Synthesis of highly substituted isoquinolone derivatives by nickel-catalyzed annulation of 2-halobenzamides with alkynes.
An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamides with alkynes is described. This protocol is successfully applied to the total synthesis of oxyavicine with excellent yield.
Liu
Chuan-Che
CC
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
Parthasarathy
Kanniyappan
K
Cheng
Chien-Hong
CH
D000480:Alkynes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010617:Phenanthridines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000480:Alkynes; D001549:Benzamides; D006846:Hydrocarbons, Halogenated; D007546:Isoquinolines; D010617:Phenanthridines; C511013:oxyavicine; D009532:Nickel