Association of periodontitis and metabolic syndrome in the Baltimore Longitudinal Study of Aging.
OBJECTIVE
Metabolic syndrome (MetS) comprises central obesity, insulin resistance, hypertension and dyslipidemia, interrelated metabolic risk factors for diabetes and cardiovascular disease. A state of low-grade systemic inflammation may underlie this constellation of risk factors. Chronic inflammatory conditions, such as periodontal disease, may contribute to systemic inflammation and development of MetS. This study examines the association of periodontitis with MetS with and without consideration of systemic inflammatory status.


METHODS
The association of alveolar bone loss (none/slight vs moderate/severe) determined from panoramic radiographs and MetS parameters were analyzed using logistic regression, adjusting for age, sex, ethnicity, and smoking in 112 men and 78 women (mean+/-SD age 56.7+/-13.3 and 60.0+/-12.1, respectively) participating in the Baltimore Longitudinal Study of Aging.


RESULTS
Participants with radiographic evidence of moderate to advanced alveolar bone loss were significantly more likely to have MetS than those with minimal or no bone loss (OR 2.61, 95% CI 1.1-6.1, p<0.05). No significant differences in systemic inflammation were found between periodontal groups.


CONCLUSIONS
The association of alveolar bone loss to MetS is consistent with the hypothesis that destructive periodontal disease may contribute to the development of MetS and elevations in systemic inflammation. Longitudinal studies are necessary to clarify the role of periodontal disease in the development of MetS and conditions associated with chronic inflammation.
Nesbitt
Mark J
MJ
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
Reynolds
Mark A
MA
Shiau
Harlan
H
Choe
Kyong
K
Simonsick
Eleanor M
EM
Ferrucci
Luigi
L
D000328:Adult; D000368:Aged; D000375:Aging; D016301:Alveolar Bone Loss / Q000453:epidemiology*; D015142:Baltimore / Q000453:epidemiology; D055113:Chronic Periodontitis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D012307:Risk Factors