title: Potential value of color-coded dynamic breast-specific gamma-imaging; comparing (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP in a mouse mammary tumor model.
abstract: Using a mouse mammary tumor model based on orthotopic transplantation of luciferase-expressing mouse ILC cells (KEP1-Luc cells), we evaluated the diagnostic value of three clinically applied tracers: (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP. Uptake of the tracers is compared using static and dynamic imaging procedures. We found that dynamic imaging in combination with pixel-by-pixel color coding has an added value over (high resolution) static imaging procedures. Such dynamic imaging procedures could enhance the potential of breast-specific gamma-imaging.
authors.affiliation: Department of Radiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands. fw.v.leeuwen@nki.nl
authors.forename: Fijs W B
authors.initials: FW
authors.lastname: van Leeuwen
authors.forename: Tessa
authors.initials: T
authors.lastname: Buckle
authors.forename: Lukas
authors.initials: L
authors.lastname: Batteau
authors.forename: Bert
authors.initials: B
authors.lastname: Pool
authors.forename: Michiel
authors.initials: M
authors.lastname: Sinaasappel
authors.forename: Jos
authors.initials: J
authors.lastname: Jonkers
authors.forename: Kenneth G A
authors.initials: KG
authors.lastname: Gilhuijs
mesh_terms: D000818:Animals; D003116:Color; D005260:Female; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging*; D008327:Mammography; D051379:Mice; D018613:Microscopy, Confocal; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals