A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.
B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.
Ligocki
A J
AJ
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lovato
L
L
Xiang
D
D
Guidry
P
P
Scheuermann
R H
RH
Willis
S N
SN
Almendinger
S
S
Racke
M K
MK
Frohman
E M
EM
Hafler
D A
DA
O'Connor
K C
KC
Monson
N L
NL
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*
D000906:Antibodies; D011947:Receptors, Antigen, B-Cell