title: Micro- and nanocantilever devices and systems for biomolecule detection.
abstract: Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically improved through the advent of new materials and micro-/nanofabrication technologies. This is especially true for micro-/nanosized cantilever sensors, which undergo a change in mechanical properties upon the specific binding of biomolecules. In this review, we introduce the basic principles of cantilever biosensors in static and dynamic modes. We also summarize a range of approaches to cantilever design, fabrication, and instrumentation according to their applications. More specifically, we describe cantilever-based detections of proteins, DNA molecules, bacteria, and viruses and discuss current challenges related to the targets' biophysical characteristics.
authors.affiliation: Nano-Bio Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea.
authors.forename: Kyo Seon
authors.initials: KS
authors.lastname: Hwang
authors.forename: Sang-Myung
authors.initials: SM
authors.lastname: Lee
authors.forename: Sang Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Tae Song
authors.initials: TS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004247:DNA / Q000032:analysis; D006801:Humans; D008904:Miniaturization / Q000295:instrumentation / Q000379:methods; D011506:Proteins / Q000032:analysis; D014780:Viruses / Q000302:isolation & purification
chemical_list: D011506:Proteins; D004247:DNA