Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis.
Trichomonas vaginalis, a human-infectious protozoan, can display resistance to treatment by metronidazole. A library of 3,4-dichloroaniline amides based on propanil, an herbicide, has been synthesized and screened to test susceptibility to these analogs. From this preliminary study, the most effective compound 15, inhibits growth of the organism by 66% and 69% on the two strains tested, T1 and G3, respectively.
Dornbush
Padraick J
PJ
Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA.
Cho
Cynric
C
Chang
Elizabeth S
ES
Xu
Lu
L
Russu
Wade A
WA
Wrischnik
Lisa A
LA
Land
Kirkwood M
KM
D000577:Amides / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000577:Amides; D000981:Antiprotozoal Agents