title: Treatment of melasma using fractional photothermolysis: a report of eight cases with long-term follow-up.
abstract: BACKGROUND
  Melasma on the face is difficult to treat and is often refractory to multiple treatment modalities.
  
  
  OBJECTIVE
  To investigate the safety and efficacy of fractional photothermolysis (FP) for the treatment of melasma and to determine recurrence rates with this treatment method.
  
  
  METHODS
  Eight female patients (Fitzpatrick skin type II-IV) with clinically diagnosed melasma on the face were treated using FP (1,550 nm Fraxel SR laser). Two to seven treatments were performed at 3- to 8-week intervals. Treatment levels ranged from 3 to 10, corresponding to 9% to 29% surface area coverage (8-10 passes per treatment). Energies used ranged from 6 to 40 mJ. Physician and patient assessments were recorded at each visit and at a follow-up visit 7 to 36 months (mean 13.5 months) after the last treatment session.
  
  
  RESULTS
  At the last treatment, assessments revealed greater than 50% clinical improvement in melasma in five of eight patients. Follow-up assessments by the evaluating physician revealed sustained efficacy in five patients. Recurrence was reported in three patients. No significant adverse effects were noted.
  
  
  CONCLUSIONS
  FP is a safe and effective treatment for refractory melasma, with long-term remission.
authors.affiliation: Derm Surgery Associates, Houston, Texas, USA.
authors.forename: Tracy M
authors.initials: TM
authors.lastname: Katz
authors.forename: Adrienne S
authors.initials: AS
authors.lastname: Glaich
authors.forename: Leonard H
authors.initials: LH
authors.lastname: Goldberg
authors.forename: Bahar F
authors.initials: BF
authors.lastname: Firoz
authors.forename: Tianhong
authors.initials: T
authors.lastname: Dai
authors.forename: Paul M
authors.initials: PM
authors.lastname: Friedman
mesh_terms: D000328:Adult; D005145:Face; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D008548:Melanosis / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D016896:Treatment Outcome