[Optical spectroscopy: a new approach to assess urological tumors].
BACKGROUND
Optical spectroscopy refers to a group of novel technologies that uses interaction of light with tissues to analyze their structure and chemical composition. The objective of this article is to describe these technologies and detail their potential for assessing urological tumors.


METHODS
It has been shown that optical spectroscopy can accurately analyse multiple solid tumors. Several publications specifically aimed at assessing prostate cancers, renal carcinomas and urothelial tumors.


RESULTS
There are three types of spectroscopy that all use light focussed on a tissue and thereafter collect a specific reflected optical signal. Optical spectroscopy can differentiate benign (adenoma or inflammation) and malignant (adenocarcinoma) prostatic tissues. It can also distinguish normal bladder tissue from inflammatory or cancerous cells. Regarding renal tumors, spectroscopy can identify normal and tumoral tissue and differentiate benign and malignant tumors. Its diagnostic accuracy is about 85%. However, reported studies only concentrate on in vitro or ex vivo specimen and the numbers of patients are quite small.


CONCLUSIONS
Optical spectroscopy can be envisioned as an "optical biopsy" tool. Potential applications in the clinical field are promising. Larger studies on in vivo specimen need to be undertaken to confirm phase I preliminary reports.
Bensalah
K
K
Inserm U642, laboratoire du traitement du signal et de l'image, université Rennes I, 2, rue Henri-Le-Guilloux, 35000 Rennes, France. Karim.bensalah@chu-rennes.fr
Fleureau
J
J
Rolland
D
D
Rioux-Leclercq
N
N
Senhadji
L
L
Lavastre
O
O
Guillé
F
F
Patard
J-J
JJ
de Crevoisier
R
R
D004867:Equipment Design; D006801:Humans; D013059:Spectrum Analysis, Raman / Q000295:instrumentation; D014571:Urologic Neoplasms / Q000473:pathology*