title: Intraoperative administration of clevidipine to prevent vasospasm after radial and internal mammary artery grafts during coronary artery bypass grafting.
abstract: During coronary artery bypass graft surgery, various arterial and venous conduits have been used to carry blood flow from the aorta to the coronary vasculature. Arterial conduits provide certain advantages over the saphenous vein, including superior long-term patency, relative resistance to the development of atherosclerosis, and greater endothelium-dependent relaxation. However, the perioperative release of catecholamines and thromboxane A, mechanical manipulation, and underlying endothelial cell dysfunction may result in vasoconstriction or vasospasm of the arterial conduit and a compromise of myocardial perfusion. Given these issues, pharmacologic therapy is frequently initiated intraoperatively to prevent vasospasm. Clevidipine is a rapidly acting calcium channel antagonist. Like nicardipine, it is a member of the dihydropyridine subgroup. Its rapid metabolism by tissue and plasma esterases results in an effective half-life of 1 to 3 minutes. We report, for the first time, the perioperative use of clevidipine to prevent vasospasm after coronary artery bypass graft surgery with the use of internal mammary artery and bilateral radial artery conduits. Its potential application in this scenario and advantages when compared with other commonly used agents is discussed.
authors.affiliation: Department of Anesthesiology, University of Missouri, Columbia, USA.
authors.forename: Mitesh
authors.initials: M
authors.lastname: Patel
authors.forename: Thomas
authors.initials: T
authors.lastname: Meyer
authors.forename: Ajit
authors.initials: A
authors.lastname: Tharakan
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001026:Coronary Artery Bypass / Q000379:methods*; D003329:Coronary Vasospasm / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006207:Half-Life; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008323:Mammary Arteries / Q000637:transplantation; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017534:Radial Artery / Q000637:transplantation
chemical_list: D002121:Calcium Channel Blockers; D011725:Pyridines; C118563:clevidipine