title: Breast cancer following radiotherapy for a hemangioma during childhood.
abstract: OBJECTIVE
  A cohort study was performed to investigate the carcinogenic effect of treatment of skin hemangioma with ionizing radiation in early childhood. This paper presents the incidence of breast cancer (BC) in this cohort and its association with radiotherapy.
  
  
  METHODS
  In an incidence study, 3,316 women treated for a skin hemangioma between 1941 and 1977 at the Institut Gustave-Roussy were included, among whom 2,697 had received radiotherapy. The mean age at first exposure was 0.7 years, and the mean absorbed dose to the breast was 70 mGy. Treatment reconstruction and the estimation of radiation doses delivered to the breast were obtained for 92% of the women who had received radiotherapy. External and internal analyses were performed.
  
  
  RESULTS
  During an average follow-up of 35 years, a total of 17 women developed an invasive BC, compared to 7.5 expected in the French general population (SIR = 2.3, 95% CI, 1.4-3.5), and the absolute excess risk strongly increased with attained age. Compared to individuals with no radiotherapy, the risk of BC increased with increasing radiation dose with RRs of 3.2, 6.3, and 8.0 for dose categories of >0-10, 10-100, and >100 mGy, respectively; however, dose-response relationship was not significant.
  
  
  CONCLUSIONS
  This study confirms that radiation treatment performed in the past for hemangioma during childhood increases the risk of BC.
authors.affiliation: Radiation Epidemiology Group, CESP Centre for research in Epidemiology and Population Health, INSERM U 1018, 94807 Villejuif, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Haddy
authors.forename: Marie-Gabrielle
authors.initials: MG
authors.lastname: Dondon
authors.forename: Catherine
authors.initials: C
authors.lastname: Paoletti
authors.forename: Carole
authors.initials: C
authors.lastname: Rubino
authors.forename: Abdeddahir
authors.initials: A
authors.lastname: Mousannif
authors.forename: Akhtar
authors.initials: A
authors.lastname: Shamsaldin
authors.forename: Françoise
authors.initials: F
authors.lastname: Doyon
authors.forename: Martine
authors.initials: M
authors.lastname: Labbé
authors.forename: Caroline
authors.initials: C
authors.lastname: Robert
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Avril
authors.forename: Rogers
authors.initials: R
authors.lastname: Demars
authors.forename: Florence
authors.initials: F
authors.lastname: Molinie
authors.forename: Dimitri
authors.initials: D
authors.lastname: Lefkopoulos
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Diallo
authors.forename: Florent
authors.initials: F
authors.lastname: de Vathaire
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006391:Hemangioma / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D007223:Infant; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011829:Radiation Dosage; D011878:Radiotherapy / Q000009:adverse effects; D012306:Risk; D012878:Skin Neoplasms / Q000150:complications / Q000532:radiotherapy*; D013997:Time Factors; D016896:Treatment Outcome