title: History of preeclampsia is not associated with an increased risk of thyroid dysfunction.
abstract: OBJECTIVE
  We evaluated the thyroid function in women with a history of preeclampsia and/or HELLP syndrome at least 2 years after delivery.
  
  
  METHODS
  Observational retrospective study.
  
  
  METHODS
  University Medical Center Groningen, The Netherlands.
  
  
  METHODS
  Women with a history of preeclampsia and/or HELLP syndrome (n = 310) or uncomplicated pregnancies (n = 363), between January 1990 and February 2003.
  
  
  METHODS
  Measurement of serum thyroid stimulating hormone (TSH) levels and antibodies to thyroid peroxidase and the use of a questionnaire about relevant history and family history of auto-immune diseases related to thyroid disease.
  
  
  METHODS
  Prevalence of primary thyroid dysfunction and antibodies to thyroid peroxidase.
  
  
  RESULTS
  Mean serum TSH values were not significantly different between the preeclampsia and control group (1.62 vs. 1.80 mU/l). The percentage of women who have (have had) hypothyroidism and hyperthyroidism, respectively, did not differ significantly between the preeclampsia and the control group (3.3 vs. 6.1% and 10.0 vs. 7.7%). Furthermore the prevalence of antibodies to thyroid peroxidase was not significantly different (6.1 vs. 7.7%).
  
  
  CONCLUSIONS
  Preeclampsia and/or HELLP syndrome are not associated with an increased risk of thyroid dysfunction in later life.
authors.affiliation: Department of Obstetrics and Gynecology, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
authors.forename: Ruth R
authors.initials: RR
authors.lastname: Dekker
authors.forename: Bram M
authors.initials: BM
authors.lastname: Jochemsen
authors.forename: Maria G
authors.initials: MG
authors.lastname: van Pampus
authors.forename: Job G
authors.initials: JG
authors.lastname: Santema
authors.forename: Caroline
authors.initials: C
authors.lastname: Roozendaal
authors.forename: Henk
authors.initials: H
authors.lastname: Groen
authors.forename: Thera P
authors.initials: TP
authors.lastname: Links
authors.forename: Jasper J
authors.initials: JJ
authors.lastname: van Doormaal
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D017359:HELLP Syndrome / Q000453:epidemiology*; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology*; D007037:Hypothyroidism / Q000453:epidemiology*; D007453:Iodide Peroxidase / Q000276:immunology; D009426:Netherlands / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011795:Surveys and Questionnaires; D013972:Thyrotropin / Q000097:blood
chemical_list: D000906:Antibodies; D013972:Thyrotropin; D007453:Iodide Peroxidase