Lifestyle interventions, insulin resistance, and renal artery stiffness in essential hypertension.
The study investigates lifestyle and effective anti-hypertensive intervention in overweight-obese patients can influence insulin-resistance (HOMA-IR) and US Renal-Resistive-Index (RRI). After a 1-year interventional program (including a personalized Mediterranean diet, physical activity increase, smoking withdrawal counseling), 156 Essential Hypertension (EH) patients still have abnormal HOMA-IR, significantly higher in comparison to 159 control group patients. Body mass index (BMI) and cholesterol-high-density-lipoprotein improvement are the best predictors of a HOMA-IR decrease; RRI improves in EH according to lifestyle interventions, but no predictor to RRI is identified. Persistence of IR can be tentatively assumed as a steady sign, persistent also after extended lifestyle intervention in EH, further warranting more intensive dietary interventions.
Trovato
Guglielmo M
GM
Dipartimento di Medicina Interna, Istituto di Medicina Interna e Terapia Medica Facoltà di Medicina e Chirurgia, Università di Catania, Italy. guglielmotrovato@unict.it
Pirri
Clara
C
Martines
Giuseppe Fabio
GF
Tonzuso
Antonia
A
Trovato
Francesca
F
Catalano
Daniela
D
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D004032:Diet; D004548:Elasticity / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy*; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D008875:Middle Aged; D009043:Motor Activity; D012077:Renal Artery / Q000502:physiology*; D016540:Smoking Cessation; D016896:Treatment Outcome