title: The prognostic value of mean platelet volume in decompensated heart failure.
abstract: BACKGROUND
  Congestive heart failure (CHF) is a major public health problem that is related to substantial morbidity, impaired quality of life and diminished survival. Mean platelet volume (MPV) is an indicator of platelet activation.
  
  
  OBJECTIVE
  To investigate whether there is a difference of MPV in patients with decompensated and stable heart failure (SHF), and test the prognostic value of MPV in decompensated heart failure (DHF).
  
  
  METHODS
  136 consecutive patients with DHF were enrolled. 71 with SHF were also enrolled for comparison. Patients were followed up for a mean of 18±12 months. The primary endpoint was death from any cause. Clinical characteristics of patients with DHF who died during follow-up were compared with the those of the survivors.
  
  
  RESULTS
  MPV was significantly higher in DHF group than in the SHF group. 71 patients died during the follow-up period (18±12 months). Comparison with survivors revealed that mortality was associated with age, systolic blood pressure, pulmonary artery pressure, serum creatinine, urea and MPV. MPV was determined as an independent risk factor for mortality (OR 1.553, 95% CI 1.024 to 2.354, p=0.038). Receiver operating characteristic analysis showed that MPV level on admission was a predictor of mortality (area under the curve (AUC) for in-hospital mortality was 0.716 (95% CI 0.632 to 0.789, p=0.003) and AUC for 6-month mortality was 0.815 (95% CI 0.74 to 0.877, p<0.001), respectively).
  
  
  CONCLUSIONS
  MPV is increased in patients with DHF. Also, MPV on admission is an independent predictor of in-hospital mortality and 6-month mortality.
authors.affiliation: Duzce University, Düzce Medical School, Department of Emergency Medicine, Konuralp Düzce, Turkey.
authors.forename: Hayati
authors.initials: H
authors.lastname: Kandis
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozhan
authors.forename: Serkan
authors.initials: S
authors.lastname: Ordu
authors.forename: Ismail
authors.initials: I
authors.lastname: Erden
authors.forename: Onur
authors.initials: O
authors.lastname: Caglar
authors.forename: Cengiz
authors.initials: C
authors.lastname: Basar
authors.forename: Subhan
authors.initials: S
authors.lastname: Yalcin
authors.forename: Recai
authors.initials: R
authors.lastname: Alemdar
authors.forename: Mesut
authors.initials: M
authors.lastname: Aydin
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D048429:Cell Size; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D015415:Biomarkers