Laboratory methods and management of patients with heparin-induced thrombocytopenia.
The clinical effects of heparin are meritorious and heparin remains the anticoagulant of choice for most clinical needs. However, as with any drug, adverse effects exist. Heparin-induced thrombocytopenia (HIT) is an important adverse effect of heparin associated with amputation and death due to thrombosis. Although the diagnosis and treatment of HIT can be difficult and complex, it is critical that patients with HIT be identified as soon as possible to initiate early treatment to avoid thrombosis.
Prechel
Margaret
M
Department of Pathology, Stritch School of Medicine, Loyola University, Maywood, IL, USA.
Jeske
Walter P
WP
Walenga
Jeanine M
JM
D000818:Animals; D019411:Clinical Laboratory Techniques / Q000379:methods*; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D013917:Thrombin / Q000037:antagonists & inhibitors; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*
D065427:Factor Xa Inhibitors; D006493:Heparin; D013917:Thrombin