title: [Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis].
abstract: Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sena
authors.initials: S
authors.lastname: Hwang
authors.forename: Do Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Minju
authors.initials: M
authors.lastname: Kim
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Chon
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Young-Nyun
authors.initials: YN
authors.lastname: Park
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Ahn
authors.forename: Kwang-Hyub
authors.initials: KH
authors.lastname: Han
authors.forename: Chae Yoon
authors.initials: CY
authors.lastname: Chon
mesh_terms: D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D011169:Portal Vein; D020151:Protein C Deficiency / Q000150:complications*; D018455:Protein S Deficiency / Q000150:complications*; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult