title: Mineral trioxide aggregate-based sealer: analysis of tissue reactions to a new endodontic material.
abstract: BACKGROUND
  The aim of this study was to evaluate the subcutaneous connective tissue reaction to mineral trioxide aggregate (MTA)-based sealer (Endo CPM Sealer; CPM Sealer; EGEO SRL, Buenos Aires, Argentina), MTA, and an epoxy resin-based sealer (AH Plus; Dentsply HERO Indústria e Comércio Ltda, Petrópolis, RJ, Brazil).
  
  
  METHODS
  Polyethylene tubes containing the test materials and empty tubes (control group) were implanted in the subcutaneous tissue of 18 rats. After 7, 30, and 60 days, observations were made for cellular inflammatory components, fibrous condensation, and abscess formation. Comparisons between groups and periods of time were made using the Friedman test and the Kruskall-Wallis test.
  
  
  RESULTS
  Lymphocytes and plasmacytes were more intensely observed in the reaction to AH Plus sealer after 30 days (p < 0.05). MTA and the Endo CPM Sealer presented a behavior similar to that of the control group throughout the whole experiment.
  
  
  CONCLUSIONS
  The Endo CPM Sealer presented biological potential. Characteristics of the inflammatory reaction were equivalent to those produced by MTA.
authors.affiliation: School of Dentistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. robks@terra.com.br
authors.forename: Roberta Kochenborger
authors.initials: RK
authors.lastname: Scarparo
authors.forename: Daniel
authors.initials: D
authors.lastname: Haddad
authors.forename: Gerson Arison Xavier
authors.initials: GA
authors.lastname: Acasigua
authors.forename: Anna Cristina Medeiros
authors.initials: AC
authors.lastname: Fossati
authors.forename: Elaine Vianna Freitas
authors.initials: EV
authors.lastname: Fachin
authors.forename: Fabiana Soares
authors.initials: FS
authors.lastname: Grecca
mesh_terms: D000038:Abscess / Q000145:classification; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D017610:Calcium Compounds / Q000494:pharmacology*; D003094:Collagen / Q000648:ultrastructure; D003238:Connective Tissue / Q000187:drug effects; D004338:Drug Combinations; D004853:Epoxy Resins / Q000494:pharmacology; D005355:Fibrosis; D015726:Giant Cells / Q000473:pathology; D007249:Inflammation; D008214:Lymphocytes / Q000473:pathology; D008422:Materials Testing; D010087:Oxides / Q000494:pharmacology*; D010950:Plasma Cells / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*; D040521:Subcutaneous Tissue / Q000187:drug effects; D013997:Time Factors
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D004338:Drug Combinations; C540763:Endo-CPM-Sealer; D004853:Epoxy Resins; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C534916:epoxy resin-based root canal sealer; C086631:mineral trioxide aggregate; D003094:Collagen