title: Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization.
abstract: Embryo implantation is an intricate interaction between receptive uterus and active blastocyst. The mechanism underlying embryo implantation is still unknown. Although histamine and putrescine are important for embryo implantation and decidualization, excess amount of histamine and putrescine is harmful. Amiloride binding protein 1 (Abp1) is a membrane-associated amine oxidase and mainly metabolizes histamine and putrescine. In this study, we first showed that Abp1 is strongly expressed in the decidua on d 5-8 of pregnancy. Abp1 expression is not detected during pseudopregnancy and under delayed implantation but is detected after estrogen activation. Because Abp1 is mainly localized in the decidua and also strongly expressed during in vitro decidualization, Abp1 might play a role during mouse decidualization. The regulation of estrogen on Abp1 is mediated by transcription factor CCAAT/enhancer-binding protein-β. Abp1 expression is also regulated by cAMP, bone morphogenetic protein 2, and ERK1/2. Abp1 may be essential for mouse embryo implantation and decidualization.
authors.affiliation: Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Science, Xiamen University, Xiamen 361005, China.
authors.forename: Xiao-Huan
authors.initials: XH
authors.lastname: Liang
authors.forename: Zhen-Ao
authors.initials: ZA
authors.lastname: Zhao
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Deng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tian
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
authors.forename: Xiu
authors.initials: X
authors.lastname: Xu
authors.forename: Xiu-Hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Ren-Wei
authors.initials: RW
authors.lastname: Su
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Yang
mesh_terms: D000584:Amiloride / Q000378:metabolism; D006631:Amine Oxidase (Copper-Containing) / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism / Q000502:physiology*; D002478:Cells, Cultured; D003605:D-Amino-Acid Oxidase / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D003656:Decidua / Q000187:drug effects* / Q000378:metabolism; D010064:Embryo Implantation / Q000187:drug effects* / Q000235:genetics; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005865:Gestational Age; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D008297:Male; D051379:Mice; D011247:Pregnancy / Q000235:genetics / Q000378:metabolism; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D000584:Amiloride; C485958:Dao1 protein, mouse; D006631:Amine Oxidase (Copper-Containing); D003605:D-Amino-Acid Oxidase