Peroxyl radical scavenging activity of the antihypertensive drug carvedilol.
The antihypertensive drug carvedilol was tested for its ability to scavenge peroxyl radicals by use of the model radical trichloromethyl peroxyl (CC1(3)O(2)). Carvedilol scavenged CC1(3)O(2) with a calculated rate constant of 1.5 +- 0.1 x 10(7)/M(-1) sec(-1). This ability to react rapidly with peroxyl radicals might be one mechanism by which carvedilol inhibits lipid peroxidation accounting for its reported antioxidant activity.
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Pharmacology Group, University of London King's College, Manresa Road, London SW3 6LX, UK.