Molecular basis and current treatment for alcoholic liver disease.
Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the liver, followed by liver fibrosis and cirrhosis. This review comprises a broad approach of alcohol use disorders, and a more specific assessment of the pathophysiologic molecular basis, and genetics, as well as clinical presentation and current modalities of treatment for alcoholic liver disease.
Miranda-Mendez
Alejandra
A
Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Jalisco, Mexico. alemirme@hotmail.com
Lugo-Baruqui
Alejandro
A
Armendariz-Borunda
Juan
J
D002423:Cause of Death; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000235:genetics* / Q000401:mortality / Q000628:therapy*; D014944:World Health Organization