Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives.
In an effort to improve potential hepatoprotective and anti-tumor activities, eight novel ursolic acid (UA) derivatives were designed and synthesized with substitution at positions of C-3, C-11 and C-28 of UA. Their structures were confirmed using IR, MS and (1)H-NMR and elemental analysis. Their in vitro cytotoxicity against various cancer cell lines (HeLa, SKOV3 and BGC-823) was evaluated by the standard MTT assay. Among them, compound 13 exhibited more potent cytotoxicity than ursolic acid.
Meng
Yanqiu
Y
Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Iiaoning 110042, China. mengyanqiu@hotmail.com
Song
Yanling
Y
Yan
Zhaokai
Z
Xia
Yan
Y
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000097245:Ursolic Acid
D014315:Triterpenes; D000097245:Ursolic Acid