title: Activity of extracts and procesterol from Calotropis gigantea against Entamoeba histolytica.
abstract: Extracts from the root bark of Calotropis gigantea were subjected to bioactivity-guided fractionation using growth inhibitory effects against Entamoeba histolytica. The n-hexane soluble portion of the chloroform extract showed in vitro antiamoebic activity against the HK-9 strain of Entamoeba histolytica. Chromatographic separation of the chloroform extract afforded the known compound, procesterol, which showed activity against E. histolytica.
authors.affiliation: Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S-G Highway, Thaltej, Ahmedabad-380054, India. shailench@yahoo.co.in
authors.forename: Shailendra
authors.initials: S
authors.lastname: Singh
authors.forename: Neelam
authors.initials: N
authors.lastname: Bharti
authors.forename: Manoj
authors.initials: M
authors.lastname: Chugh
authors.forename: Fehmida
authors.initials: F
authors.lastname: Naqvi
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D031107:Calotropis / Q000737:chemistry*; D004748:Entamoeba histolytica / Q000187:drug effects*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D013256:Steroids; C551423:procesterol