Refining the definition of hypereosinophilic syndrome.
Because of advances in our understanding of the hypereosinophilic syndrome (HES) and the availability of novel therapeutic agents, the original criteria defining these disorders are becoming increasingly problematic. Here, we discuss shortcomings with the current definition of HES and recent developments in the classification of these disorders. Despite significant progress in our understanding of the pathogenesis of some forms of HES, the current state of knowledge is still insufficient to formulate a new comprehensive etiologic definition of HESs. Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition.
Simon
Hans-Uwe
HU
Institute of Pharmacology, University of Bern, Switzerland. hus@pki.unibe.ch
Rothenberg
Marc E
ME
Bochner
Bruce S
BS
Weller
Peter F
PF
Wardlaw
Andrew J
AJ
Wechsler
Michael E
ME
Rosenwasser
Lanny J
LJ
Roufosse
Florence
F
Gleich
Gerald J
GJ
Klion
Amy D
AD
D017681:Hypereosinophilic Syndrome / Q000145:classification* / Q000175:diagnosis; D014944:World Health Organization