title: Stereological investigation of age-related changes of the capillaries in white matter.
abstract: We, for the first time, investigated the age-related changes of the capillaries in white matter using immunohistochemistry and stereological techniques. Ten young female (7 months) and 10 aged female (27 months) rats were used. The total length, total volume, and total surface area of the capillaries in white matter of aged rats were all significantly lower than those of young rats. The age-related changes of the capillaries in white matter may have important implications for age-related white matter atrophy and age-related cognitive impairments.
authors.affiliation: Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Shao
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Xuan
authors.initials: X
authors.lastname: Qiu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Xia
authors.forename: Ji-Ming
authors.initials: JM
authors.lastname: Kong
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000375:Aging; D000818:Animals; D001284:Atrophy; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply* / Q000473:pathology; D002196:Capillaries / Q000033:anatomy & histology*; D003072:Cognition Disorders / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D051381:Rats; D020318:Rats, Long-Evans