title: Treatment for mechanical valve thrombosis in the right heart: combined pharmacological and mechanical thrombolysis.
abstract: We report clinical results of combined pharmacological and mechanical thrombolysis for mechanical prosthetic valve thrombosis (PVT) in the right heart. Between January 1992 and December 2008, combined thrombolysis, which consisted of an intravenous infusion of urokinase together with mechanical disruption of thrombus in a prosthetic valve by temporarily increasing the cardiac pacing rate, was performed in three patients with four cases of mechanical PVT in the right heart. The prosthetic valve in all three patients was a bileaflet mechanical valve, and was located in the tricuspid position in two patients and in the pulmonary position in the remaining patient. PVT was diagnosed by echocardiography and cineradiography. Thrombolysis was successful in all four cases in the three patients, and no hemorrhagic complications or clinically symptomatic pulmonary embolisms were observed. Mechanical disruption of thrombus using a pacemaker appears to be an effective adjunctive modality to thrombolysis with fibrinolytic agents for PVT in the right heart. Combined pharmacological and mechanical thrombolysis may improve success rates and reduce the time required for thrombolysis of PVT.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Kurume, Japan. aoyagi@med.kurume-u.ac.jp
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Aoyagi
authors.forename: Shuji
authors.initials: S
authors.lastname: Fukunaga
authors.forename: Hideki
authors.initials: H
authors.lastname: Teshima
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006349:Heart Valve Diseases / Q000188:drug therapy / Q000209:etiology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011664:Pulmonary Valve; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D014261:Tricuspid Valve; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents