title: Social relationships and mortality risk: a meta-analytic review.
abstract: BACKGROUND
  The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality.
  
  
  OBJECTIVE
  This meta-analytic review was conducted to determine the extent to which social relationships influence risk for mortality, which aspects of social relationships are most highly predictive, and which factors may moderate the risk.
  
  
  METHODS
  Data were extracted on several participant characteristics, including cause of mortality, initial health status, and pre-existing health conditions, as well as on study characteristics, including length of follow-up and type of assessment of social relationships.
  
  
  RESULTS
  Across 148 studies (308,849 participants), the random effects weighted average effect size was OR = 1.50 (95% CI 1.42 to 1.59), indicating a 50% increased likelihood of survival for participants with stronger social relationships. This finding remained consistent across age, sex, initial health status, cause of death, and follow-up period. Significant differences were found across the type of social measurement evaluated (p<0.001); the association was strongest for complex measures of social integration (OR = 1.91; 95% CI 1.63 to 2.23) and lowest for binary indicators of residential status (living alone versus with others) (OR = 1.19; 95% CI 0.99 to 1.44).
  
  
  CONCLUSIONS
  The influence of social relationships on risk for mortality is comparable with well-established risk factors for mortality. Please see later in the article for the Editors' Summary.
authors.affiliation: Department of Psychology, Brigham Young University, Provo, Utah, United States of America. julianne_holt-lunstad@byu.edu
authors.forename: Julianne
authors.initials: J
authors.lastname: Holt-Lunstad
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Smith
authors.forename: J Bradley
authors.initials: JB
authors.lastname: Layton
mesh_terms: D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D006801:Humans; D007398:Interpersonal Relations; D009026:Mortality; D009369:Neoplasms / Q000401:mortality; D012306:Risk; D012944:Social Support