title: [Hydrogen magnetic resonance quantitative spectroscopy at 3 T in symptomatic and asymptomatic Huntington's disease patients].
abstract: BACKGROUND
  Huntington's disease is an hereditary autosomic-dominant neurodegenerative disorder, characterized by motor, cognitive and psychiatric symptoms.
  
  
  OBJECTIVE
  To quantify differences in N-acetylaspartate, creatine and choline in caudate nucleus, putamen and occipital cortex of patients with Huntington's disease, symptomatics and asymptomatics.
  
  
  METHODS
  Hydrogen magnetic resonance spectroscopy was performed with a 3 T scanner in 10 Huntington's disease gene-tested subjects, included in three groups: negative (control), positive symptomatics and positive asymptomatics. Data was quantified with LCModel and analyzed with ANOVA and Fisher tests.
  
  
  RESULTS
  Symptomatic patients showed decreased creatine and N-acetylaspartate in the three regions, and decreased choline only in putamen (p < 0.05). Choline difference was found between symptomatics and asymptomatics in the caudate nucleus (p < 0.05).
  
  
  CONCLUSIONS
  Results may reflect neuronal dysfunction and suggest that creatine and choline may serve as markers for Huntington's disease progression.
authors.affiliation: Posgrado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Querétaro, QRO, México.
authors.forename: Sarael
authors.initials: S
authors.lastname: Alcauter-Solórzano
authors.forename: Erick H
authors.initials: EH
authors.lastname: Pasaye-Alcaraz
authors.forename: Patricia
authors.initials: P
authors.lastname: Alvarado-Alanis
authors.forename: Rafael O
authors.initials: RO
authors.lastname: Fermín-Delgado
authors.forename: M Elisa
authors.initials: ME
authors.lastname: Alonso-Vilatela
authors.forename: Perla
authors.initials: P
authors.lastname: Salgado-Lujambio
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Barrios
mesh_terms: D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000378:metabolism; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
chemical_list: D006859:Hydrogen