[Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1 (corrected)].
The onset of schizophrenia symptoms typically occurs in young adulthood. It most commonly manifests as hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking. Schizophrenia is often accompanied by social or occupational dysfunction. Recent genetic studies revealed several probable susceptibility genes for schizophrenia such as Neuregulin1, Dysbindin and Disrupted-in-Schizophrenia-1 (DISC1). DISC1 was originally identified as the sole gene that associated with a high inheritance of schizophrenia and other psychiatric illnesses in a large Scottish family. We here review the recent advance in understanding of pathophysiological functions of DISC1. [corrected]
Kaibuchi
Kozo
K
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, 466-8550 Japan. kaibuchi@med.nagoya-u.ac.jp
Tsuboi
Daisuke
D
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D016547:Kinesins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000502:physiology*; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
C412476:DISC1 protein, human; C488101:KIF5B protein, human; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016547:Kinesins