title: Clinicopathological features of adenosquamous pancreatic cancer.
abstract: OBJECTIVE
  Adenosquamous pancreatic cancer represents 0.9-4.4% of exocrine pancreatic neoplasms and is generally thought to be associated with a worse prognosis than the more common ductal adenocarcinoma. The aim of the current study is to describe the outcome of patients with adenosquamous pancreatic cancer in our institution who were managed in a multidisciplinary environment.
  
  
  METHODS
  In a retrospective analysis between February 1990 and February 2010, we identified from our database of 890 pancreatic lesions resected for malignancy six cases (0.67%) of adenosquamous cancer. We assessed the demographics, clinical and radiological features, surgical approach, histological details and follow-up data.
  
  
  RESULTS
  All patients underwent pylorus-preserving pancreatoduodenectomy. Two patients, one male and one female, died in the preoperative period due to sepsis and myocardial infarction, respectively. The remaining four patients received adjuvant chemotherapy. One male patient died with local recurrence after 13 months; however, one female and two male patients are still alive with Karnofsky status of 80-90% at 15, 14 and 39 months after the operation, respectively.
  
  
  CONCLUSIONS
  The prognosis of adenosquamous pancreatic cancer remains very poor, apparently worse than ductal pancreatic cancer. Nevertheless, our report and the review of literature seem to show that "curative" surgical resection associated with adjuvant treatment may offer the best results with a similar survival rate than ductal pancreatic cancer.
authors.affiliation: Surgical and Gastroenterological Department, University of Verona, Policlinico Borgo Roma, Piazzale LA Scuro #10, 37134 Verona, Italy. paoloregi@tiscali.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Regi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Butturini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Malleo
authors.forename: Federica
authors.initials: F
authors.lastname: Pedica
authors.forename: Mirko
authors.initials: M
authors.lastname: D'Onofrio
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassi
mesh_terms: D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011379:Prognosis; D012189:Retrospective Studies