title: Serum protein electrophoresis in 155 cats.
abstract: All serum protein electrophoresis (SPE) results obtained between 2002 and 2009 from clinical cases presented to the University of Bristol Feline Centre were examined retrospectively. One hundred and fifty-five results met the inclusion criteria. Signalment and final diagnoses were obtained from the case records. Clinical cases were classified as having normal or abnormal SPE results by comparison to reference intervals for SPE created using 77 clinically normal cats. Abnormal results were then further divided according to the specific SPE abnormality. Cases were also categorised, according to the final diagnosis, using the DAMNITV classification system. Of the 155 cases, 136 (87.7%) had abnormal SPE results, most commonly due to a polyclonal increase in gamma globulins. A monoclonal gammopathy occurred in four cats; one with feline infectious peritonitis (FIP), one with lymphoma and two cases of splenic plasmacytoma (one suspected, one confirmed). The most common DAMNITV classification associated with SPE abnormalities was infectious/inflammatory disease (80/136; 58.8%), including 39 cats diagnosed with FIP.
authors.affiliation: The Feline Centre, Department of Clinical Veterinary Science, Division of Companion Animals, University of Bristol, Langford, Bristol BS40 5DU, UK. s.taylor@bristol.ac.uk
authors.forename: Samantha S
authors.initials: SS
authors.lastname: Taylor
authors.forename: Simon W
authors.initials: SW
authors.lastname: Tappin
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Dodkin
authors.forename: Kostas
authors.initials: K
authors.lastname: Papasouliotis
authors.forename: Domingo
authors.initials: D
authors.lastname: Casamian-Sorrosal
authors.forename: Séverine
authors.initials: S
authors.lastname: Tasker
mesh_terms: D000818:Animals; D001797:Blood Protein Electrophoresis / Q000662:veterinary*; D001798:Blood Proteins / Q000032:analysis*; D002371:Cat Diseases / Q000097:blood* / Q000175:diagnosis; D002415:Cats; D016766:Feline Infectious Peritonitis / Q000097:blood* / Q000175:diagnosis; D005260:Female; D008223:Lymphoma / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D008297:Male; D010265:Paraproteinemias / Q000662:veterinary; D010954:Plasmacytoma / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D012016:Reference Values; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D005719:gamma-Globulins