title: Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography.
abstract: OBJECTIVE
  To study the correlation of liver and spleen volume with the degree of liver fibrosis and cirrhosis induced by hepatitis B virus infection.
  
  
  METHODS
  128 participants who had undergone liver and spleen volumetry were enrolled. The control group consisted of 41 participants who were potential living liver donors. The liver fibrosis group consisted of 63 histologically proved liver fibrosis patients who were further divided into two subgroups: 44 patients with slight liver fibrosis, and 19 patients with advanced liver fibrosis. The liver cirrhosis group consisted of 24 patients. The following parameters were determined by multi-detector spiral computed tomography (MSCT) examination: total liver volume (TLV), right liver lobe volume (RV), left lateral liver segment volume (LLV), left medial liver segment volume (LMV), caudate lobe volume (CV), and spleen volume (SV). The ratios of CV to TLV (C/T), RV to TLV (R/T), LLV to TLV (LL/T), LMV to TLV (LM/T), and SV to TLV (S/T) were calculated.
  
  
  RESULTS
  TLV, RV, LMV tended to decrease and SV, C/T, S/T tended to increase gradually with the increased degree of fibrosis. C/T >or= 3.34% and S/T >or= 47.36% were identified as the cut-off values of fibrosis >or=F3 (advanced liver fibrosis) and cirrhosis, respectively. Their sensitivities were 68.4% and 87.5% and their specificities were 59.1% and 89.5%, respectively.
  
  
  CONCLUSIONS
  Variations in liver and spleen volume correlated with the degree of liver fibrosis and cirrhosis and could be used in the non-invasive follow-up of the development of liver fibrosis.
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Wei Xia
authors.initials: WX
authors.lastname: Li
authors.forename: Xiang Tian
authors.initials: XT
authors.lastname: Zhao
authors.forename: Wei Min
authors.initials: WM
authors.lastname: Chai
authors.forename: Nai Yi
authors.initials: NY
authors.lastname: Zhu
authors.forename: Lian Jun
authors.initials: LJ
authors.lastname: DU
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Hua Wei
authors.initials: HW
authors.lastname: Ling
authors.forename: Ke Min
authors.initials: KM
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis*; D006529:Hepatomegaly / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013154:Spleen / Q000000981:diagnostic imaging* / Q000473:pathology*; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000473:pathology; D036542:Tomography, Spiral Computed / Q000379:methods; D055815:Young Adult