title: Methicillin-resistant Staphylococcus aureus resistance to non-beta-lactam antimicrobials in the United States from 1996 to 2008.
abstract: We report the resistance rates of Staphylococcus aureus to non-beta-lactam antimicrobials from The Surveillance Network Database-USA (Eurofins-Medinet, Chantilly, VA). Specimens studied were from lower respiratory tract, wounds, and blood. Patients were stratified by age group and patient setting. There were 2,053,219 isolates of S. aureus and 973,116 of methicillin-resistant S. aureus (MRSA). The MRSA rate increased until 2004 and then leveled off. MRSA showed decreasing resistance to tetracycline and trimethoprim-sulfamethoxazole (TMP-SMX). By age group, the greatest MRSA rate increase was for individuals 17 years and younger. Non-beta-lactam antimicrobials and particularly TMP-SMX should be considered therapeutic options for staphylococcal infections.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Providence Hospital, Washington, DC 20017, USA. jbordon@provhosp.org
authors.forename: Jose
authors.initials: J
authors.lastname: Bordon
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Master
authors.forename: Richard B
authors.initials: RB
authors.lastname: Clark
authors.forename: Padmaraj
authors.initials: P
authors.lastname: Duvvuri
authors.forename: James A
authors.initials: JA
authors.lastname: Karlowsky
authors.forename: Kwabena
authors.initials: K
authors.lastname: Ayesu
authors.forename: Alena
authors.initials: A
authors.lastname: Klotchko
authors.forename: Rama
authors.initials: R
authors.lastname: Kapoor
authors.forename: Julio
authors.initials: J
authors.lastname: Ramirez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D001996:Bronchopneumonia / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008875:Middle Aged; D015995:Prevalence; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus; D014481:United States; D014946:Wound Infection / Q000382:microbiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents