title: Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients.
abstract: Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear analysis methods can complement the traditional description of neuronal firing characteristics. Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS). The activity of 8 neurons was recorded prior to, during, and following systemic administration of the dopamine agonist apomorphine at clinically effective doses. Apomorphine induced a decrease in entropy measured in the inter-spike intervals of sub-thalamic neurons in 6 of the 8 neurons. This is the first report that anti-parkinsonian drugs affect non-linear features of neuronal firing in the basal ganglia of parkinsonian patients.
authors.affiliation: Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. myriam.lafreniere.roula@utoronto.ca
authors.forename: M
authors.initials: M
authors.lastname: Lafreniere-Roula
authors.forename: O
authors.initials: O
authors.lastname: Darbin
authors.forename: W D
authors.initials: WD
authors.lastname: Hutchison
authors.forename: T
authors.initials: T
authors.lastname: Wichmann
authors.forename: A M
authors.initials: AM
authors.lastname: Lozano
authors.forename: J O
authors.initials: JO
authors.lastname: Dostrovsky
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D001058:Apomorphine / Q000627:therapeutic use*; D046690:Deep Brain Stimulation; D019277:Entropy; D006801:Humans; D009474:Neurons / Q000187:drug effects*; D010300:Parkinson Disease / Q000188:drug therapy*; D020531:Subthalamic Nucleus / Q000187:drug effects*
chemical_list: D001058:Apomorphine