title: Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay.
abstract: Hyperglycemia, secondary to the hypermetabolic stress response, is a common occurrence after thermal injury. This stress response has been documented to persist up to 9 months postburn. The purpose of this study was to measure insulin sensitivity in severely burned children before discharge when wounds are 95% healed. Twenty-four children, aged 4 to 17 years, with burns > or = 40% TBSA underwent a 2-hour oral glucose tolerance test before discharge from the acute pediatric burn unit. Plasma glucose and insulin levels as well as the Homeostasis Model Assessment for Insulin Resistance (HOMAIR) were compared with published oral glucose tolerance test data from healthy, nonburned children. There was a significant difference between severely burned children and nonburned, healthy children with respect to the HOMAIR. Severely burned children had a HOMAIR of 3.53 +/- 1.62 compared with the value in nonburned, healthy children of 1.28 +/- 0.16 (P < .05). Insulin resistance secondary to the hypermetabolic stress response persists in severely burned children when burn wounds are at least 95% healed. The results of this study warrant future investigations into therapeutic options for the burned child during the rehabilitative phase of their care after injury.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: Ricki Y
authors.initials: RY
authors.lastname: Fram
authors.forename: Melanie G
authors.initials: MG
authors.lastname: Cree
authors.forename: Robert R
authors.initials: RR
authors.lastname: Wolfe
authors.forename: David
authors.initials: D
authors.lastname: Barr
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002056:Burns / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D010351:Patient Discharge
chemical_list: D001786:Blood Glucose