Anti-trypanosomal activity of (8-hydroxymethylen)-trieicosanyl acetate against infective forms of Trypanosoma cruzi.
The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Reduced parasitemia levels of 70.5%, 73.8%, and 80.9%, respectively, were observed. A significant reduction in amastigote nests was detected in the cardiac tissue of treated animals at doses of 8.4 and 33.6 microg/g. The LD50 of (8-hydroxymethylen)-trieicosanyl acetate was impossible to determine because none of the animals died, even at oral doses of 5000 microg/g; consequently, it was impossible to determine the acute oral toxicity in vivo.
Jimenez-Coello
Matilde
M
Laboratorio de Biologia Celular, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico.
Acosta-Viana
Karla Y
KY
Guzman-Marin
Eugenia
E
Perez Gonzalez
Cuahutemoc
C
Salud Perez Gutierrez
Maria
M
D000085:Acetates / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004305:Dose-Response Relationship, Drug; D015777:Eicosanoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D007887:Fabaceae / Q000737:chemistry; D006321:Heart / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D023382:Toxicity Tests, Acute; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D014349:Trypanosoma cruzi / Q000187:drug effects*
C534089:(8-hydroxymethylen)trieicosanyl acetate; D000085:Acetates; D015777:Eicosanoids; D010936:Plant Extracts; D014344:Trypanocidal Agents