title: New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems.
abstract: A new synthetic method providing expedient access to a wide range of polyfunctionalized N-hydroxyindoles (IV) is reported. These unique constructs are assembled by nucleophilic additions to in situ generated α,β-unsaturated nitrones (III) through carbon-carbon and carbon-heteroatom bond formation. The new synthetic technology was applied to the synthesis of nocathiacin I (1) model systems (2 and 3a-c) containing the N-hydroxyindole structural motif.
authors.affiliation: Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, and Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093.
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Estrada
authors.forename: Graeme C
authors.initials: GC
authors.lastname: Freestone
authors.forename: Sang Hyup
authors.initials: SH
authors.lastname: Lee
authors.forename: Xavier
authors.initials: X
authors.lastname: Alvarez-Mico