title: Early onset primary pulmonary cryptococcosis in a renal transplant patient.
abstract: We report a case of primary pulmonary cryptococcosis in a post-renal transplant patient. A 65-year-old male renal transplant patient was admitted to the hospital with a low grade fever of 1 month, radiologically mimicking tuberculosis (TB). Broncho-alveolar fluid (BAL) shows capsulated yeast, and Cryptococcus neoformans was grown on culture supported by cytology and histopathological examination. Cryptococcal antigen was positive (32-fold) in serum and was negative in cerebrospinal fluid (CSF). The patient was given amphotericin B and 5-flucytosine and clinical improvement was seen on a weekly follow up. The serum cryptococcal antigen test might contribute to the early detection and treatment of pulmonary cryptococcosis. The results of antifungal susceptibility were aid in selecting the drug of choice for treatment.
authors.affiliation: SRL Clinical Reference Laboratory, Gurgaon, Haryana, India.
authors.forename: B
authors.initials: B
authors.lastname: Tarai
authors.forename: V
authors.initials: V
authors.lastname: Kher
authors.forename: P
authors.initials: P
authors.lastname: Kotru
authors.forename: A
authors.initials: A
authors.lastname: Sabhikhi
authors.forename: P
authors.initials: P
authors.lastname: Barman
authors.forename: A
authors.initials: A
authors.lastname: Rattan
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D003585:Cell Biology; D003453:Cryptococcosis / Q000175:diagnosis* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D005437:Flucytosine / Q000627:therapeutic use; D006651:Histocytochemistry; D006801:Humans; D016030:Kidney Transplantation; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D013902:Radiography, Thoracic; D014180:Transplantation
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine