Basaloid follicular hamartoma.
Basaloid follicular hamartoma is a benign lesion of important consideration because it can be mistaken both clinically and histologically for basal cell carcinoma. The formation of basaloid follicular hamartoma has been linked to a mutation in the patched gene, which is part of the same pathway implicated in nevoid basal cell carcinoma syndrome. While these hamartomas are considered benign lesions, malignant growths have been reported to arise within them, which raises the question, "Is basaloid follicular hamartoma a premalignant lesion?" Correct identification allows for periodic monitoring for malignant transformation, while sparing patients unnecessary surgery. Treatment strategies, including experimental therapies, are reviewed.
Mills
Omie
O
Department of Pathology and Cell Biology, University of South Florida, Palmetto, FL 34221, USA. omills@health.usf.edu
Thomas
L Brannon
LB
D002280:Basal Cell Carcinoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D006201:Hair Diseases / Q000175:diagnosis* / Q000235:genetics; D018859:Hair Follicle / Q000473:pathology*; D006222:Hamartoma / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D009154:Mutation; D000072079:Patched Receptors; D011956:Receptors, Cell Surface / Q000235:genetics; D012878:Skin Neoplasms / Q000175:diagnosis
D000072079:Patched Receptors; D011956:Receptors, Cell Surface