title: A randomized controlled trial comparing an intraoperative goal-directed strategy with routine clinical practice in patients undergoing peripheral arterial surgery.
abstract: OBJECTIVE
  We hypothesized that, in vascular surgery patients, the application of a goal-directed strategy based on a pulse contour-derived cardiac index would be associated with a better haemodynamic status than the application of routine perioperative care and that the amount of fluid and/or inotropes required in such a goal-directed therapy depended on the general anaesthetic technique used.
  
  
  METHODS
  Patients undergoing peripheral arterial bypass grafting were randomly assigned to three groups. In group 1, haemodynamic management was performed according to routine clinical practice. In the two other groups (groups 2 and 3) a goal-directed therapy was applied aiming to maintain the pulse contour-derived cardiac index above 2.5 l m min. Patients in groups 1 and 2 received sevoflurane-based anaesthesia and patients in group 3 propofol-based anaesthesia. Haemodynamic variables, amount of fluid and administration of inotropes were assessed at different time intervals.
  
  
  RESULTS
  The amount of fluid administered was not significantly different between the groups. Two patients in group 1, 13 patients in group 2 and 12 patients in group 3 were treated with dobutamine (P < 0.001). None of the patients anaesthetized with sevoflurane (groups 1 and 2) experienced postoperative cardiovascular complications, whereas four patients in the total intravenous group (group 3) experienced major postoperative cardiovascular complications (P = 0.005).
  
  
  CONCLUSIONS
  In the conditions of the present study, the application of a goal-directed therapy aiming to maintain the cardiac index above 2.5 l min m did not result in a higher tissue oxygen delivery than when applying the standard haemodynamic strategy nor did it depend on the anaesthetic technique used.
authors.affiliation: Department of Anaesthesiology, Centre Hospitalo-Universitaire Brugmann, Free University of Brussels, Brussels, Belgium.
authors.forename: Philippe J
authors.initials: PJ
authors.lastname: Van der Linden
authors.forename: Ann
authors.initials: A
authors.lastname: Dierick
authors.forename: Stéphan
authors.initials: S
authors.lastname: Wilmin
authors.forename: Bernard
authors.initials: B
authors.lastname: Bellens
authors.forename: Stefan G
authors.initials: SG
authors.lastname: De Hert
mesh_terms: D000368:Aged; D000758:Anesthesia / Q000379:methods; D000776:Anesthesiology / Q000379:methods*; D000777:Anesthetics / Q000627:therapeutic use*; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D001808:Blood Vessels / Q000473:pathology*; D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000473:pathology* / Q000601:surgery*; D015742:Propofol / Q000494:pharmacology; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol