Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease.
BACKGROUND
Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis. This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD).


METHODS
The collateral scoring system developed by Rentrop was used to classify 393 patients according to their collaterals as either "poor" (grades 0 and 1) or "good" (grades 2 and 3). Gene polymorphisms were analyzed by TaqMan assay.


RESULTS
The frequency of +405C and -2578A alleles was higher in the good collaterals group (p=0.007 and 0.005, respectively). For the +405C>G allele, the odds ratio (OR) of good collaterals for CC to GG genotype was 2.54 (p=0.003). For the -2578A allele, the OR of good collaterals for AA to CC genotype was 2.31 (p=0.038). Univariate and logistic regression analysis found 2 polymorphisms in the additive model for associations with collateral development: +405C>G (p=0.005 and 0.010) and -2578C>A (p=0.006 and 0.006). The VEGF +405C>G polymorphism and DM revealed an interactive effect on collateral development (p=0.027).


CONCLUSIONS
The VEGF +405C>G and -2578C>A polymorphisms might be novel genetic factors affecting collateral development in Chinese patients.
Lin
Tsung-Hsien
TH
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan.
Wang
Chiao-Ling
CL
Su
Ho-Ming
HM
Hsu
Po-Chao
PC
Juo
Suh-Hang Hank
SH
Voon
Wen-Chol
WC
Shin
Shyi-Jang
SJ
Lai
Wen-Ter
WT
Sheu
Sheng-Hsiung
SH
D000368:Aged; D044466:Asian People / Q000235:genetics; D003097:Collateral Circulation / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A