Protein folding simulations of 2D HP model by the genetic algorithm based on optimal secondary structures.
In this paper, based on the evolutionary Monte Carlo (EMC) algorithm, we have made four points of ameliorations and propose a so-called genetic algorithm based on optimal secondary structure (GAOSS) method to predict efficiently the protein folding conformations in the two-dimensional hydrophobic-hydrophilic (2D HP) model. Nine benchmarks are tested to verify the effectiveness of the proposed approach and the results show that for the listed benchmarks GAOSS can find the best solutions so far. It means that reasonable, effective and compact secondary structures (SSs) can avoid blind searches and can reduce time consuming significantly. On the other hand, as examples, we discuss the diversity of protein GSC for the 24-mer and 85-mer sequences. Several GSCs have been found by GAOSS and some of the conformations are quite different from each other. It would be useful for the designing of protein molecules. GAOSS would be an efficient tool for the protein structure predictions (PSP).
Huang
Chenhua
C
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Zhongshan Road, Guangzhou 510631, China.
Yang
Xiangbo
X
He
Zhihong
Z
D000465:Algorithms; D003198:Computer Simulation; D057927:Hydrophobic and Hydrophilic Interactions; D009010:Monte Carlo Method; D017510:Protein Folding; D017433:Protein Structure, Secondary; D055672:Static Electricity