[Hoxc13 and the development of hair follicle].
Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP (keratin) and KAP (keratin-associated protein) expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two types of hair proteins and maintaining the normal morphology of hair follicle. In this review, we summarized that the relationship between the expression level of Hoxc13 and hair follicle development/hair growth and the mechanisim under the controling of Hoxc13 and relevant genes.
Wu
Jiang-Hong
JH
College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China. wujianghonglong@126.com
Yan
Zu-Wei
ZW
Husile
Zhang
Wen-Guang
WG
Li
Jin-Quan
JQ
D000818:Animals; D018859:Hair Follicle / Q000254:growth & development* / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008954:Models, Biological
C410305:HOXC13 protein, human; D018398:Homeodomain Proteins; D007633:Keratins