title: Expression and regulation in the brain of the chemokine CCL27 gene locus.
abstract: The chemokine CCL27 has chemoattractant properties for memory T cells and has been implicated in skin allergic reactions. The present study reports the expression in the brain of two CCL27 splice variants localized in the cerebral cortex and limbic regions. CCL27-like immunoreactivity was identified mainly in neurons. Variant 1 was found elevated in the olfactory bulbs during allergic inflammation induced by intranasal challenge with allergen. This was accompanied by the presence of T cells in the olfactory bulbs. Intranasal administration of neutralizing antibodies against CCL27 reduced the presence of T cells in the olfactory bulbs suggesting a function in T cell activity in the brain.
authors.affiliation: Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201-1549, USA.
authors.forename: Chad
authors.initials: C
authors.lastname: Gunsolly
authors.forename: James D
authors.initials: JD
authors.lastname: Nicholson
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Listwak
authors.forename: Dolena
authors.initials: D
authors.lastname: Ledee
authors.forename: Peggy
authors.initials: P
authors.lastname: Zelenka
authors.forename: Daniela
authors.initials: D
authors.lastname: Verthelyi
authors.forename: Svetlana
authors.initials: S
authors.lastname: Chapoval
authors.forename: Achsah
authors.initials: A
authors.lastname: Keegan
authors.forename: Leonardo H
authors.initials: LH
authors.lastname: Tonelli
mesh_terms: D000418:Albumins / Q000009:adverse effects / Q000276:immunology; D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D017252:CD3 Complex / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D054425:Chemokine CCL27 / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology*; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D000418:Albumins; D017252:CD3 Complex; D054425:Chemokine CCL27; D020033:Protein Isoforms; D012333:RNA, Messenger