Clinical utility of genotypic resistance tests for HIV-1-infected patients with low-level virological failure.
The usefulness of genotypic resistance tests (GRT) among HIV-1 patients with low-level virological failure (LLVF) was evaluated. Up to 78% of samples with <1,000 copies/ml were sequenced successfully. For samples with 50 to 200 copies/ml, the success rate was as high as 69%. LLVF should not deter clinicians from requesting GRT.
Elgalib
A
A
Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Perry
M
M
Aboud
M
M
Mullen
J
J
O'Shea
S
S
Chrystie
I L
IL
Kulasegaram
R
R
Tong
C Y W
CY
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D020125:Mutation, Missense; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral