Dynamics of dendritic cell-T cell interactions: a role in T cell outcome.
Antigen-specific dendritic cells (DC)-T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC-T cell contacts during priming and tolerance induction. The mechanisms that favour DC-T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review.
Hugues
Stéphanie
S
Department of Pathology, University of Geneva Medical School, Geneva, Switzerland. Stephanie.hugues@unige.ch
D000818:Animals; D017951:Antigen Presentation; D002450:Cell Communication / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*