[Localization diagnosis of carcinoma in situ of bladder cancer by pirarubicin: preliminary clinical experience].
OBJECTIVE
To investigate whether the location of carcinoma in situ (CIS) of bladder cancer could be macroscopically ascertained by instilling pirarubicin (THP) into urinary bladder.


METHODS
50 mg of THP was dissolved into 50 ml of 5% glucose solution. And the resulting solution was instilled into urinary bladder. After 15 min, the urinary bladder was observed by a cystoscopy. The study group consisted of 51 patients with bladder cancer (37 males, 14 females) and 14 patients with hematuria (8 males, 6 females), treated at our hospital from December 2007 to June 2008.


RESULTS
The THP uptake was seen in 67 flat (non-tumorous) areas of bladder mucosa in 37 patients with bladder cancer. Of these, 11 lesions in 7 patients were confirmed to be CIS. The THP uptake was found in 2 flat (non-tumorous) areas of bladder mucosa in 14 patients with hematuria, 1 lesion in 1 patient was confirmed to be CIS. The sensitivity and specificity of THP uptake by CIS were 92.3% (12/13) and 86.7% (371/428) respectively.


CONCLUSIONS
This practical method may be employed to ascertain easily the macroscopic location of CIS of bladder cancer.
Xia
Shu-jie
SJ
Department of Urology, First People's Hospital, Affiliated to Shanghai Jiaotong University, Institute of Urological Research, Shanghai Jiaotong University, Shanghai, China. xsjurologist@163.com
Liu
Hai-tao
HT
Ruan
Yuan
Y
Xue
Song
S
Zhang
Jie
J
Sun
Xiao-wen
XW
Han
Bang-min
BM
Zhu
Yi-yong
YY
Zhuo
Jian
J
D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis*; D004317:Doxorubicin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
D004317:Doxorubicin; C027260:pirarubicin