title: Mitochondrial biogenesis related endurance genotype score and sports performance in athletes.
abstract: We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
authors.affiliation: Genetics and Molecular Biology Laboratory, Life Sciences Division, The Zinman College of Physical Education and Sport Sciences at Wingate Institute, Israel. eynon@wincol.ac.il
authors.forename: Nir
authors.initials: N
authors.lastname: Eynon
authors.forename: Jonatan R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: Yoav
authors.initials: Y
authors.lastname: Meckel
authors.forename: María
authors.initials: M
authors.lastname: Morán
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000328:Adult; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D047494:PPAR delta / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010807:Physical Endurance / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D013177:Sports; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D006360:Heat-Shock Proteins; D047494:PPAR delta; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors