Isotretinoin effect on alveolar repair after exodontia--a study in rats.
OBJECTIVE
To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats.


METHODS
Wistar rats (60-day-old) were assigned to control (CG, n = 12) and experimental (EG, n = 20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy.


RESULTS
There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90.


CONCLUSIONS
Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.
Bergoli
Roberta Dalmolin
RD
Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas, Rua Gonçalves Chaves, 3.657/401 B, Pelotas, Rio Grande do Sul, Brazil. betabergoli@hotmail.com
Chagas Junior
Otacilio Luiz
OL
de Souza
Carlos Eduardo Chrzanowski Pereira
CE
Vogt
Beatriz Farias
BF
de Oliveira
Henrique Telles Ramos
HT
Etges
Adriana
A
Silva
Daniela Nascimento
DN
D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D003879:Dermatologic Agents / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D007180:Incisor / Q000601:surgery*; D015474:Isotretinoin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
D003879:Dermatologic Agents; D015474:Isotretinoin; D002118:Calcium