title: A video Clinical Global Impression (CGI) in obsessive compulsive disorder.
abstract: The Clinical Global Impression scale (CGI) is frequently used in clinical research because of its face validity and ease of use but data on its reliability are scarce. Our goal was to estimate the reliability of the scale and compare reliability between face-to-face and video scoring. We analyzed 50 different video interviews recorded during 5 visits of a crossover trial to study the effect of subthalamic nucleus stimulation. Six specialized clinicians rated the CGI using these videos, providing 300 different ratings. The intraclass correlation was lower at inclusion (0.30 [0.13-0.50]) than at later visits (0.68 [0.61-0.80]). Reliability was not influenced by the patients' stimulation status. The mean of at least two independent evaluations of the video is needed to achieve an ICC greater than 0.8. The video CGI is a valid clinical outcome measure suitable for clinical trials (ClinicalTrials.gov number, NCT00169377).
authors.affiliation: Pierre and Marie Curie Paris 6 University, ER4, Modelling in Clinical Research, Paris, France.
authors.forename: Abderrahmane
authors.initials: A
authors.lastname: Bourredjem
authors.forename: Antoine
authors.initials: A
authors.lastname: Pelissolo
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Rotge
authors.forename: Nematollah
authors.initials: N
authors.lastname: Jaafari
authors.forename: Sebastien
authors.initials: S
authors.lastname: Machefaux
authors.forename: Solene
authors.initials: S
authors.lastname: Quentin
authors.forename: Eric
authors.initials: E
authors.lastname: Bui
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bruno
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Pochon
authors.forename: Mircea
authors.initials: M
authors.lastname: Polosan
authors.forename: Nicolas
authors.initials: N
authors.lastname: Baup
authors.forename: François
authors.initials: F
authors.lastname: Papetti
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chéreau
authors.forename: Christophe
authors.initials: C
authors.lastname: Arbus
authors.forename: Luc
authors.initials: L
authors.lastname: Mallet
authors.forename: Sophie Tezenas
authors.initials: ST
authors.lastname: du Montcel
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D046690:Deep Brain Stimulation / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000628:therapy; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000502:physiology; D013997:Time Factors; D014741:Video Recording / Q000379:methods*