title: Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT).
abstract: There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.
authors.affiliation: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. m.hoogduijn@erasmusmc.nl
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Hoogduijn
authors.forename: Felix C
authors.initials: FC
authors.lastname: Popp
authors.forename: Anja
authors.initials: A
authors.lastname: Grohnert
authors.forename: Meindert J
authors.initials: MJ
authors.lastname: Crop
authors.forename: Marieke
authors.initials: M
authors.lastname: van Rhijn
authors.forename: Ajda T
authors.initials: AT
authors.lastname: Rowshani
authors.forename: Elke
authors.initials: E
authors.lastname: Eggenhofer
authors.forename: Philipp
authors.initials: P
authors.lastname: Renner
authors.forename: Marlies E
authors.initials: ME
authors.lastname: Reinders
authors.forename: Ton J
authors.initials: TJ
authors.lastname: Rabelink
authors.forename: Luc J W
authors.initials: LJ
authors.lastname: van der Laan
authors.forename: Frank J M F
authors.initials: FJ
authors.lastname: Dor
authors.forename: Jan N M
authors.initials: JN
authors.lastname: Ijzermans
authors.forename: Paul G
authors.initials: PG
authors.lastname: Genever
authors.forename: Claudia
authors.initials: C
authors.lastname: Lange
authors.forename: Antoine
authors.initials: A
authors.lastname: Durrbach
authors.forename: Jaco H
authors.initials: JH
authors.lastname: Houtgraaf
authors.forename: Bruno
authors.initials: B
authors.lastname: Christ
authors.forename: Martina
authors.initials: M
authors.lastname: Seifert
authors.forename: Murat
authors.initials: M
authors.lastname: Shagidulin
authors.forename: Vincent
authors.initials: V
authors.lastname: Donckier
authors.forename: Robert
authors.initials: R
authors.lastname: Deans
authors.forename: Olle
authors.initials: O
authors.lastname: Ringden
authors.forename: Norberto
authors.initials: N
authors.lastname: Perico
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Remuzzi
authors.forename: Amelia
authors.initials: A
authors.lastname: Bartholomew
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Schlitt
authors.forename: Willem
authors.initials: W
authors.lastname: Weimar
authors.forename: Carla C
authors.initials: CC
authors.lastname: Baan
authors.forename: Marc H
authors.initials: MH
authors.lastname: Dahlke
mesh_terms: D018929:Cell Culture Techniques; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016130:Immunophenotyping; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology; D016031:Liver Transplantation / Q000276:immunology / Q000502:physiology; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology; D016377:Organ Transplantation / Q000379:methods* / Q000502:physiology; D012449:Safety; D013601:T-Lymphocytes / Q000276:immunology