title: CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer.
abstract: Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR=5.14; 95% CI=0.94-28.23) but the observed association was non-significant (p=0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.
authors.affiliation: Toxicogenomics Unit, National Institute of Public Health, Srobarova 48, 100 42, Prague 10, Czech Republic.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Mohelnikova-Duchonova
authors.forename: Ondrej
authors.initials: O
authors.lastname: Havranek
authors.forename: Ivona
authors.initials: I
authors.lastname: Hlavata
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Kleibl
authors.forename: Petr
authors.initials: P
authors.lastname: Pohlreich
authors.forename: Pavel
authors.initials: P
authors.lastname: Soucek
mesh_terms: D016022:Case-Control Studies; D064447:Checkpoint Kinase 2; D018153:Czech Republic / Q000453:epidemiology; D005091:Exons; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017434:Protein Structure, Tertiary; D017384:Sequence Deletion
chemical_list: D064447:Checkpoint Kinase 2; C578634:CHEK2 protein, human; D017346:Protein Serine-Threonine Kinases