title: [A case of advanced gastric cancer growing extramurally with gynecomastia and high hCG-beta serum level].
abstract: We describe a rare case of advanced gastric cancer with markedly high serum levels of human chorionic gonadotrophin beta subunit (hCG-beta). The patient was a 51-year-old man admitted for a gastric tumor growing extramurally and multiple liver tumors revealed by computed tomography, with chief complaints of abdominal and breast mass. Upper gastrointestinal endoscopy showed gastric cancer of Borrmann type 2 and biopsy specimens showed poorly-differentiated adenocarcinoma. The serum levels of hCG/beta was very high (21, 551. 6 mIU/mL). Pathological examination from liver tumor showed the tumor cells greatly resembled gastric tumor and were immunohistochemically positive for hCG-beta. We diagnosed hCG-beta producing gastric cancer. He received chemotherapy, but died of hepatic failure about 8 months after initial diagnosis. When we see a patient with gynecomastia and the high serum hCG-beta levels, it is important that hCG-beta producing-gastric cancer should be considered as a possible malignant tumor of the stomach.
authors.affiliation: Hamamatsu South Hospital Center for Gastroenterology & IBD Research.
authors.forename: Osamu
authors.initials: O
authors.lastname: Arai
authors.forename: Akira
authors.initials: A
authors.lastname: Kakutani
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Mouri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Kenji
authors.initials: K
authors.lastname: Notohara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsueda
mesh_terms: D001706:Biopsy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D017809:Fatal Outcome; D006177:Gynecomastia / Q000097:blood* / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human