title: Oral and oropharyngeal cancer in the West of Scotland-long-term outcome data of a prospective audit 1999-2001.
abstract: We prospectively studied patients from the west of Scotland who presented with a primary cancer of the oral cavity or oropharynx over a period of 24 months from November 1999, and report long-term outcomes and prognostic factors. A total of 481 patients had squamous cell carcinoma (SCC), 5-year disease-specific survival (DSS) was 50%, and overall survival (OS) was 35%. One hundred were not suitable for treatment with curative intent, and factors other than stage were important in this decision. Of those treated with curative intent, 249 had SCC of the oral cavity (5-year DSS 67%; OS 42%), and 132 had SCC of the oropharynx (5-year DSS 62%; OS 42%). Multivariate analysis showed that pathological nodal stage (p=0.051, 95% CI 0.998-1.955), and perineural invasion (p=0.001, 95% CI 0.186-0.666) were prognostic indicators. Improved results using intensive treatment protocols that have been seen in trials are not likely to translate directly into a general population of patients with head and neck cancer. Algorithms that allow several pathological prognostic indicators to be incorporated into decisions about adjuvant treatment should be used.
authors.affiliation: West of Scotland Managed Clinical Network for Head and Neck Cancer, UK. jeremymcmahon@nhs.net
authors.forename: J D
authors.initials: JD
authors.lastname: McMahon
authors.forename: G A J
authors.initials: GA
authors.lastname: Robertson
authors.forename: Colin
authors.initials: C
authors.lastname: Liew
authors.forename: J
authors.initials: J
authors.lastname: McManners
authors.forename: F R
authors.initials: FR
authors.lastname: Mackenzie
authors.forename: W S
authors.initials: WS
authors.lastname: Hislop
authors.forename: S E
authors.initials: SE
authors.lastname: Morley
authors.forename: J
authors.initials: J
authors.lastname: Devine
authors.forename: A T M
authors.initials: AT
authors.lastname: Carton
authors.forename: S
authors.initials: S
authors.lastname: Harvey
authors.forename: K
authors.initials: K
authors.lastname: Hunter
authors.forename: A G
authors.initials: AG
authors.lastname: Robertson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D019230:Dental Audit; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D010166:Palliative Care; D010524:Peripheral Nervous System Neoplasms / Q000556:secondary; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012372:ROC Curve; D018714:Radiotherapy, Adjuvant; D012606:Scotland / Q000453:epidemiology; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D055815:Young Adult