title: Patient-reported side effects of intradetrusor botulinum toxin type a for idiopathic overactive bladder syndrome.
abstract: OBJECTIVE
  The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB).
  
  
  METHODS
  Botulinum toxin A injection was performed in 56 patients with idiopathic OAB. Patients were followed up for 6 months concerning side effects and patients' satisfaction.
  
  
  RESULTS
  Different types of side effects were assessed such as dry mouth (19.6%), arm weakness (8.9%), eyelid weakness (8.9%), leg weakness (7.1%), torso weakness (5.4%), impaired vision (5.4%) and dysphagia (5.4%). In all cases, symptoms were mild and transient. Urological complications such as gross hematuria (17.9%), acute urinary retention (8.9%) and acute urinary tract infection (7.1%) were noticed. In all cases, acute urinary retention was transient and treated with temporary intermittent self-catheterization. There was no statistically significant correlation between dosage and observed side effects. Patients' satisfaction rate was high (71.4%).
  
  
  CONCLUSIONS
  Intradetrusor injection of botulinum toxin was associated with a high rate of neurourological side effects. In general, side effects were transient, mild and did not require special treatment.
authors.affiliation: Department of Urology, Ludwig Maximilian University, Munich, Germany. Ricarda.Bauer@med.uni-muenchen.de
authors.forename: Ricarda M
authors.initials: RM
authors.lastname: Bauer
authors.forename: Christian
authors.initials: C
authors.lastname: Gratzke
authors.forename: Alexander
authors.initials: A
authors.lastname: Roosen
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Hocaoglu
authors.forename: Margit E
authors.initials: ME
authors.lastname: Mayer
authors.forename: Alexander
authors.initials: A
authors.lastname: Buchner
authors.forename: Christian G
authors.initials: CG
authors.lastname: Stief
authors.forename: Florian
authors.initials: F
authors.lastname: May
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A