title: Self-assembled monolayers of silver nanoparticles firmly grafted on glass surfaces: low Ag+ release for an efficient antibacterial activity.
abstract: A two-step, easy synthetic strategy in solution has been optimized to prepare authentic monolayers of silver nanoparticles (NP) on MPTS-modified glass surfaces, that were investigated by AFM imaging and by quantitative silver determination techniques. NP in the monolayers remain firmly grafted (i.e. not released) when the surfaces are exposed to air, water or in the physiological conditions mimicked by phosphate saline buffer, as UV-Vis spectroscopy and AFM studies demonstrate. About 15% silver release as Ag(+) ions has been found after 15days when the surfaces are exposed to water. The released silver cations are responsible of an efficient local microbicidal activity against Escherichia coli and Staphylococcus aureus bacterial strains.
authors.affiliation: Laboratorio di Nanochimica, Dipartimento di Chimica Generale, Università di Pavia, viale Taramelli 12-27100 Pavia, Italy. piersandro.pallavicini@unipv.it
authors.forename: Piersandro
authors.initials: P
authors.lastname: Pallavicini
authors.forename: Angelo
authors.initials: A
authors.lastname: Taglietti
authors.forename: Giacomo
authors.initials: G
authors.lastname: Dacarro
authors.forename: Yuri Antonio
authors.initials: YA
authors.lastname: Diaz-Fernandez
authors.forename: Matteo
authors.initials: M
authors.lastname: Galli
authors.forename: Pietro
authors.initials: P
authors.lastname: Grisoli
authors.forename: Maddalena
authors.initials: M
authors.lastname: Patrini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Santucci De Magistris
authors.forename: Robertino
authors.initials: R
authors.lastname: Zanoni
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004355:Drug Stability; D005898:Glass / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver