title: FMRI correlates of apraxia in Parkinson's disease patients OFF medication.
abstract: Impairment of hand dexterity in Parkinson's disease (PD) is usually attributed to bradykinesia. Recently, behavioral studies illustrated that decreased dexterity might also be due to limb-kinetic apraxia (LkA), as demonstrated by impaired performance in a coin rotation task. Here, we provide a first investigation on whether functional magnetic resonance imaging (fMRI) may reveal specific brain activation patterns for PD patients with impaired performance in a coin rotation task. We compared coin rotation as an apraxia task to simple finger tapping as a bradykinesia task in ten PD patients OFF medication and matched healthy controls. In addition to a tendency for general overactivation, PD patients showed a perirolandic dissociation with precentral overactivation and postcentral underactivation. This finding significantly separated PD patients from healthy controls.
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria. thomas.foki@meduniwien.ac.at
authors.forename: T
authors.initials: T
authors.lastname: Foki
authors.forename: W
authors.initials: W
authors.lastname: Pirker
authors.forename: N
authors.initials: N
authors.lastname: Klinger
authors.forename: A
authors.initials: A
authors.lastname: Geissler
authors.forename: J
authors.initials: J
authors.lastname: Rath
authors.forename: T
authors.initials: T
authors.lastname: Steinkellner
authors.forename: I
authors.initials: I
authors.lastname: Hoellinger
authors.forename: S
authors.initials: S
authors.lastname: Gruber
authors.forename: D
authors.initials: D
authors.lastname: Haubenberger
authors.forename: J
authors.initials: J
authors.lastname: Lehrner
authors.forename: G
authors.initials: G
authors.lastname: Pusswald
authors.forename: S
authors.initials: S
authors.lastname: Trattnig
authors.forename: E
authors.initials: E
authors.lastname: Auff
authors.forename: R
authors.initials: R
authors.lastname: Beisteiner
mesh_terms: D000368:Aged; D001072:Apraxias / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology