title: Role of glutathione S-transferase Mu-1 (GSTM1) polymorphism in oligospermic infertile males.
abstract: The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Forty-two men with infertility and 43 fertile men were recruited for this study. GSTM1 gene was analysed using PCR technique. The frequency of GSTM1 null (-) genotype was observed to be 45.2% in infertile men as against 20.09% in fertile men. Subjects with the GSTM1 null genotype had lower sperm concentrations and motility when compared with the subjects with GSTM1-positive genotype in both the groups. This study shows that the frequency of GSTM1 null (-) genotype is significantly high in infertile males when compared with the frequency in fertile males (OR = 0.32, P = 0.017, 95% CI = 0.124-0.831).
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, India. vanigt@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Tirumala Vani
authors.forename: N
authors.initials: N
authors.lastname: Mukesh
authors.forename: B
authors.initials: B
authors.lastname: Siva Prasad
authors.forename: P
authors.initials: P
authors.lastname: Rama Devi
authors.forename: M
authors.initials: M
authors.lastname: Hema Prasad
authors.forename: P
authors.initials: P
authors.lastname: Usha Rani
authors.forename: P
authors.initials: P
authors.lastname: Pardhanandana Reddy
mesh_terms: D000328:Adult; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007194:India; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000235:genetics*; D011110:Polymorphism, Genetic; D013076:Sperm Count; D013081:Sperm Motility
chemical_list: D005982:Glutathione Transferase