title: Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein.
abstract: Design of inhibitors of P-glycoprotein still represents a challenging task for medicinal chemists. The polyspecificity of the transporter combined with the limited structural information renders rational drug design approaches rather ineffective. Within this article we will exemplify how recent insights into structure and mechanism of P-glycoprotein may aid in design of potent inhibitors.
authors.affiliation: University of Vienna, Department of Medicinal Chemistry, Althanstrasse 14, 1090 Wien, Austria.
authors.forename: Freya
authors.initials: F
authors.lastname: Klepsch
authors.forename: Thomas
authors.initials: T
authors.lastname: Stockner
authors.forename: Thomas
authors.initials: T
authors.lastname: Erker
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Peter
authors.initials: P
authors.lastname: Chiba
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Ecker
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents