Level of evidence for therapeutic drug monitoring for etoposide after oral administration.
Oral etoposide displays high intervariability and intravariability. Convincing relationships were observed between hematological toxicities and exposure of which total etoposide area under the curve seems the more relevant in routine practice. Linear pharmacokinetics, limited sampling strategies and reduction in variability during concentration-controlled studies argue in favor of therapeutic drug monitoring. However, such reduction in variability should be confirmed after oral administration. For these reasons, such practice can be considered as 'potentially useful'. Further studies using Bayesian approach are nevertheless needed to definitely state regarding the level of evidence therapeutic drug monitoring of oral etoposide.
Gerritsen-van Schieveen
Pauline
P
CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon 25030, France.
Royer
Bernard
B
D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001499:Bayes Theorem; D001682:Biological Availability; D016903:Drug Monitoring / Q000379:methods*; D005047:Etoposide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans
D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide