title: Our wormy world genomics, proteomics and transcriptomics in East and southeast Asia.
abstract: Helminths are the cause of some of the major infectious diseases of humanity in what is still a "wormy" world. There is, in East and Southeast Asia, a high prevalence of several helminthiases which occur primarily in rural, impoverished areas of low-income and developing countries throughout the tropics and subtropics. Subsequent to various parasite genome projects that commenced in the early 1990s, under the aegis of the World Health Organization (WHO), the draft genomes of three major helminth species (Schistosoma japonicum, S. mansoni and Brugia malayi) have been sequenced, and many other helminth parasites have now been targeted for intensive genomics investigation. The continuing release of genome sequences has catalyzed the emergence of transcriptomics, proteomics and related "-omics" analyses of helminth parasites, which provide unprecedented approaches to understanding their biology that will result in new clues for the development of novel control interventions. In this review, we present a summary of current approaches employed in helminth "-omics" studies and review recent advances in helminth genomics and post-genomics in the Southeast Asian setting.
authors.affiliation: Key Laboratory of Parasitology and Vector Biology, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chuan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Feng
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Brindley
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
authors.forename: Zeguang
authors.initials: Z
authors.lastname: Han
authors.forename: Peng
authors.initials: P
authors.lastname: Jianxin
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
mesh_terms: D000818:Animals; D001210:Asia, Southeastern / Q000453:epidemiology; D035843:Biomedical Research / Q000639:trends*; D005202:Asia, Eastern / Q000453:epidemiology; D020869:Gene Expression Profiling; D016678:Genome; D006373:Helminthiasis / Q000453:epidemiology* / Q000469:parasitology; D006376:Helminths / Q000737:chemistry / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D020543:Proteome
chemical_list: D020543:Proteome