title: Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
abstract: Antimicrobial susceptibilities of 233 gram-positive and 180 gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 microg/ml. One bis-indole, MBX 1162, exhibited potent activity against all gram-negative strains, with MIC(90) values of 0.12 to 4 microg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.
authors.affiliation: Microbiotix, Inc., One Innovation Drive, Worcester, MA 01605, USA. mbutler@microbiotix.com
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Butler
authors.forename: John D
authors.initials: JD
authors.lastname: Williams
authors.forename: Norton P
authors.initials: NP
authors.lastname: Peet
authors.forename: Donald T
authors.initials: DT
authors.lastname: Moir
authors.forename: Rekha G
authors.initials: RG
authors.lastname: Panchal
authors.forename: Sina
authors.initials: S
authors.lastname: Bavari
authors.forename: Dean L
authors.initials: DL
authors.lastname: Shinabarger
authors.forename: Terry L
authors.initials: TL
authors.lastname: Bowlin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; C030374:indole