title: Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disorders.
abstract: Excess production of melanin or its abnormal distribution, or both, can cause irregular hyperpigmentation of the skin, leading to melasma and age spots. To date, various quasi-drugs that prevent or improve hyperpigmentary disorders have been developed and officially approved by the Ministry of Health, Labor and Welfare of Japan. Many of these inhibit the activity of tyrosinase, an enzyme required for melanin synthesis, for example, by competitive or non-competitive inhibition of its catalytic activity, by inhibiting its maturation, or by accelerating its degradation. In this review, we categorize the quasi-drugs developed in Japan to prevent or treat hyperpigmentary disorders, or both, and discuss perspectives for future development.
authors.affiliation: Skin Aging and Photo-aging Research Center, Doshisha University, Kizugawa, Kyoto 619-0225, Japan; E-Mail: mm_ichihashi@hotmail.com.
authors.forename: Hideya
authors.initials: H
authors.lastname: Ando
authors.forename: Mary S
authors.initials: MS
authors.lastname: Matsui
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ichihashi
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy* / Q000517:prevention & control; D007564:Japan