Bioelectrical impedance analysis for evaluation of donor hepatic steatosis in living-donor liver transplantation.
OBJECTIVE
To assess whether bioelectrical impedance analysis (BIA) can be used to evaluate the degree of hepatic steatosis in potential living liver donors.


METHODS
From May 2008 to April 2009, BIA was measured in 302 living donor candidates. Correlations among body mass index (BMI; calculated as weight in kilograms divided by height in meters squared), total fatty changes at percutaneous needle liver biopsy, and BIA-derived fat composition were assessed.


RESULTS
The median (range) BIA-derived fat proportion was 19.4% (4.8%-35.3%), BMI was 24 (17-39), and hepatic steatosis at liver biopsy was 2% (0%-75%). Crude correlations were observed between BIA-derived fat proportion and hepatic steatosis (r(2) = 0.14; P = .000), between BMI and hepatic steatosis (r(2) = 0.27; P = .000), and between BMI and BIA-derived fat proportion (r(2) = .25; P = .000). Receiver operating characteristic curve analysis revealed that the area under the curve of BIA-derived fat proportion was smaller than that of BMI, and no significant cutoff value was identified.


CONCLUSIONS
These results suggest that BIA-derived fat composition alone cannot be used to accurately determine the degree of hepatic steatosis. However, a combination of BMI and BIA-derived fat composition may increase clinical ability to assess hepatic steatosis.
Hwang
S
S
Division of Hepatobiliay Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. shwang@amc.seoul.kr
Yu
Y D
YD
Park
G C
GC
Park
P J
PJ
Choi
Y I
YI
Choi
N K
NK
Kim
K W
KW
Song
G W
GW
Jung
D H
DH
Yun
J S
JS
Choi
S Y
SY
Lee
S G
SG
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001823:Body Composition; D015992:Body Mass Index; D017097:Electric Impedance; D005190:Family; D005234:Fatty Liver / Q000453:epidemiology; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007723:Korea; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D055815:Young Adult