The ARUBA trial: current status, future hopes.
OBJECTIVE
Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations.


RESULTS
Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial.


CONCLUSIONS
ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.
Mohr
J P
JP
Columbia University College of Physicians and Surgeons, Neurological Institute, New York, NY 10032-2603, USA. jpm10@columbia.edu
Moskowitz
Alan J
AJ
Stapf
Christian
C
Hartmann
Andreas
A
Lord
Karen
K
Marshall
Steven M
SM
Mast
Henning
H
Moquete
Ellen
E
Moy
Claudia Scala
CS
Parides
Michael
M
Pile-Spellman
John
J
Al-Shahi Salman
Rustam
R
Weinberg
Alan
A
Young
William L
WL
Estevez
Alejandrina
A
Kureshi
Inam
I
Brisman
Jonathan L
JL
D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000628:therapy*; D016730:Program Development