title: Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer.
abstract: BACKGROUND
  The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachytherapy versus patients who received stereotactic body radiotherapy (SBRT) for single malignant lung nodules.
  
  
  METHODS
  A retrospective chart review included 55 patients who were treated for single lung nodules, and 47 of those patients who had adequate information were chosen for the current analysis. Twenty-five patients with single malignant lung nodules received SBRT. Twenty-two patients underwent limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules.
  
  
  RESULTS
  Univariate statistical analysis demonstrated a significance difference only for age in the 2 groups: The mean age in the radioactive seed group (66.6 years) was statistically significantly different from the mean of the age in the SBRT group (75.9 years; 2-sided P=.04). No significant differences were observed between the 2 groups in terms of local control, distant metastasis, survival, or toxicity.
  
  
  CONCLUSIONS
  The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and SBRT for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy.
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York 10021, USA. bup9001@med.cornell.edu
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Parashar
authors.forename: Priti
authors.initials: P
authors.lastname: Patel
authors.forename: Stefano
authors.initials: S
authors.lastname: Monni
authors.forename: Prabhsimranjot
authors.initials: P
authors.lastname: Singh
authors.forename: Nikki
authors.initials: N
authors.lastname: Sood
authors.forename: Samuel
authors.initials: S
authors.lastname: Trichter
authors.forename: Albert
authors.initials: A
authors.lastname: Sabbas
authors.forename: A Gabriella
authors.initials: AG
authors.lastname: Wernicke
authors.forename: Dattatreyudu
authors.initials: D
authors.lastname: Nori
authors.forename: K S Clifford
authors.initials: KS
authors.lastname: Chao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*