title: Chemoprevention of head and neck cancer with green tea polyphenols.
abstract: Recently, squamous cell carcinoma of the head and neck chemoprevention research has made major advances with novel clinical trial designs suited for the purpose, use of biomarkers to identify high-risk patients, and the emergence of numerous molecularly targeted agents and natural dietary compounds. Among many natural compounds, green tea polyphenols, particularly (-)-epigallocatechin-3-gallate (EGCG), possess remarkable potential as chemopreventive agents. EGCG modulates several key molecular signaling pathways at multiple levels and has synergistic or additive effects when combined with many other natural or synthetic compounds. This review will provide an update of the potential of green tea polyphenols, particularly EGCG, for the chemoprevention of squamous cell carcinoma of the head and neck.
authors.affiliation: Emory University, Atlanta, GA 30322, USA. dmshin@emory.edu
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Kim
authors.forename: A R M Ruhul
authors.initials: AR
authors.lastname: Amin
authors.forename: Dong M
authors.initials: DM
authors.lastname: Shin
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D002392:Catechin / Q000031:analogs & derivatives / Q000627:therapeutic use; D018890:Chemoprevention / Q000379:methods; D005419:Flavonoids / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000517:prevention & control*; D006801:Humans; D008954:Models, Biological; D010636:Phenols / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use; D059808:Polyphenols; D013662:Tea / Q000737:chemistry
chemical_list: D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate