title: Challenges associated with regeneration of orbital floor bone.
abstract: Orbital floor fractures are a serious consequence of craniofacial trauma and account for &#x223C;60%-70% of all orbital fractures. Unfortunately, the body's natural response to orbital floor defects generally may not restore proper function and facial aesthetics, which is complicated by the thin bone and adjacent sinuses. Current clinical treatments include alloplastic implants and autologous grafts; however, each has associated disadvantages and sequelae. This review has outlined necessary components for a successful tissue-engineered construct for orbital floor repair. In addition, current successes and progress in the literature specific to orbital floors and craniofacial research have been reviewed. Finally, challenges and future directions have been described.
authors.affiliation: Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: Martha W
authors.initials: MW
authors.lastname: Betz
authors.forename: John F
authors.initials: JF
authors.lastname: Caccamese
authors.forename: Domenick P
authors.initials: DP
authors.lastname: Coletti
authors.forename: John J
authors.initials: JJ
authors.lastname: Sauk
authors.forename: John P
authors.initials: JP
authors.lastname: Fisher
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D006801:Humans; D009917:Orbital Fractures / Q000601:surgery*; D019736:Prostheses and Implants; D023822:Tissue Engineering; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials