title: Estimating the hydration status in nephrotic patients by leg electrical resistivity measuring method.
abstract: OBJECTIVE
  For years, bioelectrical impedance analysis has been widely used to evaluate the hydration status in dialysis patients. However, its value in assessment and controlling the hydration status in non-dialysis patients with kidney disease, such as nephrotic syndrome, is little mentioned. Because a simple and accurate method to evaluate the hydration status of nephrotic patients is not available, the aim of the present study was to assess the value of leg electrical resistivity measurement in controlling the hydration status of nephrotic patients.
  
  
  METHODS
  The study investigated 46 nephrotic patients with a mean age of 41.65 +/- 17.15 years, 47.8% of whom were female. The patients were divided into remission and relapse groups according to their serum albumin concentration and oedema. Four hundred and twenty-seven healthy persons were studied as normal control. Their hydration status estimated by leg electrical resistivity was studied.
  
  
  RESULTS
  There was significant negative correlation between leg electrical resistivity and percentage of extracellular fluid (ECF) measured by the bromide dilution method. The percentage of ECF estimated by the leg electrical resistivity in the relapse group was significantly larger than that of the remission group, but it was approximately the same in the remission group as in the normal control. For nephrotic patients in the relapse group, after they ahcieved remission, their percentage of ECF estimated by the leg electrical resistivity was significantly less than that before treatment, and was close to that of the normal control.
  
  
  CONCLUSIONS
  Leg electrical resistivity measurement is a simple, non-invasive and valuable method for controlling the hydration status in patients with nephrotic syndrome.
authors.affiliation: Nephrology Department, Beijing Chaoyang Hospital, Peking Capital Medical University, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Bo
authors.forename: Taigen
authors.initials: T
authors.lastname: Cui
authors.forename: Yilun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Li
authors.forename: Lijie
authors.initials: L
authors.lastname: Ma
authors.forename: Zengqi
authors.initials: Z
authors.lastname: Bi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D001965:Bromides; D016022:Case-Control Studies; D002681:China; D004487:Edema / Q000209:etiology / Q000503:physiopathology; D017097:Electric Impedance; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007201:Indicator Dilution Techniques; D007866:Leg; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009404:Nephrotic Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D011237:Predictive Value of Tests; D012008:Recurrence; D012709:Serum Albumin / Q000378:metabolism; D017670:Sodium Compounds; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance / Q000187:drug effects; D014883:Water-Electrolyte Imbalance / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D055815:Young Adult
chemical_list: D001965:Bromides; D012709:Serum Albumin; D017670:Sodium Compounds; D013256:Steroids; C027938:sodium bromide