Interactions of caeruloplasmin with other proteins participating in inflammation.
The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several protein-protein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP-LF complex was studied thoroughly, and evidence of reciprocal effects of CP and LF was obtained. Another specific interaction investigated in detail occurs between CP and MPO (myeloperoxidase). CP-LF, CP-MPO and CP-LF-MPO complexes were found in sera of patients with inflammation. Modelling in vitro allowed understanding of which structural peculiarities of CP and partners allow the modification of their functions in a complex. The present paper reviews the latest data on complexes of CP with LF and MPO, and advances some suggestions about their role in health and disease.
Vasilyev
Vadim B
VB
Institute of Experimental Medicine, 12 Pavlov Street, 197376 Saint Petersburg, Russia. vadim@biokemis spb.ru
D000818:Animals; D002570:Ceruloplasmin / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D018836:Inflammation Mediators / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D009195:Peroxidase / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D011485:Protein Binding / Q000502:physiology; D011506:Proteins / Q000378:metabolism* / Q000502:physiology
D018836:Inflammation Mediators; D011506:Proteins; D009195:Peroxidase; D002570:Ceruloplasmin