title: Randomised comparison of percutaneous left ventricular assist device with open-chest cardiac massage and with surgical assist device during ischaemic cardiac arrest.
abstract: OBJECTIVE
  A percutaneous left ventricular assist device can maintain blood flow to vital organs during ventricular fibrillation and may improve outcomes in ischaemic cardiac arrest. We compared haemodynamic and clinical effects of a percutaneous left ventricular assist device with a larger device deployed via endovascular prosthesis and with open-chest cardiac massage during ischaemic cardiac arrest.
  
  
  METHODS
  Eighteen swine were randomised into three groups. After thoracotomy, coronary ischaemia and ventricular fibrillation was induced. Cardiac output was measured with transit-time flowmetry. Tissue perfusion was measured with microspheres. Defibrillation was performed after 20 min.
  
  
  RESULTS
  Cardiac output with cardiac massage was 1129 mL min⁻¹ vs. 1169 mL min⁻¹ with the percutaneous- and 570 mL min⁻¹ with the surgical device (P < 0.05 surgical vs. others). End-tidal CO₂ was 3.3 kPa with cardiac massage vs. 3.2 kPa with the percutaneous- and 2.3 kPa with the surgical device (P < 0.05 surgical vs. others). Subepicardial perfusion was 0.33 mL min⁻¹ g⁻¹ with cardiac massage vs. 0.62 mL min⁻¹ g⁻¹ with both devices (P < 0.05 devices vs. massage), cerebral perfusion was comparable between groups (all reported values after 3 min cardiac arrest, all P<0.05 vs. baseline, all P = NS for 3 min vs. 15 min). Return of spontaneous circulation was achieved in 5/6 subjects with cardiac massage vs. 6/6 with the percutaneous- and 4/6 with the surgical device (P = NS).
  
  
  CONCLUSIONS
  The percutaneous device improved myocardial perfusion, maintained cerebral perfusion and systemic circulation with similar rates of successful defibrillation vs. cardiac massage. Increased delivery was not obtained with the surgical device during cardiac arrest.
authors.affiliation: Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei, N-5021 Bergen, Norway. vegard.tuseth@helse-bergen.no
authors.forename: V
authors.initials: V
authors.lastname: Tuseth
authors.forename: R J
authors.initials: RJ
authors.lastname: Pettersen
authors.forename: K
authors.initials: K
authors.lastname: Grong
authors.forename: T
authors.initials: T
authors.lastname: Wentzel-Larsen
authors.forename: R
authors.initials: R
authors.lastname: Haaverstad
authors.forename: T
authors.initials: T
authors.lastname: Fanneløp
authors.forename: J E
authors.initials: JE
authors.lastname: Nordrehaug
mesh_terms: D000818:Animals; D002302:Cardiac Output; D016009:Chi-Square Distribution; D004867:Equipment Design; D006323:Heart Arrest / Q000503:physiopathology / Q000601:surgery*; D006336:Heart Massage / Q000379:methods*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D016018:Least-Squares Analysis; D008863:Microspheres; D011897:Random Allocation; D013552:Swine; D013908:Thoracotomy; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000503:physiopathology / Q000601:surgery*