title: Application of visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry eye disease.
abstract: OBJECTIVE
  To investigate the applicability of tear meniscus height (TMH) measurement using Visante optical coherence tomography (OCT) in the diagnosis of dry eye disease.
  
  
  METHODS
  Prospective, controlled, single-center study.
  
  
  METHODS
  Twenty-four right eyes of 24 patients (6 males, 18 females; mean age, 63.14±13.4 years) with definite dry eye according to the Japanese dry eye diagnostic criteria and 27 right eyes of 27 control subjects (12 males, 15 females; mean age, 56.04±14.22 years) were recruited.
  
  
  METHODS
  All subjects underwent slit-lamp TMH measurement, OCT upper and lower TMH measurements, tear film breakup time (BUT) measurements, vital stainings, and Schirmer test. The results were compared between the 2 groups by Mann-Whitney test.
  
  
  METHODS
  The correlation between the clinical findings of slit-lamp TMH, strip meniscometry examination, tear functions, vital staining scores, and the OCT upper and lower TMH parameters were tested by Spearman's correlation test. Receiver operating characteristic (ROC) curve technique was used to evaluate the sensitivity, specificity and cutoff values of OCT TMH examination in the diagnosis of dry eye.
  
  
  RESULTS
  The OCT upper and lower TMH values, slit-lamp TMH, strip meniscometry, tear film BUT, and vital staining scores were significantly lower in the dry eye patients compared with controls (P<0.001). A significant correlation between the OCT upper and lower TMH measurements as well as slit-lamp TMH, strip meniscometry, tear functions, vital staining scores, and the Schirmer test was found. The ROC curve technique analysis of the OCT lower TMH showed that, when the cutoff value was set at <0.30 mm, the sensitivity and specificity of the testing were 67% and 81%, respectively.
  
  
  CONCLUSIONS
  The Visante OCT is a quick, noninvasive method for assessing the TMH, with acceptable sensitivity, specificity, and repeatability, and may have potential applications for the diagnosis and evaluation of dry eye disease.
authors.affiliation: Keio University School of Medicine, Johnson & Johnson Ocular Surface and Visual Optics Department, Tokyo, Japan.
authors.forename: Osama M A
authors.initials: OM
authors.lastname: Ibrahim
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Yoji
authors.initials: Y
authors.lastname: Takano
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Satake
authors.forename: Tais Hitomi
authors.initials: TH
authors.lastname: Wakamatsu
authors.forename: Kazumi
authors.initials: K
authors.lastname: Fukagawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujishima
mesh_terms: D015352:Dry Eye Syndromes / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013666:Tears / Q000737:chemistry*; D041623:Tomography, Optical Coherence