title: Cavernous lymphangiomas involving bilateral labia minora.
abstract: BACKGROUND
  The vulva is an extremely rare site for lymphangioma, a benign tumor of the lymphatic vessels. A small number of case reports have described cavernous lymphangioma involving the unilateral labium majus of young women. We report a case of cavernous lymphangiomas involving the bilateral labia minora.
  
  
  METHODS
  A 14-year-old girl presented with bilateral tumors of the labia minora, which were removed surgically and histologically diagnosed as cavernous lymphangioma. Positive nuclear staining for estrogen and progesterone receptors was demonstrated in the stromal fibroblasts immunohistochemically.
  
  
  CONCLUSIONS
  It is suggested that an increase in estrogen and progesterone levels may have led to, or at least affected, the development of these tumors in this patient. Excision followed by cosmetic repair may be the optimal treatment.
authors.affiliation: From the Departments of Obstetrics and Gynecology, Pathology, and Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsubara
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamanaka
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D008202:Lymphangioma / Q000175:diagnosis / Q000601:surgery*; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000601:surgery*