title: A multi-case report of acute renal failure in patients treated with Aggrenox.
abstract: BACKGROUND
  Aggrenox is used in the secondary prevention of stroke. Acute renal failure, potentially associated with Aggrenox, has been observed in several patients.
  
  
  OBJECTIVE
  The objective of this study was to determine if Aggrenox was associated with acute renal failure and to determine whether it was acetylsalicylic acid, dipyridamole or the combination that led to decline in renal function.
  
  
  METHODS
  A case series of three patients suffering severe nausea, vomiting, diarrhea, renal dysfunction and clinical decline during Aggrenox therapy was examined. Serum creatinine and Blood Urea Nitrogen (BUN) were measured to evaluate renal function.
  
  
  RESULTS
  Analysis of this patient group revealed that Patient 1 experienced nausea, emesis, anorexia, diarrhea and significant clinical decline during treatment with Aggrenox. Patients 2 and 3 also presented with complaints of nausea and emesis. Lab measurements along with clinical symptoms indicated that all three patients experienced acute renal failure, having increases in serum creatinine of 186%, 144% and 249%, respectively. Symptoms and lab work returned to baseline following discontinuation of Aggrenox.
  
  
  CONCLUSIONS
  It is biologically plausible that Aggrenox may contribute to renal dysfunction in patients under certain pathophysiological circumstances.
authors.affiliation: St. Joseph's Care Group, Thunder Bay, Ontario, Canada. joyk@tbh.net
authors.forename: Kerry
authors.initials: K
authors.lastname: Joy
authors.forename: Sacha
authors.initials: S
authors.lastname: Dubois
authors.forename: Carrie
authors.initials: C
authors.lastname: Gibbons
authors.forename: John
authors.initials: J
authors.lastname: Hargadon
authors.forename: Michel
authors.initials: M
authors.lastname: Bédard
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*; D001241:Aspirin / Q000009:adverse effects*; D000068342:Aspirin, Dipyridamole Drug Combination; D003404:Creatinine / Q000097:blood; D004176:Dipyridamole / Q000009:adverse effects*; D004338:Drug Combinations; D006801:Humans
chemical_list: D000068342:Aspirin, Dipyridamole Drug Combination; D004338:Drug Combinations; D004176:Dipyridamole; D003404:Creatinine; D001241:Aspirin