[Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis].
Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
Hwang
Sena
S
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Kim
Do Young
DY
Kim
Minju
M
Chon
Young Eun
YE
Lee
Hyun Jung
HJ
Park
Young-Nyun
YN
Park
Jun Yong
JY
Ahn
Sang Hoon
SH
Han
Kwang-Hyub
KH
Chon
Chae Yoon
CY
D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D011169:Portal Vein; D020151:Protein C Deficiency / Q000150:complications*; D018455:Protein S Deficiency / Q000150:complications*; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult