title: Effect of intracameral epinephrine use on macular thickness after uneventful phacoemulsification.
abstract: OBJECTIVE
  To evaluate changes in central macular thickness using optical coherence tomography after uneventful cataract surgery combined with intracameral epinephrine use.
  
  
  METHODS
  Beyoğlu Eye Training and Research Hospital, Istanbul, Turkey.
  
  
  METHODS
  This prospective case series comprised eyes of consecutive patients who had uneventful phacoemulsification and in-the-bag intraocular lens (IOL) implantation between August 2005 and January 2006. The eyes were randomly assigned to 1 of 2 groups. In 1 group, 0.2 mL epinephrine (1:5000 solution) was injected just after the clear corneal incision was created. The other group (control) did not receive epinephrine. Optical coherence tomography was performed in all eyes preoperatively as well as postoperatively at 1 day, 1 week, and 1, 3, and 6 months.
  
  
  RESULTS
  The epinephrine group comprised 73 eyes (73 patients) and the control group, 76 eyes (86 patients). In both groups, the increase in retinal thickness from preoperatively to 1, 3, and 6 months postoperatively was statistically significant (P<.05); the difference was not statistically significant at 1 day or 1 week in either group (P>.05). There were no statistically significant differences between the 2 groups in mean retinal thickness throughout the follow-up (P>.05). Clinically significant macular edema occurred in 3 eyes in the epinephrine group and 3 eyes in the control group.
  
  
  CONCLUSIONS
  Although epinephrine is a well-known risk factor for central macular edema, intracameral injection of 0.2 mL epinephrine (1:5000) did not increase the risk for central macular edema in eyes with no risk factors that had uneventful phacoemulsification with IOL implantation.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: Beyoğlu Eye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ercument
authors.initials: E
authors.lastname: Bozkurt
authors.forename: Ahmet Taylan
authors.initials: AT
authors.lastname: Yazici
authors.forename: Gökhan
authors.initials: G
authors.lastname: Pekel
authors.forename: Sinan
authors.initials: S
authors.lastname: Albayrak
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cakir
authors.forename: Evre
authors.initials: E
authors.lastname: Pekel
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000187:drug effects*; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D019654:Lens Implantation, Intraocular; D008266:Macula Lutea / Q000187:drug effects / Q000473:pathology*; D008269:Macular Edema / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage*; D018918:Phacoemulsification; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects*; D041623:Tomography, Optical Coherence
chemical_list: D009184:Mydriatics; D004837:Epinephrine