Catalytic asymmetric epoxidation of alpha-branched enals.
An asymmetric catalytic epoxidation of alpha-branched, alpha,beta-unsaturated aldehydes is presented. A highly synergistic combination of a primary cinchona-based amine and a chiral phosphoric acid was found to promote the reaction with excellent enantiocontrol for alpha-monosubstituted and alpha,beta-disubstituted enals.
Lifchits
Olga
O
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany.
Reisinger
Corinna M
CM
List
Benjamin
B