title: Wound infection after colostomy closure for imperforate anus in children: utility of preoperative oral antibiotics.
abstract: OBJECTIVE
  There is little published data on the efficacy of surgical infection prophylaxis in children. The purpose of this study was to assess wound infection rate in children undergoing colostomy closure for imperforate anus and evaluate the impact of bowel preparation and antibiotics.
  
  
  METHODS
  Children younger than 18 years with imperforate anus who had a colostomy closure between January 1996 and December 2007 were identified. Data collected included demographics, bowel preparation, antibiotics, operative details, and postoperative infections. Comparison of mechanical bowel preparation and intravenous antibiotics with and without oral antibiotics was compared using chi(2) tests. Significance was defined as P < .05.
  
  
  RESULTS
  A total of 118 patients were identified. Primary skin closure was done in 97%. Mechanical bowel preparation was used in 93%, intravenous antibiotics in 97%, and oral preoperative antibiotics in 52%. Wound infections occurred in 14% (n = 17). The addition of oral antibiotics to the standard regimen of mechanical bowel preparation with intravenous antibiotics did not alter infection rate (13% versus 17%, P = .64).
  
  
  CONCLUSIONS
  Wound infection in children undergoing elective colostomy closure for imperforate anus was 14%. Infection rate was not affected by use of oral antibiotics. Future studies may allow specific guideline development for infection prophylaxis in pediatric patients.
authors.affiliation: Division of Pediatric Surgery, Riley Hospital for Children, Indianapolis, IN 46202, USA.
authors.forename: Francine D
authors.initials: FD
authors.lastname: Breckler
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Rescorla
authors.forename: Deborah F
authors.initials: DF
authors.lastname: Billmire
mesh_terms: D000284:Administration, Oral; D019072:Antibiotic Prophylaxis / Q000379:methods; D001006:Anus, Imperforate / Q000601:surgery*; D003125:Colostomy / Q000009:adverse effects* / Q000379:methods; D004573:Electrolytes; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D011092:Polyethylene Glycols; D011300:Preoperative Care; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D004573:Electrolytes; C033608:Golytely; D011092:Polyethylene Glycols