[Macrophage activation syndrome as the presenting feature of a Hodgkin's lymphoma in an elderly patient].
Macrophage activation syndrome (MAS) is a rare immunological disorder, rapidly life-threatening in the absence of specific treatment. Malignant lymphoma is common cause of MAS, but Hodgkin's lymphoma has been rarely associated with MAS. We report a 79-year-old man who presented a MAS as the presenting feature of Hodgkin's lymphoma, with a rapidly fatal outcome. We discuss the usefulness of sCD25 and interleukine 18 assays when diagnosis is difficult to obtain. We also review the literature data related to Hodgkin's lymphoma-associated MAS.
Martinaud
C
C
Fédération des laboratoires, HIA Sainte-Anne, 2, boulevard Sainte-Anne, BP 20545, 83041 Toulon cedex 9, France. christophe.martinaud@inserm.fr
Cournac
J-M
JM
Pons
S
S
Gaillard
T
T
Darles
C
C
de Jaureguiberry
J-P
JP
Brisou
P
P
D000368:Aged; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D055501:Macrophage Activation Syndrome / Q000209:etiology*; D008297:Male