[Preliminary study on etiology of Budd-Chiari syndrome through clinic and experiment].
OBJECTIVE
To investigate the etiology of Budd-Chiari syndrome (BCS) preliminarily.


METHODS
The clinical findings of radical surgery of 109 cases with BCS from March 2001 to May 2009 were analyzed. The pathological components of membranous tissue (MT) from inferior vena cava (IVC) or hepatic vein (HV) of BCS patients were compared with that of thrombus from deep venous thrombosis (DVT), as well as the expression of transforming growth factor beta receptor (TGF-beta R), platelet derived growth factor receptor (PDGFR), endothelin (ET-1), factor VIII related antigen (FVIII-rAg), ferritin and alpha1-antitrypsin in MTs and thrombus through immunohistochemical method.


RESULTS
One hundred and four cases of BCS were due to IVC and/or HV membrane or thrombosis except that 4 cases due to IVC tumor or 1 case due to compression of fiber. The new-formed IVC membrane was found in 2 recurred cases whose IVC thrombus was excised before 1 year and 7 years. The development from organized thrombus to MT was found in 3 cases of segmental obstruction of IVC. The IVC membrane located below HV outlet was in 8 cases. Both MTs and thrombus had the pathological components such as fibroblast, neutrophil, granulation tissue, newly-formed blood vessels and so on under the light microscope. The expressions of TGF-beta R, PDGFR, ET-1, FVIII-rAg, and ferritin in MTs and thrombus were as follows: MT 72.3%, thrombus 50.0% (P > 0.05); MT 45.5%, thrombus 100% (P < 0.05); MT 100%, thrombus 0 (P < 0.05); MT 90.9%, thrombus 12.5% (P < 0.05); MT 72.3%, thrombus 100% (P > 0.05).


CONCLUSIONS
The membranous tissues and thrombus have the similar homogeneity and cytokines expression. The membrane and thrombus may be different pathological phases.
Zhang
Xiao-ming
XM
Department of Vascular Surgery, People's Hospital of Peking University, Beijing, China. rmxgwk@yahoo.com.cn
Li
Yan-kui
YK
Shen
Chen-yang
CY
Li
Qing-le
QL
Yuan
Lian
L
Zhao
Ke-Qiang
KQ
Li
Wei
W
Zhang
Xue-min
XM
D000293:Adolescent; D000328:Adult; D000368:Aged; D006502:Budd-Chiari Syndrome / Q000209:etiology* / Q000473:pathology; D002648:Child; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000150:complications; D014682:Vena Cava, Inferior / Q000473:pathology; D055815:Young Adult
D016207:Cytokines