Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds.
Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure-activity relationship study. The result against 3T3-L1 adipocyte indicated that the C-glucoside part of 1 is unconcerned in its activity when tested in vitro and the main structure responsible for its activity was the isoflavone moiety.
Kato
Eisuke
E
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-8589, Japan. eikato@chem.agr.hokudai.ac.jp
Kawabata
Jun
J
D041721:3T3-L1 Cells; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy; D005947:Glucose / Q000378:metabolism*; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D007529:Isoflavones / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice
D005960:Glucosides; D007529:Isoflavones; D005947:Glucose; C033607:puerarin