title: Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit.
abstract: Amino acids are Nature's combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the variety of substituted biomimetic molecules available to successfully implement the Distributed Drug Discovery (D3) project. In a single solid-phase sequence, compatible with basic amine substituents, three-point variation is performed at the amino acid a-carbon and the amino and carboxyl functionalities.
authors.affiliation: Department of Chemistry and Chemical Biology, Indiana University-Purdue University, Indianapolis, 402 N. Blackford Street, Indianapolis, IN 46202, USA. wscott@iupui.edu
authors.forename: William L
authors.initials: WL
authors.lastname: Scott
authors.forename: Ziniu
authors.initials: Z
authors.lastname: Zhou
authors.forename: Paweł
authors.initials: P
authors.lastname: Zajdel
authors.forename: Maciej
authors.initials: M
authors.lastname: Pawłowski
authors.forename: Martin J
authors.initials: MJ
authors.lastname: O'Donnell
mesh_terms: D020650:Combinatorial Chemistry Techniques; D055808:Drug Discovery; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D019151:Peptide Library; D010455:Peptides