title: Two new species of Mucor from clinical samples.
abstract: Two new species in the order Mucorales, Mucor velutinosus and Mucor ellipsoideus, isolated from human clinical specimens in the USA, are described and illustrated. The former species is similar to Mucor ramosissimus, from which it can be differentiated by its ability to grow at 37°C and produce verrucose sporangiospores. Mucor ellipsoideus is also able to grow and sporulate at 37°C like M. indicus, the nearest phylogenetic species in this study, however, the former has narrow ellipsoidal sporangiospores in contrast to the subglobose to ellipsoidal sporangiospores of M. indicus. Analysis of the sequences of the ITS and the D1-D2 regions of the rRNA genes confirmed the novelty of these species. The in vitro antifungal susceptibility of the new species showed that amphotericin B was active against all isolates and posaconazole and itraconazole showed low activity.
authors.affiliation: Mycology Unit, Medical School, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Alvarez
authors.forename: Josep
authors.initials: J
authors.lastname: Cano
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Stchigel
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Valentina
authors.initials: V
authors.lastname: Salas
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009090:Mucorales / Q000145:classification* / Q000254:growth & development / Q000302:isolation & purification*; D009091:Mucormycosis / Q000175:diagnosis* / Q000382:microbiology*; D016533:Mycological Typing Techniques; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013696:Temperature; D014230:Triazoles / Q000494:pharmacology; D014481:United States
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000666:Amphotericin B