Chemical constituents and antimicrobial activities of Canthium horridum.
Bioassay-guided isolation studies of the extract of Canthium horridum Bl. stem led to the isolation of ten compounds: (+)-syringaresinol (1), scoparone (2), scopoletin (3), 3'-methoxy-4'-hydroxy-trans-cinnamaldehyde (4), sinapic aldehyde (5), syringic acid (6), mannitol (7), vanillic acid 4-O-beta-D-glucopyranoside (8), beta-daucosterol (9), and beta-sitosterol (10). Compounds 1-10 were reported for the first time from this species, and compounds 1, 4, 5, 6, and 8 from the genus. The antimicrobial activities of the isolated compounds were studied; 6 had the highest activity against Bacillus subtilis, but 1 showed good activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Compounds 2, 4 and 6 also inhibited the growth of these three bacteria. None of the compounds demonstrated inhibitory activity against Aspergillus niger.
Yang
Biao
B
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, PR China.
Chen
Guangying
G
Song
Xiaoping
X
Chen
Zhong
Z
Song
Xinming
X
Wang
Jing
J
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D019666:Rubiaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents