title: Detection and treatment of resistant hypertension.
abstract: The evaluation of patients with resistant hypertension should be directed toward confirming true treatment resistance, identifying the causes contributing to treatment resistance (including secondary causes of hypertension), and documenting target-organ damage. Treatment of resistant hypertension is aimed at reversing lifestyle factors contributing to treatment resistance, accurately diagnosing and appropriately treating secondary causes of hypertension, and effectively using multidrug regimens. Lifestyle changes, pharmacologic therapies, and nonpharmacologic therapies have all shown benefits in patients with resistant hypertension, but much additional knowledge is needed to better identify and treat these patients.
authors.affiliation: Hypertension Unit, Hospital 12 de Octubre, Av. Córdoba s/n, 28041, Madrid, Spain. hta@juliansegura.com
authors.forename: Julian
authors.initials: J
authors.lastname: Segura
authors.forename: Alejandro
authors.initials: A
authors.lastname: de la Sierra
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ruilope
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D050197:Atherosclerosis / Q000150:complications; D018660:Blood Pressure Monitoring, Ambulatory / Q000592:standards*; D048909:Diabetes Complications / Q000628:therapy; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000150:complications; D008019:Life Style; D008297:Male; D018673:Nutrition Policy; D009765:Obesity / Q000150:complications / Q000628:therapy; D010353:Patient Education as Topic; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000628:therapy; D017673:Sodium Chloride, Dietary / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D017673:Sodium Chloride, Dietary