title: Antimicrobial resistance in Escherichia coli isolates from food animals, animal food products and companion animals in China.
abstract: One thousand and thirty Escherichia coli isolates from food animals, animals-derived foods, and companion animals between 2007 and 2008 in Southern China were used to investigate their antimicrobial susceptibility to 14 different antimicrobials by the standard agar dilution method. More than 70% of isolates showed resistance to tetracycline, trimethoprim-sulphamethoxazole, nalidixic acid, and ampicillin. In general, resistance was less frequent in companion animal isolates vs food animals isolates, but cephalosporin and amikacin resistance was more frequent in companion animal isolates, 42.6% to 56.2% vs 14.1% to 24.3%, and 28.5% vs 18.8%, respectively, which was most likely due to the common use of these antimicrobials as treatment in pet animals. Fluoroquinolones resistance was high in all animal isolates (>50%). Food products showed lowest resistance among isolates from these three resources. PFGE analysis indicated that a majority of multidrug-resistant E. coli isolates showed unique, unrelated PFGE profiles and were unlikely to be the spread of a specific clone. This study provides useful information about the prevalence of antimicrobial resistance in E. coli isolated from animals and food products in China and provided evidence of the linkage of the use of antimicrobials in animals and its selection of antimicrobial resistance in bacterial isolates. The data from this study further warns the prudent use of antimicrobials in food and pet animals to reduce the risks of transmission of antimicrobial resistance zoonotic pathogen to humans.
authors.affiliation: College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Wushan, Tianhe District, Guangzhou 510642, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Lei
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.forename: Liu
authors.initials: L
authors.lastname: He
authors.forename: Xian-Hui
authors.initials: XH
authors.lastname: Huang
authors.forename: Yong-Xue
authors.initials: YX
authors.lastname: Sun
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Dian-Hong
authors.initials: DH
authors.lastname: Lv
authors.forename: Cong-Ming
authors.initials: CM
authors.lastname: Wu
authors.forename: Liang-Zong
authors.initials: LZ
authors.lastname: Huang
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Shen
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000821:Animal Feed / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004358:Drug Therapy / Q000662:veterinary; D016521:Electrophoresis, Gel, Pulsed-Field / Q000662:veterinary; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D008460:Meat / Q000382:microbiology*; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D057805:Pets / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents