title: Inhibitors of osteoclastogenesis from Lawsonia inermis leaves.
abstract: Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-kappaB ligand-induced osteoclast formation in murine bone-marrow macrophages.
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam.
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Nguyen Phuong
authors.initials: NP
authors.lastname: Thao
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nam
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Le Mai
authors.initials: le M
authors.lastname: Huong
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Ji-Hee
authors.initials: JH
authors.lastname: Won
authors.forename: Won-Yoon
authors.initials: WY
authors.lastname: Chung
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031564:Lawsonia Plant / Q000737:chemistry*; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D016328:NF-kappa B / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects*; D010666:Phenylpropionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D005960:Glucosides; D016328:NF-kappa B; D010666:Phenylpropionates; C553336:lawsoniaside A; C553337:lawsoniaside B; D010696:Phloroglucinol