IL-1 polymorphism and periimplantitis. A literature review.
The most important factor leading to periimplantitis with bone loss appears to be an inflammatory process due to plaque accumulation. The object of this article was to present a review of the literature on a possible correlation between IL-1 polymorphism and periimplantitis. Research was carried out in the PUBMED and WEB OF KNOWLEDGE literature databases and 27 relevant articles were found. Of these articles, 4 groups of authors came to the conclusion that no correlation exists between IL-1 polymorphism and periimplantitis. In 5 articles by 4 groups of authors, the influence of IL-1 polymorphism on periimplantitis is unclear. 9 studies prove a correlation between IL-1 polymorphism and periimplantitis, and 6 studies also document a direct linkage between gene polymorphism and periimplantitis, if certain cofactors are present. IL-1 polymorphism is frequently connected with "noninfectious periimplant bone loss". Other studies prove that the inflammatory mediators and IL-1beta were significantly elevated in the gingival crevicular fluid (GCF) of infected implants. Many studies document that IL-1 polymorphism alone cannot be considered a risk factor for bone loss, but in combination with smoking, it is closely associated with periimplant bone loss. More studies are needed to discover possible correlations between IL-1 polymorphism and periimplantitis.
Bormann
Kai-Hendrik
KH
Clinic for Oral and Maxillofacial Surgery, Medical University of Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. bormann.kai-hendrik@mh-hannover.de
Stühmer
Constantin
C
Z'Graggen
Marcel
M
Kokemöller
Horst
H
Rücker
Martin
M
Gellrich
Nils-Claudius
NC
D016301:Alveolar Bone Loss / Q000235:genetics / Q000276:immunology; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D057873:Peri-Implantitis / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide
D053583:Interleukin-1beta