title: Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma.
abstract: BACKGROUND
  Curcumin is one of the most studied natural compounds which has been used as a feed additive for centuries. Curcumin exhibits low oral bioavailability in rodents and human. Curcumin formulated with phosphatidylcholine (Meriva) increases curcumin bioavailability five-fold compared to original curcumin. The aim of this study was to evaluate the efficacy of curcumin conjugated with phosphatidylcholine as an anticancer agent.
  
  
  METHODS
  In this xenograft study, mammary gland tumor cell line (ENU1564) was inoculated into the mammary fat pad of athymic nude mice. The mice were treated orally with either curcumin or Meriva. The tumor and its lung metastasis were evaluated grossly, microscopically, and immunohistochemically.
  
  
  RESULTS
  Meriva significantly reduced the expression of MMP-9 and lung metastasis of our cell line used in this experimental model.
  
  
  CONCLUSIONS
  Curcumin conjugated with phosphatidylcholine increased the efficacy of curcumin as an anticancer agent.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
authors.forename: Abdelazim
authors.initials: A
authors.lastname: Ibrahim
authors.forename: Abdelmouneim
authors.initials: A
authors.lastname: El-Meligy
authors.forename: Hamdy
authors.initials: H
authors.lastname: Fetaih
authors.forename: Amina
authors.initials: A
authors.lastname: Dessouki
authors.forename: George
authors.initials: G
authors.lastname: Stoica
authors.forename: Rola
authors.initials: R
authors.lastname: Barhoumi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D009336:Necrosis; D009368:Neoplasm Transplantation / Q000379:methods; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D010713:Phosphatidylcholines; D003474:Curcumin