Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats.
The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of beta-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
Ahmed
Mohammed Fazil
MF
Department of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, India.
Kazim
Syed Mohammed
SM
Ghori
Syed Safiullah
SS
Mehjabeen
Syeda Sughra
SS
Ahmed
Shaik Rasheed
SR
Ali
Shaik Mehboob
SM
Ibrahim
Mohammed
M