title: Effect of testosterone therapy for delayed growth and puberty in boys with inflammatory bowel disease.
abstract: BACKGROUND
  pubertal delay and growth retardation are common in children with inflammatory bowel disease (IBD).
  
  
  OBJECTIVE
  To assess pubertal status and growth in a group of boys with IBD undergoing testosterone therapy for pubertal induction.
  
  
  METHODS
  retrospective study of height, weight and pubertal status in 8 boys with IBD before and after testosterone therapy. Height velocity (HV) over the 6 months before each assessment was converted to standard deviation score. Markers of disease activity and concomitant medication were recorded. Response was based on an advance in pubertal status and a greater than 50% increase in HV.
  
  
  RESULTS
  eight boys with IBD, median age 14.8 years, had pubertal induction using either monthly injections of 50 mg Sustanon or daily 2.5/5 mg Andropatch. Seven boys showed an advance of pubertal status. Six boys had a greater than 50% increase in HV; median HV at T0 was 1.6 cm/year (0, 5) compared with 6.9 cm/year (1, 11.7) at T6 (p = 0.005). C-reactive protein during testosterone therapy had a significant association with HV at T6 (r = -0.786; p = 0.021).
  
  
  CONCLUSIONS
  in most cases, testosterone therapy in boys with IBD and delayed growth and puberty is associated with an advance in pubertal status and an improvement in growth.
authors.affiliation: Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Sick Children, Glasgow, UK.
authors.forename: A
authors.initials: A
authors.lastname: Mason
authors.forename: S C
authors.initials: SC
authors.lastname: Wong
authors.forename: P
authors.initials: P
authors.lastname: McGrogan
authors.forename: S F
authors.initials: SF
authors.lastname: Ahmed
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000627:therapeutic use*; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002097:C-Reactive Protein / Q000032:analysis; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D011628:Puberty, Delayed / Q000188:drug therapy* / Q000209:etiology; D012189:Retrospective Studies; D013739:Testosterone / Q000627:therapeutic use*
chemical_list: D000728:Androgens; D013739:Testosterone; D002097:C-Reactive Protein