title: Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68.
abstract: Canine mammary carcinoma is a highly metastatic tumor that is poorly responsive to available treatment. Therefore, there is an urgent need to identify novel agents for therapy of this disease. Recently, we reported that the oncolytic vaccinia virus GLV-1h68 could be a useful tool for therapy of canine mammary adenoma in vivo. In this study we analyzed the therapeutic effect of GLV-1h68 against canine mammary carcinoma. Cell culture data demonstrated that GLV-1h68 efficiently infected and destroyed cells of the mammary carcinoma cell line MTH52c. Furthermore, after systemic administration, this attenuated vaccinia virus strain primarily replicated in canine tumor xenografts in nude mice. Finally, infection with GLV-1h68 led to strong inflammatory and oncolytic effects resulting in significant growth inhibition of the tumors. In summary, the data showed that the GLV-1h68 virus strain has promising potential for effective treatment of canine mammary carcinoma.
authors.affiliation: Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA.
authors.forename: Ivaylo
authors.initials: I
authors.lastname: Gentschev
authors.forename: Klaas
authors.initials: K
authors.lastname: Ehrig
authors.forename: Ulrike
authors.initials: U
authors.lastname: Donat
authors.forename: Michael
authors.initials: M
authors.lastname: Hess
authors.forename: Stephan
authors.initials: S
authors.lastname: Rudolph
authors.forename: Nanhai
authors.initials: N
authors.lastname: Chen
authors.forename: Yong A
authors.initials: YA
authors.lastname: Yu
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jörn
authors.initials: J
authors.lastname: Bullerdiek
authors.forename: Ingo
authors.initials: I
authors.lastname: Nolte
authors.forename: Jochen
authors.initials: J
authors.lastname: Stritzker
authors.forename: Aladar A
authors.initials: AA
authors.lastname: Szalay