title: Discussion on "A Hybrid Selection and Testing Procedure with Curtailment for Comparative Clinical Trials" by Elena M. Buzaianu and Pinyuen Chen.
abstract: Buzaianu and Chen apply strong curtailment to modify the two-stage select-and-test clinical trial design proposed by Thall et al. (1988). The modification reduces the expected sample size while maintaining overall power but requires continuous monitoring in stage 1. I will review the history of this type of design and discuss practical issues related to the use of strong curtailment that arise in trial conduct.
authors.affiliation: Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Peter F
authors.initials: PF
authors.lastname: Thall