Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and treating cancer. We describe here the potential of nanotechnology to fill this gap. Several nutraceuticals, including curcumin, green tea polyphenols, coenzyme Q, quercetin, thymoquinone and others, have been packaged as nanoparticles and proven to be useful in "nanochemoprevention" and "nano-chemotherapy".
Nair
Hareesh B
HB
Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. nairh@uthscsa.edu
Sung
Bokyung
B
Yadav
Vivek R
VR
Kannappan
Ramaswamy
R
Chaturvedi
Madan M
MM
Aggarwal
Bharat B
BB
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D019587:Dietary Supplements; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy; D053758:Nanoparticles; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy*
D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents