Life-threatening haemorrhage secondary to nicorandil-induced severe peri-anal ulceration.
Nicorandil-induced ulceration is rare but has been reported at multiple sites throughout the gastrointestinal tract. We report a life-threatening complication of such ulceration - catastrophic per-rectal haemorrhage requiring emergency surgery with no prior symptoms. Whilst nicorandil should be considered in cases of chronic peri-anal and peristomal ulceration which fail to respond to conventional treatments, this case highlights its importance in the setting of acute surgical presentations.
Mosley
F
F
Department of General Surgery, Bradford Royal Infirmary, Bradford, UK. Frances_Mosley@yahoo.co.uk
Bhasin
N
N
Davies
J B
JB
Ausobsky
J R
JR
D000208:Acute Disease; D000368:Aged; D001004:Anus Diseases / Q000209:etiology; D005401:Fissure in Ano / Q000139:chemically induced* / Q000150:complications / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D020108:Nicorandil / Q000009:adverse effects*; D014665:Vasodilator Agents / Q000009:adverse effects*
D014665:Vasodilator Agents; D020108:Nicorandil