Influence of GABAergic inhibition on concerted activity between the ganglion cells.
In this study, the spike discharges of one subtype of bullfrog retinal ganglion cells (dimming detectors) in response to repetitive full field light-OFF stimuli were recorded using multi-electrode arrays. Two different types of concerted activity (precise synchronization and correlated activity) could be distinguished. The nearby cells with overlapped receptive field areas often fired in synchrony, whereas the correlated activity was mainly observed from remote cell pairs with separated receptive fields. After the bicuculline application, the strength of the synchronized activity was increased whereas that of the correlated activity was decreased. These results suggest that the activation of GABAA-receptor-mediated inhibitory pathways differentially modulates the concerted firing of the ganglion cells.
Jing
Wei
W
Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Liu
Wen-Zhong
WZ
Gong
Xin-Wei
XW
Gong
Hai-Qing
HQ
Liang
Pei-Ji
PJ
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology*; D018756:GABA Antagonists / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009924:Organ Culture Techniques; D010775:Photic Stimulation / Q000379:methods; D011892:Rana catesbeiana; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology; D014794:Visual Fields / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018756:GABA Antagonists; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline