The chemical biology of synapses and neuronal circuits.
Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have important biological consequences. Powerful chemical biological techniques have now been developed to decipher the dynamic stability of the synapses and to further interrogate the complex properties of neuronal circuits.
Bito
Haruhiko
H
Department of Neurochemistry at University of Tokyo Graduate School of Medicine, Tokyo, Japan. hbito@m.u-tokyo.ac.jp
D000818:Animals; D001671:Biochemistry; D049229:Dendritic Spines / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009434:Neural Pathways / Q000737:chemistry* / Q000502:physiology*; D013569:Synapses / Q000737:chemistry* / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology