Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy.
OBJECTIVE
Talin 2 plays an important role in cell adhesion and recycling of synaptic vesicles. To explore the possible role of talin 2 in epilepsy, we designed current study to quantitatively evaluate the changes in talin 2 levels in different epilepsy patients.


METHODS
We measured talin 2 levels in CSF and the serum of postencephalitic epilepsy (PEE) patients (subdivided into drug-refractory PEE-RPEE, and drug-effective PEE-EPEE groups) and acute encephalitis patients (subdivided into acute encephalitis with secondary seizures-AESS, and acute encephalitis without seizures-AE) by enzyme-linked immunosorbent assay.


RESULTS
We found that, in RPEE patients, interictal CSF-talin 2 concentrations significantly increased, whereas serum-talin 2 significantly decreased when compared with the AE, AESS, and EPEE groups.


CONCLUSIONS
This result suggested that the differential concentration of CSF and serum-talin 2 in the RPEE group is an intractability-related phenomenon that might be involved in the development of RPEE.
Xiao
Zheng
Z
Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
Shen
Lan
L
Chen
Dan
D
Wang
Liang
L
Xi
Zhiqin
Z
Xiao
Fei
F
Wang
Xuefeng
X
D000293:Adolescent; D000328:Adult; D002648:Child; D004351:Drug Resistance; D004660:Encephalitis / Q000134:cerebrospinal fluid; D004827:Epilepsy / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000134:cerebrospinal fluid; D016608:Talin / Q000097:blood / Q000134:cerebrospinal fluid*; D055815:Young Adult
C436513:TLN2 protein, human; D016608:Talin