Structure determination of selaginellins G and H from Selaginella pulvinata by NMR spectroscopy.
Selaginellins G (1) and H (2), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata. Their structures were elucidated, and complete assignments of the (1)H and (13)C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC(50) value of 5.3 microg/ml.
Cao
Yuan
Y
Chen
Ji-Jun
JJ
Tan
Ning-Hua
NH
Wu
Yong-Ping
YP
Yang
Jie
J
Wang
Qiang
Q
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012015:Reference Standards; D032503:Selaginellaceae / Q000737:chemistry*; D014320:Triphenylmethyl Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D014320:Triphenylmethyl Compounds; C555110:selaginellin G