[Karyomegalic interstitial nephritis: A new French case].
Karyomegalic interstitial nephritis (KIN) is a rare and slowly progressive chronic interstitial nephritis (CIN) (28 cases reported), described for the first time by Mihatsch et al. in 1979. Here, we report on a 50-year-old woman who presented with asymptomatic renal failure and mild proteinuria without hematuria. Renal biopsy showed large tubulo-interstitial fibrosis and massively enlarged tubular epithelial cell nuclei, without viral inclusion. KIN is a rare CIN defined by a karyomegaly of tubular epithelial cell nuclei. Its pathogenesis remains obscure. Nevertheless, an exogenous factor is suspected, ochratoxin A particularly. The familial clustering of patients and the frequency of HLA-A9 and HLA-B35 haplotypes suggest the presence of a possible genetic susceptibility to this disorder.
Verine
Jérôme
J
hôpital Saint-Louis, AP-HP, Paris, France. jerome.verine@sls.aphp.fr
Reade
Richard
R
Janin
Anne
A
Droz
Dominique
D
D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology*