title: Human kallikrein 8 expression in salivary gland tumors.
abstract: The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum. It has also been shown to be a biomarker and prognostic factor for breast cancer. The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.
authors.affiliation: Division of Oral Pathology, Department of Pathology, University of Western Ontario, 1151 Richmond Street, London, Ontario, Canada. mark.darling@schulich.uwo.ca
authors.forename: Mark R
authors.initials: MR
authors.lastname: Darling
authors.forename: Sam
authors.initials: S
authors.lastname: Tsai
authors.forename: Linda
authors.initials: L
authors.lastname: Jackson-Boeters
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Daley
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Diamandis
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D018267:Carcinoma, Acinar Cell / Q000378:metabolism / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007610:Kallikreins / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012470:Salivary Glands, Minor / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C094799:KLK8 protein, human; D007610:Kallikreins