Comparison of in vitro fertilisation success in patients with polycystic ovary syndrome and tubal factor.
OBJECTIVE
This study is designed to compare the results of in vitro fertilisation (IVF) in polycystic ovary syndrome (PCOS) and tubal factor disorders.


METHODS
This was a cohort study performed in Royan Institute from 2007 to 2009. For this evaluation, 183 patients with PCOS and 183 patients with tubal factor (control group), whose ages ranged from 22 to 35 years underwent the long protocol of pituitary suppression and were included in the study.


RESULTS
In a defined time cycle, the number of ampoules used was higher for the control group (24.6 ± 0.9 versus 33.4 ± 0.9; p<0.0001). The PCOS group produced more oocytes (9.6 ± 0.5 versus 6.4 ± 0.3; p ≤ 0.0001) and embryos (3.7 ± 0.2 versus 2.7 ± 0.1; p=0.001). There were no significant differences in cancellation rate, the occurrence of ovarian hyperstimulation syndrome (OHSS) and cycles that resulted in lacked efficient follicle in the PCOS group and control group. Comparisons for biochemical pregnancy, implantation, clinical pregnancy and ongoing pregnancy rates showed no statistical difference. No significant differences were detected in miscarriage rates and complications.


CONCLUSIONS
The outcome of IVF in patients with PCOS and in patients with tubal infertility is similar.
Nejad
Ensieh Shahrokh Tehrani
ES
Endocrinology and Female Infertility Department, Reproductive Medicine Research Centre, Royan Institute, ACECR, Tehran, Iran. tehraninejad@royaninstitute.org
Saedi
Tahereh
T
Saedi
Sedigheh
S
Rashidi
Batool Hossein
BH
Nekoo
Zahra Azimi
ZA
Jahangiri
Nadia
N
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D005184:Fallopian Tube Diseases / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D016471:Ovarian Hyperstimulation Syndrome / Q000453:epidemiology; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome; D055815:Young Adult