Estimation of clinically important change for visual analog scales measuring chronic temporomandibular disorder pain.
OBJECTIVE
To estimate the clinically important change (CIC) on a 100-mm visual analog scale for pain intensity (VAS-PI) by relating it to the patient's global impression of change (PGIC) in patients with chronic temporomandibular disorder (TMD) pain and to assess the dependency of the CIC on their baseline pain scores.


METHODS
Data from a prospective cohort study with 588 patients with chronic TMD pain were analyzed. The CIC was estimated over a 3-month period, and receiver operating characteristic methods were used to assess the optimal cut-off point. The PGIC category of "much improved" served as an external criterion. Dependency of absolute and percent change on baseline VAS-PI scores was determined by linear regression analysis.


RESULTS
A VAS-PI change score of -19.5 mm and a percent change score of -37.9% were best associated with the concept of CIC. Since patients with high baseline pain required greater absolute reductions in pain to reach a clinically important improvement, percent change scores performed better in classifying improved patients.


CONCLUSIONS
Providing a standard definition of the CIC adds to the interpretability of study results, ie, the estimates will aid in understanding individual patient outcomes.
Emshoff
Rüdiger
R
Orofacial Pain Unit, University Clinic of Oral and Maxillofacial Surgery, Innsbruck Medical University, Innsbruck, Austria. ruediger.emshoff@uki.at
Emshoff
Iris
I
Bertram
Stefan
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001294:Attitude to Health; D002908:Chronic Disease; D015331:Cohort Studies; D004435:Eating / Q000502:physiology; D005157:Facial Pain / Q000145:classification* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008409:Mastication / Q000502:physiology; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods* / Q000706:statistics & numerical data; D017288:Pain Threshold / Q000502:physiology; D017060:Patient Satisfaction; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013705:Temporomandibular Joint Disorders / Q000145:classification* / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult