title: National Heart, Lung, and Blood Institute working group on emergency department management of acute heart failure: research challenges and opportunities.
abstract: This paper details the substance and recommendations arising from a meeting convened by the National Heart, Lung, and Blood Institute in August 2009, to assess the challenges and opportunities of emergency department management of acute heart failure syndrome (AHFS). The assembled faculty represented a large cross section of medical professionals spanning the medical management continuum of patients presenting with acute heart failure and included heart failure cardiologists, emergency physicians, laboratory medicine specialists, nurses, and bench scientists. Their recommendations include proposals regarding the design and conduct of emergency department-based clinical trials, suggestions regarding the development of improved methods for early detection and monitoring of AHFS, and potential needs for expanding translational and applied AHFS focused research and biotechnology. We anticipate that this review will serve as a starting point for future investigations across the spectrum of funding sources.
authors.affiliation: The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. Peacocw@ccf.org
authors.forename: W Frank
authors.initials: WF
authors.lastname: Peacock
authors.forename: Eugene
authors.initials: E
authors.lastname: Braunwald
authors.forename: William
authors.initials: W
authors.lastname: Abraham
authors.forename: Nancy
authors.initials: N
authors.lastname: Albert
authors.forename: John
authors.initials: J
authors.lastname: Burnett
authors.forename: Rob
authors.initials: R
authors.lastname: Christenson
authors.forename: Sean
authors.initials: S
authors.lastname: Collins
authors.forename: Deborah
authors.initials: D
authors.lastname: Diercks
authors.forename: Greg
authors.initials: G
authors.lastname: Fonarow
authors.forename: Judd
authors.initials: J
authors.lastname: Hollander
authors.forename: Art
authors.initials: A
authors.lastname: Kellerman
authors.forename: Mihai
authors.initials: M
authors.lastname: Gheorghiade
authors.forename: Doug
authors.initials: D
authors.lastname: Kirk
authors.forename: Phil
authors.initials: P
authors.lastname: Levy
authors.forename: Alan
authors.initials: A
authors.lastname: Maisel
authors.forename: Barry M
authors.initials: BM
authors.lastname: Massie
authors.forename: Christopher
authors.initials: C
authors.lastname: O'Connor
authors.forename: Peter
authors.initials: P
authors.lastname: Pang
authors.forename: Monica
authors.initials: M
authors.lastname: Shah
authors.forename: George
authors.initials: G
authors.lastname: Sopko
authors.forename: Lynne
authors.initials: L
authors.lastname: Stevenson
authors.forename: Alan
authors.initials: A
authors.lastname: Storrow
authors.forename: John
authors.initials: J
authors.lastname: Teerlink
mesh_terms: D000208:Acute Disease; D002309:Cardiology / Q000191:economics / Q000379:methods* / Q000458:organization & administration; D002986:Clinical Trials as Topic; D004635:Emergency Medicine / Q000191:economics / Q000379:methods* / Q000458:organization & administration; D005544:Forecasting; D006333:Heart Failure / Q000191:economics / Q000628:therapy*; D006439:Hemodynamics; D006801:Humans; D054555:National Heart, Lung, and Blood Institute (U.S.); D009316:National Institutes of Health (U.S.); D017063:Outcome Assessment, Health Care; D012107:Research Design / Q000639:trends; D014481:United States