Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue.
Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or "click" synthetic methodology.
Stewart
Scott G
SG
School of Biomedical, Biomolecular and Chemical Science, University of Western Australia, 35 Stirling Hwy, Crawley, 6009, WA, Australia. sgs@cyllene.uwa.edu.au
Braun
Carlos J
CJ
Polomska
Marta E
ME
Karimi
Mahdad
M
Abraham
Lawrence J
LJ
Stubbs
Keith A
KA
D001710:Biotin / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry; D013237:Stereoisomerism; D013792:Thalidomide / Q000138:chemical synthesis / Q000737:chemistry*
D011092:Polyethylene Glycols; D013792:Thalidomide; D001710:Biotin