Essential thrombocythaemia and its neurological complications.
Essential thrombocythaemia is one of the chronic myeloproliferative neoplasms and is characterised by a sustained platelet count > or = 450 x 10(9)/l. The clinical course is often indolent but a significant number of patients have thrombotic and haemorrhagic complications. A patient with neurological complications is described, and the pathogenesis and clinical features of this disease are reviewed, including its neurological sequelae and management, along with an outline for the investigation of patients with thrombocytosis.
Miller
Thomas D
TD
Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Farquharson
Mira H
MH
D000925:Anticoagulants / Q000627:therapeutic use; D001856:Bone Marrow Examination / Q000592:standards; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D000075202:Contraindications; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D013920:Thrombocythemia, Essential / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D055815:Young Adult
D000925:Anticoagulants