Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bio-assays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyanoenones of boswellic acid and glycyrrhetinic acid.
Subba Rao
G S R
GS
Department of Organic chemistry, Indian Institute of Science, Bangalore 560 012, India.
Kondaiah
Paturu
P
Singh
Sanjay K
SK
Ravanan
Palaniyandi
P
Sporn
Michael B
MB