title: Modeling of the in vivo kinetics of antioxidants delineates suitable parameters for selecting potential antioxidant adjuvants for cancer therapy.
abstract: To find in vivo behaviors of an antioxidant when used as an adjuvant cancer therapy, a more detailed integrated pharmacokinetic scheme is needed. Major reaction parameters associated with the sequential routes from ingestion to decay of an antioxidant were used in mathematical analysis, which included absorption rate coefficient k(a), quenching rate coefficient of the antioxidant k(q1) and tissue quenching rate coefficient k(r). The model was then treated with computer simulation using cited decay rate coefficients and some assumed parameters. When intestinal absorption rate coefficient k(a) becomes larger, retention time of antioxidant in plasma would be prolonged. moreover, k(a) had no effect on either quenching ability of antioxidants or tissue recovering capability. in quenching plasma ROS, the larger the quenching coefficient k(q1), the shorter peak- and the life-times would be for the secondary free radicals that are formed in primary quenching. Conclusively, it is suggestive to prescribe an antioxidant therapy with an appropriate values of k(a) and larger values of k(q1).
authors.affiliation: Department of Food and Nutrition, Hungkuang University, Shalu County, Taichung Hsien, Taiwan.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Chao-Ming
authors.initials: CM
authors.lastname: Chuang
authors.forename: Chiu-Lan
authors.initials: CL
authors.lastname: Hsieh
authors.forename: Hui-Er
authors.initials: HE
authors.lastname: Wang
authors.forename: Kuan-Chou
authors.initials: KC
authors.lastname: Chen
authors.forename: Wen-Ta
authors.initials: WT
authors.lastname: Chiu
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Shih
authors.forename: Robert Y
authors.initials: RY
authors.lastname: Peng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002338:Carotenoids / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D000529:Complementary Therapies; D003198:Computer Simulation; D019587:Dietary Supplements; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D000077276:Lycopene; D008353:Mannitol / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D008954:Models, Biological; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*; D017382:Reactive Oxygen Species / Q000097:blood / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species; D002338:Carotenoids; D008353:Mannitol; D000077276:Lycopene