Short-term effect of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with obstructive sleep apnea.
CONCLUSIONS
This study shows the possibility that multilevel surgery for obstructive sleep apnea (OSA) is helpful to improve the levels of pro-inflammatory cytokines and adipokines, which are related to complications of OSA.


OBJECTIVE
The effects of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with OSA were assessed.


METHODS
Fifty-one patients with OSA underwent uvulopalatopharyngoplasty and radiofrequency tongue base reduction. Body mass index (BMI), Epworth sleepiness scale (ESS) and subjective symptoms using visual analog scales were assessed at baseline and 4 weeks after treatment. Adiponectin, leptin, interleukin (IL)-6, and tumor necrosis factor (TNF)-α were measured with a LINCOplex Human Immunoassay at baseline and 4 weeks after surgical treatment.


RESULTS
Significant improvements in subjective symptoms and ESS were found at 4 weeks after multilevel surgery. No significant change in BMI was observed. Adiponectin level was significantly increased after surgical treatment. Postoperative leptin, IL-6, and TNF-α levels were significantly decreased. The percent changes of adiponectin, leptin, IL-6, and TNF-α after multilevel surgery were not significantly different among patients with mild, moderate, and severe OSA.
Eun
Young Gyu
YG
Department of Otolaryngology-Head and Neck Surgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea.
Kim
Myung Gu
MG
Kwon
Kee Hwan
KH
Shin
Seung Youp
SY
Cho
Joong Saeng
JS
Kim
Sung Wan
SW
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood*; D004598:Electrosurgery; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010160:Palate, Soft / Q000601:surgery; D017060:Patient Satisfaction; D010614:Pharynx / Q000601:surgery; D017286:Polysomnography; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery*; D014059:Tongue / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014609:Uvula / Q000601:surgery
D054392:Adipokines; D052242:Adiponectin; D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha