title: Diabetic keto-acidosis as a presentation of cystic fibrosis-related diabetes: a case report.
abstract: Cystic fibrosis (CF) is one of the most common genetically inherited diseases and often complicated by diabetes mellitus. With increasing longevity, the incidence and prevalence of cystic fibrosis-related diabetes (CFRD) rise and microvascular complications develop. CFRD is an entity on its own with characteristics seen in both type 1 and type 2 diabetes. Keto-acidosis, a potentially life-threatening complication of diabetes, is an extremely rare presentation of CFRD. Here we present the history of a 21-year-old CF patient with no prior diagnosis of CFRD who developed keto-acidosis after an episode of pulmonary infection. Based on this case report we would like to emphasize the importance of screening for and early treatment of CFRD. We also discuss the management policy of CFRD and when and whether to initiate insulin therapy.
authors.affiliation: Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium.
authors.forename: Vera
authors.initials: V
authors.lastname: Eenkhoorn
authors.forename: Annelies
authors.initials: A
authors.lastname: Van den Driessche
authors.forename: Luc
authors.initials: L
authors.lastname: Van Gaal
authors.forename: Kristine
authors.initials: K
authors.lastname: Desager
authors.forename: Christophe
authors.initials: C
authors.lastname: De Block
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D048909:Diabetes Complications / Q000175:diagnosis* / Q000628:therapy; D016883:Diabetic Ketoacidosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin