title: Gustation genetics: sweet gustducin!
abstract: Two recent studies, the second of which is reported herein, provide evidence that genetic variation in the sweet receptor subunit, TAS1R3, and the second messenger, gustducin (GNAT3), affect the ability of people to correctly sort ascending concentrations of sucrose. These findings raise questions about how variation in the TAS1R3 and GNAT3 gene shape the human sweet tooth and its unwelcome consequences, diabetes and obesity.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, PA 19104, USA. reed@monell.org
authors.forename: Danielle R
authors.initials: DR
authors.lastname: Reed
authors.forename: Robert F
authors.initials: RF
authors.lastname: Margolskee
mesh_terms: D014644:Genetic Variation; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D013395:Sucrose / Q000737:chemistry* / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*; D013650:Taste Buds / Q000378:metabolism; D015293:Transducin / Q000235:genetics*
chemical_list: D043562:Receptors, G-Protein-Coupled; C431926:taste receptors, type 1; C075192:gustducin; D013395:Sucrose; D015293:Transducin