title: [Assessing lenalidomide for treating multiple myeloma, myelofibrosis and myelodysplastic syndrome].
abstract: OBJECTIVE
  Lenalidomide (LDM) is an immunomodulatory and anti-angiogenic drug which has been shown to be effective in several haematological disorders (multiple myeloma [MM], myeloid metaplasia with myelofibrosis [MF] and myelodysplastic syndrome [MDS]). The objective of this study is to evaluate the effectiveness and tolerability of LDM in our patients.
  
  
  METHODS
  Retrospective observational study which included patients at our hospital who were monitored by the haematology unit, diagnosed with MM, MF and MDS and candidates for LDM treatment. Treatment effectiveness was assessed after approximately 4 cycles of treatment.
  
  
  RESULTS
  Between February 2007 and March 2008, 16 patients were listed as candidates for receiving treatment with LDM (50% female/50% male, with a mean age of 69.6 years); of these candidates, 3 never initiated treatment. Five of the six patients with MM treated at our hospital obtained some sort of response (83.3%). Of the 4 patients with MF, 2 (66.6%) experienced some sort of response to treatment. Of the 6 patients diagnosed with MDS, treatment was initiated in 3, and it had to be suspended in 2 cases due to different reasons. Treatment only had to be suspended in two of the 13 patients who began it (15.4%) due to adverse effects (AE).
  
  
  CONCLUSIONS
  LDM is well-tolerated and produces sustained clinical benefits, especially in MM and MF. More studies are needed for in-depth examination of treatment duration, new indications and the use of treatments combined with other drugs.
authors.affiliation: Servicio de Farmacia, Hospital General de Elda, Alicante, España. hernandez_carpra@gva.es
authors.forename: C
authors.initials: C
authors.lastname: Hernández Prats
authors.forename: F
authors.initials: F
authors.lastname: Romero Iborra
authors.forename: E
authors.initials: E
authors.lastname: Arroyo Domingo
authors.forename: I
authors.initials: I
authors.lastname: Castillo Valero
authors.forename: M
authors.initials: M
authors.lastname: Real Panisello
authors.forename: M I
authors.initials: MI
authors.lastname: Sánchez Casado
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077269:Lenalidomide; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D055728:Primary Myelofibrosis / Q000188:drug therapy*; D012189:Retrospective Studies; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D013792:Thalidomide; D000077269:Lenalidomide