title: Descriptive no more: the dawn of high-throughput microscopy.
abstract: The next revolution in microscopy is upon us: it is High-Throughput Imaging (HTI). In HTI large numbers of images from many samples are acquired and analyzed. This has become possible due to a confluence of dramatic progress in microscope engineering, enabling efficient image collection, and the availability of high computing power for data analysis. Combining HTI with genome-wide RNA interference (RNAi)-based gene knockdown technology offers a powerful approach for unbiased discovery of cellular mechanisms.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Roukos
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
authors.forename: Christine K
authors.initials: CK
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D003584:Cytological Techniques / Q000379:methods*; D006801:Humans; D008853:Microscopy / Q000379:methods*