A case of autoimmune retinopathy associated with thyroid carcinoma.
OBJECTIVE
To report a case of autoimmune retinopathy (AIR) associated with a thyroid carcinoma.


METHODS
Case report.


METHODS
A 51-year-old Caucasian woman presented with a rapid decline in vision. Initial visual field and immunohistochemical testing revealed autoimmune retinopathy without an apparent underlying malignancy. Conventional local and systemic immunosuppressive therapies failed to halt the progression.


RESULTS
Rituximab treatments were initiated and a slowing of visual loss was seen. Continued surveillance for malignancy revealed a thyroid adenoma, and later a thyroidectomy revealed a thyroid carcinoma.


CONCLUSIONS
This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR.
Mahdi
Nicole
N
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Faia
Lisa J
LJ
Goodwin
James
J
Nussenblatt
Robert B
RB
Sen
H Nida
HN
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002277:Carcinoma / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000069283:Rituximab; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D000069283:Rituximab