title: SEQADAPT: an adaptable system for the tracking, storage and analysis of high throughput sequencing experiments.
abstract: BACKGROUND
  High throughput sequencing has become an increasingly important tool for biological research. However, the existing software systems for managing and processing these data have not provided the flexible infrastructure that research requires.
  
  
  RESULTS
  Existing software solutions provide static and well-established algorithms in a restrictive package. However as high throughput sequencing is a rapidly evolving field, such static approaches lack the ability to readily adopt the latest advances and techniques which are often required by researchers. We have used a loosely coupled, service-oriented infrastructure to develop SeqAdapt. This system streamlines data management and allows for rapid integration of novel algorithms. Our approach also allows computational biologists to focus on developing and applying new methods instead of writing boilerplate infrastructure code.
  
  
  CONCLUSIONS
  The system is based around the Addama service architecture and is available at our website as a demonstration web application, an installable single download and as a collection of individual customizable services.
authors.affiliation: Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA. dburdick@systemsbiology.org
authors.forename: David B
authors.initials: DB
authors.lastname: Burdick
authors.forename: Chris C
authors.initials: CC
authors.lastname: Cavnor
authors.forename: Jeremy
authors.initials: J
authors.lastname: Handcock
authors.forename: Sarah
authors.initials: S
authors.lastname: Killcoyne
authors.forename: Jake
authors.initials: J
authors.lastname: Lin
authors.forename: Bruz
authors.initials: B
authors.lastname: Marzolf
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Ramsey
authors.forename: Hector
authors.initials: H
authors.lastname: Rovira
authors.forename: Ryan
authors.initials: R
authors.lastname: Bressler
authors.forename: Ilya
authors.initials: I
authors.lastname: Shmulevich
authors.forename: John
authors.initials: J
authors.lastname: Boyle
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D020407:Internet; D017422:Sequence Analysis, DNA / Q000295:instrumentation / Q000379:methods*; D012984:Software