title: Hybrid nanomaterials for biomedical applications.
abstract: Hybrid nanomaterials, composed of both inorganic and organic components, have recently been examined as promising platforms for imaging and therapeutic applications. This unique class of nanomaterials can not only retain beneficial features of both the inorganic and organic components, but also provides the ability to systematically tune the properties of the hybrid material through the combination of functional components. This feature article will summarize recent advances in the design and synthesis of hybrid nanomaterials and their applications in biological and biomedical areas. The hybrid nanomaterials to be discussed fall into two main categories, silica based materials and nanoscale metal-organic frameworks. Their applications as imaging contrast agents and nanotherapeutics will be highlighted.
authors.affiliation: Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Kathryn M L
authors.initials: KM
authors.lastname: Taylor-Pashow
authors.forename: Joseph
authors.initials: J
authors.lastname: Della Rocca
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Huxford
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008670:Metals / Q000737:chemistry; D051379:Mice; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes; D008670:Metals; D012822:Silicon Dioxide