title: Synthesis of N-(methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal nitric oxide synthase.
abstract: Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluated. These novel thienylmethyl-thioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan. gh.suaifan@ju.edu.jo
authors.forename: Ghadeer A R Y
authors.initials: GA
authors.lastname: Suaifan
authors.forename: Claire L M
authors.initials: CL
authors.lastname: Goodyer
authors.forename: Michael D
authors.initials: MD
authors.lastname: Threadgill
mesh_terms: D006801:Humans; D007536:Isomerism; D008722:Methods; D052248:Nitric Oxide Synthase Type I / Q000187:drug effects*; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects*; D013876:Thiophenes / Q000737:chemistry; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D013876:Thiophenes; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D013890:Thiourea