title: More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis.
abstract: N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment.
authors.affiliation: Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Pittaluga
authors.forename: Graziella
authors.initials: G
authors.lastname: Costa
authors.forename: Ewa
authors.initials: E
authors.lastname: Krasnowska
authors.forename: Roberto
authors.initials: R
authors.lastname: Brunelli
authors.forename: Thomas
authors.initials: T
authors.lastname: Lundeberg
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Porpora
authors.forename: Daniela
authors.initials: D
authors.lastname: Santucci
authors.forename: Tiziana
authors.initials: T
authors.lastname: Parasassi
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D054697:Cytostatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004715:Endometriosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000235:genetics; D018836:Inflammation Mediators / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010532:Peritoneal Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D000975:Antioxidants; D054697:Cytostatic Agents; D018836:Inflammation Mediators; D000111:Acetylcysteine