title: Novel vitamin and gold-loaded nanofiber facial mask for topical delivery.
abstract: L-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid content of the mask may oxidize some of the unstable active ingredients such as ascorbic acid. This work presents an anti-wrinkle nanofiber face mask containing ascorbic acid, retinoic acid, gold nanoparticles, and collagen. This novel face mask will only be wetted when applied to the skin, thus enhancing product stability. Once moistened, the content of the mask will gradually dissolve and release the active ingredients and ensure maximum skin penetration. The high surface area-to-volume ratio of the nanofiber mask will ensure maximum contact with the skin surface and help to enhance the skin permeation to restore its healthy appearance. Electrospun fiber mats may provide an attractive alternative to the commercial facial cotton masks.
authors.affiliation: Department of Pharmacy, National University of Singapore, Block S4, level 2, Science Drive 4, 117543, Singapore, Singapore.
authors.forename: Anahita
authors.initials: A
authors.lastname: Fathi-Azarbayjani
authors.forename: Lin
authors.initials: L
authors.lastname: Qun
authors.forename: Yew Weng
authors.initials: YW
authors.lastname: Chan
authors.forename: Sui Yung
authors.initials: SY
authors.lastname: Chan
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D008397:Masks; D049329:Nanostructures / Q000737:chemistry*; D012867:Skin / Q000737:chemistry*
chemical_list: D003879:Dermatologic Agents; D004337:Drug Carriers; D006046:Gold; D001205:Ascorbic Acid