Self-assembled monolayers of silver nanoparticles firmly grafted on glass surfaces: low Ag+ release for an efficient antibacterial activity.
A two-step, easy synthetic strategy in solution has been optimized to prepare authentic monolayers of silver nanoparticles (NP) on MPTS-modified glass surfaces, that were investigated by AFM imaging and by quantitative silver determination techniques. NP in the monolayers remain firmly grafted (i.e. not released) when the surfaces are exposed to air, water or in the physiological conditions mimicked by phosphate saline buffer, as UV-Vis spectroscopy and AFM studies demonstrate. About 15% silver release as Ag(+) ions has been found after 15days when the surfaces are exposed to water. The released silver cations are responsible of an efficient local microbicidal activity against Escherichia coli and Staphylococcus aureus bacterial strains.
Pallavicini
Piersandro
P
Laboratorio di Nanochimica, Dipartimento di Chimica Generale, Università di Pavia, viale Taramelli 12-27100 Pavia, Italy. piersandro.pallavicini@unipv.it
Taglietti
Angelo
A
Dacarro
Giacomo
G
Diaz-Fernandez
Yuri Antonio
YA
Galli
Matteo
M
Grisoli
Pietro
P
Patrini
Maddalena
M
Santucci De Magistris
Giorgio
G
Zanoni
Robertino
R
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004355:Drug Stability; D005898:Glass / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D012834:Silver