title: Congenital malformation of fetus in a pregnancy following spontaneous ovulation in a case of premature ovarian failure.
abstract: Premature ovarian failure (POF), that is, amenorrhea before 40 years of age can be attributed to a variety of etiologies. Approximately 1% of women before 30 years are diagnosed with POF. Spontaneous ovulation leading to pregnancy in POF is even a rarer entity. We report a case where congenital malformations were diagnosed in a fetus following spontaneous ovulation in a case of POF. A 33-year-old woman presented to our center with primary infertility. On complete work up, she was diagnosed with POF and conceived with hormone replacement therapy and donor oocyte program. She delivered a healthy female baby through caesarean section. The patient reviewed later with amenorrhea of 40 days and pregnancy was confirmed. However, during antenatal follow-up congenital anomalies in fetus were diagnosed sonographically. The decision for termination of pregnancy was taken. To conclude, we recommend large-scale retrospective analysis that would define medical guidelines in cases of pregnancy following spontaneous ovulation in POF.
authors.affiliation: Department of Reproductive Medicine, GG Hospital, Fertility Research Centre, Chennai, Tamilnadu, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Selvaraj
authors.forename: Kamala
authors.initials: K
authors.lastname: Selvaraj
authors.forename: Megha
authors.initials: M
authors.lastname: Agrawal
authors.forename: Gunjan
authors.initials: G
authors.lastname: Singh