title: Extramedullary hematopoiesis and paraplegia in a patient with hemoglobin e-Beta thalassemia.
abstract: Extramedullary hematopoiesis (EMH) occurs in patients with various hematologic disorders involving a chronic increase in the production of red blood cells, and is often associated polycythemia vera and sickle cell anaemia, but is less common with thalassemia especially with hemoglobin E-beta thalassemia. Spinal cord compression due to EMH is a extremely rare complication of thalassemia and may present with paraparesis or paraplegia with or without sensory impairment. Treatment options mostly include surgery and/or radiotherapy. Whereas cases presenting with paraplegia have been treated with either surgery or radiotherapy with equal frequency and efficacy, almost all reported cases with paraplegia have been treated with surgery with or without radiation therapy. We hereby report a case of hemoglobin E-beta thalassemia with paraplegia treated successfully with radiotherapy.
authors.affiliation: Department of Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.
authors.forename: M R
authors.initials: MR
authors.lastname: Alam
authors.forename: M S
authors.initials: MS
authors.lastname: Habib
authors.forename: G P
authors.initials: GP
authors.lastname: Dhakal
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.forename: M A
authors.initials: MA
authors.lastname: Rahim
authors.forename: A J
authors.initials: AJ
authors.lastname: Chowdhury
authors.forename: T K
authors.initials: TK
authors.lastname: Mahmud
mesh_terms: D000328:Adult; D006411:Hematopoiesis, Extramedullary; D006446:Hemoglobin E; D006801:Humans; D008297:Male; D010264:Paraplegia / Q000209:etiology / Q000532:radiotherapy*; D013117:Spinal Cord Compression / Q000209:etiology / Q000532:radiotherapy*; D017086:beta-Thalassemia / Q000150:complications / Q000532:radiotherapy*
chemical_list: D006446:Hemoglobin E