Sustained protection from pentavalent rotavirus vaccination during the second year of life at a large, urban United States pediatric hospital.
Fecal specimens from children presenting to Texas Children's Hospital with acute gastroenteritis were tested for the presence of rotavirus. Children were grouped according to vaccination status, and pentavalent rotavirus vaccine effectiveness was calculated. Pentavalent rotavirus vaccine effectiveness against severe rotavirus gastroenteritis was sustained during the first 2 years of the vaccination program. Overall 3-dose effectiveness was 83% to 86%; it was 92% to 93% among children 6 to 11 months of age and 78% to 84% among children ≥12 months of age.
Boom
Julie A
JA
Center for Vaccine Awareness and Research, Texas Children's Hospital, Houston, TX 77030, USA. jboom@bcm.edu
Tate
Jacqueline E
JE
Sahni
Leila C
LC
Rench
Marcia A
MA
Quaye
Osbourne
O
Mijatovic-Rustempasic
Slavica
S
Patel
Manish M
MM
Baker
Carol J
CJ
Parashar
Umesh D
UD
D000367:Age Factors; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000276:immunology*; D013781:Texas; D014505:Urban Population; D014613:Vaccines, Attenuated / Q000276:immunology
C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated