Carbazole alkaloids from the stems of Clausena excavata.
A new carbazole alkaloid, sansoakamine (8), together with 11 known compounds, was isolated from the stems of Clausena excavata. All structures were elucidated by spectroscopic methods. Compound 7 showed moderate anti-malarial activity against Plasmodium falciparum with a MIC value of 6.74 microg/ml.
Sripisut
Tawanun
T
Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Chiang Rai, Thailand.
Laphookhieo
Surat
S
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D054700:Clausena / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013785:Thailand
D000470:Alkaloids; D000962:Antimalarials; D002227:Carbazoles; C551218:sansoakamine