title: Clinical utility of genotypic resistance tests for HIV-1-infected patients with low-level virological failure.
abstract: The usefulness of genotypic resistance tests (GRT) among HIV-1 patients with low-level virological failure (LLVF) was evaluated. Up to 78% of samples with <1,000 copies/ml were sequenced successfully. For samples with 50 to 200 copies/ml, the success rate was as high as 69%. LLVF should not deter clinicians from requesting GRT.
authors.affiliation: Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Elgalib
authors.forename: M
authors.initials: M
authors.lastname: Perry
authors.forename: M
authors.initials: M
authors.lastname: Aboud
authors.forename: J
authors.initials: J
authors.lastname: Mullen
authors.forename: S
authors.initials: S
authors.lastname: O'Shea
authors.forename: I L
authors.initials: IL
authors.lastname: Chrystie
authors.forename: R
authors.initials: R
authors.lastname: Kulasegaram
authors.forename: C Y W
authors.initials: CY
authors.lastname: Tong
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D020125:Mutation, Missense; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral