title: Synthesis and antibacterial activity of novel enolphosphate derivatives.
abstract: A new class of enolphosphates derivatives, the 1-alkenyldiphosphates, was designed and a rapid and efficient synthesis for these compounds was developed. These new molecules showed interesting in vitro antibacterial activities (MIC) against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative pathogens including Pseudomonas aeruginosa and Escherichia coli.
authors.affiliation: CEFE UMR, Montpellier, France. claude.grison@cefe.cnrs.fr
authors.forename: Claude
authors.initials: C
authors.lastname: Grison
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barthes
authors.forename: Chantal
authors.initials: C
authors.lastname: Finance
authors.forename: Raphael E
authors.initials: RE
authors.lastname: Duval
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010755:Organophosphates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D010755:Organophosphates