Circadian clocks and metabolism: the nutrient-sensing AKT and TOR pathways make the link.
How do organisms sense metabolic and nutrient status to set their biological clocks? The significance of recent work showing that nutrient-sensing pathways influence central circadian clocks in Drosophila is discussed.
Giebultowicz
Jadwiga
J
Oregon State University, Department of Zoology, 3029 Cordley Hall, Corvallis, OR 97331, USA. giebultj@science.oregonstate.edu
Kapahi
Pankaj
P
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D029721:Drosophila Proteins; D020794:Receptor Protein-Tyrosine Kinases; C080148:tor protein, Drosophila; D051057:Proto-Oncogene Proteins c-akt