title: Protective activity of Jiang-Zhi-Li-Gan against carbon tetrachloride-induced hepatic injury in mice.
abstract: The administration of carbon tetrachloride (CCl(4)) to mice produced hepatotoxicity, showing a significant increase in the serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST). Mice pretreated with Jiang-Zhi-Li-Gan (JZLG, 100-900 mg/kg, p.o.), a domestic remedy for liver disease in Rui-Jin Hospital, showed a significant decrease in serum ALT and AST levels when compared to the group treated with CCl(4) alone. The standard drug, bifendate (200 mg/kg, p.o.), also exhibited similar results. In the acute toxicity study, JZLG did not show any mortality up to a dose of 32 g/kg body weight. Based on the results obtained, it can be concluded that JZLG seems to possess hepatoprotective activity in mice. These results support the use of this prescription against chemical hepatic injury.
authors.affiliation: Department of Pharmacy, Fudan University Cancer Hospital, Shanghai, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhai
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Bian
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D011897:Random Allocation; D023382:Toxicity Tests, Acute
chemical_list: D004365:Drugs, Chinese Herbal; D020011:Protective Agents; C553648:jiang-zhi-li-gan; D002251:Carbon Tetrachloride