Predictors of minimal hepatic encephalopathy in patients with cirrhosis.
OBJECTIVE
Minimal hepatic encephalopathy (MHE) impairs patient's daily functioning of life. Predictors of MHE in cirrhotic patients have not been evaluated.


METHODS
A total of 200 cirrhotic patients (Child A, 74 [37%]; Child B, 72 [36%]; Child C, 54 [27%]) were evaluated by psychometry, P300 auditory event-related potential (P300ERP) and critical flicker frequency (CFF). MHE was diagnosed by abnormal psychometry (>2 S.D.) and P300ERP (>2.5 S.D.). Univariate and multivariate logistic regression analyses were performed to determine the predictors of MHE.


RESULTS
Eighty-two (41%) patients were diagnosed to have MHE - 26/74 (35%) in Child A, 26/72 (36%) in Child B and 30/54 (56%) in Child C. Ninety-seven (48.5%) patients had abnormal psychometric tests, and 96 (48%) had prolonged P300ERP (>358 ms). Sixteen (16.5%) patients with abnormal psychometry had P300ERP < 358 ms, and 15 (14.5%) patients with normal psychometry results had P300ERP > 358 ms. One hundred and three patients had CFF value < 39 Hz with specificity of 86.6% and sensitivity of 72.9% for MHE. Model for end-stage liver disease (MELD) (17.9 +/- 5.7 vs. 13.4 +/- 4.2, P = 0.005), Child-Turcotte-Pugh (CTP) score (8.4 +/- 2.5 vs. 7.7 +/- 2.2, P = 0.02), ammonia (104.8 +/- 37.9 vs. 72.5 +/- 45.2 micromol/L, P = 0.001) and CFF (37.0 +/- 2.8 vs. 41.0 +/- 3.4 Hz, P = 0.001) were significantly higher in MHE as compared to non-MHE patients. Ninety-one (45.5%) patients had MELD > 15.5, 115 (57.5%) had CTP score > 7.5, while 93 (46.5%) had venous ammonia > 84.5 micromol/L. On univariate analysis, MELD (8.52 [95% CI, 4.46-16.26; P = 0.001]), CFF (17.34 [95% CI, 8.16-36.85; P = 0.001]) and venous ammonia (7.80 [95% CI, 4.11-14.81; P = 0.003]) were associated with MHE; while CTP score (1.51 [95% CI, 0.85-2.69; P = 0.30]) was not significant. On multivariate analysis, MELD, CFF and venous ammonia were predictive of MHE.


CONCLUSIONS
Prevalence of MHE in this study was 41%; and MELD > 15.5, CFF < 39 Hz and venous ammonia > 84.5 micromol/L were predictive of MHE.
Sharma
Praveen
P
Department of Gastroenterology, G. B. Pant Hospital, New Delhi, India.
Sharma
Barjesh C
BC
D000328:Adult; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005260:Female; D005425:Flicker Fusion / Q000502:physiology; D006501:Hepatic Encephalopathy / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D011594:Psychometrics; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric