Tourette syndrome: gene expression as a tool to discover drug targets.
Gene expression microarrays are a high-throughput, cost-effective method for measuring the expression of all genes in a sample. By comparing the expression patterns of healthy controls to diseased subjects, the genetic regulatory pathways underlying and affected by the disease can be elucidated. Furthermore, dysregulated genes are possible candidates for pharmaceutical therapy. Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology.
Liao
Isaac H
IH
Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA. ihliao@ucdavis.edu
Sharp
Frank R
FR
D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000235:genetics*