title: Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose.
abstract: The objective of the study was to investigate the effect of staged-surgery with permanent pathology on tumour recurrence of high-risk nonmelanoma skin cancers (NMSCs) of the nose and to determine the factors associated with subclinical spread and deep-margin involvement. Twenty-one patients who underwent staged-surgery with permanent pathology for high-risk NMSCs of the nose between 2007 and 2008 were prospectively followed-up for tumour recurrence. The incidence of tumour recurrence after staged-surgery with permanent pathology was 0%. A positive correlation between perineural involvement and subclinical spread (p = .012); and a statistically significant relationship between infiltrative type basal cell carcinoma (BCC) and deep-margin involvement (p = .033) was detected. Staged-surgery with permanent pathology is a reliable surgical method for complete excision of high-risk NMSCs of the nose and provides a significant decrease in tumour recurrence. Perineural involvement may cause subclinical spread, and infiltrative type BCC may invade deeper structures of the nose.
authors.affiliation: Department of Otorhinolaryngology-Head Neck Surgery, Celal Bayar University, Manisa, Turkey. gorkemeskiizmir@yahoo.com
authors.forename: Görkem
authors.initials: G
authors.lastname: Eskiizmir
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Gençoğlan
authors.forename: Peyker
authors.initials: P
authors.lastname: Temiz
authors.forename: Zafer
authors.initials: Z
authors.lastname: Hirçin
authors.forename: Aylin
authors.initials: A
authors.lastname: Ermertcan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013524:Surgical Flaps; D016896:Treatment Outcome