Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI.
Based on a commercially available hyperbranched aliphatic polyester, novel multifunctional gadolinium complexes were prepared bearing protective PEG chains, a folate targeting ligand and EDTA or DTPA chelate moieties. Their relatively high water relaxivity values coupled with biodegradability of the hyperbranched scaffold, folate receptor specificity render these non-toxic dendritic polymers promising candidates for MRI applications.
Sideratou
Zili
Z
Institute of Physical Chemistry, NCSR Demokritos, 15310 Aghia Paraskevi, Attiki, Greece. zili@chem.demokritos.gr
Tsiourvas
Dimitris
D
Theodossiou
Theodossis
T
Fardis
Michael
M
Paleos
Constantinos M
CM
D001672:Biocompatible Materials; D045744:Cell Line, Tumor; D003287:Contrast Media; D004492:Edetic Acid / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D004369:Pentetic Acid / Q000737:chemistry; D011091:Polyesters / Q000138:chemical synthesis*
D001672:Biocompatible Materials; D003287:Contrast Media; D011091:Polyesters; D004369:Pentetic Acid; D004492:Edetic Acid