Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis.
To test the hypothesis that bacterial contamination of menstrual blood could be a local biologic event in the development of endometriosis, menstrual blood was cultured and bacterial endotoxin was measured in menstrual blood and peritoneal fluid. Our results suggest that compared with control women, higher colony formation of Escherichia coli in menstrual blood and endotoxin levels in menstrual fluid and peritoneal fluid in women with endometriosis may promote Toll-like receptor 4-mediated growth of endometriosis.
Khan
Khaleque Newaz
KN
Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. nemokhan@nagasaki-u.ac.jp
Kitajima
Michio
M
Hiraki
Koichi
K
Yamaguchi
Naohiro
N
Katamine
Shigeru
S
Matsuyama
Toshifumi
T
Nakashima
Masahiro
M
Fujishita
Akira
A
Ishimaru
Tadayuki
T
Masuzaki
Hideaki
H
D000293:Adolescent; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry / Q000382:microbiology / Q000473:pathology; D001769:Blood / Q000382:microbiology; D016022:Case-Control Studies; D002478:Cells, Cultured; D015169:Colony Count, Microbial; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D004715:Endometriosis / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004731:Endotoxins / Q000097:blood / Q000633:toxicity*; D004927:Escherichia coli Infections / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008598:Menstruation / Q000097:blood*; D010532:Peritoneal Diseases / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D055815:Young Adult
D016207:Cytokines; D004731:Endotoxins; C044101:endotoxin, Escherichia coli