title: Acquired von Willebrand disease secondary to hypothyroidism: a rare cause for postextraction hemorrhage.
abstract: Acquired von Willebrand's Disease (AvWD) is a rare disease with a clinical pattern similar to the congenital disorder that typically presents later in life in patients with no prior history of prolonged bleeding. It has been shown to be related to a number of common medical conditions including lymphoproliferative and myeloproliferative diseases, cardiovascular disease, immunological disorders, neoplasia, drugs, and miscellaneous disorders. We present 2 cases where post- and interoperative hemorrhage were the initial sign of AvWD and a previously undiagnosed hypothyroid condition was the precipitating factor. There are no similar cases reported within the dental literature. We highlight the importance of taking a medical history and bleeding history in all patients about to undergo oral surgery, periodontal surgery, or implant placement. Increased vigilance is suggested when patients, who have been otherwise well, present with abnormal bleeding problems as this may be a manifestation of an underlying undiagnosed disease.
authors.affiliation: Department of Oral Surgery, School of Dentistry, Royal Victoria Hospital, Belfast, Northern Ireland. Johnhanratty@gmail.com
authors.forename: John M
authors.initials: JM
authors.lastname: Hanratty
authors.forename: C G
authors.initials: CG
authors.lastname: Cowan
mesh_terms: D000328:Adult; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis; D007431:Intraoperative Complications / Q000209:etiology; D008297:Male; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000209:etiology*; D019106:Postoperative Hemorrhage / Q000209:etiology*; D014081:Tooth Extraction / Q000009:adverse effects*; D014842:von Willebrand Diseases / Q000150:complications* / Q000175:diagnosis