IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy.
We report a patient with anti-myelin-associated glycoprotein (MAG) neuropathy, predominantly exhibiting severe motor symptoms, accompanied by extensive muscle atrophy mimicking Charcot-Marie-Tooth disease. Nerve conduction studies revealed mild retardation of motor conduction velocities and significant prolongation of distal latency. Sural nerve biopsy revealed widely spaced myelin and positive staining of myelinated fibers with an IgM antibody. Predominant motor symptoms with muscle atrophy can be one of the clinical manifestations of anti-MAG neuropathy.
Kawagashira
Yuichi
Y
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kondo
Naohide
N
Atsuta
Naoki
N
Iijima
Masahiro
M
Koike
Haruki
H
Katsuno
Masahisa
M
Tanaka
Fumiaki
F
Kusunoki
Susumu
S
Sobue
Gen
G
D002607:Charcot-Marie-Tooth Disease / Q000473:pathology; D003937:Diagnosis, Differential; D004568:Electrodiagnosis; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D035002:Lower Extremity / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D009431:Neural Conduction / Q000502:physiology; D010265:Paraproteinemias / Q000473:pathology* / Q000628:therapy
D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D018992:Myelin-Associated Glycoprotein