[Drug delivery of CPC/amifostine/cisplatin complex in vitro and its ability in repairing bone defect and eliminating tumor in vivo].
OBJECTIVE
To investigate the feasibility of using calcium phosphate cement/amifostine/cisplatin complex to fill and repair bone defect, caused by tumor resection.


METHODS
Drug concentration in the CPC/ amifostine/cisplatin complex was determined. Rabbits with bone defect and rats with osteosarcoma were implanted with CPC and CPC/amifostine/cisplatin complex.


RESULTS
Similar bone growth was observed in the femurs of rabbits implanted with CPC/amifostine/cisplatin complex and those implanted with CPC. CPC/amifostine/cisplatin complex delivered amifostine and cisplatin consistently and eliminated osteosarcoma cells implanted in the rats.


CONCLUSIONS
CPC/amifostine/cisplatin complex repairs bone defect caused by tumors as a filling material.
Liu
Yan-Ning
YN
Department of Orthopaedics, the First Affiliated Hospital, Medical Shool of Xi'an Jiaotong University, Xi'an 710061, China.
Liu
Miao
M
Ren
Peng-Yu
PY
D004999:Amifostine / Q000008:administration & dosage*; D000818:Animals; D001843:Bone Cements; D001859:Bone Neoplasms / Q000601:surgery; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005260:Female; D005269:Femur / Q000601:surgery*; D020007:Implants, Experimental; D008297:Male; D012516:Osteosarcoma / Q000601:surgery*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate; D004999:Amifostine; D002945:Cisplatin