title: Wound healing evaluation of sodium fucidate-loaded polyvinylalcohol/sodium carboxymethylcellulose-based wound dressing.
abstract: The cross-linked hydrogel films containing sodium fucidate were previously reported to be prepared polyvinyl alcohol (PVA) and sodium carboxymethylcellulose (Na-CMC) using the freeze-thawing method and their physicochemical property was investigated. For the development of novel sodium fucidate-loaded wound dressing, here its in vivo wound healing test and histopathology were performed compared with the conventional ointment product. In wound healing test, the sodium fucidate-loaded composed of 2.5% PVA, 1.125% Na-CMC and 0.2% drug showed faster healing of the wound made in rat dorsum than the hydrogel without drug, indicating the potential healing effect of sodium fucidate. Furthermore, from the histological examination, the healing effect of sodium fucidate-loaded hydrogel was greater than that of the conventional ointment product and hydrogel without drug, since it might gave an adequate level of moisture and build up the exudates on the wound area. Thus, the sodium fucidate-loaded wound dressing composed of 5% PVA, 1.125% Na-CMC and 0.2% drug is a potential wound dressing with excellent wound healing.
authors.affiliation: Yeungnam University, Gyongsan, Korea.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Soo-Jeong
authors.initials: SJ
authors.lastname: Lim
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Oh
authors.forename: Sae Kwang
authors.initials: SK
authors.lastname: Ku
authors.forename: Dong Xun
authors.initials: DX
authors.lastname: Li
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
mesh_terms: D000818:Animals; D001684:Biological Dressings / Q000592:standards*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage* / Q000592:standards; D003432:Cross-Linking Reagents / Q000008:administration & dosage / Q000592:standards; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005672:Fusidic Acid / Q000008:administration & dosage* / Q000592:standards; D008297:Male; D011142:Polyvinyl Alcohol / Q000008:administration & dosage* / Q000592:standards; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D003432:Cross-Linking Reagents; D005672:Fusidic Acid; D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium