title: Long-term compliance of salt restriction and blood pressure control status in hypertensive outpatients.
abstract: The purpose of the present study was to investigate the long-term compliance with salt restriction and blood pressure (BP) control status in Japanese hypertensive outpatients. Subjects included 103 patients, 59 women and 44 men, mean age 67 +/- 9 years, who underwent successful 24-h home urine collection more than 10 times over an interval of 5 years. Urinary salt, potassium, and creatinine were measured. During the follow-up period (average 8.6 years), participants underwent urine collection 11.4 times in average. Urinary salt excretion at the last visit was significantly lower than that of the first visit (8.2 +/- 3.1 vs. 9.6 +/- 3.7 g/day; p < 0.01). The achievement of urinary salt excretion <6 g/day increased from 18.5% at the first visit to 26.2% at the last visit. Similarly, BP at the last visit was significantly lower than that of the first visit (130 +/- 14/69 +/- 11 vs. 145 +/- 17/86 +/- 12 mmHg; p < 0.01). The achievement rate of BP <140/90 mmHg and <130/85 mmHg also increased significantly during this period (39.2% to 70.8% and 13.7% to 39.6%, respectively, p < 0.01). Results suggest that urinary salt excretion decreased by repeated measurements using 24-h home urine collection. Lifestyle modification including weight loss as well as the intensive antihypertensive treatment contributed to the improved BP control during this period.
authors.affiliation: Division of Hypertension, Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan. yukoo@qmed.hosp.go.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ohta
authors.forename: Takuya
authors.initials: T
authors.lastname: Tsuchihashi
authors.forename: Uran
authors.initials: U
authors.lastname: Onaka
authors.forename: Eri
authors.initials: E
authors.lastname: Miyata
mesh_terms: D000368:Aged; D000465:Algorithms; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D003404:Creatinine / Q000652:urine; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000178:diet therapy* / Q000188:drug therapy / Q000652:urine*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D010349:Patient Compliance; D010353:Patient Education as Topic; D011188:Potassium / Q000652:urine; D012189:Retrospective Studies; D012965:Sodium Chloride / Q000652:urine; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000959:Antihypertensive Agents; D012965:Sodium Chloride; D003404:Creatinine; D011188:Potassium