[Analysis of relation between types of bony metastasis and PSA and tumor differentiation of prostate cancer].
OBJECTIVE
To analyze the relationship between radiological characteristics of bony metastasis and PSA, Gleason score (GS) for prostate cancer patients.


METHODS
The investigators collected the clinical data of 44 patients with prostate cancer bony metastasis and divided them into 3 groups based upon the radiological characteristics of bony metastasis. The 3 groups were osteoblast group, osteoclast group and mixed group.


RESULTS
The mean age of patients was 70 years old. There were 33 cases (75.00%), 9 cases (20.45%) and 2 cases (4.55%) in osteoblast group, osteoclast group and mixed group respectively. The mean total serum PSA values were 590.3+/-177.0 microg/L, 249.0+/-66.6 microg/L and 156.5+/-42.1 microg/L in osteoblast group, osteoclast group and mixed group respectively. No statistic significance was found for the difference of total PSA in 3 groups. Mean GS in osteoblast group was 7.4 (6-10). Twenty-two cases (66.7%) were of a medium-high differentiation (GS<or=7) while 11 cases (33.3%) of a low differentiation (GS>7). Mean GS in osteoclast group was 8.0 (6-10). Among which, 3 cases (33.3%) were of a medium-high differentiation while 6 cases (66.7%) of a low differentiation. Statistic significance was found for the difference of GS in 2 groups. Two cases in mixed group were assigned 8 of GS.


CONCLUSIONS
There is no confirmed correlation between types of bony metastasis and total serum PSA for prostate cancer patients. But the tumor differentiation reflected by Gleason score may affect the type of bony metastasis.
Wang
Jian-wei
JW
Department of Urology, Beijing Jishuitan Hospital, Beijing 100035, China.
Man
Li-bo
LB
Huang
Guang-lin
GL
Li
Gui-zhong
GZ
He
Feng
F
Wang
Hai-dong
HD
Wang
Hai
H
Liu
Ning
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*
D017430:Prostate-Specific Antigen