Homomeric protein complexes: evolution and assembly.
Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their assembly in solution.
Venkatakrishnan
A J
AJ
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Levy
Emmanuel D
ED
Teichmann
Sarah A
SA
D000818:Animals; D019418:Evolution, Chemical; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D025941:Protein Interaction Mapping; D055503:Protein Multimerization / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*
D046912:Multiprotein Complexes; D011506:Proteins