"Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site.
We have demonstrated the fabrication of "aligned-to-random" electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.
Xie
Jingwei
J
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA.
Li
Xiaoran
X
Lipner
Justin
J
Manning
Cionne N
CN
Schwartz
Annie G
AG
Thomopoulos
Stavros
S
Xia
Younan
Y
D000818:Animals; D003094:Collagen / Q000737:chemistry; D005347:Fibroblasts / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D013314:Stress, Mechanical; D013710:Tendons / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen