title: Seventy-four-year-old woman with myelodysplastic syndrome and splenomegaly.
abstract: We present a 74-year-old woman with a recent diagnosis of myelodysplastic syndrome who presented with left upper quadrant abdominal pain and fatigue with significant splenomegaly, anemia, and thrombocytopenia. She underwent splenectomy and bone marrow biopsy. Pathology of both spleen and bone marrow revealed an unusual diagnosis. A review of the differential diagnosis, laboratory tests, nature of the underlying disease, and treatment are provided.
authors.affiliation: Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555-1083, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Motosue
authors.forename: Jack
authors.initials: J
authors.lastname: Alperin
authors.forename: Mohamed T
authors.initials: MT
authors.lastname: Elghetany
authors.forename: Rana
authors.initials: R
authors.lastname: Bonds
mesh_terms: D015746:Abdominal Pain; D000368:Aged; D001853:Bone Marrow / Q000201:enzymology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008407:Mast Cells / Q000473:pathology; D034721:Mastocytosis, Systemic / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly; D013921:Thrombocytopenia; D053802:Tryptases / Q000378:metabolism
chemical_list: D053802:Tryptases