title: Neoadjuvant chemotherapy for operable breast cancer: individualizing locoregional and systemic therapy.
abstract: Neoadjuvant chemotherapy (NAC) is being used with increasing frequency in the multidisciplinary care of women with breast cancer. NAC can increase the chances for successful breast conservation and may decrease the need for axillary node dissection in selected patients. Some patients with chemoresistant tumors may benefit more from hormonal neoadjuvant therapy. The greatest potential for this approach is to predict responses of different breast cancers to therapy based on molecular profiles. This will accelerate better understanding of breast cancer biology and progress toward improved and more individualized therapy.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298-0011, USA. hdbear@vcu.edu
authors.forename: Harry D
authors.initials: HD
authors.lastname: Bear
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D057285:Precision Medicine