title: Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.
abstract: Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain.
authors.affiliation: School of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Yoo Lim
authors.initials: YL
authors.lastname: Kam
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Rhee
authors.forename: Hyewhon
authors.initials: H
authors.lastname: Rhim
authors.forename: Seung Keun
authors.initials: SK
authors.lastname: Back
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Na
authors.forename: Hea-Young Park
authors.initials: HY
authors.lastname: Choo
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D020747:Calcium Channels, T-Type / Q000378:metabolism*; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
chemical_list: D000700:Analgesics; D020747:Calcium Channels, T-Type; D010879:Piperazines