title: Highly efficient production of [(18)F]fallypride using small amounts of base concentration.
abstract: To minimize the base concentration of a phase-transfer catalyst, [(18)F]fluoride was extracted from (18)O-enriched water trapped on an activated ion exchange cartridge (Chromafix PS-HCO(3)) using different concentrations of tetrabutylammonium bicarbonate (TBAHCO(3)) or Kryptofix 2.2.2./K(2)CO(3) in organic solvents such as CH(3)CN/H(2)O or MeOH/H(2)O. The optimal labeling condition for [(18)F]fallypride with automated synthesis was that 2 mg of tosyl-fallypride in acetonitrile (1 mL) was heated at 100 degrees C for 10 min using 40% TBAHCO(3) (10 microL). [(18)F]Fallypride was obtained with a high radiochemical yield of approximately 68+/-1.6% (decay-corrected, n=42) with a total synthesis time of 51+/-1.2 min, including HPLC purification and solid-phase purification for the final formulation.
authors.affiliation: Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 463-707, Republic of Korea.
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Moon
authors.forename: Jun Hyung
authors.initials: JH
authors.lastname: Park
authors.forename: Hong Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Hee Sup
authors.initials: HS
authors.lastname: Kil
authors.forename: Byoung Se
authors.initials: BS
authors.lastname: Lee
authors.forename: Dae Yoon
authors.initials: DY
authors.lastname: Chi
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Lee
authors.forename: Yu Kyeong
authors.initials: YK
authors.lastname: Kim
authors.forename: Sang Eun
authors.initials: SE
authors.lastname: Kim
mesh_terms: D002384:Catalysis; D005459:Fluorides / Q000737:chemistry*
chemical_list: D005459:Fluorides