title: [A case of cervical lymph node recurrence of advanced gastric cancer responding to combination therapy of S-1, CDDP and docetaxel].
abstract: A 57-year-old man underwent total gastrectomy with D2 lymphadenectomy for advanced gastric cancer. The post operative diagnosis was Stage IIIB (tubular adenocarcinoma, moderately-differentiated type, SE, N2, M0). The patient's postoperative course was uneventful, and S-1 was administered as adjuvant chemotherapy. However, about 14 months later, a gradual left cervical lymph node swelling became evident, with an increase in the level of the tumor marker CA19-9, suggesting recurrence of the gastric cancer. After obtaining informed consent, S-1 (100 mg/body), cisplatin (60 mg/m2), and docetaxel (40 mg/m2) combination chemotherapy (DCS) was performed. After 5 courses of DCS, the patient's swollen left cervical lymph nodes became non-palpable, and also undetectable by diagnostic imaging, together with normalization of the CA19-9 level. At three months since the last chemotherapy, the patient showed no signs of recurrence. DCS is a potentially effective treatment for recurrent gastric cancer with resistance to S-1.
authors.affiliation: Department of Surgery, Division of Gastrointestinal Surgery and Surgical Oncology, Ehime University Graduate School of Medicine.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugishita
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishida
authors.forename: Motohira
authors.initials: M
authors.lastname: Yoshida
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Doi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Horiuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D000077143:Docetaxel; D004338:Drug Combinations; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology*; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D012008:Recurrence; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use*; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D002945:Cisplatin