title: Hemorrhagic leukoencephalitis linked to Epstein-Barr virus in an adult patient.
abstract: We report a case of an adult patient who presented a febrile coma linked to Epstein-Barr virus (EBV) encephalitis. EBV polymerase chain reaction (PCR) was positive in cerebrospinal fluid (CSF) and blood serology and PCR in blood was consistent with an EBV reactivation. First cerebral magnetic resonance imaging (MRI) at day 1 was normal but a second MRI at day 13 showed anomaly compatible with a hemorrhagic leukoencephalitis. Treatment consists of intravenous corticotherapy and aciclovir during 21 days. Evolution was favourable with complete neurologic recuperation and no intercurrent lymphoma or vasculitis in 6 months follow-up.
authors.affiliation: Service de Réanimation Médicale Assistance Respiratoire, Hôpital Gui de Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France. p-befort@chu-montpellier.fr
authors.forename: P
authors.initials: P
authors.lastname: Befort
authors.forename: N
authors.initials: N
authors.lastname: Gaillard
authors.forename: C
authors.initials: C
authors.lastname: Roubille
authors.forename: A Le
authors.initials: AL
authors.lastname: Quellec
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D003128:Coma / Q000209:etiology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015600:Glasgow Coma Scale; D004854:Herpesvirus 4, Human; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents; D000212:Acyclovir