title: Cameroonemide A: a new ceramide from Helichrysum cameroonense.
abstract: From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), beta-sitosterol (4), and beta-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
authors.forename: Kakam Zanetsie
authors.initials: KZ
authors.lastname: Antoine
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Etienne
authors.initials: E
authors.lastname: Dongo
authors.forename: Simeon F
authors.initials: SF
authors.lastname: Kouam
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects*; D002163:Cameroon; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036562:Helichrysum / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000900:Anti-Bacterial Agents; D002518:Ceramides; C551222:cameroonemide A