High levels of serum angiogenic growth factors in patients with AL amyloidosis: comparisons with normal individuals and multiple myeloma patients.
Serum levels of five angiogenic cytokines were evaluated in 82 patients with primary systemic amyloidosis (AL). Angiopoietin-1, vascular endothelial growth factor, basic fibroblast growth factor and angiogenin were higher in AL patients than in controls (n = 35) and newly-diagnosed, symptomatic, myeloma patients (n = 35). Angiopoetin-1/Angiopoetin-2 ratio was lower in AL compared to controls but higher than in myeloma patients. Angiopoetin-2 correlated with cardiac dysfunction indices; however, none of the angiogenic growth factors was prognostically significant. The increased angiogenic cytokine levels observed in AL seem to represent either a toxic effect of amyloid fibrils or light chains, or a compensatory response to organ dysfunction.
Kastritis
Efstathios
E
Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece. ekastritis@gmail.com
Roussou
Maria
M
Michael
Michalis
M
Gavriatopoulou
Maria
M
Michalis
Evridiki
E
Migkou
Magdalini
M
Delimpasi
Sossana
S
Kyrtsonis
Marie Christine
MC
Gogos
Dimitrios
D
Liapis
Konstantinos
K
Charitaki
Evangelia
E
Repousis
Panagiotis
P
Terpos
Evangelos
E
Dimopoulos
Meletios A
MA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000097:blood*; D042501:Angiogenic Proteins / Q000097:blood*; D042683:Angiopoietin-1 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D009363:Neoplasm Proteins / Q000097:blood; D012259:Ribonuclease, Pancreatic / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D042501:Angiogenic Proteins; D042683:Angiopoietin-1; D015415:Biomarkers; D009363:Neoplasm Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; C046366:angiogenin; D012259:Ribonuclease, Pancreatic