title: Primary and bilateral tubal carcinoma is associated with long-standing granulomatous inflammation and primary infertility: a case report.
abstract: We report a case of bilateral and primary tubal carcinoma associated with granulomatous inflammation and long-standing primary infertility. A 38-year-old woman with a 17-year history of primary infertility presented with lower abdominal pain and granulomatous inflammation in the endometrial biopsy. Bilateral adnexal masses measuring 4 and 6 cm in size were detected and the serum cancer antigen 125 level was 141 IU/ml. Laparoscopic surgical exploration and frozen section on the resected tubes revealed bilateral fallopian tube adenocarcinoma and then a staging laparotomy was performed. Histopathological examination showed a primary bilateral Grade 2 tubal serous adenocarcinoma of Stage 1b associated with granulomatous salpingitis. Primary fallopian tube carcinomas in young women are extremely rare gynecological tumors that are infrequently diagnosed prior to surgical exploration and their cause is unknown. A definitive diagnosis could be made on the histopathological examination in our case with the evidence of chronic pelvic inflammation. Our findings suggest that chronic pelvic inflammation may play a role in carcinogenesis in the tubes of infertile women.
authors.affiliation: Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Research Hospital, Ankara, Turkey.
authors.forename: Muberra
authors.initials: M
authors.lastname: Kocak
authors.forename: Kocak
authors.initials: K
authors.lastname: Muberra
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tasci
authors.forename: Tasci
authors.initials: T
authors.lastname: Yasemin
authors.forename: Nurettin
authors.initials: N
authors.lastname: Boran
authors.forename: Boran
authors.initials: B
authors.lastname: Nurettin
authors.forename: Suhal
authors.initials: S
authors.lastname: Isikdogan
authors.forename: Isikdogan
authors.initials: I
authors.lastname: Zuhal
authors.forename: Berna
authors.initials: B
authors.lastname: Dilbaz
authors.forename: Dilbaz
authors.initials: D
authors.lastname: Berna
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000328:Adult; D005185:Fallopian Tube Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications* / Q000473:pathology; D007249:Inflammation / Q000150:complications / Q000473:pathology