title: Select acetophenones modulate flagellar motility in chlamydomonas.
abstract: Acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, a process that requires co-ordinated flagellar motility. The structure-activity relationships of a series of acetophenones are reported, including acetophenones that affect flagellar motility and cell viability. Notably, 4-methoxyacetophenone, 3,4-dimethoxyacetophenone, and 4-hydroxyacetophenone induced negative phototaxis in Chlamydomonas, suggesting interference with activity of flagellar proteins and control of flagellar dominance.
authors.affiliation: Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341, USA.
authors.forename: Shakila K
authors.initials: SK
authors.lastname: Evans
authors.forename: Austin A
authors.initials: AA
authors.lastname: Pearce
authors.forename: Prudence K
authors.initials: PK
authors.lastname: Ibezim
authors.forename: Todd P
authors.initials: TP
authors.lastname: Primm
authors.forename: Anne R
authors.initials: AR
authors.lastname: Gaillard
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000494:pharmacology; D020418:Algal Proteins / Q000378:metabolism; D000840:Anisoles / Q000737:chemistry / Q000494:pharmacology; D002696:Chlamydomonas / Q000187:drug effects / Q000502:physiology*; D005407:Flagella / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008027:Light; D055668:Photochemical Processes; D013329:Structure-Activity Relationship
chemical_list: D000098:Acetophenones; D020418:Algal Proteins; D000840:Anisoles; C046029:4-acetylanisole; C031335:4-hydroxyacetophenone