title: Stability studies and structural characterization of pramipexole.
abstract: Stability studies of pramipexole dihydrochloride performed under following conditions of temperature and relative humidity (RH): 25 degrees C 60% RH and 40 degrees C 75% RH revealed its tendency to the water sorption and the monohydrate formation. The structural changes occurring during storage were studied by infrared spectroscopy and X-ray powder diffraction methods. The thermogravimetry technique was used to control the water sorption by the substance. Pramipexole dihydrochloride monohydrate was characterized by nuclear magnetic resonance and X-ray single crystal diffraction methods. The monohydrate crystallizes in the orthorhombic crystal system in the space group P212121.
authors.affiliation: Pharmaceutical Research Institute, Rydygiera 8, Warsaw, Poland. m.laszcz@ifarm.waw.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Łaszcz
authors.forename: Kinga
authors.initials: K
authors.lastname: Trzcińska
authors.forename: Marek
authors.initials: M
authors.lastname: Kubiszewski
authors.forename: Bozenna
authors.initials: B
authors.lastname: Kosmacińska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Glice
mesh_terms: D000978:Antiparkinson Agents / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D004355:Drug Stability; D006860:Hydrogen Bonding; D000077487:Pramipexole; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D000077487:Pramipexole