title: Polymorphisms in the AR and PSA genes as markers of susceptibility and aggressiveness in prostate cancer.
abstract: The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06–2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21–2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.
authors.affiliation: Department of General Biology, Biological Science Center, Londrina State University, Paraná, Brazil.
authors.forename: Hellen
authors.initials: H
authors.lastname: Kuasne
authors.forename: Iara Sant'Ana
authors.initials: IS
authors.lastname: Rodrigues
authors.forename: Paulo Emílio
authors.initials: PE
authors.lastname: Fuganti
authors.forename: Roberta
authors.initials: R
authors.lastname: Losi-Guembarovski
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ito
authors.forename: Marina O
authors.initials: MO
authors.lastname: Kishima
authors.forename: Marco Aurélio de Freitas
authors.initials: MA
authors.lastname: Rodrigues
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: Rogatto
authors.forename: Rodrigo Mattos dos
authors.initials: RM
authors.lastname: Santos
authors.forename: Ilce Mara de Syllos
authors.initials: IM
authors.lastname: Cólus
mesh_terms: D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017430:Prostate-Specific Antigen / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen