A structural approach to decipher the neurexin and neuroligin splice isoform code.
The alternative splicing of neurexins (NRXs) and neuroligins (NLs) has been implicated in specifying synaptic connections. In this issue of Neuron, Koehnke et al. took a structural approach for assessing the contribution of alternative splice isoforms for beta-NRX/NL-mediated synaptic recognition.
Wei
Zhiyi
Z
Department of Biochemistry, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zhang
Mingjie
M