Hereditary paraganglioma of the nasopharynx.
Head and neck paragangliomas are rare neuroendocrine tumors derived from neural crest cells of parasympathetic ganglia or the widely dispersed neuroendocrine cells of the head and neck region. Paragangliomas of the sinonasal tract and nasopharynx are rare. The clinicopathologic features of this unique example of a hereditary, nasopharyngeal paraganglioma, and selective entities that are included in its differential diagnosis are presented.
Said-Al-Naief
Nasser
N
School of Medicine, University of Alabama at Birmingham, 3556 North Pavilion 1802 6th Ave South, Birmingham, AL 35249-7331, USA. nasser@uab.edu
Ojha
Junu
J
D008949:Adenoma, Pleomorphic / Q000175:diagnosis; D018322:Angiofibroma / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000032:analysis; D002817:Chordoma / Q000175:diagnosis; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis; D006393:Hemangiopericytoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics*; D010235:Paraganglioma / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics*; D017354:Point Mutation; D013385:Succinate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase