Antimutagenic and antioxidant potentials of Teucrium ramosissimum essential oil.
The mutagenic and antimutagenic effects of the essential oil extracted from the aerial parts of Teucrium ramosissimum were evaluated by the bacterial reverse mutation assay in Salmonella typhimurium TA98, TA100, and TA1535, with and without exogenous metabolic activation (S9 fraction). The T. ramosissimum essential oil showed no mutagenic effect. In contrast, our results established that it possessed antimutagenic effects against sodium azide (SA), aflatoxin B1 (AFB1), benzo[a]pyrene (B[a]P), and 4-nitro-o-phenylenediamine (NOPD). The antioxidant capacity of the tested essential oil was evaluated using enzymatic, i.e., the xanthine/xanthine oxidase (X/XOD) assay, and nonenzymatic systems, i.e., the nitro-blue tetrazolium (NBT)/riboflavin and the DPPH assays. A moderate free radical-scavenging activity was observed towards DPPH(.) and O2(.-). In contrast, T. ramosissimum essential oil showed no effect for all the tested concentrations in the X/XOD assay.
Sghaier
Mohamed Ben
MB
Department of Pharmacognosy, Faculty of Pharmacy, Rue Avicenne, Monastir 5000, Tunisia.
Boubaker
Jihed
J
Neffati
Aicha
A
Limem
Ilef
I
Skandrani
Ines
I
Bhouri
Wissem
W
Bouhlel
Ines
I
Kilani
Soumaya
S
Chekir-Ghedira
Leila
L
Ghedira
Kamel
K
D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D031367:Teucrium / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000378:metabolism
D016587:Antimutagenic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D009822:Oils, Volatile; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase