Cell survival and redistribution after transplantation into damaged myocardium.
A hybrid approach to support cell survival and decrease cell escape Cell transplantation has become an attractive option for cardiac regenerative therapy. However, poor cell survival and extensive redistribution throughout the body can drastically affect the outcome and safety of cell therapy. Although various approaches have been attempted to support the survival and engraftment of implanted cells, we need to apply a new comprehensive strategy by melding the in vitro and in vivo approaches to recondition the cells and infarcted myocardium. Here we summarize our understanding of cell survival and migration after transplantation into the damaged heart.
Zhang
Hao
H
Department of Cardiac Surgery, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Chen
Haibo
H
Wang
Wei
W
Wei
Yingjie
Y
Hu
Shengshou
S
D000818:Animals; D002465:Cell Movement; D002470:Cell Survival; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D033581:Stem Cell Transplantation; D016896:Treatment Outcome