title: A novel function of mtDNA: its involvement in metastasis.
abstract: It has been controversial whether mtDNA mutations are responsible for oncogenic transformation (normal cells to develop tumors) and for malignant progression (tumor cells to develop metastases). To clarify this issue, we created transmitochondrial cybrids with mtDNA exchanged between mouse tumor cells that express different metastatic phenotypes. The G13997A mutation in the ND6 gene of mtDNA from high-metastatic tumor cells reversibly controlled development of metastases by overproduction of reactive oxygen species (ROS). The mtDNA-mediated reversible control of metastasis reveals a novel function of mtDNA, and suggests that ROS scavengers may be therapeutically effective in suppressing metastasis.
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D004272:DNA, Mitochondrial / Q000502:physiology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009362:Neoplasm Metastasis; D010641:Phenotype; D017382:Reactive Oxygen Species
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species