title: Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold.
abstract: A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.
authors.affiliation: Department of Chemistry, Wichita State University, 206 McKinley Hall, 1845 Fairmount, Wichita, Kansas 67260, USA.
authors.forename: Guijia
authors.initials: G
authors.lastname: He
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Dou
authors.forename: Liuqing
authors.initials: L
authors.lastname: Wei
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Alliston
authors.forename: William C
authors.initials: WC
authors.lastname: Groutas
mesh_terms: D015195:Drug Design; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D048289:Imidazolidines; D011480:Protease Inhibitors; D019272:Leukocyte Elastase