title: Number of hysteroscopies and the time interval between hysteroscopy and surgery: influence on peritoneal cytology in patients with endometrial cancer.
abstract: OBJECTIVE
  Hysteroscopy is a routine procedure for the diagnosis of endometrial cancer (EC). Moreover, with implementation of sentinel lymph node technique, a second hysteroscopy is necessary for technetium injection before performing lymphadenectomy. As yet, no data are available showing whether the time interval between hysteroscopy and definitive surgery, or the number of preoperative hysteroscopies, have an influence on the intraperitoneal cytology results.
  
  
  METHODS
  Data from patients with EC undergoing surgery in the years 2005-2008 at the Department of Obstetrics and Gynecology, University of Tübingen, were analyzed retrospectively. Cytological results were correlated with the number of preoperative hysteroscopies and with the time interval between hysteroscopy and surgery.
  
  
  RESULTS
  In 2005-2008, a total of 196 patients with EC and known cytological results underwent surgery. Positive cytological results (C+) were obtained in 11 patients (5.6%). The rate of C+ in patients without hysteroscopy was 18.2% (n=4) and in patients after one and two hysteroscopies, 1.9% (n=2) and 7.1% (n=5), respectively (p=0.008). The rate of C+ in patients with early EC (FIGO I and II) increased after two hysteroscopies (3.1% vs. 1% after one hysteroscopy and 0% without hysteroscopy) but the difference did not reach statistical significance (p=0.513). The mean time interval between hysteroscopy and definitive surgery with cytological examination was 11.1+/-15.2 days (range 0-97 days, median=1). C+ in the group of patients with a time gap between hysteroscopy and surgery of <or=1 days was found in 6 cases (8.1%), while in the group with a time gap >1 day there was in 1 case (p=0.161).
  
  
  CONCLUSIONS
  The finding of positive cytology results is independent from the time interval between preoperative hysteroscopy and definitive surgery. Furthermore, multiple hysteroscopies do not appear to significantly increase peritoneal tumor cell dissemination. Hysteroscopy is safe and indispensable in patients with EC.
authors.affiliation: Department of Obstetrics and Gynecology, University of Saarland, Kirrbergerstr. 100, 66424 Homburg/Saar, Germany. ingolf.juhasz-boess@uks.eu
authors.forename: Ingolf
authors.initials: I
authors.lastname: Juhasz-Böss
authors.forename: Tanja
authors.initials: T
authors.lastname: Fehm
authors.forename: Alexander
authors.initials: A
authors.lastname: Nauth
authors.forename: Sven
authors.initials: S
authors.lastname: Becker
authors.forename: Ralf
authors.initials: R
authors.lastname: Rothmund
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gardanis
authors.forename: Bernhard
authors.initials: B
authors.lastname: Krämer
authors.forename: Diethelm
authors.initials: D
authors.lastname: Wallwiener
authors.forename: Erich
authors.initials: E
authors.lastname: Solomayer
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D010537:Peritoneum / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors