title: [Synchronous detection of T-cell clonality and FIP1L1-PDGFRA fusion gene in a hypereosinophilic syndrome].
abstract: We report a 49-year-old man suffering from chronic hypereosinophilia whose biological tests revealed a gene rearrangement between FIP1L1 and PDGFRA as well as a T-cell clonality. After 1 year of therapy with imatinib mesylate (100 mg daily), the patient was clinically asymptomatic, the fusion transcript was undetectable using RTQ-PCR and no lymphoproliferative disorders occurred. This unique combination raises the question of the physiopathology of such a grey zone hypereosinophilia and their management.
authors.affiliation: Fédération des laboratoires, HIA Sainte-Anne, BP 20545, 83041 Toulon cedex 9, France. christophe.martinaud@inserm.fr
authors.forename: C
authors.initials: C
authors.lastname: Martinaud
authors.forename: J-B
authors.initials: JB
authors.lastname: Souraud
authors.forename: J-M
authors.initials: JM
authors.lastname: Cournac
authors.forename: S
authors.initials: S
authors.lastname: Pons
authors.forename: G
authors.initials: G
authors.lastname: Ménard
authors.forename: J-P
authors.initials: JP
authors.lastname: de Jaureguiberry
authors.forename: P
authors.initials: P
authors.lastname: Brisou
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D002908:Chronic Disease; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D013601:T-Lymphocytes / Q000473:pathology*; D016896:Treatment Outcome; D039221:mRNA Cleavage and Polyadenylation Factors / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; C479818:FIP1L1 protein, human; D015514:Oncogene Proteins, Fusion; D010879:Piperazines; D011743:Pyrimidines; D039221:mRNA Cleavage and Polyadenylation Factors; D000068877:Imatinib Mesylate; D020796:Receptor, Platelet-Derived Growth Factor alpha