Fragment-based discovery and optimization of BACE1 inhibitors.
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.
Madden
James
J
Evotec UK Ltd, Abingdon, UK. james.madden@evotec.com
Dod
Jenny R
JR
Godemann
Robert
R
Kraemer
Joachim
J
Smith
Myron
M
Biniszkiewicz
Marion
M
Hallett
David J
DJ
Barker
John
J
Dyekjaer
Jane D
JD
Hesterkamp
Thomas
T
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D006801:Humans; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human