title: Genome-wide association studies of cancer: principles and potential utility.
abstract: Genome-wide association studies (GWAS) have emerged as a new approach for investigating the genetic basis of complex diseases. In oncology, genome-wide studies of nearly all common malignancies have been performed and more than 100 genetic variants associated with increased risks have been identified. GWAS approaches are powerful research tools that are revealing novel pathways important in carcinogenesis and promise to further enhance our understanding of the basis of inherited cancer susceptibility. However, "personal genomic tests" based on cancer GWAS results that are currently being offered by for-profit commercial companies for cancer risk prediction have unproven clinical utility and may risk false conveyance of reassurance or alarm.
authors.affiliation: Department of Medicine, Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: Zsofia K
authors.initials: ZK
authors.lastname: Stadler
authors.forename: David J
authors.initials: DJ
authors.lastname: Gallagher
authors.forename: Peter
authors.initials: P
authors.lastname: Thom
authors.forename: Kenneth
authors.initials: K
authors.lastname: Offit
mesh_terms: D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors