[Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC].
OBJECTIVE
An HPLC method was developed to determinate Ibuprofen and Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate in Compound BuluoWeimaNamin Tablets.


METHODS
Using HPLC with Kromasil C18 column, and acetonitrile -0.5% SDS- phosphate (580:420:1) as the mobile phase. The wavelength for detection was 262 nm.


RESULTS
Better linearities and good correlation coefficients were obtained: the concentration ranges of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were over 2.062-14.434 microg (r=0.9999), 0.296-2.072l microg (r=0.9999), and 0.0204~0.1428 microg (r=0.9998), respectively. The recoveries of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were 99.98% (RSD=0.52%), 99.72 (RSD=0.82%) and 99.545 (RSD=0.76%), respectively.


CONCLUSIONS
The method was convenient, accurate and specific. It can be used as a method to control quality of Compound Buluoweimanamin Tablets.
Yin
San-fu
SF
Chongqing Medical University College of Pharmacy, Chongqing 400016, China. ysf906@163.com
Qiu
Zong-yin
ZY
D002744:Chlorpheniramine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007052:Ibuprofen / Q000032:analysis*; D054199:Pseudoephedrine / Q000032:analysis*; D013607:Tablets / Q000737:chemistry
D013607:Tablets; D002744:Chlorpheniramine; D054199:Pseudoephedrine; D007052:Ibuprofen