title: 22q11.2 deletion syndrome: are motor deficits more than expected for IQ level?
abstract: OBJECTIVE
  To examine motor function in children with 22q11.2 deletion syndrome (22q11.2) and a Full Scale IQ (FSIQ) comparable control group.
  
  
  METHODS
  This study was part of a prospective study of neuropsychological function in children 9 to 15 years of age with 22q11.2 and community control subjects and included children from these two populations with comparable FSIQs.
  
  
  RESULTS
  Verbal IQs on the WISC-R for 40 children with 22q11.2 (88.4) and 24 community control subjects (87.2) were not different (P=.563). However, the performance IQs were (22q11.2; 81.1 vs community controls; 89.3; P<.001). On the Visual Motor Inventory, there was no difference between the standard scores of the two groups (22q11.2; 93.0 vs community control subjects; 98.1; P=.336) but on the motor coordination part of the Visual Motor Inventory, the scores of the 22q11.2 deletion syndrome group were lower (77.2 vs 89.3; P=.002). On the general neurologic examination (P=.906), the tone examination (P=.705), and the ball skills part of the Motor Battery, (P=.378), there were no differences. However, on the axial stability part of the Motor Battery, the children with 22q11.2 exhibited less good balance (P=.026).
  
  
  CONCLUSIONS
  School-aged children with 22q11.2 have specific motor deficits in axial stability and graphomotor skills.
authors.affiliation: Department of Psychiatry & Behavioral Sciences, the Center for the Diagnosis, Treatment, and Study of Velo-Cardio-Facial Syndrome and the Communications Disorder Unit, State University of New York-Upstate Medical University, Syracuse, NY, USA. nancy.roizen@uhhospitals.org
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Roizen
authors.forename: Anne M
authors.initials: AM
authors.lastname: Higgins
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Antshel
authors.forename: Wanda
authors.initials: W
authors.lastname: Fremont
authors.forename: Robert
authors.initials: R
authors.lastname: Shprintzen
authors.forename: Wendy R
authors.initials: WR
authors.lastname: Kates
mesh_terms: D002648:Child; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D019957:Motor Skills Disorders / Q000453:epidemiology* / Q000235:genetics*; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires