title: Sample design and cohort selection in the Hispanic Community Health Study/Study of Latinos.
abstract: OBJECTIVE
  The Hispanic Community Health Study (HCHS)/Study of Latinos (SOL) is a multicenter, community-based cohort study of Hispanic/Latino adults in the United States. A diverse participant sample is required that is both representative of the target population and likely to remain engaged throughout follow-up. The choice of sample design, its rationale, and benefits and challenges of design decisions are described in this study.
  
  
  METHODS
  The study design calls for recruitment and follow-up of a cohort of 16,000 Hispanics/Latinos 18-74 years of age, with 62.5% (10,000) over 44 years of age and adequate subgroup sample sizes to support inference by Hispanic/Latino background. Participants are recruited in community areas surrounding four field centers in the Bronx, Chicago, Miami, and San Diego. A two-stage area probability sample of households is selected with stratification and oversampling incorporated at each stage to provide a broadly diverse sample, offer efficiencies in field operations, and ensure that the target age distribution is obtained.
  
  
  CONCLUSIONS
  Embedding probability sampling within this traditional, multisite cohort study design enables competing research objectives to be met. However, the use of probability sampling requires developing solutions to some unique challenges in both sample selection and recruitment, as described here.
authors.affiliation: Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA. lisa_lavange@unc.edu
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Lavange
authors.forename: William D
authors.initials: WD
authors.lastname: Kalsbeek
authors.forename: Paul D
authors.initials: PD
authors.lastname: Sorlie
authors.forename: Larissa M
authors.initials: LM
authors.lastname: Avilés-Santa
authors.forename: Robert C
authors.initials: RC
authors.lastname: Kaplan
authors.forename: Janice
authors.initials: J
authors.lastname: Barnhart
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
authors.forename: Aida
authors.initials: A
authors.lastname: Giachello
authors.forename: David J
authors.initials: DJ
authors.lastname: Lee
authors.forename: John
authors.initials: J
authors.lastname: Ryan
authors.forename: Michael H
authors.initials: MH
authors.lastname: Criqui
authors.forename: John P
authors.initials: JP
authors.lastname: Elder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002140:California; D002641:Chicago; D015331:Cohort Studies; D003151:Community Health Centers / Q000191:economics / Q000458:organization & administration; D004641:Emigration and Immigration; D005260:Female; D005378:Financial Support; D005431:Florida; D006306:Health Surveys; D006630:Hispanic or Latino / Q000208:ethnology; D006801:Humans; D008297:Male; D017058:Mexican Americans / Q000208:ethnology; D008875:Middle Aged; D009519:New York City; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D012494:Sampling Studies; D011795:Surveys and Questionnaires; D055815:Young Adult