Levodopa/benserazide-loaded biodegradable microspheres reduce dyskinesia in rats.
Parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia niara. Levodopa remains the most effective drug in the treatment of Parkinson's disease. Unfortunately, with disease progression, levodopa reduces Parkinsonism at the cost of evoking abnormal involuntary movements known as levodopa-induced dyskinesia (LID). In this study, we found that levodopa/benserazide-loaded biodegradable microspheres reduce the expression of LID, which was easily evoked by administrating of the same dose of levodapa and benserazide in rats with Parkinson's disease. Moreover, levodopa/benserazide-loaded biodegradable microspheres can improve the stepping of the lesioned forepaw in rats with Parkinson's disease. These data showed that levodopa/benserazide-loaded biodegradable microspheres might be useful in the treatment of Parkinson's disease and reducing the expression of LID in rats.
Yang
Xinxin
X
Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Yuan
Weien
W
Ren
Tianan
T
Song
Lu
L
Wu
Na
N
Liu
Zhenguo
Z
D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage; D001545:Benserazide / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000378:metabolism*; D004195:Disease Models, Animal; D018450:Disease Progression; D004338:Drug Combinations; D004357:Drug Synergism; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D007794:Lameness, Animal / Q000188:drug therapy / Q000209:etiology; D007980:Levodopa / Q000008:administration & dosage*; D008863:Microspheres; D020734:Parkinsonian Disorders / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
D000978:Antiparkinson Agents; D001672:Biocompatible Materials; D004338:Drug Combinations; D007980:Levodopa; D001545:Benserazide