GPIHBP1: lipoprotein lipase's ticket to ride.
The mechanism of lipoprotein lipase (LPL) transport from muscle and fat cells to the luminal (apical) surface of capillaries, where it hydrolyses lipoprotein triglycerides, has remained undefined. In this issue, Davies et al. (2010) report that GPIHBP1 is required for LPL transcytosis from the basolateral to apical capillary endothelial surface.
Fisher
Edward A
EA
Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, NY 10016, USA. edward.fisher@nyumc.org