title: The impact of the extent of lymph-node dissection on biochemical relapse after radical prostatectomy in node-negative patients.
abstract: BACKGROUND
  The therapeutic role of pelvic lymph-node dissection (PLND) for prostate cancer (PCa) is still unclear. The aim of this study was to assess the impact of the number of lymph nodes (LN) retrieved at PLND during radical prostatectomy (RP) on biochemical relapse (BCR) in node-negative patients.
  
  
  METHODS
  From October 1995 to June 2009, 1510 consecutive PCa patients underwent RP at the University of Bologna hospital. A retrospective analysis was performed on 614 pT2-4N0 patients with a minimum follow-up of 12 months. All 614 patients underwent limited or extended PLND during RP. BCR-free survival was estimated using the Kaplan-Meier method. Cox regression was applied to analyse survivals rates. Patients were divided into two groups: group 1 (n=295) had 1 to 9 retrieved LNs and group 2 (n=319) had 10 or more retrieved. The parameters analysed were age, PSA, clinical and pathological Gleason score (GS), stage, margin status and adjuvant radiotherapy (ART). BCR was defined as PSA greater than 0.2 ng/ml.
  
  
  RESULTS
  Mean follow-up time was 62.5+/-39.7 months. Group 2 showed a significantly lower BCR than group 1 (p=0.019). LN group, PSA, clinical and pathological GS, pathological stage and ART all showed an independent and significant relationship with BCR using multivariate analysis.
  
  
  CONCLUSIONS
  In node-negative patients, a more extensive PLND affects BCR-free survival positively. A more extensive PLND may have a therapeutic role by removal of micrometastases.
authors.affiliation: Department of Urology, University of Bologna, S. Orsola-Malpighi Hospital, Palagi 9, 40134, Bologna, Italy. rschiavina@yahoo.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Schiavina
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bertaccini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Franceschelli
authors.forename: Fabio
authors.initials: F
authors.lastname: Manferrari
authors.forename: Valerio
authors.initials: V
authors.lastname: Vagnoni
authors.forename: Marco
authors.initials: M
authors.lastname: Borghesi
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Morselli-Labate
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Martorana
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D017430:Prostate-Specific Antigen