title: Use of the plasma CTX for assessing the bone activity of the mandible among osteopenic and osteoporotic patients.
abstract: The aim of this study was to determine whether the plasma CTX bone remodeling marker is useful for indicating the bone metabolic activity level of the mandible. Thirty-six patients were selected; all were postmenopausal and aged 50 years or over. In accordance with the WHO criteria for osteoporosis, a control group was set up (n = 10) in which the T-score was greater than -1 and a diseased group with T-score less than -1. Using MDP-(99m)Tc samples, the radioisotope uptake in the femoral neck (R(2)) and mandibular body (R(1)) was analyzed. A third examination was performed using the plasma CTX biochemical bone-modeling marker. The inferential results for the diseased group showed that Ln(R(1)) presented a statistically significant linear relationship with Ln(CTx) (p = 0.067) and with the T-score (p = 0.018). The plasma CTX bone remodeling marker is useful for monitoring the bone metabolic activity of the mandible.
authors.affiliation: Imaging Department, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Glacio
authors.initials: G
authors.lastname: Avolio
authors.forename: Cynthia
authors.initials: C
authors.lastname: Brandão
authors.forename: Marcelo
authors.initials: M
authors.lastname: Marcucci
authors.forename: Gilberto
authors.initials: G
authors.lastname: Alonso
mesh_terms: D015502:Absorptiometry, Photon; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D024042:Collagen Type I; D003720:Densitometry; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D016014:Linear Models; D008334:Mandible / Q000000981:diagnostic imaging / Q000378:metabolism*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides; D011347:Procollagen / Q000097:blood*; D011877:Radionuclide Imaging
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide