title: Viscero-visceral hyperalgesia: characterization in different clinical models.
abstract: Co-existing algogenic conditions in two internal organs in the same patient may mutually enhance pain symptoms (viscero-visceral hyperalgesia). The present study assessed this phenomenon in different models of visceral interaction. In a prospective evaluation, patients with: (a) coronary artery disease (CAD)+gallstone (Gs) (common sensory projection: T5); (b) irritable bowel syndrome (IBS)+dysmenorrhea (Dys) (T10-L1); (c) dysmenorrhea/endometriosis+urinary calculosis (Cal)(T10-L1); and (d) gallstone+left urinary calculosis (Gs+LCal) (unknown common projection) were compared with patients with CAD, Gs, IBS, Dys or Cal only, for spontaneous symptoms (number/intensity of pain episodes) over comparable time periods and for referred symptoms (muscle hyperalgesia; pressure/electrical pain thresholds) from each visceral location. In patients' subgroups, symptoms were also re-assessed after treatment of each condition or after no treatment. (a) CAD+Gs presented more numerous/intense angina/biliary episodes and more referred muscle chest/abdominal hyperalgesia than CAD or Gs; cardiac revascularization or cholecystectomy also reduced biliary or cardiac symptoms, respectively (0.001<p<0.05). (b) IBS+Dys had more intestinal/menstrual pain and abdomino/pelvic muscle hyperalgesia than IBS or Dys; hormonal dysmenorrhea treatment also reduced IBS symptoms; IBS dietary treatment also improved dysmenorrhea (0.001<p<0.05) while no treatment of either conditions resulted in no improvement in time of symptoms from both. (c) Cal+Dys had more urinary/menstrual pain and referred lumbar/abdominal hyperalgesia than Cal or Dys; hormonal dysmenorrhea treatment/laser treatment for endometriosis also improved urinary symptoms; lithotripsy for urinary stone also reduced menstrual symptoms (0.001<p<0.05). (d) In Gs+LCal, cholecystectomy or urinary lithotripsy did not improve urinary or biliary symptoms, respectively. Mechanisms of viscero-visceral hyperalgesia between organs with documented partially common sensory projection probably involve sensitization of viscero-viscero-somatic convergent neurons.
authors.affiliation: Department of Medicine and Science of Aging, G. D'Annunzio University of Chieti, Italy Institute of Surgical Pathology, G. D'Annunzio University of Chieti, Italy.
authors.forename: Maria Adele
authors.initials: MA
authors.lastname: Giamberardino
authors.forename: Raffaele
authors.initials: R
authors.lastname: Costantini
authors.forename: Giannapia
authors.initials: G
authors.lastname: Affaitati
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fabrizio
authors.forename: Domenico
authors.initials: D
authors.lastname: Lapenna
authors.forename: Emmanuele
authors.initials: E
authors.lastname: Tafuri
authors.forename: Andrea
authors.initials: A
authors.lastname: Mezzetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy / Q000379:methods; D003109:Colonic Diseases, Functional / Q000150:complications; D004412:Dysmenorrhea / Q000150:complications / Q000628:therapy; D004715:Endometriosis / Q000150:complications; D005260:Female; D005705:Gallbladder Diseases / Q000150:complications / Q000601:surgery; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000628:therapy; D006331:Heart Diseases / Q000150:complications* / Q000628:therapy; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology* / Q000628:therapy*; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000502:physiology*; D011446:Prospective Studies; D012189:Retrospective Studies; D014545:Urinary Calculi / Q000150:complications / Q000628:therapy; D014781:Viscera / Q000503:physiopathology*; D055815:Young Adult