title: Speed modulation of the continuous-flow total artificial heart to simulate a physiologic arterial pressure waveform.
abstract: This study demonstrated the concept of using speed modulation in a continuous-flow total artificial heart (CFTAH) to shape arterial pressure waveforms and to adjust pressure pulsatility. A programmable function generator was used to determine the optimum pulsatile speed profile. Three speed profiles [sinusoidal, rectangular, and optimized (a profile optimized for generation of a physiologic arterial pressure waveform)] were evaluated using the CFTAH mock circulatory loop. Hemodynamic parameters were recorded at average pump speeds of 2,700 rpm and a modulation cycle of 60 beats per minute. The effects of varying physiologically relevant vascular resistance and lumped compliance on the hemodynamics were assessed. The feasibility of using speed modulation to manipulate systemic arterial pressure waveforms, including a physiologic pressure waveform, was demonstrated in vitro. The additional pump power consumption needed to generate a physiologic pulsatile pressure was 16.2% of the power consumption in nonpulsatile continuous-flow mode. The induced pressure waveforms and pulse pressure were shown to be very responsive to changes in both systemic vascular resistance and arterial compliance. This system also allowed pulsatile pulmonary arterial waveform. Speed modulation in the CFTAH could enable physicians to obtain desired pressure waveforms by simple manual adjustment of speed control input waveforms.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Ohio 44195, USA.
authors.forename: Akira
authors.initials: A
authors.lastname: Shiose
authors.forename: Kathleen
authors.initials: K
authors.lastname: Nowak
authors.forename: David J
authors.initials: DJ
authors.lastname: Horvath
authors.forename: Alex L
authors.initials: AL
authors.lastname: Massiello
authors.forename: Leonard A R
authors.initials: LA
authors.lastname: Golding
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D006354:Heart, Artificial; D008955:Models, Cardiovascular; D011474:Prosthesis Design / Q000295:instrumentation*; D011673:Pulsatile Flow / Q000502:physiology*