title: Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis.
abstract: Trichomonas vaginalis, a human-infectious protozoan, can display resistance to treatment by metronidazole. A library of 3,4-dichloroaniline amides based on propanil, an herbicide, has been synthesized and screened to test susceptibility to these analogs. From this preliminary study, the most effective compound 15, inhibits growth of the organism by 66% and 69% on the two strains tested, T1 and G3, respectively.
authors.affiliation: Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA.
authors.forename: Padraick J
authors.initials: PJ
authors.lastname: Dornbush
authors.forename: Cynric
authors.initials: C
authors.lastname: Cho
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Chang
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.forename: Wade A
authors.initials: WA
authors.lastname: Russu
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Wrischnik
authors.forename: Kirkwood M
authors.initials: KM
authors.lastname: Land
mesh_terms: D000577:Amides / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000577:Amides; D000981:Antiprotozoal Agents