title: Magnesium(II)-binaphtholate as a practical chiral catalyst for the enantioselective direct Mannich-type reaction with malonates.
abstract: A highly enantioselective direct Mannich-type reaction of aldimines with dialkyl malonates was developed with the use of a Mg(II)-BINOLate salt, which was designed as a cooperative acid-base catalyst that can activate both aldimines and malonates. Optically active beta-aminoesters and alpha-halo-beta-aminoesters could be synthesized in high yields and with high enantioselectivities. This inexpensive and practical Mg(II)-BINOLate salt could be used in gram-scale catalysis.
authors.affiliation: Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hatano
authors.forename: Takahiro
authors.initials: T
authors.lastname: Horibe
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara