Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.
High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI 0.86-1.12, p=0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE ε4. Genetic deficiency of Lp-PLA2 activity is not associated with a reduced risk of AD in the Japanese population.
Koshy
Beena
B
Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.
Miyashita
Akinori
A
St Jean
Pamela
P
Stirnadel
Heide
H
Kaise
Toshihiko
T
Rubio
Justin P
JP
Mooser
Vincent
V
Kuwano
Ryozo
R
Irizarry
Michael C
MC
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D009154:Mutation; D054467:Phospholipases A2 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
D001057:Apolipoproteins E; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human