title: Clinical implications of non-invasive measurement of central aortic blood pressure.
abstract: Central arterial systolic blood pressure is a very important factor in the pathophysiology of cardiovascular diseases. Central arterial pressure is a better predictor of cardiovascular risk than peripheral brachial blood pressure. Measurement of central blood pressure is useful for a diagnosis of spurious systolic hypertension in young people. Antihypertensive drugs have a different impact on central blood pressure, for example angiotensin converting enzyme inhibitors, antagonists of angiotensin II receptors, calcium channel blockers more effectively lower central blood pressure than betablockers, despite all of those drugs (including beta-blockers) having a similar impact on peripheral pressure. This mechanism may be responsible for the beneficial effect of some antihypertensive drugs on cardiovascular end points observed in clinical trials, despite a low peripheral hypotensive effect. However, further clinical trials are required to provide more evidence for the prognostic and therapeutic implications of the measurement of central blood pressure before adopting its routine application in clinical practice.
authors.affiliation: Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Stepień
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
authors.forename: Piotr
authors.initials: P
authors.lastname: Jankowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
mesh_terms: D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination / Q000379:methods*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology; D002406:Catheterization, Peripheral; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D012306:Risk; D013599:Systole; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents