Novel 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs).
A series of 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H(+)/K(+) ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at N1, C5, and C7 position of 1H-pyrrolo[2,3-c]pyridine scaffold, we have observed that compounds 14f and 14g are potent APAs with H(+)/K(+) ATPase IC(50)=28 and 29 nM, respectively.
Yoon
Young Ae
YA
Yuhan Research Institute, Giheung-gu, Gyeonggi-do, Republic of Korea.
Kim
Dong Hoon
DH
Lee
Byoung Moon
BM
Kim
Tae Kyun
TK
Cha
Myung Hun
MH
Sim
Jae Young
JY
Kim
Jae Gyu
JG
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology; D020128:Inhibitory Concentration 50; D054328:Proton Pump Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013552:Swine
D054328:Proton Pump Inhibitors; D011725:Pyridines