title: Successful treatment of combination therapy with tacalcitol lotion associated with sunscreen for localized Darier's disease.
abstract: We herein report a sporadic case of Darier's disease localized to the bilateral side of the neck in a 39-year-old Japanese woman. Several clinical variants of Darier's disease have so far been recognized including unilateral Darier's disease, localized Darier's disease, segmental Darier's disease and acral Darier's disease. Few cases of Darier's disease, restricted to sun-exposed areas such as the bilateral side of the neck, have been described in the published work. It remains controversial, however, whether ultraviolet exposure can induce the onset of Darier's disease. Our patient's skin lesions, which were resistant to previous treatment with corticosteroid, improved substantially with high-concentration tacalcitol lotion and sunscreen. This is the first report on the efficacy of topical tacalcitol lotion associated with sunscreen for the treatment of localized Darier's disease.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan. masaabe@med.gunma-u.ac.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Abe
authors.forename: Masato
authors.initials: M
authors.lastname: Yasuda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D007644:Darier Disease / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000235:genetics; D013472:Sunlight / Q000009:adverse effects; D013473:Sunscreening Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D004100:Dihydroxycholecalciferols; D013473:Sunscreening Agents; C023850:1 alpha,24-dihydroxyvitamin D3; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human