title: Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission.
abstract: To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particularly the details of 641 patients transplanted in CR1. Overall survival was significantly superior among patients transplanted in CR1, but no significant difference was observed between related and unrelated allo-SCTs (related vs unrelated: 65% vs 62% at 4 years, respectively; P = .19). Among patients transplanted in CR1, relapse rates were significantly higher in related allo-SCT compared with unrelated allo-SCT, and multivariate analysis demonstrated that less than 6 months from diagnosis to allo-SCT alone was associated with relapse. On the other hand, nonrelapse mortality (NRM) was significantly higher in unrelated allo-SCT compared with related allo-SCT, and multivariate analysis demonstrated that 10 months or longer from diagnosis to allo-SCT, human leukocyte antigen mismatch, and abnormal karyotype were associated with NRM. In conclusion, our study showed comparable survival rates but different relapse rates, NRM rates, and risk factors between related and unrelated allo-SCTs. After a close consideration of these factors, the outcome of allo-SCT for adult Ph(-) ALL in CR1 could be improved.
authors.affiliation: Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan. n-3104@tf7.so-net.ne.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishiwaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inamoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.forename: Mineo
authors.initials: M
authors.lastname: Kurokawa
authors.forename: Hiroatsu
authors.initials: H
authors.lastname: Iida
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuda
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kasai
authors.forename: Takehiko
authors.initials: T
authors.lastname: Mori
authors.forename: Koji
authors.initials: K
authors.lastname: Iwato
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Makoto
authors.initials: M
authors.lastname: Onizuka
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishima
authors.forename: Ritsuro
authors.initials: R
authors.lastname: Suzuki
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Atsuta
authors.forename: Koichi
authors.initials: K
authors.lastname: Miyamura
mesh_terms: D000293:Adolescent; D000328:Adult; D002423:Cause of Death; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality* / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction; D012307:Risk Factors; D033581:Stem Cell Transplantation; D015996:Survival Rate; D014019:Tissue Donors; D014184:Transplantation, Homologous; D055815:Young Adult