Human kallikrein 8 expression in salivary gland tumors.
The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum. It has also been shown to be a biomarker and prognostic factor for breast cancer. The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.
Darling
Mark R
MR
Division of Oral Pathology, Department of Pathology, University of Western Ontario, 1151 Richmond Street, London, Ontario, Canada. mark.darling@schulich.uwo.ca
Tsai
Sam
S
Jackson-Boeters
Linda
L
Daley
Thomas D
TD
Diamandis
Eleftherios P
EP
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D018267:Carcinoma, Acinar Cell / Q000378:metabolism / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007610:Kallikreins / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012470:Salivary Glands, Minor / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; C094799:KLK8 protein, human; D007610:Kallikreins