title: Ultrastructural diversity of inclusions and aggregations in the lumbar spinal cord of SOD1-G93A transgenic mice.
abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. We report the characteristics of ultrastructural pathological changes of inclusions and aggregations in the neuronal axons, glial cells and ventral roots of lumbar spinal cord in SOD1-G93A transgenic mice using light and electron transmission microscope at different stages of disease. The most noteworthy is that mutant SOD1 accumulations in the cytoplasm of motor neurons precede the numerous inclusions. Inclusions manifested differently according to the specified locations. This study provided further information to the previous reports about pathological changes of ALS.
authors.affiliation: Department of Neurology, The Second Hospital of Hebei Medical University, Hebei 050000, China.
authors.forename: Yansu
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.forename: Dongxia
authors.initials: D
authors.lastname: Wu
authors.forename: Shuyu
authors.initials: S
authors.lastname: Wu
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongran
authors.initials: H
authors.lastname: Wu
authors.forename: Zhongyao
authors.initials: Z
authors.lastname: Li
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000473:pathology*; D000818:Animals; D001253:Astrocytes / Q000473:pathology / Q000648:ultrastructure; D004195:Disease Models, Animal; D006801:Humans; D008161:Lumbosacral Region / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D046529:Microscopy, Electron, Transmission / Q000379:methods; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D013116:Spinal Cord / Q000473:pathology* / Q000648:ultrastructure*; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: C109415:SOD1 G93A protein; D013482:Superoxide Dismutase