Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation.
Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations.
Chen
Wenlan
W
Departments of Chemistry and Biochemistry, The Ohio State University, Columbus, 43210, USA.
Xia
Chengfeng
C
Cai
Li
L
Wang
Peng George
PG
D000818:Animals; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D055611:Natural Killer T-Cells / Q000187:drug effects* / Q000276:immunology; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
D005699:Galactosylceramides