[Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance].
OBJECTIVE
To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.


METHODS
PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.


RESULTS
PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).


CONCLUSIONS
Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.
Tang
Ming-hua
MH
Department of Urology, Zhenjiang First People's Hospital, Zhenjiang 212002, China. huamingt@126.com
Tan
Jian
J
Cui
Fei-lun
FL
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D064249:Securin
D009363:Neoplasm Proteins; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human