title: A linear exponent AR(1) family of correlation structures.
abstract: In repeated measures settings, modeling the correlation pattern of the data can be immensely important for proper analyses. Accurate inference requires proper choice of the correlation model. Optimal efficiency of the estimation procedure demands a parsimonious parameterization of the correlation structure, with sufficient sensitivity to detect the range of correlation patterns that may occur. Many repeated measures settings have within-subject correlation decreasing exponentially in time or space. Among the variety of correlation patterns available for this context, the continuous-time first-order autoregressive correlation structure, denoted AR(1), sees the most utilization. Despite its wide use, the AR(1) structure often poorly gauges within-subject correlations that decay at a slower or faster rate than required by the AR(1) model. To address this deficiency we propose a two-parameter generalization of the continuous-time AR(1) model, termed the linear exponent autoregressive (LEAR) correlation structure, which accommodates much slower and much faster decay patterns. Special cases of the LEAR family include the AR(1), compound symmetry, and first-order moving average correlation structures. Excellent analytic, numerical, and statistical properties help make the LEAR structure a valuable addition to the suite of parsimonious correlation models for repeated measures data. Both medical imaging data concerning neonate neurological development and longitudinal data concerning diet and hypertension [DASH (Dietary Approaches to Stop Hypertension) study] exemplify the utility of the LEAR correlation structure.
authors.affiliation: Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1063, USA. slsimpso@wfubmc.edu
authors.forename: Sean L
authors.initials: SL
authors.lastname: Simpson
authors.forename: Lloyd J
authors.initials: LJ
authors.lastname: Edwards
authors.forename: Keith E
authors.initials: KE
authors.lastname: Muller
authors.forename: Pranab K
authors.initials: PK
authors.lastname: Sen
authors.forename: Martin A
authors.initials: MA
authors.lastname: Styner
mesh_terms: D016880:Anisotropy; D018660:Blood Pressure Monitoring, Ambulatory; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004032:Diet; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007231:Infant, Newborn; D007965:Leukodystrophy, Globoid Cell / Q000503:physiopathology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D015233:Models, Statistical; D009186:Myelin Sheath / Q000502:physiology*; D055815:Young Adult