title: Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.
abstract: OBJECTIVE
  To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population.
  
  
  METHODS
  We enrolled 200 patients with AF (mean age: 67 +/- 13 years) and 158 controls (mean age: 63 +/- 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods.
  
  
  RESULTS
  The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01).
  
  
  CONCLUSIONS
  In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF.
authors.affiliation: Department of Internal Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC. kuntai.lee@msa.hinet.net
authors.forename: Kun-Tai
authors.initials: KT
authors.lastname: Lee
authors.forename: Hi-Yin
authors.initials: HY
authors.lastname: Yeh
authors.forename: Chung-Po
authors.initials: CP
authors.lastname: Tung
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Chu
authors.forename: Kai-Hung
authors.initials: KH
authors.lastname: Cheng
authors.forename: Wei-Chung
authors.initials: WC
authors.lastname: Tsai
authors.forename: Ye-Hsu
authors.initials: YH
authors.lastname: Lu
authors.forename: Jan-Gowth
authors.initials: JG
authors.lastname: Chang
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Sheu
authors.forename: Wen-Ter
authors.initials: WT
authors.lastname: Lai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D017931:DNA Primers