Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome.
In infertile women suffering from polycystic ovary syndrome (PCOS), anti-thyroid peroxidase antibodies values exceeding the upper level of normal were found in significantly more clomiphene citrate resistant patients compared clomiphene citrate responders and metformin responders. Thus, elevated antiTPO levels are associated with poor treatment response in infertile women who suffer from PCOS.
Ott
Johannes
J
Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.
Aust
Stefanie
S
Kurz
Christine
C
Nouri
Kazem
K
Wirth
Stefan
S
Huber
Johannes C
JC
Mayerhofer
Klaus
K
D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D054316:Biomarkers, Pharmacological / Q000097:blood; D002996:Clomiphene / Q000627:therapeutic use*; D004351:Drug Resistance / Q000276:immunology; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro / Q000379:methods; D050031:Hashimoto Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007453:Iodide Peroxidase / Q000276:immunology*; D033862:Iron-Binding Proteins / Q000276:immunology*; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000276:immunology; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
D001323:Autoantibodies; D001324:Autoantigens; D054316:Biomarkers, Pharmacological; D005300:Fertility Agents, Female; D033862:Iron-Binding Proteins; D002996:Clomiphene; C056658:TPO protein, human; D007453:Iodide Peroxidase