title: Dyslipidaemia, combined oral contraceptives use and their interaction on the risk of hypertension in Chinese women.
abstract: The objective of the study was to assess the associations of dyslipidaemia, combined oral contraceptive (COC) use and their interaction on the risk of hypertension in Chinese women. In a case-control study, we evaluated 665 hypertensive women and 665 normotensive women matched on region and age in China. Hypertensive women had a higher prevalence of dyslipidaemia and higher levels of total cholesterol, triglyceride, low-density lipoprotein-cholesterol and lipoprotein a than normotensive ones (P<0.05). The risk of hypertension gradually increased with the increasing cumulative time of COC use in women (P=0.0043), especially significantly increased among those with cumulative time of COC use 15-20 and ≥20 years (adjusted odds ratio (OR)=1.46, 95% confidence interval (CI): 1.00-2.15; OR=1.49, 95% CI: 1.06-2.11), but gradually decreased from stopping use of COC (P<0.0001). The multiplicative interaction between dyslipidaemia and accumulative time of COC use ≥15 years, dyslipidaemia and family history of hypertension, or family history of hypertension and accumulative time of COC use ≥15 years was confirmed and the interaction analyses showed that they can significantly increased the risk of hypertension (adjusted OR=2.82, 95% CI: 1.59-3.27; OR=4.33, 95% CI: 3.10-6.06; OR=4.56, 95% CI: 3.07-6.77). It is concluded that dyslipidaemia, accumulative time of COC use ≥15 years and their interaction increased the risk of hypertension.
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, PR China.
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: L
authors.initials: L
authors.lastname: Ba
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000208:ethnology / Q000209:etiology; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined; D014280:Triglycerides; D002784:Cholesterol