Circulating levels of inflammatory markers in intrauterine growth restriction.
We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B--probably reflecting brain and adipose tissue inflammation--in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation. Serum hs-CRP, PAI-1, and S100B levels were measured in 40 mothers, and their 20 AGA and 20 IUGR full-term fetuses and neonates on postnatal days 1 and 4. hs-CRP, PAI-1, and S100B levels did not differ at all time points between AGA and IUGR groups. We conclude that the lack of difference in hs-CRP, PAI-1 and S100B levels, between IUGR and AGA fetuses/neonates--despite the lower birth weight, reflecting reduced fat mass in the former--might indicate more intense adipose tissue and nervous system inflammation in IUGRs. However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g. preeclampsia), cannot be excluded.
Boutsikou
Theodora
T
Neonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, Greece.
Mastorakos
George
G
Kyriakakou
Marialena
M
Margeli
Alexandra
A
Hassiakos
Demetrios
D
Papassotiriou
Ioannis
I
Kanaka-Gantenbein
Christina
C
Malamitsi-Puchner
Ariadne
A
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000097:blood*; D009391:Nephelometry and Turbidimetry; D009414:Nerve Growth Factors / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011247:Pregnancy; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood
D015415:Biomarkers; D009414:Nerve Growth Factors; D017395:Plasminogen Activator Inhibitor 1; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D002097:C-Reactive Protein