Inhibitors of osteoclastogenesis from Lawsonia inermis leaves.
Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-kappaB ligand-induced osteoclast formation in murine bone-marrow macrophages.
Cuong
Nguyen Xuan
NX
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam.
Nhiem
Nguyen Xuan
NX
Thao
Nguyen Phuong
NP
Nam
Nguyen Hoai
NH
Dat
Nguyen Tien
NT
Anh
Hoang Le Tuan
Hle T
Huong
Le Mai
le M
Kiem
Phan Van
PV
Minh
Chau Van
CV
Won
Ji-Hee
JH
Chung
Won-Yoon
WY
Kim
Young Ho
YH
D000818:Animals; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031564:Lawsonia Plant / Q000737:chemistry*; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D016328:NF-kappa B / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects*; D010666:Phenylpropionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry
D005960:Glucosides; D016328:NF-kappa B; D010666:Phenylpropionates; C553336:lawsoniaside A; C553337:lawsoniaside B; D010696:Phloroglucinol