A trimethoxyellagic acid glucuronide from Conocarpus erectus leaves: isolation, characterization and assay of antioxidant capacity.
The new trimethoxy-ellagic glycoside, 3,3',4'-tri-O-methylellagic acid 4-O-beta-glucupyranuronide and twelve known phenolics were isolated from the leaves of Conocarpus erectus L. (Combretaceae). Structures of all compounds were determined on the basis of spectroscopic methods and chemical degradation. The new compound, together with four of the isolated known constituents and the plant extract itself, showed potent inhibitory effect against reactive oxygen species attack on salicylic acid in a dose-dependent manner adopting xanthine/hypoxanthine oxidase assay.
Ayoub
Nahla A
NA
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Cairo, Egypt. ayoub.n@link.net
D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D029764:Combretaceae / Q000737:chemistry*; D004534:Egypt; D004610:Ellagic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D020719:Glucuronides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D016488:Medicine, African Traditional; D015394:Molecular Structure; D009994:Osmolar Concentration; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D020156:Salicylic Acid / Q000737:chemistry / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D014969:Xanthine Oxidase / Q000378:metabolism
C553569:3,3',4'-tri-O-methylellagic acid 4-O-beta-glucupyranuronide; D000975:Antioxidants; D005419:Flavonoids; D020719:Glucuronides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D004610:Ellagic Acid; D014969:Xanthine Oxidase; D020156:Salicylic Acid