Discovery of a novel Hsp90 inhibitor by fragment linking.
Barker
John J
JJ
Evotec, Abingdon, Oxfordshire, OX14 4SA, UK.
Barker
Oliver
O
Courtney
Stephen M
SM
Gardiner
Mihaly
M
Hesterkamp
Thomas
T
Ichihara
Osamu
O
Mather
Owen
O
Montalbetti
Christian A G N
CA
Müller
Annett
A
Varasi
Mario
M
Whittaker
Mark
M
Yarnold
Christopher J
CJ
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013816:Thermodynamics
C555045:(4-(5-furan-2-yl-3-methyl-1H-pyrazol-4-yl)-butyl)methyl-(7H-purin-6-yl)amine; D018841:HSP90 Heat-Shock Proteins; D011720:Pyrazoles; D000225:Adenine