title: Identification of a novel class of membrane-bound [NiFe]-hydrogenases in Thermococcus onnurineus NA1 by in silico analysis.
abstract: In silico analysis of group 4 [NiFe]-hydrogenases from a hyperthermophilic archaeon, Thermococcus onnurineus NA1, revealed a novel tripartite gene cluster consisting of dehydrogenase-hydrogenase-cation/proton antiporter subunits, which may be classified as the new subgroup 4b of [NiFe]-hydrogenases-based on sequence motifs.
authors.affiliation: Marine Biotechnology Research Center, Korea Ocean Research & Development Institute, Ansan, Seoul 425-600, Republic of Korea.
authors.forename: Jae Kyu
authors.initials: JK
authors.lastname: Lim
authors.forename: Sung Gyun
authors.initials: SG
authors.lastname: Kang
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Lebedinsky
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D016000:Cluster Analysis; D040461:Gene Components; D006864:Hydrogenase / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010802:Phylogeny; D021122:Protein Subunits / Q000235:genetics; D019712:Thermococcus / Q000201:enzymology*
chemical_list: D021122:Protein Subunits; D006864:Hydrogenase