title: Pyodermatitis-pyostomatitis vegetans after subtotal colectomy for ulcerative colitis.
abstract: A 51-year-old Japanese woman underwent subtotal colectomy for ulcerative colitis 5 years before her first visit to our hospital, and her symptoms stabilized. She presented with a 2-month history of proliferative, pustular lesions on her face, scalp, and gingival and anal mucosae. Histological examination showed features similar to those of pemphigus vegetans. However, the results of immunofluorescence studies, immunoblot analysis and enzyme-linked immunosorbent assay for pemphigus were negative, and colonoscopy revealed a relapse of ulcerative colitis in the remaining rectal mucosa, so a diagnosis of pyodermatitis-pyostomatitis vegetans was made. This is the first report of mucocutaneous lesions that developed with a relapse of ulcerative colitis in the remaining rectum after subtotal colectomy. Moreover, a close correlation was found between the condition of bowel inflammation and that of mucocutaneous lesions.
authors.affiliation: Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. asuka-k@kanazawa-med.ac.jp
authors.forename: Asuka
authors.initials: A
authors.lastname: Kitayama
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Misago
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Iwakiri
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Narisawa
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D016572:Cyclosporine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011711:Pyoderma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence; D013280:Stomatitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D019804:Mesalamine; D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine