Grabbing amphiregulin by the tail to better understand keratinocyte growth.
Amphiregulin (AREG) is an important regulator of cellular growth in keratinocytes, carcinomas, and hyperproliferative epidermal disorders, including psoriasis. Stoll and colleagues present data suggesting that the cytoplasmic carboxy-terminal domain of amphiregulin plays an important role in regulating autocrine keratinocyte growth through the epidermal growth factor receptor. These observations raise novel and interesting biological questions regarding the function of the cytoplasmic C-terminal region of AREG.
Seykora
John T
JT
Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19101, USA. john.seykora@uphs.upenn.edu
D066258:Amphiregulin; D066255:EGF Family of Proteins; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000378:metabolism*; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*
C587848:AREG protein, human; D066258:Amphiregulin; D066255:EGF Family of Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins