A rare case of acute lymphoblastic leukemia with t(12;17)(p13;q21).
Patients with ALL rarely present with t(12;17)(p13;q21) as the primary clonal abnormality; this abnormality is associated with the expression of myeloid antigens. In this study, we have reported presumably the first case of this chromosomal abnormality in Korea, thereby facilitating the delineation of a distinct subtype of ALL. A 57-yr-old woman was referred to our hospital because of pancytopenia. Peripheral blood examination showed 55% blasts. The bone marrow was markedly hypercellular, and about 82.4% of all nucleated cells were blasts. The results of immunophenotyping and cytochemical staining suggested early precursor B-ALL. Cytogenetic analysis of the bone marrow cells showed a complex karyotype, including a reciprocal translocation between the short arm of chromosome 12 and the long arm of chromosome 17, t(12;17)(p13;q21). Data from array comparative genomic hybridization were almost consistent with the cytogenetic findings.
Kim
Ji Eun
JE
Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea.
Woo
Kwang Sook
KS
Kim
Kyung Eun
KE
Kim
Sung Hyun
SH
Park
Joo In
JI
Shaffer
Lisa G
LG
Han
Jin Yeong
JY
D001853:Bone Marrow / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008875:Middle Aged; D010198:Pancytopenia / Q000150:complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic