Automated synthesis of a 96 product-sized library of triazole derivatives using a solid phase supported copper catalyst.
This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
Jlalia
Ibtissem
I
Laboratoire de Pharmacologie Chimique et Génétique (UMR 8151 CNRS, U 1022 INSERM, IFR 2769), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech; 11, rue Pierre et Marie Curie, 75005 Paris, France. ibtissemj@yahoo.fr
Beauvineau
Claire
C
Beauvière
Sophie
S
Onen
Esra
E
Aufort
Marie
M
Beauvineau
Aymeric
A
Khaba
Eihab
E
Herscovici
Jean
J
Meganem
Faouzi
F
Girard
Christian
C
D001331:Automation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D005374:Filtration; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis*
D054852:Small Molecule Libraries; D014230:Triazoles; D003300:Copper