title: Biotransformation of bioactive (-)-mellein by a marine isolate of bacterium Stappia sp.
abstract: The biological transformation of the bioactive dihydroisocoumarin, (-)-mellein, isolated from the marine-derived fungus Cladosporium sp., was studied. The preparative-scale culture of (-)-mellein with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein. The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.
authors.affiliation: Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
authors.forename: Zhile
authors.initials: Z
authors.lastname: Feng
authors.forename: Viviane
authors.initials: V
authors.lastname: Nenkep
authors.forename: Keumja
authors.initials: K
authors.lastname: Yun
authors.forename: Dahai
authors.initials: D
authors.lastname: Zhang
authors.forename: Hong Dae
authors.initials: HD
authors.lastname: Choi
authors.forename: Jung Sook
authors.initials: JS
authors.lastname: Kang
authors.forename: Byeng Wha
authors.initials: BW
authors.lastname: Son
mesh_terms: D001711:Biotransformation; D002963:Cladosporium / Q000378:metabolism*; D009793:Ochratoxins / Q000737:chemistry / Q000378:metabolism*; D041902:Rhodobacteraceae / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D012623:Seawater / Q000382:microbiology*; D013237:Stereoisomerism
chemical_list: D009793:Ochratoxins; C120538:ochracin