title: CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population.
abstract: Non-syndromic cleft lip with or without cleft palate (NSCLP) is the most common craniofacial birth defect. This complex genetic disorder results from interactions between genes and environmental factors. Numerous genes have been reported in studies demonstrating association between the cleft lip and palate phenotypes and the alleles at single-nucleotide polymorphisms (SNPs) within specific genes. Recently, the cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2) has been revealed to be a novel candidate gene for NSCLP. The SNPs rs1546124, rs4783099 and rs16974880 in CRISPLD2 were highly significant in Caucasian and Hispanic multiplex families but showed no association in Colombian and Irish populations. In the current study, we examined these three SNPs in a northern Chinese population and found an association between these polymorphisms and NSCLP in both single-marker and haplotype analyses. Our data further strengthen the conclusion that altered CRISPLD2 is associated with NSCLP susceptibility.
authors.affiliation: Department of Periodontology, School of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Jinna
authors.initials: J
authors.lastname: Shi
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Jiao
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Chunlin
authors.initials: C
authors.lastname: Qin
authors.forename: Fenglin
authors.initials: F
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D003596:Cytosine; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006147:Guanine; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007223:Infant; D050835:Interferon Regulatory Factors / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013941:Thymine; D020506:Untranslated Regions / Q000235:genetics; D055815:Young Adult
chemical_list: C525599:CRISPLD2 protein, human; D015815:Cell Adhesion Molecules; D005819:Genetic Markers; D050835:Interferon Regulatory Factors; D020506:Untranslated Regions; D006147:Guanine; D003596:Cytosine; D013941:Thymine