Statistical methods for integrating multiple types of high-throughput data.
Large-scale sequencing, copy number, mRNA, and protein data have given great promise to the biomedical research, while posing great challenges to data management and data analysis. Integrating different types of high-throughput data from diverse sources can increase the statistical power of data analysis and provide deeper biological understanding. This chapter uses two biomedical research examples to illustrate why there is an urgent need to develop reliable and robust methods for integrating the heterogeneous data. We then introduce and review some recently developed statistical methods for integrative analysis for both statistical inference and classification purposes. Finally, we present some useful public access databases and program code to facilitate the integrative analysis in practice.
Xie
Yang
Y
Division of Biostatistics, Department of Clinical Sciences, The Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ahn
Chul
C
D056808:Biostatistics / Q000379:methods*; D002965:Classification; D003627:Data Interpretation, Statistical; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis