title: Synthesis and preliminary evaluation of the antimicrobial activity of selected 3-benzofurancarboxylic acid derivatives.
abstract: Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. (1)H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts. Three compounds, III, IV, and VI, showed antimicrobial activity against Gram-positive bacteria (MIC 50 to 200 microg/mL). Compounds VI and III exhibited antifungal activity against the Candida strains C. albicans and C. parapsilosis (MIC-100 microg/mL).
authors.affiliation: Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland. jerzy.kossakowski@wum.edu.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Mariola
authors.initials: M
authors.lastname: Krawiecka
authors.forename: Bozena
authors.initials: B
authors.lastname: Kuran
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefańska
authors.forename: Irena
authors.initials: I
authors.lastname: Wolska
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D054879:Halogenation; D008826:Microbial Sensitivity Tests
chemical_list: C510597:3-benzo(b)furan carboxylic acid; D000890:Anti-Infective Agents; D001572:Benzofurans; D002264:Carboxylic Acids