title: Intestinal-FABP and liver-FABP: Novel markers for severe abdominal injury.
abstract: OBJECTIVE
  Fatty acid-binding proteins (FABPs) have relatively high tissue concentrations and low plasma concentrations and are released into the circulation following organ injury. We explored the utility of intestinal-(I)-FABP and liver-(L)-FABP for the diagnosis of abdominal injury in patients with multiple trauma.
  
  
  METHODS
  This prospective study included 102 trauma patients and 30 healthy volunteers. Plasma I-FABP and L-FABP levels were measured in the emergency department (ED) by enzyme-linked immunosorbent assay (ELISA). Forty-one patients suffered from serious or severe abdominal trauma (Abbreviated Injury Score [AIS] code "ai" for abdominal injury, AISai > or = 3) and nine were moderately abdominally injured (AISai < 3). Fifty-two had no abdominal injury.
  
  
  RESULTS
  Median I-FABP and L-FABP levels in the AISai > or = 3 group (516 pg/mL and 135 ng/mL, respectively) were significantly higher compared to the AISai < 3 group (154 pg/mL and 13 ng/mL, respectively) or those without abdominal injury (207 pg/mL and 21 ng/mL, respectively) or normal controls (108 pg/mL and 13 ng/mL, respectively). The cutoff to distinguish the ai > or = 3 is 359 pg/mL for I-FABP and 54 ng/mL for L-FABP, with 93% specificity and 75% sensitivity for I-FABP and 93% and 82% for L-FABP, respectively.
  
  
  CONCLUSIONS
  High I-FABP and L-FABP levels correlate with relevant severity of abdominal tissue damage in patients with multiple trauma. I-FABP and L-FABP could be useful as markers for the early detection of significant abdominal injury in acute multiple trauma and identify patients who require rapid intervention.
authors.affiliation: Department of Trauma Surgery, Johann Wolfgang Goethe University Frankfurt am Main, Germany. info@bornarelja.com
authors.forename: Borna
authors.initials: B
authors.lastname: Relja
authors.forename: Maika
authors.initials: M
authors.lastname: Szermutzky
authors.forename: Dirk
authors.initials: D
authors.lastname: Henrich
authors.forename: Marcus
authors.initials: M
authors.lastname: Maier
authors.forename: Jacco-Juri
authors.initials: JJ
authors.lastname: de Haan
authors.forename: Tim
authors.initials: T
authors.lastname: Lubbers
authors.forename: Wim A
authors.initials: WA
authors.lastname: Buurman
authors.forename: Ingo
authors.initials: I
authors.lastname: Marzi
mesh_terms: D000007:Abdominal Injuries / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins