No time to lose: workshop on circadian rhythms and metabolic disease.
The objective of the workshop was to gain a better understanding of the link between circadian rhythms and human health and disease. The impacts of circadian rhythms on metabolic gene regulation, as well as the effect of nutrient uptake and balance on the molecular components of the clock, were discussed. Topics included the neural circuitry underlying the central clock; the effect of the environment and diet on the central clock as well as peripheral, tissue-specific clocks; and the transcriptional, post-transcriptional, and post-translational (e.g., epigenomic) mechanisms through which these signals are transduced. Evidence presented during the meeting demonstrated that circadian rhythms and metabolism are intricately linked, and that disruption in these rhythms have profound consequences-many times leading to metabolic disease. The mechanisms by which circadian rhythms are maintained and the cross-talk with metabolic signaling are just beginning to be elucidated. However, the interactions between these fields and the knowledge learned will clearly have a profound impact on our understanding of metabolic disease and lead to novel therapeutic approaches in the future.
Silva
Corinne M
CM
Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. silvacm@mail.nih.gov
Sato
Sheryl
S
Margolis
Ronald N
RN
D000818:Animals; D001683:Biological Clocks; D002940:Circadian Rhythm; D006801:Humans; D008659:Metabolic Diseases / Q000503:physiopathology*