Intraocular tuberculosis.
Intraocular manifestations of tuberculosis (TB) are rare, but TB infection is common worldwide, especially in developing economies, and in immigrant populations and immunocompromised patients in developed nations. The current review focuses on the clinical characteristics and diagnostic modalities useful in the diagnosis of intraocular TB. Specifically, IFN-gamma Release Assays (IGRAs), antigen-detection assays, and polymerase chain reactions will be discussed. Clinical management of TB patients includes counseling and testing for HIV infection. The use of corticosteroids along with anti-tuberculous medications and special therapeutic considerations in immunocompromised patients are discussed.
Cutrufello
Nicholas J
NJ
Bascom Palmer Eye Institute, Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Karakousis
Petros C
PC
Fishler
Jane
J
Albini
Thomas A
TA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects* / Q000276:immunology; D007371:Interferon-gamma / Q000032:analysis; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D014392:Tuberculosis, Ocular / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
D000305:Adrenal Cortex Hormones; D000942:Antigens, Bacterial; D000995:Antitubercular Agents; C072681:Mycobacterium tuberculosis antigens; D007371:Interferon-gamma