An IL-1beta-dependent switch in innate mucosal immunity?
The mechanisms that guide the development of mucosal-associated innate lymphoid cells (ILCs) producing IL-17, IL-22, and IFN-gamma are the subject of intense interest. In this issue of Immunity, Hughes et al. (2010) identify a new role for IL-1beta in regulating an IL-22-producing ILC.
Di Santo
James P
JP
Innate Immunity Unit, Institut Pasteur, F-75724 Paris, France. james.di-santo@pasteur.fr