title: Human non-CG methylation: are human stem cells plant-like?
abstract: Non-CG methylation is well characterized in plants, where it appears to play a role in gene silencing and genomic imprinting. Although strong evidence for the presence of non-CG methylation in animals has been available for some time, both its origin and function remain elusive. In this review we discuss available evidence on non-CG methylation in animals in light of evidence suggesting that the human stem cell methylome contains significant levels of methylation outside the CG site.
authors.affiliation: Pushchino Branch, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Dyachenko
authors.forename: Tara V
authors.initials: TV
authors.lastname: Schevchuk
authors.forename: Leo
authors.initials: L
authors.lastname: Kretzner
authors.forename: Yaroslav I
authors.initials: YI
authors.lastname: Buryanov
authors.forename: Steven S
authors.initials: SS
authors.lastname: Smith
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000378:metabolism; D018744:DNA, Plant / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010944:Plants / Q000235:genetics* / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D018744:DNA, Plant; D015254:DNA Modification Methylases