[Percutaneous verterbreplasty combined with radiotherapy treating malignant vertebrate metastasis].
OBJECTIVE
To evaluate retrospectively the treatment effects and side effects of malignant vertebrate metastasis who had received radiotherapy or percutaneous verterbreplasty (PVP) or PVP combined with radiotherapy.


METHODS
Two hundred and sixty-three patients who had been diagnosed as malignant tumor with vertebrate metastasis received PVP (87 patients) or radiotherapy (111 patients) or PVP combined with radiotherapy (65 patients). Radiotherapy was done one week after PVP procedure in PVP combined with radiotherapy group. All patients received regular follow-up. The changes of pain scale were analyzed by NRS. The improvement of quality of life was evaluated by inquiry questionnaire of EORTC QLQ-C30. The side effects were also observed.


RESULTS
All defects in vertebrate metastasis in PVP treating were fully filled by polymethylmethacrylate (PMMA) under CT examination. The NRS number decreased significantly after 6 hours after treating in PVP Group and PVP combined with radiotherapy Group (P < 0.01), which shows basement of pain was rapid. The NRS number decreased significantly after one month after treating in radiotherapy Group (P < 0.01), which shows basement of pain was slow. The score of EORTC QLQ-C30 inquiry questionnaire in three Groups reduced, which indicated that the quality of life had been improved. In PVP Group and PVP combined with radiotherapy Group, the score of EORTC QLQ-C30 changed most significantly (P < 0.01). There were no severe clinical complications.


CONCLUSIONS
It is safe and effective to treat malignant tumor patients with vertebrate metastasis by PVP combined with radiotherapy and quality of life had been improved significantly with long catabasis.
Xing
Wen-ge
WG
Department of Interventional Therapy, Key Laboratory for Breast Cancer Prevention and Treatment, Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Guo
Zhi
Z
Wang
Jun
J
Liu
Fang
F
Li
Bao-guo
BG
Guo
Xiu-ying
XY
Yu
Hai-peng
HP
Xing
Ji-zhong
JZ
D000328:Adult; D000368:Aged; D001178:Arthroplasty; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D016896:Treatment Outcome