title: An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen.
abstract: To investigate the vascular contribution to the measured apparent diffusion coefficient and to validate the Intra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression of the vascular component and under varying echo times (TE = 50, 70, and 100 msec). The perfusion fraction f and the diffusion coefficient D were extracted from the measured DW-data using the original Intra Voxel Incoherent Motion-equation and a modified version of this equation incorporating relaxation effects. First, the perfusion fraction f in the blood suppressed pancreatic tissue decreased significantly (P = 0.03), whereas the diffusion coefficient D did not change with suppression (P = 0.43). Second, the perfusion fraction f increased significantly with increasing echo time (P = 0.0025), whereas the relaxation time compensated perfusion fraction f' showed no significant dependence on TE (P = 0.31). These results verify a vascular contribution to the diffusion weighted imaging measurement at low b values and support the Intra Voxel Incoherent Motion-theory.
authors.affiliation: Department of Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany. andreas.lemke@medma.uni-heidelberg.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Lemke
authors.forename: Frederik B
authors.initials: FB
authors.lastname: Laun
authors.forename: Dirk
authors.initials: D
authors.lastname: Simon
authors.forename: Bram
authors.initials: B
authors.lastname: Stieltjes
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Schad
mesh_terms: D000465:Algorithms; D016477:Artifacts; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009038:Motion; D010179:Pancreas / Q000098:blood supply*