title: Redox electrodeposition polymers: adaptation of the redox potential of polymer-bound Os complexes for bioanalytical applications.
abstract: The design of polymers carrying suitable ligands for coordinating Os complexes in ligand exchange reactions against labile chloro ligands is a strategy for the synthesis of redox polymers with bound Os centers which exhibit a wide variation in their redox potential. This strategy is applied to polymers with an additional variation of the properties of the polymer backbone with respect to pH-dependent solubility, monomer composition, hydrophilicity etc. A library of Os-complex-modified electrodeposition polymers was synthesized and initially tested with respect to their electron-transfer ability in combination with enzymes such as glucose oxidase, cellobiose dehydrogenase, and PQQ-dependent glucose dehydrogenase entrapped during the pH-induced deposition process. The different polymer-bound Os complexes in a library containing 50 different redox polymers allowed the statistical evaluation of the impact of an individual ligand to the overall redox potential of an Os complex. Using a simple linear regression algorithm prediction of the redox potential of Os complexes becomes feasible. Thus, a redox polymer can now be designed to optimally interact in electron-transfer reactions with a selected enzyme.
authors.affiliation: Analytische Chemie-Elektroanalytik & Sensorik, Ruhr-Universität Bochum, Universitätsstr. 150, 44780 Bochum, Germany.
authors.forename: Dmitrii A
authors.initials: DA
authors.lastname: Guschin
authors.forename: John
authors.initials: J
authors.lastname: Castillo
authors.forename: Nina
authors.initials: N
authors.lastname: Dimcheva
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schuhmann
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D004595:Electroplating; D004800:Enzymes, Immobilized / Q000737:chemistry; D017892:Osmium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*
chemical_list: D004800:Enzymes, Immobilized; D017892:Osmium Compounds; D011108:Polymers