Lipidized glioblastoma: a rare differentiation pattern.
We report a rare case of lipidized glioblastoma arising in the tempo-parietal lobe of a 65 year-old woman. The tumor was composed of diffuse sheets of lipidized cells with abundant xanthomatous cytoplasm comprising 60% of the tumor mass. These cells revealed immunopositivity with glial fibrillary acidic protein (GFAP) and the accumulation of lipid was confirmed ultrastructurally. This report highlights the extremely rare lipidized differentiation pattern occurring in glioblastoma and adds observational data to the existing literature on lipid accumulation occurring in glioblastomas.
Gupta
Kirti
K
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. kirtigupta10@yahoo.co.in
Kalra
Ivreet
I
Salunke
Pravin
P
Vasishta
Rakesh K
RK
D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D002454:Cell Differentiation; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008055:Lipids
D008055:Lipids