title: Construction of eight-membered carbocycles with trisubstituted double bonds using the ring closing metathesis reaction.
abstract: Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and our own results are cited and the importance of the preparation of suitably designed precursors is discussed. Examples of RCM reactions used in the total synthesis of natural products are also outlined.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan. tori@ph.bunri-u.ac.jp
authors.forename: Motoo
authors.initials: M
authors.lastname: Tori
authors.forename: Reiko
authors.initials: R
authors.lastname: Mizutani
mesh_terms: D003500:Cyclization; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006844:Hydrocarbons, Cyclic