In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles.
We report protoporphyrin IX (PpIX) encapsulated pH-responsive micelles for cancer treatment. This system showed pH-responsive micellization/demicellization transition at tumoral acidic pH and enabled in vivo tumor diagnosis and therapy simultaneously.
Koo
Heebeom
H
Biomedical Research Center, Korea Institute of Science and Technology, Seongbuk-Gu, Seoul 136-791, South Korea.
Lee
Hyejung
H
Lee
Sojin
S
Min
Kyung Hyun
KH
Kim
Min Sang
MS
Lee
Doo Sung
DS
Choi
Yongseok
Y
Kwon
Ick Chan
IC
Kim
Kwangmeyung
K
Jeong
Seo Young
SY
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008823:Micelles; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D011524:Protoporphyrins / Q000008:administration & dosage*
D004337:Drug Carriers; D008823:Micelles; D017319:Photosensitizing Agents; D011108:Polymers; D011524:Protoporphyrins; C028025:protoporphyrin IX