[Telomeres and telomerase as targeted therapies in cancer treatment].
Advances in chromosome dynamics have increased our understanding of the significant role of telomeres and telomerase in cancer. Telomerase is expressed in almost all cancer cells but is inactive in most normal somatic cells. Therefore, telomerase is an important target for the design of therapeutic agents that might have minimal side effects. Herein, we evaluate current approaches to telomerase/telomere-targeted therapy, discuss the benefits and disadvantages, and speculate on the future direction of telomerase inhibitors as cancer therapeutics.
Souiden
Y
Y
Hôpital Ibn-El-Jazzar, Kairouan, Tunisie. souidenyousra@yahoo.fr
Bouraoui
A
A
Chaieb
K
K
Mahdouani
K
K
D002455:Cell Division / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005544:Forecasting; D054856:G-Quadruplexes; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D009841:Oligonucleotides / Q000627:therapeutic use; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D012313:RNA; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D016337:RNA, Catalytic / Q000627:therapeutic use; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000037:antagonists & inhibitors; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000502:physiology; D016615:Telomere / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D035321:Telomeric Repeat Binding Protein 1 / Q000502:physiology; D035341:Telomeric Repeat Binding Protein 2 / Q000502:physiology; D014158:Transcription, Genetic
D004791:Enzyme Inhibitors; C505952:GRN163L peptide; D009363:Neoplasm Proteins; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D016337:RNA, Catalytic; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D018894:Reverse Transcriptase Inhibitors; D035321:Telomeric Repeat Binding Protein 1; D035341:Telomeric Repeat Binding Protein 2; C422952:telomerase RNA; D012313:RNA; C509186:TERT protein, human; D019098:Telomerase