title: Isotretinoin effect on alveolar repair after exodontia--a study in rats.
abstract: OBJECTIVE
  To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats.
  
  
  METHODS
  Wistar rats (60-day-old) were assigned to control (CG, n = 12) and experimental (EG, n = 20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy.
  
  
  RESULTS
  There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90.
  
  
  CONCLUSIONS
  Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas, Rua Gonçalves Chaves, 3.657/401 B, Pelotas, Rio Grande do Sul, Brazil. betabergoli@hotmail.com
authors.forename: Roberta Dalmolin
authors.initials: RD
authors.lastname: Bergoli
authors.forename: Otacilio Luiz
authors.initials: OL
authors.lastname: Chagas Junior
authors.forename: Carlos Eduardo Chrzanowski Pereira
authors.initials: CE
authors.lastname: de Souza
authors.forename: Beatriz Farias
authors.initials: BF
authors.lastname: Vogt
authors.forename: Henrique Telles Ramos
authors.initials: HT
authors.lastname: de Oliveira
authors.forename: Adriana
authors.initials: A
authors.lastname: Etges
authors.forename: Daniela Nascimento
authors.initials: DN
authors.lastname: Silva
mesh_terms: D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D003879:Dermatologic Agents / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D007180:Incisor / Q000601:surgery*; D015474:Isotretinoin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin; D002118:Calcium