title: Bioactivity of aviprin and aviprin-3''-O-glucoside, two linear furanocoumarins from Apiaceae.
abstract: Furanocoumarins are well-known natural products that occur in the most evolved genera of Apiaceae family. This compounds were found to have cytotoxic, phytotoxic, photosensitizing, insecticidal, antibacterial and high anti-fungal effects. Aviprin is considered as a linear furanocoumarin substituted at C8 with an oxygenated prenyl residue. In this study we found that aviprin is a bioactive compound that exhibits high antibacterial, antifungal and phytotoxic activity. The compound stunted the germination of lettuce seeds with IC50 value of 0.270 mg/mL. The compound also inhibited the mycelia growth of Sclerotinia sclerotiorum. Aviprin indicated antibacterial activity against tested gram negative and positive bacteria with inhibition zone of 19-23.5 mm. Our results shown that aviprin can play an allelopatic role for plant.
authors.affiliation: Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. razavi694@gmail.com
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Razavi
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Zarrini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects / Q000254:growth & development; D003374:Coumarins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005663:Furans / Q000494:pharmacology*; D018525:Germination / Q000187:drug effects; D005960:Glucosides / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D018545:Lactuca / Q000187:drug effects / Q000196:embryology; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D012639:Seeds / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D005663:Furans; D005960:Glucosides; C462035:aviprin; C551226:aviprin-3''-O-glucoside