Imaging-genetics applications in child psychiatry.
OBJECTIVE
To place imaging-genetics research in the context of child psychiatry.


METHODS
A conceptual overview is provided, followed by discussion of specific research examples.


RESULTS
Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.


CONCLUSIONS
Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.
Pine
Daniel S
DS
National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA. daniel.pine@nih.gov
Ernst
Monique
M
Leibenluft
Ellen
E
D000293:Adolescent; D000818:Animals; D001921:Brain / Q000503:physiopathology; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D008995:Monoamine Oxidase / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase