title: Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome.
abstract: In infertile women suffering from polycystic ovary syndrome (PCOS), anti-thyroid peroxidase antibodies values exceeding the upper level of normal were found in significantly more clomiphene citrate resistant patients compared clomiphene citrate responders and metformin responders. Thus, elevated antiTPO levels are associated with poor treatment response in infertile women who suffer from PCOS.
authors.affiliation: Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Ott
authors.forename: Stefanie
authors.initials: S
authors.lastname: Aust
authors.forename: Christine
authors.initials: C
authors.lastname: Kurz
authors.forename: Kazem
authors.initials: K
authors.lastname: Nouri
authors.forename: Stefan
authors.initials: S
authors.lastname: Wirth
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Huber
authors.forename: Klaus
authors.initials: K
authors.lastname: Mayerhofer
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D054316:Biomarkers, Pharmacological / Q000097:blood; D002996:Clomiphene / Q000627:therapeutic use*; D004351:Drug Resistance / Q000276:immunology; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro / Q000379:methods; D050031:Hashimoto Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000276:immunology; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D054316:Biomarkers, Pharmacological; D005300:Fertility Agents, Female; D033862:Iron-Binding Proteins; D002996:Clomiphene; C056658:TPO protein, human; D007453:Iodide Peroxidase