title: Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: a review.
abstract: Adenoid cystic carcinoma (ACC) is an uncommon tumor usually arising in the head and neck region, mainly in the salivary glands. It demonstrates an indolent prolonged course and is characterized by perineural invasion. Primary treatment of local and locoregional disease consists mainly of surgery and/or irradiation. During follow-up these patients frequently develop local recurrences and distant metastases, especially in the lung, although long-term survival is possible. The role of chemotherapy in ACC is limited, and studies with only a limited number of patients are performed. In this article we review the literature on chemotherapy regimens, including monotherapy and combination chemotherapy schedules, as well as the new targeted therapies.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Philipp-University Marburg, Marburg, Germany.
authors.forename: Giorgos
authors.initials: G
authors.lastname: Papaspyrou
authors.forename: Stephan
authors.initials: S
authors.lastname: Hoch
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.forename: Carla
authors.initials: C
authors.lastname: van Herpen
authors.forename: Jochen A
authors.initials: JA
authors.lastname: Werner
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents