Neurochemical measures co-vary with personality traits: forensic psychiatric findings replicated in a general population sample.
Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum concentrations of beta-trace protein (betaTP) (as markers for blood-brain barrier (BBB) permeability), to CSF/serum albumin ratios between the dopamine and serotonin metabolites homovanillic acid (HVA)/5-hydroxyindoleacetic acid (HIAA) and to CSF and serum ratios between activated thyroid hormone (T3) and its precursor T4. Serum betaTP concentrations correlated with CSF/serum albumin ratios (P=0.018), but not with preoperative serum creatinine concentrations. Serum betaTP correlated significantly with Monotony Avoidance and Impulsiveness; CSF HVA/5-HIAA ratios with Irritability and low Cooperativeness. The betaTP is a potential serum marker for the integrity of the BBB that does not necessitate lumbar puncture. Thyroid hormones did not correlate with personality traits. As reported in forensic psychiatric patients, aggressive, unempathic personality traits were thus associated with increased dopaminergic activity in relation to the serotonergic activity and impulsivity to increased BBB permeability also in a general population group.
Nilsson
Thomas
T
Institute of Neuroscience and Physiology, University of Gothenburg, Sweden.
Bromander
Sara
S
Anckarsäter
Rolf
R
Kristiansson
Marianne
M
Forsman
Anders
A
Blennow
Kaj
K
Zetterberg
Henrik
H
Anckarsäter
Henrik
H
Wass
Caroline
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018672:Community Health Planning; D003404:Creatinine / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D005555:Forensic Psychiatry; D006719:Homovanillic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D019746:Intramolecular Oxidoreductases / Q000097:blood / Q000134:cerebrospinal fluid; D007717:Knee / Q000601:surgery; D054834:Lipocalins / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009448:Neurochemistry; D010551:Personality; D010555:Personality Inventory; D012709:Serum Albumin / Q000378:metabolism; D013963:Thyroid Hormones / Q000134:cerebrospinal fluid
D054834:Lipocalins; D012709:Serum Albumin; D013963:Thyroid Hormones; D006897:Hydroxyindoleacetic Acid; D003404:Creatinine; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase; D006719:Homovanillic Acid