title: Diagnostic exercise. Cerebral mass in a puppy with respiratory distress and progressive neurologic signs.
abstract: A 5-month-old mongrel puppy with a history of respiratory disease presented with progressive neurologic dysfunction. Hematologic results included leukocytosis (neutrophilia with a left shift) and lymphopenia. A mass in the right forebrain, identified by magnetic resonance imaging, was biopsied during decompressive craniectomy. The histologic diagnosis was granulomatous meningoencephalitis with intralesional amoebae. The dog died within 24 hours of surgery. At necropsy, a well-demarcated granuloma was confined to the cerebrum, but granulomatous pneumonia was disseminated through all lobes of the lung. Concurrent infections included canine distemper, canine adenoviral bronchiolitis, and oral candidiasis. Canine distemper virus probably caused immunosuppression and increased susceptibility to secondary infections.
authors.affiliation: Purdue University, Animal Disease Diagnostic Laboratory, 406 S. University St., West Lafayette, IN 47907 Email: lreed@purdue.edu.
authors.forename: L T
authors.initials: LT
authors.lastname: Reed
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
authors.forename: G S
authors.initials: GS
authors.lastname: Visvesvara
authors.forename: C H
authors.initials: CH
authors.lastname: Gardiner
authors.forename: M A
authors.initials: MA
authors.lastname: Logan
authors.forename: R A
authors.initials: RA
authors.lastname: Packer
mesh_terms: D048248:Acanthamoeba castellanii; D000562:Amebiasis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001921:Brain / Q000469:parasitology / Q000473:pathology; D020808:Central Nervous System Protozoal Infections / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012128:Respiratory Distress Syndrome / Q000469:parasitology / Q000662:veterinary