Immunoneutralization of procalcitonin or its component peptides: a promising treatment of sepsis.
Sepsis and the severe systemic response syndrome are very common illnesses that are responsible for a great amount of morbidity and death. These closely related conditions are characterized by a remarkable increase in the prohormone ProCT (procalcitonin). ProCT is both a marker of sepsis and a harmful mediator of the disease. In the present issue of Clinical Science, in a study in rats with endotoxin shock, Tavares and Miñano used an antibody to a segment of N-ProCT (aminoprocalcitonin) that is part of the ProCT molecule, and confirmed that immunoneutralization of ProCT saves the animals from this severe illness. Furthermore, they extensively studied the epiphenomena associated with this immunoneutralization.
Becker
Kenneth L
KL
George Washington University and Veterans Affairs Medical Center, Washington, DC 20037, USA. drkbecker@gmail.com
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood / Q000276:immunology*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D011498:Protein Precursors / Q000097:blood / Q000276:immunology*; D051381:Rats; D018805:Sepsis / Q000097:blood / Q000628:therapy*
D015415:Biomarkers; C000606589:CALCA protein, human; C000606591:Calca protein, rat; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide