NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip?
Induction of gene expression involves deployment of transcription factors. In this issue of Immunity, Farlik et al. (2010) provide a view in which cooperation between transcription factors NF-kappaB and ISGF3 divides the task of transcription by recruiting and activating distinct components of the transcriptional machinery.
Levy
David E
DE
NYU School of Medicine, 550 1(st) Avenue MSB550, New York, NY 10016, USA. david.levy@nyumc.org