Multifunctional agents for concurrent imaging and therapy in cardiovascular disease.
The development of agents for the simultaneous detection and treatment of disease has recently gained significant attention. These multifunctional theranostic agents posses a number of advantages over their monofunctional counterparts, as they potentially allow for the concomitant determination of agent localization, release, and efficacy. Whereas the development of these agents for use in cancers has received the majority of the attention, their use in cardiovascular disease is steadily increasing. As such, this review summarized some of the most poignant recent advances in the development of theranostic agents for the treatment of this class of diseases.
McCarthy
Jason R
JR
Center for Systems Biology, Harvard Medical School, Massachusetts General Hospital, Charlestown, 02129, USA. jason_mccarthy@hms.harvard.edu
D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D003952:Diagnostic Imaging / Q000379:methods*; D004337:Drug Carriers / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use
D004337:Drug Carriers