Inward rotating spiral waves in glycolysis.
We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account.
Straube
Ronny
R
Max-Planck-Institute for Dynamics of Complex Technical Systems, Systems Biology Group, Sandtorstr. 1, Magdeburg, Germany. rstraube@mpi-magdeburg.mpg.de
Vermeer
Satenik
S
Nicola
Ernesto M
EM
Mair
Thomas
T
D000494:Allosteric Regulation; D004058:Diffusion; D005656:Fungal Proteins / Q000378:metabolism; D006019:Glycolysis; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D025221:Phosphofructokinases / Q000378:metabolism; D012399:Rotation; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000378:metabolism
D005656:Fungal Proteins; D009243:NAD; D025221:Phosphofructokinases