title: Use of an immunization information system to assess the effectiveness of pentavalent rotavirus vaccine in US children.
abstract: Immunization information systems (IISs) are accessible sources of immunization data. We validated immunization information from a local IIS against provider records and assessed the system's utility in evaluating vaccine effectiveness against rotavirus disease using a case-control study. Among the 91% of case and control patients with immunization records, 49% were in the IIS, and 97% had a provider record. Good agreement was observed across record sources (k=0.65). Vaccine effectiveness (VE) was 82% using IIS data compared to 82-88% using provider data. Controls identified through the IIS provided VE estimates similar to hospital control patients. IISs could represent a valuable source of data for effectiveness evaluations.
authors.affiliation: Center for Vaccine Awareness and Research, Texas Children's Hospital, Houston, TX, USA. lcsahni@texaschildrens.org
authors.forename: Leila C
authors.initials: LC
authors.lastname: Sahni
authors.forename: Julie A
authors.initials: JA
authors.lastname: Boom
authors.forename: Manish M
authors.initials: MM
authors.lastname: Patel
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Baker
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Rench
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007256:Information Systems / Q000706:statistics & numerical data*; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014481:United States; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated