title: Antibacterial activities of a new brominated diterpene from Borneon Laurencia spp.
abstract: In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.
authors.affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my
authors.forename: Charles Santhanaraju
authors.initials: CS
authors.lastname: Vairappan
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ishii
authors.forename: Tan Kai
authors.initials: TK
authors.lastname: Lee
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhaoqi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001893:Borneo; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D006095:Gram-Positive Cocci / Q000187:drug effects; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044722:Laurencia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010140:Pacific Ocean; D012475:Salmonella / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014734:Vibrio cholerae / Q000187:drug effects
chemical_list: C555913:10-acetoxyangasiol; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D006842:Hydrocarbons, Brominated