title: Protein kinase C/mitogen-activated protein kinase signaling in keratinocyte differentiation control.
abstract: Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is altered in many common skin diseases. Keratinocyte differentiation is controlled by a complex signaling network involving multiple members of the protein kinase C and mitogen-activated protein kinase signaling kinases. Using an RNA interference knockdown approach, Adhikary et al. identified essential nodes in this signaling network, revealing remarkable kinase specificity.
authors.affiliation: Department of Pathology and the Cardinal Bernardin Cancer Center, Skin Cancer Research Program, Loyola University Chicago, Maywood, Illinois 60153, USA. mdennin@lumc.edu
authors.forename: Mitchell F
authors.initials: MF
authors.lastname: Denning
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011493:Protein Kinase C; D020928:Mitogen-Activated Protein Kinases