The structure of the hypothetical protein smu.1377c from Streptococcus mutans suggests a role in tRNA modification.
Members of the Sua5_YciO_YrdC protein family are found in both eukaryotes and prokaryotes and possess a conserved alpha/beta twisted open-sheet fold. The Escherichia coli protein YrdC has been shown to be involved in modification of tRNA. The crystal structure of smu.1377c, a hypothetical protein from Streptococcus mutans, has been determined to 2.25 A resolution. From structure analysis and comparison, it is shown that smu.1377c is a member of the Sua5_YciO_YrdC family and that it may play the same role as E. coli YrdC.
Fu
Tian Min
TM
The National Laboratory of Protein Engineering and Plant Genetic Engineering, School of Life Sciences, Peking University, Beijing 100871, People's Republic of China.
Liu
Xiang
X
Li
Lanfen
L
Su
Xiao Dong
XD
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D017124:Conserved Sequence; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012343:RNA, Transfer / Q000737:chemistry* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D016415:Sequence Alignment; D013295:Streptococcus mutans / Q000737:chemistry* / Q000378:metabolism
D001426:Bacterial Proteins; D016601:RNA-Binding Proteins; D012343:RNA, Transfer