Striatal functional connectivity networks are modulated by fMRI resting state conditions.
Resting state fluctuations in blood oxygenation level dependent functional connectivity magnetic resonance imaging (BOLD fcMRI) time-series have been increasingly employed to study functional connectivity networks in healthy and diseased brain. FcMRI studies have been conducted under a number of different conditions, including resting eyes open, visual fixation and finger tapping. BOLD fcMRI networks are believed to reflect both anatomically constrained spontaneous fluctuations and state-dependent activity. In this study, state-dependence of functional connectivity to dorsal and ventral striatum was assessed with fcMRI during an eyes open resting state condition (REST) and during continuous 3 Hz transcutaneous electrical nerve stimulation (TENS), with the a priori hypotheses: (1) dorsal striatum connectivity with sensorimotor/attention networks will be stronger during TENS compared to REST, (2) ventral striatum connectivity with limbic system emotion-processing network will be weaker during TENS compared to REST and (3) ventral striatum connectivity with sensorimotor/attention networks will be stronger during TENS compared to REST. These hypotheses were confirmed by the results obtained, indicating that resting state BOLD fMRI networks reflect, in substantial measure, state-dependent activity.
Gopinath
Kaundinya
K
Department of Radiology, Division of Neuroradiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8896, USA. kaundinya.gopinath@utsouthwestern.edu
Ringe
Wendy
W
Goyal
Aman
A
Carter
Kirstine
K
Dinse
Hubert R
HR
Haley
Robert
R
Briggs
Richard
R
D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000502:physiology; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000502:physiology; D004522:Educational Status; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D005403:Fixation, Ocular; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008475:Median Nerve / Q000502:physiology; D009043:Motor Activity; D009415:Nerve Net / Q000502:physiology; D010100:Oxygen / Q000097:blood*; D012146:Rest / Q000502:physiology*; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology
D010100:Oxygen