title: [Pathological characteristics and clinical significance of macrochilia secondary to venular malformation].
abstract: OBJECTIVE
  To analyze the histologic characteristics of macrochilia secondary to port-wine stain and to elucidate the possible mechanism.
  
  
  METHODS
  Twenty-one cases of macrochilia secondary to venular malformation were included and the histology of the lesions was observed by light microscope.
  
  
  RESULTS
  Histological examination revealed vascular abnormalities and a number of widely distributed hamartomatous changes in macrochilia secondary to venular malformation. The average vessel diameter is (39.8 +/- 15.7) microm. The degree of hamartomatous change: mild (1 case), moderate (7 cases) and severe (13 cases).
  
  
  CONCLUSIONS
  The complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of venular malformation.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiao-xi
authors.initials: XX
authors.lastname: Lin
authors.forename: Gang
authors.initials: G
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Hu
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006222:Hamartoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008046:Lip / Q000002:abnormalities* / Q000473:pathology; D008047:Lip Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D019339:Port-Wine Stain / Q000150:complications / Q000473:pathology*; D055815:Young Adult