Severe polyuria and polydipsia in hyponatremic-hypertensive syndrome associated with Wilms tumor.
The combination of hyponatremia and renovascular hypertension is known as hyponatremic-hypertensive syndrome (HHS) and so rarely described in children but associated with various kinds of occlusions of the renal artery. We describe two children who presented HHS with severe hypokalemia, polyuria, and polydipsia associated with Wilms tumor, which required treatment with an angiotensin-converting enzyme inhibitor before nephrectomy. All HHS signs and symptoms resolved only following surgical resection of the tumor, allowing chemotherapy to be given.
D'Angelo
Paolo
P
Unit of Pediatric Hematology and Oncology, G. Di Cristina Children's Hospital, A.R.N.A.S., Palermo, Italy. oncoematoped@ospedalecivicopa.org
Catania
Serena
S
Zirilli
Giusy
G
Collini
Paola
P
Tropia
Serena
S
Perotti
Daniela
D
Terenziani
Monica
M
Spreafico
Filippo
F
D002675:Child, Preschool; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications*; D007010:Hyponatremia / Q000150:complications*; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications*; D008297:Male; D011141:Polyuria / Q000150:complications*; D013577:Syndrome; D013894:Thirst; D009396:Wilms Tumor / Q000150:complications*