Successful treatment of early detected trilateral retinoblastoma using standard infant brain tumor therapy.
Trilateral retinoblastoma is characterized by the presence of retinoblastoma with an intracranial tumor. The incidence is low and prognosis poor. Due to the paucity of information regarding successful treatment, we report the case of a 6 month old female referred for leukocoria and found to have an associated suprasellar tumor and pineal enhancement. The patient, treated with standard infant brain tumor therapy, remains alive without signs of active disease 35 months after diagnosis; no surgery or irradiation was used. Early diagnosis of trilateral retinoblastoma may facilitate the use of less intensive therapeutic approaches and result in excellent outcomes in these patients.
Wright
Karen D
KD
Department of Oncology, Division of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA. karen.wright@stjude.org
Qaddoumi
Ibrahim
I
Patay
Zoltan
Z
Gajjar
Amar
A
Wilson
Matthew W
MW
Rodriguez-Galindo
Carlos
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D010870:Pineal Gland; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D012175:Retinoblastoma / Q000175:diagnosis / Q000188:drug therapy*