title: [Importance of biologic parameters in Helicobacter pylori gastritis: comparison with histological results].
abstract: Helicobacter pylori (HP) chronic gastritis can lead to precursor stages of gastric cancer. New biological markers have been proposed to study the gastric mucosal state. We evaluate biological results in comparison with histological ones in a dyspeptic population. Forty nine dyspeptic patients underwent endoscopy with gastric biopsies for histological examination. Blood samples were obtained to measure levels of gastrin 17 (G17), pepsinogen 1 (PG1), pepsinogen 2 (PG2) and the rate of anti-HP IgG antibodies. Four patients have a healthy gastric mucosa and 45 have a gastritis (32 have a nonatrophic gastritis and 13 an atrophic one). An increase in the level of PG2 and a decrease of the PG1/PG2 ratio were noticed in the group of subjects with a nonatrophic gastritis compared to the healthy mucosa group. The decrease of the PG1/PG2 ratio was more important in the corpus atrophic gastritis group than in the antrum restricted atrophic gastritis one. In conclusion, in front of dyspeptic patients, we advice to practice in first intention the measurement of the serological level of G17, PG1, PG2 and anti-HP IgG antibodies.
authors.affiliation: Service de biologie clinique, Institut Salah Azaïz, Tunis, Tunisia. abazahajera@yahoo.fr
authors.forename: Hajer
authors.initials: H
authors.lastname: Abaza
authors.forename: Abderraouf
authors.initials: A
authors.lastname: Ghanem
authors.forename: Jeannette
authors.initials: J
authors.lastname: Karoui
authors.forename: Aouatef
authors.initials: A
authors.lastname: Jmal
authors.forename: Rabiaa
authors.initials: R
authors.lastname: Dhouib
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.forename: Nabyl
authors.initials: N
authors.lastname: Ben Mami
authors.forename: Rahal
authors.initials: R
authors.lastname: Khaled
authors.forename: Fethi
authors.initials: F
authors.lastname: Guemira
mesh_terms: D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D004415:Dyspepsia / Q000097:blood / Q000382:microbiology; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood / Q000473:pathology; D016481:Helicobacter Infections / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D020116:Pepsinogen A / Q000097:blood
chemical_list: D015415:Biomarkers; D005755:Gastrins; D007074:Immunoglobulin G; D020116:Pepsinogen A