title: No taste for methyl: methylation sensitive proteolysis in drug screening.
abstract: Methyltransferases and demethylases are emerging targets for epigenetic therapy. Wigle et al. (2010) present a new assay for the enzyme inhibition of methyltransferases and demethylases based on selective enzymatic cleavage of unmethylated versus methylated peptides and their subsequent electrophoretic separation.
authors.affiliation: Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
authors.forename: Elisabeth-Maria
authors.initials: EM
authors.lastname: Bissinger
authors.forename: Manfred
authors.initials: M
authors.lastname: Jung