Fabrication of micropatterns of nanoarrays on a polymeric gel surface.
Micro-nano patterns of gold on the surface of poly(ethylene glycol) (PEG) hydrogels were prepared. The approach combines the technique of conventional photolithography (a top-down method for micropatterns), block copolymer micelle nanolithography (a bottom-up method for gold nanopatterns), and a linker-assistant technique to transfer a pattern on a hard surface to a polymeric surface. Hybrid micro-nano patterns on hydrogels were characterized using scanning electron microscopy, atomic force microscopy and X-ray photoelectron spectroscopy. The patterned Au nanoparticles were further modified by a peptide containing arginine-glycine-aspatate (RGD). The cell-adhesion contrast of the patterned hydrogel surface was confirmed by preliminary cell experiments.
Liu
Peng
P
Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai, China.
Sun
Jianguo
J
Huang
Jinghuan
J
Peng
Rong
R
Tang
Jian
J
Ding
Jiandong
J
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D006046:Gold / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D018625:Microscopy, Atomic Force; D009842:Oligopeptides / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
D020100:Hydrogels; D009842:Oligopeptides; D011108:Polymers; D011092:Polyethylene Glycols; D006046:Gold; C047981:arginyl-glycyl-aspartic acid