title: Computational model of evolving lens capsule biomechanics following cataract-like surgery.
abstract: Cataract surgery is an invasive procedure whereby lens fibers are removed through a permanent central hole, or capsulorhexis, in the surrounding lens capsule and replaced with an artificial intraocular lens (IOL). Remnant lens epithelial cells subsequently transdifferentiate to a more contractile and synthetic wound-healing phenotype, which causes significant structural and mechanical adaptations of the residual lens capsule. The goal of this study is to present a computational model capable of capturing salient features of the biomechanical evolution of the lens capsule following cataract-like surgery. The model is shown to predict marked long-term increases in thickness and stiffness of the lens capsule nearest the edge of the capsulorhexis comparable to reported measurements. Such models represent a first step toward understanding better the long-term interactions between the residual lens capsule and implanted IOL, thus initiating a new paradigm for the design of improved IOLs, including those having an accommodative feature.
authors.affiliation: Department of Bioengineering, Royal School of Mines, Imperial College London, London, SW7 2AZ, UK. r.pedrigi@imperial.ac.uk
authors.forename: R M
authors.initials: RM
authors.lastname: Pedrigi
authors.forename: J D
authors.initials: JD
authors.lastname: Humphrey
mesh_terms: D000818:Animals; D002387:Cataract Extraction; D003198:Computer Simulation; D055119:Elastic Modulus; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000503:physiopathology* / Q000601:surgery*; D008954:Models, Biological; D013314:Stress, Mechanical