title: eGFR is associated with subclinical atherosclerosis independent of albuminuria: the Dong-gu Study.
abstract: OBJECTIVE
  This study evaluated the relationships between estimated glomerular filtration rate (eGFR) and carotid atherosclerosis, peripheral arterial disease (PAD), arterial stiffness, and left ventricular hypertrophy, independent of albuminuria.
  
  
  METHODS
  The study population consisted of 6694 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2009. The common carotid artery intima-media thickness (CCA-IMT), carotid plaque, ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and left ventricular mass index (LVMI) of each subjects was assessed.
  
  
  RESULTS
  After adjustment for risk factors and albumin-creatinine ratio (ACR), kidney dysfunction (eGFR=30-44 ml/min per 1.73 m2) was significantly associated with carotid plaque presence (odds ratio [OR], 1.75; 95% confidence interval [CI], 1.21-2.53) and PAD (OR, 2.64; 95% CI, 1.51-4.62) compared to normal kidney function (eGFR≥60 ml/min per 1.73 m2). Similarly, mean LVMI and baPWV differed significantly according to eGFR after adjustment for other risk factors and ACR; in contrast, no significant difference was observed for CCA-IMT.
  
  
  CONCLUSIONS
  Independent of albuminuria, eGFR is associated with carotid plaque, PAD, baPWV, and LVMI but not with CCA-IMT in Koreans aged 50 years and older.
authors.affiliation: Department of Overseas Hospital Consulting, Korea Health Industry Development Institute, 57-1, Norayngjin-dong, Dongjak-gu, Seoul 156-800, Republic of Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.forename: Hye-Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Ryu
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000175:diagnosis*; D050197:Atherosclerosis / Q000150:complications* / Q000175:diagnosis*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D004452:Echocardiography / Q000379:methods; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007723:Korea; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000473:pathology; D012307:Risk Factors; D014463:Ultrasonography / Q000379:methods