title: Automated synthesis of a 96 product-sized library of triazole derivatives using a solid phase supported copper catalyst.
abstract: This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
authors.affiliation: Laboratoire de Pharmacologie Chimique et Génétique (UMR 8151 CNRS, U 1022 INSERM, IFR 2769), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech; 11, rue Pierre et Marie Curie, 75005 Paris, France. ibtissemj@yahoo.fr
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Jlalia
authors.forename: Claire
authors.initials: C
authors.lastname: Beauvineau
authors.forename: Sophie
authors.initials: S
authors.lastname: Beauvière
authors.forename: Esra
authors.initials: E
authors.lastname: Onen
authors.forename: Marie
authors.initials: M
authors.lastname: Aufort
authors.forename: Aymeric
authors.initials: A
authors.lastname: Beauvineau
authors.forename: Eihab
authors.initials: E
authors.lastname: Khaba
authors.forename: Jean
authors.initials: J
authors.lastname: Herscovici
authors.forename: Faouzi
authors.initials: F
authors.lastname: Meganem
authors.forename: Christian
authors.initials: C
authors.lastname: Girard
mesh_terms: D001331:Automation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D005374:Filtration; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D054852:Small Molecule Libraries; D014230:Triazoles; D003300:Copper