title: Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition.
abstract: The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia.
authors.affiliation: Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. krasimira.aleksandrova@dife.de
authors.forename: Krasimira
authors.initials: K
authors.lastname: Aleksandrova
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Eugene
authors.initials: E
authors.lastname: Jansen
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Christina C
authors.initials: CC
authors.lastname: Dahm
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Sophie
authors.initials: S
authors.lastname: Morois
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Fränzel J B
authors.initials: FJ
authors.lastname: van Duijnhoven
authors.forename: Anke M
authors.initials: AM
authors.lastname: Leufkens
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Catalina
authors.initials: C
authors.lastname: Bonet
authors.forename: María-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: Richard
authors.initials: R
authors.lastname: Palmqvist
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wareham
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Spencer
authors.forename: Dora
authors.initials: D
authors.lastname: Romaguera
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood / Q000453:epidemiology*; D005060:Europe; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin