Wound healing evaluation of sodium fucidate-loaded polyvinylalcohol/sodium carboxymethylcellulose-based wound dressing.
The cross-linked hydrogel films containing sodium fucidate were previously reported to be prepared polyvinyl alcohol (PVA) and sodium carboxymethylcellulose (Na-CMC) using the freeze-thawing method and their physicochemical property was investigated. For the development of novel sodium fucidate-loaded wound dressing, here its in vivo wound healing test and histopathology were performed compared with the conventional ointment product. In wound healing test, the sodium fucidate-loaded composed of 2.5% PVA, 1.125% Na-CMC and 0.2% drug showed faster healing of the wound made in rat dorsum than the hydrogel without drug, indicating the potential healing effect of sodium fucidate. Furthermore, from the histological examination, the healing effect of sodium fucidate-loaded hydrogel was greater than that of the conventional ointment product and hydrogel without drug, since it might gave an adequate level of moisture and build up the exudates on the wound area. Thus, the sodium fucidate-loaded wound dressing composed of 5% PVA, 1.125% Na-CMC and 0.2% drug is a potential wound dressing with excellent wound healing.
Lee
Jeong Hoon
JH
Yeungnam University, Gyongsan, Korea.
Lim
Soo-Jeong
SJ
Oh
Dong Hoon
DH
Ku
Sae Kwang
SK
Li
Dong Xun
DX
Yong
Chul Soon
CS
Choi
Han-Gon
HG
D000818:Animals; D001684:Biological Dressings / Q000592:standards*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage* / Q000592:standards; D003432:Cross-Linking Reagents / Q000008:administration & dosage / Q000592:standards; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005672:Fusidic Acid / Q000008:administration & dosage* / Q000592:standards; D008297:Male; D011142:Polyvinyl Alcohol / Q000008:administration & dosage* / Q000592:standards; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D003432:Cross-Linking Reagents; D005672:Fusidic Acid; D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium