Medicinal chemistry as a conduit for the modulation of quorum sensing.
Lowery
Colin A
CA
Department of Chemistry and Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA.
Salzameda
Nicholas T
NT
Sawada
Daisuke
D
Kaufmann
Gunnar F
GF
Janda
Kim D
KD
D054742:Acyl-Butyrolactones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D055808:Drug Discovery; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006714:Homoserine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010420:Pentanes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D053038:Quorum Sensing / Q000187:drug effects*; D013329:Structure-Activity Relationship
C493138:4,5-dihydroxy-2,3-pentanedione; D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D010420:Pentanes; D010456:Peptides, Cyclic; D006714:Homoserine