Aptatag-based multiplexed assay for protein detection by surface-enhanced Raman spectroscopy.
Silver-nanoparticle dimers held together by a Raman reporter, capped with DNA aptamers and stabilized by polyethylene glycol chains, can be used to develop a multiplexed heterogeneous bioassay for protein detection with high sensitivity and selectivity.
Fabris
Laura
L
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. lfabris@rci.rutgers.edu
Schierhorn
Martin
M
Moskovits
Martin
M
Bazan
Guillermo C
GC
D001483:Base Sequence; D017931:DNA Primers; D006801:Humans; D057230:Limit of Detection; D011506:Proteins / Q000032:analysis*; D015203:Reproducibility of Results; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
D017931:DNA Primers; D011506:Proteins