Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1.
Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1 (brain-specific ether-a-go-go-like channel 1), an interaction that can result in the repression of BEC's activity and the inhibition of HIV-1 particle-release. BEC1 protein was found to be expressed in T cells and macrophages, the major target cells of HIV-1. Thus, gp120/BEC1 interaction may be involved in HIV-1 life cycle and/or pathogenesis.
Herrmann
Madeleine
M
Institute of Virology, Building 47, University of Saarland Medical School, 66421 Homburg (Saar), Germany.
Ruprecht
Klemens
K
Sauter
Marlies
M
Martinez
Javier
J
van Heteren
Pearl
P
Glas
Michael
M
Best
Barbara
B
Meyerhans
Andreas
A
Roemer
Klaus
K
Mueller-Lantzsch
Nikolaus
N
D000818:Animals; D019556:COS Cells; D002460:Cell Line; D002522:Chlorocebus aethiops; D051638:Ether-A-Go-Go Potassium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D054730:Protein Interaction Domains and Motifs; D021122:Protein Subunits; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014162:Transfection
D051638:Ether-A-Go-Go Potassium Channels; D015699:HIV Envelope Protein gp120; C121381:KCNH3 protein, human; D009419:Nerve Tissue Proteins; D021122:Protein Subunits; D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; C514793:gp120 protein, Human immunodeficiency virus 1