Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population.
OBJECTIVE
To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk.


METHODS
We performed a hospital-based, case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals (304 gastric cancer patients and 304 age and sex matched cancer-free controls).


RESULTS
The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups (P = 0.037). Compared with CC genotype carriers, subjects with the variant genotypes (GC + GG) had a 58% increased risk of gastric cancer (adjusted OR = 1.58, 95% CI: 1.11-2.20, P = 0.009). Moreover, a higher gastric cancer risk was especially evident in younger individuals aged < or =58 years, nonsmokers, and males (adjusted OR = 1.76, 95% CI: 1.08-2.87, P = 0.024; adjusted OR = 1.55, 95% CI: 1.06-2.28, P = 0.025; adjusted OR = 1.53, 95% CI: 1.04-2.27, P = 0.033; respectively).


CONCLUSIONS
Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.
Zeng
Ying
Y
Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Sun
Qing-Min
QM
Liu
Nan-Nan
NN
Dong
Guang-Hui
GH
Chen
Jie
J
Yang
Li
L
Wang
Bin
B
D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*
C542542:MIRN146 microRNA, human; D035683:MicroRNAs