title: Laryngeal cancer involving a branchial cleft cyst.
abstract: BACKGROUND
  Benign secondary neck lesions in the setting of laryngeal cancer have been described, but not with branchial cleft cysts. This article describes a branchial cleft cyst in a laryngectomy/neck dissection specimen.
  
  
  RESULTS
  A 44-year-old woman presented to our emergency department with an obstructing laryngeal tumor that was staged as a T4N0M0 squamous cell cancer on the basis of clinical and radiographic findings. After laryngectomy with bilateral neck dissections, the neck specimen contained a right-sided branchial cleft cyst, which was directly invaded by tumor. In addition, the location of the cyst relative to the larynx suggested that this was a third branchial cleft cyst.
  
  
  CONCLUSIONS
  This is the first report of a laryngeal carcinoma invading a branchial cleft cyst. Staging discrepancies may result from concurrent head and neck lesions, altering treatment plans, or changing the prognosis for the patient. Lesions such as this are nearly impossible to diagnose preoperatively, and a high index of suspicion for advanced cancer should be maintained.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio, USA. jonathan.ida@cchmc.org
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Ida
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Stark
authors.forename: Zhenggong
authors.initials: Z
authors.lastname: Xiang
authors.forename: Mary M
authors.initials: MM
authors.lastname: Fazekas-May
mesh_terms: D000328:Adult; D001935:Branchioma / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy; D037981:Neck Dissection; D009378:Neoplasms, Multiple Primary / Q000473:pathology*