Glyphosate-surfactant herbicide-induced reversible encephalopathy.
Glyphosate-surfactant (GlySH) is a commonly used herbicide that has been used in attempted suicide. Most reports of GlySH toxicity in patients have followed ingestion of the commercial product "Round-up" (Monsanto Ltd; Melbourne, Victoria, Australia), which consists of a mixture of glyphosate (as a isopropylanine salt) and a surfactant (polyoxyethyleneamine). Ingestion of Round-up is reported to cause significant toxicity including nausea, vomiting, oral and abdominal pain. Renal and hepatic impairment and pulmonary oedema may also occur. Impaired consciousness and encephalopathy have been reported as sequelae but there are limited data on the central nervous system (CNS) effects of Round-up toxicity. We report a 71-year-old male who attempted suicide with GlySH and developed a prolonged but reversible encephalopathy suggestive of acute CNS toxicity.
Malhotra
R C
RC
Department of Neurology, Liverpool Health Service, Level 1 CSB Locked Bag 7103, Liverpool BC, New South Wales 1871, Australia.
Ghia
D K
DK
Cordato
D J
DJ
Beran
R G
RG
D000138:Acidosis / Q000139:chemically induced / Q000175:diagnosis; D000208:Acute Disease; D000368:Aged; D003128:Coma / Q000139:chemically induced / Q000175:diagnosis; D015600:Glasgow Coma Scale; D005998:Glycine / Q000031:analogs & derivatives* / Q000506:poisoning; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D008297:Male; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000378:metabolism; D012770:Shock, Cardiogenic / Q000139:chemically induced / Q000175:diagnosis; D013501:Surface-Active Agents / Q000506:poisoning*; D000097797:Glyphosate
D005998:Glycine; D006540:Herbicides; D013501:Surface-Active Agents; D000097797:Glyphosate