title: Imaging-genetics applications in child psychiatry.
abstract: OBJECTIVE
  To place imaging-genetics research in the context of child psychiatry.
  
  
  METHODS
  A conceptual overview is provided, followed by discussion of specific research examples.
  
  
  RESULTS
  Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.
  
  
  CONCLUSIONS
  Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.
authors.affiliation: National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA. daniel.pine@nih.gov
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.forename: Monique
authors.initials: M
authors.lastname: Ernst
authors.forename: Ellen
authors.initials: E
authors.lastname: Leibenluft
mesh_terms: D000293:Adolescent; D000818:Animals; D001921:Brain / Q000503:physiopathology; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D008995:Monoamine Oxidase / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase