Plasma visfatin is increased after high-intensity exercise.
OBJECTIVE
Visfatin is a newly characterized protein that is highly expressed in visceral adipose tissue and may play a role in insulin resistance. We investigated the effects of repeated short bouts of high-intensity exercise on plasma visfatin and related metabolic responses.


METHODS
Six young, physically fit men (22.8 +/- 2.3 years; 78.5 +/- 2.3 kg; and body mass index 22.1 +/- 1.2) performed a single session of a running-based anaerobic sprint exercise (7 sets of 6 x 35 m every 10 s, with 1 min rest between sets). Venous blood samples were collected before, immediately after, and 45 and 90 min after exercise to assess plasma visfatin, insulin, glucose, lactate and glutathione responses.


RESULTS
After adjustment for postexercise changes in plasma volume, the data indicate a significant increase in plasma visfatin (12.5 +/- 2.0 vs. 26.6 +/- 3.9 ng/ml, p < 0.02), insulin (p < 0.05), and glucose (p < 0.002) concentrations, and homeostasis model assessment of insulin resistance (p < 0.02), immediately after the exercise session. At 45 min of recovery, all metabolic measures, with the exception of lactate, had returned to baseline levels.


CONCLUSIONS
The elevation in plasma visfatin, together with increased plasma glucose and insulin concentrations immediately after high-intensity exercise, may sensitize tissues for postexercise glucose uptake and glycogen restoration. Our results also support a temporary and early postexercise anorexigenic metabolic state.
Ghanbari-Niaki
Abbass
A
University of Mazandaran, Babolsar, Iran.
Saghebjoo
Marziyeh
M
Soltani
Raheleh
R
Kirwan
John P
JP
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D015444:Exercise; D005080:Exercise Test; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050152:Intra-Abdominal Fat; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood* / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D006003:Glycogen; D054409:Nicotinamide Phosphoribosyltransferase