Role of 7,8-dimethoxycoumarin in anti-secretary and anti-inflammatory action on pyloric ligation-induced gastritis in rats.
The present study was designed to investigate the effect of 7,8-dimethoxycoumarin (DMC) isolated from ethyl acetate extract of Citrus decumana peels on gastritis in rats. Isolation of 7,8-DMC from ethyl acetate extract of C. decumana peels was done by column and preparative thin layer chromatography using different solvents on polarity basis. Furthermore, effect of 7,8-DMC (50, 75, and 100 mg/kg, i.p.) in pyloric ligation-induced gastritis was studied in rats. The highest dose of 7,8-DMC showed significant decrease in the gastric volume, total acidity, ulcerative index, thiobarbituric acid reactive species levels, and myeloperoxidase activity, whereas there was an increase in the glutathione level. However, the lowest and medium doses did not produce significant results as compared to omeprazole and N-acetyl cysteine-treated groups. Compound 7,8-DMC (100 mg/kg) showed ameliorative effect on gastric inflammation and may be used as a therapeutic agent in the treatment of gastritis.
Sood
Shailja
S
Rayat Institute of Pharmacy, Ropar, Punjab, India. soodshalu@gmail.com
Muthuraman
Arunachalam
A
Gill
Naresh Singh
NS
Bali
Manoj
M
Sharma
Pritam Dev
PD
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D005756:Gastritis / Q000139:chemically induced*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009853:Omeprazole / Q000494:pharmacology; D011708:Pylorus / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D003374:Coumarins; C049928:7,8-dimethoxycoumarin; D009853:Omeprazole; D000111:Acetylcysteine