[Effect of 1-tetrahydropalmatine on spontaneous electric discharge induced by chronic dorsal root ganglion neurons compression in rats].
OBJECTIVE
To study the effect of 1-tetrahydropalmatine (1-THP) on the spontaneous electric discharge (SED) induced by chronic dorsal root ganglion neurons compression.


METHODS
Using single fiber recording method, the SED of 84 neurons class A induced by compression were recorded. The effect of 1-THP on the SEDs and its relation with concentration were observed.


RESULTS
In the 84 SED of neurons, 25 showed periodical rhythmicity (PR) and 59 showed non-periodic rhythmicity (non-PR). 1-THP (100 micromol/L) inhibited SED in 16.0% (4/25) of neurons with PR and 67.8% (40/59) of neurons with non-PR (P < 0.01) in an effect-dose dependent manner, the higher the concentration of 1-THP, the more the inhibition, with quicker inhibiting in initiation and longer time needed for recovery. SED in 57.1% neurons were recovered 20 min after elution, but unrecovered even after 3 h in the others.


CONCLUSIONS
1-THP shows inhibitory effect on the A-fiber SED induced by chronic dorsal root ganglion neurons compression.
Du
Lan-fang
LF
Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an.
Du
Yong-ping
YP
Xu
Hui
H
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001600:Berberine Alkaloids / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000293:injuries / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D001600:Berberine Alkaloids; C014215:tetrahydropalmatine