New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis.
Two new isoprenylated flavonoids, artotonins A and B (1 and 2), along with 13 known compounds (3-15), were isolated from the roots of Artocarpus tonkinensis A. Chev. ex Gagnep. The structures were elucidated by spectroscopic methods. Cyclocommunol (6), isocyclomulberrin (7), cudraflavone C (11), and morusin (13) exhibited cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines.
Ma
Jian-Ping
JP
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China.
Qiao
Xin
X
Pan
Shu
S
Shen
Hong
H
Zhu
Guo-Fu
GF
Hou
Ai-Jun
AJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C551217:artotonin A; C551216:artotonin B; C057451:morusin