Thrombus aspiration in ST elevation myocardial infarction: comparative efficacy in patients treated early and late after onset of symptoms.
BACKGROUND
Restoration of myocardial perfusion is the goal of percutaneous coronary intervention (PCI) in patients with ST elevation myocardial infarction. A major predictor of no-reflow is the increasing time to treatment (TTT). Thrombus aspiration (TA) is reported to improve myocardial reperfusion as compared with standard PCI (SP).


OBJECTIVE
To investigate the influence of TTT on TA efficacy.


METHODS
Pooled analysis of individual patients' data of three prospective randomised trials comparing TA and SP.


METHODS
A total of 299 patients (150 in TA group and 149 in SP group) entered the study. The study population was divided into three subgroups according to the TTT: < or = 3 h (short TTT subgroup), >3 h to < or = 6 h (intermediate TTT subgroup), >6 h to < or = 12 h (long TTT subgroup).


METHODS
The goal of the study was the comparison of optimal myocardial reperfusion, defined as the combination of myocardial blush grade 2 or 3 at post-PCI angiography and ST resolution more than 70% at post-PCI ECG, between SP and TA according to TTT.


RESULTS
In the SP group, increasing TTT was associated with a decreased rate of optimal reperfusion (27.4% vs 17.9% vs 10%, p for trend=0.06), whereas in the TA group the same trend was not seen (40.9% vs 33.8% vs 50%, p for trend=0.93). In a multivariate logistic regression model, a significant interaction (p=0.04) between time to treatment and thrombus aspiration was observed.


CONCLUSIONS
TA limits the adverse effects of TTT prolongation on myocardial reperfusion.
De Vita
Maria
M
Cardiology Department, Morgagni-Pierantoni Hospital, Forlì, Italy. mariarosariadevita77@libero.it
Burzotta
Francesco
F
Porto
Italo
I
Dudek
Dariusz
D
Lefèvre
Thierry
T
Trani
Carlo
C
Mielecki
Waldemar
W
Niccoli
Giampaolo
G
Biondi-Zoccai
Giuseppe G L
GG
Crea
Filippo
F
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D003328:Coronary Thrombosis / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D013396:Suction; D013997:Time Factors