title: Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - relationship to auditory event-related potentials.
abstract: Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments.
authors.affiliation: Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK. james.m.stone@imperial.ac.uk
authors.forename: James M
authors.initials: JM
authors.lastname: Stone
authors.forename: Elvira
authors.initials: E
authors.lastname: Bramon
authors.forename: Astrid
authors.initials: A
authors.lastname: Pauls
authors.forename: Alex
authors.initials: A
authors.lastname: Sumich
authors.forename: Philip K
authors.initials: PK
authors.lastname: McGuire
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009448:Neurochemistry; D011522:Protons; D011877:Radionuclide Imaging; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D013788:Thalamus / Q000378:metabolism*; D055815:Young Adult
chemical_list: D011522:Protons; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate