title: Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation.
abstract: The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.
authors.affiliation: State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, 210096, Nanjing, China. xuewang@seu.edu.cn.
authors.forename: Dadong
authors.initials: D
authors.lastname: Guo
authors.forename: Chunhui
authors.initials: C
authors.lastname: Wu
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Li
authors.forename: Airong
authors.initials: A
authors.lastname: Guo
authors.forename: Qingning
authors.initials: Q
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Baoan
authors.initials: B
authors.lastname: Chen
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang