Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.
OBJECTIVE
To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population.


METHODS
We enrolled 200 patients with AF (mean age: 67 +/- 13 years) and 158 controls (mean age: 63 +/- 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods.


RESULTS
The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01).


CONCLUSIONS
In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF.
Lee
Kun-Tai
KT
Department of Internal Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC. kuntai.lee@msa.hinet.net
Yeh
Hi-Yin
HY
Tung
Chung-Po
CP
Chu
Chih-Sheng
CS
Cheng
Kai-Hung
KH
Tsai
Wei-Chung
WC
Lu
Ye-Hsu
YH
Chang
Jan-Gowth
JG
Sheu
Sheng-Hsiung
SH
Lai
Wen-Ter
WT
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
D017931:DNA Primers