title: Intracranial and spinal metastases from eccrine mucinous carcinoma: case report.
abstract: BACKGROUND
  Mucinous eccrine carcinoma (MEC) is a rare but distinct type of sweat gland tumor. MECs tend to recur locally, and their spread to distant organs is very uncommon. This article describes the first case of MEC metastasizing to the brain and the spine.
  
  
  METHODS
  A 45-year-old female presented with a 2-year history of a scalp mass in the occipital area with lymph node spread. She underwent excision of the mass and neck lymph node dissection. Pathology confirmed the diagnosis of MEC. Postoperatively, she received radiation to the involved areas. Four years later the patient presented with left hemiparesis and underwent craniotomy for gross total resection of the metastasis. This recurred after 2.5 years and she underwent another craniotomy for gross total resection followed by whole brain radiation. In addition, the patient had metastases to T11 vertebral body and the left C6 to 7 neural foramen. Moreover, the patient developed leptomeningeal disease in the spine. The metastases to the spine were treated with radiation therapy. The patient died 1.5 years later.
  
  
  CONCLUSIONS
  Even though it is rare for MEC to spread to distant organs, physicians should be aware of the risk of metastatic invasion of the brain and spine and be vigilant about surveillance of these sites. MEC metastases to the brain should be treated aggressively with surgical resection followed by stereotactic radiosurgery to the tumor bed. Spine metastases should be treated with a combination of surgery and image-guided radiation therapy, depending on the degree of cord compression from epidural metastatic disease.
authors.affiliation: Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. rishinsheth@gmail.com
authors.forename: Rishi N
authors.initials: RN
authors.lastname: Sheth
authors.forename: Dimitris G
authors.initials: DG
authors.lastname: Placantonakis
authors.forename: Philip H
authors.initials: PH
authors.lastname: Gutin
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000556:secondary*; D001932:Brain Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D013125:Spinal Neoplasms / Q000556:secondary*; D013544:Sweat Gland Neoplasms / Q000473:pathology*