title: Trimethoprim-sulfamethoxazole-induced Stevens-Johnson syndrome: a case report.
abstract: Stevens-Johnson syndrome and toxic epidermal necrolysis are rare; however, when they occur, they usually present with severe reactions in response to medications and other stimuli. These reactions are characterized by mucocutaneous lesions, which ultimately lead to epidermal death and sloughing. We present a unique case report of Stevens-Johnson syndrome and associated toxic epidermal necrolysis in a 61-year-old man after treatment for a peripherally inserted central catheter infection with trimethoprim-sulfamethoxazole. This case report reviews a rare adverse reaction to a commonly prescribed antibiotic drug used in podiatric medical practice for the management of diabetic foot infections.
authors.affiliation: Orthopaedics/Division of Podiatric Medicine and Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Langlois
authors.forename: Francis
authors.initials: F
authors.lastname: Derk
authors.forename: Ronald
authors.initials: R
authors.lastname: Belczyk
authors.forename: Thomas
authors.initials: T
authors.lastname: Zgonis
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D017719:Diabetic Foot / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy / Q000601:surgery; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000209:etiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination