title: Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis.
abstract: BACKGROUND
  Several studies demonstrated an association of homocysteine plasma levels and the plasma lipoprotein profile. This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile.
  
  
  METHODS
  In a retrospective single center approach, we analyzed the laboratory database (2003-2006) of the University Hospital Bonn, Germany, including 1743 individuals, in whom vitamin B12, folate and at least one lipoprotein parameter had been determined by linear multilogistic regression.
  
  
  RESULTS
  Higher folate serum levels were associated with lower serum levels of low density lipoprotein cholesterol (LDL-C; Beta = -0.164; p < 0.001), higher levels of high density lipoprotein cholesterol (HDL-C; Beta = 0.094; p = 0.021 for trend) and a lower LDL-C-C/HDL-C-ratio (Beta = -0.210; p < 0.001). Using ANOVA, we additionally compared the individuals of the highest with those of the lowest quartile of folate. Individuals of the highest folate quartile had higher levels of HDL-C (1.42 +/- 0.44 mmol/l vs. 1.26 +/- 0.47 mmol/l; p = 0.005), lower levels of LDL-C (3.21 +/- 1.04 mmol/l vs. 3.67 +/- 1.10 mmol/l; p = 0.001) and a lower LDL-C/HDL-C- ratio (2.47 +/- 1.18 vs. 3.77 +/- 5.29; p = 0.002). Vitamin B12 was not associated with the lipoprotein profile.
  
  
  CONCLUSIONS
  In our study sample, high folate levels were associated with a favorable lipoprotein profile. A reconfirmation of these results in a different study population with a well defined status of health, diet and medication is warranted.
authors.affiliation: University Zurich, Department of Neurology, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Semmler
authors.forename: Susanna
authors.initials: S
authors.lastname: Moskau
authors.forename: Andreas
authors.initials: A
authors.lastname: Grigull
authors.forename: Susan
authors.initials: S
authors.lastname: Farmand
authors.forename: Thomas
authors.initials: T
authors.lastname: Klockgether
authors.forename: Yvo
authors.initials: Y
authors.lastname: Smulders
authors.forename: Henk
authors.initials: H
authors.lastname: Blom
authors.forename: Bernd
authors.initials: B
authors.lastname: Zur
authors.forename: Birgit
authors.initials: B
authors.lastname: Stoffel-Wagner
authors.forename: Michael
authors.initials: M
authors.lastname: Linnebank
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D012189:Retrospective Studies; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D005492:Folic Acid; D014805:Vitamin B 12