title: Circulating CD34+/133+ progenitor cells in patients with stable angina pectoris undergoing percutaneous coronary intervention.
abstract: BACKGROUND
  This study explored the clinical significance of CD34(+)/133(+) circulating progenitor cell (CPC) counts in patients with stable angina pectoris (AP) who underwent percutaneous coronary intervention (PCI).
  
  
  RESULTS
  Subjects comprised 52 patients with stable AP requiring PCI and 50 control patients without AP. In the AP group, blood samples were taken before and 20 min and 24 h after PCI to measure CPC counts by fluorescence-activated cell sorter analysis. The baseline number of CPCs was smaller in the AP group than in controls. In the AP group, body mass index (BMI) correlated positively with the baseline number of CPCs and was an independent predictor of CPC count in multivariate regression analysis. Other conventional risk factors, daily exercise activity and statin administration showed no association with CPC count. CPC counts remained unchanged within 24 h after PCI.
  
  
  CONCLUSIONS
  CPC counts in patients with AP are influenced by BMI, but not by other coronary risk factors. CPC counts remain unchanged within 24 h after PCI.
authors.affiliation: First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University, Saitama, Japan.
authors.forename: Kenshiro
authors.initials: K
authors.lastname: Arao
authors.forename: Takanori
authors.initials: T
authors.lastname: Yasu
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ohmura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Miho
authors.initials: M
authors.lastname: Murata
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kubo
authors.forename: Tomio
authors.initials: T
authors.lastname: Umemoto
authors.forename: Nahoko
authors.initials: N
authors.lastname: Ikeda
authors.forename: Junya
authors.initials: J
authors.lastname: Ako
authors.forename: San-e
authors.initials: SE
authors.lastname: Ishikawa
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kawakami
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Momomura
mesh_terms: D000071916:AC133 Antigen; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D015703:Antigens, CD; D018952:Antigens, CD34; D001773:Blood Cells / Q000166:cytology; D015992:Body Mass Index; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D005434:Flow Cytometry; D006023:Glycoproteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D019370:Observation; D010455:Peptides; D011446:Prospective Studies; D012307:Risk Factors; D013234:Stem Cells / Q000166:cytology*
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; D006023:Glycoproteins; D010455:Peptides