Neuroprotection by hypothermia plus alkalinization of dorsal root ganglia neurons through ischemia.
Brain and spinal cord (CNS) trauma typically directly kill some neurons leading to permanent neurological deficits. However, they also lead to a number of triggers which in turn frequently kill a vastly larger number of neurons than were killed by the initial insult. The best mechanism for reducing the extent of neurological deficits is to minimize the number of neurons that die immediately due to the trauma, and post-trauma sequelae. Neuroprotection techniques have taken many diverse forms with a breadth too great for a short review. Therefore, this review is focused on the roles of only a small number of neuroprotective agents, with its primary focus being on neuroprotection provided by hypothermia, alone and when combined with the other methods. Included are also recent results involving a novel neuroprotective technique, tested on adult human dorsal root ganglion neurons, comparing the influences of hypothermia and alkalinization singly, providing fourfold and eightfold increases in neuroprotection, respectively, but when combined providing a 26-fold increase in neuroprotection. This combinatorial approach to neuroprotection holds great promise for enhancing the degree of neuroprotection clinically following CNS trauma, leading to the preservation of maximal neurological functions.
Kuffler
Damien P
DP
Institute of Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan. dkuffler@hotmail.com
D000328:Adult; D002545:Brain Ischemia / Q000473:pathology / Q000517:prevention & control*; D005727:Ganglia, Spinal / Q000473:pathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced; D066298:In Vitro Techniques; D013116:Spinal Cord / Q000098:blood supply*