Comment on "A stationary-wave model of enzyme catalysis" by Carlo Canepa.
Energy barriers for enzyme-catalyzed reactions calculated with quantum mechanics/molecular mechanics (QM/MM) and empirical valence bond (EVB) methods can be in excellent agreement with activation energies derived from experiments, supporting the applicability of transition state theory for enzymic reactions.
Lonsdale
Richard
R
Harvey
Jeremy N
JN
Manby
Frederick R
FR
Mulholland
Adrian J
AJ
D001665:Binding Sites; D055162:Biocatalysis; D003198:Computer Simulation; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D017711:Nonlinear Dynamics; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D004798:Enzymes; D014867:Water