title: A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.
abstract: B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.
authors.affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Ligocki
authors.forename: L
authors.initials: L
authors.lastname: Lovato
authors.forename: D
authors.initials: D
authors.lastname: Xiang
authors.forename: P
authors.initials: P
authors.lastname: Guidry
authors.forename: R H
authors.initials: RH
authors.lastname: Scheuermann
authors.forename: S N
authors.initials: SN
authors.lastname: Willis
authors.forename: S
authors.initials: S
authors.lastname: Almendinger
authors.forename: M K
authors.initials: MK
authors.lastname: Racke
authors.forename: E M
authors.initials: EM
authors.lastname: Frohman
authors.forename: D A
authors.initials: DA
authors.lastname: Hafler
authors.forename: K C
authors.initials: KC
authors.lastname: O'Connor
authors.forename: N L
authors.initials: NL
authors.lastname: Monson
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*
chemical_list: D000906:Antibodies; D011947:Receptors, Antigen, B-Cell