Stereoselective ring contraction of 2,5-diketopiperazines: An innovative approach to the synthesis of promising bioactive 5-membered scaffolds.
Ring contraction of 2,5-diketopiperazines by TRAL-alkylation led us to the stereoselective synthesis of original pyrrolidine-2,4-diones, a novel series of promising molecules with moderate anti-proliferative activity on breast cancer cells.
Coursindel
Thibault
T
Institut des Biomolécules Max Mousseron, UMR CNRS-Université Montpellier, France.
Restouin
Audrey
A
Dewynter
Georges
G
Martinez
Jean
J
Collette
Yves
Y
Parrot
Isabelle
I
D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D049109:Cell Proliferation / Q000187:drug effects; D054659:Diketopiperazines / Q000138:chemical synthesis / Q000737:chemistry*; D005260:Female; D006801:Humans; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D054659:Diketopiperazines; D011759:Pyrrolidines