title: Genetic aspects of non-polypoid colorectal neoplasms.
abstract: Colorectal cancer is a heterogeneous disease arising through multiple possible pathways. Elucidating the genetic factors controlling molecular phenotype, morphology, histology, and prognosis of different tumor types continues to be a challenge. Non-polypoid colorectal neoplasms provide opportunities for ongoing study of their underlying genetic abnormalities and molecular phenotypes. The varied data from different groups, however, highlight the need for further studies in different populations.
authors.affiliation: Section of Digestive Diseases and Nutrition, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, IL 60612, USA. lynsue@uic.edu
authors.forename: Lyn Sue
authors.initials: LS
authors.lastname: Kahng
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D053842:Microsatellite Instability; D008967:Molecular Biology; D010641:Phenotype; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras); D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D018631:ras Proteins / Q000235:genetics
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins