title: Life-threatening haemorrhage secondary to nicorandil-induced severe peri-anal ulceration.
abstract: Nicorandil-induced ulceration is rare but has been reported at multiple sites throughout the gastrointestinal tract. We report a life-threatening complication of such ulceration - catastrophic per-rectal haemorrhage requiring emergency surgery with no prior symptoms. Whilst nicorandil should be considered in cases of chronic peri-anal and peristomal ulceration which fail to respond to conventional treatments, this case highlights its importance in the setting of acute surgical presentations.
authors.affiliation: Department of General Surgery, Bradford Royal Infirmary, Bradford, UK. Frances_Mosley@yahoo.co.uk
authors.forename: F
authors.initials: F
authors.lastname: Mosley
authors.forename: N
authors.initials: N
authors.lastname: Bhasin
authors.forename: J B
authors.initials: JB
authors.lastname: Davies
authors.forename: J R
authors.initials: JR
authors.lastname: Ausobsky
mesh_terms: D000208:Acute Disease; D000368:Aged; D001004:Anus Diseases / Q000209:etiology; D005401:Fissure in Ano / Q000139:chemically induced* / Q000150:complications / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D020108:Nicorandil / Q000009:adverse effects*; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil