title: Familial pancreatic cancer in Italy. Risk assessment, screening programs and clinical approach: a position paper from the Italian Registry.
abstract: In Italy, pancreatic cancer is the fifth leading cause of tumor related death with about 7000 new cases per year and a mortality rate of 95%. In a recent prospective epidemiological study on the Italian population, a family history was found in about 10% of patients suffering from a ductal adenocarcinoma of the pancreas (PDAC). A position paper from the Italian Registry for Familial Pancreatic Cancer was made to manage these high-risk individuals. Even though in the majority of high-risk individuals a genetic test to identify familial predisposition is not available, a screening protocol seems to be reasonable for subjects who have a >10-fold greater risk for the development of PDAC. However this kind of screening should be included in clinical trials, performed in centers with high expertise in pancreatic disease, using the least aggressive diagnostic modalities.
authors.affiliation: Division of General and Transplant Surgery, Pisa University Hospital, Via Paradisa 2, 56124 Cisanello, Pisa, Italy. m.delchiaro@ao-pisa.toscana.it
authors.forename: Marco
authors.initials: M
authors.lastname: Del Chiaro
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zerbi
authors.forename: Gabriele
authors.initials: G
authors.lastname: Capurso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zamboni
authors.forename: Patrick
authors.initials: P
authors.lastname: Maisonneuve
authors.forename: Silvano
authors.initials: S
authors.lastname: Presciuttini
authors.forename: Paolo Giorgio
authors.initials: PG
authors.lastname: Arcidiacono
authors.forename: Lucia
authors.initials: L
authors.lastname: Calculli
authors.forename: Massimo
authors.initials: M
authors.lastname: Falconi
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000235:genetics; D019160:Endosonography; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D018810:Magnetic Resonance Angiography; D009386:Neoplastic Syndromes, Hereditary / Q000000981:diagnostic imaging* / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000235:genetics; D018579:Patient Selection; D011159:Population Surveillance / Q000379:methods*; D018570:Risk Assessment