[The observation of the influence about blood pressure and cardiovascular B ultrasonic wave by chronic intermittent hypoxia].
OBJECTIVE
To investigate the influence of left heart function in obstructive sleep apnea by CIH, and explore left heart function and blood pressures before or after CPAP.


METHODS
75 OSA were divided into two groups: 40 patients blood pressures were coincident with diagnostic standard of hypertension recording; 35 patients blood pressures were non-hypertension recording. The control group included 30. healthy adults. The blood pressures before and also after sleep, left ventricular ejection fraction (LVEF), shortening fraction (FS), E, A and E/A were compared with those of normal control subjects. Analyzed BP, LVEF and E/A after CPAP.


RESULTS
(1) The blood pressure soon after getting up in the morning (150.80+/-20.73/108.0+/-15.34) mm Hg (1 mm Hg=0.133 kPa) was significantly higher than that before sleep (134.16+/-18.33/90.09+/-11.24) mm Hg (P<0.001). (2) Multiple parameters including LVEF, FS and E/A, were impaired in OSA patients relative to the control subjects (P<0.05 or P<0.01), OSA affected cardiovascular function directly; E/A was significantly decreased in obstructive sleep apnea unallied hypertension than that in normal control subjects; E/A was conspicuously decreased in obstructive sleep apnea associated hypertension comparing with that in obstructive sleep apnea unallied hypertension. These showed OSA affected cardiovascular function directly, hypertension aggravated the drop in cardiovascular function. 3. After CPAP in 6 months, it (142.59+/-15.34/96.52+/-9.81) mm Hg was significantly decreased than that before treatment (150.80+/-20.73/108.0+/-15.34) (P<0.001); LVEF (59.70+/-11.1)% was increased than that before treatment (56.40+/-9.74)% (P<0.05) and E/A 1.16+/-0.25 was increased. Than that before treatment 0.87+/-0.17 (P<0.01).


CONCLUSIONS
(1) CIH may affect left heart structure and function; these changes were aggravated with hypertension. (2) CPAP treatment had important sense in the treatment of hypertension and cardiovascular function, and improved the life quality.
Wang
Ying
Y
Department of Respiratory Medicine, First Hospital of in Jilin University, Changchun 130021, China.
Han
Li-li
LL
Xu
Jian-guo
JG
Wang
Chun-yong
CY
Yang
Song-qing
SQ
Liu
Pan
P
Li
Ming-xian
MX
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D018618:Echocardiography, Doppler, Color; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D000860:Hypoxia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left