title: Necrotizing sialometaplasia in a patient who is HIV positive: a case report.
abstract: Necrotizing sialometaplasia (NS) is a self-limiting, benign, inflammatory disease of the minor salivary glands of the hard palate. The main significance of the NS lesion lies in the fact that it may be mistaken for mucoepidermoid or squamous cell carcinoma. A case report is presented of a patient with NS who was HIV positive; the lesion was located in the minor salivary glands of the hard palate. Clinically, the lesion presented as a deep ulcer with slightly elevated irregular borders and a necrotic base in the hard palate. Histologically, the tissue was characterized by squamous metaplasia of ducts and acini, lobular coagulation necrosis, and pseudoepitheliomatous hyperplasia of the overlying epithelium. The lesion disappeared completely after 2 weeks.
authors.affiliation: Institute and Research Center São Leopoldo Mandic, Campinas, São Paulo, Brazil. alessandradutrasilva@hotmail.com
authors.forename: Alessandra Dutra
authors.initials: AD
authors.lastname: Silva
authors.forename: Carolina Amália Barcellos
authors.initials: CA
authors.lastname: Silva
authors.forename: Cristiane
authors.initials: C
authors.lastname: Furuse
authors.forename: Rodrigo Calado
authors.initials: RC
authors.lastname: Nunes e Souza
authors.forename: Mauro Henrique Melo
authors.initials: MH
authors.lastname: da Costa
authors.forename: Vera Cavalcanti
authors.initials: VC
authors.lastname: de Araújo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003937:Diagnosis, Differential; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis; D019226:Oral Ulcer / Q000175:diagnosis; D021362:Palate, Hard / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*; D012797:Sialometaplasia, Necrotizing / Q000175:diagnosis*