title: [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].
abstract: OBJECTIVE
  To examine the effects of cocaine on the activities of ATPase, LDH and SDH in cultured mouse splenocytes in vitro.
  
  
  METHODS
  The ATPase, LDH and SDH activities in mouse splenocytes were detected at day 7 after continuous culturing the mouse cells exposed to cocaine hydrochloride in final concentration of 10, 20 and 100 microg/mL in vitro.
  
  
  RESULTS
  The activities of ATPase, LDH and SDH in mouse splenocytes exposed to cocaine hydrochloride in final concentration of 10, 20 and 100 microg/mL were significantly decreased after continuous culturing for 7 days.
  
  
  CONCLUSIONS
  The present study demonstrated that cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes in vitro.
authors.affiliation: Department of Forensic Pathology, Taishan Medical College, Taian 271000, China. wenpingsun@163.com
authors.forename: Wen-ping
authors.initials: WP
authors.lastname: Sun
authors.forename: Yan-xu
authors.initials: YX
authors.lastname: Lu
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Zhang
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Tang
authors.forename: Qing-yu
authors.initials: QY
authors.lastname: Huang
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
chemical_list: D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases; D003042:Cocaine