title: [How to minimize weight gain associated with insulin treatment].
abstract: Insulin treatment is associated with two important and frequent side effects: hypoglycemia and weight gain. Weight gain is in contradiction with the physiological central effect of insulin which leads to decreased food intake like leptin. However, decreased urinary caloric loss due to better glycemic control, prevention and correction of hypoglycemia, the anabolic effect of insulin and the possible central resistance to insulin explain the observed weight gain. Insulin is often necessary when oral antidiabetic treatment fails; the physician and the patient need to remain alert to minimize the side effects through adequate insulin regimen and life style.
authors.affiliation: Service d'endocrinologie, diabétologie et nutrition, Département de médecine interne, HUG, Genève. Jacques.Philippe@hcuge.ch
authors.forename: Jacques
authors.initials: J
authors.lastname: Philippe
mesh_terms: D031204:Caloric Restriction; D003920:Diabetes Mellitus / Q000188:drug therapy; D015444:Exercise; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007328:Insulin / Q000009:adverse effects* / Q000627:therapeutic use; D008019:Life Style; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin