title: Antiproliferative diterpenoids from the leaves of Isodon rubescens.
abstract: A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E ( 1- 5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Li Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Xiao Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Chen
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts