title: Premature circuit clotting due to likely mechanical failure during continuous renal replacement therapy.
abstract: OBJECTIVE
  Failure of extracorporeal circuit (EC) function during continuous renal replacement therapy (CRRT) appears most likely due to progressive circuit clotting or, in some cases, most likely due to mechanical problems that affect flow. We aimed to study the incidence of such likely mechanical circuit failure (MCF).
  
  
  METHODS
  Retrospective observational study in an adult ICU of a tertiary hospital.
  
  
  METHODS
  We studied 30 patients treated with CRRT via femoral vein vascular access. We obtained information on age, gender, diagnosis, mode of CRRT, circuit life, and blood chemistry. We defined MCF as 'likely' if there was a reduction of between 60 and 80% in circuit life compared to the previous or following circuit life and 'very likely' if such a reduction was between 81 and 100%.
  
  
  RESULTS
  We studied 166 circuits in 30 different patients. Of these 26 were electively disconnected leaving 140 circuits with unplanned cessation of function. Among these circuits, likely MCF affected 10 circuits (7.1%) and very likely MCF affected 9 circuits (6.4%) for a total of 19 (13.6%) circuits.
  
  
  CONCLUSIONS
  Mechanical circuit failure appears to affect approximately 1 in 8 circuits. Prospective studies are needed to understand why MCF occurs.
authors.affiliation: Department of Intensive Care Medicine, Austin Hospital, Melbourne, Vic., Australia.
authors.forename: In Byung
authors.initials: IB
authors.lastname: Kim
authors.forename: Nigel
authors.initials: N
authors.lastname: Fealy
authors.forename: Ian
authors.initials: I
authors.lastname: Baldwin
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
mesh_terms: D000368:Aged; D001777:Blood Coagulation; D004868:Equipment Failure / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy / Q000295:instrumentation*; D012189:Retrospective Studies