Protein-protein interaction map is a key gateway into liver regeneration.
Recent studies indicate that the process of liver regeneration involves multiple signaling pathways and a variety of genes, cytokines and growth factors. Protein-protein interactions (PPIs) play a role in nearly all events that take place within the cell and PPI maps should be helpful in further understanding the process of liver regeneration. In this review, we discuss recent progress in understanding the PPIs that occur during liver regeneration especially those in the transforming growth factor beta signaling pathways. We believe the use of large-scale PPI maps for integrating the information already known about the liver regeneration is a useful approach in understanding liver regeneration from the standpoint of systems biology.
Xie
Chao
C
School of Agriculture and Biology, Shanghai Municipality Key Laboratory of Veterinary Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Gao
Jin
J
Zhu
Run-Zhi
RZ
Yuan
Yun-Sheng
YS
He
Hong-Lin
HL
Huang
Qiu-Shi
QS
Han
Wei
W
Yu
Yan
Y
D000465:Algorithms; D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D008115:Liver Regeneration / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D025941:Protein Interaction Mapping; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D016212:Transforming Growth Factor beta