Exosomes in erythropoiesis.
Multivesicular endosomes contain membrane vesicles which can be released into the extracellular environment as exosomes. This review describes the role of exosome secretion in the remodeling of the red cell plasma membrane during the last stage of erythropoietic differentiation. Herein, we propose that the exosome biogenesis involves several mechanisms of protein sorting and leads to partial or complete loss of membrane activities, in some cases in a regulated way.
Vidal
M
M
UMR 5235 CNRS (DIMNP), université Montpellier II - cc 107, place E.-Bataillon, 34095 Montpellier cedex 05, France. mvidal@univ-montp2.fr
D000818:Animals; D002454:Cell Differentiation; D004705:Endocytosis / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology; D011992:Endosomes / Q000502:physiology; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology; D004920:Erythropoiesis / Q000502:physiology*; D055354:Exosomes / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D008565:Membrane Proteins / Q000097:blood; D012156:Reticulocytes / Q000502:physiology*; D015398:Signal Transduction
D008565:Membrane Proteins