title: Haematology and serum chemistry of Pyrenean chamois (Rupicapra pyrenaica) naturally infected with a border disease virus.
abstract: In 2005 and 2006 an outbreak of disease associated with border disease virus (BDV) infection caused high mortality in the Pyrenean chamois (Rupicapra pyrenaica) in the Catalan Pyrenees (NE Spain). The aim of this study was to determine values for different haematological and serum biochemical analytes in 32 free-ranging Pyrenean chamois affected by the disease and to compare them with those obtained from healthy chamois. In the affected chamois red blood cell counts, haemoglobin concentrations, packed cell volumes, mean corpuscular volumes and lymphocyte counts were all lower, while the neutrophil and platelet counts were higher. Glucose, lactate, triglycerides, creatinine, total protein concentrations and alkaline phosphatase activity were also lower, in contrast to the concentrations of total bilirubin, urea and aspartate aminotransferase activity, which were higher. Most of the observed changes could be associated with cachexia and inflammation in the affected chamois. Lymphopenia could be directly related to the BDV, which would lead to immunosuppression and explain the high rate of secondary infection observed in these animals.
authors.affiliation: Servei d'Ecopatologia de Fauna Salvatge, Facultat de Veterinaria, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. laura@montx.com
authors.forename: L
authors.initials: L
authors.lastname: Fernández-Sirera
authors.forename: G
authors.initials: G
authors.lastname: Mentaberre
authors.forename: J R
authors.initials: JR
authors.lastname: López-Olvera
authors.forename: R
authors.initials: R
authors.lastname: Cuenca
authors.forename: S
authors.initials: S
authors.lastname: Lavín
authors.forename: I
authors.initials: I
authors.lastname: Marco
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D001882:Border Disease / Q000097:blood*; D018083:Border disease virus; D003404:Creatinine / Q000097:blood; D004906:Erythrocyte Count / Q000662:veterinary; D004909:Erythrocyte Indices / Q000662:veterinary; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007773:Lactates / Q000097:blood; D018655:Lymphocyte Count / Q000662:veterinary; D048608:Rupicapra / Q000097:blood / Q000821:virology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D006454:Hemoglobins; D007773:Lactates; D014280:Triglycerides; D003404:Creatinine; D001219:Aspartate Aminotransferases; D001663:Bilirubin