An adult myometrial pluripotential precursor that promotes healing of damaged muscular tissues.
The use of adult stem cells for tissue and organ regeneration constitutes a promising alternative therapy in many human diseases that are currently not treatable. We have isolated a new cell type from mouse adult uterine biopsies (murine adult myometrial precursors or mAMPs) by means of using a simple and non-invasive approach. These cells have been characterized by surface markers, being positive for CD31, CD34, CD44, CD117, Stro-1 and Sca-1. A similar cell population (hAMPs) was isolated from human biopsies. AMPs can differentiate in vitro into a number of mesodermal (smooth and skeletal muscle, osteoblasts and adipocytes) as well as epidermal lineages (all neural lineages). AMPs are unusual adult stem cells as they still express some embryonic antigens and remain undifferentiated through a high number of passages before entering senescence. Importantly, when injected into animal models of muscular disease, AMPs can regenerate new muscle fibers, and promote functional muscular recovery. Moreover, these cells can regenerate the uterine lining after wound healing, reconstructing the uterine muscular architecture. In addition, these cells can form new vessels both in vitro and in vivo. We believe that these cells have superior features to other known adult stem cells and, consequently, their use holds great promise for regenerative medicine, drug development and basic research.
Gálvez
Beatriz G
BG
Projech, Science to Technology, Avenida Eduardo Castro s/n 33290 - Gijón, Spain.
Martín
Nuria San
NS
Salama-Cohen
Patricia
P
Lazcano
Juan José
JJ
Coronado
María José
MJ
Lamelas
María L
ML
Alvarez-Barrientes
Alberto
A
Eiró
Noemí
N
Vizoso
Francisco
F
Rodríguez
Carlos
C
D000328:Adult; D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D002455:Cell Division; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008858:Microscopy, Phase-Contrast; D018482:Muscle, Skeletal / Q000166:cytology / Q000293:injuries* / Q000473:pathology; D009215:Myometrium / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods*; D014599:Uterus / Q000166:cytology / Q000502:physiology; D014945:Wound Healing
D015703:Antigens, CD