title: Bioactive isoflavones from Dalbergia vacciniifolia (Fabaceae).
abstract: Three new 5-dehydroxy isoflavone compounds, 6,2'-dimethoxy-7,4'-dihydroxyisoflavone (1), 6,2',4'-trimethoxy-7-hydroxyisoflavone (2), and 6,2',4',5'-tetramethoxy-7-O-[beta-D-apiofuranosyl-(1 --> 6)-beta-D-glucopyranoside] isoflavone (3), along with a known isoflavone, 6,2',4',5'-tetramethoxy-7-hydroxyisoflavone (4), were isolated from the ethanolic extract of Dalbergia vacciniifolia Vatke. Their structures were established by spectroscopic techniques including one- and two-dimension NMR. Compound 1 showed mild cytotoxic activity against brine shrimp larvae with a LC50 value of 266 microg/mL.
authors.affiliation: Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania. einnocent@muhas.ac.tz
authors.forename: Ester
authors.initials: E
authors.lastname: Innocent
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Magadula
authors.forename: Charles
authors.initials: C
authors.lastname: Kihampa
authors.forename: Matthias
authors.initials: M
authors.lastname: Heydenreich
mesh_terms: D035782:Dalbergia / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry
chemical_list: D007529:Isoflavones