[Progress in the methods of ocular pharmacokinetics].
Pharmacokinetics can help us to understand the metabolic feature of drugs and it also can instruct the dosage, interval, route and form of drugs used in clinic, guarantee the curative effects and reduce the side effects and toxicity. With the wide range of applications, high sensitivity and specificity, chromatography and immunoassay have been the common methods used in pharmacokinetic study, but the results are one-dimensional, operation is complicated and there are more interference factors. Imaging examination and Raman spectroscopy can be carried out in the ocular pharmacokinetic research non-invasively and continuously in vivo, but only for some specific drug testing. Subject to the restrictions of the devices themselves, specificity and sensitivity are somewhat less. Therefore, it is necessary to chose a suitable method taking into account the drug delivery methods, drug target tissue, drug metabolism characteristics of the selection of suitable methods, or combine with several methods as complementary and validation. In addition, a variety of pharmacokinetic models can also well describe, explain and predict the metabolism of drugs in eyes.
Guo
Hui-ling
HL
Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
Huang
Yi-fei
YF
D004333:Drug Administration Routes; D015195:Drug Design; D005123:Eye / Q000378:metabolism*; D010599:Pharmacokinetics