title: Demographic and urodynamic factors associated with persistent OAB after anterior compartment prolapse repair.
abstract: BACKGROUND
  Overactive bladder (OAB) symptoms often accompany pelvic organ prolapse. While there seems to be a relationship between symptom resolution and anatomic repair, a subset of patients will not experience improvement in OAB symptoms. Our aim was to identify preoperative demographic and urodynamic (UD) parameters related to persistence of OAB symptoms after anterior vaginal prolapse (AVP) repair.
  
  
  METHODS
  This retrospective cohort study examined demographic and UD data from patients undergoing AVP surgery. Pre- and post-operative Urogenital Distress Inventory (UDI-6) scores for frequency, urge urinary incontinence (UUI), and difficulty voiding were analyzed, as were correlations between scores and pre-operative UD data.
  
  
  RESULTS
  From 2002 to 2008, 88 patients underwent AVP repair and were included in the final analysis. Surgery resulted in a reduction of frequency (33%), UUI (49%), and difficulty voiding (74%) at median 21 months follow-up. Change in symptom scores was unrelated to age, parity, BMI, or AVP grade, although older women reported greater improvement in difficulty emptying after repair. Improvement in difficulty emptying was related to a larger pre-operative post-void residual (PVR) (129 ml vs. 31 ml, P = 0.0008). Persistent UUI after repair was significantly related to a higher preoperative P(det)Q(max) (OR 1.056, 95% CI 1.003-1.11, P = 0.04). Other pre-operative UDS variables were not significantly related to the persistence of OAB symptoms.
  
  
  CONCLUSIONS
  AVP repair reduces lower urinary tract symptoms (LUTS); however, 67% and 51% of patients will report persistent frequency and UUI, respectively, post-operatively. In this cohort, persistent OAB symptoms were not related to age, parity, BMI, or prolapse grade, but rather to pre-operative P(det)Q(max).
authors.affiliation: Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 77030, USA. sgfletcher@tmhs.edu
authors.forename: Sophie G
authors.initials: SG
authors.lastname: Fletcher
authors.forename: Rashel M
authors.initials: RM
authors.lastname: Haverkorn
authors.forename: Jingsheng
authors.initials: J
authors.lastname: Yan
authors.forename: Joy J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Philippe E
authors.initials: PE
authors.lastname: Zimmern
authors.forename: Gary E
authors.initials: GE
authors.lastname: Lemack
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013781:Texas; D013997:Time Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000503:physiopathology*; D053201:Urinary Bladder, Overactive / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D053202:Urinary Incontinence, Urge / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D014563:Urodynamics; D014596:Uterine Prolapse / Q000150:complications / Q000503:physiopathology / Q000601:surgery*