title: Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
abstract: A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
authors.affiliation: University Health Network, Toronto, Ontario, Canada.
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authors.lastname: Liu
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authors.lastname: Invernizzi
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authors.lastname: Ransom
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authors.lastname: Benedetti
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authors.lastname: Fabris
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authors.lastname: Portincasa
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authors.lastname: Casella
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authors.lastname: Morini
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authors.lastname: Colli
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authors.lastname: Gregersen
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authors.forename: Gideon M
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authors.lastname: Hirschfield
authors.forename: Katherine A
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authors.lastname: Siminovitch
authors.forename: Christopher I
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authors.lastname: Gershwin
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authors.lastname: Seldin
mesh_terms: D000483:Alleles; D002170:Canada; D016678:Genome; D055106:Genome-Wide Association Study; D006801:Humans; D050835:Interferon Regulatory Factors; D008105:Liver Cirrhosis, Biliary; D015201:Meta-Analysis as Topic; D016017:Odds Ratio; D044465:White People / Q000235:genetics*
chemical_list: C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors