title: Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.
abstract: OBJECTIVE
  To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.
  
  
  METHODS
  To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.
  
  
  RESULTS
  None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.
  
  
  CONCLUSIONS
  We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.
authors.affiliation: Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, University of Edinburgh and MRC Human Genetics Unit, Edinburgh, United Kingdom.
authors.forename: Albert
authors.initials: A
authors.lastname: Tenesa
authors.forename: Evropi
authors.initials: E
authors.lastname: Theodoratou
authors.forename: Farhat V N
authors.initials: FV
authors.lastname: Din
authors.forename: Susan M
authors.initials: SM
authors.lastname: Farrington
authors.forename: Roseanne
authors.initials: R
authors.lastname: Cetnarskyj
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Barnetson
authors.forename: Mary E
authors.initials: ME
authors.lastname: Porteous
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
authors.forename: Malcolm G
authors.initials: MG
authors.lastname: Dunlop
mesh_terms: D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis