Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy.
Two oil-in-water formulations, containing equal amounts of apigenin-enriched chamomile flower extracts, for potential use as topical antiinflammatory agents, were prepared and their physicochemical properties evaluated. A pilot clinical study was then carried out to assess patient acceptability and efficacy. The creams were either non-liposomal or liposomal. The liposomal formulations were more viscous, thus producing superior release characteristics in vitro. The clinical study also showed that the liposomal creams were, as antiinflammatory agents, slightly more effective in vivo than the non-liposomal formulations. These results suggest that there is scope for the further development of even more effective and safer alternatives to corticosteroids.
Arsić
Ivana
I
Institute for Medicinal Plants Research 'Dr Josif Pančić', Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
Tadić
Vanja
V
Vlaović
Djordje
D
Homšek
Irena
I
Vesić
Sonja
S
Isailović
Gorana
G
Vuleta
Gordana
G
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D047310:Apigenin / Q000008:administration & dosage* / Q000494:pharmacology; D020843:Chamomile / Q000737:chemistry; D003877:Dermatitis, Contact / Q000188:drug therapy; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage* / Q000494:pharmacology; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D012867:Skin / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D008081:Liposomes; D009824:Ointments; D010936:Plant Extracts; D047310:Apigenin