title: Analgesic activity of Heliopsis longipes and its effect on the nervous system.
abstract: Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system (NS) have not been investigated yet. The objectives of this study were to evaluate the analgesic action of affinin and the H. longipes root ethanol extract, as well as their effects on the NS using an animal model. The ethanol extract was obtained by maceration, and affinin was purified from it through chromatographic techniques. Chemical and thermal analgesia were used to assess their analgesic proprieties. Irwin's test was used to evaluate their stimulating or depressing effects. The ethanol extract and affinin displayed analgesic action similar to ketorolac and stimulating effect comparable to caffeine on the nervous system of adult mice.
authors.affiliation: Programa Multidisciplinario de Posgrado en Ciencias Ambientales, UASLP San Luis Potosí, México.
authors.forename: V G
authors.initials: VG
authors.lastname: Cilia-López
authors.forename: B I
authors.initials: BI
authors.lastname: Juárez-Flores
authors.forename: J R
authors.initials: JR
authors.lastname: Aguirre-Rivera
authors.forename: J A
authors.initials: JA
authors.lastname: Reyes-Agüero
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D008519:Medicine, Traditional; D008800:Mexico; D051379:Mice; D009420:Nervous System / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D053284:Polyunsaturated Alkamides / Q000302:isolation & purification / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D018712:Analgesics, Non-Narcotic; D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; C489347:N-isobutyl-2E-decenamide; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides