Targeted imaging of flat and depressed colonic neoplasms.
Molecular imaging is a rapidly growing new discipline in gastrointestinal endoscopy that involves the development of novel imaging probes and instruments to visualize the molecular expression pattern of mucosa in the digestive tract. Several platforms for imaging agents, including antibody and peptide, are being developed to target over expressed biomolecules in cancer. In addition, novel imaging instruments, including fluorescence endoscopy and confocal microscopy, are being developed to provide wide-area surveillance and microscopic examination, respectively. These methods are being applied to detect the presence of flat and depressed colonic neoplasms and to identify tumor margins.
Wang
Thomas D
TD
Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan School of Medicine, 109 Zina Pitcher Place, BSRB 1522, Ann Arbor, MI 48109, USA. thomaswa@umich.edu
D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D055088:Early Detection of Cancer / Q000295:instrumentation / Q000379:methods; D006801:Humans; D025202:Molecular Diagnostic Techniques; D015335:Molecular Probes; D011159:Population Surveillance
D015335:Molecular Probes