Stereological investigation of age-related changes of the capillaries in white matter.
We, for the first time, investigated the age-related changes of the capillaries in white matter using immunohistochemistry and stereological techniques. Ten young female (7 months) and 10 aged female (27 months) rats were used. The total length, total volume, and total surface area of the capillaries in white matter of aged rats were all significantly lower than those of young rats. The age-related changes of the capillaries in white matter may have important implications for age-related white matter atrophy and age-related cognitive impairments.
Shao
Wei-Hua
WH
Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Li
Chen
C
Chen
Lin
L
Qiu
Xuan
X
Zhang
Wei
W
Huang
Chun-Xia
CX
Xia
Lei
L
Kong
Ji-Ming
JM
Tang
Yong
Y
D000375:Aging; D000818:Animals; D001284:Atrophy; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply* / Q000473:pathology; D002196:Capillaries / Q000033:anatomy & histology*; D003072:Cognition Disorders / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D051381:Rats; D020318:Rats, Long-Evans