Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm.
We demonstrate a method to estimate the concentrations of water and lipid in scattering media such as biological tissues with diffuse optical spectra acquired over the range of 900 to 1600 nm. Estimations were performed by fitting the spectra to a model of light propagation in scattering media derived from diffusion theory. To validate the method, spectra were acquired from tissue phantoms consisting of lipid and water emulsions and swine tissues ex vivo with a two-fiber probe.
Nachabé
Rami
R
Philips Research, Minimally Invasive Healthcare Department, 5656 AE Eindhoven, The Netherlands. rami.nachabe@philips.com
Hendriks
Benno H W
BH
Desjardins
Adrien E
AE
van der Voort
Marjolein
M
van der Mark
Martin B
MB
Sterenborg
Henricus J C M
HJ
D000465:Algorithms; D000818:Animals; D001466:Barium Sulfate / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry; D050152:Intra-Abdominal Fat / Q000737:chemistry; D008055:Lipids / Q000032:analysis* / Q000737:chemistry; D008956:Models, Chemical; D009132:Muscles / Q000737:chemistry; D055095:Optics and Photonics / Q000379:methods; D010316:Particle Size; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000379:methods*; D050151:Subcutaneous Fat / Q000737:chemistry; D013552:Swine; D014465:Ultrasonics; D014867:Water / Q000032:analysis* / Q000737:chemistry
D004655:Emulsions; D008055:Lipids; D014867:Water; D001466:Barium Sulfate