title: Cellular senescence predicts treatment outcome in metastasised colorectal cancer.
abstract: BACKGROUND
  Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown.
  
  
  METHODS
  A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis.
  
  
  RESULTS
  5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044).
  
  
  CONCLUSIONS
  Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed.
authors.affiliation: Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum der Charité - MKFZ, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Haugstetter
authors.forename: C
authors.initials: C
authors.lastname: Loddenkemper
authors.forename: D
authors.initials: D
authors.lastname: Lenze
authors.forename: J
authors.initials: J
authors.lastname: Gröne
authors.forename: C
authors.initials: C
authors.lastname: Standfuss
authors.forename: I
authors.initials: I
authors.lastname: Petersen
authors.forename: B
authors.initials: B
authors.lastname: Dörken
authors.forename: C A
authors.initials: CA
authors.lastname: Schmitt
mesh_terms: D016922:Cellular Senescence; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000503:physiopathology* / Q000556:secondary; D018572:Disease-Free Survival; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D011237:Predictive Value of Tests; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D002955:Leucovorin; D005472:Fluorouracil