Ubiquitous presence of gluconeogenic regulatory enzyme, fructose-1,6-bisphosphatase, within layers of rat retina.
To shed some light on gluconeogenesis in mammalian retina, we have focused on fructose-1,6-bisphosphatase (FBPase), a regulatory enzyme of the process. The abundance of the enzyme within the layers of the rat retina suggests that, in mammals in contrast to amphibia, gluconeogenesis is not restricted to one specific cell of the retina. We propose that FBPase, in addition to its gluconeogenic role, participates in the protection of the retina against reactive oxygen species. Additionally, the nuclear localization of FBPase and of its binding partner, aldolase, in the retinal cells expressing the proliferation marker Ki-67 indicates that these two gluconeogenic enzymes are involved in non-enzymatic nuclear processes.
Mamczur
Piotr
P
Department of Animal Molecular Physiology, Institute of Zoology, Wroclaw University, Cybulskiego 30, 50-205, Wroclaw, Poland.
Mazurek
Jakub
J
Rakus
Darek
D
D000818:Animals; D001253:Astrocytes / Q000201:enzymology / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology* / Q000378:metabolism; D005632:Fructose / Q000378:metabolism; D006597:Fructose-Bisphosphatase / Q000737:chemistry / Q000378:metabolism*; D005634:Fructose-Bisphosphate Aldolase / Q000737:chemistry / Q000378:metabolism; D005943:Gluconeogenesis / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D019394:Ki-67 Antigen / Q000235:genetics / Q000502:physiology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012160:Retina / Q000201:enzymology* / Q000378:metabolism
D007527:Isoenzymes; D019394:Ki-67 Antigen; D017382:Reactive Oxygen Species; D005632:Fructose; D006003:Glycogen; D006597:Fructose-Bisphosphatase; D005634:Fructose-Bisphosphate Aldolase; D005947:Glucose