title: The association of -262C/T polymorphism in the catalase gene and delayed graft function of kidney allografts.
abstract: BACKGROUND
  Catalase is an intracellular antioxidant enzyme that is mainly located in cellular peroxisomes and in the cytosol. This enzyme plays a significant role in the development of tolerance to oxidative stress in the adaptive response of cells and tissues. The aim of the present study was to examine the association between the -262C/T polymorphism in the catalase gene and delayed graft function (DGF), acute rejection and chronic allograft nephropathy of kidney allografts.
  
  
  METHODS
  One hundred eighty-seven recipients of first renal transplants were included in the study. The histories of the patients were analysed regarding DGF, acute rejection and chronic allograft nephropathy. The polymorphism -262C/T in the catalase gene was analysed using the polymerase chain reaction--restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  The risk of DGF was significantly lower in T allele carriers compared with CC homozygotes: odds ratio = 0.34, 95% confidence interval = 0.17-0.67, P = 0.001. There were no statistically significant associations between the studied polymorphism and acute rejection or chronic allograft nephropathy.
  
  
  CONCLUSIONS
  The results of this study suggest that -262C/T polymorphism in the catalase gene is associated with DGF in kidney allograft recipients.
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Dutkiewicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Domanski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Binczak-Kuleta
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002374:Catalase / Q000235:genetics*; D051799:Delayed Graft Function / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000201:enzymology / Q000235:genetics; D006085:Graft Survival / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018570:Risk Assessment; D012307:Risk Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002374:Catalase