No bones about it: insulin modulates skeletal remodeling.
Advancing the hypothesis that bone remodeling is intimately linked to metabolic homeostasis, Fulzele et al. (2010) and Ferron et al. (2010) present evidence that insulin signaling promotes the activation of bone-forming osteoblasts and enhances production of osteocalcin, a secreted mediator of insulin sensitivity, through modulation of bone resorption.
Rosen
Clifford J
CJ
Maine Medical Center Research Institute, Scarborough, ME 04074, USA. rosenc@mmc.org
Motyl
Katherine J
KJ