Association of the HLA-G gene polymorphism with multiple sclerosis in a Polish population.
Summary In this study, three polymorphic sites in the HLA-G gene: -725C>G>T, -716T>G and 14bp(indel) were genotyped. Significant differences were found between patients and controls in the alleles and genotypes for -725C>G>T and in three-point haplotypes. We observed also a significant difference in the age of disease onset between patients positive and negative for 14bp(ins). The results suggest that single nucleotide polymorphisms in the promoter of the HLA-G gene (mainly -725C>G>T), and 14bp(indel), or some genetic marker in tight linkage disequilibrium with them are associated with multiple sclerosis.
Wiśniewski
A
A
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland. andrzej@iitd.pan.wroc.pl
Bilińska
M
M
Klimczak
A
A
Wagner
M
M
Majorczyk
E
E
Nowak
I
I
Pokryszko-Dragan
A
A
Kuśnierczyk
P
P
D020413:3' Untranslated Regions / Q000235:genetics; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D005805:Genes, MHC Class I; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012720:Severity of Illness Index; D055815:Young Adult
D020413:3' Untranslated Regions; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I