title: Prevalence of type 2 diabetes in Algerian patients with hepatitis C virus infection.
abstract: OBJECTIVE
  To investigate the prevalence of, and risk factors for, diabetes mellitus (DM) in Algerian patients with chronic hepatitis C virus (HCV) infection and in a control group.
  
  
  METHODS
  A cross-sectional study was undertaken. A total of 416 consecutive patients with viral chronic hepatitis attending the Internal Medicine Department of the University Hospital Center Touhami Benflis in Batna [290 HCV-infected and 126 hepatitis B virus (HBV)-infected patients] were prospectively recruited.
  
  
  RESULTS
  The prevalence of DM was higher in HCV-infected patients in comparison with HBV-infected patients (39.1% vs 5%, P < 0.0001). Among patients without cirrhosis, diabetes was more prevalent in HCV-infected patients than in HBV-infected patients (33.5% vs 4.3%, P < 0.0001). Among patients with cirrhosis, diabetes was more prevalent in HCV-infected patients, but the difference was not significant (67.4% vs 20%, P = 0.058). The logistic regression analysis showed that HCV infection [odds ratio (OR) 4.73, 95% CI: 1.7-13.2], metabolic syndrome (OR 12.35, 95% CI: 6.18-24.67), family history of diabetes (OR 3.2, 95% CI: 1.67-6.13) and increased hepatic enzymes (OR 2.22, 95% CI: 1.1-4.5) were independently related to DM in these patients.
  
  
  CONCLUSIONS
  The high prevalence of diabetes in HCV-infected patients, and its occurrence at early stages of hepatic disease, suggest that screening for glucose abnormalities should be indicated in these patients.
authors.affiliation: Department of Internal Medicine, University Hospital Center Touhami Benflis, Batna 05000, Algeria. rouabhiasamir@yahoo.fr
authors.forename: Samir
authors.initials: S
authors.lastname: Rouabhia
authors.forename: Rachid
authors.initials: R
authors.lastname: Malek
authors.forename: Hocine
authors.initials: H
authors.lastname: Bounecer
authors.forename: Aoulia
authors.initials: A
authors.lastname: Dekaken
authors.forename: Fouzia
authors.initials: F
authors.lastname: Bendali Amor
authors.forename: Mourad
authors.initials: M
authors.lastname: Sadelaoud
authors.forename: Abderrahmene
authors.initials: A
authors.lastname: Benouar
mesh_terms: D000328:Adult; D000462:Algeria / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology / Q000821:virology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors