[Correlation between FOXP3 gene polymorphisms and allergic rhinitis].
OBJECTIVE
To investigate the correlation between polymorphisms in the FOXP3 locus and the susceptibility of allergic rhinitis.


METHODS
Two polymorphisms in FOXP3 locus were genotyped in 193 subjects with allergic rhinitis and 191 healthy controls. The polymorphisms were chosen in terms of the information from Hapmap website as well as Haploview version 4.1 program implemented results. PCR-resequencing methods was performed for genotyping. SPSS program version 13.0 was used for statistical analysis.


RESULTS
Heterozygotes of rs3761547 and rs3761548 appeared significant, while only rs3761548 (P = 0.020, OR = 3.12, 95%CI were 1.21 - 8.04) remained significant following application of the Bonferroni correction for multiple testing. Subgroup analysis for the presence of different allergen allergy also showed significant association for house dust mites (rs3761547, P = 0.013, OR = 2.00).


CONCLUSIONS
Heterozygous allele in rs3761548 is associated with allergic rhinitis and rs3761547 is related to house dust mites allergic rhinitis.
Zhang
Yuan
Y
Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology, Head and Neck Surgery (Capital Medical University), Ministry of Education, Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Affilitiated to Capital Medical University, Beijing, China.
Wang
Cheng-shuo
CS
Zhang
Luo
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics*; D055815:Young Adult
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors