Comparative X-ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay.
13 α,21-Dihydroeurycomanone (1), a known quassinoid of Eurycoma longifolia Jack was recrystallized from chloroform into a novel crystal structure in space group P2 (1). Its X-ray data were compared with those of eurycomanone ( 2). Following intraperioneal injections at similar doses of 2.44 µmol/kg/day for 3 consecutive days, 2 displayed comparable potency with tamoxifen but was more potent than 1 in the anti-estrogenic effect against 17 α-ethynylestradiol (EE)-induced uterotrophy of immature rats.
Teh
Chin-Hoe
CH
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Abdulghani
Mahfoudh
M
Morita
Hiroshi
H
Shiro
Motoo
M
Hussin
Abas Hj
AH
Chan
Kit-Lam
KL
D000818:Animals; D018360:Crystallography, X-Ray; D004965:Estrogen Antagonists / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000494:pharmacology; D035701:Eurycoma / Q000737:chemistry*; D005260:Female; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D036702:Quassins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013629:Tamoxifen / Q000494:pharmacology / Q000627:therapeutic use; D014599:Uterus / Q000187:drug effects
D004965:Estrogen Antagonists; D010936:Plant Extracts; D036702:Quassins; C506425:eurycomanone; D013629:Tamoxifen; D004997:Ethinyl Estradiol