title: Human rhinoviruses in Chinese adults with acute respiratory tract infection.
abstract: OBJECTIVE
  To evaluate the roles of human rhinoviruses (HRVs) in acute respiratory tract infections (ARTIs) in Chinese adults and determine the association between species of HRV and clinical presentations.
  
  
  METHODS
  RT-PCR methods were used to detect HRVs in throat and nasal swabs collected from 6104 adult patients with ARTIs from December 2005 to April 2008 in Beijing, China.
  
  
  RESULTS
  HRV strains were detected in 271 ARTIs cases, 65% of which tested positive for HRV-A, 25% for HRV-B, and 10% for HRV-C. Aside from fever, pharyngeal congestion and headache were the most common clinical symptoms observed in the HRVs infected patients. HRV-A infected patients had a higher percentage of upper respiratory symptoms than patients infected by the two other HRV species. Systemic symptoms such as chilliness and myalgia were more frequent in people infected by HRV-B. The three HRV species exhibited unique infection timing when analyzed monthly.
  
  
  CONCLUSIONS
  HRV-C can be detected in adult patients with acute upper respiratory tract infections, but is not the predominant species in this population.
authors.affiliation: Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux and State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, 9# Dong Dan San Tiao, Dongcheng District, Beijing, PR China.
authors.forename: Zichun
authors.initials: Z
authors.lastname: Xiang
authors.forename: Richard
authors.initials: R
authors.lastname: Gonzalez
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.forename: Lan
authors.initials: L
authors.lastname: Chen
authors.forename: Taisheng
authors.initials: T
authors.lastname: Li
authors.forename: Guy
authors.initials: G
authors.lastname: Vernet
authors.forename: Gláucia
authors.initials: G
authors.lastname: Paranhos-Baccalà
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000821:virology; D010614:Pharynx / Q000821:virology; D010850:Picornaviridae Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012229:Rhinovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014773:Virology / Q000379:methods; D055815:Young Adult
chemical_list: D012367:RNA, Viral