Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.
An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.
Ohno
Osamu
O
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University. ohno@bio.keio.ac.jp
Watabe
Taeko
T
Nakamura
Kazuhiko
K
Kawagoshi
Masaru
M
Uotsu
Nobuo
N
Chiba
Tomohiro
T
Yamada
Masayoshi
M
Yamaguchi
Kohji
K
Yamada
Kaoru
K
Miyamoto
Kenji
K
Uemura
Daisuke
D
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*
D047188:Chalcones; D005419:Flavonoids; D008543:Melanins; D010636:Phenols; D010936:Plant Extracts; C459212:bavachin; C468754:isobavachalcone; C012765:bakuchiol