[Cytocompatibility of PBS/PLA blend as the sternal fixation material].
To evaluate biocompatibility and cytotoxicity of PBS/PLA blend as the material for sternal fixation.


METHODS
L929 cell line was used to assess the cytotoxicity and cytocompatibility of PBS/PLA blend by incubation of the cells with the aqueous extract of the material for 3 days. The cytocompatibility of the material was evaluated by observing the proliferation of the cells cultured on the surface of the material. The proliferation of the cells cultured on the surface of the material was compared with that of the cells cultured on medical polyethylene and polyvinyl chloride to assess the cytotoxicity of the material.


RESULTS
L929 cells showed no morphological changes after a 3-day incubation with the aqueous extract of the material. The cells cultured on the surface of the blend material exhibited better proliferative activity than those cultured on medical polyethylene and polyvinyl chloride, demonstrating no obvious cytotoxicity of the material.


CONCLUSIONS
PBS/PLA blend material possesses excellent cytocompatibility and can be a promising biodegradable polymer for sternal fixation.
Hua
Kun
K
Department of Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. huakun0310@126.com
Wang
Xiao-wei
XW
Zhang
Wei
W
Zhou
Jian
J
Yang
Xiu-bin
XB
Ji
Jun-hui
JH
D000818:Animals; D001672:Biocompatible Materials; D002460:Cell Line; D002470:Cell Survival; D019344:Lactic Acid / Q000138:chemical synthesis; D008422:Materials Testing; D051379:Mice; D011108:Polymers / Q000138:chemical synthesis
D001672:Biocompatible Materials; D011108:Polymers; D019344:Lactic Acid