title: Anaplastic sarcoma of the kidney with chromosomal abnormality: first report on cytogenetic findings.
abstract: We report a case of anaplastic sarcoma of the kidney (ASK) with cytogenetic findings. A 12-year-old Japanese girl presented with buttock pain and urinary incontinence. Radiological investigations revealed a right renal tumor with multiple distant metastases and multicystic thyroid tumor. She underwent radical right nephrectomy and subsequently received chemotherapy and radiation therapy. Histologically, the renal tumor demonstrated admixture of various types of mesenchymal elements: cellular spindle cells with anaplastic features, cartilage, and rhabdomyoblastic cells consistent with ASK. Chromosomal analysis revealed the karyotype of the tumor cells to be 46, XX, +8, -10, der (18) t (10; 18) (q21; p11.2). The thyroid tumor was removed later and diagnosed as adenomatous goiter. To our knowledge, this is the first case of ASK with chromosomal abnormality and may provide new insight into the molecular biologic basis of this rare renal tumor.
authors.affiliation: Division of Pathology, Kanagawa Children's Medical Center, Yokohama City, Kanagawa, Japan. gomikiyoshi@yahoo.co.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Gomi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hamanoue
authors.forename: Mio
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masae
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Tetsu
authors.initials: T
authors.lastname: Niwa
authors.forename: Noriko
authors.initials: N
authors.lastname: Aida
authors.forename: Hisato
authors.initials: H
authors.lastname: Kigasawa
authors.forename: Yukichi
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006042:Goiter / Q000235:genetics / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D012509:Sarcoma / Q000235:genetics / Q000556:secondary*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology