title: [Bone metastasis of prostate cancer: an update].
abstract: Prostate cancer shows a strong predilection to spread to the bones. Cancer metastasis is composed of a complex cascade that involves a variety of critical steps beginning with detachment from the primary tumor and ending with growth of the tumor at a distant site. Varus factors produced by the bone microenvironment contribute to the pathogenesis of cancer skeletal metastasis. This review summarizes the multifactorial mechanisms and complex cellular interactions that take place inside the bone metastatic microenvironment.
authors.affiliation: Department of Urology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000473:pathology*