title: Sustained protection from pentavalent rotavirus vaccination during the second year of life at a large, urban United States pediatric hospital.
abstract: Fecal specimens from children presenting to Texas Children's Hospital with acute gastroenteritis were tested for the presence of rotavirus. Children were grouped according to vaccination status, and pentavalent rotavirus vaccine effectiveness was calculated. Pentavalent rotavirus vaccine effectiveness against severe rotavirus gastroenteritis was sustained during the first 2 years of the vaccination program. Overall 3-dose effectiveness was 83% to 86%; it was 92% to 93% among children 6 to 11 months of age and 78% to 84% among children ≥12 months of age.
authors.affiliation: Center for Vaccine Awareness and Research, Texas Children's Hospital, Houston, TX 77030, USA. jboom@bcm.edu
authors.forename: Julie A
authors.initials: JA
authors.lastname: Boom
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.forename: Leila C
authors.initials: LC
authors.lastname: Sahni
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Rench
authors.forename: Osbourne
authors.initials: O
authors.lastname: Quaye
authors.forename: Slavica
authors.initials: S
authors.lastname: Mijatovic-Rustempasic
authors.forename: Manish M
authors.initials: MM
authors.lastname: Patel
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Baker
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
mesh_terms: D000367:Age Factors; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000276:immunology*; D013781:Texas; D014505:Urban Population; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated