Intravenous fat emulsion to reverse haemodynamic instability from intentional amitriptyline overdose.
We report the first case of amitriptyline toxicity treated with intravenous fat emulsion (IFE). Toxicity was manifested as vasopressor-refractory haemodynamic instability despite standard therapy. Our patient recovered with no adverse effects noted.
Engels
Paul T
PT
Division of Critical Care Medicine, University of Alberta, Canada. pengels@ualberta.ca
Davidow
Jonathan S
JS
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D062787:Drug Overdose / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006323:Heart Arrest / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male
D000929:Antidepressive Agents, Tricyclic; D005217:Fat Emulsions, Intravenous