Epigenetics and child health: basic principles.
Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic plasticity. The knowledge upon which these claims are based is beginning to expand. This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health.
Groom
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A
Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, UK.
Elliott
H R
HR
Embleton
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ND
Relton
C L
CL
D002648:Child; D002657:Child Development / Q000502:physiology*; D019175:DNA Methylation / Q000235:genetics; D004777:Environment; D044127:Epigenesis, Genetic / Q000235:genetics*; D057890:Epigenomics / Q000379:methods; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D020022:Genetic Predisposition to Disease; D016678:Genome; D006801:Humans; D010641:Phenotype