Erythema multiforme photoinduced by statins.
We report two cases of systemic photosensitivity induced by simvastatin and pravastatin that presented as photodistributed erythema multiforme. One of them occurred in a 75-year-old woman who had been suffering recurrent eruptions following sun exposures over a period of 12 years. The other patient was a 54-year-old man who had a 1-week history of pruritic lesions on the face and the hands. They had no history of herpes simplex virus infection. In both cases, the close temporal relationship between drug ingestion and onset of the conditions suggested statin-induced photosensitivity. The diagnosis was confirmed by the marked reduction of UVB-MED or both UVA and UVB-MED while taking the drug and its normalization after discontinuing the statin intake.
Rodríguez-Pazos
Laura
L
Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, Spain. jaime.toribio@usc.es
Sánchez-Aguilar
Dolores
D
Rodríguez-Granados
María Teresa
MT
Pereiro-Ferreirós
María Mercedes
MM
Toribio
Jaime
J
D000368:Aged; D004892:Erythema Multiforme / Q000139:chemically induced / Q000209:etiology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays / Q000009:adverse effects*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors