title: [Autogenous platelet-rich plasma gel with acellular xenogeneic dermal matrix for treatment of deep II degree burns].
abstract: OBJECTIVE
  To investigate the effectiveness of autogenous platelet-rich plasma (PRP) gel with acellular xenogeneic dermal matrix in the treatment of deep II degree burns.
  
  
  METHODS
  From January 2007 to December 2009, 30 cases of deep II degree burns were treated. There were 19 males and 11 females with an average age of 42.5 years (range, 32-57 years). The burn area was 10% to 48% of total body surface area. The time from burn to hospitalization was 30 minutes to 8 hours. All patients were treated with tangential excision surgery, one side of the wounds were covered with autogenous PRP gel and acellular xenogeneic dermal matrix (PRP group), the other side of the wounds were covered with acellular xenogeneic dermal matrix only (control group). The healing rate, healing time, infection condition, and scar formation were observed.
  
  
  RESULTS
  At 7 days after operation, the infection rate in PRP group (6.7%, 2/30) was significantly lower than that in control group (16.7%, 5/30, P < 0.05). The healing times were (18 +/- 4) days and (22 +/- 4) days respectively in PRP group and control group, showing significant difference (P < 0.05). The healing rates at 14 days and 21 days were 75% +/- 7% and 88% +/- 5% in PRP group, were 62% +/- 15% and 73% +/- 7% in control group, showing significant difference (P < 0.05). RPR group was superior to control group in elasticity, color, appearance, softness, scar formation, and healing quality.
  
  
  CONCLUSIONS
  Autogenous PRP gel with acellular xenogeneic dermal matrix can accelerate the wound healing of deep II degree burns as well as alleviate the scar proliferation.
authors.affiliation: Department of Burn and Plastic Surgery, General Hospital of Beijing Command, Beijing, 100125, P.R.China. htz.jn@126.com
authors.forename: Tianzhi
authors.initials: T
authors.lastname: Hao
authors.forename: Jingmin
authors.initials: J
authors.lastname: Zhu
authors.forename: Wenbo
authors.initials: W
authors.lastname: Hu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhenhui
authors.initials: Z
authors.lastname: Gao
authors.forename: Xuehui
authors.initials: X
authors.lastname: Wen
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.forename: Jingjie
authors.initials: J
authors.lastname: Liu
authors.forename: Wen
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D002056:Burns / Q000628:therapy*; D020405:Dermis / Q000637:transplantation*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014945:Wound Healing
chemical_list: D005782:Gels