title: Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity.
abstract: In vivo and in vitro investigations of GilP and GilQ, two acyltransferases encoded by the gilvocarcin gene cluster, show that GilQ confers unique starter unit specificity when catalyzing an early as well as rate limiting step of gilvocarcin biosynthesis.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA.
authors.forename: Micah D
authors.initials: MD
authors.lastname: Shepherd
authors.forename: Madan K
authors.initials: MK
authors.lastname: Kharel
authors.forename: Lili L
authors.initials: LL
authors.lastname: Zhu
authors.forename: Steven G
authors.initials: SG
authors.lastname: van Lanen
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rohr
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry*; D006027:Glycosides / Q000096:biosynthesis* / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D048170:Streptomyces lividans / Q000737:chemistry* / Q000201:enzymology*; D013379:Substrate Specificity
chemical_list: D003374:Coumarins; D006027:Glycosides; C031781:gilvocarcin V; D000217:Acyltransferases