Design of optimized diffusion-controlled transdermal drug delivery systems.
BACKGROUND
We describe a systematic approach to designing multilayer transdermal patches based on therapeutically relevant specifications of the drug.


METHODS
Random search optimization techniques are used to optimize maximum drug release from the patch subject to the therapeutic specifications. Barrier layer thickness and relative concentrations of the drug in the drug-containing layers are used as key design parameters.


RESULTS
A patch made of two drug-containing layers of equal thicknesses and relative drug concentrations of 20% and 80%, and a barrier layer with thickness of 14% compared to the total thickness of drug-containing layers was found to be the most optimum design.


CONCLUSIONS
The proposed design is almost universally applicable and satisfies therapeutically relevant specifications while maximizing drug utilization.
Nauman
E Bruce
EB
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Patel
Kandarp
K
Karande
Pankaj
P
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry*; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects*; D057968:Transdermal Patch
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers