title: Long-term effects of neonatal drugs on the kidney.
abstract: Several drugs have been shown to produce an adverse affect on kidneys, mainly when exposure occurred during active nephrogenesis (pregnancy or prematurity). Several experimental studies on drug-related renal injury have been done on animal models. Observational reports on early drug-related nephrotoxicity in humans are increasing. The investigations regard nephrotoxicity from antibiotics (particularly aminoglycosides), angiotensin-converting enzyme (ACE) inhibitors, non-steroidal anti-inflammatory drugs and antifungins. Few reports have been specifically on the long-term effects on kidneys of drugs given to newborns during active nephrogenesis. Most observations were targeted to investigate long-term renal effects of prematurity and intrauterine growth retardation (IUGR). Nephrotoxic medication taken during fetal life and during postnatal nephrogenesis could interfere with nephron generation contributing to a particular magnitude of damage. Such adjunctive damage could further increase the risk of renal failure in the adulthood of children born prematurely.
authors.affiliation: Section of Pediatrics, Department of Life and Reproduction Sciences, University of Verona, Piazzale L. Scuro 10, Verona, Italy. marco.zaffanello@univr.it
authors.forename: Marco
authors.initials: M
authors.lastname: Zaffanello
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Bassareo
authors.forename: Luigi
authors.initials: L
authors.lastname: Cataldi
authors.forename: Roberto
authors.initials: R
authors.lastname: Antonucci
authors.forename: Paolo
authors.initials: P
authors.lastname: Biban
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D015931:Intensive Care, Neonatal / Q000379:methods; D007674:Kidney Diseases / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000894:Anti-Inflammatory Agents, Non-Steroidal