title: [Efficacy of local heparinoids on preventing edema and ecchymosis after rhinoplasty].
abstract: OBJECTIVE
  In this study, the effect of local heparinoids on prevention of periorbital edema and ecchymosis due to rhinoplasty was investigated.
  
  
  METHODS
  Twenty patients (12 males, 8 females, mean age 23.3 years; range 19 to 34 years) who had bilateral osteotomy were randomly administered postoperative local heparinoid on one periorbital region, without performing any care in the other one. One and a half centimeter of heparinoid was applied once a day for nine days. The other periorbital region was used as control group. The heparinoid was applied additionally, 8 mg dexamethasone i.v was administered to all patients 30 minutes before the surgery and 24 hours after the surgery. Photographs of each patient which were taken on postoperative days 1, 3, 5 and 9 were evaluated as double-blind by two observers. Scoring was performed according to edema and ecchymosis scales.
  
  
  RESULTS
  There was no statistical difference with respect to edema and ecchymosis between local heparinoid treated and control eyes.
  
  
  CONCLUSIONS
  No hypersensitivity to drugs occurred in any patients. After analysing the scores, we observed that heparanoids administered locally was not effective in preventing periorbital edema and ecchymosis after rhinoplasty (p>0.05).
authors.affiliation: Inönü Universitesi Tip Fakültesi, Malatya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kelleş
authors.forename: Tamer
authors.initials: T
authors.lastname: Erdem
authors.forename: Yezdan
authors.initials: Y
authors.lastname: Fırat
authors.forename: M Tayyar
authors.initials: MT
authors.lastname: Kalcıoğlu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akarçay
authors.forename: Erol
authors.initials: E
authors.lastname: Selimoğlu
authors.forename: Saim
authors.initials: S
authors.lastname: Yoloğlu
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004438:Ecchymosis / Q000188:drug therapy / Q000517:prevention & control*; D004487:Edema / Q000517:prevention & control*; D005260:Female; D006496:Heparinoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010027:Osteotomy / Q000379:methods; D011184:Postoperative Period; D012225:Rhinoplasty / Q000009:adverse effects* / Q000379:methods; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D006496:Heparinoids; D003907:Dexamethasone