Bioartificial liver support systems.
A variety of bioartificial liver support systems were developed to replace some of the liver's function in case of liver failure. Those systems, in contrast to purely artificial systems, incorporate metabolically active cells to contribute synthetic and regulatory functions as well as detoxification. The selection of the ideal cell source and the design of more sophisticated bioreactors are the main issues in this field of research. Several systems were already introduced into clinical studies to prove their safety. This review briefly introduces a cross-section of experimental and clinically applied systems and tries to give an overview on the problems and limitations of bioartificial liver support.
Pless
Gesine
G
Institut für Physiologische Chemie, Universitätsklinikum Essen, Essen, Germany.
D000818:Animals; D019149:Bioreactors; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D017093:Liver Failure / Q000628:therapy; D019164:Liver, Artificial / Q000639:trends