The chromosomal translocation (11;14) (p13; q11) in acute B-Cell lymphocytic leukemia.
BACKGROUND
Cytogenetic abnormalities are the most important independent prognostic factors of acute leukemia and imply the potential molecular mechanism of the disease. Translocation (11;14)(p13;q11) has been predominantly found in T-cell acute lymphocytic leukemia (ALL) but is rare in B-cell ALL.


METHODS
We present the case of a 30-year-old male patient, who presented with symptomatic anemia, thrombocytopenia and leukocytosis. Bone marrow aspirate smear showed hypercellularity with 90.4% of blast cells, which were negative for peroxidase reaction and partially positive for periodic acid-Schiff reaction. Immunophenotyping analysis was positive for CD34, HLA-DR, CD13, CD33, CD19, CD22, cCD79c, and negative for CD2, CD3, CD7, CD8, CD10, CD20, cCD3. Conventional cytogenetic study by R-banding showed complex chromosome aberrations involving t(11;14)(p13;q11) with the following karyotype: 46,XY,t (11;14)(p13;q11)[2]/46,idem,add2(q?)[2]/46,XY,add16(p?) [3]/46,XY[13]. Fluorescence in situ hybridization analysis indicated the translocation of chromosomes 11 and 14, and was negative for BCR/ABL fusion. The patient went into complete remission after the first induction chemotherapy (ALL-IC-BFM 2002 regimen), but he relapsed and died after 4 months.


CONCLUSIONS
Translocation (11;14) (p13;q11) in B-cell ALL is rare, but it is worth exploring the molecular mechanisms and discovering the prognostic value in more B-cell ALL patients.
Miao
Kourong
K
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, China.
Li
Jianyong
J
Qiu
Hairong
H
Zhang
Run
R
Chen
Lijuan
L
Wu
Hanxin
H
Wang
Rong
R
Zhang
Jianfu
J
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015448:Leukemia, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D011379:Prognosis; D012074:Remission Induction; D014178:Translocation, Genetic / Q000235:genetics*