title: Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.
abstract: Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
authors.affiliation: Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain.
authors.forename: Ma Jesús
authors.initials: MJ
authors.lastname: Pérez de Vega
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: García-López
authors.forename: Laura
authors.initials: L
authors.lastname: Zaccaro
authors.forename: Miriam
authors.initials: M
authors.lastname: Royo
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Asia
authors.initials: A
authors.lastname: Fernández-Carvajal
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferrer-Montiel
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
mesh_terms: D000473:Alkanes; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D019791:Guanidine; D008239:Lysine; D013329:Structure-Activity Relationship; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors*; D014364:Tryptophan
chemical_list: D000473:Alkanes; D004151:Dipeptides; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D014364:Tryptophan; D019791:Guanidine; D008239:Lysine