title: Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A.
abstract: Eighteen schizandrin A derivatives, possessing an acyl group at 7-OH and/or halogen(s) at C-4 and C-11, were designed and synthesized for evaluation of their in vitro ability to inhibit multidrug resistance (MDR). They exhibit weak ability to restore the intracellular Rhodamine 123 in human hepatocarcinoma MDR cell lines Bel7402 and HCT8 relative to the reference drug verapamil.
authors.affiliation: Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Liang
authors.forename: Geng-Tao
authors.initials: GT
authors.lastname: Liu
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Chen
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Wang
mesh_terms: D034242:Cyclooctanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020112:Rhodamine 123 / Q000032:analysis; D032141:Schisandra / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; D020112:Rhodamine 123; C034734:schizandrin A