Case of polyhydramnios complicated by Opitz G/BBB syndrome.
Opitz G/BBB syndrome is a congenital disorder characterized by midline defects, such as hypertelorism, cleft lip and/or palate, hypospadias, and by dysphagia often caused by laryngo-tracheo-esophageal abnormalities. We experienced a case of polyhydramnios in a male dichorionic diamniotic (DD) twin, who was diagnosed with Opitz G/BBB syndrome after birth. It is suggested that severe dysphagia was causatively associated with the development of polyhydramnios. In cases of Opitz G/BBB syndrome, boys are usually more heavily affected than girls, who generally manifest only hypertelorism. In the differential diagnosis of polyhydramnios of unidentified cause in male fetuses, it may be helpful to consider maternal facial characteristics, especially hypertelorism.
Tajima
Hiroko
H
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Itoh
Hiroaki
H
Mochizuki
Ayako
A
Nakamura
Yuki
Y
Kobayashi
Yukiko
Y
Hirai
Kyuya
K
Suzuki
Kazunao
K
Sugihara
Kazuhiro
K
Ohishi
Akira
A
Ohzeki
Takehiko
T
Kanayama
Naohiro
N
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002972:Cleft Palate / Q000235:genetics*; D005260:Female; D006801:Humans; D006972:Hypertelorism / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D006831:Polyhydramnios / Q000175:diagnosis* / Q000235:genetics; D011247:Pregnancy; D013577:Syndrome