Alpha-glucosidase inhibitory activity of bromophenol purified from the red alga Polyopes lancifolia.
A bromophenol, bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, was purified from the red alga Polyopes lancifolia. Its IC(50) values were 0.098 and 0.120 microM against Saccharomyces cerevisiae and Bacillus stearothermophilus alpha-glucosidases, respectively, and 1.00 and 1.20 mM against rat-intestinal sucrase and maltase. This bromophenol competitively inhibited S. cerevisiae alpha-glucosidase with a K(I) value of 0.068 microM and was very stable at pH 2 for 60 min at 37 degrees C. Therefore, this P. lancifolia bromophenol may have potential as natural nutraceutical for the management of type 2 diabetes.
Kim
Keun Young
KY
Dept. of Marine Food Science and Technology, Gangneung-Wonju Natl. Univ., Gangneung 210-702, Republic of Korea.
Nguyen
The Han
TH
Kurihara
Hideyuki
H
Kim
Sang Moo
SM
D000818:Animals; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D000461:Rhodophyta / Q000737:chemistry* / Q000201:enzymology*
D002396:Catechols; D004791:Enzyme Inhibitors; D004987:Ethers; D065089:Glycoside Hydrolase Inhibitors; D010636:Phenols; C000601939:bis(2,3-dibromo-4,5-dihydroxybenzyl) ether; C013930:2,4-dibromophenol