Antimicrobial activity of DW286 against Streptococcus pneumoniae.
DW286 is a novel broad-spectrum fluoroquinolone with excellent antipneumococcal activity. The in vitro activity of DW286 was evaluated against quinolone-susceptible and -resistant Streptococcus pneumoniae and was compared with the activities of reference compounds. Among the tested agents, DW286 showed the most potent antibacterial activity against 94 quinolone-susceptible strains [minimum inhibitory concentration (MIC) 0.008-0.03 mg/L]. Against 23 quinolone-resistant S. pneumoniae with known resistance mechanisms, DW286 also had the lowest MICs of all the tested quinolones [MIC at which 90% of isolates were inhibited (MIC(90))=0.5mg/L], followed by ciprofloxacin, sparfloxacin, moxifloxacin and gemifloxacin. The in vivo activity of DW286 against penicillin-susceptible and -resistant S. pneumoniae was more effective than that of gemifloxacin.
Park
Hee Soo
HS
School of Life Sciences, Handong Global University, Puk-ku, Pohang City, Kyungbuk 791-708, South Korea.
Jung
Sung Ji
SJ
Choi
Dong-Rack
DR
Kwak
Jin-Hwan
JH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D004195:Disease Models, Animal; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000188:drug therapy*; D018805:Sepsis / Q000188:drug therapy; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D016019:Survival Analysis
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones