CCR7 is expressed in astrocytes and upregulated after an inflammatory injury.
Neurodegenerative or autoimmune diseases are frequently regulated by chemokines and their receptors, controlling both glial activation and immune cell infiltration. CCL19 and CCL21 have been described to mediate crucial functions during CNS pathological states, regulating both immune cell traffic to the CNS and communication between glia and neurons. Here, we describe the expression pattern and cellular sources of CCR7, receptor of CCL19 and CCL21, in the normal mouse brain. Moreover, we found that CCR7 is upregulated in reactive astrocytes upon intracerebral LPS, regulating early glial reactivity through its ligands CCL19 and CCL21. Our results indicate that CCR7 is playing an important role for the intercellular communication during the inflammatory activation in the CNS.
Gomez-Nicola
Diego
D
Neural Plasticity Group, Functional and Systems Neurobiology Department, Cajal Institute, CSIC, Avda Doctor Arce, 37, 28002, Madrid, Spain. dgomez@cajal.csic.es
Pallas-Bazarra
Noemí
N
Valle-Argos
Beatriz
B
Nieto-Sampedro
Manuel
M
D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology*; D002450:Cell Communication / Q000235:genetics / Q000276:immunology; D002478:Cells, Cultured; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D055495:Neurogenesis / Q000235:genetics / Q000276:immunology; D054400:Receptors, CCR7 / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology; D015854:Up-Regulation / Q000276:immunology*
C515371:Ccr7 protein, mouse; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D054400:Receptors, CCR7