title: Interactions between tobamovirus replication proteins and cellular factors: their impacts on virus multiplication.
abstract: Most viral gene products function inside cells in the presence of various host proteins, nucleic acids, and lipids. Thus, viral gene products come into direct contact with these molecules. The replication proteins of tobamovirus participate not only in viral genome replication but also in counterdefense mechanisms against RNA silencing and other plant defense systems. Accumulating evidence indicates that these functions are carried out through interactions with specific host components. Interactions with some cellular factors, however, are inhibitory to virus multiplication and contribute to host range restriction of tobamovirus. The interactions that have positive and negative impacts on virus multiplication should have been maintained and lost, respectively, during adaptation of the viruses to their respective natural hosts. This review lists the host factors that interact with the replication proteins of tobamovirus and discusses how they influence multiplication of the virus.
authors.affiliation: Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba 305-8602, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Nishikiori
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishikawa
mesh_terms: D054884:Host-Pathogen Interactions; D059828:Plant Cells; D010935:Plant Diseases / Q000821:virology; D010944:Plants / Q000821:virology*; D017898:Tobamovirus / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology*
chemical_list: D014764:Viral Proteins