title: Synthesis and in vitro cytotoxicity of cis-[Pt(NH(3))(NH(2)OH)Cl(2)].
abstract: A novel mixed NH(3)/NH(2)OH platinum(II) complex cis-[Pt(NH(3))(NH(2)OH)Cl(2)] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and (1)H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.
authors.affiliation: Kunming Institute of Precious Metals, 650106, Kunming, China.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Ye
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Xi-Zhu
authors.initials: XZ
authors.lastname: Chen
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: Qiao-Wen
authors.initials: QW
authors.lastname: Chang
authors.forename: Shu-Qian
authors.initials: SQ
authors.lastname: Hou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004355:Drug Stability; D006801:Humans; D006898:Hydroxylamines / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012995:Solubility; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D006898:Hydroxylamines; D002945:Cisplatin