Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT).
There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.
Hoogduijn
Martin J
MJ
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. m.hoogduijn@erasmusmc.nl
Popp
Felix C
FC
Grohnert
Anja
A
Crop
Meindert J
MJ
van Rhijn
Marieke
M
Rowshani
Ajda T
AT
Eggenhofer
Elke
E
Renner
Philipp
P
Reinders
Marlies E
ME
Rabelink
Ton J
TJ
van der Laan
Luc J W
LJ
Dor
Frank J M F
FJ
Ijzermans
Jan N M
JN
Genever
Paul G
PG
Lange
Claudia
C
Durrbach
Antoine
A
Houtgraaf
Jaco H
JH
Christ
Bruno
B
Seifert
Martina
M
Shagidulin
Murat
M
Donckier
Vincent
V
Deans
Robert
R
Ringden
Olle
O
Perico
Norberto
N
Remuzzi
Giuseppe
G
Bartholomew
Amelia
A
Schlitt
Hans J
HJ
Weimar
Willem
W
Baan
Carla C
CC
Dahlke
Marc H
MH
D018929:Cell Culture Techniques; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016130:Immunophenotyping; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology; D016031:Liver Transplantation / Q000276:immunology / Q000502:physiology; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology; D016377:Organ Transplantation / Q000379:methods* / Q000502:physiology; D012449:Safety; D013601:T-Lymphocytes / Q000276:immunology