Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.
Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines.
Aldrich
Leslie N
LN
Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA.
Stoops
Sydney L
SL
Crews
Brenda C
BC
Marnett
Lawrence J
LJ
Lindsley
Craig W
CW
D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*
D011758:Pyrroles; C551403:tambjamine K