title: [Quantitative MR-Spectroscopy: implementation and quality assurance on a clinical MR-scanner].
abstract: The aim of this study was the implementation of quantitative MR-Spectroscopy with external reference signals on a Philips Gyroscan Intera 1,5 T MR-Scanner for routine clinical use. We established measurements for quality assurance of the used phantoms and methods. In detail we analyzed the dependence of the signal on concentration and volume as well as on the local variation within the coil and the impact of these factors on quantification. Furthermore we established measurements for routine constancy checks. The method as well as the software for concentration calculation was checked by an in vitro measurement. In a blinded measurement the concentrations of NAA, Cho and Kr in the PTB reference phantom 10614mM were determined correctly within their error limits.
authors.affiliation: Abteilung Medizinische Physik in der Radiologie, DKFZ Heidelberg. micheal.reinert@klinikum-fulda.de
authors.forename: Michael
authors.initials: M
authors.lastname: Reinert
authors.forename: Peter
authors.initials: P
authors.lastname: Schneider
authors.forename: Erich
authors.initials: E
authors.lastname: Hofmann
authors.forename: Wolfhard
authors.initials: W
authors.lastname: Semmler
mesh_terms: D001921:Brain / Q000502:physiology*; D004867:Equipment Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D019047:Phantoms, Imaging; D011786:Quality Control; D015203:Reproducibility of Results; D015398:Signal Transduction; D012984:Software