title: [An in vitro study of anti-human cytomegalovirus effect of Forsythia suspensa and its main active ingredient quercetin].
abstract: OBJECTIVE
  To study the in vitro anti-human cytomegalovirus effect and the cytotoxicity of Forsythia suspensa and its main active ingredient quercetin.
  
  
  METHODS
  The 0% toxic dose (TD0), minimum effective concentration (MEC) and therapeutic index (TI) of anti-human cytomegalovirus activity by F. suspensa and quercetin were detected with the cytopathic assay and MTT method. Ganciclovir was used as the control drug for comparison.
  
  
  RESULTS
  The TD0 of ganciclovir, F. suspensa and quercetin were 10, 30, 30 mg L(-1), the MEC were 10, 30, 0.3 mg x L(-1), TI were 1, 1 and 100, respectively.
  
  
  CONCLUSIONS
  The anti-human cytomegalovirus effect of quercetin is much higher than ganciclovir and F. suspensa, and the cytotoxicity is equivalent to F. suspensa but lower than ganciclovir. Therefore, quercetin has the potential advantages of anti-human cytomegalovirus effect.
authors.affiliation: Department of Obstetrics and Gynecology, Tongli Hospital Affiliated with Tongfi Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. beautyzdandan@yahoo.com.cn
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Fang
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Chen
authors.forename: Jin
authors.initials: J
authors.lastname: Wan
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zongzhi
authors.initials: Z
authors.lastname: Yin
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Suhua
authors.initials: S
authors.lastname: Chen
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D031657:Forsythia / Q000737:chemistry*; D006801:Humans; D011794:Quercetin / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D011794:Quercetin