title: Model-based decision support in diabetes care.
abstract: The model-based Karlsburg Diabetes Management System (KADIS®) has been developed as a patient-focused decision-support tool to provide evidence-based advice for physicians in their daily efforts to optimize metabolic control in diabetes care of their patients on an individualized basis. For this purpose, KADIS® was established in terms of a personalized, interactive in silico simulation procedure, implemented into a problem-related diabetes health care network and evaluated under different conditions by conducting open-label mono- and polycentric trials, and a case-control study, and last but not least, by application in routine diabetes outpatient care. The trial outcomes clearly show that the recommendations provided to the physicians by KADIS® lead to significant improvement of metabolic control. This model-based decision-support system provides an excellent tool to effectively guide physicians in personalized decision-making to achieve optimal metabolic control for their patients.
authors.affiliation: Institute of Diabetes "Gerhardt Katsch" Karlsburg, Greifswalder Str. 11e, D-17495 Karlsburg, Germany. salzsied@diabetes-karlsburg.de
authors.forename: E
authors.initials: E
authors.lastname: Salzsieder
authors.forename: L
authors.initials: L
authors.lastname: Vogt
authors.forename: K-D
authors.initials: KD
authors.lastname: Kohnert
authors.forename: P
authors.initials: P
authors.lastname: Heinke
authors.forename: P
authors.initials: P
authors.lastname: Augstein
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002986:Clinical Trials as Topic; D003198:Computer Simulation; D003491:Cybernetics; D003661:Decision Support Techniques; D003920:Diabetes Mellitus / Q000097:blood / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000628:therapy; D006296:Health Services / Q000706:statistics & numerical data; D006801:Humans; D008954:Models, Biological
chemical_list: D001786:Blood Glucose