NSAID hypersensitivity (respiratory, cutaneous, and generalized anaphylactic symptoms).
Adverse reactions to drugs have been classified as predictable (related to the pharmacologic actions of the drug) and unpredictable (related to the individual's immunologic response or genetic susceptibility). The term "drug hypersensitivity" refers to the symptoms or signs initiated by an exposure to a drug at a dose normally tolerated by nonhypersensitive persons. In this article, the current knowledge on hypersensitivity reactions to nonsteroidal antiinflammatory drugs is discussed.
Sánchez-Borges
Mario
M
Department of Allergy and Clinical Immunology, Centro Médico-Docente La Trinidad, Carretera La Trinidad-El Hatillo, Estado Miranda, Venezuela. sanchezbmario@gmail.com
D000707:Anaphylaxis / Q000139:chemically induced*; D000799:Angioedema / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D012140:Respiratory Tract Diseases / Q000139:chemically induced*; D012307:Risk Factors; D012871:Skin Diseases / Q000139:chemically induced*; D014581:Urticaria / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors