Vesiculopustular eruption in a neonate with trisomy 21 syndrome as a clue of transient myeloproliferative disorders.
We report the case of a vesiculopustular eruption associated with a transient myeloproliferative disorder (TMD) in a neonate with trisomy 21 syndrome. Examination of a skin biopsy showed a dermal mixed inflammatory infiltrate including atypical megakaryoblasts. As the white blood cell count spontaneously normalized, the eruption disappeared. This case report and review of the literature demonstrates that a vesiculopustular eruption could be an important clue to identify TMD in a neonate.
Piersigilli
Fiammetta
F
Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.
Diociaiuti
Andrea
A
Boldrini
Renata
R
Auriti
Cinzia
C
Curci
Marco
M
El Hachem
Maya
M
Seganti
Giulio
G
D001706:Biopsy; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D055016:Megakaryocyte Progenitor Cells / Q000378:metabolism; D009196:Myeloproliferative Disorders / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology