title: Antimutagenic and antioxidant potentials of Teucrium ramosissimum essential oil.
abstract: The mutagenic and antimutagenic effects of the essential oil extracted from the aerial parts of Teucrium ramosissimum were evaluated by the bacterial reverse mutation assay in Salmonella typhimurium TA98, TA100, and TA1535, with and without exogenous metabolic activation (S9 fraction). The T. ramosissimum essential oil showed no mutagenic effect. In contrast, our results established that it possessed antimutagenic effects against sodium azide (SA), aflatoxin B1 (AFB1), benzo[a]pyrene (B[a]P), and 4-nitro-o-phenylenediamine (NOPD). The antioxidant capacity of the tested essential oil was evaluated using enzymatic, i.e., the xanthine/xanthine oxidase (X/XOD) assay, and nonenzymatic systems, i.e., the nitro-blue tetrazolium (NBT)/riboflavin and the DPPH assays. A moderate free radical-scavenging activity was observed towards DPPH(.) and O2(.-). In contrast, T. ramosissimum essential oil showed no effect for all the tested concentrations in the X/XOD assay.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Rue Avicenne, Monastir 5000, Tunisia.
authors.forename: Mohamed Ben
authors.initials: MB
authors.lastname: Sghaier
authors.forename: Jihed
authors.initials: J
authors.lastname: Boubaker
authors.forename: Aicha
authors.initials: A
authors.lastname: Neffati
authors.forename: Ilef
authors.initials: I
authors.lastname: Limem
authors.forename: Ines
authors.initials: I
authors.lastname: Skandrani
authors.forename: Wissem
authors.initials: W
authors.lastname: Bhouri
authors.forename: Ines
authors.initials: I
authors.lastname: Bouhlel
authors.forename: Soumaya
authors.initials: S
authors.lastname: Kilani
authors.forename: Leila
authors.initials: L
authors.lastname: Chekir-Ghedira
authors.forename: Kamel
authors.initials: K
authors.lastname: Ghedira
mesh_terms: D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D031367:Teucrium / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D016587:Antimutagenic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D009822:Oils, Volatile; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase