title: Neuromyelitis optica associated with subacute human T-lymphotropic virus type 1 infection.
abstract: Although human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy, or tropical spastic paraparesis (HAM/TSP), is usually considered as a progressive myelopathy, a subacute variant has been described. It is unusual for optic neuritis (ON) to be associated with an HTLV-1 infection. Neuromyelitis optica (NMO) is characterised by severe attacks of acute transverse myelitis and ON of unknown aetiology. We report a 61-year-old Afro-Caribbean male patient with subacute HAM/TSP associated with bilateral ON that occurred 5years previously. To our knowledge this is the first report of recurrent NMO syndrome associated with HTLV-1 infection.
authors.affiliation: Neurology Department, Centre Hospitalier Universitaire de Fort-de-France, Hôpital Pierre Zobda Quitman, BP 632, Fort-de-France 97261, Martinique, France. stephane.olindo@chu-fortdefrance.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Olindo
authors.forename: Mickaël
authors.initials: M
authors.lastname: Bonnan
authors.forename: Harold
authors.initials: H
authors.lastname: Merle
authors.forename: Aïssatou
authors.initials: A
authors.lastname: Signate
authors.forename: Didier
authors.initials: D
authors.lastname: Smadja
authors.forename: Philippe
authors.initials: P
authors.lastname: Cabre
mesh_terms: D006800:Deltaretrovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D009900:Optic Nerve / Q000473:pathology / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013116:Spinal Cord / Q000473:pathology / Q000821:virology
chemical_list: D008775:Methylprednisolone