[Activated leukemic oncogenes responsible for neoplastic transformation of hematopoietic cells].
Leukemia is a heterogeneous group of malignant blood diseases, it could be characterized by the expansion of immature blast cells. It's still stay unknown the point molecular mechanism of leukemogenesis. It has been previously found that leukemia patients frequently have the mutations in genes responsible for normal proliferation and differentiation of hematopoietic stem cells. At present, scientific groups worldwide engaged in biomedical studies of structural and functional aspects of leukemic oncogenes and their role in human and beast leukemogenesis. In this review we describe the most recent conceptions of molecular properties of oncogenes activation of which may lead to the development of CBF-AML, in case of mutation in core-binding factors AML1 (CBFalpha) or CBFbeta.
Baskaran
D
D
Spirin
P V
PV
Prasolov
V S
VS
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*
D050676:Core Binding Factor Alpha 2 Subunit; D015513:Oncogene Proteins; C493728:RUNX1 protein, human