title: Comment on "A stationary-wave model of enzyme catalysis" by Carlo Canepa.
abstract: Energy barriers for enzyme-catalyzed reactions calculated with quantum mechanics/molecular mechanics (QM/MM) and empirical valence bond (EVB) methods can be in excellent agreement with activation energies derived from experiments, supporting the applicability of transition state theory for enzymic reactions.
authors.forename: Richard
authors.initials: R
authors.lastname: Lonsdale
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Harvey
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Manby
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Mulholland
mesh_terms: D001665:Binding Sites; D055162:Biocatalysis; D003198:Computer Simulation; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D017711:Nonlinear Dynamics; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D004798:Enzymes; D014867:Water