Anti-tuberculosis drug therapy in mice of different inbred strains.
Standard anti-tuberculosis (TB) drug therapy had distinct effects on the bacilli burden in mice of DBA/2, C3H, SWR/J, and C57BL/6 inbred strains. To standardize the TB infection process, susceptible DBA/2 mice were infected with 1/10 of the dose used for relatively resistant C57BL/6 mice, such that the lung CFUs were roughly identical 3 weeks after infection when therapy was initiated. We found that TB treatment was more effective in the susceptible DBA/2 mice than in the relatively resistant C57BL/6 mice.
Nikonenko
Boris V
BV
Sequella, Inc., Rockville, MD 20850, United States. borisnikonenko@sequella.com
Einck
Leo
L
Nacy
Carol A
CA
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D020022:Genetic Predisposition to Disease; D051379:Mice; D008815:Mice, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000235:genetics*
D000995:Antitubercular Agents