title: Synthesis and antimicrobial activity of some novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines.
abstract: A new series of novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines 5a-d and 4-(1H-benz[d]imidazol-2yl)-3-alkyl-2,3-dihydro-1,3-thiazol-2-amine 8a-d has been synthesized by the cyclocondensation of 2-acetyl benzimidiazoles 4a-d and 2-bromo-1-(1-alkyl-1H-benzo[d]imidazol-2-yl)-1-ethanone 7a-d with thiourea respectively, and evaluated for their antibacterial and antifungal activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in these series exhibited antibacterial activity comparable to standard Streptomycin and Benzyl penicillin and antifungal activity against Fluconazole. All the newly synthesized compounds were characterized by their spectral data and further used to estimate their ability towards antimicrobial activity.
authors.affiliation: Dr. Ch. Ravishanker Memorial Medicinal Chemistry Research Laboratory, College of Pharmaceutical Sciences, Kakatiya University, Warangal, India. vanga_mreddy@rediffmail.com
authors.forename: Vanga
authors.initials: V
authors.lastname: Malla Reddy
authors.forename: Kunduru
authors.initials: K
authors.lastname: Ravinder Reddy
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D013890:Thiourea