Highly enantioselective hydroaminoalkylation of secondary amines catalyzed by group 5 metal amides with chiral biarylamidate ligands.
A highly enantioselective group 5 metal amide catalyst system is reported for the hydroaminoalkylation of secondary amines to give chiral amines in good yields with excellent ee values (up to 93%) by loading of 5% precatalyst.
Zi
Guofu
G
Department of Chemistry, Beijing Normal University, Beijing 100875, China. gzi@bnu.edu.cn
Zhang
Furen
F
Song
Haibin
H
D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000577:Amides; D000588:Amines; D019216:Metals, Heavy; D009942:Organometallic Compounds