title: Improvement of hyperglycemia and sexual dysfunction in diabetic female rats by an artificial endocrine pancreas developed from mouse beta cells.
abstract: We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse beta cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse beta cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380-450 mg/dl induced by streptozotocin to 140-230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.
authors.affiliation: Central Institute for Experimental Animals, Kawasaki-shi, Kanagawa, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Moritani
authors.forename: Misao
authors.initials: M
authors.lastname: Terada
authors.forename: Pudcharaporn
authors.initials: P
authors.lastname: Kromkhun
authors.forename: Wirasak
authors.initials: W
authors.lastname: Fungfuaug
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakada
authors.forename: Makoto
authors.initials: M
authors.lastname: Yokosuka
authors.forename: Toru R
authors.initials: TR
authors.lastname: Saito
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006943:Hyperglycemia / Q000601:surgery*; D050417:Insulin-Secreting Cells; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D051379:Mice; D010052:Ovariectomy; D019397:Pancreas, Artificial; D011187:Posture; D051381:Rats; D012726:Sexual Behavior, Animal / Q000502:physiology; D012735:Sexual Dysfunction, Physiological / Q000503:physiopathology / Q000601:surgery*; D014183:Transplantation, Heterologous