title: PIVKA-II is a candidate marker for monitoring the effects of the oral anticoagulant warfarin.
abstract: OBJECTIVE
  To determine whether PIVKA-II can serve as a monitoring marker of warfarin treatment.
  
  
  METHODS
  The correlation between PIVKA-II concentration and INR was analyzed among outpatients on warfarin therapy and PIVKA-II concentration after commencement of warfarin administration was monitored for six patients.
  
  
  RESULTS
  PIVKA-II concentration and INR were significantly correlated in the patients on regular warfarin therapy. PIVKA-II level increased abruptly after start of warfarin administration.
  
  
  CONCLUSIONS
  PIVKA-II assay can be useful to monitor the efficacy of warfarin therapy.
authors.affiliation: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, Korea.
authors.forename: Woochang
authors.initials: W
authors.lastname: Lee
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Chung
authors.forename: Sollip
authors.initials: S
authors.lastname: Kim
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Jang
authors.forename: Chan-Jeoung
authors.initials: CJ
authors.lastname: Park
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Sail
authors.initials: S
authors.lastname: Chun
authors.forename: Won-Ki
authors.initials: WK
authors.lastname: Min
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000493:pharmacokinetics / Q000494:pharmacology; D015415:Biomarkers / Q000032:analysis*; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D019934:International Normalized Ratio; D008875:Middle Aged; D011498:Protein Precursors / Q000032:analysis*; D011516:Prothrombin / Q000032:analysis*; D014859:Warfarin / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D014859:Warfarin; D011516:Prothrombin