Human adipose tissue-derived adult stem cells can lead to multiorgan engraftment.
Recent studies have demonstrated the existence of a population of adipose tissue-derived adult stem cells that can undergo multilineage differentiation in vitro; however, it is unclear whether these cells maintain their multilineage differentiation in vivo. The objective of the present study was to examine the in vivo characteristics and behavior of a potential population of human adipose tissue-derived adult stem cells. Herein, we demonstrate that human adipose tissue-derived adult stem cells differentiate into the epithelium of the gastrointestinal tract, liver, and bronchi, and an endothelial lineage after transplantation into irradiated nonobese mice with diabetes or severe combined immunodeficiency. These findings may contribute to clinical tissue repair after injury.
Fang
B
B
Center of Excellence in Tissue Engineering, Henan Tumor Hospital, Henan Institute of Technology, Zhengzhou University, Zhengzho, China.
Li
Y
Y
Song
Y
Y
Li
N
N
Cao
Y
Y
Wei
X
X
Lin
Q
Q
Zhao
R C
RC
D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D002469:Cell Separation / Q000379:methods; D017931:DNA Primers; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000235:genetics; D015187:Lipectomy; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012709:Serum Albumin / Q000235:genetics; D016511:Severe Combined Immunodeficiency / Q000601:surgery; D033581:Stem Cell Transplantation / Q000379:methods*; D014183:Transplantation, Heterologous / Q000502:physiology
D017931:DNA Primers; D012709:Serum Albumin; D007633:Keratins