Lethal outcome of 5-fluorouracil infusion in a patient with a total DPD deficiency and a double DPYD and UTG1A1 gene mutation.
Mounier-Boutoille
Hélène
H
Boisdron-Celle
Michèle
M
Cauchin
Estelle
E
Galmiche
Jean-Paul
JP
Morel
Alain
A
Gamelin
Erick
E
Matysiak-Budnik
Tamara
T
D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D054067:Dihydropyrimidine Dehydrogenase Deficiency; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000235:genetics*; D017809:Fatal Outcome; D005472:Fluorouracil / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D007260:Infusion Pumps; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D008297:Male; D009154:Mutation; D010641:Phenotype; D014498:Uracil / Q000031:analogs & derivatives / Q000097:blood
D000964:Antimetabolites, Antineoplastic; C007419:dihydrouracil; D014498:Uracil; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil