In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated Candidiasis.
The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.
Kucharíková
Sona
S
Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium.
Tournu
Hélène
H
Holtappels
Michelle
M
Van Dijck
Patrick
P
Lagrou
Katrien
K
D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology; D057785:Catheters / Q000009:adverse effects* / Q000382:microbiology*; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley
D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin