title: The ARUBA trial: current status, future hopes.
abstract: OBJECTIVE
  Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations.
  
  
  RESULTS
  Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial.
  
  
  CONCLUSIONS
  ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.
authors.affiliation: Columbia University College of Physicians and Surgeons, Neurological Institute, New York, NY 10032-2603, USA. jpm10@columbia.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Mohr
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Moskowitz
authors.forename: Christian
authors.initials: C
authors.lastname: Stapf
authors.forename: Andreas
authors.initials: A
authors.lastname: Hartmann
authors.forename: Karen
authors.initials: K
authors.lastname: Lord
authors.forename: Steven M
authors.initials: SM
authors.lastname: Marshall
authors.forename: Henning
authors.initials: H
authors.lastname: Mast
authors.forename: Ellen
authors.initials: E
authors.lastname: Moquete
authors.forename: Claudia Scala
authors.initials: CS
authors.lastname: Moy
authors.forename: Michael
authors.initials: M
authors.lastname: Parides
authors.forename: John
authors.initials: J
authors.lastname: Pile-Spellman
authors.forename: Rustam
authors.initials: R
authors.lastname: Al-Shahi Salman
authors.forename: Alan
authors.initials: A
authors.lastname: Weinberg
authors.forename: William L
authors.initials: WL
authors.lastname: Young
authors.forename: Alejandrina
authors.initials: A
authors.lastname: Estevez
authors.forename: Inam
authors.initials: I
authors.lastname: Kureshi
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Brisman
mesh_terms: D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000628:therapy*; D016730:Program Development