Enantioselective reduction of ketones and imines catalyzed by (CN-box)Re(V)-oxo complexes.
The development and application of chiral, non-racemic Re(V)-oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer-Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of imines.
Nolin
Kristine A
KA
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Ahn
Richard W
RW
Kobayashi
Yusuke
Y
Kennedy-Smith
Joshua J
JJ
Toste
F Dean
FD
D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D003486:Cyanides; D007097:Imines; D007659:Ketones