title: Histologic analysis of healing after tooth extraction with ridge preservation using mineralized human bone allograft.
abstract: BACKGROUND
  Ridge preservation was developed as a therapy to prevent severe bone resorption after tooth extraction. The purpose of this study is to determine if there is any difference in the amount of new bone formation ≈3 months after extraction and ridge preservation compared to that after ≈6 months.
  
  
  METHODS
  Minimally traumatic extraction with ridge preservation using mineralized human bone allograft was performed at 38 single-rooted tooth sites in 33 subjects. Sixteen sites healed for an average of 14 weeks (early healing), whereas 22 sites were allowed to heal for an average of 27 weeks (delayed healing) before harvesting bone core samples. Histomorphometric analysis was performed to determine the percent of new bone formation, residual graft particles, and connective tissue/non-mineralized structures for each site.
  
  
  RESULTS
  All specimens showed evidence of new bone formation, with most of the residual graft particles surrounded intimately by woven bone. No statistically significant differences in the amount of newly formed bone or residual graft particles were found between the two groups. Overall, the early healing group demonstrated a mean of 45.8% new bone, 14.6% residual graft material, and 39.6% connective tissue/non-mineralized tissue. The delayed healing group showed mean values of 45%, 13.5%, and 41.3%, respectively.
  
  
  CONCLUSIONS
  The results of this study suggest that waiting ≈6 months after tooth extraction and ridge preservation using mineralized bone allograft does not provide a greater amount of new bone formation or less residual bone particles compared to that after only ≈3 months.
authors.affiliation: Department of Periodontics, University of Texas Health Science Center San Antonio, San Antonio, TX 78229–3900, USA.
authors.forename: Tina M
authors.initials: TM
authors.lastname: Beck
authors.forename: Brian L
authors.initials: BL
authors.lastname: Mealey
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000539:Alveolar Process / Q000473:pathology*; D016025:Bone Transplantation / Q000379:methods*; D002113:Calcification, Physiologic / Q000502:physiology; D003094:Collagen; D054893:Cone-Beam Computed Tomography; D003238:Connective Tissue / Q000473:pathology; D003758:Dental Implantation, Endosseous; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D010027:Osteotomy; D019237:Tooth Cervix / Q000473:pathology; D014081:Tooth Extraction / Q000379:methods*; D020390:Tooth Socket / Q000473:pathology; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000502:physiology
chemical_list: D008567:Membranes, Artificial; D003094:Collagen