Lipid overaccumulation and drastic insulin resistance in adult catch-up growth rats induced by nutrition promotion after undernutrition.
This study was designed to explore the metabolic changes resulting from catch-up growth in adult (CUGA) induced by varying degrees of nutrition promotion after undernutrition and to confirm whether these changes are transient or not. The CUGA models were developed on rats refed on intakes of normal chow or high-fat diet after a period of caloric restriction. The growth of the rats measured by body weight and length stagnated during caloric restriction and then rapidly accelerated following refeeding. Catch-up growth in adult resulted in an increase in intramuscular and intrahepatic lipid content, visceral fat deposition, and insulin resistance, which is consistent with a transient rise in food efficiency during the early stage of refeeding. In addition, ectopic lipid deposition, visceral fat accumulation, and insulin resistance were more severe in rats refed the high-fat diet than rats refed the normal chow. These findings suggest that CUGA induced by rapid nutrition promotion could result in persistent lipid overaccumulation (increased visceral fat and ectopic lipid deposition) and drastic systemic insulin resistance. The effects of CUGA on metabolic characteristics are dependent on the type of diet that is used for refeeding, especially on the amount of fat intake.
Chen
Lu-Lu
LL
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. cheria_chen@126.com
Hu
Xiang
X
Zheng
Juan
J
Kong
Wen
W
Zhang
Hao-Hao
HH
Yang
Wei-Hong
WH
Zhu
Su-Ping
SP
Zeng
Tian-Shu
TS
Zhang
Jiao-Yue
JY
Deng
Xiu-Ling
XL
Hu
Di
D
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000886:Anthropometry; D050218:Body Fat Distribution; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology; D002149:Energy Intake / Q000502:physiology; D015309:Glucose Clamp Technique; D006128:Growth / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008297:Male; D044342:Malnutrition / Q000178:diet therapy / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D014280:Triglycerides; D002784:Cholesterol