Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold.
A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.
He
Guijia
G
Department of Chemistry, Wichita State University, 206 McKinley Hall, 1845 Fairmount, Wichita, Kansas 67260, USA.
Dou
Dengfeng
D
Wei
Liuqing
L
Alliston
Kevin R
KR
Groutas
William C
WC
D015195:Drug Design; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D048289:Imidazolidines; D011480:Protease Inhibitors; D019272:Leukocyte Elastase