title: Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.
abstract: An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.
authors.affiliation: Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University. ohno@bio.keio.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohno
authors.forename: Taeko
authors.initials: T
authors.lastname: Watabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masaru
authors.initials: M
authors.lastname: Kawagoshi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Uotsu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Chiba
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamada
authors.forename: Kohji
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamada
authors.forename: Kenji
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uemura
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D047188:Chalcones; D005419:Flavonoids; D008543:Melanins; D010636:Phenols; D010936:Plant Extracts; C459212:bavachin; C468754:isobavachalcone; C012765:bakuchiol