Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.
We report the ex vivo lysogenic transfer of erythromycin and tetracycline resistance genes among group A streptococci (GAS). Of 42 susceptible strains, 69% acquired erythromycin/tetracycline resistance when infected with purified supernatants from strain m46 culture containing the phage Φm46.1. A significant emm-type-dependent barrier to lysogenic transfer was not observed. The emm12 strains were the only strains susceptible to the lytic action of the bacteriophage preparation.
Di Luca
Maria Chiara
MC
School of Pharmacy, Microbiology Unit, University of Camerino, I-62032 Camerino, MC, Italy.
D'Ercole
Stefania
S
Petrelli
Dezemona
D
Prenna
Manuela
M
Ripa
Sandro
S
Vitali
Luca A
LA
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology*; D008242:Lysogeny / Q000235:genetics*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000235:genetics*; D013753:Tetracycline Resistance / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004917:Erythromycin