Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.
Epidemiological research provides strong evidence for a link between repetitive work (RW) and the development of chronic trapezius myalgia (TM). The aims were to further elucidate if an accumulation of sensitising substances or impaired oxygenation is evident in painful muscles during RW. Females with TM (n = 14) were studied during rest, 30 minutes RW and 60 minutes recovery. Microdialysate samples were obtained to determine changes in intramuscular microdialysate (IMMD) [glutamate], [PGE(2)], [lactate], and [pyruvate] (i.e., [concentration]) relative to work. Muscle oxygenation (%StO(2)) was assessed using near-infrared spectroscopy. During work, all investigated substances, except PGE(2), increased significantly: [glutamate] (54%, P < .0001), [lactate] (26%, P < .005), [pyruvate] (19%, P < .0001), while the %StO(2) decreased (P < .05). During recovery [PGE(2)] decreased (P < .005), [lactate] remained increased (P < .001), [pyruvate] increased progressively (P < .0001), and %StO(2) had returned to baseline. Changes in substance concentrations and oxygenation in response to work indicate normal increase in metabolism but no ongoing inflammation in subjects with TM.
Flodgren
Gerd M
GM
Centre for Musculoskeletal Research, University of Gävle, Umeå, Sweden. gerd.flodgren@ncl.ac.uk
Crenshaw
Albert G
AG
Hellström
Fredrik
F
Fahlström
Martin
M
D050154:Adiposity / Q000502:physiology; D000328:Adult; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D017551:Microdialysis / Q000379:methods*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism; D010146:Pain / Q000150:complications; D005082:Physical Exertion / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D016474:Weight-Bearing
D019344:Lactic Acid; D018698:Glutamic Acid; D010100:Oxygen