NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose.
The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)-biotin starting from D-mannose as chiral pool were completely assigned using one- and two-dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC.
Chen
Wen-Xue
WX
Zhang
Ping
P
Chen
Fen-er
FE
D001710:Biotin / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008358:Mannose / Q000737:chemistry*; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
D001710:Biotin; D008358:Mannose