Aeruginazole A, a novel thiazole-containing cyclopeptide from the cyanobacterium Microcystis sp.
A novel thiazole-containing cyclic peptide, aeruginazole A (1), was isolated from the cyanobacterium Microcystis sp. strain (IL-323), which was collected from a water reservoir near Kfar-Yehoshua, Valley of Armageddon, Israel. The planar structure of aeruginazole A was established using homonuclear and inverse-heteronuclear 2D NMR techniques, as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was determined using Marfey's method. Aeruginazole A potently inhibited Bacillus subtilis.
Raveh
Avi
A
Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978, Israel.
Carmeli
Shmuel
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D007557:Israel; D046931:Microcystis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D013844:Thiazoles; C553120:aeruginazole A