[Purpura fulminans].
Varicella-associated purpura fulminans (PF) is a rare complication to varicella infection. The condition is due to autoantibodies directed against protein S which forms part of the anticoagulation system. Lack of protein S leads to disseminated intravascular coagulation in the small vessels, which causes thrombosis and ischemia. Despite early treatment, amputation and skin-grafting is often necessary. In this case story, we give a brief review of the pathogenesis and possible modes of treatment. Knowledge of PF is necessary since early treatment may be life-saving.
Jordan
Karina
K
Paediatrisk Klinik, Rigshospitalet, 2100 København Ø. jordan.karina@gmail.com
Kristensen
Kim
K
D001323:Autoantibodies / Q000097:blood; D002644:Chickenpox / Q000150:complications / Q000276:immunology; D002675:Child, Preschool; D006801:Humans; D008297:Male; D018455:Protein S Deficiency / Q000150:complications / Q000276:immunology; D055665:Purpura Fulminans / Q000276:immunology / Q000628:therapy / Q000821:virology
D001323:Autoantibodies