[Expression of Mta-1 and VEGF and their correlation in the endometrial cancer].
OBJECTIVE
To explore the expression of metastasis-associated protein 1(Mta-1) and vascular endothelial growth factor (VEGF) and their correlation in the endometrial cancer.


METHODS
In 62 cases of endometrial cancer and 30 cases of normal endomedium, the expression of Mta-1 and VEGF was examined with immunohistochemistry and their correlation with pathological phenotype of the endometrial cancer was analyzed.


RESULTS
The expression of Mta-1 and VEGF in endometrial cancer was higher than that in normal endomedium (P<0.01). The expression of Mta-1 and VEGF in endometrial cancer was related to clinical stage, pathologic type, lymph node metastasis and depth of myometrial invasion (P<0.05 or P<0.01). Positive correlation was observed between VEGF and Mta-1 expression(r=0.582, P<0.05).


CONCLUSIONS
Expression of Mta-1 expression and VEGF is positively associated with the development and progression of endometrial cancer.
Yang
Yi-min
YM
Department of Obstetrics and Gynecology, the Third Xiangya Hospital of the Zhongnan University, Changsha 410013, China. yaminy@sina.com
Liu
Hua
H
Li
Wen-bin
WB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
C089320:MTA1 protein, human; D012097:Repressor Proteins; D015534:Trans-Activators; D042461:Vascular Endothelial Growth Factor A; D006655:Histone Deacetylases