title: Rapid volumetric angiography of cortical microvasculature with optical coherence tomography.
abstract: We describe methods and algorithms for rapid volumetric imaging of cortical vasculature with optical coherence tomography (OCT). By optimizing system design, scanning protocols, and algorithms for visualization of capillary flow, comprehensive imaging of the surface pial vasculature and capillary bed is performed in approximately 12 s. By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated.
authors.affiliation: Photon Migration Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts 02129, USA. vjsriniv@nmr.mgh.harvard.edu
authors.forename: Vivek J
authors.initials: VJ
authors.lastname: Srinivasan
authors.forename: James Y
authors.initials: JY
authors.lastname: Jiang
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Yaseen
authors.forename: Harsha
authors.initials: H
authors.lastname: Radhakrishnan
authors.forename: Weicheng
authors.initials: W
authors.lastname: Wu
authors.forename: Scott
authors.initials: S
authors.lastname: Barry
authors.forename: Alex E
authors.initials: AE
authors.lastname: Cable
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging*; D021621:Imaging, Three-Dimensional; D051381:Rats; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*