title: C-It: a knowledge database for tissue-enriched genes.
abstract: BACKGROUND
  Due to the development of high-throughput technologies such as microarrays, it has become possible to determine genome-wide expression changes in a single experiment. Although much attention has been paid to identify differentially expressed genes, the functions of tens of thousands of genes in different species still remain unknown.
  
  
  RESULTS
  C-It is a knowledge database that has its focus on 'uncharacterized genes'. C-It contains expression profiles of various tissues from human, mouse, rat, chicken and zebrafish. By applying our previously introduced algorithm DGSA (Database-Dependent Gene Selection and Analysis), it is possible to screen for uncharacterized, tissue-enriched genes in the species mentioned above. C-It is designed to include further expression studies, which might provide more comprehensive coverage of gene expression patterns and tissue-enriched splicing isoforms. We propose that C-It will be an excellent starting point to study uncharacterized genes.
  
  
  BACKGROUND
  C-It is freely available online without registration at http://C-It.mpi-bn.mpg.dehttp://C-It.mpi-bn.mpg.de.
authors.affiliation: Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
authors.forename: Pascal
authors.initials: P
authors.lastname: Gellert
authors.forename: Katharina
authors.initials: K
authors.lastname: Jenniches
authors.forename: Thomas
authors.initials: T
authors.lastname: Braun
authors.forename: Shizuka
authors.initials: S
authors.lastname: Uchida
mesh_terms: D000465:Algorithms; D000818:Animals; D030541:Databases, Genetic; D020224:Expressed Sequence Tags; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D020407:Internet; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D014584:User-Computer Interface; D015027:Zebrafish