title: Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis.
abstract: Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75-1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.
authors.affiliation: Department of Radiation Oncology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea.
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Yang
authors.forename: Kyong Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Ok Hee
authors.initials: OH
authors.lastname: Woo
authors.forename: Sang Uk
authors.initials: SU
authors.lastname: Woo
authors.forename: Ae-Ree
authors.initials: AR
authors.lastname: Kim
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Lee
authors.forename: Jae-Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Seo
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015233:Models, Statistical; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A