title: Crossed over repair of the femoral sensory and motor branches influences N-CAM.
abstract: N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of sensory and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair.
authors.affiliation: Department of Orthopaedic Surgery, Murayama Medical Center, National Hospital Organization, Tokyo, Japan.
authors.forename: Harukazu
authors.initials: H
authors.lastname: Saito
authors.forename: Martin
authors.initials: M
authors.lastname: Kanje
authors.forename: Lars B
authors.initials: LB
authors.lastname: Dahlin
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D005267:Femoral Nerve / Q000293:injuries / Q000502:physiology* / Q000601:surgery; D020439:Growth Cones / Q000502:physiology / Q000648:ultrastructure; D009046:Motor Neurons / Q000502:physiology* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000502:physiology*; D019006:Neural Cell Adhesion Molecules / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000502:physiology; D012583:Schwann Cells / Q000502:physiology / Q000648:ultrastructure; D011984:Sensory Receptor Cells / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D019006:Neural Cell Adhesion Molecules