Multifunctional cytotoxic agents from Anacardium occidentale.
The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
Kubo
Isao
I
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3114, USA. ikubo@calmail.berkeley.edu
Nitoda
Teruhiko
T
Tocoli
Felismino E
FE
Green
Ivan R
IR
D048729:Anacardic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031021:Anacardium / Q000737:chemistry*; D000818:Animals; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis; D008544:Melanocytes / Q000187:drug effects*; D008545:Melanoma / Q000473:pathology; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D048729:Anacardic Acids; D003603:Cytotoxins; D008543:Melanins; D012118:Resorcinols; D014442:Monophenol Monooxygenase; C041328:adipostatin A