title: Speech disturbances in patients with dystonia or chorea due to neurometabolic disorders.
abstract: Speech disturbances are frequent and potentially disabling in patients with dystonia or chorea due to neurometabolic disorders (DCND), but their precise characteristics are poorly documented. We prospectively studied 29 consecutive patients with DCND. A detailed description of their speech patterns was obtained by using the Frenchay dysarthria assessment test and the apraxia of speech evaluation test of Wertz. Gross motor function and intelligibility were each scored on 5-point scales to identify a possible correlation between the severity of the speech and motor disorders. All the patients were found to have complex speech alterations with combined features of hyperkinetic dysarthria and speech apraxia. We also noted a correlation between the severity of the speech disorders and the motor disorders. These findings have important implications for speech rehabilitation, and may provide new insights into the pathophysiology of dystonia due to neurometabolic disorders.
authors.affiliation: Service de Neurologie, CHU de Bicêtre, AP-HP, Le Kremlin Bicêtre, France. constance.rouviere@bct.aphp.fr
authors.forename: Constance
authors.initials: C
authors.lastname: Flamand-Rouvière
authors.forename: Emilie
authors.initials: E
authors.lastname: Guettard
authors.forename: Caroline
authors.initials: C
authors.lastname: Moreau
authors.forename: Nadia
authors.initials: N
authors.lastname: Bahi-Buisson
authors.forename: Vassili
authors.initials: V
authors.lastname: Valayannopoulos
authors.forename: David
authors.initials: D
authors.lastname: Grabli
authors.forename: Jacques
authors.initials: J
authors.lastname: Motte
authors.forename: Diana
authors.initials: D
authors.lastname: Rodriguez
authors.forename: Agathe
authors.initials: A
authors.lastname: Roubertie
authors.forename: Lisa
authors.initials: L
authors.lastname: Maintigneux
authors.forename: Isabelle
authors.initials: I
authors.lastname: Kemlin
authors.forename: Irène
authors.initials: I
authors.lastname: Ceballos-Picot
authors.forename: David
authors.initials: D
authors.lastname: Adams
authors.forename: Marie
authors.initials: M
authors.lastname: Vidailhet
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roze
mesh_terms: D000293:Adolescent; D000328:Adult; D001928:Brain Diseases, Metabolic / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D002819:Chorea / Q000150:complications* / Q000209:etiology*; D004421:Dystonia / Q000150:complications* / Q000209:etiology*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination / Q000379:methods; D013064:Speech Disorders / Q000209:etiology*; D055815:Young Adult