title: Creation of large elastase-induced aneurysms: presurgical arterial remodeling using arteriovenous fistulas.
abstract: OBJECTIVE
  The size of elastase-induced aneurysms created in the usual way is relatively small. Our aim was to determine whether creation of a carotid-jugular AVF to induce remodeling of the RCCA results in larger elastase-induced aneurysms in rabbits.
  
  
  METHODS
  RCCA right-jugular AVFs were created in 6 New Zealand white rabbits (group 1), followed by elastase-induced aneurysm creation 4 weeks later. Follow-up DSA was performed to assess AVF patency and aneurysm sizes. Six other elastase-induced aneurysms created in the usual way were used as controls (group 2). The diameters of the RCCA and LCCA in group 1 and aneurysm sizes in both groups were measured from DSA images and compared by using the Student t test.
  
  
  RESULTS
  The patency of AVFs in group 1 was confirmed in all 6 (100%) cases. The mean RCCA diameter in group 1 was larger than that in the contralateral LCCA (3.6 ± 0.7 mm versus 2.0 ± 0.1 mm, range, 1.8-2.2 mm, P < .01). The mean aneurysm neck diameter, width, and height for group 1 was larger than those of group 2 (4.6 ± 0.9 mm versus 3.5 ± 0.7 mm, P < .05; 4.7 ± 1.1 mm versus 3.4 ± 0.5 mm, P < .05; 13.8 ± 3.2 mm versus 8.1 ± 1.3 mm, P < .05, respectively). Aneurysm volume for group 1 was significantly larger than that of group 2 (273 ± 172 mm³ versus 77 ± 32 mm³, P < .05).
  
  
  CONCLUSIONS
  Carotid-jugular AVFs result in RCCA remodeling that yields relatively larger elastase-induced aneurysms.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: D
authors.initials: D
authors.lastname: Dai
authors.forename: R
authors.initials: R
authors.lastname: Kadirvel
authors.forename: D A
authors.initials: DA
authors.lastname: Lewis
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D001164:Arteriovenous Fistula / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D007601:Jugular Veins / Q000000981:diagnostic imaging; D010196:Pancreatic Elastase / Q000633:toxicity*; D057234:Preoperative Period; D011817:Rabbits
chemical_list: D010196:Pancreatic Elastase