Regulation of alternative splicing by short non-coding nuclear RNAs.
Recent results from deep-sequencing and tiling array studies indicated the existence of a large number of short, metabolically stable, non-coding RNAs. Some of these short RNAs derive from known RNA classes like snoRNA or tRNAs. There are intriguing similarities between short non-coding nuclear RNAs and oligonucleotides used to change alternative splicing events, which usually target a disease-relevant RNA. We review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection.
Khanna
Amit
A
University of Kentucky, Molecular and Cellular Biochemistry, South Limestone, Lexington, KY, USA.
Stamm
Stefan
S
D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D009841:Oligonucleotides / Q000378:metabolism; D022821:RNA Splice Sites; D058727:RNA, Small Untranslated / Q000378:metabolism*; D017423:Sequence Analysis, RNA
D009841:Oligonucleotides; D022821:RNA Splice Sites; D058727:RNA, Small Untranslated