title: [Prenatal exposure to organochlorine pesticides and cryptorchidism].
abstract: Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ss-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid-based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ss-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pp'DDT and ss-HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fetal development.
authors.affiliation: Universidad Autónoma del Estado de México, Toluca, Estado de México. patriciiab@yahoo.com.mx
authors.forename: Lília Patrícia
authors.initials: LP
authors.lastname: Bustamante Montes
authors.forename: Stefan
authors.initials: S
authors.lastname: Waliszewski
authors.forename: María
authors.initials: M
authors.lastname: Hernández-Valero
authors.forename: Luz
authors.initials: L
authors.lastname: Sanín-Aguirre
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Infanzón-Ruiz
authors.forename: Arlette García
authors.initials: AG
authors.lastname: Jañas
mesh_terms: D003456:Cryptorchidism / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood / Q000633:toxicity*; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*
chemical_list: D006843:Hydrocarbons, Chlorinated; D010575:Pesticides