title: Introduction to the biomechanics of carotid plaque pathogenesis and rupture: review of the clinical evidence.
abstract: The management of patients with asymptomatic carotid disease is currently under debate and new methods are warranted for better risk stratification. The role of the biomechanical properties of the atherosclerotic arterial wall together with the effect of different stress types in plaque destabilisation has only been recently investigated. PubMed and Scopus databases were reviewed. There is preliminary clinical evidence demonstrating that the analysis of the combined effect of the various types of biomechanical stress acting on the carotid plaque may help us to identify the vulnerable plaque. At present, MRI and two-dimensional ultrasound are combined with fluid-structure interaction techniques to produce maps of the stress variation within the carotid wall, with increased cost and complexity. Stress wall analysis can be a useful tool for carotid plaque evaluation; however, further research and a multidisciplinary approach are deemed as necessary for further development in this direction.
authors.affiliation: Vascular Surgery Department, Ealing Hospital, NHS Trust, London, UK. g.makris09@imperial.ac.uk
authors.forename: G C
authors.initials: GC
authors.lastname: Makris
authors.forename: A N
authors.initials: AN
authors.lastname: Nicolaides
authors.forename: X Y
authors.initials: XY
authors.lastname: Xu
authors.forename: G
authors.initials: G
authors.lastname: Geroulakos
mesh_terms: D000465:Algorithms; D050197:Atherosclerosis / Q000473:pathology* / Q000503:physiopathology; D001696:Biomechanical Phenomena; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000503:physiopathology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology; D020342:Finite Element Analysis; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D018810:Magnetic Resonance Angiography; D012422:Rupture, Spontaneous / Q000473:pathology / Q000503:physiopathology; D013314:Stress, Mechanical