[Prenatal exposure to organochlorine pesticides and cryptorchidism].
Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ss-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid-based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ss-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pp'DDT and ss-HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fetal development.
Bustamante Montes
Lília Patrícia
LP
Universidad Autónoma del Estado de México, Toluca, Estado de México. patriciiab@yahoo.com.mx
Waliszewski
Stefan
S
Hernández-Valero
María
M
Sanín-Aguirre
Luz
L
Infanzón-Ruiz
Rosa Maria
RM
Jañas
Arlette García
AG
D003456:Cryptorchidism / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood / Q000633:toxicity*; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*
D006843:Hydrocarbons, Chlorinated; D010575:Pesticides