Evaluation and management of hyperlipidemia in children and adolescents.
OBJECTIVE
To review the recent findings on evaluation and management of dyslipidemia in childhood and adolescence, giving a critical view on new therapeutic approaches.


RESULTS
In 2008, the American Academy of Pediatrics released an updated policy statement recommending more frequent screening to detect dyslipidemia in childhood and the first-line use of statins in children with dyslipidemia who did not respond to lifestyle intervention and who were more than 8 years of age. These recommendations have caused a lot of controversy within the medical community and media. This debate is also sharpened by the fact that only few trials have investigated the long-term efficacy of statins on prevention of adult cardiovascular disease, their application in dyslipidemias other than familial hypercholesterolemia and the use of new pharmacological tools.


CONCLUSIONS
The purpose of our paper could not be achieved clearly without a review of the physiology of cholesterol metabolism together with an analysis of causes of primary and secondary dyslipidemia affecting children. Moreover, recent knowledge on lipid-lowering therapy is reviewed.
Iughetti
Lorenzo
L
Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy. iughetti.lorenzo@unimore.it
Bruzzi
Patrizia
P
Predieri
Barbara
B
D000293:Adolescent; D002648:Child; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008019:Life Style; D011379:Prognosis
D000960:Hypolipidemic Agents; D002784:Cholesterol