Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients.
Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.
Nassimizadeh
Mohammad
M
Cardiovascular Medicine Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Ashrafian
Houman
H
Drury
Nigel E
NE
Howell
Neil J
NJ
Digby
Janet
J
Pagano
Domenico
D
Frenneaux
Michael P
MP
Born
Gustav V R
GV
D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003925:Diabetic Angiopathies / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000737:chemistry* / Q000648:ultrastructure; D005293:Ferritins; D019276:Glycocalyx / Q000378:metabolism; D006801:Humans; D008323:Mammary Arteries / Q000737:chemistry* / Q000648:ultrastructure; D008854:Microscopy, Electron; D019158:N-Acetylneuraminic Acid / Q000097:blood; D013194:Staining and Labeling / Q000379:methods; D013499:Surface Properties
D005293:Ferritins; D019158:N-Acetylneuraminic Acid