title: Terpioside B, a difucosyl GSL from the marine sponge Terpios sp. is a potent inhibitor of NO release.
abstract: Terpioside B (2a), a unique glycolipid containing two fucose residues in the furanose form in its pentasaccharide chain, was isolated from the marine sponge Terpios sp. Its complete stereostructure was solved by interpretation of mass spectrometric and NMR data along with CD and GG-MS analyses of its degradation products. Terpioside B is a potent inhibitor against LPS-induced NO release, and is considerably more active than simpler glycosphingolipids such as terpioside A and monoglucosylceramide.
authors.affiliation: The NeaNAT group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Costantino
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mangoni
authors.forename: Roberta
authors.initials: R
authors.lastname: Teta
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Panza
authors.forename: Angela
authors.initials: A
authors.lastname: Ianaro
mesh_terms: D000818:Animals; D002460:Cell Line; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000276:immunology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D006017:Glycolipids; D008070:Lipopolysaccharides; C553482:terpioside B; D009569:Nitric Oxide