title: Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer.
abstract: BACKGROUND
  The melanoma-associated antigen (MAGE) gene family consists of different expression patterns in various tumor types. They are considered tumor-specific antigens and are ideal targets for cancer immunotherapy. The purpose of this study is to identify the expression profiles of the MAGE family genes in Taiwanese colorectal cancer patients.
  
  
  METHODS
  In this study, a well-constructed chip array platform was used to analyze the expression of the MAGE family genes of 100 colorectal cancer tissues. Statistical analysis of the experimental results and patients' clinical manifestations were also conducted.
  
  
  RESULTS
  The results showed MAGE-A2 (87%), -A7 (83%), -A8 (75%), -A12 (71%), -B2 (75%), -B3 (79%), -D2 (75%), -F1 (79%), and -H1 (70%) were significantly overexpressed genes in colorectal cancer tissues. MAGE-A2 was the most highly overexpressed gene among the MAGE family. MAGE-B3 gene expression is statistically correlated with tumor size, lymph node, and UICC stage. In addition, the overexpression of MAGE-D2 and -H1 genes are statistically correlated to the tumor size and depth, respectively (P < 0.05).
  
  
  CONCLUSIONS
  This is the first comprehensive report to clarify the differential expression profile of whole MAGE family in CRCs, and it might provide some crucial information about the carcinogenesis and progression in Taiwanese patients with CRC.
authors.affiliation: Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Fu-Yen
authors.initials: FY
authors.lastname: Chung
authors.forename: Tian-Lu
authors.initials: TL
authors.lastname: Cheng
authors.forename: Hui-Jen
authors.initials: HJ
authors.lastname: Chang
authors.forename: Hua-Hsien
authors.initials: HH
authors.lastname: Chiu
authors.forename: Ming-Yii
authors.initials: MY
authors.lastname: Huang
authors.forename: Ming-Sung
authors.initials: MS
authors.lastname: Chang
authors.forename: Chung-Chi
authors.initials: CC
authors.lastname: Chen
authors.forename: Ming-Je
authors.initials: MJ
authors.lastname: Yang
authors.forename: Jaw-Yuan
authors.initials: JY
authors.lastname: Wang
authors.forename: Shiu-Ru
authors.initials: SR
authors.lastname: Lin
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D013624:Taiwan
chemical_list: D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins