Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease.
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is reported to be an effective and safe treatment for superficial non-melanoma skin cancers. We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). Three patients diagnosed with BD by skin biopsy were recruited in this study. They received IPL treatment after 3 h of occlusive dressing with application of ALA. This protocol was repeated every 2 weeks for a total of five sessions. The treated areas did not show any signs of BD for more than 1 year; therefore, it appeared that the affected areas showed improvement in all the patients. No patients withdrew from the study because of side-effects. ALA-PDT with IPL as a light source is well tolerated by patients and is beneficial for treating BD.
Hasegawa
Toshio
T
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan. t-hase@juntendo.ac.jp
Suga
Yasushi
Y
Mizuno
Yuki
Y
Haruna
Kunitaka
K
Ogawa
Hideoki
H
Ikeda
Shigaku
S
D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid