title: Guillian-Barré syndrome in high tetraplegia following acute respiratory illness.
abstract: METHODS
  A case report of a Guillain-Barré syndrome (GBS) variant presenting in a patient with a high cervical spinal cord injury (SCI).
  
  
  OBJECTIVE
  To illustrate a clinical presentation of GBS in an individual with chronic SCI.
  
  
  METHODS
  Vancouver General Hospital, Vancouver, BC, Canada.
  
  
  RESULTS
  A 31-year-old man with chronic C2 AIS B (American Spinal Injury Association Impairment Scale) SCI and diaphragmatic pacing presented with respiratory failure with sepsis. His sepsis resolved with antibiotic therapy, but he continued to have autonomic instability and was unable to be weaned off his ventilator. Concurrently he developed flaccidity and facial diplegia. Investigations including nerve conduction studies and cerebrospinal fluid analysis prompted a diagnosis of acute motor-sensory axonal neuropathy, a variant of Guillian-Barré syndrome. Owing to ongoing autonomic instability, he was treated with intravenous immunoglobulin. His autonomic dysfunction resolved and he regained some facial muscle function, but 6 months post injury he remained dysphagic and required 24-h ventilator support.
  
  
  CONCLUSIONS
  Careful neurological reassessment prompted the diagnosis of acute polyradiculoneuropathy following respiratory sepsis as the root cause of diaphragmatic pacer failure and autonomic instability.
authors.affiliation: Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Grant
authors.forename: N
authors.initials: N
authors.lastname: Briscoe
authors.forename: M
authors.initials: M
authors.lastname: Mezei
authors.forename: A
authors.initials: A
authors.lastname: Krassioukov
mesh_terms: D000208:Acute Disease; D000328:Adult; D020275:Guillain-Barre Syndrome / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011782:Quadriplegia / Q000150:complications* / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000150:complications* / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000150:complications* / Q000473:pathology / Q000503:physiopathology