Design of novel RNA ligands that bind stem-bulge HIV-1 TAR RNA.
We report here the rational design and the synthesis of a new series of RNA ligands. These molecules are constituted of various binding motifs that interact cooperatively with HIV-1 TAR RNA, used as a model.
Duca
Maria
M
LCMBA UMR6001 CNRS Université de Nice Sophia Antipolis, Faculté des Sciences, Parc Valrose 06100, Nice, France.
Malnuit
Vincent
V
Barbault
Florent
F
Benhida
Rachid
R
D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry*; D015497:HIV-1 / Q000235:genetics*; D008024:Ligands; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D012367:RNA, Viral / Q000737:chemistry*; D016601:RNA-Binding Proteins / Q000737:chemistry*; D000099253:Trans-Activation Responsive RNA-Binding Protein
D006001:Glycoconjugates; D008024:Ligands; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D000099253:Trans-Activation Responsive RNA-Binding Protein