title: Design, synthesis, docking and antitumor activity of quinazolino [3, 4-a] thieno [3, 2-d] pyrimidin-8-one derivatives.
abstract: Several novel quinazolino [3, 4-a] thieno [3, 2-d] pyrimidin-8-one derivatives were synthesized. All of the compounds were determined against MiaPaCa2 and DU145 cells in vitro, and the crystal structures of analog 8 and 20 in the active site of the EGFR complexes were presented. The entire compounds had been identified by 1HNMR, 13CNMR, IR, MS and EA.
authors.forename: Youguang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Wu
authors.forename: Bai
authors.initials: B
authors.lastname: Xue
authors.forename: Mingdong
authors.initials: M
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Ji
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D020134:Catalytic Domain; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D066246:ErbB Receptors / Q000737:chemistry; D006801:Humans; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines; D066246:ErbB Receptors