Synthesis and adrenolytic activity of new propanolamines.
The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenoceptor binding affinity.
Groszek
Grazyna
G
Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Avenue, 35-959 Rzeszów, Poland. ggroszek@prz.edu.pl
Bajek
Agata
A
Bis
Agnieszka
A
Nowak-Król
Agnieszka
A
Bednarski
Marek
M
Siwek
Agata
A
Filipek
Barbara
B
D018674:Adrenergic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D058671:Adrenergic beta-1 Receptor Antagonists; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D004837:Epinephrine / Q000633:toxicity; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011412:Propanolamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats
D018674:Adrenergic Antagonists; D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D058671:Adrenergic beta-1 Receptor Antagonists; D000889:Anti-Arrhythmia Agents; D011412:Propanolamines; D004837:Epinephrine