Snap-top nanocarriers.
An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks, which are encircled by cucurbit[6]uril or alpha-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.
Ambrogio
Michael W
MW
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Pecorelli
Travis A
TA
Patel
Kaushik
K
Khashab
Niveen M
NM
Trabolsi
Ali
A
Khatib
Hussam A
HA
Botros
Youssry Y
YY
Zink
Jeffrey I
JI
Stoddart
J Fraser
JF
D001952:Bridged-Ring Compounds / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D047391:alpha-Cyclodextrins / Q000737:chemistry; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D007093:Imidazoles; D012235:Rhodamines; D012822:Silicon Dioxide; D047391:alpha-Cyclodextrins; C509968:MCM-41; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C029773:rhodamine B; C032613:alpha-cyclodextrin