[Application of hemoperfusion in children with acute tetramine poisoning].
OBJECTIVE
To investigate the efficacy of hemoperfusion treatment in children with acute tetramine poisoning.


METHODS
Thirty-two children aged from 1 to 8 years ( mean 4.6+/-2.4 years) with acute tetramine poisoning received hemoperfusion treatment. Serum tetramine concentrations were measured by gas chromatography before hemoperfusion, 1 and 2 hrs after hemoperfusion initiation and 12 and 24 hrs by the end of hemoperfusion. The median time for full recovery of consciousness and the time to seizure control were observed.


RESULTS
Seventeen children received hemoperfusion treatment for one time, 12 for twice, 2 for 4 times and 1 for 3 times. Twenty- seven (84%) cases recovered, 2 (7%) cases improved and 3 (9%) cases died of multi-organ failure. The serum tetramine concentrations 1 and 2 hrs after hrmoperfusion initiation were significantly lower than those before hemoperfusion (P<0.01). The serum tetramine concentrations 12 and 24 hrs by the end of hemoperfusion were also significantly lower than those before hemoperfusion (P<0.01). The median time for full recovery of consciousness and the time to seizure control were 5.4+/-4.2 and 10.1+/-7.3 hrs, respectively.


CONCLUSIONS
Hemoperfusion treatment is effective for acute tetramine poisoning in children.
Song
Jia-Rong
JR
Hemo-purification Centre, Xiangya Hospital, Central South University, Changsha 410008, China. songjiar2004@sina.com
Huang
Ming-Xia
MX
Mao
Hua-Xiong
HX
Zhou
Hui-Min
HM
D000208:Acute Disease; D001952:Bridged-Ring Compounds / Q000097:blood / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007223:Infant; D008297:Male; D013997:Time Factors
D001952:Bridged-Ring Compounds; C010349:tetramethylenedisulfotetramine