title: The epidemiology of bone cancer in 0 - 39 year olds in northern England, 1981 - 2002.
abstract: BACKGROUND
  There is a paucity of recent epidemiological data on bone cancers. The aim of this study was to describe incidence and survival patterns for bone cancers diagnosed during 1981 - 2002.
  
  
  METHODS
  Cases aged 0 - 39 years (236 osteosarcomas, 166 Ewing sarcomas and 73 chondrosarcomas) were analysed using Poisson and Cox regressions.
  
  
  RESULTS
  Incidence rates (per million persons per year) for osteosarcoma were 2.5 at age 0 - 14 years; 4.5 at age 15 - 29 years and 1.0 at age 30 - 39 years. Similarly, for Ewing sarcoma the incidence rates were 2.2; 2.9; 0.4 and for chondrosarcoma rates were 0.1; 1.2; 1.8 respectively. Incidence of osteosarcoma increased at an average annual rate of 2.5% (95% CI 0.4 - 4.7; P = 0.02), but there was no change in incidence of Ewing sarcoma or chondrosarcoma. There was a marginally statistically significant improvement in survival for Ewing sarcoma (hazard ratio (HR) per annum = 0.97; 95% CI 0.94 - 1.00; P = 0.06), although patients aged 15 - 39 years (n = 93) had worse overall survival than those aged 0 - 14 (n = 73; HR = 1.46; 95% CI 0.98 - 2.17; P = 0.06). There was no significant improvement in osteosarcoma survival (HR per annum = 0.98; 95% CI 0.95 - 1.01; P = 0.18).
  
  
  CONCLUSIONS
  Reasons for poorer survival in Ewing sarcoma patients aged 15 - 39 years and failure to significantly improve survival for osteosarcoma patients requires further investigation.
authors.affiliation: Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, England, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Eyre
authors.forename: Richard G
authors.initials: RG
authors.lastname: Feltbower
authors.forename: Peter W
authors.initials: PW
authors.lastname: James
authors.forename: Karen
authors.initials: K
authors.lastname: Blakey
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mubwandarikwa
authors.forename: David
authors.initials: D
authors.lastname: Forman
authors.forename: Patricia A
authors.initials: PA
authors.lastname: McKinney
authors.forename: Mark S
authors.initials: MS
authors.lastname: Pearce
authors.forename: Richard J Q
authors.initials: RJ
authors.lastname: McNally
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002813:Chondrosarcoma / Q000453:epidemiology* / Q000473:pathology; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000453:epidemiology* / Q000473:pathology; D011379:Prognosis; D012042:Registries; D012512:Sarcoma, Ewing / Q000453:epidemiology* / Q000473:pathology; D015996:Survival Rate; D013997:Time Factors; D055815:Young Adult