Maximal 'CD80-uria' with minimal change.
Differentiation between minimal-change disease and focal segmental glomerulosclerosis remains challenging, particularly at early stages in children and adults. Garin et al. identify urinary CD80 excretion levels as a potential marker to differentiate the former entity from the latter. Thus, CD80 expression on podocytes, which was initially described in mouse models of foot process effacement and human lupus nephritis, is now brought toward clinical application for use as a diagnostic biomarker.
Kistler
Andreas D
AD
Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Reiser
Jochen
J
D000328:Adult; D000818:Animals; D018122:B7-1 Antigen / Q000652:urine*; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis* / Q000378:metabolism / Q000652:urine; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism; D008181:Lupus Nephritis / Q000378:metabolism / Q000652:urine; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D016513:Mice, SCID; D009402:Nephrosis, Lipoid / Q000175:diagnosis* / Q000378:metabolism / Q000652:urine; D050199:Podocytes / Q000378:metabolism; D012372:ROC Curve
D018122:B7-1 Antigen; D015415:Biomarkers