title: Histopathological effects of estrogen deficiency on larynx mucosa in ovariectomised rats.
abstract: Laryngeal manifestations due to estrogen deficiency have been studied in the literature. But to date, the possible histopathological changes of laryngeal mucosa due to estrogen deficiency have not been studied. Therefore, our objective was to determine the histopathological changes of laryngeal mucosa in ovariectomised rats in order to clarify effects of estrogen deficiency on laryngeal tissue. The study is a randomized trial and was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Twenty-one Wistar rats were used throughout the experiment. There were six rats in the sham-operated control group. And others were divided into two groups (4, 8 weeks) according to follow-up time after ovariectomy. We observed significant changes 4 weeks after ovariectomy when we assessed subepithelial edema, inflammation, cilia and goblet cell loss (p < 0.01). It was shown that estrogen deficiency after ovariectomy in rats caused changes in laryngeal tissue when it was studied histopathologically.
authors.affiliation: Department of Otorhinolaryngology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Surmeli
authors.forename: Tulay Erden
authors.initials: TE
authors.lastname: Habesoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Habesoglu
authors.forename: Ildem
authors.initials: I
authors.lastname: Deveci
authors.forename: Murat
authors.initials: M
authors.lastname: Eriman
authors.forename: Vefa
authors.initials: V
authors.lastname: Kinis
authors.forename: Pembegul
authors.initials: P
authors.lastname: Gunes
authors.forename: Erol
authors.initials: E
authors.lastname: Egeli
mesh_terms: D000818:Animals; D002923:Cilia; D004487:Edema / Q000473:pathology; D004967:Estrogens / Q000172:deficiency* / Q000502:physiology; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D007820:Laryngeal Mucosa / Q000473:pathology*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004967:Estrogens