Two new curine-type bisbenzylisoquinoline alkaloids from the roots of Cyclea wattii with cytotoxic activities.
Two new curine-type bisbenzylisoquinoline alkaloids, wattisines A (1) and B (2) along with three known alkaloids were isolated from the roots of Cyclea wattii. Their structures were established by interpretation of NMR and high-resolution electrospray ionization (ESI)-MS data. Absolute configuration of wattisines A and B were determined by single-crystal X-ray diffraction and circular dichroism (CD) spectra, respectively. In vitro, wattisine A (1) showed significant cytotoxic activities with IC(50) value of 1.74 microM against HCT-8, and 7.29 microM against Bel-7402.
Wang
Jian-Zhong
JZ
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
Liu
Xiao-Yu
XY
Wang
Feng-Peng
FP
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D044182:Benzylisoquinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D031604:Cyclea / Q000737:chemistry*; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry
D000470:Alkaloids; D044182:Benzylisoquinolines; D007546:Isoquinolines; C552659:wattisine A; C552660:wattisine B; C470478:curine