title: Single graft loss in dual renal transplant recipients: impact of graft placement on recipient outcomes.
abstract: We aimed to assess the impact of graft placement in dual renal transplantation on the risk for single graft loss and to report recipient outcomes. Between 2004 and 2007, 55 dual renal transplants were performed at our institution. Allografts were placed bilaterally (one in each iliac fossa) in 42 patients and unilaterally (both in the same iliac fossa) in 14 patients. Nine recipients (16.4%) underwent explantation of a single graft as a consequence of vascular thrombosis designated as the SINGLE group, whereas 46 had two functional allografts (DUAL group). There was a higher rate of graft loss in case of unilateral placement (n = 5/14) compared with bilateral placement (n = 4/41) (35.7% vs. 9.8%, P = 0.035). One-year glomerular filtration rate was significantly lower in the SINGLE group (29.4 ml/min/1.73 m(2) vs. 49.4 ml/min/1.73 m(2) in the DUAL group, P < 0.05). Significantly, none of the nine recipients of the SINGLE group returned to dialysis with a mean follow-up of 34.1 months. Graft survival at 1 year was 100% and 97.9% in SINGLE and DUAL groups, respectively. Unilateral placement of both allografts is associated with an increased risk of single graft loss and therefore lower renal function at 1 year. However, this strategy is safe in selected indications.
authors.affiliation: Université Paris Descartes, Paris, France. marc-olivier.timsit@egp.aphp.fr
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Timsit
authors.forename: Marion
authors.initials: M
authors.lastname: Rabant
authors.forename: Renaud
authors.initials: R
authors.lastname: Snanoudj
authors.forename: Daniel
authors.initials: D
authors.lastname: Cohen
authors.forename: Ambroise
authors.initials: A
authors.lastname: Salin
authors.forename: Sayeed
authors.initials: S
authors.lastname: Malek
authors.forename: Yannick
authors.initials: Y
authors.lastname: Rouach
authors.forename: Henri
authors.initials: H
authors.lastname: Kreis
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.forename: Arnaud
authors.initials: A
authors.lastname: Mejean
mesh_terms: D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods*; D008297:Male; D016896:Treatment Outcome