title: Structure of single-wall peptide nanotubes: in situ flow aligning X-ray diffraction.
abstract: The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A(6)K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into beta-sheet ribbons that wrap helically to form the nanotube wall.
authors.affiliation: Dept of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK.
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.forename: David R
authors.initials: DR
authors.lastname: Nutt
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
authors.forename: Seyda
authors.initials: S
authors.lastname: Bucak
authors.forename: Celen
authors.initials: C
authors.lastname: Cenker
authors.forename: Ulf
authors.initials: U
authors.lastname: Olsson
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D045333:Nanotubes, Peptide / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D045333:Nanotubes, Peptide; D009842:Oligopeptides; C508692:acetyl-alanyl-alanyl-alanyl-alanyl-alanyl-alanyl-lysine