Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors.
A series of eight novel, highly modified mono-, di- and trisaccharide derivatives, each containing an iminoalditol moiety, has been synthesized in the quest for potential heparanase inhibitors.
Allen
Kirsty A
KA
Carbohydrate Chemistry, Industrial Research Limited, Lower Hutt, New Zealand.
Brown
Rosemary L
RL
Norris
Gillian
G
Tyler
Peter C
PC
Watt
Derek K
DK
Zubkova
Olga V
OV
D001372:Aza Compounds / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D006497:Heparan Sulfate / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D000099175:Heparanase
D001372:Aza Compounds; D004791:Enzyme Inhibitors; D005966:Glucuronidase; D006497:Heparan Sulfate; D000099175:Heparanase