[Meta-analysis based on individual patient data: example of advanced colorectal cancer].
The authors mention the existing methods to perform meta-analysis, and show that meta-analysis based on individual patient data (IPD meta-analyses) are the most reliable. Taking the example of 4 successive meta-analysis of clinical trials in advanced colorectal cancer, they illustrate the possibilities of IPD meta-analysis. They conclude that meta-analysis are a powerful tool not only to confirm small differences between treatment modalities, but also to generate hypothesis, to perform exploratory subgroup analysis, and to study potential surrogate endpoints.
Piedbois
Pascal
P
AstraZeneca.
Buyse
Marc
M
D015179:Colorectal Neoplasms / Q000451:nursing*; D006801:Humans; D015201:Meta-Analysis as Topic; D015399:Nursing Research / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results