title: Acquired reactive perforating collagenosis: current status.
abstract: Acquired reactive perforating collagenosis is a unique perforating dermatosis, characterized clinically by umbilicated hyperkeratotic papules or nodules and histologically by a focal hyperkeratosis in direct contact with transepidermal perforating dermal collagen. Several inflammatory or malignant systemic diseases may coexist with acquired reactive perforating collagenosis. The possible biochemical or immunological mechanisms of the systemic diseases, potentially responsible for the development and appearance of acquired reactive perforating collagenosis, are still under investigation. Several topical treatments, ultraviolet B phototherapy and allopurinol p.o. administration may be effective.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. karpouzis@bitservices.gr
authors.forename: Anthony
authors.initials: A
authors.lastname: Karpouzis
authors.forename: Alexandra
authors.initials: A
authors.lastname: Giatromanolaki
authors.forename: Efthimios
authors.initials: E
authors.lastname: Sivridis
authors.forename: Constantin
authors.initials: C
authors.lastname: Kouskoukis
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D003095:Collagen Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D014467:Ultraviolet Therapy
chemical_list: D000493:Allopurinol; D003094:Collagen