Primary ciliary dyskinesia that responded to long-term, low-dose clarithromycin.
A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls. Otitis media and decreased spermatic motor ability were identified. In addition, electron microscopy of a biopsy specimen of the nasal mucosa showed a deficiency of inner dynein. Based on these clinical findings, primary ciliary dyskinesia (PCD) was diagnosed and successfully treated with long-term, low-dose clarithromycin. Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD.
Yoshioka
Daisuke
D
The Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Sakamoto
Noriho
N
Ishimatsu
Yuji
Y
Kakugawa
Tomoyuki
T
Ishii
Hiroshi
H
Mukae
Hiroshi
H
Kadota
Jun-Ichi
J
Kohno
Shigeru
S
D017291:Clarithromycin / Q000008:administration & dosage*; D006801:Humans; D007619:Kartagener Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
D017291:Clarithromycin