title: Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape.
abstract: Pathogenic yeasts, either from the environment or the normal flora, have to face phagocytic cells that constitute the first line of defence during infection. In order to evade or counteract attack by phagocytes, pathogenic yeasts have acquired a repertoire of strategies to survive, colonize and infect the host. In this review we focus on the interaction of yeasts, such as Candida, Histoplasma or Cryptococcus species, with macrophages or neutrophils. We discuss strategies used by these fungi to prevent phagocytosis or to counteract phagocytic activities. We go on to describe the strategies that permit intracellular survival within phagocytes and that may eventually lead to damage of and escape from the phagocyte.
authors.affiliation: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute Jena (HKI), Jena, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Seider
authors.forename: Antje
authors.initials: A
authors.lastname: Heyken
authors.forename: Anja
authors.initials: A
authors.lastname: Lüttich
authors.forename: Pedro
authors.initials: P
authors.lastname: Miramón
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hube
mesh_terms: D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009181:Mycoses / Q000276:immunology* / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology; D010586:Phagocytes / Q000276:immunology*; D010587:Phagocytosis; D015003:Yeasts / Q000276:immunology* / Q000472:pathogenicity