title: Synthesis and characterization of quaternized beta-chitin.
abstract: Water-soluble 2'-O-hydroxypropyltrimethylammoniumchitin chloride (2'-O-HTACCt) was prepared directly from beta-chitin and 3-chloro-2-hydroxypropyltrimethylammonium chloride (CTA) in basic medium. The effect of alkali concentration, reaction temperature, reaction time, and dosage of CTA on yield and degree of substitution (DS) of 2'-O-HTACCt were studied. These quaternized chitin derivatives were characterized by FTIR and (1)H NMR spectroscopy, conductometric titration, and elemental analysis methods. Research results indicate that beta-chitin can react directly with CTA to produce a water-soluble 2'-O-HTACCt derivative with a high DS. The optimal preparation conditions were determined to be 35-40 wt% (aq NaOH), 40 degrees C (reaction temperature), 6h (reaction time), and 4 (molar ratio of CTA to beta-chitin unit).
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen, PR China.
authors.forename: Qunying
authors.initials: Q
authors.lastname: Chen
authors.forename: Yiguang
authors.initials: Y
authors.lastname: Wu
authors.forename: Yitao
authors.initials: Y
authors.lastname: Pu
authors.forename: Zongkun
authors.initials: Z
authors.lastname: Zheng
authors.forename: Chunzhi
authors.initials: C
authors.lastname: Shi
authors.forename: Xinzheng
authors.initials: X
authors.lastname: Huang
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002686:Chitin / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D020005:Propanols / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D020005:Propanols; D000644:Quaternary Ammonium Compounds; D014867:Water; D002686:Chitin; C496948:(3-chloro-2-hydroxypropyl)trimethylammonium chloride