Increased ERCC1 protein expression is associated with suboptimal debulking in advanced epithelial ovarian cancer.
Some biological features, such as amount of ascites and molecular tissue markers, have been found to correlate with debulking outcome in advanced epithelial ovarian cancer (EOC). This study investigated whether proteins involved in nucleotide excision repair of EOC affected the debulking outcome.


METHODS
The relationship between dichotomised clinical characteristics, ERCC1 and XPD protein expression levels in 78 patients were tested by univariate and multivariate analysis to determine the independent significance of factors for debulking outcome. Receiver operating characteristic (ROC) curves were constructed to determine their predictive value.


RESULTS
Pre- and postoperative CA125, ascites, menopause, and ERCC1 protein all significantly correlated with debulking outcome. However, only ERCC1 was the only independent factor, with the area under the ROC curve being 0.724.


CONCLUSIONS
ERCC1 protein is an independent prognostic indicator for debulking outcome in advanced EOC.
Lin
Feili
F
Department of Internal Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310006, People's Republic of China.
Lin
Kaiqing
K
Xie
Xing
X
Zhou
Caiyun
C
D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D004268:DNA-Binding Proteins / Q000032:analysis / Q000502:physiology*; D004720:Endonucleases / Q000032:analysis / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000601:surgery*
D018394:CA-125 Antigen; D004268:DNA-Binding Proteins; C071447:ERCC1 protein, human; D004720:Endonucleases