Innate inflammatory response to the malarial pigment hemozoin.
Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host's innate inflammatory responses.
Shio
Marina T
MT
Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.
Kassa
Fikregabrail A
FA
Bellemare
Marie-Josée
MJ
Olivier
Martin
M
D006420:Hemeproteins / Q000096:biosynthesis / Q000138:chemical synthesis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*
D006420:Hemeproteins; C020753:hemozoin