A progressive declining in the burden of malaria in north-eastern Tanzania.
BACKGROUND
The planning and assessment of malaria interventions is complicated due to fluctuations in the burden of malaria over time. Recently, it has been reported that the burden of malaria in some parts of Africa has declined. However, community-based longitudinal data are sparse and the reasons for the apparent decline are not well understood.


METHODS
Malaria prevalence and morbidity have been monitored in two villages in north-eastern Tanzania; a lowland village and a highland village from 2003 to 2008. Trained village health workers treated presumptive malaria with the Tanzanian first-line anti-malarial drug and collected blood smears that were examined later. The prevalence of malaria parasitaemia across years was monitored through cross-sectional surveys.


RESULTS
The prevalence of malaria parasitaemia in the lowland village decreased from 78.4% in 2003 to 13.0% in 2008, whereas in the highland village, the prevalence of parasitaemia dropped from 24.7% to 3.1% in the same period. Similarly, the incidence of febrile malaria episodes in the two villages dropped by almost 85% during the same period and there was a marked reduction in the number of young children who suffered from anaemia in the lowland village.


CONCLUSIONS
There has been a marked decline in malaria in the study villages during the past few years. This decline is likely to be due to a combination of factors that include improved access to malaria treatment provided by the trained village helpers, protection from mosquitoes by increased availability of insecticide-impregnated bed nets and a reduced vector density. If this decline in malaria morbidity is sustained, it will have a marked effect on the disease burden in this part of Tanzania.
Mmbando
Bruno P
BP
National Institute for Medical Research, Tanga Centre, Tanga, Tanzania.
Vestergaard
Lasse S
LS
Kitua
Andrew Y
AY
Lemnge
Martha M
MM
Theander
Thor G
TG
Lusingu
John P A
JP
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D016015:Logistic Models; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D008297:Male; D008853:Microscopy; D009017:Morbidity; D009032:Mosquito Control / Q000379:methods; D018512:Parasitemia / Q000175:diagnosis / Q000453:epidemiology*; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D012424:Rural Population; D013636:Tanzania / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult