Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study.
BACKGROUND
Effects of vitamin D repletion in young people with low vitamin D status have not been investigated so far.


OBJECTIVE
We evaluated the effect of a single massive dose of cholecalciferol on calcium metabolism at 3, 15, and 30 d, compared to baseline.


METHODS
We conducted a prospective intervention study in an ambulatory care setting.


METHODS
Forty-eight young subjects with vitamin D deficiency participated in the study.


METHODS
A single oral dose of 600,000 IU of cholecalciferol was administered to each subject.


METHODS
We evaluated serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, calcium, and PTH induced by a single load of cholecalciferol.


RESULTS
The 25(OH)D level was 15.8 ± 6.5 ng/ml at baseline and became 77.2 ± 30.5 ng/ml at 3 d (P < 0.001) and 62.4 ± 26.1 ng/ml at 30 d (P < 0.001). PTH levels concomitantly decreased from 53.0 ± 20.1 to 38.6 ± 17.2 pg/ml at 3 d and to 43.4 ± 14.0 pg/ml at 30 d (P < 0.001 for both). The trends were maintained in a subgroup followed up to 90 d (P < 0.001). Mean serum Ca and P significantly increased compared to baseline, whereas serum Mg decreased at 3 d. 1,25-Dihydroxyvitamin D significantly increased from 46.8 ± 18.9 to 97.8 ± 38.3 pg/ml at 3 d (P < 0.001) and to 59.5 ± 27.3 pg/ml at 60 d (P < 0.05).


CONCLUSIONS
A single oral dose of 600,000 IU of cholecalciferol rapidly enhances 25(OH)D and reduces PTH in young people with vitamin D deficiency.
Cipriani
Cristiana
C
Department of Clinical Sciences, University of Rome Sapienza, Rome, Italy. cristianac@alice.it
Romagnoli
Elisabetta
E
Scillitani
Alfredo
A
Chiodini
Iacopo
I
Clerico
Rita
R
Carnevale
Vincenzo
V
Mascia
Maria Lucia
ML
Battista
Claudia
C
Viti
Raffaella
R
Pileri
Mauro
M
Eller-Vainicher
Cristina
C
Minisola
Salvatore
S
D000284:Administration, Oral; D000328:Adult; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000188:drug therapy*; D055815:Young Adult
D006728:Hormones; D010281:Parathyroid Hormone; D014807:Vitamin D; D002762:Cholecalciferol; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium