title: Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation.
abstract: We present a case of a 12-year-old female with a germline TP53 mutation who presented with anaplastic astrocytoma and subsequent acute lymphoblastic leukemia (ALL) 13 months after starting treatment with temozolomide (TMZ). The patient had no family history of malignancy except her grand father and his siblings. Although alkylating agents such as TMZ are known to induce secondary hematologic malignancy, only several cases of treatment-related acute leukemia have been reported after TMZ-alone chemotherapy for malignant gliomas. We demonstrate a rare case of TMZ-related ALL in a child with glioma possibly associated with a germline TP53 mutation.
authors.affiliation: Neurosurgery Division, National Cancer Center Hospital, Tokyo, Japan. momota-nsu@umin.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Momota
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Narita
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nariata
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Miyakita
authors.forename: Ako
authors.initials: A
authors.lastname: Hosono
authors.forename: Atsushi
authors.initials: A
authors.lastname: Makimoto
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shibui
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D001254:Astrocytoma / Q000188:drug therapy* / Q000235:genetics; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics; D002648:Child; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005625:Frontal Lobe; D016158:Genes, p53 / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000139:chemically induced*; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide