Tissue distribution of (35)S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure.
Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival. Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to (35)S-PFOS (12.5mg/kg), we determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal day 1, PND1) employing whole-body autoradiography and liquid scintillation counting. In dams, levels were highest in liver and lungs. After placental transfer, (35)S-PFOS was present on GD18 at 2-3 times higher levels in lungs, liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were significantly higher than in GD18 fetuses. A heterogeneous distribution of (35)S-PFOS was observed in brains of fetuses and pups, with levels higher than in maternal brain. This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages.
Borg
D
D
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. daniel.borg@ki.se
Bogdanska
J
J
Sundström
M
M
Nobel
S
S
Håkansson
H
H
Bergman
Å
Å
DePierre
J W
JW
Halldin
K
K
Bergström
U
U
D017738:Alkanesulfonic Acids / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus / Q000378:metabolism; D005466:Fluorocarbons / Q000097:blood / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D012588:Scintillation Counting; D013462:Sulfur Radioisotopes; D014018:Tissue Distribution; D051598:Whole Body Imaging
D017738:Alkanesulfonic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; D013462:Sulfur Radioisotopes; C076994:perfluorooctane sulfonic acid