A genotype and phenotype database of genetically modified malaria-parasites.
The RMgm database, www.pberghei.eu, is a web-based, manually curated, repository containing information on genetically modified rodent-malaria parasites. It provides easy and rapid access to information on the genotype and phenotype of mutant and reporter parasites. The database also contains information on unpublished mutants without a clear phenotype and negative trials to disrupt genes. Information can be searched using pre-defined key features, such as phenotype, life-cycle stage, gene model, gene-tags and mutations. The information relating to the mutants is reciprocally linked to PlasmoDB and GeneDB. Access to mutant-parasite information, and gene function/ontology inferred from mutant phenotypes provides a timely resource aimed at enhancing research into Plasmodium gene function and (systems) biology.
Janse
Chris J
CJ
Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre (LUMC), Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. c.j.janse@lumc.nl
Kroeze
Hans
H
van Wigcheren
Auke
A
Mededovic
Senad
S
Fonager
Jannik
J
Franke-Fayard
Blandine
B
Waters
Andrew P
AP
Khan
Shahid M
SM
D000818:Animals; D030541:Databases, Genetic; D004195:Disease Models, Animal; D005838:Genotype; D008288:Malaria / Q000469:parasitology; D009154:Mutation / Q000235:genetics; D030781:Organisms, Genetically Modified; D010641:Phenotype; D010961:Plasmodium / Q000235:genetics*