title: [Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance].
abstract: OBJECTIVE
  To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.
  
  
  METHODS
  PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.
  
  
  RESULTS
  PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).
  
  
  CONCLUSIONS
  Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.
authors.affiliation: Department of Urology, Zhenjiang First People's Hospital, Zhenjiang 212002, China. huamingt@126.com
authors.forename: Ming-hua
authors.initials: MH
authors.lastname: Tang
authors.forename: Jian
authors.initials: J
authors.lastname: Tan
authors.forename: Fei-lun
authors.initials: FL
authors.lastname: Cui
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D064249:Securin
chemical_list: D009363:Neoplasm Proteins; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human