title: [Analysis on the risk factors of intracardial thrombus after prosthetic valve replacement: a 1-year follow-up study].
abstract: OBJECTIVE
  To analysis the risk factors predicting intracardial thrombus after prosthetic valve replacement.
  
  
  METHODS
  The clinical data of 29 cases from January 2005 to April 2009 with intracardial thrombus after prosthetic valve replacement during a 1-year follow-up was retrospectively analyzed. There were 11 male and 18 female, aged from 12 to 70 years with a mean of 48 years. The risk factors of intracardial thrombus were examined by univariate and multivariate analysis.
  
  
  RESULTS
  Univariate analysis found that bioprosthetic valve replacement, anticoagulation using aspirin, valve replacement at mitral position, atrial fibrillation, preoperative and postoperative internal diameter of left atrium, postoperative fibrinogen were predict factors of intracardial thrombus after prosthetic valve replacement (P < 0.05). Logistic regression analysis showed valve replacement at mitral position (OR = 9.815, P < 0.05), atrial fibrillation (OR = 5.267, P < 0.05), preoperative internal diameter of left atrium (OR = 4.529, P < 0.05) were significant risk factors of intracardial thrombus after prosthetic valve replacement.
  
  
  CONCLUSIONS
  Valve replacement at mitral position, atrial fibrillation, and preoperative internal diameter of left atrium are the correlated risk factors of intracardial thrombus after prosthetic valve replacement. Anticoagulation after prosthetic valve (especially bioprosthetic valve) replacement should be standardized to prevent intracardial thrombus formation.
authors.affiliation: Department of Cardiovascular Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Ming-yan
authors.initials: MY
authors.lastname: Wang
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Gao
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Bo-jun
authors.initials: BJ
authors.lastname: Li
authors.forename: Sheng-li
authors.initials: SL
authors.lastname: Jiang
authors.forename: Chong-lei
authors.initials: CL
authors.lastname: Ren
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000209:etiology*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology*; D055815:Young Adult