The demographic and biomedical case for late-life interventions in aging.
The social and medical costs of the biological aging process are high and will rise rapidly in coming decades, creating an enormous challenge to societies worldwide. In recent decades, researchers have expanded their understanding of the underlying deleterious structural and physiological changes (aging damage) that underlie the progressive functional impairments, declining health, and rising mortality of aging humans and other organisms and have been able to intervene in the process in model organisms, even late in life. To preempt a global aging crisis, we advocate an ambitious global initiative to translate these findings into interventions for aging humans, using three complementary approaches to retard, arrest, and even reverse aging damage, extending and even restoring the period of youthful health and functionality of older people.
Rae
Michael J
MJ
Strategies for Engineered Negligible Senescence (SENS) Foundation, Sunnyvale, CA 94089, USA.
Butler
Robert N
RN
Campisi
Judith
J
de Grey
Aubrey D N J
AD
Finch
Caleb E
CE
Gough
Michael
M
Martin
George M
GM
Vijg
Jan
J
Perrott
Kevin M
KM
Logan
Barbara J
BJ
D000368:Aged; D000375:Aging / Q000473:pathology*; D003710:Demography; D006291:Health Policy; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D011634:Public Health / Q000706:statistics & numerical data; D044968:Regenerative Medicine / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends*