title: Effect of early achievement of physiologic resuscitation goals in septic patients admitted from the ward on the kidneys.
abstract: OBJECTIVE
  The aim of the study was to evaluate if early achievement of physiologic goals of resuscitation in critically ill septic patients admitted from the ward may prevent acute kidney injury (AKI).
  
  
  METHODS
  Patients admitted to the intensive care unit (ICU) with a diagnosis of sepsis were retrospectively identified. Mean arterial pressure greater than 65 mm Hg, central venous pressure greater than 8 mm Hg, and central venous oxygenation greater than 70% achieved within 6 hours after ICU consultation at the ward was considered early achievement. Acute kidney injury was defined by the RIFLE criteria.
  
  
  RESULTS
  Of 85 patients, 29% achieved all goals within 6 hours, 42% had late or no achievement of goals, and 28% had incomplete documentation of goals. Of these, 52% developed AKI. Patients who eventually developed AKI had a significantly higher creatinine level at ICU consultation before resuscitation. Delay in achievement of goals results in a 3.4% creatinine level rise per hour in multivariate analysis (P = .03). The development of AKI was significantly influenced by delayed achievement of physiologic goals on the ICU (P = .02).
  
  
  CONCLUSIONS
  Although most of AKI occurred before ICU consultation, early physiologic resuscitation and achievement of hemodynamic goals on the ICU is associated with a decrease in development of AKI of septic patients admitted from the ward.
authors.affiliation: Department of Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.
authors.forename: H D
authors.initials: HD
authors.lastname: Kiers
authors.forename: Donald E G
authors.initials: DE
authors.lastname: Griesdale
authors.forename: Andrea
authors.initials: A
authors.lastname: Litchfield
authors.forename: Steven
authors.initials: S
authors.lastname: Reynolds
authors.forename: R T N
authors.initials: RT
authors.lastname: Gibney
authors.forename: Dean
authors.initials: D
authors.lastname: Chittock
authors.forename: Peter
authors.initials: P
authors.lastname: Pickkers
authors.forename: David D
authors.initials: DD
authors.lastname: Sweet
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000517:prevention & control; D000368:Aged; D016638:Critical Illness; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012151:Resuscitation; D012189:Retrospective Studies; D012306:Risk; D018805:Sepsis / Q000150:complications* / Q000628:therapy*; D012772:Shock, Septic / Q000150:complications / Q000628:therapy; D013997:Time Factors