Pneumococci: immunology of the innate host response.
Despite the development of vaccines and antibiotics, Streptococcus pneumoniae (the pneumococcus) continues to be a major cause of human morbidity and mortality throughout the world. In recent years our understanding of how the host innate immune system recognizes and responds to pneumococcal infection has advanced significantly. Herein, we highlight some of the key features of the innate response to the pneumococcus.
Paterson
Gavin K
GK
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
Orihuela
Carlos J
CJ
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D003167:Complement Activation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology; D011008:Pneumococcal Infections / Q000276:immunology* / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000276:immunology* / Q000382:microbiology; D051116:Receptors, Scavenger / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
D016207:Cytokines; D022242:Pneumococcal Vaccines; D051116:Receptors, Scavenger; D051193:Toll-Like Receptors