title: Deposition of trans fatty acid from industrial sources and its effect on different growth phases in rats.
abstract: Although the effects of trans fatty acids (TFA) from industrially produced sources (IP-TFA), such as partially hydrogenated vegetable oil, are reported, their implications on metabolism and growth are still not fully disclosed. In this study, female Wistar rats were assigned to control diet (AIN-93G) or Trans diet groups (5% IP-TFA) after gestation. The male offspring were classified and grouped as infant, weanling, and young adult (YA) rats (n = 10), and received the same control or Trans diets throughout their life span. Samples of abdominal adipose tissue, liver and plasma were collected to determine fatty acid profile and fasting glycemia. Morphometric analysis of the liver and hepatosomatic index determination were conducted. Deposition of TFA was observed in the liver, adipose tissue and plasma of IP-TFA-fed rats. Fasting glycemia concentration was higher in Trans YA rats than in the control YA group (p = 0.004). A higher accumulation of fat was observed in the liver of the Trans group than in the control group during the three phases. Hepatosomatic index was higher in the YA Trans group than in the YA control group (p < 0.05). Dietary TFA was deposited in the tissues and plasma and raised fasting glucose in growing rats.
authors.affiliation: Department of Nutrition and Health, Federal University of Viçosa, Brazil.
authors.forename: N M V
authors.initials: NM
authors.lastname: Lessa
authors.forename: V M
authors.initials: VM
authors.lastname: Nakajima
authors.forename: S L P
authors.initials: SL
authors.lastname: Matta
authors.forename: M C G
authors.initials: MC
authors.lastname: Peluzio
authors.forename: C M
authors.initials: CM
authors.lastname: Sabarense
authors.forename: N M B
authors.initials: NM
authors.lastname: Costa
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D044242:Trans Fatty Acids / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D007328:Insulin; D044242:Trans Fatty Acids