title: Resting heart rate and metabolic syndrome in patients with diabetes and coronary artery disease in bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial.
abstract: The relation between the metabolic syndrome (MetS) and resting heart rate (rHR) in patients with diabetes and coronary artery disease is unknown. The authors examined the cross-sectional association at baseline between components of the MetS and rHR and between rHR and left ventricular ejection fraction in the population from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) randomized clinical trial. The mean rHR in the MetS group was significantly higher than in those without (68.4+/-12.3 vs 65.6+/-11.8 beats per min, P=.0017). The rHR was higher (P<.001 for trend) with increasing number of components for MetS. Linear regression analyses demonstrated that as compared to individuals without MetS, rHR was significantly higher in participants with MetS (regression coefficient, 2.9; P=.0015). In patients with type 2 diabetes and coronary artery disease, the presence of higher rHR is associated with increasing number of criteria of MetS and the presence of ventricular dysfunction.
authors.affiliation: Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90048, USA. jamal.rana@cshs.org
authors.forename: Jamal S
authors.initials: JS
authors.lastname: Rana
authors.forename: Regina M
authors.initials: RM
authors.lastname: Hardison
authors.forename: Rodica
authors.initials: R
authors.lastname: Pop-Busui
authors.forename: Maria M
authors.initials: MM
authors.lastname: Brooks
authors.forename: Teresa L Z
authors.initials: TL
authors.lastname: Jones
authors.forename: Richard W
authors.initials: RW
authors.lastname: Nesto
authors.forename: Martial G
authors.initials: MG
authors.lastname: Bourassa
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006305:Health Status Indicators; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D012146:Rest; D012307:Risk Factors; D013223:Statistics as Topic; D013318:Stroke Volume; D016277:Ventricular Function, Left