Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats.
In this study, we investigated the effect of fucoidan polysaccharide sulfuric acid ester (FPS) from Laminaria japonica Aresch (Laminariaceae) on hyperlipidemic rats. FPS notably reduced the concentration of serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) of hyperlipidemic rats and increased the concentration of high-density lipoprotein cholesterol (HDL-C) and the activities of lipoprotein lipase (LPL), hepatic lipoprotein (HL), and lecithin cholesterol acyltransferase (LCAT).
Huang
Ling
L
Department of Oncology, Guangdong Provincial People's Hospital, Guangzhou, China.
Wen
Kewei
K
Gao
Xuan
X
Liu
Yonghong
Y
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D007795:Laminaria / Q000737:chemistry*; D008055:Lipids / Q000097:blood; D008297:Male; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004041:Dietary Fats; D000960:Hypolipidemic Agents; D008055:Lipids; D011134:Polysaccharides; C007789:fucoidan