title: Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study.
abstract: BACKGROUND
  The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation rate, the concentration of fibrinogen and the white blood cell count.
  
  
  METHODS
  We have analyzed data collected between September 2002 and June 2009 in the Tel-Aviv medical center inflammation survey (TAMCIS). We recruited both apparently healthy individuals and individuals presenting with atherothrombotic risk factors. All participants were enrolled during their routine annual health check-up and gave their written informed consent. This is a cross sectional study in which we have fitted linear regression models using inflammatory markers as the dependant variables and adjust them according to the different components of the MetS and multiple other confounders.
  
  
  RESULTS
  Included were 12,072 individuals of whom there were 7,760 men at a mean (S.D.) age of 44 (11) years, and 4,312 women aged 44 (11) years. A significant correlation was noted between most components of the MetS and all inflammatory markers, the most significant one being with hs-CRP. In the multi-adjusted regression analysis, waist was the factor that best explained the variability of hs-CRP, in both women and men. It also remained a significant variable for the other inflammatory markers.
  
  
  CONCLUSIONS
  From amongst the various components of the MetS, waist circumference appears to exert the most influence upon the presence and intensity of the micro-inflammatory response.
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Ori
authors.initials: O
authors.lastname: Rogowski
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Itzhak
authors.initials: I
authors.lastname: Shapira
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Orit Kliuk-Ben
authors.initials: OK
authors.lastname: Bassat
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Tamar
authors.initials: T
authors.lastname: Chundadze
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Talya
authors.initials: T
authors.lastname: Finn
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
authors.affiliation: Departments of Internal Medicine "D" and "E", Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.|The Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, 6 Weizman street, Tel Aviv 64239, Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Steinvil