New sesquiterpene coumarins from the roots of Ferula flabelliloba.
Three new sesquiterpene coumarins, namely, farnesiferone B (1), flabellilobin A (2) and flabellilobin B (3), together with nine known compounds, ligupersin A, 7-epi-gamma-eudesmol, persicasulfide A, conferdione, umbelliprenin, conferone, feselol, lehmferin and farnesiferol B were isolated from the roots of Ferula flabelliloba Rech. f. & Aell. (Apiaceae). The structures of these compounds were elucidated by various 1- and 2-D NMR techniques as well as HREIMS.
Iranshahi
Mehrdad
M
Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Iranshahim@mums.ac.ir
Kalategi
Farhad
F
Sahebkar
Amirhossein
A
Sardashti
Alireza
A
Schneider
Bernd
B
D003374:Coumarins / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D004220:Disulfides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D055808:Drug Discovery; D005309:Ferula / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D045787:Sesquiterpenes, Eudesmane / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D014468:Umbelliferones / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification
D003374:Coumarins; D004220:Disulfides; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D014468:Umbelliferones; C553645:farnesiferone B; C553646:flabellilobin A; C553647:flabellilobin B