Aortic valve bypass for aortic stenosis in a patient with paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.
Ghoreishi
Mehrdad
M
Department of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland, USA.
Baer
Maria R
MR
Bhargava
Ranjana
R
Stauffer
Craig E
CE
Griffith
Bartley P
BP
Gammie
James S
JS
D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D008297:Male