Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children.
The P2X7 gene polymorphisms have been linked to increased risk for pulmonary and extrapulmonary tuberculosis in some populations. In this study, the genotype and allelic frequencies 1513A-->C variant within the P2X7 gene was significantly higher than in the healthy controls (P = 0.035, P = 0.041). This is the first study demonstrating that the 1513A-->C polymorphism is associated with extrapulmonary tuberculosis in children.
Tekin
Deniz
D
Institute of Forensic Medicine, Ankara University, Ankara, Turkey. drdeniztekin@yahoo.com
Kayaalti
Zeliha
Z
Dalgic
Nazan
N
Cakir
Erkan
E
Soylemezoglu
Tulin
T
Isin Kutlubay
Busra
B
Aydin Kilic
Betul
B
D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D058486:Receptors, Purinergic P2X7; D014376:Tuberculosis / Q000235:genetics*; D014421:Turkey
C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7