title: Efficacy of PTX3 in a rat model of invasive aspergillosis.
abstract: Pentraxin 3 (PTX3) is an acute-phase glycoprotein with a nonredundant function in the host resistance to Aspergillus fumigatus. PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate. PTX3 enhanced the survival rate and reduced the lung fungal burden of infected rats in both therapeutic and prophylactic modalities. Thus, we extended the protective activity of PTX3 in pulmonary aspergillosis to corticosteroid-induced immunodeficiency, which is a relevant clinical condition in graft-versus-host disease and in solid organ transplant.
authors.affiliation: R&D Department, Sigma-Tau SpA00040 Pomezia, RM, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Lo Giudice
authors.forename: Silvia
authors.initials: S
authors.lastname: Campo
authors.forename: Antonio
authors.initials: A
authors.lastname: Verdoliva
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rivieccio
authors.forename: Franco
authors.initials: F
authors.lastname: Borsini
authors.forename: Rita
authors.initials: R
authors.lastname: De Santis
authors.forename: Giovanni
authors.initials: G
authors.lastname: Salvatori
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002097:C-Reactive Protein / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D000683:Serum Amyloid P-Component / Q000627:therapeutic use*; D000099153:Pentraxins
chemical_list: D000935:Antifungal Agents; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins