Nomenclature of monocytes and dendritic cells in blood.
Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense. Over recent years these cells have been characterized in detail with the use of cell surface markers and flow cytometry, and subpopulations have been described. The present document proposes a nomenclature for these cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood. This classification has been approved by the Nomenclature Committee of the International Union of Immunological Societies, and we are convinced that it will facilitate communication among experts and in the wider scientific community.
Ziegler-Heitbrock
Loems
L
Helmholtz Zentrum München, Gauting, Germany. ziegler-heitbrock@helmholtz-muenchen.de
Ancuta
Petronela
P
Crowe
Suzanne
S
Dalod
Marc
M
Grau
Veronika
V
Hart
Derek N
DN
Leenen
Pieter J M
PJ
Liu
Yong-Jun
YJ
MacPherson
Gordon
G
Randolph
Gwendalyn J
GJ
Scherberich
Juergen
J
Schmitz
Juergen
J
Shortman
Ken
K
Sozzani
Silvano
S
Strobl
Herbert
H
Zembala
Marek
M
Austyn
Jonathan M
JM
Lutz
Manfred B
MB
D000818:Animals; D001773:Blood Cells / Q000145:classification*; D003713:Dendritic Cells / Q000145:classification*; D006801:Humans; D051379:Mice; D009000:Monocytes / Q000145:classification*; D009626:Terminology as Topic