title: Artemisinins and the biological basis for the PfATP6/SERCA hypothesis.
abstract: With the advent of artemisinin resistance, it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs). Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.
authors.affiliation: Centre for Infection, Cellular and Molecular Medicine, St. George's University of London, Cranmer Terrace, London, UK, SW17 0RE. s.krishna@sgul.ac.uk
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Krishna
authors.forename: Serena
authors.initials: S
authors.lastname: Pulcini
authors.forename: Farrah
authors.initials: F
authors.lastname: Fatih
authors.forename: Henry
authors.initials: H
authors.lastname: Staines
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000187:drug effects*; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors* / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases