Use of in vivo insert molding to form a jellyfish valve leaflet.
We developed an in vivo insert molding technique to form tissue-derived biomaterials into the desired shape, and with sufficient strength and durability, for use in artificial organs. Molds of acrylic resin with inserted velour cloth were implanted under the skin of goats to form a circular leaflet for a jellyfish valve. The valve leaflets were successfully produced in the molds after 17-60 days. Dense connective tissue covered the velour cloth, and loose connective tissue was formed within it. Tissue was radially formed from the hole in the mold. The tissue was simultaneously formed and shrunk. It is necessary to increase the connected portion between the tissue inside and outside the mold so that the tissue can completely cover the inserted materials without shrinkage.
Kishi
Ayumi
A
Kitasato University, Kanagawa, Japan. mm07021s@kitasato-u.ac.jp
Isoyama
Takashi
T
Saito
Itsuro
I
Miura
Hidekazu
H
Nakagawa
Hidemoto
H
Kouno
Akimasa
A
Ono
Toshiya
T
Inoue
Yusuke
Y
Yamaguchi
Sachiko
S
Shi
Wei
W
Abe
Yusuke
Y
Imachi
Kou
K
Noshiro
Makoto
M
D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001705:Bioprosthesis; D006041:Goats; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006351:Heart Valves / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry
D000180:Acrylic Resins; D001672:Biocompatible Materials; D011091:Polyesters; C020542:velour