The diuretic bumetanide decreases autistic behaviour in five infants treated during 3 months with no side effects.
The inhibitory transmitter GABA has been suggested to play an important role in infantile autistic syndrome (IAS), and extensive investigations suggest that excitatory actions of GABA in neurological disorders are because of a persistent increase of [Cl(-) ](I) .


OBJECTIVE
To test the effects of the chloride co-transporter NKCC1 diuretic compound Bumetanide that reduces [Cl(-) ](I) on IAS.


METHODS
Bumetanide was administered daily (1mg daily) during a 3-month period and clinical and biological tests made. We used 5 standard IAS severity tests - Childhood Autism Rating Scale, Aberrant Behaviour Checklist, Clinical Global Impressions; Repetitive and Restrictive Behaviour and the Regulation Disorder Evaluation Grid.


RESULTS
We report a significant improvement in IAS with no side effects.


CONCLUSIONS
Bumetanide decreases autistic behaviour with no side effects suggesting that diuretic agents may exert beneficial effects on IAS and that alterations of the actions of GABA may be efficient in IAS treatment calling for large scale randomized trials.
Lemonnier
Eric
E
Centre de Resssources autisme de Bretagne, CHRU Brest Hopital Bohars, Bohars, France. Eric.lemonnier@chu-brest.fr
Ben-Ari
Yehezkel
Y
D001321:Autistic Disorder / Q000188:drug therapy*; D002034:Bumetanide / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000378:metabolism; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D028021:Sodium-Potassium-Chloride Symporters; D064506:Solute Carrier Family 12, Member 2; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D002712:Chlorides; D004232:Diuretics; C578877:SLC12A2 protein, human; D028021:Sodium-Potassium-Chloride Symporters; D064506:Solute Carrier Family 12, Member 2; D002034:Bumetanide; D005680:gamma-Aminobutyric Acid