title: Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.
abstract: This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Xiao Jia
authors.initials: XJ
authors.lastname: Yin
authors.forename: Guan Hong
authors.initials: GH
authors.lastname: Xu
authors.forename: Xu
authors.initials: X
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.forename: Xing
authors.initials: X
authors.lastname: Ji
authors.forename: Ke
authors.initials: K
authors.lastname: Jiang
authors.forename: Fei
authors.initials: F
authors.lastname: Li
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry*; D010226:Parabens / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D009570:Nitriles; D010226:Parabens; D011804:Quinolines; C471992:bosutinib; C038193:4-hydroxybenzoic acid