Cycle 1 as predictor of assisted reproductive technology treatment outcome over multiple cycles: an analysis of linked cycles from the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System online database.
OBJECTIVE
To determine whether the first cycle of assisted reproductive technology (ART) predicts treatment course and outcome.


METHODS
Retrospective study of linked cycles.


METHODS
Society for Assisted Reproductive Technology Clinic Outcome Reporting System database.


METHODS
A total of 6,352 ART patients residing or treated in Massachusetts with first treatment cycle in 2004-2005 using fresh, autologous oocytes and no prior ART. Women were categorized by first cycle as follows: Group I, no retrieval; Group II, retrieval, no transfer; Group III, transfer, no embryo cryopreservation; Group IV, transfer plus cryopreservation; and Group V, all embryos cryopreserved.


METHODS
None.


METHODS
Cumulative live-birth delivery per woman, use of donor eggs, intracytoplasmic sperm injection (ICSI), or frozen embryo transfers (FET).


RESULTS
Groups differed in age, baseline FSH level, prior gravidity, diagnosis, and failure to return for Cycle 2. Live-birth delivery per woman for groups I through V for women with no delivery in Cycle I were 32.1%, 35.9%, 40.1%, 53.4%, and 51.3%, respectively. Groups I and II were more likely to subsequently use donor eggs (14.5% and 10.9%). Group II had the highest use of ICSI (73.3%); Group III had the lowest use of FET (8.9%).


CONCLUSIONS
Course of treatment in the first ART cycle is related to different cumulative live-birth delivery rates and eventual use of donor egg, ICSI, and FET.
Stern
Judy E
JE
Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. Judy.E.Stern@Dartmouth.edu
Brown
Morton B
MB
Luke
Barbara
B
Wantman
Ethan
E
Lederman
Avi
A
Hornstein
Mark D
MD
D000554:Ambulatory Care Facilities / Q000706:statistics & numerical data; D016208:Databases, Factual / Q000706:statistics & numerical data; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D005260:Female; D006801:Humans; D007246:Infertility / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology; D009862:Online Systems; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012955:Societies, Medical; D016896:Treatment Outcome