title: Comparison of hemoglobin A1c and fasting glucose criteria to diagnose diabetes among people with metabolic syndrome and fasting glucose above 100 mg/dL (5.5 mmol/L).
abstract: The aim of this study was to compare hemoglobin A(1c) (HbA(1c)) and fasting glucose for the diagnosis of diabetes among people with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L). Consecutive individuals (N=142) with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L) but without a self-reported history of diabetes who visited the outpatient lipid and obesity clinic of the University Hospital of Ioannina, Greece from January through September 2009 were included. HbA(1c)> or =6.5% and fasting glucose > or =126 mg/dL (7 mmol/L) were used separately to define diabetes. Overall, 29.5% of patients had both HbA(1c)> or =6.5% and fasting glucose > or =126 mg/dL (7 mmol/L), 25.3% had HbA(1c)> or =6.5% but fasting glucose <126 mg/dL (7 mmol/L), and 9.1% had HbA(1c) <6.5% but fasting glucose > or =126 mg/dL (7 mmol/L). A greater proportion of patients reached a diagnosis of diabetes based on the HbA(1c) criterion (n=78, 54.9%) compared with the fasting glucose criterion (n=55, 38.7%, P=.000). A large proportion of patients (44.8%) with impaired fasting glucose (fasting glucose 100-125 mg/dL; 5.6-6.9 mmol/L) would be classified as diabetics using the HbA(1c) criterion. Implication of the HbA(1c) criterion may increase the rate of diabetes diagnosis among people with metabolic syndrome and fasting glucose >100 mg/dL (5.5 mmol/L).
authors.affiliation: Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece. vaglimp@yahoo.com
authors.forename: Evangelos N
authors.initials: EN
authors.lastname: Liberopoulos
authors.forename: Matilda
authors.initials: M
authors.lastname: Florentin
authors.forename: Anastazia
authors.initials: A
authors.lastname: Kei
authors.forename: Elisavet
authors.initials: E
authors.lastname: Mountzouri
authors.forename: Aris
authors.initials: A
authors.lastname: Agouridis
authors.forename: Moses S
authors.initials: MS
authors.lastname: Elisaf
mesh_terms: D000704:Analysis of Variance; D001681:Biological Assay; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D005215:Fasting / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006305:Health Status Indicators; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin