title: Case of polyhydramnios complicated by Opitz G/BBB syndrome.
abstract: Opitz G/BBB syndrome is a congenital disorder characterized by midline defects, such as hypertelorism, cleft lip and/or palate, hypospadias, and by dysphagia often caused by laryngo-tracheo-esophageal abnormalities. We experienced a case of polyhydramnios in a male dichorionic diamniotic (DD) twin, who was diagnosed with Opitz G/BBB syndrome after birth. It is suggested that severe dysphagia was causatively associated with the development of polyhydramnios. In cases of Opitz G/BBB syndrome, boys are usually more heavily affected than girls, who generally manifest only hypertelorism. In the differential diagnosis of polyhydramnios of unidentified cause in male fetuses, it may be helpful to consider maternal facial characteristics, especially hypertelorism.
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tajima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itoh
authors.forename: Ayako
authors.initials: A
authors.lastname: Mochizuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kyuya
authors.initials: K
authors.lastname: Hirai
authors.forename: Kazunao
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugihara
authors.forename: Akira
authors.initials: A
authors.lastname: Ohishi
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ohzeki
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002972:Cleft Palate / Q000235:genetics*; D005260:Female; D006801:Humans; D006972:Hypertelorism / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D006831:Polyhydramnios / Q000175:diagnosis* / Q000235:genetics; D011247:Pregnancy; D013577:Syndrome