title: Respiratory mechanics and fluid dynamics after lung resection surgery.
abstract: Thoracic surgery that requires resection of a portion of lung or of a whole lung profoundly alters the mechanical and fluid dynamic setting of the lung-chest wall coupling, as well as the water balance in the pleural space and in the remaining lung. The most frequent postoperative complications are of a respiratory nature, and their incidence increases the more the preoperative respiratory condition seems compromised. There is an obvious need to identify risk factors concerning mainly the respiratory function, without neglecting the importance of other comorbidities, such as coronary disease. At present, however, a satisfactory predictor of postoperative cardiopulmonary complications is lacking; postoperative morbidity and mortality have remained unchanged in the last 10 years. The aim of this review is to provide a pathophysiologic interpretation of the main respiratory complications of a respiratory nature by relying on new concepts relating to lung fluid dynamics and mechanics. New parameters are proposed to improve evaluation of respiratory function from pre- to the early postoperative period when most of the complications occur.
authors.affiliation: Department of Experimental Medicine, Università di Milano-Bicocca, Via Cadore 48, Monza 20052, Italy. giuseppe.miserocchi@unimib.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Miserocchi
authors.forename: Egidio
authors.initials: E
authors.lastname: Beretta
authors.forename: Ilaria
authors.initials: I
authors.lastname: Rivolta
mesh_terms: D005541:Forced Expiratory Volume; D006801:Humans; D006876:Hydrothorax / Q000503:physiopathology; D008170:Lung Compliance / Q000502:physiology; D010101:Oxygen Consumption; D011013:Pneumonectomy; D011184:Postoperative Period; D011656:Pulmonary Emphysema / Q000503:physiopathology; D011658:Pulmonary Fibrosis / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000502:physiology*; D013908:Thoracotomy; D014939:Work of Breathing / Q000502:physiology