Functional decline after incident wrist fractures--Study of Osteoporotic Fractures: prospective cohort study.
OBJECTIVE
To study the effect of an incident wrist fracture on functional status in women enrolled in the Study of Osteoporotic Fractures.


METHODS
Prospective cohort study.


METHODS
Baltimore, Minneapolis, Portland, and the Monongahela valley in Pennsylvania, USA PARTICIPANTS: 6107 women aged 65 years and older without previous wrist or hip fracture recruited from the community between September 1986 and October 1988.


METHODS
Clinically important functional decline, defined as a functional deterioration of 5 points in five activities of daily living each scored from 0 to 3 (equivalent to one standard deviation decrease in functional ability).


RESULTS
Over a mean follow-up of 7.6 years, 268 women had an incident wrist fracture and 41 (15%) of these developed clinically important functional decline. Compared with women without wrist fractures, those with incident wrist fractures had greater annual functional decline after adjustment for age, body mass index, and health status. Occurrence of a wrist fracture increased the odds of having a clinically important functional decline by 48% (odds ratio 1.48, 95% confidence interval 1.04 to 2.12), even after adjustment for age, body mass index, health status, baseline functional status, lifestyle factors, comorbidities, and neuromuscular function.


CONCLUSIONS
Wrist fractures contribute to clinically important functional decline in older women.
Edwards
Beatrice J
BJ
Bone Health and Osteoporosis Center, Division of Geriatrics, Feinberg School of Medicine, Northwestern University, 645 N Michigan, Chicago, IL 60611, USA. Bje168@northwestern.edu
Song
Jing
J
Dunlop
Dorothy D
DD
Fink
Howard A
HA
Cauley
Jane A
JA
D000368:Aged; D015519:Bone Density / Q000502:physiology; D005260:Female; D050723:Fractures, Bone / Q000503:physiopathology*; D005598:Fractures, Spontaneous / Q000503:physiopathology*; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D014954:Wrist Injuries / Q000503:physiopathology*