title: Cytoprotective activities of hydroxycinnamic acid amides of serotonin against oxidative stress-induced damage in HepG2 and HaCaT cells.
abstract: Hydroxycinnamic acid amides of serotonin (HCAAS) [caffeoylserotonin (compound 1), p-coumaroylserotonin (compound 2), and feruloylserotonin (compound 3)] are secondary metabolites produced in plants. The aim of this study was to investigate the cytoprotective effects of HCAAS based on intracellular reactive oxygen radical (ROS) generation, lipid peroxidation, protein carbonylation, and phosphorylation of histone H2AX in H(2)O(2) treated-HepG2 and HaCaT cells. We have shown that HCAAS showed various strong antioxidant activities in hydrogen peroxide treated both cell lines, suggesting that these compounds may play as chemotherapeutic agents for preventing or reducing the oxidative stress-induced diseases.
authors.affiliation: Department of Biotechnology, Environmental Friendly Agricultural Research Center, Bio-Energy Research Center, Chonnam National University, 300 Yongbong-Dong, Buk-Gu, Gwangju 500-757, Republic of Korea.
authors.forename: Jang-Yeol
authors.initials: JY
authors.lastname: Choi
authors.forename: Hyeri
authors.initials: H
authors.lastname: Kim
authors.forename: Yeo-Jin
authors.initials: YJ
authors.lastname: Choi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishihara
authors.forename: Kyoungwhan
authors.initials: K
authors.lastname: Back
authors.forename: Seong-Gene
authors.initials: SG
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D003373:Coumaric Acids / Q000737:chemistry* / Q000494:pharmacology*; D019610:Cytoprotection; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006861:Hydrogen Peroxide; D015227:Lipid Peroxidation; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012701:Serotonin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003373:Coumaric Acids; D016166:Free Radical Scavengers; C468783:H2AX protein, human; D006657:Histones; D017382:Reactive Oxygen Species; D012701:Serotonin; D006861:Hydrogen Peroxide