Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats.
Fructose feeding induces a rise in blood pressure in normal rats and is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. We have examined the effect of myricetin (100 and 300 mg/kg, p.o. for 6 weeks) isolated from Vitis vinifera Linn. (Vitaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, and insulin in fructose-induced hypertension. Myricetin reduced systolic blood pressure and vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration-response curve (CCRC) of Ang II was shifted toward the right in rats treated with myricetin, using isolated strips of ascending colon. The results suggest that myricetin could prevent the development of high blood pressure induced by a diet rich in fructose, probably by reversing the metabolic alterations induced by fructose. In conclusion, myricetin has antihypertensive action in the fructose model.
Godse
Sandip
S
Department of Pharmacology, M.G.V.'s Pharmacy College, Panchavati, Nasik, Maharashtra, India.
Mohan
Mahalaxmi
M
Kasture
Veena
V
Kasture
Sanjay
S
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000633:toxicity; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D005632:Fructose / Q000008:administration & dosage / Q000633:toxicity*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D004040:Dietary Carbohydrates; D005419:Flavonoids; D005632:Fructose; C040015:myricetin