title: Does sodium thiosulphate delay presbyacusis?
abstract: BACKGROUND
  This study compares the effects of sodium thiosulphate (STS) and normal saline on the prevention of hearing loss.
  
  
  METHODS
  Animal research laboratory.
  
  
  METHODS
  Sixteen mice were randomized to receive intraperitoneal injections of either normal saline or STS. Auditory brainstem response testing was used to determine baseline and posttreatment hearing thresholds over the course of 1 year.
  
  
  RESULTS
  Compared with saline, treatment with STS resulted in a statistically significant improvement in click and pure-tone thresholds until the end of the year.
  
  
  CONCLUSIONS
  STS can significantly delay hearing loss associated with age in this murine model.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, Manitoba. taeed@shaw.ca
authors.forename: Taeed
authors.initials: T
authors.lastname: Quddusi
authors.forename: Brian W
authors.initials: BW
authors.lastname: Blakley
authors.forename: Eric
authors.initials: E
authors.lastname: Meen
authors.forename: Sylvie
authors.initials: S
authors.lastname: Berard
authors.forename: Zameel
authors.initials: Z
authors.lastname: Dewji
mesh_terms: D000818:Animals; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006309:Hearing / Q000502:physiology; D007274:Injections, Intraperitoneal; D051379:Mice; D008810:Mice, Inbred C57BL; D011304:Presbycusis / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D001557:Benzenesulfonates; C046836:thimerfonate