Does sodium thiosulphate delay presbyacusis?
BACKGROUND
This study compares the effects of sodium thiosulphate (STS) and normal saline on the prevention of hearing loss.


METHODS
Animal research laboratory.


METHODS
Sixteen mice were randomized to receive intraperitoneal injections of either normal saline or STS. Auditory brainstem response testing was used to determine baseline and posttreatment hearing thresholds over the course of 1 year.


RESULTS
Compared with saline, treatment with STS resulted in a statistically significant improvement in click and pure-tone thresholds until the end of the year.


CONCLUSIONS
STS can significantly delay hearing loss associated with age in this murine model.
Quddusi
Taeed
T
Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, Manitoba. taeed@shaw.ca
Blakley
Brian W
BW
Meen
Eric
E
Berard
Sylvie
S
Dewji
Zameel
Z
D000818:Animals; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006309:Hearing / Q000502:physiology; D007274:Injections, Intraperitoneal; D051379:Mice; D008810:Mice, Inbred C57BL; D011304:Presbycusis / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
D001557:Benzenesulfonates; C046836:thimerfonate