T helper cell differentiation: understanding the needs of hierarchy.
In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.
Weichhart
Thomas
T
Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. thomas.weichhart@meduniwien.ac.at
Säemann
Marcus D
MD