Auer rod-like inclusions in a low-grade B-cell leukemia.
Auer rods define neoplastic blasts of myeloid origin. However, azurophilic, needle-shaped, Auer rod-like inclusions have rarely been reported in the neoplastic cells of patients with B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma. Here, we report a case of low-grade B-cell leukemia most consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma that displayed numerous intracytoplasmic, needle-shaped, azurophilic rods resembling Auer rods. Furthermore, we review the literature on Auer rod-like structures in B-cell neoplasms.
Hristov
Alexandra C
AC
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Saladino
Andrew
A
Nava
Victor E
VE
Gocke
Christopher D
CD
D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D002469:Cell Separation; D003520:Cyclophosphamide / Q000008:administration & dosage; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D002479:Inclusion Bodies / Q000648:ultrastructure*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D000069283:Rituximab; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D000069283:Rituximab; D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine