title: Infected Rathke cleft cysts: distinguishing factors and factors predicting recurrence.
abstract: BACKGROUND
  Rathke cleft cysts (RCCs) are benign sellar lesions that are generally asymptomatic but sometimes warrant transsphenoidal drainage. Small case reports have described infected RCCs, but this phenomenon remains uncharacterized.
  
  
  OBJECTIVE
  We reviewed RCCs over 23 years at our institution to determine factors predicting infection and recurrence.
  
  
  METHODS
  We retrospectively reviewed the magnetic resonance images, laboratory results, microbiology, and pathology of 176 RCC patients (1985-2008) who underwent initial operation at our institution (n = 170) or at another institution followed by recurrence managed at our institution (n = 6).
  
  
  RESULTS
  There were 3 RCC categories: cysts cultured intraoperatively during initial surgery (n = 21), cysts not cultured during initial surgery but cultured during subsequent surgery (n = 9), and cysts that were never cultured (n = 146). Cultured cysts were larger (1.6 vs 1.2 cm; P = .002) and had more frequent pituitary dysfunction (76% vs 30%; P < .001) than noncultured cysts. Restricted diffusion was also more common in cultured cysts (50% vs 0%; P = .02). Of cysts cultured at initial or subsequent surgery, 48% and 44%, respectively, had positive cultures (n = 14) and were treated with antibiotics. The most common organisms were Staphylococcus epidermidis (64%) and Propionibacterium acnes (57%). Kaplan-Meier recurrence rates were 13% (culture positive/antibiotic treated), 31% (culture negative/not antibiotic treated), and 9% (noncultured) (P = .002, cultured vs noncultured; P = .002, culture negative/not antibiotic treated vs non-cultured; P = .5 culture positive/antibiotic treated vs noncultured).
  
  
  CONCLUSIONS
  Suspected RCC infection, regardless of culture results, is a strong predictor of recurrence and may warrant antibiotic treatment. With antibiotic treatment, the recurrence rate of infected RCC approaches that of noninfected cysts. The higher recurrence rates reported in other series may reflect underrecognition of occult infection.
authors.affiliation: Department of Neurosurgery, University of California at San Francisco, San Francisco, California, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Tate
authors.forename: Arman
authors.initials: A
authors.lastname: Jahangiri
authors.forename: Lewis
authors.initials: L
authors.lastname: Blevins
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kunwar
authors.forename: Manish K
authors.initials: MK
authors.lastname: Aghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020806:Central Nervous System Bacterial Infections / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology*; D020863:Central Nervous System Cysts / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D004660:Encephalitis / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult