Fine regulation of Saccharomyces cerevisiae MAPK pathways by post-translational modifications.
Saccharomyces cerevisiae has been widely used as a model eukaryotic organism to elucidate the molecular mechanisms that operate upon activation of signalling pathways. For over two decades, many clues to the regulation of mitogen-activated protein kinase (MAPK) pathways have derived from basic research in yeast. Here we review aspects of MAPK pathway fine-tuning, such as the functional implication of feedback loops or regulatory inputs from other pathways, mediated by post-transcriptional modifications on their components. The impact of recent phosphoproteomic approaches in this particular field is also discussed.
Molina
María
M
Dpto. de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Pza. Ramón y Cajal s/n, 28040 Madrid, Spain. molmifa@farm.ucm.es
Cid
Víctor J
VJ
Martín
Humberto
H
D002473:Cell Wall / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D054875:Ubiquitination
D005656:Fungal Proteins; D020928:Mitogen-Activated Protein Kinases