DNA-based nanostructures for molecular sensing.
Nanotechnology has opened up new avenues towards ultra-sensitive, highly selective detection of biological molecules and toxic agents, as well as for therapeutic targeting and screening. Though the goals may seem singular, there is no universal method to identify or detect a molecular target. Each system is application-specific and must not only identify the target, but also transduce this interaction into a meaningful signal rapidly, reliably, and inexpensively. This review focuses on the current capabilities and future directions of DNA-based nanostructures in sensing and detection.
Lee
Jong Bum
JB
Department of Biological & Environmental Engineering, Cornell University, 226 Riley Robb, Ithaca, New York 14853, USA.
Campolongo
Michael John
MJ
Kahn
Jason Samuel
JS
Roh
Young Hoon
YH
Hartman
Mark Richard
MR
Luo
Dan
D
D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D021881:DNA, Catalytic; D004337:Drug Carriers; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*
D021881:DNA, Catalytic; D004337:Drug Carriers; D004798:Enzymes; D004247:DNA