title: Enhancement factor in low-coherence enhanced backscattering and its applications for characterizing experimental skin carcinogenesis.
abstract: We experimentally study potential mechanisms by which the enhancement factor in low-coherence enhanced backscattering (LEBS) can probe subtle variations in radial intensity distribution in weakly scattering media. We use enhanced backscattering of light by implementing either (1) low spatial coherence illumination or (2) multiple spatially independent detections using a microlens array under spatially coherent illumination. We show that the enhancement factor in these configurations is a measure of the integrated intensity within the localized coherence or detection area, which can exhibit strong dependence on small perturbations in scattering properties. To further evaluate the utility of the LEBS enhancement factor, we use a well-established animal model of cutaneous two-stage chemical carcinogenesis. In this pilot study, we demonstrate that the LEBS enhancement factor can be substantially altered at a stage of preneoplasia. Our animal result supports the idea that early carcinogenesis can cause subtle alterations in the scattering properties that can be captured by the LEBS enhancement factor. Thus, the LEBS enhancement factor has the potential as an easily measurable biomarker in skin carcinogenesis.
authors.affiliation: Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907, USA.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Zhengbin
authors.initials: Z
authors.lastname: Xu
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Song
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Konger
authors.forename: Young L
authors.initials: YL
authors.lastname: Kim
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000737:chemistry; D002273:Carcinogens / Q000633:toxicity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D004817:Epidermis / Q000737:chemistry; D005260:Female; D008027:Light; D051379:Mice; D019047:Phantoms, Imaging; D010865:Pilot Projects; D012542:Scattering, Radiation; D012878:Skin Neoplasms / Q000139:chemically induced / Q000737:chemistry*
chemical_list: D014408:Biomarkers, Tumor; D002273:Carcinogens