title: Evaluation of melatonin on the precocious puberty: a pilot study.
abstract: OBJECTIVE
  To evaluate the effect of 6-sulphatoxymelatonin on the sleep quality of girls with precocious puberty.
  
  
  METHODS
  Ninety-nine girls were divided into three groups: GI, precocious puberty; GII, normal prepubescent; GIII, normal puberty. Questionnaires containing demographic and clinical data were applied. Blood was collected for hormonal evaluation for 6-sulphatoxymelatonin. The modified Rush Sleep Diary was used.
  
  
  RESULTS
  The levels of 6-sulphatoxymelatonin were highest in the group without pubertal development (75.23 ± 10.84 ng/ml), second highest in the group with normal puberty (45.66 ± 3.87 ng/ml, p < 0.001) and lowest in the group with true precocious puberty (37.04 ± 5.47 ng/ml). The amount of day sleep was greater in the group without pubertal development compared to other groups.
  
  
  CONCLUSIONS
  Despite the sleep data, melatonin may be involved in the precocious puberty process.
authors.affiliation: Divisão de Ginecologia da Infância e Adolescência, Department of Gynecology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
authors.forename: Felisbela Soares
authors.initials: FS
authors.lastname: de Holanda
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Magda
authors.initials: M
authors.lastname: Bignotto
authors.forename: Carla G
authors.initials: CG
authors.lastname: Maganhin
authors.forename: Lucia Helena Laprano
authors.initials: LH
authors.lastname: Vieira
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Baracat
authors.forename: José Maria
authors.initials: JM
authors.lastname: Soares
mesh_terms: D002648:Child; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D010865:Pilot Projects; D010907:Pituitary Hormones / Q000097:blood; D011629:Puberty, Precocious / Q000097:blood / Q000503:physiopathology / Q000652:urine*; D012893:Sleep Wake Disorders / Q000209:etiology; D011795:Surveys and Questionnaires
chemical_list: D012739:Gonadal Steroid Hormones; D010907:Pituitary Hormones; C054513:6-sulfatoxymelatonin; D008550:Melatonin