title: NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies.
abstract: Metallo-ß-lactamases (MBL) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 ß-lactamase is the most commonly encountered MBL in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the ß-lactam, imipenem, in E. coli.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA.
authors.forename: Timo
authors.initials: T
authors.lastname: Weide
authors.forename: S Adrian
authors.initials: SA
authors.lastname: Saldanha
authors.forename: Dmitriy
authors.initials: D
authors.lastname: Minond
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Spicer
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Fotsing
authors.forename: Michael
authors.initials: M
authors.lastname: Spaargaren
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Frère
authors.forename: Carine
authors.initials: C
authors.lastname: Bebrone
authors.forename: K Barry
authors.initials: KB
authors.lastname: Sharpless
authors.forename: Peter S
authors.initials: PS
authors.lastname: Hodder
authors.forename: Valery V
authors.initials: VV
authors.lastname: Fokin