title: Periodontal therapy and low birth weight: preliminary results from an alternative methodologic strategy.
abstract: BACKGROUND
  The purpose of this study is to present the use of a non-randomized experimental design with multiple controls, with emphasis on a historical control group, as an alternative methodologic resource for studies on the association between periodontal disease and prematurity/low birth weight.
  
  
  METHODS
  The sample consisted of 234 pregnant women: 54 in the Test Group (treatment of periodontal disease); 68 in Control Group I (without periodontal disease); and 112 in Control Group II (historical control group, with untreated periodontal disease). The diagnosis of periodontal disease was established by means of a complete clinical examination, using measurements of probing depth, gingival recession, clinical attachment loss, and bleeding index. The women in the Test Group were treated for periodontitis and followed-up with periodontal support therapy throughout their pregnancies. After delivery, they were reevaluated regarding their periodontal condition, and information on the newborn's birth weight was obtained. This was also done for Control Groups I and II. Descriptive analyses on the study variables were performed using the χ(2) and Fisher exact tests. Association measurements (relative risk) were obtained using a significance level of 5%.
  
  
  RESULTS
  The frequency of low birth weight among the Test Group was similar to Control Group I and lower than Control Group II.
  
  
  CONCLUSIONS
  The results suggest that successful periodontal therapy in pregnant women suffering from periodontitis is a protective factor promoting the birth of children with normal weight.
authors.affiliation: Department of Health, Feira de Santana State University, Bahia, Brazil. isuzart@gmail.com
authors.forename: Isaac S
authors.initials: IS
authors.lastname: Gomes-Filho
authors.forename: Simone S
authors.initials: SS
authors.lastname: Cruz
authors.forename: Maria da Conceiçao N
authors.initials: Mda C
authors.lastname: Costa
authors.forename: Johelle S
authors.initials: JS
authors.lastname: Passos
authors.forename: Eneida M M
authors.initials: EM
authors.lastname: Cerqueira
authors.forename: Fábio P
authors.initials: FP
authors.lastname: Sampaio
authors.forename: Eliesita C
authors.initials: EC
authors.lastname: Pereira
authors.forename: Lituânia F
authors.initials: LF
authors.lastname: Miranda
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D015992:Body Mass Index; D004245:DMF Index; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000628:therapy; D005889:Gingival Recession / Q000628:therapy; D020073:Gravidity; D006801:Humans; D007182:Income; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D017533:Marital Status; D017622:Periodontal Attachment Loss / Q000628:therapy; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011295:Prenatal Care; D012907:Smoking; D055815:Young Adult