Comparative effects of various commercially available mouthrinse formulations on oral malodor.
OBJECTIVE
The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodor reduction against four commercially available mouthwashes and negative control. A secondary aim was to compare the two methods for measuring volatile sulphur compounds (VSC) by halimetry and OralChroma.


METHODS
Organoleptic scale, halimeter and the OralChroma were used to assess oral malodour and VSC. The effects of five test formulations and water (negative control) were assessed after 30, 60, 90 and 180 min, with 1 week between the treatments to avoid any cross-over effect.


RESULTS
Reduction in H(2) S by halimetry and malodour levels by organoleptic assessment ranged from, slight (LacerFresh®) (P > 0.05), moderate (BreathRx®, SmartMouth® (P < 0.01) to marked effects (SB12®, Listerine®) (P < 0.001) at all time points compared with water. The largest differences were observed at 30 min and decreased with time. SB12® showed separation from Listerine® at 180 min, using ANOVA plus Bonferroni's Multiple Comparison post-test (P < 0.05). Relationships between organoleptic, halimeter and OralChroma were between R² = 0.795 and 0.926.


CONCLUSIONS
SB12 shows a consistent and reproducible inhibitory effect on oral malodor parameters, which in turn correlate well with each other.
Saad
S
S
Microbiology Unit, University of West of England, Bristol, UK.
Greenman
J
J
Shaw
H
H
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D019817:Benzoic Acid / Q000627:therapeutic use; D001622:Betaine / Q000031:analogs & derivatives / Q000627:therapeutic use; D002594:Cetylpyridinium / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D002710:Chlorhexidine / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006209:Halitosis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use; D012903:Smell; D013457:Sulfur Compounds / Q000032:analysis; D013729:Terpenes / Q000627:therapeutic use; D013997:Time Factors; D014260:Triclosan / Q000627:therapeutic use; D055549:Volatile Organic Compounds / Q000032:analysis; D055815:Young Adult; D015032:Zinc / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D012459:Salicylates; D013457:Sulfur Compounds; D013729:Terpenes; D055549:Volatile Organic Compounds; D001622:Betaine; D014260:Triclosan; C057473:Listerine; C077055:cocamidopropyl betaine; D019817:Benzoic Acid; D002594:Cetylpyridinium; D015032:Zinc; D002710:Chlorhexidine