title: Visceral involvements and long-term sequelae in drug-induced hypersensitivity syndrome.
abstract: Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic reaction with several herpesvirus reactivations. Multiple organ failures appear during the course of the disease. The severity of DIHS is determined by the degree of visceral involvement. Autoimmune diseases also develop several months to years after the apparent clinical resolution of DIHS.
authors.affiliation: Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan. kano@ks.kyorin-u.ac.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kano
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Hirahara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shiohara
mesh_terms: D001327:Autoimmune Diseases / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced; D004066:Digestive System Diseases / Q000139:chemically induced* / Q000209:etiology; D004342:Drug Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D006331:Heart Diseases / Q000139:chemically induced; D006564:Herpesviridae / Q000502:physiology; D006566:Herpesviridae Infections / Q000139:chemically induced / Q000821:virology; D007674:Kidney Diseases / Q000139:chemically induced; D008171:Lung Diseases / Q000139:chemically induced; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced; D008590:Meningoencephalitis / Q000139:chemically induced; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000821:virology; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000139:chemically induced; D013577:Syndrome; D013966:Thyroiditis / Q000139:chemically induced; D013997:Time Factors; D014775:Virus Activation