title: Leptospirosis.
abstract: This article forms part of our travel medicine series for 2010, providing a summary of prevention strategies and vaccination for infections that may be acquired by travellers. The series aims to provide practical strategies to assist general practitioners in giving travel advice, as a synthesis of multiple information sources which must otherwise be consulted.
  
  
  BACKGROUND
  Leptospirosis is one of the many diseases responsible for undifferentiated febrile illness, especially in the tropical regions or in the returned traveller. It is a disease of global importance, and knowledge in the disease is continually developing.
  
  
  OBJECTIVE
  The aim of this article is to provide clinicians with a concise review of the epidemiology, pathophysiology, clinical features, diagnosis, management and prevention of leptospirosis.
  
  
  CONCLUSIONS
  Leptospirosis should be included in the broad differential diagnosis of febrile illness. The clinical manifestations of the disease vary from mild, nonspecific illness through to severe illness resulting in acute renal failure, hepatic failure and pulmonary haemorrhage. Diagnosis is dependant on accurate prediction of the time of infection: culture, polymerase chain reaction and serology may be used to confirm the diagnosis. Management is centred on prompt antibiotic therapy using doxycycline or intravenous penicillin G or intravenous ceftriaxone/cefotaxime. Prevention of leptospirosis revolves around the 'cover-wash-clean up' strategy.
authors.affiliation: Griffith University, Gold Coast, Queensland. at.slack@gmail.com
authors.forename: Andrew
authors.initials: A
authors.lastname: Slack
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D003937:Diagnosis, Differential; D014943:Global Health; D006801:Humans; D007922:Leptospirosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011315:Preventive Medicine; D011634:Public Health; D012307:Risk Factors; D014330:Tropical Medicine
chemical_list: D000900:Anti-Bacterial Agents