Postsurgical inflammatory response is not associated with increased serum cystatin C values.
OBJECTIVE
Cystatin C is used both as a glomerular filtration (GFR) marker and a cardiovascular risk marker. There are several studies showing an association between cystatin C and inflammatory markers and it has been suggested that the inflammatory response in itself could result in elevated cystatin C levels. The aim of this study was to evaluate if an induced inflammatory response has an effect on cystatin C levels in humans.


METHODS
CRP and cystatin C were analyzed in serum samples from orthopedic surgery patients (n=29). The patients were sampled prior to surgery and four and thirty days after surgery.


RESULTS
The surgery induced a pronounced CRP elevation on day four, median 137.3 (interquartile range 104.1-178.2) mg/L compared to 1.94 (1.20-8.70) mg/L before surgery, P<0.001, but no significant difference in cystatin C levels before and four and thirty days after surgery could be seen.


CONCLUSIONS
The orthopedic surgery-induced inflammatory response does not cause changes in cystatin C levels.
Akerfeldt
Torbjörn
T
Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Helmersson
Johanna
J
Larsson
Anders
A
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects*; D011184:Postoperative Period
D015415:Biomarkers; D055316:Cystatin C; D002097:C-Reactive Protein