All roads lead to the ribosome.
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key integrator of protein synthesis downstream of the ERK and AKT signaling pathways, providing an intriguing rationale for why their simultaneous targeting could enhance therapeutic efficacy.
Whittaker
Steven
S
Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
Martin
Matthew
M
Marais
Richard
R