Bioprospecting microbial natural product libraries from the marine environment for drug discovery.
Marine microorganisms are fascinating resources due to their production of novel natural products with antimicrobial activities. Increases in both the number of new chemical entities found and the substantiation of indigenous marine actinobacteria present a fundamental difficulty in the future discovery of novel antimicrobials, namely dereplication of those compounds already discovered. This review will share our experience on the taxonomic-based construction of a highly diversified and low redundant marine microbial natural product library for high-throughput antibiotic screening. We anticipate that libraries such as these can drive the drug discovery process now and in the future.
Liu
Xiangyang
X
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
Ashforth
Elizabeth
E
Ren
Biao
B
Song
Fuhang
F
Dai
Huanqin
H
Liu
Mei
M
Wang
Jian
J
Xie
Qiong
Q
Zhang
Lixin
L
D000890:Anti-Infective Agents / Q000302:isolation & purification*; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism*; D055808:Drug Discovery / Q000379:methods*; D057166:High-Throughput Screening Assays; D006801:Humans; D012623:Seawater / Q000382:microbiology*; D054852:Small Molecule Libraries
D000890:Anti-Infective Agents; D001688:Biological Products; D054852:Small Molecule Libraries