H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China.
OBJECTIVE
The H63D polymorphism in the hemochromatosis (HFE) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) in Europe and America, but no data have been reported for Asia. Here, we investigated the possible association between H63D and sporadic ALS (sALS) in a Chinese Han population.


METHODS
A total of 195 individuals with sALS from three centers in China and 405 unrelated healthy controls were recruited. All subjects were genotyped by restriction fragment length polymorphism (RFLP) analysis.


RESULTS
Sporadic ALS was significantly related to the H63D polymorphism in heterozygous carriers (odds ratio 3.10, 95%CI: 1.49-6.47, P=0.002).


CONCLUSIONS
The HFE H63D polymorphism may contribute to the development of sALS in Chinese.
He
X
X
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Lu
X
X
Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province.
Hu
J
J
Department of Neurology, Third Hospital of Hebei Medical University, Sijiazhuang, Hebei Province, China.
Xi
J
J
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Zhou
D
D
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Shang
H
H
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Liu
L
L
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Zhou
H
H
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Yan
B
B
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Yu
L
L
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Hu
F
F
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Liu
Z
Z
Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province.
He
L
L
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
Yao
X
X
Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province.
Xu
Y
Y
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D020022:Genetic Predisposition to Disease; D005838:Genotype; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins