Viral suppressors of RNA-based viral immunity: host targets.
RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral proteins as suppressors of RNA silencing provides strong validation for the effectiveness of RVI. Here we review recent studies that have revealed new mechanistic insights into plant and insect viral suppressors of RVI or suggested a role for RNA silencing suppression during mammalian viral infection.
Wu
Qingfa
Q
Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA.
Wang
Xianbing
X
Ding
Shou-Wei
SW
D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D010935:Plant Diseases / Q000276:immunology* / Q000821:virology; D034622:RNA Interference; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000276:immunology*
D014764:Viral Proteins