title: Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.
abstract: We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-dependent barrier to lysogenic transfer was not observed. The emm12 strains were the only strains susceptible to the lytic action of the bacteriophage preparation.
authors.affiliation: School of Pharmacy, Microbiology Unit, University of Camerino, I-62032 Camerino, MC, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Di Luca
authors.forename: Stefania
authors.initials: S
authors.lastname: D'Ercole
authors.forename: Dezemona
authors.initials: D
authors.lastname: Petrelli
authors.forename: Manuela
authors.initials: M
authors.lastname: Prenna
authors.forename: Sandro
authors.initials: S
authors.lastname: Ripa
authors.forename: Luca A
authors.initials: LA
authors.lastname: Vitali
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology*; D008242:Lysogeny / Q000235:genetics*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000235:genetics*; D013753:Tetracycline Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004917:Erythromycin