The EXTREME registry: titanium-nitride-oxide coated stents in small coronary arteries.
OBJECTIVE
We sought to explore the immediate results of Titan2 stent implantation in small coronary arteries, as well as the incidence of major adverse cardiac events (MACE) at six months follow-up.


BACKGROUND
The safety of Titan2 stent has been confirmed in several studies in real-life unselected populations.


METHODS
We enrolled 311 consecutive patients admitted for percutaneous intervention for at least one significant (50%) de novo lesion in a native small coronary artery (2.0-2.75 mm). All lesions were treated with Titan2 stent implantation. Patients were prospectively followed up for at least six months. The primary endpoint was MACE at six months follow-up [death, myocardial infarction (MI), or target vessel revascularization (TVR)]. Secondary endpoints included angiographic and clinical procedural success, in-hospital MACE, target lesion revascularization (TLR) during follow-up, and stent thrombosis.


RESULTS
The mean age was 67.3 +/- 10.9 years (65.9% males). A total of 356 Titan2 stents were implanted in 353 lesions. Angiographic and clinical procedural success was achieved in 344 (97.5%) patients. No case of in-hospital MACE or acute stent thrombosis was reported. Clinical follow-up was completed for an average of 8 +/- 2 months. Two patients (0.7%) died, and 6 (2.1%) developed MI. TLR was performed in 12 (4.2%) and TVR in 16 (5.5%) patients, all were clinically driven. Cumulative MACE occurred in 20 (6.9%) patients. One patient suffered subacute stent thrombosis, but no late stent thrombosis.


CONCLUSIONS
Titan2 stent implantation in small coronary arteries achieves excellent immediate outcome, with a low incidence of MACE at mid-term follow-up.
Valdesuso
Raúl
R
Cardiology Department, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Karjalainen
Pasi
P
García
Joan
J
Díaz
José
J
Portales
Javier Fernández
JF
Masotti
Mónica
M
Picó
Francisco
F
Serra
Antonio
A
Burgos
José Moreu
JM
Insa
Luis
L
Mauri
Fina
F
Collado
Javier Rodriguez
JR
Nammas
Wail
W
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D011446:Prospective Studies; D011474:Prosthesis Design; D012042:Registries; D015607:Stents; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors; D014025:Titanium; D016896:Treatment Outcome
D020099:Coated Materials, Biocompatible; C434243:titanium-nitride-oxide; D014025:Titanium