Anti-inflammatory effect of Stereospermum suaveolens ethanol extract in rats.
The anti-inflammatory effect of the ethanol extract of Stereospermum suaveolens (Roxb.) DC (Bignoniaceae) bark given orally at the dose of 200 and 400 mg/kg body weight was studied in rats using the carrageenan-, dextran-, and histamine-induced hind paw edema, and cotton pellet-induced granuloma formation models. Indomethcin at the dose of 10 mg/kg body weight was used as a standard drug. The extract (400 mg/kg body weight per os) showed maximum inhibition of edema 64.6, 53.48, and 50.06% at the end of 3 h with carrageenan-, dextran-, and histamine-induced rat paw edema, respectively. The extract (400 mg/kg) exhibited significant reduction (34.77%) in granuloma weight in the cotton pellet-induced granuloma model. From these results it could be concluded that, the ethanol extract of Stereospermum suaveolens possesses maximum anti-inflammatory activity in a dose-dependent manner, in various experimental models.
Balasubramanian
T
T
Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. tbaluanandhi@redifmail.com
Chatterjee
Tapan Kumar
TK
Sarkar
Mahananda
M
Meena
Sundar Lal
SL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use* / Q000633:toxicity; D029402:Bignoniaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D007194:India; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D007928:Lethal Dose 50; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts