title: Does reflux have an effect on nasal mucociliary transport?
abstract: CONCLUSIONS
  Gastroesophageal and laryngopharyngeal reflux were found to have no effect on nasal mucociliary transport.
  
  
  OBJECTIVE
  Gastroesophageal and laryngopharyngeal reflux have been recognized as causative factors for chronic rhinosinusitis but no definite mechanism has been described yet. We aimed to determine whether gastroesophageal and laryngopharyngeal reflux impair nasal mucociliary transport.
  
  
  METHODS
  This was a prospective cohort study in a tertiary referral center. Fifty patients with both laryngopharyngeal and gastroesophageal reflux comprised the study group. Reflux syndrome index and reflux finding score were calculated for each patient before and after treatment. Antireflux medication was given for 12 weeks. The control group consisted of 30 healthy volunteers. Nasal mucociliary transport was assessed by means of the saccharine test. It was performed before and after the treatment. Statistical analysis was performed using the saccharine test results of the study and control groups.
  
  
  RESULTS
  No statistical difference was found between the saccharine test results of the study group and control group before treatment. The differences between the pretreatment and post-treatment reflux symptom index and reflux finding scores were statistically significant. The difference between the post-treatment saccharine test results of the patients in whom reflux scores returned to normal and those with remaining high scores was not statistically significant.
authors.affiliation: Department of Otolaryngology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ruhi
authors.initials: R
authors.lastname: Durmus
authors.forename: Baris
authors.initials: B
authors.lastname: Naiboglu
authors.forename: Arman
authors.initials: A
authors.lastname: Tek
authors.forename: Mesut
authors.initials: M
authors.lastname: Sezikli
authors.forename: Züleyha Akkan
authors.initials: ZA
authors.lastname: Cetinkaya
authors.forename: Sema Zer
authors.initials: SZ
authors.lastname: Toros
authors.forename: Talip Murat
authors.initials: TM
authors.lastname: Eriman
authors.forename: Erol
authors.initials: E
authors.lastname: Egeli
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D009297:Nasal Mucosa / Q000503:physiopathology*; D011446:Prospective Studies; D055815:Young Adult