Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention.
OBJECTIVE
This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention (PCI).


METHODS
The present study examined serial changes (5 min, 30 min, 2 h, 6 h, and 24 h after PCI) in circulating P-selectin, plasminogen activator inhibitor-1 (PAI-1), magnesium (Mg), and creatine kinase-myocardial band fraction (CK-MB) levels, which may be associated with restenosis and myocardial injury in patients undergoing PCI. The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up.


RESULTS
PCI induced an early elevation of P-selectin, which correlated positively with the inflation pressure used in the PCI procedure. PCI also caused a significant and sustained decrease in serum Mg in PCI patients, without an effect on PAI-1. An increase in CK-MB was observed in PCI patients, although values were within normal reference range. In addition, elevated P-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure, respectively.


CONCLUSIONS
Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI.
Ying
Shu-qin
SQ
Department of Cardiology, the Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Xiang
Mei-xiang
MX
Fang
Lu
L
Wang
Jian-an
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D023903:Coronary Restenosis / Q000473:pathology*; D003402:Creatine Kinase / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D015427:Reperfusion Injury; D013997:Time Factors
D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D003402:Creatine Kinase; D008274:Magnesium