title: Wall motion estimation in intracranial aneurysms.
abstract: The quantification of wall motion in cerebral aneurysms is becoming important owing to its potential connection to rupture, and as a way to incorporate the effects of vascular compliance in computational fluid dynamics simulations. Most of papers report values obtained with experimental phantoms, simulated images or animal models, but the information for real patients is limited. In this paper, we have combined non-rigid registration with signal processing techniques to measure pulsation in real patients from high frame rate digital subtraction angiography. We have obtained physiological meaningful waveforms with amplitudes in the range 0 mm-0.3 mm for a population of 18 patients including ruptured and unruptured aneurysms. Statistically significant differences in pulsation were found according to the rupture status, in agreement with differences in biomechanical properties reported in the literature.
authors.affiliation: Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Oubel
authors.forename: J R
authors.initials: JR
authors.lastname: Cebral
authors.forename: M
authors.initials: M
authors.lastname: De Craene
authors.forename: R
authors.initials: R
authors.lastname: Blanc
authors.forename: J
authors.initials: J
authors.lastname: Blasco
authors.forename: J
authors.initials: J
authors.lastname: Macho
authors.forename: C M
authors.initials: CM
authors.lastname: Putman
authors.forename: A F
authors.initials: AF
authors.lastname: Frangi
mesh_terms: D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000503:physiopathology; D015901:Angiography, Digital Subtraction; D001696:Biomechanical Phenomena; D001808:Blood Vessels / Q000503:physiopathology*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009068:Movement; D012815:Signal Processing, Computer-Assisted