Disposition of marbofloxacin in vulture (Gyps fulvus) after intravenous administration of a single dose.
The pharmacokinetics properties of marbofloxacin were studied in adult Eurassian Griffon vulture after single-dose intravenous (IV) administration of 2mg/kg. Drug concentration in plasma was determined by high-performance liquid chromatography and the data obtained were subjected to compartmental and non-compartmental kinetic analysis. Marbofloxacin presented a volume of distribution at steady-state (Vdss) of 1.51±0.22L and total plasma clearance (Cl) of 0.109±0.023L/hkg. The permanence of this drug was long in vultures (T(1/2)(λ)=12.51±2.52h; MRT(∞)=13.54±2.29h). The optimal dose of marbofloxacin estimated is 2.73mg/kg per day for the treatment of infections in vultures with MIC(90)=0.2μg/mL.
Garcia-Montijano
Marino
M
Hospital de Rapaces Altai, Torrelaguna, Madrid, Spain.
Waxman
Samanta
S
de Lucas
J Julio
JJ
Luaces
I
I
de San Andrés
María Dolores
MD
Rodríguez
Casilda
C
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D046093:Falconiformes / Q000097:blood*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C080260:marbofloxacin