Structural analysis of lipopolysaccharides from Gram-negative bacteria.
This review covers data on composition and structure of lipid A, core, and O-polysaccharide of the known lipopolysaccharides from Gram-negative bacteria. The relationship between the structure and biological activity of lipid A is discussed. The data on roles of core and O-polysaccharide in biological activities of lipopolysaccharides are presented. The structural homology of some oligosaccharide sequences of lipopolysaccharides to gangliosides of human cell membranes is considered.
Kabanov
D S
DS
Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. kabanovd1@rambler.ru
Prokhorenko
I R
IR
D016207:Cytokines / Q000378:metabolism; D005227:Fatty Acids / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000737:chemistry*; D006801:Humans; D008050:Lipid A / Q000737:chemistry; D008070:Lipopolysaccharides / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry
D016207:Cytokines; D005227:Fatty Acids; D008050:Lipid A; D008070:Lipopolysaccharides; D009844:Oligosaccharides