title: Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917.
abstract: The beneficial effect of probiotic Escherichia coli strain Nissle 1917 (EcN) suggests the gut epithelium plays a basic role in immune interactions with bacteria. Contrary to other commensal strains of Escherichia coli, EcN profoundly modulates the gut barrier to elevate its resistance to microbial pathogens. The present review documents the properties of EcN that have led to the protection of gnotobiotic pigs against lethal enteric infections. This effect could be important in light of the growing number of acquired deficiencies that paralyze gut immunity in humans.
authors.affiliation: Division of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic.
authors.forename: Ilja
authors.initials: I
authors.lastname: Trebichavsky
authors.forename: Igor
authors.initials: I
authors.lastname: Splichal
authors.forename: Vojtech
authors.initials: V
authors.lastname: Rada
authors.forename: Alla
authors.initials: A
authors.lastname: Splichalova
mesh_terms: D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology; D004926:Escherichia coli; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D056747:Immunomodulation / Q000187:drug effects* / Q000276:immunology; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D019936:Probiotics / Q000494:pharmacology*