[Utility of fecal markers of inflammation in the diagnostics of inflammatory bowel diseases].
Many reports from recent years indicate the important role of fecal markers of inflammation. These are proteins produced by neutrocytes, monocytes and hepatocytes. The concentration of these proteins increases in the process of inflammation. These parameters are very sensitive because changes in their levels particularly reflect inflammatory conditions in the intestines. In this study we discuss the role of measurements of proteins such as: alpha 1-antitrypsin, myeloperoxydase, lactoferrin, calprotectin, S100A12 protein and pyruvate kinase in stool. The largest number of studies indicating the usefulness in the diagnosis and monitoring the course of inflammatory bowel diseases concerns stool lactoferrin and calprotectin.
Borkowska
Anna
A
Katedra i Klinika Pediatrii, Gastroenterologii, Hepatologii i Zywienia Dzieci Gdański Uniwersytet Medyczny. andzia@amg.gda.pl
Liberek
Anna
A
Plata-Nazar
Katarzyna
K
Kamińiska
Barbara
B
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D005243:Feces / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D018836:Inflammation Mediators / Q000032:analysis*; D007781:Lactoferrin / Q000032:analysis; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis; D009195:Peroxidase / Q000032:analysis; D011770:Pyruvate Kinase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D015415:Biomarkers; D018836:Inflammation Mediators; D039841:Leukocyte L1 Antigen Complex; D009418:S100 Proteins; C110294:S100A1 protein; C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin; D009195:Peroxidase; D011770:Pyruvate Kinase; D007781:Lactoferrin