[Benefit and pitfalls in the use of data from surrogate endpoint trials for clinical decision making].
Ideally clinicians should base their treatment decision on results from randomised controlled trials which include patient-important outcomes, such as quality of life, prevented disease events or death. Conducting such trials often involves large samples sizes and extended follow-up periods. Therefore, researchers have aimed to conduct trials with surrogate endpoints by substituting patient-important outcomes in order to reduce sample size and observation time. Surrogate endpoints are outcomes that substitute for direct measures of how a patient feels, functions, or survives. In many countries drugs are approved based on data from surrogate endpoint trials. Recently, a controversy has evolved on the reliability of results generated from surrogate endpoint trials driven by unanticipated side effects or severe toxicity leading to the withdrawal of drugs that were solely approved based on evidence from surrogate endpoint trials. We present some recent examples and criteria how clinicians can critically evaluate the validity of claims by experts or the pharmaceutical industry in regard to the expected patients' benefit from drugs approved by results from surrogate endpoint trials.
Bucher
Heiner C
HC
Basel Institute for Clinical Epidemiology & Biostatistics, Universitätsspital Basel. bucherh@uhbs.ch
D002986:Clinical Trials as Topic / Q000379:methods* / Q000592:standards; D003657:Decision Making; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy; D004358:Drug Therapy / Q000379:methods / Q000592:standards; D006801:Humans; D010361:Patients; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D016019:Survival Analysis; D017741:Survivors; D016896:Treatment Outcome