Can chronic gastritis cause an increase in fecal calprotectin concentrations?
OBJECTIVE
To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.


METHODS
FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score (mild, moderate, marked). FFCs in relation to Helicobacter pylori (H. pylori) infection and proton pump inhibitor (PPI) use were also evaluated.


RESULTS
FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls. Among patients with chronic active gastritis (even marked), FCCs did not significantly differ according to activity score. No significant differences in FCCs were found when considering H. pylori, as well as when considering PPI chronic use.


CONCLUSIONS
FCCs were not significantly increased in subjects with chronic gastritis, even in those patients with a marked neutrophil infiltration.
Montalto
Massimo
M
Institute of Internal Medicine, Catholic University, Largo Gemelli 8, 00168 Roma, Italy. mmontalto@rm.unicatt.it
Gallo
Antonella
A
Ianiro
Gianluca
G
Santoro
Luca
L
D'Onofrio
Ferruccio
F
Ricci
Riccardo
R
Cammarota
Giovanni
G
Covino
Marcello
M
Vastola
Monica
M
Gasbarrini
Antonio
A
Gasbarrini
Giovanni
G
D000328:Adult; D000368:Aged; D015415:Biomarkers; D002908:Chronic Disease; D005243:Feces / Q000737:chemistry*; D005260:Female; D005756:Gastritis / Q000503:physiopathology*; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex