eGFR is associated with subclinical atherosclerosis independent of albuminuria: the Dong-gu Study.
OBJECTIVE
This study evaluated the relationships between estimated glomerular filtration rate (eGFR) and carotid atherosclerosis, peripheral arterial disease (PAD), arterial stiffness, and left ventricular hypertrophy, independent of albuminuria.


METHODS
The study population consisted of 6694 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2009. The common carotid artery intima-media thickness (CCA-IMT), carotid plaque, ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and left ventricular mass index (LVMI) of each subjects was assessed.


RESULTS
After adjustment for risk factors and albumin-creatinine ratio (ACR), kidney dysfunction (eGFR=30-44 ml/min per 1.73 m2) was significantly associated with carotid plaque presence (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.21-2.53) and PAD (OR, 2.64; 95% CI, 1.51-4.62) compared to normal kidney function (eGFR≥60 ml/min per 1.73 m2). Similarly, mean LVMI and baPWV differed significantly according to eGFR after adjustment for other risk factors and ACR; in contrast, no significant difference was observed for CCA-IMT.


CONCLUSIONS
Independent of albuminuria, eGFR is associated with carotid plaque, PAD, baPWV, and LVMI but not with CCA-IMT in Koreans aged 50 years and older.
Choi
Seong-Woo
SW
Department of Overseas Hospital Consulting, Korea Health Industry Development Institute, 57-1, Norayngjin-dong, Dongjak-gu, Seoul 156-800, Republic of Korea.
Kim
Hye-Yeon
HY
Lee
Young-Hoon
YH
Ryu
So-Yeon
SY
Kweon
Sun-Seog
SS
Rhee
Jung-Ae
JA
Choi
Jin-Su
JS
Shin
Min-Ho
MH
D000328:Adult; D000419:Albuminuria / Q000175:diagnosis*; D050197:Atherosclerosis / Q000150:complications* / Q000175:diagnosis*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D004452:Echocardiography / Q000379:methods; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007723:Korea; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000473:pathology; D012307:Risk Factors; D014463:Ultrasonography / Q000379:methods