Antiapoptotic potential of herbal drugs in cardiovascular disorders: an overview.
Cardiomyocyte apoptosis has been reported in a number of cardiovascular disorders, including myocardial infarction, ischemia-reperfusion, end-stage heart failure, arrhythmogenic right ventricular dysplasia, and adriamycin-induced cardiomyopathy. Prevention of myocyte apoptosis has emerged as a potential new target in a multimodel therapeutic approach to cardiac disease. Herbal therapy may be an alternative strategy for the prevention and treatment of heart disease. The present review summarizes the list of plants/herbal formulations studied for their antiapoptotic activity in cardiovascular disorders. However, despite extensive positive research data from experimental studies for herbal drugs in cardiovascular disorders, and the anecdotal clinical experience of many practitioners and patients, its potential in the field of cardiac apoptosis remains largely untapped, and large scale clinical trials are needed to explore the potential of herbal medicines as a new treatment regime for targeting cardiovascular apoptosis.
Ahmad
Rahila
R
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India.
Javed
Saleem
S
Bhandari
Uma
U
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008517:Phytotherapy / Q000379:methods; D028321:Plant Preparations / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry / Q000145:classification
D028321:Plant Preparations