Configurationally labile enantioenriched lithiated 3-arylprop-2-enyl carbamates: joint experimental and quantum chemical investigations on the equilibrium of epimers.
Experimental investigations as well as high-level quantum chemical calculations are performed on the two epimeric pairs of complexes 4.2 and 6.2 obtained by lithiation of cinnamyl carbamate (1) and 1-naphthyl derivative 5 in the presence of BOX ligands (S,S)- and (R,R)-2. Indeed, in the case of configurationally labile complexes and a dynamic thermodynamic resolution, which is found to take place, one of both epimers is energetically favored. The quantum chemical computations allow the prediction of the enantiomeric excess that can be expected.
Hémery
Thérèse
T
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Germany.
Huenerbein
Robert
R
Fröhlich
Roland
R
Grimme
Stefan
S
Hoppe
Dieter
D
D002219:Carbamates / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008094:Lithium / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011789:Quantum Theory; D013237:Stereoisomerism
D002219:Carbamates; D009942:Organometallic Compounds; D008094:Lithium