Aneuploidies in embryos and spermatozoa from patients with Y chromosome microdeletions.
In patients with Y chromosome microdeletions and high percentage of numeric chromosome abnormalities detected by fluorescence in situ hybridization on sperm, a high percentage of abnormal embryos was observed compared with oligozoospermic patients without Y chromosome microdeletions, with a significant increase in the percentage of embryos with monosomy X. Differences in fertilization rates between the different patient groups were not observed; however, blastocyst rates were significantly impaired in patients with Y chromosome microdeletions.
Mateu
Emilia
E
Instituto Valenciano de Infertilidad, Valencia, Spain. emateu@ivi.es
Rodrigo
Lorena
L
Martínez
M Carmen
MC
Peinado
Vanessa
V
Milán
Miguel
M
Gil-Salom
Manuel
M
Martínez-Jabaloyas
Jose Maria
JM
Remohí
José
J
Pellicer
Antonio
A
Rubio
Carmen
C
D000328:Adult; D000782:Aneuploidy; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics; D004622:Embryo, Mammalian / Q000002:abnormalities / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007248:Infertility, Male; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000235:genetics / Q000473:pathology; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities / Q000378:metabolism* / Q000473:pathology; D016896:Treatment Outcome