title: Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum).
abstract: This case-series describes fourteen horses suspected of equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) also known as atypical myopathy of which seven cases were confirmed biochemically with all horses having had access to leaves of the Maple tree (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Assessment of organic acids, glycine conjugates, and acylcarnitines in urine was regarded as gold standard in the biochemical diagnosis of equine acquired multiple acyl-CoA dehydrogenase deficiency.
authors.affiliation: Department of Equine Sciences, Medicine Section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. j.h.vanderKolk@uu.nl
authors.forename: J H
authors.initials: JH
authors.lastname: van der Kolk
authors.forename: I D
authors.initials: ID
authors.lastname: Wijnberg
authors.forename: C M
authors.initials: CM
authors.lastname: Westermann
authors.forename: L
authors.initials: L
authors.lastname: Dorland
authors.forename: M G M
authors.initials: MG
authors.lastname: de Sain-van der Velden
authors.forename: L C
authors.initials: LC
authors.lastname: Kranenburg
authors.forename: M
authors.initials: M
authors.lastname: Duran
authors.forename: J A
authors.initials: JA
authors.lastname: Dijkstra
authors.forename: J J
authors.initials: JJ
authors.lastname: van der Lugt
authors.forename: R J A
authors.initials: RJ
authors.lastname: Wanders
authors.forename: E
authors.initials: E
authors.lastname: Gruys
mesh_terms: D031002:Acer; D000818:Animals; D001203:Ascomycota; D002264:Carboxylic Acids / Q000652:urine; D002331:Carnitine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005517:Foodborne Diseases / Q000662:veterinary*; D005998:Glycine / Q000652:urine; D006734:Horse Diseases / Q000201:enzymology* / Q000652:urine; D006736:Horses; D008297:Male; D054069:Multiple Acyl Coenzyme A Dehydrogenase Deficiency / Q000662:veterinary*; D010935:Plant Diseases / Q000382:microbiology; D018515:Plant Leaves
chemical_list: D002264:Carboxylic Acids; C116917:acylcarnitine; D002331:Carnitine; D005998:Glycine