[Study of follicle-stimulating hormone receptor and tyrosine hydroxylase polymorphisms and pre-eclampsia in Chinese Han population].
OBJECTIVE
To analyze a potential association of gene polymorphisms of the follicle-stimulating hormone receptor (FSHR) gene rs1394205 polymorphism and tyrosine hydroxylase (TH) rs2070762 polymorphism with pre-eclampsia.


METHODS
The gene polymorphism of FSHR rs1394205 and TH rs2070762 were analyzed by real-time Quantitative polymerase chain reaction (TaqMan probe) in 105 patients with pre-eclampsia and 103 healthy pregnant subjects in Chinese Han population. Genotype and allele were assessed by direct counting methods. And the associations between 2 SNPs and pre-eclampsia were analyzed by chi-square test.


RESULTS
The frequencies of the TH gene rs2070762 polymorphism CC, C/T and TT genotypes were 14.6%, 42.7% and 42.7% in pre-eclampsia group and 18.1%, 56.2% and 25.7% in normal control group respectively. The allelic frequency of rs2070762 polymorphism in TH in pre-eclampsia patients was significantly lower (P < 0.05) than that in normal pregnancies. There was a significant difference between two groups (P < 0.05). But there was no significant difference between mild and severe pre-eclampsia groups (P > 0.05). In contrast, no significant association was detected in the comparison of genotypes and allele of FSHR gene rs1394205 between pre-eclampsia patients and normal pregnancies.


CONCLUSIONS
The TH rs2070762 polymorphism was associated with the pathogenesis of pre-eclampsia. It suggests that the polymorphism in TH may be involved in the onset and development of pre-eclampsia.
Chen
Ying
Y
Changchun Obstetrics & Gynecology Hospital, Changchun 130042, China.
Tong
Xiao-hong
XH
Sun
Cheng-juan
CJ
Zhang
Wei-yuan
WY
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011962:Receptors, FSH / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D011962:Receptors, FSH; D014446:Tyrosine 3-Monooxygenase