title: Macrophages and kidney transplantation.
abstract: Macrophages are present within the transplanted kidney in varying numbers throughout its lifespan. Because of their prominence during acute rejection episodes, macrophages traditionally have been viewed as contributors to T-cell-directed graft injury. With growing appreciation of macrophage biology, it has become evident that different types of macrophages exist within the kidney, subserving a range of functions that include promotion or attenuation of inflammation, participation in innate and adaptive immune responses, and mediation of tissue injury and fibrosis, as well as tissue repair. A deeper understanding of how macrophages accumulate within the kidney and of what factors control their differentiation and function may identify novel therapeutic targets in transplantation.
authors.affiliation: Collaborative Transplantation Laboratory, Sydney Medical School, University of Sydney, New South Wales, Australia.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Chadban
authors.forename: Huiling
authors.initials: H
authors.lastname: Wu
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hughes
mesh_terms: D000208:Acute Disease; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D009393:Nephritis / Q000276:immunology; D010641:Phenotype; D011183:Postoperative Complications / Q000276:immunology; D015427:Reperfusion Injury / Q000276:immunology