Cathepsins and their involvement in immune responses.
The immune system is composed of an enormous variety of cells and molecules that generate a collective and coordinated response on exposure to foreign antigens, called the immune response. Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases.
Conus
Sébastien
S
Institute of Pharmacology, University of Bern, Bern, Switzerland. sebastien.conus@pki.unibe.ch
Simon
Hans-Uwe
HU
D056704:Adaptive Immunity / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D017209:Apoptosis / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001249:Asthma / Q000276:immunology; D050197:Atherosclerosis / Q000276:immunology; D002403:Cathepsins / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D053804:Granzymes / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology*; D007121:Immunocompetence / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D008247:Lysosomes / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D010003:Osteoarthritis / Q000276:immunology; D010447:Peptide Hydrolases / Q000502:physiology
D016207:Cytokines; D002403:Cathepsins; D010447:Peptide Hydrolases; D053804:Granzymes