[Predictive value of fluorescence in situ hybridization in patients with bladder cancer].
OBJECTIVE
To assess the value of fluorescence in situ hybridization (FISH) in the diagnosis of bladder cancer.


METHODS
Urine samples from 100 patients suspected of having bladder cancer were collected before cystoscopy for immediate urine cytology and FISH analysis. The criteria for FISH abnormality were determined by evaluating the urine specimens from 20 subjects without urogenital neoplasm.


RESULTS
The overall sensitivity of cytology and FISH was 43.2% and 82.4%, and their specificity was 92.3% and 88.5%, with diagnostic concordance rate of 56.0% and 84.0%, respectively. The differences between FISH and cytology showed statistical significance in the sensitivity, diagnostic concordance rate, non-muscle-invasive cancer and primary cancer.


CONCLUSIONS
The sensitivity and efficiency of FISH in the detection of bladder cancer are superior to those of cytology, especially for prophase cancer.
Shan
Zheng-fei
ZF
Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. shzhf0925@gmail.com
Zheng
Shao-bin
SB
Wu
Peng
P
Tan
Wan-long
WL
Zuo
Yi
Y
Zhou
Hai-kuan
HK
Qi
Huan
H
Zhang
Peng
P
Peng
Hong-mei
HM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis*; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*; D014556:Urine / Q000166:cytology; D055815:Young Adult