Whitening effect of alpha-bisabolol in Asian women subjects.
Although skin pigmentation, which results from the production and distribution of melanin in the epidermis, is the major physiological defence against solar irradiation, hyperpigmentation is a common and distressing problem caused by various inflammatory skin disorders, such as eczema, allergic contact dermatitis and irritant contact dermatitis. We evaluated the effects of a preparation containing alpha-bisabolol on pigmented skin of a group of subjects. The effectiveness of the active compound, alpha-bisabolol, in a base-cream preparation for the treatment of pigmented skin was tested on 28 female subjects as follows: the cream was applied once a day to the back for 8 weeks. These same women also applied a vehicle control cream to the pigmented skin. The results were evaluated by clinical and biophysical test methods. After 8 weeks of treatment of the alpha-bisabolol-containing cream, there was significant lightening effect in the pigmented skin for the majority of the subjects who tested the cream.
Lee
J
J
Biospectrum Life Science Institute, Gyunggi Do, Suwon, Korea.
Jun
H
H
Jung
E
E
Ha
J
J
Park
D
D
D000287:Administration, Topical; D000328:Adult; D044466:Asian People; D003358:Cosmetics / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D012880:Skin Pigmentation / Q000187:drug effects / Q000502:physiology*; D013053:Spectrophotometry
D003358:Cosmetics; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C004497:bisabolol