title: Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI.
abstract: Based on a commercially available hyperbranched aliphatic polyester, novel multifunctional gadolinium complexes were prepared bearing protective PEG chains, a folate targeting ligand and EDTA or DTPA chelate moieties. Their relatively high water relaxivity values coupled with biodegradability of the hyperbranched scaffold, folate receptor specificity render these non-toxic dendritic polymers promising candidates for MRI applications.
authors.affiliation: Institute of Physical Chemistry, NCSR Demokritos, 15310 Aghia Paraskevi, Attiki, Greece. zili@chem.demokritos.gr
authors.forename: Zili
authors.initials: Z
authors.lastname: Sideratou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tsiourvas
authors.forename: Theodossis
authors.initials: T
authors.lastname: Theodossiou
authors.forename: Michael
authors.initials: M
authors.lastname: Fardis
authors.forename: Constantinos M
authors.initials: CM
authors.lastname: Paleos
mesh_terms: D001672:Biocompatible Materials; D045744:Cell Line, Tumor; D003287:Contrast Media; D004492:Edetic Acid / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D004369:Pentetic Acid / Q000737:chemistry; D011091:Polyesters / Q000138:chemical synthesis*
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D011091:Polyesters; D004369:Pentetic Acid; D004492:Edetic Acid