title: Midterm results of radiofrequency ablation versus nephrectomy for T1a renal cell carcinoma.
abstract: OBJECTIVE
  The aim of this study was to retrospectively evaluate midterm results of renal radiofrequency (RF) ablation compared to the results after nephrectomy in patients with T1a renal cell carcinoma (RCC).
  
  
  METHODS
  A total of 115 patients with a single RCC measuring </=4 cm (T1a) were included; 51 patients underwent RF ablation, 54 patients radical nephrectomy, and 10 patients partial nephrectomy. The survival and the percent decreases in glomerular filtration rate (GFR) were compared among the three treatments.
  
  
  RESULTS
  Although overall survival after RF ablation (75.0% at 5 years) was lower than those after radical and partial nephrectomy, the RCC-related survival (100% at 5 years) was comparable to those following radical nephrectomy (100% at 5 years) and partial nephrectomy (100% at 3 years). The disease-free survival (DFS) after RF ablation (98.0% at 5 years) was also comparable to those after radical nephrectomy (95.0% at 5 years) (P = 0.72) and partial nephrectomy (75.0% at 3 years) (P = 0.13). The percent decrease in the GFR at last follow-up in the RF ablation group (median 7.9%) was significantly lower than that in the radical nephrectomy group (median 29.0%) (P < 0.001) and comparable to that in the partial nephrectomy group (median 11.5%) (P = 0.73).
  
  
  CONCLUSIONS
  RF ablation provides RCC-related and DFS comparable to that found after nephrectomy with little loss of renal function.
authors.affiliation: Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, 514-8507, Japan. takaki-h@clin.medic.mie-u.ac.jp
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Takaki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yamakado
authors.forename: Norihito
authors.initials: N
authors.lastname: Soga
authors.forename: Kiminobu
authors.initials: K
authors.lastname: Arima
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Nakatsuka
authors.forename: Masataka
authors.initials: M
authors.lastname: Kashima
authors.forename: Junji
authors.initials: J
authors.lastname: Uraki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Yamada
authors.forename: Kan
authors.initials: K
authors.lastname: Takeda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sugimura
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome