title: Variability of the bla(IMP-15)-containing integrons, highly related to In95, on an endemic clone of Pseudomonas aeruginosa in Mexico.
abstract: The acquisition of β-lactamases, such as class B metallo-β-lactamases, in Pseudomonas aeruginosa is detrimental to antimicrobial therapy in hospitalized patients. In Mexico, metallo-β-lactamase IMP-15 has been found to be encoded on the In95 class 1 integron in a major clone of P. aeruginosa. In this work, we describe the variability of this class 1 integron in an epidemic clone of carbapenem-resistant P. aeruginosa clinical isolates highly related to isolates previously described in Mexico.
authors.affiliation: Departamento de Resistencia Bacteriana, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
authors.forename: Jesus Ulises
authors.initials: JU
authors.lastname: Garza-Ramos
authors.forename: Guillermina
authors.initials: G
authors.lastname: Sanchez-Martinez
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Barajas
authors.forename: Sandra
authors.initials: S
authors.lastname: Suarez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sanchez-Perez
authors.forename: Teresa
authors.initials: T
authors.lastname: Rojas-Moreno
authors.forename: Berta
authors.initials: B
authors.lastname: Carrillo-Quiroz
authors.forename: Jesus
authors.initials: J
authors.lastname: Silva-Sanchez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D016521:Electrophoresis, Gel, Pulsed-Field; D019353:Endemic Diseases; D014644:Genetic Variation; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D032023:Integrons / Q000235:genetics*; D008800:Mexico / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D015378:Imipenem; D001618:beta-Lactamases; C547882:beta-lactamase IMP-15, Pseudomonas aeruginosa