title: Isolated delusional syndrome in Parkinson's Disease.
abstract: Psychotic features in patients with Parkinson's Disease usually present as visual hallucinations against a background of cognitive deterioration and dopaminomimetic therapy. Isolated delusions are rare. We report here 4 patients with Parkinson's Disease who developed a delusional syndrome resembling schizophreniform psychosis in the absence of changes in alertness, visual hallucinations or dementia. We suggest that this syndrome may be more common than previously recognized, and that it may be related to the use of dopaminergic medications and environmental triggers on a background of a susceptible individual. This syndrome suggests interesting parallels with the pathophysiology of amphetamine-induced psychosis and schizophrenia.
authors.affiliation: First Dept. of Psychiatry, Univ. of Athens Medical School, Greece.
authors.forename: Nikos
authors.initials: N
authors.lastname: Stefanis
authors.forename: Maria
authors.initials: M
authors.lastname: Bozi
authors.forename: Christos
authors.initials: C
authors.lastname: Christodoulou
authors.forename: Athanassios
authors.initials: A
authors.lastname: Douzenis
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Gasparinatos
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Stamboulis
authors.forename: Costas
authors.initials: C
authors.lastname: Stefanis
authors.forename: Leonidas
authors.initials: L
authors.lastname: Stefanis
mesh_terms: D000368:Aged; D000547:Amantadine / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001545:Benserazide / Q000627:therapeutic use; D052160:Benzothiazoles / Q000627:therapeutic use; D002396:Catechols / Q000627:therapeutic use; D002998:Clonazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D007211:Indoles / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D000077487:Pramipexole; D012563:Schizophrenia, Paranoid / Q000209:etiology*; D013577:Syndrome
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D002396:Catechols; D007189:Indans; D007211:Indoles; D009570:Nitriles; C031967:rasagiline; C046649:ropinirole; D007980:Levodopa; C071192:entacapone; D002998:Clonazepam; D001545:Benserazide; D000077487:Pramipexole; D000547:Amantadine