title: Discontinuation of long-term proton pump inhibitor therapy in primary care patients: a randomized placebo-controlled trial in patients with symptom relapse.
abstract: BACKGROUND
  A significant proportion of patients treated empirically with a proton pump inhibitor (PPI) present with symptoms of functional dyspepsia with a high placebo-response to therapy. It is possible that a subgroup of empirically treated patients redeem repeated prescriptions because of a positive response to therapy despite symptoms that are not acid related.
  
  
  OBJECTIVE
  To study whether discontinuation of long-term PPI therapy is possible in symptomatically treated patients. To investigate the effect of a PPI in patients with symptom relapse without abnormal endoscopic findings.
  
  
  METHODS
  Seventy-eight long-term primary care PPI users without verified indication for therapy discontinued treatment. In case of symptom recurrence, an endoscopy was performed. Patients without abnormal endoscopic findings were randomized to 7 days oesomeprazole 40 mg once daily or placebo.
  
  
  RESULTS
  A total of 11 of 78 (14%) patients discontinued the therapy successfully. Fifty-three of 78 patients (68%) experienced symptom recurrence. Thirty-one of 53 patients (59%) had a normal endoscopy. Successful effect of therapy after 7 days was observed in 12 of 15 patients (80%) in the oesomeprazole group versus two of 16 (13%) in the placebo group (P<0.001).
  
  
  CONCLUSIONS
  Discontinuation of long-term PPI therapy is possible in a minority of primary care patients. Short-term oesomeprazole was superior to placebo in patients with symptom recurrence and a normal endoscopy.
authors.affiliation: Department of Medical Gastroenterology, Køge Hospital, Copenhagen University, Køge, Denmark. mail@christinareimer.dk
authors.forename: Christina
authors.initials: C
authors.lastname: Reimer
authors.forename: Peter
authors.initials: P
authors.lastname: Bytzer
mesh_terms: D000328:Adult; D000368:Aged; D004415:Dyspepsia / Q000188:drug therapy* / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006338:Heart Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage / Q000009:adverse effects*; D010919:Placebos; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*
chemical_list: D010919:Placebos; D054328:Proton Pump Inhibitors; D009853:Omeprazole