Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?
The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.
Kren
Leos
L
Department of Pathology, University Hospital Brno, Brno, Czech Republic. lkren@fnbrno.cz
Slaby
Ondrej
O
Muckova
Katarina
K
Lzicarova
Eva
E
Sova
Marek
M
Vybihal
Vaclav
V
Svoboda
Tomas
T
Fadrus
Pavel
P
Lakomy
Radek
R
Vanhara
Petr
P
Krenova
Zdenka
Z
Sterba
Jaroslav
J
Smrcka
Martin
M
Michalek
Jaroslav
J
D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D005909:Glioblastoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006680:HLA Antigens / Q000096:biosynthesis*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D046888:Tissue Array Analysis; D000097625:HLA-E Antigens
D014408:Biomarkers, Tumor; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens