Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays.
Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.
Pui
Tze-Sian
TS
Institute of Microelectronics, A*STAR (Agency for Science, Technology and Research), 11 Science Park Road, 117685 Singapore.
Agarwal
Ajay
A
Ye
Feng
F
Tou
Zhi-Qiang
ZQ
Huang
Yinxi
Y
Chen
Peng
P
D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002460:Cell Line; D057230:Limit of Detection; D051379:Mice; D046529:Microscopy, Electron, Transmission; D053770:Nanowires / Q000737:chemistry*; D012666:Semiconductors; D012825:Silicon / Q000737:chemistry*
D054392:Adipokines; D012825:Silicon