title: Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population.
abstract: Mice deficiency in regulator of G-protein signaling 2(RGS2) showed an evident hypertension phenotype. Here, we studied associations of genetic variations of RGS2 with essential hypertension in the Kazakh population. Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension. A significant association was observed between 1891-1892 TC insertion/deletion with hypertension in men (OR = 1.698, P = 0.03 ) and in total population (OR = 1.32, p = 0.044) in dominant model. The mean systolic blood pressure (SBP) of the ID+DD group was significantly higher than that of the II group (adjusted, p = 0.044). Our results suggest that D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs.
authors.affiliation: Department of Hypertension, People's Hospital of Xinjiang Uygur, The Centre of Diagnosis, Treatment and Research of Hypertension, Urumqi, Xinjiang, Uygur, China. lnanfang@yahoo.com.cn
authors.forename: Nan-Fang
authors.initials: NF
authors.lastname: Li
authors.forename: Ju-Hong
authors.initials: JH
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Luo
authors.forename: Yan-Ying
authors.initials: YY
authors.lastname: Guo
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Yao
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Jian-Hang
authors.initials: JH
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020710:RGS Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D020710:RGS Proteins; C087182:RGS2 protein, human