Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated beta-amino ester stereoisomers.
Enantiomerically enriched hydroxy-substituted beta-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee > or = 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 degrees C with 0.5 equiv. of added H(2)O as nucleophile.
Forró
Eniko
E
Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.
Schönstein
László
L
Kiss
Loránd
L
Vega-Peñaloza
Alberto
A
Juaristi
Eusebio
E
Fülöp
Ferenc
F
D000598:Amino Acids, Cyclic / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
D000598:Amino Acids, Cyclic; D004952:Esters