title: Multiple hemangiomas and hemangiomatosis--risk factors and outcome over an eight year period.
abstract: BACKGROUND
  Hemangiomas are the most common tumors of infancy. Multiple cutaneous hemangiomas may be associated with the presence of hemangiomas in inner organs. However, there is little data on the risk factors for organ involvement and the outcome of a large sample of patients.
  
  
  METHODS
  patients with 3 or more cutaneous hemangiomas were evaluated with regard to patient characteristics, distribution of hemangiomas, results of radiological abdominal/cerebral imaging, clinical course, and therapeutic approach. We analyzed the risk factors for organ involvement and complications/outcome.
  
  
  RESULTS
  The average gestational week at birth was 32.8; radiological imaging showed liver hemangiomas in 13.5% and mesenteric lesions in 1 (1.9%) but no cerebral lesions. Preterm infants (p=0.02) and patients with high numbers of cutaneous hemangiomas (p=0.02) were at higher risk of organ involvement. A life-threatening event occurred in 1 patient (1.9%). None of the patients died.
  
  
  CONCLUSIONS
  Organ manifestation is relatively common in patients with multiple hemangiomas, complications are rare, but potentially life-threatening. We recommend abdominal imaging for patients with 3 or more hemangiomas, especially in preterm infants.
authors.affiliation: University Hospital Heidelberg, Division of Pediatric Surgery, Heidelberg, Germany. Christine.Schupp@med.uni-heidelberg.de
authors.forename: C J
authors.initials: CJ
authors.lastname: Schupp
authors.forename: S
authors.initials: S
authors.lastname: Holland-Cunz
authors.forename: J-P
authors.initials: JP
authors.lastname: Schenk
authors.forename: H
authors.initials: H
authors.lastname: Weisser
authors.forename: D
authors.initials: D
authors.lastname: Grimm
authors.forename: P
authors.initials: P
authors.lastname: Günther
mesh_terms: D005260:Female; D006391:Hemangioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D016896:Treatment Outcome