title: [Cervical Castleman disease in childhood: a report of two cases and a review of the literature].
abstract: Castleman disease (CD) is a benign lymphoproliferative disorder, rare in children. Head and neck localizations are found only in 14 % of the cases. Two forms have been described: a hyaline vascular type and a plasma cell type. It can also be monocentric or multicentric. Both young patients were affected with an isolated neck localization of Castleman disease. Preoperative diagnosis can be difficult with a thymoma or a lymphoma. CT and MRI can help in the diagnosis, which is confirmed by histopathological assessment. The pathological features and the therapeutic management of CD are discussed. While surgery is the treatment for localized lesions, steroids and chemotherapy are indicated in the multicentric type. Because of the risk of relapse and malignant transformation, long-term follow-up is mandatory.
authors.affiliation: UMPC Univ Paris 6, Inserm U-587, Service d'oto-rhino-laryngologie et de chirurgie cervicofaciale, hôpital d'Enfants-Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France. nicolas.leboulanger@trs.aphp.fr
authors.forename: N
authors.initials: N
authors.lastname: Leboulanger
authors.forename: A
authors.initials: A
authors.lastname: Coulomb L'hermine
authors.forename: N
authors.initials: N
authors.lastname: Teissier
authors.forename: I
authors.initials: I
authors.lastname: Rouillon
authors.forename: S
authors.initials: S
authors.lastname: Zribi
authors.forename: G
authors.initials: G
authors.lastname: Roger
authors.forename: E N
authors.initials: EN
authors.lastname: Garabedian
mesh_terms: D000293:Adolescent; D005871:Castleman Disease / Q000145:classification / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy