Two new lignans from the roots of Pulsatilla koreana.
Two new lignans, (2 R,3 R)-2 β-(4''-hydroxy-3''-methoxybenzyl)-3 α-(4'-hydroxy-3'-methoxybenzyl)-γ-butyrolactone 2-O-( β-D-glucopyranoside) (1) and (1 S,2 R,3 S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3',4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC (50) value of 75.9 µM, compounds 8 and 9 had moderate effects with IC (50) values of 182.2 and 166.5 µM, respectively.
Cuong
To Dao
TD
College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea.
Hung
Tran Manh
TM
Kim
Jin-Cheol
JC
Huh
Jung-Im
JI
Kwack
Seung Jun
SJ
Kang
Tae Suk
TS
Kim
Jung Hee
JH
Jang
Han Su
HS
Choi
Jae Sue
JS
Lee
Hyeong-Kyu
HK
Bae
KiHwan
K
Min
Byung Sun
BS
D005591:Chemical Fractionation; D003165:Complement System Proteins / Q000737:chemistry; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D031946:Pulsatilla / Q000737:chemistry*
C557681:(1S,2R,3S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3',4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate; C557682:(2R,3R)-2beta-(4'-hydroxy-3'-methoxybenzyl)-3alpha-(4'-hydroxy-3'-methoxybenzyl)-gamma-butyrolactone 2-O-(beta-D-glucopyranoside); D017705:Lignans; D010936:Plant Extracts; D003165:Complement System Proteins