Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment.
Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.(a).
Knaak
James B
JB
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA.
Dary
Curt C
CC
Okino
Miles S
MS
Power
Fred W
FW
Zhang
Xiaofei
X
Thompson
Carol B
CB
Tornero-Velez
R
R
Blancato
Jerry N
JN
D002219:Carbamates; D006801:Humans; D007306:Insecticides / Q000737:chemistry; D008954:Models, Biological; D010575:Pesticides; D021281:Quantitative Structure-Activity Relationship; D018570:Risk Assessment
D002219:Carbamates; D007306:Insecticides; D010575:Pesticides