Synthesis of N-(methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal nitric oxide synthase.
Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluated. These novel thienylmethyl-thioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
Suaifan
Ghadeer A R Y
GA
Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan. gh.suaifan@ju.edu.jo
Goodyer
Claire L M
CL
Threadgill
Michael D
MD
D006801:Humans; D007536:Isomerism; D008722:Methods; D052248:Nitric Oxide Synthase Type I / Q000187:drug effects*; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects*; D013876:Thiophenes / Q000737:chemistry; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D013876:Thiophenes; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D013890:Thiourea