title: Development of smart delivery system for ascorbic acid using pH-responsive P(MAA-co-EGMA) hydrogel microparticles.
abstract: pH-Responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. P(MAA-co-EGMA) hydrogel microparticles were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of ~ 5 and, as the amount of MAA in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the ascorbic acid into the hydrogel was affected more by the degree of swelling of the hydrogel than the electrostatic interaction between the hydrogel and the loaded ascorbic acid. The P(MAA-co-EGMA) hydrogel microparticles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the ascorbic acid permeated through the skin while at pH 6 relatively high skin permeability was obtained. The ascorbic acid loaded in the hydrogel particles was hardly degraded and its stability was maintained at high temperature.
authors.affiliation: Department of Chemical Engineering, Hongik University, 72-1 Sangsu-dong, Mapo-gu, Seoul 121-791, Korea.
authors.forename: Eunmi
authors.initials: E
authors.lastname: Lee
authors.forename: Kyusik
authors.initials: K
authors.lastname: Kim
authors.forename: Moonjae
authors.initials: M
authors.lastname: Choi
authors.forename: Youngmoo
authors.initials: Y
authors.lastname: Lee
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Park
authors.forename: Bumsang
authors.initials: B
authors.lastname: Kim
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004355:Drug Stability; D004817:Epidermis / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008689:Methacrylates / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D004337:Drug Carriers; D008689:Methacrylates; D011109:Polymethacrylic Acids; C421283:poly(ethylene glycol)-dimethacrylate; C524499:polyethylene glycol methacrylate; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D001205:Ascorbic Acid