title: Prolonged coma in a child due to hashish ingestion with quantitation of THC metabolites in urine.
abstract: BACKGROUND
  Cannabinoid-containing substances are commonly abused worldwide. Significant toxicity from these substances is uncommon in adults but can result in significant symptoms in children; these symptoms are usually short-lived.
  
  
  OBJECTIVE
  To report a case of prolonged mental status alteration of more than 2 days in a child who ingested hashish.
  
  
  METHODS
  A 14-month-old child presented comatose to a pediatric emergency department after ingestion of hashish; she did not regain consciousness for more than 48 h. Quantitative testing of the child's urine for a tetrahydrocannabinol metabolite revealed a markedly elevated level, the decline of which coincided with the child's clinical improvement.
  
  
  CONCLUSIONS
  Significant ingestion of cannabinoid-containing substances is capable of causing prolonged symptoms (including coma) in children.
authors.affiliation: Department of Emergency Medicine, Division of Medical Toxicology, University of California San Diego, San Diego, California, USA.
authors.forename: Shaun D
authors.initials: SD
authors.lastname: Carstairs
authors.forename: Michael K
authors.initials: MK
authors.lastname: Fujinaka
authors.forename: Grant E
authors.initials: GE
authors.lastname: Keeney
authors.forename: Binh T
authors.initials: BT
authors.lastname: Ly
mesh_terms: D000284:Administration, Oral; D015415:Biomarkers / Q000652:urine; D002188:Cannabis / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced*; D013759:Dronabinol / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant
chemical_list: D015415:Biomarkers; D013759:Dronabinol