title: The needs of the few.
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods; D017277:Drug Approval / Q000331:legislation & jurisprudence / Q000379:methods*; D004345:Drug Industry / Q000331:legislation & jurisprudence / Q000458:organization & administration; D006801:Humans; D035583:Rare Diseases / Q000188:drug therapy*; D018401:Sample Size; D014481:United States; D014486:United States Food and Drug Administration / Q000331:legislation & jurisprudence