Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines.
New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
Kabri
Youssef
Y
Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d'Aix-Marseille I, II et III - UMR CNRS 6264, Marseille cedex 05, France. youssef.kabri@univmed.fr
Verhaeghe
Pierre
P
Gellis
Armand
A
Vanelle
Patrice
P
D002384:Catalysis; D008872:Microwaves; D055601:Organic Chemistry Phenomena; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis; D011799:Quinazolines / Q000138:chemical synthesis*
D004364:Pharmaceutical Preparations; D011799:Quinazolines