title: Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis.
abstract: To test the hypothesis that bacterial contamination of menstrual blood could be a local biologic event in the development of endometriosis, menstrual blood was cultured and bacterial endotoxin was measured in menstrual blood and peritoneal fluid. Our results suggest that compared with control women, higher colony formation of Escherichia coli in menstrual blood and endotoxin levels in menstrual fluid and peritoneal fluid in women with endometriosis may promote Toll-like receptor 4-mediated growth of endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. nemokhan@nagasaki-u.ac.jp
authors.forename: Khaleque Newaz
authors.initials: KN
authors.lastname: Khan
authors.forename: Michio
authors.initials: M
authors.lastname: Kitajima
authors.forename: Koichi
authors.initials: K
authors.lastname: Hiraki
authors.forename: Naohiro
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Katamine
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakashima
authors.forename: Akira
authors.initials: A
authors.lastname: Fujishita
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Ishimaru
authors.forename: Hideaki
authors.initials: H
authors.lastname: Masuzaki
mesh_terms: D000293:Adolescent; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry / Q000382:microbiology / Q000473:pathology; D001769:Blood / Q000382:microbiology; D016022:Case-Control Studies; D002478:Cells, Cultured; D015169:Colony Count, Microbial; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D004715:Endometriosis / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004731:Endotoxins / Q000097:blood / Q000633:toxicity*; D004927:Escherichia coli Infections / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008598:Menstruation / Q000097:blood*; D010532:Peritoneal Diseases / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D055815:Young Adult
chemical_list: D016207:Cytokines; D004731:Endotoxins; C044101:endotoxin, Escherichia coli