Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes.
In women with endometriosis, including those with endometriomas, 6 to 8 weeks of continuous use of oral contraception (OC) before assisted reproduction treatment (ART) maintains ART outcomes comparable with the outcomes of age-matched controls without endometriosis. In contrast, ART outcomes are markedly compromised in endometriosis patients who are not pretreated with OC. Ovarian responsiveness to stimulation was not altered by 6 to 8 weeks' use of pre-ART OC, including in poor responders with endometriomas.
de Ziegler
Dominique
D
Department of Obstetrics, Gynecology, and Reproductive Medicine, Université Paris Descartes-Assistance Publique Hôpitaux de Paris, CHU Cochin, Paris, France. ddeziegler@orange.fr
Gayet
Vanessa
V
Aubriot
François Xavier
FX
Fauque
Patricia
P
Streuli
Isabelle
I
Wolf
Jean Philippe
JP
de Mouzon
Jacques
J
Chapron
Charles
C
D000328:Adult; D003131:Combined Modality Therapy; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004715:Endometriosis / Q000150:complications / Q000628:therapy*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011379:Prognosis; D027724:Reproductive Techniques, Assisted; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000008:administration & dosage; D014591:Uterine Diseases / Q000150:complications / Q000628:therapy*
D003276:Contraceptives, Oral; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone