title: In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles.
abstract: We report protoporphyrin IX (PpIX) encapsulated pH-responsive micelles for cancer treatment. This system showed pH-responsive micellization/demicellization transition at tumoral acidic pH and enabled in vivo tumor diagnosis and therapy simultaneously.
authors.affiliation: Biomedical Research Center, Korea Institute of Science and Technology, Seongbuk-Gu, Seoul 136-791, South Korea.
authors.forename: Heebeom
authors.initials: H
authors.lastname: Koo
authors.forename: Hyejung
authors.initials: H
authors.lastname: Lee
authors.forename: Sojin
authors.initials: S
authors.lastname: Lee
authors.forename: Kyung Hyun
authors.initials: KH
authors.lastname: Min
authors.forename: Min Sang
authors.initials: MS
authors.lastname: Kim
authors.forename: Doo Sung
authors.initials: DS
authors.lastname: Lee
authors.forename: Yongseok
authors.initials: Y
authors.lastname: Choi
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
authors.forename: Seo Young
authors.initials: SY
authors.lastname: Jeong
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008823:Micelles; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D011524:Protoporphyrins / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D008823:Micelles; D017319:Photosensitizing Agents; D011108:Polymers; D011524:Protoporphyrins; C028025:protoporphyrin IX