Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure.
Previous studies suggested that gamma oscillations in the brain are associated with higher order cognitive function including selective visual attention, motor task planning, sensory perception, working memory and dreaming REM sleep. These oscillations are mainly observed in cortical regions and also occur in neocortical and subcortical areas and the hippocampus. In this paper, we investigate the influence of acute exposure to nicotine on the complexity of hippocampal gamma oscillations.Using the approximate entropy method, the influence of acute nicotine exposure on the hippocampal gamma oscillations was investigated. The hippocampal gamma oscillations have been generated in response to the 100 Hz stimulus and isolated using the visual inspection and spectral analysis method. Our central hypothesis is that acute exposure to nicotine significantly reduces the complexity of hippocampal gamma oscillations. We used brain-slice recordings and the approximate entropy method to test this hypothesis. The approximate entropy (complexity) values of the hippocampal gamma oscillations are estimated from the 14 hippocampal slices. Our results show that it takes at least 100 msec to see any hippocampal activities in response to the 100 Hz stimulus. These patterns noticeably changed after 100 msec until 300 msec after the stimulus Finally, they were less prominent after 300 msec. We have analyzed the isolated hippocampal gamma oscillations (between 150 and 250 msec after the stimulus) using the approximate entropy (ApEn) method. Our results showed that the ApEn (complexity) values of hippocampal gamma oscillations during nicotine exposure were reduced compared to those of hippocampal gamma oscillations during control, and washout. This reduction was much more significant in response to acute nicotine exposure (p < 0.05) compared to those during control and washout conditions. These results suggest that the neural firing becomes regular and the hippocampal networks become synchronized in response to nicotine exposure.
Akkurt
David
D
Harrington Department of Bioengineering, Fulton School of Engineering ASU, Tempe AZ, USA.
Akay
Yasemin M
YM
Akay
Metin
M
D000465:Algorithms; D000818:Animals; D003344:Cortical Synchronization / Q000187:drug effects*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008839:Microelectrodes; D009434:Neural Pathways / Q000502:physiology; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010507:Periodicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D018722:Nicotinic Agonists; D009538:Nicotine