Interleukin-12 as an adjuvant for induction of protective antibody responses.
Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.
Metzger
Dennis W
DW
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA. metzged@mail.amc.edu
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D018664:Interleukin-12 / Q000494:pharmacology*; D051379:Mice; D018417:Th1 Cells / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology / Q000494:pharmacology*; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D014765:Viral Vaccines; D018664:Interleukin-12