title: Rotigotine transdermal patch in the management of Parkinson's disease (PD) and its night-time use for PD-related sleep disorders.
abstract: Rotigotine (Neupro) is a non-ergolinic dopamine agonist available as a transdermal patch that can be applied once daily. To date, it is approved as monotherapy for the treatment of early Parkinson's disease (PD), and as adjunctive therapy to levodopa in the treatment of PD, including the advanced stage of the disease, when the efficacy of levodopa is reduced or becomes inconsistent and there are fluctuations in the therapeutic effect (end-dose, 'ON-OFF' phenomenon). The potential advantages of the rotigotine patch include immediacy of effect onset as intestinal absorption is not needed, constant drug delivery, and ease of use. This review provides an overview of several aspects of the use of the rotigotine transdermal patch, including the important issue of the management of sleep disorders in advanced PD patients, as well as the chemistry, preclinical and clinical pharmacology, efficacy, safety and tolerability of the drug. Furthermore, the rationale for the treatment of PD with the rotigotine transdermal patch is discussed, focusing in particular on the related sleep disorders.
authors.affiliation: Department for Parkinson's disease, IRCCS San Camillo, Venice, Italy. angelo3000@yahoo.com
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini
authors.forename: Laura
authors.initials: L
authors.lastname: Bernardi
authors.forename: Daniela
authors.initials: D
authors.lastname: Calandrella
authors.forename: Francesca
authors.initials: F
authors.lastname: Mancini
authors.forename: Mauro
authors.initials: M
authors.lastname: Plebani
mesh_terms: D000279:Administration, Cutaneous; D018491:Dopamine Agonists / Q000008:administration & dosage*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*
chemical_list: D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C047508:rotigotine