Conduction aphasia as an initial symptom in a patient with Creutzfeldt-Jakob disease.
We report a 59-year-old woman who presented to our facility with conduction aphasia as an initial symptom which, within 3months, was followed by generalized myoclonus and global aphasia. She had difficulty repeating words during the Korean-Western Aphasia Battery test. Diffusion-weighted MRI demonstrated ribbon-like hyperintensities in the bilateral temporal, parietal and occipital cerebral cortex. An electroencephalogram showed periodic discharges over the bilateral hemispheres, while single photo emission CT revealed diminished perfusion. After a positive finding of the 14-3-3 protein in her cerebrospinal fluid, she was diagnosed as having probable sporadic Creutzfeldt-Jakob disease.
Song
Ji-Eun
JE
Department of Neurology, Chung-Ang University College of Medicine, Heukseok-dong, Dongjak-gu, Seoul 156-755, Republic of Korea.
Yang
Dong-Won
DW
Seo
Hyun-Jin
HJ
Ha
Sam-Yeol
SY
Park
Kwang-Yeol
KY
Kwon
Oh-Sang
OS
Youn
Young Chul
YC
D018886:Aphasia, Conduction / Q000209:etiology*; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods