Design and synthesis of a novel fluorescence probe for Zn2+ based on the spirolactam ring-opening process of rhodamine derivatives.
The spirolactam ring-opening process of rhodamine derivative is one of the most useful mechanisms for controlling fluorescence properties. However, the open/closed equilibrium reaction of rhodamine spirolactam has not been well characterized. Therefore, we examined the relationship between the spirolactam ring-opening process of rhodamine derivatives and the structure of the xanthene moiety. Based on the results of this investigation, we selected a candidate xanthene moiety for a Zn(2+) sensor, and successfully developed a new fluorescence probe for Zn(2+).
Sasaki
Hiromi
H
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Hanaoka
Kenjiro
K
Urano
Yasuteru
Y
Terai
Takuya
T
Nagano
Tetsuo
T
D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007477:Ions / Q000032:analysis / Q000737:chemistry; D055668:Photochemical Processes; D012235:Rhodamines / Q000737:chemistry*; D015032:Zinc / Q000032:analysis* / Q000737:chemistry
D005456:Fluorescent Dyes; D007477:Ions; D012235:Rhodamines; D015032:Zinc