Presumed primary orbital neuroblastoma in a 20-month-old female.
Neuroblastoma is the most common malignant disease of childhood, and it often arises from either the adrenal gland or along the sympathetic chain. The authors report a case of a 20-month-old female with a presumed primary neuroblastoma of the orbit. Radiologically, the tumor showed a brightly enhancing mass lesion of the left side with intraorbital, temporal extraorbital, transsphenoid, and intracranial components. Histopathologically, the tumor was composed of small round blue cells. Immunohistochemical staining was positive for neuron-specific enolase. To the best of the authors' knowledge, primary orbital neuroblastoma has only been previously reported once in children, although it has been reported twice in adults.
Zhang
Nanfei
N
Department of Ophthalmology, University of California, Davis, Sacramento, CA 95817, USA.
Lin
Lily Koo
LK
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009363:Neoplasm Proteins / Q000032:analysis; D009447:Neuroblastoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D009918:Orbital Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins