title: The effects of a brief relaxation program on symptom distress and heart rate variability in cancer patients.
abstract: OBJECTIVE
  To determine whether a 15-minute, one-time guided relaxation program for cancer patients could improve symptom distress as measured by the Edmonton Symptom Assessment System (ESAS). In addition, we were interested in characterizing the changes of the autonomic nervous system, as demonstrated by heart rate variability (HRV) high-frequency (HF) spectral analysis, before and after this relaxation program.
  
  
  METHODS
  Nonrandomized pilot study.
  
  
  METHODS
  Comprehensive cancer center.
  
  
  METHODS
  Twenty cancer patients underwent a 15-minute relaxation program. The ESAS and a 5-minute HRV recording were completed before and after the relaxation program.
  
  
  METHODS
  The differences between the pre- and post-summed ESAS score and HRV values were compared by a paired t-test.
  
  
  RESULTS
  The summed ESAS scores were significantly lower after the relaxation program (P<.01), with an average 31% decrease in total score. However, no differences were found in HRV HF power. There was no correlation between the change in HRV HF and change in symptom distress, as measured by ESAS.
  
  
  CONCLUSIONS
  A brief guided relaxation program can significantly improve symptoms as measured by ESAS. More research is required to understand the effects of relaxation on HF HRV power.
authors.affiliation: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, C-2000, Los Angeles, CA 90048, USA. arash.asher@cshs.org
authors.forename: Arash
authors.initials: A
authors.lastname: Asher
authors.forename: J Lynn
authors.initials: JL
authors.lastname: Palmer
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Yadav
authors.forename: Syed W
authors.initials: SW
authors.lastname: Yusuf
authors.forename: Benedict
authors.initials: B
authors.lastname: Konzen
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bruera
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology* / Q000523:psychology*; D010865:Pilot Projects; D012064:Relaxation Therapy; D012815:Signal Processing, Computer-Assisted; D013315:Stress, Psychological / Q000517:prevention & control