title: When the first antiepileptic drug fails in a patient with juvenile myoclonic epilepsy.
abstract: Juvenile myoclonic epilepsy is one of the most common types of epilepsy seen in an adult epilepsy clinic. Most patients have a good prognosis, particularly when treated with valproate, but a significant minority are more difficult to treat. In this article, we will focus on a management strategy when the initial antiepileptic drug is unsuccessful and outline an approach that translates directly to the clinic.
authors.affiliation: The Walton Centre NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK. andrew.nicolson@thewaltoncentre.nhs.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Nicolson
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Marson
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002985:Clinical Protocols; D019468:Disease Management; D004351:Drug Resistance / Q000502:physiology*; D006801:Humans; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D000927:Anticonvulsants