Improved arene fluorination methodology for I(III) salts.
The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to "scale down" to the conditions used typically for radiotracer synthesis.
Wang
Bijia
B
Department of Chemistry and Nebraska Center for Materials and Nanoscience, University of Nebraska, Lincoln, Nebraska 68588-0304, USA.
Qin
Linlin
L
Neumann
Kiel D
KD
Uppaluri
ShriHarsha
S
Cerny
Ronald L
RL
DiMagno
Stephen G
SG
D001555:Benzene Derivatives / Q000737:chemistry*; D054879:Halogenation; D007202:Indicators and Reagents / Q000737:chemistry; D015394:Molecular Structure; D012492:Salts / Q000737:chemistry*
D001555:Benzene Derivatives; D007202:Indicators and Reagents; D012492:Salts