Preparation and physicochemical properties of the complex of naringenin with hydroxypropyl-beta-cyclodextrin.
In this study a complex of naringenin with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The result showed that naringenin had been molecularly dispersed in the HP-beta-CD matrix, not forming a new compound and HPLC analysis showed that the solubility of naringenin in water was enhanced from 4.38 microg/mL to 1,272.31 microg/mL.
Wen
Jiping
J
College of Grain and Food, Henan University of Technology, Zhengzhou 450052, China. wjp1380@163.com
Liu
Benguo
B
Yuan
Erdong
E
Ma
Yuxiang
Y
Zhu
Yongyi
Y
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D044950:Flavanones / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D044950:Flavanones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C005273:naringenin