In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes.
N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).
Governa
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M
Clinica di Medicina del Lavoro Università di Ancona, Ospedale di Torrette, 60020 Torrette di Ancona, Italy.
Valentino
M
M
Monaco
F
F
Visoná
I
I
Amati
M
M