title: [Update about advanced prostate cancer: diagnosis, treatment and ongoing perspectives].
abstract: Incidence of prostate cancer is constantly growing no matter of the stage of the disease. Locally advanced tumours and metastatic stages of the disease are not exception. Nevertheless, management of advanced prostate cancer is still uncertain. Thus, non invasive molecular or imaging techniques have been proposed to optimize the diagnosis of advanced prostate cancer. The debate is still ongoing regarding therapeutic options to offer to the patient to obtain the optimal oncologic control. Radical prostatectomy can now be considered as an option in certain cases of high-risk prostate cancer, on the basis of a multimodal treatment. The field of hormonotherapy is also evolving. New molecules (GnRH Antagonists, anti androgen) or new modalities of prescription (six-month GnRH agonist) appear. The prescription modalities evolve as well (e.g.; intermittent treatment). Lastly, chemotherapy is now proposed for metastatic symptomatic prostate cancer but also for locally advanced disease. Basic research and genetic investigations are still ongoing to explore pathways and factors of progression to the metastatic status and to find the most appropriate treatment for each patient.
authors.affiliation: Service d'Urologie Hôpital Pitié-Salpêtrière, Faculté de médecine Pierre et Marie Curie, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalo-Universitaire Est, Université Paris VI, Paris, France.
authors.forename: S J
authors.initials: SJ
authors.lastname: Drouin
authors.forename: M
authors.initials: M
authors.lastname: Rouprêt
mesh_terms: D018450:Disease Progression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*