Racial differences in the association between sex hormone-binding globulin and adiposity in premenopausal women: the BioCycle study.
OBJECTIVE
To assess the associations between measures of adiposity and sex hormone- binding globulin (SHBG) and to evaluate whether such associations differ by race.


METHODS
Adiposity was measured by anthropometry and dual-energy X-ray absorptiometry among women (146 white, 50 black, and 25 Asian) aged 18-44 years in the BioCycle study. SHBG was repeatedly measured over one to two menstrual cycles. The ratio of trunkal to leg fat (T/L) was used to assess upper to lower body adiposity.


RESULTS
Among whites, all adiposity measures were significantly and inversely associated with SHBG. Among blacks, BMI (β = -0.032), waist circumference (β = -0.016), and T/L (β = -0.033) were significantly associated with SHBG, whereas total and trunkal fat were not (P interaction with race <0.04). Among Asians, measures of central and upper body fat were significantly associated with SHBG (e.g., T/L, β = -0.84) but not BMI.


CONCLUSIONS
Associations between SHBG and adiposity differ by race among premenopausal women.
Yeung
Edwina H
EH
Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Zhang
Cuilin
C
Hediger
Mary L
ML
Wactawski-Wende
Jean
J
Schisterman
Enrique F
EF
D015502:Absorptiometry, Photon; D050154:Adiposity / Q000208:ethnology* / Q000502:physiology*; D000328:Adult; D044383:Black People; D015992:Body Mass Index; D005260:Female; D006801:Humans; D017697:Premenopause / Q000208:ethnology* / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D044465:White People; D055815:Young Adult
D012738:Sex Hormone-Binding Globulin