A second signal for autophagic cell death?
Dictyostelium cells in monolayers in vitro lend themselves well to a study of autophagic cell death (ACD). There is no apoptosis machinery in the protist Dictyostelium, no caspase nor Bcl-2 family members (except a paracaspase whose inactivation does not alter cell death), thus there is no apoptosis that could interfere with, or substitute for, nonapoptotic cell death. Also, Dictyostelium, a eukaryote, has a haploid genome, which facilitates random insertional mutagenesis.
Giusti
Corinne
C
Centre d'Immunologie de Marseille-Luminy, Faculté des Sciences de Luminy, Aix Marseille Université, Marseille, France.
Luciani
Marie-Françoise
MF
Golstein
Pierre
P
D000818:Animals; D001343:Autophagy; D004023:Dictyostelium / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D017125:Genes, Protozoan; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D015800:Protozoan Proteins / Q000378:metabolism; D015398:Signal Transduction
D015800:Protozoan Proteins