Synthesis and antimicrobial activity of some novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines.
A new series of novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines 5a-d and 4-(1H-benz[d]imidazol-2yl)-3-alkyl-2,3-dihydro-1,3-thiazol-2-amine 8a-d has been synthesized by the cyclocondensation of 2-acetyl benzimidiazoles 4a-d and 2-bromo-1-(1-alkyl-1H-benzo[d]imidazol-2-yl)-1-ethanone 7a-d with thiourea respectively, and evaluated for their antibacterial and antifungal activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in these series exhibited antibacterial activity comparable to standard Streptomycin and Benzyl penicillin and antifungal activity against Fluconazole. All the newly synthesized compounds were characterized by their spectral data and further used to estimate their ability towards antimicrobial activity.
Malla Reddy
Vanga
V
Dr. Ch. Ravishanker Memorial Medicinal Chemistry Research Laboratory, College of Pharmaceutical Sciences, Kakatiya University, Warangal, India. vanga_mreddy@rediffmail.com
Ravinder Reddy
Kunduru
K
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
D000588:Amines; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D013890:Thiourea