title: Tissue saturation measurement--exciting prospects, but standardisation and reference data still needed.
abstract: Sepsis and shock result in disturbances in microcirculatory perfusion and tissue oxygen utilisation that may not be reflected in global measures of haemodynamics. Near-infrared spectroscopy enables measurement of tissue oxygen saturation (StO2) and provides information on local microvascular and mitochondrial function. This measure could be incorporated with existing targets of goal-directed therapy to provide an integrated approach to haemodynamic resuscitation of both the macro- and microcirculation in various shock states. However, key methodological factors must be addressed before widespread clinical application.
authors.affiliation: Department of Critical Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK. nljones@doctors.org.uk
authors.forename: Nicola
authors.initials: N
authors.lastname: Jones
authors.forename: Marius
authors.initials: M
authors.lastname: Terblanche
mesh_terms: D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units; D008833:Microcirculation / Q000276:immunology; D018482:Muscle, Skeletal / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology; D012772:Shock, Septic / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen