Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease.
OBJECTIVE
Body mass index (BMI) is closely associated with mortality in chronic obstructive pulmonary disease (COPD). Systemic inflammation has been suggested as one of the mechanisms of malnutrition in COPD. This study investigated the relationships of clinical variables and inflammatory biomarkers with BMI in COPD in an aging population.


METHODS
Baseline levels of serum biomarkers were determined for 69 patients with stable male COPD. Multivariate logistic regression was used to evaluate associations between clinical variables, including emphysema scores, and biomarkers with BMI.


RESULTS
Twenty eight patients were categorized as low BMI (<20 kg/m2). BMI was inversely correlated with serum α1-antitrypsin (α1-AT) concentration and emphysema scores, and was positively correlated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). Multivariate logistic regression analysis showed that α1-AT was independently associated with BMI.


CONCLUSIONS
Low BMI was associated with the severity of emphysema and systemic inflammation reflected by elevated α1-AT level.
Higashimoto
Yuji
Y
Department of Rehabilitation Medicine, Kinki University School of Medicine, Osaka, Japan. yhigashi@med.kindai.ac.jp
Yamagata
Toshiyuki
T
Honda
Noritsugu
N
Satoh
Ryuji
R
Sano
Hiroyuki
H
Iwanaga
Takashi
T
Miyhara
Takayuki
T
Muraki
Masato
M
Tomita
Katsuyuki
K
Tohda
Yuji
Y
Fukuda
Kanji
K
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000503:physiopathology*; D012720:Severity of Illness Index
D015415:Biomarkers