title: Conduction aphasia as an initial symptom in a patient with Creutzfeldt-Jakob disease.
abstract: We report a 59-year-old woman who presented to our facility with conduction aphasia as an initial symptom which, within 3months, was followed by generalized myoclonus and global aphasia. She had difficulty repeating words during the Korean-Western Aphasia Battery test. Diffusion-weighted MRI demonstrated ribbon-like hyperintensities in the bilateral temporal, parietal and occipital cerebral cortex. An electroencephalogram showed periodic discharges over the bilateral hemispheres, while single photo emission CT revealed diminished perfusion. After a positive finding of the 14-3-3 protein in her cerebrospinal fluid, she was diagnosed as having probable sporadic Creutzfeldt-Jakob disease.
authors.affiliation: Department of Neurology, Chung-Ang University College of Medicine, Heukseok-dong, Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Song
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Yang
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Seo
authors.forename: Sam-Yeol
authors.initials: SY
authors.lastname: Ha
authors.forename: Kwang-Yeol
authors.initials: KY
authors.lastname: Park
authors.forename: Oh-Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Youn
mesh_terms: D018886:Aphasia, Conduction / Q000209:etiology*; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods