title: Polyunsaturated fatty acids and reduced odds of MCI: the Mayo Clinic Study of Aging.
abstract: Mono- and polyunsaturated fatty acids (MUFA, PUFA) have been associated with a reduced risk of dementia. The association of these fatty acids with mild cognitive impairment (MCI) is not fully established. The objective of the study was to investigate the cross-sectional association of dietary fatty acids with MCI in a population-based sample. Participants aged >or= 70 years on October 1, 2004, were evaluated using the Clinical Dementia Rating Scale (participant and informant), a neurological evaluation, and neuropsychological testing. A panel of nurses, physicians, and neuropsychologists reviewed the data for each participant in order to establish a diagnosis of MCI, normal cognition, or dementia by consensus. Participants also completed a 128-item food-frequency questionnaire. Among 1,233 non-demented subjects, 163 (13.2%) had MCI. The odds ratio (OR) of MCI decreased with increasing PUFA and MUFA intake. Compared to the lowest tertile, the OR (95% confidence interval) for the upper tertiles were 0.44 (0.29-0.66; p for trend = 0.0004) for total PUFA; 0.44 (0.30-0.67; p for trend = 0.0004) for omega-6 fatty acids; 0.62 (0.42-0.91; p for trend = 0.012) for omega-3 fatty acids; and 0.56 (0.38-0.83; p for trend = 0.01) for (MUFA+PUFA):saturated fatty acid ratio after adjustment for age, sex, number of years of education, and caloric intake. In this study, higher intake of PUFA and MUFA was associated with a reduced likelihood of MCI among elderly persons in the population-based setting.
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA. roberts.rosebud@mayo.edu
authors.forename: Rosebud O
authors.initials: RO
authors.lastname: Roberts
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Cha
authors.forename: Teresa J H
authors.initials: TJ
authors.lastname: Christianson
authors.forename: V Shane
authors.initials: VS
authors.lastname: Pankratz
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ivnik
authors.forename: Helen M
authors.initials: HM
authors.lastname: O'Connor
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D003072:Cognition Disorders / Q000097:blood*; D004034:Diet Surveys; D004041:Dietary Fats / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage* / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D016017:Odds Ratio; D012044:Regression Analysis; D011795:Surveys and Questionnaires
chemical_list: D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated