Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.
Alzheimer's disease is a progressive neurodegenerative disorder, either assuming a sporadic, age-associated, late-onset form, or a familial form, with early onset, in a smaller fraction of the cases. Whereas in the familial cases several mutations have been identified in genes encoding proteins related with the pathogenesis of the disease, for the sporadic form several causes have been proposed and are currently under debate. Mitochondrial dysfunction has surfaced as one of the most discussed hypotheses acting as a trigger for the pathogenesis of Alzheimer's disease. Mitochondria assume central functions in the cell, including ATP production, calcium homeostasis, reactive oxygen species generation, and apoptotic signaling. Although their role as the cause of the disease may be controversial, there is no doubt that mitochondrial dysfunction, abnormal mitochondrial dynamics and degradation by mitophagy occur during the disease process, contributing to its onset and progression.
Santos
Renato X
RX
Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal.
Correia
Sónia C
SC
Wang
Xinglong
X
Perry
George
G
Smith
Mark A
MA
Moreira
Paula I
PI
Zhu
Xiongwei
X
D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction