The DUBle life of polycomb complexes.
Many Polycomb group (PcG) proteins assemble into complexes containing histone-modifying enzymes that act in concert to control developmental regulators. In a recent study in Nature, Scheuermann et al. report the identification of a PcG complex with histone H2A-specific deubiquitinase activity that may be a key player in PcG-target gene regulation.
Schuettengruber
Bernd
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Institut de Génétique Humaine, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France.
Cavalli
Giacomo
G