title: Antiviral prophylaxis of neonatal herpes infection.
abstract: Herpes simplex virus (HSV) is considered to be one of the most frequent viral infectious agents in humans. Transmission of HSV from mother to foetus during pregnancy is uncommon with about 85% of transmission occurring perinatally, when neonates acquire HSV during vaginal birth from infected genital tract secretions. For women, who present with an episode of recurrent genital herpes several weeks before the expected delivery date, suppressive therapy with acyclovir or valacyclovir is recommended during the last 4 weeks of pregnancy. The study group consists of 21 women with recurrent genital tract herpes, who delivered between the years 2007-2009 at the Department of Obstetrics and Gynaecology, University Hospital Na Bulovce. Women in the last month of pregnancy were administered prophylactic viralstatic treatment with acyclovir 3 x 400 mg per day orally until delivery. In this study, no patient showed signs of acute lesions and viral DNA was not detectable on PCR in vaginal secretions. One woman delivered by acute caesarean section following signs of foetal hypoxia during the first stage of labour, two women were delivered by forceps. No newborns showed signs of HSV neonatal infection. Antiviral prophylaxis in the last month of pregnancy in women with recurrent genital herpes infection is considered to be safe and effective in the prevention of vulvar lesions and in decreasing the incidence of caesarean sections in this group of women.
authors.affiliation: Charles University in Prague, First Faculty of Medicine and University Hospital Na Bulovce, Department of Obstetrics and Gynaecology, Prague, Czech Republic. jozef.zahumensky@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Záhumenský
authors.forename: J
authors.initials: J
authors.lastname: Vlácil
authors.forename: M
authors.initials: M
authors.lastname: Holub
authors.forename: I
authors.initials: I
authors.lastname: Vasícka
authors.forename: N
authors.initials: N
authors.lastname: Sojková
authors.forename: M
authors.initials: M
authors.lastname: Halaska
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy; D006561:Herpes Simplex / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir