title: Patterns of antibodies against latent and lytic antigens of human herpesvirus 8 in an endemic population and patients with Kaposi's sarcoma in Mozambique.
abstract: The patterns of antibodies against latent and lytic antigens of human herpesvirus 8 (HHV-8) were assessed using immunofluorescence assays of samples from 155 persons seropositive for HHV-8 seen at public health centers and 24 patients with Kaposi's sarcoma (KS) from Mozambique. Of the 155 persons without KS, 48 (31%) had antibodies against latent antigens only, 29 (18.7%) had antibodies against lytic antigens only, and 78 (50.3%) had antibodies against both types of antigen. The HHV-8 antibody titer tended to increase with age until age 40, after which it began to decrease. High titers of antibodies against latent and lytic antigens of HHV-8 were detected mostly in persons co-infected with HIV, and these increased titers could have a predictive value. All patients with KS except four patients who were seronegative for HHV-8 had elevated titers of HHV-8 antibodies, predominantly against latent antigens. The data suggest the potential for an increase in the development of KS in this endemic area for HHV-8.
authors.affiliation: Immunology Department, Instituto Adolfo Lutz, Secretary of Health of São Paulo, São Paulo, SP, Brazil. caterino@ial.sp.gov.br
authors.forename: Adele
authors.initials: A
authors.lastname: Caterino-de-Araujo
authors.forename: Mariana Cavalheiro
authors.initials: MC
authors.lastname: Magri
authors.forename: Rolanda Carmen Rafael
authors.initials: RC
authors.lastname: Manuel
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology*; D050976:Basic-Leucine Zipper Transcription Factors / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009073:Mozambique / Q000453:epidemiology; D009687:Nuclear Proteins / Q000276:immunology*; D012097:Repressor Proteins / Q000276:immunology*; D012514:Sarcoma, Kaposi / Q000097:blood / Q000453:epidemiology* / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D050976:Basic-Leucine Zipper Transcription Factors; C118265:K8 protein, Human herpesvirus 8; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014764:Viral Proteins; C109540:latency-associated nuclear antigen