title: Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study.
abstract: Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on threat intensity in patients with generalized social phobia (GSP) and healthy controls. GSP patients exhibited greater amygdala reactivity to threat faces at high and moderate intensities. More subtle displays of social threat are sufficient to evoke a fear-related neural response.
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109-2700, United States. heidek@umich.edu
authors.forename: Heide
authors.initials: H
authors.lastname: Klumpp
authors.forename: Mike
authors.initials: M
authors.lastname: Angstadt
authors.forename: Pradeep J
authors.initials: PJ
authors.lastname: Nathan
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
mesh_terms: D000328:Adult; D000679:Amygdala / Q000098:blood supply*; D001931:Brain Mapping; D005145:Face; D005149:Facial Expression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010698:Phobic Disorders / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D010775:Photic Stimulation / Q000379:methods; D055815:Young Adult
chemical_list: D010100:Oxygen