Prospective study on dialysis patients after total parathyroidectomy without autoimplant.
OBJECTIVE
Secondary hyperparathyroidism is common in chronic kidney disease. When medical treatment fails, subtotal or total parathyroidectomy with autoimplant is done but both are associated with a high recurrence rate. The third surgical strategy is total parathyroidectomy without autoimplant. We evaluate the outcomes of patients who had total parathyroidectomy with no autoimplant.


METHODS
Thirteen patients who had total parathyroidectomy without autoimplant were prospectively studied from 1998-2002. Intact parathyroid hormone, biochemistry and bone mineral densities were measured at baseline and serially. All patients had bone biopsies done preoperatively and seven had repeat bone biopsies at a mean of 37.7 months postoperatively. Histomorphometric studies were done for all bone biopsies. Patients were observed for fractures.


RESULTS
Five patients were on haemodialysis and eight on peritoneal dialysis. Mean duration of follow up was 68 months. Postoperatively, mean intact parathyroid hormone decreased precipitously and remained within or just above normal. Mean serum calcium phosphate product decreased and remained normal. Out of seven patients who had repeat bone biopsies, two showed reversal of hyperparathyroid bone disease to normal, two had mild hyperparathyroidism, while three had adynamic bone disease. One patient with adynamic bone disease subsequently developed biochemical recurrence of hyperparathyroidism. Serial bone densitometry showed remarkable improvement. There was no fracture.


CONCLUSIONS
In the studied series of total parathyroidectomy without autoimplant, adynamic bone disease occurred in three out of seven repeat bone biopsies while improvement occurred in the rest. Bone mineral density was much improved and there was no fracture.
Chan
Hilda Wai-Han
HW
Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China. chanwhh@ha.org.hk
Chu
Kwok-Hong
KH
Fung
Samuel Ka-Shun
SK
Tang
Hon-Lok
HL
Lee
William
W
Cheuk
Au
A
Yim
Ka-Fai
KF
Tong
Matthew Kwok-Lung
MK
Lee
Kam-Cheong
KC
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002118:Calcium / Q000097:blood; D002681:China; D002908:Chronic Disease; D005260:Female; D005272:Femur Neck / Q000473:pathology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000628:therapy*; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010530:Peritoneal Dialysis; D010710:Phosphates / Q000097:blood; D011446:Prospective Studies; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; C470125:PTH protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium