title: Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals.
abstract: Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments.
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Minghao
authors.initials: M
authors.lastname: Dong
authors.forename: Jixin
authors.initials: J
authors.lastname: Liu
authors.forename: Jinbo
authors.initials: J
authors.lastname: Sun
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yarong
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhao
authors.forename: Karen M
authors.initials: KM
authors.lastname: von Deneen
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.forename: Mark S
authors.initials: MS
authors.lastname: Gold
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D006556:Heroin Dependence / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors