title: The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years.
abstract: BACKGROUND
  The Sydney Memory and Ageing Study (Sydney MAS) was initiated in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.
  
  
  METHODS
  Non-demented community-dwelling individuals (N = 1037) aged 70-90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 554 individuals, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The cohort is to be followed up with brief telephone reviews annually, and detailed assessments biannually.
  
  
  RESULTS
  This is a generally well-functioning cohort mostly living in private homes and rating their health as being better than average, although vascular risk factors are common. Most (95.5%) participants or their informants identified a cognitive difficulty, and 43.5% had impairment on at least one neuropsychological test. MCI criteria were met by 34.8%; with 19.3% qualifying for amnestic MCI, whereas 15.5% had non-amnestic MCI; 1.6% had impairment on neuropsychological test performance but no subjective complaints; and 5.8% could not be classified. The rate of MCI was 30.9% in the youngest (70-75) and 39.1% in the oldest (85-90) age bands. Rates of depression and anxiety were 7.1% and 6.9% respectively.
  
  
  CONCLUSIONS
  Cognitive complaints are common in the elderly, and nearly one in three meet criteria for MCI. Longitudinal follow-up of this cohort will delineate the progression of complaints and objective cognitive impairment, and the determinants of such change.
authors.affiliation: Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia. p.sachdev@unsw.edu.au
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
authors.forename: Simone
authors.initials: S
authors.lastname: Reppermund
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Kochan
authors.forename: Julian N
authors.initials: JN
authors.lastname: Trollor
authors.forename: Brian
authors.initials: B
authors.lastname: Draper
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Slavin
authors.forename: John
authors.initials: J
authors.lastname: Crawford
authors.forename: Kristan
authors.initials: K
authors.lastname: Kang
authors.forename: G Anthony
authors.initials: GA
authors.lastname: Broe
authors.forename: Karen A
authors.initials: KA
authors.lastname: Mather
authors.forename: Ora
authors.initials: O
authors.lastname: Lux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000647:Amnesia / Q000453:epidemiology* / Q000473:pathology / Q000523:psychology; D001007:Anxiety / Q000453:epidemiology* / Q000473:pathology / Q000523:psychology; D001315:Australia / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology* / Q000473:pathology / Q000523:psychology; D003863:Depression / Q000453:epidemiology* / Q000473:pathology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors