title: Synthesis and biological evaluation of indolyl chalcones as antitumor agents.
abstract: A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively.
authors.affiliation: Birla Institute of Technology and Science, Pilani, India. dalipk@bits-pilani.ac.in
authors.forename: Dalip
authors.initials: D
authors.lastname: Kumar
authors.forename: N Maruthi
authors.initials: NM
authors.lastname: Kumar
authors.forename: Kanako
authors.initials: K
authors.lastname: Akamatsu
authors.forename: Eriko
authors.initials: E
authors.lastname: Kusaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Harada
authors.forename: Takeo
authors.initials: T
authors.lastname: Ito
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones