Cell migration: MIM takes the driver's seat.
A recent study reports a novel and conserved function for the I-BAR protein MIM in guiding cell migration: MIM has an anti-endocytic activity that moderates intracellular signalling of guidance cues by sequestration of cortactin.
Van de Bor
Véronique
V
Institute of Developmental Biology & Cancer UMR6543/CNRS, University of Nice Sophia-Antipolis, Parc Valrose, 06108 Nice cedex 2, France.
Noselli
Stéphane
S
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D051356:Cortactin / Q000378:metabolism; D004330:Drosophila / Q000196:embryology* / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
D051356:Cortactin; D029721:Drosophila Proteins; C549400:MIM protein, Drosophila; D008840:Microfilament Proteins