The HTR1A and HTR1B receptor genes influence stress-related information processing.
The serotonergic system has been widely implicated in stress related psychiatric disorders such as depression and anxiety. We investigated the possible association between depression and anxiety scores and SNPs within the HTR1A and HTR1B genes in a population sample (n=1387). There was no direct SNP-phenotype association, but in interaction with recent stressful life events rs6295 G, rs878567 T alleles and rs6296 C alleles were associated with significantly higher symptom scores. A subset of control subjects (n=101) took part in a computerised face emotion processing task. Healthy rs6295 GG carriers did not show an affective bias to perceive more negative emotions but reacted more quickly to fearful faces. Thus we conclude that the serotonin-1A receptor conveys vulnerability to these psychiatric disorders by modulating threat-related information processing. Our results extend previous findings of an interaction between stressful life events and the serotonin transporter gene to two other genes in the serotonergic pathway and emphasise the possible role of increased threat-related information processing as an intermediate phenotype.
Mekli
Krisztina
K
Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, UK.
Payton
Antony
A
Miyajima
Fabio
F
Platt
Hazel
H
Thomas
Emma
E
Downey
Darragh
D
Lloyd-Williams
Kathryn
K
Chase
Diana
D
Toth
Zoltan G
ZG
Elliott
Rebecca
R
Ollier
William E
WE
Anderson
Ian M
IM
Deakin
J F William
JF
Bagdy
Gyorgy
G
Juhasz
Gabriella
G
D000328:Adult; D000483:Alleles; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D003071:Cognition; D015331:Cohort Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D003863:Depression / Q000235:genetics* / Q000523:psychology; D004644:Emotions; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013315:Stress, Psychological / Q000235:genetics* / Q000523:psychology; D011795:Surveys and Questionnaires; D055815:Young Adult
C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; D004247:DNA