title: Regional trends in prostate cancer incidence, treatment with curative intent and mortality in Norway 1980-2007.
abstract: OBJECTIVE
  To compare the trends in prostate cancer incidence, treatment with curative intent and mortality across regions and counties in Norway, and to consider changes in incidence (an indicator for early diagnosis) and treatment with curative intent as explanatory factors for the decreasing prostate cancer mortality rates.
  
  
  METHODS
  Prostate cancer incidence and mortality data (1980-2007) alongside treatment data (1987-2005) were obtained from the national, population-based Cancer Registry of Norway. Joinpoint regression models were fitted to age-adjusted incidence, treatment and mortality rates to identify linear changes in the trends.
  
  
  RESULTS
  Both age-adjusted incidence rates and rates of curative treatment of prostate cancer increased significantly in all five regions of Norway since the early 1990s. There was a strong positive correlation between increasing incidence and increasing use of curative treatment. The frequency of curative treatment in Western Norway was almost threefold that in the Northern and Central regions around year 2000. Subsequently, the regional trends converged and only minor differences in prostate cancer incidence and use of curative treatment were observed by 2005. The declines in mortality were observed earliest in the regions with the highest incidence and the most frequent use of curative treatment, while the largest decreases in mortality were found in counties where the largest increases in curative treatment were observed.
  
  
  CONCLUSIONS
  The elucidation of the prostate cancer mortality trends is hindered by an inability to tease out the potential effects of early treatment from the more general impact of improved and more active treatment. However, it is likely that both sets of intervention have contributed to the decline in prostate cancer mortality in Norway since 1996.
authors.affiliation: Department of Clinical and Registry-based research, The Cancer Registry of Norway, Oslo, Norway. rune.kvale@kreftregisteret.no
authors.forename: R
authors.initials: R
authors.lastname: Kvåle
authors.forename: B
authors.initials: B
authors.lastname: Møller
authors.forename: A
authors.initials: A
authors.lastname: Angelsen
authors.forename: O
authors.initials: O
authors.lastname: Dahl
authors.forename: S D
authors.initials: SD
authors.lastname: Fosså
authors.forename: O J
authors.initials: OJ
authors.lastname: Halvorsen
authors.forename: L
authors.initials: L
authors.lastname: Hoem
authors.forename: A
authors.initials: A
authors.lastname: Solberg
authors.forename: R
authors.initials: R
authors.lastname: Wahlqvist
authors.forename: F
authors.initials: F
authors.lastname: Bray
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D009664:Norway / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000401:mortality* / Q000628:therapy; D012042:Registries; D015996:Survival Rate; D016896:Treatment Outcome