title: [Resected pleomorphic carcinoma after long-time follow-up].
abstract: We report a case of surgical resection of a pulmonary pleomorphic carcinoma after 6 years follow-up. A 75-year-old male patient was referred to our department for an irregular shadow (32 x 17 mm) in the left upper lung lobe. Chest computed tomography (CT) conducted 6 years before showed an 8 x 5 mm nodule in the same location; after 3 years prior the nodule had a thin wall cavity, and 2 years ago a new nodule was observed within the cavity. The nodule and cavity had been growing gradually as shown by chest CT. The patient underwent wedge resection of the left lung without any adjuvant therapy because of poor physical condition due to right hemiplegia, old myocardial infarction, aortic stenosis, and a poor status after esophageal and colon cancer resection. Histopathology of the resected specimen revealed that the nodule contained a component with spindle cell features while the parenchymal side of the cavity was composed of bronchioalveolar carcinoma (BAC). Immunohistochemistry showed that the adenocarcinoma was positive for AE1/AE3 and thyroid transcription factor (TTF)-1, while the spindle cells were positive for AE1/AE3, with only a small portion being positive for TTF-1. The final diagnosis was pleomorphic carcinoma. His postoperative course has been uneventful over the 4 months since surgery.
authors.affiliation: Department of Cardiothoracic Surgery, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sano
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukami
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Murakawa
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006651:Histocytochemistry; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D014057:Tomography, X-Ray Computed