferon in human peripheral blood lymphocytes. The dipeptides H-Lys-Ala(P) and H-Pro-Ala(P) showed a protective antiviral activity in in vivo studies when singly intraperitoneally administered to mice 2 hours before inoculation with murine encephalomyocarditis virus.
Nosik
N N
NN
Lavrukhina
L A
LA
Kondrashina
N G
NG
Garaev
T M
TM
Shibnev
V A
VA
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018188:Cardiovirus Infections / Q000517:prevention & control; D002460:Cell Line; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004686:Encephalomyocarditis virus / Q000187:drug effects; D006801:Humans; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007372:Interferons / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010748:Phosphopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D004151:Dipeptides; D007369:Interferon Inducers; D010748:Phosphopeptides; D007372:Interferons