Rationale for cross-species infection and cross-subtype mutation in hemagglutinins from influenza A virus.
The current H1N1 swine pandemic raises the question why the cross-species infection and cross-subtype mutation are so easy. In this study, we use ANOVA to analyze all influenza A virus hemagglutinins available in database in order to answer this question. The results show that there are differences between species and between subtypes in most cases, but the intra-subtype/species variation is generally larger than the inter-subtype/species variation, which provides the rational for cross-species infection and cross-subtype mutation.
Yan
Shao-Min
SM
National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, P.R. China.
Wu
Guang
G
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D001717:Birds; D004196:Disease Outbreaks; D014644:Genetic Variation; D006388:Hemagglutinins / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D009980:Influenza A virus / Q000235:genetics*; D005585:Influenza in Birds / Q000821:virology; D007251:Influenza, Human / Q000821:virology; D008957:Models, Genetic; D009154:Mutation; D015203:Reproducibility of Results; D013045:Species Specificity
D000596:Amino Acids; D006388:Hemagglutinins