Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk.
OBJECTIVE
To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition.


METHODS
We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.


RESULTS
CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance.


CONCLUSIONS
The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman.
Al-Moundhri
Mansour S
MS
Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Muscat 123, Sultanate of Oman. mansours@squ.edu.om
Al-Khanbashi
Manal
M
Al-Kindi
Mohammed
M
Al-Nabhani
Maryam
M
Burney
Ikram A
IA
Al-Farsi
Abdulaziz
A
Al-Bahrani
Bassim
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009850:Oman; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins