PriorsEditor: a tool for the creation and use of positional priors in motif discovery.
CONCLUSIONS
Computational methods designed to discover transcription factor binding sites in DNA sequences often have a tendency to make a lot of false predictions. One way to improve accuracy in motif discovery is to rely on positional priors to focus the search to parts of a sequence that are considered more likely to contain functional binding sites. We present here a program called PriorsEditor that can be used to create such positional priors tracks based on a combination of several features, including phylogenetic conservation, nucleosome occupancy, histone modifications, physical properties of the DNA helix and many more.


BACKGROUND
PriorsEditor is available as a web start application and downloadable archive from http://tare.medisin.ntnu.no/priorseditor (requires Java 1.6). The web site also provides tutorials, screenshots and example protocol scripts.
Klepper
Kjetil
K
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. kjetil.klepper@ntnu.no
Drabløs
Finn
F
D000465:Algorithms; D020816:Amino Acid Motifs / Q000235:genetics; D001665:Binding Sites / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014157:Transcription Factors / Q000235:genetics*
D014157:Transcription Factors