Molecular imaging of angiogenesis with SPECT.
Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine. SPECT imaging is more widely available than PET imaging and the radionuclides used for SPECT are easier to prepare and usually have a longer half-life than those used for PET. In addition, SPECT is a less expensive technique than PET. Commonly used gamma emitters are: (99m)Tc (E(max) 141 keV, T (1/2) 6.02 h), (123)I (E(max) 529 keV, T (1/2) 13.0 h) and (111)In (E(max) 245 keV, T (1/2) 67.2 h). Compared to clinical SPECT, PET has a higher spatial resolution and the possibility to more accurately estimate the in vivo concentration of a tracer. In preclinical imaging, the situation is quite different. The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm). In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed.
Dijkgraaf
Ingrid
I
Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands. I.Dijkgraaf@nucmed.umcn.nl
Boerman
Otto C
OC
D000818:Animals; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D016326:Extracellular Matrix Proteins; D039302:Integrin alphaVbeta3; D040262:Receptors, Vascular Endothelial Growth Factor; D017430:Prostate-Specific Antigen