Paradoxical development of a sarcoid-like reaction during successful chemotherapy for seminoma.
Although the association between seminoma and sarcoidosis or a sarcoid-like reaction has been well recognized, a paradoxical case during chemotherapy for seminoma has not been reported. We report the first case of a sarcoid-like reaction that developed paradoxically during successful chemotherapy for recurrent seminoma. A 36-year-old Japanese man had recurrent seminoma in abdominal lymph nodes four years after left orchiectomy. Chemotherapy consisting of bleomycin, etoposide and cisplatin had reduced the abdominal mass, but mediastinal and bilateral hilar lymphadenopathy newly appeared. Surgical biopsy of the mediastinal lymph nodes and left nephrectomy and retroperitoneal lymphadenectomy revealed noncaseating granulomas only in mediastinal lymph nodes and confirmed complete remission of seminoma. Nine months later the thoracic lymphadenopathy had resolved spontaneously.
Tanizawa
Kiminobu
K
Department of Respiratory Medicine, Tenri Hospital, Tenri, Japan. tanizawa@kuhp.kyoto-u.ac.jp
Tanaka
Eisaku
E
Hashimoto
Seishu
S
Noma
Satoshi
S
Kobashi
Yoichiro
Y
Okumura
Kazuhiro
K
Shindo
Toru
T
Taguchi
Yoshio
Y
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000139:chemically induced* / Q000175:diagnosis*; D018239:Seminoma / Q000188:drug therapy* / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D000970:Antineoplastic Agents