Verisimilitude (or "truthlikeness") as an alternative to pro and cons: migraine and cluster headache mechanisms.
Calculating verisimilitude (or "truthlikeness") ad modum Popper is a quantitative alternative to the usual pros and cons in migraine and cluster headache mechanisms. The following items were evaluated: dilation of large cranial arteries during migraine; CGRP increase during migraine; migraine as a brain disorder; aura and migraine headache; brain stem activation during migraine; rCBF in migraine without aura; NO and pathophysiology of migraine; neurogenic inflammation and migraine; aura in cluster headache; and hypothalamic activation in cluster headache. It is concluded that verisimilitude calculations can be helpful when judging pathophysiological problems in migraine and cluster headache.
Tfelt-Hansen
Peer Carsten
PC
Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. ptha@glo.regionh.dk
D001933:Brain Stem / Q000503:physiopathology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology; D003027:Cluster Headache / Q000473:pathology / Q000503:physiopathology*; D004827:Epilepsy / Q000503:physiopathology; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008881:Migraine Disorders / Q000473:pathology / Q000503:physiopathology*; D014664:Vasodilation / Q000502:physiology
D015740:Calcitonin Gene-Related Peptide