How paraproteins can affect laboratory assays: spurious results and biological effects.
The presence of large amounts of monoclonal paraprotein in the serum can lead to a range of spurious laboratory results. These may result from analytical interference of the M-protein through chemical or immunological means, or from pre-analytical interference; the different modes of interference are explored in this review along with suggested methods of prevention or detection.
King
Richard I
RI
Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand. richard.king@cdhb.govt.nz
Florkowski
Christopher M
CM
D016477:Artifacts; D001774:Blood Chemical Analysis / Q000379:methods*; D003951:Diagnostic Errors; D006801:Humans; D010265:Paraproteinemias / Q000097:blood*; D010266:Paraproteins / Q000378:metabolism*
D010266:Paraproteins