Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects.
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.
Durduran
Turgut
T
ICFO-Institut de Ciencies Fotoniques, Av Canal Olimpic s/n, Castelldefels 08860, Spain. durduran@alumni.upenn.edu
Zhou
Chao
C
Buckley
Erin M
EM
Kim
Meeri N
MN
Yu
Guoqiang
G
Choe
Regine
R
Gaynor
J William
JW
Spray
Thomas L
TL
Durning
Suzanne M
SM
Mason
Stefanie E
SE
Montenegro
Lisa M
LM
Nicolson
Susan C
SC
Zimmerman
Robert A
RA
Putt
Mary E
ME
Wang
Jiongjiong
J
Greenberg
Joel H
JH
Detre
John A
JA
Yodh
Arjun G
AG
Licht
Daniel J
DJ
D002245:Carbon Dioxide / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply*; D006330:Heart Defects, Congenital / Q000097:blood* / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D055095:Optics and Photonics / Q000379:methods*; D010108:Oxyhemoglobins / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013057:Spectrum Analysis / Q000379:methods
D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; C100003:deoxyhemoglobin