Effects of escin mixture from the seeds of Aesculus hippocastanum on obesity in mice fed a high fat diet.
Escins, a triterpene glycoside mixture obtained from the ethanol extract of Aesculus hippocastanum L. (Hippocastanaceae) seed, was evaluated for its in vivo effects on the plasma levels of some hormones (leptin, insulin, FT(3), FT(4)) and biochemical parameters (glucose, triglyceride, total cholesterol, HDL-C, LDL-C concentrations) in mice fed with a high fat diet for 5 weeks. A high fat diet induced a remarkable increment in the plasma leptin (p <0.01), total cholesterol (p <0.01) and LDL-C (p <0.001) concentrations compared to control group animals. Combined administration of a high-fat diet with escins decreased leptin (31.6%) (p<0.05) and FT(4) (36.0%) (p<0.05) levels, increased HDL-C concentration (17.0%), while remained ineffective on LDL-C concentration in mice. Results have shown that escins may have beneficial effects in the understanding of obesity.
Avci
Gülcan
G
Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Küçükkurt
Ismail
I
Küpeli Akkol
Esra
E
Yeşilada
Erdem
E
D031319:Aesculus / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D004928:Escin / Q000302:isolation & purification / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009765:Obesity / Q000097:blood / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D012639:Seeds / Q000737:chemistry*; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors; D014421:Turkey
D019440:Anti-Obesity Agents; D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D008055:Lipids; D008074:Lipoproteins; D010936:Plant Extracts; D013963:Thyroid Hormones; C030104:lipoprotein cholesterol; D004928:Escin; D002784:Cholesterol