title: Burkitt's lymphoma in a young Brazilian boy.
abstract: Burkitt's lymphoma is not an uncommon malignancy in the paediatric population. It is a high-grade non-Hodgkin B-cell lymphoma which may present as endemic, sporadic and human immunodeficiency-associated subtypes. The African, or endemic, variant usually involves the maxilla and other facial bones while head and neck manifestations in sporadic Burkitt's lymphoma are rare. We described a case of oral Burkitt's lymphoma involving the right jaw in a 4-year-old boy. The patient presented with a rapidly-enlarging swelling of one month duration, toothache-like pain and radiographical appearance of 'floating teeth' in the right mandible. Incisional biopsy revealed small round tumour cells with scarce cytoplasm and multiple small nuclei interspersed by phagocytic macrophages. The tumour cells were immunopositivity for CD20 and CD10, expressed weak positivity for CD3, negative for CD5 and showed > 90% positivity for Ki-67. Tumour remission was achieved with six cycles of chemotherapy with the CHOP regime.
authors.affiliation: Faculdade de Odontologia da Universidade Paulista, campus Flamboyant Patologia Oral Diagnóstico Oral Rodovia BR, 153, Km 503, Fazenda Botafogo - CEP: 74845-090 Goiania/GO - Brazil. claudiomaranhao@hotmail.com
authors.forename: Cláudio M
authors.initials: CM
authors.lastname: Pereira
authors.forename: Ana Paula M
authors.initials: AP
authors.lastname: Lopes
authors.forename: Alexandre J
authors.initials: AJ
authors.lastname: Meneghini
authors.forename: Geisa B L
authors.initials: GB
authors.lastname: Silva
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Monteiro
authors.forename: Tessa de L
authors.initials: Tde L
authors.lastname: Botelho
mesh_terms: D018951:Antigens, CD20 / Q000096:biosynthesis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001938:Brazil; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D017252:CD3 Complex / Q000096:biosynthesis; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D015260:Neprilysin / Q000096:biosynthesis; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D017252:CD3 Complex; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D015260:Neprilysin; D011241:Prednisone