Artemisinins and the biological basis for the PfATP6/SERCA hypothesis.
With the advent of artemisinin resistance, it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs). Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.
Krishna
Sanjeev
S
Centre for Infection, Cellular and Molecular Medicine, St. George's University of London, Cranmer Terrace, London, UK, SW17 0RE. s.krishna@sgul.ac.uk
Pulcini
Serena
S
Fatih
Farrah
F
Staines
Henry
H
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000187:drug effects*; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors* / Q000187:drug effects*
D000962:Antimalarials; D037621:Artemisinins; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases