title: Anti-tumor immunity and mechanism of immunosuppression mediated by tumor cells: role of tumor-derived soluble factors and cytokines.
abstract: The immune system plays a crucial role in the protection against tumor growth and progression. However, the activation of the immune system against the neoplastic cells does not always occur and, therefore, tumor cells are able to grow and progress continually in the host. It has now been realized that tumor cells themselves produce many of the important factors that are responsible for dismounting of effective immune response. These tumor-derived soluble factors invariably subdue the functions of almost every immune cell population. Therefore, we attempted to underline the mechanism of anti-tumor immune response and immunosuppression induced by tumor cells.
authors.affiliation: Centre of Advance Study in Zoology, Faculty of Science, Banaras Hindu University, Varanasi, UP, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Deepak
authors.forename: Arbind
authors.initials: A
authors.lastname: Acharya
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007165:Immunosuppression Therapy; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D012995:Solubility
chemical_list: D016207:Cytokines; D009363:Neoplasm Proteins