[Changes in various immunological parameters of lacrimal fluid in excessive scarring after antiglaucoma surgery in patients with primary open-angle glaucoma].
Twenty-two patients in whom the expression of the human beta-defensin-2 (HBD-2) gene and the concentrations of human neutrophil peptides (HNP 1-3) and interleukin-17 (IL-17) were determined in the conjunctiva and lacrimal fluid were followed. In patients with primary open-angle glaucoma, the baseline concentrations of HNP 1-3 and IL-17 in lacrimal fluid and the expression of the HBD-2 gene in the conjunctival epithelial cells were higher than those in healthy individuals. The appearance of signs of pathological scarring was observed when HBD-2 expression in the conjunctival epithelial cells was lower and the rate of changes in the lacrimal fluid concentrations of HNP 1-3 and IL-17 was stable.
Erichev
V P
VP
Gankovskaia
L V
LV
Koval'chuk
L V
LV
Gankovskaia
O A
OA
Dugina
A E
AE
D000368:Aged; D000369:Aged, 80 and over; D002921:Cicatrix / Q000209:etiology / Q000276:immunology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000276:immunology* / Q000601:surgery; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology*; D013666:Tears / Q000276:immunology* / Q000378:metabolism; D023084:alpha-Defensins / Q000378:metabolism; D023083:beta-Defensins / Q000378:metabolism
D020381:Interleukin-17; D023084:alpha-Defensins; D023083:beta-Defensins