title: Bronchial reactivity in schoolchildren allergic to food.
abstract: BACKGROUND
  Food allergy (FA) is associated with an increased risk of asthma.
  
  
  OBJECTIVE
  To evaluate whether bronchial hyperreactivity (BHR) occurs in children with FA depending on the presence of respiratory symptoms.
  
  
  METHODS
  Fifty-four children with FA and 62 without FA were studied for BHR, defined as a provocation concentration of methacholine that caused a decrease in forced expiratory volume in 1 second of 20% (PC20). The diagnosis of FA was established using questionnaires, clinical criteria, skin prick tests, serum specific IgE antibodies, and a double-blind placebo-controlled food challenge.
  
  
  RESULTS
  Among nonasthmatic children, BHR was diagnosed in 15 (47%) with FA and in 7 (17%) without FA (P < .005); BHR was demonstrated in 7 children (41%) with FA alone. All the patients with asthma with or without FA had BHR. The mean (SD) PC20 in children with FA alone was 2.8 [1.38] mg/mL and was significantly higher than that in children with asthma alone (0.88 [1.01] mg/mL) or with asthma and FA (0.96 [0.83] mg/mL) (P < .001). BHR was detected in 5 children (36%) with a mild anaphylactic reaction provoked by food, in 23 (74%) with a moderate reaction, and in all the children with a severe reaction.
  
  
  CONCLUSIONS
  Children with FA had increased BHR independent of respiratory symptoms. Although BHR occurs in asymptomatic children with FA, its course is milder than that in children with FA and asthma. Factors that determine BHR prevalence in children with FA are similar to those in children without FA.
authors.affiliation: Department of Pediatric Allergology, Gastroenterology, and Nutrition, Medical University of Lodz, Lodz, Poland. anetkrog@poczta.onet.pl
authors.forename: Aneta
authors.initials: A
authors.lastname: Krogulska
authors.forename: Jarosław
authors.initials: J
authors.lastname: Dynowski
authors.forename: Krystyna
authors.initials: K
authors.lastname: Wasowska-Królikowska
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D002648:Child; D018450:Disease Progression; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012307:Risk Factors; D012574:Schools; D012882:Skin Tests; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens; D007073:Immunoglobulin E