Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide.
Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and antiviral activities. Their precursors were similarly evaluated.
González
Miguel A
MA
Departamento de Química Orgánica, Universidad de Valencia, Dr Moliner 50, E-46100 Burjassot, Valencia, Spain. miguel.a.gonzalez@uv.es
Mancebo-Aracil
Juan
J
Tangarife-Castaño
Veronica
V
Agudelo-Goméz
Lee
L
Zapata
Bibiana
B
Mesa-Arango
Ana
A
Betancur-Galvis
Liliana
L
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D014709:Vero Cells
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004224:Diterpenes; C553742:labdadienedial; C109395:sclareolide