title: Robert Koch redux: malaria immunology in Papua New Guinea.
abstract: Over a century ago, the malaria expedition of the brilliant microbiologist Robert Koch to the Dutch East Indies (Indonesia) and German New Guinea (now Papua New Guinea, or PNG), resulted in profound observations that are still central to our current understanding of the epidemiology and acquisition of immunity to the malaria parasite Plasmodium. The tradition of malaria research in PNG pioneered by Koch continues to this day, with a number of recent studies still continuing to elucidate his original concepts and hypotheses. These include age and exposure-related acquisition of immunity, species-specific and cross-species immunity, correlates of protective immunity and determining the prospects for anti-malaria vaccines.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.
authors.forename: D I
authors.initials: DI
authors.lastname: Stanisic
authors.forename: I
authors.initials: I
authors.lastname: Mueller
authors.forename: I
authors.initials: I
authors.lastname: Betuela
authors.forename: P
authors.initials: P
authors.lastname: Siba
authors.forename: L
authors.initials: L
authors.lastname: Schofield
mesh_terms: D035843:Biomedical Research / Q000639:trends; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008288:Malaria / Q000453:epidemiology* / Q000266:history / Q000276:immunology* / Q000517:prevention & control; D017780:Malaria Vaccines / Q000276:immunology; D010219:Papua New Guinea / Q000453:epidemiology; D010961:Plasmodium / Q000276:immunology*
chemical_list: D017780:Malaria Vaccines