title: Reduction of contrast material volume in 3D angiography of the brain using MDCT.
abstract: OBJECTIVE
  Our aim was to investigate the image quality of MDCT angiography of the brain at a low-volume of contrast material.
  
  
  METHODS
  One hundred patients were randomly assigned to one of two groups, which differed with regard to contrast material volume and subsequent saline bolus: group A was administered 300 mg I/mL, 50 mL at an injection rate of 3.0 mL/s followed by a 20-mL saline bolus at 3.0 mL/s; group B was administered 300 mg I/mL, 100 mL at 3.0 mL/s. Of 100 total patients, 82 were analyzed: 45 in group A and 37 in group B. The attenuation and visualization of intracranial arteries were compared between the two groups. The regions of interest (ROIs) were drawn throughout the data set: internal carotid artery (ROI 1), anterior cerebral artery (ROI 2), middle cerebral artery (ROI 3), vertebral artery (ROI 4), basilar artery (ROI 5), and posterior cerebral artery (ROI 6). The differences were assessed with a Student's t test. Two readers evaluated images and graded vascular delineation of intracranial arteries by consensus.
  
  
  RESULTS
  Eighty-two patients were investigated strictly according to the study protocol and were included in the per-protocol population. There were no statistically significant differences between the two groups in average attenuation (p = 0.21) and visual analysis (p = 0.84).
  
  
  CONCLUSIONS
  When performing 3D angiography of the brain using 16-MDCT, the use of a 20-mL saline flush allows reduction of contrast material from 100 mL to 50 mL if all other factors are unchanged.
authors.affiliation: Department of Diagnostic Radiology, Kumamoto University, Kumamoto-shi, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tamura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Utsunomiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hirai
authors.forename: Taiji
authors.initials: T
authors.lastname: Nishiharu
authors.forename: Joji
authors.initials: J
authors.lastname: Urata
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D002533:Cerebral Angiography / Q000187:drug effects* / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging*; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol