[Reversibility of hepatitis B virus-induced liver cirrhosis after prolonged antiviral therapy].
Reversibility of liver fibrosis or cirrhosis involves complete restoration of normal liver architecture. This phenomenon has been well documented in chronic liver diseases such as autoimmune hepatitis, biliary obstruction, hemochromatosis, nonalcoholic steatohepatitis, and viral hepatitis. There are very few reports of reversal of cirrhosis after antiviral therapy in patients with chronic hepatitis B virus (HBV) infection. We report a case of disappearance of HBV-induced liver cirrhosis after years of treatment with distinct antiviral drugs, documented by successive biopsy results. This disappearance was accompanied by normalization of platelet count, gammaglobulin titers, and radiologic findings.
Pérez Roldán
Francisco
F
Hospital General La Mancha-Centro, Alcázar de San Juan, España. perezrold@teleline.es
Vives Domínguez
Leopoldo
L
González Carro
Pedro
P
Villafáñez García
Maria Concepción
MC
Fernández Acenero
Maria Jesús
MJ
Cuesta Domínguez
Rubén
R
Aoufi Rabih
Sami
S
Ruíz Carrillo
Francisco
F
D000998:Antiviral Agents / Q000627:therapeutic use*; D006509:Hepatitis B / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors
D000998:Antiviral Agents