Long-term remission after successful pregnancy in autologous peripheral blood stem cell transplanted system lupus erythematosus patients.
Pregnancies in systemic lupus erythematosus (SLE) patients are high risk to both mother and fetus because of increased rates of complications. During the past years, we have treated many cases of SLE patients using autologous peripheral blood stem cell transplantation with good outcome after pregnancy. The rate of maternal hypertension and lupus nephritis was greatly reduced in autologous peripheral blood stem cell transplanted group (n = 11) when compared to non-transplant group (n = 39) (P < 0.05). In addition, the outcome of lupus flare activity of the mother after delivery is significantly better in transplanted group than that in non-transplanted group (P < 0.05). Here, we describe two typical cases of long duration (>6 years) of remission after successful pregnancy in refractory SLE patients post-autologous peripheral blood stem cell transplantation. Our report demonstrated that peripheral blood stem cell transplantation is safe and effective, thereby could be recommended as prior strategy in refractory SLE patients, especially for those women of child-bearing age who plan for pregnancy.
Meng
Jianbo
J
Department of Hematology, Hebei Medical University Third Hospital, Hebei, China. mjb1972@tom.com
Wang
Jinkai
J
Liang
Wenjie
W
Qin
Shan
S
Wu
Chuntao
C
D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D050498:Live Birth; D008180:Lupus Erythematosus, Systemic / Q000601:surgery*; D036102:Peripheral Blood Stem Cell Transplantation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D012074:Remission Induction; D055502:Secondary Prevention; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D007166:Immunosuppressive Agents