title: Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression.
abstract: OBJECTIVE
  The line bisection error to the left of the true center has been interpreted as a relative right hemisphere activation, which might relate to the subject's emotional state. Considering that patients with generalized anxiety disorder (GAD) or treatment-resistant depression (TRD) often have negative emotions, we hypothesized that these patients would bisect lines significantly leftward.
  
  
  METHODS
  We tried the line bisection task in the right-handed healthy volunteers (n = 56), GAD (n = 47) and TRD outpatients (n = 52). Subjects also completed the Zuckerman - Kuhlman Personality Questionnaire, the Zuckerman Sensation Seeking Scales, and the Plutchik-van Praag Depression Inventory.
  
  
  RESULTS
  GAD patients scored highest on the Neuroticism-Anxiety trait, TRD patients scored highest on depression, and both patients scored lower on the Sociability trait. Patients with GAD also bisected lines significantly leftward compared to the healthy subjects. The Frequency of the bisection error was negatively correlated with Disinhibition-Seeking in the healthy subjects, and with Total sensation-seeking and Experience-Seeking in GAD patients, while the Magnitude of the line bisection error was negatively correlated with depression in TRD patients.
  
  
  CONCLUSIONS
  The study suggests a stronger right hemispheric activation, a weaker left activation, or both in the GAD, instead of TRD patients.
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. wangmufan@msn.com
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Chai
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shaohua
authors.initials: S
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001008:Anxiety Disorders / Q000503:physiopathology* / Q000523:psychology; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult