Macrophage signaling pathways: a novel target in renal disease.
Monocytes/macrophages are a heterogeneous cell population that play a critical role in host defense and tissue homeostasis. However, macrophage activation during acute and chronic inflammation can result in macrophage-mediated renal injury in a variety of settings, including proliferative glomerulonephritis. Macrophages can be activated via a number of intracellular signaling pathways (eg, c-Jun amino terminal kinase, p38 mitogen-activated protein kinase, FcR/Syk, Janus kinase/signal transducer and activator of transcription) that induce production of mediators of renal injury. Thus, targeting selected macrophage signaling pathways is a potential therapeutic strategy to suppress macrophage-mediated renal injury while leaving intact the desirable macrophage functions of host defense and tissue repair.
Ma
Frank Y
FY
Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
Ikezumi
Yohei
Y
Nikolic-Paterson
David J
DJ
D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors; D007674:Kidney Diseases / Q000188:drug therapy* / Q000276:immunology*; D016173:Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D058990:Molecular Targeted Therapy; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors; D017452:Receptors, IgG / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects
D016207:Cytokines; D017452:Receptors, IgG; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor; D048031:JNK Mitogen-Activated Protein Kinases