Mandibular cuniculatum carcinoma: apropos of 3 cases and literature review.
BACKGROUND
Cuniculatum carcinoma is a well-differentiated form of squamous cell carcinoma that shares histologic characteristics with papillary squamous cell carcinoma and verrucous carcinoma. Cuniculatum carcinoma usually occurs on the plantar region, and only 16 cases involving the oral cavity have been described in the literature.


METHODS
The authors have reported 3 cases of mandibular cuniculatum carcinoma. All of the patients were in a great deal of pain. Histologic diagnosis was difficult due to the presence of few cellular atypies. Clinical criteria, osseous lysis, and the coexistence of multiple intraosseous well-differentiated, hyperkeratotic papillomatous lesions with few cellular atypies sign the diagnosis.


RESULTS
No local recurrence has been reported after treatment with radical surgery alone.


CONCLUSIONS
The diagnosis is often delayed. Although cuniculatum carcinoma displays aggressive behavior locally, lymph node infiltration and metastasis are rare. The therapy of choice is surgical removal with free margins, after which the prognosis is excellent.
Pons
Yoann
Y
Oral and Maxillofacial Surgery Department, Assistance Publique des Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Pierre and Marie Curie University, Paris, France. pons.yoann@gmail.com
Kerrary
Siham
S
Cox
Amanda
A
Guerre
Agnès
A
Bertolus
Chloé
C
Gruffaz
Françoise
F
Capron
Frédérique
F
Goudot
Patrick
P
Ruhin-Poncet
Blandine
B
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed