Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.
OBJECTIVE
To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.


METHODS
To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.


RESULTS
None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.


CONCLUSIONS
We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.
Tenesa
Albert
A
Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, University of Edinburgh and MRC Human Genetics Unit, Edinburgh, United Kingdom.
Theodoratou
Evropi
E
Din
Farhat V N
FV
Farrington
Susan M
SM
Cetnarskyj
Roseanne
R
Barnetson
Rebecca A
RA
Porteous
Mary E
ME
Campbell
Harry
H
Dunlop
Malcolm G
MG
D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis