A chemical tool box defines mitotic and interphase roles for Mps1 kinase.
In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and mitotic inhibitors of Cdc20, and correction of faulty microtubule attachments.
Lan
Weijie
W
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Cleveland
Don W
DW
D000818:Animals; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020090:Chromosome Segregation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007399:Interphase / Q000187:drug effects / Q000502:physiology*; D018386:Kinetochores / Q000201:enzymology; D008870:Microtubules / Q000201:enzymology; D008938:Mitosis / Q000187:drug effects / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases
D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; D047428:Protein Kinase Inhibitors; C577488:CDC20 protein, human; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; C075840:TTK protein, human