title: Epilepsy surgery in tuberous sclerosis complex: emphasis on surgical candidate and neuropsychology.
abstract: OBJECTIVE
  To discuss neuropsychological outcome and candidate of epilepsy surgery for tuberous sclerosis complex (TSC).
  
  
  METHODS
  To retrospectively analyze clinical data of 25 patients with TSC and epilepsy who underwent epilepsy surgery between 2001 and 2007. Seizure reduction was analyzed at 1-year (1FU), 2-year (2FU), and 5-year (5FU) follow-up visits after surgery, and outcomes of intelligence quotient (IQ) and quality of life (QOL) were evaluated at 2FU.
  
  
  RESULTS
  Resective procedures included 14 tuber resections, 9 lobectomies, and 2 tuber resections and lobectomies. Corpus callosotomies (CCTs) were performed as the adjunctive approach in eight cases with low IQ and behavioral problems. The percentages of seizure-free cases were 72% at 1FU, 60% at 2FU, and 54.5% at 5FU, and the factors predicting seizure freedom included the course of seizures and ages of patients. Significant improvement was found in performance IQ in patients with preoperative low IQ or CCT. Significant improvement in mean QOL score was observed in all patients, especially patients with preoperative low IQ and CCT but postoperative seizure freedom.
  
  
  CONCLUSIONS
  To be surgical candidates, patients with TSC and epilepsy should have identified epileptogenic tubers, and candidates should include patients with low IQ and multiple epileptogenic tubers. Satisfactory seizure control was often achieved with early operation, whereas improved QOL was observed frequently in postoperative seizure-free patients. CCT could be performed as an adjunctive approach to resective operation for TSC patients with epilepsy and low IQ and render improvement of performance IQ and QOL.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of General Hospital of PLA, Beijing, China. liangsl_304@sina.com
authors.forename: Shuli
authors.initials: S
authors.lastname: Liang
authors.forename: Anmin
authors.initials: A
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Suming
authors.initials: S
authors.lastname: Yu
authors.forename: Xiaolun
authors.initials: X
authors.lastname: Meng
authors.forename: Yajing
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D038481:Anterior Temporal Lobectomy; D002648:Child; D002681:China; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D003337:Corpus Callosum / Q000503:physiopathology / Q000601:surgery; D004827:Epilepsy / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007360:Intelligence / Q000502:physiology; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D019635:Neurosurgical Procedures; D009778:Occipital Lobe / Q000503:physiopathology / Q000601:surgery; D010348:Patient Care Team; D018579:Patient Selection; D011183:Postoperative Complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D011788:Quality of Life / Q000523:psychology; D012189:Retrospective Studies; D014402:Tuberous Sclerosis / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D055815:Young Adult