title: Pemetrexed pathway-associated germline polymorphisms: a useful tool for treatment individualization?
authors.forename: Wieneke A
authors.initials: WA
authors.lastname: Buikhuisen
authors.forename: Jacobus A
authors.initials: JA
authors.lastname: Burgers
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Vincent
authors.forename: Jan H M
authors.initials: JH
authors.lastname: Schellens
authors.forename: Jos H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: Egbert F
authors.initials: EF
authors.lastname: Smit
authors.forename: Markus
authors.initials: M
authors.lastname: Joerger
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D017322:Clinical Trials, Phase II as Topic; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D005820:Genetic Testing; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D018579:Patient Selection; D000068437:Pemetrexed; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine