title: IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy.
abstract: We report a patient with anti-myelin-associated glycoprotein (MAG) neuropathy, predominantly exhibiting severe motor symptoms, accompanied by extensive muscle atrophy mimicking Charcot-Marie-Tooth disease. Nerve conduction studies revealed mild retardation of motor conduction velocities and significant prolongation of distal latency. Sural nerve biopsy revealed widely spaced myelin and positive staining of myelinated fibers with an IgM antibody. Predominant motor symptoms with muscle atrophy can be one of the clinical manifestations of anti-MAG neuropathy.
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kawagashira
authors.forename: Naohide
authors.initials: N
authors.lastname: Kondo
authors.forename: Naoki
authors.initials: N
authors.lastname: Atsuta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iijima
authors.forename: Haruki
authors.initials: H
authors.lastname: Koike
authors.forename: Masahisa
authors.initials: M
authors.lastname: Katsuno
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tanaka
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000473:pathology; D003937:Diagnosis, Differential; D004568:Electrodiagnosis; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D035002:Lower Extremity / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D009431:Neural Conduction / Q000502:physiology; D010265:Paraproteinemias / Q000473:pathology* / Q000628:therapy
chemical_list: D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D018992:Myelin-Associated Glycoprotein