Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population.
The serotoninergic system has been implicated in the etiology of schizophrenia and other behavioral disorders. Association studies have focused on the tryptophan hydroxylase 2 gene (TPH2) and the 5-hydroxytryptamine receptor 2A gene (5-HTR2A). We genotyped two single-nucleotide polymorphisms, A1438G of 5-HTR2A and intronic rs1386494 of TPH2 in the Malay population, using a sample size of 289 schizophrenic patients and 130 healthy controls. We found a significant association of A1438G of 5-HTR2A with schizophrenia in Malays. On the other hand, TPH2 polymorphism was not associated with schizophrenia. This is the first genetic association study concerning schizophrenia in the Malay population.
Tee
S F
SF
Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Jalan Genting Kelang, Setapak, Kuala Lumpur, Malaysia.
Chow
T J
TJ
Tang
P Y
PY
Loh
H C
HC
D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008296:Malaysia / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase