title: Interproximal periodontal defect model in dogs: a pilot study.
abstract: OBJECTIVE
  This study aimed to evaluate the validity of a surgically created interproximal periodontal defect in dogs.
  
  
  METHODS
  Surgery was performed in the interproximal area between the maxillary second and third premolars in two beagle dogs. Following an incision and reflection of the gingival flap, a 3-mm wide and 5-mm high defect was prepared surgically at the interproximal area. A thorough root planing was performed and the flap was coronally positioned and sutured. The contra-lateral area was served as the control with no surgical intervention. After 8 weeks of healing, the animals were killed and the defect was analysed histometrically and radiographically.
  
  
  RESULTS
  The interproximal periodontal defect resembled a naturally occurring defect and mimicked a clinical situation. After healing, the defect showed limited bone (0.89±0.02mm) and cementum regeneration (1.50± 0.48mm).
  
  
  CONCLUSIONS
  Within the limitations of this pilot study, the interproximal periodontal defect showed limited bone and cementum regeneration. Thus, it can be considered as a standardized, reproducible defect model for testing new biomaterials.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: U-W
authors.initials: UW
authors.lastname: Jung
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Chang
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Um
authors.forename: C-S
authors.initials: CS
authors.lastname: Kim
authors.forename: K-S
authors.initials: KS
authors.lastname: Cho
authors.forename: S-H
authors.initials: SH
authors.lastname: Choi
mesh_terms: D016301:Alveolar Bone Loss / Q000150:complications / Q000601:surgery*; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D003739:Dental Cementum / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D008297:Male; D008437:Maxilla; D010510:Periodontal Diseases / Q000150:complications / Q000601:surgery*; D010519:Periodontium / Q000502:physiology / Q000601:surgery; D010865:Pilot Projects; D012038:Regeneration / Q000502:physiology; D016745:Root Planing; D013524:Surgical Flaps; D014945:Wound Healing / Q000502:physiology*