title: Novel 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs).
abstract: A series of 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H(+)/K(+) ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at N1, C5, and C7 position of 1H-pyrrolo[2,3-c]pyridine scaffold, we have observed that compounds 14f and 14g are potent APAs with H(+)/K(+) ATPase IC(50)=28 and 29 nM, respectively.
authors.affiliation: Yuhan Research Institute, Giheung-gu, Gyeonggi-do, Republic of Korea.
authors.forename: Young Ae
authors.initials: YA
authors.lastname: Yoon
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Byoung Moon
authors.initials: BM
authors.lastname: Lee
authors.forename: Tae Kyun
authors.initials: TK
authors.lastname: Kim
authors.forename: Myung Hun
authors.initials: MH
authors.lastname: Cha
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Sim
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Kim
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology; D020128:Inhibitory Concentration 50; D054328:Proton Pump Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013552:Swine
chemical_list: D054328:Proton Pump Inhibitors; D011725:Pyridines