title: Design and synthesis of HCV agents with sequential triple inhibitory potentials.
abstract: The union of HCV-796, a potent selective HCV NS5B polymerase inhibitor, and Ribavirin, a molecule with activities against a wide spectrum of viruses, resulted in a class of new anti-HCV agents with a sequential triple inhibitory mechanism.
authors.affiliation: Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA.
authors.forename: Tianmin
authors.initials: T
authors.lastname: Zhu
authors.forename: Mahdi B
authors.initials: MB
authors.lastname: Fawzi
authors.forename: Michael
authors.initials: M
authors.lastname: Flint
authors.forename: Fangming
authors.initials: F
authors.lastname: Kong
authors.forename: Jan
authors.initials: J
authors.lastname: Szeliga
authors.forename: Russ
authors.initials: R
authors.lastname: Tsao
authors.forename: Anita Y M
authors.initials: AY
authors.lastname: Howe
authors.forename: Weitao
authors.initials: W
authors.lastname: Pan
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents