title: Independent influence of dietary protein on markers of kidney function and disease in obesity.
abstract: Obesity is associated with glomerular hyperfiltration and increased urinary protein excretion, as well as structural and functional changes that lead to kidney disease and failure. Dietary protein mimics obesity's effects on the glomerular filtration rate (GFR) and proteinuria and, in certain circumstances, may have the potential to adversely affect kidney function. Here we tested the hypothesis that dietary protein independently explains elevations in the GFR and proteinuria found in obese persons with a normal serum creatinine. Seventeen patients were randomized in a double-blind, crossover fashion for 1-week periods to high (140 g/day) and low (50 g/day) protein diets with a 1-week washout interval separating these periods. High protein consumption was associated with a very modest but significant increase in the GFR of 5 ± 6 ml/min. Hence, while dietary protein does modulate kidney parameters, it is unlikely to fully account for the elevations in GFR and proteinuria found in obesity.
authors.affiliation: Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. allfried@iupui.edu
authors.forename: Allon N
authors.initials: AN
authors.lastname: Friedman
authors.forename: Zhangsheng
authors.initials: Z
authors.lastname: Yu
authors.forename: Beth E
authors.initials: BE
authors.lastname: Juliar
authors.forename: James T
authors.initials: JT
authors.lastname: Nguyen
authors.forename: Matthew
authors.initials: M
authors.lastname: Strother
authors.forename: Sara K
authors.initials: SK
authors.lastname: Quinney
authors.forename: Lang
authors.initials: L
authors.lastname: Li
authors.forename: Margaret
authors.initials: M
authors.lastname: Inman
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gomez
authors.forename: Zak
authors.initials: Z
authors.lastname: Shihabi
authors.forename: Sharon
authors.initials: S
authors.lastname: Moe
mesh_terms: D000328:Adult; D015415:Biomarkers; D018592:Cross-Over Studies; D004044:Dietary Proteins / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D004044:Dietary Proteins