Matrix metalloproteinase-9 contributes to the increase of tau protein in serum during acute ischemic stroke.
Previous studies indicate that tau protein, a marker of damage to neurons, is present in the serum of healthy patients at a concentration approximately 40 percent that of patients with ischemic stroke We assumed that increased serum activity of gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9) can influence the level of tau protein in serum, probably due to disruption of the blood-brain barrier. We obtained blood sera from 31 patients admitted within the first 24 hours of ischemic stroke on days 1, 5 and 10, following the onset of stroke. Tau protein was detected in the serum of 12 patients (38.7 percent). The highest MMP-9 activity was recorded on day 5 (p < 0.05). Serum gelatinase activity did not differ between tau protein-positive or -negative individuals. However, a high degree of correlation between mean MMP-9 activity and the maximum tau protein level was observed for patients with detectable tau protein (r = 0.71, p = 0.009). Our study suggests that MMP-9 can increase the tau protein level in the sera of patients during acute ischemic stroke.
Kurzepa
Jacek
J
Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland. kurzepa@onet.pl
Bielewicz
Joanna
J
Grabarska
Aneta
A
Stelmasiak
Zbigniew
Z
Stryjecka-Zimmer
Marta
M
Bartosik-Psujek
Halina
H
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002545:Brain Ischemia / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D018579:Patient Selection; D020521:Stroke / Q000097:blood*; D013997:Time Factors; D016875:tau Proteins / Q000097:blood*
D016875:tau Proteins; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9