Nanoscopic porous sensors.
There are thousands of different nanometer-scale pores in biology, many of which act as sensors for specific chemical agents. Recent work suggests that protein and solid-state nanopores have many potential uses in a wide variety of analytical applications. In this review we survey this field of research and discuss the prospects for advances that could be made in the near future.
Kasianowicz
John J
JJ
National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8120, USA. john.kasianowicz@nist.gov
Robertson
Joseph W F
JW
Chan
Elaine R
ER
Reiner
Joseph E
JE
Stanford
Vincent M
VM
D000818:Animals; D001703:Biophysics / Q000379:methods*; D002623:Chemistry Techniques, Analytical; D004269:DNA, Bacterial / Q000378:metabolism; D005583:Fourier Analysis; D006801:Humans; D008390:Markov Chains; D008968:Molecular Conformation; D053761:Nanocomposites; D036103:Nanotechnology / Q000379:methods*; D016062:Porosity
D004269:DNA, Bacterial