Improvement of hyperglycemia and sexual dysfunction in diabetic female rats by an artificial endocrine pancreas developed from mouse beta cells.
We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse beta cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse beta cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380-450 mg/dl induced by streptozotocin to 140-230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.
Hashimoto
Haruo
H
Central Institute for Experimental Animals, Kawasaki-shi, Kanagawa, Japan.
Moritani
Naoki
N
Terada
Misao
M
Kromkhun
Pudcharaporn
P
Fungfuaug
Wirasak
W
Nakada
Tomoaki
T
Yokosuka
Makoto
M
Saito
Toru R
TR
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006943:Hyperglycemia / Q000601:surgery*; D050417:Insulin-Secreting Cells; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D051379:Mice; D010052:Ovariectomy; D019397:Pancreas, Artificial; D011187:Posture; D051381:Rats; D012726:Sexual Behavior, Animal / Q000502:physiology; D012735:Sexual Dysfunction, Physiological / Q000503:physiopathology / Q000601:surgery*; D014183:Transplantation, Heterologous