title: Familial aggregation in children affected by functional gastrointestinal disorders.
abstract: OBJECTIVE
  Adults with irritable bowel syndrome may often have a first-degree relative with abdominal pain and bowel problems. The aims of this study were to evaluate the prevalence of functional gastrointestinal disorders (FGIDs) in parents and siblings of children affected by FGIDs, the psychological profile of both children and parents affected by FGIDs, and whether independent factors could influence the prevalence of FGIDs in parents of children with and without FGIDs.
  
  
  METHODS
  One hundred three patients affected by FGIDs according to Rome III criteria and/or their parents and siblings filled out validated questionnaires for gastrointestinal (GI) symptoms, depression, and anxiety. These patients were compared with 65 age- and sex-matched controls referred to the Primary Care Center of the Department of Paediatrics at the University of Naples "Federico II" for non-GI symptoms.
  
  
  RESULTS
  The parents of children with FGIDs showed a significantly (P < 0.0001) higher prevalence of FGIDs compared with the parents of children without FGIDs. No significant differences between the groups were observed for marital status, parental occupation, education level, standard of living, and presence of anxiety and/or depression. An association between the children's and their parents' type of GI disorders was found in 33.9% (35/103) of patients. In particular, an association between the children's and mother's type of GI disorders was found in 25.2% (26/103) of patients.
  
  
  CONCLUSIONS
  To our knowledge, our study is the first to demonstrate that a large number of mothers of children with FGIDs have the same FGIDs as their children.
authors.affiliation: Department of Pediatrics, University of Naples Federico II, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Buonavolontà
authors.forename: P
authors.initials: P
authors.lastname: Coccorullo
authors.forename: R
authors.initials: R
authors.lastname: Turco
authors.forename: G
authors.initials: G
authors.lastname: Boccia
authors.forename: L
authors.initials: L
authors.lastname: Greco
authors.forename: A
authors.initials: A
authors.lastname: Staiano
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents; D015995:Prevalence; D012931:Social Environment; D011795:Surveys and Questionnaires