title: [Advances of researches in the pathogenesis of severe hepatitis B].
abstract: Severe hepatitis B is an infectious disease which has high case fatality rate and is seriously harmful to human health. Its pathogenesis is complicated. In this article are reviewed the research reports on the virus and the host factors in the course of severe hepatitis B in recent years, including the advancement of researches on viral genotypes, viral mutations, immune responses and cytokines. These data are available for exploring the pathogenesis and for developing the clinical treatment of severe hepatitis B in future.
authors.affiliation: The Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D009154:Mutation
chemical_list: D016207:Cytokines