Reciprocal modulation between TH17 and other helper T cell lineages.
T helper 17 (TH17) cells have well-described roles in autoimmune disease. However, TH17 is not stable in some physiological or pathological courses. Also, TH17 cells can reciprocally modulate and convert into other helper T cell subpopulations. The fully exploring the reciprocal regulatory effects and its immunoregulatory mechanisms are becoming interesting topics in the immunological study. In this review, we summarized reciprocal modulation pattern between TH17 cell and other helper T cell subpopulations in the mouse model of autoimmune diseases and human diseases.
Bi
Yujing
Y
State Key Laboratory of Pathogen and Biosecurity, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences (AMMS), Beijing, China.
Liu
Guangwei
G
Yang
Ruifu
R
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000145:classification* / Q000276:immunology / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification* / Q000276:immunology / Q000502:physiology*; D058504:Th17 Cells / Q000276:immunology / Q000502:physiology*
D016207:Cytokines