title: Beta3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects.
abstract: We determined whether ADRbeta3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).
authors.affiliation: Laboratório de Fisiopatologia Clínica e Experimental (CLINEX), Clínica de Hipertensão, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: V A
authors.initials: VA
authors.lastname: Genelhu
authors.forename: E A
authors.initials: EA
authors.lastname: Francischetti
authors.forename: S F P
authors.initials: SF
authors.lastname: Duarte
authors.forename: B M J
authors.initials: BM
authors.lastname: Celoria
authors.forename: R C
authors.initials: RC
authors.lastname: Oliveira
authors.forename: P H
authors.initials: PH
authors.lastname: Cabello
authors.forename: M M G
authors.initials: MM
authors.lastname: Pimentel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics; D001938:Brazil; D002318:Cardiovascular Diseases / Q000150:complications* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D022702:Receptors, Adrenergic, beta-3