title: Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols.
abstract: Sodium laureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics. Sodium and ammonium laureth sulfate have not evoked adverse responses in any toxicological testing. Sodium laureth sulfate was demonstrated to be a dermal and ocular irritant but not a sensitizer. The Expert Panel recognized that there are data gaps regarding use and concentration of these ingredients. However, the overall information available on the types of products in which these ingredients are used and at what concentrations indicates a pattern of use. The potential to produce irritation exists with these salts of sulfated ethoxylated alcohols, but in practice they are not regularly seen to be irritating because of the formulations in which they are used. These ingredients should be used only when they can be formulated to be nonirritating.
authors.affiliation: Cosmetic Ingredient Review, Washington, DC 20036, USA. cirinfo@cir-safety.org.
authors.forename: Valerie C
authors.initials: VC
authors.lastname: Robinson
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F
authors.initials: F
authors.lastname: Alan Andersen
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D003358:Cosmetics; D006801:Humans; D012967:Sodium Dodecyl Sulfate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D013431:Sulfates / Q000737:chemistry*
chemical_list: D000438:Alcohols; D003358:Cosmetics; D013431:Sulfates; D012967:Sodium Dodecyl Sulfate; C408148:sodium laureth sulfate