title: Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats.
abstract: Tulathromycin is a triamilide antibiotic that maintains therapeutic concentrations for an extended period of time. The drug is approved for the treatment of respiratory disease in cattle and swine and is occasionally used in goats. To investigate the pharmacokinetics of tulathromycin in meat goats, 10 healthy Boer goats were administered a single 2.5 mg/kg subcutaneous dose of tulathromycin. Plasma concentrations were measured by ultra-high pressure liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detection. Plasma maximal drug concentration (Cmax) was 633 ± 300 ng/ml (0.40 ± 0.26 h post-subcutaneous injection). The half-life of tulathromycin in goats was 110 ± 19.9 h. Tulathromycin was rapidly absorbed and distributed widely after subcutaneous injection 33 ± 6 L/kg. The mean AUC of the group was 12,500 ± 2020 h ng/mL for plasma. In this study, it was determined that the pharmacokinetics of tulathromycin after a single 2.5 mg/kg SC injection in goats were very similar to what has been previously reported in cattle.
authors.affiliation: Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Young
authors.forename: Geof W
authors.initials: GW
authors.lastname: Smith
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Leavens
authors.forename: Scott E
authors.initials: SE
authors.lastname: Wetzlich
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Baynes
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Mason
authors.forename: Jim E
authors.initials: JE
authors.lastname: Riviere
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Tell
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004187:Disaccharides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006041:Goats / Q000097:blood / Q000378:metabolism; D006207:Half-Life; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007279:Injections, Subcutaneous / Q000662:veterinary; D053719:Tandem Mass Spectrometry / Q000662:veterinary; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides