title: Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives.
abstract: An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC(50) values.
authors.affiliation: Department of Chemistry, North Carolina State University, 2620 Yarbrough Dr., Raleigh, NC 27695-8204, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rogers
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Whitehead
authors.forename: Trey
authors.initials: T
authors.lastname: Mullikin
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010627:Phenethylamines / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology*
chemical_list: D002219:Carbamates; D010627:Phenethylamines