Immunodepletive anti-alpha/beta-TCR antibody in transplantation of composite tissue allografts: Cleveland Clinic research experience.
The immunologic characteristics of composite tissue allografts (CTA), which contain skin, lymphoid elements and bone with bone marrow, raise new challenges for transplant immunologists. Owing to the heterogeneity of transplanted tissues in limb or face transplant models, researchers are focusing on the new tolerance-inducing strategies facilitating CTA acceptance. A number of immunosuppressive protocols have been designed to develop tolerance in experimental models; however, only a few protocols have been introduced to clinical transplantation. In this review, based on own experiences, we discuss the major strategies for tolerance induction in limb and face allograft models in experimental studies. This review is focused on tolerance induction strategies by establishment of donor-specific chimerism using different immunomodulatory protocols, including nonselective T-cell depletion with polyclonal antibody antilymphocyte serum and selective inhibition of alphabeta-T-cell receptors on the alloreactive T cells.
Siemionow
Maria
M
Department of Plastic & Reconstructive Surgery, Cleveland Clinic, 9500 Euclid Avenue, A60, Cleveland, OH 44195, USA. siemiom@ccf.org
Klimczak
Aleksandra
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D035843:Biomedical Research; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D062109:Dermatologic Surgical Procedures; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D008212:Lymphocyte Depletion / Q000379:methods; D008221:Lymphoid Tissue / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D023421:Models, Animal; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D012867:Skin / Q000378:metabolism / Q000473:pathology; D016378:Tissue Transplantation; D023001:Transplantation Tolerance
D000911:Antibodies, Monoclonal; D016693:Receptors, Antigen, T-Cell, alpha-beta