title: Synthesis and antituberculosis activity of new fatty acid amides.
abstract: This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 microg/mL for resistance strains.
authors.affiliation: Laboratório Kolbe de Síntese Orgânica, Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
authors.forename: Caroline Da Ros Montes
authors.initials: Cda R
authors.lastname: D'Oca
authors.forename: Tatiane
authors.initials: T
authors.lastname: Coelho
authors.forename: Tamara Germani
authors.initials: TG
authors.lastname: Marinho
authors.forename: Carolina Rosa Lopes
authors.initials: CR
authors.lastname: Hack
authors.forename: Rodrigo da Costa
authors.initials: Rda C
authors.lastname: Duarte
authors.forename: Pedro Almeida
authors.initials: PA
authors.lastname: da Silva
authors.forename: Marcelo Gonçalves Montes
authors.initials: MG
authors.lastname: D'Oca
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis*; D005227:Fatty Acids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000577:Amides; D000995:Antitubercular Agents; D005227:Fatty Acids