title: Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
abstract: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
authors.affiliation: School of Public Health, University of California, Berkeley, Berkeley, California, USA.
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authors.lastname: Conde
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authors.lastname: Halperin
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authors.forename: Katja
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authors.lastname: de Sanjosé
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authors.lastname: Staines
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authors.lastname: Camp
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authors.lastname: Glenn
authors.forename: Neil E
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authors.lastname: Caporaso
authors.forename: James R
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authors.lastname: Cerhan
authors.forename: Julie M
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authors.lastname: Cunningham
authors.forename: Lynn R
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authors.lastname: Goldin
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authors.lastname: Hanson
authors.forename: Neil E
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authors.forename: Mark C
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authors.forename: Jose F
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authors.lastname: Leis
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authors.initials: GE
authors.lastname: Marti
authors.forename: Kari G
authors.initials: KG
authors.lastname: Rabe
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authors.initials: LZ
authors.lastname: Rassenti
authors.forename: Logan G
authors.initials: LG
authors.lastname: Spector
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authors.lastname: Strom
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authors.lastname: Vachon
authors.forename: J Brice
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authors.lastname: Weinberg
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authors.initials: EA
authors.lastname: Holly
authors.forename: Stephen
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authors.lastname: Chanock
authors.forename: Martyn T
authors.initials: MT
authors.lastname: Smith
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Christine F
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authors.lastname: Skibola
mesh_terms: D004198:Disease Susceptibility; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D008224:Lymphoma, Follicular / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics; D008285:Major Histocompatibility Complex; D012307:Risk Factors