title: Structure of autophagy-related protein Atg8 from the silkworm Bombyx mori.
abstract: Autophagy-related protein Atg8 is ubiquitous in all eukaryotes. It is involved in the Atg8-PE ubiquitin-like conjugation system, which is essential for autophagosome formation. The structures of Atg8 from different species are very similar and share a ubiquitin-fold domain at the C-terminus. In the 2.40 A crystal structure of Atg8 from the silkworm Bombyx mori reported here, the ubiquitin fold at the C-terminus is preceded by two additional helices at the N-terminus.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Hu
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Yan Bin
authors.initials: YB
authors.lastname: Teng
authors.forename: Hai Xi
authors.initials: HX
authors.lastname: Hu
authors.forename: Wei Fang
authors.initials: WF
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001343:Autophagy; D012831:Bombyx / Q000737:chemistry* / Q000166:cytology; D018360:Crystallography, X-Ray; D019476:Insect Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017510:Protein Folding; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D019476:Insect Proteins