title: Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors.
abstract: Aptamer functionalized addressable SWNT-film arrays between cantilever electrodes were successfully developed for biosensor applications. Dielectrophoretically aligned SWNT suspended films made possible highly specific and rapid detection of target proteins with a large binding surface area. Thrombin aptamer immobilized SWNT-film FET biosensor resulted in a real-time, label-free, and electrical detection of thrombin molecules down to a concentration of ca. 7 pM with a step-wise rapid response time of several seconds.
authors.affiliation: Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
authors.forename: Taechang
authors.initials: T
authors.lastname: An
authors.forename: Ki Su
authors.initials: KS
authors.lastname: Kim
authors.forename: Sei Kwang
authors.initials: SK
authors.lastname: Hahn
authors.forename: Geunbae
authors.initials: G
authors.lastname: Lim
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D004574:Electromagnetic Fields; D004586:Electrophoresis / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D011506:Proteins; D042461:Vascular Endothelial Growth Factor A; C081676:thrombin aptamer