Measles outbreak in Tanzania, 2006-2007.
We conducted a measles outbreak investigation in Dar es Salaam, Tanzania. Surveillance data were analyzed; a susceptibility profile developed, and case-control study conducted. The age distribution of cases peaked among those <2, 5-7, and > or =18 years, corresponding to the age distribution of susceptibles. Risk factors included being unvaccinated (aOR=5.7, p<0.01) or having received one dose of vaccine compared to two (aOR=2.4, p=0.01), being younger, and having a less-educated caretaker. Vaccine effectiveness was 88% (one dose) and 96% (two doses). Results highlight the importance of receiving one dose of measles vaccine, and the added benefit of two doses.
Goodson
James L
JL
Centers for Disease Control and Prevention, Global Immunization Division, Atlanta, GA 30333, USA. JGoodson@cdc.gov
Perry
Robert T
RT
Mach
Ondrej
O
Manyanga
David
D
Luman
Elizabeth T
ET
Kitambi
Mary
M
Kibona
Mary
M
Wiesen
Eric
E
Cairns
K Lisa
KL
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000453:epidemiology*; D008458:Measles Vaccine / Q000008:administration & dosage; D008962:Models, Theoretical; D012307:Risk Factors; D013636:Tanzania / Q000453:epidemiology; D055815:Young Adult
D008458:Measles Vaccine