Anticonvulsant activity of embelin isolated from Embelia ribes.
Anticonvulsant activity of embelin (2.5, 5 and 10mg/kg, i.p.) was studied. It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole in a dose dependent manner and the activity was comparable to phenytoin and diazepam. Significant decrease in locomotion revealing its CNS depressant activity was observed. The findings suggest that embelin possess anticonvulsant activity against both grand mal and petit mal epilepsy.
Mahendran
S
S
J.S.S. College of Pharmacy, Ootacamund 643 001, TN, India.
Thippeswamy
B S
BS
Veerapur
V P
VP
Badami
S
S
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002492:Central Nervous System Depressants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D031645:Embelia / Q000737:chemistry*; D008124:Locomotion / Q000187:drug effects; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D016227:Benzoquinones; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D010672:Phenytoin; D003975:Diazepam; C010945:embelin; D010433:Pentylenetetrazole