Gene expression of inflammatory cytokines in peripheral leukocytes in db/db mice rose with progression of diabetes.
Fourteen-week-old db/db mice showed significant higher blood glucose levels than 7 week-old mice. The mRNA levels of IL-1beta and S100a4/a6/a9 in peripheral leukocytes were higher in 14 week-old mice than in 7 week-old mice. Together, inflammatory cytokine/cytokine-like factor mRNA levels in peripheral leukocytes were associated with progression of diabetes in db/db mice.
Fujimoto
Saki
S
Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Global COE Program, University of Shizuoka.
Mochizuki
Kazuki
K
Goda
Toshinao
T
D000818:Animals; D016207:Cytokines / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics* / Q000276:immunology; D018450:Disease Progression; D005786:Gene Expression Regulation; D007249:Inflammation / Q000235:genetics; D007962:Leukocytes / Q000378:metabolism*; D051379:Mice
D016207:Cytokines