title: Blood flow: metalloproteases cut loose in primitive erythrocytes.
abstract: Little is known about how blood begins to flow during development. A new study shows that release of primitive blood cells in the zebrafish embryo is synchronized and mediated by a metalloprotease.
authors.affiliation: Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Tamplin
authors.forename: Leonard I
authors.initials: LI
authors.lastname: Zon
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001775:Blood Circulation; D004912:Erythrocytes / Q000201:enzymology*; D045726:Metalloproteases / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology* / Q000502:physiology
chemical_list: D045726:Metalloproteases