title: [Reversibility of hepatitis B virus-induced liver cirrhosis after prolonged antiviral therapy].
abstract: Reversibility of liver fibrosis or cirrhosis involves complete restoration of normal liver architecture. This phenomenon has been well documented in chronic liver diseases such as autoimmune hepatitis, biliary obstruction, hemochromatosis, nonalcoholic steatohepatitis, and viral hepatitis. There are very few reports of reversal of cirrhosis after antiviral therapy in patients with chronic hepatitis B virus (HBV) infection. We report a case of disappearance of HBV-induced liver cirrhosis after years of treatment with distinct antiviral drugs, documented by successive biopsy results. This disappearance was accompanied by normalization of platelet count, gammaglobulin titers, and radiologic findings.
authors.affiliation: Hospital General La Mancha-Centro, Alcázar de San Juan, España. perezrold@teleline.es
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez Roldán
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Vives Domínguez
authors.forename: Pedro
authors.initials: P
authors.lastname: González Carro
authors.forename: Maria Concepción
authors.initials: MC
authors.lastname: Villafáñez García
authors.forename: Maria Jesús
authors.initials: MJ
authors.lastname: Fernández Acenero
authors.forename: Rubén
authors.initials: R
authors.lastname: Cuesta Domínguez
authors.forename: Sami
authors.initials: S
authors.lastname: Aoufi Rabih
authors.forename: Francisco
authors.initials: F
authors.lastname: Ruíz Carrillo
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006509:Hepatitis B / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors
chemical_list: D000998:Antiviral Agents