title: Novel therapeutic option for orbital atypical lymphoid hyperplasia.
abstract: Ocular lymphoid tumours represent a spectrum of lymphoproliferative disease and can be subdivided into benign or reactive lymphoid hyperplasia, indeterminate or atypical lymphoid proliferations and malignant lymphoma. Treatment options include a wait and watch approach, systemic steroids, local radiotherapy or systemic chemotherapy. We describe a case of bilateral atypical lymphoid hyperplasia treated successfully with combination immunotherapy and radiotherapy. A 60-year-old lady presented with proptosis and left supra-orbital mass and was diagnosed to have bilateral atypical lymphoid hyperplasia. She had extensive extraocular facial infiltrates but no other sites of involvement on staging investigations. She was treated with eight doses of rituximab 375 mg/m² at weekly intervals with a good partial response, followed by consolidative radiotherapy. Rituximab may be an effective treatment adjunct/alternative for patients with atypical lymphoid hyperplasia of the orbit, particularly where widespread lesions preclude the use of initial radiotherapy.
authors.affiliation: Department of Haematology, The Canberra Hospital, Canberra, ACT, Australia. dipti.talaulikar@act.gov.au
authors.forename: Dipti
authors.initials: D
authors.lastname: Talaulikar
authors.forename: David
authors.initials: D
authors.lastname: Tridgell
authors.forename: David
authors.initials: D
authors.lastname: Leong
authors.forename: Jane E
authors.initials: JE
authors.lastname: Dahlstrom
authors.forename: Maya
authors.initials: M
authors.lastname: Cherian
authors.forename: Ian
authors.initials: I
authors.lastname: Prosser
authors.forename: Ken
authors.initials: K
authors.lastname: Sunderland
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008232:Lymphoproliferative Disorders / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009916:Orbital Diseases / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab