title: Invasive validation of a new oscillometric device (Arteriograph) for measuring augmentation index, central blood pressure and aortic pulse wave velocity.
abstract: BACKGROUND
  The importance of measuring aortic pulse wave velocity (PWVao), aortic augmentation index (Aix) and central systolic blood pressure (SBPao) has been shown under different clinical conditions; however, information on these parameters is hard to obtain. The aim of this study was to evaluate the accuracy of a new, easily applicable oscillometric device (Arteriograph), determining these parameters simultaneously, against invasive measurements.
  
  
  METHODS
  Aortic Aix, SBPao and PWVao were measured invasively during cardiac catheterization in 16, 55 and 22 cases, respectively, and compared with the values measured by the Arteriograph.
  
  
  RESULTS
  We found strong correlation between the invasively measured aortic Aix and the oscillometrically measured brachial Aix on either beat-to-beat or mean value per patient basis (r = 0.9, P < 0.001; r = 0.94, P < 0.001), which allowed the noninvasive calculation of the aortic Aix without using generalized transfer function. Similarly strong correlation (r = 0.95, P < 0.001) was found between the invasively measured and the noninvasively calculated central SBPao; furthermore, the BHS assessment of the paired differences fulfilled the 'B' grading. The PWVao values measured invasively and by Arteriograph were 9.41 ± 1.8 m/s and 9.46 ± 1.8 m/s, respectively (mean ± SD); furthermore, the Pearson's correlation was 0.91 (P < 0.001). The limits of agreement were 11.4% for aortic Aix and 1.59 m/s for PWVao.
  
  
  CONCLUSIONS
  Aix, SBPao and PWVao, measured oscillometrically, showed strong correlation with the invasively obtained values. The observed limits of agreement are encouragingly low for accepting the method for clinical use. Our results suggest that the PWVao values, measured by Arteriograph, are close to the true aortic PWV, determined invasively.
authors.affiliation: aHeart Institute, Medical School, University of Pécs, Pécs, Hungary bDepartment of Cardiology, University of Rome La Sapienza, Polo Pontino, Italy.
authors.forename: Iván G
authors.initials: IG
authors.lastname: Horváth
authors.forename: Adám
authors.initials: A
authors.lastname: Németh
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Lenkey
authors.forename: Nicola
authors.initials: N
authors.lastname: Alessandri
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tufano
authors.forename: Pál
authors.initials: P
authors.lastname: Kis
authors.forename: Balázs
authors.initials: B
authors.lastname: Gaszner
authors.forename: Attila
authors.initials: A
authors.lastname: Cziráki
mesh_terms: D000368:Aged; D000792:Angiography / Q000295:instrumentation / Q000379:methods*; D001011:Aorta / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology; D004548:Elasticity / Q000502:physiology; D005260:Female; D006801:Humans; D006814:Hungary; D007558:Italy; D008297:Male; D008875:Middle Aged; D009991:Oscillometry / Q000295:instrumentation / Q000379:methods*; D012039:Regional Blood Flow / Q000502:physiology*; D015203:Reproducibility of Results