title: Review: modelling the dialysate.
abstract: Dialysate prescription is evolving as new technology allows greater opportunity to alter dialysate constituents throughout dialysis, providing scope for tailored prescription for an individual patient. The intention of modelling or profiling is to improve the tolerability of dialysis and long-term patient outcomes. This approach can be applied to both electrolytes and water. Despite these advances in technology, benefits of modelling have not been demonstrated consistently. This review examines the use of individual prescription and modelling of dialysate sodium, ultrafiltrate, potassium, calcium, magnesium, bicarbonate and phosphate.
authors.affiliation: Centre for Transplantation and Renal Research, Westmead Millennium Institute, Department of Renal Medicine, Westmead Hospital, Sydney, New South Wales, Australia. phipps.lisa@gmail.com
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Phipps
authors.forename: David C H
authors.initials: DC
authors.lastname: Harris
mesh_terms: D001639:Bicarbonates / Q000097:blood; D002118:Calcium / Q000097:blood; D019317:Evidence-Based Medicine; D015312:Hemodialysis Solutions / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D057285:Precision Medicine; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D012964:Sodium / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001639:Bicarbonates; D015312:Hemodialysis Solutions; D010710:Phosphates; D012964:Sodium; D011188:Potassium; D002118:Calcium