title: Hypopharyngeal carcinoma after radiation for tuberculosis: radiation-induced carcinoma.
abstract: Radiation may cause radiation-induced cancers after a long latency period. In a group of 111 patients surgically treated for hypopharyngeal carcinoma, patients previously treated with radiotherapy for tuberculosis in the neck were compared to patients without previous radiotherapy. Seven patients (7.4%) underwent radiotherapy (median age 15 years) and developed a hypopharyngeal carcinoma (median age 70 years, median latency period 54.4 year). Considering this long latency period and the localisation in the previous radiation field these tumours can be classified as potentially radiation-induced carcinomas. Patients with potentially radiation-induced carcinomas were significantly older when the hypopharyngeal carcinoma was diagnosed (p=0.048), were more frequently females (p=0.05) and had a worse 5-year regional control rate (p=0.048). When radiotherapy is considered in young patients the risk of induction of tumours has to be kept in mind.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Lisa
authors.initials: L
authors.lastname: van der Putten
authors.forename: Remco
authors.initials: R
authors.lastname: de Bree
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Kuik
authors.forename: Derek H F
authors.initials: DH
authors.lastname: Rietveld
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Langendijk
authors.forename: C René
authors.initials: CR
authors.lastname: Leemans
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000209:etiology / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D008297:Male; D009333:Neck; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D013997:Time Factors; D014376:Tuberculosis / Q000532:radiotherapy*; D055815:Young Adult