Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis.
Post-streptococcal acute glomerulonephritis (PSAGN) is one of the most important and intriguing conditions in the discipline of pediatric nephrology. Although the eventual outcome is excellent in most cases, PSAGN remains an important cause of acute renal failure and hospitalization for children in both developed and underdeveloped areas. The purpose of this review is to describe both the typical and less common clinical features of PSAGN, to outline the changes in the epidemiology of PSAGN over the past 50 years, and to explore studies on the pathogenesis of the condition with an emphasis on the search for the elusive nephritogenic antigen.
Eison
T Matthew
TM
Division of Pediatric Nephrology, Department of Pediatrics, University of Tennessee Health Science Center, and Children's Foundation Research Center at Le Bonheur Children's Medical Center, 50 North Dunlap, Memphis, TN 38103, USA.
Ault
Bettina H
BH
Jones
Deborah P
DP
Chesney
Russell W
RW
Wyatt
Robert J
RJ
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D005921:Glomerulonephritis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D011379:Prognosis; D013290:Streptococcal Infections / Q000276:immunology*