title: Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats.
abstract: OBJECTIVE
  Evaluation of modafinil effects on the inhibitory avoidance task (IA).
  
  
  METHODS
  Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.
  
  
  RESULTS
  In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.
  
  
  CONCLUSIONS
  Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.
authors.affiliation: Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Karin Monteiro
authors.initials: KM
authors.lastname: Moreira
authors.forename: Tatiana Lima
authors.initials: TL
authors.lastname: Ferreira
authors.forename: Debora Cristina
authors.initials: DC
authors.lastname: Hipolide
authors.forename: Raquel Vecchio
authors.initials: RV
authors.lastname: Fornari
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Maria Gabriela Menezes
authors.initials: MG
authors.lastname: Oliveira
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000150:complications*
chemical_list: D001559:Benzhydryl Compounds; D018696:Neuroprotective Agents; D000077408:Modafinil