Association between serum IGF-1 and diabetes among U.S. adults.
OBJECTIVE
Serum insulin-like growth factor (IGF)-1 may have a role in the maintenance of glucose homeostasis. We examined the association between serum IGF-1 and diabetes in a representative sample of U.S. adults.


METHODS
Third National Health and Nutrition Examination Survey (NHANES III) participants aged ≥ 18 years (n = 5,511) were the subjects of the study. The main outcome was the presence of diabetes (n = 387).


RESULTS
Lower serum IGF-1 levels were positively associated with diabetes after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, BMI, hypertension, glomerular filtration rate, and serum cholesterol. Compared with quartile 4 of IGF-1 (referent), the odds ratio (OR) of diabetes associated with quartile 1 was OR 2.16 (95% CI 1.24-3.76); P-trend = 0.002. However, the observed association between IGF-1 and diabetes was present only in those < 65 years of age (OR = 3.05; P-trend = 0.006) and disappeared in those ≥ 65 years of age (OR = 0.51; P-trend = 0.18); P-interaction = 0.0056.


CONCLUSIONS
Low IGF-1 levels are associated with diabetes among young subjects.
Teppala
Srinivas
S
Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Shankar
Anoop
A
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014481:United States
D007334:Insulin-Like Growth Factor I