title: Enantioselective synthesis of SSR 241586 by using an organo-catalyzed Henry reaction.
abstract: An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).
authors.affiliation: Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Cochi
authors.forename: Thomas-Xavier
authors.initials: TX
authors.lastname: Métro
authors.forename: Domingo Gomez
authors.initials: DG
authors.lastname: Pardo
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D002384:Catalysis; D004952:Esters; D043183:Irritable Bowel Syndrome / Q000188:drug therapy*; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D004952:Esters; D009025:Morpholines; C553354:SSR 241586