Prenatal screening for thrombophilias: indications and controversies.
A thrombophilia is defined as a disorder of hemostasis that predisposes a person to a thrombotic event. Data suggest that at least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia, which can lead to an increased risk of maternal thromboembolism and adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal demise, preterm preeclampsia, and intrauterine growth restriction. Inherited and acquired thrombophilias have different indications for testing. This article examines screening procedures for thrombophilias in the setting of adverse pregnancy outcomes.
Carbone
Jeanine F
JF
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63110, USA. carboneje@wudosis.wustl.edu
Rampersad
Roxane
R
D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000517:prevention & control; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis*; D054556:Venous Thromboembolism / Q000209:etiology* / Q000517:prevention & control