title: Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels.
abstract: Royal Jelly (RJ) is used in the Turkish folk medicine for the treatment of number of disorders. The present study describes the hepatoprotective and antioxidant activities of the RJ against carbon tetrachloride (CCl(4))-induced acute liver damage. Sprague-Dawley rats were used for the experiment. CCl(4) (0.8 ml/kg; s.c.) and RJ (50, 100, 200mg/kg; orally) were given every other day, for 20 days. Malondialdehyde, reduced glutathione in whole blood and tissues; ceruloplasmin, sialic acid, ascorbic acid, retinol, β-carotene and liver enzymes levels in serum were measured. Additionally, histopathological alterations in the liver were examined. RJ exerted the significant protective effect on liver damage as well as on oxidative stress induced by CCl(4), resulting in reduced lipid peroxidation and improved endogenous antioxidant defence systems. It also reduced the elevated levels of liver enzymes. Histopathological study further confirmed the hepatoprotective effect of RJ, when compared with the CCl(4) treated control groups. In conclusion, present study reveals biological evidence that supports the use of RJ in the treatment of chemical-induced hepatotoxicity.
authors.affiliation: Department of Chemistry, Biochemistry Division, Faculty of Sciences and Arts, Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cemek
authors.forename: Fatih
authors.initials: F
authors.lastname: Aymelek
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Büyükokuroğlu
authors.forename: Turan
authors.initials: T
authors.lastname: Karaca
authors.forename: Ahmet
authors.initials: A
authors.lastname: Büyükben
authors.forename: Fatma
authors.initials: F
authors.lastname: Yilmaz
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001205:Ascorbic Acid / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000097:blood* / Q000473:pathology / Q000517:prevention & control*; D005227:Fatty Acids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D020011:Protective Agents; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000097:blood; D014815:Vitamins / Q000097:blood; D019207:beta Carotene / Q000097:blood; D000099219:Royal Jelly
chemical_list: D000410:Alanine Transaminase; D000975:Antioxidants; D001205:Ascorbic Acid; D001219:Aspartate Aminotransferases; D005227:Fatty Acids; D005978:Glutathione; D008315:Malondialdehyde; D019158:N-Acetylneuraminic Acid; D020011:Protective Agents; D014801:Vitamin A; D014815:Vitamins; D019207:beta Carotene; D000099219:Royal Jelly