title: [Value of endobronchial ultrasound-guided transbronchial needle aspiration in hilar and mediastinal lesions].
abstract: OBJECTIVE
  To evaluate the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in cases of undiagnosed intrapulmonary lesions.
  
  
  METHODS
  A total of 89 patients with intrathoracic lesions underwent EBUS-TBNA, including 56 pulmonary lesions, 7 lymph node staging in lung cancer patients, 21 unknown hilar and/or mediastinal lymphadenopathies and 5 mediastinal tumors. All samples were evaluated for cytological and pathological examinations.
  
  
  RESULTS
  No complication of EBUS-TBNA was observed. Among 89 cases, 76 had positive results, 5 negative and 5 cases excluded as unsatisfied samples. In 56 patients with pulmonary lesions, EBUS-TBNA demonstrated 45 malignant tumors, 5 benign diseases, 3 suspicious cancers, 1 negative and 2 unsatisfied samples. In 7 lung cancer patients staged by EBUS-TBNA, 5 showed metastasis and 2 showed no metastasis. In 21 cases with mediastinal and/or hilar lymphadenopathy, EBUS-TBNA demonstrated 3 malignant tumors, 13 benign diseases, 2 negative and 3 unsatisfied samples. All 5 mediastinal lesions were malignant. Three suspicious cancers were confirmed, 1 by CT-guided percutaneous transthoracic needle biopsy and 2 by clinical follow-ups. In 2 lung cancer patients EBUS-TBNA showed negative, 1 surgical sample showed metastasis and another no metastasis by PET-CT. Three negative cases were diagnosed as benign by clinical follow-ups. The diagnostic sensitivity, specificity, positive predictive value and negative predictive value of EBUS-TBNA were 95%, 100%, 100% and 20% respectively.
  
  
  CONCLUSIONS
  EBUS-TBNA is both effective and safe in making a diagnosis of intrathoracic lesions.
authors.affiliation: Department of Endoscopy, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Gui-yu
authors.initials: GY
authors.lastname: Cheng
authors.forename: Ning
authors.initials: N
authors.lastname: Lü
authors.forename: You-sheng
authors.initials: YS
authors.lastname: Mao
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Li
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Ni
authors.forename: Shao-qing
authors.initials: SQ
authors.lastname: Lai
authors.forename: Shun
authors.initials: S
authors.lastname: He
authors.forename: Gui-xiang
authors.initials: GX
authors.lastname: Yu
authors.forename: Feng-huan
authors.initials: FH
authors.lastname: Ju
authors.forename: Hua-ying
authors.initials: HY
authors.lastname: Xun
authors.forename: Rong-rong
authors.initials: RR
authors.lastname: Cheng
authors.forename: Pei-pei
authors.initials: PP
authors.lastname: Xu
authors.forename: Gui-qi
authors.initials: GQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D001999:Bronchoscopy; D019160:Endosonography; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis; D008175:Lung Neoplasms / Q000175:diagnosis*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis; D008875:Middle Aged; D009367:Neoplasm Staging