Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917.
The beneficial effect of probiotic Escherichia coli strain Nissle 1917 (EcN) suggests the gut epithelium plays a basic role in immune interactions with bacteria. Contrary to other commensal strains of Escherichia coli, EcN profoundly modulates the gut barrier to elevate its resistance to microbial pathogens. The present review documents the properties of EcN that have led to the protection of gnotobiotic pigs against lethal enteric infections. This effect could be important in light of the growing number of acquired deficiencies that paralyze gut immunity in humans.
Trebichavsky
Ilja
I
Division of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic.
Splichal
Igor
I
Rada
Vojtech
V
Splichalova
Alla
A
D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology; D004926:Escherichia coli; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D056747:Immunomodulation / Q000187:drug effects* / Q000276:immunology; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D019936:Probiotics / Q000494:pharmacology*