A selective, cell-permeable fluorescent probe for Al3+ in living cells.
The synthesis and evaluation of a novel Schiff-base fluorescent probe L for detection of Al(3+) are described. The structure of L was determined by X-ray and other spectroscopic data. The fluorescent spectra changes and microscopy images show that indicator L is highly selective for Al(3+) not only in abiotic systems but also in living cells. Other metal ions failed to respond. The new probe could be used as an efficient tool for Al(3+) monitoring in the environment and biological systems.
Wang
Lina
L
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Qin
Wenwu
W
Tang
Xiaoliang
X
Dou
Wei
W
Liu
Weisheng
W
Teng
Qingfeng
Q
Yao
Xiaojun
X
D000535:Aluminum / Q000032:analysis* / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D002463:Cell Membrane Permeability; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020014:K562 Cells; D008958:Models, Molecular; D008968:Molecular Conformation
D002412:Cations; D005456:Fluorescent Dyes; D000535:Aluminum