title: Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature.
abstract: Focal epithelial hyperplasia is increasingly frequently observed in rural South African communities. HIV-seropositive subjects have a higher prevalence of oral human papillomavirus (HPV) infections than immunocompetent subjects; and paradoxically, the introduction of highly active antiretroviral therapy for treatment of HIV-seropositive subjects is associated with increased frequency of focal epithelial hyperplasia. We describe a case of focal epithelial hyperplasia in an HIV-seropositive child receiving highly active antiretroviral therapy, who was successfully treated by using diode laser ablation.
authors.affiliation: Department of Periodontology and Oral Medicine, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa. lfeller@ul.ac.za
authors.forename: L
authors.initials: L
authors.lastname: Feller
authors.forename: R A G
authors.initials: RA
authors.lastname: Khammissa
authors.forename: N H
authors.initials: NH
authors.lastname: Wood
authors.forename: V
authors.initials: V
authors.lastname: Malema
authors.forename: R
authors.initials: R
authors.lastname: Meyerov
authors.forename: J
authors.initials: J
authors.lastname: Lemmer
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002648:Child; D005148:Facial Dermatoses / Q000821:virology; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000139:chemically induced* / Q000601:surgery; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D053685:Laser Therapy; D030361:Papillomavirus Infections / Q000175:diagnosis; D014860:Warts / Q000821:virology