Uric Acid as prognostic marker in advanced nonischemic dilated cardiomyopathy: comparison with N-terminal pro B-type natriuretic peptide level.
Although uric acid (UA) level has been associated with an increased risk of cardiovascular events, it is unclear whether UA can provide greater prognostic information than N-terminal pro B-type natriuretic peptide (NT-proBNP) in advanced heart failure with nonischemic dilated cardiomyopathy (DCM). UA and NT-proBNP values were obtained from a total of 122 DCM patients. Development of clinical events during follow-up was defined as the composite of cardiac death and readmission for heart failure. During follow-up, there were 18 cardiac events. UA and NT-proBNP values were significantly higher in patients with events. The receiver operating characteristics curve showed the area under the curve for UA was greater than that for NT-proBNP. On multivariate analysis, UA remained the only independent predictor of prognosis. UA concentrations > or =8.7 mg/dL rather than NT-proBNP > or =3800 pg/mL were associated with significantly decreased event-free survival. The authors' findings demonstrated that UA value could be an informative predictor in nonischemic DCM.
Kim
Hyungseop
H
Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea. khyungseop@dsmc.or.kr
Shin
Hong-Won
HW
Son
Jihyun
J
Yoon
Hyuck-Jun
HJ
Park
Hyoung-Seob
HS
Cho
Yun-Kyeong
YK
Han
Choon-Duk
CD
Nam
Chang-Wook
CW
Hur
Seung-Ho
SH
Kim
Yoon-Nyun
YN
Kim
Kwon-Bae
KB
D015415:Biomarkers; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000175:diagnosis; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006305:Health Status Indicators; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013223:Statistics as Topic; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014527:Uric Acid