Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome.
This study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms.
Xiao
Lin
L
Department of Oral & Maxillofacial Surgery, Central Hospital of Fuling, Chongqing, China.
Ng
Tzi Bun
TB
Feng
Yi-Bin
YB
Yao
Tong
T
Wong
Jack Ho
JH
Yao
Ren-Min
RM
Li
Lei
L
Mo
Fei-Zhi
FZ
Xiao
Yin
Y
Shaw
Pang-Chui
PC
Li
Ze-Min
ZM
Sze
Stephen Cho Wing
SC
Zhang
Kalin Yanbo
KY
D000818:Animals; D051402:Aquaporin 5 / Q000378:metabolism*; D001706:Biopsy; D031667:Dendrobium; D005260:Female; D006801:Humans; D008046:Lip; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012463:Saliva / Q000378:metabolism*; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000188:drug therapy / Q000378:metabolism*
D051402:Aquaporin 5; D010936:Plant Extracts