title: A role for SIRT1 in the hypoxic response.
abstract: In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Scott F
authors.initials: SF
authors.lastname: Leiser
authors.forename: Matt
authors.initials: M
authors.lastname: Kaeberlein