title: Cytotoxic triterpenoids from Ganoderma lucidum.
abstract: A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them (1-6) are hitherto unknown. The structures of the latter were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Chun-Ru
authors.initials: CR
authors.lastname: Cheng
authors.forename: Qing-Xi
authors.initials: QX
authors.lastname: Yue
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Wu
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Song
authors.forename: Si-Jia
authors.initials: SJ
authors.lastname: Tao
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Wu
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Xu
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D020940:Reishi / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes