Statisticians and pharmacokineticists: what they can still learn from each other.
Examples are given of how the practice of statistics could be improved if statisticians showed a greater awareness of pharmacokinetic and pharmacodynamic modeling. Some examples are also given where a wider appreciation of statistical theory would improve current approaches to pharmacometrics. Areas in which the two disciplines are in agreement but have failed to have as much influence on others in drug development as they ought are also considered. It is concluded that there would be much benefit in increasing collaboration between these disciplines.
Senn
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Department of Statistics, University of Glasgow, Glasgow, UK. stephen@stats.gla.ac.uk
D002986:Clinical Trials as Topic / Q000379:methods; D003299:Cooperative Behavior; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D013223:Statistics as Topic / Q000379:methods*