title: A multidisciplinary investigation of a polycythemia vera cancer cluster of unknown origin.
abstract: Cancer cluster investigations rarely receive significant public health resource allocations due to numerous inherent challenges and the limited success of past efforts. In 2008, a cluster of polycythemia vera, a rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. A multidisciplinary group of federal and state agencies, academic institutions, and local healthcare providers subsequently developed a multifaceted research portfolio designed to better understand the cause of the cluster. This research agenda represents a unique and important opportunity to demonstrate that cancer cluster investigations can produce desirable public health and scientific outcomes when necessary resources are available.
authors.affiliation: Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA 30341, USA. VSeaman@cdc.gov
authors.forename: Vincent
authors.initials: V
authors.lastname: Seaman
authors.forename: Steve M
authors.initials: SM
authors.lastname: Dearwent
authors.forename: Debra
authors.initials: D
authors.lastname: Gable
authors.forename: Brian
authors.initials: B
authors.lastname: Lewis
authors.forename: Susan
authors.initials: S
authors.lastname: Metcalf
authors.forename: Ken
authors.initials: K
authors.lastname: Orloff
authors.forename: Bruce
authors.initials: B
authors.lastname: Tierney
authors.forename: Jane
authors.initials: J
authors.lastname: Zhu
authors.forename: James
authors.initials: J
authors.lastname: Logue
authors.forename: David
authors.initials: D
authors.lastname: Marchetto
authors.forename: Stephen
authors.initials: S
authors.lastname: Ostroff
authors.forename: Ronald
authors.initials: R
authors.lastname: Hoffman
authors.forename: Mingjiang
authors.initials: M
authors.lastname: Xu
authors.forename: David
authors.initials: D
authors.lastname: Carey
authors.forename: Porat
authors.initials: P
authors.lastname: Erlich
authors.forename: Glenn
authors.initials: G
authors.lastname: Gerhard
authors.forename: Paul
authors.initials: P
authors.lastname: Roda
authors.forename: Joseph
authors.initials: J
authors.lastname: Iannuzzo
authors.forename: Robert
authors.initials: R
authors.lastname: Lewis
authors.forename: John
authors.initials: J
authors.lastname: Mellow
authors.forename: Linda
authors.initials: L
authors.lastname: Mulvihill
authors.forename: Zachary
authors.initials: Z
authors.lastname: Myles
authors.forename: Manxia
authors.initials: M
authors.lastname: Wu
authors.forename: Arthur
authors.initials: A
authors.lastname: Frank
authors.forename: Carol Ann
authors.initials: CA
authors.lastname: Gross-Davis
authors.forename: Judith
authors.initials: J
authors.lastname: Klotz
authors.forename: Adam
authors.initials: A
authors.lastname: Lynch
authors.forename: Joel
authors.initials: J
authors.lastname: Weissfeld
authors.forename: Rona
authors.initials: R
authors.lastname: Weinberg
authors.forename: Henry
authors.initials: H
authors.lastname: Cole
mesh_terms: D016000:Cluster Analysis; D004781:Environmental Exposure; D019337:Hematologic Neoplasms / Q000453:epidemiology*; D006801:Humans; D010414:Pennsylvania / Q000453:epidemiology; D011087:Polycythemia Vera / Q000453:epidemiology*