title: "Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site.
abstract: We have demonstrated the fabrication of "aligned-to-random" electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.
authors.affiliation: Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Xie
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Li
authors.forename: Justin
authors.initials: J
authors.lastname: Lipner
authors.forename: Cionne N
authors.initials: CN
authors.lastname: Manning
authors.forename: Annie G
authors.initials: AG
authors.lastname: Schwartz
authors.forename: Stavros
authors.initials: S
authors.lastname: Thomopoulos
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry; D005347:Fibroblasts / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D013314:Stress, Mechanical; D013710:Tendons / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen