Chitosan hydrogel with terbinafine--an evaluation of drug release.
The aim of this study was to evaluate rheological properties and release of terbinafine (an antifungal drug) from chitosan hydrogels, and test some additives as possible solvents, preservatives and potential chemical penetration enhancers. The release of terbinafine was better from hydrogel with glycerol (plastic flow), than that from hydrogel with propylene glycol (thixotropic flow), the presence of Tween 80 showed a negative influence on drug release from both types.
Matusová
D
D
Department of Pharmaceutical Technology, Slovak Medical University, Bratislava, Slovak Republic. desana.matusova@szu.sk
Vitková
Z
Z
Truplová
E
E
Herdová
P
P
D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D005079:Excipients; D020100:Hydrogels; D007700:Kinetics; D009281:Naphthalenes / Q000008:administration & dosage / Q000737:chemistry*; D011136:Polysorbates; D012212:Rheology; D012995:Solubility; D013501:Surface-Active Agents; D000077291:Terbinafine; D014783:Viscosity
D000935:Antifungal Agents; D005079:Excipients; D020100:Hydrogels; D009281:Naphthalenes; D011136:Polysorbates; D013501:Surface-Active Agents; D048271:Chitosan; D000077291:Terbinafine