title: Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.
abstract: We test whether plasma level of methylglyoxal (MG) is an independent risk factor predicting the progression of diabetic macroangiopathy or microangiopathy in type 2 diabetic patients. We measured in 50 type 2 diabetic patients plasma levels of MG and 3-deoxyglucosone (DG) using an electrospray ionization-liquid chromatography-mass spectrometry. We assessed the correlations between baseline levels of MG or DG and the percentage changes after 5 years of clinical parameters linked to diabetic macroangiopathy or microangiopathy, that is, intima-media thickness (IMT), systolic blood pressure (SBP), the amount of urinary albumin excretion (ACR), pulse wave velocity (PWV), and estimated glomerular filtration rate (eGFR). Multiple regression analysis was performed using the percentage changes in IMT, SBP, ACR, PWV, and eGFR over the 5-year period as the independent or objective variables and the values of MG, DG, glycohemoglobin A1c, body mass index, triglyceride, and diabetic duration at the baseline as the dependent variables. The values of IMT, PWV, SBP, and ACR all increase, but eGFR reduces with time during the 5-year period. Baseline level of MG correlates significantly with the percentage changes of IMT, SBP, ACR, PWV, and eGFR, whereas that of DG does only with ACR. A multiple regression analysis reveals that MG is an independent risk factor for the percentage changes of IMT, PWV, and SBP but not for those of ACR and eGFR. DG is an independent risk factor for the percentage change of ACR. MG is a predictor in type 2 diabetic patients of intima-media thickening, of increase of PWV, and of elevation of SBP.
authors.affiliation: Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. ogawa-s@mail.tains.tohoku.ac.jp
authors.forename: Susumu
authors.initials: S
authors.lastname: Ogawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakayama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama
authors.forename: Takefumi
authors.initials: T
authors.lastname: Mori
authors.forename: Masato
authors.initials: M
authors.lastname: Matsushima
authors.forename: Masashi
authors.initials: M
authors.lastname: Okamura
authors.forename: Miho
authors.initials: M
authors.lastname: Senda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nako
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyata
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D011446:Prospective Studies; D011765:Pyruvaldehyde / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D017539:Tunica Intima / Q000503:physiopathology*; D017540:Tunica Media / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D011765:Pyruvaldehyde