title: Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects.
abstract: We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.
authors.affiliation: ICFO-Institut de Ciencies Fotoniques, Av Canal Olimpic s/n, Castelldefels 08860, Spain. durduran@alumni.upenn.edu
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Erin M
authors.initials: EM
authors.lastname: Buckley
authors.forename: Meeri N
authors.initials: MN
authors.lastname: Kim
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Spray
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Durning
authors.forename: Stefanie E
authors.initials: SE
authors.lastname: Mason
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Montenegro
authors.forename: Susan C
authors.initials: SC
authors.lastname: Nicolson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Zimmerman
authors.forename: Mary E
authors.initials: ME
authors.lastname: Putt
authors.forename: Jiongjiong
authors.initials: J
authors.lastname: Wang
authors.forename: Joel H
authors.initials: JH
authors.lastname: Greenberg
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Licht
mesh_terms: D002245:Carbon Dioxide / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply*; D006330:Heart Defects, Congenital / Q000097:blood* / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D055095:Optics and Photonics / Q000379:methods*; D010108:Oxyhemoglobins / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; C100003:deoxyhemoglobin