The tissue plasminogen activator/plasmin system may act through cleavage of pro-BDNF to increase risk of substance abuse.
Hsu
Cheng-Dien
CD
Tsai
Shih-Jen
SJ
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011498:Protein Precursors / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000209:etiology* / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000235:genetics / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D011498:Protein Precursors; D012333:RNA, Messenger; C426674:brain-derived neurotrophic factor precursor; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin