title: Enantioselective nickel-catalyzed reductive coupling of alkynes and imines.
abstract: The nickel-catalyzed reductive coupling of alkynes and imines with Et(2)Zn as a reductant by using electron-rich phosphine ligands has been developed, affording various allylic amines with high yields and excellent chemoselectivities. Chiral induction was also achieved in this reductive coupling reaction when a nickel catalyst containing a chiral spiro phosphine ligand was used.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Chang-Yue
authors.initials: CY
authors.lastname: Zhou
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000480:Alkynes; D000588:Amines; D007097:Imines; D009532:Nickel