title: Design of novel RNA ligands that bind stem-bulge HIV-1 TAR RNA.
abstract: We report here the rational design and the synthesis of a new series of RNA ligands. These molecules are constituted of various binding motifs that interact cooperatively with HIV-1 TAR RNA, used as a model.
authors.affiliation: LCMBA UMR6001 CNRS Université de Nice Sophia Antipolis, Faculté des Sciences, Parc Valrose 06100, Nice, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Duca
authors.forename: Vincent
authors.initials: V
authors.lastname: Malnuit
authors.forename: Florent
authors.initials: F
authors.lastname: Barbault
authors.forename: Rachid
authors.initials: R
authors.lastname: Benhida
mesh_terms: D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry*; D015497:HIV-1 / Q000235:genetics*; D008024:Ligands; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D012367:RNA, Viral / Q000737:chemistry*; D016601:RNA-Binding Proteins / Q000737:chemistry*; D000099253:Trans-Activation Responsive RNA-Binding Protein
chemical_list: D006001:Glycoconjugates; D008024:Ligands; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D000099253:Trans-Activation Responsive RNA-Binding Protein