[Research progress of cartilage oligomeric matrix protein].
OBJECTIVE
To review the research progress of cartilage oligomeric matrix protein (COMP).


METHODS
Domestic and abroad literature about COMP was reviewed and summarized.


RESULTS
COMP was one of the osteoarthritis (OA) biomarkers of being widely studied. Most studies in recent years could draw the conclusion that COMP was associated with OA. COMP was the foremost biomarker among investigated biomarkers. It could been continuously expressed and predicted knee OA progression.


CONCLUSIONS
Precisely what role COMP plays in OA pathogenesis remains unclear, using COMP as a tool to early diagnose OA more studies would be needed.
Bai
Lunhao
L
Department of Spine and Joint, Shengjing Hospital, China Medical University, Shenyang Liaoning, 110001, P.R. China. bailh@cmu2h.com
Wang
Yu
Y
Zhang
Tianpeng
T
D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010003:Osteoarthritis / Q000175:diagnosis
D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins