[Diabetes mellitus, antidiabetics and bone].
A short review of current opinions on a questionable and controversial disease--diabetic osteopathy--is presented. Bone metabolism is influenced by antidiabetic drugs. Positive effects are attributed to the insulin and metformin therapy. Use of thiazolidindiones is accompanied by a higher risk of bone fractures in diabetic women. Very interesting and also promising is the effect of glucagon like peptide-1 and the new antidiabetic drug class- incretin analogues on bone metabolism.
Svacina
Stepán
S
Univerzita Karlova v Praze, 1. lékarská fakulta, III. interní klinika VFN. svacinas@lf1.cuni.cz
D001851:Bone Diseases, Metabolic / Q000209:etiology*; D001842:Bone and Bones / Q000187:drug effects*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D045162:Thiazolidinediones / Q000009:adverse effects / Q000627:therapeutic use
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones