Mannose-binding lectin genotypes and susceptibility to epstein-barr virus infection in infancy.
In a cohort study of children < 4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient children, indicating that MBL may be involved in primary EBV infection in infancy.
Friborg
Jeppe T
JT
Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen S, Denmark.
Jarrett
Ruth F
RF
Koch
Anders
A
Garred
Peter
P
Freeland
June M L
JM
Andersen
Andreas
A
Melbye
Mads
M
D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D020031:Epstein-Barr Virus Infections / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005838:Genotype; D006116:Greenland; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D008297:Male; D037601:Mannose-Binding Lectin / Q000172:deficiency* / Q000235:genetics
D000914:Antibodies, Viral; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin