Anti-allergic drugs and the Annexin-A1 system.
This paper, which was presented at the 17th JMRC 'John Robert Vane Memorial' Symposium, describes some recent work from the authors' laboratory that provides a tentative explanation for the anti-inflammatory effects produced by the cromoglycate-like anti-allergic drugs. Some of the implications of this finding are discussed.
Yazid
Samia
S
Biochemical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Ayoub
Samir S
SS
Solito
Egle
E
McArthur
Simon
S
Vo
Phuong
P
Dufton
Neil
N
Flower
Roderick J
RJ
D017305:Annexin A1 / Q000378:metabolism*; D018926:Anti-Allergic Agents / Q000378:metabolism / Q000494:pharmacology*; D004205:Cromolyn Sodium / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism; D020298:U937 Cells
D017305:Annexin A1; D018926:Anti-Allergic Agents; D004205:Cromolyn Sodium