title: Mechanical circulatory support in patients with heart failure secondary to transposition of the great arteries.
abstract: Advances in palliation of congenital heart disease have resulted in improved survival to adulthood. Many of these patients ultimately develop end-stage heart failure requiring left ventricular assist device implantation (LVAD). However, morphologic differences in the systemic ventricle of these patients require careful attention to cannula placement. We report on the evolution of our surgical technique for implanting LVADs in 3 patients with transposition of the great arteries and congenitally corrected transposition of the great arteries. Applying standard LV cannulation techniques to the systemic ventricle led us too anteriorly in our first patient, creating obstruction by the moderator band. Subsequent use of epicardial and transesophageal echocardiography allowed for intraoperative localization of the intracardiac muscular structures to identify the optimal cannulation site. The acute angle of the inflow cannula on the DeBakey LVAD (MicroMed Technology, Houston, TX) required flipping the device 180°. The HeartMate II device (Thoratec, Pleasanton, CA) could be shifted towards the midline. One patient underwent successful transplant and 2 are home waiting for a donor organ. We conclude from our experience that LVAD surgery can be safely performed in patients with congenital heart disease when implanted under echocardiographic guidance.
authors.affiliation: Department of Cardiothoracic Surgery, Stanford University Medical Center, 162 Charles Marx Way, Palo Alto, CA 94304, USA. djoyce4@gmail.com
authors.forename: David L
authors.initials: DL
authors.lastname: Joyce
authors.forename: Sheri S
authors.initials: SS
authors.lastname: Crow
authors.forename: Ranjit
authors.initials: R
authors.lastname: John
authors.forename: James D
authors.initials: JD
authors.lastname: St Louis
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Braunlin
authors.forename: Lee A
authors.initials: LA
authors.lastname: Pyles
authors.forename: Paula
authors.initials: P
authors.lastname: Kofflin
authors.forename: Lyle D
authors.initials: LD
authors.lastname: Joyce
mesh_terms: D000328:Adult; D013504:Cardiovascular Surgical Procedures / Q000379:methods*; D017548:Echocardiography, Transesophageal; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D013902:Radiography, Thoracic; D014188:Transposition of Great Vessels / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D016896:Treatment Outcome