title: [Is there a relationship between leptin and the phenotype of gastroesophageal reflux disease?].
abstract: OBJECTIVE
  Obesity is associated with gastroesophageal reflux disease (GERD). Leptin is a hormone which controls appetite and energy homeostasis. Alterations of its level in humans have been linked with obesity and related carcinogenesis. We postulated that the leptin level in plasma or tissues might be different according to the phenotype of GERD. We evaluated this hormone in patients with non-erosive reflux disease (NERD) and reflux esophagitis (RE) with demographic characteristics to confirm the postulation.
  
  
  METHODS
  The patients with typical GERD symptoms such as acid regurgitation and heartburn were prospectively enrolled and evaluated. The demographic data included body mass index, waist circumference, smoking, and the consumption of coffee. Rapid urease test was done to evaluate the status of Helicobacter pylori infection. We measured plasma leptin level along with the tissue level, which was obtained from the fundus of stomach.
  
  
  RESULTS
  A total of 44 patients were evaluated (RE 20 cases, NERD 24 cases). No demographic data was different between the two groups, except waist circumference (mean 88.6 cm in RE, 80.9 cm in NERD, p=0.006), smoking (45% in RE, 12.5% in NERD, p=0.021) and coffee consumption (85% in RE, 50% in NERD, p=0.025). The level of plasma leptin was not different between the two groups. The level of tissue leptin was also not different between the two groups with an increasing tendency in RE (mean 32.5 ng/mL vs. 28.0 ng/mL in NERD).
  
  
  CONCLUSIONS
  We could not find any association between plasma and tissue leptin levels and the phenotype of GERD. However, increasing tendency in RE could afford to further studies in near future.
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Seong Woo
authors.initials: SW
authors.lastname: Jeon
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Jung
authors.forename: Myung Hoon
authors.initials: MH
authors.lastname: Lee
authors.forename: Joong Goo
authors.initials: JG
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003069:Coffee; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D020738:Leptin / Q000032:analysis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010641:Phenotype; D012907:Smoking; D055105:Waist Circumference
chemical_list: D003069:Coffee; D020738:Leptin