title: Efficacy of topical cyanoacrylates compared to topical silicone gel in the treatment of hypertrophic scars.
abstract: OBJECTIVE
  The effectiveness of cyanoacrylates compared to silicone gel in improving healing of hypertrophic scars was evaluated.
  
  
  METHODS
  Patients presenting hypertrophic scars 6 to 24 months old were enrolled. Asymmetrical scars were treated with cyanoacrylates, linear scars were divided in two parts, one treated with cyanoacrylates, the other with silicone gel. For 3 months, cyanoacrylates were applied every 3-5 days, silicone gel twice a day. Patients' and external observers' assessments were recorded over one year, and photographic records taken. Objective evaluations included width, length and elevation measurements. Statistical significance of parameter modifications was analysed with the Wilcoxon test.
  
  
  RESULTS
  A total of 150 patients were enrolled. Positive effects of both tested products were observed without major adverse effects, achieving final scars of better quality. Scar elevation was reduced significantly for both tested products, but apparently more for topical cyanoacrylates.
  
  
  CONCLUSIONS
  Cyanoacrylates have a positive effect on pathological scars at least comparable to that of silicone gel.
authors.affiliation: Department of Plastic and Reconstructive Surgery, La Sapienza University of Rome, 00161 Rome, Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Scuderi
authors.forename: Luca Andrea
authors.initials: LA
authors.lastname: Dessy
authors.forename: Marco
authors.initials: M
authors.lastname: Mazzocchi
authors.forename: Stefano
authors.initials: S
authors.lastname: Chiummariello
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Onesti
mesh_terms: D000287:Administration, Topical; D002921:Cicatrix / Q000473:pathology; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy / Q000473:pathology*; D003487:Cyanoacrylates / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D006984:Hypertrophy; D010349:Patient Compliance; D010781:Photography; D020034:Silicone Gels / Q000008:administration & dosage / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D003487:Cyanoacrylates; D020034:Silicone Gels