Interleukin-10 gene polymorphisms in association with susceptibility to chronic hepatitis C virus infection: a meta-analysis study.
A relationship between chronic hepatitis C virus (HCV) infection and interleukin-10 (IL-10) gene polymorphisms has been reported with controversial results in different studies. In an effort to solve this controversy, we quantitatively summarized ten studies on this relationship by means of meta-analysis. Our analysis included ten case-control studies with 992 cases of chronic HCV infection and 1,123 controls. Analyses were performed with STATA version 9.0. The results showed that the IL-10 -1082GG genotype significantly increased the risk for persistent HCV infection (AA vs. GG: OR = 0.680, 95% CI = 0.489-0.947, P = 0.022; AG vs. GG: OR = 0.608, 95% CI = 0.439-0.840, P = 0.003; GG vs. AG + AA: OR = 1.570, 95% CI = 1.160-2.123, P = 0.003), but no statistically significant differences were observed between cases and controls for IL-10 -819C/T and IL-10 -592C/A polymorphisms (P > 0.05). In conclusion, this meta-analysis suggested that the IL-10 -1082GG genotype was associated with increased susceptibility for chronic HCV infection.
Zhang
Li-Zhou
LZ
Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Zhang
Tian-Chen
TC
Pan
Fa-Ming
FM
Zhang
Zhen-Hua
ZH
Li
Xu
X
D020022:Genetic Predisposition to Disease; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D016753:Interleukin-10