title: Benign nodular goiter with spindle cell component.
abstract: We report three benign nodular goiters associated with spindle cell component. The spindle cells were bland, and showed short fascicular pattern or formed small nests. The cytoplasm was pale or clear. A transition between follicular cells and the spindle cells was observed. Immunohistochemically, they were positive for thyroglobulin and thyroid transcription factor-1. They did not react against CD34. Ki-67 (MIB-1) labeling indexes were less than 1%. We thought that the spindle cells are derived from follicular cell and non-neoplastic, and it is important to recognize this lesion to distinguish from aggressive and lethal components seen in papillary carcinoma or anaplastic carcinoma.
authors.affiliation: Department of Diagnostic Pathology, Kuma Hospital, Kobe, Japan. mhirokawa@kuma-h.or.jp
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hirokawa
authors.forename: Reiji
authors.initials: R
authors.lastname: Haba
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.forename: Kenji
authors.initials: K
authors.lastname: Bando
authors.forename: Seiji
authors.initials: S
authors.lastname: Kuma
authors.forename: Minoru
authors.initials: M
authors.lastname: Kihara
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D005260:Female; D006044:Goiter, Nodular / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery