Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
O'Neill
Paul M
PM
Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD UK. pmoneill@liverpool.ac.uk
Amewu
Richard K
RK
Nixon
Gemma L
GL
Bousejra ElGarah
Fatima
F
Mungthin
Mathirut
M
Chadwick
James
J
Shone
Alison E
AE
Vivas
Livia
L
Lander
Hollie
H
Barton
Victoria
V
Muangnoicharoen
Sant
S
Bray
Patrick G
PG
Davies
Jill
J
Park
B Kevin
BK
Wittlin
Sergio
S
Brun
Reto
R
Preschel
Michael
M
Zhang
Kesheng
K
Ward
Stephen A
SA
D000478:Alkylation; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D010963:Plasmodium falciparum / Q000187:drug effects / Q000302:isolation & purification; D054852:Small Molecule Libraries / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D045568:Tetraoxanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000962:Antimalarials; D037621:Artemisinins; C554719:RKA 182; D054852:Small Molecule Libraries; D013141:Spiro Compounds; D045568:Tetraoxanes