An indication for correlation between the serum ADA level and gastric cancer risk.
BACKGROUND
Gastric atrophy caused by Helicobacter pylori (H. pylori) infection is a risk factor for gastric cancer. We aimed to evaluate the relationship between gastric cancer risk and tumor markers in the general population.


METHODS
A total of 688 volunteers were examined to test their serum pepsinogen (PG) levels and anti-H. pylori antibodies, in addition to a total of 22 serum tumor markers. The participants were classified into four groups according to their anti-H. pylori antibody and serum PG serological status. Accordingly, groups A and D were negative, whereas groups B and C were positive for anti-H. pylori antibodies; and groups A and B were normal, whereas groups C and D were abnormal for serum PG levels. All the blood examination results were statistically evaluated using Student's t-test among these groups.


RESULTS
There were 424, 202, 50, and 12 individuals in groups A, B, C, and D, respectively. Because of the small number of participants in groups C and D, we combined these two groups. Compared to the normal group (A), a statistically significant higher in adenosine deaminase level was found in group C+D (p=0.01).


CONCLUSIONS
This result supports a previous study indicating that adenosine deaminase is involved in the regulatory system of chronic atrophic gastritis and gastric cancer risk.
Ri
Gyokuto
G
International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, Tokyo, Japan.
Ohno
Satoshi
S
Furutani
Michiko
M
Furutani
Yoshiyuki
Y
Tsukahara
Tetsuo
T
Hagita
Norihiro
N
Haruyama
Hiromi
H
Nakamura
Shinichi
S
Yamamoto
Toshiyuki
T
Matsuoka
Rumiko
R
D000243:Adenosine Deaminase / Q000097:blood* / Q000502:physiology; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005757:Gastritis, Atrophic / Q000201:enzymology / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000209:etiology
D020116:Pepsinogen A; D000243:Adenosine Deaminase