title: Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis.
abstract: Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results.
authors.affiliation: Department of Orthopaedic and Hand Surgery, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland. nina.c.lindfors@hus.fi
authors.forename: N C
authors.initials: NC
authors.lastname: Lindfors
authors.forename: P
authors.initials: P
authors.lastname: Hyvönen
authors.forename: M
authors.initials: M
authors.lastname: Nyyssönen
authors.forename: M
authors.initials: M
authors.lastname: Kirjavainen
authors.forename: J
authors.initials: J
authors.lastname: Kankare
authors.forename: E
authors.initials: E
authors.lastname: Gullichsen
authors.forename: J
authors.initials: J
authors.lastname: Salo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation; D005260:Female; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000502:physiology; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D011182:Postoperative Care; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000502:physiology; D013977:Tibia / Q000382:microbiology / Q000473:pathology
chemical_list: D018786:Bone Substitutes; C403922:bioactive glass S53P4