title: [Effect of the ethanol extract of Picrorhiza scrophulariiflora on the progression of chronic kidney disease in a rat remnant kidney model].
abstract: OBJECTIVE
  To investigate the effect of the ethanol extract of Picrorhiza scrophulariiflora (EPS) on renal function and tissue damage in a rat remnant kidney model.
  
  
  METHODS
  Rat models of chronic kidney disease induced by 5/6 nephrectomy (5/6 Nx) were randomly assigned into two groups for treatment with a gavage of either EPS or vehicle for 9 weeks. The rats in the control group received only sham operation.
  
  
  RESULTS
  Compared with vehicle-treated 5/6 Nx rats, the EPS-treated rats displayed significantly decreased urinary excretion of malondialdehyde, serum levels of AGEs and AOPPs, and increased serum SeGSHPx activities. These changes were associated with attenuated urinary protein excretion, glomerular sclerosis and interstitial fibrosis.
  
  
  CONCLUSIONS
  EPS can obviously improve the renal functions and renal pathologies in rats with chronic kidney disease probably by inhibiting the oxidative stress.
authors.affiliation: Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengjx9101 @sina.com
authors.forename: Jian-xun
authors.initials: JX
authors.lastname: Feng
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Li
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Zhan-mei
authors.initials: ZM
authors.lastname: Zhou
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Tian
authors.forename: Min
authors.initials: M
authors.lastname: Liang
mesh_terms: D000818:Animals; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009392:Nephrectomy; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D032261:Picrorhiza / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000473:pathology*
chemical_list: D004365:Drugs, Chinese Herbal