title: A case of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma.
abstract: Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. jhcmd@hanyang.ac.kr
authors.forename: Jung-Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Young-Ha
authors.initials: YH
authors.lastname: Oh
authors.forename: Ile-Kyu
authors.initials: IK
authors.lastname: Park