The LAT story: a tale of cooperativity, coordination, and choreography.
The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.
Balagopalan
Lakshmi
L
LCMB/CCR/NCI/NIH, Bethesda, Maryland 20892-4256, USA.
Coussens
Nathan P
NP
Sherman
Eilon
E
Samelson
Lawrence E
LE
Sommers
Connie L
CL
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D019070:Cell Lineage; D003001:Cloning, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D008967:Molecular Biology / Q000379:methods; D009154:Mutation; D010169:Palmitic Acids / Q000737:chemistry; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*; D015533:Transcriptional Activation
D048868:Adaptor Proteins, Signal Transducing; C110810:LAT protein, human; C491734:Lat protein, mouse; D008565:Membrane Proteins; D010169:Palmitic Acids; D010750:Phosphoproteins