title: Competitive binding effects on surface-enhanced Raman scattering of peptide molecules.
abstract: Surface enhanced Raman scattering (SERS) has been conducted on tryptophan (W), proline (P) and tyrosine (Y) containing peptides that include W-P-Y, Y-P-W, W-P-P-P-Y, Y-P-P-P-W, W-P-P-P-P-P-Y, and Y-P-P-P-P-P-W to gain insight into molecular binding behavior on a metal substrate to eventually apply in protein SERS detection. The peptides are shown to bind through the molecule's carboxylic end, but the strong affinity of the tryptophan residue to the substrate surface, in conjunction with its large polarizability, dominates each molecule's SERS signal with the strong presence of its ring modes in all samples. These results are important for understanding SERS of protein molecules.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
authors.forename: Leo
authors.initials: L
authors.lastname: Seballos
authors.forename: Nicole
authors.initials: N
authors.lastname: Richards
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Stevens
authors.forename: Mira
authors.initials: M
authors.lastname: Patel
authors.forename: Laura
authors.initials: L
authors.lastname: Kapitzky
authors.forename: Scott
authors.initials: S
authors.lastname: Lokey
authors.forename: Glenn
authors.initials: G
authors.lastname: Millhauser
authors.forename: Jin Z
authors.initials: JZ
authors.lastname: Zhang