Magnesium(II)-binaphtholate as a practical chiral catalyst for the enantioselective direct Mannich-type reaction with malonates.
A highly enantioselective direct Mannich-type reaction of aldimines with dialkyl malonates was developed with the use of a Mg(II)-BINOLate salt, which was designed as a cooperative acid-base catalyst that can activate both aldimines and malonates. Optically active beta-aminoesters and alpha-halo-beta-aminoesters could be synthesized in high yields and with high enantioselectivities. This inexpensive and practical Mg(II)-BINOLate salt could be used in gram-scale catalysis.
Hatano
Manabu
M
Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan.
Horibe
Takahiro
T
Ishihara
Kazuaki
K