title: [Impact of growth-factor hormone control on the outcome of acromegalic cardiomyopathy].
abstract: OBJECTIVE
  To observe the impact of growth-factor hormone control on the outcome of acromegalic cardiomyopathy by reviewing cases from our own center and from literatures.
  
  
  METHODS
  Two cases of acromegalic cardiomyopathy from Tongji hospital and 29 acromegalic cardiomyopathy cases with fully accessible data retrieved from PubMed and CNKI websites were included in present study for analysis. They were divided into "Controlled (< 5 microg/L)" or "Uncontrolled" group according to the serum level of growth factor hormone after treatments. Outcome of patients was evaluated by symptom, NYHA class, LV size and function status.
  
  
  RESULTS
  Incidence of patients with improved symptoms and cardiac performance was significantly higher in "Controlled" group (18/19) compared to those in "Uncontrolled" group (0/12; P < 0.01, chi(2) = 27.1). Post-treatment growth-factor hormone level < 5 microg/L is significantly associated with a satisfactory outcome of acromegalic cardiomyopathy (r = 0.935, P < 0.01).
  
  
  CONCLUSIONS
  Control of serum growth-factor concentration to a value < 5 microg/L is critical and associated with a favorable outcome for patients with acromegalic cardiomyopathy.
authors.affiliation: Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Qiu-fang
authors.initials: QF
authors.lastname: She
authors.forename: Rong
authors.initials: R
authors.lastname: Bai
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.forename: Jiang-tao
authors.initials: JT
authors.lastname: Yan
authors.forename: Dao-wen
authors.initials: DW
authors.lastname: Wang
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000628:therapy*; D000369:Aged, 80 and over; D009202:Cardiomyopathies / Q000209:etiology / Q000628:therapy*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone