Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats.
OBJECTIVE
Evaluation of modafinil effects on the inhibitory avoidance task (IA).


METHODS
Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.


RESULTS
In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.


CONCLUSIONS
Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.
Moreira
Karin Monteiro
KM
Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
Ferreira
Tatiana Lima
TL
Hipolide
Debora Cristina
DC
Fornari
Raquel Vecchio
RV
Tufik
Sergio
S
Oliveira
Maria Gabriela Menezes
MG
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000150:complications*
D001559:Benzhydryl Compounds; D018696:Neuroprotective Agents; D000077408:Modafinil