title: Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia.
abstract: Painting in the home has been identified as a potential risk factor for childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether exposure to house painting or floor treatments before birth or during childhood increased the risk of childhood ALL. Data from 389 cases and 876 frequency-matched controls were analyzed using unconditional logistic regression, adjusting for study matching variables and potential confounders. Overall, there was little evidence of an increased risk with painting inside the house in the year before the pregnancy, during the pregnancy, or after the child's birth; however, the risk appeared to be increased in certain circumstances. The odds ratio (OR) for more than three rooms being painted during pregnancy was 1.68 [95% confidence interval (CI) 1.01, 2.80]. The OR for someone other than the parents painting inside the house in the year before the pregnancy was 2.37 (95% CI 1.30, 4.30) and 3.07 (95% CI 1.46, 6.46) when more than three rooms were painted. The OR for the mother painting the outside of the house with oil-based paint in the year before the pregnancy was 2.97 (95% CI 1.06, 8.33). No association was found with having floor treatments in any time period. We found some evidence of an increased risk of ALL associated with house painting. An apparently increased risk associated with someone other than the parents painting inside the house may be related to the amount of paint used and the intensity of the dose received.
authors.affiliation: Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, WA, Australia. helenb@ichr.uwa.edu.au
authors.forename: Helen D
authors.initials: HD
authors.lastname: Bailey
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Milne
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: de Klerk
authors.forename: Lin
authors.initials: L
authors.lastname: Fritschi
authors.forename: John
authors.initials: J
authors.lastname: Attia
authors.forename: Catherine
authors.initials: C
authors.lastname: Cole
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Armstrong
mesh_terms: D000293:Adolescent; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D005260:Female; D005430:Floors and Floorcoverings; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D010150:Paint / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D012307:Risk Factors