title: Reference serum cystatin C levels in Japanese children.
abstract: BACKGROUND
  Single measurements of serum cystatin C (cysC) concentration have generally been used to determine glomerular filtration rate (GFR) in adults. Since GFR varies to some extent among children, we attempted to determine reference serum cysC concentrations for Japanese children.
  
  
  METHODS
  Serum cysC concentrations were determined by a latex particle-enhanced turbidimetric immunoassay in children who did not present with kidney disease or infectious disease, and the relationship between age and serum cysC level was assessed.
  
  
  RESULTS
  We found that reference serum cysC levels gradually decreased during the first year after birth, thereafter becoming constant. Mean serum cysC concentration in children aged 1 year (0.76 ± 0.10 mg/L) was slightly higher than in children aged ≥2 years (0.70 ± 0.09 mg/L).
  
  
  CONCLUSIONS
  Our reference values will be applicable for screening renal function in Japanese children.
authors.affiliation: Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, Obu, Aichi, 474-8710, Japan. o_uemura@hkg.odn.ne.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Uemura
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ushijima
authors.forename: Takuhito
authors.initials: T
authors.lastname: Nagai
authors.forename: Takuji
authors.initials: T
authors.lastname: Yamada
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nabeta
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Shinkai
authors.forename: Kouichi
authors.initials: K
authors.lastname: Koike
authors.forename: Masaki
authors.initials: M
authors.lastname: Kuwabara
mesh_terms: D000293:Adolescent; D000375:Aging / Q000097:blood; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007677:Kidney Function Tests / Q000379:methods / Q000592:standards; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000592:standards; D012016:Reference Values
chemical_list: D055316:Cystatin C