title: Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change.
abstract: OBJECTIVE
  Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting.
  
  
  METHODS
  Fifteen patients were enrolled in each group. Liver function tests were done; also, grade of steatosis and pattern of echogenicity of the liver were determined. Patients were followed up by the same evaluation repeated in first, second and third months.
  
  
  RESULTS
  Mean age +/- standard deviation was 43.2 +/- 10.3 years. Grape seed extract (GSE) significantly improved the grade of fatty liver change; and resulted in significant decrease in alanine aminotransferase in patients receiving the concentrate compared to those receiving vitamin C independently, from the initial grade of steatosis.
  
  
  CONCLUSIONS
  This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.
authors.affiliation: Department of Drug Applied Research Center, Tabriz University of Medical Sciences, Iran.
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Khoshbaten
authors.forename: Akbar
authors.initials: A
authors.lastname: Aliasgarzadeh
authors.forename: Koorosh
authors.initials: K
authors.lastname: Masnadi
authors.forename: Sara
authors.initials: S
authors.lastname: Farhang
authors.forename: Mohammad K
authors.initials: MK
authors.lastname: Tarzamani
authors.forename: Hosain
authors.initials: H
authors.lastname: Babaei
authors.forename: Javad
authors.initials: J
authors.lastname: Kiani
authors.forename: Maryam
authors.initials: M
authors.lastname: Zaare
authors.forename: Farzad
authors.initials: F
authors.lastname: Najafipoor
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D000704:Analysis of Variance; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005234:Fatty Liver / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D056604:Grape Seed Extract / Q000627:therapeutic use*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D056604:Grape Seed Extract; D000410:Alanine Transaminase; D001205:Ascorbic Acid