Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy.
OBJECTIVE
To evaluate a possible correlation between transvaginal ultrasound findings in miscarriages and cytogenetic analyses from chorionic villi obtained by dilatation and curettage.


METHODS
Prospective, population-based study.


METHODS
University-based hospital.


METHODS
Five hundred seventy-six women with spontaneous miscarriage diagnosed between 6 and 12 completed pregnancy weeks.


METHODS
Transvaginal ultrasonography and dilatation and curettage.


METHODS
Cytogenetic analyses and ultrasound measurement of embryonic pole.


RESULTS
The mean gestational age was 9.5 weeks. Chromosomal analyses were successful in 259 cases, 159 with cytogenetic abnormalities and 100 euploidy. Empty gestational sacs were equally often found in euploidy and aneuploidy, whereas small embryonic or fetal poles were significantly more often associated with aneuploidy.


CONCLUSIONS
A smaller than expected fetal size when a miscarriage is diagnosed during the first trimester is significantly associated with a chromosomal aberration.
Ljunger
Elisabeth
E
Department of Women's and Children's Health, Uppsala University, and Uppsala Hospital, Uppsala, Sweden.
Stavreus-Evers
Anneli
A
Cnattingius
Sven
S
Ekbom
Anders
A
Lundin
Catarina
C
Annéren
Göran
G
Sundström-Poromaa
Inger
I
D000022:Abortion, Spontaneous / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D000328:Adult; D000782:Aneuploidy; D002824:Chorionic Villi / Q000473:pathology*; D002869:Chromosome Aberrations; D004107:Dilatation and Curettage; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal