Mitochondrial biogenesis related endurance genotype score and sports performance in athletes.
We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
Eynon
Nir
N
Genetics and Molecular Biology Laboratory, Life Sciences Division, The Zinman College of Physical Education and Sport Sciences at Wingate Institute, Israel. eynon@wincol.ac.il
Ruiz
Jonatan R
JR
Meckel
Yoav
Y
Morán
María
M
Lucia
Alejandro
A
D000328:Adult; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D047494:PPAR delta / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010807:Physical Endurance / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D013177:Sports; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D044465:White People / Q000235:genetics*; D055815:Young Adult
D006360:Heat-Shock Proteins; D047494:PPAR delta; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors