[New insights into acute lymphoblastic leukemia].
Acute lymphoblastic leukemia is a malignant disorder of lymphoid progenitor cells. Advances in our understanding of lymphoblastic leukemia have mainly come from new molecular technologies and genomics. This article describes recent advances in our understanding of maturation arrest of leukemic cells, initial and subsequent gene defects and rearrangements, the role of chemokines, and lymphoid cell homing. These advances point to new ways of targeting leukemic cells.
Landman-Parker
Judith
J
Hématologie et Oncologie Pédiatrique, Hôpital Armand Trousseau, 26 avenue du Dr A. Netter, 75571 Paris cedex 12. judith.landman-parker@trs.aphp.fr
Pagès
Perle
P
Petit
Arnaud
A
Fasola
Sylvie
S
Leverger
Guy
G
D000293:Adolescent; D002471:Cell Transformation, Neoplastic; D018925:Chemokines / Q000502:physiology; D002648:Child; D002869:Chromosome Aberrations; D004200:Diseases in Twins; D005260:Female; D005315:Fetal Diseases / Q000235:genetics / Q000473:pathology; D005330:Fetofetal Transfusion; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000196:embryology / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D011247:Pregnancy; D054400:Receptors, CCR7 / Q000502:physiology
C515370:CCR7 protein, human; D018925:Chemokines; D054400:Receptors, CCR7