title: Sestrins at the crossroad between stress and aging.
abstract: Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
authors.affiliation: Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Rolf
authors.initials: R
authors.lastname: Bodmer
authors.forename: Ethan
authors.initials: E
authors.lastname: Bier
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D025461:Feedback, Physiological / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D006360:Heat-Shock Proteins; D009687:Nuclear Proteins