title: Pyoderma gangraenosum as rare complication of incisional hernia repair in a patient with Werlhof's disease.
abstract: On the 3rd day following surgery to repair an incisional hernia, a 67-year-old male patient with Werlhof's disease (idiopathic thrombocytopenic purpura) was diagnosed with a histologically confirmed pyoderma gangraenosum (PG), a rare complication of wound healing. Dexamethasone pulse therapy resulted in rapid remission of the skin lesions. Further improvement was slowed when the patient suffered multiple organ failure in the intensive care unit, delaying his transfer to rehabilitation for 8 weeks. Postoperative PG is always a differential diagnostic possibility in patients with sterile, progressive, painful, ulcerative skin lesions at or near the surgical wound. Unlike most wound healing complications, which are treated by debridement or antibiotics, the treatment of choice for PG is high-dose steroid therapy.
authors.affiliation: Department of General Surgery, University of Wuerzburg Hospital, Oberduerrbacher Strasse 6, 97080 Wuerzbrug, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Strauss
authors.forename: J
authors.initials: J
authors.lastname: Storim
authors.forename: C-T
authors.initials: CT
authors.lastname: Germer
authors.forename: U A
authors.initials: UA
authors.lastname: Dietz
authors.forename: R
authors.initials: R
authors.lastname: Wildenauer
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D046449:Hernia, Abdominal / Q000601:surgery; D059685:Herniorrhaphy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone