Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.
BACKGROUND
The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial.


METHODS
This first case-control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion.


RESULTS
We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59-2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke (n = 42); odds ratio, 2.1; 95% CI: 1.17-3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86-23.1, P = 0.003, for TT genotype variant compared with CC wild genotype.


CONCLUSIONS
We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco.
They-They
T P
TP
Hassan II University, Ibn Rochd Hospital, District Hospitals, Casablanca, Morocco. thierrypal@yahoo.fr
Nadifi
S
S
Rafai
M A
MA
Battas
O
O
Slassi
I
I
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000145:classification / Q000235:genetics*
D042965:Methylenetetrahydrofolate Reductase (NADPH2)