Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats.
Chronic social defeat stress, a depression model in rats, reduced struggling in the forced swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled less. Social defeat reduced brain regional energy metabolism, and this effect was also more pronounced in rats with high sucrose intake. A number of changes in gene expression were identified after social defeat stress, most notably the down-regulation of Gsk3b and Map1b. The majority of differences were between stress-susceptible and resilient rats. Conclusively, correlates of inter-individual differences in stress resilience can be identified both at gene expression and oxidative metabolism levels.
Kanarik
Margus
M
Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia.
Alttoa
Aet
A
Matrov
Denis
D
Kõiv
Kadri
K
Sharp
Trevor
T
Panksepp
Jaak
J
Harro
Jaanus
J
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D003863:Depression / Q000235:genetics / Q000378:metabolism*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology; D004734:Energy Metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling; D046228:Microarray Analysis; D051381:Rats; D017208:Rats, Wistar; D055500:Resilience, Psychological; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism*; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013550:Swimming
D018491:Dopamine Agonists; D013549:Sweetening Agents; D013395:Sucrose; D001058:Apomorphine