The complete genome and genetic characteristics of SRV-4 isolated from cynomolgus monkeys (Macaca fascicularis).
At least 5 serotypes of exogenous simian retrovirus type D (SRV/D) have been found in nonhuman primates, but only SRV-1, 2 and 3 have been completely sequenced. SRV-4 was recovered once from cynomolgus macaques in California in 1984, but its genome sequences are unknown. Here we report the second identification of SRV-4 and its complete genome from infected cynomolgus macaques with Indochinese and Indonesian/Indochinese mixed ancestry. Phylogenetic analysis demonstrated that SRV-4 was distantly related to SRV-1, 2, 3, 5, 6 and 7. SRV/D-T, a new SRV/D recovered in 2005 from cynomolgus monkeys at Tsukuba Primate Center in Japan, clustered with the SRV-4 isolates from California and Texas and was shown to be another occurrence of SRV-4 infection. The repeated occurrence of SRV-4 in cynomolgus monkeys in different areas of the world and across 25years suggests that this species is the natural host of SRV-4.
Zao
Chih-Ling
CL
VRL Laboratories, San Antonio, TX 78229, USA. chih-ling.zao@vrl.net
Armstrong
Karyn
K
Tomanek
Lisa
L
Cooke
Anthony
A
Berger
Ron
R
Estep
J Scot
JS
Marx
Preston A
PA
Trask
Jessica Satkoski
JS
Smith
David G
DG
Yee
Joann L
JL
Lerche
Nicholas W
NW
D000818:Animals; D002140:California; D016679:Genome, Viral; D007564:Japan; D008252:Macaca fascicularis / Q000821:virology*; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000821:virology*; D012192:Retroviridae Infections / Q000662:veterinary* / Q000821:virology; D015301:Retroviruses, Simian / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D013781:Texas; D014412:Tumor Virus Infections / Q000662:veterinary* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins