[Eosinophil: a new effector of innate immunity?].
The eosinophil leukocyte has long been considered as a second class cell. It appears now that its functions extend far beyond solely the release of cytotoxic mediators involved in a protective role in some parasitic infections or in pathological manifestations during allergic diseases. The recent demonstration that eosinophils express innate immune receptors (TLR, gdTCR) and mediators (a-defensins), in addition to the numerous receptors involved in adaptive immunity, confers to eosinophils the potential to directly recognize danger signals including pathogens. Thus, both such a functional plasticity together with its strategic tissue localization indicate that eosinophils likely play a previously unsuspected role in anti-infectious response.
Driss
Virginie
V
Université Lille 2, Institut Pasteur de Lille, France.
Legrand
Fanny
F
Loiseau
Sylvie
S
Capron
Monique
M
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D001717:Birds; D003594:Cytoplasmic Granules / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D010272:Parasitic Diseases / Q000276:immunology; D010802:Phylogeny; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D052736:Rous sarcoma virus / Q000276:immunology; D001357:Sarcoma, Avian / Q000821:virology; D051193:Toll-Like Receptors / Q000276:immunology
D016692:Receptors, Antigen, T-Cell, gamma-delta; D051193:Toll-Like Receptors