title: Synthesis of sulfated pectins and their anticoagulant activity.
abstract: The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules.
authors.affiliation: Institute of Physiology, Komi Science Center, Syktyvkar, Russia.
authors.forename: F V
authors.initials: FV
authors.lastname: Vityazev
authors.forename: V V
authors.initials: VV
authors.lastname: Golovchenko
authors.forename: O A
authors.initials: OA
authors.lastname: Patova
authors.forename: N N
authors.initials: NN
authors.lastname: Drozd
authors.forename: V A
authors.initials: VA
authors.lastname: Makarov
authors.forename: A S
authors.initials: AS
authors.lastname: Shashkov
authors.forename: Yu S
authors.initials: YS
authors.lastname: Ovodov
mesh_terms: D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010368:Pectins / Q000138:chemical synthesis / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013451:Sulfonic Acids / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry*
chemical_list: D000925:Anticoagulants; D013451:Sulfonic Acids; C508701:bergenan BC; C423783:lemnan; C013880:chlorosulfonic acid; D013455:Sulfur; D010368:Pectins; C003181:polygalacturonic acid