Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus.
Acute experiments on anesthetized laboratory rats were performed to study the effects microinjections of 10(-4) M leptin into the solitary tract nucleus on the extent of the Hering-Breuer inflation reflex in ventilatory reactions to hypercapnia. Local administration of leptin into this area led to inhibition of the Hering-Breuer reflex. The extent of ventilatory responses to hypercapnia, conversely, increased, which may provide evidence that leptin has a modulatory influence on central chemoreceptors. These physiological mechanisms of action probably play a leading role in mediating the stimulatory respiratory effects of leptin at the level of the solitary tract nucleus.
Inyushkina
E M
EM
Samara State University, 1 Academician Pavlov St., 443016, Samara, Russia.
Merkulova
N A
NA
Inyushkin
A N
AN
D000818:Animals; D004576:Electromyography; D005260:Female; D006935:Hypercapnia / Q000503:physiopathology; D020738:Leptin / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D008845:Microinjections; D051381:Rats; D012026:Reflex, Stretch / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects / Q000502:physiology*; D017552:Solitary Nucleus / Q000187:drug effects / Q000502:physiology*
D020738:Leptin