title: Severe zinc responsive dermatosis in a litter of Pharaoh Hounds.
abstract: A litter of 3-month-old Pharaoh Hound puppies presented to the referring veterinarian with severe generalized erythematous-crusted papules with pruritus, accompanied by exfoliation and erythema of footpads, inappetence, lethargy, and retarded growth. Three of 5 puppies (2 male and 1 female) were affected. Representative areas were biopsied from 1 affected male puppy and were routinely processed. Histologically, there was marked epidermal hyperplasia with a disorganized appearance of the epidermis and massive parakeratotic hyperkeratosis, compatible with zinc-responsive dermatosis. Low serum zinc concentrations were documented, and the affected animals partially responded to intravenous zinc supplementation but did not respond to oral supplementation. One male puppy died as a result of unrelated causes and was necropsied. The remaining 4 puppies were followed over 2 years. Growth was stunted, and enamel hypoplasia of permanent dentition developed compared with unaffected littermates. Intravenous zinc supplementation at 3-4 week intervals was required to prevent further skin lesion development. One dog died at 3 years of age of renal failure.
authors.affiliation: Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater, OK 74078, USA. gregory.campbell@okstate.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Campbell
authors.forename: Dennis
authors.initials: D
authors.lastname: Crow
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D012871:Skin Diseases / Q000188:drug therapy / Q000662:veterinary*; D015032:Zinc / Q000172:deficiency*; D019287:Zinc Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D019287:Zinc Sulfate; D015032:Zinc