title: Association between interleukin-6 polymorphisms and periodontitis in Indian non-smokers.
abstract: OBJECTIVE
  Genetic polymorphisms (SNPs) in the interleukin-6 (IL-6) gene have been associated with the presence of periodontitis. The aim of this study was to investigate the association between five SNPs in the IL-6 promoter region and the periodontal status of a rural Indian population.
  
  
  METHODS
  Two hundred and fifty-one systemically healthy volunteers were clinically assessed by a single calibrated examiner and divided into: healthy individuals and periodontitis patients based on the European Workshop on Periodontitis definitions and on a recently suggested definition, which takes into account age and clinical attachment levels. Their genomic DNA was analysed blindly using real-time polymerase chain reaction to study IL-6 variants. The association between genetic factors and the presence of periodontitis was assessed by logistic regression.
  
  
  RESULTS
  The IL-6-174 GG genotype was associated with periodontitis in non-smokers and older subjects (>45 years old). No statistically significant associations were detected between IL-6 haplotypes and periodontal status, after adjusting for confounders.
  
  
  CONCLUSIONS
  The IL-6-174 polymorphism showed some evidence of an association with the periodontal status in non-smokers and older subjects in this rural Indian population. This association might be mediated by the effect of IL-6 on inflammatory responses.
authors.affiliation: Periodontology Unit, Eastman Dental Hospital, University College London (UCL), London, UK.
authors.forename: Fernando
authors.initials: F
authors.lastname: Franch-Chillida
authors.forename: Luigi
authors.initials: L
authors.lastname: Nibali
authors.forename: Isobel
authors.initials: I
authors.lastname: Madden
authors.forename: Nikos
authors.initials: N
authors.lastname: Donos
authors.forename: Peter
authors.initials: P
authors.lastname: Brett
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D015850:Interleukin-6 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012016:Reference Values; D012907:Smoking / Q000235:genetics
chemical_list: D015850:Interleukin-6