title: Targeting circuits of sexual desire as a treatment strategy for hypoactive sexual desire disorder.
abstract: Hypoactive sexual desire disorder (HSDD) is hypothesized to be a disorder of the brain's reward circuitry. Neurotransmitters in reward circuits are thus therapeutic targets for improving sexual desire. Novel treatment strategies are to enhance dopamine (DA) actions, reduce serotonin (5-HT) actions, or both.
authors.affiliation: Neuroscience Education Institute in Carlsbad, California, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001931:Brain Mapping; D004298:Dopamine / Q000502:physiology; D015259:Dopamine Agents / Q000627:therapeutic use; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D020249:Hormone Replacement Therapy; D006801:Humans; D007989:Libido / Q000187:drug effects*; D053486:Melanocortins / Q000502:physiology; D009415:Nerve Net / Q000187:drug effects*; D010121:Oxytocin / Q000502:physiology; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000627:therapeutic use; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D015259:Dopamine Agents; D053486:Melanocortins; D011619:Psychotropic Drugs; D012702:Serotonin Antagonists; D012701:Serotonin; D010121:Oxytocin; D004298:Dopamine