[Heart rate variability, adrenomedullin and B-type natriuretic peptide before and after transcatheter closure in children with patent ductus arteriosus].
OBJECTIVE
To observe the changes of heart rate variability (HRV), adrenomedullin (ADM) and B-type natriuretic peptide (BNP) before and after transcatheter closure in children with patent ductus arteriosus.


METHODS
HRV spectral values (TF, VLF, LF, HF, LF/HF) were detected by 24 dynamic electrocardiogram and the concentrations of plasma ADM and BNP were measured in 55 children with patent ductus arteriosus (Group PDA, n = 55) before and 3(rd) day, 3(rd) month after transcatheter closure therapy, and in 60 normal children (Group C).


RESULTS
(1) Compared with Group C, the HRV spectral values (TF, VLF, HF) were significantly lower (all P < 0.01), LF/HF and the concentrations of plasma ADM, BNP were significantly higher in patients with PDA before transcatheter closure (all P < 0.01). (2) Compared with the values before transcatheter closure values, plasma ADM were significantly reduced at 3(rd) day and 3(rd) month after transcatheter closure (P < 0.01), the HRV spectral values (TF, VLF, HF) were significantly increased while LF/HF and plasma BNP were significantly decreased at 3(rd) month after transcatheter closure (P < 0.01 or P < 0.05).


CONCLUSIONS
HRV and plasma ADM, BNP improved significantly post transcatheter closure in children with patent ductus arteriosus.
Wu
Rong-zhou
RZ
Department of Pediatric Cardiovascular, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Rong
Xing
X
Ren
Yue
Y
He
Xu-xiang
XX
Xiang
Ru-lian
RL
D000293:Adolescent; D053607:Adrenomedullin / Q000097:blood*; D006328:Cardiac Catheterization; D002648:Child; D004374:Ductus Arteriosus, Patent / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D055815:Young Adult
D020097:Natriuretic Peptide, Brain; D053607:Adrenomedullin