title: Melasma: treatment with 10% tretinoin peeling mask.
abstract: BACKGROUND
  Melasma is one of the most frequently acquired hyperpigmentation disorders clinically characterized by symmetrical brown patches on sun exposed areas. The first approach is an avoidance of sun exposure and inflammation combined with a use of photoprotection. Patient treatment is particularly difficult and challenging, and necessitates consideration of many therapies, including tretinoin to obtain an amelioration of this important skin condition.
  
  
  OBJECTIVE
  To evaluate the efficacy of a 10% tretinoin peeling mask before and after treatment using standardized digital photos, mexameter measures, and melasma area and severity index (MASI) evaluation.
  
  
  METHODS
  The present study was carried out on 20 female patients.
  
  
  RESULTS
  Physician global evaluation showed moderate or marked improvement of melasma in all patients using three parameters of assessment: digital photography, mexameter measurement, and the MASI.
  
  
  CONCLUSIONS
  Tretinoin peeling mask can be considered an alternative treatment modality in treating melasma. We noted a particular high tolerability and efficacy without adverse events.
authors.affiliation: Department of Dermatology, University of Florence, Florence, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ghersetich
authors.forename: Michela
authors.initials: M
authors.lastname: Troiano
authors.forename: Benedetta
authors.initials: B
authors.lastname: Brazzini
authors.forename: Meena
authors.initials: M
authors.lastname: Arunachalam
authors.forename: Torello
authors.initials: T
authors.lastname: Lotti
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002615:Chemexfoliation / Q000379:methods; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage*; D008548:Melanosis / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin