Toxicogenomics using yeast DNA microarrays.
Development of genomics and bioinformatics enable us to analyze the global gene expression profiles of cells by DNA microarray. Changes in gene expression patterns indicate changes in its physiological conditions. Following the exposure of an organism or cell to toxic chemicals or other environmental stresses, the global genetic responses can be expeditiously and easily analyzed. Baker's yeast, Saccharomyces cerevisiae, is one of the most studied and useful model eukaryotes. The biggest advantage of yeast genomics is the available functional information for each gene and a considerable number of data are accumulating in the field of toxicity assessment using yeast DNA microarray. In this review, we discuss the toxicogenomics of metal ions, alcohols and aldehydes, and other chemicals.
Yasokawa
Daisuke
D
Hokkaido Food Processing Research Center, Department of Food Development, 589-4 Bunkyodai Midorimachi, Ebetsu, Hokkaido 0690836, Japan. yasokawa-daisuke@hro.or.jp
Iwahashi
Hitoshi
H
D000438:Alcohols / Q000633:toxicity; D000447:Aldehydes / Q000633:toxicity; D019295:Computational Biology; D020869:Gene Expression Profiling / Q000706:statistics & numerical data; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D005800:Genes, Fungal / Q000187:drug effects; D019216:Metals, Heavy / Q000633:toxicity; D020411:Oligonucleotide Array Sequence Analysis / Q000706:statistics & numerical data; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D043922:Toxicogenetics / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends
D000438:Alcohols; D000447:Aldehydes; D019216:Metals, Heavy