Inflammasome inhibition as a pathogenic stealth mechanism.
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.
Taxman
Debra J
DJ
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
Huang
Max T-H
MT
Ting
Jenny P-Y
JP
D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D015536:Down-Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000276:immunology* / Q000472:pathogenicity