An overview of first-trimester screening for chromosomal abnormalities.
The last decade has witnessed the transformation of first-trimester Down syndrome screening from an aspiration to a clinical reality. First-trimester screening now equals or exceeds the diagnostic accuracy of conventional midtrimester screen while realizing an important desire of pregnant women for early diagnosis. Beyond the obvious benefits to individual patients, this accomplishment emphatically affirms the centrality and value of clinical research.
Bahado-Singh
Ray O
RO
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA. rbahados@med.wayne.edu
Argoti
Pedro
P
D002869:Chromosome Aberrations; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*