title: Can chronic gastritis cause an increase in fecal calprotectin concentrations?
abstract: OBJECTIVE
  To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.
  
  
  METHODS
  FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score (mild, moderate, marked). FFCs in relation to Helicobacter pylori (H. pylori) infection and proton pump inhibitor (PPI) use were also evaluated.
  
  
  RESULTS
  FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls. Among patients with chronic active gastritis (even marked), FCCs did not significantly differ according to activity score. No significant differences in FCCs were found when considering H. pylori, as well as when considering PPI chronic use.
  
  
  CONCLUSIONS
  FCCs were not significantly increased in subjects with chronic gastritis, even in those patients with a marked neutrophil infiltration.
authors.affiliation: Institute of Internal Medicine, Catholic University, Largo Gemelli 8, 00168 Roma, Italy. mmontalto@rm.unicatt.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Montalto
authors.forename: Antonella
authors.initials: A
authors.lastname: Gallo
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ianiro
authors.forename: Luca
authors.initials: L
authors.lastname: Santoro
authors.forename: Ferruccio
authors.initials: F
authors.lastname: D'Onofrio
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ricci
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cammarota
authors.forename: Marcello
authors.initials: M
authors.lastname: Covino
authors.forename: Monica
authors.initials: M
authors.lastname: Vastola
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gasbarrini
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D002908:Chronic Disease; D005243:Feces / Q000737:chemistry*; D005260:Female; D005756:Gastritis / Q000503:physiopathology*; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex