Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line.
The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERbeta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.
Bhatnagar
Seema
S
Chemical Synthesis Group, Amity Institute of Biotechnology, Amity University Sector 125, Noida, India. sbhatnagar@aib.amity.edu
Sahi
Shakti
S
Kackar
Puneet
P
Kaushik
Swati
S
Dave
Manan K
MK
Shukla
Akshara
A
Goel
Ashita
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001665:Binding Sites; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D003198:Computer Simulation; D015195:Drug Design; D047629:Estrogen Receptor beta / Q000737:chemistry; D005260:Female; D006801:Humans; D013343:Styrenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013816:Thermodynamics
D000970:Antineoplastic Agents; D001578:Benzopyrans; D002867:Chromones; D047629:Estrogen Receptor beta; D013343:Styrenes