title: Detection of aortic regurgitation with 64-slice multidetector computed tomography (MDCT).
abstract: OBJECTIVE
  To determine the diagnostic accuracy of 64-row multidetector cardiac computed tomography (MDCT) in detecting aortic regurgitation (AR) on prospectively acquired images with trans-thoracic echocardiography (TTE) as a reference standard.
  
  
  METHODS
  Forty-three consecutive patients underwent MDCT and TTE. AR was defined on MDCT images acquired at 75% phase of R-R interval as the lack of aortic cusps coaptation. The maximum regurgitant orifice area (ROA) was planimetered and compared to TTE.
  
  
  RESULTS
  All 29 patients with AR on TTE were correctly identified by MDCT. The sensitivity, specificity, positive predictive value, and negative predictive value of MDCT were 100%, 85.7%, 93.5%, and 100%, respectively. Sixteen, nine, and four patients were found to have mild, moderate, and severe AR on TTE, respectively. The corresponding ROA by MDCT were 3.25 +/- 1.04 mm(2), 4.16 +/- 1.19 mm(2), and 11.30 +/- 6.13 mm(2), respectively.
  
  
  CONCLUSIONS
  MDCT data acquired for the coronary artery evaluation can be used for the detection of aortic regurgitation with high diagnostic accuracy without additional scanning or radiation and can support appropriate referral for TTE.
authors.affiliation: Division of Cardiology Los Angeles Biomedical Research Institute Harbor-UCLA, Torrance, CA, USA.
authors.forename: Irfan
authors.initials: I
authors.lastname: Zeb
authors.forename: Yasmin S
authors.initials: YS
authors.lastname: Hamirani
authors.forename: Songshuo
authors.initials: S
authors.lastname: Mao
authors.forename: Hussain
authors.initials: H
authors.lastname: Isma'eel
authors.forename: Anila
authors.initials: A
authors.lastname: Saeed
authors.forename: Sudha
authors.initials: S
authors.lastname: Karnwal
authors.forename: Sameer
authors.initials: S
authors.lastname: Raina
authors.forename: Jina
authors.initials: J
authors.lastname: Chung
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography