Pandemic flu: a comparative evaluation of clinical, laboratory, and radiographic findings in HIV-positive and negative children.
Eleven HIV-infected and 30 otherwise healthy children hospitalized for H1N1 influenza were studied. Leukopenia was recorded in 64% of HIV-infected and in 20% of healthy children (P = 0.01). Chest radiograph was abnormal in 18 (46%) children. Interstitial pneumonia was more frequent in HIV-positive children and consolidation was more frequent in HIV-negative children. Although the duration of symptoms and hospital stay was significantly longer in HIV-negative than in HIV-positive children, only 37% of HIV-negative children and 91% of HIV-positive received oseltamivir. The H1N1 influenza attack rate was very high (20%) in HIV-infected children, but it consistently ran a mild course.
Giannattasio
Antonietta
A
Department of Pediatrics, University Federico II, Italy.
Lo Vecchio
Andrea
A
Russo
Maria Teresa
MT
Pirozzi
Maria Rosaria
MR
Barbarino
Alessandro
A
Ruberto
Eliana
E
Campa
Antonio
A
Guarino
Alfredo
A
D000293:Adolescent; D000998:Antiviral Agents; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006760:Hospitalization; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D007970:Leukopenia; D008297:Male; D058873:Pandemics; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
D000998:Antiviral Agents