Endometrial expression of relaxin and relaxin receptor in endometriosis.
Our studies demonstrate significantly lower expression of relaxin and its receptor in ectopic endometriotic tissues than their expression in eutopic endometrium and in endometrium from normal controls. These data suggest that in normal and eutopic endometrium, relaxin may exert a protective effect against endometriosis.
Morelli
Sara S
SS
Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. morellsa@umdnj.edu
Petraglia
Felice
F
Weiss
Gerson
G
Luisi
Stefano
S
Florio
Pasquale
P
Wojtczuk
Andrea
A
Goldsmith
Laura T
LT
D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D008597:Menstrual Cycle / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D010049:Ovarian Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D018000:Receptors, Peptide / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D012065:Relaxin / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D055815:Young Adult
C417543:RXFP1 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; D012065:Relaxin