Immunotherapeutic polyoma and human papilloma virus-like particles.
Polyomavirus and human papillomavirus (HPV) virus-like particles (VLPs) can be obtained by producing their major capsid protein VP1 (for polyomavirus) or L1 (for HPV) free from other viral genes in, for example, a baculovirus insect system, yeast, Escherichia coli or similar systems. Polyomavirus and HPV VLPs can immunize healthy individuals, and in some cases T-cell-deficient hosts, against primary infection with the corresponding virus. Chimeric VLPs from polyomaviruses or HPVs containing fusion proteins between the VP1/L1 or VP2/VP3/L2 minor capsid proteins and selected antigens can also be produced. These VLPs can then induce B- or T-cell immune responses and be used as preventive or therapeutic vaccines against cancers induced by the corresponding virus, or a cancer bearing the selected tumor antigen.
Ramqvist
Torbjörn
T
Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:01, 171 76 Stockholm, Sweden.
Dalianis
Tina
T
D052685:Alphapapillomavirus / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism; D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology; D036022:Capsid Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007114:Immunization; D007167:Immunotherapy; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D011120:Polyomavirus / Q000235:genetics / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects / Q000473:pathology; D014771:Virion / Q000235:genetics / Q000378:metabolism*
D000951:Antigens, Neoplasm; D036022:Capsid Proteins; C114580:HPV L1 protein, Human papillomavirus; D009856:Oncogene Proteins, Viral; D011993:Recombinant Fusion Proteins; C062481:VP1 protein, polyomavirus