title: Comparison of peptic ulcer disease risk between peritoneal and hemodialysis patients.
abstract: BACKGROUND
  Compared to the general population, patients with end-stage renal disease (ESRD) have increased peptic ulcer and upper GI bleeding complication rates. However, the risk factors for peptic ulcer among ESRD patients are unknown.
  
  
  METHODS
  In this retrospective study, we enrolled 827 incident dialysis patients and diagnosed peptic ulcer on the basis of endoscopic findings; information on the morbidities and medical prescription were obtained directly from medical records. A Cox regression hazard model was used to identify risk factors for peptic ulcer.
  
  
  RESULTS
  During the 10-year study period, 481 patients underwent an endoscopic exam. Peptic ulcers were detected in 153 patients. Age (p = 0.025), peritoneal dialysis (p = 0.022), diabetes mellitus (p = 0.020), congestive heart failure (p = 0.015), low serum albumin (p = 0.008) and high gamma-glutamyl transpeptidase (γ-GT) levels (p = 0.002) are risk factors for peptic ulcers among ESRD patients. Ulcer severity (p = 0.004) and aspirin prescription (p = 0.043), but not Helicobacter pylori infection, influenced the ulcer recurrence rate.
  
  
  CONCLUSIONS
  The risk factors for peptic ulcer have some differences between ESRD patients and general population. In patients with high risk of upper GI bleeding, peritoneal dialysis and aspirin should be prescribed with caution.
authors.forename: Yung-Tai
authors.initials: YT
authors.lastname: Chen
authors.forename: Wu-Chung
authors.initials: WC
authors.lastname: Yang
authors.forename: Chih-Ching
authors.initials: CC
authors.lastname: Lin
authors.forename: Yee-Yung
authors.initials: YY
authors.lastname: Ng
authors.forename: Jinn-Yang
authors.initials: JY
authors.lastname: Chen
authors.forename: Szu-Yuan
authors.initials: SY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology / Q000209:etiology*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors