title: Vitamin C increases the fecal fat excretion by chitosan in guinea-pigs, thereby reducing body weight gain.
abstract: The aims of this study were to investigate the antiobesity properties of chitosan on its own, as well as in the presence of vitamin C, in vivo. Hartley guinea-pigs were divided into Control (normal diet), F-control (high fat diet), Chitosan (high fat diet with 5.0% chitosan) and Chito-vit C (high fat diet with 5.0% chitosan containing 0.5% vitamin C) groups, respectively. The effects of chitosan, both alone and in the presence of vitamin C, on body weight, total fecal weight, fecal composition and plasma lipid level were studied for 5 weeks. The results of this study indicated that the fat-binding and water-holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion. Vitamin C increased the fecal fat excretion by chitosan in guinea-pigs, thereby reducing body weight gain.
authors.affiliation: Department of Food and Nutrition, Dongduk Women's University, Seoul 136-714, Korea.
authors.forename: S C
authors.initials: SC
authors.lastname: Jun
authors.forename: E Y
authors.initials: EY
authors.lastname: Jung
authors.forename: D H
authors.initials: DH
authors.lastname: Kang
authors.forename: J M
authors.initials: JM
authors.lastname: Kim
authors.forename: U J
authors.initials: UJ
authors.lastname: Chang
authors.forename: H J
authors.initials: HJ
authors.lastname: Suh
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001786:Blood Glucose; D048271:Chitosan / Q000494:pharmacology*; D004032:Diet; D005223:Fats / Q000032:analysis; D005243:Feces / Q000737:chemistry*; D006168:Guinea Pigs; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D005223:Fats; D008055:Lipids; D048271:Chitosan; D001205:Ascorbic Acid