title: Antibacterial activity of a triclosan-containing resin composite matrix against three common oral bacteria.
abstract: This study investigated the antibacterial effect of a resin composite matrix with or without incorporated triclosan (0.3 wt%) on Streptococcus mutans, Actinomyces viscosus and Lactobacillus casei. In the quantitative assay, bacterial suspensions were filled into 20-μl cavities within temporary restorative resins. After 0, 4, 8, 12, 24 and 48 h of incubation, the suspensions were removed from the restoratives and the numbers of viable bacteria were determined. Bacterial suspensions incubated without restoratives served as the controls. Ten replicates were carried out for each experiment. The resin composite containing triclosan demonstrated variable degrees of antibacterial activity against the microorganisms, revealing a significant inhibitory effect on S. mutans within 12 h compared to the control. The viable counts of A. viscosus significantly decreased after 24 h. A significant reduction of L. casei was observed after 48 h. The unloaded resin composite did not reveal a marked antibacterial effect. The resin composite loaded with triclosan might be beneficial in preventing cavity contamination and minimizing the risk of pulpal irritation in the short-term.
authors.affiliation: Department of Operative Dentistry and Periodontology, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany. andreas.rathke@uniklinik-ulm.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Rathke
authors.forename: Rainer
authors.initials: R
authors.lastname: Staude
authors.forename: Rainer
authors.initials: R
authors.lastname: Muche
authors.forename: Bernd
authors.initials: B
authors.lastname: Haller
mesh_terms: D016924:Actinomyces viscosus / Q000187:drug effects / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003188:Composite Resins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007780:Lacticaseibacillus casei / Q000187:drug effects / Q000254:growth & development; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D008954:Models, Biological; D009055:Mouth / Q000382:microbiology*; D012117:Resins, Synthetic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects / Q000254:growth & development; D014260:Triclosan / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D003188:Composite Resins; D004337:Drug Carriers; D012117:Resins, Synthetic; D014260:Triclosan