title: Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor.
abstract: Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT(1A) receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT(1A)-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT(1A) receptor as well as a 5-HT(1A)-agonist activity in a 8-OH-DPAT-stimulated [(35)S]GTP-gammaS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT(1A) receptors.
authors.affiliation: Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Shin
authors.forename: Wan Kyunn
authors.initials: WK
authors.lastname: Whang
authors.forename: Sungun
authors.initials: S
authors.lastname: Kim
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Bach
authors.forename: Jin-Man
authors.initials: JM
authors.lastname: Kim
authors.forename: Xuan-Khanh Thi
authors.initials: XK
authors.lastname: Nguyen
authors.forename: Thuy-Ty Lan
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Bae Dong
authors.initials: BD
authors.lastname: Jung
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Yamada
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
authors.forename: Hyoung-Chun
authors.initials: HC
authors.lastname: Kim
mesh_terms: D000818:Animals; D002951:Citrates / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D051379:Mice; D010622:Phencyclidine / Q000633:toxicity*; D011618:Psychotic Disorders / Q000517:prevention & control*; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D012559:Schizophrenia / Q000517:prevention & control*
chemical_list: D002951:Citrates; D005960:Glucosides; C554064:parishin C; D044282:Receptor, Serotonin, 5-HT1A; D010622:Phencyclidine