Osseointegration of titanium implants with a roughened surface containing hydride ion in a rabbit model.
OBJECTIVE
The objective of this study was to investigate the effect of hydride ion on bone formation and bone-bonding strength at the early stage of implantation.


METHODS
Implants and plates were treated in 2 ways: test implant (implant surface with hydride ion) and control implant (implant surface without hydride ion). Crystal structure of plate surfaces was analyzed by low angle x-ray diffractometry (XRD). Sixty implants (30 test implants and 30 control implants) were inserted into tibias of 10 rabbits. At 2 and 8 weeks postimplantation, tibias were retrieved and prepared for removal torque tests (RTQ) and histomorphometric evaluation, respectively.


RESULTS
TiH(2) diffractions appeared on the XRD pattern of the test surface whereas TiH(2) did not appear on the control surface. The test implants showed 51.28% and 64.63% greater RTQ values than did the control implants at 2 and 8 weeks (P = .010, .011, respectively). Histomorphometric evaluation demonstrated the test implants significantly increased bone-implant contact and peri-implant bone formation at 2 and 8 weeks.


CONCLUSIONS
These results suggest the presence of hydride ion in the implant surface may improve bone integration with implant surfaces at the early stage of implantation.
Cheng
Zhipeng
Z
Department of Implantology, Stomatology Hospital, School of Medical, Zhejiang University, Hangzhou, China.
Zhang
Feng
F
He
Fuming
F
Zhang
Lijuan
L
Guo
Caihong
C
Zhao
Shifang
S
Yang
Guoli
G
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D003461:Crystallography; D045662:Dental Etching; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D003775:Dental Polishing; D017267:Dental Prosthesis Design; D006851:Hydrochloric Acid / Q000737:chemistry; D006858:Hydrofluoric Acid / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D017942:Nitric Acid / Q000737:chemistry; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D011817:Rabbits; D033081:Shear Strength; D013314:Stress, Mechanical; D013464:Sulfuric Acids / Q000737:chemistry; D013499:Surface Properties; D013977:Tibia / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D019415:Torque; D014961:X-Ray Diffraction
D015921:Dental Implants; D003764:Dental Materials; D013464:Sulfuric Acids; D017942:Nitric Acid; D006859:Hydrogen; D014025:Titanium; C033158:sulfuric acid; D006851:Hydrochloric Acid; D006858:Hydrofluoric Acid