title: Prediction of mortality after radical prostatectomy by Charlson comorbidity index.
abstract: OBJECTIVE
  Prostate cancer treatment should depend on the characteristics of a patient's prostate cancer as well as overall health status. A possible adverse consequence of poor patient selection is a lack of benefit because of premature death from another cause. We evaluated the association between perioperative comorbidity and risk of death from causes other than prostate cancer in men who underwent radical prostatectomy (RP).
  
  
  METHODS
  We conducted a retrospective cohort study of 14,052 men who underwent RP from 1983 to 2006. The Charlson Comorbidity Index (CCI) score was calculated using the discharge records for the prostatectomy hospitalization. Mortality status and cause of death were obtained via chart review and searches of national databases. Cox proportional hazards regression was used to estimate the hazard ratio (HR) of death from causes other than prostate cancer after RP by CCI score (0, 1, 2+).
  
  
  RESULTS
  The median age at RP was 58.1 years. The median follow-up was 7.6 years (interquartile range 4.3-11.5). Of 849 deaths, 599 (70.6%) resulted from causes other than prostate cancer. On multivariable analysis, men with a CCI ≥2 had a statistically significantly higher risk of death from causes other than prostate cancer compared with those with lower CCI scores (HR 2.18, 95% CI 1.30-3.64, P = .0003).
  
  
  CONCLUSIONS
  Greater perioperative comorbidity was associated with a higher risk of death from causes other than prostate cancer in men who underwent RP. Physicians should consider using a standardized tool to assess perioperative comorbidities to enhance appropriate recommendation for surgical treatment.
authors.affiliation: The James Buchanan Brady Urological Institute, the Johns Hopkins Medical Institutions, Baltimore, MD, USA. tjguzzo@gmail.com
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Guzzo
authors.forename: Paul
authors.initials: P
authors.lastname: Dluzniewski
authors.forename: Ryan
authors.initials: R
authors.lastname: Orosco
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Platz
authors.forename: Alan W
authors.initials: AW
authors.lastname: Partin
authors.forename: Misop
authors.initials: M
authors.lastname: Han
mesh_terms: D015331:Cohort Studies; D015897:Comorbidity; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000601:surgery*; D012189:Retrospective Studies