Mitochondria in the diabetic heart.
Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements in cardiac energy metabolism play an important role. In particular, abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes. This review will summarize these abnormalities in mitochondrial function and discuss potential underlying mechanisms.
Bugger
Heiko
H
Department of Cardiology, University of Freiburg, Freiburg, Germany.
Abel
E Dale
ED
D000818:Animals; D002118:Calcium / Q000378:metabolism; D048909:Diabetes Complications / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004734:Energy Metabolism; D006331:Heart Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism* / Q000473:pathology; D024101:Mitochondrial Proteins / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D011499:Protein Processing, Post-Translational; D012307:Risk Factors; D015398:Signal Transduction
D007328:Insulin; D024101:Mitochondrial Proteins; D002118:Calcium