title: Pain relief after Frey's procedure for chronic pancreatitis.
abstract: BACKGROUND
  Few studies have addressed long-term pain relief after Frey's procedure (local head resection with lateral pancreaticojejunostomy, LR-LPJ) for chronic pancreatitis. This retrospective study evaluated pain control using a validated score and risk factors associated with failure to achieve complete pain relief following LR-LPJ.
  
  
  METHODS
  Sixty of 134 patients with chronic pancreatitis underwent LR-LPJ and were evaluated prospectively using the Izbicki pain score before surgery, and 1, 2, 5 and 7 years later. Analysis was on an intention-to-treat basis and predictors of complete pain relief were identified by multivariable analysis.
  
  
  RESULTS
  After a median follow-up of 6.4 years, the median pain score was reduced from 46.4 to 10.0 (P < 0.001) with partial or complete pain relief in 75 per cent of patients, and a significant reduction in median number of episodes requiring hospitalization (from 4 to 0; P < 0.001). Preoperative use of opiate medication (odds ratio (OR) 30.14; P = 0.015), continuous pattern of pain (OR 22.65; P = 0.025) and occurrence of postoperative complications (OR 10.52; P = 0.030) were significant predictors of failure to achieve complete pain relief after surgery.
  
  
  CONCLUSIONS
  Frey's procedure leads to significant and sustained long-term pain relief in patients with chronic pancreatitis. Patients should be referred for surgery before opiates are needed to relieve pain.
authors.affiliation: Department of Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital, New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Negi
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Chaudhary
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010193:Pancreaticojejunostomy; D050500:Pancreatitis, Chronic / Q000209:etiology / Q000601:surgery*; D011446:Prospective Studies; D012008:Recurrence; D012086:Reoperation; D018570:Risk Assessment; D024162:Second-Look Surgery; D016896:Treatment Outcome