[A study on the targeting collect character of ferromagnetic drug carrier particles in microvasculature].
The transport and capture of therapeutic magnetic particles in the human microvasculature is studied numerically. Taking into account the dominant magnetic and fluidic forces on the particles, we have shown in our study that the particles can be directed to and concentrated at the desired zone which is within a few centimeters from the surface of the body. In addition, we have analyzed the influences of the malignant tissue depth, of the nanometers-iron nuclide content in a particle, and of the blood flow velocity and blood vessel diameter upon the captured efficiency.
Li
Xinxia
X
School of Nuclear Science and Technology, University of South China, Hengyang 421001, China. leexinxia@163.com
Guo
Ping
P
Chen
You
Y
Xiong
Ping
P
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001692:Biological Transport; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D059346:Magnets / Q000737:chemistry*; D055806:Microvessels / Q000378:metabolism*; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy; D010316:Particle Size
D000970:Antineoplastic Agents; D004337:Drug Carriers