title: Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial.
abstract: BACKGROUND
  Hypertrophic scar formation is a process in which prolonged angiogenesis sustained by vascular endothelial growth factor cutaneous expression plays an important role.
  
  
  OBJECTIVE
  This in vivo study was conducted to evaluate the clinical effect of a topical gel containing onion extract, allantoin, and pentaglycan on hypertrophic scars and keloids.
  
  
  METHODS
  Thirty people with hypertrophic scars or keloids were examined. Fifteen patients received a topical application of a gel containing allium cepa, allantoin, and pentaglycan twice a day for 24 weeks, the remaining 15 patients received no topical treatments. A clinical evaluation and an intravital videocapillaroscopy were performed on every patient at baseline (T0) and 24 weeks (T24) after the treatment.
  
  
  RESULTS
  Only the patients who received the topical treatment showed a significant reduction in neoangiogenetic features, demonstrated through an improvement of erythema and all videocapillaroscopic markers of neoangiogenesis. These changes induced by therapy led to a general improvement of the lesions.
  
  
  CONCLUSIONS
  Topical applications of a gel containing allium cepa, pentaglycan, and allantoin twice a day for 24 weeks seems to be useful in reducing neoangiogenesis in hypertrophic scars and keloids, resulting in clinical improvement of skin lesions. The authors have indicated no significant interest with commercial supporters.
authors.affiliation: Dermatology Clinic, Department of Clinical Medicine and Biotechnology, Universitá Politecnica delle Marche, Ancona, Italy. nati@univpm.it
authors.forename: Anna
authors.initials: A
authors.lastname: Campanati
authors.forename: Andrea
authors.initials: A
authors.lastname: Savelli
authors.forename: Lucia
authors.initials: L
authors.lastname: Sandroni
authors.forename: Barbara
authors.initials: B
authors.lastname: Marconi
authors.forename: Angela
authors.initials: A
authors.lastname: Giuliano
authors.forename: Katia
authors.initials: K
authors.lastname: Giuliodori
authors.forename: Giulia
authors.initials: G
authors.lastname: Ganzetti
authors.forename: Annamaria
authors.initials: A
authors.lastname: Offidani
mesh_terms: D000328:Adult; D000481:Allantoin / Q000627:therapeutic use*; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D006801:Humans; D007627:Keloid / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D020678:Microscopic Angioscopy; D019697:Onions; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D014741:Video Recording
chemical_list: D005782:Gels; D010936:Plant Extracts; D011134:Polysaccharides; D000481:Allantoin