title: Giving Alzheimer's the old one-two.
abstract: A dual goal for treating Alzheimer's disease (AD) is to decrease deposition of neurotoxic amyloid beta-peptide in the brain and to boost repair of damaged neurons. Donmez et al. (2010) now show that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid receptor beta, a potential new therapeutic target for AD.
authors.affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mwolfe@rics.bwh.harvard.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolfe
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Selkoe