title: A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.
abstract: A new 1,1-dichlorocyclopropane-containing angucycline, JBIR-88 (1), and a new butenolide, JBIR-89 (2), respectively, were isolated from the fermentation broths of two lichen-derived actinomycetes identified as a new species of Streptomyces (strains RI104-LiC106 and RI104-LiB101) using phylogenetic methods. The structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compound 1 showed cytotoxic activities against cancer cells and antimicrobial activity against Micrococcus luteus.
authors.affiliation: Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), Tokyo, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Motohashi
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008011:Lichens / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D016982:Micrococcus luteus / Q000187:drug effects; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013302:Streptomyces / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D011809:Quinones; D012336:RNA, Ribosomal, 16S; C004511:butenolide; D015107:4-Butyrolactone