Vagotomy suppresses body weight gain in a rat model of gastric banding.
BACKGROUND
The aim of this study was to evaluate the effect of vagotomy on body weight changes after gastric banding.


METHODS
Rats were divided into a sham-operated group (n = 10), a vagotomy alone group (n = 10), a gastric banding alone group (n = 10) and a gastric banding + vagotomy group (n = 10). All groups were given a liquid diet for 5 days after surgery and then given free access to chow. Their body weight was measured through postoperative day (POD) 14, and caloric intake and nitrogen balance were measured until POD 7.


RESULTS
The increase in body weight in the banding + vagotomy group between POD 0 and POD 14 was not significant (12.5 +/- 16.8 g; p = 0.48), and it was less than in the banding alone group (52.8 +/- 3.8 g; p = 0.031). Cumulative caloric intake from POD 5 to POD 7 was less in the banding + vagotomy group than in the banding alone group (158.6 +/- 26.3 vs. 223.9 +/- 8.3 kcal; p = 0.030). Daily nitrogen balance from POD 5 to POD 7 in the banding + vagotomy group was less than in the banding group (337 +/- 77 vs. 540 +/- 42 mg; p = 0.033).


CONCLUSIONS
Vagotomy suppressed body weight gain in the rat model of gastric banding.
Kanno
Hitoshi
H
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Bunkyo, Tokyo, Japan. s6023@nms.ac.jp
Kiyama
Teruo
T
Fujita
Itsuo
I
Kato
Shunji
S
Uchida
Eiji
E
Tajiri
Takashi
T
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D015391:Gastroplasty / Q000379:methods*; D008297:Male; D009765:Obesity / Q000601:surgery*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D016896:Treatment Outcome; D014628:Vagotomy / Q000379:methods*; D015430:Weight Gain; D015431:Weight Loss