Targeting granulocyte apoptosis: mechanisms, models, and therapies.
The inflammatory process is a complex series of tightly controlled cellular and biochemical events initiated by the immune system, which has evolved to eliminate or contain infectious agents and to repair damaged tissue. Apoptosis is essential for the clearance of potentially injurious inflammatory cells, such as neutrophils, eosinophils, and basophils, and the subsequent efficient resolution of inflammation. In this review, we aim to cover key features of the granulocyte life-cycle ranging from their differentiation within the bone marrow to their maturation and ultimate clearance, with a focus on granulocyte apoptosis and macrophage efferocytosis. We further aim to discuss current and emerging models of inflammation and suggest novel ways of terminating or resolving deleterious inflammatory responses with a specific view to the translation of these strategies into fully realized, pro-resolution therapies.
Duffin
Rodger
R
MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. rodger.duffin@ed.ac.uk
Leitch
Andrew E
AE
Fox
Sarah
S
Haslett
Chris
C
Rossi
Adriano G
AG
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D018448:Models, Immunological; D010587:Phagocytosis / Q000276:immunology