title: Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates.
abstract: Rh isoimmunization manifesting as isolated early onset neonatal anemia has not been reported. We describe the presentation of 3 infants who manifested with isolated early severe anemia. All the infants presented early (3 to 7 d of age) with severe pallor. None had clinically significant jaundice. Evidence for hemolysis was present in all and their direct antiglobulin test was positive. To reduce the hemolysis, immunoglobulin was administered after which their hemoglobin improved. This report highlights the possibility of early onset anemia without significant jaundice as the sole manifestation of Rh isoimmunization and the possible beneficial role of immunoglobulin in them.
authors.affiliation: Newborn Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Louis
authors.forename: Sapna
authors.initials: S
authors.lastname: Oberoi
authors.forename: Venkataseshan
authors.initials: V
authors.lastname: Sundaram
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
mesh_terms: D000743:Anemia, Hemolytic / Q000503:physiopathology* / Q000628:therapy; D000751:Anemia, Neonatal / Q000503:physiopathology* / Q000628:therapy; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D012203:Rh Isoimmunization / Q000503:physiopathology* / Q000628:therapy; D018029:Rho(D) Immune Globulin / Q000627:therapeutic use
chemical_list: D016756:Immunoglobulins, Intravenous; D018029:Rho(D) Immune Globulin