title: A novel sulfated holostane glycoside from sea cucumber Holothuria leucospilota.
abstract: A new sulfated holostane glycoside, leucospilotaside B (1), together with the two related structurally known compounds holothurin B(2) (2) and holothurin B (3), was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea. The structure of 1 was elucidated by spectral analysis (1H-, 13C-, and 2D-NMR, ESI-MS, and HR-ESI-MS) and chemical methods. The compounds 1-3 possess the same disaccharide moiety, but were different in the side chains of the triterpene aglycone. Compound 1 showed significant cytotoxicities against four human tumor cell lines, HL-60, MOLT-4, A-549, and BEL-7402.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China. hhan05@126.com
authors.forename: Hua
authors.initials: H
authors.lastname: Han
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Bao-Shu
authors.initials: BS
authors.lastname: Liu
authors.forename: Min-Xiang
authors.initials: MX
authors.lastname: Pan
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D047332:Holothuria / Q000737:chemistry*; D006801:Humans; D013431:Sulfates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D013431:Sulfates; D014315:Triterpenes