Synthesis and preliminary evaluation of the antimicrobial activity of selected 3-benzofurancarboxylic acid derivatives.
Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. (1)H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts. Three compounds, III, IV, and VI, showed antimicrobial activity against Gram-positive bacteria (MIC 50 to 200 microg/mL). Compounds VI and III exhibited antifungal activity against the Candida strains C. albicans and C. parapsilosis (MIC-100 microg/mL).
Kossakowski
Jerzy
J
Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland. jerzy.kossakowski@wum.edu.pl
Krawiecka
Mariola
M
Kuran
Bozena
B
Stefańska
Joanna
J
Wolska
Irena
I
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D054879:Halogenation; D008826:Microbial Sensitivity Tests
C510597:3-benzo(b)furan carboxylic acid; D000890:Anti-Infective Agents; D001572:Benzofurans; D002264:Carboxylic Acids