title: Salivary flow rate in patients with schizophrenia on clozapine.
abstract: OBJECTIVE
  To assess the change in salivary flow rate in patients with schizophrenia on clozapine and whether the change in salivary flow rate was dose related.
  
  
  METHODS
  Twenty male inpatients with a diagnosis of schizophrenia according to the International Statistical Classification of Diseases, 10th Revision diagnostic criteria for research who were started on clozapine were recruited for the study. Unstimulated salivary flow rate was assessed at baseline and then weekly for 4 weeks using cotton swab method in 17 patients.
  
  
  RESULTS
  Repeated-measures analysis of variance showed a significant increase in salivary flow rate over time (F [2.37/37.94] = 3.134, P = 0.047, Greenhouse-Geisser correction, eta = 0.16). Also, there was a significant increase in salivary flow rate between weeks 2 and 3 (P < 0.05). There was no correlation between salivary flow rate and mean clozapine dose.
  
  
  CONCLUSIONS
  There was a significant increase in salivary flow rate from baseline after starting clozapine, with a significant increase from the second to the third week followed by a "plateau."
authors.affiliation: Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand-834 006, India. samirpsyche@yahoo.co.in
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Praharaj
authors.forename: Amlan Kusum
authors.initials: AK
authors.lastname: Jana
authors.forename: Kausik
authors.initials: K
authors.lastname: Goswami
authors.forename: Poonam R
authors.initials: PR
authors.lastname: Das
authors.forename: Nishant
authors.initials: N
authors.lastname: Goyal
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Sinha
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012472:Salivation / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012798:Sialorrhea / Q000139:chemically induced; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine