[Value of endobronchial ultrasound-guided transbronchial needle aspiration in hilar and mediastinal lesions].
OBJECTIVE
To evaluate the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in cases of undiagnosed intrapulmonary lesions.


METHODS
A total of 89 patients with intrathoracic lesions underwent EBUS-TBNA, including 56 pulmonary lesions, 7 lymph node staging in lung cancer patients, 21 unknown hilar and/or mediastinal lymphadenopathies and 5 mediastinal tumors. All samples were evaluated for cytological and pathological examinations.


RESULTS
No complication of EBUS-TBNA was observed. Among 89 cases, 76 had positive results, 5 negative and 5 cases excluded as unsatisfied samples. In 56 patients with pulmonary lesions, EBUS-TBNA demonstrated 45 malignant tumors, 5 benign diseases, 3 suspicious cancers, 1 negative and 2 unsatisfied samples. In 7 lung cancer patients staged by EBUS-TBNA, 5 showed metastasis and 2 showed no metastasis. In 21 cases with mediastinal and/or hilar lymphadenopathy, EBUS-TBNA demonstrated 3 malignant tumors, 13 benign diseases, 2 negative and 3 unsatisfied samples. All 5 mediastinal lesions were malignant. Three suspicious cancers were confirmed, 1 by CT-guided percutaneous transthoracic needle biopsy and 2 by clinical follow-ups. In 2 lung cancer patients EBUS-TBNA showed negative, 1 surgical sample showed metastasis and another no metastasis by PET-CT. Three negative cases were diagnosed as benign by clinical follow-ups. The diagnostic sensitivity, specificity, positive predictive value and negative predictive value of EBUS-TBNA were 95%, 100%, 100% and 20% respectively.


CONCLUSIONS
EBUS-TBNA is both effective and safe in making a diagnosis of intrathoracic lesions.
Zhang
Lei
L
Department of Endoscopy, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China.
Cheng
Gui-yu
GY
Lü
Ning
N
Mao
You-sheng
YS
Zhang
Zhi-hui
ZH
Li
Jian
J
Li
Xiao-yan
XY
Ni
Xiao-guang
XG
Lai
Shao-qing
SQ
He
Shun
S
Yu
Gui-xiang
GX
Ju
Feng-huan
FH
Xun
Hua-ying
HY
Cheng
Rong-rong
RR
Xu
Pei-pei
PP
Wang
Gui-qi
GQ
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D001999:Bronchoscopy; D019160:Endosonography; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis; D008175:Lung Neoplasms / Q000175:diagnosis*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis; D008875:Middle Aged; D009367:Neoplasm Staging