title: In vivo immunomodulatory activities of the aqueous extract of bonduc nut Caesalpinia bonducella seeds.
abstract: This study evaluated the in vivo immunomodulatory activities of the aqueous extract of Caesalpinia bonducella Fleming (Caesalpiniaceae) seeds. C. bonducella is a plant widely used in the traditional medicinal systems of India. In the present investigation, the aqueous extract of C. bonducella seeds was tested for its effect on cell mediated and humoral components of the immune system in rats. Administration of C. bonducella seed extract produced an increase of 93.03 +/- 4 mean hemagglutinating antibody (HA) titer and a change of 0.56 +/- 0.058 mm in delayed type hypersensitivity (DTH) as compared to control at a dose of 400 mg/kg body weight. Thus, the results of this study indicate that C. bonducella extract could be a promising immunostimulatory agent.
authors.affiliation: Faculty of Life Sciences, Dr. H.S. Gour University, Sagar, Madhya Pradesh, India. s.microb@yahoo.com
authors.forename: Shruti
authors.initials: S
authors.lastname: Shukla
authors.forename: Archana
authors.initials: A
authors.lastname: Mehta
authors.forename: Pradeep
authors.initials: P
authors.lastname: Mehta
authors.forename: Suresh Prasad
authors.initials: SP
authors.lastname: Vyas
authors.forename: Hebbani Nagarajappa
authors.initials: HN
authors.lastname: Shivaprasad
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D000906:Antibodies / Q000097:blood; D029911:Caesalpinia / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006388:Hemagglutinins / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000097:blood / Q000276:immunology; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D056747:Immunomodulation / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity; D051381:Rats; D012639:Seeds / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D000906:Antibodies; D006388:Hemagglutinins; D010936:Plant Extracts