title: [Acquired factor V deficiency: a rare bleeding disorder with variable clinical presentations].
abstract: Acquired anti-factor V (FV) antibodies are uncommon and the majority of reported cases are idiopathic or associated with pregnancy, malignancy, autoimmune diseases or the use of bovine thrombin preparations. Clinical presentation is highly variable, ranging from asymptomatic to life-threatening bleeding and the optimal treatment is not clearly established. We here report two patients with different clinical presentations. The first patient presented with an acute severe rectal bleeding related to acquired FV deficiency and recurrent colon cancer while the second patient was asymptomatic with a FV inhibitor detected during a routine blood testing. We discuss treatment modalities that are not consensual.
authors.affiliation: Service d'hématologie, hôpital Édouard-Herriot, 69003 Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Alcantara
authors.forename: S
authors.initials: S
authors.lastname: Ducastelle
authors.forename: L
authors.initials: L
authors.lastname: Rugeri
authors.forename: Y
authors.initials: Y
authors.lastname: Dargaud
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001803:Blood Transfusion; D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000150:complications; D048909:Diabetes Complications / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005165:Factor V / Q000276:immunology*; D005166:Factor V Deficiency / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007155:Immunologic Factors / Q000008:administration & dosage; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications; D009767:Obesity, Morbid / Q000150:complications; D035583:Rare Diseases; D012007:Rectum; D012307:Risk Factors; D012720:Severity of Illness Index; D013917:Thrombin / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D005165:Factor V; D013917:Thrombin