Calcium and energy: making the cake and eating it too?
Mitochondrial calcium ions promote a number of events that sustain ATP levels in the cell. Cardenas et al. (2010) now demonstrate that the inositol 1,4,5-triphosphate receptor at the endoplasmic reticulum constitutively provides calcium for mitochondria. In the absence of this calcium transfer, cells use autophagy to sustain survival.
Green
Douglas R
DR
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 92105, USA. douglas.green@stjude.org
Wang
Ruoning
R