title: Short cationic antimicrobial peptides interact with ATP.
abstract: The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. α-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.
authors.affiliation: Centre for Microbial Diseases and Immunity Research, University of British Columbia, No 2259 Lower Mall Research Station, Vancouver, British Columbia V6T 1Z3, Canada. kai.hilpert@web.de
authors.forename: Kai
authors.initials: K
authors.lastname: Hilpert
authors.forename: Brett
authors.initials: B
authors.lastname: McLeod
authors.forename: Jessie
authors.initials: J
authors.lastname: Yu
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Elliott
authors.forename: Marina
authors.initials: M
authors.lastname: Rautenbach
authors.forename: Serge
authors.initials: S
authors.lastname: Ruden
authors.forename: Jochen
authors.initials: J
authors.lastname: Bürck
authors.forename: Claudia
authors.initials: C
authors.lastname: Muhle-Goll
authors.forename: Anne S
authors.initials: AS
authors.lastname: Ulrich
authors.forename: Sandro
authors.initials: S
authors.lastname: Keller
authors.forename: Robert E W
authors.initials: RE
authors.lastname: Hancock
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism* / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D049409:Luciferases, Firefly / Q000378:metabolism
chemical_list: D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; D000255:Adenosine Triphosphate; D049409:Luciferases, Firefly; D004259:DNA-Directed DNA Polymerase