Concise review: polarity in stem cells, disease, and aging.
Adult somatic stem cells are central to homeostasis in tissues that present with a high cellular turnover like the skin, intestine, and the hematopoietic system. It is thought that polarity is particularly important with respect to fate decisions on stem cell division (symmetric or asymmetric) as well as for the maintenance of stem cell adhesion and quiescence (interaction with the niche). Consequently the failure to establish or regulate stem cell polarity might result in disease or tissue attrition. Members of the family of small RhoGTPases are known to exert an important role in regulating cell polarity. We summarize and discuss here recent views on the role of cell polarity in somatic stem cell function, aging, and disease, concluding that targeting cell polarity might be a novel approach to ameliorate or even revert aberrant somatic stem cell function.
Florian
Maria Carolina
MC
Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.
Geiger
Hartmut
H
D053687:Adult Stem Cells / Q000201:enzymology* / Q000473:pathology; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D016764:Cell Polarity; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism*
D020764:cdc42 GTP-Binding Protein