title: Fabrication of micropatterns of nanoarrays on a polymeric gel surface.
abstract: Micro-nano patterns of gold on the surface of poly(ethylene glycol) (PEG) hydrogels were prepared. The approach combines the technique of conventional photolithography (a top-down method for micropatterns), block copolymer micelle nanolithography (a bottom-up method for gold nanopatterns), and a linker-assistant technique to transfer a pattern on a hard surface to a polymeric surface. Hybrid micro-nano patterns on hydrogels were characterized using scanning electron microscopy, atomic force microscopy and X-ray photoelectron spectroscopy. The patterned Au nanoparticles were further modified by a peptide containing arginine-glycine-aspatate (RGD). The cell-adhesion contrast of the patterned hydrogel surface was confirmed by preliminary cell experiments.
authors.affiliation: Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Jianguo
authors.initials: J
authors.lastname: Sun
authors.forename: Jinghuan
authors.initials: J
authors.lastname: Huang
authors.forename: Rong
authors.initials: R
authors.lastname: Peng
authors.forename: Jian
authors.initials: J
authors.lastname: Tang
authors.forename: Jiandong
authors.initials: J
authors.lastname: Ding
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D006046:Gold / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D018625:Microscopy, Atomic Force; D009842:Oligopeptides / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D020100:Hydrogels; D009842:Oligopeptides; D011108:Polymers; D011092:Polyethylene Glycols; D006046:Gold; C047981:arginyl-glycyl-aspartic acid