title: Mandibular cuniculatum carcinoma: apropos of 3 cases and literature review.
abstract: BACKGROUND
  Cuniculatum carcinoma is a well-differentiated form of squamous cell carcinoma that shares histologic characteristics with papillary squamous cell carcinoma and verrucous carcinoma. Cuniculatum carcinoma usually occurs on the plantar region, and only 16 cases involving the oral cavity have been described in the literature.
  
  
  METHODS
  The authors have reported 3 cases of mandibular cuniculatum carcinoma. All of the patients were in a great deal of pain. Histologic diagnosis was difficult due to the presence of few cellular atypies. Clinical criteria, osseous lysis, and the coexistence of multiple intraosseous well-differentiated, hyperkeratotic papillomatous lesions with few cellular atypies sign the diagnosis.
  
  
  RESULTS
  No local recurrence has been reported after treatment with radical surgery alone.
  
  
  CONCLUSIONS
  The diagnosis is often delayed. Although cuniculatum carcinoma displays aggressive behavior locally, lymph node infiltration and metastasis are rare. The therapy of choice is surgical removal with free margins, after which the prognosis is excellent.
authors.affiliation: Oral and Maxillofacial Surgery Department, Assistance Publique des Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Pierre and Marie Curie University, Paris, France. pons.yoann@gmail.com
authors.forename: Yoann
authors.initials: Y
authors.lastname: Pons
authors.forename: Siham
authors.initials: S
authors.lastname: Kerrary
authors.forename: Amanda
authors.initials: A
authors.lastname: Cox
authors.forename: Agnès
authors.initials: A
authors.lastname: Guerre
authors.forename: Chloé
authors.initials: C
authors.lastname: Bertolus
authors.forename: Françoise
authors.initials: F
authors.lastname: Gruffaz
authors.forename: Frédérique
authors.initials: F
authors.lastname: Capron
authors.forename: Patrick
authors.initials: P
authors.lastname: Goudot
authors.forename: Blandine
authors.initials: B
authors.lastname: Ruhin-Poncet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed