title: Rare primary effusion lymphoma associated with HHV-8 in Japan.
abstract: We describe a 62-year-old man infected with human immunodeficiency virus (HIV)-1 who developed primary effusion lymphoma (PEL). Pleural effusion contained atypical lymphoid cells with human herpesvirus (HHV)-8 latent nuclear antigen (LANA)(+). Radiological examination revealed pleural and pericardial effusion, but no evidence of tumor mass or lymph node enlargement. The patient was administered with highly active anti retroviral therapy (HAART) and THP-COP therapy, resulting in complete remission. The prevalence of HHV-8 infection among HIV positive individuals is higher than in the general population in Japan. Although PEL is extremely rare in Japan, the incidence might increase in the future.
authors.affiliation: Department of Internal Medicine 2, Oita University Faculty of Medicine, Yufu. tikebe@med.oita-u.ac.jp
authors.forename: Taichi
authors.initials: T
authors.lastname: Ikebe
authors.forename: Yuka
authors.initials: Y
authors.lastname: Amemiya
authors.forename: Masuho
authors.initials: M
authors.lastname: Saburi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Ando
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohno
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Junichi
authors.initials: J
authors.lastname: Kadota
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006566:Herpesviridae Infections / Q000150:complications* / Q000188:drug therapy; D019288:Herpesvirus 8, Human; D006801:Humans; D007564:Japan; D054685:Lymphoma, Primary Effusion / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone