title: Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.
abstract: N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Università 'La Sapienza', P.le A. Moro 5, 00185 Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Chimenti
authors.forename: Bruna
authors.initials: B
authors.lastname: Bizzarri
authors.forename: Adriana
authors.initials: A
authors.lastname: Bolasco
authors.forename: Daniela
authors.initials: D
authors.lastname: Secci
authors.forename: Paola
authors.initials: P
authors.lastname: Chimenti
authors.forename: Arianna
authors.initials: A
authors.lastname: Granese
authors.forename: Simone
authors.initials: S
authors.lastname: Carradori
authors.forename: Daniela
authors.initials: D
authors.lastname: Rivanera
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zicari
authors.forename: M Maddalena
authors.initials: MM
authors.lastname: Scaltrito
authors.forename: Francesca
authors.initials: F
authors.lastname: Sisto
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D024881:Drug Resistance, Bacterial; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D003374:Coumarins; D016209:Interleukin-8; D008795:Metronidazole; C030123:coumarin