[Influence of age on characteristics of cutaneous vasculitis: a series of 132 patients].
OBJECTIVE
Age onset of cutaneous vasculitis may influence clinical manifestations and outcome of this condition. However, to date, no authors have analyzed characteristics of cutaneous vasculitis, especially causes, in elderly patients (≥ 65 years).


METHODS
The aims of this retrospective study were to compare clinical and biochemical characteristics as well as causes of cutaneous vasculitis between elderly patients (n=58) and younger subjects (n=74).


RESULTS
Median time onset between first clinical symptoms and diagnosis of cutaneous vasculitis was similar between elderly and younger (15 vs 10 days; P=0.39). Clinical characteristics did not differ between the 2 groups. The following biochemical parameters were more frequently found in elderly patients: higher median levels of erythrocyte sedimentation rate (44 vs 28 mm/h; P=0.006), urea (8 vs 5 mmol/L; P<0.0001), creatininemia (92 vs 74 μmol/L; P=0.004), and lower values of serum protein (P=0.023). The more common causes of cutaneous vasculitis in elderly patients were as follows: infections (n=24), drugs (n=12), systemic vasculitides (n=8) and cancer (n=8); only cancer-associated cutaneous vasculitis was more frequently observed in elderly patients (P=0.02).


CONCLUSIONS
Our study suggests that age onset of cutaneous vasculitis may influence causes of cutaneous vasculitis, as cancer were more common in elderly patients. Moreover, infectious manifestations were different in elderly patients (urinary and pulmonary infections) compared to younger patients (otorhinolaryngeal infections). In essence, our data underline that the search for cancer should be performed in elderly patients exhibiting cutaneous vasculitis.
Marie
Isabelle
I
CHU de Rouen, Département de médecine interne, 76031 Rouen cedex, France. isabelle.marie@chu-rouen.fr
Mikolajcz
Stéphane
S
Benichou
Jacques
J
Grassi
Vanessa
V
Levesque
Hervé
H
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis / Q000209:etiology; D055815:Young Adult