title: Cardiovascular effects of intravenous gadolinium administration to anaesthetized dogs undergoing magnetic resonance imaging.
abstract: OBJECTIVE
  To assess changes in heart rate and arterial blood pressure following intravenous (IV) gadolinium-based contrast media administration to sevoflurane-anaesthetized dogs undergoing magnetic resonance imaging (MRI).
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Fifty client-owned dogs (31 male, 19 female; aged 6-156 months; weighing 4.2-45.4 kg; ASA 2-3).
  
  
  METHODS
  Heart rate and oscillometric blood pressures (systolic, mean and diastolic) were recorded at 10 minutes, 5 minutes and immediately pre-administration of IV gadolinium contrast medium (time 0), then at 1, 2, 3, 5 and 10 minutes post-gadolinium administration. Repeated measures anova was used to compare cardiovascular variables pre and post-gadolinium administration. Significance was set at p < 0.05.
  
  
  RESULTS
  There were no significant changes in cardiovascular variables following the IV administration of gadolinium.
  
  
  CONCLUSIONS
  Administration IV of gadolinium-based contrast media was not associated with adverse cardiovascular effects in these sevoflurane-anaesthetized dogs undergoing MRI.
authors.affiliation: Chestergates Referral Hospital, Unit F, Telford Court, Chestergates, Chester, UK. alastair.mair@yahoo.co.uk
authors.forename: Alastair R
authors.initials: AR
authors.lastname: Mair
authors.forename: Jenny
authors.initials: J
authors.lastname: Woolley
authors.forename: Miguel
authors.initials: M
authors.lastname: Martinez
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary; D018685:Anesthetics, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D008738:Methyl Ethers; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D003287:Contrast Media; D008738:Methyl Ethers; D000077149:Sevoflurane; D019786:Gadolinium DTPA