Determination of Imazaquin and its metabolite by liquid chromatography-quadrupole-time of flight tandem mass.
A method consisting of solvent extraction followed by liquid chromatography-quadrupole-time of flight- tandem mass spectrometry analysis was developed for the identification of Imazaquin and its metabolite. The relationships between detector response and sample concentrations showed a high degree of linearity (r > 0.998) over the range 0.03-10 microg/g. The recoveries obtained were in the acceptable range of 86%-104% between spiked. The relative standard deviation of this method was 6.4%-17.1%. A 35-day study of Imazaquin degradation was taken in agricultural soil from Binzhou, China. The degradation followed first order kinetics (C = 0.7672e(-0.0774t)), with half-life of less than 8.5 days. Investigation of the by-products from liquid chromatography-quadrupole-time of flight- tandem mass spectrometry has shown that there were four important metabolites 4-methylene-2-(quinolin-2-yl)-1H-imidazol-5(4H)-one, quinoline-3-carbaldehyde, 1-amino-2,3-dimethyl-1-oxobutan-2-ylium and 1H-[1,2]oxazino[4,5-b]quinolin-1-one in the degradation process. The accurate mass measurements error was 5 ppm in this study. The method was successfully applied to the analysis of imazaquin and its metabolite residues in soil.
Yao
H B
HB
Department of Chemistry and Chemical Engineering, Binzhou University, Binzhou, Shandong, China. yyhs1981@163.com
Han
G J
GJ
Liu
G X
GX
Xie
Y
Y
Wang
C H
CH
D000383:Agriculture; D002681:China; D002851:Chromatography, High Pressure Liquid; D004784:Environmental Monitoring; D007093:Imidazoles / Q000032:analysis* / Q000378:metabolism; D010573:Pesticide Residues / Q000032:analysis* / Q000378:metabolism; D011804:Quinolines / Q000032:analysis* / Q000378:metabolism; D012987:Soil / Q000032:analysis; D012989:Soil Pollutants / Q000032:analysis* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization
D007093:Imidazoles; D010573:Pesticide Residues; D011804:Quinolines; D012987:Soil; D012989:Soil Pollutants; C057728:imazaquin