title: [Platelet inhibition with prasugrel].
abstract: Platelet activation plays a pivotal role in the pathogenesis of coronary artery disease. The long-term benefit of dual anti-platelet therapy with clopidogrel and aspirin is well established for patients with acute coronary syndrome and for secondary prophylaxis of coronary artery disease. This review discusses latest developments in the field of the thienopyridines. Particularly, we focus on the evidence-based use of prasugrel or prasugrel versus clopidogrel in clinical practice.
authors.affiliation: Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln. Natig.Gassanov@uk-koeln.de
authors.forename: N
authors.initials: N
authors.lastname: Gassanov
authors.forename: E
authors.initials: E
authors.lastname: Caglayan
authors.forename: A M
authors.initials: AM
authors.lastname: Nia
authors.forename: E
authors.initials: E
authors.lastname: Erdmann
authors.forename: F
authors.initials: F
authors.lastname: Er
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy*; D000284:Administration, Oral; D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy; D001682:Biological Availability; D000077144:Clopidogrel; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology; D010879:Piperazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000068799:Prasugrel Hydrochloride; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D013876:Thiophenes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D013876:Thiophenes; D000077144:Clopidogrel; D000068799:Prasugrel Hydrochloride; D013988:Ticlopidine