Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity.
Ruf
Wolfram
W
Versteeg
Henri H
HH
D000495:Allosteric Site / Q000235:genetics; D019943:Amino Acid Substitution; D003553:Cystine / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry; D042783:Endothelial Cells / Q000378:metabolism; D015942:Factor VIIa / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D016297:Mutagenesis, Site-Directed; D050505:Mutant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013925:Thromboplastin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D014161:Transduction, Genetic
D004220:Disulfides; D050505:Mutant Proteins; D011994:Recombinant Proteins; D003553:Cystine; D013925:Thromboplastin; D015942:Factor VIIa