title: Use of in vivo insert molding to form a jellyfish valve leaflet.
abstract: We developed an in vivo insert molding technique to form tissue-derived biomaterials into the desired shape, and with sufficient strength and durability, for use in artificial organs. Molds of acrylic resin with inserted velour cloth were implanted under the skin of goats to form a circular leaflet for a jellyfish valve. The valve leaflets were successfully produced in the molds after 17-60 days. Dense connective tissue covered the velour cloth, and loose connective tissue was formed within it. Tissue was radially formed from the hole in the mold. The tissue was simultaneously formed and shrunk. It is necessary to increase the connected portion between the tissue inside and outside the mold so that the tissue can completely cover the inserted materials without shrinkage.
authors.affiliation: Kitasato University, Kanagawa, Japan. mm07021s@kitasato-u.ac.jp
authors.forename: Ayumi
authors.initials: A
authors.lastname: Kishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Isoyama
authors.forename: Itsuro
authors.initials: I
authors.lastname: Saito
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Miura
authors.forename: Hidemoto
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Akimasa
authors.initials: A
authors.lastname: Kouno
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ono
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Abe
authors.forename: Kou
authors.initials: K
authors.lastname: Imachi
authors.forename: Makoto
authors.initials: M
authors.lastname: Noshiro
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001705:Bioprosthesis; D006041:Goats; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006351:Heart Valves / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D011091:Polyesters; C020542:velour