title: Expression of the retinoblastoma-related gene Rb2/p130 in the pathogenesis of serous carcinoma of the ovary.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the immunohistochemical Rb2/p130 expression in a series of benign, borderline, and malignant ovarian tumors.
  
  
  METHODS
  Seventy-six operative specimens were analyzed. Frequencies and percents were calculated for variables by each of the 5 disease stage groups in increasing severity and again for the disease stage groups collapsed into benign (serous cystadenoma or endosalpingosis), low-grade [serous borderline tumors (SBT) or low-grade serous carcinoma (LGSC)] and high-grade serous carcinoma.
  
  
  RESULTS
  There was no loss of expression in benign serous cystadenomas (0/18). Ten percent of SBT's (2/20), 47% of LGSC's (9/19), and 16% of HGSC's (3/16) had loss of expression. There was a significant difference in the expression during the progression from cystadenoma to SBT to LGSC.
  
  
  CONCLUSIONS
  Loss of Rb2/p130 expression is a rare event in benign cystadenoma. The progression to LGSC is associated with a decrease in gene expression.
authors.affiliation: Department of Obstetrics and Gynecology, New York Presbyterian Hospital-Cornell University Medical Center, New York, NY, USA. mworleyjr@gmail.com
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Worley
authors.forename: Charles N
authors.initials: CN
authors.lastname: Landen
authors.forename: Brian M
authors.initials: BM
authors.lastname: Slomovitz
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
authors.forename: Shana L
authors.initials: SL
authors.lastname: Palla
authors.forename: Pedro T
authors.initials: PT
authors.lastname: Ramirez
mesh_terms: D000117:Acetylglucosamine / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D002277:Carcinoma / Q000145:classification* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D003537:Cystadenoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D004727:Endothelium / Q000503:physiopathology; D005260:Female; D020869:Gene Expression Profiling; D018014:Gene Transfer Techniques; D005909:Glioblastoma / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006031:Glycosylation; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D037102:Lectins / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D010053:Ovary / Q000503:physiopathology; D016612:Paraffin Embedding; D010835:Phytohemagglutinins / Q000737:chemistry*; D011237:Predictive Value of Tests; D050717:Retinoblastoma-Like Protein p130 / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D014183:Transplantation, Heterologous
chemical_list: D014408:Biomarkers, Tumor; D037102:Lectins; D008562:Membrane Glycoproteins; D010835:Phytohemagglutinins; D050717:Retinoblastoma-Like Protein p130; C067494:erythroagglutinating phytohemagglutinin; D017351:N-Acetylglucosaminyltransferases; D000117:Acetylglucosamine