Mineral trioxide aggregate-based sealer: analysis of tissue reactions to a new endodontic material.
BACKGROUND
The aim of this study was to evaluate the subcutaneous connective tissue reaction to mineral trioxide aggregate (MTA)-based sealer (Endo CPM Sealer; CPM Sealer; EGEO SRL, Buenos Aires, Argentina), MTA, and an epoxy resin-based sealer (AH Plus; Dentsply HERO Indústria e Comércio Ltda, Petrópolis, RJ, Brazil).


METHODS
Polyethylene tubes containing the test materials and empty tubes (control group) were implanted in the subcutaneous tissue of 18 rats. After 7, 30, and 60 days, observations were made for cellular inflammatory components, fibrous condensation, and abscess formation. Comparisons between groups and periods of time were made using the Friedman test and the Kruskall-Wallis test.


RESULTS
Lymphocytes and plasmacytes were more intensely observed in the reaction to AH Plus sealer after 30 days (p < 0.05). MTA and the Endo CPM Sealer presented a behavior similar to that of the control group throughout the whole experiment.


CONCLUSIONS
The Endo CPM Sealer presented biological potential. Characteristics of the inflammatory reaction were equivalent to those produced by MTA.
Scarparo
Roberta Kochenborger
RK
School of Dentistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. robks@terra.com.br
Haddad
Daniel
D
Acasigua
Gerson Arison Xavier
GA
Fossati
Anna Cristina Medeiros
AC
Fachin
Elaine Vianna Freitas
EV
Grecca
Fabiana Soares
FS
D000038:Abscess / Q000145:classification; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D017610:Calcium Compounds / Q000494:pharmacology*; D003094:Collagen / Q000648:ultrastructure; D003238:Connective Tissue / Q000187:drug effects; D004338:Drug Combinations; D004853:Epoxy Resins / Q000494:pharmacology; D005355:Fibrosis; D015726:Giant Cells / Q000473:pathology; D007249:Inflammation; D008214:Lymphocytes / Q000473:pathology; D008422:Materials Testing; D010087:Oxides / Q000494:pharmacology*; D010950:Plasma Cells / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*; D040521:Subcutaneous Tissue / Q000187:drug effects; D013997:Time Factors
D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D004338:Drug Combinations; C540763:Endo-CPM-Sealer; D004853:Epoxy Resins; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C534916:epoxy resin-based root canal sealer; C086631:mineral trioxide aggregate; D003094:Collagen