Central mucoepidermoid carcinoma, a case report with molecular analysis of the TORC1/MAML2 gene fusion.
Mucoepidermoid carcinoma is the most common salivary gland malignancy. The majorities of these tumors arise in the parotid and minor salivary glands, but may rarely develop intraosseously. The latter is not uncommonly associated with diagnostic and management difficulties. We report an example of intraosseous mucoepidermoid carcinoma with positive TORC1/MAML2 gene fusion transcript and discuss the clinical implications.
Khan
Haseeb Ahmed
HA
Department of Pathology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Johar Town, Lahore, Pakistan. haseeb.a.khan@hotmail.com
Loya
Asif
A
Azhar
Rafay
R
Din
Nasir Ud
NU
Bell
Diana
D
D018277:Carcinoma, Mucoepidermoid / Q000000981:diagnostic imaging / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D050939:Gene Fusion; D006801:Humans; D007573:Jaw Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
C500984:CRTC1 protein, human; D004268:DNA-Binding Proteins; C471297:MAML2 protein, human; D009687:Nuclear Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors