title: Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.
abstract: A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.
authors.affiliation: Department of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Ji
authors.forename: Darrell R
authors.initials: DR
authors.lastname: Fisher
authors.forename: Chien M
authors.initials: CM
authors.lastname: Wai