title: Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy.
abstract: Two oil-in-water formulations, containing equal amounts of apigenin-enriched chamomile flower extracts, for potential use as topical antiinflammatory agents, were prepared and their physicochemical properties evaluated. A pilot clinical study was then carried out to assess patient acceptability and efficacy. The creams were either non-liposomal or liposomal. The liposomal formulations were more viscous, thus producing superior release characteristics in vitro. The clinical study also showed that the liposomal creams were, as antiinflammatory agents, slightly more effective in vivo than the non-liposomal formulations. These results suggest that there is scope for the further development of even more effective and safer alternatives to corticosteroids.
authors.affiliation: Institute for Medicinal Plants Research 'Dr Josif Pančić', Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Arsić
authors.forename: Vanja
authors.initials: V
authors.lastname: Tadić
authors.forename: Djordje
authors.initials: D
authors.lastname: Vlaović
authors.forename: Irena
authors.initials: I
authors.lastname: Homšek
authors.forename: Sonja
authors.initials: S
authors.lastname: Vesić
authors.forename: Gorana
authors.initials: G
authors.lastname: Isailović
authors.forename: Gordana
authors.initials: G
authors.lastname: Vuleta
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D047310:Apigenin / Q000008:administration & dosage* / Q000494:pharmacology; D020843:Chamomile / Q000737:chemistry; D003877:Dermatitis, Contact / Q000188:drug therapy; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage* / Q000494:pharmacology; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D012867:Skin / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D008081:Liposomes; D009824:Ointments; D010936:Plant Extracts; D047310:Apigenin