title: Regional expression of the ADAMs in developing chicken cochlea.
abstract: The expression patterns of five members of the ADAM (a disintegrin and metalloprotease) family including ADAM9, ADAM10, ADAM17, ADAM22, and ADAM23 were analyzed in different anatomical structures of the developing chicken cochlea by in situ hybridization and immunohistochemistry. Results show that ADAM9, ADAM10, and ADAM17 are widely expressed in the sensory epithelium of the basilar papilla, by homogene cells, spindle-shaped cells, and acoustic ganglion cells, and in the tegmentum vasculosum, each with a different pattern. ADAM22 expression is restricted to spindle-shaped cells and acoustic ganglion cells, while ADAM23 is prominently expressed by hair cells and acoustic ganglion cells. Furthermore, ADAM10 protein is coexpressed with several members of the classic cadherins, including cadherin-7, N-cadherin, and R-cadherin in distinct anatomical regions of the cochlea except for acoustic ganglion cells. The expression of the ADAMs in the developing cochlea suggests a contribution of the ADAMs to the development of distinct cochlear structures.
authors.affiliation: Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine, University of Rostock, D-18147 Rostock, Germany.
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Annett
authors.initials: A
authors.lastname: Markus
authors.forename: Andreas
authors.initials: A
authors.lastname: Wree
authors.forename: Arndt
authors.initials: A
authors.lastname: Rolfs
authors.forename: Jiankai
authors.initials: J
authors.lastname: Luo
mesh_terms: D051722:ADAM Proteins / Q000032:analysis*; D000818:Animals; D015820:Cadherins / Q000032:analysis; D003051:Cochlea / Q000737:chemistry / Q000254:growth & development*; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D009925:Organ of Corti / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D015820:Cadherins; D051722:ADAM Proteins