[Hydrogen magnetic resonance quantitative spectroscopy at 3 T in symptomatic and asymptomatic Huntington's disease patients].
BACKGROUND
Huntington's disease is an hereditary autosomic-dominant neurodegenerative disorder, characterized by motor, cognitive and psychiatric symptoms.


OBJECTIVE
To quantify differences in N-acetylaspartate, creatine and choline in caudate nucleus, putamen and occipital cortex of patients with Huntington's disease, symptomatics and asymptomatics.


METHODS
Hydrogen magnetic resonance spectroscopy was performed with a 3 T scanner in 10 Huntington's disease gene-tested subjects, included in three groups: negative (control), positive symptomatics and positive asymptomatics. Data was quantified with LCModel and analyzed with ANOVA and Fisher tests.


RESULTS
Symptomatic patients showed decreased creatine and N-acetylaspartate in the three regions, and decreased choline only in putamen (p < 0.05). Choline difference was found between symptomatics and asymptomatics in the caudate nucleus (p < 0.05).


CONCLUSIONS
Results may reflect neuronal dysfunction and suggest that creatine and choline may serve as markers for Huntington's disease progression.
Alcauter-Solórzano
Sarael
S
Posgrado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Querétaro, QRO, México.
Pasaye-Alcaraz
Erick H
EH
Alvarado-Alanis
Patricia
P
Fermín-Delgado
Rafael O
RO
Alonso-Vilatela
M Elisa
ME
Salgado-Lujambio
Perla
P
Barrios
Fernando A
FA
D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000378:metabolism; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
D006859:Hydrogen