Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles.
The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.
Wang
Kan
K
Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, 3501 Fifth Avenue, BST1 11019, Pittsburgh, PA 1526, USA.
Dömling
Alexander
A
D000085:Acetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D015195:Drug Design; D009570:Nitriles / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry
D000085:Acetates; D000447:Aldehydes; D009570:Nitriles; D011758:Pyrroles; D013449:Sulfonamides; C000945:dicyanmethane; C007170:cyanoacetic acid