Adverse outcomes among Aboriginal patients receiving peritoneal dialysis.
BACKGROUND
The Aboriginal population in Canada experiences high rates of end-stage renal disease and need for dialytic therapies. Our objective was to examine rates of mortality, technique failure and peritonitis among adult aboriginal patients receiving peritoneal dialysis in the province of Manitoba. We also aimed to explore whether differences in these rates may be accounted for by location of residence (i.e., urban versus rural).


METHODS
We included all adult patients residing in the province of Manitoba who received peritoneal dialysis during the period from 1997-2007 (n = 727). We extracted data from a local administrative database and from the Canadian Organ Replacement Registry and the Peritonitis Organism Exit-sites/Tunnel infections (POET) database. We used Cox and logistic regression models to determine the relationship between outcomes and Aboriginal ethnicity. We performed Kaplan-Meier analyses to examine the relationship between outcomes and urban (i.e., 50 km or less from the primary dialysis centre in Winnipeg) versus rural (i.e., more than 50 km from the centre) residency among patients who were aboriginal.


RESULTS
One hundred sixty-one Aboriginal and 566 non-Aboriginal patients were included in the analyses. Adjusted hazard ratios for mortality (HR 1.476, CI 1.073-2.030) and adjusted time to peritonitis (HR 1.785, CI 1.352-2.357) were significantly higher among Aboriginal patients than among non-Aboriginal patients. We found no significant differences in mortality, technique failure or peritonitis between urban- or rural-residing Aboriginal patients.


CONCLUSIONS
Compared with non-Aboriginal patients receiving peritoneal dialysis, Aboriginal patients receiving peritoneal dialysis had higher mortality and faster time to peritonitis independent of comorbidities and demographic characteristics. This effect was not influenced by place of residence, whether rural or urban.
Sood
Manish M
MM
Departments of Medicine, St. Boniface Hospital, Winnipeg, Man. msood@sbgh.mb.ca
Komenda
Paul
P
Sood
Amy R
AR
Reslerova
Martina
M
Verrelli
Mauro
M
Sathianathan
Chris
C
Eng
Loretta
L
Eng
Amanda
A
Rigatto
Claudio
C
D000328:Adult; D005260:Female; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008350:Manitoba; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D016016:Proportional Hazards Models; D044469:Racial Groups; D012424:Rural Population; D016896:Treatment Outcome; D014505:Urban Population