title: [Relationship between fibrinogen Bß-148C/T polymorphism and coronary artery lesions in children with Kawasaki disease].
abstract: OBJECTIVE
  To study the possible relationship between coronary artery lesions and fibrinogen Bbeta-148 C/T polymorphism in children with Kawasaki disease.
  
  
  METHODS
  Fast blood samples were taken from 36 children with Kawasaki disease (21 had coronary artery lesions) and 49 age- and gender-matched healthy children (control group). Plasma levels and molecular reactivity of fibrinogen were measured with Assist Plasma Fibrinogen Activity Assay System. Polymerize chain reaction and restriction enzyme digestion were used to detect the genotypes of fibrinogen Bbeta-148C/T gene polymorphism.
  
  
  RESULTS
  The plasma fibrinogen levels in patients with coronary artery lesions were significantly higher than those in patients without coronary artery lesions and in the control group. T allele frequency in patients with Kawasaki disease was significantly higher than that in the control group. The patients with coronary artery lesions had more increased T allele frequency compared with the patients without coronary artery lesions.
  
  
  CONCLUSIONS
  Plasma fibrinogen levels and fibrinogen Bbeta-148C/T polymorphism are associated with coronary artery lesions in children with Kawasaki disease.
authors.affiliation: Department of Pediatrics, Affiliated Hospital of North China Coal Medical College, Tangshan, Hebei, China. gaojiecong1997@yahoo.com.cn
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Wang
authors.forename: Nai-Jun
authors.initials: NJ
authors.lastname: Wu
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Zhang
mesh_terms: D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000209:etiology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: C115499:BBeta fibrinogen; D005340:Fibrinogen