title: Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model.
abstract: Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.
authors.affiliation: Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. richard.a.peterson@gsk.com
authors.forename: Richard A
authors.initials: RA
authors.lastname: Peterson
authors.forename: David L
authors.initials: DL
authors.lastname: Krull
authors.forename: H Roger
authors.initials: HR
authors.lastname: Brown
authors.forename: Mark
authors.initials: M
authors.lastname: de Serres
mesh_terms: D000818:Animals; D001648:Bile Canaliculi / Q000473:pathology; D049109:Cell Proliferation; D002675:Child, Preschool; D005234:Fatty Liver / Q000473:pathology; D022781:Hepatocytes / Q000473:pathology / Q000637:transplantation*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D055806:Microvessels / Q000473:pathology; D018183:Transplantation Chimera; D014183:Transplantation, Heterologous; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics / Q000378:metabolism*
chemical_list: D014568:Urokinase-Type Plasminogen Activator