title: Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome.
abstract: Bone marrow (BM) involvement in diffuse large B-cell lymphoma (DLBCL) can be morphologically discordant from the primary tumor. Concordant BM infiltration has been shown associated with a poorer outcome in patients treated with CHOP. In order to evaluate tumor-related factors leading to BM involvement in DLBCL, we performed an integrated analysis of i) genomic profiles obtained with a high-density genome wide SNP-based arrays ii) immunomorphological and iii) clinical data from 133 patients uniformly treated with R-CHOP. BM infiltration was found in 27 of 133 (20%) cases; and it was concordant in 18/27 (67%) cases. Concordant infiltration, but not discordant, influenced negatively OS, PFS and DFS and was associated with higher serum LDH, lower CR and higher PD rates. No association with cell of origin was found between BM+ and BM- DLBCL. As compared with BM- cases, BM+ DLBCL showed absence of 7q gain.
authors.affiliation: Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Chigrinova
authors.forename: Michael
authors.initials: M
authors.lastname: Mian
authors.forename: Marta
authors.initials: M
authors.lastname: Scandurra
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Greiner
authors.forename: Wing C
authors.initials: WC
authors.lastname: Chan
authors.forename: Julie M
authors.initials: JM
authors.lastname: Vose
authors.forename: Giorgio
authors.initials: G
authors.lastname: Inghirami
authors.forename: Annalisa
authors.initials: A
authors.lastname: Chiappella
authors.forename: Luca
authors.initials: L
authors.lastname: Baldini
authors.forename: Maurilio
authors.initials: M
authors.lastname: Ponzoni
authors.forename: Andrés J M
authors.initials: AJ
authors.lastname: Ferreri
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschetti
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tucci
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchetti
authors.forename: Thierry
authors.initials: T
authors.lastname: Lazure
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambotte
authors.forename: Santiago
authors.initials: S
authors.lastname: Montes-Moreno
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Piris
authors.forename: Josep Fr
authors.initials: JF
authors.lastname: Nomdedeu
authors.forename: Silvia
authors.initials: S
authors.lastname: Uccella
authors.forename: Paola M V
authors.initials: PM
authors.lastname: Rancoita
authors.forename: Ivo
authors.initials: I
authors.lastname: Kwee
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertoni
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations; D020869:Gene Expression Profiling; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis