Chronic hepatitis B: past, present, and future.
There have been major advances in the field of hepatitis B (HBV) over the last few decades. These advances have resulted in the understanding of the natural history of chronic HBV infection, effective vaccines against the virus, sensitive assays for screening and monitoring of treatment, and effective treatments for viral suppression, all leading to improved outcomes. Debates and controversies remain, however, over the ideal management strategies of patients with chronic hepatitis B. To eradicate HBV, the global community needs to improve current preventive, screening, and treatment strategies.
Lai
Michelle
M
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA. mlai@bidmc.harvard.edu
Liaw
Yun-Fan
YF
D000998:Antiviral Agents / Q000627:therapeutic use; D002353:Carrier State; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000150:complications; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000266:history / Q000517:prevention & control; D006511:Hepatitis B Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000627:therapeutic use; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology; D006526:Hepatitis C / Q000150:complications; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007231:Infant, Newborn; D008103:Liver Cirrhosis / Q000209:etiology / Q000503:physiopathology; D008403:Mass Screening / Q000379:methods / Q000639:trends; D008991:Monitoring, Physiologic / Q000639:trends; D011247:Pregnancy; D011315:Preventive Medicine / Q000379:methods / Q000639:trends*; D016896:Treatment Outcome
D000998:Antiviral Agents; D004279:DNA, Viral; D006511:Hepatitis B Antigens; D017325:Hepatitis B Vaccines