A new monoterpene acid from Marrubium vulgare with potential antihepatotoxic activity.
The whole plant of Marrubium vulgare L. afforded a new terpenoid, characterised as p-menthane-5,6-dihydroxy-3-carboxylic acid (1), which has been designated as marrubic acid. Its structure has been elucidated on the basis of spectral and chemical analyses. The compound (1) also exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 40.16%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 35.06%, and alkaline phosphatase (ALP) by 30.51%. On the other hand, total protein (TP) levels were increased by 34.07%, as compared to the standard drug silymarin, which decreased SGOT by 53.04%, SGPT by 55.96%, ALP by 35.87% and increased TP levels by 59.59%. These biochemical observations were also supplemented by histopathological examinations of liver sections.
Ahmed
Bahar
B
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India. drbahmed@rediffmail.com
Masoodi
Mubashir H
MH
Siddique
Anwarul H
AH
Khan
Shamshir
S
D000469:Alkaline Phosphatase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D024443:Aspartate Aminotransferase, Cytoplasmic / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D027522:Marrubium / Q000737:chemistry*; D015394:Molecular Structure; D039821:Monoterpenes / Q000032:analysis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology
D001798:Blood Proteins; D039821:Monoterpenes; D012838:Silymarin; D024443:Aspartate Aminotransferase, Cytoplasmic; D000469:Alkaline Phosphatase