Prognostic impact of CD133 expression in gastric carcinoma.
OBJECTIVE
CD133 expression in cancer cells has been recognised as a putative cancer stem cell (CSC) marker in epithelial malignancies. CD133 expression was evaluated in gastric cancer and the clinical impact of CD133-positive gastric cancer was clarified.


METHODS
Ninety-seven gastric cancer patients who received curative gastrectomy were enrolled. CD133 expression in cancerous tissue was evaluated by immunohistochemistry.


RESULTS
CD133 expression positively correlated with tumour extension and the degree of nodal involvement. CD133 expression significantly affected patient postoperative outcome. Multivariate analysis revealed CD133 positivity as an independent prognostic factor superior to the depth of invasion and similar to nodal involvement in gastric cancer (p<0.05).


CONCLUSIONS
Even slight CD133 expression in gastric cancer patients may be a useful prognostic marker via CSC. Further examination of CD133 with respect to CSC markers can enable prediction of the recurrence risk of gastric cancer.
Ishigami
Sumiya
S
Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. ishiga@m.kufm.kagoshima-u.ac.jp
Ueno
Shinichi
S
Arigami
Takaaki
T
Uchikado
Yasuto
Y
Setoyama
Tetsuro
T
Arima
Hideo
H
Kita
Yoshiaki
Y
Kurahara
Hiroshi
H
Okumura
Hiroshi
H
Matsumoto
Masataka
M
Kijima
Yuko
Y
Natsugoe
Shoji
S
D000071916:AC133 Antigen; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis*; D015415:Biomarkers; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000737:chemistry*; D010455:Peptides / Q000032:analysis*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*
D000071916:AC133 Antigen; D015703:Antigens, CD; D015415:Biomarkers; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides