title: Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy.
abstract: OBJECTIVE
  To evaluate a possible correlation between transvaginal ultrasound findings in miscarriages and cytogenetic analyses from chorionic villi obtained by dilatation and curettage.
  
  
  METHODS
  Prospective, population-based study.
  
  
  METHODS
  University-based hospital.
  
  
  METHODS
  Five hundred seventy-six women with spontaneous miscarriage diagnosed between 6 and 12 completed pregnancy weeks.
  
  
  METHODS
  Transvaginal ultrasonography and dilatation and curettage.
  
  
  METHODS
  Cytogenetic analyses and ultrasound measurement of embryonic pole.
  
  
  RESULTS
  The mean gestational age was 9.5 weeks. Chromosomal analyses were successful in 259 cases, 159 with cytogenetic abnormalities and 100 euploidy. Empty gestational sacs were equally often found in euploidy and aneuploidy, whereas small embryonic or fetal poles were significantly more often associated with aneuploidy.
  
  
  CONCLUSIONS
  A smaller than expected fetal size when a miscarriage is diagnosed during the first trimester is significantly associated with a chromosomal aberration.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, and Uppsala Hospital, Uppsala, Sweden.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ljunger
authors.forename: Anneli
authors.initials: A
authors.lastname: Stavreus-Evers
authors.forename: Sven
authors.initials: S
authors.lastname: Cnattingius
authors.forename: Anders
authors.initials: A
authors.lastname: Ekbom
authors.forename: Catarina
authors.initials: C
authors.lastname: Lundin
authors.forename: Göran
authors.initials: G
authors.lastname: Annéren
authors.forename: Inger
authors.initials: I
authors.lastname: Sundström-Poromaa
mesh_terms: D000022:Abortion, Spontaneous / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D000328:Adult; D000782:Aneuploidy; D002824:Chorionic Villi / Q000473:pathology*; D002869:Chromosome Aberrations; D004107:Dilatation and Curettage; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal