title: Evaluating mitochondrial DNA in cancer occurrence and development.
abstract: Abnormal mitochondria have long been hypothesized to be involved in tumorigenesis. Mitochondrial DNA (mtDNA) mutations have been found in various cancer cells, yet their role in tumorigenesis remains largely unknown. Our long-term goal is to understand the role of mtDNA polymorphism and mtDNA mutations in tumorigenesis. We focused on the role of the mtDNA haplogroup; a 4,977 bp common mtDNA deletion; mtDNA mutations in the main control region of mtDNA or displacement loop; and mtDNA heteroplasmy in cancer occurrence and cancer development. Our results indicate that qualitative and quantitative changes in mtDNA play an important role in cancer development.
authors.affiliation: Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Shen
authors.forename: Hezhi
authors.initials: H
authors.lastname: Fang
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wei
authors.forename: Yijuan
authors.initials: Y
authors.lastname: Xin
authors.forename: Yulin
authors.initials: Y
authors.lastname: Jiang
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Ding
authors.forename: Jingzhang
authors.initials: J
authors.lastname: Ji
authors.forename: Jianxin
authors.initials: J
authors.lastname: Lu
authors.forename: Yidong
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000737:chemistry; D011110:Polymorphism, Genetic
chemical_list: D004272:DNA, Mitochondrial; D000255:Adenosine Triphosphate; D010100:Oxygen