title: The effect of microvascular decompression in patients with multiple sclerosis and trigeminal neuralgia.
abstract: BACKGROUND
  Trigeminal neuralgia (TN) in patients with multiple sclerosis (MS) is thought to be caused by demyelinating plaques within the nerve root entry zone, the trigeminal nucleus, or the trigeminal tracts.
  
  
  OBJECTIVE
  To review our experience of microvascular decompression (MVD) in patients with MS and symptomatic TN.
  
  
  METHODS
  All first-time MVDs for symptomatic trigeminal neuralgia in patients with MS performed by the senior author during an 8-year period (1999-2007) in this department were reviewed. The preoperative pain components were differentiated as being 100% episodic pain, > 50% episodic pain, or > 50% constant pain. At follow-up, pain relief was assessed with a standard mail questionnaire; those still having residual pain were further examined in the outpatient clinic or interviewed by phone.
  
  
  RESULTS
  Of the 19 MS patients, 15 were available for follow-up. The median observation period was 55 months (range, 17-99 months). At follow-up, 7 of 15 patients (47%) were completely free of their episodic pain, and an additional 4 (27%) had significant relief of episodic pain (ie, worst pain marked as 0 to 3 cm on a 10-cm visual analog scale). Among the subgroup of 8 patients with a constant pain component, all were free of their constant pain, and 4 (50%) were free of their episodic pain.
  
  
  CONCLUSIONS
  In our 8-year experience of doing MVD in MS patients with TN, we found complete and significant relief of episodic TN in a large proportion of patients. Even those with a constant pain component before MVD were completely relieved of their constant pain. Thus, in patients with TN (with or without a constant pain component), the presence of MS should not prevent patients from being offered MVD.
authors.affiliation: Department of Neurosurgery, Division of Clinical Neuroscience, Rikshospitalet University Hospital, Oslo, Norway.
authors.forename: Tiril
authors.initials: T
authors.lastname: Sandell
authors.forename: Per Kristian
authors.initials: PK
authors.lastname: Eide
mesh_terms: D000328:Adult; D000368:Aged; D019299:Decompression, Surgical / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D019635:Neurosurgical Procedures / Q000379:methods*; D012189:Retrospective Studies; D014276:Trigeminal Nerve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D014278:Trigeminal Nuclei / Q000473:pathology / Q000503:physiopathology; D014656:Vascular Surgical Procedures / Q000379:methods*