Role of CD8 T-cell-mediated autoimmune diseases of the central nervous system.
In T-cell-mediated autoimmune diseases of the central nervous system (CNS), CD4 T cells have long been regarded as the only pathogenetically relevant T-cell population. However, growing clinical and experimental evidence suggests that CD8 T cells also contribute significantly to autoimmune responses in the CNS. We discuss the potential induction of autoimmune CD8 T cells by infections, the impact of the microenvironment of the CNS on CD8 T-cell responses, and the potential interaction of CD8 T cells with autoantigen-expressing resident brain-cell populationsneurons in particularin light of clinical and experimental findings.
Deckert
Martina
M
Abteilung für Neuropathologie, Universitätsklinikum Köln, Germany. neuropatho@uni-koeln.de
Sanchez-Ruiz
Monica
M
Brunn
Anna
A
Schluter
Dirk
D
D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D018716:Molecular Mimicry
D018984:Epitopes, T-Lymphocyte