Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement.
Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma characterized by specific morphological and immunophenotypic features. The basic genetic feature of BL is the rearrangement of MYC gene, visible as t(8;14)(q24;q32) translocation or its variant. However, some lymphomas with characteristic BL morphology are nowadays diagnosed as B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL (Inter-DLBCL/BL) for biological or clinical reasons. We present four lymphomas without the MYC rearrangement presented typical Burkitt morphology, FCM immunophenotype with some deviations when compared to a typical BL. The cases were finally diagnosed as Inter-DLBCL/BL. All of them presented a recurrent abnormality within the chromosome 11: dup(11)(q23q13). We suppose that the dup(11)(q23q13), in absence of the MYC gene rearrangement, is connected with borderline lymphomas with a morphology similar or identical to that of the Burkitt lymphoma. Identifying such an aberration may be helpful in the diagnostics of Inter-DLBCL/BL eventually forming a distinct subgroup of lymphomas.
Pienkowska-Grela
Barbara
B
Cytogenetic Laboratory, Department of Lymphoprolipherative Disease, MSCM Cancer Centre and Institute, 5 W.K. Roentgen Str., 02-781, Warsaw, Poland. barpien@coi.waw.pl
Rymkiewicz
Grzegorz
G
Grygalewicz
Beata
B
Woroniecka
Renata
R
Krawczyk
Paulina
P
Czyz-Domanska
Katarzyna
K
Walewski
Jan
J
D059786:Abnormal Karyotype; D000293:Adolescent; D000328:Adult; D002469:Cell Separation; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005434:Flow Cytometry; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology*; D008297:Male; D014314:Trisomy / Q000235:genetics*; D055815:Young Adult