title: Mycobacterium tuberculosis wears what it eats.
abstract: Mycobacterium tuberculosis remains one of the most pernicious of human pathogens. Current vaccines are ineffective, and drugs, although efficacious, require prolonged treatment with constant medical oversight. Overcoming these problems requires a greater appreciation of M. tuberculosis in the context of its host. Upon infection of either macrophages in culture or animal models, the bacterium realigns its metabolism in response to the new environments it encounters. Understanding these environments, and the stresses that they place on M. tuberculosis, should provide insights invaluable for the development of new chemo- and immunotherapeutic strategies.
authors.affiliation: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Russell
authors.forename: Brian C
authors.initials: BC
authors.lastname: VanderVen
authors.forename: Wonsik
authors.initials: W
authors.lastname: Lee
authors.forename: Robert B
authors.initials: RB
authors.lastname: Abramovitch
authors.forename: Mi-jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Susanne
authors.initials: S
authors.lastname: Homolka
authors.forename: Stefan
authors.initials: S
authors.lastname: Niemann
authors.forename: Kyle H
authors.initials: KH
authors.lastname: Rohde
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D050356:Lipid Metabolism; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000502:physiology*; D013312:Stress, Physiological; D014376:Tuberculosis / Q000378:metabolism / Q000382:microbiology*