title: Targeting TOR dependence in cancer.
abstract: A challenge in cancer therapy has been to identify targets whose function is essential for survival of malignant cells but not normal cells. This Perspective discusses recent evidence that novel inhibitors of the kinase TOR can provide an unprecedented balance of anti-cancer efficacy and tolerability.
authors.affiliation: Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Janes
authors.forename: David A
authors.initials: DA
authors.lastname: Fruman
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C500984:CRTC1 protein, human; C493245:CRTC2 protein, human; D014157:Transcription Factors