title: International human xenotransplantation inventory.
abstract: BACKGROUND
  Xenotransplantation carries inherent risks of infectious disease transmission to the recipient and even to society at large, and it should only be carried out with strict regulation and oversight. In collaboration with the International Xenotransplantation Association, the University Hospital Geneva, and the World Health Organization, an international inventory has been established (www.humanxenotransplant.org) aiming to collect basic data on all types of currently ongoing or recently performed xenotransplantation procedures in humans.
  
  
  METHODS
  We collected information from publications in scientific journals, presentations at international congresses, the internet, and declarations of International Xenotransplantation Association members on xenotransplantation procedures in humans performed during the past 15 years.
  
  
  RESULTS
  We identified a total of 29 human applications of xenotransplantation, including 7 that were currently ongoing. Procedures involved transplantation of xenogeneic cells, i.e., islets of Langerhans, kidney cells, chromaffin cells, embryonic stem cells, fetal and adult cells from various organs or extracorporeal perfusion using hepatocytes, liver, spleen, or kidney. The treatments were performed in 12 different countries, 9 of them having no national regulation on xenotransplantation.
  
  
  CONCLUSIONS
  Several clinical applications of cell xenotransplantation are ongoing around the world, often without any clear governmental regulation. This information should be used to inform national health authorities, healthcare staff, and the public, with the objective of encouraging good practices, with internationally harmonized guidelines and regulation of xenotransplantation.
authors.affiliation: Surgical Research Unit, Department of Surgery, Geneva University Hospital, Switzerland.
authors.forename: Antonino
authors.initials: A
authors.lastname: Sgroi
authors.forename: Leo H
authors.initials: LH
authors.lastname: Bühler
authors.forename: Philippe
authors.initials: P
authors.lastname: Morel
authors.forename: Megan
authors.initials: M
authors.lastname: Sykes
authors.forename: Luc
authors.initials: L
authors.lastname: Noel
mesh_terms: D000328:Adult; D000818:Animals; D006224:Cricetinae; D006801:Humans; D007239:Infections / Q000453:epidemiology / Q000209:etiology / Q000635:transmission; D016381:Islets of Langerhans Transplantation / Q000706:statistics & numerical data; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D011817:Rabbits; D012756:Sheep; D013552:Swine; D014180:Transplantation / Q000706:statistics & numerical data; D014183:Transplantation, Heterologous / Q000009:adverse effects / Q000331:legislation & jurisprudence / Q000706:statistics & numerical data*; D014944:World Health Organization