[Research progress in modification of histone lysine methylation and congenital heart defect].
Histone modification is an important component of epigenetic regulation, which can regulate eukaryotic gene expression by changing the structure of chromatin and interacting with other regulatory proteins. Abnormal histone modifications may lead to a variety of diseases, while the reversibility of histone modification provides a new way of thinking for treatment of these diseases. In this paper, we discussed the mechanism of histone lysine methylation related to congenital heart defect in order to provide a useful reference for researchers working in this area.
Sheng
Wei
W
Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical College, Fudan University, Birth Defects Research Center, Fudan University, Shanghai 200053, China. sheng4616@hotmail.com
Ma
Duan
D
D044127:Epigenesis, Genetic / Q000235:genetics; D006330:Heart Defects, Congenital / Q000235:genetics*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D008745:Methylation
D006657:Histones; D008239:Lysine