title: Alternative splicing and breast cancer.
abstract: Alternative splicing is a key molecular event in the gene expression process. It allows for the synthesis of different products from the same gene, and consequently increases the complexity of the proteome encoded by a limited number of genes. Although alterations of alternative splicing are among the myriad of alterations present in tumor cells, increasing evidence indicates that cancer-associated splicing variants play an important role in tumor initiation and progression. Therefore, alternative splicing studies are opening new avenues of research in basic and translational molecular oncology.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U590, Centre Léon Bérard, Lyon, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Dutertre
authors.forename: Stephan
authors.initials: S
authors.lastname: Vagner
authors.forename: Didier
authors.initials: D
authors.lastname: Auboeuf
mesh_terms: D017398:Alternative Splicing; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor