Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory, anti-fungal and anti-leishmanial activities.
From the aerial parts of Buxus hyrcana, three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine (1), buxhyrcamine (2), and 31-demethylcyclobuxoviridine (3), along with 16 known compounds, cyclobuxoviridine (4), N(b)-dimethylcyclobuxoviricine (5), E-buxenone (6), Z-buxenone (7), moenjodaramine (8), homomoenjodarmine (9), buxamine A (10), buxamine B (11), 31-hydroxybuxamine B (12), N(20)-formylbuxaminol E (13), papillozine C (14), buxmicrophylline F (15), buxrugulosamine (16), cyclobuxophylline O (17), spirofornabuxine (18) and arbora-1,9(11)-dien-3-one (19) were isolated. Their structures were elucidated by using NMR spectroscopic methods. All of the compounds exhibited moderate to weak acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase inhibitory activities. Compounds 1-19 also exhibited modest anti-fungal activities against Candidaalbicans. Compounds 1, 2, 8, 9 and 18 also exhibited weak anti-leishmanial activity.
Ata
Athar
A
Department of Chemistry, The University of Winnipeg, Winnipeg, MB, Canada. a.ata@uwinnipeg.ca
Iverson
Chad D
CD
Kalhari
Kosmulalage S
KS
Akhter
Sarfraz
S
Betteridge
Jordan
J
Meshkatalsadat
Mohammad Hadi
MH
Orhan
Ilkay
I
Sener
Bilge
B
D000110:Acetylcholinesterase / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002091:Butyrylcholinesterase / Q000187:drug effects; D031235:Buxus / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005982:Glutathione Transferase; D007891:Leishmania / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000470:Alkaloids; D000981:Antiprotozoal Agents; D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D014315:Triterpenes; D005982:Glutathione Transferase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase