title: A novel recurrent chromosomal aberration involving chromosome 7 in childhood myelodysplastic syndrome.
abstract: Monosomy 7 and/or deletion of the long arm of chromosome 7 is a common cytogenetic aberration in children with myelodysplastic syndrome (MDS) and is associated with poor outcome. In this report, we present an unusual cytogenetic abnormality leading to loss of both the whole short and whole long arms of chromosome 7, which was found in the bone marrow cells of three pediatric patients with MDS. Using a combination of conventional and molecular cytogenetic methods, a tiny "dot-like" marker chromosome was found and described as der(7)del(7)(p11)del(7)(q11). Together with one previously published case, this chromosomal aberration represents a new rare recurrent karyotypic abnormality involving chromosome 7 in children with MDS.
authors.affiliation: Center of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 2, Prague, Czech Republic.
authors.forename: Libuse
authors.initials: L
authors.lastname: Lizcova
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zemanova
authors.forename: Eva
authors.initials: E
authors.lastname: Malinova
authors.forename: Marie
authors.initials: M
authors.lastname: Jarosova
authors.forename: Ester
authors.initials: E
authors.lastname: Mejstrikova
authors.forename: Petr
authors.initials: P
authors.lastname: Smisek
authors.forename: Dagmar
authors.initials: D
authors.lastname: Pospisilova
authors.forename: Jan
authors.initials: J
authors.lastname: Stary
authors.forename: Kyra
authors.initials: K
authors.lastname: Michalova
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*