title: A single-institution experience with 491 cases of small bowel adenocarcinoma.
abstract: BACKGROUND
  The optimal treatment of small bowel adenocarcinoma is unknown.
  
  
  METHODS
  The records of 491 patients with small bowel adenocarcinoma diagnosis between 1970 and 2005 were reviewed for patient and tumor characteristics, treatment effects, and survival.
  
  
  RESULTS
  The median age at diagnosis was 62 years. The most common tumor locations were the duodenum (57%), jejunum (29%), and ileum (10%). The median overall survival was 20.1 months, with a 5-year overall survival of 26%. Greater age, male sex, higher stage and grade, residual disease after resection, and a lymph node ratio of 50% or greater predicted decreased overall survival in univariate analysis. Age and stage were predictive of survival in multivariate analysis. The overall survival with metastatic disease was poor. Adjuvant therapy was not associated with longer overall survival (P = .44).
  
  
  CONCLUSIONS
  The prognosis of patients with small bowel adenocarcinoma is poor. Complete resection provides the only means of cure, and the role for adjuvant therapy remains uncertain.
authors.affiliation: Department of Oncology, Mayo Clinic, Rochester, MN, USA. thorvardur-halfdanarson@uiowa.edu
authors.forename: Thorvardur R
authors.initials: TR
authors.lastname: Halfdanarson
authors.forename: Robert R
authors.initials: RR
authors.lastname: McWilliams
authors.forename: John H
authors.initials: JH
authors.lastname: Donohue
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Quevedo
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000601:surgery*; D007421:Intestine, Small; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome