title: Inward rotating spiral waves in glycolysis.
abstract: We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account.
authors.affiliation: Max-Planck-Institute for Dynamics of Complex Technical Systems, Systems Biology Group, Sandtorstr. 1, Magdeburg, Germany. rstraube@mpi-magdeburg.mpg.de
authors.forename: Ronny
authors.initials: R
authors.lastname: Straube
authors.forename: Satenik
authors.initials: S
authors.lastname: Vermeer
authors.forename: Ernesto M
authors.initials: EM
authors.lastname: Nicola
authors.forename: Thomas
authors.initials: T
authors.lastname: Mair
mesh_terms: D000494:Allosteric Regulation; D004058:Diffusion; D005656:Fungal Proteins / Q000378:metabolism; D006019:Glycolysis; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D025221:Phosphofructokinases / Q000378:metabolism; D012399:Rotation; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D009243:NAD; D025221:Phosphofructokinases