Review of heart-lung transplantation at Stanford.
Long-term survival after heart-lung transplantation was first achieved in 1981 at Stanford and a total of 217 heart-lung transplantations had been performed by June 2008. This review summarizes Stanford's cumulative experience with heart-lung transplantation, demonstrates the progress that has been made, and discusses past and persistent problems. Diagnostic tools and treatment options for infectious diseases and rejection have changed and patient survival markedly improved over the almost three decades. Eight patients lived longer than 20 years. Further options to treat infections and strategies to control bronchiolitis obliterans syndrome, the main causes of early and long-term mortality, respectively, are required to achieve routine long-term survival.
Deuse
Tobias
T
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA.
Sista
Ramachandra
R
Weill
David
D
Tyan
Dolly
D
Haddad
Francois
F
Dhillon
Gundeep
G
Robbins
Robert C
RC
Reitz
Bruce A
BA
D000046:Academic Medical Centers; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D016041:Heart-Lung Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D055815:Young Adult