title: Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells.
abstract: This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.
authors.affiliation: Infertility Clinic, Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: JongYeob
authors.initials: J
authors.lastname: Choi
authors.forename: MinWha
authors.initials: M
authors.lastname: Jo
authors.forename: EunYoung
authors.initials: E
authors.lastname: Lee
authors.forename: DooSeok
authors.initials: D
authors.lastname: Choi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism / Q000473:pathology*; D008247:Lysosomes / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2