[Circulating cell-free serum DNA: significance as a new biomarker for urological malignancies].
The presence of circulating cell-free DNA was demonstrated already in the 1940s. Improved detection methods have led to increased knowledge on cell-free DNA, and recent studies showed that most cancer patients have increased levels of cell-free DNA. Measurement of cell-free DNA allowed sensitive and specific discrimination between cancer patients and those with non-malignant diseases.
Ellinger
J
J
Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Bonn, Deutschland. joerg.ellinger@ukb.uni-bonn.de
von Rücker
A
A
Bastian
P J
PJ
Müller
S C
SC
D014408:Biomarkers, Tumor / Q000097:blood*; D002474:Cell-Free System; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics*; D003950:Diagnostic Techniques, Urological; D006801:Humans; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000235:genetics*
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm