Micro- and nanocantilever devices and systems for biomolecule detection.
Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically improved through the advent of new materials and micro-/nanofabrication technologies. This is especially true for micro-/nanosized cantilever sensors, which undergo a change in mechanical properties upon the specific binding of biomolecules. In this review, we introduce the basic principles of cantilever biosensors in static and dynamic modes. We also summarize a range of approaches to cantilever design, fabrication, and instrumentation according to their applications. More specifically, we describe cantilever-based detections of proteins, DNA molecules, bacteria, and viruses and discuss current challenges related to the targets' biophysical characteristics.
Hwang
Kyo Seon
KS
Nano-Bio Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
Lee
Sang-Myung
SM
Kim
Sang Kyung
SK
Lee
Jeong Hoon
JH
Kim
Tae Song
TS
D000818:Animals; D001419:Bacteria / Q000302:isolation & purification; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004247:DNA / Q000032:analysis; D006801:Humans; D008904:Miniaturization / Q000295:instrumentation / Q000379:methods; D011506:Proteins / Q000032:analysis; D014780:Viruses / Q000302:isolation & purification
D011506:Proteins; D004247:DNA