Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats.
The purpose of this study was to investigate whether bisphenol A (BPA), nonylphenol (NP) and octylphenol (OP) induce oxidative stress in the liver of male rats and co-administration of vitamin C can prevent any possible oxidative stress. Wistar male rats were divided into seven groups (vehicle, BPA, NP, OP, BPA+C, NP+C, OP+C). BPA, OP and NP groups (25 mg kg(-1)day(-1)) were administered orally to rats three times a week for 50 days. In BPA+C, NP+C, OP+C groups, vitamin C (60 mg kg(-1)day(-1)) was administered along with BPA, OP and NP (25 mg kg(-1)day(-1)) treatments. Aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS) were increased, glutathione (GSH) levels were decreased in treatment groups. AST, ALT, LDH and TBARS levels were increased whereas GSH levels were decreased in BPA+C, NP+C and OP+C groups compared to BPA, NP, and OP groups, respectively. Hepatic necrosis and congestion were observed in livers of rats treated. In conclusion, the present results demonstrate that BPA, NP, and OP cause oxidative damage by disturbing the balance between ROS and antioxidant defenses system in liver of male rats. Vitamin C co-administration along with BPA, NP, OP aggravates the damage in liver of male rats.
Korkmaz
Asli
A
Ministry of Agriculture and Rural Affairs, National Food Reference Laboratory, Fatih Sultan Mehmet Avenue, No 70, Yenimahalle, Postal Code 43, Ankara, Turkey.
Ahbab
Müfide Aydoğan
MA
Kolankaya
Dürdane
D
Barlas
Nurhayat
N
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001559:Benzhydryl Compounds; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D000098826:Bisphenol A Compounds
D000975:Antioxidants; D001205:Ascorbic Acid; D001559:Benzhydryl Compounds; D005978:Glutathione; D010636:Phenols; D017392:Thiobarbituric Acid Reactive Substances; C474055:octylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds