title: Iron-catalyzed C-O bond activation for the synthesis of propargyl-1,2,3-triazoles and 1,1-bis-triazoles.
abstract: The FeCl(3)-catalyzed triazole propargylation was developed. This transformation was suitable for a large scope of substituted propargyl alcohols, giving the corresponding propargyl triazoles in excellent yields (up to 96%). Further derivatization produced the 1,1-bis-triazoles in excellent yields and regioselectivity, which could be applied as potential transition metal ligands or new reagents.
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Wuming
authors.initials: W
authors.lastname: Yan
authors.forename: Qiaoyi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Petersen
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D002712:Chlorides; D005290:Ferric Compounds; D020005:Propanols; D014230:Triazoles; C028255:propargyl alcohol; C024555:ferric chloride