title: Geraniinic acid derivative from the leaves of Phyllanthus reticulatus.
abstract: Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl-5-[2',3',4'-trihydroxy-6'-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3'-tri-O-methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC(50) value of 27.27 microg/mL.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 73000.
authors.forename: Nuch
authors.initials: N
authors.lastname: Pojchaijongdee
authors.forename: Uthai
authors.initials: U
authors.lastname: Sotanaphun
authors.forename: Siripan
authors.initials: S
authors.lastname: Limsirichaikul
authors.forename: Onoomar
authors.initials: O
authors.lastname: Poobrasert
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018411:Spodoptera
chemical_list: C553911:4,6-dimethoxycarbonyl-5-(2',3',4'-trihydroxy-6'-(methoxycarbonyl)phenyl)-5,6-dihydro-2H-pyran-2-one; D007306:Insecticides; D010936:Plant Extracts; D011753:Pyrones; D005707:Gallic Acid