Synthesis and effect on human HepG2 cells of 1,2-bis-(2-methylallyl)disulfane.
1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.
Ji
Chunxiao
C
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China. cx312@163.com
Ren
Fenglian
F
Dai
Jun
J
Xu
Ming
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005434:Flow Cytometry; D008401:Gas Chromatography-Mass Spectrometry; D056945:Hep G2 Cells; D006801:Humans; D011506:Proteins / Q000032:analysis; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011506:Proteins; D013457:Sulfur Compounds