title: pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies.
abstract: We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification. This case raises the question of the presence and the evolution of this genotype in Africa, which is also known to alter the susceptibility to artemisinin combination therapy (ACT).
authors.affiliation: Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, Toulouse, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Witkowski
authors.forename: Xavier
authors.initials: X
authors.lastname: Iriart
authors.forename: Patrice Njomnang
authors.initials: PN
authors.lastname: Soh
authors.forename: Sandie
authors.initials: S
authors.lastname: Menard
authors.forename: Muriel
authors.initials: M
authors.lastname: Alvarez
authors.forename: Veronique
authors.initials: V
authors.lastname: Naneix-Laroche
authors.forename: Bruno
authors.initials: B
authors.lastname: Marchou
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Magnaval
authors.forename: Françoise
authors.initials: F
authors.lastname: Benoit-Vical
authors.forename: Antoine
authors.initials: A
authors.lastname: Berry
mesh_terms: D000328:Adult; D000354:Africa, Western; D037621:Artemisinins / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination / Q000379:methods; D018628:Gene Dosage; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology*; D008297:Male; D015767:Mefloquine / Q000494:pharmacology / Q000627:therapeutic use*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D017211:Treatment Failure
chemical_list: D037621:Artemisinins; D015767:Mefloquine; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C513498:Mdr1 protein, Plasmodium falciparum; C031327:artemisinin