Serum homocysteine and asymmetric dimethylarginine levels in patients with premature ovarian failure: a prospective controlled study.
OBJECTIVE
To investigate serum homocysteine and asymmetric dimethylarginine (ADMA) levels in patients with premature ovarian failure (POF).


METHODS
A total of 69 women, 32 with POF and 37 apparently healthy women were included in the study. Fasting blood samples were drawn to measure serum homocysteine and ADMA levels using ELISA method.


RESULTS
The study and control group had a mean age of 37.3 + 2.6, 37.5 + 2.5 years; a mean homocysteine level of 13.54 + 5.19, 12.71 + 3.99 mmol/l and a mean ADMA level of 1.32 + 0.27, 1.26 + 0.36 mmol/l, respectively. There were no statistically significant differences between the two groups in terms of homocysteine and ADMA levels (with p values of 0.465 and 0.423, respectively). A negative significant correlation was found between estradiol and ADMA (p <0.05).


CONCLUSIONS
Homocysteine and ADMA levels did not change in comparison with the control group, which suggests that estrogen deficiency in patients with POF does not have any effect on homocysteine and asymmetric dimethylarginine levels.
Gulhan
Ibrahim
I
Department of Obstetrics and Gynecology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey. drigulhan@yahoo.com
Bozkaya
Giray
G
Bilgir
Ferda
F
Kebapcilar
Levent
L
Bilgir
Oktay
O
Kavrut
Mustecep
M
Dogan
Erbil
E
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016649:Primary Ovarian Insufficiency / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index
C487735:dimethylarginine; D006710:Homocysteine; D004958:Estradiol; D001120:Arginine