title: Highly efficient route to functionalized tetrahydrocarbazoles using a tandem cross-metathesis/intramolecular-hydroarylation sequence.
abstract: The scope of the novel ruthenium-catalyzed tandem cross-metathesis/intramolecular-hydroarylation sequence is described. This methodology offers a practical and efficient synthesis of structurally diverse and complex tetrahydrocarbazoles in good to excellent yields (up to 98%). Moreover, preliminary efforts towards the development of an enantioselective version of the current process by sequential catalysis with ruthenium complex and chiral amine are presented, with high yields and enantioselectivities (up to 88% yield and 91% ee).
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: An
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Li
authors.forename: Fu-Gen
authors.initials: FG
authors.lastname: Zhang
authors.forename: You-Quan
authors.initials: YQ
authors.lastname: Zou
authors.forename: Ying-Cen
authors.initials: YC
authors.lastname: Guo
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000588:Amines / Q000737:chemistry; D002227:Carbazoles / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D002227:Carbazoles; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D012428:Ruthenium