A role for SIRT1 in the hypoxic response.
In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.
Leiser
Scott F
SF
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
Kaeberlein
Matt
M