title: In vitro cyclo-oxygenase expression and activity protocols: Introduction to Part I.
abstract: While the prostaglandin field may be said to have originated in the 1930s, it still remains vibrant today. Probably the main driver for this has been the growing realisation of the pathophysiological importance of the eicosanoid family, especially of their role in inflammatory and cardiovascular disease, as well as an understanding of the pharmacology of the drugs used to treat these conditions. With this has come an interest in the techniques and methodology required to study the enzymatic synthesis and metabolism of these fascinating lipids, such that this can be applied to solve the outstanding problems in the field. This introductory chapter provides a brief overview of the development of the cyclo-oxygenase field together with some introductory comments on the content of the book.
authors.affiliation: Centre for Biochemical Pharmacology, St. Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK. r.j.flower@qmul.ac.uk
authors.forename: Roderick J
authors.initials: RJ
authors.lastname: Flower
mesh_terms: D000818:Animals; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D006801:Humans; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism / Q000494:pharmacology
chemical_list: D011453:Prostaglandins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases