title: The use of autologous platelet gel in toenail surgery: a within-patient clinical trial.
abstract: A number of studies have stressed the importance of platelets in acute and chronic wound healing, although their clinical utility remains controversial. To analyze the use of autologous platelet gel in the surgical treatment of ingrown toenails, a within-patient clinical trial was conducted. Thirty-five healthy volunteers (70 feet) underwent surgical treatment for bilateral ingrown hallux nails. Recovery time (days), postoperative pain (analog chromatic scale), and inflammation (digital circumference) at 48 hours postoperative were the outcomes of interest. Recovery time and postoperative pain were less in the experimental group, although the differences of means were not statistically significant. Based on these results, we suggest that local application of APG in surgical ingrown toenail wounds may produce a slight increase in acute inflammatory phase dermal wound healing, but it does not cause a statistically significant reduction in recovery times or postoperative pain.
authors.affiliation: School of Health Sciences, Department of Podiatry, Seville University, Seville, Spain. acordoba@us.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Córdoba-Fernández
authors.forename: Rafael
authors.initials: R
authors.lastname: Rayo-Rosado
authors.forename: José María
authors.initials: JM
authors.lastname: Juárez-Jiménez
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005782:Gels / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000187:drug effects / Q000601:surgery; D009263:Nails, Ingrown / Q000188:drug therapy* / Q000601:surgery; D010149:Postoperative Pain / Q000517:prevention & control; D053657:Platelet-Rich Plasma; D020127:Recovery of Function; D016037:Single-Blind Method; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D005782:Gels