title: Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols.
abstract: A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.
authors.affiliation: Departamento de Química, Area de Química Orgánica, Facultad de Ciencias, Universidad de Burgos, Pza. Misael Bañuelos s/n, 09001, Burgos, Spain. rsd@ubu.es
authors.forename: Roberto
authors.initials: R
authors.lastname: Sanz
authors.forename: Verónica
authors.initials: V
authors.lastname: Guilarte
authors.forename: Nuria
authors.initials: N
authors.lastname: García
mesh_terms: D000478:Alkylation; D006219:Halogens / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*
chemical_list: D006219:Halogens; D007211:Indoles; D010636:Phenols