title: Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris.
abstract: OBJECTIVE
  We examined whether distinct monocyte subsets relate in specific ways to coronary fibrous cap thickness (FCT) in patients with unstable angina pectoris (UAP).
  
  
  METHODS
  Forty patients with UAP who underwent percutaneous coronary intervention were enrolled in this study. The changes in the non-culprit FCT were assessed by optical coherence tomography (OCT) at baseline and after 9 months. The distinct monocyte subsets (CD14+CD16-CCR2+ and CD14+CD16+CX3CR1+) were measured by flow cytometry.
  
  
  RESULTS
  The percent change in FCT showed significantly negative correlation with the percent changes in CD14+CD16+CX3CR1+ monocytes, but not CD14+CD16-CCR2+ monocytes. In addition, the percent change in CD14+CD16+CX3CR1+ monocytes was significantly decreased in the group of patients who received statin treatment compared with the group of patients who did not. Of interest, there was a close relationship between CD14+CD16+CX3CR1+ monocytes and levels of C-reactive protein, but not lipid profiles, including low-density lipoprotein cholesterol and low-/high-density lipoprotein cholesterol ratio.
  
  
  CONCLUSIONS
  CD14+CD16+CX3CR1+ monocytes may have a role in coronary plaque vulnerability.
authors.affiliation: Department of Cardiovascular Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama, Japan. t-imani@wakayama-med.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Imanishi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ikejima
authors.forename: Hiroto
authors.initials: H
authors.lastname: Tsujioka
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroi
authors.forename: Kohei
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Komukai
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanimoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ino
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takeshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Akasaka
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000473:pathology; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D001772:Blood Cell Count; D000073883:CX3C Chemokine Receptor 1; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology* / Q000378:metabolism; D009206:Myocardium / Q000473:pathology; D054390:Receptors, CCR2 / Q000096:biosynthesis; D019707:Receptors, Chemokine / Q000096:biosynthesis; D017452:Receptors, IgG / Q000096:biosynthesis
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D008055:Lipids; D018950:Lipopolysaccharide Receptors; D054390:Receptors, CCR2; D019707:Receptors, Chemokine; D017452:Receptors, IgG