Protein kinase C/mitogen-activated protein kinase signaling in keratinocyte differentiation control.
Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is altered in many common skin diseases. Keratinocyte differentiation is controlled by a complex signaling network involving multiple members of the protein kinase C and mitogen-activated protein kinase signaling kinases. Using an RNA interference knockdown approach, Adhikary et al. identified essential nodes in this signaling network, revealing remarkable kinase specificity.
Denning
Mitchell F
MF
Department of Pathology and the Cardinal Bernardin Cancer Center, Skin Cancer Research Program, Loyola University Chicago, Maywood, Illinois 60153, USA. mdennin@lumc.edu
D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D011493:Protein Kinase C; D020928:Mitogen-Activated Protein Kinases