Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma.
BACKGROUND
Curcumin is one of the most studied natural compounds which has been used as a feed additive for centuries. Curcumin exhibits low oral bioavailability in rodents and human. Curcumin formulated with phosphatidylcholine (Meriva) increases curcumin bioavailability five-fold compared to original curcumin. The aim of this study was to evaluate the efficacy of curcumin conjugated with phosphatidylcholine as an anticancer agent.


METHODS
In this xenograft study, mammary gland tumor cell line (ENU1564) was inoculated into the mammary fat pad of athymic nude mice. The mice were treated orally with either curcumin or Meriva. The tumor and its lung metastasis were evaluated grossly, microscopically, and immunohistochemically.


RESULTS
Meriva significantly reduced the expression of MMP-9 and lung metastasis of our cell line used in this experimental model.


CONCLUSIONS
Curcumin conjugated with phosphatidylcholine increased the efficacy of curcumin as an anticancer agent.
Ibrahim
Abdelazim
A
Department of Pathology, College of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
El-Meligy
Abdelmouneim
A
Fetaih
Hamdy
H
Dessouki
Amina
A
Stoica
George
G
Barhoumi
Rola
R
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D009336:Necrosis; D009368:Neoplasm Transplantation / Q000379:methods; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D010713:Phosphatidylcholines; D003474:Curcumin