title: [Electroporation and its application].
abstract: Electroporation (EP) is a modern and versatile method that allows the penetration of macromolecules from the intercellular space into cells by forming the channels, under the influence of electromagnetic field. In addition to natural channels and pumps, building cell membranes, resulting electropores an additional way for the transport of macromolecules. The use of this phenomenon has brought good results as a complement to traditional therapeutic methods of treatment during application of cytostatics. EP combination with chemotherapy has reduced the need for surgical intervention (rescue authority). Electroporation is particularly useful for cancer with multidrug resistance, where the dose that enters the interior of cancer cells is limited. Electroporation was also used in transfection of nucleic acids, in photodynamic therapy, cosmetology, as well as the consolidation of the food.
authors.affiliation: Akademia Medyczna we Wroclawiu, Katedra i Zakład Biochemii Lekarskiej. nina.skolucka@gmail.com
authors.forename: Nina
authors.initials: N
authors.lastname: Skołucka
authors.forename: Jolanta
authors.initials: J
authors.lastname: Saczko
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kotulska
authors.forename: Julita
authors.initials: J
authors.lastname: Kulbacka
authors.forename: Anna
authors.initials: A
authors.lastname: Choromańska
mesh_terms: D000818:Animals; D003357:Cosmetic Techniques; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D018274:Electroporation / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D010778:Photochemotherapy / Q000379:methods