title: Electrochemical determination of gatifloxacin, moxifloxacin and sparfloxacin fluoroquinolonic antibiotics on glassy carbon electrode in pharmaceutical formulations.
abstract: Three fluoroquinolones; gatifloxacin (GAT), moxifloxacin (MOX) and sparfloxacin (SPAR) were electrochemically studied in various buffer systems at different pH values, using a glassy carbon electrode. The three fluoroquinolones were electrochemically oxidized at potential range (0.65-1.1 V) vs Ag-AgCl-KCl. The oxidation was irreversible and exhibited adsorption-controlled process behavior at all pH values and buffers studied. An electroanalytical methodology based on the adsorptive behavior of fluoroquinolones on glassy carbon electrode (GCE) and according to the linear relation between peak current and concentration using differential pulse voltammetry (DPV) method was successfully applied to the determination of the three fluoroquinolones in bulk and tablets. The proposed methods were statistically in agreement with that obtained by spectrophotometric comparison method.
authors.affiliation: Department of Chemistry, Faculty of Science (Dumyat), Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com
authors.forename: Abd-Elgawad
authors.initials: AE
authors.lastname: Radi
authors.forename: Tarek
authors.initials: T
authors.lastname: Wahdan
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Anwar
authors.forename: Hend
authors.initials: H
authors.lastname: Mostafa
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis*; D001372:Aza Compounds / Q000032:analysis*; D002244:Carbon; D004563:Electrochemistry; D004566:Electrodes; D024841:Fluoroquinolones / Q000032:analysis*; D000077734:Gatifloxacin; D006863:Hydrogen-Ion Concentration; D000077266:Moxifloxacin; D011804:Quinolines / Q000032:analysis*; D013607:Tablets
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D013607:Tablets; D002244:Carbon; D000077734:Gatifloxacin; C061363:sparfloxacin; D000077266:Moxifloxacin