title: Familial aggregation in atypical Parkinson's disease: a case control study in multiple system atrophy and progressive supranuclear palsy.
abstract: Familial aggregation has been consistently found in PD, but it is unclear whether there is a familial aggregation in families of patients with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). MSA and PSP cases were recruited from a two-arm case control study. One control was matched to each case for age, gender and living area. Medical history of first-degree relatives was obtained through a face-to-face questionnaire. Age-specific cumulative incidence of Parkinsonism and dementia in first-degree relatives of cases and controls was compared for MSA and PSP separately. Seventy-one pairs for MSA and their controls and 79 pairs for PSP and their controls were included. No significant familial aggregation was found in PSP. MSA cases reported Parkinsonism more often, but not dementia in their first-degree relatives than controls. MSA patients, but not those with PSP, have Parkinsonism more often in their first-degree relatives than controls.
authors.affiliation: Intramural Research Program, Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Gateway Building, Suite 3C309, Bethesda, MD 20892-9205, USA. vidaljs@mail.nih.gov
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Vidal
authors.forename: Marie
authors.initials: M
authors.lastname: Vidailhet
authors.forename: Pascal
authors.initials: P
authors.lastname: Derkinderen
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Annick
authors.initials: A
authors.lastname: Alpérovitch
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005190:Family; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000453:epidemiology / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology / Q000235:genetics*; D011795:Surveys and Questionnaires / Q000592:standards