Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins.
Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.
Seck
Tetsu M
TM
Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, D-55099 Mainz, Germany; MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Melchels
Ferry P W
FPW
MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Feijen
Jan
J
MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Grijpma
Dirk W
DW
MIRA Institute for Biomedical Technology and Technical Medicine, and Department of Biomaterials Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands; Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands. Electronic address: d.w.grijpma@utwente.nl.
D001673:Biodegradation, Environmental; D002448:Cell Adhesion; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D059630:Mesenchymal Stem Cells; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*
D011091:Polyesters; D012117:Resins, Synthetic; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C033616:poly(lactide)