title: Association of serum IGF1 with endothelial function: results from the population-based study of health in Pomerania.
abstract: OBJECTIVE
  IGF1 mediates multiple physiological and pathophysiological responses in the cardiovascular system. The aim of this study was to analyze the association between serum IGF1 as well as IGF-binding protein 3 (IGFBP3) levels and endothelial function measured by flow-mediated dilation (FMD).
  
  
  METHODS
  Cross-sectional population-based observational study.
  
  
  METHODS
  The study population comprised 1482 subjects (736 women) aged 25-85 years from the Study of Health in Pomerania. Serum IGF1 and IGFBP3 levels were determined by chemiluminescence immunoassays. FMD measurements were performed using standardized ultrasound techniques. FMD values below the sex-specific median were considered low.
  
  
  RESULTS
  In males, logistic regression analyses revealed an odds ratio (OR) of 1.27 (95% confidence interval (CI) 1.07-1.51; P=0.008) for decreased FMD for each decrement of IGF1 s.d. after adjustment for major cardiovascular confounders. In females, no significant relationship between serum IGF1 and FMD was found (OR 0.88, CI 0.74-1.05; P=0.147). After exclusion of subjects with the current use of antihypertensive medication, these findings were similar (males: OR 1.40, CI 1.12-1.75; P=0.003; females: OR 0.95, CI 0.77-1.16; P=0.595). There was no association between serum IGFBP3 levels and FMD in both sexes.
  
  
  CONCLUSIONS
  Low serum IGF1 levels are associated with impaired endothelial function in males. In women, serum IGF1 is not associated with endothelial function.
authors.affiliation: Department of Cardiology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. empen@uni-greifswald.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Empen
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorbeer
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Robinson
authors.forename: Nele
authors.initials: N
authors.lastname: Friedrich
authors.forename: Alexander
authors.initials: A
authors.lastname: Krebs
authors.forename: Matthias
authors.initials: M
authors.lastname: Nauck
authors.forename: Thorsten
authors.initials: T
authors.lastname: Reffelmann
authors.forename: Ralf
authors.initials: R
authors.lastname: Ewert
authors.forename: Stephan B
authors.initials: SB
authors.lastname: Felix
authors.forename: Henri
authors.initials: H
authors.lastname: Wallaschofski
authors.forename: Marcus
authors.initials: M
authors.lastname: Dörr
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004727:Endothelium / Q000502:physiology*; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012737:Sex Factors; D014664:Vasodilation / Q000502:physiology
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I