IL-17 increased in the third trimester in healthy women with term labor.
BACKGROUND
The function, peripheral blood expression, and physiologic importance of IL-17 is not well established. Detection of IL-17 in sera and plasma samples from patients with pre-eclampsia has been reported with inconsistent results. To establish the l levels of the IL-17 at peripheral level, we studied prospectively a cohort of 13 healthy pregnant women.


OBJECTIVE
To evaluate the changes in serum levels of IL-17 in healthy pregnant women in a prospective cohort.


METHODS
Thirteen healthy pregnant women were prospectively followed to evaluate serum levels of IL-17. Each patient was evaluated at each trimester. IL-17 levels were measured by ELISA. The statistical analysis was done using repeated measures anova and Bonferroni's multiple comparison test.


RESULTS
IL-17 levels were significantly increased from first trimester with a mean of 14.61 up to 31.78 pg/mL at third trimester (P < 0.05), but when detectable, they were almost identical range in all trimesters.


CONCLUSIONS
We propose that IL-17 levels in healthy women are present with very similar range levels during the whole pregnancy but the average is increased during the third trimester maybe as a part of the complex network of cytokines as a result of implantation, fetal development, and labor process itself.
Martínez-García
Erika A
EA
Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México.
Chávez-Robles
Bernardo
B
Sánchez-Hernández
Pedro E
PE
Núñez-Atahualpa
Lourdes
L
Martín-Máquez
Beatriz T
BT
Muñoz-Gómez
Andrea
A
González-López
Laura
L
Gámez-Nava
Jorge I
JI
Salazar-Páramo
Mario
M
Dávalos-Rodríguez
Ingrid
I
Petri
Marcelo H
MH
Zúñiga-Tamayo
Diego
D
Vargas-Ramírez
Raúl
R
Vázquez-Del Mercado
Mónica
M
D000328:Adult; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood*; D047929:Term Birth; D015854:Up-Regulation; D055815:Young Adult
D020381:Interleukin-17