title: Short-term effect of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with obstructive sleep apnea.
abstract: CONCLUSIONS
  This study shows the possibility that multilevel surgery for obstructive sleep apnea (OSA) is helpful to improve the levels of pro-inflammatory cytokines and adipokines, which are related to complications of OSA.
  
  
  OBJECTIVE
  The effects of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with OSA were assessed.
  
  
  METHODS
  Fifty-one patients with OSA underwent uvulopalatopharyngoplasty and radiofrequency tongue base reduction. Body mass index (BMI), Epworth sleepiness scale (ESS) and subjective symptoms using visual analog scales were assessed at baseline and 4 weeks after treatment. Adiponectin, leptin, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were measured with a LINCOplex Human Immunoassay at baseline and 4 weeks after surgical treatment.
  
  
  RESULTS
  Significant improvements in subjective symptoms and ESS were found at 4 weeks after multilevel surgery. No significant change in BMI was observed. Adiponectin level was significantly increased after surgical treatment. Postoperative leptin, IL-6, and TNF-α levels were significantly decreased. The percent changes of adiponectin, leptin, IL-6, and TNF-α after multilevel surgery were not significantly different among patients with mild, moderate, and severe OSA.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea.
authors.forename: Young Gyu
authors.initials: YG
authors.lastname: Eun
authors.forename: Myung Gu
authors.initials: MG
authors.lastname: Kim
authors.forename: Kee Hwan
authors.initials: KH
authors.lastname: Kwon
authors.forename: Seung Youp
authors.initials: SY
authors.lastname: Shin
authors.forename: Joong Saeng
authors.initials: JS
authors.lastname: Cho
authors.forename: Sung Wan
authors.initials: SW
authors.lastname: Kim
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood*; D004598:Electrosurgery; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010160:Palate, Soft / Q000601:surgery; D017060:Patient Satisfaction; D010614:Pharynx / Q000601:surgery; D017286:Polysomnography; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery*; D014059:Tongue / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014609:Uvula / Q000601:surgery
chemical_list: D054392:Adipokines; D052242:Adiponectin; D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha