Spontaneous reduction before 12 weeks' gestation and selective reduction similarly extend time to delivery in in vitro fertilization of trichorionic-triamniotic triplets.
OBJECTIVE
To determine the prevalence and the relative benefits conferred by selective and spontaneous reduction of one or more fetuses in trichorionic triamniotic triplet pregnancies on time to delivery.


METHODS
Retrospective cohort study.


METHODS
Academic medical center.


METHODS
IVF patients with trichorionic triamniotic triplets between January 1998 and December 2007.


METHODS
None.


METHODS
Gestational length at time of delivery.


RESULTS
Selective reduction to twins was used in 87 of the 153 (56.9%) triplet pregnancies that did not spontaneously reduce prior to <12 weeks, and was associated with longer gestation (13.9 days) with a fourfold greater likelihood of delivery at ≥ 34 weeks' gestation (odds ratio [OR], 4.3; 95% confidence interval [CI] = 2.2-8.6), compared with pregnancies not undergoing selective reduction. Compared with ongoing triplets, spontaneous reduction at <12 weeks' gestation (28 cases) was associated with longer gestation (13.7 days) and significantly greater likelihood delivering at or after 34 weeks' gestation (OR, 3.7; 95% CI, 1.4-9.9).


CONCLUSIONS
Selective reduction of one fetus was used in 56.9% of patients in this population. Early spontaneous reduction (<12 weeks) and selective reduction to twins each conferred similar benefits by extending time to delivery and increasing the likelihood of delivery at or after 34 weeks' gestation.
Skiadas
Christine C
CC
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Missmer
Stacey A
SA
Benson
Carol B
CB
Acker
David
D
Racowsky
Catherine
C
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000503:physiopathology; D000328:Adult; D000465:Algorithms; D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal / Q000534:rehabilitation / Q000706:statistics & numerical data; D011261:Pregnancy Trimester, First / Q000502:physiology; D011272:Pregnancy, Multiple / Q000502:physiology* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013997:Time Factors; D014310:Triplets / Q000502:physiology; D014429:Twins, Dizygotic / Q000502:physiology