title: Pre-operative intravenous dexamethasone prevents auditory threshold shift in a guinea pig model of cochlear implantation.
abstract: OBJECTIVE
  To protect hearing during cochlear implantation with systemic administration of dexamethasone.
  
  
  METHODS
  Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2-32 kHz) were estimated between pre- and 4-week-postoperative levels.
  
  
  RESULTS
  ABR threshold shifts (8-32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group.
  
  
  CONCLUSIONS
  A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.
authors.affiliation: Department of Otolaryngology, University of Melbourne, East Melbourne, Vic., Australia.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Connolly
authors.forename: Hayden
authors.initials: H
authors.lastname: Eastwood
authors.forename: Gordana
authors.initials: G
authors.lastname: Kel
authors.forename: Halina
authors.initials: H
authors.lastname: Lisnichuk
authors.forename: Rachael
authors.initials: R
authors.lastname: Richardson
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Leary
mesh_terms: D000818:Animals; D019929:Cochlear Implantation; D003907:Dexamethasone / Q000494:pharmacology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006309:Hearing / Q000187:drug effects* / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone