Evaluation of nonenhancing tumor fraction assessed by dynamic contrast-enhanced MRI subtraction as a predictor of decrease in tumor volume in response to chemoradiotherapy in advanced cervical cancer.
OBJECTIVE
In this study, we evaluated the feasibility of using dynamic contrast-enhanced MRI (DCE-MRI) subtracted images as a predictor of a decrease in tumor volume in response to chemoradiotherapy in 13 patients with cervical cancer.


CONCLUSIONS
This study shows that pretreatment tumor nonenhancing fraction assessed with arterial image subtraction inversely predicts the chemoradiation response in cervical cancer.
Mannelli
Lorenzo
L
Department of Radiology and Cambridge University Hospitals NHS Trust, Addenbrooke's Hospital, United Kingdom. lorenzo.mannelli@nyumc.org
Patterson
Andrew J
AJ
Zahra
Mark
M
Priest
Andrew N
AN
Graves
Martin J
MJ
Lomas
David J
DJ
Tan
Li Tee
LT
Crawford
Robin
R
Brenton
James
J
Sala
Evis
E
D000328:Adult; D017024:Chemotherapy, Adjuvant; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D055815:Young Adult
D003287:Contrast Media; D019786:Gadolinium DTPA