title: Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart.
abstract: Simulation of cardiac electrical function, and specifically, simulation aimed at understanding the mechanisms of cardiac rhythm disorders, represents an example of a successful integrative multiscale modeling approach, uncovering emergent behavior at the successive scales in the hierarchy of structural complexity. The goal of this article is to present a review of the integrative multiscale models of realistic ventricular structure used in the quest to understand and treat ventricular arrhythmias. It concludes with the new advances in image-based modeling of the heart and the promise it holds for the development of individualized models of ventricular function in health and disease.
authors.affiliation: CSEB 318, Johns Hopkins University, Baltimore, MD 21218.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Trayanova
authors.forename: Brock M
authors.initials: BM
authors.lastname: Tice