Doxycycline failure in lymphogranuloma venereum.
Lymphogranuloma venereum (LGV) cases are currently re-emerging in the homosexual community, particularly in HIV-seropositive patients. The standard treatment for this infection, which is caused by Chlamydia trachomatis L1, L2 and L3 serotypes, is a 3-week doxycycline regimen. The case is reported of a male patient presenting with LGV, who was rapidly cured with moxifloxacin treatment after failure of extended treatment with cyclines. This fluoroquinolone is known to be highly active in vitro on the LGV pathogenic agent. Thus it may be a useful alternative when doxycycline treatment results in failure.
Méchaï
Frédéric
F
Service des Maladies Infectieuses et Tropicales, Hôpital d'Instruction des Armées Bégin, Saint Mandé 94160, France. mechaifrederic@wanadoo.fr
de Barbeyrac
Bertille
B
Aoun
Olivier
O
Mérens
Audrey
A
Imbert
Patrick
P
Rapp
Christophe
C
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use*; D024841:Fluoroquinolones; D018451:Homosexuality, Male; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000188:drug therapy*; D008297:Male; D000077266:Moxifloxacin; D011349:Proctitis / Q000382:microbiology; D011804:Quinolines / Q000627:therapeutic use*; D017211:Treatment Failure
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D004318:Doxycycline; D000077266:Moxifloxacin