The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization.
This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.
Wilde
Arthur A M
AA
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Postema
Pieter G
PG
Di Diego
José M
JM
Viskin
Sami
S
Morita
Hiroshi
H
Fish
Jeffrey M
JM
Antzelevitch
Charles
C
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D053840:Brugada Syndrome / Q000503:physiopathology*; D054849:Cardiac Electrophysiology / Q000379:methods; D004562:Electrocardiography; D006801:Humans