Detection of DNA of six human herpesviruses in the cerebrospinal fluid of immunocompetent non-herpetic acute limbic encephalitis patients.
In order to determine whether six other human herpesviruses, aside from herpes simplex virus, are associated with non-herpetic acute limbic encephalitis in immunocompetent individuals, real-time PCR was used to detect the DNA of herpesviruses in CSF collected from 61 patients with this form of encephalitis. Five of the human herpesviruses tested were not detected in any of the 61 CSF samples. EBV DNA was detected in one CSF sample. The EBV DNA-positive patient was a 36-year-old woman who presented with fever, headache, mild somnolence, and the typical neuroimaging findings.
Yoshikawa
Tetsushi
T
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. tetsushi@fujita-hu.ac.jp
Asano
Yoshizo
Y
Takahashi
Yukitoshi
Y
D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000134:cerebrospinal fluid* / Q000235:genetics; D005260:Female; D006564:Herpesviridae / Q000235:genetics / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000821:virology*; D006801:Humans; D016867:Immunocompromised Host; D020363:Limbic Encephalitis / Q000134:cerebrospinal fluid / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D055815:Young Adult
D004279:DNA, Viral