title: [Predictive value of fluorescence in situ hybridization in patients with bladder cancer].
abstract: OBJECTIVE
  To assess the value of fluorescence in situ hybridization (FISH) in the diagnosis of bladder cancer.
  
  
  METHODS
  Urine samples from 100 patients suspected of having bladder cancer were collected before cystoscopy for immediate urine cytology and FISH analysis. The criteria for FISH abnormality were determined by evaluating the urine specimens from 20 subjects without urogenital neoplasm.
  
  
  RESULTS
  The overall sensitivity of cytology and FISH was 43.2% and 82.4%, and their specificity was 92.3% and 88.5%, with diagnostic concordance rate of 56.0% and 84.0%, respectively. The differences between FISH and cytology showed statistical significance in the sensitivity, diagnostic concordance rate, non-muscle-invasive cancer and primary cancer.
  
  
  CONCLUSIONS
  The sensitivity and efficiency of FISH in the detection of bladder cancer are superior to those of cytology, especially for prophase cancer.
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. shzhf0925@gmail.com
authors.forename: Zheng-fei
authors.initials: ZF
authors.lastname: Shan
authors.forename: Shao-bin
authors.initials: SB
authors.lastname: Zheng
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Wan-long
authors.initials: WL
authors.lastname: Tan
authors.forename: Yi
authors.initials: Y
authors.lastname: Zuo
authors.forename: Hai-kuan
authors.initials: HK
authors.lastname: Zhou
authors.forename: Huan
authors.initials: H
authors.lastname: Qi
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis*; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*; D014556:Urine / Q000166:cytology; D055815:Young Adult