title: Sensitivity study of an ultrasound coupled transrectal electrical impedance tomography system for prostate imaging.
abstract: In 2009, prostate cancer ranked as the most common cancer and the second most fatal cancer in men in the United States. Unfortunately, the current clinical diagnostic methods (e.g. prostate-specific antigen (PSA), digital rectal examination, endorectal MRI, transrectal ultrasound, biopsy) used for detecting and staging prostate cancer are limited. It has been shown that cancerous prostate tissue has significantly different electrical properties when compared to benign tissues. Based on these electrical property findings, a transrectal electrical impedance tomography (TREIT) system is proposed as a novel prostate imaging modality. The TREIT system comprises an array of electrodes interfaced with a clinical transrectal ultrasound (TRUS) probe. We evaluate this imaging system through a series of phantom imaging experiments to assess the system's ability to image high and low contrast objects at various positions. We found that the TREIT system can easily discern high contrast inclusions of 1 cm in diameter at distances centered at two times the radius of the TREIT probe away from the probe surface. Furthermore, this technology's ability to detect low contrast inclusions suggests that it has the potential to successfully detect prostate cancer.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA. yuqing.wan@dartmouth.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Wan
authors.forename: R
authors.initials: R
authors.lastname: Halter
authors.forename: A
authors.initials: A
authors.lastname: Borsic
authors.forename: P
authors.initials: P
authors.lastname: Manwaring
authors.forename: A
authors.initials: A
authors.lastname: Hartov
authors.forename: K
authors.initials: K
authors.lastname: Paulsen
mesh_terms: D017097:Electric Impedance; D006801:Humans; D008297:Male; D019047:Phantoms, Imaging; D011467:Prostate / Q000000981:diagnostic imaging*; D012007:Rectum; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography