title: In vivo biocompatibility assessment of (PTFE-PVDF-PP) terpolymer-based membrane with potential application for glaucoma treatment.
abstract: The aim of the work was to evaluate the in vivo biological behaviour of polymeric membrane materials for glaucoma implants. The base material was biostable synthetic terpolymer (PTFE-PVDF-PP) with proved biocompability (PN-EN ISO 10993). The samples manufactured in the form a membrane were subjected to chemical and physical treatment to create an open pore system within the polymer matrix. As a porogenic phase biodegradable natrium alginate in a fibrous form was employed. The non-perforating deep sclerectomy technique was performed in a rabbit model. The clinical observations were made after 14 and 30 days. During the study clinical symptoms of a moderate degree were observed, and histopathological changes were typical for foreign body implantation. At the end stage of the study no significant difference in histopathological assessment was found between control and experimental group. Similarities observed in both groups and relatively mild histopathological changes in the tissue surrounding the implant indicate that the observed symptoms come from a deep scleral trauma caused by surgery, and not by the presence of the implant itself.
authors.affiliation: Department of Ophthalmology, Medical University of Silesia, Katowice, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Leszczynski
authors.forename: Ewa
authors.initials: E
authors.lastname: Stodolak
authors.forename: Jarosław
authors.initials: J
authors.lastname: Wieczorek
authors.forename: Jolanta
authors.initials: J
authors.lastname: Orlowska-Heitzman
authors.forename: Teresa
authors.initials: T
authors.lastname: Gumula
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Blazewicz
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D005901:Glaucoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D023421:Models, Animal; D011138:Polytetrafluoroethylene / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D019736:Prostheses and Implants; D011817:Rabbits; D012590:Sclera / Q000473:pathology / Q000601:surgery; D012599:Sclerostomy / Q000379:methods; D005465:Fluorocarbon Polymers
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D011145:Polyvinyls; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers