Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight.
We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM(2.5)) on offspring birth weight. Among newborns from LISA cohort, we tested if polymorphisms of GSTT1, GSTP1, GSTM1, and CYP2D6 genes modified the effect measure of PM(2.5) on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking). PM (2.5) exposure above the median value (reference, below) was associated with birth weight changes by 76 g in the homozygous wild type genotype (n=161), -90 g in the heterozygous genotype (n=154) and -168 g in children with GSTP1 *1B/*1B mutant genotype (n=39, interaction test, p=0.05). No effect measure modification with PM(2.5) was detected for GSTT1, GSTM1 or CYP2D6 polymorphisms (p≥ 0.12). No effect measure modification with GSTP1 polymorphism was detected for active (p=0.71) nor for passive smoking effects on birth weight (p=0.13).
Slama
Rémy
R
INSERM and University J. Fourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, U823, Institut Albert Bonniot, BP 170 La Tronche, Grenoble, France. Remy.slama@ujf-grenoble.fr
Gräbsch
Carolin
C
Lepeule
Johanna
J
Siroux
Valérie
V
Cyrys
Josef
J
Sausenthaler
Stefanie
S
Herbarth
Olf
O
Bauer
Mario
M
Borte
Michael
M
Wichmann
H Erich
HE
Heinrich
Joachim
J
D000328:Adult; D001724:Birth Weight / Q000235:genetics; D002648:Child; D015331:Cohort Studies; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D056726:Genetic Association Studies; D005858:Germany; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics*; D018811:Maternal Exposure / Q000009:adverse effects*; D009154:Mutation; D052638:Particulate Matter / Q000633:toxicity*; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects; D001335:Vehicle Emissions; D055815:Young Adult
D019389:Cytochrome P-450 CYP2D6; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D052638:Particulate Matter; D001335:Vehicle Emissions; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human