title: Roles of titin in the structure and elasticity of the sarcomere.
abstract: The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest length, its operating range of lengths, and passive elastic properties are also directly controlled by the properties of titin. Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity.
authors.affiliation: Institute for Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
authors.forename: Larissa
authors.initials: L
authors.lastname: Tskhovrebova
authors.forename: John
authors.initials: J
authors.lastname: Trinick
mesh_terms: D000818:Animals; D064211:Connectin; D004548:Elasticity; D006801:Humans; D009124:Muscle Proteins / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D009218:Myosins / Q000378:metabolism; D018583:Pliability; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D012518:Sarcomeres / Q000737:chemistry* / Q000502:physiology*
chemical_list: D064211:Connectin; D009124:Muscle Proteins; C577285:TTN protein, human; D011494:Protein Kinases; D009218:Myosins