title: Meniere's disease: update of etiopathogenetic theories and proposal of a possible model of explanation.
abstract: Meniere's Disease (MD) is an affection consisting of an association of sensorineural hearing loss, tinnitus and vertigo initially presenting by crises. A review of the most considered possible causative factors and pathophysiologic interpretations allows us to underline the uncertainties which still exist about the genesis of this illness. We propose a mechanistic model based on the effect of a haemodynamic imbalance leading to transient ischaemia which could have an effect on the pH of the inner ear as well as on the work of the inner ear proton pumps. It is hypothesized that under ischaemic conditions and consequent metabolic acidity a preserved proton pump activity can generate an overload of anions in the endolymphatic partition, which is a closed system, thus resulting in an enhancement of osmolarity and consequently in the formation of a hydrops resulting in the development of fluctuating hearing loss, tinnitus and vertigo which characterize Meniere's Disease.
authors.affiliation: Department of Specialistic Surgical & Anaesthesiological Sciences, ENT Section, S. Orsola Malpighi University Hospital, Bologna, Italy. antonio.pirodda@unibo.it
authors.forename: A
authors.initials: A
authors.lastname: Pirodda
authors.forename: C
authors.initials: C
authors.lastname: Brandolini
authors.forename: M Chiara
authors.initials: MC
authors.lastname: Raimondi
authors.forename: G Gaetano
authors.initials: GG
authors.lastname: Ferri
authors.forename: G C
authors.initials: GC
authors.lastname: Modugno
authors.forename: C
authors.initials: C
authors.lastname: Borghi
mesh_terms: D006801:Humans; D008575:Meniere Disease / Q000209:etiology* / Q000473:pathology*