title: Ocular adnexal lymphoma and Helicobacter pylori gastric infection.
abstract: There is a causal association between Helicobacter pylori (Hp) gastric infection and the development of gastric MALT lymphoma. In contrast, the link between Hp gastric infection and the development of extragastric lymphoma has not been thoroughly investigated. We, therefore, studied the prevalence of gastric Hp infection at initial diagnosis of ophthalmologic and nonophthalmologic extragastric lymphoma patients. Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extraophthalmologic extragastric lymphoma, and a third one of 156 control individuals (control) without malignant lymphoma. Gastric Hp infection was investigated by histopathological analysis and Hp-specific PCR assay on gastric biopsy tissue samples. We found gastric Hp infection in 37 OAL patients (45%), in 25 extraophthalmologic extragastric lymphoma cases (25%), and in 18 controls individuals (12%) (P < 0.0001 OAL/C and P < 0.01 OAL/extra-OAL cases). Gastritis was found in 51% and 9% of Hp-positive and Hp-negative lymphoma patients, respectively (P < 10(-4)). Gastric Hp infection only correlated with MALT/LPL lymphoma (P = 0.03). There is a significant association between gastric Hp infection and MALT/LPL OAL. This suggests a novel mechanism of indirect infection-associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B-cell lymphoma.
authors.affiliation: Department of Clinical Hematology, Institut Curie, 26 rue d'Ulm, Paris cedex 05, France. sobrien@mdanderson.org
authors.forename: Didier
authors.initials: D
authors.lastname: Decaudin
authors.forename: Agnès
authors.initials: A
authors.lastname: Ferroni
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
authors.forename: Kheira
authors.initials: K
authors.lastname: Beldjord
authors.forename: Pierre
authors.initials: P
authors.lastname: Validire
authors.forename: Patricia
authors.initials: P
authors.lastname: de Cremoux
authors.forename: Patricia
authors.initials: P
authors.lastname: Validire
authors.forename: Corine
authors.initials: C
authors.lastname: Plancher
authors.forename: Claire
authors.initials: C
authors.lastname: Mathiot
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Macintyre
authors.forename: Bernard
authors.initials: B
authors.lastname: Asselain
authors.forename: Jacques
authors.initials: J
authors.lastname: Girodet
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mal
authors.forename: Nicole
authors.initials: N
authors.lastname: Brousse
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Beretti
authors.forename: Rémi
authors.initials: R
authors.lastname: Dendale
authors.forename: Livia
authors.initials: L
authors.lastname: Lumbroso-Le Rouic
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005134:Eye Neoplasms / Q000382:microbiology / Q000473:pathology; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged