title: Snap-top nanocarriers.
abstract: An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks, which are encircled by cucurbit[6]uril or alpha-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ambrogio
authors.forename: Travis A
authors.initials: TA
authors.lastname: Pecorelli
authors.forename: Kaushik
authors.initials: K
authors.lastname: Patel
authors.forename: Niveen M
authors.initials: NM
authors.lastname: Khashab
authors.forename: Ali
authors.initials: A
authors.lastname: Trabolsi
authors.forename: Hussam A
authors.initials: HA
authors.lastname: Khatib
authors.forename: Youssry Y
authors.initials: YY
authors.lastname: Botros
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D047391:alpha-Cyclodextrins / Q000737:chemistry; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D007093:Imidazoles; D012235:Rhodamines; D012822:Silicon Dioxide; D047391:alpha-Cyclodextrins; C509968:MCM-41; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C029773:rhodamine B; C032613:alpha-cyclodextrin