Novel diphenoxo-bridged dinuclear zinc complexes: generation of phenoxyl-radical species and nuclease activity.
Tridentate ligand PhimpH having N(2)O donors binds to zinc(II) after deprotonation, affording novel diphenoxo-bridged dinuclear zinc complexes [Zn(2)(Phimp)(2)(ClO(4))(2)] (1) and [Zn(2)(Phimp)(2)(Cl)(2)] x CH(2)Cl(2) (2 x CH(2)Cl(2)). The molecular structure of 2 x CH(2)Cl(2) revealed some unique structural features. The phenoxyl-radical complexes were generated at room temperature, and these radical complexes exhibited nuclease activity with pBR322 DNA.
Ghosh
Kaushik
K
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. ghoshfcy@iitr.ernet.in
Kumar
Pramod
P
Tyagi
Nidhi
N
Singh
Udai P
UP
D000818:Animals; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism*
D056831:Coordination Complexes; D010636:Phenols; C042329:phenoxy radical; D004247:DNA; C427203:calf thymus DNA; D003851:Deoxyribonucleases; D015032:Zinc