title: Bilateral panuveitis following intravesical BCG immunotherapy for bladder carcinoma.
abstract: OBJECTIVE
  To report a case of bilateral panuveitis following local treatment with Bacille Calmette-Guérin (BCG) immunotherapy for superficial bladder carcinoma.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  A 70-year-old female presented with severe bilateral anterior chamber inflammation 5 days after intravesical BCG instillation. Despite topical steroids and mydriatics, inflammation worsened and bilateral optic nerve swelling developed.
  
  
  RESULTS
  Oral corticosteroids settled the ocular inflammation, and optic nerve function recovered. A trial of steroid cessation caused rebound uveitis, so she remains on maintenance doses of oral corticosteroid.
  
  
  CONCLUSIONS
  Ocular inflammations following BCG therapy for bladder cancer are rare, and little is known about the management of such cases. This is the first report of bilateral panuveitis with optic nerve edema following such treatment.
authors.affiliation: Moorfields Eye Hospital, London, UK.
authors.forename: Gurmit S
authors.initials: GS
authors.lastname: Uppal
authors.forename: Anish N
authors.initials: AN
authors.lastname: Shah
authors.forename: Charalambos M
authors.initials: CM
authors.lastname: Tossounis
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Tappin
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D009184:Mydriatics / Q000627:therapeutic use; D015864:Panuveitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D001500:BCG Vaccine; D009184:Mydriatics; D003907:Dexamethasone; D011239:Prednisolone