Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.
This study investigated antipruritic and anti-inflammatory effect of Centella asiatica extract in rats and anti-allergic in vitro using sheep (Capra hircus) serum method and compound 48/80 induced mast cell degranulation method, compared with standard drug ketotifen fumarate. In rats, extract of Centella asiatica administered orally was examined for anti-pruritic study and chlorpheniramine maleate was used as standard drug while carageenan paw induced inflammatory method was used for the antiinfammatory study. The results show that the extracts of Centella asiatica exhibited antiallergic, anti-pruritic and anti-inflammatory activities.
George
Mathew
M
Mekelle University, Mekelle, Ethiopia. mathewlincg@yahoo.com
Joseph
Lincy
L
Ramaswamy
D000284:Administration, Oral; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000982:Antipruritics / Q000494:pharmacology / Q000627:therapeutic use*; D028041:Centella; D002744:Chlorpheniramine / Q000627:therapeutic use; D007665:Ketotifen; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D014315:Triterpenes / Q000627:therapeutic use*; D003189:p-Methoxy-N-methylphenethylamine
D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D000982:Antipruritics; C526146:Centella asiatica extract; D010936:Plant Extracts; D014315:Triterpenes; D002744:Chlorpheniramine; D003189:p-Methoxy-N-methylphenethylamine; D007665:Ketotifen