A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.
Kaunisto
Erik
E
Department of Chemical Engineering, LTH, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Abrahmsen-Alami
Susanna
S
Borgquist
Per
P
Larsson
Anette
A
Nilsson
Bernt
B
Axelsson
Anders
A
D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008956:Models, Chemical; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013607:Tablets
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D012997:Solvents; D013607:Tablets