MTERF1 gives mtDNA an unusual twist.
Expression of mtDNA is critical for biogenesis of the oxidative phosphorylation system, but the regulatory processes are poorly understood. Recent work in Cell (Yakubovskaya et al., 2010) reports a novel DNA-binding fold in mitochondrial transcription termination factor 1 (MTERF1), which causes unwinding and base eversion at its target mtDNA sequence.
Gustafsson
Claes M
CM
Department of Biochemistry and Cell Biology, Göteborgs Universitet, S-405 30 Göteborg, Sweden. claes.gustafsson@medkem.gu.se
Larsson
Nils-Göran
NG