Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.
BACKGROUND
Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.


METHODS
Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).


RESULTS
In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.


CONCLUSIONS
Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.
Sezgin
Efe
E
Laboratory of Genomic Diversity, SAIC-Frederick, National Cancer Institute, Frederick, Maryland 21702-1201, USA. sezginef@mail.nih.gov
Jabs
Douglas A
DA
Hendrickson
Sher L
SL
Van Natta
Mark
M
Zdanov
Alexander
A
Lewis
Richard Alan
RA
Smith
Michael W
MW
Troyer
Jennifer L
JL
O'Brien
Stephen J
SJ
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001741:Black or African American; D017726:Cytomegalovirus Retinitis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D016753:Interleukin-10 / Q000235:genetics; D053709:Interleukin-10 Receptor alpha Subunit / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014481:United States; D044465:White People
D053709:Interleukin-10 Receptor alpha Subunit; D016753:Interleukin-10