title: Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.
abstract: Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131, Napoli, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Chianese
authors.forename: Serge R
authors.initials: SR
authors.lastname: Yerbanga
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lucantoni
authors.forename: Annette
authors.initials: A
authors.lastname: Habluetzel
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Basilico
authors.forename: Donatella
authors.initials: D
authors.lastname: Taramelli
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031601:Azadirachta / Q000737:chemistry*; D002050:Burkina Faso; D005638:Fruit / Q000737:chemistry; D036701:Limonins / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D036701:Limonins; D014315:Triterpenes; C487479:azadirone; C552230:neemfruitin A; C552231:neemfruitin B; C106014:gedunin