title: Frequencies of ETV6-RUNX1 fusion and hyperdiploidy in pediatric acute lymphoblastic leukemia are lower in far east than west.
abstract: BACKGROUND
  Both ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) in transformed lymphoblasts are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).
  
  
  METHODS
  Among 433 Taiwanese children with ALL diagnosed at our hospitals between 1997 and 2007, the ETV6-RUNX1 fusion was found in 15.8%, and hyperdiploidy (>50 chromosomes) in 14.1% of the patients. These frequencies were lower than those reported in the West, leading us to conduct a meta-analysis of ETV6-RUNX1 fusion and hyperdiploidy frequencies in childhood ALL based on published reports.
  
  
  RESULTS
  The frequency of ETV6-RUNX1 fusion in the Far East (Japan, Korea, China, Hong Kong, Chinese in Singapore, and Taiwan) was 13.4% (177/1,321, range: 9-23%, median 13%), significantly lower than the 22.8% (1,664/7,291, range: 19-26%, median 23%) in the West (West Europe and the United States) (P < 0.001, odds ratio = 2.0, 95% CI: 1.7-2.4). Similarly, the frequency of hyperdiploidy in Japan and Taiwan was 14.3% (333/2,334, range: 12-20%, median 16%), significantly lower than the 25.2% in the West (5,173/20,510, range: 18-34%, median 23.5%; P < 0.001, odds ratio = 2.0, 95% CI: 1.8-2.3).
  
  
  CONCLUSIONS
  This meta-analysis demonstrates lower frequencies of ETV6-RUNX1 fusion and hyperdiploidy among leukemia patients in the Far East compared with the West. The integral relationship of these genetic features with a favorable outcome in childhood ALL warrants further study of potentially important epidemiologic factors, including placental exposure to leukemogenic agents, and host pharmacogenetics.
authors.affiliation: Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan. dcliang@ms2.mmh.org.tw
authors.forename: Der-Cherng
authors.initials: DC
authors.lastname: Liang
authors.forename: Lee-Yung
authors.initials: LY
authors.lastname: Shih
authors.forename: Chao-Ping
authors.initials: CP
authors.lastname: Yang
authors.forename: Iou-Jih
authors.initials: IJ
authors.lastname: Hung
authors.forename: Hsi-Che
authors.initials: HC
authors.lastname: Liu
authors.forename: Tang-Her
authors.initials: TH
authors.lastname: Jaing
authors.forename: Ting-Chi
authors.initials: TC
authors.lastname: Yeh
authors.forename: Sung-Tzu
authors.initials: ST
authors.lastname: Liang
authors.forename: Chia-Ling
authors.initials: CL
authors.lastname: Chang
authors.forename: En-Hui
authors.initials: EH
authors.lastname: Lee
authors.forename: Chung Liang
authors.initials: CL
authors.lastname: Lai
authors.forename: Wan-Hui
authors.initials: WH
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D050676:Core Binding Factor Alpha 2 Subunit; D004171:Diploidy; D018572:Disease-Free Survival; D005060:Europe; D005202:Asia, Eastern; D006801:Humans; D007223:Infant; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality; D015996:Survival Rate; D014481:United States; D044465:White People / Q000235:genetics; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein