[Colorectal malignancies with respect to hemocoagulation].
OBJECTIVE
Relationship between malignants tumors and damage of hemocoagulation is known. The aim is analyse this damage and evaluate the thrombotic markers. MATERIAL AND METHODICS: Authors analyses group of 137 patients with colorectal malignants tumors. They notifyes to relationship between plasmatic preoperative D dimer, PAI-1, F 1+2, Protein C level with controll group.


RESULTS
Especially aggressive forms of colorectal tumours have increased levels of D dimer and PAI-1. Protrombin fragments 1+2 were enhanced in the course of anastomotic dehiscence. Protein C level was reduced in 6.-7. decade and in advanced clinical stage.


CONCLUSIONS
Praeoperative thrombotic markers assays inform about risk of thrombosis and clinical diseases stage. They prefere mini-invasive operations procedures. The maximall validity provides D dimer and PAI-1.
Mýtnik
M
M
Chirurgická klinika FNsP Presov, Slovenská republika. mytnik@fnsppresov.sk
Kubisz
P
P
Stasko
J
J
Seliga
P
P
Dano
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis
D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; C036309:fibrin fragment D