title: Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy.
abstract: OBJECTIVE
  To report 3 patients who developed anti-N-methyl-d-aspartate receptor encephalitis during pregnancy.
  
  
  METHODS
  Case reports.
  
  
  METHODS
  University hospitals. Patients Three young women developed at 14, 8, and 17 weeks of gestation acute change of behavior, prominent psychiatric symptoms, progressive decrease of consciousness, seizures, dyskinesias, and autonomic dysfunction.
  
  
  METHODS
  Clinical, radiological, and immunological findings.
  
  
  RESULTS
  The 3 patients had cerebrospinal fluid pleocytosis, normal magnetic resonance imaging, and electroencephalogram showing slow activity. All had higher antibody titers in cerebrospinal fluid than in serum and 2 had ovarian teratomas that were removed. The pregnancy was terminated in 1 patient with recurrent bilateral teratomas. All patients had substantial neurological recoveries, and the 2 newborns were normal. Results of extensive antibody testing in 1 of the babies were negative.
  
  
  CONCLUSIONS
  The current study shows that anti-NMDAR encephalitis during pregnancy can have a good outcome for the mother and newborn.
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA.
authors.forename: Monisha A
authors.initials: MA
authors.lastname: Kumar
authors.forename: Ankit
authors.initials: A
authors.lastname: Jain
authors.forename: Valerie E
authors.initials: VE
authors.lastname: Dechant
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Saito
authors.forename: Timothy
authors.initials: T
authors.lastname: Rafael
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Aizawa
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Dysart
authors.forename: Takayuki
authors.initials: T
authors.lastname: Katayama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ito
authors.forename: Nobuo
authors.initials: N
authors.lastname: Araki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Abe
authors.forename: Rita
authors.initials: R
authors.lastname: Balice-Gordon
authors.forename: Josep
authors.initials: J
authors.lastname: Dalmau
mesh_terms: D000906:Antibodies / Q000097:blood*; D004660:Encephalitis / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D055815:Young Adult
chemical_list: D000906:Antibodies; D016194:Receptors, N-Methyl-D-Aspartate