title: Complexation of tocotrienol with gamma-cyclodextrin enhances intestinal absorption of tocotrienol in rats.
abstract: To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.
authors.affiliation: Department of Nutritional Sciences, Nagoya University of Arts and Sciences. saiko@nuas.ac.jp
authors.forename: Saiko
authors.initials: S
authors.lastname: Ikeda
authors.forename: Tomono
authors.initials: T
authors.lastname: Uchida
authors.forename: Tomio
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Uekaji
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakata
authors.forename: Keiji
authors.initials: K
authors.lastname: Terao
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yano
mesh_terms: D000818:Animals; D001682:Biological Availability; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D024508:Tocotrienols / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D024508:Tocotrienols; D014280:Triglycerides; D047408:gamma-Cyclodextrins