title: Posterior capsule opacity as initial manifestation of metastatic cutaneous melanoma.
abstract: BACKGROUND
  Cutaneous metastatic melanoma usually is locoregional, and represents less than 5% of malignancies known to metastasize to the eye and orbit. When there is intraocular involvement, it most commonly occurs in the choroid, vitreous, and retina.
  
  
  METHODS
  We report a case of a 71-year-old woman with metastatic melanoma presenting as a pigmented posterior capsular opacity in a pseudophakic eye 14 months after excisional biopsy of an ulcerative cutaneous melanoma of the upper arm.
  
  
  RESULTS
  Histopathology confirmed the presence of melanocytic cells on the surface of the anterior lens optic and the posterior capsular surface, as well as melanophagic invasion of the trabecular meshwork. At 7 months following enucleation, there was no evidence of recurrence by either computed tomography or sequential positron emission tomography.
  
  
  CONCLUSIONS
  To our knowledge this is the first report of posterior capsular opacification serving as the initial manifestation of cutaneous metastatic melanoma. With the incidence of cutaneous melanoma on the rise, and an increasing number of cataract procedures performed annually, clinicians should be are of the different ways cutaneous metastatic melanoma may involve the intraocular structures of the eye.
authors.affiliation: Solomon Eye Physicians & Surgeons, Bowie, MD, USA. jdsolomon@hotmail.com
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Solomon
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
authors.forename: Ralph C
authors.initials: RC
authors.lastname: Eagle
mesh_terms: D000368:Aged; D058442:Capsule Opacification / Q000175:diagnosis*; D015353:Eye Enucleation; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D008545:Melanoma / Q000556:secondary*; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000000981:diagnostic imaging / Q000473:pathology*; D019591:Pseudophakia / Q000209:etiology; D012878:Skin Neoplasms / Q000473:pathology*; D014463:Ultrasonography