When fibroblasts MET iPSCs.
Two independent studies by Li et al. (2010) and Samavarchi-Tehrani et al. (2010) in this issue of Cell Stem Cell suggest that a mesenchymal-to-epithelial transition is a critical initiating event during the derivation of induced pluripotent stem cells (iPSCs) from fibroblasts, indicating remarkable similarities between cellular reprogramming, development, and cancer.
Polo
Jose M
JM
Howard Hughes Medical Institute at Massachusetts General Hospital, Cancer Center, 185 Cambridge Street, Boston, MA 02114, USA.
Hochedlinger
Konrad
K