Highly efficient production of [(18)F]fallypride using small amounts of base concentration.
To minimize the base concentration of a phase-transfer catalyst, [(18)F]fluoride was extracted from (18)O-enriched water trapped on an activated ion exchange cartridge (Chromafix PS-HCO(3)) using different concentrations of tetrabutylammonium bicarbonate (TBAHCO(3)) or Kryptofix 2.2.2./K(2)CO(3) in organic solvents such as CH(3)CN/H(2)O or MeOH/H(2)O. The optimal labeling condition for [(18)F]fallypride with automated synthesis was that 2 mg of tosyl-fallypride in acetonitrile (1 mL) was heated at 100 degrees C for 10 min using 40% TBAHCO(3) (10 microL). [(18)F]Fallypride was obtained with a high radiochemical yield of approximately 68+/-1.6% (decay-corrected, n=42) with a total synthesis time of 51+/-1.2 min, including HPLC purification and solid-phase purification for the final formulation.
Moon
Byung Seok
BS
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 463-707, Republic of Korea.
Park
Jun Hyung
JH
Lee
Hong Jin
HJ
Kim
Ji Sun
JS
Kil
Hee Sup
HS
Lee
Byoung Se
BS
Chi
Dae Yoon
DY
Lee
Byung Chul
BC
Kim
Yu Kyeong
YK
Kim
Sang Eun
SE
D002384:Catalysis; D005459:Fluorides / Q000737:chemistry*
D005459:Fluorides