Structure-activity relationship in binding ligands to library of artificial receptors: the search for biocompatible sensor.
Structure-activity relationship (SAR) analysis was applied for studies of docking of colored ligands to library of artificial receptors formed by self-assembly of N-lipidated amino acids immobilised on the cellulose support. The studies show that the binding depends mainly on the structure of amino acid fragment but influence of N-lipidic fragment is less important.
Frączyk
Justyna
J
Institute of Organic Chemistry, Technical University of Łódź, 90-924 Łódź, Poland.
Mrozek
Agnieszka
A
Kamiński
Zbigniew J
ZJ
D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D002482:Cellulose / Q000737:chemistry; D004396:Coloring Agents / Q000737:chemistry / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D018000:Receptors, Peptide / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry / Q000378:metabolism
D000596:Amino Acids; D001672:Biocompatible Materials; D004396:Coloring Agents; D004800:Enzymes, Immobilized; D008024:Ligands; D008055:Lipids; D011506:Proteins; D018000:Receptors, Peptide; D014227:Triazines; D002482:Cellulose; D009584:Nitrogen