[Classification and pathophysiology of pituitary adenomas].
Pituitary adenomas are benign tumors that can be classified according to the type of hormone they produce, immunocytochemical characteristics (which generally confirm the clinical classification) or, as proposed by WHO in 2004, specific differentiation markers of the various ligneages. The pathophysiology of pituitary adenomas is largely unknown. Although a clonal origin is very likely, no univocal molecular abnormality (except for gsp mutations, found in 40% of somatotropic adenomas) has yet been found. Studies of cell cycle proteins, growth factors and oncogenes are beginning to shed light on the complex underlying mechanisms.
Galland
Françoise
F
Endocrinologie et des Maladies de la Reproduction, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre F-94275, France.
Chanson
Philippe
P
D000236:Adenoma / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008297:Male; D051379:Mice; D047495:PPAR gamma / Q000187:drug effects / Q000502:physiology; D010911:Pituitary Neoplasms / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D040901:Proteomics; D011960:Receptors, Estrogen / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D014944:World Health Organization
D018797:Cell Cycle Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047495:PPAR gamma; D011960:Receptors, Estrogen; D017978:Receptors, Growth Factor