Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
Conde
Lucia
L
School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Halperin
Eran
E
Akers
Nicholas K
NK
Brown
Kevin M
KM
Smedby
Karin E
KE
Rothman
Nathaniel
N
Nieters
Alexandra
A
Slager
Susan L
SL
Brooks-Wilson
Angela
A
Agana
Luz
L
Riby
Jacques
J
Liu
Jianjun
J
Adami
Hans-Olov
HO
Darabi
Hatef
H
Hjalgrim
Henrik
H
Low
Hui-Qi
HQ
Humphreys
Keith
K
Melbye
Mads
M
Chang
Ellen T
ET
Glimelius
Bengt
B
Cozen
Wendy
W
Davis
Scott
S
Hartge
Patricia
P
Morton
Lindsay M
LM
Schenk
Maryjean
M
Wang
Sophia S
SS
Armstrong
Bruce
B
Kricker
Anne
A
Milliken
Sam
S
Purdue
Mark P
MP
Vajdic
Claire M
CM
Boyle
Peter
P
Lan
Qing
Q
Zahm
Shelia H
SH
Zhang
Yawei
Y
Zheng
Tongzhang
T
Becker
Nikolaus
N
Benavente
Yolanda
Y
Boffetta
Paolo
P
Brennan
Paul
P
Butterbach
Katja
K
Cocco
Pierluigi
P
Foretova
Lenka
L
Maynadié
Marc
M
de Sanjosé
Silvia
S
Staines
Anthony
A
Spinelli
John J
JJ
Achenbach
Sara J
SJ
Call
Timothy G
TG
Camp
Nicola J
NJ
Glenn
Martha
M
Caporaso
Neil E
NE
Cerhan
James R
JR
Cunningham
Julie M
JM
Goldin
Lynn R
LR
Hanson
Curtis A
CA
Kay
Neil E
NE
Lanasa
Mark C
MC
Leis
Jose F
JF
Marti
Gerald E
GE
Rabe
Kari G
KG
Rassenti
Laura Z
LZ
Spector
Logan G
LG
Strom
Sara S
SS
Vachon
Celine M
CM
Weinberg
J Brice
JB
Holly
Elizabeth A
EA
Chanock
Stephen
S
Smith
Martyn T
MT
Bracci
Paige M
PM
Skibola
Christine F
CF
D004198:Disease Susceptibility; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D008224:Lymphoma, Follicular / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics; D008285:Major Histocompatibility Complex; D012307:Risk Factors