title: [Investigation of factors associated with time change in breath alcohol concentration after paclitaxel administration].
abstract: Paclitaxel (PTX) injection is presently used for various types of cancer therapy. Because PTX is an insoluble medicine, alcohol is included. Therefore, after PTX administration, the breath alcohol concentration (BAC) detected is reported. We measured BAC after PTX administration and conducted an investigation into change over time. We also investigated factors associated with BAC. As a result, the BAC rate of detection just after the PTX administration was 52%. BAC was confirmed 3 hours after the administration. Therefore, sufficient rest periods were necessary after PTX administration and the need to avoid driving was proved. From comparison of the BAC detected and undetected groups, no significant sex differences were found in the BAC detected group in age, dosage, or body surface area. However, about a dosage per the time, many other things were significant in the BAC detected group in terms of dosage per time. From these results, it was suggested that the BAC detection rate rose with the dosage per time. However, one cannot predict BAC detection by the usual medical examination. Thus, when receiving PTX treatment on an outpatient basis, the patient should be warned not to drive to and from the clinic.
authors.affiliation: Department of Pharmacy, JA Hokkaido-kouseiren Sapporo-kosei General Hospital.
authors.forename: Ryoo
authors.initials: R
authors.lastname: Taniguchi
authors.forename: Norika
authors.initials: N
authors.lastname: Henmi
authors.forename: Riki
authors.initials: R
authors.lastname: Hirata
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tada
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sato
authors.forename: Fujiko
authors.initials: F
authors.lastname: Kamada
authors.forename: Miki
authors.initials: M
authors.lastname: Katsuragawa
authors.forename: Jun
authors.initials: J
authors.lastname: Matsunami
authors.forename: Ryu
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Akio
authors.initials: A
authors.lastname: Shibanami
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tsumaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000438:Alcohols / Q000032:analysis*; D001944:Breath Tests; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000438:Alcohols; D017239:Paclitaxel