Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma.
OBJECTIVE
The aim of this study was to investigate the expression pattern of calcium-binding proteins S100A2 and S100A4. We also sought to determine the prognostic value of these markers for patients with prostate adenocarcinoma.


METHODS
Immunohistochemical staining was performed to detect S100A2 and S100A4 expression in 26 tissue samples obtained during transurethral resection from patients with benign prostatic hyperplasia (BPH) and in 67 tissue samples obtained during prostate biopsy and radical prostatectomy from patients with prostate carcinoma. The immunoreactivity of these proteins was stratified on a scale of 0 to 3 and was correlated with the pathologic features of prostate adenocarcinoma.


RESULTS
High expression of S100A2 was observed in the tissue of patients with BPH, whereas low or no expression was observed in prostate cancer (CaP) cells. The protein level of S100A4 was significantly higher in CaP than in BPH cells. The higher level of S100A4 observed in CaP tissue correlated with increasing tumor grade.


CONCLUSIONS
Decreased expression of S100A2 and increased expression of S100A4 may be important in the progression of CaP. This finding could aid in identifying aggressive CaP. The simultaneous analysis of S100A2 and S100A4 expression in prostate tissues may be a useful prognostic marker for CaP.
Kwon
Yong-Wook
YW
Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea.
Chang
In Ho
IH
Kim
Kyung Do
KD
Kim
Young Sun
YS
Myung
Soon-Chul
SC
Kim
Mi-Kyung
MK
Kim
Tae-Hyoung
TH