title: Post-transcriptional controls - adding a new layer of regulation to clock gene expression.
abstract: Living organisms undergo biochemical, physiological and behavioral cycles with periods ranging from seconds to years. Cycles with intermediate periods are governed by endogenous clocks that depend on oscillating gene expression. Here we illustrate the modalities and specific functions of post-transcriptional control of gene expression (exerted on pre-mRNAs and mRNAs) in biological clocks through two examples: the circadian clock and the vertebrate somite segmentation clock, an embryonic clock with a period far below a day. We conclude that both constitutive and cyclic post-transcriptional controls underpin clock function.
authors.affiliation: Université de Rennes 1, Université Européenne de Bretagne, Institut Fédératif de Recherche 140, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Cibois
authors.forename: Carole
authors.initials: C
authors.lastname: Gautier-Courteille
authors.forename: Vincent
authors.initials: V
authors.lastname: Legagneux
authors.forename: Luc
authors.initials: L
authors.lastname: Paillard
mesh_terms: D000818:Animals; D001683:Biological Clocks; D002940:Circadian Rhythm; D047108:Embryonic Development; D005786:Gene Expression Regulation; D006801:Humans; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics; D019170:Somites / Q000378:metabolism
chemical_list: D012333:RNA, Messenger