Facile, efficient, and catalyst-free electrophilic aminoalkoxylation of olefins: scope and application.
A new one-pot electrophilic aminoalkoxylation reaction using olefin, cyclic ether, amine, and N-bromosuccinimide has been developed. The olefinic substrates and the cyclic ether partners can be flexibly varied to produce a range of amino ether derivatives. This novel protocol has been applied in the facile and efficient synthesis of biologically active morpholine compounds.
Zhou
Ling
L
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Tan
Chong Kiat
CK
Zhou
Jing
J
Yeung
Ying-Yeung
YY
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D001974:Bromosuccinimide / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D000588:Amines; D009025:Morpholines; D001974:Bromosuccinimide