MCP-1: chemoattractant with a role beyond immunity: a review.
BACKGROUND
Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migration. Role of MCP-1 and its receptor CCR2 in monocyte recruitment during infection or under other inflammatory conditions is well known.


METHODS
A comprehensive literature search was conducted from the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data was assessed from books and journals that published relevant articles in this field.


RESULTS
Recent and ongoing research indicates the role of MCP-1 in various allergic conditions, immunodeficiency diseases, bone remodelling, and permeability of blood - brain barrier, atherosclerosis, nephropathies and tumors.


CONCLUSIONS
MCP-1 plays an important role in pathogenesis of various disease states and hence MCP-1 inhibition may have beneficial effects in such conditions.
Yadav
Amita
A
Department of Biochemistry, Lady Hardinge Medical College, New Delhi-110001, India.
Saini
Vandana
V
Arora
Sarika
S
D018932:Chemokine CCL2 / Q000037:antagonists & inhibitors / Q000502:physiology*; D004194:Disease / Q000209:etiology; D016503:Drug Delivery Systems; D006801:Humans; D007109:Immunity; D054390:Receptors, CCR2 / Q000502:physiology
D018932:Chemokine CCL2; D054390:Receptors, CCR2