title: [Heart rate variability, adrenomedullin and B-type natriuretic peptide before and after transcatheter closure in children with patent ductus arteriosus].
abstract: OBJECTIVE
  To observe the changes of heart rate variability (HRV), adrenomedullin (ADM) and B-type natriuretic peptide (BNP) before and after transcatheter closure in children with patent ductus arteriosus.
  
  
  METHODS
  HRV spectral values (TF, VLF, LF, HF, LF/HF) were detected by 24 dynamic electrocardiogram and the concentrations of plasma ADM and BNP were measured in 55 children with patent ductus arteriosus (Group PDA, n = 55) before and 3(rd) day, 3(rd) month after transcatheter closure therapy, and in 60 normal children (Group C).
  
  
  RESULTS
  (1) Compared with Group C, the HRV spectral values (TF, VLF, HF) were significantly lower (all P < 0.01), LF/HF and the concentrations of plasma ADM, BNP were significantly higher in patients with PDA before transcatheter closure (all P < 0.01). (2) Compared with the values before transcatheter closure values, plasma ADM were significantly reduced at 3(rd) day and 3(rd) month after transcatheter closure (P < 0.01), the HRV spectral values (TF, VLF, HF) were significantly increased while LF/HF and plasma BNP were significantly decreased at 3(rd) month after transcatheter closure (P < 0.01 or P < 0.05).
  
  
  CONCLUSIONS
  HRV and plasma ADM, BNP improved significantly post transcatheter closure in children with patent ductus arteriosus.
authors.affiliation: Department of Pediatric Cardiovascular, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Rong-zhou
authors.initials: RZ
authors.lastname: Wu
authors.forename: Xing
authors.initials: X
authors.lastname: Rong
authors.forename: Yue
authors.initials: Y
authors.lastname: Ren
authors.forename: Xu-xiang
authors.initials: XX
authors.lastname: He
authors.forename: Ru-lian
authors.initials: RL
authors.lastname: Xiang
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin / Q000097:blood*; D006328:Cardiac Catheterization; D002648:Child; D004374:Ductus Arteriosus, Patent / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D055815:Young Adult
chemical_list: D020097:Natriuretic Peptide, Brain; D053607:Adrenomedullin