Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1.
The novel gene HA117 is a multidrug resistance (MDR) gene in all-trans retinoic acid resistance HL-60 cells. The transduction of adenovirus vectors encoding HA117 conferred breast cancer cell line 4T1 MDR not only to MRP1 substrate drugs but also to MRP1 non-substrate drugs and the MDR strength of HA117 was similar to that of multidrug resistance-associated protein-1 (MRP1) for MRP1 substrate, but HA117 had no daunorubicin-excretion function.
Zhao
Lihua
L
Laboratory of Oncology, Department of Surgery, Affiliated Children's Hospital, Chongqing Medical University, No.136, Zhongshan 2nd Road Yuzhong District, Chongqing, 86 400014, China.
Sun
Yanhui
Y
Li
Xiaoqing
X
Jin
Xianqing
X
Xu
Youhua
Y
Guo
Zhenhua
Z
Liang
Rui
R
Ding
Xionghui
X
Chen
Tingfu
T
Wang
Siqi
S
D015153:Blotting, Western; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019450:Genes, MDR / Q000235:genetics*; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014161:Transduction, Genetic
D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1