The mitochondrial component of intracrine action.
In recent years the actions of intracellular-acting, extracellular signaling proteins/peptides (intracrines) have become increasingly defined. General principles of intracrine action have been proposed. Mitochondria represent one locus of intracrine action, and thus far, angiotensin II, transforming growth factor-beta, growth hormone, atrial natriuretic peptide, Wnt 13, stanniocalcin, other renin-angiotensin system components, and vascular endothelial-derived growth factor, among others, have been shown to be mitochondria-localizing intracrines. The implications of this mitochondrial intracrine biology are discussed.
Re
Richard N
RN
Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121, USA. rre@ochsner.org
Cook
Julia L
JL
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D015398:Signal Transduction
D047908:Intracellular Signaling Peptides and Proteins; D000804:Angiotensin II