title: Severe cutaneous adverse reactions: acute generalized exanthematous pustulosis, toxic epidermal necrolysis and Stevens-Johnson syndrome.
abstract: Most drug hypersensitivity reactions show skin symptoms. The most severe cutaneous manifestations include pustular and bullous skin eruptions. These 2 manifestations can lead to acute generalized exanthematous pustulosis or Stevens-Johnson syndrome and toxic epidermal necrolysis. These complications are rare, but should be known to any doctor prescribing drugs because they are life threatening and early stoppage of treatment is mandatory.
authors.affiliation: Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, Zurich 8031, Switzerland. thomas.harr@usz.ch
authors.forename: Thomas
authors.initials: T
authors.lastname: Harr
authors.forename: Lars E
authors.initials: LE
authors.lastname: French
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D055553:Prescription Drugs / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D055553:Prescription Drugs