title: Effect of chronic intake of arsenic-contaminated water on blood oxidative stress indices in cattle in an arsenic-affected zone.
abstract: This study aimed to determine the hemato-biochemical picture and blood oxidative stress in zebu cattle in an arsenic-contaminated zone. Significant decline in total erythrocyte count, packed cell volume, and total plasma protein was observed in cattle of that area in comparison to uncontaminated zone. There was significant elevation of plasma enzyme activities of both alanine aminotransaminase and aspertate aminotransaminase. Increased corpuscular osmotic fragility also proved to be a mechanism for deviation from normal functioning of erythrocytes. Cattle in the affected zone showed a significantly higher arsenic burden in blood. Those animals further showed decreased superoxide dismutase, catalase activities of erythrocytes, and plasma nitrite level, but increased lipid peroxidation and protein carbonyl level. Our finding concluded that cattle of the arsenic-contaminated zone is suffering from a subclinical form of arsenic toxicity, which is proved through altered hemato-biochemical indices and a certain extent of oxidative stress with higher arsenic concentration in blood.
authors.affiliation: Indian Veterinary Research Institute, Eastern Regional Station, 37, Belgachia Road, Kolkata 700 037, India.
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Rana
authors.forename: Asit Kumar
authors.initials: AK
authors.lastname: Bera
authors.forename: Subhashree
authors.initials: S
authors.lastname: Das
authors.forename: Debasis
authors.initials: D
authors.lastname: Bhattacharya
authors.forename: Subhasish
authors.initials: S
authors.lastname: Bandyopadhyay
authors.forename: Diganta
authors.initials: D
authors.lastname: Pan
authors.forename: Subrata
authors.initials: S
authors.lastname: Kumar Das
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001151:Arsenic / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000097:blood* / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000201:enzymology / Q000378:metabolism; D004326:Drinking; D004912:Erythrocytes / Q000201:enzymology; D007194:India; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000097:blood / Q000633:toxicity*
chemical_list: D001798:Blood Proteins; D014874:Water Pollutants, Chemical; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001151:Arsenic