title: Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.
abstract: Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines.
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Leslie N
authors.initials: LN
authors.lastname: Aldrich
authors.forename: Sydney L
authors.initials: SL
authors.lastname: Stoops
authors.forename: Brenda C
authors.initials: BC
authors.lastname: Crews
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Marnett
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
mesh_terms: D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D011758:Pyrroles; C551403:tambjamine K