[Thrombotic microangiopathy following kidney transplantation revealing factors H and I deficiencies].
A 52-year-old man with an end stage renal failure of undetermined aetiology was hemodialysed in 2002. He received a cadaveric kidney transplantation in 2004. After an episode of diarrhea, a thrombotic microangiopathy was diagnosed in July 2009 and during this episode, a low C3 serum level was identified. Plasma exchanges were beneficial. Exploration of the low C3 serum level revealed both factor H and factor I deficiencies. We think that the renal failure of undetermined aetiology was probably an unnoticed haemolytic and uremic syndrome which recurred more than five years after transplantation.
Fraison
J-B
JB
Service de médecine interne, centre hospitalier de Béziers, 2 rue Valentin-Hauÿ, Béziers, France. jbfraison@gmail.com
Pernin
V
V
Alméras
C
C
Vetromile
F
F
Frémeaux-Bacchi
V
V
Mourad
G
G
D017242:Complement Factor H / Q000172:deficiency*; D017244:Complement Factor I / Q000172:deficiency*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D057049:Thrombotic Microangiopathies / Q000209:etiology*
D017242:Complement Factor H; D017244:Complement Factor I