Two new amide alkaloids with anti-leukaemia activities from Aconitum taipeicum.
Two new amide alkaloids, named 3-isopropyl-tetrahydropyrrolo [1,2-a] pyrimidine-2,4(1H,3H)-dione (1) and 1-acetyl-2,3,6-triisopropyl-tetrahydropyrimidin-4(1H)-one (2), were isolated from the roots of Aconitum taipeicum. Their chemical structures were characterized on the basis of MS, 1D- and 2D NMR. The anti-leukaemia activities of the compounds were also tested. The results indicated that the compounds exhibited more significant cell growth inhibitory activities against HL-60 cells than adriamycin, with the IC(50) of 1.1 ± 0.03 μg/mL and 1.6 ± 0.07 μg/mL respectively. In addition, two compounds showed anti-tumor activities against K562 cells as well.
Xu
Ying
Y
Faculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, People's Republic of China.
Guo
Zeng Jun
ZJ
Wu
Nan
N
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D011744:Pyrimidinones / Q000737:chemistry* / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology*
C556861:1-acetyl-2,3,6-triisopropyl-tetrahydropyrimidin-4(1H)-one; C556860:3-isopropyl-tetrahydropyrrolo(1,2-a)pyrimidine-2,4(1H,3H)-dione; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D011744:Pyrimidinones; D011758:Pyrroles