Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice.
OBJECTIVE
To determine the effect of myocardial infarction (MI) on progression of atherosclerosis in apolipoprotein E deficient (ApoE-/-) mice.


RESULTS
MI was induced following left anterior descending coronary artery (LAD) ligation in wild-type (WT) (n=9) and ApoE-/- (n=25) mice. Compared to sham-operated animals, MI mice demonstrated increased intravascular leukocyte rolling and firm adhesion by intravital microscopy, reflecting enhanced systemic leukocyte-endothelial interactions. To determine if MI was associated with accelerated atherogenesis, LAD ligation was performed in ApoE-/- mice. Six weeks following surgery, atherosclerosis was quantitated throughout the arterial tree by microdissection and Oil-Red-O staining. There was 1.6-fold greater atherosclerotic burden present in ApoE-/- MI mice compared to sham-operated mice.


CONCLUSIONS
Acute MI accelerates atherogenesis in mice. These results may be related to the increased risk of recurrent ischemic coronary events following MI in humans.
Wright
Andrew P
AP
University of Michigan, Department of Internal Medicine, Cardiovascular Research Center, Ann Arbor, MI 48109-0644, USA.
Öhman
Miina K
MK
Hayasaki
Takanori
T
Luo
Wei
W
Russo
Hana M
HM
Guo
Chiao
C
Eitzman
Daniel T
DT
D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D050197:Atherosclerosis / Q000378:metabolism*; D001835:Body Weight; D002448:Cell Adhesion; D002784:Cholesterol / Q000378:metabolism; D004452:Echocardiography / Q000379:methods; D042783:Endothelial Cells / Q000166:cytology*; D007962:Leukocytes / Q000166:cytology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001057:Apolipoproteins E; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol