title: Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation.
abstract: A novel and highly efficient one-pot three-component synthesis of alpha-aminophosphonates under neat condition was developed. By employing this method, hybrid compounds of aminophosphonate with pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline and dimethyl phosphite. The antiviral and antileishmanial activities of these novel hybrid compounds were also studied but none were found to be active.
authors.affiliation: School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan, P. R. China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qu
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
authors.forename: C
authors.initials: C
authors.lastname: Bores
authors.forename: Dong
authors.initials: D
authors.lastname: Feng
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Loiseau
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D017905:Phosphites / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D063065:Organophosphonates; D017905:Phosphites; D011741:Pyrimidine Nucleosides; C061519:5-formyl-2'-deoxyuridine; C023650:aniline; C047356:dimethyl hydrogen phosphite; D003857:Deoxyuridine