Moonshine illuminates a developmental role for regulated transcription elongation.
Mutations in the zebrafish gene moonshine, encoding the ortholog of TIF1 gamma, cause profound anemia and embryonic lethality. In a recent issue of Cell, Bai et al. provide evidence that these defects arise from inefficient transcription elongation, implicating elongation as an important point of regulation during cell differentiation and development.
Gilchrist
Daniel A
DA
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Adelman
Karen
K