title: A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.
abstract: In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.
authors.affiliation: Department of Chemical Engineering, LTH, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Kaunisto
authors.forename: Susanna
authors.initials: S
authors.lastname: Abrahmsen-Alami
authors.forename: Per
authors.initials: P
authors.lastname: Borgquist
authors.forename: Anette
authors.initials: A
authors.lastname: Larsson
authors.forename: Bernt
authors.initials: B
authors.lastname: Nilsson
authors.forename: Anders
authors.initials: A
authors.lastname: Axelsson
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008956:Models, Chemical; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D012997:Solvents; D013607:Tablets