title: Phosphine-catalyzed asymmetric additions of malonate esters to {gamma}-substituted allenoates and allenamides.
abstract: Because carbonyl groups are ubiquitous in organic chemistry, the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straightforward and versatile method for catalytic asymmetric carbon-carbon bond formation at the γ-position of carbonyl compounds, specifically, phosphine-catalyzed additions of malonate esters to γ-substituted allenoates and allenamides. Mechanistic studies have provided insight into the reaction pathway.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Sinisi
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Fu