Luminescent conjugates between dinuclear rhenium(I) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting.
New luminescent dinuclear rhenium(I) tricarbonyl complex-PNA conjugates have been synthesized through a reliable solid-phase synthetic methodology. Their photophysical properties have been measured. The most luminescent Re-PNA conjugate 7 showed interesting two-photon absorption (TPA) properties, that were exploited for imaging experiments, to demonstrate its easy uptake into living cells.
Ferri
Elena
E
Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, via Venezian 21, I-20133 Milano, Italy.
Donghi
Daniela
D
Panigati
Monica
M
Prencipe
Giuseppe
G
D'Alfonso
Laura
L
Zanoni
Ivan
I
Baldoli
Clara
C
Maiorana
Stefano
S
D'Alfonso
Giuseppe
G
Licandro
Emanuela
E
D002460:Cell Line; D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D049449:Luminescence; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000032:analysis* / Q000737:chemistry*; D012211:Rhenium / Q000032:analysis* / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; D020135:Peptide Nucleic Acids; D012211:Rhenium; D004247:DNA