title: Recurrence during pregnancy of a conservatively treated early-stage cervical squamous cell carcinoma.
abstract: OBJECTIVE
  To evaluate the safety of conservative management of early cervical cancer.
  
  
  METHODS
  Case report and analysis of literature guidelines.
  
  
  METHODS
  Academic teaching hospital.
  
  
  METHODS
  A 35-year-old, nulliparous woman treated by simple trachelectomy and pelvic lymphadenectomy for a well-differentiated, 12-mm squamous cell carcinoma infiltrating to a depth of 3 mm (stage Ib1) without lymphovascular space involvement.
  
  
  METHODS
  Follow-up.
  
  
  METHODS
  Recurrence and disease evolution.
  
  
  RESULTS
  Sixteen months after surgery, at 32 weeks' gestation, a local recurrence of 5 cm in diameter was diagnosed, associated with pelvic and interaortocaval lymph node involvement. Despite extensive radiotherapy, chemotherapy, and radical surgery, disease progression could not be halted.
  
  
  CONCLUSIONS
  We report a case of early-stage cervical cancer, conservatively treated by simple trachelectomy and lymphadenectomy, that recurred although none of the known risk factors for recurrence were initially present, and despite the fact that literature guidelines were followed.
authors.affiliation: Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Pascale
authors.initials: P
authors.lastname: Jadoul
authors.forename: Denis
authors.initials: D
authors.lastname: Querleu
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Squifflet
authors.forename: Jacques
authors.initials: J
authors.lastname: Donnez
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D018450:Disease Progression; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D010166:Palliative Care; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy