title: Prevalence of distal diabetic polyneuropathy using quantitative sensory methods in a population with diabetes of more than 10 years' disease duration.
abstract: OBJECTIVE
  Results of studies on the prevalence of distal diabetic polyneuropathy (DPN) are contradictory. Conventional methods used for the diagnosis of DPN in clinical practice have limited effectiveness. The present study aimed to assess the prevalence of DPN in a population with long-standing diabetes (more than 10 years disease duration) by measuring vibratory, thermal and tactile sensitivities with quantitative sensory devices, as well as their relationship with associated clinical risk factors.
  
  
  METHODS
  A total of 1011 diabetic patients were evaluated in a multicenter, cross-sectional, observational study. The three sensitivities were assessed by ultrabiothesiometer, aesthesiometer and thermoskin devices, respectively. The prevalence of neuropathic pain was validated by the DN4 questionnaire.
  
  
  RESULTS
  Of the 1011 cases included, 400 (39.6%) met the diagnostic criteria of DPN, while no DPN was found in the remaining 611 (60.4%). Of the 400 patients with DPN, 253 (63.2%) showed clinical manifestations, while 147 (36.8%) were diagnosed as subclinical DPN. The prevalence of DPN increased with disease duration. There was a progressive loss of the three sensitivities with increased disease duration, particularly thermal and vibratory sensitivities. This loss was statistically significant for the latter two sensitivities. Among patients with clinical DPN, 84.2% had painful neuropathic symptoms. The prevalence of DPN was positively related to micro- and macroangiopathic complications and with dyslipidemia.
  
  
  CONCLUSIONS
  This study reveals a high degree of underdiagnosis of DPN, most likely due to the asymptomatic nature of the disease in a considerable proportion of patients. Our observations provide evidence of the usefulness of specific equipment for quantitative and objective assessment of polyneuropathy.
authors.affiliation: Hospital Clínico Universitario, Salamanca, Spain. miralles@usal.es
authors.forename: José M
authors.initials: JM
authors.lastname: Miralles-García
authors.forename: Pedro
authors.initials: P
authors.lastname: de Pablos-Velasco
authors.forename: Lucio
authors.initials: L
authors.lastname: Cabrerizo
authors.forename: María
authors.initials: M
authors.lastname: Pérez
authors.forename: Vanessa
authors.initials: V
authors.lastname: López-Gómez
mesh_terms: D003430:Cross-Sectional Studies; D003929:Diabetic Neuropathies / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012677:Sensation; D013997:Time Factors