[Some special characteristics of vascular reactivity in heart failure].
We determined parameters of elasticity of peripheral arteries in patients with heart failure (HF) including those with pulmonary arterial hypertension. We also investigated pulmonary artery responses to vasoconstricting factors in vitro. Reactivity of the aorta and carotid artery was studied on the model of experimental HF. Lowering of elasticity of small arteries progressed with worsening of HF functional class and increase of pulmonary arterial hypertension. In the genesis of pulmonary hypertension definite role played elevated constrictor response of pulmonary artery to endothelin 1 at the background of dysfunction of endothelial ETB receptors. Endothelial dependent reactivity of the aorta and carotid artery was impaired and their constrictor effect augmented.
Popovich
M I
MI
Kobets
V A
VA
Chebanu
N V
NV
Ivanov
V M
VM
Todirash
M P
MP
Popovich
I M
IM
Moraru
I L
IL
Chebanu
L M
LM
D015897:Comorbidity; D018450:Disease Progression; D004548:Elasticity; D065131:Endothelin B Receptor Antagonists; D019332:Endothelin-1 / Q000494:pharmacology; D023381:Endpoint Determination; D006333:Heart Failure / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000503:physiopathology; D044023:Receptor, Endothelin B / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D065131:Endothelin B Receptor Antagonists; D019332:Endothelin-1; D044023:Receptor, Endothelin B; D014662:Vasoconstrictor Agents