Novel flavonoids from the leaves of Actinidia valvata Dunn: structural elucidation and antioxidant activity.
Two novel flavonoids, kaempferol 3- O- α-L-rhamnopyranosyl (1-3) (2,4-di- O-acetyl-α-L-rhamnopyranosyl) (1-6) β-D-galactopyranoside (1) and kaempferol 3- O-α-L-rhamnopyranosyl (1-3) (4-O-acetyl-α-L-rhamnopyranosyl) (1-6) β-D-galactopyranoside (2), along with three known ones, kaempferol-3- O-β-D-galactopyranoside (3), kaempferol (4), and 7-hydroxychromone (5), have been isolated from the leaves of Actinidia valvata Dunn, and their structures were elucidated based on spectroscopic methods. Compounds 1-3 exhibited dose-dependent activity in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, superoxide anion radicals, and hydroxyl radicals, and inhibited lipid peroxidation of mouse liver homogenate IN VITRO.
Xin
Hai-Liang
HL
Department of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, PR China.
Wu
Ying-Chun
YC
Su
Yong-Hua
YH
Sheng
Jia-Yu
JY
Ling
Chang-Quan
CQ
D029042:Actinidia / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids