Mortality reduction with beta-blockers in ischemic cardiomyopathy patients undergoing coronary artery bypass grafting.
Coronary artery bypass grafting (CABG) in patients with systolic heart failure (HF) carries high morbidity and mortality rates. Reducing perioperative mortality with beta-blockers (BBs) may help improve outcomes. Analysis of 4903 patients who underwent isolated CABG surgery was performed. In-hospital mortality of systolic HF patients who received BBs was 2.03%; systolic HF patients who did not receive BBs had a mortality of 5.20%. Thirty-day mortality was 2.98% in the patients with systolic HF who received BBs and 6.16% in the patients who did not. beta-Blockade did not affect the mortality in patients with preserved systolic function. Cardiogenic shock was a predictor of increased mortality in patients with systolic HF, while BBs reduced mortality. BBs are associated with decreased in-hospital and 30-day mortality in patients with systolic HF. BB therapy should be considered in patients with systolic HF who are undergoing CABG.
Lin
Terence
T
Stanford University Medical Center, Palo Alto, CA, USA.
Hasaniya
Nahidh W
NW
Krider
Susan
S
Razzouk
Anees
A
Wang
Nan
N
Chiong
Jun R
JR
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality*; D005260:Female; D054143:Heart Failure, Systolic / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012042:Registries; D040242:Risk Reduction Behavior; D012770:Shock, Cardiogenic
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents