title: [XE-2100: platelet clumps or polymorphonuclear neutrophil aggregates, that is the question].
abstract: Leukoagglutination of polymorphonuclear neutrophils is described as a rare phenomenon but its incidence is certainly underestimated. We report here 4 cases showing why this phenomenon is sometimes difficult to detect. In each case, the only flag reported from the hematology analyser XE-2100 (Sysmex corporation) was 'Platelet clumps?'. The graphic patterns were not suggestive of leukoagglutination but rather evoked platelet clumps. The 4 white blood cell differential scattergrams were absolutely normal and the 4 cases were not associated with leukoneutropenia. Two patients had clumps located only at the edges of the smears, and automated imaging processes, scanning only the center of the smears, may also contribute to the failure of recognising this phenomenon.
authors.affiliation: Laboratoire d'hématologie, CHU de Clermont-Ferrand. fdubois-galopin@chu-clermontferrand.fr
authors.forename: Frédérique
authors.initials: F
authors.lastname: Dubois-Galopin
authors.forename: Florence
authors.initials: F
authors.lastname: Lamballais
authors.forename: Chantal
authors.initials: C
authors.lastname: Rapatel
authors.forename: Marc Gabriel
authors.initials: MG
authors.lastname: Berger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000097:blood; D001331:Automation; D001399:Azure Stains; D002449:Cell Aggregation; D005260:Female; D006386:Hemagglutination Tests / Q000379:methods*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000097:blood; D010976:Platelet Count / Q000379:methods*; D012016:Reference Values
chemical_list: D001399:Azure Stains