title: Diagnosis and management of immunodeficiencies in adults by allergologists.
abstract: Primary immunodeficiencies (PIDs) are genetic diseases that cause alterations in the immune response and occur with an increased rate of infection, allergy, autoimmune disorders, and cancer. They affect adults and children, and the diagnostic delay, morbidity, effect on quality of life, and socioeconomic impact are important. Therapy (gamma-globulin substitution in most cases) is highly effective. We examine adult PIDs and their clinical presentation and provide a sequential and directed framework for their diagnosis. Finally, we present a brief review of the most important adult PIDs, common variable immunodeficiency, including diagnosis, pathogenesis, clinical signs, and disease management.
authors.affiliation: Department of Pediatric Allergology and Clinical Immunology, Hospital de Cruces, Baracaldo-Vizcaya, Spain. juanmiguel.garciamartinez@osakidetza.net
authors.forename: J M
authors.initials: JM
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: Gamboa
authors.forename: A
authors.initials: A
authors.lastname: de la Calle
authors.forename: M D
authors.initials: MD
authors.lastname: Hernández
authors.forename: M T
authors.initials: MT
authors.lastname: Caballero
authors.forename: B E
authors.initials: BE
authors.lastname: García
authors.forename: M
authors.initials: M
authors.lastname: Labrador
authors.forename: C
authors.initials: C
authors.lastname: Lahoz
authors.forename: N
authors.initials: N
authors.lastname: Longo Areso
authors.forename: M
authors.initials: M
authors.lastname: López Hoyos
authors.forename: J
authors.initials: J
authors.lastname: Martínez Quesada
authors.forename: L
authors.initials: L
authors.lastname: Mayorga
authors.forename: F J
authors.initials: FJ
authors.lastname: Monteseirin
authors.forename: M L
authors.initials: ML
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D007371:Interferon-gamma / Q000627:therapeutic use; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D005719:gamma-Globulins; D007371:Interferon-gamma