Serum levels of 20K-hGH and 22K-hGH isoforms in acromegalic patients.
The diagnosis and treatment decisions in acromegaly depend on the measurement of growth hormone (GH) and insulin-like growth factor I (IGF-I) levels. The occurrence of different GH isoforms in the serum, mainly 22K-hGH and 20K-hGH, is a source of heterogeneity of GH results measured by different immunoassays. Since it has been previously reported that the proportion of 20K-hGH is increased in patients with active acromegaly, it might be useful to know the GH isoforms' pattern not to underdiagnose or undertreat acromegalic patients.
Lima
Giovanna A B
GAB
Gadelha
Mônica R
MR
Strasburger
Christian J
CJ
Wu
Zida
Z
D000172:Acromegaly / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D010446:Peptide Fragments / Q000097:blood*; D020033:Protein Isoforms
D010446:Peptide Fragments; D020033:Protein Isoforms; C039519:somatotropin 20K; D019382:Human Growth Hormone