Type 2 diabetes and obesity in adults.
There are approximately 2.5 million people in the UK with diabetes; 85-95% of whom have type 2 diabetes. Type 2 diabetes mellitus is characterized by insulin resistance and impaired insulin secretion. As approximately 90% of people with type 2 diabetes are overweight or obese, obesity is seen as a significant contributory factor in its development. This article aims to examine some of the physiological mechanisms by which overweight and obesity contribute to the development of type 2 diabetes, and review some of the approaches to managing overweight and obesity in the person with established type 2 diabetes, including dietary management, the use of reduced carbohydrate diets on glycamic control, anti-diabetes and anti-obesity drugs both in use and in development, and bariatric surgery.
Whitmore
Catherine
C
University of Liverpool.
D000328:Adult; D019440:Anti-Obesity Agents / Q000627:therapeutic use; D050110:Bariatric Surgery; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D004038:Diet, Reducing; D005247:Feeding Behavior; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007333:Insulin Resistance; D008019:Life Style; D024802:Nurse's Role; D009765:Obesity / Q000150:complications* / Q000517:prevention & control*; D056128:Obesity, Abdominal / Q000150:complications; D010353:Patient Education as Topic; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
D019440:Anti-Obesity Agents; D007004:Hypoglycemic Agents