title: Radiologic and near-infrared/optical spectroscopic imaging: where is the synergy?
abstract: OBJECTIVE
  Optical and radiologic imaging are commonly used in preclinical research, and research into combined instruments for human applications is showing promise. The purpose of this article is to outline the fundamental limitations and advantages and to review the available systems. The emerging developments and future potential will be summarized.
  
  
  CONCLUSIONS
  Integration of hybrid systems is now routine at the preclinical level and appears in the form of specialized packages in which performance varies considerably. The synergy is commonly focused on using spatial localization from radiographs to provide structural data for spectroscopy; however, applications also exist in which the spectroscopy informs the use of radiologic imaging. Examples of clinical systems under research and development are shown.
authors.affiliation: Dartmouth College, Hanover, New Hampshire 03755, USA. brian.w.pogue@dartmouth.edu
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Frederic
authors.initials: F
authors.lastname: Leblond
authors.forename: Venkataramanan
authors.initials: V
authors.lastname: Krishnaswamy
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
mesh_terms: D008027:Light; D008853:Microscopy / Q000295:instrumentation*; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation*; D013382:Subtraction Technique / Q000295:instrumentation*; D018511:Systems Integration