Biotransformation of bioactive (-)-mellein by a marine isolate of bacterium Stappia sp.
The biological transformation of the bioactive dihydroisocoumarin, (-)-mellein, isolated from the marine-derived fungus Cladosporium sp., was studied. The preparative-scale culture of (-)-mellein with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein. The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.
Feng
Zhile
Z
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Nenkep
Viviane
V
Yun
Keumja
K
Zhang
Dahai
D
Choi
Hong Dae
HD
Kang
Jung Sook
JS
Son
Byeng Wha
BW
D001711:Biotransformation; D002963:Cladosporium / Q000378:metabolism*; D009793:Ochratoxins / Q000737:chemistry / Q000378:metabolism*; D041902:Rhodobacteraceae / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D012623:Seawater / Q000382:microbiology*; D013237:Stereoisomerism
D009793:Ochratoxins; C120538:ochracin