title: Exhaled nitric oxide, susceptibility and new-onset asthma in the Children's Health Study.
abstract: A substantial body of evidence suggests an aetiological role of inflammation, and oxidative and nitrosative stress in asthma pathogenesis. Exhaled nitric oxide fraction (F(eNO)) may provide a noninvasive marker of oxidative and nitrosative stress, and aspects of airway inflammation. We examined whether children with elevated F(eNO) are at increased risk for new-onset asthma. We prospectively followed 2,206 asthma-free children (age 7-10 yrs) who participated in the Children's Health Study. We measured F(eNO) and followed these children for 3 yrs to ascertain incident asthma cases. Cox proportional hazard models were fitted to examine the association between F(eNO) and new-onset asthma. We found that F(eNO) was associated with increased risk of new-onset asthma. Children in the highest F(eNO) quartile had more than a two-fold increased risk of new-onset asthma compared to those with the lowest quartile (hazard ratio 2.1, 95% CI 1.3-3.5). This effect did not vary with the child's history of respiratory allergic symptoms. However, the effect of elevated F(eNO) on new-onset asthma was most apparent among those without a parental history of asthma. Our results indicate that children with elevated F(eNO) are at increased risk for new-onset asthma, especially if they have no parental history of asthma.
authors.affiliation: Dept of Preventive Medicine, Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Bastain
authors.forename: T
authors.initials: T
authors.lastname: Islam
authors.forename: K T
authors.initials: KT
authors.lastname: Berhane
authors.forename: R S
authors.initials: RS
authors.lastname: McConnell
authors.forename: E B
authors.initials: EB
authors.lastname: Rappaport
authors.forename: M T
authors.initials: MT
authors.lastname: Salam
authors.forename: W S
authors.initials: WS
authors.lastname: Linn
authors.forename: E L
authors.initials: EL
authors.lastname: Avol
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: F D
authors.initials: FD
authors.lastname: Gilliland
mesh_terms: D001249:Asthma / Q000209:etiology* / Q000378:metabolism*; D002648:Child; D015331:Cohort Studies; D045853:Exhalation; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate; D007249:Inflammation; D008297:Male; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism*; D018384:Oxidative Stress; D016016:Proportional Hazards Models; D012135:Respiratory Sounds / Q000175:diagnosis*; D012923:Social Class; D011795:Surveys and Questionnaires
chemical_list: D009569:Nitric Oxide