title: Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments.
abstract: BACKGROUND
  Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols.
  
  
  OBJECTIVE
  The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies.
  
  
  METHODS
  Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established.
  
  
  RESULTS
  The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex.
  
  
  CONCLUSIONS
  EEG points provide a useful way to optimally identify DLPFC.
authors.affiliation: Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, Victoria, Australia. paul.fitzgerald@med.monash.edu.au
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fitzgerald
authors.forename: Jerome J
authors.initials: JJ
authors.lastname: Maller
authors.forename: Kate E
authors.initials: KE
authors.lastname: Hoy
authors.forename: Richard
authors.initials: R
authors.lastname: Thomson
authors.forename: Zafiris J
authors.initials: ZJ
authors.lastname: Daskalakis
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation / Q000379:methods*