The physiology and pathology of inositide signaling in the nucleus.
Nuclear inositide signaling is nowadays a well-established issue and a growing field of investigation, even though the very first evidence came out at the end of the 1980's. The understanding of its biological role is supported by the recent acquisitions dealing with pathology and namely hematological malignancies. Here, we review this issue highlighting the main achievements in the last years.
Ramazzotti
Giulia
G
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy.
Faenza
Irene
I
Fiume
Roberta
R
Matteucci
Alessandro
A
Piazzi
Manuela
M
Follo
Matilde Yung
MY
Cocco
Lucio
L
D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000502:physiology*; D005786:Gene Expression Regulation; D009190:Myelodysplastic Syndromes / Q000503:physiopathology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D010716:Phosphatidylinositols