Validation of simple and robust protocols for high-resolution lung proton MRI in mice.
One fundamental limitation of spatial resolution for in vivo MR lung imaging is related to motion in the thoracic cavity. To overcome this limitation, several methods have been proposed, including scan-synchronous ventilation and the cardiac gating approach. However, with cardiac and ventilation triggered techniques, the use of a predetermined and constant sequence repetition time is not possible, resulting in variable image contrast. In this study, the potential of two "constant repetition time" approaches based on retrospective self-gating and signal averaging were investigated for lung imaging. Image acquisitions were performed at a very short echo time for visualization of the lung structures and the parenchyma. Highly spatially resolved images acquired using retrospective self-gating, signal averaging technique and conventional cardiorespiratory gating are presented and compared.
Zurek
Magdalena
M
Université de Lyon, Lyon, France.
Bessaad
Amine
A
Cieslar
Katarzyna
K
Crémillieux
Yannick
Y
D000465:Algorithms; D000818:Animals; D016477:Artifacts; D005260:Female; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D011522:Protons; D015203:Reproducibility of Results; D055425:Respiratory-Gated Imaging Techniques / Q000379:methods*; D012680:Sensitivity and Specificity
D011522:Protons