Comparison of data used for setting occupational exposure limits.
It has previously been shown that occupational exposure limits (OELs) for the same substance can vary significantly between different standard-setters. The work presented in this paper identifies the steps in the process towards establishing an OEL and how variations in those processes could account for these differences. This study selects for further scrutiny substances for which the level of OELs vary by a factor of 100, focussing on 45 documents concerning 14 substances from eight standard-setters. Several of the OELs studied were more than 20 years old and based on outdated knowledge. Furthermore, different standard-setters sometimes based their OELs on different sets of data, and data availability alone could not explain all differences in the selection of data sets used by standard-setters. While the interpretation of key studies did not differ significantly in standard-setters' documentations, the evaluations of the key studies' quality did. Also, differences concerning the critical effect coincided with differences in the level of OELs for half of the substances.
Schenk
Linda
L
Royal Institute of Technology, Division of Philosophy, Stockholm, Sweden. schenk@kth.se
D015197:Carcinogenicity Tests / Q000592:standards; D005060:Europe; D006801:Humans; D008452:Maximum Allowable Concentration; D012308:Risk Management / Q000458:organization & administration / Q000592:standards*; D020711:Threshold Limit Values; D014481:United States; D014489:United States Occupational Safety and Health Administration