title: Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice.
abstract: BACKGROUND
  Mulberry therapies on type 2 diabetic patients or streptozotocin-induced diabetic rats have been reported to improve fasting blood glucose levels. We investigated the effects of dietary consumption of mulberry-leaf powder and purified quercetin 3-(6-malonylglucoside), the quantitatively major flavonol glycoside in mulberry leaves, on glucose and lipid metabolism in high-fat diet-induced obese mice. Male C57BL/6J mice aged 8 weeks were assigned to three groups (control, mulberry leaf powder (MLP), and quercetin 3-(6-malonylglucoside) (Q3MG)) and treated with their respective diets for 8 weeks.
  
  
  RESULTS
  We found that dietary supplementation of 10 g MLP kg(-1) or 1 g Q3MG kg(-1) in high-fat diet effectively suppressed blood glucose levels. We also noted increased expression of glycolysis-related genes and suppression of thiobarbituric acid reactive substances concentrations in the liver of Q3MG group compared to control mice.
  
  
  CONCLUSIONS
  Dietary consumption of Q3MG, the quantitatively major flavonol glycoside in mulberry leaves, improved hyperglycemia in obese mice and reduced oxidative stress in the liver.
authors.affiliation: Shimane Institute for Industrial Technology, Matsue City, Shimane 690-0816, Japan. katsubet@icv.ne.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Katsube
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Kuninori
authors.initials: K
authors.lastname: Shiwaku
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishijima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Yukikazu
authors.initials: Y
authors.lastname: Yamasaki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage; D019587:Dietary Supplements; D005786:Gene Expression Regulation / Q000187:drug effects; D006019:Glycolysis / Q000235:genetics; D006027:Glycosides; D006943:Hyperglycemia / Q000150:complications / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D031625:Morus / Q000737:chemistry*; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D006027:Glycosides; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; C500753:quercetin 3-(6-malonylglucoside); D011794:Quercetin