title: Serum prolidase activity in idiopathic and ischemic cardiomyopathy patients.
abstract: Idiopathic and ischemic dilated cardiomyopathies (DCM) are the most common types of DCM, and both exhibit the same histopathological feature of fibrosis. Prolidase is an enzyme that serves a rate-limiting function in collagen turnover. Several studies have shown increased prolidase activity in fibrosis, though controversy persists. In this study, we measured prolidase enzyme activity in patients with idiopathic or ischemic DCM and in healthy controls, making this, to our knowledge, the first study to do so. What we found is that serumprolidase activity was significantly lower in both DCM groups relative to healthy volunteers and lower in ischemic DCM than idiopathic. These intriguing results could be attributed either to decreased collagen turnover in the heart tissues in which DCM develops, a result of diminished functional heart tissue, or to decreased physical activity levels among DCM patients stemming from their heart failure. Either way, further studies are needed to verify and clarify our results.
authors.affiliation: Department of Cardiology, Harran University School of Medicine, Sanliurfa, Turkey. yusufsezen@harran.edu.tr
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sezen
authors.forename: Memduh
authors.initials: M
authors.lastname: Bas
authors.forename: Halil
authors.initials: H
authors.lastname: Altiparmak
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.forename: Hakan
authors.initials: H
authors.lastname: Buyukhatipoglu
authors.forename: Omer
authors.initials: O
authors.lastname: Faruk Dag
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kaya
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000704:Analysis of Variance; D002311:Cardiomyopathy, Dilated / Q000201:enzymology*; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000201:enzymology*
chemical_list: D004150:Dipeptidases; C022449:proline dipeptidase