Structure of single-wall peptide nanotubes: in situ flow aligning X-ray diffraction.
The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A(6)K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into beta-sheet ribbons that wrap helically to form the nanotube wall.
Castelletto
Valeria
V
Dept of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK.
Nutt
David R
DR
Hamley
Ian W
IW
Bucak
Seyda
S
Cenker
Celen
C
Olsson
Ulf
U
D018360:Crystallography, X-Ray; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D045333:Nanotubes, Peptide / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation
D045333:Nanotubes, Peptide; D009842:Oligopeptides; C508692:acetyl-alanyl-alanyl-alanyl-alanyl-alanyl-alanyl-lysine