title: Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1.
abstract: The novel gene HA117 is a multidrug resistance (MDR) gene in all-trans retinoic acid resistance HL-60 cells. The transduction of adenovirus vectors encoding HA117 conferred breast cancer cell line 4T1 MDR not only to MRP1 substrate drugs but also to MRP1 non-substrate drugs and the MDR strength of HA117 was similar to that of multidrug resistance-associated protein-1 (MRP1) for MRP1 substrate, but HA117 had no daunorubicin-excretion function.
authors.affiliation: Laboratory of Oncology, Department of Surgery, Affiliated Children's Hospital, Chongqing Medical University, No.136, Zhongshan 2nd Road Yuzhong District, Chongqing, 86 400014, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhao
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Sun
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Li
authors.forename: Xianqing
authors.initials: X
authors.lastname: Jin
authors.forename: Youhua
authors.initials: Y
authors.lastname: Xu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Guo
authors.forename: Rui
authors.initials: R
authors.lastname: Liang
authors.forename: Xionghui
authors.initials: X
authors.lastname: Ding
authors.forename: Tingfu
authors.initials: T
authors.lastname: Chen
authors.forename: Siqi
authors.initials: S
authors.lastname: Wang
mesh_terms: D015153:Blotting, Western; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019450:Genes, MDR / Q000235:genetics*; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014161:Transduction, Genetic
chemical_list: D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1