Does the historical literature on encephalitis lethargica support a simple (direct) relationship with postencephalitic Parkinsonism?
This article and the subsequent one suggest that the currently accepted view of a simplistic (direct) relationship between encephalitis lethargica (EL) and postencephalitic Parkinsonism (PEP) is based on a incomplete evaluation of the epidemic period literature. In this article we provide a detailed analysis of the literature from the period that demonstrates that Parkinsonism was not initially part of acute EL symptomatology, that PEP was not typically the prevailing type of chronic EL and that oculogyric crises were never part of acute EL symptomatology and not initially associated with PEP. The second paper uses these finding, and also examines the clinical justifications for concluding that all patients with PEP had prior acute episodes of EL, to reevaluate the presumed direct etiologic relationship between EL and PEP.
Vilensky
Joel A
JA
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Fort Wayne, Indiana 46805, USA. vilensk@ipfw.edu
Gilman
Sid
S
McCall
Sherman
S
D004660:Encephalitis / Q000150:complications* / Q000266:history; D049673:History, 20th Century; D006801:Humans; D008513:Medicine in Literature; D010301:Parkinson Disease, Postencephalitic / Q000150:complications* / Q000266:history