Calcium oxalate: calcium phosphate transformations.
Knowledge of the physical-chemical mechanisms responsible for the crystal growth and dissolution events involved in stone formation might enable the manipulation of thermodynamics in such a way as to increase the solubility of sparingly soluble phases (such as calcium oxalates and phosphates), thereby reducing the driving force for stone formation. This may be accomplished through modification of pH, reduction of supersaturation with respect to nucleating phases, and the presence of key inhibitors. If these modifications are made during the initial stages of crystallite nucleation, they could potentially reduce the participation of phases such as Randall's plaques in stone formation.
Nancollas
George H
GH
University at Buffalo, Amherst, NY 14260, USA. ghn@nsm.buffalo.edu
Henneman
Zachary J
ZJ
D000818:Animals; D002129:Calcium Oxalate / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D003460:Crystallization; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000737:chemistry; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D013816:Thermodynamics
D002130:Calcium Phosphates; D012996:Solutions; D002129:Calcium Oxalate