title: Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane.
abstract: OBJECTIVE
  To investigate the health effects of 1-bromopropane (1-BP) and its dose-dependency in 1-BP production factories in China.
  
  
  METHODS
  Data of 60 female and 26 male workers in three 1-BP factories and the same number of age-, sex-, and region-matched controls were interviewed and examined. The time-weighed average exposure levels of individual workers were estimated.
  
  
  RESULTS
  Regression analysis on exposure level showed dose-dependent increase in the distal latency of tibial nerve, threshold for vibration sense in toes, lactate dehydrogenase, thyroid stimulating hormone, and follicle stimulating hormone in female workers. The analysis also showed dose-dependent decrease in sensory nerve conduction velocity of the sural nerve, red blood cell, and hematocrit in female workers.
  
  
  CONCLUSIONS
  The results indicate that exposure to 1-BP induces dose-dependent neurotoxicity in female workers.
authors.affiliation: School of Public Health/MOE Key Lab for Public Health Safety, Fudan University, Shanghai, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Li
authors.forename: Eiji
authors.initials: E
authors.lastname: Shibata
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhou
authors.forename: Sahoko
authors.initials: S
authors.lastname: Ichihara
authors.forename: Hailan
authors.initials: H
authors.lastname: Wang
authors.forename: Qiangyi
authors.initials: Q
authors.lastname: Wang
authors.forename: Jiefei
authors.initials: J
authors.lastname: Li
authors.forename: Lingyi
authors.initials: L
authors.lastname: Zhang
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Xuncheng
authors.initials: X
authors.lastname: Ding
authors.forename: Gaku
authors.initials: G
authors.lastname: Ichihara
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000009:adverse effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D012678:Sensation Disorders / Q000139:chemically induced*; D012737:Sex Factors; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D006842:Hydrocarbons, Brominated; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D007770:L-Lactate Dehydrogenase; C118559:1-bromopropane