title: The HTR1A and HTR1B receptor genes influence stress-related information processing.
abstract: The serotonergic system has been widely implicated in stress related psychiatric disorders such as depression and anxiety. We investigated the possible association between depression and anxiety scores and SNPs within the HTR1A and HTR1B genes in a population sample (n=1387). There was no direct SNP-phenotype association, but in interaction with recent stressful life events rs6295 G, rs878567 T alleles and rs6296 C alleles were associated with significantly higher symptom scores. A subset of control subjects (n=101) took part in a computerised face emotion processing task. Healthy rs6295 GG carriers did not show an affective bias to perceive more negative emotions but reacted more quickly to fearful faces. Thus we conclude that the serotonin-1A receptor conveys vulnerability to these psychiatric disorders by modulating threat-related information processing. Our results extend previous findings of an interaction between stressful life events and the serotonin transporter gene to two other genes in the serotonergic pathway and emphasise the possible role of increased threat-related information processing as an intermediate phenotype.
authors.affiliation: Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, UK.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Mekli
authors.forename: Antony
authors.initials: A
authors.lastname: Payton
authors.forename: Fabio
authors.initials: F
authors.lastname: Miyajima
authors.forename: Hazel
authors.initials: H
authors.lastname: Platt
authors.forename: Emma
authors.initials: E
authors.lastname: Thomas
authors.forename: Darragh
authors.initials: D
authors.lastname: Downey
authors.forename: Kathryn
authors.initials: K
authors.lastname: Lloyd-Williams
authors.forename: Diana
authors.initials: D
authors.lastname: Chase
authors.forename: Zoltan G
authors.initials: ZG
authors.lastname: Toth
authors.forename: Rebecca
authors.initials: R
authors.lastname: Elliott
authors.forename: William E
authors.initials: WE
authors.lastname: Ollier
authors.forename: Ian M
authors.initials: IM
authors.lastname: Anderson
authors.forename: J F William
authors.initials: JF
authors.lastname: Deakin
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Bagdy
authors.forename: Gabriella
authors.initials: G
authors.lastname: Juhasz
mesh_terms: D000328:Adult; D000483:Alleles; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D003071:Cognition; D015331:Cohort Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D003863:Depression / Q000235:genetics* / Q000523:psychology; D004644:Emotions; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013315:Stress, Psychological / Q000235:genetics* / Q000523:psychology; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; D004247:DNA