title: Comment on "Developing DCE-CT to quantify intra-tumor heterogeneity in breast tumors with differing angiogenic phenotype".
abstract: In our comment some essential issues concerning determination of arterial input function (AIF), cardiac and respiratory related motion artifacts, contrast agent application and compartmental model fitting done by Cao et al., 2009 are discussed.
authors.forename: Andrij
authors.initials: A
authors.lastname: Abramyuk
authors.forename: Gunter
authors.initials: G
authors.lastname: Wolf
authors.forename: Volker
authors.initials: V
authors.lastname: Hietschold
authors.forename: Ulrike
authors.initials: U
authors.lastname: Haberland
authors.forename: Joerg
authors.initials: J
authors.lastname: van den Hoff
authors.forename: Nasreddin
authors.initials: N
authors.lastname: Abolmaali
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007479:Iopamidol / Q000008:administration & dosage / Q000493:pharmacokinetics; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology*; D010641:Phenotype; D049268:Positron-Emission Tomography; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014183:Transplantation, Heterologous
chemical_list: D003287:Contrast Media; D007479:Iopamidol