title: Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
abstract: We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
authors.affiliation: Population Genomics, deCODE Genetics, Reykjavik, Iceland. solveig.gretarsdottir@decode.is
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mesh_terms: D000483:Alleles; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000235:genetics* / Q000401:mortality; D001483:Base Sequence; D004198:Disease Susceptibility / Q000150:complications; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D007055:Iceland; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics; D009426:Netherlands; D016017:Odds Ratio; D012307:Risk Factors; D020703:ras GTPase-Activating Proteins
chemical_list: C462952:DAB2IP protein, human; D020703:ras GTPase-Activating Proteins