title: Decreasing glioma recurrence through adjuvant cancer stem cell inhibition.
abstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This recurrence perhaps, is as a consequence of the failure to eradicate a tumor cell subpopulation, termed cancer stem cells. Isolating, characterizing, and understanding these tumor-initiating cells through cellular and molecular markers, along with genetic and epigenetic understanding will allow for selective targeting through therapeutic agents and holds promise for decreasing glioma recurrence.
authors.affiliation: Division of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USA.
authors.forename: Josh
authors.initials: J
authors.lastname: Neman
authors.forename: Rahul
authors.initials: R
authors.lastname: Jandial