title: Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases.
abstract: OBJECTIVE
  The aims of this study were to evaluate survival and ovarian prognosis in patients treated for ovarian germ cell tumor (OGCT) and to propose a decision-making protocol.
  
  
  METHODS
  Charts of girls operated on for OGCT from 1976 up to 2009 were reviewed retrospectively. Tumor characteristics were assessed by tumor markers, imaging, and pathology.
  
  
  RESULTS
  Charts were available in 71 children presenting 75 OGCT. Tumors were benign in 58 cases and malignant in 17 cases. The average of the largest diameter of benign OGCT was significantly lower than that of malignant OGCT (76.5 +/- 49 mm versus 169 +/- 54 mm, P < .0001). Ovarian-sparing tumorectomy was carried out in 27 benign OGCT; 23 (85%) preserved ovaries were follicular. Malignant OGCTs were managed according to the protocols of the French Society for Pediatric Oncology. Bilateral oophorectomy had to be performed in 2 children. One patient presented a recurrence and 1 died.
  
  
  CONCLUSIONS
  In our series, both benign and malignant OGCTs have a good prognosis. A 75-mm cutoff size is proposed as an important criterion to preoperatively differentiate between benign and malignant tumors. In benign OGCT, ovarian-sparing tumorectomy leads to preserve ovaries in approximately 85% of cases, and in malignant OGCT, high survival rate has been obtained.
authors.affiliation: Department of Pediatric Surgery, Childen's Hospital, 31059 Toulouse Cedex 9, France. pvaysse@cict.fr
authors.forename: Charlotte
authors.initials: C
authors.lastname: Vaysse
authors.forename: Martine
authors.initials: M
authors.lastname: Delsol
authors.forename: Luana
authors.initials: L
authors.lastname: Carfagna
authors.forename: Ourdia
authors.initials: O
authors.lastname: Bouali
authors.forename: Sophie
authors.initials: S
authors.lastname: Combelles
authors.forename: Frederique
authors.initials: F
authors.lastname: Lemasson
authors.forename: Aurélie
authors.initials: A
authors.lastname: Le Mandat
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Castex
authors.forename: Marlène
authors.initials: M
authors.lastname: Pasquet
authors.forename: Jacques
authors.initials: J
authors.lastname: Moscovici
authors.forename: Jacques
authors.initials: J
authors.lastname: Guitard
authors.forename: Catherine
authors.initials: C
authors.lastname: Pienkowski
authors.forename: Hervé
authors.initials: H
authors.lastname: Rubie
authors.forename: Philippe
authors.initials: P
authors.lastname: Galinier
authors.forename: Philippe
authors.initials: P
authors.lastname: Vaysse
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D007223:Infant; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D010052:Ovariectomy; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor