Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro.
In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-beta-D: -glucopyranoside (2), apigenin-7-O-(6''-O-acetyl)-beta-D: -glucopyranoside (3), luteolin (4), luteolin-7-O-beta-D: -glucopyranoside (5), luteolin-7-O-(6''-O-acetyl)-beta-D: -glucopyranoside (6), isorhamnetin-3-Oneohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-beta-D: -glucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), beta-sitosterol glucoside (14), and alpha-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.
Jang
Dae Sik
DS
Diabetic Complications Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea.
Lee
Yun Mi
YM
Jeong
Il Ha
IH
Kim
Jin Sook
JS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000150:complications / Q000517:prevention & control; D048909:Diabetes Complications / Q000517:prevention & control; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005136:Eye Proteins / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006031:Glycosylation / Q000187:drug effects; D007908:Lens, Crystalline / Q000201:enzymology*; D008297:Male; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D031238:Platycodon / Q000737:chemistry*; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012710:Serum Albumin, Bovine / Q000737:chemistry
D004791:Enzyme Inhibitors; D005136:Eye Proteins; D005419:Flavonoids; D017127:Glycation End Products, Advanced; D010636:Phenols; D010936:Plant Extracts; C472707:caffeoylquinic acid; D011801:Quinic Acid; D012710:Serum Albumin, Bovine; D000449:Aldehyde Reductase