title: Antioxidant activity of Nepeta nuda L. ssp. nuda essential oil rich in nepetalactones from Greece.
abstract: Essential oils from air-dried leaves and verticillasters of Nepeta nuda ssp. nuda from Greece were analyzed by means of gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. The dominant constituent in the verticillaster oils was 4aα,7α,7aß-nepetalactone (75.7%). The main metabolites of the leaf oil were 1,8-cineole (16.7%), 4aα,7α,7aß-nepetalactone (24.7%), and caryophyllene oxide (16.3%). The oils were examined for their antioxidant activity. Neutralization of stable 2,2-diphenyl-1-picrylhydrazyl radical ranged from 10.83% (2.50 μg/mL) to 58.64% (50.00 μg/mL) for verticillaster oil and from 6.25% (2.50 μg/mL) to 57.79% (50.00 μg/mL) for leaf oil. The essential oil from verticillasters had significant effects on lipid peroxidation (in the range of 41.18-59.23%), compared to tert-butylated hydroxytoluene (37.04%). In contrast, the essential oil from leaves exhibited pro-oxidant activity at the highest concentration applied.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Gkinis
authors.forename: Biljana
authors.initials: B
authors.lastname: Bozin
authors.forename: Neda
authors.initials: N
authors.lastname: Mimica-Dukic
authors.forename: Olga
authors.initials: O
authors.lastname: Tzakou
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002849:Chromatography, Gas; D000081004:Cyclopentane Monoterpenes; D003517:Cyclopentanes / Q000032:analysis*; D035264:Flowers / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006115:Greece; D015227:Lipid Peroxidation / Q000187:drug effects; D027521:Nepeta / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D011753:Pyrones / Q000032:analysis*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D000081004:Cyclopentane Monoterpenes; D003517:Cyclopentanes; D009822:Oils, Volatile; D010851:Picrates; D011753:Pyrones; D002084:Butylated Hydroxytoluene; C115644:nepetalactone; C004931:1,1-diphenyl-2-picrylhydrazyl