title: Tyrosinase inhibitory effect of quercetin 4'-O-β-D-glucopyranoside from dried skin of red onion (Allium cepa).
abstract: In an effort to find a new whitening agent, we focused our attention on Allium cepa (red onion). Based on biologically guided fractionation using mushroom tyrosinase, quercetin 4'-O-β-D-glucopyranoside was isolated from the dried skin of A. cepa. Quercetin 4'-O-β-D-glucopyranoside showed tyrosinase inhibitory activity using L-tyrosine or L-DOPA as a substrate, with IC(50) values of 4.3 and 52.7 µM, respectively. Based on the results obtained, the dried skin of red onion possesses ingredients with potential for skin-whitening cosmetics with anti-tyrosinase activity.
authors.affiliation: Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Enos Tangke
authors.initials: ET
authors.lastname: Arung
authors.forename: Irawan
authors.initials: I
authors.lastname: Wijaya Kusuma
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Kondo
mesh_terms: D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D019697:Onions / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011794:Quercetin / Q000737:chemistry*
chemical_list: D005960:Glucosides; D010936:Plant Extracts; D011794:Quercetin; D014442:Monophenol Monooxygenase