[Effect of the ethanol extract of Picrorhiza scrophulariiflora on the progression of chronic kidney disease in a rat remnant kidney model].
OBJECTIVE
To investigate the effect of the ethanol extract of Picrorhiza scrophulariiflora (EPS) on renal function and tissue damage in a rat remnant kidney model.


METHODS
Rat models of chronic kidney disease induced by 5/6 nephrectomy (5/6 Nx) were randomly assigned into two groups for treatment with a gavage of either EPS or vehicle for 9 weeks. The rats in the control group received only sham operation.


RESULTS
Compared with vehicle-treated 5/6 Nx rats, the EPS-treated rats displayed significantly decreased urinary excretion of malondialdehyde, serum levels of AGEs and AOPPs, and increased serum SeGSHPx activities. These changes were associated with attenuated urinary protein excretion, glomerular sclerosis and interstitial fibrosis.


CONCLUSIONS
EPS can obviously improve the renal functions and renal pathologies in rats with chronic kidney disease probably by inhibiting the oxidative stress.
Feng
Jian-xun
JX
Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengjx9101 @sina.com
Li
Hong-Yan
HY
Liu
Zhi-qiang
ZQ
Zhou
Zhan-mei
ZM
Tian
Jian-wei
JW
Liang
Min
M
D000818:Animals; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009392:Nephrectomy; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D032261:Picrorhiza / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000473:pathology*
D004365:Drugs, Chinese Herbal