title: Trehalose inhibits oral dryness by protecting the cell membrane.
abstract: This study assessed the clinical efficacy and acceptability of trehalose solution for oral dryness caused by dental treatment. The efficacy of trehalose on oral dryness under drying conditions was assessed by measuring the surface area of the fungiform papillae and the moisture content of the tongue in seven healthy volunteers. Based on the data from this pilot study, a clinical study was performed, in which the efficacy of oral trehalose spray was evaluated on oral dryness in 10 patients undergoing root canal treatment. The effects of trehalose on cell viability were also assessed under drying conditions in vitro. Trehalose suppressed oral dryness and associated pain caused by dental treatment and protected cells from dryness-related damage. These results indicate that pretreatment application of trehalose solution on the oral mucosa is effective in preventing oral dryness caused by dental treatment.
authors.affiliation: Sensory & Motor System Medicine, Faculty of Medicine, Japan. mori-ora@h.u-tokyo.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: F
authors.initials: F
authors.lastname: Yano
authors.forename: N
authors.initials: N
authors.lastname: Shimohata
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: U I
authors.initials: UI
authors.lastname: Chung
authors.forename: T
authors.initials: T
authors.lastname: Takato
mesh_terms: D000328:Adult; D000368:Aged; D002470:Cell Survival / Q000187:drug effects; D003890:Desiccation; D004187:Disaccharides / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects*; D010865:Pilot Projects; D012016:Reference Values; D012390:Root Canal Therapy / Q000009:adverse effects* / Q000295:instrumentation; D018709:Statistics, Nonparametric; D013396:Suction / Q000009:adverse effects; D013499:Surface Properties; D014199:Trehalose / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014987:Xerostomia / Q000209:etiology / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D004187:Disaccharides; D014199:Trehalose