title: Cloning, expression, and polymorphisms of natural killer cell receptor NCR1 in pigs.
abstract: NCR1 (NKp46) is expressed on the surfaces of natural killer cells and recognizes hemagglutinin on the influenza virus. We cloned the NCR1 gene in pigs and found that porcine NCR1 was minimally expressed in the thymus, suggesting that NCR1 could be a useful marker of natural killer cells in pigs. We observed three nonsynonymous single nucleotide polymorphisms and one deletion of three nucleotides in the coding sequence of porcine NCR1; these may affect the function of NCR1. The polymorphisms detected here may be useful markers for breeding for influenza resistance in pigs.
authors.affiliation: Kagoshima University, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Jozaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shinkai
authors.forename: Takeya
authors.initials: T
authors.lastname: Morozumi
authors.forename: Maiko
authors.initials: M
authors.lastname: Tanaka-Matsuda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Eguchi-Ogawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Wada
authors.forename: Hirohide
authors.initials: H
authors.lastname: Uenishi
mesh_terms: D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D003001:Cloning, Molecular; D005260:Female; D014644:Genetic Variation; D008297:Male; D008969:Molecular Sequence Data; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D012313:RNA / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013552:Swine / Q000235:genetics* / Q000276:immunology; D013950:Thymus Gland / Q000378:metabolism / Q000502:physiology
chemical_list: D055627:Natural Cytotoxicity Triggering Receptor 1; D012313:RNA