Predictors of mortality in patients returning to dialysis after allograft loss.
BACKGROUND
Although patients requiring dialysis after graft loss are increasing, data regarding the outcomes of patients on dialysis after graft loss are limited. We investigated the characteristics and risk factors for mortality in patients reinitiating dialysis after graft loss.


METHODS
A retrospective analysis was done for 292 patients who reinitiated dialysis after graft loss between 1985 and 2006.


RESULTS
The mean glomerular filtration rate (GFR) at dialysis reinitiation was 9.1 +/- 4.6 ml/min/1.73 m(2). Cardiovascular disease was the most common cause of death during the 67.4 +/- 50.6 months of follow-up. History of diabetes (HR 4.11, p = 0.02), new-onset diabetes after transplantation (HR 1.96, p = 0.03), Charlson comorbidity index score (HR 1.66, p = 0.03), and low serum albumin levels (HR 0.42, p = 0.03) were independent risk factors for mortality. However, GFR at dialysis reinitiation was not.


CONCLUSIONS
Comorbid conditions, new-onset diabetes after transplantation, and hypoalbuminemia predicted mortality in patients who returned to dialysis after graft failure.
Park
Jung Tak
JT
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yoo
Tae-Hyun
TH
Chang
Tae Ik
TI
Lee
Joo Hyun
JH
Lee
Dong Hyung
DH
Kim
Beom Seok
BS
Kang
Shin-Wook
SW
Lee
Ho Yung
HY
Kim
Myoung Soo
MS
Kim
Soon Il
SI
Kim
Yu Seun
YS
Choi
Kyu Hun
KH
D000328:Adult; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality; D002423:Cause of Death; D003920:Diabetes Mellitus / Q000401:mortality; D005260:Female; D006084:Graft Rejection / Q000276:immunology* / Q000401:mortality*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000276:immunology; D017211:Treatment Failure