STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study.
Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR.
Fenstad
M H
MH
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway. mona.n.fenstad@ntnu.no
Johnson
M P
MP
Løset
M
M
Mundal
S B
SB
Roten
L T
LT
Eide
I P
IP
Bjørge
L
L
Sande
R K
RK
Johansson
A K
AK
Dyer
T D
TD
Forsmo
S
S
Blangero
J
J
Moses
E K
EK
Austgulen
R
R
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D015331:Cohort Studies; D003656:Decidua / Q000378:metabolism*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy
D002352:Carrier Proteins; C500784:STOX1 protein, human