title: Intestinal type adenocarcinoma of the ethmoid sinus in wood and leather workers: a retrospective study of 153 cases.
abstract: BACKGROUND
  The purpose of our study was to identify the role of work exposure to organic dusts in patients with malignant paranasal sinus tumors.
  
  
  METHODS
  We analyzed all patients surgically treated for a malignant paranasal sinus tumor at our institution between 1987 and 2006. All patients were specifically asked about their occupational history. The tumor site was classified as maxillary or ethmoid sinus. Adenocarcinomas were divided into intestinal type (ITAC) and non-ITAC.
  
  
  RESULTS
  The sample included 345 patients with ethmoid sinus and 301 maxillary sinus. Regarding the ethmoid sinus, we found an exposure to organic dusts in 148 of 153 patients with ITAC, in 3 of 16 patients with non-ITAC adenocarcinoma, and in 10 of 176 patients with other tumors. Regarding the maxillary sinus, we found an exposure in 1 of 20 patients with non-ITAC adenocarcinoma and in 4 of 281 patients with other histologies.
  
  
  CONCLUSIONS
  Our study demonstrates that only ethmoid ITACs have an indisputable relationship with the exposure to organic dusts.
authors.affiliation: Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milan, Italy. giulio.cantu@istitutotumori.mi.it
authors.forename: Giulio
authors.initials: G
authors.lastname: Cantu
authors.forename: Carlo L
authors.initials: CL
authors.lastname: Solero
authors.forename: Luigi
authors.initials: L
authors.lastname: Mariani
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lo Vullo
authors.forename: Stefano
authors.initials: S
authors.lastname: Riccio
authors.forename: Sarah
authors.initials: S
authors.lastname: Colombo
authors.forename: Madia
authors.initials: M
authors.lastname: Pompilio
authors.forename: Federica
authors.initials: F
authors.lastname: Perrone
authors.forename: Paolo
authors.initials: P
authors.lastname: Formillo
authors.forename: Pasquale
authors.initials: P
authors.lastname: Quattrone
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000401:mortality / Q000473:pathology; D004391:Dust; D005005:Ethmoid Sinus; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D014934:Wood
chemical_list: D004391:Dust