title: [Clinical observation of basic fibroblast growth factor combined with topical oxygen therapy in enhancing burn wound healing].
abstract: OBJECTIVE
  To investigate the efficacy of basic fibroblast growth factor (bFGF) combined with topical oxygen therapy for deep II degree burn wounds, by comparing the effects of bFGF combined with topical oxygen therapy and bFGF with routine therapy.
  
  
  METHODS
  From February 2004 to July 2009, 85 patients with deep II degree burn wounds (117 wounds) were enrolled and divided into 4 groups randomly according to different treatments. There was no significant difference in sex, age, disease course, wound size, and wound treatment size among 4 groups (P > 0.05). In group A, 18 patients (28 wounds) were treated routinely; in group B, 23 patients (30 wounds) were treated with routine methods and topical oxygen therapy; in group C, 19 patients (25 wounds) were treated with routine methods and bFGF therapy; and in group D, 25 patients (34 wounds) were treated with routine methods and bFGF/topical oxygen therapy. Topical oxygen therapy was administered to the wound for 90 minutes per day for 3 weeks. The bFGF therapy was applied everyday (150 U/cm2) for 3 weeks.
  
  
  RESULTS
  All cases were followed up 6-12 months (9 months on average). The wound healing times in groups A, B, C, and D were (27.3 +/- 6.6), (24.2 +/- 5.8), (22.2 +/- 6.8), and (18.2 +/- 4.8) days, respectively; showing significant difference between group A and group D (P < 0.05). The wound healing rates in groups A, B, C, and D were 67.8% +/- 12.1%, 85.1% +/- 7.5%, 89.2% +/- 8.3%, and 96.1% +/- 5.6%, respectively; showing significant differences between group A and groups B, C, D (P < 0.05). The therapic effective rates in groups A, B, C, and D were 75%, 90%, 92%, and 100%, respectively; showing significant difference between group A and group D (P < 0.05). The Vancouver scar scale scoring of group D 6 months after treatment was better than that of group A (P < 0.05).
  
  
  CONCLUSIONS
  The bFGF combined with topical oxygen therapy can enhance deep II degree burn wound healing. Furthermore, the therapy method is simple and convenient.
authors.affiliation: Department of Burn and Plastic Surgery, Affiliated First Hospital, Zunyi Medical College, Zunyi Guizhou, P.R.China. nie9898@sina.com
authors.forename: Kaiyu
authors.initials: K
authors.lastname: Nie
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Li
authors.forename: Xueqin
authors.initials: X
authors.lastname: Zeng
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Sun
authors.forename: Wenhu
authors.initials: W
authors.lastname: Jin
authors.forename: Zairong
authors.initials: Z
authors.lastname: Wei
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Qi
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang
authors.forename: Dali
authors.initials: D
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
chemical_list: D016222:Fibroblast Growth Factor 2; D010100:Oxygen