title: Enhanced drug loading in polymerized micellar cargo.
abstract: A new drug carrier system based on self-assembly and polymerization of polydiacetylenic amphiphiles is described. Although classical amphiphiles can help in solubilizing hydrophobic molecules upon self-arrangement into a variety of nanometric structures, a greater effect on drug loading was observed for our polymerized micelles as compared to the non-polymerized analogues. This permitted higher aqueous solubilization of lipophilic drugs with low micelle concentration. (14)C labeling of a model drug on one side and of the amphiphile on the other side permitted assessment, after intravenous injection, of biodistribution and excretion profiles of the drug cargo.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Ogier
authors.forename: Thomas
authors.initials: T
authors.lastname: Arnauld
authors.forename: Géraldine
authors.initials: G
authors.lastname: Carrot
authors.forename: Antoine
authors.initials: A
authors.lastname: Lhumeau
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Delbos
authors.forename: Claire
authors.initials: C
authors.lastname: Boursier
authors.forename: Olivier
authors.initials: O
authors.lastname: Loreau
authors.forename: Francois
authors.initials: F
authors.lastname: Lefoulon
authors.forename: Eric
authors.initials: E
authors.lastname: Doris
mesh_terms: D000818:Animals; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D053279:Polyynes / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility
chemical_list: D008823:Micelles; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene