title: Innate inflammatory response to the malarial pigment hemozoin.
abstract: Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host's innate inflammatory responses.
authors.affiliation: Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.
authors.forename: Marina T
authors.initials: MT
authors.lastname: Shio
authors.forename: Fikregabrail A
authors.initials: FA
authors.lastname: Kassa
authors.forename: Marie-Josée
authors.initials: MJ
authors.lastname: Bellemare
authors.forename: Martin
authors.initials: M
authors.lastname: Olivier
mesh_terms: D006420:Hemeproteins / Q000096:biosynthesis / Q000138:chemical synthesis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*
chemical_list: D006420:Hemeproteins; C020753:hemozoin