title: Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays.
abstract: Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.
authors.affiliation: Institute of Microelectronics, A*STAR (Agency for Science, Technology and Research), 11 Science Park Road, 117685 Singapore.
authors.forename: Tze-Sian
authors.initials: TS
authors.lastname: Pui
authors.forename: Ajay
authors.initials: A
authors.lastname: Agarwal
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Tou
authors.forename: Yinxi
authors.initials: Y
authors.lastname: Huang
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002460:Cell Line; D057230:Limit of Detection; D051379:Mice; D046529:Microscopy, Electron, Transmission; D053770:Nanowires / Q000737:chemistry*; D012666:Semiconductors; D012825:Silicon / Q000737:chemistry*
chemical_list: D054392:Adipokines; D012825:Silicon