title: [Particle therapy: carbon ions].
abstract: Carbon ion therapy is an innovative radiation therapy. It has been first proposed in the forties by Robert Wilson, however the first dedicated centres for human care have been build up only recently in Japan and Germany. The interest of carbon ion is twofold: 1) the very sharp targeting of the tumour with the so called spread out Bragg peak that delivers most of the beam energy in the tumour and nothing beyond it, sparing very efficiently the healthy tissues; 2) the higher relative biological efficiency compared to X rays or protons, able to kill radioresistant tumour cells. Both properties make carbon ions the elective therapy for non resectable radioresistant tumours loco-regionally threatening. The technical and clinical experience accumulated during the recent decades is summarized in this paper along with a detailed presentation of the elective indications. A short comparison between conventional radiotherapy and hadrontherapy is proposed for the indications which are considered as priority for carbon ions.
authors.affiliation: CRLCC Léon-Bérard, Radiothérapie, Lyon, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Pommier
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Baron
authors.forename: Olivier
authors.initials: O
authors.lastname: Chapet
authors.forename: Jacques
authors.initials: J
authors.lastname: Balosso
mesh_terms: D002244:Carbon / Q000627:therapeutic use*; D019583:Dose Fractionation, Radiation; D005602:France; D006801:Humans; D007477:Ions / Q000627:therapeutic use*; D018499:Linear Energy Transfer; D009369:Neoplasms / Q000532:radiotherapy*; D011836:Radiation Tolerance
chemical_list: D007477:Ions; D002244:Carbon