title: Bisbenzamidines as antifungal agents. are both amidine functions required to observe an anti-Pneumocystis carinii activity?
abstract: A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 microg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 microg/mL.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Sciences, University of Mons-UMONS, 20 place du parc, B-7000 Mons, Belgium.
authors.forename: Julien
authors.initials: J
authors.lastname: Laurent
authors.forename: Dimitri
authors.initials: D
authors.lastname: Stanicki
authors.forename: Tien L
authors.initials: TL
authors.lastname: Huang
authors.forename: Eduardo
authors.initials: E
authors.lastname: Dei-Cas
authors.forename: Muriel
authors.initials: M
authors.lastname: Pottier
authors.forename: El Mouktar
authors.initials: el M
authors.lastname: Aliouat
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Vanden Eynde
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001550:Benzamidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D045363:Pneumocystis carinii / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D001550:Benzamidines