title: [Plasma fibroblast growth factor-21 and abdominal obesity].
abstract: OBJECTIVE
  To investigate the association of plasma fibroblast growth factor-21 (FGF-21) with abdominal obesity and other metabolic indicators.
  
  
  METHODS
  Sixty one people with abdominal obesity and 113 healthy controls were recruited. The stature, avoirdupois, waist circumference and blood pressure of the participants were measured. Serum lipid, glucose, insulin and plasma FGF-21 levels of those participants were also determined.
  
  
  RESULTS
  1) The participants with abdominal obesity had significantly higher FGF-21 levels than the healthy controls [(1.91 +/- 0.40) ng/mL vs. (1.75 +/- 0.45) ng/mL, P = 0.020]. 2) Plasma FGF-21 levels were positively associated with BMI (r = 0.24, P = 0.001), waist circumference (r = 0.16, P = 0.033), body fat contents (r = 0.24, P = 0.001), and triglycerides (r = 0.16, P = 0.036) after adjustment for age and sex. The multiple liner regression analysis identified BMI, waist circumference, body fat contents, and triglycerides as factors associated with FGF-21 (P < 0.05). 3) Plasma FGF-21 levels were found to be independently associated with abdominal obesity (OR = 2.413, 95% CI 1.115-5.221, P = 0.025).
  
  
  CONCLUSIONS
  FGF-21 is an independent risk factor for abdominal obesity. It is perhaps an important factor in the occurrence and development of abdominal obesity.
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Zhong-Yun
authors.initials: ZY
authors.lastname: Xiong
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: You-Juan
authors.initials: YJ
authors.lastname: Wang
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Huang
authors.forename: Zhen-Mei
authors.initials: ZM
authors.lastname: An
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood*; D012307:Risk Factors
chemical_list: D008055:Lipids; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors