title: Mortality reduction with beta-blockers in ischemic cardiomyopathy patients undergoing coronary artery bypass grafting.
abstract: Coronary artery bypass grafting (CABG) in patients with systolic heart failure (HF) carries high morbidity and mortality rates. Reducing perioperative mortality with beta-blockers (BBs) may help improve outcomes. Analysis of 4903 patients who underwent isolated CABG surgery was performed. In-hospital mortality of systolic HF patients who received BBs was 2.03%; systolic HF patients who did not receive BBs had a mortality of 5.20%. Thirty-day mortality was 2.98% in the patients with systolic HF who received BBs and 6.16% in the patients who did not. beta-Blockade did not affect the mortality in patients with preserved systolic function. Cardiogenic shock was a predictor of increased mortality in patients with systolic HF, while BBs reduced mortality. BBs are associated with decreased in-hospital and 30-day mortality in patients with systolic HF. BB therapy should be considered in patients with systolic HF who are undergoing CABG.
authors.affiliation: Stanford University Medical Center, Palo Alto, CA, USA.
authors.forename: Terence
authors.initials: T
authors.lastname: Lin
authors.forename: Nahidh W
authors.initials: NW
authors.lastname: Hasaniya
authors.forename: Susan
authors.initials: S
authors.lastname: Krider
authors.forename: Anees
authors.initials: A
authors.lastname: Razzouk
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Jun R
authors.initials: JR
authors.lastname: Chiong
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000401:mortality*; D005260:Female; D054143:Heart Failure, Systolic / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012042:Registries; D040242:Risk Reduction Behavior; D012770:Shock, Cardiogenic
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents