title: Optic neuritis.
abstract: Optic neuritis usually presents with painful monocular vision loss in younger patients. Spontaneous improvement in vision occurs over weeks, and treatment with high-dose intravenous steroids increases the rate but not extent of visual recovery. Risk of progression to multiple sclerosis (MS) is largely dictated by baseline brain magnetic resonance imaging (MRI). Those with a normal MRI finding at the time of optic neuritis diagnosis have a lower rate of progression to multiple sclerosis than those with T2 hyperintense white matter lesions on MRI. High-dose intravenous steroids should be considered acutely in optic neuritis, and disease-modifying therapy should be considered in patients at high risk of MS as defined by MRI.
authors.affiliation: Department of Neurology and Ophthalmology, Michigan State University, A217 Clinical Center, 138 Service Road, East Lansing, MI 48824, USA. david.clark@hc.msu.edu
authors.forename: David
authors.initials: D
authors.lastname: Clark
authors.forename: Workayehu
authors.initials: W
authors.lastname: Kebede
authors.forename: Eric
authors.initials: E
authors.lastname: Eggenberger
mesh_terms: D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009103:Multiple Sclerosis / Q000150:complications; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D011241:Prednisone / Q000008:administration & dosage
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone