4,4'-Methylenedianiline-induced hepatitis in an industrial worker: case report and review of the literature.
4,4'-Methylenedianiline (MDA) is a chemical used in manufacturing and insulation processes and is a well-known hepatotoxin. We report the case of a 42-year-old construction-site worker who was accidentally exposed to large amounts of MDA and developed acute liver damage. The clinical course is described, with particular emphasis on the timely identification of the underlying cause and prompt management that led to an uneventful recovery. We review the relevant literature and discuss the safety measures necessary to minimize similar occupational hazards in industrial workers.
Giouleme
Olga
O
First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece. olgagi@med.auth.gr
Karabatsou
Sofia
S
Hytiroglou
Prodromos
P
Xanthis
Andreas
A
Tsiaousi
Eleni
E
Katsaros
Marios
M
Koliouskas
Dimitrios
D
D000208:Acute Disease; D000328:Adult; D000485:Allergens / Q000633:toxicity*; D000814:Aniline Compounds / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009784:Occupational Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome; D001559:Benzhydryl Compounds
D000485:Allergens; D000814:Aniline Compounds; D008775:Methylprednisolone; C009505:4,4'-diaminodiphenylmethane; D001559:Benzhydryl Compounds