Effect of Ocimum sanctum on homocysteine levels and lipid profile in healthy rabbits.
BACKGROUND
Ocimum sanctum has been reported to have a variety of medicinal properties.


OBJECTIVE
The present study was planned to evaluate the effect of O. sanctum on plasma homocysteine levels and lipid profile in healthy rabbits.


METHODS
Forty rabbits were divided into two groups (20 each). Group I rabbits received normal diet and group II rabbits received fresh leaves of O. sanctum (2 g/day) for 8 weeks along with normal diet. Fasting plasma samples were estimated for homocysteine and lipid profile. The results were analysed statistically.


RESULTS
The levels of homocysteine, total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol were found to be decreased and high density lipoprotein cholesterol levels increased significantly on supplementation with O. sanctum (p < 0.001).


CONCLUSIONS
Thus, O. sanctum can prove to be a significant cardioprotective substance and an important adjuvant in the treatment of hyperhomocysteinemia and dyslipidemia.
Dahiya
Kiran
K
Department of Biochemistry, Pt. B.D.S. PGIMS, Rohtak, Haryana. kirandahiya_2002@yahoo.com
Sethi
Jyoti
J
Dhankhar
Rakesh
R
Singh
Veena
V
Singh
Sangeeta B
SB
Yadav
Mridul
M
Sood
Sushama
S
Sachdeva
Ashuma
A
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002316:Cardiotonic Agents / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000178:diet therapy / Q000517:prevention & control; D050171:Dyslipidemias / Q000178:diet therapy / Q000517:prevention & control; D005260:Female; D006710:Homocysteine / Q000097:blood; D020138:Hyperhomocysteinemia / Q000178:diet therapy / Q000517:prevention & control; D050356:Lipid Metabolism / Q000502:physiology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D031339:Ocimum; D018515:Plant Leaves; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002316:Cardiotonic Agents; D008074:Lipoproteins; D014280:Triglycerides; D006710:Homocysteine