title: Serum levels of adiponectin and leptin in children born small for gestational age: relation to insulin sensitivity parameters.
abstract: Children born small for gestational age (SGA) are prone to developing obesity, insulin resistance and type 2 diabetes. Adiponectin and leptin are adipocytokines associated with insulin sensitivity parameters. We aimed to relate serum adiponectin and leptin levels with insulin sensitivity parameters in prepuberal SGA children with and without catch-up growth (SGA+CUG; SGA-CUG, respectively) and to analyze the usefulness of these adipocytokines as early markers of insulin resistance. We analysed adiponectin, proinsulin, leptin, growth factors, insulin, HOMA IR and HOMA beta(cell) in 23 SGA+CUG, 26 SGA-CUG children compared with 48 prepuberal appropiate for gestational age (AGA). SGA children had adiponectin levels comparable to AGA children. Leptin levels were different between sexes, showed to be higher in SGA+CUG group (p=0.040) and these were significantly correlated with insulin sensitivity parameters. These results suggest leptin resistance as an adaptive mechanism to increase energy balance, but an altered functional response of adipocytes cannot be discarded.
authors.affiliation: Servicio de Endocrinologia, Hospital de Niños de la Santisima Trinidad, Córdoba, Argentina.
authors.forename: Mirta
authors.initials: M
authors.lastname: Miras
authors.forename: Mariana
authors.initials: M
authors.lastname: Ochetti
authors.forename: Silvia
authors.initials: S
authors.lastname: Martín
authors.forename: Liliana
authors.initials: L
authors.lastname: Silvano
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sobrero
authors.forename: Laura
authors.initials: L
authors.lastname: Castro
authors.forename: Mariana
authors.initials: M
authors.lastname: Onassis
authors.forename: Nori
authors.initials: N
authors.lastname: Tolosa de Talamoni
authors.forename: Adriana
authors.initials: A
authors.lastname: Pérez
authors.forename: Gabriela
authors.initials: G
authors.lastname: Picotto
authors.forename: Gabriela
authors.initials: G
authors.lastname: Díaz de Barboza
authors.forename: Liliana
authors.initials: L
authors.lastname: Muñoz
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005260:Female; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood* / Q000254:growth & development; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D011384:Proinsulin / Q000097:blood; D011627:Puberty / Q000097:blood* / Q000502:physiology
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011384:Proinsulin