[Angiogenesis in cartilage tumors].
In contrast to normal cartilage, which is avascular, angiogenesis is characteristic of cartilage tumors. In this review, we outline the basic principles of angiogenesis with regard to recent findings on differential morphological and molecular aspects of angiogenesis in cartilage tumors, including enchondromas, conventional chondrosarcomas and dedifferentiated chondrosarcomas. Furthermore, we describe the effects of hypoxia and interleukin-1β on angiogenic signaling in chondrosarcoma cells.
Kalinski
T
T
Institut für Pathologie, Otto-von-Guericke-Universität, Leipziger Str. 44, 39120 Magdeburg. kalinski@med.ovgu.de
Roessner
A
A
D001859:Bone Neoplasms / Q000098:blood supply* / Q000473:pathology*; D002356:Cartilage / Q000098:blood supply*; D002357:Cartilage Diseases / Q000473:pathology*; D015687:Cell Hypoxia / Q000502:physiology; D002812:Chondroma / Q000098:blood supply* / Q000473:pathology*; D002813:Chondrosarcoma / Q000098:blood supply* / Q000473:pathology*; D006801:Humans; D053583:Interleukin-1beta / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D053583:Interleukin-1beta; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A