title: Surgical intervention for patent ductus venosus.
abstract: Patent ductus venosus (PDV) is a rare condition, which usually presents secondary to hepatic atrophy and hepatic failure. We have treated eight cases of PDV, all with hypergalactosemia and hyperbilirubinemia. Ultrasonography and three-dimensional computed tomography demonstrated communication between the portal vein and the inferior vena cava. Of the eight PDV cases, three from the older age group (ages 9, 11, and 14 years) had high-density lesions in their brain nucleus, and one case (age 19 years) had undergone prior Kasai portoenterostomy for biliary atresia. Six PDV patients underwent ligation of PDV and the remaining two cases underwent partial banding of PDV with intraoperative monitoring to maintain portal vein pressure (PVP) under 30 cm H(2)O. Improvement of the intrahepatic portal vein flow was achieved by ligation or banding of PDV. Postoperatively, serum galactose and bilirubin fell to normal ranges, but portal thrombus occurred postoperatively in the first case. We subsequently administered postoperative anticoagulation in the remaining cases and experienced no major complications. These results suggest that PDV ligation and banding are effective surgical approaches for patients with PDV. Close postoperative monitoring to avoid portal thrombus is imperative in these cases.
authors.affiliation: Department of Pediatric Surgery, Graduate School of Biomedical Science, Natural Center for Basic Research and Development, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
authors.forename: Arata
authors.initials: A
authors.lastname: Kamimatsuse
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Onitake
authors.forename: Naomi
authors.initials: N
authors.lastname: Kamei
authors.forename: Go
authors.initials: G
authors.lastname: Tajima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sakura
authors.forename: Taijiro
authors.initials: T
authors.lastname: Sueda
authors.forename: Eiso
authors.initials: E
authors.lastname: Hiyama
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010690:Phlebography; D011169:Portal Vein / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000601:surgery*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D054079:Vascular Malformations / Q000175:diagnosis / Q000601:surgery*; D014656:Vascular Surgical Procedures / Q000379:methods*; D014682:Vena Cava, Inferior / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000601:surgery*; D055815:Young Adult