title: Combined moxidectin and environmental therapy do not eliminate Chorioptes bovis infestation in heavily feathered horses.
abstract: Chorioptes bovis infestation is a common cause of pastern dermatitis in the horse, with a predilection in draft horses and other horses with thick hair 'feathers' on the distal limbs. The treatment of this superficial mite is challenging; treatment failure and relapse are common. Furthermore, C. bovis infestation may affect the progression of chronic pastern dermatitis (also known as chronic proliferative pastern dermatitis, chronic progressive lymphoedema and dermatitis verrucosa) in draft horses, manifesting with oedema, lichenification and excessive skin folds that can progress to verruciform lesions. An effective cure for C. bovis infestation would therefore be of great clinical value. In a prospective, double-blind, placebo-controlled study, the efficacy of oral moxidectin (0.4 mg/kg body weight) given twice with a 3 week interval in combination with environmental treatment with 4-chloro-3-methylphenol and propoxur was tested in 19 heavily feathered horses with clinical pastern dermatitis and C. bovis infestation. Follow-up examinations over a period of 180 days revealed significantly more skin crusting in the placebo group than in the treatment group. However, no other differences in clinical signs or the numbers of mites detected were found between the two groups. The results of this study suggest that moxidectin in combination with environmental insecticide treatment as used in this study is ineffective in the treatment of C. bovis in feathered horses.
authors.affiliation: Dermatology Unit, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Berne, Switzerland. silvia.ruefenacht@itz.unibe.ch
authors.forename: Silvia
authors.initials: S
authors.lastname: Rüfenacht
authors.forename: Petra J
authors.initials: PJ
authors.lastname: Roosje
authors.forename: Heinz
authors.initials: H
authors.lastname: Sager
authors.forename: Marcus G
authors.initials: MG
authors.lastname: Doherr
authors.forename: Reto
authors.initials: R
authors.lastname: Straub
authors.forename: Pamela
authors.initials: P
authors.lastname: Goldinger-Müller
authors.forename: Vincent
authors.initials: V
authors.lastname: Gerber
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D003408:Cresols / Q000494:pharmacology; D005121:Extremities; D005260:Female; D006197:Hair; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007306:Insecticides / Q000627:therapeutic use*; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D001074:Propoxur / Q000494:pharmacology; D040042:Psoroptidae
chemical_list: D003408:Cresols; D007306:Insecticides; D018942:Macrolides; C006984:chlorocresol; D001074:Propoxur; C027837:moxidectin