title: Orbital swelling as a first symptom in breast carcinoma diagnosis: a case report.
abstract: BACKGROUND
  The frequency of intra-orbital metastasis in systemic cancer is a controversial topic. Of all metastatic tumors to the orbit of the eye, breast carcinoma is considered to be the most prevalent. Orbital findings typically present themselves after the diagnosis of the primary tumor, with an average delay of three to six years. In spite of that, this study reports a case in which orbital manifestation was the initial symptom in breast carcinoma diagnosis.
  
  
  METHODS
  A 66-year-old Italian Caucasian woman presented with a swelling located on the lower orbit of her right eye.
  
  
  CONCLUSIONS
  Previous cases report orbital manifestations discovered secondary to breast cancer. This case demonstrates that orbital symptoms may be the primary presentation of the disease. Orbital metastasis originating from breast cancer predicts widespread metastatic disease in other organs. In the presence of an ambiguous infiltrative orbital process, diagnostic examination of the breast is recommended.
authors.affiliation: Department of Surgery, Breast Unit, S, Martino Hospital, University of Genoa, Genoa, 16132 Italy. elisafrancone@gmail.com.
authors.forename: Elisa
authors.initials: E
authors.lastname: Francone
authors.forename: Federica
authors.initials: F
authors.lastname: Murelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Paroldi
authors.forename: Cecilia
authors.initials: C
authors.lastname: Margarino
authors.forename: Daniele
authors.initials: D
authors.lastname: Friedman