title: Outcomes of intensive surveillance after resection of hepatic colorectal metastases.
abstract: BACKGROUND
  The impact of computed tomography (CT)-based follow-up for the detection of resectable disease recurrence following surgery for colorectal liver metastases (CRLM) was evaluated.
  
  
  METHODS
  Some 705 patients undergoing resection of CRLM between January 1993 and March 2007 were included. Surveillance comprised 3-monthly CT (thorax, abdomen and pelvis) in the first 2 years after surgery, 6 monthly for 3 years and annually from years 6 to 10. Survival differences following recurrence between patients managed surgically and palliatively were determined, and the cost was calculated.
  
  
  RESULTS
  Five-year disease-free and overall survival rates were 28.3 and 32.3 per cent respectively. Of 402 patients who developed recurrence within 2 years, 88 were treated with liver resection alone and 36 with lung and/or liver resection. Their 5-year overall survival rates were 31 and 30 per cent respectively, compared with 3.9 per cent in 278 patients managed palliatively (P < 0.001). For each 3-month interval during the first year of follow-up, patients with recurrence treated surgically had better overall survival than those treated palliatively. The cost of surveillance that identified 124 patients amenable to further resection was 12,338 pounds per operated recurrence. Assuming that patients with recurrence gained 5 years' survival, the mean survival gain was 4.28 years per resection and the cost per life-year gained was 2883 pounds.
  
  
  CONCLUSIONS
  Intensive 3-monthly CT surveillance after liver resection for CRLM detects recurrence that is amenable to further resection in a considerable number of patients. These patients have significantly better survival with a reasonable cost per life-year gained.
authors.affiliation: Hepatobiliary and Transplantation Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: D
authors.initials: D
authors.lastname: Gomez
authors.forename: V K
authors.initials: VK
authors.lastname: Sangha
authors.forename: G
authors.initials: G
authors.lastname: Morris-Stiff
authors.forename: H Z
authors.initials: HZ
authors.lastname: Malik
authors.forename: A J
authors.initials: AJ
authors.lastname: Guthrie
authors.forename: G J
authors.initials: GJ
authors.lastname: Toogood
authors.forename: J P A
authors.initials: JP
authors.lastname: Lodge
authors.forename: K R
authors.initials: KR
authors.lastname: Prasad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms; D003362:Cost-Benefit Analysis; D005260:Female; D006498:Hepatectomy / Q000191:economics / Q000379:methods / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000191:economics; D016896:Treatment Outcome; D055815:Young Adult