Evaluation of antirotavirus activity of flavonoids.
Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure-activity relationships (SAR) were proposed based on antirotavirus activity.
Savi
Luciane Anita
LA
Laboratório de Virologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC 88.040-970, Brazil.
Caon
Thiago
T
de Oliveira
Ana Paula
AP
Sobottka
Andrea Michel
AM
Werner
Wolfgang
W
Reginatto
Flávio Henrique
FH
Schenkel
Eloir Paulo
EP
Barardi
Célia Regina Monte
CR
Simões
Cláudia Maria Oliveira
CM
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012401:Rotavirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D005419:Flavonoids