title: Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study.
abstract: BACKGROUND
  In the present investigation we compared blood epinephrine (EPI), norepinephrine (NE), free fatty acids (FFA) and glycerol concentrations in response to a capsaicinoid supplement or placebo in healthy adults before and after acute exercise.
  
  
  METHODS
  Twenty subjects ingested a placebo or supplement (Capsimax, OmniActive Health Technologies; 2 mg capsaicinoids in a microencapsulated matrix) with one week separating conditions. Fasting blood samples were collected during each visit; 30 minutes following a rest period and before placebo or supplement intake (Pre); 2 hours post intake (2 hr); one minute following the cessation of 30 minutes of exercise performed at 65% of maximal heart rate reserve (2.5 hr); 90 minutes following the cessation of exercise (4 hr). Heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure were recorded at all times.
  
  
  RESULTS
  A time effect was noted for HR, SBP, and DBP (p < 0.05), with HR and SBP higher at 2.5 hr compared to Pre (due to exercise) and DBP lower at 2.5 hr compared to Pre. No interaction or condition effects were noted for EPI, NE, FFA, or glycerol (p > 0.05). However, a time effect was noted for all variables (p < 0.0001), with values higher than Pre at 2.5 hr for EPI and glycerol, at 2 hr and 2.5 hours for FFA, and at 2 hr, 2.5 hr, and 4 hr for NE (p < 0.05). In terms of percent change from Pre, glycerol was higher with Capsimax than for placebo at 4 hr (p = 0.011) and FFA was higher with Capsimax than for placebo at 2 hr (p = 0.025) and at 2.5 hr (p = 0.015).
  
  
  CONCLUSIONS
  Ingestion of low dose (2 mg) Capsimax was associated with an increase in blood FFA and glycerol at selected times post ingestion, as compared to placebo. However, Capsimax had no differing effect on EPI or NE compared to placebo. Lastly, no difference was noted in HR, SBP, or DBP between placebo and Capsimax.
authors.affiliation: Cardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, University of Memphis, Memphis, TN, USA. rbloomer@memphis.edu
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Bloomer
authors.forename: Robert E
authors.initials: RE
authors.lastname: Canale
authors.forename: Sid
authors.initials: S
authors.lastname: Shastri
authors.forename: Sujata
authors.initials: S
authors.lastname: Suvarnapathki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002211:Capsaicin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018592:Cross-Over Studies; D019587:Dietary Supplements / Q000009:adverse effects; D004311:Double-Blind Method; D004837:Epinephrine / Q000097:blood* / Q000378:metabolism; D015444:Exercise; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D008863:Microspheres; D009638:Norepinephrine / Q000097:blood* / Q000378:metabolism; D050177:Overweight / Q000178:diet therapy; D050916:TRPV Cation Channels / Q000819:agonists; D013997:Time Factors; D055815:Young Adult
chemical_list: D019440:Anti-Obesity Agents; D015415:Biomarkers; D005230:Fatty Acids, Nonesterified; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D005990:Glycerol; C517386:nordihydrocapsaicin; D002211:Capsaicin; C012906:dihydrocapsaicin; D009638:Norepinephrine; D004837:Epinephrine