title: Plasma carbonic anhydrase II protein is elevated in Alzheimer's disease.
abstract: Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.
authors.affiliation: Division of Brain Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, Korea.
authors.forename: Bong Geom
authors.initials: BG
authors.lastname: Jang
authors.forename: Sang-Moon
authors.initials: SM
authors.lastname: Yun
authors.forename: Kyungsook
authors.initials: K
authors.lastname: Ahn
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Song
authors.forename: Sangmee A
authors.initials: SA
authors.lastname: Jo
authors.forename: Young-Yul
authors.initials: YY
authors.lastname: Kim
authors.forename: Doh Kwan
authors.initials: DK
authors.lastname: Kim
authors.forename: Moon Ho
authors.initials: MH
authors.lastname: Park
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Koh
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D000704:Analysis of Variance; D015153:Blotting, Western; D024402:Carbonic Anhydrase II / Q000097:blood*; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D024402:Carbonic Anhydrase II