title: Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.
abstract: N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, Laboratoire de Chimie Thérapeutique, Cibles et Médicaments des Infections, de l'Immunité et du Cancer, IICiMed UPRES EA 1155, Faculté de Pharmacie, Nantes, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Giraud
authors.forename: Pascal
authors.initials: P
authors.lastname: Marchand
authors.forename: Delphine
authors.initials: D
authors.lastname: Carbonnelle
authors.forename: Michael
authors.initials: M
authors.lastname: Sartor
authors.forename: François
authors.initials: F
authors.lastname: Lang
authors.forename: Muriel
authors.initials: M
authors.lastname: Duflos
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D007211:Indoles / Q000737:chemistry; D020128:Inhibitory Concentration 50; D051379:Mice
chemical_list: D000577:Amides; D007166:Immunosuppressive Agents; D007211:Indoles