Effect of pu-erh tea on body fat and lipid profiles in rats with diet-induced obesity.
The antiobesity and antihyperlipidaemic effects of pu-erh tea in rats with high fat diet (HFD)-induced obesity were investigated. Male Sprague-Dawley rats were randomly divided into five groups and fed varying diets for an 8-week period: control diet, HFD, and HFD supplemented with low, moderate or high doses of pu-erh tea extract (0.5 g, 2 g and 4 g/kg BW/day, respectively). Pu-erh tea significantly reduced the total body weight and the weight of various adipose pads. Pu-erh tea administration also significantly lowered plasma total cholesterol, triglyceride concentrations and low-density lipoprotein-cholesterol levels in rats with HFD-induced obesity, but did not affect high-density lipoprotein-cholesterol levels. Moreover, pu-erh tea significantly increased lipoprotein lipase, hepatic lipase and hormone-sensitive lipase activities in epididymal fat tissue in rats with HFD-induced obesity. Analysis of real-time reverse transcription-polymerase chain reaction results indicated that pu-erh tea significantly enhanced mRNA levels of hormone-sensitive lipase in rats with HFD-induced obesity. These results suggest that pu-erh tea attenuated visceral fat accumulation and improved hyperlipidemia in a rat model of HFD-induced obesity.
Cao
Zhen-Hui
ZH
Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, People's Republic of China.
Gu
Da-Hai
DH
Lin
Qiu-Ye
QY
Xu
Zhi-Qiang
ZQ
Huang
Qi-Chao
QC
Rao
Hua
H
Liu
Er-Wei
EW
Jia
Jun-Jing
JJ
Ge
Chang-Rong
CR
D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004822:Epididymis / Q000187:drug effects; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050152:Intra-Abdominal Fat / Q000187:drug effects; D008049:Lipase / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
D019440:Anti-Obesity Agents; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D013662:Tea; D014280:Triglycerides; D008049:Lipase