Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia.
OBJECTIVE
To demonstrate the possible associations between genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and esophageal squamous cell dysplasia (ESCD).


METHODS
All participants came from an area of high incidence of esophageal cancer and underwent an endoscopic staining examination; biopsies were taken from a non-staining area of the mucosa and diagnosed by histopathology. Based on the examinations, the subjects were divided into the control group with normal esophageal squamous epithelial cells and the ESCD group. ALDH2 genotypes of 396 cases were determined including 184 ESCD cases and 212 controls. The odds ratio (OR) and 95% confidence intervals (95% CI) were calculated by binary logistic regression models.


RESULTS
The distribution of ALDH2 genotypes showed significant differences between the two groups. The adjustment factors were gender and age in the logistic regression models. Compared with 2*2/2*2 genotype, 2*1/2*1 genotype was found to be a risk factor for ESCD, and the OR (95% CI) was 4.50 (2.21-9.19). There were significant correlations between ALDH2 genotypes and alcohol drinking/smoking/history of esophageal cancer.


CONCLUSIONS
The ALDH2 polymorphism is significantly associated with ESCD.
Zhou
Ying-Zhi
YZ
School of Economics, Shandong University, 27# Shanda Nanlu, Jinan 250100, Shandong Province, China.
Diao
Yu-Tao
YT
Li
Hao
H
Li
Hui-Qing
HQ
Ma
Qing
Q
Cui
Jia
J
D000328:Adult; D000368:Aged; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D004476:Ectodermal Dysplasia / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016017:Odds Ratio; D011110:Polymorphism, Genetic
C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial