title: Nanoshell-mediated laser surgery simulation for prostate cancer treatment.
abstract: Laser surgery, or laser-induced thermal therapy, is a minimally invasive alternative or adjuvant to surgical resection in treating tumors embedded in vital organs with poorly defined boundaries. Its use, however, is limited due to the lack of precise control of heating and slow rate of thermal diffusion in the tissue. Nanoparticles, such as nanoshells, can act as intense heat absorbers when they are injected into tumors. These nanoshells can enhance thermal energy deposition into target regions to improve the ability for destroying larger cancerous tissue volumes with lower thermal doses. The goal of this paper is to present an integrated computer model using a so-called nested-block optimization algorithm to simulate laser surgery and provide transient temperature field predictions. In particular, this algorithm aims to capture changes in optical and thermal properties due to nanoshell inclusion and tissue property variation during laser surgery. Numerical results show that this model is able to characterize variation of tissue properties for laser surgical procedures and predict transient temperature fields comparable to those measured by in vivo magnetic resonance temperature imaging techniques. Note that the computational approach presented in the study is quite general and can be applied to other types of nanoparticle inclusions.
authors.affiliation: Computational Bioengineering and Nanotechnology Lab, Department of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA yusheng.feng@utsa.edu.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Feng
authors.forename: David
authors.initials: D
authors.lastname: Fuentes
authors.forename: Andrea
authors.initials: A
authors.lastname: Hawkins
authors.forename: Jon
authors.initials: J
authors.lastname: Bass
authors.forename: Marissa Nichole
authors.initials: MN
authors.lastname: Rylander
authors.forename: Andrew
authors.initials: A
authors.lastname: Elliott
authors.forename: Anil
authors.initials: A
authors.lastname: Shetty
authors.forename: R Jason
authors.initials: RJ
authors.lastname: Stafford
authors.forename: J Tinsley
authors.initials: JT
authors.lastname: Oden