Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology.
Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-kappaB/IkappaB and HIF-1alpha pathways). Thus, it could have an important role in the development of the pituitary tumors.
Fuertes
Mariana
M
Gerez
Juan
J
Haedo
Mariana
M
Giacomini
Damiana
D
Páez-Pereda
Marcelo
M
Labeur
Marta
M
Stalla
Günter K
GK
Arzt
Eduardo
E
D000818:Animals; D050822:Cytokine Receptor gp130 / Q000502:physiology*; D020869:Gene Expression Profiling; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D010911:Pituitary Neoplasms / Q000209:etiology*; D014157:Transcription Factors / Q000502:physiology*
D015850:Interleukin-6; C525338:RWDD3 protein, human; D014157:Transcription Factors; D050822:Cytokine Receptor gp130