Neuritogenic and neuroprotective properties of peptide agonists of the fibroblast growth factor receptor.
Fibroblast growth factor receptors (FGFRs) interact with their cognate ligands, FGFs, and with a number of cell adhesion molecules (CAMs), such as the neural cell adhesion molecule (NCAM), mediating a wide range of events during the development and maintenance of the nervous system. Determination of protein structure, in silico modeling and biological studies have recently resulted in the identification of FGFR binding peptides derived from various FGFs and NCAM mimicking the effects of these molecules with regard to their neuritogenic and neuroprotective properties. This review focuses on recently developed functional peptide agonists of FGFR with possible therapeutic potential.
Li
Shizhong
S
Protein Laboratory, Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen N, Denmark; E-Mails: li@sund.ku.dk (S.L.); bock@sund.ku.dk (E.B.).
Bock
Elisabeth
E
Berezin
Vladimir
V
D000818:Animals; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008024:Ligands; D019006:Neural Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D017468:Receptors, Fibroblast Growth Factor / Q000819:agonists* / Q000737:chemistry / Q000378:metabolism
D008024:Ligands; D019006:Neural Cell Adhesion Molecules; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors