Pulmonary alveolar proteinosis in a 67-year-old woman with Wegener's granulomatosis.
Mycophenolate mofetil (MM) is commonly used in patients with autoimmune diseases or who have undergone transplantation. Common side effects of MM include anemia, leukopenia, mucositis and opportunistic infections. We report an unusual case of pulmonary alveolar proteinosis (PAP) in a 67-year-old woman on MM for Wegener's granulomatosis (WG). PAP is a disease characterized by defects in macrophage-mediated processing of surfactants, leading to accumulation of periodic acid-Schiff (PAS)-positive lipoproteinaceous material within the alveolar spaces.
Shah
Shiwan K
SK
Departments of Internal Medicine and Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA. skshah@utmb.edu
Phan
Nghi B
NB
Goyal
Geetinder
G
Sharma
Gulshan
G
D000368:Aged; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
D016178:Granulocyte-Macrophage Colony-Stimulating Factor