Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy.
Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.
Balbi
Massimiliano
M
Department of Medicine, Internal Medicine 3, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy. drbalbim@yahoo.it
Donadon
Valter
V
Ghersetti
Michela
M
Grazioli
Silvia
S
Valentina
Giovanni Della
GD
Gardenal
Rita
R
Mas
Maria Dal
MD
Casarin
Pietro
P
Zanette
Giorgio
G
Miranda
Cesare
C
Cimarosti
Paolo
P
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007558:Italy; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000453:epidemiology; D008113:Liver Neoplasms / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence