Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects.
Calcium phosphate glass (CPG) is well-documented alloplastic bone graft material. The objective of this study was to evaluate the osteoconductive effect of newly developed calcium phosphate glass cement (CPGC) in rabbit calvarial defects. Three circular defects (8 mm diameter) were created on the rabbit calvarium. One defect was filled with biphasic calcium phosphate (BCP group) and one defect was filled with CPGC (CPGC group). The remaining defect was not filled as the control. Histologic and histometric analysis were performed at four and eight weeks following the implantation of materials. One-way ANOVA method was used to evaluated the significance between three groups (p < 0.05). The CPGC group did not show a statistical difference in new bone area compared with the control at all healing periods, but the bone formation rate of CPGC seemed to increase between four and eight weeks. This suggests the bone formation rate of CPGC is initially slow, but increases at a specific time, showing the possibility of greater bone formation with time. The resorption rate of CPGC was greater than BCP. Within the limits of this study, CPGC demonstrated good space maintaining capacity and had an osteoconductive effect, suggesting it could be successfully used to improve bone formation capacity.
Lim
Hyun-Chang
HC
Department of Periodontology, Research Institute for Periodontal Regeneration College of Dentistry, Yonsei University, Seoul 120-752, Korea.
Sohn
Joo-Yeon
JY
Park
Jung-Chul
JC
Um
Yoo-Jung
YJ
Jung
Ui-Won
UW
Kim
Chang-Sung
CS
Lee
Yong-Keun
YK
Choi
Seong-Ho
SH
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D001862:Bone Resorption; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000494:pharmacology*; D005898:Glass; D007700:Kinetics; D010012:Osteogenesis; D011817:Rabbits; D012886:Skull / Q000293:injuries*
D018786:Bone Substitutes; D002130:Calcium Phosphates