title: [Low template DNA profiling and its application in forensic science].
abstract: Low template DNA (LTDNA) has been widely applied in the field of forensic science in recent years. However, the application of low copy number(LCN) analysis is still controversial in certain forensic. This paper focus on the definition of LCN and LTDNA, casework because of its inherent limiting factors. the validity and application of LCN in forensic science, methods of typing, quality control, replicate analysis, detection thresholds and then reviews the latest development of LCN in forensic science.
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. mayan0615@126.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.forename: Jin-zhi
authors.initials: JZ
authors.lastname: Kuang
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Hou
mesh_terms: D004247:DNA / Q000032:analysis* / Q000235:genetics; D016172:DNA Fingerprinting / Q000379:methods*; D053803:Forensic Genetics / Q000379:methods*; D018628:Gene Dosage; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods*; D012680:Sensitivity and Specificity; D013698:Templates, Genetic
chemical_list: D004247:DNA