Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application.
In this review, isolation and characterization of several kidney-derived molecules are described, namely carbonic anhydrase XIV, cysteine-rich protein 61, and kidney-liver-specific immunoglobulin-like protein. Features of neutrophil gelatinase-associated lipocalin (LCN2 or human neutrophil lipocalin) as a kidney differentiation inducer and renal injury biomarker and also as an iron-carrier protein are also summarized. Furthermore, the concepts of forest fire theory and the biology of siderophore-binding proteins are discussed.
Mori
Kiyoshi
K
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan. keyem@kuhp.kyoto-u.ac.jp
Mukoyama
Masashi
M
Nakao
Kazuwa
K
D000209:Acute-Phase Proteins / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D002256:Carbonic Anhydrases / Q000032:analysis*; D055515:Cysteine-Rich Protein 61 / Q000032:analysis*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis*; D007668:Kidney / Q000196:embryology / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D000071068:Lipocalin-2; D054834:Lipocalins / Q000032:analysis* / Q000378:metabolism; D008565:Membrane Proteins / Q000032:analysis*; D051379:Mice; D015513:Oncogene Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000378:metabolism; D015398:Signal Transduction
D000209:Acute-Phase Proteins; D055515:Cysteine-Rich Protein 61; D036341:Intercellular Signaling Peptides and Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008565:Membrane Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; C442242:Timd2 protein, mouse; C071332:Lcn2 protein, mouse; D002256:Carbonic Anhydrases; C466621:carbonic anhydrase XIV