title: [Usefulness of magnetic resonance imaging in Churg-Strauss syndrome related cardiac involvement. A case series of three patients and literature review].
abstract: OBJECTIVE
  The reported prevalence of cardiac complications is variable in patients with Churg-Strauss syndrome (15-92%) and depends on diagnostic tools. Diagnosis at early stage of heart involvement is crucial, resulting in appropriate management.
  
  
  METHODS
  We report three patients who developed cardiac manifestations, revealing Churg-Strauss syndrome. The diagnosis of cardiac involvement was obtained using cardiac magnetic resonance imaging (MRI).
  
  
  RESULTS
  Two patients were males and the remaining one was a female. Presenting clinical manifestations were: cardiac failure (n=1) and retrosternal pain (n=2). Laboratory findings disclosed: high blood count of eosinophils (range: 6000-11,000/mm(3)); antineutrophil cytoplasmic antibodies were positive in a single patient. Cardiac MRI demonstrated: (1) late gadolinium enhancement (n=3), involving mainly the apical and mid-cavity left ventricular segments; (2) impaired left ventricular function (n=2), mean left ventricular ejection fraction being: 51%; and (3) pericardial effusion (n=3). Outcome was favourable after institution of combined therapy with prednisone and cyclophosphamide (n=2); one patient also underwent plasma exchanges.
  
  
  CONCLUSIONS
  Our case series underlines that MRI is a helpful tool in the diagnosis of Churg-Strauss syndrome-related cardiac complications. We further suggest that clinical assessment of patients with Churg-Strauss syndrome should include cardiac MRI, in order to detect cardiac involvement at an early stage; indeed, because cardiac manifestations are predictive factors of poor prognosis, diagnosis at early stages of cardiac involvement may result in improvement of patients management.
authors.affiliation: Département de médecine interne, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Sauvetre
authors.forename: J
authors.initials: J
authors.lastname: Fares
authors.forename: J
authors.initials: J
authors.lastname: Caudron
authors.forename: J-N
authors.initials: JN
authors.lastname: Dacher
authors.forename: N
authors.initials: N
authors.lastname: Girszyn
authors.forename: A
authors.initials: A
authors.lastname: Daragon
authors.forename: H
authors.initials: H
authors.lastname: Levesque
authors.forename: I
authors.initials: I
authors.lastname: Marie
mesh_terms: D000368:Aged; D015267:Churg-Strauss Syndrome / Q000150:complications*; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged