Improved synthesis of 3-(dialkylaminomethyl)-indole in acetic acid aqueous solution under ultrasound irradiation.
Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69-98% yields in acetic acid aqueous solution at 35°C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.
Li
Ji-Tai
JT
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, PR China. lijitai@hbu.cn
Sun
Shao-Feng
SF
Sun
Ming-Xuan
MX
D000085:Acetates / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions; D014465:Ultrasonics; D014867:Water / Q000737:chemistry
D000085:Acetates; D000588:Amines; D007211:Indoles; D012996:Solutions; D014867:Water; D005557:Formaldehyde