title: NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose.
abstract: The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)-biotin starting from D-mannose as chiral pool were completely assigned using one- and two-dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC.
authors.forename: Wen-Xue
authors.initials: WX
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Fen-er
authors.initials: FE
authors.lastname: Chen
mesh_terms: D001710:Biotin / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008358:Mannose / Q000737:chemistry*; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D001710:Biotin; D008358:Mannose