title: Action of an antioxidant complex on the antioxidant power of saliva.
abstract: OBJECTIVE
  Based on the results of the soluble antioxidants test (SAT), we have produced a combination of oral antioxidants aimed at increasing the antioxidant power of saliva. Several antioxidants are included in this product (Vit E, beta-carotene, Vit A, Vit C, polyphenols, cathechins, ellagic acid, anthocyanins, coenzyme Q10 and pyridoxine in association with Se, Zn, L-cysteine). The aim of this registry study was to evaluate the efficacy of these antioxidants in saliva, plasma and urines.
  
  
  METHODS
  MF Odontovis, an antioxidant complex, was administered to healthy subjects in the evening for one week with a final administration in the morning.
  
  
  RESULTS
  Plasma, urine and saliva showed an increase in antioxidant power following both the evening administration and the final morning administration. The antioxidant action appeared to be present even at night when salival secretion is lower. Plasma SAT levels (SATs) in the morning following evening treatment were increased by 21% in comparison with controls. Morning administration increased levels up to 34% when measured 4 hours after treatment. Comparable increases were observed in saliva (SATs and morning values were +44 %; +58% two hours after morning administration and +28 % after 4 hours). In urine the evening administration caused an increase in antioxidant power (+6%).
  
  
  CONCLUSIONS
  This study indicated that antioxidant levels can be increased with specific nutritional supplement. The clinical value of an increased antioxidant power in biological fluids, particularly in saliva, may be relevant for future trials of prevention and treatment.
authors.affiliation: Loyola University School of Medicine, Chicago, IL, USA. umbertocornelli@cornelliconsulting.it
authors.forename: U
authors.initials: U
authors.lastname: Cornelli
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: G M
authors.initials: GM
authors.lastname: Nardi
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: M
authors.initials: M
authors.lastname: Dugall
authors.forename: M
authors.initials: M
authors.lastname: Hosoi
authors.forename: M G
authors.initials: MG
authors.lastname: Grossi
authors.forename: E
authors.initials: E
authors.lastname: Ippolito
authors.forename: A
authors.initials: A
authors.lastname: Ledda
authors.forename: I
authors.initials: I
authors.lastname: Ruffini
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D052756:Nutritional Sciences; D010919:Placebos; D012463:Saliva / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D010919:Placebos