Quercetin: a potential drug to reverse multidrug resistance.
This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a MDR modulator and thus a potential chemosensitizer. Finally, we contemplate future prospects of modulating MDR in the clinic.
Chen
Chen
C
Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, Shandong, 250012, PR China.
Zhou
Jane
J
Ji
Chunyan
C
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000187:drug effects; D000818:Animals; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D018528:ATP-Binding Cassette Transporters; D011794:Quercetin