Long-term follow-up study of clear cell papulosis.
BACKGROUND
Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown.


OBJECTIVE
The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome.


METHODS
Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed.


RESULTS
With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density.


CONCLUSIONS
Retrospective nature of the study is a limitation.


CONCLUSIONS
No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.
Tseng
Fang-Wen
FW
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Kuo
Tseng-Tong
TT
Lu
Pei-Hsuan
PH
Chan
Heng-Leong
HL
Chan
Ming-Jing
MJ
Hui
Rosaline Chung-Yee
RC
D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017496:Hypopigmentation / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D018396:Mucin-1 / Q000378:metabolism; D010145:Paget Disease, Extramammary / Q000473:pathology; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling; D013997:Time Factors
D002272:Carcinoembryonic Antigen; D018396:Mucin-1