Peptide-peptoid hybrids based on (1-11)-parathyroid hormone analogs.
A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor.
Caporale
A
A
Department of Chemical Sciences, Institute of Biomolecular Chemistry, CNR, University of Padova, Padova, Italy. caporaleandrea74@gmail.com
Schievano
E
E
Peggion
E
E
D057809:HEK293 Cells; D006801:Humans; D010281:Parathyroid Hormone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology; D034444:Peptoids / Q000737:chemistry* / Q000494:pharmacology; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000187:drug effects
D010281:Parathyroid Hormone; D010446:Peptide Fragments; D034444:Peptoids; D044168:Receptor, Parathyroid Hormone, Type 1; C454802:parathyroid hormone (1-11)