Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201.
This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.
Heo
Jin-Chul
JC
Food & Bio-Industry Research Institute, Kyungpook National University, Daegu, Korea.
Nam
Sung-Hee
SH
Nam
Dong-Yoon
DY
Kim
Jong-Guk
JG
Lee
Kwang-Gil
KG
Yeo
Joo-Hong
JH
Yoon
Cheol-Sik
CS
Park
Chul-Hong
CH
Lee
Sang-Han
SH
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000276:immunology; D016535:Bronchial Hyperreactivity / Q000276:immunology; D002460:Cell Line / Q000187:drug effects; D032661:Cordyceps / Q000737:chemistry* / Q000166:cytology; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D008168:Lung / Q000166:cytology / Q000187:drug effects; D008297:Male; D008518:Medicine, East Asian Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D025282:Mycelium / Q000737:chemistry* / Q000648:ultrastructure; D010047:Ovalbumin / Q000276:immunology; D013154:Spleen / Q000166:cytology
D018927:Anti-Asthmatic Agents; D016207:Cytokines; D010047:Ovalbumin