Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation.
The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.
Guo
Dadong
D
State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, 210096, Nanjing, China. xuewang@seu.edu.cn.
Wu
Chunhui
C
Li
Jingyuan
J
Guo
Airong
A
Li
Qingning
Q
Jiang
Hui
H
Chen
Baoan
B
Wang
Xuemei
X