Stem cell labeling for noninvasive delivery and tracking in cardiovascular regenerative therapy.
Clinical and basic scientific studies of stem cell-based therapies have shown promising results for cardiovascular diseases. Despite a rapid transition from animal studies to clinical trials, the mechanisms by which stem cells improve heart function are yet to be fully elucidated. To optimize cell therapies in patients will require a noninvasive means to evaluate cell survival, biodistribution and fate in the same subject over time. Cell labeling offers the ability to image distinct cell lineages in vivo and investigate the efficacy of these therapies using standard noninvasive imaging techniques. In this article, we will discuss the most promising cell labeling techniques for translation to clinical cardiovascular applications.
Fu
Yingli
Y
The Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, 600 N. Wolfe Street, 314 Park Building, Baltimore, MD 21287, USA.
Kraitchman
Dara L
DL
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy*; D002470:Cell Survival; D003287:Contrast Media / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D011877:Radionuclide Imaging; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000000981:diagnostic imaging*; D014018:Tissue Distribution
D003287:Contrast Media