CD3+ and BLA.36+ cells do not occur in the epidermis and adnexal epithelia of normal equine skin.
Summary A small population of resident T lymphocytes is present in the healthy human and murine epidermis. However, resident epidermal lymphocytes have not been reported in normal skin of the horse. Skin biopsy specimens from the normal skin of 27 horses were examined histologically and immunohistochemically for the presence of lymphocytes, CD3+ cells and BLA.36+ cells in epidermis and adnexal epithelia. All examinations were negative. It appears that lymphocytes occur rarely, if at all, in the epidermis and adnexal epithelia of normal horse skin. Hence, the presence of lymphocytes in these structures should be considered abnormal.
Tranchina
M M
MM
Department of Clinical Sciences; and Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, New York, USA.
Scott
D W
DW
McDonough
S P
SP
D000818:Animals; D017252:CD3 Complex / Q000378:metabolism*; D000078404:Epidermal Cells; D004847:Epithelial Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D006736:Horses / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
D017252:CD3 Complex; D009363:Neoplasm Proteins