title: Facile preparation of oxazole-4-carboxylates and 4-ketones from aldehydes using 3-oxazoline-4-carboxylates as intermediates.
abstract: A novel 2-step synthesis of oxazole-4-carboxylates from aldehydes was developed, which is characterized by the utilization of 3-oxazoline-4-carboxylates as synthetic intermediates. The facile preparation of 4-keto-oxazole derivatives from 3-oxazoline-4-carboxylates based on their interesting reactivity toward Grignard reagents is also described.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Murai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takahara
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Matsushita
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Komatsu
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujioka
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D002264:Carboxylic Acids; D007202:Indicators and Reagents; D007659:Ketones; D010080:Oxazoles