title: Regulation of alternative splicing by short non-coding nuclear RNAs.
abstract: Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. We review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.
authors.affiliation: University of Kentucky, Molecular and Cellular Biochemistry, South Limestone, Lexington, KY, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Khanna
authors.forename: Stefan
authors.initials: S
authors.lastname: Stamm
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D009841:Oligonucleotides / Q000378:metabolism; D022821:RNA Splice Sites; D058727:RNA, Small Untranslated / Q000378:metabolism*; D017423:Sequence Analysis, RNA
chemical_list: D009841:Oligonucleotides; D022821:RNA Splice Sites; D058727:RNA, Small Untranslated