Lactobacillus reuteri modulates cytokines production in exhaled breath condensate of children with atopic dermatitis.
We measured the concentration of interferon-gamma and interleukin-4 in the exhaled breath condensate of children with atopic and nonallergic dermatitis receiving a probiotic supplementation (Lactobacillus reuteri ATCC 55730) or placebo for 8 weeks. We demonstrated that the levels of these cytokines increased and decreased respectively only in atopic subjects receiving active treatment. Our data suggest that the oral administration of a specific probiotic strain in patients with atopic dermatitis can modulate in vivo the cytokine pattern at a different site from intestine.
Miniello
Vito Leonardo
VL
Department of Biomedicine of the Developmental Age, Pediatric Unit Salvatore Maggiore, University of Bari, Bari, Italy. vito.miniello@libero.it
Brunetti
Luigia
L
Tesse
Riccardina
R
Natile
Miria
M
Armenio
Lucio
L
Francavilla
Ruggiero
R
D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D052200:Limosilactobacillus reuteri; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*
D015847:Interleukin-4; D007371:Interferon-gamma