Cancer cell specific gene delivery by laminin-derived peptide AG73-labeled liposomes.
We developed laminin-derived AG73 peptide labeled liposomes for cancer specific gene therapy. AG73 peptide is well known as a ligand for syndecan-2 which is highly expressed in various cancer cells. Liposomes labeled with AG73 showed high efficient transfection efficiency in syndecan-2 overexpressing cells, and found that AG73 could be a superior molecule in the development of non-viral vector using liposomes for the gene delivery to syndecan-2 overexpressing cancer cells.
Iijima
Hiroshi
H
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
Negishi
Yoichi
Y
Omata
Daiki
D
Nomizu
Motoyoshi
M
Aramaki
Yukihiko
Y
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002460:Cell Line; D006801:Humans; D007797:Laminin / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D053669:Syndecan-2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D014162:Transfection
D000970:Antineoplastic Agents; D007797:Laminin; D008081:Liposomes; D010455:Peptides; D053669:Syndecan-2