Emerging non-transplant-based strategies in treating pediatric non-Hodgkin's lymphoma.
Lymphomas represent the third most common cancer in children and adolescents. The non-Hodgkin's lymphomas comprise a heterogeneous group of tumors, with distinct clinical and pathologic features. Although intensive multi-agent chemotherapy has made non-Hodgkin's lymphoma one of the most curable malignancies in children and young adults, there is room for improvement in treatment, particularly for those with advanced-stage disease and those who relapse after conventional therapy. New approaches are now attempting to reduce the burden of treatment, to focus on novel and more specific biologic targets, and to improve outcomes for patients with advanced-stage disease while reducing the potential for late effects. A comprehensive review of all potential agents is beyond the scope of this review, which will focus on some of the newer strategies for treating non-Hodgkin's lymphoma that are coming into clinical use today.
Gore
Lia
L
Center for Cancer and Blood Disorders, The Children's Hospital, The University of Colorado Cancer Center, Denver, 80045, USA. lia.gore@ucdenver.edu
Trippett
Tanya M
TM
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000473:pathology / Q000628:therapy; D002648:Child; D015853:Cysteine Proteinase Inhibitors / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000628:therapy; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000628:therapy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000037:antagonists & inhibitors
D000911:Antibodies, Monoclonal; D015853:Cysteine Proteinase Inhibitors; D056572:Histone Deacetylase Inhibitors; D047428:Protein Kinase Inhibitors; D053221:TNF-Related Apoptosis-Inducing Ligand; D011683:Purine-Nucleoside Phosphorylase