title: Aortic valve bypass for aortic stenosis in a patient with paroxysmal nocturnal hemoglobinuria.
abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.
authors.affiliation: Department of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland, USA.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Ghoreishi
authors.forename: Maria R
authors.initials: MR
authors.lastname: Baer
authors.forename: Ranjana
authors.initials: R
authors.lastname: Bhargava
authors.forename: Craig E
authors.initials: CE
authors.lastname: Stauffer
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
authors.forename: James S
authors.initials: JS
authors.lastname: Gammie
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D008297:Male