Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis.
Aminoglycoside antibiotics are a central component of the treatment of pulmonary exacerbations of cystic fibrosis (CF) and slow the decline in lung function which ultimately causes the death of most patients. The prognosis of CF has improved, and thus side effects of treatments have become increasingly important. Observational studies suggest that the morbidity from side effects of aminoglycosides is disturbingly common, and that aggressive treatment may lead to more side effects. This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies. Treatments which have shown early promise are identified and areas of future research are discussed.
Prayle
Andrew
A
Child Health and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, E Floor East Block, Queen's Medical Centre, Nottingham NG7 2UH, UK.
Watson
Alan
A
Fortnum
Heather
H
Smyth
Alan
A
D000617:Aminoglycosides / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications*; D006311:Hearing Disorders / Q000139:chemically induced*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008171:Lung Diseases / Q000150:complications / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy; D015837:Vestibular Diseases / Q000139:chemically induced*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents