The effect of pulpotomy using a calcium-enriched mixture cement versus one-visit root canal therapy on postoperative pain relief in irreversible pulpitis: a randomized clinical trial.
The purpose of this noninferiority trial was to compare postoperative pain relief after one-visit root canal therapy (ORCT) with a pulpotomy performed with a new endodontic calcium-enriched mixture cement (PCEM) in human permanent molars with irreversible pulpitis. A total of 407 selected patients were randomly allocated into the ORCT group (n = 202) or the PCEM group (n = 205). Numerical Rating Scale questionnaires were used to record pain intensity (PI) by the patients during the first 7 days after treatment. While there was no statistically significant difference in the mean PI at baseline between the two study groups (P = 0.45), changes in mean PI were significantly different between them (P < 0.001). In the ORCT group, pain relief was achieved after 36 h [95% confidence interval (CI), 27.00-45.00], compared to 18 h in the PCEM group (95% CI, 15.00-21.00), a significant difference (P < 0.01). Comparison of the mean PI sum recorded over 7 days showed that patients in the ORCT group experienced significantly more pain than those in the PCEM group (P < 0.001); a similar difference was observed for pain in response to percussion tests (P < 0.001). Treatment with PCEM thus had the better pain-reducing effects than ORCT in irreversible pulpitis cases.
Asgary
Saeed
S
Iranian Center for Endodontic Research, Dental Research Center, Dental School, Shahid Beheshti Medical University, Evin, Tehran, 1983963113, Iran. saasgary@yahoo.com
Eghbal
Mohammad Jafar
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use*; D002133:Calcium Sulfate / Q000627:therapeutic use; D002648:Child; D003738:Dental Cements / Q000627:therapeutic use*; D004853:Epoxy Resins / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006171:Gutta-Percha / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008963:Molar / Q000473:pathology; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011145:Polyvinyls / Q000627:therapeutic use; D011671:Pulpitis / Q000628:therapy*; D011672:Pulpotomy / Q000379:methods*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012390:Root Canal Therapy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult; D015034:Zinc Oxide / Q000627:therapeutic use
D000700:Analgesics; D003738:Dental Cements; D004853:Epoxy Resins; D011145:Polyvinyls; D012387:Root Canal Filling Materials; C534916:epoxy resin-based root canal sealer; C020872:Cavit; D006171:Gutta-Percha; D015034:Zinc Oxide; D002118:Calcium; D002133:Calcium Sulfate