title: Ablation of atrial fibrillation at the time of cavotricuspid isthmus ablation in patients with atrial flutter without documented atrial fibrillation derives a better long-term benefit.
abstract: AF Ablation in Patients With Only Documentation of Atrial Flutter.
  
  
  OBJECTIVE
  The aim of the study was to evaluate whether isolation of the pulmonary veins (PVs) at the time of cavotricuspid isthmus (CTI) ablation is beneficial in patients with lone atrial flutter (AFL).
  
  
  BACKGROUND
  A high proportion of patients with lone persistent AFL have recurrent episodes of atrial fibrillation (AF) after CTI ablation. However, the benefit of AF ablation in patients with only documentation of AFL has not been determined.
  
  
  METHODS
  Forty-eight patients with typical lone persistent AFL (age 56 ± 6; 90% male) were randomized to CTI ablation (Group A; n = 25) or to CTI + PV isolation (PVI) (Group B; n = 23). In addition to PVI, some patients in group B underwent ablation of complex fractionated electrograms and/or creation of left atrial roof and mitral isthmus ablation line in a stepwise approach when AF was induced and sustained for more than 2 minutes. Mean follow-up was 16 ± 4 months with a 48-hour ambulatory monitor every 2 months.
  
  
  RESULTS
  There were no recurrences of AFL in either group. Six patients in group B (22%) underwent a stepwise ablation protocol. AF organized and terminated in 5 patients during ablation (83%). Complication rate was not significantly different among the groups. Twenty patients in group B (87%) and 11 patients in group A (44%) were free of arrhythmias on no medications at the end of follow-up (P < 0.05).
  
  
  CONCLUSIONS
  Ablation of AF at the time of CTI ablation results in a significantly better long-term freedom from arrhythmias.
authors.affiliation: Departments of Cardiology and Electrophysiology, Ball Memorial Hospital, Muncie, IN 47303, USA. annavarr@iupui.edu
authors.forename: Antonio
authors.initials: A
authors.lastname: Navarrete
authors.forename: Frank
authors.initials: F
authors.lastname: Conte
authors.forename: Michael
authors.initials: M
authors.lastname: Moran
authors.forename: Ishti
authors.initials: I
authors.lastname: Ali
authors.forename: Nathan
authors.initials: N
authors.lastname: Milikan
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000601:surgery*; D001282:Atrial Flutter / Q000453:epidemiology* / Q000601:surgery*; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D014261:Tricuspid Valve / Q000601:surgery*