title: Neurotoxocariasis associated with lower motor neuron disease. Report of one case.
abstract: We report a 51-year-old male with a history of palpitations, hepatopathy and hypercholesterolemia, who habitually ate raw goat meat, and developed general fasciculations, muscle cramps in the lower limbs, distal muscle weakness and wasting, without upper motor neuron signs or sensory abnormalities. Diagnostic workup revealed positive antibodies against Toxocara canis in the serum and cerebrospinal fluid. Nerve conduction studies revealed a proximal and distal axonal lesion of motor nerves and needle electromyography was indicative of acute and chronic denervation with giant motor unit action potentials. Despite a therapy with albendazole and riluzole, muscle weakness and wasting further progressed and affected also the respiratory muscles. Followup nerve conduction studies and electromyography confirmed progression of the axonal degeneration. Whether lower motor neuron disease was causally related to neurotoxocariasis or due to a general metabolic defect, remains speculative.
authors.affiliation: Neurological Department, Krankenanstalt Rudolfstiftung, Vienna, Austria. fifigs1@yahoo.de
authors.forename: Josef
authors.initials: J
authors.lastname: Finsterer
authors.forename: Verena
authors.initials: V
authors.lastname: Kallab
authors.forename: Herbert
authors.initials: H
authors.lastname: Auer
mesh_terms: D000818:Animals; D020809:Central Nervous System Helminthiasis / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000469:parasitology*; D017227:Toxascariasis / Q000150:complications*; D017166:Toxocara canis / Q000276:immunology / Q000302:isolation & purification