[Effect of liandou qingmai recipe on atherogenic indices of plasma and high-sensitivity C-reactive protein in patients with coronary heart disease].
OBJECTIVE
To observe the intervention effects of Liandou Qingmai Recipe (LQR) on atherogenic indices of plasma (AIP) and high-sensitivity c-reactive protein (hs-CRP) level in patients with coronary heart disease (CHD).


METHODS
Sixty-eight CHD patients were randomly assigned to two groups, 35 patients in the treatment group and 33 in the control group, all were treated by the regular CHD treatment, but to patients in the treatment group, LQR was given additionally. AIP value was calculated before and after treatment through measuring plasma levels of triglyceride (TG), high-density and low-density lipoprotein cholesterol (HDL-C and LDL-C). Besides, the levels of hs-CRP and peripheral blood leucocyte (PBL) were observed as well.


RESULTS
No significant difference existed between groups in all the detected parameters before treatment (P > 0.05). After treatment, levels of LDL-C, HDL-C, hs-CRP and PBL lowered significantly in the control group, but the changes of AIP and TG were insignificant (P > 0.05); while in the treatment group, all the parameters lowered significantly, with the levels of AIP, TG, hs-CRP and PBL significantly lower than those in the control group respectively (P < 0.05).


CONCLUSIONS
LQR can decrease levels of AlP and hs-CRP in CHD patients, amplify the diameters of LDL-C granule, and further lower hs-CRP and PLB levels, showing anti-atherosclerosis and anti-inflammation effects.
Zhu
Hong-jun
HJ
Department of Wuxi Cardiology, Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu. z7h6j@163.com
Lu
Shu
S
Su
Wei
W
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol