Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
Antimicrobial susceptibilities of 233 gram-positive and 180 gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 microg/ml. One bis-indole, MBX 1162, exhibited potent activity against all gram-negative strains, with MIC(90) values of 0.12 to 4 microg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.
Butler
Michelle M
MM
Microbiotix, Inc., One Innovation Drive, Worcester, MA 01605, USA. mbutler@microbiotix.com
Williams
John D
JD
Peet
Norton P
NP
Moir
Donald T
DT
Panchal
Rekha G
RG
Bavari
Sina
S
Shinabarger
Dean L
DL
Bowlin
Terry L
TL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D007211:Indoles; C030374:indole