title: Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist.
authors.affiliation: Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan, ROC.
authors.forename: Ming-Shiu
authors.initials: MS
authors.lastname: Hung
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Chang
authors.forename: Ting-Chieh
authors.initials: TC
authors.lastname: Li
authors.forename: Teng-Kuang
authors.initials: TK
authors.lastname: Yeh
authors.forename: Jen-Shin
authors.initials: JS
authors.lastname: Song
authors.forename: Yinchiu
authors.initials: Y
authors.lastname: Lin
authors.forename: Chien-Huang
authors.initials: CH
authors.lastname: Wu
authors.forename: Po-Chu
authors.initials: PC
authors.lastname: Kuo
authors.forename: Prashanth K
authors.initials: PK
authors.lastname: Amancha
authors.forename: Ying-Chieh
authors.initials: YC
authors.lastname: Wong
authors.forename: Wen-Chi
authors.initials: WC
authors.lastname: Hsiao
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Chao
authors.forename: Kak-Shan
authors.initials: KS
authors.lastname: Shia
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry* / Q000494:pharmacology; D001812:Blood-Brain Barrier / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D054314:Drug Inverse Agonism; D006801:Humans; D007035:Hypothermia / Q000188:drug therapy; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: C554616:1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide; D019440:Anti-Obesity Agents; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; D013876:Thiophenes