Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study.
Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on threat intensity in patients with generalized social phobia (GSP) and healthy controls. GSP patients exhibited greater amygdala reactivity to threat faces at high and moderate intensities. More subtle displays of social threat are sufficient to evoke a fear-related neural response.
Klumpp
Heide
H
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109-2700, United States. heidek@umich.edu
Angstadt
Mike
M
Nathan
Pradeep J
PJ
Phan
K Luan
KL
D000328:Adult; D000679:Amygdala / Q000098:blood supply*; D001931:Brain Mapping; D005145:Face; D005149:Facial Expression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010698:Phobic Disorders / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D010775:Photic Stimulation / Q000379:methods; D055815:Young Adult
D010100:Oxygen