Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women.
OBJECTIVE
It has been suggested that the serotonergic systems are associated with anger and aggressive behaviors. We investigated the association between several single nucleotide polymorphisms in the serotonergic genes and anger-related personality traits.


METHODS
A total of 228 healthy female Korean women participated in this study. All subjects were assessed with the State-Trait Anger Expression Inventory (STAXI) and were genotyped for 3 polymorphisms: serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), tryptophan hydroxylase 1 (TPH1) A218C, and TPH2 G-703T.


RESULTS
The Anger Expression-Out (AX-Out) subscale scores of the STAXI differed significantly between the genotypes for the TPH2 G-703T polymorphism (F = 4.825, p = 0.009). G/G homozygous subjects scored significantly higher on the AX-Out subscale than those with the G/T genotype. However, no significant differences were observed in the relationships between the STAXI subscale scores of subjects with other polymorphisms.


CONCLUSIONS
This study suggests that the TPH2 G-703T polymorphism might contribute to anger-related traits, especially to the expression of anger.
Yang
Jaewon
J
Department of Psychiatry, Korea University, Seoul, South Korea.
Lee
Moon-Soo
MS
Lee
So-Hee
SH
Lee
Boung-Chul
BC
Kim
Seung-Hyun
SH
Joe
Sook-Haeng
SH
Jung
In-Kwa
IK
Choi
Ihn-Geun
IG
Ham
Byung-Joo
BJ
D000328:Adult; D000786:Anger / Q000502:physiology*; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007723:Korea; D010551:Personality / Q000502:physiology*; D010552:Personality Assessment; D020641:Polymorphism, Single Nucleotide; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins; C497467:TPH1 protein, human; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase