title: Interleukin-6 levels in tension headache patients.
abstract: OBJECTIVE
  Cytokines are pain mediators in neurovascular inflammation. This study examined interleukin 6 (IL-6) levels in the serum of tension-type headache (TTH) patients, to determine if inflammation plays a role in the pathogenesis of this condition.
  
  
  METHODS
  Serum IL-6 levels were studied in 42 patients and 37 healthy controls from the same region. Of the patients, 20 (47.6%) experiencing TTH less than 15 days per month were placed in episodic tension-type headache (ETTH) group, and 22 (52.3%) with TTH more than 15 days per month were placed in chronic tension-type headache (CTTH) group.
  
  
  RESULTS
  The IL-6 level was significantly higher in the patients than in the controls. The IL-6 level of CTTH patients was higher than the controls (P<0.01). The IL-6 level was similar between ETTH and CTTH patients. Correlation analysis revealed a positive relationship only between age and IL-6 level in the patients.
  
  
  CONCLUSIONS
  CTTH and ETTH patients had an elevated serum IL-6 level compared with controls. Therefore, we believe that IL-6 may be involved in pain induction or inflammatory mechanisms in TTH. Furthermore studies of the possible connection between chronicity of headaches and cytokine levels are needed.
authors.affiliation: Department of Neurology, Düzce University Medical Faculty, Turkey. abdulkadirkocer@yahoo.com
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Koçer
authors.forename: Emel
authors.initials: E
authors.lastname: Koçer
authors.forename: Ramazan
authors.initials: R
authors.lastname: Memişoğullari
authors.forename: Füsun M
authors.initials: FM
authors.lastname: Domaç
authors.forename: Hatice
authors.initials: H
authors.lastname: Yüksel
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018781:Tension-Type Headache / Q000097:blood* / Q000276:immunology; D055815:Young Adult
chemical_list: D015850:Interleukin-6