title: Investigation of bone formation using calcium phosphate glass cement in beagle dogs.
abstract: OBJECTIVE
  Among available biomaterials, bioceramics have drawn special interest due to their bioactivity and the possibility of tailoring their composition. The degradation rate and formulation of bioceramics can be altered to mimic the compositions of the mineral phase of bone. The aim of this study was to investigate the bone formation effect of amorphous calcium phosphate glass cement (CPGC) synthesized by a melting and quenching process.
  
  
  METHODS
  In five male beagle dogs, 4 x 4 mm 1-wall intrabony defects were created bilaterally at the mesial or distal aspect of the mandibular second and fourth premolars. Each of the four defects was divided according to graft materials: CPGC with collagen membrane (CM), biphasic calcium phosphate (BCP) with CM, CM alone, or a surgical flap operation only. The dogs were sacrificed 8 weeks post-surgery, and block sections of the defects were collected for histologic and histometric analysis.
  
  
  RESULTS
  There were significant differences in bone formation and cementum regeneration between the experimental and control groups. In particular, the CPGC and BCP groups showed greater bone formation than the CM and control groups.
  
  
  CONCLUSIONS
  In conclusion, CPGC was replaced rapidly with an abundant volume of new bone; CPGC also contributed slightly to regeneration of the periodontal apparatus.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: Seung-Bum
authors.initials: SB
authors.lastname: Lee
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
authors.forename: Youna
authors.initials: Y
authors.lastname: Choi
authors.forename: Otgonbold
authors.initials: O
authors.lastname: Jamiyandorj
authors.forename: Chang-Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Yong-Keun
authors.initials: YK
authors.lastname: Lee
authors.forename: Jung-Kiu
authors.initials: JK
authors.lastname: Chai
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi