title: The effects of lazaroid U-74389G in a rat sepsis model.
abstract: OBJECTIVE
  To examine the protective effects of a lazaroid, 21-aminosteroid U-74389G, in a rat septic shock model.
  
  
  METHODS
  Male Sprague-Dawley rats (n = 60) aged 6-8 months.
  
  
  METHODS
  Groups were exposed to 500 cGy radiation followed by E. coli inoculation, and either placebo or lazaroid injection (10 mg/kg intraperitoneal) 5 days after irradiation.
  
  
  METHODS
  Hemodynamic measurements, arterial blood gases, serum lactate, total antioxidative capacity, and cytokine levels were measured at specific time intervals.
  
  
  RESULTS
  Treatment with the lazaroid U-74389G maintained cardiac output and mean aortic pressure. Lazaroid treatment also prevented the increase in serum lactate seen in placebo-treated rats. Cytokine serum levels in lazaroid-treated rats were not significantly different from those in placebo-treated rats at any time point.
  
  
  CONCLUSIONS
  Lazaroid treatment of E. coli-inoculated septic animals lessens the hemodynamic deterioration seen in sepsis.
authors.affiliation: Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung City, Taiwan.
authors.forename: Yun-Te
authors.initials: YT
authors.lastname: Chang
authors.forename: Shue-Ren
authors.initials: SR
authors.lastname: Wann
authors.forename: Kai-Hseng
authors.initials: KH
authors.lastname: Hsieh
authors.forename: Yung-Ching
authors.initials: YC
authors.lastname: Liu
authors.forename: Ching-Hsiung
authors.initials: CH
authors.lastname: Chang
authors.forename: Mu-Shun
authors.initials: MS
authors.lastname: Huang
authors.forename: Chun-I
authors.initials: CI
authors.lastname: Huang
authors.forename: Hong-Tai
authors.initials: HT
authors.lastname: Chang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000276:immunology / Q000472:pathogenicity; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010919:Placebos; D011281:Pregnatrienes / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D014965:X-Rays
chemical_list: D007166:Immunosuppressive Agents; D010919:Placebos; D011281:Pregnatrienes; C074965:U 74389F