title: Estimating the risk of HIV transmission from homosexual men receiving treatment to their HIV-uninfected partners.
abstract: OBJECTIVE
  To determine how the risk of HIV transmission from homosexual men receiving antiretroviral treatment is related to patterns of patient monitoring and condom use.
  
  
  METHODS
  A stochastic mathematical simulation model was developed of cohorts of men in the Netherlands who have sex with men (MSM), defining the parameters of the model using observational cohort data. The model incorporates viral load trends during first-line treatment, patient monitoring and different scenarios for the way in which condom use may depend on recent viral load measurements. The model does not include the effect of sexually transmitted infections on HIV transmission.
  
  
  RESULTS
  For MSM receiving treatment, the risk of transmitting HIV to their long-term partner is 22% (uncertainty interval: 9-37%) if condoms are never used. With incomplete use (in 30% of sex acts) the risk is reduced slightly, to 17% (7-29%). However, the risk is as low as 3% (0.2-8%) when men receiving treatment use condoms only 6 months beyond their last undetectable viral load measurement. The risk is further reduced when 3 months is the time period beyond which condoms are used.
  
  
  CONCLUSIONS
  When condom use by HIV-infected men receiving combination treatment with antiretroviral agents is based on their last viral load measurement, the transmission risk is much lower than with incomplete condom use. The key message for patients is that although always using condoms during treatment is the best way to protect partners from the risk of HIV transmission, when such use cannot be achieved, the second best strategy is to use condoms whenever the last undetectable viral load was measured more than 3 months ago.
authors.affiliation: Department of Infectious Disease Epidemiology, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK. timothy.hallett@imperial.ac.uk
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Hallett
authors.forename: Colette
authors.initials: C
authors.lastname: Smit
authors.forename: Geoff P
authors.initials: GP
authors.lastname: Garnett
authors.forename: Frank
authors.initials: F
authors.lastname: de Wolf
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D017280:Condoms / Q000706:statistics & numerical data; D004812:Epidemiologic Methods; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D012747:Sexual Partners; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents