title: Herpes zoster ophthalmicus and HIV seropositivity in South-south Nigeria.
abstract: BACKGROUND
  Herpes zoster is a painful vesiculobullous dermatitis which occurs as a result of previously established varicella zoster virus infection. It is a well established fact that Herpes zoster ophthalmicus is a well known marker of human immune deficiency virus infection even in Africans. The aim of this study is to determine if indeed the herpes zoster condition is a marker for the immune deficiency condition called AIDS in our locality and whether the positivityis related to age or not.
  
  
  METHODS
  A total of 20 consecutive patients that presented between 2003 and 2006 with herpes zoster ophthalmicus were examined retrospectively as to their Human Immune deficiency virus (HIV) status. Their presentation, clinical findings and clinical course are also analyzed.
  
  
  RESULTS
  Of the 20 patients examined there was a male preponderance of 4:3 with most patients above 40 years (35.4% between 41-50 years) and half of them were married. Out of the twelve (n = 12, 60%) patients whose serum was tested for human immunodeficiency virus, eight (n = 8, 40%) were negative, while four (n = 4, 20%) were positive for the virus. Eight were not tested. Using 40 years of age as the cutoff, those above 40 years (12 in number), two (n = 2, 25%) were seropositive while 9 were negative (75%). For those below 40 years (8 in number), two (n = 2, 25%) were positive while six were negative (75%). Upon treatment with antivirals (Zovirax) in the majority of cases there was complete resolution in 8 (57%) of the patients with most of the sequelae occurring in those of them who are seropositive.
  
  
  CONCLUSIONS
  Correlation of impaired immune status with Herpes zoster affectation was found to be more obvious in the younger than 40 years group. Treatment with antivirals gave good resolution in most cases. Blinding complications were found more in those who were seropositive.
authors.affiliation: Department of Ophthalmology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers Nigeria. drdayoadio@yahoo.com
authors.forename: A O
authors.initials: AO
authors.lastname: Adio
authors.forename: B
authors.initials: B
authors.lastname: Fiebai
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D000212:Acyclovir / Q000627:therapeutic use*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006679:HIV Seropositivity / Q000150:complications* / Q000821:virology; D006563:Herpes Zoster Ophthalmicus / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D012189:Retrospective Studies; D017678:Sex Distribution; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir