title: Transcriptomic underpinning of toxicant-mediated physiological function alterations in three terrestrial invertebrate taxa: a review.
abstract: Diverse anthropogenic activities often lead to the accumulation of inorganic and organic residues in topsoils. Biota living in close contact with contaminated soils may experience stress at different levels of biological organisation throughout the continuum from the molecular-genetic to ecological and community levels. To date, the relationship between changes at the molecular (mRNA expression) and biochemical/physiological levels evoked by exposures to chemical compounds has been partially established in a limited number of terrestrial invertebrate species. Recently, the advent of a family of transcriptomic tools (e.g. Real-time PCR, Subtractive Suppressive Hybridization, Expressed Sequence Tag sequencing, pyro-sequencing technologies, Microarray chips), together with supporting informatic and statistical procedures, have permitted the robust analyses of global gene expression changes within an ecotoxicological context. This review focuses on how transcriptomics is enlightening our understanding of the molecular-genetic responses of three contrasting terrestrial macroinvertebrate taxa (nematodes, earthworms, and springtails) to inorganics, organics, and agrochemicals.
authors.affiliation: Univ Lille Nord de France, F59000 Lille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Brulle
authors.forename: A John
authors.initials: AJ
authors.lastname: Morgan
authors.forename: Claude
authors.initials: C
authors.lastname: Cocquerelle
authors.forename: Franck
authors.initials: F
authors.lastname: Vandenbulcke
mesh_terms: D016573:Agrochemicals / Q000633:toxicity; D000818:Animals; D001181:Arthropods / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D008670:Metals / Q000633:toxicity; D009348:Nematoda / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D009835:Oligochaeta / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D012989:Soil Pollutants / Q000633:toxicity*
chemical_list: D016573:Agrochemicals; D008670:Metals; D011084:Polycyclic Aromatic Hydrocarbons; D012989:Soil Pollutants