Seizures triggered by food intake in antimuscarinic-treated fasted animals: evaluation of the experimental findings in terms of similarities to eating-triggered epilepsy.
Food intake triggers convulsions in fasted mice and rats treated with antimuscarinic drugs, scopolamine or atropine. Bearing some similarities in triggering factor and manifestations of the seizures in patients with eating-evoked epilepsy, seizures in fasted animals may provide insight into the mechanism(s) of this rare and partially controlled form of reflex epilepsy.
Enginar
Nurhan
N
Department of Pharmacology and Clinical Pharmacology, Istanbul Faculty of Medicine, Istanbul, Turkey. engnur@istanbul.edu.tr
Nurten
Asiye
A
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001285:Atropine / Q000494:pharmacology; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D020195:Epilepsy, Reflex / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D005215:Fasting / Q000502:physiology; D007003:Hypoglycemia / Q000503:physiopathology; D051379:Mice; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology
D000927:Anticonvulsants; D018727:Muscarinic Antagonists; D017470:Receptors, Glutamate; D001285:Atropine; D012601:Scopolamine