title: High-resolution coronary imaging by optical coherence tomography: Feasibility, pitfalls and artefact analysis.
abstract: BACKGROUND
  Optical coherence tomography is an imaging method that enables cardiologists to study atheromatous plaques, and to check the implantation and evolution of coronary stents. It is an invasive technique, providing high-resolution (10 microm) in vivo images, but with limitations and artefacts that need to be understood before the field of application can be extended.
  
  
  OBJECTIVE
  To determine the feasibility and limitations of optical coherence tomography coronary imaging from a single-centre experience.
  
  
  METHODS
  We analysed the first 301 optical coherence tomography (version M2, LightLab Imaging) sequences obtained in our department from examination of 73 patients.
  
  
  RESULTS
  Results showed that 92% of sequences for selected lesions were usable, with a mean examination time of 17 min. Only one complication occurred (ventricular fibrillation, reduced by external electroshock). In our registry, sequence quality depended on operator experience (improving after 20 examinations), and was impaired by artefacts, especially in right coronary analysis and in arteries of greater than 3.5 mm calibre.
  
  
  CONCLUSIONS
  Proximal coronary occlusion and the distal flush quality currently required for quality imaging should no longer be indispensable with the new generation of optical coherence tomography systems.
authors.affiliation: Department of Cardiology, Gabriel-Montpied Hospital, CHU Clermont-Ferrand, 63003 Clermont-Ferrand, France. pmotreff@chu-clermontferrand.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Motreff
authors.forename: Sébastien
authors.initials: S
authors.lastname: Levesque
authors.forename: Géraud
authors.initials: G
authors.lastname: Souteyrand
authors.forename: Laurent
authors.initials: L
authors.lastname: Sarry
authors.forename: Lemlih
authors.initials: L
authors.lastname: Ouchchane
authors.forename: Bernard
authors.initials: B
authors.lastname: Citron
authors.forename: Jean
authors.initials: J
authors.lastname: Cassagnes
authors.forename: Jean-René
authors.initials: JR
authors.lastname: Lusson
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D016477:Artifacts; D002983:Clinical Competence; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D005602:France; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012042:Registries; D015607:Stents; D041623:Tomography, Optical Coherence / Q000009:adverse effects; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional