title: The C19-diterpenoid alkaloids.
abstract: The diterpenoid alkaloids, with an intriguing chemistry and numerous varied bioactivities, constitute the largest and most complicated group of terpenoid alkaloids. Among them, the C19-diterpenoid alkaloids have attracted extensive and lasting attention from researchers. This chapter with 1075 references systematically summarizes the past 30 years of studies on the C19-diterpenoid alkaloids, covering the classification and distribution, biogenesis and biosynthesis, applications in the phytochemotaxonomy of Chinese Aconitum L., spectral properties (1H and 13C NMR, MS), X-ray crystallographic analysis, chemical reactions and chemical conversions (as a continuation of Volume 42 of this treatise), and pharmacological activity of this important group of alkaloids. This review on the C19-diterpenoid alkaloids, in combination with two previous reviews in this treatise (C20-diterpenoid alkaloids, Volume 59, and C18-diterpenoid alkaloids, Volume 67), will present readers with a complete and updated profile of the diterpenoid alkaloids. The only exception is the description of the total syntheses of the diterpenoid alkaloids, which will be summarized in a subsequent individual chapter.
authors.affiliation: Department of Chemistry of Medicinal Natural Products, West China of Pharmacy, Sichuan University, Chengdu, People's Republic of China. wfp@scu.edu.cn
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Wang
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Chen
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D004365:Drugs, Chinese Herbal