[Neurovascular intervention in the acute phase of cerebral infarction].
OBJECTIVE
Endovascular therapies in acute ischaemic stroke may offer benefits to patients that are not eligible for standard use of intravenous tissue activator plasminogen (iv t-PA) or when this is not effective. Our aim is to present the initial experience in with endovascular techniques in the Community of Madrid.


METHODS
We present data from our registry of acute ischaemic strokes treated with endovascular re-perfusion therapies in five University Hospitals in Madrid (Spain) during the period 2005-2009. We recorded demographic data, vascular risk factors, risk severity with the NIHSS (National Institute of Health Stroke Scale), endovascular techniques, complications and mortality rates. Functional outcome and neurological disability at 90 days was defined by the modified Rankin scale (mRs).


RESULTS
A total of 41 patients were treated with endovascular therapies. Mean age was 58.6 ± 19.9, and 56.1% were males. Of those 22 patients had an anterior circulation stroke and 19 had a posterior circulation stroke. Baseline NIHSS score was: median, 17 [range, 2-34]; 7 patients had previously received iv t-PA. The following endovascular techniques were performed: mechanical disruption (26 patients), intra-arterial infusion of t-PA (26 patients), angioplasty and stenting (5 patients), mechanical use of MERCI device (3 patients). Partial or total re-canalization was achieved in 32 patients (78%). Only one patient had a symptomatic cerebral haemorrhage. Three months after stroke, 53.6% of the patients were independent (mRs ≤ 2) and overall mortality rate was 19.5%.


CONCLUSIONS
Acute ischaemic stroke is a potentially treatable medical emergency within the first hours after the onset of symptoms. Stroke endovascular procedures constitute an alternative for patients with iv t-PA exclusion criteria or when this is not effective.
Cruz Culebras
A
A
Unidad de Ictus, Servicio de Neurología, Hospital Universitario Ramón y Cajal, Madrid, España.
García-Pastor
A
A
Reig
G
G
Fuentes
B
B
Simal
P
P
Méndez-Cendón
J C
JC
Caniego
J L
JL
Castro
E
E
Frutos
R
R
Gil
A
A
Vivancos
J
J
Gil-Núñez
A
A
Díez-Tejedor
E
E
Egido
J A
JA
Alonso de Leciñana
M
M
Masjuan
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002560:Cerebrovascular Circulation; D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D015424:Reperfusion / Q000379:methods; D013030:Spain; D020521:Stroke / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome