The role of folic acid in prevention and treatment of depression: an overview of existing evidence and implications for practice.
OBJECTIVE
Folic acid is a promising nutrient in relation to augmentation of depression treatment efficiency. Our aim is to present an overview of the potential ways in which folic acid may be associated with depression.


METHODS
Search in the databases of PubMed, ProQuest, HEAL- LINK, and HighWire, as well as the Search Engine Google.


RESULTS
Data on the correlation of folic acid deficiency and depression is presented along with plausible mechanisms that may account for this association. Secondly, the role of folic acid in the treatment of depression is depicted giving emphasis to the potential of folic acid to enhance patients' responsivess to medication and the therapeutic outcome.


CONCLUSIONS
There is not enough data to justify prescription of folic acid as an aid in patients with severe or chronic depression or mood disorders. However, folic acid levels should be examined in individuals at increased risk for folic acid deficiency or in patients who do not respond to pharmaceutical treatment.
Lazarou
Chrystalleni
C
Harokopio University, Department of Nutrition and Dietetics, Athens, Greece. Electronic address: stalolaz@logosnet.cy.net.
Kapsou
Margarita
M
University of Cyprus, Department of Psychology, Nicosia, Cyprus.
D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D019587:Dietary Supplements; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005492:Folic Acid / Q000627:therapeutic use*; D005494:Folic Acid Deficiency / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans
D005492:Folic Acid