Flow chemistry kinetic studies reveal reaction conditions for ready access to unsymmetrical trehalose analogues.
Monofunctionalization of trehalose, a widely-found symmetric plant disaccharide, was studied in a microreactor to give valuable kinetic insights that have allowed improvements in desymmetrization yields and the development of a reaction sequence for large scale monofunctionalizations that allow access to probes of trehalose's biological function.
Patel
Mitul K
MK
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UKOX1 3TA.
Davis
Benjamin G
BG
D007700:Kinetics; D015394:Molecular Structure; D014199:Trehalose / Q000031:analogs & derivatives* / Q000737:chemistry
D014199:Trehalose