High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats.
The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.
Klavir
Oded
O
Department of Psychology, Tel Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel.
Winter
Christine
C
Joel
Daphna
D
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003192:Compulsive Behavior / Q000503:physiopathology* / Q000628:therapy; D046690:Deep Brain Stimulation / Q000379:methods*; D004195:Disease Models, Animal; D020392:Entopeduncular Nucleus / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D005917:Globus Pallidus / Q000502:physiology*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology / Q000628:therapy; D051381:Rats; D017207:Rats, Sprague-Dawley