title: New synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of in situ generated nitrile imines and benzyne.
abstract: A new synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min, affording the corresponding N(1)-C(3) disubstituted indazoles in moderate to excellent yields.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
authors.forename: Christian
authors.initials: C
authors.lastname: Spiteri
authors.forename: Steve
authors.initials: S
authors.lastname: Keeling
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D007097:Imines; D007191:Indazoles; D009570:Nitriles; C524146:benzyne