Differential resistance to oxidants and production of hydrolytic enzymes in Candida albicans.
Resistance to the toxic effects of reactive oxygen species produced by phagocytes and production of hydrolytic enzymes are important aspects of Candida albicans virulence. In this report, we compared twelve C. albicans isolates for their in vitro capacity to resist oxidants-hydrogen peroxide, menadione and paraquat; and to produce hydrolytic enzymes-phospholipase and protease. Different C. albicans isolates showed different degrees of resistance to oxidants as well as differences in production of hydrolytic enzymes. Resistance to oxidative stress did not correlate with production of hydrolytic enzymes. This reinforces the view that C. albicans differentially regulates the expression of virulence factors in response to local environmental conditions.
Abegg
Maxwel A
MA
Universidade Paranaense, UNIPAR, Toledo, PR, Brazil.
Lucietto
Rodrigo
R
Alabarse
Paulo V G
PV
Mendes
Marcus F A
MF
Benfato
Mara Silveira
MS
D000935:Antifungal Agents / Q000633:toxicity*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology*; D025141:Drug Resistance, Fungal; D004798:Enzymes / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000633:toxicity; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D016877:Oxidants / Q000633:toxicity*; D010269:Paraquat / Q000633:toxicity; D024483:Vitamin K 3 / Q000633:toxicity
D000935:Antifungal Agents; D004798:Enzymes; D005656:Fungal Proteins; D016877:Oxidants; D024483:Vitamin K 3; D006861:Hydrogen Peroxide; D010269:Paraquat