title: Biofunctionalization of titanium implants with a biomimetic active peptide (P-15) promotes early osseointegration.
abstract: OBJECTIVE
  The early stages of peri-implant bone formation play an essential role in the osseointegration and long-term success of dental implants. By incorporating bioactive coatings, this biofunctionalization of implant surfaces may enhance the attachment of the implant to the surrounding bone and stimulate bone regeneration.
  
  
  METHODS
  To demonstrate faster osseointegration, the surfaces of dental implants were grit-blasted and acid-etched. They were then coated with hydroxyapatite (HA) and experimental implants were further coated with a biomimetic active peptide (P-15) in one of two concentrations. These biofunctionalized samples and controls with no peptide were placed in the forehead region of 12 adult pigs. Six animals were evaluated for a period of 14 or 30 days.
  
  
  RESULTS
  Histomorphometric analysis demonstrated that the implants with the high concentration of P-15 had significantly higher percentage of bone-to-implant contact (BIC) at 14 (P=0.018) and 30 (P=0.015) days compared with the other groups. Both concentrations of P-15 showed increased peri-implant bone density compared to the control group at 30 days.
  
  
  CONCLUSIONS
  Biofunctionalization of the implant surface with a biomimetic active peptide leads to significantly increased BIC rates at 14 and 30 days and higher peri-implant bone density at 30 days.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Erlangen, Germany. rainer.lutz@uk-erlangen.de
authors.forename: R
authors.initials: R
authors.lastname: Lutz
authors.forename: S
authors.initials: S
authors.lastname: Srour
authors.forename: J
authors.initials: J
authors.lastname: Nonhoff
authors.forename: T
authors.initials: T
authors.lastname: Weisel
authors.forename: C J
authors.initials: CJ
authors.lastname: Damien
authors.forename: K A
authors.initials: KA
authors.lastname: Schlegel
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis; D002448:Cell Adhesion / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004305:Dose-Response Relationship, Drug; D005624:Frontal Bone / Q000601:surgery; D008852:Microradiography; D016348:Osseointegration / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D013499:Surface Properties; D034421:Sus scrofa; D014025:Titanium
chemical_list: D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen; D014025:Titanium