Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
Liu
Xiangdong
X
University Health Network, Toronto, Ontario, Canada.
Invernizzi
Pietro
P
Lu
Yue
Y
Kosoy
Roman
R
Lu
Yan
Y
Bianchi
Ilaria
I
Podda
Mauro
M
Xu
Chun
C
Xie
Gang
G
Macciardi
Fabio
F
Selmi
Carlo
C
Lupoli
Sara
S
Shigeta
Russell
R
Ransom
Michael
M
Lleo
Ana
A
Lee
Annette T
AT
Mason
Andrew L
AL
Myers
Robert P
RP
Peltekian
Kevork M
KM
Ghent
Cameron N
CN
Bernuzzi
Francesca
F
Zuin
Massimo
M
Rosina
Floriano
F
Borghesio
Elisabetta
E
Floreani
Annarosa
A
Lazzari
Roberta
R
Niro
Grazia
G
Andriulli
Angelo
A
Muratori
Luigi
L
Muratori
Paolo
P
Almasio
Piero L
PL
Andreone
Pietro
P
Margotti
Marzia
M
Brunetto
Maurizia
M
Coco
Barbara
B
Alvaro
Domenico
D
Bragazzi
Maria C
MC
Marra
Fabio
F
Pisano
Alessandro
A
Rigamonti
Cristina
C
Colombo
Massimo
M
Marzioni
Marco
M
Benedetti
Antonio
A
Fabris
Luca
L
Strazzabosco
Mario
M
Portincasa
Piero
P
Palmieri
Vincenzo O
VO
Tiribelli
Claudio
C
Croce
Lory
L
Bruno
Savino
S
Rossi
Sonia
S
Vinci
Maria
M
Prisco
Cleofe
C
Mattalia
Alberto
A
Toniutto
Pierluigi
P
Picciotto
Antonio
A
Galli
Andrea
A
Ferrari
Carlo
C
Colombo
Silvia
S
Casella
Giovanni
G
Morini
Lorenzo
L
Caporaso
Nicola
N
Colli
Agostino
A
Spinzi
Giancarlo
G
Montanari
Renzo
R
Gregersen
Peter K
PK
Heathcote
E Jenny
EJ
Hirschfield
Gideon M
GM
Siminovitch
Katherine A
KA
Amos
Christopher I
CI
Gershwin
M Eric
ME
Seldin
Michael F
MF
D000483:Alleles; D002170:Canada; D016678:Genome; D055106:Genome-Wide Association Study; D006801:Humans; D050835:Interferon Regulatory Factors; D008105:Liver Cirrhosis, Biliary; D015201:Meta-Analysis as Topic; D016017:Odds Ratio; D044465:White People / Q000235:genetics*
C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors