Effective control of sickle cell disease with hydroxyurea therapy.
OBJECTIVE
Hemoglobin F augmentation is another approach to treat sickle cell disease (SCD). This study evaluates the efficacy and impact of Hydroxyurea (HU) on fetal hemoglobin (HbF) and other hematological parameters, which result in decreasing the painful crisis and lower hospital admissions.


METHODS
A prospective study was carried out in the Department of Medicine, Government Medical College, Jagdalpur. Twenty-seven patients with SCD received HU at a mean dose of 22 mg/kg/d. The baseline results were analyzed and compared with the post treatment result, at the end of one year.


METHODS
Student's t-test was used to determine the level of significance.


RESULTS
Twenty-four patients completed a one-year period successfully; a significant increase was noted in the mean HbF%, from 12.83 to 19.17, and the mean corpuscular volume (MCV) from 82.57 to 89.87 Fl. The mean hospital admission (numbers) in the last one year decreased from 4.75 to 2.25 and the mean number of SCD crisis for the last one year decreased significantly from 3.63 to 1.67.


CONCLUSIONS
We found a significant reduction in hospital admissions, a reduction in the overall sickle cell crisis and an associated improvement in HbF% without any significant side effects in the patients with SCD, treated with HU.
Singh
Harminder
H
Department of Pharmacology, Government Medical College, Jagdalpur, Chhattisgarh, India.
Dulhani
Navin
N
Kumar
Bithika Nel
BN
Singh
Prabhakar
P
Tiwari
Pawan
P