title: A facile method for the synthesis of oxindole based quaternary alpha-aminonitriles via the Strecker reaction.
abstract: The direct alpha-cyanoamination of isatins using TMSCN has been developed, which is carried out in methanol without any catalyst. A new bifunctional cinchona alkaloid-based phosphinamide catalyst 7 could promote the Strecker reaction of isatins derived ketimine with TMSCN in up to 74% ee.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China.
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Cao
authors.forename: Cong-Bin
authors.initials: CB
authors.lastname: Ji
authors.forename: Miao
authors.initials: M
authors.lastname: Ding
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000588:Amines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007211:Indoles; D009570:Nitriles; D000078183:Oxindoles; C022960:2-oxindole