title: Behavior of acetyl-L-carnitine injections (Nicetile fiale) with different drugs used for combined therapy.
abstract: BACKGROUND
  Acetyl-L-carnitine (Nicetile fiale; Biofutura Pharma S.p.A., Sigma Tau group, Milano, Italy) is a compound widely used for the treatment of many diseases, such as neuropathies, diabetic polyneuropathy, and Parkinson's disease. It is frequently administered via the intramuscular route with other drugs, such as steroidal anti.inflammatories, muscle relaxants, and vitamins.
  
  
  METHODS
  In the present study the behavior of acetyl-L-carnitine injections (Nicetile fiale) with different drugs used for combined therapy was studied. Physicochemical properties including color, clarity, pH, and drug content were observed before and after mixing at room temperature.
  
  
  RESULTS
  The content of all the active drugs after mixing remained optimal within 10% of their nominal values.
  
  
  CONCLUSIONS
  The measurements demonstrate the physicochemical compatibility between Nicetile fiale and the other tested products, meaning that there is no evidence of interactions and degradation.
authors.affiliation: Department of Pharmaceutical Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy. s.sinicropi@unical.it
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Sinicropi
authors.forename: Francesco
authors.initials: F
authors.lastname: Leone
authors.forename: Nicola
authors.initials: N
authors.lastname: Rovito
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Genchi
mesh_terms: D000108:Acetylcarnitine / Q000737:chemistry / Q000493:pharmacokinetics; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001812:Blood-Brain Barrier / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D004338:Drug Combinations; D004339:Drug Compounding / Q000592:standards; D004344:Drug Incompatibility; D004355:Drug Stability; D005938:Glucocorticoids / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D009465:Neuromuscular Agents / Q000737:chemistry; D018697:Nootropic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D014815:Vitamins / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D005938:Glucocorticoids; D009465:Neuromuscular Agents; D018697:Nootropic Agents; D014815:Vitamins; D000108:Acetylcarnitine