A novel HLA-DRB1 allele, DRB1*08:36, identified by sequence-based typing.
A novel human leukocyte antigen (HLA)-DRB1 allele, DRB1*08:36, has been identified during routine sequence-specific oligonucleotide (SSO) typing and sequence-based typing (SBT) in a sample from a registered donor of Chinese Marrow Donor Program. The DRB1*08:36 allele differs from the closest related DRB1*08:03:02 allele by one nucleotide substitution in exon 2, at position 181 which results in an amino acid replacement at codon 32. Tyr is exchanged for His in the novel allele. These findings add a novel member to the HLA-DRB1*08 family.
Liu
J
J
Beijing Red Cross Blood Center, HLA Lab, Beijing, China. zzxhla@yahoo.com.cn
Liu
N
N
Shan
X
X
Li
W
W
Zhang
Z
Z
D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D002681:China; D004247:DNA / Q000235:genetics; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012689:Sequence Homology, Nucleic Acid
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA