Antimicrobial activity of simulated solar disinfection against bacterial, fungal, and protozoan pathogens and its enhancement by riboflavin.
Riboflavin significantly enhanced the efficacy of simulated solar disinfection (SODIS) at 150 watts per square meter (W m(-2)) against a variety of microorganisms, including Escherichia coli, Fusarium solani, Candida albicans, and Acanthamoeba polyphaga trophozoites (>3 to 4 log(10) after 2 to 6 h; P < 0.001). With A. polyphaga cysts, the kill (3.5 log(10) after 6 h) was obtained only in the presence of riboflavin and 250 W m(-2) irradiance.
Heaselgrave
Wayne
W
Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, P.O. Box 138, University Road, Leicester LE1 9HN, United Kingdom. wh12@le.ac.uk
Kilvington
Simon
S
D000048:Acanthamoeba / Q000187:drug effects* / Q000528:radiation effects*; D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000528:radiation effects; D004202:Disinfectants / Q000494:pharmacology; D004203:Disinfection / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects* / Q000528:radiation effects*; D005658:Fungi / Q000187:drug effects* / Q000528:radiation effects*; D005670:Fusarium / Q000187:drug effects / Q000528:radiation effects; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D012256:Riboflavin / Q000494:pharmacology*; D014466:Ultraviolet Rays
D004202:Disinfectants; D012256:Riboflavin