Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy.
In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4 T-cell counts less than 350 microl were distinct from HIV-infected individuals with more than 350 CD4 T-cell counts/microl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-gamma-secreting CD4 T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.
Fritz
Stefanie
S
Department of Biomedicine, Basel University, Switzerland.
Mossdorf
Erik
E
Durovic
Bojana
B
Zenhaeusern
Gabriela
G
Conen
Anna
A
Steffen
Ingrid
I
Battegay
Manuel
M
Nüesch
Reto
R
Hess
Christoph
C
D000914:Antibodies, Viral / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*
D000914:Antibodies, Viral; D007252:Influenza Vaccines