Control of reflexive saccades following hemispherectomy.
Individuals who have undergone hemispherectomy for treatment of intractable epilepsy offer a rare and valuable opportunity to examine the ability of a single cortical hemisphere to control oculomotor performance. We used peripheral auditory events to trigger saccades, thereby circumventing dense postsurgical hemianopia. In an antisaccade task, patients generated numerous unintended short-latency saccades toward contralesional auditory events, indicating pronounced limitations in the ability of a single hemicortex to exert normal inhibitory control over ipsilateral (i.e., contralesional) reflexive saccade generation. Despite reflexive errors, patients retained an ability to generate correct antisaccades in both directions. The prosaccade task revealed numerous contralesional express saccades, a robust contralesional gap effect, but the absence of both effects for ipsilesional saccades. These results indicate limits to the saccadic control capabilities following hemispherectomy: A single hemicortex can mediate antisaccades in both directions, but plasticity does not extend fully to the bilateral inhibition of reflexive saccades. We posit that these effects are due to altered control dynamics that reduce the responsivity of the superior colliculus on the intact side and facilitate the release of an auditory-evoked ocular grasp reflex into the blind hemifield that the intact hemicortex has difficulty suppressing.
Reuter-Lorenz
Patricia A
PA
Department of Psychology, University of Michigan, Ann Arbor, MI 48109-1043, USA. parl@umich.edu
Herter
Troy M
TM
Guitton
Daniel
D
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D005133:Eye Movements / Q000502:physiology; D005260:Female; D038421:Hemispherectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology