Optical probes for molecular processes in live cells.
In this review, I summarize the development over the past several years of fluorescent and/or bioluminescent indicators to pinpoint cellular processes in living cells. These processes involve second messengers, protein phosphorylations, protein-protein interactions, protein-ligand interactions, nuclear receptor-coregulator interactions, nucleocytoplasmic trafficking of functional proteins, and protein localization.
Umezawa
Yoshio
Y
Department of Chemistry, University of Tokyo, Japan. umezawa@chem.s.u-tokyo.ac.jp
D000595:Amino Acid Sequence; D000818:Animals; D002477:Cells / Q000166:cytology*; D003584:Cytological Techniques; D006801:Humans; D007295:Inositol Phosphates / Q000737:chemistry; D008024:Ligands; D049449:Luminescence; D008164:Luminescent Proteins / Q000737:chemistry; D008856:Microscopy, Fluorescence / Q000379:methods; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000737:chemistry; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry
D007295:Inositol Phosphates; D008024:Ligands; D008164:Luminescent Proteins; D011506:Proteins; C118500:inositol 3,4,5-trisphosphate; D009569:Nitric Oxide