Electrophysiological manifestations in adults with HIV/AIDS submitted and not submitted to antiretroviral therapy.
BACKGROUND
auditory evoked potentials (AEP) assess the neuroelectric activity on the auditory pathway -from the auditory nerve to the cerebral cortex - in response to an acoustic stimulus or event. Studies have demonstrated electrophysiological abnormalities in individuals with HIV/AIDS.


OBJECTIVE
to characterize the hearing electrophysiological manifestations in adults with HIV/AIDS by comparing the results obtained in the group exposed to antiretroviral therapy with those obtained in the group not exposed to such treatment.


METHODS
electrophysiological evaluation of hearing (Auditory Brainstem Response - ABR, Auditory Middle Latency Response - AMLR and P300) was conducted in 56 individuals with HIV/AIDS: 24 participants composed group I (not exposed to antiretroviral treatment) and 32 participants composed group II (exposed to treatment).


RESULTS
alterations in every AEP were observed in individuals with HIV/ AIDS, especially in the ABR. Indeed, the group exposed to antiretroviral treatment presented more alterations.


CONCLUSIONS
individuals with HIV/AIDS may present alterations on the central and peripheral auditory nervous system. The group exposed to antiretroviral therapy presents more alterations on the brainstem auditory pathway.
Matas
Carla Gentile
CG
Curso de Fonoaudiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. cgmatas@usp.br
Silva
Sara Manami
SM
Marcon
Bruna de Almeida
Bde A
Gonçalves
Isabela Crivellaro
IC
D000161:Acoustic Stimulation; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001301:Audiometry, Pure-Tone; D001304:Auditory Diseases, Central / Q000175:diagnosis / Q000209:etiology; D016022:Case-Control Studies; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D034381:Hearing Loss / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D055815:Young Adult