Intravesical oxybutynin protects the vesical wall against functional and smooth muscle changes in rabbits with detrusor overactivity.
OBJECTIVE
The aim of this study was to evaluate the protective effect of intravesical oxybutynin on the bladder wall of rabbits with detrusor overactivity and partial bladder outlet obstruction (PBOO).


METHODS
Forty-five North Folk male rabbits were randomly distributed into GI, used as control (n = 15), GII-PBOO (n = 14), and GIII-PBOO + intravesical oxybutynin (n = 15). Connective tissue and elastic fibers were quantified as volumetric density on picrosirius red and Weigert's Fuchsin-Resorcin-stained sections, respectively.


RESULTS
In T2, bladder weight was significantly higher in animals in GII and GIII. Smooth muscle bundle diameter was increased by 42% in GII compared with GI (p < 0.02).Elastic fibers were significantly higher in GII and GIII as compared with control group. Collagen concentration in GIII and GII was significantly lower than G1 (p < 0.025).


CONCLUSIONS
Intravesical oxybutynin protected against structural and functional detrusor modifications of the partially obstructed bladder.
Polido Júnior
Armando
A
Department of Urology, School of Medicine, UNESP, Botucatu, Brazil.
Costa
José Mateus
JM
Munhoz
Tânia
T
Sampaio
Francisco José
FJ
Cardoso
Luiz Eduardo Macedo
LE
Amaro
João Luiz
JL
D000818:Animals; D003094:Collagen / Q000378:metabolism; D004547:Elastic Tissue / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use*; D023421:Models, Animal; D009130:Muscle, Smooth / Q000378:metabolism / Q000503:physiopathology*; D010276:Parasympatholytics / Q000627:therapeutic use; D011817:Rabbits; D016896:Treatment Outcome; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy / Q000503:physiopathology; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000503:physiopathology*
D008333:Mandelic Acids; D010276:Parasympatholytics; D003094:Collagen; C005419:oxybutynin