title: CD200 receptors are differentially expressed and modulated by minocycline in the brain during Trypanosoma brucei infection.
abstract: Infection with Trypanosoma brucei, which causes African trypanosomiasis, activates microglia, which are constitutively maintained in a quiescent state through CD200-CD200 receptor interactions. C57BL/6 mice have one inhibitory receptor, CD200R and three activating members, CD200 receptor-like (RL)a-c. Infection increased MAC-1 (microglia marker), CD200RLa and CD200RLb, but not CD200, CD200R or CD200RLc, transcript levels in the brains. Minocycline treatment inhibited the infection-induced elevation of MAC-1 and CD200RLa transcripts, but had no significant effect on CD200 or the other receptors. This suggests that CD200RLa might play a role in microglia/macrophage activation during trypanosome infection.
authors.affiliation: Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait. masocha@hsc.edu.kw
authors.forename: Willias
authors.initials: W
authors.lastname: Masocha
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology; D016177:Macrophage-1 Antigen / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008911:Minocycline / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000382:microbiology; D018709:Statistics, Nonparametric; D013997:Time Factors; D014346:Trypanosoma brucei brucei / Q000472:pathogenicity; D014352:Trypanosomiasis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D015703:Antigens, CD; C492346:CD200 receptor, mouse; D016177:Macrophage-1 Antigen; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D008911:Minocycline; C042739:antigens, CD200