title: Mannose-binding lectin genotypes and susceptibility to epstein-barr virus infection in infancy.
abstract: In a cohort study of children < 4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient children, indicating that MBL may be involved in primary EBV infection in infancy.
authors.affiliation: Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen S, Denmark.
authors.forename: Jeppe T
authors.initials: JT
authors.lastname: Friborg
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Jarrett
authors.forename: Anders
authors.initials: A
authors.lastname: Koch
authors.forename: Peter
authors.initials: P
authors.lastname: Garred
authors.forename: June M L
authors.initials: JM
authors.lastname: Freeland
authors.forename: Andreas
authors.initials: A
authors.lastname: Andersen
authors.forename: Mads
authors.initials: M
authors.lastname: Melbye
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D020031:Epstein-Barr Virus Infections / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005838:Genotype; D006116:Greenland; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D008297:Male; D037601:Mannose-Binding Lectin / Q000172:deficiency* / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin