Post-elution concentration of (188)Re by an electrochemical method.
High specific activity (188)Re required for nuclear medicine is mostly obtained from (188)W/(188)Re generators. As the parent radionuclide (188)W is of low specific activity (<185 GBq/g), a relatively large volume of 0.9% saline is required for the elution of (188)Re. Post-elution concentration is needed in order to increase the radioactive concentration of the eluted (188)Re. An electrochemical procedure to concentrate (188)Re suitable for the preparation of radiopharmaceuticals is developed. (188)Re eluted from an alumina generator could be concentrated approximately 100 fold, and it could be used to label DMSA and HEDP with >98% yield.
Chakravarty
Rubel
R
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Dash
Ashutosh
A
Pillai
M R A
MR
Venkatesh
Meera
M
D004563:Electrochemistry / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D013051:Spectrometry, Gamma
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium