HIF-1alpha partners with FoxA2, a neuroendocrine-specific transcription factor, to promote tumorigenesis.
In this issue of Cancer Cell, Qi et al. report a novel mechanism by which HIF-1alpha synergizes with a tissue-specific transcription factor, FoxA2, to promote a transcriptional program that supports prostate tumor formation and progression.
Eisinger-Mathason
T S Karin
TS
School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Simon
M Celeste
MC