The effect of Carum Copticum extract on acetylcholine induced contraction in isolated rat's ileum.
OBJECTIVE
There are many biological investigations for determining an effective cure for the dysfunction of gastrointestinal tracts, using herbal medicine. It has been reported that Carum Copticum is a bactericidal agent and possesses anticholinergic, antihistaminic and b-adrenergic stimulatory effects in some tissues. However, these effects of Carum Copticum on mechanical activities of isolated intestine are not clearly identified yet. The present study has been designed to find out the specific effects of Carum Copticum on mechanical activity of isolated rat's ileum.


METHODS
In this study rat's ileum contraction was recorded through an isolated tissue chamber in an organ bath by using isotonic transducer and oscillographic device. The effect of Carum Copticum extract on acetylcholine induced contraction in isolated rat's ileum was evaluated.


RESULTS
Our findings showed that 1% aqueous extract of Carum Copticum reduces the basal contractile activity of rat's ileum. The extract also reduced acetylcholine induced contraction to 40% of its maximum response. The inhibitory action of Carum Copticum extract on acetylcholine induced contraction was similar but slower than that of atropine sulfate.


CONCLUSIONS
The results of this study showed an inhibitory effect of Carum Copticum extract on acetylcholine induced contraction in rat's ileum.
Hejazian-Y
Seyed Hassan
SH
Herbal Medicine Research Center, School of Medicine, Shahid Sadughi University of Medical Sciences and Health Services, Yazd, Iran.
Dashti-R
Mohammad Hossein
MH
Mahdavi
Seyed Majid
SM
Qureshi
Masood Anvar
MA
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D029974:Carum / Q000737:chemistry*; D007082:Ileum / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D010936:Plant Extracts; D000109:Acetylcholine