title: Chemokines and chemokine receptors: new actors in neuroendocrine regulations.
abstract: Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells. Their role in the immune system is well-known, and it has recently been suggested that they may also play a role in the central nervous system (CNS). Indeed, they do not only act as immunoinflammatory mediators in the brain but they also act as potential modulators in neurotransmission. Although we are only beginning to be aware of the implication of chemokines in neuroendocrine functions, this review aims at summarizing what is known in that booming field of research. First we describe the expression of chemokines and their receptors in the CNS with a focus on the hypothalamo-pituitary system. Secondly, we present what is known on some chemokines in the regulation of neuroendocrine functions such as cell migration, stress, thermoregulation, drinking and feeding as well as anterior pituitary functions. We suggest that chemokines provide a fine modulatory tuning system of neuroendocrine regulations.
authors.affiliation: INSERM-UPMC, UMRS 732, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 17 rue Moreau, Paris Cedex 12, France. William.rostene@inserm.fr
authors.forename: William
authors.initials: W
authors.lastname: Rostène
authors.forename: Alice
authors.initials: A
authors.lastname: Guyon
authors.forename: Lara
authors.initials: L
authors.lastname: Kular
authors.forename: David
authors.initials: D
authors.lastname: Godefroy
authors.forename: Federica
authors.initials: F
authors.lastname: Barbieri
authors.forename: Adriana
authors.initials: A
authors.lastname: Bajetto
authors.forename: Ghazal
authors.initials: G
authors.lastname: Banisadr
authors.forename: Céline
authors.initials: C
authors.lastname: Callewaere
authors.forename: Gregory
authors.initials: G
authors.lastname: Conductier
authors.forename: Carole
authors.initials: C
authors.lastname: Rovère
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mélik-Parsadaniantz
authors.forename: Tullio
authors.initials: T
authors.lastname: Florio
mesh_terms: D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009490:Neurosecretory Systems / Q000378:metabolism / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000502:physiology; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine