Recommendations for the selection, treatment, and management of patients utilizing natalizumab therapy for multiple sclerosis.
Natalizumab is an integrin receptor antagonist indicated for the treatment of multiple sclerosis (MS). Natalizumab is indicated as monotherapy in patients who have had an inadequate response to other forms of MS treatment and is not recommended as first-line treatment because of the potential for serious adverse events associated with its use. It is critical for both physicians and patients to understand the benefits as well as the potential risks of treating MS with natalizumab. One of the serious adverse events associated with treatment with natalizumab is the possibility of developing progressive multifocal leukoencephalopathy (PML). Physicians and patients must weigh the benefits of treatment against the possibility of developing PML before undergoing treatment. Proper clinical vigilance, via the Tysabri Outreach: Unified Commitment to Health (TOUCH) Prescribing Program, is currently the best method to minimize the risk of PML, associated with natalizumab therapy.
Foley
John
J
Rocky Mountain Multiple Sclerosis Clinic, Salt Lake City, UT 84103, USA. ldjfoley@gmail.com
D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D002986:Clinical Trials as Topic; D018450:Disease Progression; D016903:Drug Monitoring; D006801:Humans; D039001:Integrin alpha Chains / Q000037:antagonists & inhibitors*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced; D009103:Multiple Sclerosis / Q000188:drug therapy*; D000069442:Natalizumab; D018579:Patient Selection; D012307:Risk Factors
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D039001:Integrin alpha Chains; D000069442:Natalizumab