[Pneumocystis jiroveci and cytomegalovirus pneumonia in patients with alcoholic hepatic cirrhosis].
We have described a fatal case of interstitial pneumonia with pleuritis in woman, 54 years old, suffered from end stage liver disease caused by ethanolic hepatic cirrhosis. Broncholavage microbiological culture was negative but biomolecular assays with polymerase chain reaction demonstred Pneumocystis jiroveci and Cytomegalovirus. She died despite aetiological therapy with cotrimoxazole and gancyclovir. Immunodeficiency of the delayed immune response, related to the severe liver disease and ethanol use, explains the occurrence of these opportunistic infections in ethanolic cirrhotic patients too.
Dodi
Ferdinando
F
U.O. Malattie Infettive, A.O.U. San Martino, Genova, Italy.
Centanaro
Monica
M
Campolucci
Andrea
A
Valente
Umberto
U
Pagano
Gabriella
G
D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis; D017809:Fatal Outcome; D005260:Female; D006530:Hepatorenal Syndrome / Q000209:etiology; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000276:immunology; D044342:Malnutrition / Q000150:complications; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology / Q000821:virology; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000150:complications* / Q000175:diagnosis; D011024:Pneumonia, Viral / Q000150:complications* / Q000175:diagnosis; D012128:Respiratory Distress Syndrome / Q000209:etiology