Comparative study of doses of exogenous progesterone administration needed to delay parturition in Jcl:MCH(ICR) mice.
The effects of progesterone (P4) used in physiological studies and in delayed parturition in reproductive engineering were examined. A dose of 0.25, 0.5, 1, or 2 mg of P4 was repeatedly administered to Jcl:MCH(ICR) mice on days 17 and 18 of gestation, and plasma concentrations of P4 were investigated. The P4 concentrations in mothers and fetuses after administration of exogenous P4 were no differences between doses of 1 and 2 mg. Jcl:MCH(ICR) mothers administered a P4 dose of 1 mg did not give birth. Therefore, we consider 2 mg of P4 is an overdose and that it is evident that a dose of 1 mg P4 is sufficient to induce delayed parturition.
Hashimoto
Haruo
H
Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan.
Eto
Tomoo
T
Endo
Keiko
K
Itai
Gen
G
Kamisako
Tsutomu
T
Suemizu
Hiroshi
H
Ito
Mamoru
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D007743:Labor, Obstetric / Q000097:blood / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D036801:Parturition / Q000097:blood / Q000187:drug effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000139:chemically induced; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D011372:Progestins / Q000097:blood / Q000494:pharmacology*
D011372:Progestins; D011374:Progesterone