L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms.
OBJECTIVE
L-Carnitine is a crucial component of activated fatty acid transport. The aim of this study was to evaluate the effect of L-carnitine on patients with a history of mild heart failure and diastolic dysfunction.


METHODS
Twenty-nine patients with a history of NYHA functional class II symptoms and ejection fraction >45% with documented grade 1 diastolic dysfunction on echocardiogram were randomized in blinded fashion to receive 1,500 mg of L-carnitine daily for 3 months in comparison to a no treatment group (31 patients). Baseline echocardiographic and follow-up measurements of diastolic parameters were assessed after 3 months.


RESULTS
Important parameters of diastolic function improved in the L-carnitine group only: left atrial size (3.6 +/- 0.4 cm before treatment vs. 3.4 +/- 0.5 cm after treatment, p = 0.01); isovolemic relaxation time (127 +/- 26 ms before vs. 113 +/- 24 ms after treatment, p = 0.007); septal mitral E' velocity (0.064 +/- 0.01 m/s before vs. 0.074 +/- 0.01 m/s after treatment, p = 0.01), and lateral mitral E velocity (0.082 +/- 0.01 m/s before vs. 0.091 +/- 0.02 m/s after treatment, p = 0.006). Dyspnea also significantly improved in L-carnitine-treated patients.


CONCLUSIONS
In patients with a history of diastolic heart failure, important indices of diastolic function and symptoms appear to improve with L-carnitine treatment.
Serati
Ali Reza
AR
Cardiovascular Research Center, Modarres Hospital, Tehran, Iran.
Motamedi
Mohammad Reza
MR
Emami
Sepideh
S
Varedi
Peyman
P
Movahed
Mohammad Reza
MR
D000328:Adult; D000368:Aged; D002331:Carnitine / Q000627:therapeutic use*; D004417:Dyspnea; D004452:Echocardiography; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use*
D005227:Fatty Acids; D014803:Vitamin B Complex; D002331:Carnitine