Sestrins at the crossroad between stress and aging.
Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
Lee
Jun Hee
JH
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA.
Bodmer
Rolf
R
Bier
Ethan
E
Karin
Michael
M
D000375:Aging / Q000502:physiology*; D000818:Animals; D025461:Feedback, Physiological / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*
D006360:Heat-Shock Proteins; D009687:Nuclear Proteins