title: Toxicological effects of arsenate exposure on hematological, biochemical and liver transaminases activity in an Indian major carp, Catla catla.
abstract: The impact of acute and sublethal toxicity of arsenate on hematological, biochemical and enzymological parameters of an Indian major carp Catla catla were estimated. The median lethal concentration of sodium arsenate to the fish Catla catla for 96h was found to be 43.78 mg/L. During acute treatment (43.78 mg/L), hemoglobin (Hb), hematocrit (Ht), red blood cell count (RBC), white blood cell count (WBC), plasma glucose, plasma protein, liver aspartate and alanine aminotransferase (AST and ALT) levels decreased, whereas corpuscular indices like mean cell volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC) increased in arsenate treated fish. In sublethal treatment (4.378 mg/L), Hb, Ht, RBC, plasma protein levels decreased while MCHC and plasma glucose levels increased throughout the exposure period. A biphasic trend was noticed in WBC, MCV, MCH, liver AST and ALT levels. The alterations of these parameters can be effectively used as a rapid method to assess health of fish exposed to arsenate in the aquatic environment.
authors.affiliation: Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
authors.forename: Chokkalingam
authors.initials: C
authors.lastname: Kavitha
authors.forename: Annamalai
authors.initials: A
authors.lastname: Malarvizhi
authors.forename: Satyanarayanan
authors.initials: S
authors.lastname: Senthil Kumaran
authors.forename: Mathan
authors.initials: M
authors.lastname: Ramesh
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001149:Arsenates / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism; D002347:Carps / Q000502:physiology*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D012015:Reference Standards; D012996:Solutions; D000637:Transaminases / Q000378:metabolism*
chemical_list: D001149:Arsenates; D001786:Blood Glucose; D012996:Solutions; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C025657:arsenic acid