title: Flavonoids, cinnamic acid and phenyl propanoid from aerial parts of Scrophularia striata.
abstract: No phytochemical investigation regarding Scrophularia striata Boiss. (Scrophulariaceae) has been performed, although several reports about other Scrophularia species have been published. The inhibitory effects of aerial parts of S. striata on matrix metalloproteinase expression elaborate a new approach to treat variety of malignant and inflammatory disorders. Five known compounds, including cinnamic acid, three flavonoids (quercetine, isorhamnetin-3-O-rutinoside and nepitrin) and one phenyl propanoid glycoside (acteoside 1) were isolated from S. striata Boiss. by chromatographic techniques and the structures of compounds were characterized by spectroscopic methods. This is the first report regarding the isolation of these compounds from S. striata.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Monsef-Esfahani
authors.forename: Reza
authors.initials: R
authors.lastname: Hajiaghaee
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Shahverdi
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Khorramizadeh
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
mesh_terms: D005591:Chemical Fractionation; D002934:Cinnamates / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D005960:Glucosides / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D007492:Iran; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008519:Medicine, Traditional; D015394:Molecular Structure; D010636:Phenols / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry*; D032266:Scrophularia / Q000737:chemistry*; D059808:Polyphenols
chemical_list: D002934:Cinnamates; D005419:Flavonoids; D005960:Glucosides; D010636:Phenols; C029010:cinnamic acid; C058956:acteoside; D059808:Polyphenols