Effect of maternal body mass index on in vitro response to tocolytics in term myometrium.
OBJECTIVE
We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics.


METHODS
Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI < or =29.9 (26.3 +/- 1.3; n = 7), 30-34.9 (31.8 +/- 1.2; n = 16), and > or = 35 (39.5 +/- 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10(-10) to 10(-5) mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test.


RESULTS
Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI.


CONCLUSIONS
BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.
Chiossi
Giuseppe
G
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Costantine
Maged M
MM
Betancourt
Ancizar
A
Hankins
Gary D V
GD
Longo
Monica
M
Saade
George R
GR
Bytautiene
Egle
E
D000328:Adult; D019540:Area Under Curve; D001706:Biopsy; D015992:Body Mass Index; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects / Q000473:pathology; D009543:Nifedipine / Q000494:pharmacology*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D015149:Tocolytic Agents; D009543:Nifedipine; D007213:Indomethacin