Enantioselective synthesis of SSR 241586 by using an organo-catalyzed Henry reaction.
An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).
Cochi
Anne
A
Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Métro
Thomas-Xavier
TX
Pardo
Domingo Gomez
DG
Cossy
Janine
J
D002384:Catalysis; D004952:Esters; D043183:Irritable Bowel Syndrome / Q000188:drug therapy*; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
D004952:Esters; D009025:Morpholines; C553354:SSR 241586