title: [Survival of patients with malignant astrocytomas according to the expression of Ki67 antigen in a pediatric hospital].
abstract: BACKGROUND
  Pediatric patients with malignant gliomas and same histological diagnosis respond distinctly to treatment. It is thus necessary to determine other factors that may influence the response to treatment and survival. Over expression of the Ki67 protein has been associated with poor treatment response. The aim of this study was to determine if the expression of this antigen influences survival of patients treated for malignant gliomas in the CMN SXXI Pediatrics Hospital.
  
  
  METHODS
  We included patients with anaplasic astrocitoma or glioblastoma multiforme seen at our hospital between 1995 and 2005. We determined the expression of Ki67 by immunohistochemistry and correlated the findings with tumor histology and patient survival.
  
  
  RESULTS
  Of the 21 patients studied, 12 overexpressed antigen Ki67. There was no significant association between over expression of Ki67 and survival, although we observed a clinical association. Over expression of Ki67 correlated with more aggressive histology. Being under the age of 11 was a poor prognostic factor. Overall survival was 49% at 120 months.
  
  
  CONCLUSIONS
  Being young (under 11 years) is a marker of poor prognosis among pediatric patients with anaplasic astrocytoma or glioblastoma multiforme. Overexpression expression of antigen Ki67 is associated with histology and may be associated with poor survival among patients treated in our hospital.
authors.affiliation: Departamento de Oncología Pediátrica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México D.F., México. elopezaguilar@hotmail.com
authors.forename: Enrique
authors.initials: E
authors.lastname: López-Aguilar
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Sepúlveda Vildósola
authors.forename: Ana Paulina
authors.initials: AP
authors.lastname: Rioscovián-Soto
authors.forename: Graciela
authors.initials: G
authors.lastname: Gascón-Lastiri
authors.forename: Federico
authors.initials: F
authors.lastname: Rojas-Puentes
authors.forename: Georgina
authors.initials: G
authors.lastname: Siordia-Reyes
authors.forename: Jaime
authors.initials: J
authors.lastname: Diegopérez-Ramírez
authors.forename: Hermilo
authors.initials: H
authors.lastname: De la Cruz-Yáñez
authors.forename: Carolina
authors.initials: C
authors.lastname: Barrientos-Salcedo
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000378:metabolism* / Q000401:mortality*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D011379:Prognosis; D015996:Survival Rate
chemical_list: D019394:Ki-67 Antigen