Consensus paper: use of transcranial magnetic stimulation to probe motor cortex plasticity in dystonia and levodopa-induced dyskinesia.
Plasticity includes the ability of the nervous system to optimize neuronal activity at a cellular and system level according to the needs imposed by the environment. Neuroplasticity phenomena within sensorimotor cortex are crucial to enhance function to increase skillfulness. Such plasticity may be termed "adaptive" to indicate its ecologically beneficial role. In professional musicians, enhanced adaptive plasticity is associated with one of the highest level of motor skill a human being can achieve and the amount of these changes is even dependent on the age at which instrumental playing was started. In addition, adaptive neuroplastic changes occur when nervous system try to repair itself thus compensating dysfunctions. However, when these adaptive phenomena are pushed to an extreme, they can produce a maladaptive sensorimotor reorganization that interferes with motor performance rather than improving it. The model we discuss here is focal hand dystonia I which an intrinsic abnormality of neural plasticity, in some predisposed individuals, may lead to abnormal sensorimotor integration and to the appearance of a characteristic movement disorder. Deficient homeostatic control might be an important mechanism triggering this maladaptive reorganization, and future behavioral studies are needed to confirm this hypothesis. In the second part of this consensus paper, we will critically discuss as a second model, the hypothesis that levodopa-induced dyskinesia correlate with an aberrant form of plasticity in the human primary motor cortex, possibly because of abnormal oscillations within the basal ganglia loop. Disorders of cortical plasticity have not in the past been considered as possible causes of human clinical states. The recognition that this can occur, together with a speculative mechanism, generates an important and provocative hypothesis for future research at the clinical-scientific interface.
Quartarone
Angelo
A
Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Italy. angelo.quartarone@unime.it
Classen
Joseph
J
Morgante
Francesca
F
Rosenkranz
Karin
K
Hallett
Mark
M
D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology; D020820:Dyskinesias / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D020821:Dystonic Disorders / Q000503:physiopathology / Q000628:therapy; D006225:Hand / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
D007980:Levodopa