title: Analysis of cyclin-dependent kinase inhibitor 1B mutation in Han Chinese women with premature ovarian failure.
abstract: The gene for cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as P27(KIP1) and P27) encodes a cyclin-dependent kinase inhibitor and controls ovarian development in mice. In p27-deficient (p27(-/-)) mice, the overactivated follicular pool in ovaries was largely depleted, causing premature ovarian failure. The goal of this research was to investigate whether there are nucleotide changes in the CDKN1B gene of Han Chinese women with premature ovarian failure, as compared with control volunteers using candidate gene sequencing. No novel variations were found in exons encoding for CDKN1B. So the mutations in CDKN1B are not common with premature ovarian failure in Han Chinese women.
authors.affiliation: Graduate School, Peking Union Medical College, Beijing, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Ni
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Zhaolian
authors.initials: Z
authors.lastname: Wei
authors.forename: Xianglong
authors.initials: X
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D017931:DNA Primers; D005006:Ethnicity; D005260:Female; D006801:Humans; D009154:Mutation; D016649:Primary Ovarian Insufficiency / Q000235:genetics*
chemical_list: D017931:DNA Primers; D050760:Cyclin-Dependent Kinase Inhibitor p27