title: Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats.
abstract: The objective of this study was to investigate the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives (PDs) compared with paliperidone and risperidone. The i.g. LD(50) and i.v. maximum tolerated doses of PD1, PD5 and PD6 were greater than those of paliperidone and risperidone in mice. Pharmacokinetic study showed that PDs were quickly metabolized to paliperidone to take effect in the treatment of schizophrenia in rats after i.g. administration. Only traces of the parent substances were found. Pharmacodynamic study showed that PDs significantly reduced MK-801-induced hyperlocomotion in mice. The electrocardiogram (ECG) was recorded at 0, 5, 10, 15, 20, 25, 30, 45 and 60 min. in anaesthetized rats after i.v. injection of 0.21, 0.59, 1.69 micromol/kg drugs. Heart rate reduction had a linear relation with dose after i.v. injection of PDs, paliperidone and risperidone. No significant change in the ECG parameters was found in all groups after administration of the low dose. Although the reductions in heart rate and the corrected QT interval (QTc) were observed in all drugs at the high dose, PD5 and PD6 were associated with smaller effects on the ECG parameters than other compounds, including paliperidone and risperidone. Therefore, PD5 and PD6 could be potential candidates for the treatment of schizophrenia.
authors.affiliation: College of Life Science, Jilin University, Changchun, China.
authors.forename: Fengying
authors.initials: F
authors.lastname: Sun
authors.forename: Zhengxing
authors.initials: Z
authors.lastname: Su
authors.forename: Cheng
authors.initials: C
authors.lastname: Sui
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Lijia
authors.initials: L
authors.lastname: Yuan
authors.forename: Qingfan
authors.initials: Q
authors.lastname: Meng
authors.forename: Lirong
authors.initials: L
authors.lastname: Teng
authors.forename: Youxin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004562:Electrocardiography; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006948:Hyperkinesis / Q000139:chemically induced; D007555:Isoxazoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D020714:Maximum Tolerated Dose; D051379:Mice; D008815:Mice, Inbred Strains; D000068882:Paliperidone Palmitate; D011743:Pyrimidines / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D018967:Risperidone / Q000493:pharmacokinetics / Q000633:toxicity*; D012559:Schizophrenia / Q000188:drug therapy; D023382:Toxicity Tests, Acute
chemical_list: D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D007555:Isoxazoles; D011743:Pyrimidines; D016291:Dizocilpine Maleate; D018967:Risperidone; D000068882:Paliperidone Palmitate