title: [Duodenal villous atrophy associated with Mycophenolate mofetil: report of one case].
abstract: Mycophenolate mofetil (MMF) is an immunosupressor agent frequently used in patients after bone marrow or solid organ transplants. The most common adverse reactions of the drug are gastrointestinal, specially diarrhea and vomiting. We report a 53-year-old male, that received a heart transplant receiving immunosuppression with cyclosporine, mycophenolate mofetil and prednisone. Six months after the transplant, the patient started with diarrhea, anorexia and weight loss. A duodenal biopsy showed villous atrophy. Celiac disease and the presence of parasites were discarded. Mycophenolate mofetil was discontinued and one week later, diarrhea subsided. Two months later the patient was asymptomatic and recovered weight. A new duodenal biopsy showed absence of villous atrophy.
authors.affiliation: Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de la Frontera, Temuco, Chile. otescalona@gmail.com
authors.forename: Oscar
authors.initials: O
authors.lastname: Tapia
authors.forename: Miguel
authors.initials: M
authors.lastname: Villaseca
authors.forename: Armando
authors.initials: A
authors.lastname: Sierralta
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Roa
mesh_terms: D001284:Atrophy; D001706:Biopsy; D004386:Duodenum / Q000473:pathology*; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008871:Microvilli / Q000473:pathology*; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid