title: Selective fluorescence detection of cysteine and N-terminal cysteine peptide residues.
abstract: A new fluorogenic fluorescein derivative containing an alpha,beta-unsaturated aldehyde moiety produces a selective fluorescent signal enhancement in the presence of cysteine or peptides containing N-terminal cysteine residues. The mechanism is based on synergistic covalent and supramolecular interactions.
authors.affiliation: Department of Chemistry, Portland State University, Portland, Oregon 97207, USA.
authors.forename: Soojin
authors.initials: S
authors.lastname: Lim
authors.forename: Jorge O
authors.initials: JO
authors.lastname: Escobedo
authors.forename: Mark
authors.initials: M
authors.lastname: Lowry
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Xu
authors.forename: Robert
authors.initials: R
authors.lastname: Strongin
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D003545:Cysteine / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D000447:Aldehydes; D010455:Peptides; D003545:Cysteine