title: Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
authors.affiliation: Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD UK. pmoneill@liverpool.ac.uk
authors.forename: Paul M
authors.initials: PM
authors.lastname: O'Neill
authors.forename: Richard K
authors.initials: RK
authors.lastname: Amewu
authors.forename: Gemma L
authors.initials: GL
authors.lastname: Nixon
authors.forename: Fatima
authors.initials: F
authors.lastname: Bousejra ElGarah
authors.forename: Mathirut
authors.initials: M
authors.lastname: Mungthin
authors.forename: James
authors.initials: J
authors.lastname: Chadwick
authors.forename: Alison E
authors.initials: AE
authors.lastname: Shone
authors.forename: Livia
authors.initials: L
authors.lastname: Vivas
authors.forename: Hollie
authors.initials: H
authors.lastname: Lander
authors.forename: Victoria
authors.initials: V
authors.lastname: Barton
authors.forename: Sant
authors.initials: S
authors.lastname: Muangnoicharoen
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Bray
authors.forename: Jill
authors.initials: J
authors.lastname: Davies
authors.forename: B Kevin
authors.initials: BK
authors.lastname: Park
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Michael
authors.initials: M
authors.lastname: Preschel
authors.forename: Kesheng
authors.initials: K
authors.lastname: Zhang
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Ward
mesh_terms: D000478:Alkylation; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D010963:Plasmodium falciparum / Q000187:drug effects / Q000302:isolation & purification; D054852:Small Molecule Libraries / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D045568:Tetraoxanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C554719:RKA 182; D054852:Small Molecule Libraries; D013141:Spiro Compounds; D045568:Tetraoxanes