title: Design of artificial selenoenzymes based on macromolecular scaffolds.
abstract: The selenoenzyme glutathione peroxidase has received increased attention as one of the antioxidative enzymes exerting important biological roles in living bodies. Over the past decades, much effort has been invested to mimic its catalytic behavior for understanding enzymatic catalytic mechanisms and also for developing potential medicines. A great number of artificial GPxs, ranging from small molecular compounds to macromolecular ones, have been designed and prepared by combining the concept of recognition and catalysis using chemical, biological and supramolecular strategies. In this article, we specify the development of artificial GPxs based on macromolecules as scaffolds, and discuss the power of reduced models in studying the bio-catalytic nature of selenoenzymes.
authors.affiliation: State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Yanzhen
authors.initials: Y
authors.lastname: Yin
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D055162:Biocatalysis; D020134:Catalytic Domain; D005979:Glutathione Peroxidase / Q000138:chemical synthesis* / Q000737:chemistry*; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015202:Protein Engineering / Q000379:methods*
chemical_list: D008823:Micelles; D016566:Organoselenium Compounds; D005979:Glutathione Peroxidase