title: Colchicine myopathy and neuromyopathy: two cases with different characteristics.
abstract: Colchicine, a long established anti-inflammatory agent now used in several rheumatologic conditions, acts by inhibiting microtubular polymerization, as it binds equimolarly to tubulin molecules. Cytoskeletal microtubules are crucial in processes of cell viability, such as mitosis and intracellular vesicle motility.Gastrointestinal side effects are quite common and often minor in nature or duration, whereas neuromuscular toxicity is rare. We report 2 cases of colchicine myopathy in the context of very different clinical settings.
authors.affiliation: Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy. cantariniluca@hotmail.com
authors.forename: Luca
authors.initials: L
authors.lastname: Cantarini
authors.forename: Nila
authors.initials: N
authors.lastname: Volpi
authors.forename: Mauro
authors.initials: M
authors.lastname: Galeazzi
authors.forename: Teresa
authors.initials: T
authors.lastname: Giani
authors.forename: Francesca
authors.initials: F
authors.lastname: Fanti
authors.forename: Orso Maria
authors.initials: OM
authors.lastname: Lucherini
authors.forename: Margherita
authors.initials: M
authors.lastname: Aglianò
authors.forename: Carlo
authors.initials: C
authors.lastname: Alessandrini
authors.forename: Fabio
authors.initials: F
authors.lastname: Giannini
authors.forename: Stefania
authors.initials: S
authors.lastname: Magi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Greco
authors.forename: Cosima Tatiana
authors.initials: CT
authors.lastname: Baldari
authors.forename: Rolando
authors.initials: R
authors.lastname: Cimaz
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000293:Adolescent; D015210:Arthritis, Gouty / Q000188:drug therapy; D003078:Colchicine / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D010505:Familial Mediterranean Fever / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced / Q000175:diagnosis; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis; D050257:Tubulin Modulators / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D050257:Tubulin Modulators; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D003078:Colchicine