Silica-based nanoparticles for photodynamic therapy applications.
Silica-based nanoparticles for applications in photodynamic therapy (PDT) have emerged as a promising field for the treatment of cancer. In this review, based on the pathway the photosensitizer is entrapped inside the silica matrix, the different methods for the synthesis of silica-based nanoparticles are described from the pioneering works to the latest achievements which concern multifunctional nanoplatforms, up-converting nanoparticles, two-photon PDT, vectorization and in vivo applications.
Couleaud
Pierre
P
Laboratoire Réactions et génie des Procédés, UPR 3349, Nancy-Université, 1, rue Grandville, 54000, Nancy, France.
Morosini
Vincent
V
Frochot
Céline
C
Richeter
Sébastien
S
Raehm
Laurence
L
Durand
Jean-Olivier
JO
D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*
D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D012822:Silicon Dioxide