Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial.
In 36 women with polycystic ovary syndrome and clomiphene citrate resistance, letrozole, an aromatase inhibitor, statistically significantly increased the ovulation rate by 33.3% in the treatment group, indicating that letrozole can be used as an effective and simple alternate ovulation-inducing agent in these women.
Kamath
Mohan S
MS
Reproductive Medicine Unit, Christian Medical College, Vellore, Tamil Nadu, India.
Aleyamma
T K
TK
Chandy
Achamma
A
George
Korula
K
D000328:Adult; D047072:Aromatase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D004351:Drug Resistance / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000188:drug therapy*; D000077289:Letrozole; D009570:Nitriles / Q000494:pharmacology / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D017211:Treatment Failure; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
D047072:Aromatase Inhibitors; D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole