[Improved experimental varicocele increases follicle-stimulating hormone and reduces inhibin B in rats].
OBJECTIVE
To evaluate the effects of improved experimental left varicocele (ELV) on follicle-stimulating hormone (FSH) and inhibin B (InhB).


METHODS
ELV models were established by the improved method in 30 SD rats, and another 30 were included in a sham operation group as controls. Three months after the operation, the concentrations of the FSH and InhB were assayed by ELISA.


RESULTS
The concentration of FSH in the serum was significantly higher in the experimental group ([37.56 +/- 9.72] ng/ml) than in the control ([26.69 +/- 5.33] ng/ml) (P < 0.05), while that of InhB significantly lower in the former ([349.93 +/- 99.48] pg/ml) than in the latter ([768. 83 +/- 146.96] pg/ml) (P < 0.05).


CONCLUSIONS
Improved ELV can increase FSH and reduce InhB in rats, which may be associated with subfertility.
Jiang
Ying-Chuan
YC
Department of Urology, The 6th PeopleS Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China. jyc_jiang@163.com
Yu
Jian-Jun
JJ
Yan
Tao
T
Xu
Yue-Min
YM
D000818:Animals; D004195:Disease Models, Animal; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007265:Inhibins / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014646:Varicocele / Q000378:metabolism*
C422364:inhibin B; D007265:Inhibins; D005640:Follicle Stimulating Hormone