Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus.
OBJECTIVE
To evaluate the frequency of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (DM2) and to describe its risk factors.


METHODS
Blood samples of 78 patients were collected for assessment of glycemic and lipid profile, liver enzymes, TNF-alpha and HOMA-IR. The diagnosis of NAFLD was established by ultrasound.


RESULTS
NAFLD was observed in 42% of patients who had greater BMI (p < 0.001), and frequency of hypertension (p < 0.001). Metabolic syndrome was more frequent in those with NAFLD (p = 0.019). The levels of aspartate, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, TNF-alpha, insulin and HOMA-IR were significantly higher in patients with NAFLD than those without NAFLD.


CONCLUSIONS
Almost half of patients with DM2 were found to have NAFLD, and they have more elevated BMI, as well as higher levels of aminotransferases, gamma-GT, uric acid, TNF-alpha, insulin and HOMA-IR than subjects without NAFLD.
Ferreira
Vera S G
VS
Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Recife, PE, Brazil. verasgf@hotmail.com
Pernambuco
Ricardo B
RB
Lopes
Edmundo P
EP
Morais
Clarice N
CN
Rodrigues
Marbiana C
MC
Arruda
Maria Juliana
MJ
Silva
Lidiane Moura E
LM
Vilar
Lucio
L
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005234:Fatty Liver / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D000637:Transaminases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D000637:Transaminases