Interaction of viruses with host cell molecular motors.
Viral particles are generally too large to diffuse freely within the crowded environment of the host cell cytoplasm. They depend on mammalian cell transport systems, in particular the microtubular molecular motor dynein, to deliver their nucleic acids to the vicinity of the nucleus. An understanding of how viruses interact with dynein, and its many accessory proteins, may reveal targets for drug discovery and will unlock the toolbox required to improve the performance of synthetic gene delivery systems.
Hsieh
Ming Je
MJ
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Melbourne, Australia.
White
Paul J
PJ
Pouton
Colin W
CW
D004398:Dyneins / Q000235:genetics / Q000378:metabolism; D018014:Gene Transfer Techniques; D008870:Microtubules / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D014780:Viruses / Q000235:genetics*
D020409:Molecular Motor Proteins; D004398:Dyneins