Human non-CG methylation: are human stem cells plant-like?
Non-CG methylation is well characterized in plants, where it appears to play a role in gene silencing and genomic imprinting. Although strong evidence for the presence of non-CG methylation in animals has been available for some time, both its origin and function remain elusive. In this review we discuss available evidence on non-CG methylation in animals in light of evidence suggesting that the human stem cell methylome contains significant levels of methylation outside the CG site.
Dyachenko
Olga V
OV
Pushchino Branch, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
Schevchuk
Tara V
TV
Kretzner
Leo
L
Buryanov
Yaroslav I
YI
Smith
Steven S
SS
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000378:metabolism; D018744:DNA, Plant / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010944:Plants / Q000235:genetics* / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*
D018744:DNA, Plant; D015254:DNA Modification Methylases