title: Synthesis, DNA-binding and photocleavage of "light switch" complexes [Ru(bpy)2(pyip)]2+ and [Ru(phen)2(pyip)]2+.
abstract: Two novel Ru(II) complexes [Ru(bpy)(2)(pyip)](2+)1 and [Ru(phen)(2)(pyip)](2+)2 (bpy=2,2'-bipyridine; phen=1,10-phenanthroline; pyip=2-(pyridine-2-yl)imidazo-[4,5-f][1,10]-phenanthroline), have been synthesized and characterized by elemental analysis, ES-MS, (1)H NMR, UV-Vis. The DNA-binding behaviors of both complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the two complexes can bind to CT-DNA in an intercalative mode, and also show that these two Ru(II) complexes can promote the photocleavage of pBR322 DNA. In addition, In the presence of Co(2+), the emission of DNA-[Ru(L)(2)pyip](2+) can be quenched, which exhibited the DNA "light switch" properties.
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University of Arts and Science, ChangDe 415000, PR China. liuxuewen050@sina.com
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Liu
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Shen
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Lu
authors.forename: Yuan-Dao
authors.initials: YD
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Da-Shun
authors.initials: DS
authors.lastname: Zhang
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D007364:Intercalating Agents / Q000737:chemistry; D008027:Light; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry* / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007364:Intercalating Agents; D010618:Phenanthrolines; D012428:Ruthenium; D004247:DNA; C025205:1,10-phenanthroline