title: Role of phIGFBP-1 and ultrasound cervical length in predicting pre-term labour.
abstract: This prospective observational study was to evaluate the efficacy of combining phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) and transvaginal ultrasound cervical length (CL) compared with either indicator alone in predicting pre-term labour (PTL). Women with singleton pregnancy between 24 and 36 weeks' gestation with evidence of PTL were subjected to phIGFBP-1 and CL tests. Of the 51 women, five were tested positive (phIGFBP-1 positive and CL <2.5 cm) for combination of phIGFBP-1 and CL (four delivered within 1 week), whereas 46 tested negative, of which, only one delivered. A much higher negative predictivity (NP), positive predictivity (PP) and specificity (SP) in the combination test was seen compared with phIGFBP-1 or CL alone (NP: 97.8% vs 97.7% vs 97.1%; PP: 80.0% vs 51.1% and CL 23.5%; SP: 97.8% vs 93.5% vs 71.1%, respectively). The cervical os dilatation of 2 cm with combined positive test (p = 0.001) indicated a higher likelihood of PTL.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. azlinm@ppukm.ukm.my
authors.forename: M I Nor
authors.initials: MI
authors.lastname: Azlin
authors.forename: H Kee
authors.initials: HK
authors.lastname: Bang
authors.forename: L Joe
authors.initials: LJ
authors.lastname: An
authors.forename: S N
authors.initials: SN
authors.lastname: Mohamad
authors.forename: N A
authors.initials: NA
authors.lastname: Mansor
authors.forename: B See
authors.initials: BS
authors.lastname: Yee
authors.forename: N H
authors.initials: NH
authors.lastname: Zulkifli
authors.forename: A Mohd
authors.initials: AM
authors.lastname: Tamil
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D054791:Cervical Length Measurement; D002584:Cervix Uteri / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D007752:Obstetric Labor, Premature / Q000000981:diagnostic imaging* / Q000378:metabolism; D010766:Phosphorylation / Q000502:physiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000592:standards; D055815:Young Adult
chemical_list: D015415:Biomarkers; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1