Ischemia-modified albumin as an oxidative stress marker in preeclampsia.
OBJECTIVE
We examined serum ischaemia-modified albumin (IMA) levels in normal pregnant and preeclamptic women. The primary aim of our study was to assess IMA in women with mild and severe preeclampsia.


METHODS
Serum ischaemia-modified albumin levels were measured in 18 normotensive and 36 preeclamptic pregnant women by enzyme linked immuno-sorbent assay. Patients were subdivided as having either mild (n=18) or severe preeclampsia (n=18). Receiver operating characteristic curve was constructed, and sensitivity and specificity were calculated based on the best cut-off.


RESULTS
IMA levels were significantly higher in the mild and severe preeclamptic groups than in the control group. IMA with a cut-off point of 0.31 identified women with preeclampsia with sensitivity 80% and specificity 77.8%.


CONCLUSIONS
Our study demonstrates that serum levels of IMA correlate with severity of preeclampsia.
Ustün
Yusuf
Y
Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyus@yahoo.com
Engin-Ustün
Yaprak
Y
Oztürk
Ozlem
O
Alanbay
Ibrahim
I
Yaman
Halil
H
D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000150:complications; D018384:Oxidative Stress / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D011247:Pregnancy; D011499:Protein Processing, Post-Translational; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*; D012720:Severity of Illness Index; D055815:Young Adult
D015415:Biomarkers; D012709:Serum Albumin