The modulatory effects of rostral ventromedial medulla on air-puff evoked microarousals in rats.
This study tested whether the duration of microarousals from sleep evoked by innocuous air-puff is affected by intra-RVM administration of neurotensin and bicuculline, pharmacological manipulations that affect on and off cell activity. Air-puff evoked microarousal duration was unaffected by 0.05ng neurotensin, but decreased by 502ng neurotensin, and 5 and 50ng bicuculline. These results suggest a putative role for off cells in protecting sleep from interruption by non-noxious stimuli.
Foo
H
H
Department of Neurobiology, University of Chicago, 947 East 58th Street, Chicago, IL 60637, United States. hfoo@bsd.uchicago.edu
Crabtree
Katherine
K
Mason
Peggy
P
D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D004569:Electroencephalography; D004576:Electromyography; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009496:Neurotensin / Q000494:pharmacology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep
D058787:GABA-A Receptor Antagonists; D009496:Neurotensin; D001640:Bicuculline