Functional asymmetry of the cerebral hemispheres: its role in the pathogenesis of ectromelia and melanoma in (CBAxC57BL/6)F1 mice.
The aim of the present work was to identify the role of functional asymmetry in the cerebral hemispheres in the pathogenesis of infectious and oncological pathology in (CBAxC57BL/6)F1 mice. Mice with lefthemisphere dominance of motor functions ("right-handers") were found to be more resistant to infection with ectromelia virus and to show slower growth of tumors after subcutaneous injection of B-16 melanoma than animals with right-hemisphere dominance of motor control ("left-handers"). Thus, this report provides the first evidence for the role of functional asymmetry of the nervous system in the pathogenesis of ectromelia and melanoma (B-16) in (CBAxC57BL/6)F1 mice.
Abramov
V V
VV
State Research Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, 14 Yadrintsevskaya St., 630099, Novosibirsk, Russia. valery_abramov@mail.ru
Gontova
I A
IA
Ignatiev
I M
IM
Gelfgat
E L
EL
Kozlov
V A
VA
D000818:Animals; D004482:Ectromelia, Infectious / Q000503:physiopathology*; D007839:Functional Laterality; D008297:Male; D008546:Melanoma, Experimental / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000502:physiology*; D009368:Neoplasm Transplantation