title: Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
abstract: Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45).
authors.affiliation: Department of Ophthalmology and Visual Science, Yokohama City University, Yokohama, Kanagawa, Japan. mizunobu@med.yokohama-cu.ac.jp
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shiota
authors.forename: Tatsukata
authors.initials: T
authors.lastname: Kawagoe
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ito
authors.forename: Jiro
authors.initials: J
authors.lastname: Kera
authors.forename: Eiichi
authors.initials: E
authors.lastname: Okada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yatsu
authors.forename: Yeong-Wook
authors.initials: YW
authors.lastname: Song
authors.forename: Eun-Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Horie
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takeno
authors.forename: Sunao
authors.initials: S
authors.lastname: Sugita
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Seiamak
authors.initials: S
authors.lastname: Bahram
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
mesh_terms: D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005123:Eye; D055106:Genome-Wide Association Study; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D016017:Odds Ratio; D012871:Skin Diseases / Q000235:genetics; D014421:Turkey
chemical_list: D016753:Interleukin-10