Glutamic acid decarboxylase antibody-positive paraneoplastic stiff limb syndrome associated with carcinoma of the breast.
Stiff limb syndrome (SLS) is a rare "focal" variant of stiff person syndrome which presents with rigidity and painful spasms of a distal limb, and abnormal fixed foot or hand postures. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) are variably present in most cases. Most reported cases of SLS are unassociated with cancer. We describe a patient with SLS as a paraneoplastic manifestation of breast carcinoma, in whom GAD-Ab was present. The patient responded very well to oral diazepam, baclofen and steroids.This is the third reported case of SLS as a paraneoplastic accompaniment to cancer.
Agarwal
Pankaj A
PA
Department of Neurology, Aditya Birla Memorial Hospital, Pune, Maharashtra, India. drpankaj.agarwal@rediffmail.com
Ichaporia
Nasli R
NR
D001943:Breast Neoplasms / Q000150:complications / Q000276:immunology; D002277:Carcinoma / Q000150:complications / Q000276:immunology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000150:complications; D016750:Stiff-Person Syndrome / Q000150:complications / Q000276:immunology
D007136:Immunoglobulins; D005968:Glutamate Decarboxylase