title: Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue.
abstract: Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or "click" synthetic methodology.
authors.affiliation: School of Biomedical, Biomolecular and Chemical Science, University of Western Australia, 35 Stirling Hwy, Crawley, 6009, WA, Australia. sgs@cyllene.uwa.edu.au
authors.forename: Scott G
authors.initials: SG
authors.lastname: Stewart
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Braun
authors.forename: Marta E
authors.initials: ME
authors.lastname: Polomska
authors.forename: Mahdad
authors.initials: M
authors.lastname: Karimi
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Abraham
authors.forename: Keith A
authors.initials: KA
authors.lastname: Stubbs
mesh_terms: D001710:Biotin / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry; D013237:Stereoisomerism; D013792:Thalidomide / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011092:Polyethylene Glycols; D013792:Thalidomide; D001710:Biotin