Successful treatment of vancomycin-resistant Enterococcus faecium ventriculitis with combined intravenous and intraventricular chloramphenicol in a newborn.
Vancomycin-resistant Enterococcus faecium (VRE) infection is a rare event in paediatric patients and often occurs under immunosuppression or after surgical intervention. We report what we believe to be the first paediatric case of ventriculitis due to VRE (in a 2-month-old infant) to be successfully treated with combined intravenous (i.v.) and intraventricular chloramphenicol after failure of i.v. linezolid and intraventricular gentamicin.
Hartmann
Carolin
C
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Peter
Corinna
C
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Hermann
Elvis
E
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Ure
Benno
B
Department of Pediatric Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Sedlacek
Ludwig
L
Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Hansen
Gesine
G
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Bohnhorst
Bettina
B
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
D000081:Acetamides / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002552:Cerebral Ventricles / Q000382:microbiology* / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000382:microbiology; D002701:Chloramphenicol / Q000008:administration & dosage*; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy; D016984:Enterococcus faecium / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007276:Injections, Intraventricular; D000069349:Linezolid; D008161:Lumbosacral Region / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D023303:Oxazolidinones / Q000008:administration & dosage; D010388:Pelvis / Q000000981:diagnostic imaging; D011859:Radiography; D016896:Treatment Outcome; D020713:Vancomycin Resistance
D000081:Acetamides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D023303:Oxazolidinones; D002701:Chloramphenicol; D000069349:Linezolid