title: Helicobacter pylori induces expression and secretion of oncostatin M in macrophages in vitro.
abstract: BACKGROUND
  Helicobacter pylori is pathogenic bacterium that is associated with several gastric diseases in humans. Disease is characterized by severe inflammatory responses is the stomach that are induced by various chemokines and cytokines. Previous reports indicated that some of these responses are mediated through Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling.
  
  
  METHODS
  We performed JAK/STAT specific microarrays to identify new components of this signaling pathway, which are affected by Helicobacter pylori infection of THP-1 cells.
  
  
  RESULTS
  We found that expression and secretion of oncostatin M and of its receptor were strongly up-regulated by Helicobacter pylori. OSM secretion was independent of CagA, VacA or Type IV secretion system. Helicobacter pylori culture supernatant induced OSM secretion.
  
  
  CONCLUSIONS
  The induction of the pleiotropic cytokine oncostatin M suggests a possible role in Helicobacter pylori-mediated inflammation and diseases.
authors.affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, T6G 2H7, Canada.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Zeaiter
authors.forename: Hugo
authors.initials: H
authors.lastname: Diaz
authors.forename: Markus
authors.initials: M
authors.lastname: Stein
authors.forename: Hien Q
authors.initials: HQ
authors.lastname: Huynh
mesh_terms: D002460:Cell Line; D016480:Helicobacter pylori; D006801:Humans; D053612:Janus Kinases / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology*; D053683:Oncostatin M / Q000096:biosynthesis / Q000378:metabolism*; D053677:Receptors, Oncostatin M / Q000096:biosynthesis; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D053677:Receptors, Oncostatin M; D050791:STAT Transcription Factors; D053683:Oncostatin M; D053612:Janus Kinases