title: The demographic and biomedical case for late-life interventions in aging.
abstract: The social and medical costs of the biological aging process are high and will rise rapidly in coming decades, creating an enormous challenge to societies worldwide. In recent decades, researchers have expanded their understanding of the underlying deleterious structural and physiological changes (aging damage) that underlie the progressive functional impairments, declining health, and rising mortality of aging humans and other organisms and have been able to intervene in the process in model organisms, even late in life. To preempt a global aging crisis, we advocate an ambitious global initiative to translate these findings into interventions for aging humans, using three complementary approaches to retard, arrest, and even reverse aging damage, extending and even restoring the period of youthful health and functionality of older people.
authors.affiliation: Strategies for Engineered Negligible Senescence (SENS) Foundation, Sunnyvale, CA 94089, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rae
authors.forename: Robert N
authors.initials: RN
authors.lastname: Butler
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.forename: Aubrey D N J
authors.initials: AD
authors.lastname: de Grey
authors.forename: Caleb E
authors.initials: CE
authors.lastname: Finch
authors.forename: Michael
authors.initials: M
authors.lastname: Gough
authors.forename: George M
authors.initials: GM
authors.lastname: Martin
authors.forename: Jan
authors.initials: J
authors.lastname: Vijg
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Perrott
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Logan
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology*; D003710:Demography; D006291:Health Policy; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D011634:Public Health / Q000706:statistics & numerical data; D044968:Regenerative Medicine / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends*