title: Discovery of a novel Hsp90 inhibitor by fragment linking.
authors.affiliation: Evotec, Abingdon, Oxfordshire, OX14 4SA, UK.
authors.forename: John J
authors.initials: JJ
authors.lastname: Barker
authors.forename: Oliver
authors.initials: O
authors.lastname: Barker
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Courtney
authors.forename: Mihaly
authors.initials: M
authors.lastname: Gardiner
authors.forename: Thomas
authors.initials: T
authors.lastname: Hesterkamp
authors.forename: Osamu
authors.initials: O
authors.lastname: Ichihara
authors.forename: Owen
authors.initials: O
authors.lastname: Mather
authors.forename: Christian A G N
authors.initials: CA
authors.lastname: Montalbetti
authors.forename: Annett
authors.initials: A
authors.lastname: Müller
authors.forename: Mario
authors.initials: M
authors.lastname: Varasi
authors.forename: Mark
authors.initials: M
authors.lastname: Whittaker
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Yarnold
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013816:Thermodynamics
chemical_list: C555045:(4-(5-furan-2-yl-3-methyl-1H-pyrazol-4-yl)-butyl)methyl-(7H-purin-6-yl)amine; D018841:HSP90 Heat-Shock Proteins; D011720:Pyrazoles; D000225:Adenine