title: Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study.
abstract: OBJECTIVE
  To examine whether sleep duration was associated with incident-impaired fasting glucose (IFG) over 6 years of follow-up in the Western New York Health Study.
  
  
  METHODS
  Participants (N = 1,455, 68% response rate) who were free of type 2 diabetes and known cardiovascular disease at baseline (1996-2001) were reexamined in the period 2003-2004. A nested case-control study was conducted. Cases had fasting plasma glucose (FPG) less than 100 mg/dL at baseline and 100 to 125 mg/dL at follow-up: controls (n = 272) had FPG less than 100 mg/dL at both exams. Cases (n = 91) were individually matched to three controls (n = 272) on sex, race, and year of study enrollment. Average sleep duration was categorized as short (<6 hours), mid-range (6 to 8 hours), and long (>8 hours).
  
  
  RESULTS
  In multivariate conditional logistic regression after adjustment for several diabetes risk factors, the odds ratio (OR) of IFG among short sleepers was 3.0 (95% confidence limit [CL]: 1.05, 8.59) compared to mid-range sleepers. There was no association between long sleep and IFG: OR 1.6 (95% CL: 0.45, 5.42). Adjustment for insulin resistance attenuated the association only among short sleepers: OR 2.5 (95% CL: 0.83, 7.46).
  
  
  CONCLUSIONS
  Short sleep duration was associated with an elevated risk of IFG. Insulin resistance appears to mediate this association.
authors.affiliation: Department of Family Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, USA. rafalson@buffalo.edu
authors.forename: Lisa
authors.initials: L
authors.lastname: Rafalson
authors.forename: Richard P
authors.initials: RP
authors.lastname: Donahue
authors.forename: Saverio
authors.initials: S
authors.lastname: Stranges
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lamonte
authors.forename: Jacek
authors.initials: J
authors.lastname: Dmochowski
authors.forename: Joan
authors.initials: J
authors.lastname: Dorn
authors.forename: Maurizio
authors.initials: M
authors.lastname: Trevisan
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D005215:Fasting / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D012307:Risk Factors; D012892:Sleep Deprivation / Q000097:blood* / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose