title: Doxycycline failure in lymphogranuloma venereum.
abstract: Lymphogranuloma venereum (LGV) cases are currently re-emerging in the homosexual community, particularly in HIV-seropositive patients. The standard treatment for this infection, which is caused by Chlamydia trachomatis L1, L2 and L3 serotypes, is a 3-week doxycycline regimen. The case is reported of a male patient presenting with LGV, who was rapidly cured with moxifloxacin treatment after failure of extended treatment with cyclines. This fluoroquinolone is known to be highly active in vitro on the LGV pathogenic agent. Thus it may be a useful alternative when doxycycline treatment results in failure.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hôpital d'Instruction des Armées Bégin, Saint Mandé 94160, France. mechaifrederic@wanadoo.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Méchaï
authors.forename: Bertille
authors.initials: B
authors.lastname: de Barbeyrac
authors.forename: Olivier
authors.initials: O
authors.lastname: Aoun
authors.forename: Audrey
authors.initials: A
authors.lastname: Mérens
authors.forename: Patrick
authors.initials: P
authors.lastname: Imbert
authors.forename: Christophe
authors.initials: C
authors.lastname: Rapp
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use*; D024841:Fluoroquinolones; D018451:Homosexuality, Male; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000188:drug therapy*; D008297:Male; D000077266:Moxifloxacin; D011349:Proctitis / Q000382:microbiology; D011804:Quinolines / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D004318:Doxycycline; D000077266:Moxifloxacin