Unexpected interaction between quetiapine and valproate in patients with bipolar disorder.
Quetiapine, a second-generation antipsychotic originally used in the treatment of schizophrenia, was also found to be effective as monotherapy or as an adjunctive therapy for acute mania. Delirium in patients treated with quetiapine seems to be a rare phenomenon; however, we report two patients with bipolar disorder who developed delirium when prescribed quetiapine as an adjunct to valproate for acute mania. Both had previously developed mild renal insufficiency after an episode of lithium intoxication. The delirium resolved after quetiapine was discontinued. Unexpected interactions may occur when medications are combined without being subject to controlled clinical trials.
Huang
Chih-Chia
CC
Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan. chihchiahuang@yahoo.com.tw
Wei
I-Hua
IH
D001714:Bipolar Disorder / Q000188:drug therapy*; D003693:Delirium / Q000139:chemically induced; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069348:Quetiapine Fumarate; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D014635:Valproic Acid