Chemokine-chemokine receptors in cancer immunotherapy.
A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit the coordinated trafficking and organization of cells within these specific tissues. Since the chemokine network plays critical roles in both the function of the immune system and the progression of cancer, it is an attractive target for therapeutic manipulation. This review will focus on chemokine and chemokine receptor network-related therapeutic interventions that utilize host-tumor interactions particularly involving the immune system.
Stewart
Trina J
TJ
Cancer Immunology Research Program, The Peter MacCallum Cancer Centre, Level 2 Smorgon Family Building, St Andrews Place, East Melbourne, Victoria, 3002, Australia. trina.stewart@petermac.org
Smyth
Mark J
MJ
D056704:Adaptive Immunity; D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D018925:Chemokines; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D009928:Organ Specificity; D019707:Receptors, Chemokine; D019139:Tumor Escape
D018925:Chemokines; D019707:Receptors, Chemokine