Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45).
Mizuki
Nobuhisa
N
Department of Ophthalmology and Visual Science, Yokohama City University, Yokohama, Kanagawa, Japan. mizunobu@med.yokohama-cu.ac.jp
Meguro
Akira
A
Ota
Masao
M
Ohno
Shigeaki
S
Shiota
Tomoko
T
Kawagoe
Tatsukata
T
Ito
Norihiko
N
Kera
Jiro
J
Okada
Eiichi
E
Yatsu
Keisuke
K
Song
Yeong-Wook
YW
Lee
Eun-Bong
EB
Kitaichi
Nobuyoshi
N
Namba
Kenichi
K
Horie
Yukihiro
Y
Takeno
Mitsuhiro
M
Sugita
Sunao
S
Mochizuki
Manabu
M
Bahram
Seiamak
S
Ishigatsubo
Yoshiaki
Y
Inoko
Hidetoshi
H
D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005123:Eye; D055106:Genome-Wide Association Study; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D016017:Odds Ratio; D012871:Skin Diseases / Q000235:genetics; D014421:Turkey
D016753:Interleukin-10