[The bioamine profile of the lens during the development of different types of human age-related cataract].
Luminescence microscopy of cryostat sections of lenses and spectrofluorometry were used to study the lens in health and in different types of human age-related cataract. The cortical type of age-related cataract occurs with the considerably increased concentrations of histamine, catecholamines and serotonin. Examination of the bioamine profile of age-related nuclear cataract revealed a significant increase in the level of serotonin and a moderate rise in the concentration of catecholamines. At the same time, the values of histamine did not practically differ from those in the intact lens. Thus, principal differences were found in the bioamine provision of the development of age-related cortical and nuclear cataract, suggesting that it is necessary to elaborate a differential approach to studying the pathogenetic mechanisms and treatments for human age-related cataract depending on its specific type.
Korsakova
N V
NV
Sergeeva
V E
VE
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D001679:Biogenic Amines / Q000032:analysis / Q000378:metabolism*; D002386:Cataract / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007908:Lens, Crystalline / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D001679:Biogenic Amines