title: Solid variant of papillary renal cell carcinoma with spindle cell and tubular components.
abstract: The solid variant of papillary renal cell carcinoma, when strictly defined as a tumor in which no true papillae can be identified, is extremely rare, with only a few cases reported in the literature. This tumor is characterized histologically by solid sheets of cells without true papillae; nevertheless, immunohistochemical and genetic analysis supports the classification of this tumor as a variant of papillary renal cell carcinoma. We report a case of solid variant of papillary renal cell carcinoma affecting a young man and provide histologic and clinical follow-up data, adding an additional case of this extremely rare pathology to the literature. In addition, we describe the first case, to our knowledge, of a solid variant of papillary renal cell carcinoma to contain a high-grade (sarcomatoid) spindle cell component.
authors.affiliation: Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Cantley
authors.forename: Paolo
authors.initials: P
authors.lastname: Gattuso
authors.forename: David
authors.initials: D
authors.lastname: Cimbaluk
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D018572:Disease-Free Survival; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D016896:Treatment Outcome; D014314:Trisomy
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm