title: [Effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing].
abstract: OBJECTIVE
  To observe the effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing.
  
  
  METHODS
  One hundred and twenty ASA I or II elective patients undergoing general anesthesia were randomly allocated to optimized group or control group: the optimized group induced with midazolam 0.06 mg/kg, followed by fentanyl 1 mg/kg at 1 min later, vecuronium 0.1 mg/kg at 1 min 55 s, propofol 1.5-2 mg/kg at 2 min, a second dose of 3 mg/kg fentanyl at 2 min 20 s, intubated at time 5 min; the control group was induced with the same medication but all the fentanyl (4 mg/kg) was injected at time 1 min. Coughing after fentanyl injection was observed and hemodynamic parameters were recorded.
  
  
  RESULTS
  Hemodynamic changes were identical between the two groups indicated similar intubation response suppression. The incidence of fentanyl-induced coughing was significantly lower in the optimized group (4/60) than in the control group (23/60) (P < 0.01).
  
  
  CONCLUSIONS
  Optimizing anesthetic injecting sequence during induction by separate fentanyl into two boluses significantly reduce fentanyl-induced coughing without affecting intubation response suppression.
authors.affiliation: Department of Anesthesiology, Pinghu First People's Hospital, Zhejiang 314200, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Yao
authors.forename: Jun-jian
authors.initials: JJ
authors.lastname: Zhu
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Zhu
authors.forename: Da-chun
authors.initials: DC
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D005283:Fentanyl