Molecular circuits of resolution in renal disease.
Inflammation is a common feature of renal pathology. Lipid mediators, such as lipoxins, resolvins, and protectins, can actively promote the resolution of inflammation by inhibiting polymorphonuclear cell infiltration to the site of inflammation, shifting the cytokine milieu from proinflammatory to proresolving and increasing the nonphlogistic phagocytosis of apoptotic cells by macrophages. Here we review the evidence for molecular circuits of resolution in renal disease.
Börgeson
Emma
E
UCD Diabetes Research Centre, UCD Conway Institute, School of Medicine and Medical Sciences, University College Dublin.
Godson
Catherine
C
D018957:CD59 Antigens / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D044045:Lipoxins / Q000378:metabolism
D018957:CD59 Antigens; D044045:Lipoxins; D004281:Docosahexaenoic Acids