Plasma carbonic anhydrase II protein is elevated in Alzheimer's disease.
Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.
Jang
Bong Geom
BG
Division of Brain Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Korea.
Yun
Sang-Moon
SM
Ahn
Kyungsook
K
Song
Ju Hee
JH
Jo
Sangmee A
SA
Kim
Young-Yul
YY
Kim
Doh Kwan
DK
Park
Moon Ho
MH
Han
Changsu
C
Koh
Young Ho
YH
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D000704:Analysis of Variance; D015153:Blotting, Western; D024402:Carbonic Anhydrase II / Q000097:blood*; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
D024402:Carbonic Anhydrase II