title: Transcoronary bone marrow-derived progenitor cells in a child with myocardial infarction: first pediatric experience.
abstract: BACKGROUND
  Recent advances in stem cell therapy to restore cardiac function have great promise for patients with congestive heart failure after myocardial infarction in an adult population.
  
  
  OBJECTIVE
  We examined the benefits of bone marrow-derived progenitor cells treatment modality for the pediatric patient.
  
  
  RESULTS
  We present our first case of transcoronary autologous stem cell transplantation in a 9-year-old girl with refractory congestive heart failure secondary to myocardial infarction 1 year after transcatheter revascularization. The child received daily injections of granulocyte colony-stimulating factor for 3 days prior to the bone marrow aspiration. The bone marrow cells were isolated to constitute CD133+/CD34+ more than 90% of the total number. Subsequently, the progenitor cell suspension was injected via a transcoronary catheter without any complication. Three months after stem cell therapy, her cardiac function, assessed by both cardiac magnetic resonance and echocardiogram, has been improved with the left ventricular ejection fraction at 47% compared to the baseline of 30%.
  
  
  CONCLUSIONS
  This is the first reported pediatric case of successful transcoronary injection of bone marrow-derived progenitor cells for end-stage heart disease. The procedure is considered safe and feasible for the pediatric population.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. alimsuwan@yahoo.com
authors.forename: Alisa
authors.initials: A
authors.lastname: Limsuwan
authors.forename: Pavit
authors.initials: P
authors.lastname: Pienvichit
authors.forename: Thosaphol
authors.initials: T
authors.lastname: Limpijankit
authors.forename: Pongsak
authors.initials: P
authors.lastname: Khowsathit
authors.forename: Suradej
authors.initials: S
authors.lastname: Hongeng
authors.forename: Ratanaporn
authors.initials: R
authors.lastname: Pornkul
authors.forename: Suvipaporn
authors.initials: S
authors.lastname: Siripornpitak
authors.forename: Sarana
authors.initials: S
authors.lastname: Boonbaichaiyapruk
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D001854:Bone Marrow Cells / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000379:methods*; D006328:Cardiac Catheterization; D002469:Cell Separation / Q000379:methods; D002648:Child; D004452:Echocardiography; D005260:Female; D005434:Flow Cytometry; D006023:Glycoproteins / Q000032:analysis; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D010455:Peptides / Q000032:analysis; D020127:Recovery of Function; D033581:Stem Cell Transplantation / Q000379:methods*; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides; D016179:Granulocyte Colony-Stimulating Factor