Gout in pediatric renal transplant recipients.
Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who presented with gouty arthritis 7-8.5 years following RTx. Since receiving allopurinol, all patients had been free of gouty symptoms. To prevent severe bone marrow depletion, the dosage of azathioprine, an immunosupressant drug, was reduced by 50% to prevent interaction with allopurinol. Because atypical presentation of gout can occur, a high index of suspicion is needed to allow appropriate diagnosis of this disease in patients with skeletal pain after RTx.
Trück
Johannes
J
Department of Pediatrics, Triemli Hospital Zurich, Birmensdorferstrasse 497, Zurich, Switzerland.
Laube
Guido F
GF
von Vigier
Rodo O
RO
Goetschel
Philippe
P
D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D001379:Azathioprine / Q000008:administration & dosage; D001706:Biopsy; D002648:Child; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D016896:Treatment Outcome
D006074:Gout Suppressants; D007166:Immunosuppressive Agents; D000493:Allopurinol; D001379:Azathioprine