title: Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients.
abstract: OBJECTIVE
  To determine whether or not the use of an arginine-containing nutritional supplement could result in significantly shorter pressure ulcer (PU) healing times in people with spinal cord injuries living in the community, compared with a comparative historical control group.
  
  
  METHODS
  Eighteen spinal-cord-injured patients (all part of a hospital spinal outreach service) received 9 g of a commercial powdered arginine supplement per day until full PU healing occurred. Healing rates were compared against 17 historical control patients (as assessed by medical history audit).
  
  
  RESULTS
  Baseline characteristics (age, gender, injury level and time) were similar between groups. Mean ulcer healing times were 10.5 +/- 1.3 weeks versus 21 +/- 3.7 weeks (p<0.05) in the intervention and control groups respectively. Comparison of healing rates in the intervention group against expected healing rates derived from the medical literature showed that intervention patients had a significantly shorter mean healing time (category 2 PU: 5.5+/-1.3 weeks versus 13.4 weeks; category 3 PU: 12.5 +/- 1.9 weeks versus 18.2 weeks; category 4 PU: 14.4 +/- 4.8 weeks versus 22.1 weeks). A diagnosis of diabetes did not significantly alter healing rates in either group.
  
  
  CONCLUSIONS
  Results from this observational study show a promising benefit of arginine supplementation on PU healing for individuals with spinal cord injury living in the community.
authors.affiliation: School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Brewer
authors.forename: K
authors.initials: K
authors.lastname: Desneves
authors.forename: L
authors.initials: L
authors.lastname: Pearce
authors.forename: K
authors.initials: K
authors.lastname: Mills
authors.forename: L
authors.initials: L
authors.lastname: Dunn
authors.forename: D
authors.initials: D
authors.lastname: Brown
authors.forename: T
authors.initials: T
authors.lastname: Crowe
mesh_terms: D000284:Administration, Oral; D001120:Arginine / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D003668:Pressure Ulcer / Q000175:diagnosis / Q000178:diet therapy* / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013119:Spinal Cord Injuries / Q000150:complications*; D013997:Time Factors; D016896:Treatment Outcome; D014739:Victoria; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001120:Arginine