[Pathological characteristics and clinical significance of macrochilia secondary to venular malformation].
OBJECTIVE
To analyze the histologic characteristics of macrochilia secondary to port-wine stain and to elucidate the possible mechanism.


METHODS
Twenty-one cases of macrochilia secondary to venular malformation were included and the histology of the lesions was observed by light microscope.


RESULTS
Histological examination revealed vascular abnormalities and a number of widely distributed hamartomatous changes in macrochilia secondary to venular malformation. The average vessel diameter is (39.8 +/- 15.7) microm. The degree of hamartomatous change: mild (1 case), moderate (7 cases) and severe (13 cases).


CONCLUSIONS
The complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of venular malformation.
Wang
Wei
W
Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Lin
Xiao-xi
XX
Ma
Gang
G
Li
Wei
W
Hu
Xiao-jie
XJ
Chen
Hui
H
D000293:Adolescent; D000328:Adult; D005260:Female; D006222:Hamartoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008046:Lip / Q000002:abnormalities* / Q000473:pathology; D008047:Lip Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D019339:Port-Wine Stain / Q000150:complications / Q000473:pathology*; D055815:Young Adult