Genome-wide association studies in Plasmodium species.
Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity. Geographical substructure in populations may, however, prove a problem in interpreting the results.
Penman
Bridget
B
Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Buckee
Caroline
C
Gupta
Sunetra
S
Nee
Sean
S
D055106:Genome-Wide Association Study; D006801:Humans; D008288:Malaria / Q000469:parasitology*; D016780:Malaria, Vivax / Q000469:parasitology; D010961:Plasmodium / Q000235:genetics* / Q000472:pathogenicity; D010966:Plasmodium vivax / Q000235:genetics / Q000472:pathogenicity