Effects of regular and low-fluoride dentifrices on plaque fluoride.
Previous studies have indicated that the use of low-fluoride dentifrices could lead to proportionally higher plaque fluoride levels when compared with conventional dentifrices. This double-blind, randomized, crossover study determined the effects of placebo, low-fluoride, and conventional dentifrices on plaque fluoride concentrations ([F]) in children living in communities with 0.04, 0.72, and 3.36 ppm F in the drinking water. Children used the toothpastes twice daily, for 1 wk. Samples were collected 1 and 12 hrs after the last use of dentifrices and were analyzed for fluoride and calcium. Similar increases were found 1 hr after the children brushed with low-fluoride (ca. 1.9 mmol F/kg) and conventional (ca. 2.4 mmol F/kg) dentifrices in the 0.04- and 0.72-ppm-F communities. Despite the fact that the increases were less pronounced in the 3.36-ppm-F community, our results indicate that the use of a low-fluoride dentifrice promotes a proportionally higher increase in plaque [F] when compared with that achieved with a conventional dentifrice, based on dose-response considerations.
Pessan
J P
JP
Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, São Paulo State University (UNESP), Araçatuba, SP, Brazil.
Alves
K M R P
KM
Ramires
I
I
Taga
M F L
MF
Sampaio
F C
FC
Whitford
G M
GM
Buzalaf
M A R
MA
D002118:Calcium / Q000032:analysis; D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D002648:Child; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000737:chemistry*; D003802:Dentifrices / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005459:Fluorides / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D006801:Humans; D010919:Placebos; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014099:Toothbrushing; D014881:Water Supply / Q000032:analysis
D002327:Cariostatic Agents; D003802:Dentifrices; D010919:Placebos; D005459:Fluorides; D002118:Calcium