Medication issues in older individuals with CKD.
Older US adults bear a substantial burden of chronic disease and take an average of five prescription and non-prescription medications per day. Recent data suggest that over 20% of older adults have chronic kidney disease (CKD) as defined by an impaired glomerular filtration rate. These individuals often have multiple comorbidities, including diabetes, hypertension, and cardiovascular disease. Although patients with CKD may receive substantial benefits from prescribed medications, they are also at high risk for adverse drug events and polypharmacy. In this review, we outline the risks and benefits of medication use in the CKD population as a specific case within geriatric pharmacoepidemiology as a framework.
Rifkin
Dena E
DE
Veterans' Affairs Medical Center, San Diego, CA, USA.
Winkelmayer
Wolfgang C
WC
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000627:therapeutic use; D002908:Chronic Disease; D004363:Drug Utilization / Q000706:statistics & numerical data; D005919:Glomerular Filtration Rate; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007674:Kidney Diseases / Q000150:complications* / Q000453:epidemiology; D055553:Prescription Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D000700:Analgesics; D000959:Antihypertensive Agents; D002317:Cardiovascular Agents; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D055553:Prescription Drugs; D011619:Psychotropic Drugs