Lipid A in cancer therapies preclinical results.
Studies in animal models showed that the antitumoral effect of LPS and of their biologically active moiety, lipid A, is indirect and relies on the induction of an immune response both innate and specific, leading to cytokine production. They also affect tumor development by inhibiting tumor blood flow and induce necrosis as well as apoptosis of tumor cells. Lipids A have been tested in animals, either alone or as adjuvant in therapeutic vaccines. The efficacy of treatments depends on the type of molecule and on the protocol. In general, increased survival was obtained, accompanied in some cases by tumor regression and cure.
Reisser
Daniele
D
Tumor Immunology and Immunotherapy Laboratory Inserm U866, University of Burgundy, Dijon, France.
Jeannin
Jean-François
JF
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008050:Lipid A / Q000627:therapeutic use*; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*
D008050:Lipid A