title: [Theoretical and experimental studies on apparent solubility parameters of multiple components for Chinese materia medica with HPLC fingerprint].
abstract: OBJECTIVE
  To establish the theories and methods to determine apparent solubility paraneters of multiple components for the Chinese materia medica (CMM) with HPLC fingerprint.
  
  
  METHODS
  The mathematical functional expresses to determine the apparent solubility parameters for multiple constituents were established according to total quantum geometrical average retention time (TQGART) for HPLC fingerprint that characterized the entirety tendencies for all-over chromatographic peaks, validated by the aloe-emodin's solubility parameters which had been determined. The HPLC for the aloe-emodin's solubility parameters were carried out with an Alltech Apollo C18 as column, Acetone: Water as mobile phase, gradient elution,flow rate as 1.0 mL x min(-1), the detection wave-length as 430 nm and the temperature as 30 degrees C.
  
  
  RESULTS
  The mathematical functional model between the TQGART of HPLC chromatographic fingerprint and the total quantum apparent solubility parameters was established and used to determine the aloe-emodin's mixture solubility parameter as 36.12 J(1/2) x cm(-3/2), nearly equal to 35.57, 36.07 J(1/2) x cm(-3/2) calculated by ration of peak area ratios and molecular fraction, respectively.
  
  
  CONCLUSIONS
  The TQGART of HPLC fingerprint can be used to determine simultaneously the apparent or single intrinsic solubility parameters for total quantum or intrinsic solubility parameters for single in multiple constitute systems, by which theoretical and technologic platform to study the compatibility rule and dosage form reform of the single CMM will be established.
authors.affiliation: Department of Pharmaceutics, Hunan University of Tradition Chinese Medicine, Changsha 410208, China. pharmsharking@tom.com
authors.forename: Fuyuan
authors.initials: F
authors.lastname: He
authors.forename: Wenlong
authors.initials: W
authors.lastname: Liu
authors.forename: Jin
authors.initials: J
authors.lastname: Fu
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Deng
authors.forename: Dezhi
authors.initials: D
authors.lastname: Wu
authors.forename: Ruwen
authors.initials: R
authors.lastname: Dai
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Pi
authors.forename: Jieying
authors.initials: J
authors.lastname: Luo
authors.forename: Honghao
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000880:Anthraquinones / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000706:statistics & numerical data*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008962:Models, Theoretical; D012995:Solubility
chemical_list: D000880:Anthraquinones; D004365:Drugs, Chinese Herbal; C518327:aloe emodin