title: Retinal safety of the irradiation delivered to light-adjustable intraocular lenses evaluated in a rabbit model.
abstract: OBJECTIVE
  To evaluate the safety to the retina of a light-delivery device used to irradiate a light-adjustable intraocular lens (IOL) after implantation in a rabbit model.
  
  
  METHODS
  John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  In this study, rabbits had phacoemulsification with implantation of an ultraviolet (UV)-filtering light-adjustable IOL (study IOL) in 1 eye and a custom-made silicone IOL without a UV filter (control IOL) in the opposite eye. The study IOLs were irradiated at 1.0, 2.0, 3.0, and 5.0 times the expected maximum UV irradiation doses and the control IOLs, at 0.3, 0.6, 1.0, and 2.0 times. One week after irradiation, slitlamp and fundus (indirect ophthalmoscopy) examinations were performed. The rabbits were then humanely killed and their eyes enucleated and processed for histopathology.
  
  
  RESULTS
  The 16 eyes with the study IOL (with UV filter) showed no signs of corneal, anterior segment, or retinal toxicity on histopathologic evaluation. The 16 eyes with the control IOL (no UV filter) also showed no signs of corneal or anterior segment toxicity; however, 3 eyes receiving the higher radiation doses had focal areas of retinal damage consistent with laser burn.
  
  
  CONCLUSIONS
  Pigmented rabbit eyes with a light-adjustable IOL with a UV filter showed no signs of retina toxicity after near-UV light exposure up to 5 times the expected maximum treatment dosage.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.
authors.affiliation: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA. liliana.werner@hsc.utah.edu
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Wellington
authors.initials: W
authors.lastname: Chang
authors.forename: Jonathan
authors.initials: J
authors.lastname: Haymore
authors.forename: Brian
authors.initials: B
authors.lastname: Haugen
authors.forename: Natalya
authors.initials: N
authors.lastname: Romaniv
authors.forename: Christian
authors.initials: C
authors.lastname: Sandstedt
authors.forename: Shiao
authors.initials: S
authors.lastname: Chang
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008027:Light / Q000009:adverse effects*; D009887:Ophthalmoscopy; D018918:Phacoemulsification; D011474:Prosthesis Design; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000175:diagnosis / Q000209:etiology*; D012160:Retina / Q000473:pathology / Q000528:radiation effects*
chemical_list: D020099:Coated Materials, Biocompatible