title: Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: a controlled clinical pilot study.
abstract: We aimed to investigate effects of vitamins C and E (VCE) supplementation with exercise (EX) on antioxidant vitamin and lipid peroxidation (LP) levels in blood of patients with fibromyalgia (FM). A controlled study was performed on blood samples from 32 female FM patients and 30 age-matched controls. The patients were divided into three groups namely EX (n = 10), VCE (n = 11), and EX plus VCE (n = 11) after taking basal blood samples. After 12 weeks of EX and VCE supplementation, blood samples were taken once more from the patients. LP levels in plasma and erythrocytes were higher in the patients at baseline than those in controls, whereas LP levels were lower in the VCE and EX groups at the end of 12 weeks than those at baseline. Plasma concentrations of vitamins A and E and reduced glutathione were lower in the patients than those in controls and their concentrations were increased by VCE and EX. Glutathione peroxidase activity in erythrocytes was increased by VCE supplementation, with or without EX. Concentrations of β-carotene in the groups did not change with treatment. Despite the measured effects on anti-oxidative mechanisms, FM symptoms were not improved by the treatments. In conclusion, VCE with EX may protect against FM-induced oxidative stress by up-regulation of an antioxidant redox system in the plasma and erythrocytes of patients with FM. Such protective effects of VCE in the patients seemed to be greater in combination with EX than EX alone.
authors.affiliation: Department of Biophysics, Medical Faculty, Suleyman Demirel University, Isparta, Turkey. mnaziroglu@med.sdu.edu.tr
authors.forename: Mustafa
authors.initials: M
authors.lastname: Nazıroğlu
authors.forename: Selami
authors.initials: S
authors.lastname: Akkuş
authors.forename: Feray
authors.initials: F
authors.lastname: Soyupek
authors.forename: Kadir
authors.initials: K
authors.lastname: Yalman
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Çelik
authors.forename: Sevilay
authors.initials: S
authors.lastname: Eriş
authors.forename: Gökçen Ay
authors.initials: GA
authors.lastname: Uslusoy
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000502:physiology; D001205:Ascorbic Acid / Q000097:blood / Q000627:therapeutic use*; D005081:Exercise Therapy; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000188:drug therapy / Q000628:therapy*; D005978:Glutathione / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D010865:Pilot Projects; D014810:Vitamin E / Q000097:blood / Q000627:therapeutic use*; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D019207:beta Carotene; D014810:Vitamin E; D005978:Glutathione; D001205:Ascorbic Acid