Locus dependence in epigenetic chromatin silencing.
Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.
Mukhopadhyay
Swagatam
S
BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA. swagatam@rci.rutgers.edu
Nagaraj
Vijayalakshmi H
VH
Sengupta
Anirvan M
AM
D002843:Chromatin / Q000235:genetics*; D044127:Epigenesis, Genetic; D020868:Gene Silencing; D008962:Models, Theoretical; D012441:Saccharomyces cerevisiae / Q000235:genetics
D002843:Chromatin