title: Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease.
abstract: Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is reported to be an effective and safe treatment for superficial non-melanoma skin cancers. We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). Three patients diagnosed with BD by skin biopsy were recruited in this study. They received IPL treatment after 3 h of occlusive dressing with application of ALA. This protocol was repeated every 2 weeks for a total of five sessions. The treated areas did not show any signs of BD for more than 1 year; therefore, it appeared that the affected areas showed improvement in all the patients. No patients withdrew from the study because of side-effects. ALA-PDT with IPL as a light source is well tolerated by patients and is beneficial for treating BD.
authors.affiliation: Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan. t-hase@juntendo.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suga
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Kunitaka
authors.initials: K
authors.lastname: Haruna
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid