The chemical constituents of endophytic fungus Trichoderma sp. MFF-1.
A fungal strain named MFF-1 was isolated from the flower of Pyrethrum cinerariifolium. Based on the sequence at the internal transcribed spacer (ITS) region, this strain was identified as a Trichoderma sp. Two new compounds, including a mitorubrin derivative and its potential biogenetic precursor, together with a known compound, were isolated from the cultures of the endophytic fungus. Their structures were established by spectroscopic methods and determined to be (3S*,6R*,7R*)-3,4,5,6,7,8-hexahydro-7-hydroxy-7-methyl-8-oxo-3-[(E)-prop-1-enyl]-1H-isochromen-6-yl 2,4-dihydroxy-6-methylbenzoate (1), named deacetylisowortmin, (E)-2-(hydroxymethyl)-3-(2-hydroxypent-3-enyl)phenol (2), and wortmannin (3). All compounds were assayed for antimicrobial activity. Compound 3 showed activity against Candida albicans and Bacillus cereus.
Li
Guo-Hong
GH
Laboratory for Conservation and Utilization of Bio-resources, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, P. R. China.
Wang
Xing-Biao
XB
Liu
Fang-Fang
FF
Dang
Li-Zhi
LZ
Li
Lei
L
Yang
Zhong-Shan
ZS
Xin
Xiong
X
Zhang
Ke-Qin
KQ
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D011723:Chrysanthemum cinerariifolium / Q000469:parasitology*; D035264:Flowers / Q000469:parasitology; D008826:Microbial Sensitivity Tests; D014242:Trichoderma / Q000737:chemistry* / Q000302:isolation & purification
D000890:Anti-Infective Agents; D001565:Benzoates; C521221:mitorubrin