title: [S-1-based chemotherapy for recurrent gastric cancer with peritoneal dissemination resulting in long-term survival--report of a case].
abstract: A 52-year-old man underwent distal gastrectomy for gastric cancer in July 2000. In July 2005, abdominal CT and barium study of the colon revealed peritoneal recurrence, and chemotherapy of S-1 was started. Within 2 courses, the serum CEA level increased, so combination chemotherapy of S-1 and cisplatin (CDDP) was begun. After 7 courses, the regimen was switched to S-1+paclitaxel (PTX). However, the patient developed digital numbness within 8 courses and single-agent chemotherapy with S-1 was restarted. In July 2007, he developed abdominal distension, and abdominal CT showed a large amount of ascites. S-1+CDDP was administered again, however, and we had to change the regimen within 3 courses due to fatigue and appetite loss. S-1 was restarted, but soon severe fatigue and appetite loss restricted the use of chemotherapeutic agents, and he died in December. This patient had been alive for 2 years and 5 months since peritoneal recurrence was diagnosed. We concluded that S-1-based sequential chemotherapy was effective for recurrent gastric cancer.
authors.affiliation: Department of Surgery, Yodogawa Christian Hospital.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Wakahara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Toyokawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Tomono
authors.forename: Soichiro
authors.initials: S
authors.lastname: Tani
authors.forename: Taku
authors.initials: T
authors.lastname: Yamamichi
authors.forename: Narutomo
authors.initials: N
authors.lastname: Nishioka
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Gon
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamashita
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Kanemitsu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Okuda
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hamabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004338:Drug Combinations; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D012008:Recurrence; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid