Corneal squamous cell carcinoma in two dogs.
OBJECTIVE
To report two cases of corneal squamous cell carcinoma (SCC) in dogs.


METHODS
Corneal tumors were resected by superficial keratectomy in two cases. Immunohistochemistry of the corneal tissues was performed using anti-p53 antibody.


RESULTS
The prominent features of the cases were a clinical history of pigmentary keratitis and chronic keratitis. In each case, a corneal mass was surgically removed with a superficial keratectomy and histologically diagnosed as corneal SCC. Both masses were negative for p53. To reduce chronic corneal irritation, 0.1% hyaluronate sodium ophthalmic solution was applied. After more than 15 months of postsurgical follow-up there has been no recurrence of either neoplasm.


CONCLUSIONS
Chronic corneal irritation was suspected as the primary etiology for the corneal SCC. Appropriate surgical removal of the mass and subsequent conservative treatment for keratitis provided effective therapy in these two cases.
Takiyama
Naoaki
N
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-8510, Japan. takiyama.naoaki@nihon-u.ac.jp
Terasaki
Eri
E
Uechi
Masami
M
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D003315:Cornea / Q000473:pathology / Q000601:surgery*; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D005134:Eye Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D005260:Female