[Differences in serum and ascites cytokine production caused by Gram-positive or -negative bacterial infection in patients with multiple organ dysfunction syndrome].
OBJECTIVE
To observe the differences in the cytokine levels in the serum and ascites caused by Gram-positive or Gram-negative bacterial infection in patients with multiple organ dysfunction syndrome (MODS).


METHODS
The cytokines in the serum and ascites of the patients were examined by enzyme-linked immunosorbent assay in 27 patients with MODS due to Gram-positive (n=13) or Gram-negative (n=14) bacterial infection at day 1.


RESULTS
The levels of LPS and TNF-a were higher in the patients with Gram-negative bacterial infection than in patients with Gram-positive infection (P<0.05), but the levels of IL-6, IL-8 and IL-10 remained comparable between the two groups (P>0.05).


CONCLUSIONS
Testing of LPS and TNF-a in the serum and ascites of patients with MODS caused by Gram-positive or -negative bacterial infection may help to identify the pathogens for peritonitis resulting in MODS.
Qu
Rong
R
ICU of Huizhou Municipal Central Hospital, Huizhou 516001, China. hzqurong@126.com
Yang
Si-min
SM
Dai
Wei-qun
WQ
Ye
Chu-yang
CY
Ji
Yan
Y
D001201:Ascites / Q000378:metabolism*; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000378:metabolism; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D016209:Interleukin-8 / Q000097:blood / Q000378:metabolism; D009102:Multiple Organ Failure / Q000097:blood / Q000378:metabolism / Q000382:microbiology*; D044967:Serum / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10