title: Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine.
abstract: The intermittent administration of methamphetamine produces behavioral sensitization to methamphetamine. In the limbic forebrain, mainly including the nucleus accumbens, of mice that had been intermittently treated with methamphetamine, we found a significant increase in mRNA of a chemokine, CCR2. This increase was accompanied by a significant increase in histone H3 lysine 4 (H3K4) trimethylation at its promoter. Interestingly, the maintenance of sensitization to methamphetamine-induced hyperlocomotion was significantly decreased in CCR2 knockout mice. These findings suggest that increased CCR2 associated with epigenetic modification after the intermittent administration of methamphetamine may be associated with the maintenance of sensitization to methamphetamine-induced hyperlocomotion.
authors.affiliation: Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Ikegami
authors.forename: Minoru
authors.initials: M
authors.lastname: Narita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Imai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Miyashita
authors.forename: Rie
authors.initials: R
authors.lastname: Tamura
authors.forename: Michiko
authors.initials: M
authors.lastname: Narita
authors.forename: Shigemi
authors.initials: S
authors.lastname: Takagi
authors.forename: Akiko
authors.initials: A
authors.lastname: Yokomizo
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takeshima
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ando
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Igarashi
authors.forename: Jun
authors.initials: J
authors.lastname: Kanno
authors.forename: Naoko
authors.initials: N
authors.lastname: Kuzumaki
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Ushijima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D044127:Epigenesis, Genetic / Q000235:genetics*; D008032:Limbic System / Q000187:drug effects; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects* / Q000235:genetics*; D009714:Nucleus Accumbens / Q000187:drug effects; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*; D054390:Receptors, CCR2 / Q000235:genetics*
chemical_list: C515335:Ccr2 protein, mouse; D000697:Central Nervous System Stimulants; D012333:RNA, Messenger; D054390:Receptors, CCR2; D008694:Methamphetamine