A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids.
A novel one-pot method was developed for the synthesis of the title compounds starting from 4-chloro-1-aryl-1-butanones 1, phosphorus trichloride and acetic acid. The end products 2 were obtained in 20-94% yield. The cyclization step under acidic conditions probably occurs as a result of anchimeric assistance of the phosphonic acid group.
Komissarov
Vsevolod V
VV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St., 32, Moscow 119991, Russia.
Kritzyn
Anatoly M
AM
Vepsäläinen
Jouko J
JJ