title: Prognostic value of serum acute-phase proteins in dogs with parvoviral enteritis.
abstract: OBJECTIVE
  To evaluate the acute-phase protein response in dogs with parvoviral enteritis as predictor of the clinical outcome.
  
  
  METHODS
  Canine parvovirus infection was diagnosed based on the compatible clinical findings and confirmed by the canine parvovirus antigen test in 43 dogs of less than six months of age. Blood samples for complete blood cell count and acute-phase proteins (C-reactive protein, haptoglobin, ceruloplasmin and albumin) were collected before treatment. Twenty-three dogs died during or after treatment (non-survival) and the rest recovered (survival). Five healthy dogs were enrolled as control.
  
  
  RESULTS
  Serum C-reactive protein, ceruloplasmin and haptoglobin levels in dogs with parvoviral enteritis were higher (P<0·001, P<0·01 and P<0·001, respectively), but serum albumin was lower (P<0·001) than those in controls. Mean C-reactive protein and ceruloplasmin values in non-survival were higher (P<0·01) than those for survival dogs. C-reactive protein was found to be superior to ceruloplasmin, haptoglobin and albumin for distinguishing survival from non-survival dogs. Values higher than 92·4 mg/l for C-reactive protein had a sensitivity of 91% to predict mortality.
  
  
  CONCLUSIONS
  The magnitude of the increase in serum acute-phase proteins in dogs with parvoviral enteritis could be a useful indicator of the prognosis of the disease. In acute-phase proteins, C-reactive protein is a potent predictor of mortality in dogs with parvoviral enteritis.
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, Uludag University, 16059 Bursa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kocaturk
authors.forename: S
authors.initials: S
authors.lastname: Martinez
authors.forename: O
authors.initials: O
authors.lastname: Eralp
authors.forename: A
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: J
authors.initials: J
authors.lastname: Ceron
authors.forename: Z
authors.initials: Z
authors.lastname: Yilmaz
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood* / Q000401:mortality; D004285:Dogs; D004751:Enteritis / Q000097:blood / Q000401:mortality / Q000662:veterinary*; D005260:Female; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000401:mortality / Q000662:veterinary*; D017993:Parvovirus, Canine; D011379:Prognosis
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers