title: Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women.
abstract: Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were significantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, alpha-1 and alpha-2 levels were significantly lower. Over 1 year, significant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and prebeta-1 levels were observed with significant increases of HDL-C and alpha-1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol (P = 0.018) and LCAT mass (P = 0.011), but not with CETP mass (P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass (P = 0.005) and alpha-1 level (P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass (P = 0.043) and inversely with changes of alpha-1 (P = 0.03) and alpha-2 (P = 0.05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients.
authors.affiliation: Lipid Metabolism Laboratory, Human Nutrition Research Center at Tufts University, Boston, MA, USA. bela.asztalos@tufts.edu
authors.forename: Bela F
authors.initials: BF
authors.lastname: Asztalos
authors.forename: Michael M
authors.initials: MM
authors.lastname: Swarbrick
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Schaefer
authors.forename: Gerard E
authors.initials: GE
authors.lastname: Dallal
authors.forename: Katalin V
authors.initials: KV
authors.lastname: Horvath
authors.forename: Masumi
authors.initials: M
authors.lastname: Ai
authors.forename: Kimber L
authors.initials: KL
authors.lastname: Stanhope
authors.forename: Iselin
authors.initials: I
authors.lastname: Austrheim-Smith
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Wolfe
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ali
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000378:metabolism; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D009767:Obesity, Morbid / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D012306:Risk; D015431:Weight Loss
chemical_list: D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL; D007862:Phosphatidylcholine-Sterol O-Acyltransferase