Electrospray ionization tandem mass spectrometry of phosphonate peptides.
Phosphonate peptides were synthesized and investigated by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry. It was found that, for the sodiated adduct, there were two rearrangement reactions. In path A, there was C-C covalent bond cleavage with consecutive migration of a hydrogen atom to lose the amino alcohol molecule. In path B, two consecutive covalent cleavages of the C-N and P-O bonds occurred.
Zhang
Zhenyu
Z
Department of Chemistry, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China.
Liu
Yan
Y
Cai
Zenshi
Z
Zhang
Hanwen
H
Fang
Hua
H
Fang
Meijuan
M
Zhao
Yufen
Y
D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D009842:Oligopeptides; D063065:Organophosphonates