title: Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs.
abstract: Therapeutic gene transfer holds promise as a way to treat dilated cardiomyopathy from any underlying cause because the approach attempts to address metabolic disturbances that occur at the molecular level of the failing heart. Calcium-handling abnormalities and increased rates of apoptosis are abnormalities that occur in many types of heart disease, and gene therapies that target these metabolic defects have proven to be beneficial in numerous rodent models of heart disease. The authors are currently evaluating this approach to treat canine idiopathic dilated cardiomyopathy.
authors.affiliation: Department of Clinical Studies, University of Pennsylvania Veterinary School, Philadelphia, PA 19104, USA. sleeper@vet.upenn.edu
authors.forename: Meg M
authors.initials: MM
authors.lastname: Sleeper
authors.forename: Lawrence T
authors.initials: LT
authors.lastname: Bish
authors.forename: H Lee
authors.initials: HL
authors.lastname: Sweeney
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D018014:Gene Transfer Techniques / Q000662:veterinary*; D015316:Genetic Therapy / Q000662:veterinary*; D008297:Male
chemical_list: D002118:Calcium