Copper-catalyzed synthesis of N-fused heterocycles through regioselective 1,2-aminothiolation of 1,1-dibromoalkenes.
The first aminothiolation of 1,1-dibromoalkene is described using an inexpensive copper/N,N-dimethylethylenediamine catalyst. The method provides a powerful means of using easily available 1,1-dihaloalkenes as precursors to fused heterocycles.
Xu
Hui
H
Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, Peoples Republic of China.
Zhang
Yin
Y
Huang
Jianqiang
J
Chen
Wanzhi
W