title: Effect of dietary high molybdenum on peripheral blood T-cell subsets and serum IL-2 contents in broilers.
abstract: The objectives of this study were to investigate the effects of dietary high molybdenum (Mo) on immune function by determining changes of the subsets of peripheral blood T-cells and serum interleukin (IL)-2 contents. 300 1-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same diet amended to contain 500; 1,000; and 1,500 mg/kg of Mo supplied as sodium molybdate dihydrate. In comparison with those of the control group, the percentages of CD3(+), CD3(+)CD4(+) and CD3(+)CD8(+) were decreased in 1,000 and 1,500 mg/kg of Mo intake groups from 14 days of age to 42 days of age. Also, the serum IL-2 contents were decreased in 1,000 and 1,500 mg/kg of Mo intake groups from 14 days of age to 42 days of age. Histopathologically, hypocellularity appeared in the thymus in 1,000 and 1,500 mg/kg of Mo intake groups. It was concluded that dietary high-Mo (1,000 mg/kg and 1,500 mg/kg) reduced the percentages of peripheral blood T-cell subsets and serum IL-2 contents and caused thymic lesions. The cellular immune function was finally injured in broilers.
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.forename: Hengmin
authors.initials: H
authors.lastname: Cui
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Xi
authors.initials: X
authors.lastname: Peng
authors.forename: Yun
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D002645:Chickens / Q000276:immunology; D005434:Flow Cytometry; D007376:Interleukin-2 / Q000097:blood*; D008982:Molybdenum / Q000008:administration & dosage / Q000494:pharmacology*; D016176:T-Lymphocyte Subsets / Q000187:drug effects*
chemical_list: D007376:Interleukin-2; D008982:Molybdenum; C024687:sodium molybdate(VI)