title: Effect of transient acid stress on the proteome of intestinal probiotic Lactobacillus reuteri.
abstract: We report the acid tolerance response and changes in the level of protein expression of probiotic Lactobacillus reuteri subjected to transient (1.5 h) acid stress at pH 3.0. Sixteen acid-responsive proteins were identified by peptide mass fingerprinting including members of five broad functional categories: metabolism, transcription/translation, DNA replication/repair, transport and binding proteins, and pH homeostasis and stress responses. This work can provide some new and relevant information on the inducible mechanisms underlying the capacity of probiotic L. reuteri to tolerate acid stress.
authors.affiliation: Department of Biotechnology, SongDo Techno Park, Yeonsu-Gu, Incheon, 406-840, Korea. klee02@empal.com
authors.forename: KiBeom
authors.initials: K
authors.lastname: Lee
authors.forename: KyungBae
authors.initials: K
authors.lastname: Pi
mesh_terms: D015180:Electrophoresis, Gel, Two-Dimensional; D006863:Hydrogen-Ion Concentration; D052200:Limosilactobacillus reuteri / Q000187:drug effects / Q000378:metabolism*; D019936:Probiotics / Q000378:metabolism; D020543:Proteome / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D020543:Proteome