A facile one-pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones.
One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl(3) has been developed. The structures of all the title compounds have been confirmed by IR, (1)H-NMR, (13)CNMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.
Zhang
Xiaohong
X
College of Chemistry and Materials Engineering, Wenzhou Universtity, Wenzhou 325035, China. kamenzxh@163.com
Lin
Qiulian
Q
Zhong
Ping
P
D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
D009570:Nitriles; D011743:Pyrimidines