title: proTF: a comprehensive data and phylogenomics resource for prokaryotic transcription factors.
abstract: Investigation of transcription factors (TFs) is of extreme significance for gleaning more information about the mechanisms underlying the dynamic transcriptional regulatory network. Herein, proTF is constructed to serve as a comprehensive data resource and phylogenomics analysis platform for prokaryotic TFs. It has many prominent characteristics: (i) detailed annotation information, including basic sequence features, domain organization, sequence homolog and sequence composition, was extensively collected, and then visually displayed for each TF entry in all prokaryotic genomes; (ii) workset was employed as the basic frame to provide an efficient way to organize the retrieved data and save intermediate records; and (iii) a number of elaborated tools for phylogenomics analysis were implemented to investigate the evolutionary roles of specific TFs. In conclusion, proTF dedicates to the prokaryotic TFs with integrated multi-function, which will become a valuable resource for prokaryotic transcriptional regulatory network in the post-genomic era.
  
  
  BACKGROUND
  http://centre.bioinformatics.zj.cn/proTF.
authors.affiliation: Institute of Genomic Medicine/Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Junrong
authors.initials: J
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.forename: Jingsong
authors.initials: J
authors.lastname: Li
authors.forename: Lijing
authors.initials: L
authors.lastname: Bu
authors.forename: Junming
authors.initials: J
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Bao
authors.forename: Guoping
authors.initials: G
authors.lastname: Zhao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.forename: Jinyu
authors.initials: J
authors.lastname: Wu
mesh_terms: D019843:Archaeal Proteins / Q000737:chemistry* / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D030541:Databases, Genetic; D016678:Genome; D023281:Genomics / Q000379:methods*; D020407:Internet; D010802:Phylogeny; D012984:Software; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D014157:Transcription Factors