NF-κB DNA binding activity of sesquiterpene lactones from Anthemis arvensis and Anthemis cotula.
Previous investigations of Anthemis arvensis L. and Anthemis cotula L., species growing wild in Serbia, revealed linear sesquiterpene lactones (SLs) with unusual types of skeleton, named antheindurolides and anthecotuloides. The NF-κB DNA binding activity of four of those SLs as well as from compounds representing structural parts of the SLs is reported in this article. The relationship between their structure and NF-κB inhibition potency is briefly discussed.
Vucković
Ivan
I
Institute of Chemistry, Technology and Metallurgy, 11000 Belgrade, Serbia.
Vujisić
Ljubodrag
L
Klaas
Christoph A
CA
Merfort
Irmgard
I
Milosavljević
Slobodan
S
D031166:Anthemis / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D019169:Jurkat Cells; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007783:Lactones; D016328:NF-kappa B; D012717:Sesquiterpenes; D004247:DNA