Geraniinic acid derivative from the leaves of Phyllanthus reticulatus.
Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl-5-[2',3',4'-trihydroxy-6'-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3'-tri-O-methylellagic acid, and methyl gallate were isolated from the dichloromethane extract. Determination of their structures was based on spectroscopic analysis. Compound 1 possessed a very weak insecticidal activity against Spodoptera frugiperda (Sf9) with an IC(50) value of 27.27 microg/mL.
Pojchaijongdee
Nuch
N
Department of Pharmacognosy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 73000.
Sotanaphun
Uthai
U
Limsirichaikul
Siripan
S
Poobrasert
Onoomar
O
D000818:Animals; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018411:Spodoptera
C553911:4,6-dimethoxycarbonyl-5-(2',3',4'-trihydroxy-6'-(methoxycarbonyl)phenyl)-5,6-dihydro-2H-pyran-2-one; D007306:Insecticides; D010936:Plant Extracts; D011753:Pyrones; D005707:Gallic Acid