title: Tubulointerstitial nephritis and uveitis in siblings.
abstract: OBJECTIVE
  To report on the occurrence of tubulointerstitial nephritis and uveitis (TINU) and HLA typing in two siblings.
  
  
  METHODS
  Retrospective case study.
  
  
  METHODS
  HLA typing from two siblings with TINU syndrome and their parents was performed on DNA from peripheral blood mononuclear cells (PBMC).
  
  
  RESULTS
  The boy developed TINU syndrome in 2001, his sister 5 years later. Both siblings inherited the HLA alleles HLA-DRB1*1401 and HLA-DQB1*0503 on the maternal haplotype, a haplotype that had rarely been observed in patients with TINU.
  
  
  CONCLUSIONS
  The observations support inheritance of HLA-linked risk factors of TINU, but indicate heterogeneity of the risk phenotype due to linkage with different reported haplotypes.
authors.affiliation: Centre for Ophthalmology, University Tuebingen, Schleichstrasse 12, Tuebingen, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Biester
authors.forename: Claudia
authors.initials: C
authors.lastname: Müller
authors.forename: Christoph M E
authors.initials: CM
authors.lastname: Deuter
authors.forename: Deshka
authors.initials: D
authors.lastname: Doycheva
authors.forename: Elke
authors.initials: E
authors.lastname: Altpeter
authors.forename: Manfred
authors.initials: M
authors.lastname: Zierhut
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000483:Alleles; D004334:Drug Administration Schedule; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000008:administration & dosage; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D010290:Parents; D010641:Phenotype; D011239:Prednisolone / Q000008:administration & dosage; D012189:Retrospective Studies; D035781:Siblings; D013577:Syndrome; D014606:Uveitis, Anterior / Q000235:genetics*
chemical_list: D005938:Glucocorticoids; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D011239:Prednisolone