title: [Multiple chromophobe renal cell carcinoma: a case report].
abstract: A 46-year-old woman with gross hematuria was referred to our hospital with suspicion of bilateral renal cell carcinoma. Computed tomography (CT) showed multiple renal tumors with contrast enhancement and multiple lung nodules. Based on a diagnosis of bilateral multiple renal cell carcinoma with multiple lung metastases, a combination therapy with interferon-alpha (IFN-alpha) and 5-flurouracil (5-FU) was initiated. Six months later, all the renal and pulmonary lesions remained the same, and IFN-alpha alone was continued thereafter. One tumor in the right upper pole decreased in size during the next six years, while all the other lesions remained unchanged. Then the immunotherapy was discontinued on the basis of possibility that the tumors could be benign lesions. Three years later,the right upper renal tumor disappeared on CT, but, one of the left renal tumors showed progressive disease. The patient underwent left partial nephrectomy together with resection of neighboring small tumors. All the excised tumors were diagnosed as chromophobe renal cell carcinoma on histological examination. There has been no change with the remaining tumors for 1.5 years postoperatively.
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Tsutsumi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Soda
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kamba
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kanematsu
authors.forename: Eijiro
authors.initials: E
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ito
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009392:Nephrectomy
chemical_list: D016898:Interferon-alpha