On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory.
In this retrospective, we recall some select cases of synergy between very challenging chemical synthesis and the identification of promising new candidates for pharmaceutics development. The progression from targets, often referred to as small molecules, to those of a size commonly associated with biologics (including glycoproteins) is also charted.
Wilson
Rebecca M
RM
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.
Danishefsky
Samuel J
SJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D055808:Drug Discovery; D007753:Laboratories; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D001688:Biological Products; D002241:Carbohydrates