Expression and regulation in the brain of the chemokine CCL27 gene locus.
The chemokine CCL27 has chemoattractant properties for memory T cells and has been implicated in skin allergic reactions. The present study reports the expression in the brain of two CCL27 splice variants localized in the cerebral cortex and limbic regions. CCL27-like immunoreactivity was identified mainly in neurons. Variant 1 was found elevated in the olfactory bulbs during allergic inflammation induced by intranasal challenge with allergen. This was accompanied by the presence of T cells in the olfactory bulbs. Intranasal administration of neutralizing antibodies against CCL27 reduced the presence of T cells in the olfactory bulbs suggesting a function in T cell activity in the brain.
Gunsolly
Chad
C
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201-1549, USA.
Nicholson
James D
JD
Listwak
Samuel J
SJ
Ledee
Dolena
D
Zelenka
Peggy
P
Verthelyi
Daniela
D
Chapoval
Svetlana
S
Keegan
Achsah
A
Tonelli
Leonardo H
LH
D000418:Albumins / Q000009:adverse effects / Q000276:immunology; D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D017252:CD3 Complex / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D054425:Chemokine CCL27 / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology*; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism
D000418:Albumins; D017252:CD3 Complex; D054425:Chemokine CCL27; D020033:Protein Isoforms; D012333:RNA, Messenger