gp130 at the nexus of inflammation, autoimmunity, and cancer.
Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp130-deficient mice are embryonically lethal. However, the best characterized facet of this receptor and its associated cytokines is the ability to promote or suppress inflammation. The aim of this review is to discuss the role of gp130 in promoting or preventing the development of autoimmunity and cancer, two processes that are associated with aberrant inflammatory responses.
Silver
J S
JS
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19143, USA.
Hunter
C A
CA
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001249:Asthma / Q000276:immunology; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D050822:Cytokine Receptor gp130 / Q000502:physiology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology*; D015850:Interleukin-6 / Q000502:physiology; D009369:Neoplasms / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000502:physiology; D000093242:Interleukin-6 Inhibitors
D050822:Cytokine Receptor gp130; D015850:Interleukin-6; D050791:STAT Transcription Factors; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D000093242:Interleukin-6 Inhibitors; C106644:SOCS3 protein, human