Evaluation of blood pressure in Spontaneously Diabetic Torii-Lepr(fa) rats.
The Spontaneously Diabetic Torii-Lepr(fa) (SDT-fa/fa) rat, a new model of obese type 2 diabetes, shows obesity, hyperglycemia, and hyperlipidemia from 6 weeks of age. Diabetic complications such as nephropathy and cataract are observed with aging; however, blood pressure change with age has not previously been examined. In this study, blood pressure was periodically measured and the change was investigated. Blood pressure in male SDT-fa/fa rats was elevated at 8, 16, and 24 weeks of age, whereas the heart rate was not changed. In addition to hyperglycemia, hyperlipidemia, and proteinuria, hyperleptinemia and increased urine angiotensinogen were observed in SDT-fa/fa rats. Blood pressure and heart rate in the male original SDT (SDT-+/+) rat did not significantly change. In conclusion, the SDT-fa/fa rat is a promising model, showing significant hypertension with diabetes mellitus.
Ishii
Yukihito
Y
Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan.
Maki
Mimi
M
Yamamoto
Hiromi
H
Sasase
Tomohiko
T
Kakutani
Makoto
M
Ohta
Takeshi
T
D000808:Angiotensinogen / Q000652:urine; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D006339:Heart Rate / Q000502:physiology; D006943:Hyperglycemia / Q000235:genetics / Q000503:physiopathology; D006949:Hyperlipidemias / Q000235:genetics / Q000503:physiopathology; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D011507:Proteinuria / Q000235:genetics / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D020738:Leptin; D000808:Angiotensinogen