title: Kinetics of aqueous chlorination of some pharmaceuticals and their elimination from water matrices.
abstract: Apparent rate constants for the reactions of four selected pharmaceutical compounds (metoprolol, naproxen, amoxicillin, and phenacetin) with chlorine in ultra-pure (UP) water were determined as a function of the pH. It was found that amoxicillin (in the whole pH range 3-12), and naproxen (in the low pH range 2-4) presented high reaction rates, while naproxen (in the pH range 5-9), and phenacetin and metoprolol (in the pH range 2.5-12 for phenacetin, and 3-10 for metoprolol) followed intermediate and slow reaction rates. A mechanism is proposed for the chlorination reaction, which allowed the evaluation of the intrinsic rate constants for the elementary reactions of the ionized and un-ionized species of each selected pharmaceutical with chlorine. An excellent agreement is obtained between experimental and calculated rate constants by this mechanism.The elimination of these substances in several waters (a groundwater, a surface water from a public reservoir, and two effluents from municipal wastewater treatment plants) was also investigated at neutral pH. The efficiency of the chlorination process with respect to the pharmaceuticals elimination and the formation THMs was also established. It is generally observed that the increasing presence of organic and inorganic matter in the water matrices demand more oxidant agent (chlorine), and therefore, less chlorine is available for the oxidation of these compounds. Finally, half-life times and oxidant exposures (CT) required for the removal of 99% of the four pharmaceuticals are also evaluated. These parameters are useful for the establishment of safety chlorine doses in oxidation or disinfection stages of pharmaceuticals in treatment plants.
authors.affiliation: Universidad de Extremadura, Departamento de Ingeniería Química y Química Física, 06006 Badajoz, Spain. jlacero@unex.es
authors.forename: Juan L
authors.initials: JL
authors.lastname: Acero
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Benitez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Real
authors.forename: Gloria
authors.initials: G
authors.lastname: Roldan
mesh_terms: D000658:Amoxicillin / Q000737:chemistry / Q000302:isolation & purification; D005618:Fresh Water / Q000737:chemistry*; D054879:Halogenation; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008790:Metoprolol / Q000737:chemistry / Q000302:isolation & purification; D009288:Naproxen / Q000737:chemistry / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification; D010615:Phenacetin / Q000737:chemistry / Q000302:isolation & purification; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000302:isolation & purification; D018508:Water Purification / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical; D009288:Naproxen; D000658:Amoxicillin; D010615:Phenacetin; D008790:Metoprolol