title: Preventive and therapeutic potential of placental extract in contact hypersensitivity.
abstract: Immunoregulatory effects of placental extract and placenta-derived factors have been demonstrated in various conditions. Accordingly, placental extract has been used as certain types of medical intervention in Asian countries, whereas experimental evidence supporting its therapeutic effects and mechanisms has yet to be fully demonstrated. In this study, we investigate preventive and therapeutic effects of placental extract in contact hypersensitivity (CHS), a mouse model of allergic contact dermatitis. Administration of placental extract prior to the sensitization of allergic antigen (Ag) significantly inhibited the severity of CHS induced by Ag challenge. This effect was associated with reduced numbers of CD4(+) T cells in peripheral blood, decrease of tissue-infiltrating lymphocytes, and preferential production of Th2-type cytokines in Ag-challenged sites. In addition, CHS caused by repetitive challenges of allergic Ag was also prevented and treated by administration of placental extract. Finally, administration of cyclo-trans-4-L-hydroxyprolyl-L-serine, a dipeptide derived from placental extract, also alleviated CHS, suggesting its potential role in the effects of placental extract in CHS. Taken together, our findings demonstrated experimental evidence supporting immunoregulatory effects of placental extract in allergic skin diseases and elucidated its potential mechanisms.
authors.affiliation: Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Youn Son
authors.initials: YS
authors.lastname: Kim
authors.forename: Jang-June
authors.initials: JJ
authors.lastname: Park
authors.forename: Yukimi
authors.initials: Y
authors.lastname: Sakoda
authors.forename: Yuming
authors.initials: Y
authors.lastname: Zhao
authors.forename: Katsuya
authors.initials: K
authors.lastname: Hisamichi
authors.forename: Tai-Ichi
authors.initials: T
authors.lastname: Kaku
authors.forename: Koji
authors.initials: K
authors.lastname: Tamada
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004139:Dinitrofluorobenzene / Q000633:toxicity; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010920:Placenta; D011247:Pregnancy; D013154:Spleen / Q000378:metabolism; D019737:Transplants
chemical_list: D004139:Dinitrofluorobenzene