title: Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.
abstract: In this 13-week, open-label, randomized study of the anti-inflammatory salsalate versus usual care, there were no significant improvements in flow-mediated dilation of the brachial artery, endothelial activation, inflammation or coagulation markers, homeostasis model assessment of insulin resistance or lipoproteins with salsalate or between groups in virologically suppressed, HIV-infected adults on antiretrovirals. Tinnitus and transaminitis occurred frequently in the salsalate group. Dose reduction due to toxicities encountered and low level of inflammation may explain these results.
authors.affiliation: University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Corrilynn O
authors.initials: CO
authors.lastname: Hileman
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Carman
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Gripshover
authors.forename: Maryann
authors.initials: M
authors.lastname: O'Riordan
authors.forename: Norma J
authors.initials: NJ
authors.lastname: Storer
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Harrill
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: White
authors.forename: Grace A
authors.initials: GA
authors.lastname: McComsey
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D001916:Brachial Artery / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D012459:Salicylates / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; C014182:salicylsalicylic acid