Nanoparticles by spray drying using innovative new technology: the Büchi nano spray dryer B-90.
Spray drying technology is widely known and used to transform liquids (solutions, emulsions, suspension, slurries, pastes or even melts) into solid powders. Its main applications are found in the food, chemical and materials industries to enhance ingredient conservation, particle properties, powder handling and storage etc. However, spray drying can also be used for specific applications in the formulation of pharmaceuticals for drug delivery (e.g. particles for pulmonary delivery). Büchi is a reference in the development of spray drying technology, notably for laboratory scale devices. This study presents the Nano Spray Dryer B-90, a revolutionary new sprayer developed by Büchi, use of which can lower the size of the produced dried particles by an order of magnitude attaining submicron sizes. In this paper, results are presented with a panel of five representative polymeric wall materials (arabic gum, whey protein, polyvinyl alcohol, modified starch, and maltodextrin) and the potentials to encapsulate nano-emulsions, or to formulate nano-crystals (e.g. from furosemide) are also shown.
Li
Xiang
X
Faculté de Pharmacie, UMR CNRS 7199 Laboratoire de Conception et Application de Molécules Bioactives, Équipe de Pharmacie Biogalénique, Université de Strasbourg, 74 route du Rhin BP 60024 F-67401 Illkirch Cedex, France. xiang.li@etu.unistra.fr
Anton
Nicolas
N
Arpagaus
Cordin
C
Belleteix
Fabrice
F
Vandamme
Thierry F
TF
D004655:Emulsions; D004867:Equipment Design; D005079:Excipients / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D044367:Phase Transition; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation* / Q000379:methods*
D004655:Emulsions; D005079:Excipients