[Natriuretic peptides as cardiac markers in clinical practice].
Cardiac natriuretic peptides, BNP and NT-proBNP can be used to screen for left ventricular systolic dysfunction in patients with symptoms suggestive of heart failure. Using the cut-off values recommended in the article, the sensitivity and negative predictive values are high in patients aged < 75 years, but have lower sensitivity at older age. In addition, natriuretic peptides are prognostic markers for mortality and cardiovascular hospitalization. BNP/NT-proBNP measurement may also be of value in follow-up on heart failure patients.
Veien
Karsten Tange
KT
Kardiologisk Afdeling, Vejle Sygehus, 7100 Vejle. amtangev@ofir.dk
Jensen
Jesper Khédri
JK
Hildebrandt
Per
P
Gøtze
Jens Peter
JP
Nielsen
Olav Wendelboe
OW
Køber
Lars
L
D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012016:Reference Values; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000175:diagnosis*
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain