title: Histologic evaluation of recombinant human platelet-derived growth factor-BB after use in extraction socket defects: a case series.
abstract: Recent advancements in the arena of therapeutic molecular enhancement have shown favorable clinical findings for periodontics. However, further studies to optimize clinical outcomes using this technology are warranted. Twelve premolar extraction sockets were assigned randomly for treatment with 0.3 mg/mL recombinant human platelet-derived growth factor (rhPDGF-BB) combined with either a collagen containing anorganic deproteinized bovine bone (xenograft) or beta-tricalcium phosphate (b-TCP). Histologic evaluation of extraction socket healing was performed at 3 months. Histologic findings were similar with b-TCP and the xenograft, having 21% and 24% vital bone, respectively. The use of rhPDGF-BB with either b-TCP or a xenograft resulted in uneventful socket healing. At reentry, all implants were placed without the need for further grafting, and 100% implant success was recorded at the time of final evaluation (restoration completion).
authors.affiliation: Department of Periodontology, Oregon Health and Science University, Portland, Oregon, USA. mcallister@portlandimplantdentistry.com
authors.forename: Bradley S
authors.initials: BS
authors.lastname: McAllister
authors.forename: Kamran
authors.initials: K
authors.lastname: Haghighat
authors.forename: Hari S
authors.initials: HS
authors.lastname: Prasad
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rohrer
mesh_terms: D000328:Adult; D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D000077214:Becaplermin; D001641:Bicuspid / Q000601:surgery; D001672:Biocompatible Materials / Q000627:therapeutic use; D001706:Biopsy; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use; D003238:Connective Tissue / Q000637:transplantation; D015921:Dental Implants; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D014183:Transplantation, Heterologous; D014945:Wound Healing / Q000502:physiology
chemical_list: D043925:Angiogenesis Inducing Agents; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D008903:Minerals; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; C485817:beta-tricalcium phosphate; D000077214:Becaplermin; D003094:Collagen