title: Modelling neutral lipid production by the microalga Isochrysis aff. galbana under nitrogen limitation.
abstract: This article proposes a dynamical model of microalgal lipid production under nitrogen limitation. In this model, intracellular carbon is divided between a functional pool and two storage pools (sugars and neutral lipids). The various intracellular carbon flows between these pools lead to a complex dynamic with a strong discrepancy between synthesis and mobilization of neutral lipids. The model has been validated with experiments of Isochrysis aff. galbana (clone T-iso) culture under various nitrogen limitation conditions and under nitrogen starvation. The hysteresis behavior of the neutral lipid quota observed experimentally is accurately predicted.
authors.affiliation: COMORE-INRIA, BP93, 06902 Sophia-Antipolis Cedex, France. francis.mairet@inria.fr
authors.forename: Francis
authors.initials: F
authors.lastname: Mairet
authors.forename: Olivier
authors.initials: O
authors.lastname: Bernard
authors.forename: Pierre
authors.initials: P
authors.lastname: Masci
authors.forename: Thomas
authors.initials: T
authors.lastname: Lacour
authors.forename: Antoine
authors.initials: A
authors.lastname: Sciandra
mesh_terms: D002241:Carbohydrates / Q000096:biosynthesis; D002244:Carbon / Q000378:metabolism; D018929:Cell Culture Techniques / Q000379:methods; D002999:Clone Cells; D056890:Eukaryota / Q000254:growth & development* / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism; D044367:Phase Transition; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013217:Starvation
chemical_list: D002241:Carbohydrates; D008055:Lipids; D002244:Carbon; D009584:Nitrogen