title: [Involvement of natural regulatory lymphocytes in allograft tolerance].
abstract: Naturally occurring regulatory T-cells (Tregs) play a critical role in the homeostasis of healthy immune system. A Treg deficiency is responsible for immune system dysregulation, immune hyperreactivity and autoimmunity. Herein, we investigated the role of Tregs, either in the context of antibody-induced transplantation tolerance, mixed donor/recipient chimerism or in models of spontaneous graft acceptance without immunosuppression. We also investigated their capacities to control endotoxin-mediated immune response in the context of lymphopaenia-driven homeostatic T-cell proliferation. Finally, although Tregs adequately control Th1 and Th2 immunity, they are inefficient in regulating IL-17 producing T cells in vitro and in vivo and rather promote them.
authors.affiliation: Institut d'Immunologie médicale-U.L.B.
authors.forename: A
authors.initials: A
authors.lastname: Le Moine
authors.forename: F S
authors.initials: FS
authors.lastname: Benghaiat
authors.forename: V
authors.initials: V
authors.lastname: De Wilde
authors.forename: B
authors.initials: B
authors.lastname: Vokaer
authors.forename: L M
authors.initials: LM
authors.lastname: Charbonnier
authors.forename: M
authors.initials: M
authors.lastname: Goldman
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018183:Transplantation Chimera / Q000276:immunology; D023001:Transplantation Tolerance / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*
chemical_list: D015703:Antigens, CD