Percutaneous coronary intervention results in acute increases in native and oxidized lipoprotein(a) in patients with acute coronary syndrome and stable coronary artery disease.
OBJECTIVE
To investigate possible changes of native and oxidized lipoprotein(a) [ox-Lp(a)] levels after percutaneous coronary intervention (PCI).


METHODS
Lp(a), ox-Lp(a), and Lp(a) immune complexes (IC) and autoantibody levels were studied in 111 patients with acute coronary syndrome (ACS) and 68 patients with stable coronary artery disease (CAD) before and after PCI.


RESULTS
Compared with pre-PCI, Lp(a), ox-Lp(a), and Lp(a)-IC levels acutely increased, while the autoantibody decreased in both the ACS and stable CAD patients. They all returned toward baseline by 1 to 2 days. The absolute change of ox-Lp(a) was found positively related with both the diameter of stenosis (R=0.273, P=0.004) and the number of vessel disease (R=0.312, P=0.001) in the ACS patients, while not in the stable CAD patients.


CONCLUSIONS
PCI results in acute plasma increases of ox-Lp(a) and Lp(a). Ox-Lp(a) may be present in ruptured or permeable plaques and be released into the circulation by PCI.
Wang
Jun-jun
JJ
Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China. wangjj6@jlonline.com
Zhang
Chun-ni
CN
Han
Ai-zhong
AZ
Gong
Jian-bin
JB
Li
Ke
K
D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000936:Antigen-Antibody Complex / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D017270:Lipoprotein(a)