title: Successful treatment of dwarfism secondary to long-term steroid therapy in steroid-dependent nephrotic syndrome.
abstract: Prolonged steroid therapy is generally used for steroid-dependent nephrotic syndrome in pediatric patients. However, dwarfism secondary to a long-term regimen and its successful reverse is rarely reported. The underlying mechanism of dwarfism is still poorly understood, as both long-term steroid use and nephrotic syndrome may interact or independently interfere with the process of growth. Here, we present a 17-year-old patient with dwarfism and steroid-dependent nephrotic syndrome and the successful treatment by recombinant human growth factor and cyclosporine A with withdrawal of steroid. We also briefly review the current understanding and the management of dwarfism in pediatric patients with nephrotic syndrome.
authors.affiliation: Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Sun
authors.forename: Dongping
authors.initials: D
authors.lastname: Chen
authors.forename: Xuezhi
authors.initials: X
authors.lastname: Zhao
authors.forename: Chenggang
authors.initials: C
authors.lastname: Xu
authors.forename: Changlin
authors.initials: C
authors.lastname: Mei
mesh_terms: D000293:Adolescent; D016572:Cyclosporine / Q000008:administration & dosage; D004392:Dwarfism / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy*; D005500:Follow-Up Studies; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D016572:Cyclosporine; D011241:Prednisone