Terpioside B, a difucosyl GSL from the marine sponge Terpios sp. is a potent inhibitor of NO release.
Terpioside B (2a), a unique glycolipid containing two fucose residues in the furanose form in its pentasaccharide chain, was isolated from the marine sponge Terpios sp. Its complete stereostructure was solved by interpretation of mass spectrometric and NMR data along with CD and GG-MS analyses of its degradation products. Terpioside B is a potent inhibitor against LPS-induced NO release, and is considerably more active than simpler glycosphingolipids such as terpioside A and monoglucosylceramide.
Costantino
Valeria
V
The NeaNAT group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.
Fattorusso
Ernesto
E
Mangoni
Alfonso
A
Teta
Roberta
R
Panza
Elisabetta
E
Ianaro
Angela
A
D000818:Animals; D002460:Cell Line; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000276:immunology*; D011161:Porifera / Q000737:chemistry*
D006017:Glycolipids; D008070:Lipopolysaccharides; C553482:terpioside B; D009569:Nitric Oxide