title: Sonoelastography in the diagnosis of malignant and benign breast lesions: initial clinical experiences.
abstract: OBJECTIVE
  This prospective study aimed to compare sonoelastography, B-mode ultrasonography, and mammography in terms of their ability to distinguish benign from malignant breast lesions. We also assessed how the diagnostic value of sonoelastography differs between palpable and clinically occult lesions.
  
  
  METHODS
  Evaluation revealed a total of 97 lesions (66 benign; 31 malignant) without histological confirmation at the time of the initial examination. The sensitivity, specificity, positive (PPV) and negative predictive value (NPV) as well as efficiency were calculated. These parameters were separately assessed for palpable lesions and for non-palpable lesions. We subsequently compared these results.
  
  
  RESULTS
  Sonography had a sensitivity of 97% and a specificity of 82% (PPV: 71 %, NPV: 98%, efficiency: 87%). For mammography, the respective figures were 84% and 89% (PPV: 79%, NPV: 92%, efficiency: 88%). Sonoelastography had a sensitivity of 71% and a specificity of 48% (PPV: 39%, NPV: 78%, efficiency: 56%). The combination of sonography and sonoelastography yielded a sensitivity of 100% and a specificity of 38% (PPV: 43%, NPV: 100%, efficiency: 58%). The sensitivity and specificity were not statistically different between the groups of palpable and non-palpable lesions.
  
  
  CONCLUSIONS
  Sonoelastography is easily performed and not very time-consuming. Used by itself, the method is not more efficacious than alternative techniques. When used in conjunction with B-mode ultrasonography, the latter's sensitivity was increased, albeit at the expense of specificity.
authors.affiliation: Gynecology & Obstetrics, Ernst-Moritz-Arndt University Greifswald, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Hatzung
authors.forename: S
authors.initials: S
authors.lastname: Grunwald
authors.forename: M
authors.initials: M
authors.lastname: Zygmunt
authors.forename: A-A
authors.initials: AA
authors.lastname: Geaid
authors.forename: P-O
authors.initials: PO
authors.lastname: Behrndt
authors.forename: R
authors.initials: R
authors.lastname: Isermann
authors.forename: T
authors.initials: T
authors.lastname: Kohlmann
authors.forename: R
authors.initials: R
authors.lastname: Ohlinger
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000473:pathology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010212:Papilloma / Q000000981:diagnostic imaging / Q000473:pathology; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*