title: Assessment of multiple task activation and reproducibility in patients with benign and low-grade neoplasm.
abstract: Twenty-four patients with proven benign and low-grade brain neoplasms each performed two iterations of four fMRI paradigms: language (word generation), primary and association auditory (text listening), upper limb fine motor control (alternating-limb bilateral finger tapping), and primary visual perception (reversing checkerboard). Activation clusters with varying thresholds were generated for each scan and used to calculate reproducibility parameters: Difference in the Center of Mass (COM) location, R(size), and R(overlap). The average difference in the COM, R(size), and R(overlap) values ranged from 1.70 +/- 0.53 mm -10.60 +/- 3.21 mm, 0.6 +/- 0.04-0.90 +/- 0.05 and 0.23 +/- 0.12 -1 +/- 0.16 respectively for all tasks. These values are within the range of, or higher than, previously published reports on fMRI test-retest precision. FMRI is indicated to be a noninvasive tool with acceptable reproducibility measures for assessing the localizations of multiple language and sensorimotor functions in patients scheduled for radiotherapy treatment.
authors.affiliation: Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA. mckinsey@wisc.edu
authors.forename: R D
authors.initials: RD
authors.lastname: McKinsey
authors.forename: C H
authors.initials: CH
authors.lastname: Moritz
authors.forename: M E
authors.initials: ME
authors.lastname: Meyerand
authors.forename: W A
authors.initials: WA
authors.lastname: Tomé
mesh_terms: D001307:Auditory Perception; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015203:Reproducibility of Results