title: Relationship between H.Pylori infection and clinicopathological features and prognosis of gastric cancer.
abstract: BACKGROUND
  Aimed to assess the relationship between H.Pylori and the clinicopathological features and prognosis of gastric cancer by quantitative detection of H.Pylori.
  
  
  METHODS
  157 patients were enrolled, all patients had a record of clinicopathological parameters. Specimens including the tumor and non-neoplastic were detected for H.Pylori by Real-Time PCR and analyzed clinical data retrospectively. Variables independently affecting prognosis were investigated by means of multivariate analysis using the Cox proportional hazards model.
  
  
  RESULTS
  H.Pylori infection was greater in non-neoplastic tissue than the tumor tissue (p < 0.05), H.Pylori infection and its copies were related to the tumor site and N staging (p < 0.05). Overall survival (OS) in all 157 patients has no correlation with the H.Pylori infection status (p = 0.715). As to the patients who underwent a curative surgery, relapse-free survival (RFS) has no correlation with the H.Pylori infection status (p = 0.639). Among the H.Pylori positive patients, OS and RFS of those with higher copies were longer than in patients with low copies, but there was no significant statistical difference.
  
  
  CONCLUSIONS
  H.Pylori infection status and its copies were related to N staging. The OS and RFS in patients with positive H.Pylori status has no significant difference from the patients with negative H.Pylori status.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Qiu
authors.forename: Li-Yi
authors.initials: LY
authors.lastname: Zhang
authors.forename: Rajiv-Prasad
authors.initials: RP
authors.lastname: Keshari
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Wang
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhou
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: You-Qin
authors.initials: YQ
authors.lastname: Zhan
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000382:microbiology* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology* / Q000473:pathology; D015996:Survival Rate
chemical_list: D004279:DNA, Viral