title: [Shy-Drager syndrome].
abstract: Shy-Drager syndrome is a rare neurological disease with a poor prognosis causing a generalised autonomy dysfunction. The disorder is also known as multiple system atrophy, the orthostatic hypotension syndrome or Shy-McGee-Drager syndrome. Patients have mainly dysautonomic symptoms. Patients suffer from orthostatic hypotension, bradycardia, anhidrosis, failure of accommodation, sialoporia, low tears secretion, gastrointestinal dysmotility and incomplete emptying of the urinary bladder. Neuropathological examination of patient's brains demonstrated neurodegenerative changes of the structures of central nervous system, mainly of brainstem. The Shy-Drager syndrome results from striatonigral and olivo-ponto-cerebellar atrophy and from accumulation of alpha-synuclein in these structures. The patients suffering from the Shy-Drager syndrome are very often misdiagnosed because of overlap of symptomatology with psychiatric and psychosomatic diseases. It is also very difficult to make the diagnosis because of complexity of symptoms. The prognosis of Shy-Drager syndrome is very poor; patients are markedly disabled and have shorter survival.
authors.affiliation: Univerzita Karlova v Praze, 1. lékarská fakulta, IV. interní klinika VFN.
authors.forename: Magdaléna
authors.initials: M
authors.lastname: Dusejovská
authors.forename: Tomás
authors.initials: T
authors.lastname: Vareka
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Macásek
authors.forename: Karel
authors.initials: K
authors.lastname: Hrubant
authors.forename: Ales
authors.initials: A
authors.lastname: Zák
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zeman
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D012791:Shy-Drager Syndrome / Q000175:diagnosis