Respiratory epithelial adenomatoid hamartoma: a review.
Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract first described by Wenig and Heffner in 1995 as prominent glandular proliferations lined by ciliated respiratory epithelium originating from the surface epithelium. The entity is seen most often in male adults. Clinically the lesion presents as a polypoid mass, often in one or both nasal cavities, though other locations have been described. While REAH is benign, awareness and recognition of the lesion is important because it can be easily confused grossly and microscopically with more threatening tumors such as inverted papilloma and sinonasal carcinoma. The literature of REAH is reviewed with detail paid to the histologic diagnosis. The clinical presentation, radiologic findings, and differential diagnosis are also described.
Fitzhugh
Valerie A
VA
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, University Hospital, 150 Bergen Street, Newark, NJ 07103, USA. valerie_a_fitzhugh@comcast.net
Mirani
Neena
N
D018256:Adenomatous Polyps / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D020545:Respiratory Mucosa / Q000378:metabolism / Q000473:pathology*; D012140:Respiratory Tract Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
D015415:Biomarkers