Focal sensory-motor status epilepticus in multiple sclerosis due to a new cortical lesion. An EEG-fMRI co-registration study.
A case of focal inferior limb sensory-motor status epilepticus as the only manifestation of a multiple sclerosis (MS) relapse is described. To obtain evidence of the relationship between the seizures, the cortical plaque and the left foot motor area, an EEG-fMRI co-registration study was undertaken demonstrating that seizure-related BOLD signal substantially overlapped with the inflammatory lesion involving the foot sensory-motor cortex. Seizures did not respond to intravenous anti-epileptic drugs (AEDs) but were controlled by steroid therapy.
Gasparini
Elisa
E
Department of Neuroscience, Nuovo Ospedale Civile S.Agostino-Estense, University of Modena and Reggio Emilia, Via Giardini, 41100 Modena, Italy.
Benuzzi
Francesca
F
Pugnaghi
Matteo
M
Ariatti
Alessandra
A
Sola
Patrizia
P
Nichelli
Paolo
P
Meletti
Stefano
S
D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D011984:Sensory Receptor Cells / Q000473:pathology / Q000502:physiology; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids