title: Evaluation of nonenhancing tumor fraction assessed by dynamic contrast-enhanced MRI subtraction as a predictor of decrease in tumor volume in response to chemoradiotherapy in advanced cervical cancer.
abstract: OBJECTIVE
  In this study, we evaluated the feasibility of using dynamic contrast-enhanced MRI (DCE-MRI) subtracted images as a predictor of a decrease in tumor volume in response to chemoradiotherapy in 13 patients with cervical cancer.
  
  
  CONCLUSIONS
  This study shows that pretreatment tumor nonenhancing fraction assessed with arterial image subtraction inversely predicts the chemoradiation response in cervical cancer.
authors.affiliation: Department of Radiology and Cambridge University Hospitals NHS Trust, Addenbrooke's Hospital, United Kingdom. lorenzo.mannelli@nyumc.org
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Mannelli
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Patterson
authors.forename: Mark
authors.initials: M
authors.lastname: Zahra
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Priest
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Graves
authors.forename: David J
authors.initials: DJ
authors.lastname: Lomas
authors.forename: Li Tee
authors.initials: LT
authors.lastname: Tan
authors.forename: Robin
authors.initials: R
authors.lastname: Crawford
authors.forename: James
authors.initials: J
authors.lastname: Brenton
authors.forename: Evis
authors.initials: E
authors.lastname: Sala
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA