Behavior of acetyl-L-carnitine injections (Nicetile fiale) with different drugs used for combined therapy.
BACKGROUND
Acetyl-L-carnitine (Nicetile fiale; Biofutura Pharma S.p.A., Sigma Tau group, Milano, Italy) is a compound widely used for the treatment of many diseases, such as neuropathies, diabetic polyneuropathy, and Parkinson's disease. It is frequently administered via the intramuscular route with other drugs, such as steroidal anti.inflammatories, muscle relaxants, and vitamins.


METHODS
In the present study the behavior of acetyl-L-carnitine injections (Nicetile fiale) with different drugs used for combined therapy was studied. Physicochemical properties including color, clarity, pH, and drug content were observed before and after mixing at room temperature.


RESULTS
The content of all the active drugs after mixing remained optimal within 10% of their nominal values.


CONCLUSIONS
The measurements demonstrate the physicochemical compatibility between Nicetile fiale and the other tested products, meaning that there is no evidence of interactions and degradation.
Sinicropi
Maria Stefania
MS
Department of Pharmaceutical Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy. s.sinicropi@unical.it
Leone
Francesco
F
Rovito
Nicola
N
Genchi
Giuseppe
G
D000108:Acetylcarnitine / Q000737:chemistry / Q000493:pharmacokinetics; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001812:Blood-Brain Barrier / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D004338:Drug Combinations; D004339:Drug Compounding / Q000592:standards; D004344:Drug Incompatibility; D004355:Drug Stability; D005938:Glucocorticoids / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D009465:Neuromuscular Agents / Q000737:chemistry; D018697:Nootropic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D014815:Vitamins / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D005938:Glucocorticoids; D009465:Neuromuscular Agents; D018697:Nootropic Agents; D014815:Vitamins; D000108:Acetylcarnitine