Patch testing in atopic dermatitis patients.
The exposure of atopic dermatitis (AD) patients to aeroallergens or food allergens can exacerbate or maintain the disease. Atopy patch tests (APTs) are able to identify these triggering factors and consist of the epicutaneous application of allergens for 48 hours, with an evaluation of the eczematous lesions induced after 48 and 72 hours, according to the reading criteria of the European Task Force on Atopic Dermatitis (ETFAD). APTs show a higher specificity than skin prick and specific IgE tests, since the pathophysiological mechanism of the reaction induced is very similar to that which occurs in AD lesions. The standardization of APTs to aeroallergens has brought a certain reliability to this method, which is not the case for food APTs, in which the positive predictive value must be improved to avoid any unnecessary dietary restrictions. Thus, optimization of APTs and progress in the knowledge of the pathophysiology of eczemas could help to develop new immunobiological diagnostic methods and specific immunotherapy for AD.
Nosbaum
Audrey
A
Department of Allergology and Clinical Immunology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
Hennino
Anca
A
Berard
Frédéric
F
Nicolas
Jean-François
JF
D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D010328:Patch Tests / Q000379:methods / Q000592:standards; D012680:Sensitivity and Specificity