Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments.
BACKGROUND
Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols.


OBJECTIVE
The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies.


METHODS
Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established.


RESULTS
The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex.


CONCLUSIONS
EEG points provide a useful way to optimally identify DLPFC.
Fitzgerald
Paul B
PB
Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, Victoria, Australia. paul.fitzgerald@med.monash.edu.au
Maller
Jerome J
JJ
Hoy
Kate E
KE
Thomson
Richard
R
Daskalakis
Zafiris J
ZJ
D000328:Adult; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation / Q000379:methods*