Colchicine myopathy and neuromyopathy: two cases with different characteristics.
Colchicine, a long established anti-inflammatory agent now used in several rheumatologic conditions, acts by inhibiting microtubular polymerization, as it binds equimolarly to tubulin molecules. Cytoskeletal microtubules are crucial in processes of cell viability, such as mitosis and intracellular vesicle motility.Gastrointestinal side effects are quite common and often minor in nature or duration, whereas neuromuscular toxicity is rare. We report 2 cases of colchicine myopathy in the context of very different clinical settings.
Cantarini
Luca
L
Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy. cantariniluca@hotmail.com
Volpi
Nila
N
Galeazzi
Mauro
M
Giani
Teresa
T
Fanti
Francesca
F
Lucherini
Orso Maria
OM
Aglianò
Margherita
M
Alessandrini
Carlo
C
Giannini
Fabio
F
Magi
Stefania
S
Greco
Giuseppe
G
Baldari
Cosima Tatiana
CT
Cimaz
Rolando
R
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000293:Adolescent; D015210:Arthritis, Gouty / Q000188:drug therapy; D003078:Colchicine / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D010505:Familial Mediterranean Fever / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced / Q000175:diagnosis; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis; D050257:Tubulin Modulators / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D050257:Tubulin Modulators; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D003078:Colchicine