[The effects of different hydration strategies before endovascular treatments to the renal function of the arteriosclerosis obliterans patients].
OBJECTIVE
To compare the efficacies of different hydration strategies in protecting the renal function of the arteriosclerosis obliterans (ASO) patients undergoing endovascular treatments.


METHODS
40 patients who underwent endovascular treatments for arteriosclerosis obliterans of lower extremities in the Vascular Surgery Department of PLA Hospital from January 2009 to October 2009 were divided into normal (serum creatinine < or = 110 micromol/L) and abnormal (serum creatine > 110 micromol/L) groups according to their baseline serum concentration of creatinine before treatments. Each group was treated by different hydration strategies 12 h before procedures. Changes of serum creatinine and creatinine clearance were measured 6, 24, 48 h after procedures to evaluate the changes of renal function and the effects of different hydration strategies.


RESULTS
No contrast-induced nephropathy (CIN) was observed among the 40 patients. There are significant differences between normal saline hydration group and control group in the changes of serum creatinine and creatinine clearance 24 h and 48 h after exposure to contrast medium for the normal renal function patients (P < 0.05). For the patients pre-existing renal dysfunction, no significant difference was found between Sodium Bicarbonate + Saline group and Saline group in the changes of Scr and Ccr 6, 24, 48 h after exposure to contrast medium (P > 0.05).


CONCLUSIONS
Sodium chloride provides a good efficacy for preventing the adverse effect of contrast medium to the renal function of the ASO patients. For the patients pre-existing renal dysfunction, Combination hydration with sodium bicarbonate is not more effective than normal saline alone in preventing contrast-induced renal dysfunction.
Zhu
Ya-ting
YT
The Vascular Surgery Department of the People's Liberation Army (PLA) General Hospital, Beijing 100853, China.
Xiong
Jiang
J
Guo
Wei
W
Liu
Xiao-ping
XP
Yin
Tai
T
Jia
Xin
X
Ma
Xiao-hui
XH
DU
Xin
X
D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000503:physiopathology* / Q000628:therapy*; D003287:Contrast Media / Q000009:adverse effects; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007677:Kidney Function Tests; D035002:Lower Extremity / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*
D003287:Contrast Media; D012965:Sodium Chloride