A skeleton in the closet: neogenin guides bone development.
Bone Morphogenetic Proteins (BMPs) are key regulators of skeletal development. In this issue of Developmental Cell, Zhou et al. show that neogenin, a receptor for neuronal axon guidance, also regulates endochondral bone formation and BMP signaling and does so by influencing BMP receptor localization in membrane microdomains.
Podkowa
Monika
M
Department of Biochemistry, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.
Attisano
Liliana
L