Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation.
This study investigates the role of basolateral amygdala (BLA) dopamine in heroin-induced conditioned immunomodulation. Animals underwent conditioning in which heroin administration was repeatedly paired with placement into a conditioning chamber. Six days after the final conditioning session animals were returned to the chamber and received intra-BLA microinfusions of dopamine, D(1) or D(2), antagonist. Antagonism of D(1), but not D(2), receptors within the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS, TNF-α and IL-1β. This study is the first to demonstrate that the expression of heroin's conditioned effects on proinflammatory mediators require dopamine D(1) receptors within the BLA.
Szczytkowski
Jennifer L
JL
Department of Psychology, CB#3270, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3270, USA. jthomson@email.unc.edu
Lysle
Donald T
DT
D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004347:Drug Interactions; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects; D003932:Heroin / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008845:Microinjections / Q000379:methods; D009294:Narcotics / Q000494:pharmacology*; D009566:Nitrates / Q000097:blood; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001552:Benzazepines; D018492:Dopamine Antagonists; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D009294:Narcotics; D009566:Nitrates; D009573:Nitrites; D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D014409:Tumor Necrosis Factor-alpha; D003932:Heroin; D052247:Nitric Oxide Synthase Type II