Newly described translocation (18;19)(q23;q13.2) in abdominal wall soft-tissue tumor resembling Ewing sarcoma/primitive neuroectodermal tumor.
From a morphologic standpoint, Ewing sarcoma (EWS) is one of a number of pediatric malignancies that are characterized by sheets of small, round, blue cells. Ewing sarcoma can usually be differentiated from other small round blue cell tumors by the presence of a gene rearrangement having a consistent breakpoint within the Ewing sarcoma gene (EWSR1) at 22q12. Although the most common translocation partner is FLI1, located at 11q24, there is a growing list of alternate rearrangements involving different loci. We describe the first example of a soft-tissue sarcoma morphologically and immunohistochemically similar to Ewing sarcoma, but with a novel t(18;19)(q23;q13.2).
Riccardi
Gina F
GF
Department of Orthopedics, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Stein
Constance
C
de la Roza
Gustavo
G
Damron
Timothy A
TA
D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D017599:Neuroectodermal Tumors / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D051789:Proto-Oncogene Protein c-fli-1 / Q000235:genetics; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; C078433:FLI1 protein, human; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins