[Improvement of left ventricular function during combined carvedilol, ramipril and spironolactone therapy after myocarditis in patient treated earlier by chemotherapy due to Hodgkin's lymphoma - 3-years follow-up].
The case of woman with dysfunction of left ventricle (LV) possible due to Hodgkin's lymphoma treatment and following myocarditis is presented. Triple therapy with carvedilol, ramipril and spironolactone was continued to prevent further LV remodeling. During 3-years follow-up repeated echocardiographic examinations revealed gradual improvement of LV function and clinical condition of the patient. Results of current studies suggest benefits of early implementation of aldosterone antagonist therapy in addition to ACE-inhibitors/angiotensin receptors blockers and beta-blockers in patients with chronic heart failure.
Dabrowski
Rafał
R
Instytut Kardiologii, Warszawa.
Pedzich-Placha
Ewa
E
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D002227:Carbazoles / Q000008:administration & dosage*; D000077261:Carvedilol; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage; D009205:Myocarditis / Q000188:drug therapy* / Q000209:etiology; D011412:Propanolamines / Q000008:administration & dosage*; D017257:Ramipril / Q000008:administration & dosage*; D013148:Spironolactone / Q000008:administration & dosage*; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy* / Q000209:etiology; D016277:Ventricular Function, Left / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002227:Carbazoles; D000451:Mineralocorticoid Receptor Antagonists; D011412:Propanolamines; D000077261:Carvedilol; D013148:Spironolactone; D017257:Ramipril