title: Thermoluminescence dosimetry for skin dose assessment during intraoperative radiotherapy for early breast cancer.
abstract: Dosimetry for intraoperative radiotherapy (IORT) after wide local excision for breast cancer using a 50 kV X-ray needle (Intrabeam) was performed in vivo using thermoluminescence dosimetry. Eight LiF:Mg,Ti chips were placed on the skin around the incision site after wide local excision while the tumour bed was irradiated to a prescribed dose of 5 Gy 10 mm from the applicator surface. The maximum and mean measured skin dose for 57 patients ranged from 0.64 to 7.1 Gy and 0.56 to 4.78 Gy, respectively, reflecting different tissue thicknesses overlying the applicator. The average maximum dose of 2.93+/-1.46 Gy was below the threshold for severe radiation skin toxicity.
authors.affiliation: Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia. Penny.Fogg@premion.com.au
authors.forename: P
authors.initials: P
authors.lastname: Fogg
authors.forename: K R
authors.initials: KR
authors.lastname: Das
authors.forename: T
authors.initials: T
authors.lastname: Kron
authors.forename: C
authors.initials: C
authors.lastname: Fox
authors.forename: B
authors.initials: B
authors.lastname: Chua
authors.forename: J
authors.initials: J
authors.lastname: Hagekyriakou
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012867:Skin / Q000528:radiation effects; D013819:Thermoluminescent Dosimetry