title: Peroxyl radical scavenging activity of the antihypertensive drug carvedilol.
abstract: The antihypertensive drug carvedilol was tested for its ability to scavenge peroxyl radicals by use of the model radical trichloromethyl peroxyl (CC1(3)O(2)). Carvedilol scavenged CC1(3)O(2) with a calculated rate constant of 1.5 +- 0.1 x 10(7)/M(-1) sec(-1). This ability to react rapidly with peroxyl radicals might be one mechanism by which carvedilol inhibits lipid peroxidation accounting for its reported antioxidant activity.
authors.affiliation: Pharmacology Group, University of London King's College, Manresa Road, London SW3 6LX, UK.
authors.forename: O I
authors.initials: OI
authors.lastname: Aruoma