[Autogenous platelet-rich plasma gel with acellular xenogeneic dermal matrix for treatment of deep II degree burns].
OBJECTIVE
To investigate the effectiveness of autogenous platelet-rich plasma (PRP) gel with acellular xenogeneic dermal matrix in the treatment of deep II degree burns.


METHODS
From January 2007 to December 2009, 30 cases of deep II degree burns were treated. There were 19 males and 11 females with an average age of 42.5 years (range, 32-57 years). The burn area was 10% to 48% of total body surface area. The time from burn to hospitalization was 30 minutes to 8 hours. All patients were treated with tangential excision surgery, one side of the wounds were covered with autogenous PRP gel and acellular xenogeneic dermal matrix (PRP group), the other side of the wounds were covered with acellular xenogeneic dermal matrix only (control group). The healing rate, healing time, infection condition, and scar formation were observed.


RESULTS
At 7 days after operation, the infection rate in PRP group (6.7%, 2/30) was significantly lower than that in control group (16.7%, 5/30, P < 0.05). The healing times were (18 +/- 4) days and (22 +/- 4) days respectively in PRP group and control group, showing significant difference (P < 0.05). The healing rates at 14 days and 21 days were 75% +/- 7% and 88% +/- 5% in PRP group, were 62% +/- 15% and 73% +/- 7% in control group, showing significant difference (P < 0.05). RPR group was superior to control group in elasticity, color, appearance, softness, scar formation, and healing quality.


CONCLUSIONS
Autogenous PRP gel with acellular xenogeneic dermal matrix can accelerate the wound healing of deep II degree burns as well as alleviate the scar proliferation.
Hao
Tianzhi
T
Department of Burn and Plastic Surgery, General Hospital of Beijing Command, Beijing, 100125, P.R.China. htz.jn@126.com
Zhu
Jingmin
J
Hu
Wenbo
W
Zhang
Hua
H
Gao
Zhenhui
Z
Wen
Xuehui
X
Zhou
Zhi
Z
Lu
Gang
G
Liu
Jingjie
J
Li
Wen
W
D000328:Adult; D002056:Burns / Q000628:therapy*; D020405:Dermis / Q000637:transplantation*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014945:Wound Healing
D005782:Gels