Human papillomavirus infection in a population-based sample of women in Algiers, Algeria.
No data exist on the population prevalence of, nor risk factors for, human papillomavirus (HPV) infection in the predominantly Muslim countries of Northern Africa. Cervical specimens were obtained from 759 married women aged 15-65 years from the general population of Algiers, Algeria. Liquid-based cytology and HPV DNA detection, using a GP5+/6+-based polymerase chain reaction assay that detects 44 HPV types, were performed according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV prevalence in the general population was 6.3% (4.0% of high-risk types), with no significant variation by age. The prevalence of cervical abnormalities was 3.6%. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's extramarital sexual relationships. HPV16/18 accounted for only 15% of HPV-positive women in the general population, compared with 77% of invasive cervical cancer diagnosed in the same city. In conclusion, we report that HPV infection among married women in Algeria is much lower than in sub-Saharan Africa and also lower than in the majority of high-resource countries.
Hammouda
Doudja
D
Institut National de Santé Publique, Algiers, Algeria. dhammouda@voila.fr
Clifford
Gary M
GM
Pallardy
Sophie
S
Ayyach
Ghassan
G
Chékiri
Asma
A
Boudrich
Arab
A
Snijders
Peter J F
PJ
van Kemenade
Folkert J
FJ
Meijer
Chris J L M
CJ
Bouhadef
Anissa
A
Zitouni
Zahia
Z
Habib
Djamila
D
Ikezaren
Nadia
N
Franceschi
Silvia
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000462:Algeria / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000821:virology
D004279:DNA, Viral