The reaction of cyanoacetylhydrazine with omega-bromo(4-methyl)acetophenone: synthesis of heterocyclic derivatives with antitumor activity.
New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.
Mohareb
Rafat M
RM
Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt. raafat_mohareb@yahoo.com
Mohamed
Abeer A
AA
D000098:Acetophenones / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D011725:Pyridines; D013329:Structure-Activity Relationship; D014227:Triazines; D014407:Tumor Cells, Cultured
D000098:Acetophenones; D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D006834:Hydrazines; D011725:Pyridines; D014227:Triazines; C023666:pyridine; C038699:acetophenone; C014949:acetylhydrazine