title: Anti-ageing and rejuvenating effects of quercetin.
abstract: Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis. The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins. Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence. Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology longer in human primary fibroblasts. Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed. Finally, we show that these compounds promote physiological alterations when applied to cells (i.e. whitening effect). In summary, these data demonstrate the existence of naturally occurring anti-ageing products that can be effectively used through topical application.
authors.affiliation: Institute of Biological Research and Biotechnology, Athens, Greece. nikichon@eie.gr
authors.forename: Niki
authors.initials: N
authors.lastname: Chondrogianni
authors.forename: Suzanne
authors.initials: S
authors.lastname: Kapeta
authors.forename: Ioanna
authors.initials: I
authors.lastname: Chinou
authors.forename: Katerina
authors.initials: K
authors.lastname: Vassilatou
authors.forename: Issidora
authors.initials: I
authors.lastname: Papassideri
authors.forename: Efstathios S
authors.initials: ES
authors.lastname: Gonos
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D019610:Cytoprotection / Q000187:drug effects / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008544:Melanocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000378:metabolism; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D012060:Rejuvenation; D012880:Skin Pigmentation / Q000187:drug effects / Q000502:physiology
chemical_list: D000975:Antioxidants; D011794:Quercetin; D046988:Proteasome Endopeptidase Complex