title: Thrombotic microangiopathy and the antiphospholipid syndrome.
abstract: The antiphospholipid syndrome (APS) comprises the association between vascular thrombosis, including microthrombosis, pregnancy morbidity and the coexistence of anti-phospholipid antibodies. Thrombotic microangiopathy (TMA) can be one of the manifestations of the APS and may involve any organ. This feature of the APS is probably less recognized by clinical doctors than venous thrombosis and recurrent abortions. This case report presents a patient who developed a widespread TMA with renal failure, gastric mucosa ulceration, urinary bladder ulcerations and a finger necrosis as part of the APS.
authors.affiliation: Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Norway. josj@sus.no
authors.forename: S J A
authors.initials: SJ
authors.lastname: Johnsen
authors.forename: T
authors.initials: T
authors.lastname: Valborgland
authors.forename: E
authors.initials: E
authors.lastname: Gudlaugsson
authors.forename: L
authors.initials: L
authors.lastname: Bostad
authors.forename: R
authors.initials: R
authors.lastname: Omdal
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005385:Fingers / Q000473:pathology; D006801:Humans; D009336:Necrosis; D051437:Renal Insufficiency / Q000209:etiology / Q000473:pathology; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology; D057049:Thrombotic Microangiopathies / Q000209:etiology* / Q000473:pathology; D001745:Urinary Bladder Diseases / Q000209:etiology / Q000473:pathology