Only the strong survive.
Whether apoptosis is relevant for interclonal competition of T cells after antigen encounter has remained uncertain. In this issue of Immunity, Wensveen et al. (2010) establish a critical role for the proapoptotic BH3-only protein Noxa in this selection process.
Villunger
Andreas
A
Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria. andreas.villunger@i-med.ac.at