title: Special issue on in vitro MN trial.
abstract: In this commentary we are addressing some additional thoughts on the in vitro MN test: its predictivity for in vivo MN assays, its sensitivity, and how the choice of the cell line and the protocol (with or without cytochalasin-B) can influence these aspects. These considerations might help to make the in vitro MN test a reliable, toxicologically relevant and sensitive in vitro genotoxicity test covering both clastogenic and aneugenic events, and predictive for in vivo genotoxicity, in humans as well.
authors.affiliation: School of Medicine, University of Wales-Swansea, Swansea, United Kingdom.
authors.forename: James M
authors.initials: JM
authors.lastname: Parry
authors.forename: Micheline
authors.initials: M
authors.lastname: Kirsch-Volders
mesh_terms: D024422:Aneugens / Q000633:toxicity*; D002460:Cell Line; D003571:Cytochalasin B / Q000494:pharmacology; D005820:Genetic Testing; D017408:Guidelines as Topic; D006801:Humans; D015162:Micronucleus Tests / Q000379:methods / Q000592:standards*; D012680:Sensitivity and Specificity
chemical_list: D024422:Aneugens; D003571:Cytochalasin B