Copper and ceruloplasmin abnormalities in Alzheimer's disease.
The idea that copper may play a role in the pathogenesis of Alzheimer's disease is gaining momentum. Serum copper and ceruloplasmin were measured by both enzymatic (eCp) and immunologic (iCp) methods in 28 patients with Alzheimer's disease and 29 age-matched controls. ''Free copper'' was determined by subtracting copper accounted for in the eCp assay from total serum copper. Percentage free copper, that is the proportion of serum copper not bound to ceruloplasmin, was significantly elevated in patients with Alzheimer's compared to controls. There was significantly more ''defective'' ceruloplasmin, which is apoceruloplamin lacking its copper, in Alzheimer's disease than in normal controls. This abnormality may precede the clinical onset of the disease and help predict risk of disease onset. Increased exposure to environmental copper (eg, the spread of copper plumbing and the use of copper in supplements) and/or defective ceruloplasmin function may play a role in the current epidemic of Alzheimer's disease.
Brewer
George J
GJ
Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA. brewergj@umich.edu
Kanzer
Steve H
SH
Zimmerman
Earl A
EA
Celmins
Dzintra F
DF
Heckman
Susan M
SM
Dick
Robert
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism*; D001059:Apoproteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002570:Ceruloplasmin / Q000276:immunology / Q000378:metabolism*; D003300:Copper / Q000097:blood*; D004789:Enzyme Activation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors
D001059:Apoproteins; D015415:Biomarkers; C006612:apoceruloplasmin; D003300:Copper; D002570:Ceruloplasmin