title: Sepsis in burns: a review of current practice and future therapies.
abstract: Sepsis is a major cause of death worldwide and remains the subject of much research and debate within the critical care community. Despite advances in burn prevention, treatment, and rehabilitation, sepsis remains a common cause of death in patients who have sustained a severe burn injury. The unique physical, metabolic, and physiologic changes seen after major thermal injury mean that the management of sepsis in burns poses a particular challenge and differs in many respects to the management of sepsis in the general critical care population. This article describes current issues in the prevention, diagnosis, and treatment of sepsis in burns with a review of the associated literature. In addition, we discuss possible future therapies for managing this condition.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University Hospital North Staffordshire, Stoke on Trent, United Kingdom. elizabeth_chipp@hotmail.com
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Chipp
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Milner
authors.forename: Adam V
authors.initials: AV
authors.lastname: Blackburn
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D001458:Bandages; D015415:Biomarkers / Q000032:analysis; D002056:Burns / Q000150:complications*; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003666:Decontamination; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D011486:Protein C / Q000627:therapeutic use; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D007328:Insulin; D011486:Protein C