title: Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.
abstract: Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain. pbb@usal.es
authors.forename: P
authors.initials: P
authors.lastname: Basabe
authors.forename: M
authors.initials: M
authors.lastname: de Román
authors.forename: I S
authors.initials: IS
authors.lastname: Marcos
authors.forename: D
authors.initials: D
authors.lastname: Diez
authors.forename: A
authors.initials: A
authors.lastname: Blanco
authors.forename: O
authors.initials: O
authors.lastname: Bodero
authors.forename: F
authors.initials: F
authors.lastname: Mollinedo
authors.forename: B G
authors.initials: BG
authors.lastname: Sierra
authors.forename: J G
authors.initials: JG
authors.lastname: Urones
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D013057:Spectrum Analysis
chemical_list: D000098:Acetophenones; D000970:Antineoplastic Agents; D005419:Flavonoids; C038699:acetophenone