The lipid A receptor.
The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation. TLR4 associates with MD-2, which is required for surface expression and recognition of lipid A. In addition, the RP 10S-MD-1 complex mediates TLR4-mediated response in B cells and negatively regulates TLR4-mediated response in dendritic cells. Thus, lipid A receptor's function varies among cell populations.
Takeda
Kiyoshi
K
Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ktakeda@bioreg.kyushu-u.ac.jp
D000818:Animals; D006801:Humans; D008050:Lipid A / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D008050:Lipid A; D011956:Receptors, Cell Surface