title: Combination of boundary element method and finite element method in diffuse optical tomography.
abstract: This paper presents a new numerical method for optical tomography: the combined boundary element/finite element method (BEM-FEM), designed to tackle reconstructions in layered turbid media. The BEM-FEM focuses on the region of interest by creating a volume mesh and reconstructing in this region only. All other regions are treated as piecewise-constant in a surface-integral approach. We validate the model in concentric spheres, with different positions of the volume-integral treated area and found it compared well with an analytical result. We then performed functional imaging of the neonates motor cortex in vivo, in a reconstruction restricted to the brain, both with FEM and BEM-FEM. These results show the effectiveness of the BEMFEM in situations where the organ of interest is surrounded by superficial layers.
authors.forename: Josias Pierrick
authors.initials: JP
authors.lastname: Elisee
authors.forename: Adam
authors.initials: A
authors.lastname: Gibson
authors.forename: Simon
authors.initials: S
authors.lastname: Arridge
mesh_terms: D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D008954:Models, Biological; D009044:Motor Cortex / Q000502:physiology; D015203:Reproducibility of Results; D041622:Tomography, Optical / Q000379:methods*