title: Individually adapted, interactive multiplanar reformations vs. semi-automated coronary segmentation and curved planar reformations for stenosis detection in coronary computed tomography angiography.
abstract: OBJECTIVE
  To evaluate, whether semi-automated vessel extraction and curved planar reformations ("automated vessel extraction") increases diagnostic accuracy in the detection of relevant coronary artery lesions compared to manual, interactive multiplanar interpretation ("manual approach").
  
  
  METHODS
  50 coronary CT angiography datasets were evaluated by four independent readers (two experienced, two novice) for the presence of stenoses exceeding 50% diameter reduction. One experienced and one novice reader each used the "manual approach" for cases 1-25 and "automated vessel extraction" for cases 26-50, while the other two readers used the complementary method. Results were compared to those of invasive coronary angiography.
  
  
  RESULTS
  Using the "manual approach", 37 of 42 stenoses were correctly detected by experienced as well as novice readers. 14 vs. 17 lesions were false positive (sensitivity 88%, specificity 91% vs. 89%, PPV 73% vs. 69%, NPV 97%, n.s.). Using "automated vessel extraction", experienced readers detected 35/42 stenoses compared to 31/42 for novice readers. 7 vs. 11 lesions were missed and 17 vs. 15 false-positive lesions reported (sensitivity 83% vs. 74%, specificity 89% vs. 90%, PPV 67%, NPV 95% vs. 93%, n.s.).In patient-based analysis, for novice readers sensitivity was higher using the "manual approach" (97%, 29/30 pts. vs. 80%, 24/30 pts., p=0.069).
  
  
  CONCLUSIONS
  Semi-automated vessel extraction and curved multiplanar reconstructions do not improve the diagnostic accuracy of coronary CT angiography compared to the use of interactive multiplanar reformations. Especially for less experienced readers, the use of automatically rendered curved multiplanar reconstructions alone cannot be recommended.
authors.affiliation: University of Erlangen, Department of Radiology, Maximiliansplatz 1, 91054 Erlangen, Germany. katharina.anders@uk-erlangen.de
authors.forename: Katharina
authors.initials: K
authors.lastname: Anders
authors.forename: Ulrike
authors.initials: U
authors.lastname: Ropers
authors.forename: Axel
authors.initials: A
authors.lastname: Kuettner
authors.forename: Martin
authors.initials: M
authors.lastname: Wechsel
authors.forename: Werner G
authors.initials: WG
authors.lastname: Daniel
authors.forename: Michael
authors.initials: M
authors.lastname: Uder
authors.forename: Stephan
authors.initials: S
authors.lastname: Achenbach
mesh_terms: D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed