title: A case of IgG4-related lung disease associated with multicentric Castleman's disease and lung cancer.
abstract: A 67-year-old man with submaxillary lymphadenopathy diagnosed as reactive follicular hyperplasia of the lymph node was referred to us for pulmonary evaluation. Pathological findings of the lung and hilar lymph node biopsies showed the histological feature of Castleman's disease (CD). Interestingly, infiltrated plasma cells had strong immunoreactivity for IgG4. In addition, this patient had coexisting lung cancer. We believe this is the first described case of IgG4-related lung disease associated with multicentric CD (MCD) and lung cancer. To establish a therapeutic strategy for IgG4-related lung disease, the association between IgG4-related disease and MCD needs to be clarified.
authors.affiliation: Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu. junijunieight@yahoo.co.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Ikari
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tomita
authors.forename: Toru
authors.initials: T
authors.lastname: Nakamura
authors.forename: Futoru
authors.initials: F
authors.lastname: Toyoda
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Otsuki
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000175:diagnosis* / Q000453:epidemiology; D015897:Comorbidity; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008171:Lung Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G