title: Hfq regulates anti-oxidative ability in Vibrio parahaemolyticus.
abstract: Hfq plays a fundamental role in bacterial cell physiology. It can stimulate or repress the expression of certain target genes, and there is a possibility that Hfq regulates the oxidative stress response. However, how Hfq functions that in Vibrio parahaemolyticus remains speculative. In this paper, we explain the functions Hfq plays in V. parahaemolyticus in the gene expression of superoxide dismutase gene and catalase gene, comparing the hfq deletion mutant strain to the parental strain. The results show that the hfq deletion mutant V. parahaemolyticus has a stronger ability to resist H(2)O(2). Superoxide dismutase (SOD) and catalase (CAT) activities in the hfq deletion mutant were remarkably higher than in the parental strain. Genetic experiments indicated that the gene expression of sod and kat was up-regulated in the mutant strain. These results indicate that Hfq down-regulates CAT and SOD activity, and Hfq is associated with the oxidative stress response.
authors.affiliation: Department of Preventive Environment and Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho 3-18-15, Tokushima City, Tokushima, Japan.
authors.forename: Zehong
authors.initials: Z
authors.lastname: Su
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakano
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Koga
authors.forename: Xin
authors.initials: X
authors.lastname: Lian
authors.forename: Akiko
authors.initials: A
authors.lastname: Hamamoto
authors.forename: Takaaki
authors.initials: T
authors.lastname: Shimohata
authors.forename: Yumi
authors.initials: Y
authors.lastname: Harada
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mawatari
authors.forename: Nagakatsu
authors.initials: N
authors.lastname: Harada
authors.forename: Masatake
authors.initials: M
authors.lastname: Akutagawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakaya
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
mesh_terms: D002374:Catalase / Q000235:genetics / Q000378:metabolism; D035001:Host Factor 1 Protein / Q000502:physiology*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D014736:Vibrio parahaemolyticus / Q000378:metabolism*
chemical_list: D035001:Host Factor 1 Protein; D002374:Catalase; D013482:Superoxide Dismutase