Is tetrachloroethylene genotoxic or not?
A recent study published in Mutagenesis, in which the ability of tetrachloroethylene to induce DNA damage, detected by the alkaline comet assay, in mouse tissues (liver and kidney) was examined, has resulted in different interpretations of the data for liver as either positive or negative for genotoxicity. Here, I discuss the statistical approaches used and comment on the different conclusions reached.
Lovell
David
D
Division of Basic Medical Sciences, St George's University of London, Cranmer Terrace, London SW17 0RE, UK. dlovell@sgul.ac.uk
D000818:Animals; D020552:Comet Assay; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051379:Mice; D015233:Models, Statistical; D009153:Mutagens / Q000633:toxicity*; D013750:Tetrachloroethylene / Q000633:toxicity*
D009153:Mutagens; D013750:Tetrachloroethylene