title: Combined therapy for thyroid squamous cell carcinoma.
abstract: BACKGROUND.: Squamous carcinoma of the thyroid is a rare aggressive disease, resulting in poor prognosis. METHODS AND RESULTS.: We combined cisplatin with paclitaxel on a weekly basis as induction therapy, achieving a high cumulative dose, in a patient with squamous cell tumor of the thyroid with arterial encasement. After surgery, pathologic examination confirmed a complete resection of the primary tumor with clear margins, revealing a successful induction treatment with chemotherapy. CONCLUSIONS.: Our patient now has a recurrence-free survival of >20 months, longer than the mean survival described in the literature.
authors.affiliation: Department of Internal Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands. f.devos@erasmusmc.nl
authors.forename: Filip Yves F L
authors.initials: FY
authors.lastname: De Vos
authors.forename: Aniel
authors.initials: A
authors.lastname: Sewnaik
authors.forename: J Hans W
authors.initials: JH
authors.lastname: de Wilt
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Smid
authors.forename: Michael A
authors.initials: MA
authors.lastname: den Bakker
authors.forename: Esther
authors.initials: E
authors.lastname: van Meerten
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D017239:Paclitaxel; D002945:Cisplatin