title: Impact of abdominopelvic CT on Ewing sarcoma management.
abstract: OBJECTIVE
  Abdominopelvic computed tomography (APCT) is often performed in patients with skeletal Ewing sarcoma family of tumors during initial staging and for subsequent clinical indications, such as metastasis surveillance; however, its clinical impact is unknown. The purpose of this study was to evaluate whether these computed tomographic examinations alter oncologic management and therefore patient outcomes.
  
  
  METHODS
  One hundred eight consecutive patients with skeletal Ewing sarcoma family of tumors seen from 1985 to 2008 were retrospectively reviewed to identify imaging workup, pathology, primary site, evidence of metastatic disease, and patient outcomes. Data were analyzed using Wilcoxon's rank sum tests.
  
  
  RESULTS
  Sixty-five of the 108 patients (60%) underwent 342 abdominopelvic computed tomographic examinations during a mean follow-up period of 8.9 years. During this time period, only one of the 65 patients (1.5%) who underwent APCT was discovered to have abdominal metastatic disease. There was no significant difference in the incidence of metastatic disease to the skeleton or chest between the groups without and with APCT (P = .10). There were 26 pelvic and lumbosacral primaries (24%) and 82 limb primaries (76%). Subgroup analysis performed on the 82 patients with limb primaries without (n = 36) and with (n = 46) APCT showed no significant differences in metastatic incidence to the skeleton or chest (P = .14).
  
  
  CONCLUSIONS
  This study indicates that APCT, associated with increased radiation exposure and health expenditure, has a limited role in initial staging and follow-up in patients with skeletal Ewing sarcoma, particularly in patients with limb primaries.
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA. matthew.dobbs@vanderbilt.edu
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Dobbs
authors.forename: Stefanie R
authors.initials: SR
authors.lastname: Lowas
authors.forename: Marta
authors.initials: M
authors.lastname: Hernanz-Schulman
authors.forename: Ginger E
authors.initials: GE
authors.lastname: Holt
authors.forename: Chang
authors.initials: C
authors.lastname: Yu
authors.forename: J Herman
authors.initials: JH
authors.lastname: Kan
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000556:secondary*; D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000556:secondary*; D011860:Radiography, Abdominal / Q000706:statistics & numerical data; D013902:Radiography, Thoracic / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000556:secondary*; D012680:Sensitivity and Specificity; D013022:South Carolina / Q000453:epidemiology; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D055815:Young Adult