title: [Perforation risk and patient age. Risk analysis in acute sigmoid diverticulitis].
abstract: BACKGROUND
  It is often postulated that younger patients with acute sigmoid diverticulitis (SD) have an increased risk of perforation which constitutes an indication for early surgery. The aim of this study was to correlate the severity of sigmoid diverticulitis with patient age in order to check the surgical indication in younger patients.
  
  
  METHODS
  Patients with acute SD from January 1998 to June 2009 were included. Two age groups were distinguished: group I (GI) ≤40 years in age and group II (GII) >40 years. The perforation risk associated with first episode SD was determined by multivariate analysis. SD was classified according to Hansen and Stock (H/S).
  
  
  RESULTS
  In the total cohort of 959 patients, including 86 in GI (8.9%) and 873 in GII (91.1%) 468 had a first episode, with 64 in GI (13.7%) and 404 in GII (86.3%). The proportion of first episodes was 74.4% in GI and 46.3% in GII (p<0.001). The perforation risk did not differ (H/S IIb: 29.7% in GI vs. 29.2% in GII, p=0.938; H/S IIc: 25% in GI vs. 25% in GII, p=1). Treatment regimes were (GI vs. GII) emergency operations 25% vs. 25% (p=1), elective operations 17.2% vs. 10% (p=0.096) and conservative treatment 57.8% vs. 64.9% (p=0.276).
  
  
  CONCLUSIONS
  First episodes of SD were more frequent in younger patients (≤40) and did not involve a higher risk of perforation. The indication for treatment of acute SD should not be based on age but on the severity of inflammation and the individual situation of patients.
authors.affiliation: Klinik für Allgemein-, Gefäß- und Thoraxchirurgie, Chirurgische Klinik I, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany. christoph.holmer@charite.de
authors.forename: C
authors.initials: C
authors.lastname: Holmer
authors.forename: K S
authors.initials: KS
authors.lastname: Lehmann
authors.forename: J
authors.initials: J
authors.lastname: Gröne
authors.forename: H J
authors.initials: HJ
authors.lastname: Buhr
authors.forename: J-P
authors.initials: JP
authors.lastname: Ritz
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D001604:Berlin; D015331:Cohort Studies; D004239:Diverticulitis, Colonic / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D004630:Emergencies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007416:Intestinal Perforation / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012008:Recurrence; D012307:Risk Factors; D012810:Sigmoid Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed