[NiII(3-OMe-salophene)]: a potent agent with antitumor activity.
In this study, we investigated the anticancer properties of methoxy-substituted nickel(II)(salophene) derivatives. We demonstrated that the most active complex [NiII(3-OMe-salophene)] is not necrotic in Burkitt-like lymphoma cells (BJAB) and human B-cell precursor cells (Nalm-6). [NiII(3-OMe-salophene)] inhibited proliferation and induced apoptosis in a concentration dependent manner, giving evidence for the involvement of CD95 receptor-mediated, extrinsic pathway. Furthermore, [NiII(3-OMe-salophene)] overcame vincristine drug resistance in BJAB and Nalm-6 cells.
Lee
Soo-Young
SY
Department of Pediatric Oncology/Hematology, University Medical Center Charite, Berlin, Germany.
Hille
Annegret
A
Frias
Corazon
C
Kater
Benjamin
B
Bonitzki
Birgit
B
Wölfl
Stefan
S
Scheffler
Heike
H
Prokop
Aram
A
Gust
Ronald
R
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D053200:Fas-Associated Death Domain Protein / Q000096:biosynthesis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009682:Magnetic Resonance Spectroscopy; D024101:Mitochondrial Proteins / Q000096:biosynthesis; D009336:Necrosis; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014750:Vincristine / Q000494:pharmacology; D019014:fas Receptor / Q000502:physiology
D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D056831:Coordination Complexes; C412403:DIABLO protein, human; D053200:Fas-Associated Death Domain Protein; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins; D019014:fas Receptor; D014750:Vincristine