title: Lethal outcome of 5-fluorouracil infusion in a patient with a total DPD deficiency and a double DPYD and UTG1A1 gene mutation.
authors.forename: Hélène
authors.initials: H
authors.lastname: Mounier-Boutoille
authors.forename: Michèle
authors.initials: M
authors.lastname: Boisdron-Celle
authors.forename: Estelle
authors.initials: E
authors.lastname: Cauchin
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Galmiche
authors.forename: Alain
authors.initials: A
authors.lastname: Morel
authors.forename: Erick
authors.initials: E
authors.lastname: Gamelin
authors.forename: Tamara
authors.initials: T
authors.lastname: Matysiak-Budnik
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D054067:Dihydropyrimidine Dehydrogenase Deficiency; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000235:genetics*; D017809:Fatal Outcome; D005472:Fluorouracil / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D007260:Infusion Pumps; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D008297:Male; D009154:Mutation; D010641:Phenotype; D014498:Uracil / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D000964:Antimetabolites, Antineoplastic; C007419:dihydrouracil; D014498:Uracil; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil