title: A microneedle roller for transdermal drug delivery.
abstract: Microneedle rollers have been used to treat large areas of skin for cosmetic purposes and to increase skin permeability for drug delivery. In this study, we introduce a polymer microneedle roller fabricated by inclined rotational UV lithography, replicated by micromolding hydrophobic polylactic acid and hydrophilic carboxy-methyl-cellulose. These microneedles created micron-scale holes in human and porcine cadaver skin that permitted entry of acetylsalicylic acid, Trypan blue and nanoparticles measuring 50nm and 200nm in diameter. The amount of acetylsalicylic acid delivered increased with the number of holes made in the skin and was 1-2 orders of magnitude greater than in untreated skin. Lateral diffusion in the skin between holes made by microneedles followed expected diffusional kinetics, with effective diffusivity values that were 23-160 times smaller than in water. Compared to inserting microneedles on a flat patch, the sequential insertion of microneedles row by row on a roller required less insertion force in full-thickness porcine skin. Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery.
authors.affiliation: Department of BioNano Technology and Gachon BioNano Research Institute, Kyungwon University, Seongnam, Republic of Korea. pa90201@kyungwon.ac.kr
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Park
authors.forename: Seong-O
authors.initials: SO
authors.lastname: Choi
authors.forename: Soonmin
authors.initials: S
authors.lastname: Seo
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Choy
authors.forename: Mark R
authors.initials: MR
authors.lastname: Prausnitz
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008845:Microinjections; D053758:Nanoparticles; D009339:Needles; D010316:Particle Size; D010539:Permeability; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D012869:Skin Absorption; D013552:Swine; D014343:Trypan Blue / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D014343:Trypan Blue; D002266:Carboxymethylcellulose Sodium; D001241:Aspirin