title: Pregestational body mass index, weight gain during pregnancy and maternal hyperglycemia.
abstract: OBJECTIVE
  To evaluate the associations between pregestational BMI and weight gain during pregnancy and the risk for maternal hyperglycemia.
  
  
  METHODS
  The charts of all patients who delivered at our hospital between June 2001 and June 2006 were reviewed. Maternal hyperglycemia categories were defined as GDM (by the Carpenter and Coustan criteria); Impaired glucose tolerance (IGT - only one abnormal value in the 100 g OGTT); Abnormal GCT (≥140 mg/dL) but no high values on the OGTT. Women with GCT < 140 were defined as normal glucose tolerance (NGT).
  
  
  RESULTS
  Pregravid BMI and glucose tolerance data were available for 9269 women. We also had data on weight gain during pregnancy for 7766 of these women. There was strong graded association between increasing BMI category and all levels of maternal hyperglycemia. There was significant negative correlation between BMI and weight gain during pregnancy (R = -0.251, P value < 0.0001). However, in the multivariate logistic regression model, only pregestational BMI was significantly associated with maternal hyperglycemia, whereas weight gain during pregnancy was no longer significant.
  
  
  CONCLUSIONS
  Obesity is a strong predictor for gestational maternal hyperglycemia. Weight gain during pregnancy has less effect. Every effort should be made for pregestational weight reduction in overweight women.
authors.affiliation: Rappaport Faculty of Medicine, Departement of Obstetrics and Gynecology, The Lady Davis Carmel Medical Center, Technion, Haifa, Israel. shlomitriskin@gmail.com
authors.forename: Shlomit
authors.initials: S
authors.lastname: Riskin-Mashiah
authors.forename: Amit
authors.initials: A
authors.lastname: Damti
authors.forename: Grace
authors.initials: G
authors.lastname: Younes
authors.forename: Ron
authors.initials: R
authors.lastname: Auslander
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology*; D015430:Weight Gain / Q000502:physiology*
chemical_list: D001786:Blood Glucose