title: Chondroprotective effects of a polycarbonate-urethane meniscal implant: histopathological results in a sheep model.
abstract: OBJECTIVE
  injury or loss of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. However, few surgical options exist for meniscal replacement. The goal of this study was to examine the ability of a non-degradable, anatomically shaped artificial meniscal implant, composed of Kevlar-reinforced polycarbonate-urethane (PCU), to prevent progressive cartilage degeneration following complete meniscectomy.
  
  
  METHODS
  the artificial meniscus was implanted in the knees of mature female sheep following total medial meniscectomy, and the animals were killed at 3- and 6-months post-surgery. Macroscopic analysis and semi-quantitative histological analysis were performed on the cartilage of the operated knee and unoperated contralateral control joint.
  
  
  RESULTS
  the PCU implants remained well secured throughout the experimental period and showed no signs of wear or changes in structural or material properties. Histological analysis showed relatively mild cartilage degeneration that was dominated by loss of proteoglycan content and cartilage structure. However, the total osteoarthritis score did not significantly differ between the control and operated knees, and there were no differences in the severity of degenerative changes between 3 and 6 months post-surgery.
  
  
  CONCLUSIONS
  current findings provide preliminary evidence for the ability of an artificial PCU meniscal implant to delay or prevent osteoarthritic changes in knee joint following complete medial meniscectomy.
authors.affiliation: Research and Development Center, Active Implants Corporation, P.O. Box 8395, 42505 Netanya, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Zur
authors.forename: Eran
authors.initials: E
authors.lastname: Linder-Ganz
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Elsner
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shani
authors.forename: Ori
authors.initials: O
authors.lastname: Brenner
authors.forename: Gabriel
authors.initials: G
authors.lastname: Agar
authors.forename: Elliott B
authors.initials: EB
authors.lastname: Hershman
authors.forename: Steven P
authors.initials: SP
authors.lastname: Arnoczky
authors.forename: Farshid
authors.initials: F
authors.lastname: Guilak
authors.forename: Avi
authors.initials: A
authors.lastname: Shterling
mesh_terms: D000818:Animals; D002358:Cartilage, Articular; D005260:Female; D006614:Hindlimb / Q000473:pathology / Q000601:surgery; D008592:Menisci, Tibial; D023421:Models, Animal; D010003:Osteoarthritis / Q000473:pathology*; D020959:Polyethylene / Q000737:chemistry; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012756:Sheep; D014520:Urethane / Q000737:chemistry
chemical_list: D014520:Urethane; D020959:Polyethylene