The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy.
There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.
Hoogduijn
Martin J
MJ
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. m.hoogduijn@erasmusmc.nl
Popp
Felix
F
Verbeek
Richard
R
Masoodi
Mojgan
M
Nicolaou
Anna
A
Baan
Carla
C
Dahlke
Marc-H
MH
D000818:Animals; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006086:Graft vs Host Disease / Q000628:therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D011453:Prostaglandins / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D011453:Prostaglandins