Long-term effects of neonatal drugs on the kidney.
Several drugs have been shown to produce an adverse affect on kidneys, mainly when exposure occurred during active nephrogenesis (pregnancy or prematurity). Several experimental studies on drug-related renal injury have been done on animal models. Observational reports on early drug-related nephrotoxicity in humans are increasing. The investigations regard nephrotoxicity from antibiotics (particularly aminoglycosides), angiotensin-converting enzyme (ACE) inhibitors, non-steroidal anti-inflammatory drugs and antifungins. Few reports have been specifically on the long-term effects on kidneys of drugs given to newborns during active nephrogenesis. Most observations were targeted to investigate long-term renal effects of prematurity and intrauterine growth retardation (IUGR). Nephrotoxic medication taken during fetal life and during postnatal nephrogenesis could interfere with nephron generation contributing to a particular magnitude of damage. Such adjunctive damage could further increase the risk of renal failure in the adulthood of children born prematurely.
Zaffanello
Marco
M
Section of Pediatrics, Department of Life and Reproduction Sciences, University of Verona, Piazzale L. Scuro 10, Verona, Italy. marco.zaffanello@univr.it
Bassareo
Pier Paolo
PP
Cataldi
Luigi
L
Antonucci
Roberto
R
Biban
Paolo
P
Fanos
Vassilios
V
D000617:Aminoglycosides / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D015931:Intensive Care, Neonatal / Q000379:methods; D007674:Kidney Diseases / Q000139:chemically induced*; D013997:Time Factors
D000617:Aminoglycosides; D000894:Anti-Inflammatory Agents, Non-Steroidal