Reference serum cystatin C levels in Japanese children.
BACKGROUND
Single measurements of serum cystatin C (cysC) concentration have generally been used to determine glomerular filtration rate (GFR) in adults. Since GFR varies to some extent among children, we attempted to determine reference serum cysC concentrations for Japanese children.


METHODS
Serum cysC concentrations were determined by a latex particle-enhanced turbidimetric immunoassay in children who did not present with kidney disease or infectious disease, and the relationship between age and serum cysC level was assessed.


RESULTS
We found that reference serum cysC levels gradually decreased during the first year after birth, thereafter becoming constant. Mean serum cysC concentration in children aged 1 year (0.76 ± 0.10 mg/L) was slightly higher than in children aged ≥2 years (0.70 ± 0.09 mg/L).


CONCLUSIONS
Our reference values will be applicable for screening renal function in Japanese children.
Uemura
Osamu
O
Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, Obu, Aichi, 474-8710, Japan. o_uemura@hkg.odn.ne.jp
Ushijima
Katsumi
K
Nagai
Takuhito
T
Yamada
Takuji
T
Hayakawa
Hideki
H
Nabeta
Yayoi
Y
Shinkai
Yoshiko
Y
Koike
Kouichi
K
Kuwabara
Masaki
M
D000293:Adolescent; D000375:Aging / Q000097:blood; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007677:Kidney Function Tests / Q000379:methods / Q000592:standards; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000592:standards; D012016:Reference Values
D055316:Cystatin C