Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.
Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.
Jansen
Janine
J
MIRA Institute for Biomedical Technology and Technical Medicine and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Boerakker
Mark J
MJ
Heuts
Jean
J
Feijen
Jan
J
Grijpma
Dirk W
DW
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005650:Fumarates / Q000138:chemical synthesis* / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D008970:Molecular Weight; D041681:NIH 3T3 Cells; D055668:Photochemical Processes; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry; D012995:Solubility; D014753:Vinyl Compounds / Q000737:chemistry; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000494:pharmacology
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D004146:Dioxanes; D004337:Drug Carriers; D005650:Fumarates; D011108:Polymers; D011760:Pyrrolidinones; D014753:Vinyl Compounds; C059299:polytrimethylene carbonate; C042670:N-vinyl-2-pyrrolidinone; C011566:vinyl acetate; D014805:Vitamin B 12; C061175:ethyl fumarate