title: Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type.
abstract: Beclin 1 plays an important role in autophagy, differentiation, antiapoptosis and the development and progression of cancer. The function and expression of Beclin 1 in natural killer T-cell lymphoma is largely unexplored. The study aimed to investigate Beclin 1 expression and its relationship with prognosis in extranodal natural killer T-cell lymphoma, nasal type (EN KL). Beclin 1 protein expression in 65 tumor specimens from patients newly diagnosed with EN KL was examined by immunohistochemistry (IH C). The clinical significance of Beclin 1 in EN KL was statistically analyzed. Immunopositivity for Beclin 1 was found in 56 (86.2%) of the 65 samples. Low Beclin 1 expression was significantly associated with advanced Ann Arbor stage, intermediate to high IPI risk and elevated LDH level. Low Beclin 1 expression was associated with worse overall survival (OS; p = 0.001) and progression-free survival (PFS; p = 0.017). In multivariate analysis, Beclin1 expression, advanced Ann Arbor stage and B symptoms were found to be independent prognostic factors of OS and PFS. Consequently, a new clinico-pathological prognostic model was proposed. The model could discriminate different survival outcomes between low risk and high risk groups based on OS and PFS (p < 0.0001, respectively). Beclin1 expression is predictive of prognosis in EN KL. The new clinico-pathological prognostic model may be help identify patients with different clinical outcomes.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Department of Medical Oncology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Huang
authors.forename: Hao-Ran
authors.initials: HR
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Jiang
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Xu
authors.forename: Hui-Qiang
authors.initials: HQ
authors.lastname: Huang
authors.forename: Yue
authors.initials: Y
authors.lastname: Lv
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Xia
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zhu
authors.forename: Tong-Yu
authors.initials: TY
authors.lastname: Lin
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D000071186:Beclin-1; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D008954:Models, Biological; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D055815:Young Adult
chemical_list: D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D008565:Membrane Proteins