Swine as the possible source of hepatitis E virus transmission to humans in Thailand.
This report describes a study that provides evidence of HEV transmission from pigs to humans in Thailand by applying molecular genetics analysis. It was found that viruses recovered from Thai patients are closely related to genotype 3 and swine hepatitis E virus in Thailand. Based on analysis of a 302-base-pair ORF2 fragment, the strains investigated belong to subgroup 3e and are closely related to European strains. Based on the results obtained, swine are suspected to be a source of HEV transmission to humans in Thailand.
Suwannakarn
Kamol
K
Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, Thailand.
Tongmee
Chitima
C
Theamboonlers
Apiradee
A
Komolmit
Piyawat
P
Poovorawan
Yong
Y
D000818:Animals; D016000:Cluster Analysis; D005838:Genotype; D016751:Hepatitis E / Q000635:transmission* / Q000662:veterinary*; D016752:Hepatitis E virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013552:Swine / Q000821:virology*; D013553:Swine Diseases / Q000635:transmission* / Q000821:virology; D013785:Thailand; D014764:Viral Proteins / Q000235:genetics; D015047:Zoonoses / Q000635:transmission* / Q000821:virology
C400971:ORF2 protein, Hepatitis E virus; D012367:RNA, Viral; D014764:Viral Proteins