VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights.
Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (IR LD/VUV PIMS) and theoretical calculations. Mass spectra of the two drugs were measured at various photon energies. Fragment ions were gradually produced as photon energy increases. The structural assignment of the dominant fragment ions was supported by the results from a commercial electron impact time-of-flight mass spectrometer (EI-TOF MS). Primary fragmentation pathways were established from experimental observations combining with theoretical calculations. Methyl radical elimination is a common fragmentation pathway for two analytes. However, for propyphenazone cation, isopropyl group elimination to form antipyrine cation is another competitive pathway.
Deng
Liulin
L
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230029, PR China.
Zhang
Lidong
L
Guo
Huijun
H
Jia
Liangyuan
L
Pan
Yang
Y
Yin
Hao
H
Qi
Fei
F
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods*; D008958:Models, Molecular; D017785:Photons
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007477:Ions; C009077:propyphenazone; D000983:Antipyrine