title: Medicinal chemistry as a conduit for the modulation of quorum sensing.
authors.affiliation: Department of Chemistry and Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Colin A
authors.initials: CA
authors.lastname: Lowery
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Salzameda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sawada
authors.forename: Gunnar F
authors.initials: GF
authors.lastname: Kaufmann
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda
mesh_terms: D054742:Acyl-Butyrolactones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D055808:Drug Discovery; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006714:Homoserine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010420:Pentanes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D053038:Quorum Sensing / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C493138:4,5-dihydroxy-2,3-pentanedione; D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D010420:Pentanes; D010456:Peptides, Cyclic; D006714:Homoserine