title: Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.
abstract: An efficient protocol for elaboration of the 5,6-fused 2-pyridone ring system, exploiting the tandem condensation of propiolamide and cyclic β-ketomethyl esters in water, followed by acid or base promoted intramolecular ring closure and decarboxylation, has been developed.
authors.affiliation: Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
authors.forename: Onur
authors.initials: O
authors.lastname: Atasoylu
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Beshore