title: Aneuploidies in embryos and spermatozoa from patients with Y chromosome microdeletions.
abstract: In patients with Y chromosome microdeletions and high percentage of numeric chromosome abnormalities detected by fluorescence in situ hybridization on sperm, a high percentage of abnormal embryos was observed compared with oligozoospermic patients without Y chromosome microdeletions, with a significant increase in the percentage of embryos with monosomy X. Differences in fertilization rates between the different patient groups were not observed; however, blastocyst rates were significantly impaired in patients with Y chromosome microdeletions.
authors.affiliation: Instituto Valenciano de Infertilidad, Valencia, Spain. emateu@ivi.es
authors.forename: Emilia
authors.initials: E
authors.lastname: Mateu
authors.forename: Lorena
authors.initials: L
authors.lastname: Rodrigo
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Martínez
authors.forename: Vanessa
authors.initials: V
authors.lastname: Peinado
authors.forename: Miguel
authors.initials: M
authors.lastname: Milán
authors.forename: Manuel
authors.initials: M
authors.lastname: Gil-Salom
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Martínez-Jabaloyas
authors.forename: José
authors.initials: J
authors.lastname: Remohí
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
authors.forename: Carmen
authors.initials: C
authors.lastname: Rubio
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics; D004622:Embryo, Mammalian / Q000002:abnormalities / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007248:Infertility, Male; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000235:genetics / Q000473:pathology; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities / Q000378:metabolism* / Q000473:pathology; D016896:Treatment Outcome