Chronic meningococcaemia and immunoglobulin A deficiency.
Chronic meningococcaemia is an unusual clinical presentation of Neisseria meningitidis infection. We describe the case of a patient, who presented with total IgA deficiency and partial IgM deficiency with a low switched memory B cells count, suggestive of a borderline form of common variable immunodeficiency (CVID). The role of IgA in the protection against Neisseria meningitidis, and the link between IgA deficiency and CVID are discussed.
Theulin
Arnaud
A
Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
Rondeau-Lutz
Murielle
M
Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
Kuhnert
Cornelia
C
Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
Boileau
Julien
J
Clinical Immunology Department, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
Weber
Jean-Christophe
JC
Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis*; D005076:Exanthema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008589:Meningococcal Infections / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology; D009345:Neisseria meningitidis / Q000302:isolation & purification*; D055815:Young Adult
D007070:Immunoglobulin A