Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection.
OBJECTIVE
Three year post-surgical morbidity levels were compared between patients with negative sentinel lymph node dissection alone (SLND) and those with negative sentinel node dissection and negative axillary lymph node dissection (ALND) in the NSABP B-32 trial.


METHODS
A total of 1,975 ALND and 2,008 SLND node negative breast cancer patients had shoulder range of motion and arm volumes assessed along with self reports of arm tingling and numbness. Relative shoulder abduction deficits and relative arm volume differences between ipsilateral and contralateral arms were calculated.


RESULTS
Shoulder abduction deficits >or=10% peaked at 1 week for the ALND (75%) and SLND (41%) groups. Arm volume differences >or=10% at 36 months were evident for the ALND (14%) and SLND (8%) groups. Numbness and tingling peaked at 6 months for the ALND (49%, 23%) and SLND (15%, 10%) groups. Logistic regression correlates of residual morbidity included treatment group, age, handedness, tumor size, systemic chemotherapy, and radiation to the axilla.


CONCLUSIONS
Although residual morbidity for both treatment groups was evident, the results of the NSABP B-32 study indicate the superiority of the SLND compared to the ALND treatment approach relative to post-surgical morbidity outcomes over a 3-year follow-up period.
Ashikaga
Takamaru
T
University of Vermont College of Medicine, Burlington, Vermont 05405, USA. takamaru.ashikaga@uvm.edu
Krag
David N
DN
Land
Stephanie R
SR
Julian
Thomas B
TB
Anderson
Stewart J
SJ
Brown
Ann M
AM
Skelly
Joan M
JM
Harlow
Seth P
SP
Weaver
Donald L
DL
Mamounas
Eleftherios P
EP
Costantino
Joseph P
JP
Wolmark
Norman
N
D001132:Arm / Q000503:physiopathology; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006987:Hypesthesia / Q000209:etiology / Q000503:physiopathology; D008197:Lymph Node Excision / Q000009:adverse effects / Q000379:methods*; D008209:Lymphedema / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000502:physiology; D021701:Sentinel Lymph Node Biopsy; D012785:Shoulder Joint / Q000503:physiopathology