title: Reticulated myxoid tumor of the tongue: 2 cases supporting an expanded clinical and immunophenotypic spectrum of ectomesenchymal chondromyxoid tumor of the tongue.
abstract: An ectomesenchymal chondromyxoid tumor (ECMT) is a rare neoplasm that exclusively occurs in the anterior dorsum of the tongue. The tumor consists of small round to fusiform or spindle cells with myxoid or chondroid stroma. The tumor consistently shows a positive reaction with glial fibrillary acidic protein antibodies, especially polyclonal antibodies. We report 2 cases of reticulated myxoid tumors arising in the tongue. One tumor occurred in the posterior dorsum of the tongue and another in the anterior. Both tumors showed characteristic morphology of ECMT; however, both were negative for reactions with monoclonal and polyclonal glial fibrillary acidic protein antibodies. On the basis of morphology, they are thought to be belonging to ECMT. Hence, we suggest that ECMT can show broader spectrum of clinical and immunophenotypic feature.
authors.affiliation: Departments of Dermatology, Pusan National University School of Medicine, Yangsan-si, Kyeongsangnam-do, Korea.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Seo
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Shin
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Kang
authors.forename: Kyung Un
authors.initials: KU
authors.lastname: Choi
authors.forename: Jee Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Do Youn
authors.initials: DY
authors.lastname: Park
authors.forename: Chang Hun
authors.initials: CH
authors.lastname: Lee
authors.forename: Mee Young
authors.initials: MY
authors.lastname: Sol
authors.forename: Jin Choon
authors.initials: JC
authors.lastname: Lee
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D009232:Myxoma / Q000378:metabolism / Q000473:pathology*; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein