title: Role of rhenium-188 tin colloid radiosynovectomy in patients with inflammatory knee joint conditions refractory to conventional therapy.
abstract: OBJECTIVE
  To evaluate the treatment response of rhenium-188 (¹⁸⁸Re) tin colloid radiosynovectomy (¹⁸⁸Re-RSV) in patients with inflammatory knee joint conditions refractory to conventional treatment.
  
  
  METHODS
  Sixty-one knee joints in 48 patients with chronic synovitis caused by various inflammatory knee joint diseases refractory to conventional therapy were included in this prospective study. All patients were assessed clinically for pain, tenderness, joint swelling, mobility, analgesic intake, and blood pool activity on bone scan. Different scores were assigned to all these parameters. RSV of knee joint was done using intra-articular injection of 555 MBq of ¹⁸⁸Re tin colloid. Response was assessed at 3, 6, and 12 months using various clinical parameter scores and blood pool bone scan mentioned above and categorized as responders and nonresponders on the basis of change in percentage of cumulative scores.
  
  
  RESULTS
  Of the 61 joints, 57 were responder and four were nonresponder at 3-month post-RSV. Out of 57 responders, seven had recurrence on further follow-up (three at 6 months and four at 12 months). There was a statistically significant reduction in clinical parameters cumulative scores at 3, 6, and 12 months when compared with baseline (P<0.0001) in responder group. Blood pool scinitgraphy also showed decrease in blood pool activity compared with the baseline. There was statistically significant association between the responder group and shorter duration of disease (P=0.011). Patients having normal or minor X-ray changes, little or no swelling, mild tenderness, and better mobility were independently associated with good response.
  
  
  CONCLUSIONS
  ¹⁸⁸Re tin colloid synovectomy is a useful treatment modality in patients with chronic inflammatory knee joint conditions refractory to conventional treatment. Patients with shorter duration of disease, normal or minor X-ray findings, little or no swelling, mild tenderness, and better mobility are better candidates for RSV.
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Shamim Ahmed
authors.initials: SA
authors.lastname: Shamim
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Dhanapathi
authors.initials: D
authors.lastname: Halanaik
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Varun
authors.initials: V
authors.lastname: Shandal
authors.forename: Jaya
authors.initials: J
authors.lastname: Shukla
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Vivek
authors.initials: V
authors.lastname: Trikha
authors.forename: Prem
authors.initials: P
authors.lastname: Chandra
authors.forename: Gurupad
authors.initials: G
authors.lastname: Bandopadhayaya
authors.forename: Arun
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics; D018771:Arthralgia / Q000175:diagnosis; D001168:Arthritis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D003102:Colloids; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009068:Movement; D011868:Radioisotopes / Q000627:therapeutic use*; D016634:Radiosurgery / Q000379:methods*; D012211:Rhenium / Q000737:chemistry / Q000627:therapeutic use*; D000074402:Synovectomy; D014001:Tin / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000700:Analgesics; D003102:Colloids; D011868:Radioisotopes; D012211:Rhenium; D014001:Tin