title: 5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder.
abstract: We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype.
authors.affiliation: Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. tarou@med.niigata-u.ac.jp
authors.forename: Taro
authors.initials: T
authors.lastname: Endo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kitamura
authors.forename: Ryu
authors.initials: R
authors.lastname: Tamura
authors.forename: Jun
authors.initials: J
authors.lastname: Egawa
authors.forename: Takuro
authors.initials: T
authors.lastname: Sugai
authors.forename: Naoki
authors.initials: N
authors.lastname: Fukui
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics* / Q000473:pathology*; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009448:Neurochemistry; D011110:Polymorphism, Genetic / Q000235:genetics*; D017397:Prefrontal Cortex / Q000378:metabolism*; D011522:Protons; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D011522:Protons; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine