title: Continuous intra-arterial infusion of nimodipine at the onset of resistant vasospasm in aneurysmal subarachnoidal haemorrhage. Technical report.
abstract: Cerebral vasospasm complicating the aneurysmal subarachnoid haemorrhage is a well known medical entity. The delayed ischemic neurological deficits (DINDs) as a result of vasospasm, remain the main cause of morbidity among patients who manage to survive this severe disease pattern. When the traditional treatment options either medical or interventional, fail to reverse the vasospasm, continuous intra-arterial infusion of nimodipine through catheters direct in the spastic arteries, presents a promising treatment modality. We treated in our clinic four patients with severe aneurysmal subarachnoid haemorrhage and refractory vasospasms with continuous nimodipine infusion via catheters in both internal carotid arteries and discussed the efficacy of the method presenting an illustrative case and discussing the effect based on doppler examinations.
authors.affiliation: Department of Neurosurgery, University Hospital of Schleswig-Holstein, Campus Kiel, Germany. axlpam@googlemail.com
authors.forename: Alexandros
authors.initials: A
authors.lastname: Doukas
authors.forename: Athanasios Konstantinou
authors.initials: AK
authors.lastname: Petridis
authors.forename: Harald
authors.initials: H
authors.lastname: Barth
authors.forename: Olav
authors.initials: O
authors.lastname: Jansen
authors.forename: Hubertus Maximilian
authors.initials: HM
authors.lastname: Mehdorn
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage*; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000959:Antihypertensive Agents; D009553:Nimodipine