title: Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.
abstract: We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA.
authors.forename: Neda
authors.initials: N
authors.lastname: Ahmadi
authors.forename: Radoslav
authors.initials: R
authors.lastname: Goldman
authors.forename: Françoise
authors.initials: F
authors.lastname: Seillier-Moiseiwitsch
authors.forename: Anne-Michelle
authors.initials: AM
authors.lastname: Noone
authors.forename: Ourania
authors.initials: O
authors.lastname: Kosti
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Davidson