title: Systemic photosensitivity due to a contraceptive patch.
abstract: Hormonal contraceptives are a known but rarely reported cause of photosensitivity. A 35-year-old female developed several episodes of a prurigionous papulovesicular eruption located on sun-exposed areas that resolved without scarring in days. She had been using a transdermal contraceptive (EVRA: norelgestromin and ethinyloestradiol) for 3 years, and once it was stopped, the patient became asymptomatic. She had another episode after the use of oral contraceptives (YAZ: ethinyloestradiol and drospirenone). The biopsy of the lesions showed a spongiotic dermatitis. Minimal erythema dose was diminished when the patient was using EVRA and YAZ and became normal when they were withdrawn. Phototesting with UVA, photopatch testing and blood porphyrins were normal. Antinuclear antibodies were 1/80 initially and were 1/320 6 months later. Anti-deoxyribonucleic acid antibodies, extractable nuclear antigens, anti Ro and Anti La were negative and no systemic symptoms had developed. When all hormonal contraceptives were stopped, the patient became asymptomatic. We report a case of systemic photosensitivity induced by the contraceptive patch. To the best of our knowledge, no other cases induced by transdermal contraceptives have been reported previously.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain. sil.gomez@gmail.com
authors.forename: Silvia
authors.initials: S
authors.lastname: Gómez-Bernal
authors.forename: Manuel
authors.initials: M
authors.lastname: Loureiro
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Rodríguez-Granados
authors.forename: Jaime
authors.initials: J
authors.lastname: Toribio
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003270:Contraceptive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010787:Photosensitivity Disorders / Q000209:etiology* / Q000276:immunology
chemical_list: D003270:Contraceptive Agents