title: [Circulating cell-free serum DNA: significance as a new biomarker for urological malignancies].
abstract: The presence of circulating cell-free DNA was demonstrated already in the 1940s. Improved detection methods have led to increased knowledge on cell-free DNA, and recent studies showed that most cancer patients have increased levels of cell-free DNA. Measurement of cell-free DNA allowed sensitive and specific discrimination between cancer patients and those with non-malignant diseases.
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsklinikum Bonn, Bonn, Deutschland. joerg.ellinger@ukb.uni-bonn.de
authors.forename: J
authors.initials: J
authors.lastname: Ellinger
authors.forename: A
authors.initials: A
authors.lastname: von Rücker
authors.forename: P J
authors.initials: PJ
authors.lastname: Bastian
authors.forename: S C
authors.initials: SC
authors.lastname: Müller
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002474:Cell-Free System; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics*; D003950:Diagnostic Techniques, Urological; D006801:Humans; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm