title: Incidence of renal replacement therapy (RRT) in the diabetic compared with the non-diabetic population in a German region, 2002-08.
abstract: BACKGROUND
  This study was conducted to estimate incidences of renal replacement therapy (RRT) in the diabetic and non-diabetic populations in Germany, as well as relative and attributable risks of RRT due to diabetes.
  
  
  METHODS
  Using the data of a regional dialysis centre (region population of 310 000), we assessed all incident RRT patients aged 30 years or older in 2002-08. We estimated sex- and age-specific and -standardized incidences of RRT in the diabetic and non-diabetic populations, which were estimated by applying diabetes prevalences from a population-based study, and relative and attributable risks due to diabetes.
  
  
  RESULTS
  Of all subjects with incident RRT (n = 544), 49.6% had diabetes. Fifty-eight percent were male, mean age (SD) was 70.3 years (11.4 years). Incidences per 100 000 person-years (standardized to the 2004 German population) in the diabetic and the non-diabetic populations were 213.7 [95% confidence interval (95% CI), 159.5-267.8] and 26.9 (95% CI, 22.5-31.3) in men and 130.2 (95% CI, 65.6-194.9) and 16.4 (95% CI, 13.5-19.3) in women, respectively. Standardized relative risks were 7.9 (5.9-10.8) in men and 8.0 (4.7-13.5) in women. There was a significant interaction between age and diabetes, with lower relative risks in higher ages. Attributable risks among diabetic individuals were 0.87 in men and women, and population-attributable risks were 0.41 and 0.35 in men and women, respectively.
  
  
  CONCLUSIONS
  In this population-based study in a German region, we found the relative risk of RRT in the estimated adult diabetic population to be 8-fold increased compared with the non-diabetic population. A high proportion of the RRT risk can be attributed to diabetes in the diabetic as well as in the whole population.
authors.affiliation: Department of Public Health, Center of Health and Society, Heinrich Heine University, Düsseldorf, Germany. andrea.icks@ddz.uni-duesseldorf.de
authors.forename: Andrea
authors.initials: A
authors.lastname: Icks
authors.forename: Burkhard
authors.initials: B
authors.lastname: Haastert
authors.forename: Jutta
authors.initials: J
authors.lastname: Genz
authors.forename: Guido
authors.initials: G
authors.lastname: Giani
authors.forename: Falk
authors.initials: F
authors.lastname: Hoffmann
authors.forename: Rudolf
authors.initials: R
authors.lastname: Trapp
authors.forename: Michael
authors.initials: M
authors.lastname: Koch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000401:mortality / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012042:Registries; D006435:Renal Dialysis; D017582:Renal Replacement Therapy; D015996:Survival Rate; D016896:Treatment Outcome