IL-17/il-23 and Chlamydia trachomatis.
Ch. trachomatis is a gram negative bacteria, infecting the most organs of the uro-genital tract and harming greatly the woman's or man's reproductive field. Moreover, as this is not the limit of its destructive nature, it can form a favorable ground for developing ulcer and tumor processes. As observed, a special place is occupied by Ch. trachomatis chronization skill, which is developed irrespective the mighty humoral and cellular respond to its intrusion into the host's organism. It is also known that T (CD4) lymphocytes and their products - cytokines are directly involved into these processes. IL-17 and its regulator IL-23 are among them. For the significance of the above-mentioned processes for expiring the chlamydiosis immune-pathogenesis we have studied the problem in the patients with IL-17 and IL-23 chlamydiosis. We have investigated 56 chlamydia infected patients; 31 non-infected patients who were the carriers of a different pathology flora and 21 healthy donors. The investigation covered some impaired localities as well as the organism overall. To gain the objective we analyzed clinical -anamnesis data and carried out the appropriate instrumental, laboratorial and immunological researches. Stating the chlamydia infection was carried on with the serological and immunofluorescentical and PCR methods. The study of IL-17 and IL-23 is done by ELISA and RT-PCR methods.The findings after the statistical analyses makes us drive to the following conclusions: IL-17 occurs in almost all the patients infected with chlamydia - their organs or systemic environment compared with the patients of non-chlamydia infection (97% against 21%, P<0,05). At the same time, IL-17 has been measured by higher parameters, than IL-23. The highest parameters of IL-17 were recorded with the patients having acute chlamydiosis in the impaired localities and also with the patients having arthritis and high antiovarial antibodies, IL-23 in high digits was recorded with the patients having a high bent to metaplasy. The gained data point the opinion that Il-17 and IL-23 take part in Chlamydia Immune-pathogenesis.
Shavlakadze
N
N
Medical Centre XXI Century, A. Tsereteli State University, Kutaisi, Georgia.
Gorgoshidze
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D015551:Autoimmunity / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology*; D002690:Chlamydia Infections / Q000097:blood / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D053759:Interleukin-23 / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010053:Ovary / Q000276:immunology; D013094:Spermatozoa / Q000276:immunology; D015044:Zona Pellucida / Q000276:immunology
D020381:Interleukin-17; D053759:Interleukin-23