title: Non-steroidal anti-inflammatory drug induced injury to the small intestine.
abstract: Non-steroidal anti-inflammatory drug (NSAIDs) induced enteropathy represents an important complication of one of the most commonly used drugs worldwide. Due to previous diagnostics difficulties the real prevalence of this disease was underestimated for a long time. The pathogenesis of NSAID-enteropathy is more multifactorial and complex than formerly assumed but has still not been fully uncovered. A combination of the local and systemic effect plays an important role in pathogenesis. Thanks to novel enteroscopy methods (wireless capsule endoscopy, double balloon enteroscopy), small bowel lesions are described in a substantial section of NSAID users although most are clinically asymptomatic. The other non-invasive tests (small bowel permeability, faecal calprotectin, scintigraphy using faecal excretion of 111-indium-labelled leukocytes etc.) proposed for diagnostics are not generally used in clinical practice, mainly because of their non-specificity. Despite intensive research into possible treatment, the main measure for patients with NSAID-enteropathy is still withdrawal of NSAIDs. Double balloon enteroscopy plays an important role in the treatment of complications (bleeding, strictures).
authors.affiliation: Charles University in Praha, Faculty of Medicine and 2nd Department of Internal Medicine, Division of Gastroenterology, University Hospital Hradec Králové, Czech Republic. tacheci@gmail.com
authors.forename: Ilja
authors.initials: I
authors.lastname: Tachecí
authors.forename: Marcela
authors.initials: M
authors.lastname: Kopácová
authors.forename: Stanislav
authors.initials: S
authors.lastname: Rejchrt
authors.forename: Jan
authors.initials: J
authors.lastname: Bures
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D003937:Diagnosis, Differential; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin