title: Clinical impact of integrated physiologic brain tumor imaging.
abstract: The development of new MRI techniques in the last two decades has provided neuroradiologists and neurosurgeons with additional noninvasive imaging tools for management and treatment of brain tumors. When coupled with standard structural MR sequences in imaging brain tumors, Blood Oxygenation Level Dependent (BOLD) functional MRI (fMRI), Perfusion Weighted Imaging (PWI) and Diffusion Tensor Imaging (DTI) provide additional physiologic information that is very useful for differential diagnosis, presurgical planning and prognosis. In this review after a brief technical description of BOLD fMRI, PWI and DTI, studies are described from the literature that have extensively validated these imaging techniques in comparison with invasive "gold standard" techniques such as intraoperative electrical cortical and subcortical stimulation mapping or biopsy. Additional studies are mentioned that demonstrate the positive impact of BOLD fMRI, PWI and DTI on brain tumor treatment and clinical outcome. In the final section an interesting clinical case treated at our institution is presented that highlights the clinical utility of this integrated physiologic brain tumor imaging approach.
authors.affiliation: Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Univ. School of Medicine, Baltimore, MD 21287, USA. jpillai1@jhmi.edu
authors.forename: Jay  J
authors.initials: J
authors.lastname: Pillai
authors.forename: Domenico
authors.initials: D
authors.lastname: Zaca
authors.forename: Asim
authors.initials: A
authors.lastname: Choudhri
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging