title: Monozygotic twins with idiopathic internal root resorption: A case report.
abstract: This study presents the first case of internal root resorption in monozygotic twins. Genetic factors have been implicated in the development of root resorption lesions. The link between interleukin (IL)-1 gene polymorphism and root resorption had been reported. However, these studies have involved external root resorption. Twin healthy 17 year old Caucasian sisters were diagnosed with internal root resorption in their upper left central incisor. Neither had a history of orofacial trauma and neither had received orthodontic treatment. The presence of IL-1beta+C3953 allele is the sign of predisposed susceptibility to an exaggerated inflammatory response, including a limited feedback mechanism as a consequence of IL-1RN mutation. Most investigators agree that the listed polymorphism presents a significantly higher risk for development of pathological resorption. These were thought to be cases of true idiopathic resorption as none of the other factors related to root resorption was found.
authors.affiliation: 1st Department of Stomatology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia. danielurban@me.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Urban
authors.forename: Jozef
authors.initials: J
authors.lastname: Mincik
mesh_terms: D000293:Adolescent; D000483:Alleles; D004200:Diseases in Twins; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007180:Incisor / Q000473:pathology; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D012390:Root Canal Therapy; D012391:Root Resorption / Q000235:genetics*; D014430:Twins, Monozygotic
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta