title: IL-17 increased in the third trimester in healthy women with term labor.
abstract: BACKGROUND
  The function, peripheral blood expression, and physiologic importance of IL-17 is not well established. Detection of IL-17 in sera and plasma samples from patients with pre-eclampsia has been reported with inconsistent results. To establish the l levels of the IL-17 at peripheral level, we studied prospectively a cohort of 13 healthy pregnant women.
  
  
  OBJECTIVE
  To evaluate the changes in serum levels of IL-17 in healthy pregnant women in a prospective cohort.
  
  
  METHODS
  Thirteen healthy pregnant women were prospectively followed to evaluate serum levels of IL-17. Each patient was evaluated at each trimester. IL-17 levels were measured by ELISA. The statistical analysis was done using repeated measures anova and Bonferroni's multiple comparison test.
  
  
  RESULTS
  IL-17 levels were significantly increased from first trimester with a mean of 14.61 up to 31.78 pg/mL at third trimester (P < 0.05), but when detectable, they were almost identical range in all trimesters.
  
  
  CONCLUSIONS
  We propose that IL-17 levels in healthy women are present with very similar range levels during the whole pregnancy but the average is increased during the third trimester maybe as a part of the complex network of cytokines as a result of implantation, fetal development, and labor process itself.
authors.affiliation: Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México.
authors.forename: Erika A
authors.initials: EA
authors.lastname: Martínez-García
authors.forename: Bernardo
authors.initials: B
authors.lastname: Chávez-Robles
authors.forename: Pedro E
authors.initials: PE
authors.lastname: Sánchez-Hernández
authors.forename: Lourdes
authors.initials: L
authors.lastname: Núñez-Atahualpa
authors.forename: Beatriz T
authors.initials: BT
authors.lastname: Martín-Máquez
authors.forename: Andrea
authors.initials: A
authors.lastname: Muñoz-Gómez
authors.forename: Laura
authors.initials: L
authors.lastname: González-López
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Gámez-Nava
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Páramo
authors.forename: Ingrid
authors.initials: I
authors.lastname: Dávalos-Rodríguez
authors.forename: Marcelo H
authors.initials: MH
authors.lastname: Petri
authors.forename: Diego
authors.initials: D
authors.lastname: Zúñiga-Tamayo
authors.forename: Raúl
authors.initials: R
authors.lastname: Vargas-Ramírez
authors.forename: Mónica
authors.initials: M
authors.lastname: Vázquez-Del Mercado
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood*; D047929:Term Birth; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D020381:Interleukin-17