title: Management of local recurrence of colorectal cancer: the role of PET/CT.
abstract: OBJECTIVE
  The aim was to examine the clinical applicability of positron-emission tomography/computed tomography (PET/CT) for diagnosing local recurrence of colorectal cancer.
  
  
  METHODS
  From August 2003 to August 2008, 256 patients with colorectal cancer underwent PET/CT scanning for staging or restaging. Local recurrence was detected in 22 patients (18 men, 4 women) postsurgically.
  
  
  RESULTS
  Of the 22 patients, 21 (95.5%) underwent positive 2-[fluorine-18]-fluoro-2-deoxy-D: -glucose uptake and were diagnosed with local recurrence by PET/CT; the results were negative in one case (4.5%). The sensitivity, specificity, positive predictive value, and negative predictive value for local recurrence were 95.5%, 100%, 100%, and 99.6%, respectively. CT/MRI scans yielded the following results: positive, 10 cases (45.5%); suspected positive, 11 cases (50.0%); negative, 1 case (4.5%). In the suspected positive cases, not only imaging but also colonoscopy and tumor markers among other techniques were used for definitive diagnosis.
  
  
  CONCLUSIONS
  PET/CT has high sensitivity and specificity for diagnosing local recurrence of colorectal cancer and would be useful especially in the case of locally recurrent colorectal cancer suspected to be positive by CT/MRI.
authors.affiliation: Department of Surgery II, Tokyo Women's Medical University, Kawadacho Shinjuku-ku, Japan. tkichi@live.jp
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Bamba
authors.forename: Michio
authors.initials: M
authors.lastname: Itabashi
authors.forename: Shingo
authors.initials: S
authors.lastname: Kameoka
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18