title: Distribution of PCB 118 and PCB 153 and hydroxylated PCB metabolites (OH-CBs) in maternal, fetal and lamb tissues of sheep exposed during gestation and lactation.
abstract: The main objective of the present study was to gain knowledge about the disposition of the PCB congeners 118 and 153 in a sheep model where ewes were given oral doses of PCB in two consecutive gestations. The study aimed to investigate how maternal exposure with PCBs affected tissue concentrations in lambs and fetuses and to carry out time trend studies in ewes between gestations, as well as to increase the knowledge on metabolic processes by studying OH-metabolites. The results showed that the fetuses accumulated PCBs in levels and composition comparable to the ewes. The mean fetus/mother ratios of adipose tissue levels ranged from 0.71 to 0.82 for both PCB 118 and PCB 153 in the two exposure groups. Furthermore, the fetal brain/fat ratios ranged from 0.15 to 0.20 for both congeners. Body burden calculations (BB) showed that 16% and 43% of the total PCB 118 and PCB 153, respectively, still remained in ewes, lambs and fetuses after exposure during two gestations. The different accumulation of the two congeners is assumed to be a result of differences in metabolism. The present study demonstrate that high levels of PCB 118 and PCB 153 cross the placenta and accumulate in the fetal adipose tissue and brain thus exposing the fetus during vulnerable periods of extensive development.
authors.affiliation: Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, POB 8146 Dep., N-0033 Oslo, Norway. vidar.berg@nvh.no
authors.forename: Vidar
authors.initials: V
authors.lastname: Berg
authors.forename: Jan L
authors.initials: JL
authors.lastname: Lyche
authors.forename: Arno C
authors.initials: AC
authors.lastname: Gutleb
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Lie
authors.forename: Janneche Utne
authors.initials: JU
authors.lastname: Skaare
authors.forename: Mona
authors.initials: M
authors.lastname: Aleksandersen
authors.forename: Erik
authors.initials: E
authors.lastname: Ropstad
mesh_terms: D000818:Animals; D004785:Environmental Pollutants / Q000032:analysis / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006900:Hydroxylation; D007774:Lactation; D018811:Maternal Exposure; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000378:metabolism*; D011247:Pregnancy; D012756:Sheep / Q000378:metabolism*
chemical_list: D004785:Environmental Pollutants; C070055:2,3',4,4',5-pentachlorobiphenyl; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl