title: Blood pressure and medication during long-term antihypertensive therapy based on morning home SBP in hypertensive patients: Hypertension Control Based on Home Systolic Pressure (HOSP) substudy.
abstract: We examined blood pressure (BP) and medication over 5 years in 80 hypertensive patients who participated in the Hypertension Control Based on home systolic pressure (HOSP) study that compares effects of strict and mild control of morning home systolic blood pressure (SBP) as well as amlodipine- and losartan-based regimens. Average morning home SBP after 5 years was 126 mmHg in the strict control group and 135 mmHg in the mild control group. The strict control group and the losartan group required more combination therapy than the other groups. These results show that long-term strict control of morning BP is feasible. Amlodipine appears to be more effective in controlling morning BP than losartan when the medication is administered alone in the morning.
authors.affiliation: Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan. ykawano@hsp.ncvc.go.jp
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kawano
authors.forename: Takeshi
authors.initials: T
authors.lastname: Horio
authors.forename: Kei
authors.initials: K
authors.lastname: Kamide
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Iwashima
authors.forename: Fumiki
authors.initials: F
authors.lastname: Yoshihara
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D004359:Drug Therapy, Combination; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007564:Japan; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine; D019808:Losartan