title: Endoscopic resection of "giant" colorectal lesions: long-term outcome and safety.
abstract: BACKGROUND
  Today, endoscopic resection is a standard procedure for the resection of colonic polyps. Before the establishment of endoscopic techniques, the surgical approach was a clearly preferred method for removal of polyps with a size larger than three centimeters. The safety and effectiveness concerning endoscopic resections of colorectal polyps also with a size of more than 3 cm have been demonstrated in numerous studies.
  
  
  METHODS
  Data from 165 patients (age: 68 +/- 10.4 years) harboring 167 polyps with a minimum diameter of 3 cm were retrospectively evaluated. Objects of interest were macroscopic morphology and histopathology of the polyps, their localization in the colon, the modality of endoscopic resection and follow-up. In those cases with macroscopic signs of malignancy the patients were excluded.
  
  
  RESULTS
  Successful endoscopic resections were obtained in 72.5 %. Therefrom, resection in the piecemeal-technique was necessary in 73.6 %. Recurrence polyps after endoscopic complete resections occurred in 26.3 % after a mean follow-up of 16 +/- 12.5 months. We registered a complication rate of 19.2 %. Relevant bleeding and perforation were registered as early complications in 18.6 %. We observed no intervention-related mortality.
  
  
  CONCLUSIONS
  Endoscopic mucosal resection is a safe and efficient method even for removing giant colorectal polyps. Controls are recommended at defined intervals for detecting polyp recurrence.
authors.affiliation: Medical Department C, Klinikum Ludwigshafen Ludwigshafen, Germany. rico.hochdoerffer@gmx.de
authors.forename: R
authors.initials: R
authors.lastname: Hochdörffer
authors.forename: A
authors.initials: A
authors.lastname: Eickhoff
authors.forename: D
authors.initials: D
authors.lastname: Apel
authors.forename: J C
authors.initials: JC
authors.lastname: Eickhoff
authors.forename: D
authors.initials: D
authors.lastname: Hartmann
authors.forename: R
authors.initials: R
authors.lastname: Jakobs
authors.forename: J F
authors.initials: JF
authors.lastname: Riemann
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000517:prevention & control*; D016896:Treatment Outcome