[Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a meta-analysis].
OBJECTIVE
To evaluate the correlation between the gene polymorphism of IL-1beta-511 or IL-1RN VNTR and the risk of coronary heart disease (CHD).


METHODS
The patient-control studies on the association of IL-1=-511 or IL-1RN VNTR gene polymorphism with the risk of CHD were searched according to the inclusion criteria. Heterogeneity tests were conducted for the data from each study before Meta-analysis.


RESULTS
For the 7 studies addressing the correlation between IL-1beta-511 polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.04 with 95% CI of 0.93-1.18 (Z=0.71, P=0.48). For the 5 studies of the correlation between IL-1RN VNTR polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.01 and the 95% CI was 0.78-1.17 (Z=0.08, P=0.93).


CONCLUSIONS
The gene polymorphism of IL-1beta-511 or IL-1RN VNTR has no correlation to the susceptibility of CHD, but is associated with in the disease development and clinical phenotype.
Chen
Fan
F
Department of Cardiology, Xiangya Hospital, and Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha 410008, China.
Cheng
Wen
W
D000483:Alleles; D003327:Coronary Disease / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D012307:Risk Factors
D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta