title: Response to trabectedin treatment in a highly pretreated patient with an advanced meningeal hemangiopericytoma.
abstract: Meningeal hemangiopericytoma is an uncommon and aggressive malignancy that, in contrast to meningiomas, shows a high propensity for local recurrence and the development of late extraneural metastases. The results of chemotherapy in advanced hemangiopericytoma have been disappointing, and they have been particularly poor in cases located in the meninges. We report a case of a heavily pretreated metastatic meningeal hemangiopericytoma in which fourth-line chemotherapy with trabectedin, a marine-derived antineoplastic agent effective in treating advanced soft tissue sarcomas, resulted in clinical benefit.
authors.affiliation: Department of Medical Oncology, Hospital Universitario Miguel Servet, Zaragoza, Spain. jmtrufero@seom.org
authors.forename: Javier
authors.initials: J
authors.lastname: Martinez-Trufero
authors.forename: Jorge
authors.initials: J
authors.lastname: Alfaro
authors.forename: Francesc
authors.initials: F
authors.lastname: Felipo
authors.forename: Maria
authors.initials: M
authors.lastname: Alvarez
authors.forename: Julia
authors.initials: J
authors.lastname: Madani
authors.forename: Ana
authors.initials: A
authors.lastname: Cebollero
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D004149:Dioxoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006393:Hemangiopericytoma / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy*; D009367:Neoplasm Staging; D044005:Tetrahydroisoquinolines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000077606:Trabectedin; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004149:Dioxoles; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin