Protective activity of Jiang-Zhi-Li-Gan against carbon tetrachloride-induced hepatic injury in mice.
The administration of carbon tetrachloride (CCl(4)) to mice produced hepatotoxicity, showing a significant increase in the serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST). Mice pretreated with Jiang-Zhi-Li-Gan (JZLG, 100-900 mg/kg, p.o.), a domestic remedy for liver disease in Rui-Jin Hospital, showed a significant decrease in serum ALT and AST levels when compared to the group treated with CCl(4) alone. The standard drug, bifendate (200 mg/kg, p.o.), also exhibited similar results. In the acute toxicity study, JZLG did not show any mortality up to a dose of 32 g/kg body weight. Based on the results obtained, it can be concluded that JZLG seems to possess hepatoprotective activity in mice. These results support the use of this prescription against chemical hepatic injury.
Zhai
Qing
Q
Department of Pharmacy, Fudan University Cancer Hospital, Shanghai, China.
Bian
Xiao-Lan
XL
Yu
Bo
B
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D011897:Random Allocation; D023382:Toxicity Tests, Acute
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; C553648:jiang-zhi-li-gan; D002251:Carbon Tetrachloride