[Immunity against Mycobacterium tuberculosis (introduction)].
A third of world's population infected with Mycobacterium tuberculosis, and 2 million people die from tuberculosis every year. It is well established that protective to M. tuberculosis depends on both CD4+ and CD8+ T cells. In particular, acquired immunity (cytotoxic T cell, Th1 helper T cell and M phi) play an important role for TB infection. Recently, natural immunity also play a very attractive role for the development of TB immunity. We found that memory CTL is most important for the protection against TB using several kinds of mice. It was demonstrated that DBA/1 mice are more sensitive to TB infection than BALB/c mice (Th2 prone mice). Induction of memory CTL in DBA/1 mice was lower than BALB/c. In contrast, IFN-gamma production of DBA/1 mice was higher than BALB/c. Therefore, famous researchers in the fields of TB immunity reviewed the recent advances of TB immunity, such as (1) T cell immunity and recognition against TB antigen, (2) TLR9 and CpG motif, (3) lipocalin2 and SLPI in natural TB immunity, (4) acquired immunity (CTL) and granulysin. The development novel vaccine (HSP65+IL-12 DNA vaccine), (5) The mechanism of protection against TB, in this mini-review series.
Okada
Masaji
M
Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, 1180 Nagasone-cho, Kita-ku, Sakai-shi, Osaka 591-8555, Japan. okm@kch.hosp.go.jp
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology