Direct microbicidal activity of cytotoxic T-lymphocytes.
Cytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and fungi. Here, we review past and recent findings demonstrating the direct microbicidal activity of both CD4(+) and CD8(+) CTL against various microbial pathogens. Further, this review will outline what is known regarding the mechanisms of direct killing and their underlying signalling pathways.
Oykhman
Paul
P
Snyder Institute for Infection, Inflammation and Immunity, University of Calgary, Calgary, AB, Canada T2N 4N1.
Mody
Christopher H
CH
D000818:Animals; D001419:Bacteria; D015704:CD4 Antigens; D016827:CD8 Antigens; D002176:Candida albicans; D003455:Cryptococcus neoformans; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D012547:Schistosoma; D015398:Signal Transduction / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000382:microbiology; D014122:Toxoplasma
D015704:CD4 Antigens; D016827:CD8 Antigens