title: Tribulus terrestris-induced severe nephrotoxicity in a young healthy male.
abstract: Herbal medications are being progressively utilized all over the world. Nevertheless, herbal remedies are not without hazards and several cases of adverse reactions have been described. Tribulus terrestris is traditionally used because of its aphrodisiac and antiurolithiatic activities with almost complete inhibition of stone formation. We report a case of T. terrestris-induced hepatotoxicity, nephrotoxicity and neurotoxicity in an Iranian male patient who used the plant's extract to prevent kidney stone formation. He presented with seizure and very high serum aminotransferases and creatinine after consuming herbal water for 2 days. Discontinuation of the herbal remedy resulted in improvement in symptoms and normalization of his liver enzymes.
authors.affiliation: Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Azita Hajhossein
authors.initials: AH
authors.lastname: Talasaz
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Abbasi
authors.forename: Saeed
authors.initials: S
authors.lastname: Abkhiz
authors.forename: Simin
authors.initials: S
authors.lastname: Dashti-Khavidaki
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003404:Creatinine / Q000097:blood; D006801:Humans; D008297:Male; D032444:Tribulus / Q000633:toxicity*
chemical_list: D003404:Creatinine