title: Ampullosine, a new isoquinoline alkaloid from Sepedonium ampullosporum (Ascomycetes).
abstract: A new isoquinoline alkaloid, ampullosine (3-methyl-isoquinoline-6-carboxylic acid, 1), was isolated from Sepedonium ampullosporum and characterized by spectroscopic analysis and chemical reactions. This compound is responsible for the deep yellow color of the culture fluid of this species. Moreover, the known compounds sepedonin (2) and anhydrosepedonin (3) were detected. Twelve strains belonging to eight species of Sepedonium have been screened for these three metabolites by LC/ESI-SRM (selected reaction monitoring). Ampullosine (1) could be detected in almost all species in Sepedonium, but not in the phylogenetically more distant species S. brunneum and S. tulasneanum. Anhydrosepedonin (3) showed antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum.
authors.affiliation: Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schmidt
authors.forename: Andrea
authors.initials: A
authors.lastname: Porzel
authors.forename: Ludger
authors.initials: L
authors.lastname: Wessjohann
authors.forename: Mark
authors.initials: M
authors.lastname: Haid
authors.forename: Norbert
authors.initials: N
authors.lastname: Arnold
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D007546:Isoquinolines; C551425:ampullosine