title: Randomized trial of oral versus sublingual misoprostol 24 h after mifepristone for medical abortion.
abstract: OBJECTIVE
  To assess the efficacy, side effects, and acceptability of medical abortion using oral mifepristone (200 mg) followed 24 h later by oral or sublingual misoprostol (400 μg).
  
  
  METHODS
  A total of 93 women with pregnancies up to 56 days of gestational age were assigned to two groups according to the different misoprostol regimen (group I 400 μg orally and group II 400 μg sublingually). The principle outcome measure was complete abortion defined as a complete expulsion of intrauterine contents without a need for surgical intervention 7 days after the procedure.
  
  
  RESULTS
  Successful abortion occurred in 87.5% of patients in group 1 and 95.5% patients in group 2 (p = 0.166, 95% CI -0.194, 0.033). The patient acceptability and satisfaction rates were similar in both the groups.
  
  
  CONCLUSIONS
  It is concluded that 400 μg of sublingual misoprostol is as effective as oral misoprostol 24 h after mifepristone for medical abortion of ≤ 56 days.
authors.affiliation: Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, 124001, Haryana, India. krishnadahiya@rediffmail.com
authors.forename: Krishna
authors.initials: K
authors.lastname: Dahiya
authors.forename: Sonika
authors.initials: S
authors.lastname: Mann
authors.forename: Smiti
authors.initials: S
authors.lastname: Nanda
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000286:Administration, Sublingual; D000328:Adult; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone