title: How paraproteins can affect laboratory assays: spurious results and biological effects.
abstract: The presence of large amounts of monoclonal paraprotein in the serum can lead to a range of spurious laboratory results. These may result from analytical interference of the M-protein through chemical or immunological means, or from pre-analytical interference; the different modes of interference are explored in this review along with suggested methods of prevention or detection.
authors.affiliation: Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand. richard.king@cdhb.govt.nz
authors.forename: Richard I
authors.initials: RI
authors.lastname: King
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Florkowski
mesh_terms: D016477:Artifacts; D001774:Blood Chemical Analysis / Q000379:methods*; D003951:Diagnostic Errors; D006801:Humans; D010265:Paraproteinemias / Q000097:blood*; D010266:Paraproteins / Q000378:metabolism*
chemical_list: D010266:Paraproteins