Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis.
Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75-1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.
Yang
Dae Sik
DS
Department of Radiation Oncology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea.
Park
Kyong Hwa
KH
Woo
Ok Hee
OH
Woo
Sang Uk
SU
Kim
Ae-Ree
AR
Lee
Eun Sook
ES
Lee
Jae-Bok
JB
Kim
Yeul Hong
YH
Kim
Jun Suk
JS
Seo
Jae Hong
JH
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015233:Models, Statistical; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A