title: Postoperative autotransfusion of mediastinal shed blood does not influence haemostasis after elective coronary artery bypass grafting.
abstract: OBJECTIVE
  The rationale of using autotransfusion of mediastinal shed blood after cardiac surgery is to preserve haemoglobin levels and reduce the need for allogenic blood transfusions. However, the method is controversial and its clinical value has been questioned. We hypothesised that re-transfusion of mediastinal shed blood instead impairs haemostasis after routine coronary artery bypass grafting and thus increases postoperative bleeding.
  
  
  METHODS
  Seventy-seven consecutive elective coronary artery bypass surgery patients (mean age 67±9 years, 77% men) were included in a prospective, randomised controlled study. The patients were randomised to postoperative re-transfusion of mediastinal shed blood (n=39) or to a group where mediastinal shed blood was discarded (n=38). Primary end point was bleeding during the first 12 postoperative hours. Secondary end points were postoperative transfusion requirements, haemoglobin levels, thrombo-elastometric variables and plasma concentrations of interleukin-6, thrombin-anti-thrombin complex and D-dimer.
  
  
  RESULTS
  Mean re-transfused volume in the autotransfusion group was 282±210 ml. There was no difference in postoperative bleeding (median 394 ml (interquartile range 270-480) vs 385 (255-430) ml, p=0.69), proportion of patients receiving transfusions of blood products (11/39 vs 11/38, p=0.95), haemoglobin levels 24h after surgery (116±13 vs 116±14 g l(-1), p=0.87), thrombo-elastometric variables, interleukin-6 (219±144 vs 201±144 pg ml(-1), p=0.59), thrombin-anti-thrombin complex (11.0±9.1 vs 14.8±15, p=0.19) or D-dimer (0.56±0.49 vs 0.54±0.44, p=0.79) between the autotransfusion group and the no-autotransfusion group.
  
  
  CONCLUSIONS
  Autotransfusion of small-to-moderate amounts of mediastinal shed blood does not influence haemostasis after elective coronary artery bypass grafting.
authors.affiliation: Department of Cardiovascular Surgery and Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Helene
authors.initials: H
authors.lastname: Marberg
authors.forename: Anders
authors.initials: A
authors.lastname: Jeppsson
authors.forename: Gunnar
authors.initials: G
authors.lastname: Brandrup-Wognsen
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000601:surgery; D001803:Blood Transfusion; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000379:methods*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D019106:Postoperative Hemorrhage / Q000097:blood / Q000209:etiology / Q000628:therapy; D011446:Prospective Studies; D013916:Thrombelastography / Q000379:methods
chemical_list: D006454:Hemoglobins; D018836:Inflammation Mediators; D015850:Interleukin-6