Insulin release: shedding light on a complex matter.
SNAP25 and syntaxin-1 are core proteins of the exocytosis machinery for insulin granules. Takahashi et al. (2010) show that the distribution and kinetics of the SNAP25/syntaxin-1 complex assembly play a key role in regulating the first and second phase of insulin release.
Solimena
Michele
M
Paul Langerhans Institute Dresden, School of Medicine, Dresden, Germany. michele.solimena@tu-dresden.de
Speier
Stephan
S