[Diagnostic value of parameters of glucose metabolism as screening tests for insulinoma].
OBJECTIVE
To analyze the diagnostic value of employing the parameters of glucose metabolism as screening tests for insulinoma.


METHODS
Blood glucose profiles within 72 h were recorded by continuous glucose monitoring system (CGMS). Blood samples were collected to detect the HbA1c and GA levels. All subjects received a delayed 75 g oral glucose tolerance test (OGTT) and a simultaneous insulin and C peptide releasing test.


RESULTS
Levels of HbA1c [(4.49 +/- 0.63)% vs (5.60 +/- 0.25)%, (5.28 +/- 0.48)%], fasting blood glucose [(3.44 +/- 0.78) mmol/L vs (4.82 +/- 0.35) mmol/L, (4.70 +/- 0.49) mmol/L] and the lowest blood glucose with CGMS [(2.31 +/- 0.24) mmol/L vs (3.28 +/- 0.45) mmol/L, (3.28 +/- 0.99) mmol/L] in insulinoma group were significantly lower than that in impaired glucose tolerance or diabetic patient group and functional hypoglycemia group (P value < 0.05). On the contrary, the levels of IRI (insulin release index) (0.38 +/- 0.07 vs 0.11 +/- 0.06, 0.16 +/- 0.03), CPI (C-peptide index) (0.03 +/- 0.01 vs 0.02 +/- 0.01, 0.02 +/- 0.01) in insulinoma group were higher than those of two other groups (P value < 0.05). Areas of ROC curve were 0.875, 0.955, 0.974, 0.848, 0.916 respectively as screening tests for insulinoma.


CONCLUSIONS
The measurements of HbA1c, fasting blood glucose, IRI, CPI and the lowest blood glucose with CGMS might be useful screening tools to identify insulinoma.
Han
Jun-feng
JF
Department of Endocrinology & Metabolism, Affiliated Sixth People's Hospital of Shanghai Jiaotong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key laboratory of Diabetes Mellitus, Shanghai 200233, China.
Zhang
Feng
F
Bao
Yu-qian
YQ
Zhou
Jian
J
Lu
Wei
W
Lu
Jun-xi
JX
Jia
Wei-ping
WP
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D001786:Blood Glucose