title: Lipidomics: coming to grips with lipid diversity.
abstract: Although lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood. The exact mechanisms of how compositional complexity affects cell homeostasis and its regulation also remain unclear. This emerging field is developing sensitive mass spectrometry technologies for the quantitative characterization of the lipidome. Here, we argue that lipidomics will become an essential tool kit in cell and developmental biology, molecular medicine and nutrition.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
authors.forename: Andrej
authors.initials: A
authors.lastname: Shevchenko
authors.forename: Kai
authors.initials: K
authors.lastname: Simons
mesh_terms: D004194:Disease / Q000209:etiology; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis / Q000737:chemistry*; D013058:Mass Spectrometry; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D055432:Metabolomics; D015394:Molecular Structure
chemical_list: D008055:Lipids; D008563:Membrane Lipids; D008565:Membrane Proteins