title: Preclinical effectiveness of a novel pulp capping material.
abstract: BACKGROUND
  The purpose of this study was to evaluate the direct pulp capping response to a novel resin-based calcium phosphate cement (RCPC).
  
  
  METHODS
  The RCPC was placed in contact with the exposed healthy pulps of dog teeth and in a follow-up study on the healthy or inflamed pulps of ferret teeth. The inflamed ferret teeth had reversible pulpitis induced with Salmonella typhimurium lipopolysaccharides. After direct pulp capping with RCPC or visible light-curing resin-modified calcium hydroxide material (VLCCH) as a control, the restorations were bonded using a composite resin. The pulp responses and dentin repair were evaluated histologically in dog teeth after 7, 28, or 90 days and in ferret teeth after 45 days.
  
  
  RESULTS
  Most of the RCPC-treated healthy pulps and 75% of the RCPC-treated inflamed ferret teeth had dentin healing and repair, whereas those teeth treated with VLCCH had minimal healing and dentin repair.
  
  
  CONCLUSIONS
  The direct pulp capping of ferret and dog teeth with RCPC was associated with superior healing in comparison to VLCCH.
authors.affiliation: American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, MD 20899-8546, USA. sabine.dickens@nist.gov
authors.forename: Sabine H
authors.initials: SH
authors.lastname: Dickens
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Flaim
authors.forename: Gary E
authors.initials: GE
authors.lastname: Schumacher
authors.forename: Frederick C
authors.initials: FC
authors.lastname: Eichmiller
authors.forename: Duane R
authors.initials: DR
authors.lastname: Schafer
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Rutherford
mesh_terms: D000818:Animals; D001565:Benzoates / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003188:Composite Resins / Q000737:chemistry; D003764:Dental Materials / Q000737:chemistry; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping; D003789:Dental Pulp Exposure / Q000628:therapy; D003793:Dental Restoration, Permanent / Q000379:methods; D003809:Dentin, Secondary / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005289:Ferrets; D005459:Fluorides / Q000627:therapeutic use; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D008689:Methacrylates / Q000737:chemistry / Q000627:therapeutic use; D011671:Pulpitis / Q000188:drug therapy; D011897:Random Allocation; D019279:Resin Cements / Q000627:therapeutic use*; D012486:Salmonella typhimurium; D012824:Silicic Acid / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D001565:Benzoates; D002130:Calcium Phosphates; D003188:Composite Resins; D003764:Dental Materials; C420130:Excite cement; D008070:Lipopolysaccharides; D008689:Methacrylates; D019279:Resin Cements; C121818:Tetric ceram; D012824:Silicic Acid; C080129:pyromellitic dianhydride glycerol dimethacrylate adduct; C004832:hexafluorosilicate; C074277:ethoxylated bis-phenol A dimethacrylate; C005044:hydroxyethyl methacrylate; C020243:calcium phosphate; D002126:Calcium Hydroxide; D005459:Fluorides