[Coagulation disorders after traumatic brain injury: pathophysiology and therapeutic implications].
Early activation of coagulation is common after traumatic brain injury. Its origin is probably mainly intracerebral, due to tissue factor release from the injured brain. Abnormalities in blood coagulation tests are associated with poor neurological prognosis. Coagulation activation may induce disseminated intravascular coagulation and fibrinolysis. Disseminated intravascular coagulation is linked to brain ischemia caused by intravascular microthrombosis. This review will focus on pathophysiology of coagulation disorders after traumatic brain injury, and on their implications for therapeutic approaches.
Geeraerts
T
T
Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, AP-HP, faculté de médecine, université Paris Sud, 78 rue du Général-Leclerc, Le-Kremlin-Bicêtre, France. geeraerts.t@chu-toulouse.fr
Haïk
W
W
Tremey
B
B
Duranteau
J
J
Vigué
B
B
D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D001930:Brain Injuries / Q000150:complications* / Q000503:physiopathology; D006801:Humans