[A case of cervical lymph node recurrence of advanced gastric cancer responding to combination therapy of S-1, CDDP and docetaxel].
A 57-year-old man underwent total gastrectomy with D2 lymphadenectomy for advanced gastric cancer. The post operative diagnosis was Stage IIIB (tubular adenocarcinoma, moderately-differentiated type, SE, N2, M0). The patient's postoperative course was uneventful, and S-1 was administered as adjuvant chemotherapy. However, about 14 months later, a gradual left cervical lymph node swelling became evident, with an increase in the level of the tumor marker CA19-9, suggesting recurrence of the gastric cancer. After obtaining informed consent, S-1 (100 mg/body), cisplatin (60 mg/m2), and docetaxel (40 mg/m2) combination chemotherapy (DCS) was performed. After 5 courses of DCS, the patient's swollen left cervical lymph nodes became non-palpable, and also undetectable by diagnostic imaging, together with normalization of the CA19-9 level. At three months since the last chemotherapy, the patient showed no signs of recurrence. DCS is a potentially effective treatment for recurrent gastric cancer with resistance to S-1.
Sugishita
Hiroki
H
Department of Surgery, Division of Gastrointestinal Surgery and Surgical Oncology, Ehime University Graduate School of Medicine.
Ishida
Naoki
N
Yoshida
Motohira
M
Sato
Koichi
K
Doi
Takashi
T
Horiuchi
Atsushi
A
Watanabe
Yuji
Y
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D000077143:Docetaxel; D004338:Drug Combinations; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology*; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D012008:Recurrence; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use*; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D002945:Cisplatin