New synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of in situ generated nitrile imines and benzyne.
A new synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min, affording the corresponding N(1)-C(3) disubstituted indazoles in moderate to excellent yields.
Spiteri
Christian
C
School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
Keeling
Steve
S
Moses
John E
JE
D001555:Benzene Derivatives / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
D001555:Benzene Derivatives; D007097:Imines; D007191:Indazoles; D009570:Nitriles; C524146:benzyne