title: Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: the year in review.
abstract: The nervous system and cardiovascular system have long been known to interact. Only more recently, however, have the mechanisms driving this interaction become more clearly understood. Although many psychological disturbances, including depression and anxiety, are known to predict poor outcomes in patients with cardiovascular disease, other neurologic disturbances, such as migraine and stroke, have been connected to poor cardiovascular outcomes as well. Although these connections were traditionally thought to be due to shared risk factors, recent research has focused on pathophysiologic mechanisms underlying these interactions, including neuroendocrine dysregulation, genetic predisposition, and vascular dysfunction.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0277, USA. ki.park@medicine.ufl.edu
authors.forename: Ki E
authors.initials: KE
authors.lastname: Park
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Pepine
mesh_terms: D001792:Blood Platelets / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D003863:Depression / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000166:cytology / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008881:Migraine Disorders / Q000235:genetics; D017202:Myocardial Ischemia / Q000209:etiology / Q000235:genetics; D009422:Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012701:Serotonin / Q000009:adverse effects / Q000235:genetics / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013315:Stress, Psychological / Q000150:complications; D020521:Stroke / Q000235:genetics
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin