A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26.
Spontaneous tumors in dogs share many of the same features of their human orthologues including clinical behavior, response to treatment, and molecular defects. It is therefore natural to consider the use of dogs and their spontaneous malignancies in the study of complex disease such as cancer. Scottish Deerhounds are a giant breed of dogs that exhibit a high incidence of bone cancer. Our previous work suggested that osteosarcoma within this breed could be explained by the presence of a major gene of dominant effect. Herein, we use a whole genome mapping approach to evaluate a four-generation pedigree of Scottish Deerhounds for linkage of their osteosarcoma phenotype. Using this approach we found evidence of linkage (Z(max)=5.766) between their phenotype and markers located on CFA34, in a region syntenic to human chromosome 3q26. The identification of this locus provides novel insight into the genetic basis of osteosarcoma in both canines and humans.
Phillips
Jeffrey C
JC
College of Veterinary Medicine, Department of Small Animal Clinical Sciences, 2407 River Drive, C247 Veterinary Teaching Hospital, Knoxville, TN 37996-4544, USA. jphill35@utk.edu
Lembcke
Luis
L
Chamberlin
Tamara
T
D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D008040:Genetic Linkage; D056426:Genetic Loci / Q000502:physiology; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000235:genetics*; D010375:Pedigree; D017385:Sequence Homology