title: Vesiculopustular eruption in a neonate with trisomy 21 syndrome as a clue of transient myeloproliferative disorders.
abstract: We report the case of a vesiculopustular eruption associated with a transient myeloproliferative disorder (TMD) in a neonate with trisomy 21 syndrome. Examination of a skin biopsy showed a dermal mixed inflammatory infiltrate including atypical megakaryoblasts. As the white blood cell count spontaneously normalized, the eruption disappeared. This case report and review of the literature demonstrates that a vesiculopustular eruption could be an important clue to identify TMD in a neonate.
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Piersigilli
authors.forename: Andrea
authors.initials: A
authors.lastname: Diociaiuti
authors.forename: Renata
authors.initials: R
authors.lastname: Boldrini
authors.forename: Cinzia
authors.initials: C
authors.lastname: Auriti
authors.forename: Marco
authors.initials: M
authors.lastname: Curci
authors.forename: Maya
authors.initials: M
authors.lastname: El Hachem
authors.forename: Giulio
authors.initials: G
authors.lastname: Seganti
mesh_terms: D001706:Biopsy; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D055016:Megakaryocyte Progenitor Cells / Q000378:metabolism; D009196:Myeloproliferative Disorders / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology