Anti-Ku antibodies: Clinical, genetic and diagnostic insights.
Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.
Belizna
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Internal Medicine Department, University Hospital Angers, France. cristina.belizna@wanadoo.fr
Henrion
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Beucher
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Lavigne
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Ghaali
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Lévesque
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D034961:Antigens, Nuclear / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D051747:DNA-Activated Protein Kinase / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D000072200:Ku Autoantigen; D009687:Nuclear Proteins / Q000378:metabolism; D015995:Prevalence; D044469:Racial Groups; D012307:Risk Factors
D034961:Antigens, Nuclear; D001323:Autoantibodies; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen