title: Relationship between knee and ankle degeneration in a population of organ donors.
abstract: BACKGROUND
  Osteoarthritis (OA) is a progressive degenerative condition of synovial joints in response to both internal and external factors. The relationship of OA in one joint of an extremity to another joint within the same extremity, or between extremities, has been a topic of interest in reference to the etiology and/or progression of the disease.
  
  
  METHODS
  The prevalence of articular cartilage lesions and osteophytes, characteristic of OA, was evaluated through visual inspection and grading in 1060 adult knee/tali pairs from 545 cadaveric joint donors.
  
  
  RESULTS
  Joint degeneration increased more rapidly with age for the knee joint, and significantly more knee joints displayed more severe degeneration than ankle joints from as early as the third decade. Women displayed more severe knee degeneration than did men. Severe ankle degeneration did not exist in the absence of severe knee degeneration. The effect of weight on joint degeneration was joint-specific whereby weight had a significantly greater effect on the knee. Ankle grades increasingly did not match within a donor as the grade of degeneration in either the left or the right knee increased.
  
  
  CONCLUSIONS
  Gender and body type have a greater effect on knee joint integrity as compared to the ankle, suggesting that knees are more prone to internal causative effects of degeneration. We hypothesize that the greater variability in joint health between joints within an individual as disease progresses from normal to early signs of degeneration may be a result of mismatched limb kinetics, which in turn might lead to joint disease progression.
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Cohn Research Building, 1735 W. Harrison, Chicago, IL 60612, USA. carol_muehleman@rush.edu
authors.forename: Carol
authors.initials: C
authors.lastname: Muehleman
authors.forename: Arkady
authors.initials: A
authors.lastname: Margulis
authors.forename: Won C
authors.initials: WC
authors.lastname: Bae
authors.forename: Koichi
authors.initials: K
authors.lastname: Masuda
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000473:pathology*; D001835:Body Weight; D005260:Female; D006801:Humans; D007717:Knee / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology* / Q000473:pathology*; D015995:Prevalence; D012737:Sex Factors; D014019:Tissue Donors