title: Association of weight change in different periods of adulthood with risk of type 2 diabetes in Japanese men and women: the Japan Public Health Center-Based Prospective Study.
abstract: BACKGROUND
  Few studies have examined the impact of weight change in different periods of lifetime on type 2 diabetes risk, and the association of weight loss with type 2 diabetes is unclear. We prospectively investigated the association of weight change since age 20 y and that during middle-to-late adulthood with the incidence of type 2 diabetes.
  
  
  METHODS
  Subjects were 52,014 men and women aged 45-75 y who participated in the Japan Public Health Center-Based Prospective Study and had no history of diabetes. ORs of self-reported physician-diagnosed type 2 diabetes for weight change between age 20 y and baseline survey (mean age 50.6 y) and during 5 y between baseline and second surveys were estimated using logistic regression analysis.
  
  
  RESULTS
  During the 5-year period following 5-year survey, 989 newly diagnosed cases of type 2 diabetes were self-reported. Weight gain from age 20 y was associated with an increased risk of type 2 diabetes. The multivariate-adjusted OR (95% CI) for a weight gain of ≥5 kg versus a stable weight were 2.61 (2.11 to 3.23) in men and 2.56 (1.95 to 3.35) in women. A weight gain of ≥5 kg over the 5-y following the baseline survey was also associated with an increased risk in women. No association with weight loss was observed for either period.
  
  
  CONCLUSIONS
  These results suggest that long-term weight gain from early adulthood to middle-age increases risk of type 2 diabetes in men and women and that risk is further enhanced by weight gain in later life in women.
authors.affiliation: Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Toyama 1-21-1, Shinjuku-ku, Tokyo, Japan. nanri@ri.ncgm.go.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Nanri
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizoue
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
authors.forename: Manami
authors.initials: M
authors.lastname: Inoue
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D016017:Odds Ratio; D011159:Population Surveillance; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D015430:Weight Gain; D015431:Weight Loss; D055815:Young Adult