title: Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe.
abstract: The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively).
authors.affiliation: Department of Neurology, University Hospital, Ostrava, Czech Republic. skoloudik@hotmail.com
authors.forename: David
authors.initials: D
authors.lastname: Skoloudík
authors.forename: Tána
authors.initials: T
authors.lastname: Fadrná
authors.forename: Martin
authors.initials: M
authors.lastname: Roubec
authors.forename: Michal
authors.initials: M
authors.lastname: Bar
authors.forename: Ondrej
authors.initials: O
authors.lastname: Zapletal
authors.forename: Jirí
authors.initials: J
authors.lastname: Blatný
authors.forename: Katerina
authors.initials: K
authors.lastname: Langová
authors.forename: Petr
authors.initials: P
authors.lastname: Bardon
authors.forename: Daniel
authors.initials: D
authors.lastname: Sanák
authors.forename: Petr
authors.initials: P
authors.lastname: Kanovský
authors.forename: Roman
authors.initials: R
authors.lastname: Herzig
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000528:radiation effects*; D004453:Echoencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013010:Sonication / Q000295:instrumentation*; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods; D055815:Young Adult