title: Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain.
abstract: Accumulating evidence indicates that the endocannabinoid system plays an essential role in the development and maturation of the central nervous system. Studies also have demonstrated that neural systems that regulate behavioral responses can be influenced by exercise during development. Exercise and endogenous cannabinoid activity have independently been shown to regulate brain plasticity, hence demonstrating a promising field of the endocannabinoid-exercise interaction. In order to investigate whether physical exercise during development would promote changes the brain endocannabinoid system, we investigated the cannabinoid receptor type 1 (CB1) expression in the brain of rats trained during the adolescent period. The results showed that an aerobic exercise program performed during adolescence significantly reduced the CB1 receptor expression in the striatum and hippocampal formation. These findings suggest an important link between the endocannabinoid system and physical training in adolescence.
authors.affiliation: Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. sergio.gomes@unifesp.br
authors.forename: Sérgio
authors.initials: S
authors.lastname: Gomes da Silva
authors.forename: Bruno Henrique Silva
authors.initials: BH
authors.lastname: Araujo
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Cossa
authors.forename: Fulvio Alexandre
authors.initials: FA
authors.lastname: Scorza
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
authors.forename: Maria da Graça
authors.initials: Mda G
authors.lastname: Naffah-Mazzacoratti
authors.forename: Ricardo Mario
authors.initials: RM
authors.lastname: Arida
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D015153:Blotting, Western; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry / Q000502:physiology*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000378:metabolism; D006624:Hippocampus / Q000033:anatomy & histology / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000096:biosynthesis*
chemical_list: D043884:Receptor, Cannabinoid, CB1