title: [Relationship between nasal inverted papilloma and human papillomavirus subtypes].
abstract: OBJECTIVE
  To study the distribution of human papillomavirus (HPV) subtypes in nasal inverted papilloma (NIP), and to evaluate the relationship between HPV and NIP.
  
  
  METHODS
  Twenty-one HPV subtypes were detected in paraffin-embedded tissues of 101 cases of NIP by flow through hybridization and gene chip (HybriMax), 24 cases of normal nasal mucosa were used as controls.
  
  
  RESULTS
  HPV positive rates of NIP were 64.36% (65/101). Benign NIP group, NIP with atypical hyperplasia group, NIP with cancerous group of HPV positive rates were 59.7% (46/77), 81.8% (18/22) and 50% (1/2) respectively. The control group was negative (0/24). The comparison between NIP group and control group was statistically significant (chi(2) = 32.178, P < 0.05). Benign NIP group and NIP with atypical hyperplasia group were compared, but no statistically significance (chi(2) = 3.649, P = 0.056) was found. The constituent ratio of benign NIP group and NIP with atypical hyperplasia group in high, low-risk HPV subtypes infections was compared, a statistically significance (chi(2) = 10.412, P < 0.05) was found.
  
  
  CONCLUSIONS
  The occurrence of NIP was related with HPV infection. High-risk HPV subtype infections or multiple infections will prompt benign NIP to NIP with atypical hyperplasia. Understanding the distribution of HPV subtypes in the NIP is helpful to predict the clinical behavior.
authors.affiliation: Discipline of Otorhinolaryngology Head and Neck Surgery, Clinical Medicine School of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Sun
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Pei
authors.forename: Rui-xia
authors.initials: RX
authors.lastname: Ma
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.forename: Wei-gang
authors.initials: WG
authors.lastname: Dong
authors.forename: Wei-xiang
authors.initials: WX
authors.lastname: Chen
authors.forename: Hui-li
authors.initials: HL
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology / Q000821:virology*; D018308:Papilloma, Inverted / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000473:pathology*