NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies.
Metallo-ß-lactamases (MBL) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 ß-lactamase is the most commonly encountered MBL in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the ß-lactam, imipenem, in E. coli.
Weide
Timo
T
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA.
Saldanha
S Adrian
SA
Minond
Dmitriy
D
Spicer
Timothy P
TP
Fotsing
Joseph R
JR
Spaargaren
Michael
M
Frère
Jean-Marie
JM
Bebrone
Carine
C
Sharpless
K Barry
KB
Hodder
Peter S
PS
Fokin
Valery V
VV