title: Endoscopic ultrasound-guided fine needle aspiration of pancreatic masses: the utility and impact on management of patients.
abstract: OBJECTIVE
  It is controversial whether endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is beneficial in all patients with suspected pancreatic cancer. The aim of this study was to assess diagnostic yield, safety and impact of EUS-FNA on management of patients with solid pancreatic mass.
  
  
  METHODS
  Consecutive patients undergoing EUS-FNA of solid pancreatic mass were enrolled. Gold standard for final diagnosis included histology from surgical resection. In patients without surgery, clinical evaluation methods and repeated imaging studies were used for the comparison of initial cytology and final diagnosis. Patients were followed-up prospectively focusing on subsequent treatment.
  
  
  RESULTS
  Among 207 enrolled patients, final diagnosis was malignant in 163 (78.6%) and benign in 44 (21.4%). The sensitivity, specificity and accuracy of EUS-FNA in diagnosing pancreatic cancer were 92.6% (95% CI: 87.20-95.96), 88.6% (95% CI: 74.64-95.64) and 91.8% (95% CI: 87.24-94.81), respectively. No major and five (2.4%) minor complications occurred. Of 151 true-positive patients by EUS-FNA, 57 (37.7%) were surgically explored, of whom 28 (49.1%) underwent resection. Ten of 12 patients with false-negative cytology were explored based on detection of mass on EUS, of whom two had a delay due to false-negative cytology without curative treatment. From the whole study cohort, EUS-FNA had positive and negative impacts on subsequent management in 136 (65.7%) and 2 (0.9%) patients, respectively.
  
  
  CONCLUSIONS
  EUS-FNA provides accurate diagnosis in 92% and has positive therapeutic impact in two-thirds of patients with solid pancreatic mass. Despite negative cytology, surgical exploration is recommended in clinical suspicion for pancreatic cancer and solid mass on EUS.
authors.affiliation: Department of Gastroenterology, Hospital Vitkovice, Ostrava, Czech Republic. martin.kliment@nemvitkovice.cz
authors.forename: Martin
authors.initials: M
authors.lastname: Kliment
authors.forename: Ondrej
authors.initials: O
authors.lastname: Urban
authors.forename: Martin
authors.initials: M
authors.lastname: Cegan
authors.forename: Petr
authors.initials: P
authors.lastname: Fojtik
authors.forename: Premysl
authors.initials: P
authors.lastname: Falt
authors.forename: Jana
authors.initials: J
authors.lastname: Dvorackova
authors.forename: Martin
authors.initials: M
authors.lastname: Lovecek
authors.forename: Martin
authors.initials: M
authors.lastname: Straka
authors.forename: Frantisek
authors.initials: F
authors.lastname: Jaluvka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods*; D019160:Endosonography / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results