title: [Thrombotic microangiopathy following kidney transplantation revealing factors H and I deficiencies].
abstract: A 52-year-old man with an end stage renal failure of undetermined aetiology was hemodialysed in 2002. He received a cadaveric kidney transplantation in 2004. After an episode of diarrhea, a thrombotic microangiopathy was diagnosed in July 2009 and during this episode, a low C3 serum level was identified. Plasma exchanges were beneficial. Exploration of the low C3 serum level revealed both factor H and factor I deficiencies. We think that the renal failure of undetermined aetiology was probably an unnoticed haemolytic and uremic syndrome which recurred more than five years after transplantation.
authors.affiliation: Service de médecine interne, centre hospitalier de Béziers, 2 rue Valentin-Hauÿ, Béziers, France. jbfraison@gmail.com
authors.forename: J-B
authors.initials: JB
authors.lastname: Fraison
authors.forename: V
authors.initials: V
authors.lastname: Pernin
authors.forename: C
authors.initials: C
authors.lastname: Alméras
authors.forename: F
authors.initials: F
authors.lastname: Vetromile
authors.forename: V
authors.initials: V
authors.lastname: Frémeaux-Bacchi
authors.forename: G
authors.initials: G
authors.lastname: Mourad
mesh_terms: D017242:Complement Factor H / Q000172:deficiency*; D017244:Complement Factor I / Q000172:deficiency*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D057049:Thrombotic Microangiopathies / Q000209:etiology*
chemical_list: D017242:Complement Factor H; D017244:Complement Factor I