title: Ethyl glucuronide concentrations in oral fluid, blood, and urine after volunteers drank 0.5 and 1.0 g/kg doses of ethanol.
abstract: The aim of this study was to investigate the concentrations of ethyl glucuronide (EtG) in oral fluid, blood, and urine after healthy volunteers drank two doses of ethanol, 0.5 (n = 11) and 1.0 g/kg (n = 10), after an overnight fast. Samples of oral fluid, blood, and urine were collected before drinking started and at 1.5, 3.5, 5.5, 8.5, 11.5, and 24 h post-dosing. Following ingestion of low dose of ethanol, the Cmax for EtG was 0.36 mg/L (range 0.28-0.41 mg/L) in blood and 69.8 mg/L (range 47.1-96.5 mg/L) in urine. In oral fluid, the concentrations were < 1% of those in blood, and only three subjects exceeded the limit of quantification for EtG in oral fluid. After ingestion of the high dose of ethanol, the Cmax for EtG was 1.06 mg/L (range 0.8-1.22 mg/L) in blood, 159.9 mg/L (range 97.2-225.5 mg/L) in urine, and 0.032 mg/L (range 0.013-0.059 mg/L) in oral fluid. The median oral fluid/blood ratio was 0.029 (range 0.012-0.054) for EtG. The detection time for EtG was median 11.5 h (range 3.5-11.5 h) in oral fluid. According to this, the detection time for EtG in oral fluid is therefore only a few hours longer than for ethanol itself and represents limited additional value.
authors.affiliation: Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Nydalen, Oslo, Norway. Gudrun.Hoiseth@fhi.no
authors.forename: Gudrun
authors.initials: G
authors.lastname: Høiseth
authors.forename: Borghild
authors.initials: B
authors.lastname: Yttredal
authors.forename: Ritva
authors.initials: R
authors.lastname: Karinen
authors.forename: Hallvard
authors.initials: H
authors.lastname: Gjerde
authors.forename: Jørg
authors.initials: J
authors.lastname: Mørland
authors.forename: Asbjørg
authors.initials: A
authors.lastname: Christophersen
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001835:Body Weight; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D005965:Glucuronates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008297:Male; D012463:Saliva / Q000378:metabolism; D055815:Young Adult
chemical_list: D005965:Glucuronates; C093924:ethyl glucuronide; D000431:Ethanol