Dual inhibition of wound healing and oxidative process by montelukast in experimental colon anastomoses.
BACKGROUND
The authors aimed to investigate the effects of montelukast (ML) on the experimental rat colon anastomosis.


METHODS
A total of 80 Wistar albino rats were divided into 4 groups: sham-operated, colon anastomosis, and colon anastomosis with oral administration (OAML) and rectal administration of 10 mg/kg/d ML (RAML). Anastomotic bursting pressure, anastomotic hydroxyproline contents, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPX), and superoxide dismutase (SOD) levels, and the expressions of Ki-67, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) with immunohistochemistry were assessed on postoperative day 5.


RESULTS
Anastomotic bursting pressures and bFGF expressions were not changed, whereas tissue hydroxyproline concentrations and MDA levels and the expressions of Ki-67 and VEGF were significantly decreased, and GSH, GPX, and SOD levels were significantly increased in the OAML and RAML groups.


CONCLUSIONS
ML causes impairment of wound healing without altering the anastomosis bursting pressure and reverses the oxidative damage of the colon anastomoses in rats.
Canbay
Emel
E
General Surgery, Basaksehir State Hospital, Basaksehir, Istanbul, Turkey. dremelcanbay@gmail.com
Agachan
Bedia
B
Ozturk
Tulin
T
Giris
Murat
M
Asoglu
Oktar
O
Balik
Emre
E
Bugra
Dursun
D
D000085:Acetates / Q000008:administration & dosage*; D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000601:surgery*; D003521:Cyclopropanes; D004195:Disease Models, Animal; D020024:Leukotriene Antagonists / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects*; D011804:Quinolines / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast