title: Modelling trachoma for control programmes.
abstract: Trachoma is a major cause of blindness in the developing world and 63 million people are currently infected. Large-scale control programmes are being implemented to clear ocular Chlamydia trachomatis infection--the causative agent of trachoma--and improve environmental conditions to reduce transmission. Chemotherapeutic intervention involves antibiotic administration and the effectiveness of this treatment is currently under investigation. A mathematical model has been developed to allow the impact of control programmes on infection and blinding disease sequelae to be predicted. The model has a structure that allows an important aspect of trachoma pathogenesis to be taken into account, namely the effect of repeated cycles of infection and recovery leading to scarring and the damaging disease sequelae. This novel model structure reproduces many age- and time-dependent epidemiological patterns observed in endemic settings and allows the dynamic effect of treatment on infection and disease sequelae to be gauged.
authors.affiliation: Department of Infectious Disease Epidemiology, Faculty of Medicine, St. Mary's campus, Imperial College London, Norfolk Place, London W2 1PG, UK. m.gambhir@imperial.ac.uk
authors.forename: Manoj
authors.initials: M
authors.lastname: Gambhir
authors.forename: María-Gloria
authors.initials: MG
authors.lastname: Basáñez
authors.forename: Isobel M
authors.initials: IM
authors.lastname: Blake
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Grassly
mesh_terms: D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017963:Azithromycin / Q000008:administration & dosage; D001766:Blindness / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008954:Models, Biological; D014141:Trachoma / Q000150:complications / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin