title: [Research progress of cartilage oligomeric matrix protein].
abstract: OBJECTIVE
  To review the research progress of cartilage oligomeric matrix protein (COMP).
  
  
  METHODS
  Domestic and abroad literature about COMP was reviewed and summarized.
  
  
  RESULTS
  COMP was one of the osteoarthritis (OA) biomarkers of being widely studied. Most studies in recent years could draw the conclusion that COMP was associated with OA. COMP was the foremost biomarker among investigated biomarkers. It could been continuously expressed and predicted knee OA progression.
  
  
  CONCLUSIONS
  Precisely what role COMP plays in OA pathogenesis remains unclear, using COMP as a tool to early diagnose OA more studies would be needed.
authors.affiliation: Department of Spine and Joint, Shengjing Hospital, China Medical University, Shenyang Liaoning, 110001, P.R. China. bailh@cmu2h.com
authors.forename: Lunhao
authors.initials: L
authors.lastname: Bai
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Tianpeng
authors.initials: T
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010003:Osteoarthritis / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins