title: Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
abstract: Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bio-assays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyanoenones of boswellic acid and glycyrrhetinic acid.
authors.affiliation: Department of Organic chemistry, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: G S R
authors.initials: GS
authors.lastname: Subba Rao
authors.forename: Paturu
authors.initials: P
authors.lastname: Kondaiah
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Singh
authors.forename: Palaniyandi
authors.initials: P
authors.lastname: Ravanan
authors.forename: Michael B
authors.initials: MB
authors.lastname: Sporn