title: Assembly and dynamics of myofibrils.
abstract: We review some of the problems in determining how myofibrils may be assembled and just as importantly how this contractile structure may be renewed by sarcomeric proteins moving between the sarcomere and the cytoplasm. We also address in this personal review the recent evidence that indicates that the assembly and dynamics of myofibrils are conserved whether the cells are analyzed in situ or in tissue culture conditions. We suggest that myofibrillogenesis is a fundamentally conserved process, comparable to protein synthesis, mitosis, or cytokinesis, whether examined in situ or in vitro.
authors.affiliation: Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. sangerjo@upstate.edu
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Sanger
authors.forename: Jushuo
authors.initials: J
authors.lastname: Wang
authors.forename: Yingli
authors.initials: Y
authors.lastname: Fan
authors.forename: Jennifer
authors.initials: J
authors.lastname: White
authors.forename: Jean M
authors.initials: JM
authors.lastname: Sanger
mesh_terms: D000818:Animals; D036681:Fluorescence Recovery After Photobleaching; D006801:Humans; D008954:Models, Biological; D024510:Muscle Development; D009210:Myofibrils / Q000378:metabolism*