Antiproliferative diterpenoids from the leaves of Isodon rubescens.
A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E ( 1- 5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant.
Gao
Xue-Mei
XM
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Luo
Xiao
X
Pu
Jian-Xin
JX
Wu
Ying-Li
YL
Zhao
Yong
Y
Yang
Li Bin
LB
He
Fei
F
Li
Xiao Nian
XN
Xiao
Wei-Lie
WL
Chen
Guo-Qiang
GQ
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts