Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?
BACKGROUND
EUS-guided FNA (EUS-FNA) is a useful modality for sampling various targets, but its applicability to gallbladder (GB) mass lesions is limited.


OBJECTIVE
To determine the usefulness of EUS-FNA for diagnosing GB mass lesions.


METHODS
Single-center, retrospective, case-series study.


METHODS
Tertiary-care referral center.


METHODS
This study involved 15 consecutive patients who underwent EUS-FNA of GB mass lesions. We punctured GB masses in patients with suspected xanthogranulomatous cholecystitis to distinguish them from malignancy, and in patients with unresectable GB carcinoma for pathological confirmation. The final diagnosis was based on surgical histopathological results or follow-up outcome.


METHODS
EUS-FNA.


METHODS
Evaluation of EUS-FNA sampling adequacy rate and diagnostic yield.


RESULTS
Xanthogranulomatous cholecystitis was suspected in 6 of the 15 patients. EUS-FNA revealed foam cells (n = 3), inflammatory cells (n = 1, proven by cholecystectomy), and GB carcinoma (n = 1), and the amount of the aspirate was insufficient in one case (xanthogranulomatous cholecystitis was later proven by extended hepatectomy). The mean follow-up period of the patients with xanthogranulomatous cholecystitis was 1177 days. Adenocarcinoma was confirmed by EUS-FNA in 8 of the 9 patients with suspected unresectable GB carcinoma, and the FNA was inconclusive in one. All 10 patients with GB carcinoma underwent chemotherapy. The overall sampling adequacy was 86.6%. The accuracy of EUS-FNA for detecting malignancy and for the final diagnosis was 93.3% (95% CI, 62.4%-99.9%) and 80% (95% CI, 54%-93.7%), respectively.


CONCLUSIONS
A small patient cohort and a retrospective design with potential selection bias.


CONCLUSIONS
Malignant GB mass lesions can be safely and accurately differentiated by EUS-FNA. Thus, patients with xanthogranulomatous cholecystitis can avoid undue extensive surgery.
Hijioka
Susumu
S
Department of Gastroenterology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan.
Mekky
Mohamed A
MA
Bhatia
Vikram
V
Sawaki
Akira
A
Mizuno
Nobumasa
N
Hara
Kazuo
K
Hosoda
Waki
W
Shimizu
Yasuhiro
Y
Tamada
Kiichi
K
Niwa
Yasumasa
Y
Yamao
Kenji
K
D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002764:Cholecystitis / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D006099:Granuloma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional; D014973:Xanthomatosis / Q000000981:diagnostic imaging / Q000473:pathology