Development of resin adsorbents for blood purification at Nankai University in China.
Various types of porous resin adsorbents based on polystyrene, agarose, and cellulose as matrixes coupling with DNA, amino acids and other biological active molecules as ligands were extensively studied in China. Molecular recognition between the ligand and pathogenic molecule was investigated. Several commercialized products are now widely used in hospitals all over China. Whole blood hemoperfusion is used to treat patients suffering from autoimmune diseases, uremia acute intoxication, and hyperbilirubinemia. Clinical performances of hundreds and thousands of patients treated by whole blood sorption therapy show that the therapy is safe, efficient, and cost-effective.
Wang
Yong-Jian
YJ
Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin, China.
Yu
Yao-Ting
YT
D000327:Adsorption; D001666:Binding Sites, Antibody / Q000276:immunology; D002482:Cellulose / Q000138:chemical synthesis / Q000737:chemistry; D002681:China; D003362:Cost-Benefit Analysis; D004247:DNA / Q000276:immunology; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007164:Immunosorbents; D010951:Plasma Exchange / Q000379:methods*; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis / Q000737:chemistry; D011137:Polystyrenes / Q000138:chemical synthesis / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000138:chemical synthesis / Q000737:chemistry; D012117:Resins, Synthetic / Q000138:chemical synthesis* / Q000737:chemistry*; D012685:Sepharose / Q000138:chemical synthesis / Q000737:chemistry; D016060:Sorption Detoxification / Q000379:methods*
D007164:Immunosorbents; D011137:Polystyrenes; D012117:Resins, Synthetic; D011142:Polyvinyl Alcohol; D002482:Cellulose; D004247:DNA; D019904:Polymethyl Methacrylate; D012685:Sepharose