title: Second primary cancers following borderline ovarian tumors.
abstract: BACKGROUND
  Several studies have reported an increased risk of second primary cancers subsequent to invasive epithelial ovarian cancer. However, there is no adequate data regarding such risk in borderline ovarian tumors (BOTs). The aim of this study was to evaluate the risk of subsequent second primary cancers among women with BOTs.
  
  
  METHODS
  BOT patients treated in our center between December 1985 and April 2009 were retrospectively screened for developing second primary cancer during follow-up period.
  
  
  RESULTS
  There were 96 women diagnosed with BOT. Mean age at the time of diagnosis was 47 ± 14.3, ranging from 19 to 79. Eighty-eight (91.6%) patients had stage I disease, two patients (2.1%) had stage II and six (6.2%) had stage III. Twenty-five (26.0%) patients received platinum-based adjuvant chemotherapy. Mean follow-up time was 96.5 ± 442 months (range: 9-280 months). There were ten (10.4%) recurrences. Only one patient developed second primary cancer. Second primary cancer observed in this case was basal cell carsinoma of the eyelid, which was diagnosed 2 years after primary disease. There were no patients with common women's cancers such as breast and colorectal cancers.
  
  
  CONCLUSIONS
  These findings do not suggest increased risk of subsequent cancers in patients with BOT. However, population-based studies are needed for evaluating exact risk of developing second primary malignancies in women with BOTs.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ege Gynecology and Maternity Training and Research Hospital, Yenisehir, Izmir, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Sanci
authors.forename: Emre
authors.initials: E
authors.lastname: Gultekin
authors.forename: Basak
authors.initials: B
authors.lastname: Cingillioglu
authors.forename: Ozge Elmastas
authors.initials: OE
authors.lastname: Gultekin
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Ozvural
authors.forename: Volkan
authors.initials: V
authors.lastname: Emirdar
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yildirim
mesh_terms: D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000473:pathology; D000077216:Carcinoma, Ovarian Epithelial; D005142:Eyelid Neoplasms / Q000175:diagnosis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey; D055815:Young Adult