title: Treatment with iron of patients with heart failure with and without anemia.
abstract: Iron deficiency is a common cause of anemia in otherwise healthy individuals and plays an important role in the development of anemia within the heart failure patient population. Iron-deficient heart failure patients experience worse symptoms and are less exercise tolerant than those without iron deficiency. These symptoms may occur even before clinical anemia is evident. This article reviews studies of the benefits of the use of intravenous iron to treat iron deficiency in anemic and nonanemic heart failure patients and an overview of the physiology and pathophysiology of iron metabolism in chronic heart failure.
authors.affiliation: The Leon H. Charney Division of Cardiology, New York University School of Medicine, 530 First Avenue, Skirball- 9R, New York, NY 10016, USA.
authors.forename: Qurat-ul-ain
authors.initials: QU
authors.lastname: Jelani
authors.forename: Philipp
authors.initials: P
authors.lastname: Attanasio
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Katz
authors.forename: Stefan D
authors.initials: SD
authors.lastname: Anker
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D017079:Exercise Tolerance; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007262:Infusions, Intravenous; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D011788:Quality of Life
chemical_list: D007501:Iron