title: Evaluation of antirotavirus activity of flavonoids.
abstract: Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure-activity relationships (SAR) were proposed based on antirotavirus activity.
authors.affiliation: Laboratório de Virologia Aplicada, Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC 88.040-970, Brazil.
authors.forename: Luciane Anita
authors.initials: LA
authors.lastname: Savi
authors.forename: Thiago
authors.initials: T
authors.lastname: Caon
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: de Oliveira
authors.forename: Andrea Michel
authors.initials: AM
authors.lastname: Sobottka
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Werner
authors.forename: Flávio Henrique
authors.initials: FH
authors.lastname: Reginatto
authors.forename: Eloir Paulo
authors.initials: EP
authors.lastname: Schenkel
authors.forename: Célia Regina Monte
authors.initials: CR
authors.lastname: Barardi
authors.forename: Cláudia Maria Oliveira
authors.initials: CM
authors.lastname: Simões
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D012401:Rotavirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids