Serum levels of adiponectin and leptin in children born small for gestational age: relation to insulin sensitivity parameters.
Children born small for gestational age (SGA) are prone to developing obesity, insulin resistance and type 2 diabetes. Adiponectin and leptin are adipocytokines associated with insulin sensitivity parameters. We aimed to relate serum adiponectin and leptin levels with insulin sensitivity parameters in prepuberal SGA children with and without catch-up growth (SGA+CUG; SGA-CUG, respectively) and to analyze the usefulness of these adipocytokines as early markers of insulin resistance. We analysed adiponectin, proinsulin, leptin, growth factors, insulin, HOMA IR and HOMA beta(cell) in 23 SGA+CUG, 26 SGA-CUG children compared with 48 prepuberal appropiate for gestational age (AGA). SGA children had adiponectin levels comparable to AGA children. Leptin levels were different between sexes, showed to be higher in SGA+CUG group (p=0.040) and these were significantly correlated with insulin sensitivity parameters. These results suggest leptin resistance as an adaptive mechanism to increase energy balance, but an altered functional response of adipocytes cannot be discarded.
Miras
Mirta
M
Servicio de Endocrinologia, Hospital de Niños de la Santisima Trinidad, Córdoba, Argentina.
Ochetti
Mariana
M
Martín
Silvia
S
Silvano
Liliana
L
Sobrero
Gabriela
G
Castro
Laura
L
Onassis
Mariana
M
Tolosa de Talamoni
Nori
N
Pérez
Adriana
A
Picotto
Gabriela
G
Díaz de Barboza
Gabriela
G
Muñoz
Liliana
L
D052242:Adiponectin / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005260:Female; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood* / Q000254:growth & development; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D011384:Proinsulin / Q000097:blood; D011627:Puberty / Q000097:blood* / Q000502:physiology
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011384:Proinsulin