[Motor protein Kinesin-6 and ischemic heart disease].
The review describes possible role of kinesins in development of coronary heart disease and efficacy of treatment with statins. Fourty five kinesins are represented in human body making up a superfamily of universal and simplest motor proteins which are expressed almost in all tissues. Level of kinesin 6 is 5% higher than expression of other kinesins in some segments of coronary arteries and it is relatively low in organs playing unknown role in susceptibility to atherosclerosis. As a result of several genoms wide association studies the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins was revealed.
Koroleva
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Zateĭshchikov
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DA
D000368:Aged; D000483:Alleles; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D016547:Kinesins / Q000737:chemistry / Q000502:physiology; D050356:Lipid Metabolism / Q000187:drug effects / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020409:Molecular Motor Proteins / Q000502:physiology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012441:Saccharomyces cerevisiae / Q000235:genetics
D005819:Genetic Markers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020409:Molecular Motor Proteins; C526774:KIF6 protein, human; D016547:Kinesins