Potential value of color-coded dynamic breast-specific gamma-imaging; comparing (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP in a mouse mammary tumor model.
Using a mouse mammary tumor model based on orthotopic transplantation of luciferase-expressing mouse ILC cells (KEP1-Luc cells), we evaluated the diagnostic value of three clinically applied tracers: (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP. Uptake of the tracers is compared using static and dynamic imaging procedures. We found that dynamic imaging in combination with pixel-by-pixel color coding has an added value over (high resolution) static imaging procedures. Such dynamic imaging procedures could enhance the potential of breast-specific gamma-imaging.
van Leeuwen
Fijs W B
FW
Department of Radiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands. fw.v.leeuwen@nki.nl
Buckle
Tessa
T
Batteau
Lukas
L
Pool
Bert
B
Sinaasappel
Michiel
M
Jonkers
Jos
J
Gilhuijs
Kenneth G A
KG
D000818:Animals; D003116:Color; D005260:Female; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging*; D008327:Mammography; D051379:Mice; D018613:Microscopy, Confocal; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals