title: A second signal for autophagic cell death?
abstract: Dictyostelium cells in monolayers in vitro lend themselves well to a study of autophagic cell death (ACD). There is no apoptosis machinery in the protist Dictyostelium, no caspase nor Bcl-2 family members (except a paracaspase whose inactivation does not alter cell death), thus there is no apoptosis that could interfere with, or substitute for, nonapoptotic cell death. Also, Dictyostelium, a eukaryote, has a haploid genome, which facilitates random insertional mutagenesis.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Faculté des Sciences de Luminy, Aix Marseille Université, Marseille, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Giusti
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Luciani
authors.forename: Pierre
authors.initials: P
authors.lastname: Golstein
mesh_terms: D000818:Animals; D001343:Autophagy; D004023:Dictyostelium / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D017125:Genes, Protozoan; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D015800:Protozoan Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015800:Protozoan Proteins