title: The effect of liposome-delivered prednisolone on collagen density, myofibroblasts, and fibrous capsule thickness around silicone breast implants in rats.
abstract: Capsular contracture is a potential adverse effect of breast implants. An inflammatory reaction is most likely the origin of fibrosis around the implant. It is possible that some substances may act to prevent this inflammatory reaction. Thus, our goal was to evaluate the effectiveness of local depot prednisolone phosphate-liposomes (PPL) on fibrous capsule formation around textured silicone breast implants. Shell prostheses (2 mL) were implanted in the right (plus PPL group) and left (plus saline solution, saline group) subcutaneous dorsum of 18 rats. In another 18 rats, the implants were positioned in the left of the back without any drug instillation (control group). In the PPL group, the capsule thickness (microm) and density (%) of collagen were significantly (p<0.0001) lower compared with the control group on days 35 and 90 postsurgery. Furthermore, in the PPL group, a significant reduction in myofibroblast count was observed on day 90 postsurgery (p<0.0001). In conclusion, a single dose of depot liposome-delivered prednisolone was effective at impairing capsule formation around the silicone implant. The results suggest a strong local and weak systemic effect of PPL on the fibrous tissue around silicone implants. To our knowledge, no study has yet assessed the effect of PPL on silicone breast implants.
authors.affiliation: Plastic Surgery Brazilian Society (SBCP), Maringá, PR, Brazil.
authors.forename: Marcio
authors.initials: M
authors.lastname: Moreira
authors.forename: Djalma José
authors.initials: DJ
authors.lastname: Fagundes
authors.forename: Manuel
authors.initials: M
authors.lastname: de Jesus Simões
authors.forename: Murched Omar
authors.initials: MO
authors.lastname: Taha
authors.forename: Luciene Meri Neves
authors.initials: LM
authors.lastname: Perez
authors.forename: Roberto Barbosa
authors.initials: RB
authors.lastname: Bazotte
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018427:Breast Implants / Q000009:adverse effects*; D003094:Collagen / Q000032:analysis / Q000187:drug effects / Q000648:ultrastructure; D003124:Colorimetry; D003286:Contracture / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D005355:Fibrosis / Q000473:pathology; D005549:Foreign-Body Reaction / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000494:pharmacology; D006652:Histological Techniques; D008081:Liposomes; D008297:Male; D010784:Photomicrography; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones / Q000009:adverse effects*; D016037:Single-Blind Method
chemical_list: D005938:Glucocorticoids; D008081:Liposomes; D012828:Silicones; C009022:prednisolone phosphate; D003094:Collagen; D011239:Prednisolone