Complexation of tocotrienol with gamma-cyclodextrin enhances intestinal absorption of tocotrienol in rats.
To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.
Ikeda
Saiko
S
Department of Nutritional Sciences, Nagoya University of Arts and Sciences. saiko@nuas.ac.jp
Uchida
Tomono
T
Ichikawa
Tomio
T
Watanabe
Takashi
T
Uekaji
Yukiko
Y
Nakata
Daisuke
D
Terao
Keiji
K
Yano
Tomohiro
T
D000818:Animals; D001682:Biological Availability; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D024508:Tocotrienols / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D024508:Tocotrienols; D014280:Triglycerides; D047408:gamma-Cyclodextrins