title: Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.
abstract: Three 1-methoxy analogs of CP-47,497 (7, 8, and 19) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although these compounds exhibit selectivity for the CB(2) receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of these compounds for either receptor.
authors.affiliation: Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634-0973, United States. huffman@clemson.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Huffman
authors.forename: Seon A
authors.initials: SA
authors.lastname: Hepburn
authors.forename: Patricia H
authors.initials: PH
authors.lastname: Reggio
authors.forename: Dow P
authors.initials: DP
authors.lastname: Hurst
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Wiley
authors.forename: Billy R
authors.initials: BR
authors.lastname: Martin
mesh_terms: D000818:Animals; D001665:Binding Sites; D016466:CHO Cells; D003198:Computer Simulation; D006224:Cricetinae; D003412:Cricetulus; D003511:Cyclohexanols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D003511:Cyclohexanols; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; C036088:CP 47497