UV-induced TA photoproducts: formation and hydrolysis in double-stranded DNA.
Hydrolysis of TA photoproduct leads to two derivatives presenting different formation kinetic profiles depending on the oligomer content. The formation efficiency of TA photoproducts in UV-C-irradiated DNA slightly exceeds the formation of the trans,syn cyclobutane pyrimidine dimer at TT sites.
Asgatay
Saâdia
S
Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, UFR de Pharmacie, Université de Reims Champagne Ardenne, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France.
Martinez
Agathe
A
Coantic-Castex
Stéphanie
S
Harakat
Dominique
D
Philippe
Coralie
C
Douki
Thierry
T
Clivio
Pascale
P
D004247:DNA / Q000737:chemistry*; D006868:Hydrolysis; D055668:Photochemical Processes; D011740:Pyrimidine Dimers / Q000737:chemistry*; D014466:Ultraviolet Rays
D011740:Pyrimidine Dimers; D004247:DNA