title: Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Body mass index (BMI) is closely associated with mortality in chronic obstructive pulmonary disease (COPD). Systemic inflammation has been suggested as one of the mechanisms of malnutrition in COPD. This study investigated the relationships of clinical variables and inflammatory biomarkers with BMI in COPD in an aging population.
  
  
  METHODS
  Baseline levels of serum biomarkers were determined for 69 patients with stable male COPD. Multivariate logistic regression was used to evaluate associations between clinical variables, including emphysema scores, and biomarkers with BMI.
  
  
  RESULTS
  Twenty eight patients were categorized as low BMI (<20 kg/m2). BMI was inversely correlated with serum α1-antitrypsin (α1-AT) concentration and emphysema scores, and was positively correlated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). Multivariate logistic regression analysis showed that α1-AT was independently associated with BMI.
  
  
  CONCLUSIONS
  Low BMI was associated with the severity of emphysema and systemic inflammation reflected by elevated α1-AT level.
authors.affiliation: Department of Rehabilitation Medicine, Kinki University School of Medicine, Osaka, Japan. yhigashi@med.kindai.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Higashimoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamagata
authors.forename: Noritsugu
authors.initials: N
authors.lastname: Honda
authors.forename: Ryuji
authors.initials: R
authors.lastname: Satoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sano
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwanaga
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyhara
authors.forename: Masato
authors.initials: M
authors.lastname: Muraki
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tomita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tohda
authors.forename: Kanji
authors.initials: K
authors.lastname: Fukuda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers