title: Highly efficient asymmetric organocatalytic Friedel-Crafts alkylation of indoles with alpha,beta-unsaturated aldehydes.
abstract: The development of an improved organocatalyst, N-isopropylated bipyrrolidine 2a, for the asymmetric Friedel-Crafts alkylation of indoles with alpha,beta-unsaturated aldehydes has been presented. The new organocatalyst readily facilitates the enantioselective alkylation reaction, providing 3-alkylated indoles in good to high yields (62-89%) with high levels of enantioselectivity (80-93% ee) using only 2 mol% of catalyst loading.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
authors.forename: Shangbin
authors.initials: S
authors.lastname: Jin
authors.forename: Chenguang
authors.initials: C
authors.lastname: Li
authors.forename: Yuanhui
authors.initials: Y
authors.lastname: Ma
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Kan
authors.forename: Yong Jian
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Wanbin
authors.initials: W
authors.lastname: Zhang