[Clinical factors influencing liver stiffness as measured by transient elastography (Fibroscan) in patients with chronic liver disease].
OBJECTIVE
Transient elastography as performed using the Fibroscan is a useful noninvasive method for evaluating hepatic fibrosis. However, recent studies have found that liver stiffness measurement (LSM) values are inappropriately elevated in acute hepatitis or in the acute flare state of chronic hepatitis, suggesting that the LSM value obtained by the Fibroscan is not a reliable marker for fibrosis. We retrospectively evaluated the clinical factors influencing the LSM value obtained using transient elastography as performed using the Fibroscan in patients with chronic liver disease.


METHODS
A total of 298 patients who were followed in Kungpook National University Hospital from November 2007 to May 2008 due to previously established liver cirrhosis or chronic liver disease were investigated using the Fibroscan, laboratory test, ultrasound, and/or abdominal computed tomography.


RESULTS
The 298 patients were aged 47.8+/-12.9 years (mean+/-SD). The cut-off value for a diagnosis of liver cirrhosis was 12.5 kPa (as used in previous studies). Thirty-six patients (15%) and 202 patients (85%) with chronic liver disease without clinical manifestation of cirrhosis had LSMs of >12.5 kPa and <12.5 kPa, respectively. Multivariate analysis revealed that LSM values were unusually increased in patients with chronic liver disease who were older (P=0.007) or who had increased gamma glutamyltranspeptidase (GGT) (P=0.022), decreased albumin (P=0.015), or increased total bilirubin (P=0.009).


CONCLUSIONS
This study reveals that age, GGT, and albumin are clinical factors influencing LSM values. This reinforces the need to interpret LSM values in the context of a defined diagnosis, biochemical data, radiologic examination, and other clinical findings.
Bae
Rack Cheon
RC
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Cho
Han Jin
HJ
Oh
Jong Taek
JT
Lee
Eung Kap
EK
Heo
Jun
J
Shin
Keun Young
KY
Park
Soo Young
SY
Jeong
Min Kyu
MK
Jeon
Seong Woo
SW
Cho
Chang Min
CM
Tak
Won Young
WY
Kweon
Young Oh
YO
D000328:Adult; D000367:Age Factors; D001663:Bilirubin / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D054459:Elasticity Imaging Techniques; D005260:Female; D006505:Hepatitis / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D015415:Biomarkers; D012709:Serum Albumin; D005723:gamma-Glutamyltransferase; D001663:Bilirubin