Polymorphisms in the AR and PSA genes as markers of susceptibility and aggressiveness in prostate cancer.
The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06–2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21–2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.
Kuasne
Hellen
H
Department of General Biology, Biological Science Center, Londrina State University, Paraná, Brazil.
Rodrigues
Iara Sant'Ana
IS
Fuganti
Paulo Emílio
PE
Losi-Guembarovski
Roberta
R
Ito
Kazuhiro
K
Kishima
Marina O
MO
Rodrigues
Marco Aurélio de Freitas
MA
Rogatto
Silvia Regina
SR
Santos
Rodrigo Mattos dos
RM
Cólus
Ilce Mara de Syllos
IM
D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017430:Prostate-Specific Antigen / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018911:Trinucleotide Repeats / Q000235:genetics
D014408:Biomarkers, Tumor; D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen