title: High-intensity interval training in an adolescent with cystic fibrosis: a physiological perspective.
abstract: Nutritional, musculoskeletal, and/or ventilatory status can lead to a decreased exercise capacity in children with cystic fibrosis (CF). Exercise training is already part of the usual care; however, the "optimal" intensity and volume of exercise training to improve exercise capacity is still unknown. Six weeks of high-intensity interval training (HIT) for a patient with CF with a ventilatory limitation was evaluated by a cardiopulmonary exercise test (CPET). Peak oxygen uptake and peak workload increased 19% and 16%, respectively, and there was a rise in peak ventilation from 50 L/min to 75 L/min, with an increase in both breathing depth and respiratory rate. A relative short period of HIT resulted in a significant increase in exercise capacity. In patients with CF, HIT might be an effective and efficient training regimen, especially in CF patients with a ventilatory limitation. Further research is necessary to investigate whether HIT is a better alternative than traditional aerobic training programs especially in ventilatory limited patients with CF.
authors.affiliation: Child Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. h.hulzebos@umcutrecht.nl
authors.forename: H J
authors.initials: HJ
authors.lastname: Hulzebos
authors.forename: H
authors.initials: H
authors.lastname: Snieder
authors.forename: J
authors.initials: J
authors.lastname: van der Et
authors.forename: P J
authors.initials: PJ
authors.lastname: Helders
authors.forename: T
authors.initials: T
authors.lastname: Takken
mesh_terms: D000293:Adolescent; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000534:rehabilitation*; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010101:Oxygen Consumption; D012123:Pulmonary Ventilation; D020127:Recovery of Function; D015656:Respiratory Mechanics; D013997:Time Factors; D016896:Treatment Outcome