Aberrant microRNA expression pattern in myelodysplastic bone marrow cells.
The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n=12) and distinct cytogenetic aberrations (n=12). In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), -7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells.
Hussein
Kais
K
Institute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. Hussein.Kais@MH-Hannover.de
Theophile
Katharina
K
Büsche
Guntram
G
Schlegelberger
Brigitte
B
Göhring
Gudrun
G
Kreipe
Hans
H
Bock
Oliver
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002872:Chromosome Deletion; D017931:DNA Primers; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007621:Karyotyping; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction
D017931:DNA Primers; D035683:MicroRNAs