title: Autoantibodies in patients with Alzheimer's disease: pathogenetic role and potential use as biomarkers of disease progression.
abstract: Growing evidence suggests that autoantibodies specific to distinct molecular antigens are present in sera or cerebrospinal fluids from patients with Alzheimer's disease (AD). They could have a protective (i.e., anti-β-amyloid) or a pathogenetic role (i.e., anti-GM1 or anti-ATP synthase) but, in any case, they might be considered as useful diagnostic or prognostic markers of the disease. In this review, we briefly summarize the autoantibodies known to be detectable in patients with AD and we discuss their potential role in the pathogenesis of the disease, as well as their potential use as peripheral blood biomarkers.
authors.affiliation: Istituto San Raffaele Sulmona, Italy.
authors.forename: Tania
authors.initials: T
authors.lastname: Colasanti
authors.forename: Cristiana
authors.initials: C
authors.lastname: Barbati
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rosano
authors.forename: Walter
authors.initials: W
authors.lastname: Malorni
authors.forename: Elena
authors.initials: E
authors.lastname: Ortona
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D003704:Dementia; D018450:Disease Progression; D006801:Humans
chemical_list: D001323:Autoantibodies; D015415:Biomarkers