title: Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
authors.affiliation: Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Torino, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Boschi
authors.forename: Marta
authors.initials: M
authors.lastname: Giorgis
authors.forename: Clara
authors.initials: C
authors.lastname: Cena
authors.forename: Naveen Chandra
authors.initials: NC
authors.lastname: Talniya
authors.forename: Antonella
authors.initials: A
authors.lastname: Di Stilo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Morini
authors.forename: Gabriella
authors.initials: G
authors.lastname: Coruzzi
authors.forename: Elena
authors.initials: E
authors.lastname: Guaita
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Alberto
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D007975:Leukotriene B4 / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D016859:Lipoxygenase Inhibitors; D007975:Leukotriene B4; D009569:Nitric Oxide; D001094:Arachidonate 5-Lipoxygenase; C063449:zileuton; D006918:Hydroxyurea