title: Stereoselective ring contraction of 2,5-diketopiperazines: An innovative approach to the synthesis of promising bioactive 5-membered scaffolds.
abstract: Ring contraction of 2,5-diketopiperazines by TRAL-alkylation led us to the stereoselective synthesis of original pyrrolidine-2,4-diones, a novel series of promising molecules with moderate anti-proliferative activity on breast cancer cells.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR CNRS-Université Montpellier, France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Coursindel
authors.forename: Audrey
authors.initials: A
authors.lastname: Restouin
authors.forename: Georges
authors.initials: G
authors.lastname: Dewynter
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Yves
authors.initials: Y
authors.lastname: Collette
authors.forename: Isabelle
authors.initials: I
authors.lastname: Parrot
mesh_terms: D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D049109:Cell Proliferation / Q000187:drug effects; D054659:Diketopiperazines / Q000138:chemical synthesis / Q000737:chemistry*; D005260:Female; D006801:Humans; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D054659:Diketopiperazines; D011759:Pyrrolidines