A nonsynonymous polymorphism in IL23R gene is associated with risk of gastric cancer in a Chinese population.
Interleukin-23 receptor (IL-23R) is a key element in T helper (Th)17 cell-mediated inflammatory process, which plays an important role in pathogenesis of gastric cancer. Genetic variants of IL-23R have been identified as the predisposing factors for immunopathologic process. In this study, we hypothesized that the functional genetic variants of IL-23R gene may modify the risk of gastric cancer. To test this hypothesis, we conducted a case-control study including 1043 gastric cancer patients and 1089 controls in a Chinese population to assess the association between two potentially functional single nucleotide polymorphisms (SNPs) rs6682925 T>C and rs1884444 T>G of IL-23R and risk of gastric cancer. We found that the variant allele (G) of rs1884444 T>G, with amino acid His substituted by Gln at codon 3, was significantly associated with a decreased risk of gastric cancer [adjusted allelic odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.68-0.88]. In the stratified analysis, we found that this protective effect of rs1884444 G allele was mainly evident in intestinal-type gastric cancer (adjusted allelic OR = 0.75, 95% CI = 0.65-0.87) other than in diffuse-type gastric cancer (adjusted allelic OR = 0.96, 95% CI = 0.76-1.22). However, we did not find any significant association of rs6682925 T>C with gastric cancer risk. These findings indicate, for the first time, that the nonsynonymous variant rs1884444 T>G of IL-23R may contribute to gastric cancer susceptibility, especially in intestinal-type gastric cancer, in Chinese population.
Chen
Jianjian
J
Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Lu
Yan
Y
Zhang
Hanze
H
Ding
Yanbing
Y
Ren
Chuanli
C
Hua
Zhaolai
Z
Zhou
Yan
Y
Deng
Bin
B
Jin
Guangfu
G
Hu
Zhibin
Z
Xu
Yaochu
Y
Shen
Hongbing
H
D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
C515500:IL23R protein, human; D018123:Receptors, Interleukin