title: Do local anesthetics have antibacterial effect on Staphylococcus aureus under in vivo conditions? An experimental study.
abstract: OBJECTIVE
  The antimicrobial properties against Staphylococcus aureus of some common local anesthetic preparations such as prilocaine, bupivacaine, articaine, and combinations were evaluated in a live rat surgical wound model.
  
  
  METHODS
  This study was conducted at the animal research laboratory of Eskisehir Osmangazi University in 2003. Clean surgical wounds were created after local anesthetic application and inoculated with S. aureus (10(2) colony forming units/mL). Four days later, tissue cultures were harvested from control animals and animals given local anesthetic to determine the quantity of bacteria.
  
  
  RESULTS
  The tissue cultures demonstrated that none of the local anesthetics used in the study showed any inhibitory or bactericidal activity on S. aureus. There was no statistical difference in bacterial count between the local anesthetic-treated and control group wounds.
  
  
  CONCLUSIONS
  The results of the present study did not show any antimicrobial activity of above-mentioned local anesthetics in surgically created wounds of rats.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Eskisehir Osmangazi University Medical School, Eskisehir,Turkey. aakose@ogu.edu.tr
authors.forename: A Aydan
authors.initials: AA
authors.lastname: Kose
authors.forename: Yakup
authors.initials: Y
authors.lastname: Karabaggli
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Kiremitci
authors.forename: Emre
authors.initials: E
authors.lastname: Kocman
authors.forename: Cengiz
authors.initials: C
authors.lastname: Cetin
mesh_terms: D000779:Anesthetics, Local / Q000627:therapeutic use*; D000818:Animals; D002045:Bupivacaine / Q000627:therapeutic use; D002355:Carticaine / Q000627:therapeutic use; D004195:Disease Models, Animal; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D011318:Prilocaine / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control*; D013211:Staphylococcus aureus; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000779:Anesthetics, Local; D011318:Prilocaine; D008012:Lidocaine; D002355:Carticaine; D002045:Bupivacaine