Regulation of immune cell homeostasis by type I interferons.
Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular proliferation and survival. Here, we review the influence of IFN-I on immune cell homeostasis, focusing on their effects on T cells and antigen-presenting cells.
Mattei
Fabrizio
F
Dept. of Cell Biology and Neurosciences, Instituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. fabrizio.mattei@iss.it
Schiavoni
Giovanna
G
Tough
David F
DF
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D000998:Antiviral Agents / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000998:Antiviral Agents; D007370:Interferon Type I