Assessment of endothelial function by means of flow-mediated changes using pulse wave velocity.
Endothelial dysfunction is a leading cause of early development of cardiovascular diseases. Endothelial function can be assessed using ultrasound methods to watch the arterial flow-mediated dilation. It is also possible to find changes in pulse wave velocity (PWV) after induced ischemia related to the vessel diameter changes. Pre- and post-induced ischemia carotid-radial PWV was recorded in 226 hypertensive patients (150 women [63.5+/-12.4 years old] and 76 men [63.2+/-11.8 years old] and 55 healthy patients (38 women [63.1+/-12.6 years old] and 17 men [54.8+/-12.8 years old]). The authors considered normal endothelial function a PWV reduction of 5% from baseline. To assess nondependent endothelial dilation the authors performed carotid-radial PWV after sublingual administration of 5 mg of isosorbide dinitrate in a group of patients with abnormal flow-mediated dilation. A significant PWV reduction of 9.8% in normal patients and only 1.2% among hypertensive patients (P<.0005) was found. After sublingual isosorbide dinitrate intake the authors observed a greater fall in PWV (14%) than that observed in healthy people after induced ischemia. Carotid-radial PWV after induced ischemia decreased significantly in normal participants. No significant changes were observed in hypertensive patients. These results may offer a reliable tool to assess endothelial function in medium-size arteries.
Rusak
Eduardo J
EJ
Laboratory of Hypertension, División Cardiología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina. erusak@arnet.com.ar
Bellido
Claudio A
CA
Iavicoli
Oscar R
OR
Vazquez
Sonia T
ST
Duarte
Mariano
M
Lerman
Jorge
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2; D003971:Diastole / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007249:Inflammation; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D015999:Multivariate Analysis; D009569:Nitric Oxide; D018384:Oxidative Stress; D013599:Systole / Q000187:drug effects
D000959:Antihypertensive Agents; D009569:Nitric Oxide