title: Anxiolytic-like and sedative actions of Rollinia mucosa: possible involvement of the GABA/benzodiazepine receptor complex.
abstract: This study evaluated possible CNS effects of a hexane extract of leaves from Rollinia mucosa (Jacq.) Baill. (Annonaceae). This plant extract induced anxiolytic-like actions similar to those induced by diazepam in the avoidance exploratory behavior paradigm. Its significant activity was shown at doses from 1.62 to 6.25 mg/kg. It also enhanced pentobarbital-induced hypnosis time, and at high doses produced motor coordination impairment. The benzodiazepine (BDZ) receptor binding, evaluated by in vitro autoradiography following a single administration of R. mucosa, revealed that this plant extract reduced BDZ binding in the hippocampus (29%), amygdala (26%), and temporal cortex of mice (36%). In conclusion, the present findings support the proposal that R. mucosa may induce central nervous system (CNS) depressant effects, presumably through an interaction with the GABA/benzodiazepine receptor complex.
authors.affiliation: Instituto Nacional de Psiquiatría, México.
authors.forename: Rosa
authors.initials: R
authors.lastname: Estrada-Reyes
authors.forename: Carolina
authors.initials: C
authors.lastname: López-Rubalcava
authors.forename: Luisa
authors.initials: L
authors.lastname: Rocha
authors.forename: Gerardo
authors.initials: G
authors.lastname: Heinze
authors.forename: Alma Rosa
authors.initials: AR
authors.lastname: González Esquinca
authors.forename: Mariano
authors.initials: M
authors.lastname: Martínez-Vázquez
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010424:Pentobarbital / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D018079:Receptors, GABA / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology*; D031045:Rollinia
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D018079:Receptors, GABA; D011963:Receptors, GABA-A; D010424:Pentobarbital