title: 4,4'-Methylenedianiline-induced hepatitis in an industrial worker: case report and review of the literature.
abstract: 4,4'-Methylenedianiline (MDA) is a chemical used in manufacturing and insulation processes and is a well-known hepatotoxin. We report the case of a 42-year-old construction-site worker who was accidentally exposed to large amounts of MDA and developed acute liver damage. The clinical course is described, with particular emphasis on the timely identification of the underlying cause and prompt management that led to an uneventful recovery. We review the relevant literature and discuss the safety measures necessary to minimize similar occupational hazards in industrial workers.
authors.affiliation: First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece. olgagi@med.auth.gr
authors.forename: Olga
authors.initials: O
authors.lastname: Giouleme
authors.forename: Sofia
authors.initials: S
authors.lastname: Karabatsou
authors.forename: Prodromos
authors.initials: P
authors.lastname: Hytiroglou
authors.forename: Andreas
authors.initials: A
authors.lastname: Xanthis
authors.forename: Eleni
authors.initials: E
authors.lastname: Tsiaousi
authors.forename: Marios
authors.initials: M
authors.lastname: Katsaros
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Koliouskas
mesh_terms: D000208:Acute Disease; D000328:Adult; D000485:Allergens / Q000633:toxicity*; D000814:Aniline Compounds / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009784:Occupational Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome; D001559:Benzhydryl Compounds
chemical_list: D000485:Allergens; D000814:Aniline Compounds; D008775:Methylprednisolone; C009505:4,4'-diaminodiphenylmethane; D001559:Benzhydryl Compounds