title: Chronic meningococcaemia and immunoglobulin A deficiency.
abstract: Chronic meningococcaemia is an unusual clinical presentation of Neisseria meningitidis infection. We describe the case of a patient, who presented with total IgA deficiency and partial IgM deficiency with a low switched memory B cells count, suggestive of a borderline form of common variable immunodeficiency (CVID). The role of IgA in the protection against Neisseria meningitidis, and the link between IgA deficiency and CVID are discussed.
authors.affiliation: Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Theulin
authors.affiliation: Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
authors.forename: Murielle
authors.initials: M
authors.lastname: Rondeau-Lutz
authors.affiliation: Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Kuhnert
authors.affiliation: Clinical Immunology Department, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Boileau
authors.affiliation: Department of Internal Medicine, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l'Hôpital, 67091 Strasbourg Cedex, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Weber
mesh_terms: D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis*; D005076:Exanthema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008589:Meningococcal Infections / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology; D009345:Neisseria meningitidis / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D007070:Immunoglobulin A