Elevated plasma levels of apelin in children with type 1 diabetes mellitus.
BACKGROUND
Apelin is a novel adipocytokine produced by white adipose tissue that binds the APJ receptor with high affinity. Insulin may have a role in regulation of apelin synthesis and secretion from the adipose tissue.


OBJECTIVE
To investigate blood apelin concentrations in children with type 1 diabetes mellitus (T1DM) and display association of apelin with adiponectin, body mass index (BMI), lipids and insulin sensitivity.


METHODS
Thirty patients with T1DM and 45 healthy controls were enrolled. Apelin levels were measured along with BMI, lipids, fasting plasma glucose, HbA1c and adiponectin levels.


RESULTS
Plasma apelin and adiponectin levels were significantly higher in the diabetic group when compared to controls. No correlation was found between the apelin blood concentrations and adiponectin, BMI, lipids and insulin sensitivity.


CONCLUSIONS
Children with T1DM have significantly increased circulating apelin levels when compared to healthy controls. However, no significant relation was found between the apelin and BMI, glucose, lipids and adiponectin levels, and also insulin sensitivity.
Meral
Cihan
C
Department of Paediatrics, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. drcihanm@yahoo.com
Tascilar
Emre
E
Karademir
Ferhan
F
Tanju
Ilhan Asya
IA
Cekmez
Ferhat
F
Ipcioglu
Osman Metin
OM
Ercin
Cemal Nuri
CN
Gocmen
Ismail
I
Dogru
Teoman
T
D052242:Adiponectin / Q000097:blood; D000073861:Apelin; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005508:Food Deprivation; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008024:Ligands; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male
D052242:Adiponectin; D000073861:Apelin; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D008055:Lipids; C115436:APLN protein, human; C517652:hemoglobin A1c protein, human