title: Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated beta-amino ester stereoisomers.
abstract: Enantiomerically enriched hydroxy-substituted beta-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee > or = 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 degrees C with 0.5 equiv. of added H(2)O as nucleophile.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.
authors.forename: Eniko
authors.initials: E
authors.lastname: Forró
authors.forename: László
authors.initials: L
authors.lastname: Schönstein
authors.forename: Loránd
authors.initials: L
authors.lastname: Kiss
authors.forename: Alberto
authors.initials: A
authors.lastname: Vega-Peñaloza
authors.forename: Eusebio
authors.initials: E
authors.lastname: Juaristi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp
mesh_terms: D000598:Amino Acids, Cyclic / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000598:Amino Acids, Cyclic; D004952:Esters