title: Increased sequence conservation of domain repeats in prokaryotic proteins.
abstract: Protein domain repeats within a protein sequence have been observed throughout all domains of life. Our analysis shows a significantly higher degree of sequence identity between repeated domains in prokaryotes compared to eukaryotes. We discuss this difference in the light of aggregation prevention, contribution to functional divergence and binding-related functions. We then address the possible underlying features that create and conserve domain repeats. Our findings provide a starting point for the identification of the fundamental principles that underlie this basic difference between eukaryotic and prokaryotic protein evolution.
authors.affiliation: Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University of Jerusalem, Israel.
authors.forename: Dan
authors.initials: D
authors.lastname: Reshef
authors.forename: Zohar
authors.initials: Z
authors.lastname: Itzhaki
authors.forename: Ora
authors.initials: O
authors.lastname: Schueler-Furman
mesh_terms: D001483:Base Sequence; D017124:Conserved Sequence; D011387:Prokaryotic Cells / Q000737:chemistry* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D011506:Proteins