Effect of continuous ingestion of acetic Acid bacteria on memory retention and the synaptic function in aged rats.
We administered Acetobacter malorum NCI1683 (S24), containing a high concentration of dihydroceramide (7.2 mg/g of dry cell weight), consecutively to aged rats (male Crlj:Wistar rats, 22 months old). The ingestion of Acetobacter malorum for 89 d significantly extended the memory retention in passive avoidance tests, increased the release of acetylcholine with depolarization of brain synaptosomes and decreased the causative agents of neurodegenerative diseases in the cerebral cortices.
Fukami
Hiroyuki
H
Central Research Institute, Mizkan Group Corporation, Handa, Aichi. h-fukami@mizkan.co.jp
Kobayashi
Satoru
S
Tachimoto
Hideki
H
Kishi
Mikiya
M
Kaga
Takayuki
T
Waki
Hatsue
H
Iwamoto
Machiko
M
Tanaka
Yasukazu
Y
D019342:Acetic Acid / Q000378:metabolism*; D000091:Acetobacter / Q000378:metabolism*; D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004435:Eating; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000382:microbiology* / Q000502:physiology*; D013997:Time Factors
D015415:Biomarkers; D019342:Acetic Acid