title: LuxR-type quorum-sensing regulators that are detached from common scents.
abstract: The ability of LuxR-type proteins to regulate transcription is controlled by bacterial pheromones, N-acylhomoserine lactones (AHLs). Most LuxR-family proteins require their cognate AHLs for activity, and at least some of them require AHLs for folding and protease resistance. However, a few members of this family are able to fold, dimerize, bind DNA, and regulate transcription in the absence of AHLs; moreover, these proteins are antagonized by their cognate AHLs. Complexes between some of these proteins and their DNA binding sites are disrupted by AHLs in vitro. All such proteins are fairly closely related within the larger LuxR family, indicating that they share a relatively recent common ancestor. The 3' ends of the genes encoding these receptors invariably overlap with the 3' ends of the cognate AHL synthase genes, suggesting additional antagonism at the level of mRNA synthesis, stability or translation.
authors.affiliation: Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Ching-Sung
authors.initials: CS
authors.lastname: Tsai
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Winans
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D015964:Gene Expression Regulation, Bacterial; D023061:Gene Order; D053038:Quorum Sensing; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013312:Stress, Physiological; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D054742:Acyl-Butyrolactones; D012097:Repressor Proteins; D015534:Trans-Activators; C064778:LuxR autoinducer binding proteins