title: Management of a parturient with high-grade osteosarcoma of the proximal femur: a multidisciplinary approach.
abstract: Osteosarcoma is the most common primary malignant bone tumor, yet it is exceedingly rare in pregnancy. We present a case of a 33-year-old multiparous woman diagnosed with high-grade osteosarcoma during the third trimester of pregnancy. A plan was formulated to perform cesarean delivery at 33 weeks of gestation under spinal anesthesia, and, in subsequent surgery, radical femoral neck resection with limb salvage and adjuvant chemotherapy. The outcome was a healthy newborn baby boy and a disease-free mother. This case highlights the benefits of multidisciplinary planning: balancing the needs of the developing fetus with those of the mother, mitigating the risk of pathologic fracture and ensuring timely oncologic therapy.
authors.affiliation: Department of Anesthesia and Critical Care, General Hospital, 55 Fruit Street, Boston, MA 02114-2622, USA. aquaye@partners.org
authors.forename: A A
authors.initials: AA
authors.lastname: Quaye
authors.forename: K A
authors.initials: KA
authors.lastname: Raskin
authors.forename: J L
authors.initials: JL
authors.lastname: Ecker
authors.forename: L R
authors.initials: LR
authors.lastname: Leffert
mesh_terms: D000328:Adult; D005260:Female; D005266:Femoral Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D023821:Limb Salvage; D008279:Magnetic Resonance Imaging; D008297:Male; D012516:Osteosarcoma / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D010348:Patient Care Team; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D011859:Radiography