title: Together we are strong--cell wall integrity sensors in yeasts.
abstract: The integrity of the fungal cell wall is ensured by a signal transduction pathway, the so-called CWI pathway, which has best been studied in the model yeast Saccharomyces cerevisiae. In this context, environmental stress and other perturbations at the cell surface are detected by a small set of plasma membrane-spanning sensors, viz. Wsc1, Wsc2, Wsc3, Mid2 and Mtl1. This review covers the recent advances in sensor structure, sensor mechanics, their cellular distribution and their in vivo functions, obtained from genetic, biochemical, cell biological and biophysical investigations.
authors.affiliation: Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, Spain.
authors.forename: Rosaura
authors.initials: R
authors.lastname: Rodicio
authors.forename: Jürgen J
authors.initials: JJ
authors.lastname: Heinisch
mesh_terms: D002473:Cell Wall / Q000378:metabolism / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C091625:MID2 protein, S cerevisiae; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C550933:Mtl1 protein, S cerevisiae; D011956:Receptors, Cell Surface; C119383:SLG1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C120218:WSC2 protein, S cerevisiae; C120219:WSC3 protein, S cerevisiae