[Effect of wet dressing with Jingjielianqiao decoction on healing of acute radiation-induced skin ulcers in rats].
OBJECTIVE
To observe the pharmacodynamics of Jingjielianqiao decoction in promoting the healing of acute radiation-induced skin ulcers in mice.


METHODS
Skin ulcers were induced in mice by radiation, and Jingjielianqiao decoction, rivanol or normal saline was applied for the treatment. The swelling of the legs was measured in mice using volumetric method, and the ulcer area after treatment was compared among the 3 groups.


RESULTS
No significant difference was found in the anti-inflammatory effects between Jingjielianqiao decoction group and rivanol group (P>0.05), but a significant difference was noted between Jingjielianqiao decoction group and normal saline group and also between rivanol group and normal saline group (P<0.01). Significant differences were observed in the ulcer healing among the 3 groups (P<0.01).


CONCLUSIONS
Jingjielianqiao decoction can significantly suppress radiation-induced acute inflammation and shows better effect than rivanol in promoting the healing of acute radiation-induced skin ulcer in rats.
Lan
Hai-mei
HM
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chong
Shu-bin
SB
Lai
Mei-sheng
MS
Zeng
Kang
K
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008517:Phytotherapy; D011855:Radiodermatitis / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology; D014945:Wound Healing / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; C529137:jingjielianqiao