Array comparative genomic hybridization analysis revealed four genomic prognostic biomarkers for primary gastric cancers.
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification of four prognostic loci in this study: 6q21 (harboring FOXO3A; previously FKHRL1), 9q32 (UGCG), 17q21.1 approximately q21.2 (CASC3), and 17q21.32 (HOXB3 through HOXB9). If any one of these four loci was deleted, the prognosis of the patient was significantly worse (P = 0.0019). This was true even for advanced tumors (stage IIIA, IIB, or IV, n = 39) (P = 0.0113), whereas only 1 of the 17 patients with less advanced tumors (stage IA, IB, or II; n = 17) died of disease after surgery. Multivariate analysis according to the status of four BACs or pathological stage based on the Japanese Classification of Gastric Carcinoma (stages IA, IB, and II vs. stages IIIA, IIIB, and IV) demonstrated that the BAC clone status was also an independent prognostic factor (P = 0.006). These findings may help predict which patients with malignant potential need more intensive therapy, or may point to new therapeutic approaches especially for advanced tumors. The parameter here termed the integrated genomic prognostic biomarker may therefore be of clinical utility as a prognostic biomarker.
Tomioka
Nobumoto
N
Department of General Surgery, Hokkaido University Graduate School of Medicine, N-15 W-7 Kita-ku, Sapporo, Japan. ntomioka@sapporo-shaho.jp
Morita
Keiko
K
Kobayashi
Nozomi
N
Tada
Mitsuhiro
M
Itoh
Tomoo
T
Saitoh
Soichiro
S
Kondo
Masao
M
Takahashi
Norihiko
N
Kataoka
Akihiko
A
Nakanishi
Kazuaki
K
Takahashi
Masato
M
Kamiyama
Toshiya
T
Ozaki
Michitaka
M
Hirano
Takashi
T
Todo
Satoru
S
D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000235:genetics*; D002874:Chromosome Mapping; D022202:Chromosomes, Artificial, Bacterial; D017931:DNA Primers; D015894:Genome, Human; D006801:Humans; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics*
D014408:Biomarkers, Tumor; D017931:DNA Primers