Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model.
Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.
Peterson
Richard A
RA
Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. richard.a.peterson@gsk.com
Krull
David L
DL
Brown
H Roger
HR
de Serres
Mark
M
D000818:Animals; D001648:Bile Canaliculi / Q000473:pathology; D049109:Cell Proliferation; D002675:Child, Preschool; D005234:Fatty Liver / Q000473:pathology; D022781:Hepatocytes / Q000473:pathology / Q000637:transplantation*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D055806:Microvessels / Q000473:pathology; D018183:Transplantation Chimera; D014183:Transplantation, Heterologous; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics / Q000378:metabolism*
D014568:Urokinase-Type Plasminogen Activator