Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut.
BACKGROUND
Infants with parenteral nutrition dependence may develop liver dysfunction and progress to liver failure requiring transplantation. The aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in adults. This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis progression.


METHODS
Laboratory values and biopsies were collected from initial intestinal resection (time 0) up to transplantation (end). Fibrosis scoring ranged from F0 (normal) to F4 (cirrhosis). Children were divided into 3 groups: (1) isolated intestine; and combined liver/intestine with gestational age (2) 34 weeks or greater and (3) 30 weeks or less. Liver function values over time, including calculated APRI, were analyzed as predictors of fibrosis.


RESULTS
Fifteen children who had 33 biopsies were included. Median APRI by fibrosis grade was F < or = 2: 1.88, F3: 3.23, and F4: 14.16 (P < .01). Median APRI at transplant by study group was (1) isolated intestine: 2.47, (2) liver/intestine 35 weeks or longer EGA: 14.16, and (3) liver/intestine 30 weeks or less EGA: 14.74 (P = .04).


CONCLUSIONS
Progression of APRI up to 60 days initially demonstrates similar values among study groups, but over time the score distinguishes those children with impending liver cirrhosis and differentiates fibrosis grade and study group.
Mangus
Richard S
RS
Department of Surgery, Transplant Section, Indiana University School of Medicine, Indianapolis, IN 46202-5250, USA. rmangus@iupui.edu
O'Connor
Michael G
MG
Tector
A Joseph
AJ
Lim
Joel D
JD
Vianna
Rodrigo M
RM
D001219:Aspartate Aminotransferases / Q000097:blood*; D001706:Biopsy; D001792:Blood Platelets / Q000473:pathology*; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery*; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D010288:Parenteral Nutrition; D010976:Platelet Count; D011379:Prognosis; D012778:Short Bowel Syndrome / Q000097:blood / Q000150:complications* / Q000628:therapy
D001219:Aspartate Aminotransferases