title: Exposure to selected endocrine disruptors and neonatal outcome of 86 healthy boys from Nice area (France).
abstract: In utero and lactational exposure to endocrine disruptors is thought to be potentially harmful on fetal and infant development. Data of exposure in France is scarce. This is a prospective study with (1) collection of 84 cord bloods (CB) and 69 milks from 86 mothers delivering healthy boys (gestational age >or= 34 weeks) at two maternity wards in Southern France, between 2002 and 2005 and (2) screening for 15 xenobiotics with anti-androgenic and/or estrogenic effects: DDE, 7 PCBs, dibutylphthalate and its metabolite mBP, HCB, lindane, linuron, procymidone and vinclozoline. Correlations were made with delivery and neonatal outcomes. All CB and milks were contaminated by one or more xenobiotics (mainly PCBs, DDE, HCB, and phthalates) with good correlation between CB and milk concentrations. Compared to other geographical areas, exposure was usually in the lower bracket. Milk [PCB180] was associated with lower birth weight. Infant head circumference correlated negatively with [HCB] and positively with [mBP] in CB. There was a similar but not significant trend for birth weight and length. [DDE] in milk was higher in older mothers and in women born in Africa. In utero and lactational exposure is ubiquitous in our area. Contamination of milk with HCB, mBP, and PCB 180 showed weak correlations with infant growth. This snapshot of exposure in an area with no major industry will serve for further monitoring.
authors.affiliation: Endocrinology Department, Hôpital l'Archet, CHU Nice, 06200 Nice, France. brucker-davis.f@chu-nice.fr
authors.forename: Françoise
authors.initials: F
authors.lastname: Brucker-Davis
authors.forename: Kathy
authors.initials: K
authors.lastname: Wagner-Mahler
authors.forename: Laure
authors.initials: L
authors.lastname: Bornebusch
authors.forename: Isabelle
authors.initials: I
authors.lastname: Delattre
authors.forename: Patricia
authors.initials: P
authors.lastname: Ferrari
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Gal
authors.forename: Mireille
authors.initials: M
authors.lastname: Boda-Buccino
authors.forename: Patricia
authors.initials: P
authors.lastname: Pacini
authors.forename: Camille
authors.initials: C
authors.lastname: Tommasi
authors.forename: Pierre
authors.initials: P
authors.lastname: Azuar
authors.forename: André
authors.initials: A
authors.lastname: Bongain
authors.forename: Patrick
authors.initials: P
authors.lastname: Fénichel
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D052244:Endocrine Disruptors / Q000378:metabolism*; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004784:Environmental Monitoring; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005602:France; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D052244:Endocrine Disruptors; D015262:Xenobiotics