title: Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.
abstract: Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).
authors.affiliation: Department of Medical Radiation Physics, Lund University.
authors.forename: Ronnie
authors.initials: R
authors.lastname: Wirestam
authors.affiliation: Department of Medical Radiation Physics, Lund University.
authors.forename: Emelie
authors.initials: E
authors.lastname: Lindgren
authors.affiliation: Center for Medical Imaging and Physiology, Skåne University Hospital, Lund.|Department of Diagnostic Radiology, Lund University.
authors.forename: Danielle
authors.initials: D
authors.lastname: Van Westen
authors.affiliation: Philips Medical Systems, Lund, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Markenroth Bloch
authors.affiliation: Department of Medical Radiation Physics, Lund University.|Department of Diagnostic Radiology, Lund University.
authors.forename: Freddy
authors.initials: F
authors.lastname: Ståhlberg
authors.affiliation: Department of Medical Radiation Physics, Lund University.
authors.forename: Linda
authors.initials: L
authors.lastname: Knutsson
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D008955:Models, Cardiovascular; D009942:Organometallic Compounds; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D013113:Spin Labels; D013548:Sweden; D013997:Time Factors
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D013113:Spin Labels; D008536:Meglumine; C072417:gadoterate meglumine