Searching for functional SNPs or rare variants in exonic regions of DRD3 in risperidone-treated patients.
Previously one intronic DRD3 SNP, rs167771, was associated with risperidone-induced extrapyramidal side-effects (EPS). The aim of the present study was to search hitherto unidentified common functional variants or rare variants, in DRD3 associated with risperidone-induced EPS. 126 subjects treated with risperidone participated in this study. We sequenced the seven exons of DRD3. After sequencing we localized five dbSNPs and four new rare variants. None of the dSNPs or rare variants seems to be functional after bioinformatics analysis. Our results suggest that, rather than exonic regions, regulatory regions and introns could be related to the associations reported for DRD3 and the incidence of locomotor side-effects.
Gassó
Patricia
P
Dept. of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E-08036 Barcelona, Spain.
Mas
Sergi
S
Oliveira
Cristina
C
Bioque
Miquel
M
Parellada
Eduard
E
Bernardo
Miquel
M
Trias
Gemma
G
Comeche
Joaquim
J
Lafuente
Amalia
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018492:Dopamine Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D005091:Exons; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D013030:Spain; D055815:Young Adult
D014150:Antipsychotic Agents; C493593:DRD3 protein, human; D018492:Dopamine Antagonists; D050637:Receptors, Dopamine D3; D018967:Risperidone