[Newest research progress in hypoxia genetic adaptation to high altitude].
The genetic adaptation of Plateau residents to hypoxia of low-pressure has been the hot spot for study. In terms of physiology, the adaptation involves the regulation responses of blood vessels, the changes in blood cells, antioxidant capacity and energy metabolism, as well as the hypoxia-induced changes in nuclear transcription. Physiological adaptation is heritable, so people who have already adapted themselves to high altitude are bound to be different, in regard to gene level, from the crowd who have not yet adapted themselves to high altitude environment. For this reason, researchers have studied a great deal of gene related-enzymes, the receptors, polypeptide, as well as transcription factors in body, and they found a number of the DNA polymorphism sites in the people who have adapted themsevles to high altitude being different from those in the people who do not get acclimatized. In this paper is reviewed the newest advance in research of these gene polymorphisms. The data could serve as references for further study of hypoxia genetic adaptation to high altitude.
Zhou
Futao
F
College of Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Sun
Xuechuan
X
D000064:Acclimatization / Q000235:genetics*; D000222:Adaptation, Physiological / Q000235:genetics; D000531:Altitude; D006801:Humans; D000860:Hypoxia / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*