[Melatonin in the combined treatment of cardiovascular diseases].
The aim of the work was to assess effectiveness of melatonin monotherapy (MT) and combined treatment (CT) in aged patients with arterial hypertension (AH) and coronary heart disease (CHD). A group of 170 patients (mean age 64 years) included 61 ones with CHD and 100 with AH. ECG, AP, and echoCG monitoring was performed before and 21 days after treatment along with clinical examination and evaluation of oxidative and antioxidative activities in erythrocytes. Treatment efficiency was compared in the study and randomized control groups. The data obtained suggest antihypertensive action of MT. CT with melatonin and antihypertensive drugs had better outcome than standard therapy in control groups. Inclusion of melatonin in CT of CHD produced marked anti-ischemic and anti-anginal effects and normalized oxidant/antioxidant balance. It is concluded that melatonin should be an important component of MT and CT of cardiovascular diseases.
Zaslavskaia
R M
RM
Shcherban'
E A
EA
Lilitsa
G V
GV
Logvinenko
S I
SI
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D004359:Drug Therapy, Combination; D015716:Electrocardiography, Ambulatory; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D015227:Lipid Peroxidation; D008550:Melatonin / Q000627:therapeutic use*; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D016877:Oxidants / Q000097:blood
D000959:Antihypertensive Agents; D000975:Antioxidants; D016877:Oxidants; D008550:Melatonin