Two dogs with juvenile-onset skin diseases with involvement of extremities.
Two dogs of juvenile-onset skin diseases with involvement of extremities were examined by histopathological, immunohistochemical and ultrastructural analyses. Clinically, both cases showed alopecia and crusts on the face and extremities. Case 1 showed histopathology of dermo-epidermal separation. Ultrastructural analysis revealed that the clefts were recognized between hemidesmosomes and lamina densa. In case 2, histopathology showed follicular atrophy, vacuolar degeneration at lower epidermis and masseter muscle degeneration, without remarkable ultrastructural abnormalities in basement membrane zone of the skin. Thus, the findings in case 1 were compatible to those in junctional epidermolysis bullosa, while those in case 2 were compatible to dermatomyositis-like disease. Combination of histopathological and ultrastructural analyses was useful to distinguish the diseases in two dogs.
Yoon
Ji-Seon
JS
Laboratory of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Minami
Tomohiko
T
Takizawa
Yasuko
Y
Sekiguchi
Maiko
M
Yabuzoe
Atsushi
A
Ide
Kaori
K
Nishifuji
Koji
K
Iwasaki
Toshiroh
T
D017668:Age of Onset; D000505:Alopecia / Q000473:pathology / Q000662:veterinary; D000818:Animals; D017931:DNA Primers; D020405:Dermis / Q000473:pathology / Q000648:ultrastructure; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004817:Epidermis / Q000473:pathology / Q000648:ultrastructure; D016109:Epidermolysis Bullosa, Junctional / Q000473:pathology / Q000662:veterinary; D007797:Laminin / Q000235:genetics; D008406:Masseter Muscle / Q000473:pathology / Q000648:ultrastructure; D016133:Polymerase Chain Reaction; D012871:Skin Diseases / Q000473:pathology / Q000662:veterinary*
D017931:DNA Primers; D007797:Laminin