title: [Synthesis, modifications, and antimicrobial activity of the methylpiperazinyl amides of triterpenic acids].
abstract: N-Methylpiperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against Klebsiella pneumoniae at a concentration of 60 mg/ml. Among the studied N-methylpiperazinyl amides, the highest activity against S. aureus was observed for a betulonic acid derivative.
authors.forename: O B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: G V
authors.initials: GV
authors.lastname: Giniiatullina
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
authors.forename: N I
authors.initials: NI
authors.lastname: Medvedeva
authors.forename: T M
authors.initials: TM
authors.lastname: Utkina
authors.forename: O L
authors.initials: OL
authors.lastname: Kartashova
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015169:Colony Count, Microbial; D007711:Klebsiella pneumoniae / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D010879:Piperazines; D014315:Triterpenes