title: Significant decrease in glomerular filtration rate at 5 years posttransplantation in the recipients of live donor kidneys 50 years of age or older.
abstract: BACKGROUND
  Age is an established predictor of renal failure among recipients of cadaveric transplants; however, the impact of donor age on recipient glomerular filtration rate (GFR) among living donor kidney (LDK) transplantations is not well established.
  
  
  METHODS
  We retrospectively analyzed recipient posttransplantation GFR at 12, 36, and 60 months among 315 LDK allograft recipients. The impact of donor age was assessed on the recipient estimated GFR (eGFR) using multivariate linear regression stratified according to donor age <50 years (n = 246) and >or=50 years (n = 69).
  
  
  RESULTS
  Whites comprised the majority of both donors and recipients (77%). The majority (58.4%) of donors were female. Mean age (+/- SD) of the donors was 41.0 +/- 10.2 years (range, 20-65 years). The mean age and body mass index (BMI) of the recipients were 43.3 +/- 12.4 years and 26.0 +/- 4.9, respectively. There was no statistically significant difference in the rejection rate between the 2 groups (P = .571). Mean eGFR at 12 months in the younger group was 63.3 +/- 23.7 compared with 54.8 +/- 19.7 in the older group (P = .015). Similarly, a significant difference was observed at the end of 36 months and 60 months of follow-up (61.5 +/- 23.1 vs 49.4 +/- 18.9, and 59.4 +/- 23.0 vs 45.3 +/- 20.8, respectively; both P = .001). Donor age was a statistically significant predictor of eGFR throughout the study period (P < .05).
  
  
  CONCLUSIONS
  Donor age predicts recipient renal function after living kidney transplantation and needs to be evaluated through a larger prospective investigation.
authors.affiliation: Department of Transplant Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA.
authors.forename: N
authors.initials: N
authors.lastname: Jain
authors.forename: M
authors.initials: M
authors.lastname: Airy
authors.forename: P
authors.initials: P
authors.lastname: Kumari
authors.forename: D
authors.initials: D
authors.lastname: Hull
authors.forename: K V
authors.initials: KV
authors.lastname: Ranga
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology / Q000401:mortality / Q000706:statistics & numerical data*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D051437:Renal Insufficiency / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents