title: Effect of maternal body mass index on in vitro response to tocolytics in term myometrium.
abstract: OBJECTIVE
  We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics.
  
  
  METHODS
  Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI < or =29.9 (26.3 +/- 1.3; n = 7), 30-34.9 (31.8 +/- 1.2; n = 16), and > or = 35 (39.5 +/- 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10(-10) to 10(-5) mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test.
  
  
  RESULTS
  Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI.
  
  
  CONCLUSIONS
  BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chiossi
authors.forename: Maged M
authors.initials: MM
authors.lastname: Costantine
authors.forename: Ancizar
authors.initials: A
authors.lastname: Betancourt
authors.forename: Gary D V
authors.initials: GD
authors.lastname: Hankins
authors.forename: Monica
authors.initials: M
authors.lastname: Longo
authors.forename: George R
authors.initials: GR
authors.lastname: Saade
authors.forename: Egle
authors.initials: E
authors.lastname: Bytautiene
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001706:Biopsy; D015992:Body Mass Index; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects / Q000473:pathology; D009543:Nifedipine / Q000494:pharmacology*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D015149:Tocolytic Agents; D009543:Nifedipine; D007213:Indomethacin