Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy.
OBJECTIVE
To report 3 patients who developed anti-N-methyl-d-aspartate receptor encephalitis during pregnancy.


METHODS
Case reports.


METHODS
University hospitals. Patients Three young women developed at 14, 8, and 17 weeks of gestation acute change of behavior, prominent psychiatric symptoms, progressive decrease of consciousness, seizures, dyskinesias, and autonomic dysfunction.


METHODS
Clinical, radiological, and immunological findings.


RESULTS
The 3 patients had cerebrospinal fluid pleocytosis, normal magnetic resonance imaging, and electroencephalogram showing slow activity. All had higher antibody titers in cerebrospinal fluid than in serum and 2 had ovarian teratomas that were removed. The pregnancy was terminated in 1 patient with recurrent bilateral teratomas. All patients had substantial neurological recoveries, and the 2 newborns were normal. Results of extensive antibody testing in 1 of the babies were negative.


CONCLUSIONS
The current study shows that anti-NMDAR encephalitis during pregnancy can have a good outcome for the mother and newborn.
Kumar
Monisha A
MA
Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA.
Jain
Ankit
A
Dechant
Valerie E
VE
Saito
Tsukasa
T
Rafael
Timothy
T
Aizawa
Hitoshi
H
Dysart
Kevin C
KC
Katayama
Takayuki
T
Ito
Yasuo
Y
Araki
Nobuo
N
Abe
Tatsuya
T
Balice-Gordon
Rita
R
Dalmau
Josep
J
D000906:Antibodies / Q000097:blood*; D004660:Encephalitis / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D055815:Young Adult
D000906:Antibodies; D016194:Receptors, N-Methyl-D-Aspartate