title: [Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues].
abstract: OBJECTIVE
  To determine the role of fragile histidine triad (FHIT) and MDM2 in carcinogenesis of oral submucous fibrosis (OSF).
  
  
  METHODS
  The expression of FHIT and MDM2 was examined by immunohistochemical S-P method in 44 OSF cases, 15 canceration tissues of OSF, and 10 normal oral mucosa tissues.
  
  
  RESULTS
  The expression of FHIT was positive in the normal oral mucosa epithelium. The positive expression of FHIT decreased in the OSF and canceration tissues of the OSF.The rate of FHIT positive expression was significantly lower in canceration tissues of OSF than that of the OSF (P < 0.05). The expression of MDM2 was negative in normal oral mucosa epithelium. The positive expression of MDM2 increased in the OSF and canceration tissues of the OSF, and the rate of MDM2 positive expression was significantly higher in the canceration tissues of OSF than that of the OSF (P < 0.05).
  
  
  CONCLUSIONS
  The loss of FHIT and over-expression of MDM2 may play an important role in the carcinogenesis of OSF.
authors.affiliation: Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410078, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Yin
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wen
authors.forename: Yuling
authors.initials: Y
authors.lastname: Han
authors.forename: Yijun
authors.initials: Y
authors.lastname: Gao
authors.forename: Zhangui
authors.initials: Z
authors.lastname: Tang
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009914:Oral Submucous Fibrosis / Q000378:metabolism*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics / Q000378:metabolism*; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D051736:Proto-Oncogene Proteins c-mdm2; D000099170:Bis(5'-adenosyl)triphosphatase; C497206:MDM2 protein, human