[Role of sigma-1 receptors in neural plasticity and in antipsychotic action].
Accumulating evidence suggests that the endoplasmic reticulum protein sigma-1 receptors function as "receptor chaperons", and that sigma-1 receptors might be involved in the pathophysiology of neuropsychiatric diseases such as schizophrenia, mood disorders, anxiety disorders, and cognitive deficits. Recent findings suggest that sigma-1 receptors play an important role in the neuronal plasticity in the brain. Recently, we reported that sigma-1 receptor agonists could enhance nerve growth factor-induced neurite outgrowth in cell culture, and that sigma-1 receptor agonists could attenuate phencyclidine-induced cognitive deficits in mice. In this article, the author reviews the role of sigma-1 receptors in the neuronal plasticity and clinical implications of sigma-1 receptors in the treatment for neuropsychiatric diseases.
Hashimoto
Kenji
K
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670 Japan. hashimoto@faculty.chiba-u.jp
D000818:Animals; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D051379:Mice; D018832:Molecular Chaperones / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D017480:Receptors, sigma / Q000502:physiology*; D000097605:Sigma-1 Receptor
D018832:Molecular Chaperones; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor