CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice.
Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-gamma response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naïve mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.
Cunningham
Kelly A
KA
Institute of Health and Biomedical Innovation, Cell & Molecular Biosciences, Faculty of Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Brisbane, QLD 4059, Australia.
Carey
Alison J
AJ
Timms
Peter
P
Beagley
Kenneth W
KW
D000281:Administration, Intranasal; D019264:Adoptive Transfer; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology* / Q000517:prevention & control; D023502:Chlamydia muridarum / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D016207:Cytokines; D007074:Immunoglobulin G