title: [Macrophage activation syndrome as the presenting feature of a Hodgkin's lymphoma in an elderly patient].
abstract: Macrophage activation syndrome (MAS) is a rare immunological disorder, rapidly life-threatening in the absence of specific treatment. Malignant lymphoma is common cause of MAS, but Hodgkin's lymphoma has been rarely associated with MAS. We report a 79-year-old man who presented a MAS as the presenting feature of Hodgkin's lymphoma, with a rapidly fatal outcome. We discuss the usefulness of sCD25 and interleukine 18 assays when diagnosis is difficult to obtain. We also review the literature data related to Hodgkin's lymphoma-associated MAS.
authors.affiliation: Fédération des laboratoires, HIA Sainte-Anne, 2, boulevard Sainte-Anne, BP 20545, 83041 Toulon cedex 9, France. christophe.martinaud@inserm.fr
authors.forename: C
authors.initials: C
authors.lastname: Martinaud
authors.forename: J-M
authors.initials: JM
authors.lastname: Cournac
authors.forename: S
authors.initials: S
authors.lastname: Pons
authors.forename: T
authors.initials: T
authors.lastname: Gaillard
authors.forename: C
authors.initials: C
authors.lastname: Darles
authors.forename: J-P
authors.initials: JP
authors.lastname: de Jaureguiberry
authors.forename: P
authors.initials: P
authors.lastname: Brisou
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D055501:Macrophage Activation Syndrome / Q000209:etiology*; D008297:Male