Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population.
Mice deficiency in regulator of G-protein signaling 2(RGS2) showed an evident hypertension phenotype. Here, we studied associations of genetic variations of RGS2 with essential hypertension in the Kazakh population. Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension. A significant association was observed between 1891-1892 TC insertion/deletion with hypertension in men (OR = 1.698, P = 0.03 ) and in total population (OR = 1.32, p = 0.044) in dominant model. The mean systolic blood pressure (SBP) of the ID+DD group was significantly higher than that of the II group (adjusted, p = 0.044). Our results suggest that D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs.
Li
Nan-Fang
NF
Department of Hypertension, People's Hospital of Xinjiang Uygur, The Centre of Diagnosis, Treatment and Research of Hypertension, Urumqi, Xinjiang, Uygur, China. lnanfang@yahoo.com.cn
Zhang
Ju-Hong
JH
Yang
Jin
J
Zhou
Ling
L
Luo
Wen-Li
WL
Guo
Yan-Ying
YY
Yao
Xiao-Guang
XG
Wang
Hong-Mei
HM
Chang
Jian-Hang
JH
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020710:RGS Proteins / Q000235:genetics*; D012307:Risk Factors
D020710:RGS Proteins; C087182:RGS2 protein, human