The lateral compartmentation of the yeast plasma membrane.
The plasma membrane of Saccharomyces cerevisiae contains large microdomains enriched in ergosterol, which house at least nine integral proteins, including proton symporters. The domains adopt a characteristic structure of furrow-like invaginations typically seen in freeze-fracture pictures of fungal cells. Being stable for the time comparable with the cell cycle duration, they might be considered as fixed islands (rafts) in an otherwise fluid yeast plasma membrane. Rapidly moving endocytic marker proteins avoid the microdomains; the domain-accumulated proton symporters consequently show a reduced rate of substrate-induced endocytosis and turnover.
Malinsky
Jan
J
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic. malinsky@biomed.cas.cz
Opekarová
Miroslava
M
Tanner
Widmar
W
D026923:Amino Acid Transport Systems, Basic / Q000378:metabolism; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D021962:Membrane Microdomains / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D018613:Microscopy, Confocal; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D026923:Amino Acid Transport Systems, Basic; C502212:CAN1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins