Reticulated myxoid tumor of the tongue: 2 cases supporting an expanded clinical and immunophenotypic spectrum of ectomesenchymal chondromyxoid tumor of the tongue.
An ectomesenchymal chondromyxoid tumor (ECMT) is a rare neoplasm that exclusively occurs in the anterior dorsum of the tongue. The tumor consists of small round to fusiform or spindle cells with myxoid or chondroid stroma. The tumor consistently shows a positive reaction with glial fibrillary acidic protein antibodies, especially polyclonal antibodies. We report 2 cases of reticulated myxoid tumors arising in the tongue. One tumor occurred in the posterior dorsum of the tongue and another in the anterior. Both tumors showed characteristic morphology of ECMT; however, both were negative for reactions with monoclonal and polyclonal glial fibrillary acidic protein antibodies. On the basis of morphology, they are thought to be belonging to ECMT. Hence, we suggest that ECMT can show broader spectrum of clinical and immunophenotypic feature.
Seo
Sang Hee
SH
Departments of Dermatology, Pusan National University School of Medicine, Yangsan-si, Kyeongsangnam-do, Korea.
Shin
Dong Hoon
DH
Kang
Hyun Jeong
HJ
Choi
Kyung Un
KU
Kim
Jee Yeon
JY
Park
Do Youn
DY
Lee
Chang Hun
CH
Sol
Mee Young
MY
Lee
Jin Choon
JC
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D009232:Myxoma / Q000378:metabolism / Q000473:pathology*; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein