Magnetic resonance elastography of uterine leiomyomas: a feasibility study.
OBJECTIVE
To determine the feasibility of performing in vivo magnetic resonance elastography (MRE) for uterine leiomyoma.


METHODS
Pilot study.


METHODS
Academic medical center.


METHODS
Six subjects planning surgical excision of uterine leiomyomas.


METHODS
MRE before planned surgery.


METHODS
Achieving an appropriate phase signal-to-noise ratio (PSNR) in the leiomyoma to allow assessment of leiomyoma elasticity in kilopascals (kPa).


RESULTS
MRE was successful in all subjects for uteri ranging from 100 to >1,000 g. Subjects had body mass indexes ranging from 23.0 to 38.0 kg/m2. Appropriate PSNRs, ranging from 5.45 to 42.28, were achieved for leiomyomas in all subjects. Mean elasticity of uterine leiomyomas ranged from 3.95 to 6.68 kPa.


CONCLUSIONS
MRE is a feasible technique for studying the in vivo mechanical properties of uterine leiomyomas and demonstrates significant heterogeneity in elasticity between lesions. Further work is necessary to optimize the technique and understand the clinical utility of this technique for women with uterine leiomyomas.
Stewart
Elizabeth A
EA
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. stewart.elizabeth@mayo.edu
Taran
F Andrei
FA
Chen
Jun
J
Gostout
Bobbie S
BS
Woodrum
David A
DA
Felmlee
Joel P
JP
Ehman
Richard L
RL
D000328:Adult; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D010865:Pilot Projects; D011300:Preoperative Care / Q000379:methods*; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000601:surgery