Controlling the direction of division.
Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?
Satir
Peter
P
D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics*; D000818:Animals; D002455:Cell Division; D016764:Cell Polarity / Q000235:genetics*; D002923:Cilia / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000166:cytology* / Q000254:growth & development; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology* / Q000254:growth & development; D051379:Mice; D008941:Spindle Apparatus / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics
C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein; D051153:Wnt Proteins