title: Gastroduodenal mucosal injury in patients taking low-dose aspirin and the role of gastric mucoprotective drugs: possible effect of rebamipide.
abstract: The present study was conducted to investigate the prevalence of mucosal injury in patients taking low-dose aspirin in Japan and examine the effect of gastric mucoprotective drugs on aspirin-related gastroduodenal toxicity. We selected 530 patients who had taken low-dose aspirin for 1 month or more after undergoing esophagogastroduodenoscopy from 2005 through 2006 at Teikyo University Hospital, Tokyo, Japan. Endoscopic records were retrospectively reviewed to determine the presence of massive bleeding and mucosal injury (ulcer or erosion). The influence of clinical factors, including co-administration of gastroprotective drugs, was also examined. Hemorrhage was observed in 25 patients (3.7%) and mucosal injury (36.2%) in 192 patients. The presence of Helicobacter pylori antibody was a significant risk factor associated with mucosal injury. Patients taking any gastroprotective drug showed a significantly lower rate of mucosal injury than those not taking these drugs. Patients taking rebamipide concomitantly with proton pump inhibitors or histamine 2 receptor antagonists had mucosal injury less frequently than those taking acid suppressants plus other mucoprotective drugs. In conclusion, these results show the possible gastroprotective effects of rebamipide, suggesting that it may be a good choice in aspirin users with gastroduodenal toxicity that is not suppressed by acid suppressants alone.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Akari
authors.initials: A
authors.lastname: Isono
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mishina
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Ebato
authors.forename: Tsuguru
authors.initials: T
authors.lastname: Shirai
authors.forename: Shin
authors.initials: S
authors.lastname: Nakayama
authors.forename: Kunitaka
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Abe
authors.forename: Kengo
authors.initials: K
authors.lastname: Hattori
authors.forename: Taro
authors.initials: T
authors.lastname: Ishii
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kuyama