Evaluation of melatonin on the precocious puberty: a pilot study.
OBJECTIVE
To evaluate the effect of 6-sulphatoxymelatonin on the sleep quality of girls with precocious puberty.


METHODS
Ninety-nine girls were divided into three groups: GI, precocious puberty; GII, normal prepubescent; GIII, normal puberty. Questionnaires containing demographic and clinical data were applied. Blood was collected for hormonal evaluation for 6-sulphatoxymelatonin. The modified Rush Sleep Diary was used.


RESULTS
The levels of 6-sulphatoxymelatonin were highest in the group without pubertal development (75.23 ± 10.84 ng/ml), second highest in the group with normal puberty (45.66 ± 3.87 ng/ml, p < 0.001) and lowest in the group with true precocious puberty (37.04 ± 5.47 ng/ml). The amount of day sleep was greater in the group without pubertal development compared to other groups.


CONCLUSIONS
Despite the sleep data, melatonin may be involved in the precocious puberty process.
de Holanda
Felisbela Soares
FS
Divisão de Ginecologia da Infância e Adolescência, Department of Gynecology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
Tufik
Sérgio
S
Bignotto
Magda
M
Maganhin
Carla G
CG
Vieira
Lucia Helena Laprano
LH
Baracat
Edmund C
EC
Soares
José Maria
JM
D002648:Child; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D010865:Pilot Projects; D010907:Pituitary Hormones / Q000097:blood; D011629:Puberty, Precocious / Q000097:blood / Q000503:physiopathology / Q000652:urine*; D012893:Sleep Wake Disorders / Q000209:etiology; D011795:Surveys and Questionnaires
D012739:Gonadal Steroid Hormones; D010907:Pituitary Hormones; C054513:6-sulfatoxymelatonin; D008550:Melatonin