[Linear IgA bullous dermatosis].
The linear IgA bullous dermatosis can have various aspects involving erythema and bullous lesions. It is a rare disease. Two peaks of frequency are noticed in children before puberty and in adults around 60 years of age. The histological and immunological characterisation is infraepidermal bullous lesions and linear deposits of IgA along the dermoepidermal basement membrane. There are some targets antigens. There is often a medical condition that seems to trigger. The link with drugs in particular with vancomycin was established. The mainstay of treatment is dapsone generally associated with steroids.
Lorette
Gérard
G
Université François-Rabelais (Tours), service de dermatologie, CHU Trousseau, 37044 Tours cedex, France. lorettegerard@yahoo.fr
Georgesco
Gabriella
G
D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003622:Dapsone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D005602:France / Q000453:epidemiology; D006652:Histological Techniques; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D035583:Rare Diseases; D012307:Risk Factors; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D014640:Vancomycin / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D014640:Vancomycin; D003622:Dapsone