Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation.
A novel and highly efficient one-pot three-component synthesis of alpha-aminophosphonates under neat condition was developed. By employing this method, hybrid compounds of aminophosphonate with pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline and dimethyl phosphite. The antiviral and antileishmanial activities of these novel hybrid compounds were also studied but none were found to be active.
Zhang
Xinying
X
School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan, P. R. China.
Qu
Yingying
Y
Fan
Xuesen
X
Bores
C
C
Feng
Dong
D
Andrei
Graciela
G
Snoeck
Robert
R
De Clercq
Erik
E
Loiseau
Philippe M
PM
D000814:Aniline Compounds / Q000737:chemistry; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D017905:Phosphites / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000737:chemistry*
D000814:Aniline Compounds; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D063065:Organophosphonates; D017905:Phosphites; D011741:Pyrimidine Nucleosides; C061519:5-formyl-2'-deoxyuridine; C023650:aniline; C047356:dimethyl hydrogen phosphite; D003857:Deoxyuridine