title: Uric Acid as prognostic marker in advanced nonischemic dilated cardiomyopathy: comparison with N-terminal pro B-type natriuretic peptide level.
abstract: Although uric acid (UA) level has been associated with an increased risk of cardiovascular events, it is unclear whether UA can provide greater prognostic information than N-terminal pro B-type natriuretic peptide (NT-proBNP) in advanced heart failure with nonischemic dilated cardiomyopathy (DCM). UA and NT-proBNP values were obtained from a total of 122 DCM patients. Development of clinical events during follow-up was defined as the composite of cardiac death and readmission for heart failure. During follow-up, there were 18 cardiac events. UA and NT-proBNP values were significantly higher in patients with events. The receiver operating characteristics curve showed the area under the curve for UA was greater than that for NT-proBNP. On multivariate analysis, UA remained the only independent predictor of prognosis. UA concentrations > or =8.7 mg/dL rather than NT-proBNP > or =3800 pg/mL were associated with significantly decreased event-free survival. The authors' findings demonstrated that UA value could be an informative predictor in nonischemic DCM.
authors.affiliation: Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea. khyungseop@dsmc.or.kr
authors.forename: Hyungseop
authors.initials: H
authors.lastname: Kim
authors.forename: Hong-Won
authors.initials: HW
authors.lastname: Shin
authors.forename: Jihyun
authors.initials: J
authors.lastname: Son
authors.forename: Hyuck-Jun
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Hyoung-Seob
authors.initials: HS
authors.lastname: Park
authors.forename: Yun-Kyeong
authors.initials: YK
authors.lastname: Cho
authors.forename: Choon-Duk
authors.initials: CD
authors.lastname: Han
authors.forename: Chang-Wook
authors.initials: CW
authors.lastname: Nam
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hur
authors.forename: Yoon-Nyun
authors.initials: YN
authors.lastname: Kim
authors.forename: Kwon-Bae
authors.initials: KB
authors.lastname: Kim
mesh_terms: D015415:Biomarkers; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000175:diagnosis; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006305:Health Status Indicators; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013223:Statistics as Topic; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014527:Uric Acid