Synthesis and characterization of quaternized beta-chitin.
Water-soluble 2'-O-hydroxypropyltrimethylammoniumchitin chloride (2'-O-HTACCt) was prepared directly from beta-chitin and 3-chloro-2-hydroxypropyltrimethylammonium chloride (CTA) in basic medium. The effect of alkali concentration, reaction temperature, reaction time, and dosage of CTA on yield and degree of substitution (DS) of 2'-O-HTACCt were studied. These quaternized chitin derivatives were characterized by FTIR and (1)H NMR spectroscopy, conductometric titration, and elemental analysis methods. Research results indicate that beta-chitin can react directly with CTA to produce a water-soluble 2'-O-HTACCt derivative with a high DS. The optimal preparation conditions were determined to be 35-40 wt% (aq NaOH), 40 degrees C (reaction temperature), 6h (reaction time), and 4 (molar ratio of CTA to beta-chitin unit).
Chen
Qunying
Q
Faculty of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen, PR China.
Wu
Yiguang
Y
Pu
Yitao
Y
Zheng
Zongkun
Z
Shi
Chunzhi
C
Huang
Xinzheng
X
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002686:Chitin / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D020005:Propanols / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
D000890:Anti-Infective Agents; D020005:Propanols; D000644:Quaternary Ammonium Compounds; D014867:Water; D002686:Chitin; C496948:(3-chloro-2-hydroxypropyl)trimethylammonium chloride