Reference value for cardiac troponin I in a multi-ethnic group.
OBJECTIVE
The aim of this study was to evaluate the distribution of cardiac troponin I (cTnI) values, measured by the ADVIA TnI-Ultra method in a multi-ethnic group and to determine the imprecision of the assay.


METHODS
The study population comprised 234 men and 208 women and the age range was 18-73 years. Recruitment was aimed at enrolling different races and comprised 186 Malays, 136 Chinese and 120 Indians. We evaluated the analytical performance the ultra sensitive cardiac troponin I (cTnI) assay.


RESULTS
The mean values for cTnI for male and female were 0.011 microg/L and 0.010 microg/L respectively. No significant difference was noted between male and female populations (p > 0.05). The 99th percentile for ADVIA TnI-Ultra was 0.061 microg/L. The mean values of cTn in Malay, Chinese and Indian groups were 0.011, 0.011 and 0.011 microg/L, respectively. There was no significant difference between the different ethnic populations (p > 0.05). The assay imprecision was less than 10% at concentrations higher than 0.036 microg/L.


CONCLUSIONS
ADVIA TnI-Ultra assay showed no difference in the troponin values among different ethnic groups and between males and females. Hence a single cut-off value based on the 99th percentile can be used.
Sthaneshwar
Pavai
P
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. pavai@um.edu.my
Jamaluddin
Farhi Ain
FA
Fan
Yap Sook
YS
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000208:ethnology*; D012016:Reference Values; D015203:Reproducibility of Results; D019210:Troponin I / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D019210:Troponin I