Arsenic transport in prokaryotes and eukaryotic microbes.
Aquaporins (AQPs) and aquaglyceroporins facilitate transport of a broad spectrum of substrates such as water, glycerol and other small uncharged solutes. More recently, AQPs ave also been shown to facilitate diffusion of metalloids such as arsenic (As) and antimony (Sb). At neutral pH, the trivalent forms of these metalloids are structurally similar to glycerol and hence they can enter cells through AQPs. As- and Sb-containing compounds are toxic to cells, yet both metalloids are used as chemotherapeutic agents for treating acute promyelocytic leukemia and diseases caused by protozoan parasites. In this chapter, we will review the role of AQPs and other proteins in metalloid transport in prokaryotes and eukaryotic microbes.
Rosen
Barry P
BP
Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Tamás
Markus J
MJ
D000818:Animals; D000965:Antimony / Q000737:chemistry; D020346:Aquaporins / Q000378:metabolism*; D001151:Arsenic / Q000737:chemistry / Q000378:metabolism*; D001152:Arsenicals / Q000737:chemistry; D001692:Biological Transport; D002417:Cattle; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry; D008954:Models, Biological; D008958:Models, Molecular; D010272:Parasitic Diseases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D020346:Aquaporins; D001152:Arsenicals; D008670:Metals; D000965:Antimony; D001151:Arsenic