Regulation of acinar cell function in the pancreas.
OBJECTIVE
This review identifies and puts into context the recent articles which have advanced understanding of the functions of pancreatic acinar cells and the mechanisms by which these functions are regulated.


RESULTS
Receptors present on acinar cells, particularly those for cholecystokinin and secretin, have been better characterized as to the molecular nature of the ligand-receptor interaction. Other reports have described the potential regulation of acinar cells by GLP-1 and cannabinoids. Intracellular Ca2+ signaling remains at the center of stimulus secretion coupling and its regulation has been further defined. Recent studies have identified specific channels mediating Ca2+ release from intracellular stores and influx across the plasma membrane. Work downstream of intracellular mediators has focused on molecular mechanisms of exocytosis particularly involving small G proteins, SNARE proteins and chaperone molecules. In addition to secretion, recent studies have further defined the regulation of pancreatic growth both in adaptive regulation to diet and hormones in the regeneration that occurs after pancreatic damage. Lineage tracing has been used to show the contribution of different cell types. The importance of specific amino acids as signaling molecules to activate the mTOR pathway is being elucidated.


CONCLUSIONS
Understanding the mechanisms that regulate pancreatic acinar cell function is contributing to knowledge of normal pancreatic function and alterations in disease.
Williams
John A
JA
Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109-5622, USA. jawillms@umich.ed
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D046790:Pancreas, Exocrine / Q000166:cytology* / Q000502:physiology*; D012038:Regeneration; D015398:Signal Transduction
D002118:Calcium