Synthesis of 5-aryl-1,3-dimethyl-6-(alkyl- or aryl-amino) furo [2,3-d]pyrimidine derivatives by reaction between isocyanides and pyridinecarbaldehydes in the presence of 1,3-dimethylbarbituric acid.
5-Aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives were obtained by in situ reaction alkyl or aryl isocyanides and pyridinecarbaldehyde derivatives in the presence of 1,3-dimethylbarbituric acid in dichloromethane without any prior activation or modifications.
Maghsoodlou
Malek Taher
MT
Department of Chemistry, The University of Sistan & Baluchestan, P. O. Box 98135-674, Zahedan, Iran. mt_maghsoodlou@yahoo.com
Marandi
Ghasem
G
Hazeri
Nourallah
N
Habibi-Khorassani
Sayyed Mostafa
SM
Mirzaei
Ali Akbar
AA
D000447:Aldehydes / Q000737:chemistry*; D001463:Barbiturates / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
D000447:Aldehydes; D001463:Barbiturates; D003486:Cyanides; D011743:Pyrimidines; C018924:1,3-dimethylbarbituric acid; C030986:pyrimidine