[Expressions of CD147, MMP-2 and MMP-9 in laryngeal carcinoma and clinical significance].
OBJECTIVE
To investigate the expressions of extracellular matrix metalloproteinase inducer (CD147), matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9) in human laryngeal carcinoma and study their relationship with invasion, metastasis and prognosis.


METHODS
The EnVision immunohistochemical method was used to detect the expressions of CD147, MMP-2 and MMP-9 in 48 cases of laryngeal carcinoma and 15 cases of laryngitis. The results were compared with their clinical pathological features and prognosis.


RESULTS
The positive expression rates of CD147, MMP-2 and MMP-9 were significantly higher in laryngeal carcinoma than those in laryngitis (87.5%, 75.0%, 79.2% vs 26.7%, 6.7%, 33.3%); there was a positive correlation between a high-level expression of CD147, MMP-2, MMP-9 and clinical stage and the status of lymph node metastasis (P < 0.01); univariate analysis indicated that the overall survival rate was higher in patients with a negative expression of CD147, MMP-2, MMP-9 than those with a positive expression (83.3%, 83.3%, 90.0% vs 25.0%, 7.7%, 18.2%); multivariate analysis showed that MMP-9 was a risk predictor. A higher expression of MMP-9 was associated with a shorter survival time.


CONCLUSIONS
CD147 and MMP-2 play a role in invasion and metastasis of laryngeal carcinoma; increased levels of MMP-2 and MMP-9 are induced by CD147 in laryngeal tumor cells; MMP-9 may be an independent prognostic factor.
Gou
Xiao-xia
XX
Department of Head and Neck Oncology, Guizhou Cancer Hospital, Guiyang 550003, China.
Jin
Feng
F
Chen
Hai-xia
HX
Wu
Wei-li
WL
Chen
Lu
L
Zeng
Ying
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051926:Basigin / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
D051926:Basigin; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9