title: Successful treatment of vancomycin-resistant Enterococcus faecium ventriculitis with combined intravenous and intraventricular chloramphenicol in a newborn.
abstract: Vancomycin-resistant Enterococcus faecium (VRE) infection is a rare event in paediatric patients and often occurs under immunosuppression or after surgical intervention. We report what we believe to be the first paediatric case of ventriculitis due to VRE (in a 2-month-old infant) to be successfully treated with combined intravenous (i.v.) and intraventricular chloramphenicol after failure of i.v. linezolid and intraventricular gentamicin.
authors.affiliation: Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Hartmann
authors.affiliation: Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Corinna
authors.initials: C
authors.lastname: Peter
authors.affiliation: Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Elvis
authors.initials: E
authors.lastname: Hermann
authors.affiliation: Department of Pediatric Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Benno
authors.initials: B
authors.lastname: Ure
authors.affiliation: Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Ludwig
authors.initials: L
authors.lastname: Sedlacek
authors.affiliation: Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Gesine
authors.initials: G
authors.lastname: Hansen
authors.affiliation: Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Bohnhorst
mesh_terms: D000081:Acetamides / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002552:Cerebral Ventricles / Q000382:microbiology* / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000382:microbiology; D002701:Chloramphenicol / Q000008:administration & dosage*; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy; D016984:Enterococcus faecium / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007276:Injections, Intraventricular; D000069349:Linezolid; D008161:Lumbosacral Region / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D023303:Oxazolidinones / Q000008:administration & dosage; D010388:Pelvis / Q000000981:diagnostic imaging; D011859:Radiography; D016896:Treatment Outcome; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D023303:Oxazolidinones; D002701:Chloramphenicol; D000069349:Linezolid