title: Utility of FDG PET/CT in guiding antifungal therapy in acute leukemia patients with chronic disseminated candidiasis.
abstract: In this study, we report the results of using fluorine deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to guide the antifungal therapy against chronic disseminated candidiasis in patients with acute leukemia. Three adult patients were enrolled in this study. All patients underwent a series of PET/CT scans during the course of antifungal therapy. Antifungal therapy was modified based on the change of the FDG activity in the known sites of the fungal infection. With the guidance of FDG PET/CT, all 3 patients achieved favorable outcomes with long-term follow-up. FDG PET/CT appeared to be a valuable modality in designing proper antifungal therapy against chronic disseminated candidiasis in patients with acute leukemia.
authors.affiliation: Department of Hematology, Nanfang Hospital, The Southern Medical University, Guangzhou, People's Republic of China. xubingzhangjian@126.com
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Shi
authors.forename: Hubing
authors.initials: H
authors.lastname: Wu
authors.forename: Xutao
authors.initials: X
authors.lastname: Guo
authors.forename: Quanshi
authors.initials: Q
authors.lastname: Wang
authors.forename: Shuyun
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D019788:Fluorodeoxyglucose F18