title: Role of haematological testing: ratio values of circulating platelet aggregates in visual field loss associated with pseudoexfoliation glaucoma.
abstract: The aim of the work is to examine the role of circulating platelet aggregates (CPAs) in association with pseudoexfoliation glaucoma (PXG) and searching for visual field (VF) progression. The impact of CPAs in association with PXG and ischaemic events related to optic nerve damage and VF progression has not been so far sufficiently explained. The examination included 80 patients, of whom 35 (44 %) were men with average age of 68.3 +/- 7.0 and 45 (56 %) were women with average age of 65.7 +/- 7.0 (t = 1.66; p = 0.101). Forty of them suffered from primary open-angle glaucoma (POAG) and were included into a control (healthy) group, and 40 patients suffered from pseudoexfoliative glaucoma (PXG) and were included into the experimental group. All the examinees underwent complete ophthalmologic examination of visual acuity, ocular fundus, intraocular pressure and anterior eye segment by biomicroscopy and gonioscopy. In addition, VF examination was performed three times in six-month intervals. Laboratory testing of CPA proportion values was performed by means of Wu an Hoak method. The obtained decreased values of CPA proportion were caused by hypercoagulability of blood in PXG group resulting finally in ischaemia and hypoxia helping the progression of visual field. In conclusion, our study shows that CPA examination improves the assessment of the vascular role and PXG prognosis (Tab. 3, Ref. 30).
authors.affiliation: Department of Ophthalmology, Split University Hospital, Split, Croatia. veljko.rogosic@st.t-com.hr
authors.forename: V
authors.initials: V
authors.lastname: Rogosic
authors.forename: L
authors.initials: L
authors.lastname: Bojic
authors.forename: K
authors.initials: K
authors.lastname: Karaman
authors.forename: Rogosic L
authors.initials: RL
authors.lastname: Vanjaka
authors.forename: M
authors.initials: M
authors.lastname: Titlic
authors.forename: I
authors.initials: I
authors.lastname: Plestina-Borijan
authors.forename: S
authors.initials: S
authors.lastname: Miljak
authors.forename: K
authors.initials: K
authors.lastname: Poljak
authors.forename: D
authors.initials: D
authors.lastname: Duplancic
mesh_terms: D000368:Aged; D017889:Exfoliation Syndrome / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood / Q000503:physiopathology; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D014794:Visual Fields