title: Statin for prevention of atrial fibrillation after off-pump coronary artery bypass grafting in Japanese patients.
abstract: BACKGROUND
  The purpose of the present study was to assess the preventive effect of preoperative statin treatment on atrial fibrillation (AF) after elective isolated off-pump coronary artery bypass grafting (off-pump CABG) in propensity score-matched Japanese patients.
  
  
  RESULTS
  Among 770 consecutive patients undergoing isolated CABG by the same surgeon (99.2% with off-pump technique without conversion to cardiopulmonary bypass) between 2002 and 2009, after excluding emergency (n=150), chronic AF (n=30), and use of cardiopulmonary bypass (n=6), 584 patients were retrospectively reviewed. Of this cohort, 364 patients received statin at least 5 days before operation and 220 patients received no statin. We identified 195 propensity score-matched pairs. Propensity scores were created based on 8 preoperative factors (C statistics, 0.69). There was no significant difference between the 2 groups in baseline characteristics, perioperative medications, or operative procedures. AF occurred in 14.4% in the statin group and in 24.6% in the no statin group (P=0.01). Multivariate logistic regression including potential univariate predictors identified statin (odds ratio [OR] =0.49; 95% confidence interval [95%CI] =0.22-0.81; P=0.01), age (OR =1.33 per 10-year increase; 95%CI =1.04-1.69; P=0.02), and transfusion (OR =2.21; 95%CI =1.38-3.55; P=0.01) as independent predictors of postoperative AF.
  
  
  CONCLUSIONS
  Preoperative statin significantly reduces the incidence of AF after elective isolated off-pump CABG in Japanese patients.
authors.affiliation: Division of Cardiovascular Surgery, Shiga University of Medical Science, Otsu, Japan. kinotakekinotake@yahoo.co.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Tohru
authors.initials: T
authors.lastname: Asai
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishimura
authors.forename: Norihiko
authors.initials: N
authors.lastname: Hiramatsu
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kambara
authors.forename: Keiji
authors.initials: K
authors.lastname: Matsubayashi
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000517:prevention & control*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D011292:Premedication / Q000379:methods*; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors