title: Cyclosporine 0.05% to improve visual outcomes after multifocal intraocular lens implantation.
abstract: OBJECTIVE
  To evaluate the efficacy of cyclosporine 0.05% in alleviating dry-eye signs and improving visual quality after multifocal intraocular lens (IOL) implantation.
  
  
  METHODS
  Private practice and university medical center, New York, New York, USA.
  
  
  METHODS
  This randomized prospective contralaterally controlled double-masked trial comprised patients scheduled to have bilateral phacoemulsification with implantation of a refractive multifocal IOL (ReZoom). Patients received twice-daily cyclosporine 0.05% in 1 eye and an artificial tear in the other eye from 1 month before to 2 months after second-eye surgery. Outcomes were evaluated at baseline and 2 months after second-eye surgery.
  
  
  RESULTS
  The study enrolled 28 eyes of 14 patients. At baseline, there were no statistically significant between-group differences in outcome measures. Two months postoperatively, the cyclosporine group had significantly lower mean uncorrected distance visual acuity than the artificial tear group (0.11 logMAR +/- 0.03 [SD] [20/25 Snellen equivalent] versus 0.19 +/- 0.05 logMAR [20/30]; P = .045) as well as significantly lower mean corrected distance visual acuity (0.0 +/- 0.02 logMAR [20/20] versus 0.1 +/- 0.02 logMAR [20/25]; P = .005) and corneal staining scores (0.210 +/- 0.07 versus 0.645 +/- 0.18; P = .034). Treatment with cyclosporine 0.05% also improved contrast sensitivity, conjunctival staining, and tear breakup time. Significantly more patients preferred the eye treated with cyclosporine 0.05% to the eye treated with artificial tears (57.1% versus 14.3%; P = .007).
  
  
  CONCLUSIONS
  Cyclosporine 0.05% therapy reduced dry-eye signs and improved visual quality after multifocal IOL implantation.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.
authors.affiliation: Ophthalmic Consultants of Long Island, 2000 North Village Avenue, Suite 402, Rockville Centre, New York 11570, USA. eddoph@aol.com
authors.forename: Eric D
authors.initials: ED
authors.lastname: Donnenfeld
authors.forename: Renée
authors.initials: R
authors.lastname: Solomon
authors.forename: Calvin W
authors.initials: CW
authors.lastname: Roberts
authors.forename: John R
authors.initials: JR
authors.lastname: Wittpenn
authors.forename: Marguerite B
authors.initials: MB
authors.lastname: McDonald
authors.forename: Henry D
authors.initials: HD
authors.lastname: Perry
mesh_terms: D000287:Administration, Topical; D000368:Aged; D015350:Contrast Sensitivity / Q000502:physiology; D016572:Cyclosporine / Q000008:administration & dosage*; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine