title: Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.
abstract: OBJECTIVE
  Ocular surface squamous neoplasia (OSSN) in sub-Saharan countries is an aggressive tumor that affects younger patients and appears to be increasing in incidence. There are data to suggest the association of this disease with solar radiation exposure, HIV, and human papilloma virus (HPV). This trend possibly reflects the association of the high incidence of HIV, concomitant high incidence of exposure to HPV, and the solar radiation exposure that people in this region of the world receive. We undertook a PubMed search with the terms 'ocular surface squamous neoplasia', 'conjunctival carcinoma', 'HIV' and 'HPV', and 'sub-Saharan/Africa' to ascertain the scope of the problem and to review the available data, with an emphasis on publications of 2009 and the first quarter of 2010.
  
  
  RESULTS
  There is increasing evidence of a significant association between HIV seropositivity and OSSN. The role of HPV as contributing to the cause of OSSN is being investigated.
  
  
  CONCLUSIONS
  Patients with conjunctival cancer in sub-Saharan Africa are typically younger and more than 50% have underlying HIV infection. Initial presentation can be asymptomatic; however, many of these patients have advanced disease before they seek medical help and OSSN appears to have a more aggressive clinical course in sub-Saharan Africa. Treatment in Africa is primarily surgical. Chemotherapy and antiviral agents have been used. A diagnosis of OSSN in younger patients in sub-Saharan Africa should prompt HIV serotesting.
authors.affiliation: Department of Medicine, Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV 26506, USA.
authors.forename: Govardhanan
authors.initials: G
authors.lastname: Nagaiah
authors.forename: Christy
authors.initials: C
authors.lastname: Stotler
authors.forename: Jackson
authors.initials: J
authors.lastname: Orem
authors.forename: Walter O
authors.initials: WO
authors.lastname: Mwanda
authors.forename: Scot C
authors.initials: SC
authors.lastname: Remick
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D005134:Eye Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D011379:Prognosis