title: Mitochondrial injury and protection in ischemic pre- and postconditioning.
abstract: Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of the mitochondrial permeability transition pore. The formation of reactive oxygen species in mitochondria will be analyzed with regard to factors controlling mitochondrial permeability transition pore opening. Finally, these mitochondrial processes are analyzed with respect to cardioprotection afforded by ischemic pre- and postconditioning.
authors.affiliation: Department of Biomedical Sciences, Università di Padova, Viale G. Colombo 3, Padua, Italy. dilisa@bio.unipd
authors.forename: Fabio
authors.initials: F
authors.lastname: Di Lisa
authors.forename: Marcella
authors.initials: M
authors.lastname: Canton
authors.forename: Andrea
authors.initials: A
authors.lastname: Carpi
authors.forename: Nina
authors.initials: N
authors.lastname: Kaludercic
authors.forename: Roberta
authors.initials: R
authors.lastname: Menabò
authors.forename: Sara
authors.initials: S
authors.lastname: Menazza
authors.forename: Martina
authors.initials: M
authors.lastname: Semenzato
mesh_terms: D000818:Animals; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology; D019157:Ischemic Preconditioning, Myocardial; D008929:Mitochondria, Heart / Q000378:metabolism / Q000473:pathology*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D017382:Reactive Oxygen Species