Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis.
Twelve healthy horses were subject to the monoioidoacetate (MIA) carpitis model, which was allowed to develop for 7 days. The horses were then randomly divided into two groups. Group A (control) received an intramuscular injection of normal saline every 4 days for a total of seven injections while group B received 500 mg of a PSGAG (SYNTEX CSY36) intramuscularly every 4 days for seven treatments. Efficacy of the PSGAG was evaluated by three clinical outcomes: lameness score, carpal circumference and maximum carpal flexion. Clinical outcomes were measured on days -8 (previous to carpitis induction), 0 (previous to drug treatment), 7, 14, 21, 28 and 35. Areas under the curve clinical outcome as function of time were built and used as variables for the statistical analysis. There was less joint circumference enlargement and lameness and greater carpal flexion in PSGAG-treated horses compared with that in controls. The studied compound has demonstrated to be efficacious on the treatment of a chemically induced carpitis in horses.
Verde
C
C
Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, CONICET, La Plata, Argentina.
Ferrante
M
M
Simpson
M I
MI
Babusci
M
M
Broglia
G
G
Landoni
M F
MF
D000818:Animals; D001168:Arthritis / Q000188:drug therapy / Q000662:veterinary*; D050824:Carpal Joints / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy* / Q000473:pathology; D006736:Horses; D007273:Injections, Intramuscular / Q000662:veterinary; D007794:Lameness, Animal / Q000188:drug therapy*; D016896:Treatment Outcome
D006025:Glycosaminoglycans; C013786:A73025