title: A robust sliding mode controller with internal model for closed-loop artificial pancreas.
abstract: The study presents a robust closed-loop sliding mode controller with internal model for blood glucose control in type-1 diabetes. Type-1 diabetic patients depend on external insulin delivery to keep their blood glucose within near-normal ranges. Closed-loop artificial pancreas is developed to help avoid dangerous, potentially life-threatening hypoglycemia, as well as to prevent complication-inducing hyperglycemia. The proposed controller is designed using a combination of sliding mode and internal model control techniques. To enhance postprandial performance, a feedforward controller is added to inject insulin bolus. Simulation studies have been performed to test the controller, which revealed that the proposed control strategy is able to control the blood glucose well within the safe limits in the presence of meals and measurements errors. The controller shows acceptable robustness against changes in insulin sensitivity, model-patient mismatch, and errors in estimating meal's contents.
authors.affiliation: Department of Electrical, Electronics and Control Engineering, University of Girona, Campus Montilivi, P4, 17071, Girona, Spain. amjadhisham.ahmad@udg.edu
authors.forename: Amjad
authors.initials: A
authors.lastname: Abu-Rmileh
authors.forename: Winston
authors.initials: W
authors.lastname: Garcia-Gabin
authors.forename: Darine
authors.initials: D
authors.lastname: Zambrano
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004334:Drug Administration Schedule; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007332:Insulin Infusion Systems; D008954:Models, Biological; D019397:Pancreas, Artificial
chemical_list: D001786:Blood Glucose; D007328:Insulin