Evaluation of Bauhinia monandra aqueous and ethanol extracts in pregnant rats.
Bauhinia monandra Kurz. (Fabaceae: Caesalpinioideae) is a plant widely employed in Brazilian folk medicine for hypoglycemia. However, little is known about the effect of maternal exposure to this plant on fetal development. The aqueous and ethanol extracts obtained from B. monandra dried leaves were administered to pregnant Wistar rats throughout gestation (day 1 to day 20) at 1,400 or 7,000 mg/kg/day (n = 6/group). Maternal toxicity was not observed in the dams of both groups, and was evaluated by observing body weight, water and food intake during treatment, by measuring serum biochemical levels of creatinine, urea, AST and ALT, and by studying the histopathology of liver, kidney, pancreas, spleen and uterus at the end of treatment (gestation day 20). Both extracts and doses did not impair reproductive performance or delay fetal development, measured by observing implantations and reabsorptions in the uterus, by counting the number of corpora lutea in ovaries, by recording the litter weight and number of live and dead fetuses and by analyzing possible skeleton and viscera malformations in the fetuses. Also, the aqueous extract promoted decreased post-implantation loss when compared to the control group. The aqueous and ethanol extracts from B. monandra dried leaves (1,400 or 7,000 mg/kg/day) did not cause maternal or fetal toxicities and the aqueous extract promoted increased implantation and decreased post-implantation loss in the pregnant rats.
Mendes
Caio C
CC
Universidade Federal do Rio Grande do Norte, CEP 59010-180, Natal, RN, Brazil.
Marinho
Ciro M F
CM
Moreira-Junior
Valderes F
VF
Queiroz
Fernando M
FM
Dantas
Gláucia L S
GL
Macedo
Márcia F S
MF
Oliveira
Cláudia N
CN
Schwarz
Aline
A
D000014:Abnormalities, Drug-Induced; D000818:Animals; D036481:Bauhinia; D001835:Body Weight / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004435:Eating / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005333:Fetus / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy / Q000009:adverse effects*; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity*; D018515:Plant Leaves; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*
D010936:Plant Extracts