title: Evaluation of Atlas based Mouse Brain Segmentation.
abstract: Magentic Reasonance Imaging for mouse phenotype study is one of the important tools to understand human diseases. In this paper, we present a fully automatic pipeline for the process of morphometric mouse brain analysis. The method is based on atlas-based tissue and regional segmentation, which was originally developed for the human brain. To evaluate our method, we conduct a qualitative and quantitative validation study as well as compare of b-spline and fluid registration methods as components in the pipeline. The validation study includes visual inspection, shape and volumetric measurements and stability of the registration methods against various parameter settings in the processing pipeline. The result shows both fluid and b-spline registration methods work well in murine settings, but the fluid registration is more stable. Additionally, we evaluated our segmentation methods by comparing volume differences between Fmr1 FXS in FVB background vs C57BL/6J mouse strains.
authors.affiliation: Department of Computer Science, University of North Carolina, Chapel Hill NC, USA.
authors.forename: Joohwi
authors.initials: J
authors.lastname: Lee
authors.forename: Julien
authors.initials: J
authors.lastname: Jomier
authors.forename: Stephen
authors.initials: S
authors.lastname: Aylward
authors.forename: Mike
authors.initials: M
authors.lastname: Tyszka
authors.forename: Sheryl
authors.initials: S
authors.lastname: Moy
authors.forename: Jean
authors.initials: J
authors.lastname: Lauder
authors.forename: Martin
authors.initials: M
authors.lastname: Styner