title: Secondary lymphoma involving metastatic follicular thyroid carcinoma to the skull: a unique example of tumor-to-tumor metastasis.
abstract: Tumor-to-tumor metastases to the skull, presenting as a scalp mass, and thyroid follicular carcinoma presenting in that location are extremely rare. We present the case of a patient with recently diagnosed retroperitoneal diffuse large B-cell lymphoma and an 8-year history of a non-tender large scalp-based mass. The scalp mass was an osteolytic enhancing lesion on imaging studies and diagnosed as metastatic thyroid carcinoma to the skull. The patient had no pre-existing history of thyroid cancer. This metastatic carcinoma was also secondarily involved with diffuse large B-cell lymphoma. This case illustrates a unique and previously unreported example of tumor-to-tumor metastasis in which both malignancies represent metastatic tumors to the skull with soft tissue extension presenting as a large scalp mass.
authors.affiliation: Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 63110, USA. jlu@path.wustl.edu
authors.forename: Ji
authors.initials: J
authors.lastname: Lu
authors.forename: John L
authors.initials: JL
authors.lastname: Frater
authors.forename: Friederike H
authors.initials: FH
authors.lastname: Kreisel
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Marcus
authors.forename: Anjum
authors.initials: A
authors.lastname: Hassan
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D016879:Salvage Therapy; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy