DNA replication: metazoan Sld3 steps forward.
In yeast, phosphorylation of the Sld3 protein by cyclin-dependent kinases is essential for replication initiation. In metazoans, three potential Sld3 counterparts have emerged. A new study suggests that one of these, Treslin/Ticrr, is the Sld3 ortholog.
Fu
Yu V
YV
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA.
Walter
Johannes C
JC
D018797:Cell Cycle Proteins / Q000502:physiology*; D004261:DNA Replication; D004271:DNA, Fungal / Q000235:genetics; D004268:DNA-Binding Proteins / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*
D018797:Cell Cycle Proteins; D004271:DNA, Fungal; D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; C426020:Sld3 protein, S cerevisiae