title: Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil.
abstract: This study investigated some pharmacological properties of virgin coconut oil (VCO), the natural pure oil from coconut [Cocos nucifera Linn (Palmae)] milk, which was prepared without using chemical or high-heat treatment. The anti-inflammatory, analgesic, and antipyretic effects of VCO were assessed. In acute inflammatory models, VCO showed moderate anti-inflammatory effects on ethyl phenylpropiolate-induced ear edema in rats, and carrageenin- and arachidonic acid-induced paw edema. VCO exhibited an inhibitory effect on chronic inflammation by reducing the transudative weight, granuloma formation, and serum alkaline phosphatase activity. VCO also showed a moderate analgesic effect on the acetic acid-induced writhing response as well as an antipyretic effect in yeast-induced hyperthermia. The results obtained suggest anti-inflammatory, analgesic, and antipyretic properties of VCO.
authors.affiliation: McCormick Faculty of Nursing, Payap University, Chiang Mai, Thailand. sophaphan_in@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Intahphuak
authors.forename: P
authors.initials: P
authors.lastname: Khonsung
authors.forename: A
authors.initials: A
authors.lastname: Panthong
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000627:therapeutic use*; D058633:Antipyretics / Q000737:chemistry / Q000627:therapeutic use*; D000074263:Coconut Oil; D003059:Cocos / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005227:Fatty Acids / Q000032:analysis; D005334:Fever / Q000188:drug therapy*; D005638:Fruit / Q000737:chemistry; D006099:Granuloma / Q000097:blood / Q000473:pathology / Q000517:prevention & control; D006930:Hyperalgesia / Q000139:chemically induced / Q000517:prevention & control*; D006979:Hyperthermia, Induced; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D011749:Pyrogens / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D005227:Fatty Acids; D010938:Plant Oils; D011749:Pyrogens; D000469:Alkaline Phosphatase; D000074263:Coconut Oil