title: Therapeutic time window of low-frequency stimulation at entorhinal cortex for amygdaloid-kindling seizures in rats.
abstract: The present study was designed to determine whether low-frequency stimulation (LFS) of the entorhinal cortex(EC) has an anticonvulsive effect, and whether LFS delivered at different times plays different roles. We found that LFS of the EC immediately or 4 s after kindling stimulation had an anticonvulsive effect, and that the latter had a better effect on both kindling and kindled seizures. However, LFS delivered after the cessation of afterdischarge or 10 s after the kindling stimulation, augmented the epileptic activity. So the EC is a potential target for LFS to interfere with epilepsy. Our findings suggest that even in the duration of afterdischarge, there exists a "time window" for LFS treatment, indicating that the time delay of closed-loop stimulation is crucial for LFS treatment.
authors.affiliation: Institute of Neuroscience, Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Zheng-Hao
authors.initials: ZH
authors.lastname: Xu
authors.forename: Deng-Chang
authors.initials: DC
authors.lastname: Wu
authors.forename: Qi
authors.initials: Q
authors.lastname: Fang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhong
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Hong-Liu
authors.initials: HL
authors.lastname: Sun
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D046690:Deep Brain Stimulation / Q000379:methods; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D004599:Electric Stimulation Therapy / Q000379:methods; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000706:statistics & numerical data; D018728:Entorhinal Cortex / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D007839:Functional Laterality / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology* / Q000517:prevention & control*; D013997:Time Factors