title: Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy.
abstract: In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4 T-cell counts less than 350 microl were distinct from HIV-infected individuals with more than 350 CD4 T-cell counts/microl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-gamma-secreting CD4 T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.
authors.affiliation: Department of Biomedicine, Basel University, Switzerland.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Fritz
authors.forename: Erik
authors.initials: E
authors.lastname: Mossdorf
authors.forename: Bojana
authors.initials: B
authors.lastname: Durovic
authors.forename: Gabriela
authors.initials: G
authors.lastname: Zenhaeusern
authors.forename: Anna
authors.initials: A
authors.lastname: Conen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Steffen
authors.forename: Manuel
authors.initials: M
authors.lastname: Battegay
authors.forename: Reto
authors.initials: R
authors.lastname: Nüesch
authors.forename: Christoph
authors.initials: C
authors.lastname: Hess
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines