Total synthesis of batatoside L.
The total synthesis of batatoside L (1), a resin glycoside possessing cytotoxicity against laryngeal carcinoma cells, has been completed in a highly convergent manner. The most crucial step in this total synthesis was the efficient construction of the 18-membered macrolactone framework through the Corey-Nicolaou macrolactonization approach.
Xie
Lin
L
Key Laboratory of Drug Targeting and Delivery Systems, Ministry of Education, and Department of Chemistry of Medicinal Natural Products, School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China.
Zhu
San-Yong
SY
Shen
Xiao-Qiu
XQ
He
Li-Li
LL
Yang
Jin-Song
JS
D027722:Convolvulaceae / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D012116:Resins, Plant / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D046911:Macromolecular Substances; D009844:Oligosaccharides; D012116:Resins, Plant; C553644:batatoside L