title: New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy.
abstract: The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH(2), HFRWRQIKIWFQNRRMKWKK-NH(2) and RQPKIWFPNRRKPWKK-NH(2) acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods.
authors.affiliation: Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, 5700 San Luis, Argentina.
authors.forename: Mónica S
authors.initials: MS
authors.lastname: Olivella
authors.forename: Ana M
authors.initials: AM
authors.lastname: Rodríguez
authors.forename: Susana A
authors.initials: SA
authors.lastname: Zacchino
authors.forename: Csaba
authors.initials: C
authors.lastname: Somlai
authors.forename: Botond
authors.initials: B
authors.lastname: Penke
authors.forename: Victor
authors.initials: V
authors.lastname: Farkas
authors.forename: András
authors.initials: A
authors.lastname: Perczel
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Enriz
mesh_terms: D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002942:Circular Dichroism; D003455:Cryptococcus neoformans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017433:Protein Structure, Secondary
chemical_list: D000935:Antifungal Agents; D010455:Peptides