A comparative analysis of envelope and tegument proteins of suid herpesvirus 1, bovine herpesvirus 1 and bovine herpesvirus 5.
The aim of this study was to analyze the disordered regions (DRs) in the envelope and tegument proteins of three closely related herpesviruses: bovine herpesvirus 1, bovine herpesvirus 5 and suid herpesvirus 1. Tegument proteins showed a greater percentage of DRs than the envelope proteins did. Regions of disorder were found in the less conserved portions of the proteins, N-terminal and C-terminal regions, and, in a few cases, functionally important sites. The presence of DRs is an important factor in the evolution of viruses, representing points where positive pressure led to structural changes.
Fonseca
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Laboratório de Biologia Molecular, LANAGRO/MG, Avenida Rômulo Joviano, Caixa Postal 50, Pedro Leopoldo, Brazil. augustofj@yahoo.com.br
Heinemann
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MB
Leite
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Reis
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JK
D019143:Evolution, Molecular; D007242:Herpesvirus 1, Bovine / Q000235:genetics*; D011558:Herpesvirus 1, Suid / Q000235:genetics*; D025881:Herpesvirus 5, Bovine / Q000235:genetics*; D011487:Protein Conformation; D017385:Sequence Homology; D015678:Viral Structural Proteins / Q000235:genetics*
D015678:Viral Structural Proteins