title: Lessons from coronary intravascular ultrasound on the importance of raising high-density lipoprotein cholesterol.
abstract: Technological advances have enhanced our ability to visualize the entire extent of atherosclerosis within the artery wall. Intravascular ultrasound has enabled characterization of the impact of medical therapies on progression of coronary atherosclerosis. Despite use of established anti-atherosclerotic therapy, cardiovascular disease still remains the leading cause of morbidity and mortality. There is an ongoing need to develop new therapeutic strategies to achieve more effective reduction in cardiovascular risk. Raising high-density lipoprotein cholesterol continues to receive attention as a therapeutic strategy. The relationship between high-density lipoprotein and progression of atherosclerosis and its implications for clinical practice are reviewed here.
authors.affiliation: Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Mail Code JJ-65, 9500 Euclid Avenue, Cleveland, OH 44195, USA. nichols1@ccf.org
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Uno
authors.forename: E Murat
authors.initials: EM
authors.lastname: Tuzcu
authors.forename: Steven E
authors.initials: SE
authors.lastname: Nissen
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000000981:diagnostic imaging*; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D018450:Disease Progression; D006801:Humans; D015203:Reproducibility of Results; D012307:Risk Factors; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D008076:Cholesterol, HDL