Functional assessments in the rodent stroke model.
Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Motor, sensory and cognitive deficits are common following stroke, yet treatment is limited. Along with histological measures, functional outcome in animal models has provided valuable insight to the biological basis and potential rehabilitation efforts of experimental stroke. Developing and using tests that have the ability to identify behavioral deficits is essential to expanding the development of translational therapies. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in rodent models. While there is no perfect test, there are many assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.
Schaar
Krystal L
KL
University of Texas Medical School at Houston, Department of Neurology, 6431 Fannin Houston, TX 77030, USA. Sean.I.Savitz@uth.tmc.edu.
Brenneman
Miranda M
MM
Savitz
Sean I
SI