Select acetophenones modulate flagellar motility in chlamydomonas.
Acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, a process that requires co-ordinated flagellar motility. The structure-activity relationships of a series of acetophenones are reported, including acetophenones that affect flagellar motility and cell viability. Notably, 4-methoxyacetophenone, 3,4-dimethoxyacetophenone, and 4-hydroxyacetophenone induced negative phototaxis in Chlamydomonas, suggesting interference with activity of flagellar proteins and control of flagellar dominance.
Evans
Shakila K
SK
Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341, USA.
Pearce
Austin A
AA
Ibezim
Prudence K
PK
Primm
Todd P
TP
Gaillard
Anne R
AR
D000098:Acetophenones / Q000737:chemistry* / Q000494:pharmacology; D020418:Algal Proteins / Q000378:metabolism; D000840:Anisoles / Q000737:chemistry / Q000494:pharmacology; D002696:Chlamydomonas / Q000187:drug effects / Q000502:physiology*; D005407:Flagella / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008027:Light; D055668:Photochemical Processes; D013329:Structure-Activity Relationship
D000098:Acetophenones; D020418:Algal Proteins; D000840:Anisoles; C046029:4-acetylanisole; C031335:4-hydroxyacetophenone