Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue.
We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.
Bell
Diana
D
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Zhao
Yi-Jue
YJ
Rao
Pulivarthi H
PH
Weber
Randal S
RS
El-Naggar
Adel K
AK
D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D008297:Male; D008875:Middle Aged; D010614:Pharynx / Q000469:parasitology / Q000601:surgery; D032681:Spectral Karyotyping; D014062:Tongue Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014178:Translocation, Genetic; D016896:Treatment Outcome