title: Rest energy expenditure is decreased during the acute as compared to the recovery phase of sepsis in newborns.
abstract: BACKGROUND
  Little is known with respect to the metabolic response and the requirements of infected newborns. Moreover, the nutritional needs and particularly the energy metabolism of newborns with sepsis are controversial matter. In this investigation we aimed to evaluate the rest energy expenditure (REE) of newborns with bacterial sepsis during the acute and the recovery phases.
  
  
  METHODS
  We studied nineteen neonates (27.3 +/- 17.2 days old) with bacterial sepsis during the acute phase and recovery of their illness. REE was determined by indirect calorimetry and VO2 and VCO2 measured by gas chromatography.
  
  
  RESULTS
  REE significantly increased from 49.4 +/- 13.1 kcal/kg/day during the acute to 68.3 +/- 10.9 kcal/kg/day during recovery phase of sepsis (P < 0.01). Similarly, VO2 (7.4 +/- 1.9 vs 10 +/- 1.5 ml/kg/min) and VCO2 (5.1 +/- 1.7 vs 7.4 +/- 1.5 ml/kg/min) were also increased during the course of the disease (P < 0.01).
  
  
  CONCLUSIONS
  REE was increased during recovery compared to the sepsis phase. REE of septic newborns should be calculated on individualized basis, bearing in mind their metabolic capabilities.
authors.affiliation: Departamento de Pediatria, Universidade de São Paulo (USP), São Paulo, SP, Brasil. rfeferbaum@uol.com.br.
authors.forename: Rubens
authors.initials: R
authors.lastname: Feferbaum
authors.forename: Cláudio
authors.initials: C
authors.lastname: Leone
authors.forename: Arnaldo Af
authors.initials: AA
authors.lastname: Siqueira
authors.forename: Vitor E
authors.initials: VE
authors.lastname: Valenti
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Gallo
authors.forename: Alberto Oa
authors.initials: AO
authors.lastname: Reis
authors.forename: Ary C
authors.initials: AC
authors.lastname: Lopes
authors.forename: Viviane G
authors.initials: VG
authors.lastname: Nascimento
authors.forename: Adriana G
authors.initials: AG
authors.lastname: de Oliveira
authors.forename: Tatiana Dias
authors.initials: TD
authors.lastname: de Carvalho
authors.forename: Rubens
authors.initials: R
authors.lastname: Wajnsztejn
authors.forename: Claudia
authors.initials: C
authors.lastname: de Castro Selestrin
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: de Abreu