Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor.
Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT(1A) receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT(1A)-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT(1A) receptor as well as a 5-HT(1A)-agonist activity in a 8-OH-DPAT-stimulated [(35)S]GTP-gammaS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT(1A) receptors.
Shin
Eun-Joo
EJ
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
Whang
Wan Kyunn
WK
Kim
Sungun
S
Bach
Jae-Hyung
JH
Kim
Jin-Man
JM
Nguyen
Xuan-Khanh Thi
XK
Nguyen
Thuy-Ty Lan
TT
Jung
Bae Dong
BD
Yamada
Kiyofumi
K
Nabeshima
Toshitaka
T
Kim
Hyoung-Chun
HC
D000818:Animals; D002951:Citrates / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D051379:Mice; D010622:Phencyclidine / Q000633:toxicity*; D011618:Psychotic Disorders / Q000517:prevention & control*; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D012559:Schizophrenia / Q000517:prevention & control*
D002951:Citrates; D005960:Glucosides; C554064:parishin C; D044282:Receptor, Serotonin, 5-HT1A; D010622:Phencyclidine