Quantum dots as contrast agents for in vivo tumor imaging: progress and issues.
Quantum dots (QDs) have shown promise as imaging agents in cancer, heart disease, and gene therapy research. This review focuses on the design of QDs, and modification using peptides and proteins for mediated targeting of tissues for fluorescence imaging of tumors in vivo. Recent examples from the literature are used to illustrate the potential of QDs as effective imaging agents. The distribution and ultimate fate of QDs in vivo is considered, and considerations of designs that minimize potential toxicity are presented.
Tavares
Anthony J
AJ
Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto Mississauga, ON, Canada.
Chong
Lori
L
Petryayeva
Eleonora
E
Algar
W Russ
WR
Krull
Ulrich J
UJ
D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D005453:Fluorescence; D006801:Humans; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis; D010316:Particle Size; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D045663:Quantum Dots
D003287:Contrast Media; D010455:Peptides; D011506:Proteins