[Differences between the CKD-EPI and the MDRD equations when estimating the glomerular filtration rate in hypertensive patients].
OBJECTIVE
To analyze the agreement in glomerular filtration rate (GFR) estimated with CKD-EPI and MDRD-IDMS equations in a cohort of hypertensive patients.


METHODS
We included consecutively 478 hypertensive patients, mean age 57.58 yr (SD: 12.34), 68.3% males. The estimation of GFR was performed with MDRD-IDMS and CKD-EPI equations and we analyzed the agreement between them.


RESULTS
The estimation of GFR with CKD-EPI was 4.37 (95%:3.73-4.19) mL/min/1,73 m2 higher than MDRD-IDMS, overall and by gender (males 3.99; females 5.04). In patients under 65 years the difference was greater, 6.55 (95%:5.95-7.15) mL/min/1.73 m2 in both men 6.07 and women 6.48. However, we found no significant difference over 65 years. Intraclass correlation coefficient was 0.904 (95% CI:0.886-0.919), 0.897 men and 0.917 women and Kappa index 0.848 (95% CI :0.795-0.889), 0.845 men and 0.852 women.


CONCLUSIONS
CKD-EPI equation estimated a higher GFR in hypertensive patients under 65 years and reclassified in stage 1 patients classified in stage 2 by MDRD-IDMS.
Gómez Marcos
M A
MA
Atención Primaria, Unidad de Investigación La Alamedilla, Salamanca. magomez@usal.es
Rodríguez Sánchez
E
E
Recio Rodríguez
J I
JI
Martín Cantera
M
M
Ramos Blanes
R
R
García Ortiz
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007677:Kidney Function Tests / Q000706:statistics & numerical data; D008297:Male; D008433:Mathematics; D008875:Middle Aged