title: Hydrogen peroxide vapor decontamination of an intensive care unit to remove environmental reservoirs of multidrug-resistant gram-negative rods during an outbreak.
abstract: Multidrug-resistant gram-negative rods (MDR-GNR) are an increasing cause for concern in intensive care units (ICUs). We used hydrogen peroxide vapor (HPV) to decontaminate our entire ICU in an attempt to eradicate undetected environmental contamination during outbreaks of MDR-GNR. Surface sampling identified GNR, including MDR strains, on 10 (48%) of 21 areas cultured after intensive cleaning but before decontamination with HPV, and on no areas after HPV. No new cases of Acinetobacter were identified for approximately 3 months after HPV.
authors.affiliation: Bioquell (UK) Ltd., 52 Royce Close, West Portway, Andover, UK. jon.otter@bioquell.com
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Otter
authors.forename: Saber
authors.initials: S
authors.lastname: Yezli
authors.forename: Marinus A
authors.initials: MA
authors.lastname: Schouten
authors.forename: Arthur R H
authors.initials: AR
authors.lastname: van Zanten
authors.forename: Greetje
authors.initials: G
authors.lastname: Houmes-Zielman
authors.forename: Maria K E
authors.initials: MK
authors.lastname: Nohlmans-Paulssen
mesh_terms: D003428:Cross Infection / Q000453:epidemiology*; D003666:Decontamination / Q000379:methods*; D004202:Disinfectants / Q000494:pharmacology; D004203:Disinfection / Q000379:methods*; D024901:Drug Resistance, Multiple, Bacterial; D004783:Environmental Microbiology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007362:Intensive Care Units; D014835:Volatilization
chemical_list: D004202:Disinfectants; D006861:Hydrogen Peroxide