[Albuminuria during the screening for diabetes in a semi-rural area (Kisantu City, DR Congo)].
OBJECTIVE
To determine the prevalence of microalbuminuria, macroalbuminuria and renal insufficiency at the time of screening for diabetes and impaired fasting glucose in the semi-rural area of Kisantu/DR Congo, and to identify determinants of pathological urinary albumin excretion (UAE).


METHODS
Step 1: diabetes (81 cases) and impaired fasting glucose (148 cases) tracking in the population (1898 subjects selected by a systematic survey). Step 2: urinary albumin and serum creatinine were measured and glomerular filtration rate was estimated (modification of the diet in renal disease [MDRD] equation). The determinants of pathological UAE were assessed by logistic regression.


RESULTS
The prevalence of macroalbuminuria and microalbuminuria in diabetes was 12.0 and 45.2% respectively versus 0 and 13.7% in impaired fasting glucose. Determinants of pathological UAE were: diabetes (adjusted OR [aOR]: 7.01; 95% CI: 3.48-14.11), central obesity (aOR: 2.36 [1.16-4.80]), age less that 60 years (aOR: 2.12 [1.05-4.40]), hypertension [aOR: 3.30 (1.39-7.82)] and diabetic retinopathy (aOR: 3.12 [1.54-6.26]). Renal insufficiency (MDRD<60ml/min/1.73m(2)) prevalence was 21.4% in diabetes and 3.8% in impaired fasting glucose.


CONCLUSIONS
Microalbuminuria and macroalbuminuria are frequently detected during screening for diabetes and impaired fasting glucose in a semi-rural area in DR Congo. They are especially associated with age above 60 years, central obesity and hypertension. Early and integrated management of diabetes is essential to prevent renal failure in the population.
Makulo
Rissassi
R
Service de néphrologie, cliniques universitaires de Kinshasa, Kinshasa, République démocratique du Congo. jrmakulo@yahoo.fr
Nseka
Mangani Nazaire
MN
Jadoul
Michel
M
Mvitu
Moise
M
Muyer
Muel Telo
MT
Kimenyembo
Wivine
W
Mandja
Makasa
M
Bieleli
Ebanz'Osongo
E
Mapatano
Mala Ali
MA
Epira
François Bompeka
FB
Sumaili
Ernest Kiswaya
EK
Kaimbo
W K
WK
Nge
Okwe
O
Buntinx
Frank
F
Muls
Erik
E
D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology*; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D012424:Rural Population