title: Individual and combined effects of foods on Helicobacter pylori growth.
abstract: Eradication of H. pylori can reduce the risk of non-cardia gastric cancer developing in infected humans. Thus, the consumption of foods that inhibit the growth of these bacteria may provide an alternative to current therapies that include antibiotics, proton pump inhibitors and/or bismuth salts. This study describes a simple broth dilution assay developed to screen a range of foods for their individual and combined effects on H. pylori growth. It was found that foods with measurable anti-H. pylori activity have an effect greater in combination than the sum of foods tested singly, and that this was most noticeable with a combination of broccoli sprouts and blackcurrant oil. The results suggest that food synergy should be considered in any nutraceutical approach to H. pylori infection.
authors.affiliation: Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand. jacqui.keenan@otago.ac.nz
authors.forename: Jacqueline I
authors.initials: JI
authors.lastname: Keenan
authors.forename: Nina
authors.initials: N
authors.lastname: Salm
authors.forename: Mark B
authors.initials: MB
authors.lastname: Hampton
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Wallace
mesh_terms: D001937:Brassica / Q000737:chemistry; D055951:Functional Food; D016481:Helicobacter Infections / Q000178:diet therapy*; D016480:Helicobacter pylori / Q000254:growth & development*; D006722:Honey; D008826:Microbial Sensitivity Tests