title: Optimization and scale-up of propionic acid production by propionic acid-tolerant Propionibacterium acidipropionici with glycerol as the carbon source.
abstract: Propionic acid production by Propionibacterium acidipropionici with glycerol as sole carbon source was studied in 7-L batch and 10m(3) bioreactor cultures. In batch cultures, propionic acid production increased and specific cell growth rate decreased with increasing glycerol concentrations. Maximum propionic acid production and productivity reached 44.62+/-1.12g/L and 0.20+/-0.0075gL(-1)h(-1)at 220h, respectively, when glycerol was fed at a constant rate of 0.01L/h from 72 to 120h with an initial glycerol concentration of 30g/L. In the 10m(3) bioreactor, maximum propionic acid production reached 47.28+/-0.12g/L at 240h. This glycerol feeding approach may be useful for propionic acid production on an industrial scale.
authors.affiliation: Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jianghua
authors.initials: J
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Tan
authors.forename: Long
authors.initials: L
authors.lastname: Liu
authors.forename: Lili
authors.initials: L
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.forename: Pengsoon
authors.initials: P
authors.lastname: Lee
authors.forename: Guocheng
authors.initials: G
authors.lastname: Du
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000192:Actinomycetales / Q000187:drug effects / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism*; D010865:Pilot Projects; D011422:Propionates / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D011422:Propionates; D002244:Carbon; C029658:propionic acid; D005990:Glycerol