title: The association between radiographic knee osteoarthritis and knee symptoms, function and quality of life 10-15 years after anterior cruciate ligament reconstruction.
abstract: BACKGROUND
  There are conflicting results in the literature regarding the association between radiographic knee osteoarthritis (OA) and symptoms and function in subjects with previous anterior cruciate ligament (ACL) reconstruction.
  
  
  OBJECTIVE
  To investigate the associations between radiographic tibiofemoral knee OA and knee pain, symptoms, function and knee-related quality of life (QOL) 10-15 years after ACL reconstruction.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  258 subjects were consecutively included at the time of ACL reconstruction and followed up prospectively. The authors included the Knee Injury and Osteoarthritis Outcome Score to evaluate knee pain, other symptoms (symptoms), activities of daily living and sport and recreation (Sport/Rec) and QOL. The subjects underwent standing radiographs 10-15 years after the ACL reconstruction. The radiographs were graded with the Kellgren and Lawrence (K&L) classification (grade 0-4).
  
  
  RESULTS
  210 subjects (81%) consented to participate in the 10-15-year follow-up. Radiographic knee OA (K&L ≥ grade 2) was detected in 71%, and 24% showed moderate or severe radiographic knee OA (K&L grades 3 and 4). No significant associations were detected between radiographic knee OA (K&L grade ≥ 2) and pain, function or QOL, respectively, but subjects with radiographic knee OA showed significantly increased symptoms. Severe radiographic knee OA (K&L grade 4) was significantly associated with more pain, symptoms, impaired Sport/Rec and reduced QOL.
  
  
  CONCLUSIONS
  Subjects with radiographic knee OA showed significantly more symptoms than those without OA, and subjects with severe radiographic knee OA had significantly more pain, impaired function and reduced quality of life than those without radiographic knee OA 10-15 years after ACL reconstruction.
authors.affiliation: Department of Orthopaedics, Norwegian research centre for Active Rehabilitation (NAR), Oslo University Hospital, Oslo, Norway. oiestad@hotmail.com
authors.forename: B E
authors.initials: BE
authors.lastname: Oiestad
authors.forename: I
authors.initials: I
authors.lastname: Holm
authors.forename: L
authors.initials: L
authors.lastname: Engebretsen
authors.forename: M A
authors.initials: MA
authors.lastname: Risberg
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction; D018771:Arthralgia / Q000209:etiology*; D001265:Athletic Injuries / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007718:Knee Injuries / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D011788:Quality of Life; D011859:Radiography; D000070600:Tibial Meniscus Injuries; D055815:Young Adult