title: Racial differences in the association between sex hormone-binding globulin and adiposity in premenopausal women: the BioCycle study.
abstract: OBJECTIVE
  To assess the associations between measures of adiposity and sex hormone- binding globulin (SHBG) and to evaluate whether such associations differ by race.
  
  
  METHODS
  Adiposity was measured by anthropometry and dual-energy X-ray absorptiometry among women (146 white, 50 black, and 25 Asian) aged 18-44 years in the BioCycle study. SHBG was repeatedly measured over one to two menstrual cycles. The ratio of trunkal to leg fat (T/L) was used to assess upper to lower body adiposity.
  
  
  RESULTS
  Among whites, all adiposity measures were significantly and inversely associated with SHBG. Among blacks, BMI (β = -0.032), waist circumference (β = -0.016), and T/L (β = -0.033) were significantly associated with SHBG, whereas total and trunkal fat were not (P interaction with race <0.04). Among Asians, measures of central and upper body fat were significantly associated with SHBG (e.g., T/L, β = -0.84) but not BMI.
  
  
  CONCLUSIONS
  Associations between SHBG and adiposity differ by race among premenopausal women.
authors.affiliation: Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Edwina H
authors.initials: EH
authors.lastname: Yeung
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.forename: Mary L
authors.initials: ML
authors.lastname: Hediger
authors.forename: Jean
authors.initials: J
authors.lastname: Wactawski-Wende
authors.forename: Enrique F
authors.initials: EF
authors.lastname: Schisterman
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000208:ethnology* / Q000502:physiology*; D000328:Adult; D044383:Black People; D015992:Body Mass Index; D005260:Female; D006801:Humans; D017697:Premenopause / Q000208:ethnology* / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D044465:White People; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin