[Ischemic postconditioning of the heart. Receptor mechanisms and possibility of clinical use].
The authors of the review have analyzed papers published during last six years on the problem of ischemic postconditioning of the heart. Postconditioning has been shown to decrease infarct size, prevent apoptosis of cardiomyocytes, improve cardiac contractility in reperfusion period, prevent appearance of reperfusion arrhythmias, prevent development of no reflow phenomenon. Analyzes of published data demonstrate that adenosine, endogenous opioids, bradykinin, calcitonin gene related peptide may be triggers of postconditioning. Data on successful use of postconditioning in patients with acute myocardial infarction and cardiac surgery patients are also presented and possibility of clinical use of adenosine receptor agonists and opioids is discussed.
Lishmanov
Yu B
YB
Maslov
L N
LN
D000701:Analgesics, Opioid / Q000819:agonists; D000818:Animals; D017209:Apoptosis; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D001920:Bradykinin / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D006801:Humans; D057775:Ischemic Postconditioning; D019157:Ischemic Preconditioning, Myocardial; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000009:adverse effects; D015428:Myocardial Reperfusion Injury / Q000209:etiology; D017682:Myocardial Stunning / Q000209:etiology / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D054318:No-Reflow Phenomenon / Q000209:etiology / Q000517:prevention & control; D058906:Purinergic P1 Receptor Agonists / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
D000701:Analgesics, Opioid; D002316:Cardiotonic Agents; D058906:Purinergic P1 Receptor Agonists; D015740:Calcitonin Gene-Related Peptide; D001920:Bradykinin