title: Photothermal bundle measurement of phantoms and blood as a proof of concept for oxygenation saturation measurement.
abstract: This study's objective is to validate a method for the measurement of two compound phantoms as a proof of concept for oxygen saturation level measurement via a thermal imaging bundle. The method consists of a thermal imaging system and an algorithm which estimates the compound concentration according to temperature rise. A temperature rise is obtained by illuminating the tissue with a laser with different wavelengths in the NIR range and measured using a thermal camera. A coherent thermal imaging bundle was used for image transmittance for minimal invasive transendoscopic use. The algorithm's estimation ability was evaluated using agar phantoms of varying Methylene Blue and ICG ratios as well as blood samples The Methylene Blue ratio in each phantom was estimated and the calculated average RMS of the error was 9.38%, a satisfying value for this stage, verifying the algorithm's and bundle's suitability for the use in a minimal invasive system.
authors.affiliation: Tel Aviv University, Biomedical Engineering Department, Ramat Aviv, Tel-Aviv 69978, Israel.
authors.forename: Yonat
authors.initials: Y
authors.lastname: Milstein
authors.forename: Michal
authors.initials: M
authors.lastname: Tepper
authors.forename: Moshe Ben
authors.initials: MB
authors.lastname: David
authors.forename: James A
authors.initials: JA
authors.lastname: Harrington
authors.forename: Israel
authors.initials: I
authors.lastname: Gannot
mesh_terms: D000465:Algorithms; D005336:Fiber Optic Technology / Q000295:instrumentation; D006801:Humans; D007208:Indocyanine Green; D008751:Methylene Blue; D010100:Oxygen / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D019047:Phantoms, Imaging; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013696:Temperature; D013817:Thermography / Q000295:instrumentation / Q000379:methods*
chemical_list: D007208:Indocyanine Green; D010100:Oxygen; D008751:Methylene Blue