title: Novel diphenoxo-bridged dinuclear zinc complexes: generation of phenoxyl-radical species and nuclease activity.
abstract: Tridentate ligand PhimpH having N(2)O donors binds to zinc(II) after deprotonation, affording novel diphenoxo-bridged dinuclear zinc complexes [Zn(2)(Phimp)(2)(ClO(4))(2)] (1) and [Zn(2)(Phimp)(2)(Cl)(2)] x CH(2)Cl(2) (2 x CH(2)Cl(2)). The molecular structure of 2 x CH(2)Cl(2) revealed some unique structural features. The phenoxyl-radical complexes were generated at room temperature, and these radical complexes exhibited nuclease activity with pBR322 DNA.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. ghoshfcy@iitr.ernet.in
authors.forename: Kaushik
authors.initials: K
authors.lastname: Ghosh
authors.forename: Pramod
authors.initials: P
authors.lastname: Kumar
authors.forename: Nidhi
authors.initials: N
authors.lastname: Tyagi
authors.forename: Udai P
authors.initials: UP
authors.lastname: Singh
mesh_terms: D000818:Animals; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D056831:Coordination Complexes; D010636:Phenols; C042329:phenoxy radical; D004247:DNA; C427203:calf thymus DNA; D003851:Deoxyribonucleases; D015032:Zinc