[Neurobiology of sleep apnea: implication for therapy?].
An accumulating body of evidence from animal investigations supports the potential importance of vagal afferent pathways in the pathogenesis and/or therapy of SRBD. The neurochemistry and neuropharmacology of this pathway offers numerous possible targets for pharmacologic modulation. Defining the ultimate clinical relevance of these pathways in SRBD pathogenesis and treatment can only be accomplished with significant ongoing clinical and basic investigation.
D000818:Animals; D006801:Humans; D009420:Nervous System / Q000503:physiopathology*; D009620:Nodose Ganglion / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000188:drug therapy / Q000503:physiopathology*; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology