Isolation of virus-cell fusion inhibitory components from the stem bark of Styrax japonica S. et Z.
Five compounds, styraxjaponoside A (1), matairesinoside (2), egonol glucoside (3), dihydrodehydrodiconiferyl alcohol 9'-O-glucoside (4), and styraxjaponoside B (5) were isolated from the stem bark of Styrax japonica. Among them, compounds 1 and 5 showed significantly high virus-cell fusion inhibitory activity. In addition, compound 5 exhibited almost equivalent virus-cell fusion inhibitory activity to that of dextran sulfate, which is used as a positive control.
Lee
Dung Gun
DG
School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea.
Jin
Qinglong
Q
Jin
Hong-Guang
HG
Shin
Ji Eun
JE
Choi
Eun Jin
EJ
Woo
Eun-Rhan
ER
D000465:Algorithms; D015704:CD4 Antigens / Q000378:metabolism; D055808:Drug Discovery; D015726:Giant Cells / Q000187:drug effects / Q000821:virology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000378:metabolism; D023581:HIV Fusion Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006367:HeLa Cells; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008031:Lignin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D032362:Styrax / Q000737:chemistry*; D014616:Vaccinia virus / Q000235:genetics / Q000502:physiology
D015704:CD4 Antigens; D006027:Glycosides; D015699:HIV Envelope Protein gp120; D023581:HIV Fusion Inhibitors; D017705:Lignans; D010936:Plant Extracts; C499866:styraxjaponoside A; C499868:styraxjaponoside B; D008031:Lignin