Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma.
In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. Some non-alcoholic compounds of beer, such as quercetin, resveratrol, ellagic acid or catechins, have been shown to be protective against experimentally induced pancreatitis by inhibiting pancreatic secretion, stellate cell activation or by reducing oxidative stress. Quercetin, ellagic acid and resveratrol also show anti-carcinogenic potential in vitro and in vivo. However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated.
Gerloff
Andreas
A
Department of Medicine II, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, Mannheim, Germany. andreas.gerloff@umm.de
Singer
Manfred V
MV
Feick
Peter
P
D001515:Beer / Q000032:analysis; D002392:Catechin / Q000494:pharmacology*; D004610:Ellagic Acid / Q000494:pharmacology*; D006801:Humans; D018384:Oxidative Stress; D010179:Pancreas / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000503:physiopathology*; D019512:Pancreatitis, Alcoholic / Q000503:physiopathology*; D011794:Quercetin / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D013267:Stilbenes; D004610:Ellagic Acid; D002392:Catechin; D011794:Quercetin; D000077185:Resveratrol