title: In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated Candidiasis.
abstract: The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.
authors.affiliation: Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium.
authors.forename: Sona
authors.initials: S
authors.lastname: Kucharíková
authors.forename: Hélène
authors.initials: H
authors.lastname: Tournu
authors.forename: Michelle
authors.initials: M
authors.lastname: Holtappels
authors.forename: Patrick
authors.initials: P
authors.lastname: Van Dijck
authors.forename: Katrien
authors.initials: K
authors.lastname: Lagrou
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology; D057785:Catheters / Q000009:adverse effects* / Q000382:microbiology*; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin