title: Modeling biomedical experimental processes with OBI.
abstract: BACKGROUND
  Experimental descriptions are typically stored as free text without using standardized terminology, creating challenges in comparison, reproduction and analysis. These difficulties impose limitations on data exchange and information retrieval.
  
  
  RESULTS
  The Ontology for Biomedical Investigations (OBI), developed as a global, cross-community effort, provides a resource that represents biomedical investigations in an explicit and integrative framework. Here we detail three real-world applications of OBI, provide detailed modeling information and explain how to use OBI.
  
  
  CONCLUSIONS
  We demonstrate how OBI can be applied to different biomedical investigations to both facilitate interpretation of the experimental process and increase the computational processing and integration within the Semantic Web. The logical definitions of the entities involved allow computers to unambiguously understand and integrate different biological experimental processes and their relevant components.
  
  
  BACKGROUND
  OBI is available at http://purl.obolibrary.org/obo/obi/2009-11-02/obi.owl.
authors.affiliation: British Columbia Cancer Agency, Vancouver, Canada. rbrinkman@bccrc.ca.
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Brinkman
authors.forename: Mélanie
authors.initials: M
authors.lastname: Courtot
authors.forename: Dirk
authors.initials: D
authors.lastname: Derom
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Fostel
authors.forename: Yongqun
authors.initials: Y
authors.lastname: He
authors.forename: Phillip
authors.initials: P
authors.lastname: Lord
authors.forename: James
authors.initials: J
authors.lastname: Malone
authors.forename: Helen
authors.initials: H
authors.lastname: Parkinson
authors.forename: Bjoern
authors.initials: B
authors.lastname: Peters
authors.forename: Philippe
authors.initials: P
authors.lastname: Rocca-Serra
authors.forename: Alan
authors.initials: A
authors.lastname: Ruttenberg
authors.forename: Susanna-Assunta
authors.initials: SA
authors.lastname: Sansone
authors.forename: Larisa N
authors.initials: LN
authors.lastname: Soldatova
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Stoeckert
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Turner
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng