Appropriately assessing renal function for drug dosing.
Chronic kidney disease affects millions of Americans. Many drugs are eliminated from the body by the kidneys. As renal function declines due to the disease, drugs that are normally eliminated by the kidneys can accumulate, potentially leading to toxicity. Assessing kidney function in patients is essential in determining the appropriate dose of medications to achieve the desired clinical outcome while minimizing the potential for toxicity.
Dong
Kimberly
K
School of Pharmacy, University of California San Francisco, San Francisco, CA, USA. kimberly.m.dong@gmail.com
Quan
David J
DJ
D000367:Age Factors; D001835:Body Weight; D003404:Creatinine / Q000097:blood*; D018753:Diet, Protein-Restricted / Q000379:methods; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008433:Mathematics; D008657:Metabolic Clearance Rate; D017410:Practice Guidelines as Topic; D012720:Severity of Illness Index; D012727:Sex Characteristics; D014481:United States; D014486:United States Food and Drug Administration
D003404:Creatinine