Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
Boschi
Donatella
D
Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Torino, Italy.
Giorgis
Marta
M
Cena
Clara
C
Talniya
Naveen Chandra
NC
Di Stilo
Antonella
A
Morini
Giuseppina
G
Coruzzi
Gabriella
G
Guaita
Elena
E
Fruttero
Roberta
R
Gasco
Alberto
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D007975:Leukotriene B4 / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D016859:Lipoxygenase Inhibitors; D007975:Leukotriene B4; D009569:Nitric Oxide; D001094:Arachidonate 5-Lipoxygenase; C063449:zileuton; D006918:Hydroxyurea