title: An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy.
abstract: The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases.
authors.affiliation: Small Animal Surgery Section, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pivate Bag X04, Onderstepoort, 0110 South Africa. bruce@ovation.co.za
authors.forename: B
authors.initials: B
authors.lastname: Nevill
authors.forename: A
authors.initials: A
authors.lastname: Leisewitz
authors.forename: A
authors.initials: A
authors.lastname: Goddard
authors.forename: P
authors.initials: P
authors.lastname: Thompson
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism*; D004285:Dogs / Q000097:blood* / Q000601:surgery*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D007796:Laminectomy / Q000662:veterinary; D008297:Male; D010052:Ovariectomy / Q000662:veterinary; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein; D003402:Creatine Kinase