title: Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis.
abstract: Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.
authors.affiliation: Biospectrum Life Science Institute, Gunpo, Gyunggi Do 435-833, Republic of Korea.
authors.forename: Sungran
authors.initials: S
authors.lastname: Huh
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Eunsun
authors.initials: E
authors.lastname: Jung
authors.forename: Jihee
authors.initials: J
authors.lastname: Lim
authors.forename: Kwang Sun
authors.initials: KS
authors.lastname: Jung
authors.forename: Myeong-Ok
authors.initials: MO
authors.lastname: Kim
authors.forename: Jongsung
authors.initials: J
authors.lastname: Lee
authors.forename: Deokhoon
authors.initials: D
authors.lastname: Park
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002849:Chromatography, Gas; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice
chemical_list: D004952:Esters; D005227:Fatty Acids; D008543:Melanins; D000242:Cyclic AMP