Two new 4-arylcoumarins from the seeds of Calophyllum polyanthum.
Two new 4-arylcoumarins, 7,4'-dihydroxy-6,8-dimethoxy-4-phenylcoumarin (1) and 7-hydroxy-6,8,4'-trimethoxy-4-phenylcoumarin (2), together with four known compounds were isolated from the seeds of Calophyllum polyanthum. The structures of the new compounds were determined by extensive spectroscopic analyses, and the structure of compound 2 was confirmed by X-ray crystallography analysis. Both new compounds exhibited significant cell protective activities against H(2)O(2)-induced human umbilical vein endothelial cell damage.
Zhong
Hao
H
Key Laboratory of Natural Medicinal Chemistry and Resources Evaluation of Hubei Province, College of Pharmacy, Tongji Medical Center of Huazhong University of Science and Technology, Wuhan, China.
Ruan
Jin-Lan
JL
Yao
Qing-Qiang
QQ
D029759:Calophyllum / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
C551208:7,4'-dihydroxy-6,8-dimethoxy-4-phenylcoumarin; C551209:7-hydroxy-6,8,4'-trimethoxy-4-phenylcoumarin; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D006861:Hydrogen Peroxide