title: Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival.
abstract: OBJECTIVE
  To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge.
  
  
  METHODS
  Retrospective matched-pair cohort study.
  
  
  METHODS
  Memorial Sloan-Kettering Cancer Center, New York, New York.
  
  
  METHODS
  A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue.
  
  
  METHODS
  Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).
  
  
  RESULTS
  The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P = .97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P = .90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P = .54).
  
  
  CONCLUSIONS
  When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients.
authors.affiliation: Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.
authors.forename: Luc G T
authors.initials: LG
authors.lastname: Morris
authors.forename: Snehal G
authors.initials: SG
authors.lastname: Patel
authors.forename: Jatin P
authors.initials: JP
authors.lastname: Shah
authors.forename: Ian
authors.initials: I
authors.lastname: Ganly
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D016555:Matched-Pair Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D019647:Oral Surgical Procedures / Q000379:methods; D011336:Probability; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D055815:Young Adult