In vitro genotoxicity and cytotoxicity of five new chemical compounds of plant origin by means of the human lymphocyte micronucleus assay.
The micronucleus test in human peripheral lymphocytes is widely used in toxicology for the assessment of the genotoxic profile of chemical compounds of environmental concern. The aim of this study was to evaluate the genotoxic, cytotoxic and antimitotic activity of five new compounds isolated from Prunus africana Hook or from Bupleurum fruticosum L. The experiments were conducted only in vitro. Results showed that none of the plant extracts, tested over a wide range of concentrations, increased the frequency of micronuclei. Only compounds 2 and 5 were found to be toxic for phytohaemagglutinin-stimulated lymphocytes at the maximum dose used. reserved.
Scarpato
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Dipartimento di Scienze dell'Uomo e dell'Ambiente, Università di Pisa, Italy.
Pistelli
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Bertoli
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Nieri
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Migliore
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