title: Metabolic alterations of DHEA and cholesterol sulphates in the hair of patients with acne measured by liquid chromatography-mass spectrometry.
abstract: As the hormonal levels in scalp hair reflects the condition of skin appendage, the level of dehydroepiandrosterone-3-sulphate (DHEAS) and cholesterol sulphate (CS) was evaluated in scalp hair obtained from patients with acne. The hair samples were extracted by alkaline solution and were analysed by liquid chromatography-mass spectrometry coupled to column switching system. The levels of DHEAS in scalp hair of women with acne were higher (P < 0.001) than controls, while the levels of CS in scalp hair of women and men with acne were higher (P < 0.001) than both control subjects. Increased hair levels of both DHEAS and CS could indicate acne development because of its direct action or stimulatory effect on local enzyme activity. It may be also helpful to understand the pathogenesis of acne based on follicular retention hyperkeratosis and increased sebum production of both steroid sulphates.
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Cho
authors.forename: Man Ho
authors.initials: MH
authors.lastname: Choi
authors.forename: Woo Y
authors.initials: WY
authors.lastname: Sim
authors.forename: Won-Yong
authors.initials: WY
authors.lastname: Lee
authors.forename: Bong Chul
authors.initials: BC
authors.lastname: Chung
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D000328:Adult; D016022:Case-Control Studies; D002788:Cholesterol Esters / Q000378:metabolism*; D002853:Chromatography, Liquid; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood / Q000378:metabolism*; D005260:Female; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D002788:Cholesterol Esters; D019314:Dehydroepiandrosterone Sulfate; C007045:cholesteryl sulfate