Reagent-controlled oxidative aromatization in iodocyclization: switchable access to dihydropyrazoles and pyrazoles.
Switchable access to dihydropyrazoles and pyrazoles has been developed from common hydrazides by reagent-controlled iodocyclization. Controlling the oxidative aromatization in iodocyclization for heterocycles is reported for the first time, and this methodology maximally utilizes the dual nature of iodine.
Okitsu
Takashi
T
Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Sato
Kana
K
Wada
Akimori
A
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007202:Indicators and Reagents; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D011720:Pyrazoles; D007455:Iodine