Beta3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects.
We determined whether ADRbeta3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).
Genelhu
V A
VA
Laboratório de Fisiopatologia Clínica e Experimental (CLINEX), Clínica de Hipertensão, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Francischetti
E A
EA
Duarte
S F P
SF
Celoria
B M J
BM
Oliveira
R C
RC
Cabello
P H
PH
Pimentel
M M G
MM
D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics; D001938:Brazil; D002318:Cardiovascular Diseases / Q000150:complications* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
D022702:Receptors, Adrenergic, beta-3