title: [Research on mitochondrial DNA T1095C gene variation in military noise-induced hearing loss].
abstract: OBJECTIVE
  To study the clinical and sequence character of the entire mitochondrial genome in five subjects with mitochondrial 12SrRNA T1095C mutation, and to analyze its relationship with the military noise-induced hearing loss (NIHL).
  
  
  METHODS
  Three hundreds and four soldiers exposed to military noise were selected in Yunan and Beijing, including susceptible (experimental) and tolerance (control) groups. Mitochondrial 12SrRNA T1095C mutation were found in 5 subjects. Then the complete nucleotide sequence of five subjects were sequenced and its clinical character were analyzed.
  
  
  RESULTS
  m12SrRNA T1095C mutation were identified in 5 subjects of experimental group,and none were found in control group. There was significant difference between them (P < 0.05). All five soldiers had the history of military noise exposure and showed sensorineural deafness of different degrees. Sequence analysis of the complete mitochondrial genomes showed the distinct sets of mtDNA polymorphism besides T1095C mutation in five subjects.
  
  
  CONCLUSIONS
  The T1095C mutation in hearing loss subjects with various genetic background and history of military noise exposure, is involved in the pathogenesis of hearing impairment. It indicates that the T1095C mutation do relate well with military noise induced-hearing loss.
authors.affiliation: Department of Otorhinolaryngology, Kunming General Hospital, Kunming, 650032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qu
authors.forename: Xijun
authors.initials: X
authors.lastname: Xue
authors.forename: Pu
authors.initials: P
authors.lastname: Dai
authors.forename: Dongyi
authors.initials: D
authors.lastname: Han
authors.forename: Xianbao
authors.initials: X
authors.lastname: Cao
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yang
authors.forename: Fuyin
authors.initials: F
authors.lastname: Shao
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Ruili
authors.initials: R
authors.lastname: Yu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhong
mesh_terms: D000328:Adult; D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D008297:Male; D008889:Military Personnel; D009154:Mutation; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial