An alkynyliodide cycloaddition strategy for the construction of iodoisoxazoles.
The thermally promoted cycloaddition between alkynyliodides and nitrile oxides is reported. The process offers excellent regioselectivity and a broad scope with respect to both the iodoalkynes and chloro-oximes. Further functionalization of the highly decorated iodoisoxazole motifs can be achieved via Suzuki cross-coupling.
Crossley
James A
JA
Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK.
Browne
Duncan L
DL