[Parathyroid hormone injection to counteract delayed bone fractures].
METHODS
Two women, aged 71 and 53 years with periprosthetic fractures of the left femur and an 18 year old man with a non-union of fracture of the left radius presented for assessment and treatment.


METHODS
Serial radiographs showed that osteosynthesis and/or autogenous bone-grafting and multiple revisions had not resulted in healing of the fractures.


METHODS
In all three patients parathyroid hormone (teriparatide), 20 to 60 microg, was injected subcutaneously once daily for 6 - 10 weeks. Subsequently a stable consolidation of the bone occurred in all of them.


CONCLUSIONS
Administration of parathyroid hormone can induce stable consolidation of the bone in non-unions and delayed healing of bone fractures.
Brunnemann
C E
CE
Klinik für Innere Medizin II, Universitätsklinikum Rostock.
Reisinger
E C
EC
Ganzer
D
D
Schober
H C
HC
D000293:Adolescent; D000368:Aged; D016025:Bone Transplantation; D004305:Dose-Response Relationship, Drug; D016267:External Fixators; D005260:Female; D005264:Femoral Fractures / Q000188:drug therapy / Q000601:surgery; D005593:Fracture Fixation, Internal; D005594:Fracture Fixation, Intramedullary; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006622:Hip Prosthesis; D006801:Humans; D007279:Injections, Subcutaneous; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000601:surgery; D011542:Pseudarthrosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D011859:Radiography; D011885:Radius Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy; D012086:Reoperation