Cytotoxic triterpenoids from Ganoderma lucidum.
A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them (1-6) are hitherto unknown. The structures of the latter were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed.
Cheng
Chun-Ru
CR
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Yue
Qing-Xi
QX
Wu
Zhi-Yuan
ZY
Song
Xiao-Yi
XY
Tao
Si-Jia
SJ
Wu
Xiao-Hui
XH
Xu
Ping-Ping
PP
Liu
Xuan
X
Guan
Shu-Hong
SH
Guo
De-An
DA
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D020940:Reishi / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity*
D000970:Antineoplastic Agents; D014315:Triterpenes