title: A cross-sectional hospital-based study of autoantibody profile and clinical manifestations of systemic lupus erythematosus in south Indian patients.
abstract: Our study was aimed to analyze clinical manifestations, autoantibodies and other serological abnormalities in South Indian patients with systemic lupus erythematosus. Clinical history and findings on systemic examination were noted. Antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) were detected by immunofluorescence and ANA profile by Immunoblotting. Arthritis was most common followed by fever and skin rash. Clinical manifestations vary according to geographical location of the patient. ANA was positive in 64.28% and anti-dsDNA in 89.36% of patients. All patients with lupus nephritis were positive for dsDNA. Detection of antibodies to dsDNA, RNP and anti-Smith (Sm) are of diagnostic and prognostic importance.
authors.affiliation: Kasturba Medical College, Light House Hill Road, Mangalore, Manipal University 575 001, India.
authors.forename: K
authors.initials: K
authors.lastname: Kosaraju
authors.forename: S
authors.initials: S
authors.lastname: Shenoy
authors.forename: U
authors.initials: U
authors.lastname: Suchithra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001168:Arthritis / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D005076:Exanthema / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D005455:Fluorescent Antibody Technique; D006761:Hospitals; D006801:Humans; D015151:Immunoblotting; D007194:India; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies