title: Dengue.
abstract: BACKGROUND
  Dengue is a vector-borne viral infection that endangers an estimated 2.5 billion people. Disease caused by dengue ranges from a relatively minor febrile illness to a life-threatening condition characterized by extensive capillary leak. A greater understanding of dengue has the potential to improve both the clinical management of individual cases and the control of the disease.
  
  
  METHODS
  We searched the available literature using PubMed, Embase and Web of Science for relevant articles and abstracts.
  
  
  RESULTS
  Addressing our gaps in the understanding of disease pathogenesis and improving our knowledge of dengue virus biology are necessary in order to develop tools to effectively control, diagnose and treat the disease.
  
  
  RESULTS
  The pathogenesis of dengue is multifactorial and depends on both host and virus factors. A more integrated understanding of disease pathogenesis is necessary.
  
  
  CONCLUSIONS
  There are many questions related to disease pathogenesis, development of diagnostics, drug and vaccine development and individual case management that need addressing if the disease is to be successfully tackled.
authors.affiliation: London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: James
authors.initials: J
authors.lastname: Whitehorn
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
mesh_terms: D003715:Dengue / Q000473:pathology / Q000517:prevention & control* / Q000635:transmission; D053059:Dengue Vaccines / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans
chemical_list: D053059:Dengue Vaccines