title: [Karyomegalic interstitial nephritis: A new French case].
abstract: Karyomegalic interstitial nephritis (KIN) is a rare and slowly progressive chronic interstitial nephritis (CIN) (28 cases reported), described for the first time by Mihatsch et al. in 1979. Here, we report on a 50-year-old woman who presented with asymptomatic renal failure and mild proteinuria without hematuria. Renal biopsy showed large tubulo-interstitial fibrosis and massively enlarged tubular epithelial cell nuclei, without viral inclusion. KIN is a rare CIN defined by a karyomegaly of tubular epithelial cell nuclei. Its pathogenesis remains obscure. Nevertheless, an exogenous factor is suspected, ochratoxin A particularly. The familial clustering of patients and the frequency of HLA-A9 and HLA-B35 haplotypes suggest the presence of a possible genetic susceptibility to this disorder.
authors.affiliation: hôpital Saint-Louis, AP-HP, Paris, France. jerome.verine@sls.aphp.fr
authors.forename: Jérôme
authors.initials: J
authors.lastname: Verine
authors.forename: Richard
authors.initials: R
authors.lastname: Reade
authors.forename: Anne
authors.initials: A
authors.lastname: Janin
authors.forename: Dominique
authors.initials: D
authors.lastname: Droz
mesh_terms: D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology*