In vitro antibacterial activity of Ibuprofen and acetaminophen.
BACKGROUND
Ibuprofen and acetaminophen are common chemical agents that have anti-inflammatory, antipyretic, and analgesic activity.


OBJECTIVE
To detect any potential antibacterial effects of ibuprofen and acetaminophen on pathogenic bacteria.


METHODS
Ibuprofen and acetaminophen were tested for antibacterial activity against seven isolates of bacteria including gram positive bacteria (Staphylococci aureus and Bacillus subtilis) and gram negative bacteria (E. coli, Enterobacter aerogenes, Enterobacter cloacae, Salmonella typhi and Paracoccus yeei). Spectrophotometer assay was applied to determine the antibacterial activities of ibuprofen and acetaminophen. Three controls were included in this study: Ampicilline sodium (20 mug/ml); cefotaxime sodium (20 mug/ml) and chemical free medium.


RESULTS
Staphylococcus aureus and Paracoccus yeei were susceptible to lower concentrations of ibuprofen and acetaminophen (MIC=1.25 mg/ml), while two strains of Enterobacter exhibited resistance to these agents.


CONCLUSIONS
Ibuprofen and acetaminophen showed a potential antibacterial effect on isolated strains of bacteria. They had the same ability to inhibit bacterial growth.
Al-Janabi
Ali Abdul Hussein S
AA
Department of Clinical Laboratory, University of Karbala, Collage of Pharmacy, Iraq.