title: Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout.
abstract: We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles. We treated rainbow trouts with different concentrations of deltamethrin (0.25 microg/L, 1 microg/L and 2.5 microg/L) and observed the alterations in mRNA expression levels of IGF-I, IGF-II and GH-I at different time intervals (at 6th, 12th, 24th, 48th, 72nd hours and 30th day). The mRNA levels significantly decreased with increasing deltamethrin concentrations for acute administration. Interestingly, a significant recovery in GH-I expression was seen after the 72nd hour up to 30th day while no significant differences were observed for IGF-I and IGF-II between the same time intervals. Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I, IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction.
authors.affiliation: Atatürk University, Agriculture Faculty, Department of Agricultural Biotechnology, 25240, Erzurum, Turkey. ercuaksakal@gmail.com
authors.forename: Ercüment
authors.initials: E
authors.lastname: Aksakal
authors.forename: Saltuk Buğrahan
authors.initials: SB
authors.lastname: Ceyhun
authors.forename: Orhan
authors.initials: O
authors.lastname: Erdoğan
authors.forename: Deniz
authors.initials: D
authors.lastname: Ekinci
mesh_terms: D000818:Animals; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009132:Muscles / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009570:Nitriles / Q000633:toxicity*; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000378:metabolism*; D011722:Pyrethrins / Q000633:toxicity*; D012333:RNA, Messenger / Q000378:metabolism; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism*; D023382:Toxicity Tests, Acute
chemical_list: D007306:Insecticides; D009153:Mutagens; D009570:Nitriles; D011722:Pyrethrins; D012333:RNA, Messenger; D013002:Somatomedins; C017180:decamethrin; D013006:Growth Hormone