Design and synthesis of HCV agents with sequential triple inhibitory potentials.
The union of HCV-796, a potent selective HCV NS5B polymerase inhibitor, and Ribavirin, a molecule with activities against a wide spectrum of viruses, resulted in a class of new anti-HCV agents with a sequential triple inhibitory mechanism.
Zhu
Tianmin
T
Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Fawzi
Mahdi B
MB
Flint
Michael
M
Kong
Fangming
F
Szeliga
Jan
J
Tsao
Russ
R
Howe
Anita Y M
AY
Pan
Weitao
W
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents