title: Depth-resolved blood oxygen saturation assessment using spectroscopic common-path Fourier domain optical coherence tomography.
abstract: Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two issues that could significantly improve the quantitative assessment of blood oxygen saturation level. First, we have implemented a spectral normalization technique to eliminate the spectral modulation induced by the wavelength-distance-dependent point spread function (PSF) of OCT's. Second, to reduce the spectral speckle noise due to the highly scattering blood, we have implemented a spatial low-pass filter to the 2-D OCT dataset consisting of spectra obtained at different lateral positions. We have assessed the effectiveness of these methods using common-path OCT system. Results showed that we were able to extract unambiguous depth-resolved, SO(2)-dependent spectroscopic information from 1-D and 2-D OCT images, which could be used to accurately assess the SO(2) level.
authors.affiliation: Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. xliu35@jhu.edu
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Jin U
authors.initials: JU
authors.lastname: Kang
mesh_terms: D000042:Absorption; D000818:Animals; D005583:Fourier Analysis; D006454:Hemoglobins / Q000032:analysis*; D016011:Normal Distribution; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis*; D012756:Sheep; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen