New multicomponent approach for the synthesis of benzo[c]coumarin derivatives over MgO under solvent-free conditions.
In this study, a three-component one-pot synthesis of select 5-amino-6-cyano-3-hydroxybenzo[c]coumarin compounds derived from salicylaldehydes, malononitrile, and ethyl acetoacetate is reported. The reaction is conducted on grinding over MgO at room temperature resulting in good yields.
Valizadeh
Hassan
H
Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran. h-valizadeh@azaruniv.edu
Fakhari
Ashraf
A
D000090:Acetoacetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D008277:Magnesium Oxide / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013696:Temperature
D000090:Acetoacetates; D000447:Aldehydes; D003374:Coumarins; D009570:Nitriles; D012997:Solvents; C013243:salicylaldehyde; D008277:Magnesium Oxide; C000945:dicyanmethane; C024840:ethyl acetoacetate