Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.
Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.
Chianese
Giuseppina
G
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131, Napoli, Italy.
Yerbanga
Serge R
SR
Lucantoni
Leonardo
L
Habluetzel
Annette
A
Basilico
Nicoletta
N
Taramelli
Donatella
D
Fattorusso
Ernesto
E
Taglialatela-Scafati
Orazio
O
D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031601:Azadirachta / Q000737:chemistry*; D002050:Burkina Faso; D005638:Fruit / Q000737:chemistry; D036701:Limonins / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000962:Antimalarials; D036701:Limonins; D014315:Triterpenes; C487479:azadirone; C552230:neemfruitin A; C552231:neemfruitin B; C106014:gedunin