Adherence to the dietary guidelines for Americans and endometrial cancer risk.
The Healthy Eating Index (HEI) was developed by the US Department of Agriculture with the goal of quantifying adherence to the Dietary Guidelines for Americans. The purpose of this study was to evaluate the impact of the HEI-2005 score and each of its components on endometrial cancer risk in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed a Food Frequency Questionnaire, which was used to derive the HEI-2005 score. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression while adjusting for potential covariates, which included all major endometrial cancer risk factors. The adjusted OR for women in the highest quartile when compared to the lowest quartile was 0.83 (95% CI: 0.52-1.34). For the meat and beans component comprising meat, eggs, poultry, fish, and beans, the OR was 0.70 (95% CI: 0.45-1.11; p for trend: 0.07), with little evidence of an association with any of the individual foods. There was no indication of an association for any of the other components of the HEI or of effect modification by body mass index. This study suggested limited value for the HEI-2005 in predicting endometrial cancer risk.
Chandran
Urmila
U
The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany St., New Brunswick, NJ 08903, USA.
Bandera
Elisa V
EV
Williams-King
Melony G
MG
Sima
Camelia
C
Bayuga
Sharon
S
Pulick
Katherine
K
Wilcox
Homer
H
Zauber
Ann G
AG
Olson
Sara H
SH
D015992:Body Mass Index; D016022:Case-Control Studies; D004032:Diet; D004435:Eating; D016889:Endometrial Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005502:Food; D019983:Guideline Adherence; D006801:Humans; D016015:Logistic Models; D008460:Meat; D009515:New Jersey / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires