Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis.
Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.
Huh
Sungran
S
Biospectrum Life Science Institute, Gunpo, Gyunggi Do 435-833, Republic of Korea.
Kim
Young-Soo
YS
Jung
Eunsun
E
Lim
Jihee
J
Jung
Kwang Sun
KS
Kim
Myeong-Ok
MO
Lee
Jongsung
J
Park
Deokhoon
D
D000818:Animals; D045744:Cell Line, Tumor; D002849:Chromatography, Gas; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice
D004952:Esters; D005227:Fatty Acids; D008543:Melanins; D000242:Cyclic AMP