title: Design and synthesis of novel isoxazole-based HDAC inhibitors.
abstract: A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn(2+)-binding group in order to check its participation in the coordinating process.
authors.affiliation: Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy. paola.conti@unimi.it
authors.forename: Paola
authors.initials: P
authors.lastname: Conti
authors.forename: Lucia
authors.initials: L
authors.lastname: Tamborini
authors.forename: Andrea
authors.initials: A
authors.lastname: Pinto
authors.forename: Laura
authors.initials: L
authors.lastname: Sola
authors.forename: Roberta
authors.initials: R
authors.lastname: Ettari
authors.forename: Ciro
authors.initials: C
authors.lastname: Mercurio
authors.forename: Carlo
authors.initials: C
authors.lastname: De Micheli
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D056572:Histone Deacetylase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D007527:Isoenzymes; D007555:Isoxazoles; D006655:Histone Deacetylases