Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right.
Nodal flow orients the left-right axis in some vertebrates, and is generated by clockwise-rotating cilia that are tilted posteriorly. In a recent paper, Song et al. add to mounting evidence that the planar cell polarity (PCP) pathway coordinates posterior positioning of cilia and subsequent determination of left-right asymmetry.
Santos
Nicole
N
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-2324, USA.
Reiter
Jeremy F
JF