Detection of aortic regurgitation with 64-slice multidetector computed tomography (MDCT).
OBJECTIVE
To determine the diagnostic accuracy of 64-row multidetector cardiac computed tomography (MDCT) in detecting aortic regurgitation (AR) on prospectively acquired images with trans-thoracic echocardiography (TTE) as a reference standard.


METHODS
Forty-three consecutive patients underwent MDCT and TTE. AR was defined on MDCT images acquired at 75% phase of R-R interval as the lack of aortic cusps coaptation. The maximum regurgitant orifice area (ROA) was planimetered and compared to TTE.


RESULTS
All 29 patients with AR on TTE were correctly identified by MDCT. The sensitivity, specificity, positive predictive value, and negative predictive value of MDCT were 100%, 85.7%, 93.5%, and 100%, respectively. Sixteen, nine, and four patients were found to have mild, moderate, and severe AR on TTE, respectively. The corresponding ROA by MDCT were 3.25 +/- 1.04 mm(2), 4.16 +/- 1.19 mm(2), and 11.30 +/- 6.13 mm(2), respectively.


CONCLUSIONS
MDCT data acquired for the coronary artery evaluation can be used for the detection of aortic regurgitation with high diagnostic accuracy without additional scanning or radiation and can support appropriate referral for TTE.
Zeb
Irfan
I
Division of Cardiology Los Angeles Biomedical Research Institute Harbor-UCLA, Torrance, CA, USA.
Hamirani
Yasmin S
YS
Mao
Songshuo
S
Isma'eel
Hussain
H
Saeed
Anila
A
Karnwal
Sudha
S
Raina
Sameer
S
Chung
Jina
J
Budoff
Matthew J
MJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography