Therapeutic time window of low-frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats.
The present study was designed to determine whether low-frequency stimulation (LFS) of the entorhinal cortex(EC) has an anticonvulsive effect, and whether LFS delivered at different times plays different roles. We found that LFS of the EC immediately or 4 s after kindling stimulation had an anticonvulsive effect, and that the latter had a better effect on both kindling and kindled seizures. However, LFS delivered after the cessation of afterdischarge or 10 s after the kindling stimulation, augmented the epileptic activity. So the EC is a potential target for LFS to interfere with epilepsy. Our findings suggest that even in the duration of afterdischarge, there exists a "time window" for LFS treatment, indicating that the time delay of closed-loop stimulation is crucial for LFS treatment.
Xu
Zheng-Hao
ZH
Institute of Neuroscience, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Wu
Deng-Chang
DC
Fang
Qi
Q
Zhong
Kai
K
Wang
Shuang
S
Sun
Hong-Liu
HL
Zhang
Shi-Hong
SH
Chen
Zhong
Z
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D046690:Deep Brain Stimulation / Q000379:methods; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D004599:Electric Stimulation Therapy / Q000379:methods; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000706:statistics & numerical data; D018728:Entorhinal Cortex / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D007839:Functional Laterality / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology* / Q000517:prevention & control*; D013997:Time Factors