title: [Clinical analysis of 13 cases with growth hormone deficiency combined with pituitary stalk interruption].
abstract: OBJECTIVE
  To analyze the clinical characteristics of the patients with pituitary stalk interruption syndrome (PSIS), and to achieve better comprehension of this disease.
  
  
  METHODS
  Data of 13 patients with PSIS were retrospectively analyzed for the clinical, laboratory and imaging features.
  
  
  RESULTS
  All the 13 patients (9 male, 4 female) had the chief complaint of growth retardation, 81.5 - 135.0 cm in body height, which were minus two standard deviations below the average of the normal children of same age and same sex. GH stimulated peak levels were all below 5 microg/L; Among them, one was accompanied by delayed sexual development, one by central diabetes insipidus, one was complicated with central hypothyroidism and one was accompanied by central adrenocortical hypofunction.
  
  
  CONCLUSIONS
  The most remarkable clinical manifestations of patients with PSIS were growth retardation, partial or complete adenohypophyseal dysfunction. MRI revealed absence of pituitary stalk or anterior pituitary hypoplasia with ectopic posterior pituitary gland.
authors.affiliation: Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Gao-liang
authors.initials: GL
authors.lastname: Wang
authors.forename: Jun-fen
authors.initials: JF
authors.lastname: Fu
authors.forename: Chun-lin
authors.initials: CL
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Liang
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000002:abnormalities*; D012189:Retrospective Studies
chemical_list: D019382:Human Growth Hormone