title: Kinetic isotope effects in asymmetric reactions.
abstract: Kinetic isotope effects are exquisitely sensitive probes of transition structure. As such, kinetic isotope effects offer a uniquely useful probe for the symmetry-breaking process that is inherent to stereoselective reactions. In this Concept article, we explore the role of steric and electronic effects in stereocontrol, and we relate these concepts to recent studies carried out in our laboratory. We also explore the way in which kinetic isotope effects serve as useful points of contact with computational models of transition structures. Finally, we discuss future opportunities for kinetic isotope effects to play a role in asymmetric catalyst development.
authors.affiliation: School of Natural Sciences, University of California, Merced, 5200 N. Lake Rd., Merced, CA 95344, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Giagou
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Meyer
mesh_terms: D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D039301:Computers, Molecular; D007554:Isotopes; D007700:Kinetics; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D001880:Boranes; D007554:Isotopes