Voluptuary habits and clinical subtypes of Parkinson's disease: the FRAGAMP case-control study.
We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.
Nicoletti
Alessandra
A
Dipartimento di Neuroscienze, Università di Catania, Catania, Italy.
Pugliese
Pierfrancesco
P
Nicoletti
Giuseppe
G
Arabia
Gennarina
G
Annesi
Grazia
G
Mari
Michele De
MD
Lamberti
Paolo
P
Grasso
Lucia
L
Marconi
Roberto
R
Epifanio
Antonio
A
Morgante
Letterio
L
Cozzolino
Autilia
A
Barone
Paolo
P
Torchia
Giusi
G
Quattrone
Aldo
A
Zappia
Mario
M
D000368:Aged; D016022:Case-Control Studies; D003069:Coffee / Q000009:adverse effects; D004326:Drinking; D005260:Female; D006184:Habits; D006801:Humans; D007558:Italy; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000145:classification* / Q000453:epidemiology* / Q000209:etiology / Q000523:psychology*; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects
D003069:Coffee