Encapsulation of dual cytotoxic and anti-angiogenic gold(III) complexes by gelatin-acacia microcapsules: in vitro and in vivo studies.
Encapsulation of the anticancer gold(III) complexes bearing porphyrin or Schiff-base ligands by gelatin-acacia microcapsules confers both sustained-release and rapid-release properties, improved solution stability and/or in vivo efficacy compared to that using the unencapsulated complexes alone.
Yan
Jessie Jing
JJ
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Sun
Raymond Wai-Yin
RW
Wu
Peng
P
Lin
Marie C M
MC
Chan
Albert S-C
AS
Che
Chi-Ming
CM
D000045:Acacia; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002214:Capsules; D045744:Cell Line, Tumor; D004339:Drug Compounding; D004354:Drug Screening Assays, Antitumor; D005780:Gelatin; D006801:Humans; D008665:Metalloporphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D010316:Particle Size
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D002214:Capsules; D008665:Metalloporphyrins; C508665:gold (III) porphyrin 1a; D005780:Gelatin