Phenytoin-associated hypersensitivity syndrome with features of DRESS and TEN/SJS.
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, toxic epidermal necrolysis (TEN), and Stevens-Johnson syndrome (SJS) are rare and life-threatening conditions that may be precipitated by anticonvulsive agents. We describe a patient with overlapping features of these hypersensitivity syndromes.
Viera
Martha H
MH
Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Florida 33136, USA. mviera2@med.miami.edu
Perez
Oliver A
OA
Patel
Jitendrakumar K
JK
Jones
Isaac
I
Berman
Brian
B
D000927:Anticonvulsants / Q000009:adverse effects; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004802:Eosinophilia / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D013577:Syndrome
D000927:Anticonvulsants; D010672:Phenytoin