title: A prospective double blind study using oral versus vaginal misoprostol for labour induction.
abstract: This prospective double blind study was undertaken to compare the safety and efficacy of oral vs vaginal misoprostol in equivalent doses (50 microg) for induction of labour. A total of 128 term pregnancies with indication for induction of labour were allocated to two groups to receive 50 microg misoprostol orally or vaginally, every 4 h until adequate contractions were achieved or a maximum of 200 microg dose. Induction to delivery interval was significantly shorter in the vaginal group compared with the oral group (14.6 h vs 22.5 h; p < 0.001). There was no significant difference between the groups with respect to mode of delivery, neonatal outcome and maternal side-effects. However, the incidence of abnormal contractility pattern was more common in the vaginal group (10/68, 14.6%) as compared with the oral group (4/60, 6.6%) (p = 0.146).
authors.affiliation: Department of Obstetrics and Gynaecology, King George's Medical University (CSM Medical University), Lucknow, India. mehrotra.seema@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Mehrotra
authors.forename: U
authors.initials: U
authors.lastname: Singh
authors.forename: H P
authors.initials: HP
authors.lastname: Gupta
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D014590:Uterine Contraction / Q000187:drug effects*; D055815:Young Adult
chemical_list: D010120:Oxytocics; D016595:Misoprostol