title: A systematic review of medication safety outcomes related to drug interaction software.
abstract: BACKGROUND
  Adverse drug events (ADEs) represent an important problem for hospital and primary care. Software that detects potential adverse drug interactions has been widely implemented in an effort to reduce the rate of ADEs. However, the impact of drug interaction detection software (DIS) on patient safety outcomes remains unknown.
  
  
  OBJECTIVE
  To systematically review the literature on DIS in preventing adverse drug events and determine the effectiveness and cost-effectiveness of DIS.
  
  
  METHODS
  A literature search of MEDLINE, EMBASE, CINAHL, IPA and Healthstar, using terms "Computer, Software or Decision Support" combined with "Drug Interactions, Drug Errors or Drug Monitoring" sought English language, post-1990 prospective studies that examined drug interaction (drug-drug) software as an intervention and adverse drug interactions as an outcome. Relevant studies were analyzed using a Bayesian meta-analysis approach.
  
  
  RESULTS
  Of 5848 citations, only four studies met our inclusion criteria. Most of the excluded studies were not prospective or measured only prescriber attitudes, implementation success or changes in workflow. No study examined the impact of drug interaction software exclusively, rather as a component of decision support software. A Bayesian meta-analysis of these studies showed no significant difference in event rate between intervention and control groups (relative risk 0.66, 95% CI 0.33 to 1.18). The posterior median I-squared was 52%.
  
  
  CONCLUSIONS
  No good quality studies address the specific benefits and harms or cost-effectiveness of drug interaction software on medication safety or clinical outcomes. The evidence at present does not support a benefit for these systems or support any policy to widely disseminate their use.
authors.affiliation: Centre for Evaluation of Medicines, Hamilton, Ontario, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Wong
authors.forename: Savio K H
authors.initials: SK
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Holbrook
mesh_terms: D000818:Animals; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000191:economics / Q000517:prevention & control; D006801:Humans; D012984:Software / Q000592:standards*; D016896:Treatment Outcome