title: Three cases of severe ulcerative esophagitis induced by SUTENT®.
abstract: BACKGROUND
  The development of SUTENT® revolutionized the care of metastatic renal carcinoma and of non-operable GIST. The tolerance is quite good with mostly mild side effects grade 1 or 2.
  
  
  METHODS
  We report the case of three severe esophagitis stage 4 responsible for digestive bleeding. Two patients were taking anti-coagulant that could worsen the bleeding, but none were taking either antiplatelet or non-steroidal anti-inflammatory or corticosteroid that could favour erosion or ulceration of the digestive mucosa. It seems that SUTENT® is responsible for the digestive bleeding.
  
  
  CONCLUSIONS
  Cases of esophagitis induced by SUTENT® have already been reported but are rare and of mild severity. Our three cases of esophagitis are severe with SUTENT® treatment as only risk factor and worsened by anti-coagulant treatment for two patients. It might be of interest preventively to treat these patients with inhibitors of proton pump.
authors.affiliation: Department of Oncological Medico-Surgical Explorations, Institut Paoli-Calmettes, Marseille, France. odile.malet@yahoo.fr
authors.forename: Odile
authors.initials: O
authors.lastname: Jeanniard-Malet
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Gravis
authors.forename: Fabrice
authors.initials: F
authors.lastname: Caillol
authors.forename: Christian
authors.initials: C
authors.lastname: Pesenti
authors.forename: Erwan
authors.initials: E
authors.lastname: Bories
authors.forename: Marc
authors.initials: M
authors.lastname: Giovannini
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D004941:Esophagitis / Q000139:chemically induced*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011758:Pyrroles / Q000009:adverse effects*; D000077210:Sunitinib; D014456:Ulcer / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib