title: Encapsulation of dual cytotoxic and anti-angiogenic gold(III) complexes by gelatin-acacia microcapsules: in vitro and in vivo studies.
abstract: Encapsulation of the anticancer gold(III) complexes bearing porphyrin or Schiff-base ligands by gelatin-acacia microcapsules confers both sustained-release and rapid-release properties, improved solution stability and/or in vivo efficacy compared to that using the unencapsulated complexes alone.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Jessie Jing
authors.initials: JJ
authors.lastname: Yan
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Marie C M
authors.initials: MC
authors.lastname: Lin
authors.forename: Albert S-C
authors.initials: AS
authors.lastname: Chan
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000045:Acacia; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002214:Capsules; D045744:Cell Line, Tumor; D004339:Drug Compounding; D004354:Drug Screening Assays, Antitumor; D005780:Gelatin; D006801:Humans; D008665:Metalloporphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D010316:Particle Size
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D002214:Capsules; D008665:Metalloporphyrins; C508665:gold (III) porphyrin 1a; D005780:Gelatin