No taste for methyl: methylation sensitive proteolysis in drug screening.
Methyltransferases and demethylases are emerging targets for epigenetic therapy. Wigle et al. (2010) present a new assay for the enzyme inhibition of methyltransferases and demethylases based on selective enzymatic cleavage of unmethylated versus methylated peptides and their subsequent electrophoretic separation.
Bissinger
Elisabeth-Maria
EM
Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Jung
Manfred
M