Cameroonemide A: a new ceramide from Helichrysum cameroonense.
From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), beta-sitosterol (4), and beta-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.
Antoine
Kakam Zanetsie
KZ
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Hussain
Hidayat
H
Dongo
Etienne
E
Kouam
Simeon F
SF
Schulz
Barbara
B
Krohn
Karsten
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects*; D002163:Cameroon; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036562:Helichrysum / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000900:Anti-Bacterial Agents; D002518:Ceramides; C551222:cameroonemide A