Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.
N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.
Giraud
Francis
F
Université de Nantes, Nantes Atlantique Universités, Laboratoire de Chimie Thérapeutique, Cibles et Médicaments des Infections, de l'Immunité et du Cancer, IICiMed UPRES EA 1155, Faculté de Pharmacie, Nantes, France.
Marchand
Pascal
P
Carbonnelle
Delphine
D
Sartor
Michael
M
Lang
François
F
Duflos
Muriel
M
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D007211:Indoles / Q000737:chemistry; D020128:Inhibitory Concentration 50; D051379:Mice
D000577:Amides; D007166:Immunosuppressive Agents; D007211:Indoles