title: Regional high-flow cerebral perfusion improves both cerebral and somatic tissue oxygenation in aortic arch repair.
abstract: BACKGROUND
  Regional cerebral perfusion provides cerebral circulatory support during aortic arch reconstruction. We report the effectiveness of high-flow regional cerebral perfusion (HFRCP) from the right innominate artery to maintain sufficient cerebral and somatic oxygen delivery through collateral vessels.
  
  
  METHODS
  Frontal cerebral and thoracolumbar probes to measure somatic regional oxygen saturation (rSo(2)) were used to continuously measure oxygenation during cardiopulmonary bypass in 18 patients (weight, 2.1 to 4.3 kg) who underwent arch reconstruction using HFRCP (mean flow, 82; range, 43 to 108 ml/kg/min). Procedures included 9 Norwood procedures, 5 coarctation of aorta/interruption of aorta complex repairs, and 4 aortic arch repairs for a single ventricle. Mean HFRCP duration was 51 + or - 17 minutes under moderate hypothermia. Mean radial arterial pressure was kept at less than 50 mm Hg during HFRCP, and chlorpromazine (mean dose, 2.8 mg/kg) was given to all patients before and during HFRCP to increase regional cerebral perfusion flow. Plasma lactate concentration was measured before and after HFRCP.
  
  
  RESULTS
  During HFRCP, mean cerebral rSo(2) was 78.8% + or - 9.5%, somatic rSo(2) was 65.4% + or - 12.1%, and lactate concentration increased from 3.8 + or - 2.2 to 5.5 + or - 2.1 mmol/L. There was significant correlation between regional cerebral perfusion flow and somatic rSo(2). Significant inverse correlations were noted between regional cerebral perfusion flow and the increase of lactate concentration and between somatic rSo(2) and the increase of lactate concentration.
  
  
  CONCLUSIONS
  High-flow regional cerebral perfusion preserved sufficient cerebral and somatic tissue oxygenation during aortic arch repair. The reduction of vascular resistance of collateral vessels increased both cerebral and somatic blood flow, resulting in improved tissue oxygen delivery.
authors.affiliation: Department of Cardiovascular Surgery, Kitasato University, School of Medicine, Kitasato 1-15-1, Sagamihara 228-8555, Japan. kagami111@aol.com
authors.forename: Kagami
authors.initials: K
authors.lastname: Miyaji
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kohira
authors.forename: Kei-Ichi
authors.initials: K
authors.lastname: Itatani
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tomoyasu
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Inoue
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Ohara
mesh_terms: D001013:Aorta, Thoracic / Q000601:surgery*; D001921:Brain / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D002560:Cerebrovascular Circulation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007430:Intraoperative Care / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D010477:Perfusion / Q000379:methods; D011446:Prospective Studies; D012039:Regional Blood Flow
chemical_list: D010100:Oxygen