title: [Evaluation of transhepatic artery chemotherapy for highly advanced hepatocellular carcinoma].
abstract: We conducted transhepatic arterial infusion chemotherapy (TAI) was on 62 patients with highly advanced hepatocellular carcinoma without distant metastases and therapeutic outcome was compared with 18 who were untreated. TAI significantly prolonged the survival of the patients, and was the most important prognostic factor on multivariate analysis. The following 3 regimens for trans-arterial injection were compared: A, a combination of a bolus hepatic artery injection of 3 agents (cisplatin, mitomycin-C and epirubicin)+low dose 5-fluorouracil+cisplatin (FP); B, low-dose FP alone; and C, bolus intrahepatic artery injection of the above 3 agents combined without FP. Regimen A yielded in the most effective survival rate, with an efficacy rate of 41.6% and a CR of about 20%. These results indicate that TAI is an effective therapeutic modality, and the dose FP combined with a bolus intrahepatic arterial infusion may improve outcomes in advanced liver cancer.
authors.affiliation: Department of Internal Medicine, Kagoshima Kouseiren Hospital. hiramine0630@yahoo.co.jp
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Hiramine
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Imamura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Uto
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Baba
authors.forename: Takuya
authors.initials: T
authors.lastname: Hiwaki
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Sho
authors.forename: Kenji
authors.initials: K
authors.lastname: Tahara
authors.forename: Hirohito
authors.initials: H
authors.lastname: Tsubouchi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage*; D015251:Epirubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D015251:Epirubicin; D016685:Mitomycin; D002945:Cisplatin