New fluorous/organic biphasic systems achieved by solvent tuning.
Miscibility tests between sixty pairs of fluorous and organic solvents have been performed, and a number of biphasic systems based on hydrofluoroether solvents have been identified. Mutual solubilities of a series of fluorous and organic solvents have been measured to ascertain the compositions of the biphasic systems. A qualitative solvent tuning strategy based on solvent polarity and fluorophilicity/phobicity is introduced. Solvent tuning is then used to modulate the partition coefficients (P) of triarylphosphines with 0-3 fluorous tags. The results lay a foundation for future applications of these and related biphasic systems in catalysis and extraction.
Chu
Qianli
Q
Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, Pennsylvania 15238.
Yu
Marvin S
MS
Curran
Dennis P
DP