title: Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects.
abstract: Calcium phosphate glass (CPG) is well-documented alloplastic bone graft material. The objective of this study was to evaluate the osteoconductive effect of newly developed calcium phosphate glass cement (CPGC) in rabbit calvarial defects. Three circular defects (8 mm diameter) were created on the rabbit calvarium. One defect was filled with biphasic calcium phosphate (BCP group) and one defect was filled with CPGC (CPGC group). The remaining defect was not filled as the control. Histologic and histometric analysis were performed at four and eight weeks following the implantation of materials. One-way ANOVA method was used to evaluated the significance between three groups (p < 0.05). The CPGC group did not show a statistical difference in new bone area compared with the control at all healing periods, but the bone formation rate of CPGC seemed to increase between four and eight weeks. This suggests the bone formation rate of CPGC is initially slow, but increases at a specific time, showing the possibility of greater bone formation with time. The resorption rate of CPGC was greater than BCP. Within the limits of this study, CPGC demonstrated good space maintaining capacity and had an osteoconductive effect, suggesting it could be successfully used to improve bone formation capacity.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration College of Dentistry, Yonsei University, Seoul 120-752, Korea.
authors.forename: Hyun-Chang
authors.initials: HC
authors.lastname: Lim
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Sohn
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Park
authors.forename: Yoo-Jung
authors.initials: YJ
authors.lastname: Um
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
authors.forename: Chang-Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Yong-Keun
authors.initials: YK
authors.lastname: Lee
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D001862:Bone Resorption; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000494:pharmacology*; D005898:Glass; D007700:Kinetics; D010012:Osteogenesis; D011817:Rabbits; D012886:Skull / Q000293:injuries*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates