Contribution of residual renal function on peritoneal solute transport in dialysis patients.
BACKGROUND
Increased peritoneal solute transport rate (PSTR) is primarily a consequence of continuous exposure to bioincompatible glucose-based peritoneal dialysis (PD) solutions. However, relationships between increasing PSTR and dialysate glucose load remain unclear. As some PD patients with preserved residual renal function do not show increased PSTR despite long-term PD, we examined whether loss of residual renal function is associated with increased PSTR on long-term PD.


METHODS
We evaluated 35 patients who started PD between 1997 and 2002 and received continuous PD treatment for >6 years. Data included baseline clinical data, residual renal function, urea and creatinine clearance, dialysate glucose load, ultrafiltration, and the use of icodextrin and renin-angiotensin system inhibitors. Peritoneal equilibration test results and data were collected annually for 6 years.


RESULTS
Both the glomerular filtration rate and urine volume at 6 years on PD showed significant negative correlations with the dialysate-to-plasma creatinine ratio (D/P Cr) at 6 years (r = -0.716 and r = -0.717, respectively). Multivariate analysis showed only urine volume at 6 years on PD as an independent covariate of the D/P Cr at 6 years on PD.


CONCLUSIONS
Loss of residual renal function is directly associated with increased PSTR in patients on long-term PD.
Matsuda
Akihiko
A
Matsumura
Osamu
O
Ogawa
Tomonari
T
Tayama
Yousuke
Y
Motojima
Mizuki
M
Maeda
Tadaaki
T
Noiri
Chie
C
Kanouzawa
Kouichi
K
Katou
Hitoshi
H
Hasegawa
Hajime
H
Mitarai
Tetsuya
T
D000328:Adult; D001692:Biological Transport; D003404:Creatinine / Q000378:metabolism*; D015314:Dialysis Solutions / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D012189:Retrospective Studies; D014556:Urine
D015314:Dialysis Solutions; D003404:Creatinine