title: Physical activity does not influence the effect of antioxidant supplementation at nutritional doses on the incidence of impaired fasting glucose: a 7.5 year post-hoc analysis from the SU.VI.MAX study.
abstract: Supplementation with high doses of antioxidant vitamins prevents the insulin-sensitizing effects of physical exercise. However, little is known whether antioxidant supplementation affects the incidence of impaired fasting glucose (IFG). Data from 8938 subjects included in a randomized controlled trial on supplementation with antioxidants vitamins and trace elements at nutritional doses (SU.VI.MAX) were used to examine the effects of antioxidants on incident IFG after 7.5 years of follow-up, with and without stratification for daily physical exercise. The odds-ratio (95% CI) for developing an IFG among study participants receiving antioxidant supplementation was 1.34 (0.90-1.97) (p=0.33), in comparison to placebo. This risk did not vary significantly according to physical activity level (p for homogeneity=0.10). Supplementation with trace elements and antioxidants at nutritional doses apparently does not affect the incidence of IFG irrespective of self-reported physical exercise habits.
authors.affiliation: Unité de Recherche en Epidémiologie Nutritionnelle-UMR U557 INSERM, U1125 INRA, CNAM, Université Paris 13, CRNH-IdF, Bobigny, France.
authors.forename: L
authors.initials: L
authors.lastname: Fezeu
authors.forename: A
authors.initials: A
authors.lastname: Henegar
authors.forename: E
authors.initials: E
authors.lastname: Kesse-Guyot
authors.forename: C
authors.initials: C
authors.lastname: Julia
authors.forename: P
authors.initials: P
authors.lastname: Galan
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
authors.forename: M
authors.initials: M
authors.lastname: Ristow
authors.forename: S
authors.initials: S
authors.lastname: Czernichow
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects*; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D005947:Glucose