Sequence variation analysis of the prolactin receptor C-terminal region in women with premature ovarian failure.
Using a mouse model expressing only the PRL receptor short isoform mimicking premature ovarian failure, signaling pathways induced by PRL were analyzed in mouse ovaries. Sequencing of the coding portion of exons 10 and 11, specific to the long and short receptor isoform, respectively, did not revealed any mutation in 101 women with premature ovarian failure.
Bachelot
Anne
A
Institut National de la Santé et de la Recherche Médicale, U845, Paris, France.
Bouilly
Justine
J
Liu
Yuchen
Y
Rebourcet
Diane
D
Leux
Céline
C
Kuttenn
Frédérique
F
Touraine
Philippe
P
Binart
Nadine
N
D000328:Adult; D000818:Animals; D001483:Base Sequence; D002452:Cell Count; D004252:DNA Mutational Analysis; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009865:Oocytes / Q000166:cytology / Q000473:pathology; D016649:Primary Ovarian Insufficiency / Q000235:genetics* / Q000473:pathology; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D011981:Receptors, Prolactin / Q000737:chemistry / Q000235:genetics*
D020033:Protein Isoforms; D011981:Receptors, Prolactin