title: Immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions.
abstract: In different tumor entities, expression of the chemokine receptor 4 (CXCR4) has been linked to tumor dissemination and poor prognosis. The aim of this study was to examine the immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions. Using monoclonal anti-CXCR4 antibody, we performed immunohistochemical staining on tissue sections from 134 cases obtained from Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine (Shanghai, China) between 2000 and 2007. In our study, the CXCR4 expression of the thyroid carcinoma group (including 16 papillary thyroid carcinomas, 18 follicular thyroid carcinomas, 9 poorly differentiated thyroid carcinomas, and 7 medullary thyroid carcinomas) was found to be higher than in the benign lesion group (including 19 cases of Hashimoto's thyroiditis, 15 nodular goiters, and 50 follicular adenomas) (p<0.0001). Within the carcinoma group, the more malignant thyroid carcinoma group (including 9 poorly differentiated thyroid carcinomas and 7 medullary thyroid carcinomas) showed a higher ratio of CXCR4 positivity compared to the less malignant thyroid carcinoma group (including 16 papillary thyroid carcinomas and 18 follicular thyroid carcinomas) (p<0.0001). Our study suggests that CXCR4 expression might be a frequent and cancer-specific event in thyroid carcinoma, and it might be involved in malignancy transformation during the progression of thyroid carcinoma.
authors.affiliation: Laboratory Endocrine & Metabolic Diseases of Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai 200025, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Xiao
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Jin
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Zhu
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D018263:Adenocarcinoma, Follicular; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma; D018278:Carcinoma, Neuroendocrine; D002291:Carcinoma, Papillary; D002454:Cell Differentiation; D002648:Child; D005260:Female; D006044:Goiter, Nodular / Q000276:immunology; D050031:Hashimoto Disease / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019718:Receptors, CXCR4 / Q000032:analysis*; D000077273:Thyroid Cancer, Papillary; D013959:Thyroid Diseases / Q000276:immunology* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000276:immunology / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C527276:CXCR4 protein, human; D019718:Receptors, CXCR4