Decreased serum fetuin-A levels are associated with coronary artery diseases.
BACKGROUND
To analyze Fetuin-A levels and soluble cellular adhesion molecules in patients with acute coronary syndrome.


RESULTS
Serum Fetuin-A and intercellular adhesion molecule-1 (sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1) levels were examined in 127 patients who presented with chest pain. These patients were classified in three groups: stable angina (SA, n=51), myocardial infarction (MI, n=34) and non-cardiac group (n=42). Logarithmic transformations were made for Fetuin-A levels. Log-Fetuin-A levels were higher in non-cardiac subjects compared to MI and SA patients (p<0.05). Patients with SA showed lower levels than controls but higher levels as compared to MI patients. After controlling for age and gender, levels of sVCAM-1 and sICAM-1 in patients with coronary atherosclerosis were not different from those in non-cardiac subjects.


CONCLUSIONS
Serum levels of soluble VCAM-1, ICAM-1 were not related to coronary artery disease (CAD), but fetuin-A levels seems to be decreased in SA and MI patients. Low fetuin-A may play a role in the pathophysiology of CAD.
Bilgir
Oktay
O
Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
Kebapcilar
Levent
L
Bilgir
Ferda
F
Bozkaya
Giray
G
Yildiz
Yasar
Y
Pinar
Pelin
P
Tastan
Ahmet
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D012189:Retrospective Studies; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D015415:Biomarkers; D001798:Blood Proteins; D019010:Vascular Cell Adhesion Molecule-1; D060749:alpha-2-HS-Glycoprotein; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein