Poly(2-hydroxyethyl methacrylate-co-dodecyl methacrylate-co-acrylic acid): synthesis, physico-chemical characterisation and nafcillin carrier.
In the present study polymeric microbeads of poly(2-hydroxyethyl methacrylate-co-dodecyl methacrylate-co-acrylic acid) or p(HEMA-co-dDMA-co-AA) were synthesised and characterized through FT-IR and scanning electron microscopy (SEM); their swelling behavior against saline solution was explored and their in vitro cytotoxicity was evaluated. Further, in order to elucidate kinetic aspects regarding the ternary system p(HEMA-co-dDMA-co-AA), a mathematical model of the reactivity ratios of the comonomers in the terpolymer has been conceived and analyzed. An intensified tendency of AA units accumulation in the copolymer has been noticed, in spite of HEMA units, while dDMA conserves in the copolymer the fraction from the feed. Three compositions have been selected for nafcillin-loading and their in vitro release capacity was evaluated. The compositions of 80:10:10 and 75:10:15 M ratios appear suitable for further in vivo testing, in order to be used as drug delivery systems in the treatment of different osseous diseases.
Zecheru
Teodora
T
University Politehnica of Bucharest, Bucharest, Romania.
Rotariu
Traian
T
Rusen
Edina
E
Mărculescu
Bogdan
B
Miculescu
Florin
F
Alexandrescu
Laura
L
Antoniac
Iulian
I
Stancu
Izabela-Cristina
IC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001847:Bone Diseases / Q000188:drug therapy; D002460:Cell Line; D055598:Chemical Phenomena; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009254:Nafcillin / Q000008:administration & dosage*; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011355:Prodrugs / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D008689:Methacrylates; D011108:Polymers; D011355:Prodrugs; C115846:dodecyl methacrylate; D011102:Polyhydroxyethyl Methacrylate; D009254:Nafcillin