Enantioselective nickel-catalyzed reductive coupling of alkynes and imines.
The nickel-catalyzed reductive coupling of alkynes and imines with Et(2)Zn as a reductant by using electron-rich phosphine ligands has been developed, affording various allylic amines with high yields and excellent chemoselectivities. Chiral induction was also achieved in this reductive coupling reaction when a nickel catalyst containing a chiral spiro phosphine ligand was used.
Zhou
Chang-Yue
CY
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Zhu
Shou-Fei
SF
Wang
Li-Xin
LX
Zhou
Qi-Lin
QL
D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
D000480:Alkynes; D000588:Amines; D007097:Imines; D009532:Nickel