[Growth differentiation factor 15--a new marker in heart diseases].
Growth differentiation factor-15 (GDF-15) is a cytokine with cardioprotective properties, which inhibits hypertrophy, cardiac remodeling and apoptosis. Participates in the life and cell death. The concentration of GDF-15 rapidly increases under the influence of ischemia-reperfusion damage to heart muscle, oxidative stress, inflammatory cytokines and pressure overload. In patients with acute coronary syndromes, heart failure and pulmonary embolism provides independent prognostic information, both short-and long-term. It is potentially a new marker of risk stratification in patients with heart disease and therapeutic decision making.
Olechnicki
Maciej
M
10 Wojskowy Szpital Kliniczny z Poliklinik. w Bydgoszczy, Klinika Kardiologii, Oddział Kardiologii Inwazyjnej.
Kasprzak
Krzysztof
K
Goch
Aleksander
A
D015415:Biomarkers / Q000378:metabolism; D055436:Growth Differentiation Factor 15 / Q000378:metabolism*; D006331:Heart Diseases / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D018570:Risk Assessment / Q000379:methods
D015415:Biomarkers; D055436:Growth Differentiation Factor 15