Evaluation of glycofurol-based gel as a new vehicle for topical application of naproxen.
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property, spreadability, and viscosity for topical anti-inflammatory effect. Three gelling and adhesive agents were examined: Carbopol 974P, Gantrez AN 119, and polyvinylpyrollidone K30. Skin permeation rates and lag times of NAP were evaluated using the Franz-type diffusion cell in order to optimize the gel formulation. The permeation rate of NAP-based gel across the excised rat skin was investigated. A significant increase in permeability parameters such as steady-state flux (J(ss)), permeability coefficient (K(p)), and penetration index (PI) was observed in optimized formulation containing 2% Transcutol as an permeation enhancer. From skin irritation test, it was concluded that the optimized novel glycofurol-based gel formulation was safe to be used for topical drug delivery. The developed glycofurol-based gel appeared promising for dermal and transdermal delivery of naproxen and could be applicable with water-insoluble drugs, which would circumvent most of the problems associated with drug therapy.
Barakat
Nahla Salah
NS
Department of Pharmaceutics, King Saud University, College of Pharmacy, PO Box 22452, Riyadh, 11495, Kingdom of Saudi Arabia. nsybarakat@yahoo.com
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D001458:Bandages; D004058:Diffusion; D004353:Drug Evaluation, Preclinical; D005782:Gels / Q000737:chemistry; D008297:Male; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000138:chemical synthesis*; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D009288:Naproxen; C018557:glycofurol