Host and parasite genomics, an Australasian perspective.
The last decade has seen rapid advances in the genetic technology that is allowing researchers to examine host-pathogen interactions at a whole organism level. The advent of 'affordable' post-genomic technology has opened up a world of proteomic, transcriptomic and metabolomic methodologies that have been utilized by research groups in the Australasian region to examine the hosts' response to parasitic infections. Significant contributions have been made to many areas of parasitic infections with particular strengths being in malaria vaccine development, genetic susceptibility to leishmaniasis, genomic and proteomic analysis of schistosomiasis and genetic determination of resistance to helminthes in domestic animals. This review highlights some of these studies that have made significant contributions to our knowledge of the pathogenesis of parasitic diseases with a particular emphasis placed on studies reported in the last couple of years.
Peacock
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Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, WA, Australia. cpeacock@cyllene.uwa.edu.au
D000818:Animals; D044362:Australasia; D035843:Biomedical Research / Q000639:trends; D023281:Genomics / Q000639:trends*; D054884:Host-Pathogen Interactions; D006801:Humans; D007896:Leishmaniasis / Q000235:genetics; D017780:Malaria Vaccines / Q000276:immunology; D010272:Parasitic Diseases / Q000235:genetics / Q000276:immunology* / Q000469:parasitology*; D010273:Parasitic Diseases, Animal / Q000235:genetics / Q000276:immunology* / Q000469:parasitology*; D012552:Schistosomiasis / Q000235:genetics
D017780:Malaria Vaccines