title: Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma.
abstract: BACKGROUND
  This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC).
  
  
  METHODS
  A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clusters showed immunoreactivity to vimentin, whereas vimentin-negative expression was defined as no detectable expression.
  
  
  RESULTS
  Of the 21 patients, 5 were classified as having tumours with vimentin-positive expression and 16 with vimentin-negative expression. Vimentin-positive expression was more frequent in tumour specimens that were poorly differentiated (4/7; 57%) than in those that were well- or moderately differentiated (1/14; 7%, p=0.025) and was always seen in areas with the highest histological grade. Vimentin-positive expression affected survival adversely, according to univariate (p=0.010) and multivariate analyses (relative risk, 4.294; p=0.047).
  
  
  CONCLUSIONS
  Vimentin-positive expression correlates with dedifferentiation and predicts poor survival in patients undergoing resection for ICC.
authors.affiliation: Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
authors.forename: Pavel V
authors.initials: PV
authors.lastname: Korita
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Wakai
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ajioka
authors.forename: Makoto
authors.initials: M
authors.lastname: Inoue
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Shirai
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Hatakeyama
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D002454:Cell Differentiation; D018281:Cholangiocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D014746:Vimentin / Q000032:analysis / Q000502:physiology*
chemical_list: D014746:Vimentin