title: Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation.
abstract: Nanodiamonds (NDs) are receiving increasing attention in materials science and nanotechnology-based industries for a large variety of applications, including protein immobilization, biosensors, therapeutic molecule delivery, and bioimaging. However, limited information is known about their biokinetic behavior and toxicity in vivo. In this article, we investigated the biodistribution of NDs using radiotracer techniques and evaluated its acute toxicity in Kun Ming mice after intratracheal instillation. The biodistribution showed that, besides having the highest retention in the lung, NDs were distributed mainly in the spleen, liver, bone and heart. An analysis of histological morphology and biochemical parameters indicated that NDs could induce dose-dependent toxicity to the lung, liver, kidney and blood. This work provided fundamental data for understanding the biodistribution of NDs and will provide guidance for further study of their toxicity.
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 2019 Jialuo Road, Jiading, Shanghai 201800, China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhang
authors.forename: Jilei
authors.initials: J
authors.lastname: Yin
authors.forename: Cheng
authors.initials: C
authors.lastname: Kang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Wenxin
authors.initials: W
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D018130:Diamond / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007442:Intubation, Intratracheal; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D009928:Organ Specificity; D014018:Tissue Distribution; D023382:Toxicity Tests, Acute
chemical_list: D018130:Diamond