title: A model of ventilation of the healthy human lung.
abstract: This paper presents a model of the lung mechanics which simulates the pulmonary alveolar ventilation. The model includes aspects of: the alveolar geometry; pressure due to the chest wall; pressure due to surface tension determined by surfactant activity; pressure due to lung tissue elasticity; and pressure due to the hydrostatic effects of the lung tissue and blood. The cross-sectional area of the lungs in the supine position derived from computed tomography is used to construct a horizontally layered model, which simulates heterogeneous ventilation distribution from the non-dependent to the dependent layers of the lungs. The model is in agreement with experimentally measured hysteresis of the pressure-volume curve of the lungs, static lung compliance, changes in lung depth during breathing and density distributions at total lung capacity (TLC) and residual volume (RV). In the dependent layers of the lungs, alveolar collapse may occur at RV, depending on the assumptions concerning lung tissue elasticity at very low alveolar volumes. The model simulations showed that ventilation increased with depth in the lungs, although not as pronounced as observed experimentally. The model simulates alveolar ventilation including all of the mentioned components of the respiratory system and to be validated against all the above mentioned experimental data.
authors.affiliation: Center for Model-Based Medical Decision Support, Aalborg University, Aalborg, Denmark.
authors.forename: K L
authors.initials: KL
authors.lastname: Steimle
authors.forename: M L
authors.initials: ML
authors.lastname: Mogensen
authors.forename: D S
authors.initials: DS
authors.lastname: Karbing
authors.forename: J
authors.initials: J
authors.lastname: Bernardino de la Serna
authors.forename: S
authors.initials: S
authors.lastname: Andreassen
mesh_terms: D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D012119:Respiration