Incidence of multiple Herpesvirus infection in HIV seropositive patients, a big concern for Eastern Indian scenario.
BACKGROUND
Human immunodeficiency virus (HIV) infection is associated with an increased risk for human herpes viruses (HHVs) and their related diseases and they frequently cause disease deterioration and therapeutic failures. Methods for limiting the transmission of HHVs require a better understanding of the incidence and infectivity of oral HHVs in HIV-infected patients. This study was designed to determine the seroprevalence of human herpes viruses (CMV, HSV 2, EBV-1, VZV) antibodies and to evaluate their association with age, sex as well as other demographic and behavioral factors.


RESULTS
A study of 200 HIV positive patients from Eastern India attending the Calcutta Medical College Hospital, Kolkata, West Bengal, Apex Clinic, Calcutta Medical College Hospital and ART Center, School of Tropical Medicine, Kolkata, West Bengal was done. Serum samples were screened for antibodies to the respective viruses using the indirect ELISA in triplicates.CytoMegalo virus (CMV), Herpes Simplex virus type 2 (HSV-2), Varicella Zoster virus (VZV), and Epstein Barr virus (EBV-1) were detected in 49%, 47%, 32.5%, and 26% respectively.


CONCLUSIONS
This study has contributed baseline data and provided insights in viral OI and HIV co-infection in Eastern India. This would undoubtedly serve as a basis for further studies on this topic.
Chakraborty
Nilanjan
N
Virology Department, ICMR Virus Unit, ID & BG Hospital, GB4, 57 Dr. SC Banerjee Road Beliaghata, Kolkata, India. nilanjanchakraborty@ymail.com
Bhattacharyya
Sohinee
S
De
Chandrav
C
Mukherjee
Anirban
A
Bhattacharya
Dwipayan
D
Santra
Shantanu
S
Sarkar
Rathindra N
RN
Banerjee
Dipanjan
D
Guha
Shubhasish K
SK
Datta
Utpal K
UK
Chakrabarti
Sekhar
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology / Q000821:virology; D006564:Herpesviridae / Q000276:immunology / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology / Q000821:virology; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D000914:Antibodies, Viral; D015483:HIV Antibodies