title: Helicobacter pylori bacterial ghost containing recombinant Omp18 as a putative vaccine.
abstract: Helicobacter pylori bacterial ghosts, HPBG, were generated by PhiX174 mechanism and loaded with recombinant Omp18, which were then applied in therapeutic immunization of Hp-infected C57BL/6 mice. Recombinant Omp18 loaded HPBG plus cholera toxin stimulated serum anti-Hp and Omp18-specific antibodies which resulted in significant reduction of gastric Hp colonization (P<0.05).
authors.affiliation: Biotechnology Research Center, Pasteur Institute of Iran, Tehran.
authors.forename: Y
authors.initials: Y
authors.lastname: Talebkhan
authors.forename: M
authors.initials: M
authors.lastname: Bababeik
authors.forename: M
authors.initials: M
authors.lastname: Esmaeili
authors.forename: A
authors.initials: A
authors.lastname: Oghalaei
authors.forename: S
authors.initials: S
authors.lastname: Saberi
authors.forename: Z
authors.initials: Z
authors.lastname: Karimi
authors.forename: N
authors.initials: N
authors.lastname: Afkhami
authors.forename: M
authors.initials: M
authors.lastname: Mohammadi
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D005260:Female; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines