title: Preoperative acidosis and infant development following surgery for congenital heart disease.
abstract: OBJECTIVE
  Prenatal diagnosis has been shown to decrease pre-operative acidosis and might prevent the occurrence of disturbed developmental outcome. The aim of this study is to evaluate parameters for acidosis and their predictive value on developmental outcome in newborns with congenital heart disease.
  
  
  METHODS
  A total of 117 patients requiring surgery for structural heart disease in the first 31 days of life were included. Diagnosis was established either pre- or postnatally. Preoperative values of lactate, pH and base excess levels were compared to the occurrence of disturbed developmental outcome, i.e. an underperformance of more than 10% on the P90 of a standardized Dutch developmental scale. Patients were divided into groups according to blood levels of acidosis parameters, using receiver operating characteristics curves to determine cut-off values for pH, base excess and lactate.
  
  
  RESULTS
  No significant difference in developmental outcome was found using values for pH or base excess as a cut-off level. Preoperative lactate values exceeding 6.1 mmol/l resulted in a significant increase in impaired development compared to infants with a pre-operative lactate lower than 6.1 mmol/l: 40.9% vs 15.1% in (p=0.03).
  
  
  CONCLUSIONS
  Pre-operative lactate values might have a prognostic value on developmental outcome in newborns with congenital heart disease. The limited prognostic value of pH can be explained by the fact that pH can be easily corrected, while lactate better reflects the total oxygen debt experienced by these patients.
authors.affiliation: Department of Colorectal Surgery, Royal Brisbane and Women's Hospital, Herston, Australia.
authors.forename: P M
authors.initials: PM
authors.lastname: Verheijen
authors.forename: L A
authors.initials: LA
authors.lastname: Lisowski
authors.forename: S
authors.initials: S
authors.lastname: Wassink
authors.forename: G H A
authors.initials: GH
authors.lastname: Visser
authors.forename: E J
authors.initials: EJ
authors.lastname: Meijboom
mesh_terms: D000140:Acidosis, Lactic / Q000175:diagnosis* / Q000401:mortality; D002315:Cardiopulmonary Bypass; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000401:mortality; D006324:Heart Arrest, Induced; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D019344:Lactic Acid / Q000097:blood; D011296:Prenatal Diagnosis; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D019344:Lactic Acid