title: [Mechanism of laparoscopic adjustable gastric banding in the treatment of obesity with type 2 diabetes mellitus].
abstract: OBJECTIVE
  To explore the mechanism of laparoscopic adjustable gastric banding (LAGB) in the treatment of obese patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A total of 20 patients with obesity and T2DM were treated with LAGB. During the postoperative 1, 3, 6, 9, 12 months, the body weight changes were monitored and body mass indices (BMI) were calculated. The serum levels of leptin, GLP-1, and ghrelin were examined preoperatively and 1, 3, 6, 9, 12 months after LAGB using enzyme-linked-immunosorbent assay (ELISA). At the same time, the fasting serum insulin (FINS), C-peptide, glycated hemoglobin (HbA1c) levels were examined by electrochemiluminescence and the level of fasting blood glucose (FBG) was tested with oxidase test.
  
  
  RESULTS
  At postoperatively 12 months, all the 20 patients lost weight. The mean body weight decreased from (108 + or - 18) kg to (71 + or - 16) kg (P<0.05) and BMI decreased from 38 + or - 5 to 29 + or - 6 (P<0.05). The HOMA-IR decreased from (12.8 + or - 7.4) to (3.4 + or - 2.0) (P<0.01). The serum ghrelin level increased from (7.8 + or - 1.9) microg/L to (11.6 + or - 2.6) microg/L (P<0.01). The serum leptin level declined from (24.9 + or - 13.7) microg/L to(12.9 + or - 5.1) microg/L (P<0.01). The serum GLP-1 level increased from (0.58 + or - 0.12) microg/L to(0.80 + or - 0.06) microg/L (P<0.01). After LAGB, there were positive correlations between serum leptin level and FBG, FINS, HbA1c,and C-peptide level. Serum ghrelin and GLP-1 were negatively correlated with FBG, FINS, HbA1c,C-peptide.
  
  
  CONCLUSIONS
  LAGB is effective in treatment of obesity patients with T2DM. The mechanism may be associated with the increase of serum GLP-1 and ghrelin and the decrease of serum leptin and insulin resistance.
authors.affiliation: Center of Laparoscopic Surgery, Department of Hepatobiliary Surgery, PLA 309 Hospital, Beijing 100091, China.
authors.forename: Zhao-tao
authors.initials: ZT
authors.lastname: Jiang
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Zou
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.forename: Xin
authors.initials: X
authors.lastname: Dai
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000601:surgery*; D005260:Female; D015391:Gastroplasty / Q000379:methods; D054439:Ghrelin / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000601:surgery*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D054439:Ghrelin; D052216:Glucagon-Like Peptide 1; D006442:Glycated Hemoglobin; D020738:Leptin; C517652:hemoglobin A1c protein, human