title: [Localization diagnosis of carcinoma in situ of bladder cancer by pirarubicin: preliminary clinical experience].
abstract: OBJECTIVE
  To investigate whether the location of carcinoma in situ (CIS) of bladder cancer could be macroscopically ascertained by instilling pirarubicin (THP) into urinary bladder.
  
  
  METHODS
  50 mg of THP was dissolved into 50 ml of 5% glucose solution. And the resulting solution was instilled into urinary bladder. After 15 min, the urinary bladder was observed by a cystoscopy. The study group consisted of 51 patients with bladder cancer (37 males, 14 females) and 14 patients with hematuria (8 males, 6 females), treated at our hospital from December 2007 to June 2008.
  
  
  RESULTS
  The THP uptake was seen in 67 flat (non-tumorous) areas of bladder mucosa in 37 patients with bladder cancer. Of these, 11 lesions in 7 patients were confirmed to be CIS. The THP uptake was found in 2 flat (non-tumorous) areas of bladder mucosa in 14 patients with hematuria, 1 lesion in 1 patient was confirmed to be CIS. The sensitivity and specificity of THP uptake by CIS were 92.3% (12/13) and 86.7% (371/428) respectively.
  
  
  CONCLUSIONS
  This practical method may be employed to ascertain easily the macroscopic location of CIS of bladder cancer.
authors.affiliation: Department of Urology, First People's Hospital, Affiliated to Shanghai Jiaotong University, Institute of Urological Research, Shanghai Jiaotong University, Shanghai, China. xsjurologist@163.com
authors.forename: Shu-jie
authors.initials: SJ
authors.lastname: Xia
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Song
authors.initials: S
authors.lastname: Xue
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Sun
authors.forename: Bang-min
authors.initials: BM
authors.lastname: Han
authors.forename: Yi-yong
authors.initials: YY
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhuo
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis*; D004317:Doxorubicin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
chemical_list: D004317:Doxorubicin; C027260:pirarubicin