Lack of association between ADRA2B-4825 gene insertion/deletion polymorphism and migraine in Chinese Han population.
OBJECTIVE
The present study aimed to estimate the association between susceptibility to migraine and the 12-nucleotide insertion/deletion (indel) polymorphism in promoter region of alpha(2B)-adrenergic receptor gene (ADRA2B).


METHODS
A case-control study was carried out in Chinese Han population, including 368 cases of migraine and 517 controls. Genomic DNA was extracted from blood samples, and DNA fragments containing the site of polymorphism were amplified by PCR. Data were adjusted for sex, age, migraine history and family history, and analyzed using a logistic regression model.


RESULTS
There was no association between indel polymorphism and migraine, at either the allele or the genotype level.


CONCLUSIONS
These findings do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects.
Ni
Jian-Qiang
JQ
Department of Forensic Medicine, Medical College of Soochow University, Suzhou, China.
Jia
Sha-Sha
SS
Liu
Min
M
Chen
Shou-Gong
SG
Jiang
Yu-Ting
YT
Dong
Wan-Li
WL
Gao
Yu-Zhen
YZ
D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D017384:Sequence Deletion / Q000235:genetics*
C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2