Synthesis and antituberculosis activity of new fatty acid amides.
This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 microg/mL for resistance strains.
D'Oca
Caroline Da Ros Montes
Cda R
Laboratório Kolbe de Síntese Orgânica, Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
Coelho
Tatiane
T
Marinho
Tamara Germani
TG
Hack
Carolina Rosa Lopes
CR
Duarte
Rodrigo da Costa
Rda C
da Silva
Pedro Almeida
PA
D'Oca
Marcelo Gonçalves Montes
MG
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis*; D005227:Fatty Acids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013057:Spectrum Analysis / Q000379:methods
D000577:Amides; D000995:Antitubercular Agents; D005227:Fatty Acids