Effect of anserine ingestion on hyperglycemia and the autonomic nerves in rats and humans.
Anserine and L-carnosine are similar dipeptides synthesized by muscles of vertebrates. The functional role of anserine is unknown, although previous studies showed hypoglycemic effects of carnosine through autonomic nerves. Thus, we evaluated the effects of anserine on blood glucose levels and the neural activities. Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for the blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine.
Kubomura
Daiki
D
R&D Functional Food Division, Yaizu Suisankagaku Industry Co. Ltd, Shizuoka, Japan. kubomura@yskf.co.jp
Matahira
Yoshiharu
Y
Nagai
Katsuya
K
Niijima
Akira
A
D000818:Animals; D000861:Anserine / Q000008:administration & dosage*; D017776:Autonomic Pathways / Q000187:drug effects* / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis / Q000502:physiology; D018592:Cross-Over Studies; D003847:Deoxyglucose / Q000008:administration & dosage; D004525:Efferent Pathways / Q000187:drug effects; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007700:Kinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000187:drug effects; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D005934:Glucagon; D003847:Deoxyglucose; D000861:Anserine