title: [A case of the complications following glycerin enema which suggested malignant hyperthermia].
abstract: We experienced a case of the complications following glycerin enema which suggested malignant hyperthermia. A 73-year-old man with knee osteoarthritis was scheduled for total knee arthroplasty under general and epidural anesthesia. The patient received glycerin enema before surgery. After epidural catheterization, anesthesia was induced with thiopental, fentanyl, vecuronium and sevoflurane. The trachea was intubated and the patient was ventilated with sevoflurane-air-oxygen. Then, cola-like urine was drained and he became febrile up to 37.9 degrees C. Although there were no other symptoms suggesting malignant hyperthermia, the surgery was cancelled. We suspected not only hemolysis by the color of the serum and the blood chemistry, but also rhabdomyolysis by increased levels of serum creatine phosphokinase and myoglobin as well as urine myoglobin. He recovered uneventfully. On the third day, perirectal abscess and anal fissure were diagnosed, which were considered to be the cause of the fever. It is well-known that glycerin enema could cause hemolysis, but rabdomyolysis as a complication of glycerin enema has rarely been reported. We speculate that injection of hypertonic glycerin into the perirectal tissue could have caused rhabdomyolysis as well as hemolysis, which led to cola-like urine. The complications following glycerin enema can be incorporated to a differential diagnosis of malignant hyperthermia.
authors.affiliation: Department of Anesthesiology, Osaka National Organization Hospital, Osaka 540-0006.
authors.forename: Emi
authors.initials: E
authors.lastname: Maeda
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Mori
authors.forename: Eizo
authors.initials: E
authors.lastname: Amano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Akamatsu
authors.forename: Toshiki
authors.initials: T
authors.lastname: Okada
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D003937:Diagnosis, Differential; D004733:Enema / Q000009:adverse effects*; D005990:Glycerol / Q000009:adverse effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D005990:Glycerol