title: Is a gene-centric human proteome project the best way for proteomics to serve biology?
abstract: With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In "proteomics speak", the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far.
authors.affiliation: Biochemistry and Biophysics of Integrated Systems, UMR CNRS-CEA-UJF 5092, CEA Grenoble, iRTSV/BSBBSI, Grenoble, France. Thierry.Rabilloud@cea.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Rabilloud
authors.forename: Denis
authors.initials: D
authors.lastname: Hochstrasser
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Simpson
mesh_terms: D023281:Genomics; D006801:Humans; D020543:Proteome / Q000235:genetics*; D040901:Proteomics; D049490:Systems Biology
chemical_list: D020543:Proteome