Apolipoprotein-E genotypes and myasthenia gravis.
Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in the development of the MG has been documented. This case-control study, studied the association of apolipoprotein E (Apo-E) alleles with MG. Anti-AChR antibody was measured using radio receptor immunoassay. Apo-E genotypes were analyzed in 120 MG patients and 120 healthy subjects. Comparison between patients with MG and controls showed no significant association with Apo-E allelic variants. However, a significant association of Apo-E4 allele with AChR-antibody positive patients was observed (P = 0.007). Also, among seropositive patients, a significant association was seen between female gender and Apo-E4 allele (P = 0.023). Our results suggest that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.
Suhail
Hamid
H
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Soundararajan
Christhunesa C
CC
Vivekanandhan
Subbiah
S
Singh
Sumit
S
Behari
Madhuri
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D015984:Causality; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D011950:Receptors, Cholinergic / Q000276:immunology; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult
D000906:Antibodies; D001057:Apolipoproteins E; D011950:Receptors, Cholinergic