title: The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization.
abstract: This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.
authors.affiliation: Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
authors.forename: Arthur A M
authors.initials: AA
authors.lastname: Wilde
authors.forename: Pieter G
authors.initials: PG
authors.lastname: Postema
authors.forename: José M
authors.initials: JM
authors.lastname: Di Diego
authors.forename: Sami
authors.initials: S
authors.lastname: Viskin
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Fish
authors.forename: Charles
authors.initials: C
authors.lastname: Antzelevitch
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D053840:Brugada Syndrome / Q000503:physiopathology*; D054849:Cardiac Electrophysiology / Q000379:methods; D004562:Electrocardiography; D006801:Humans