title: Effect of pu-erh tea on body fat and lipid profiles in rats with diet-induced obesity.
abstract: The antiobesity and antihyperlipidaemic effects of pu-erh tea in rats with high fat diet (HFD)-induced obesity were investigated. Male Sprague-Dawley rats were randomly divided into five groups and fed varying diets for an 8-week period: control diet, HFD, and HFD supplemented with low, moderate or high doses of pu-erh tea extract (0.5 g, 2 g and 4 g/kg BW/day, respectively). Pu-erh tea significantly reduced the total body weight and the weight of various adipose pads. Pu-erh tea administration also significantly lowered plasma total cholesterol, triglyceride concentrations and low-density lipoprotein-cholesterol levels in rats with HFD-induced obesity, but did not affect high-density lipoprotein-cholesterol levels. Moreover, pu-erh tea significantly increased lipoprotein lipase, hepatic lipase and hormone-sensitive lipase activities in epididymal fat tissue in rats with HFD-induced obesity. Analysis of real-time reverse transcription-polymerase chain reaction results indicated that pu-erh tea significantly enhanced mRNA levels of hormone-sensitive lipase in rats with HFD-induced obesity. These results suggest that pu-erh tea attenuated visceral fat accumulation and improved hyperlipidemia in a rat model of HFD-induced obesity.
authors.affiliation: Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, People's Republic of China.
authors.forename: Zhen-Hui
authors.initials: ZH
authors.lastname: Cao
authors.forename: Da-Hai
authors.initials: DH
authors.lastname: Gu
authors.forename: Qiu-Ye
authors.initials: QY
authors.lastname: Lin
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Qi-Chao
authors.initials: QC
authors.lastname: Huang
authors.forename: Hua
authors.initials: H
authors.lastname: Rao
authors.forename: Er-Wei
authors.initials: EW
authors.lastname: Liu
authors.forename: Jun-Jing
authors.initials: JJ
authors.lastname: Jia
authors.forename: Chang-Rong
authors.initials: CR
authors.lastname: Ge
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004822:Epididymis / Q000187:drug effects; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050152:Intra-Abdominal Fat / Q000187:drug effects; D008049:Lipase / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D019440:Anti-Obesity Agents; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D013662:Tea; D014280:Triglycerides; D008049:Lipase