Antipruritic activity of extracts of Humulus scandens, the combinations of bioactive flavonoids.
The antipruritic effects of the ethanol fractions of Humulus scandens on the 4-AP (4-aminopyridine)-induced and chloroquine-induced scratching in ICR mice were examined. The 40% ethanol fractions of H. scandens suppressed both the 4-AP- and chloroquine-induced scratching behavior, which significantly inhibited degranulation of rat peritoneal mast cell and antigen-stimulated histamine release. Further studies proved that the 40% ethanol fractions of H. scandens decreased the content of IL4 in serum of chloroquine-induced scratching ICR mice. The results suggest that the 40% ethanol fractions of H. scandens has antipruritic effects on both antihistamine-resistant and -sensitive pruritus.
Wu
Guanzhong
G
Department of Pharmacology, China Pharmaceutical University, Nanjing, China. zhonghuw@sohu.com
Su
Xin
X
D015761:4-Aminopyridine / Q000633:toxicity; D000818:Animals; D000982:Antipruritics / Q000737:chemistry* / Q000627:therapeutic use*; D002738:Chloroquine / Q000633:toxicity; D003907:Dexamethasone / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006632:Histamine / Q000378:metabolism; D027582:Humulus / Q000737:chemistry*; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010537:Peritoneum / Q000166:cytology; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats
D000982:Antipruritics; D005419:Flavonoids; D003907:Dexamethasone; D006632:Histamine; D002738:Chloroquine; D015761:4-Aminopyridine