Human herpesvirus-6 entry into host cells.
Human herpesvirus-6 (HHV-6) belongs to the herpesvirus family and is categorized into variant A and B (HHV-6A and HHV-6B). Primary HHV-6 infection in children and its related diseases are almost exclusively caused by HHV-6B and no disease caused by HHV-6A has been identified. The cellular receptor of HHV-6 has been shown to be a human CD46, and its viral ligand is an envelope glycoprotein complex, gH/gL/gQ1/gQ2 in HHV-6A. Furthermore, both cellular and viral lipid rafts play an important role in the HHV-6 entry process, suggesting that HHV-6 may enter its target cells through a lipid raft-associated mechanism.
Tang
Huamin
H
Laboratoy of Virology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8, Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.
Mori
Yasuko
Y
D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D051916:Membrane Cofactor Protein / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D008954:Models, Biological; D011991:Receptors, Virus / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000378:metabolism; D053586:Virus Internalization
C497857:CD46 protein, human; D051916:Membrane Cofactor Protein; D011991:Receptors, Virus; D014759:Viral Envelope Proteins