Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues.
Lgr4 is one of the genes identified as novel G protein-coupled receptor genes designated Lgr4-Lgr8, with high homology with FSH receptor, LH receptor, and TSH receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has essential functions in development. This is the first report describing the relationship between the functions of Lgr4 and female reproductive systems.
Mohri
Yasuaki
Y
Laboratory of Molecular Biology, Graduate School of Agricultrual Science, Tohoku University, Aoba-ku, Sendai, Japan.
Umezu
Tomohiro
T
Hidema
Shizu
S
Tomisawa
Hayato
H
Akamatsu
Atsushi
A
Kato
Shigeki
S
Nawa
Akihiro
A
Nishimori
Katsuhiko
K
D000818:Animals; D002970:Cleavage Stage, Ovum / Q000378:metabolism; D015536:Down-Regulation; D004622:Embryo, Mammalian; D047108:Embryonic Development / Q000235:genetics*; D004848:Epithelium / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000235:genetics* / Q000502:physiology; D007246:Infertility / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011247:Pregnancy; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism / Q000473:pathology
C496200:LGR4 protein, mouse; D043562:Receptors, G-Protein-Coupled