title: Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection.
abstract: CE with capacitively coupled contactless conductivity detection (C(4)D) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-beta-cyclodextrin (HPbetaCD) in a 75 mM acetic acid+25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for C(4)D and UV were 1.3 and 1.0 ppm, respectively. The effects of HPbetaCD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed.
authors.affiliation: Centre for Forensic Science, Department of Chemistry and Forensic Science, University of Technology Sydney (UTS), Sydney, Australia.
authors.forename: Rochelle
authors.initials: R
authors.lastname: Epple
authors.forename: Lucas
authors.initials: L
authors.lastname: Blanes
authors.forename: Alison
authors.initials: A
authors.lastname: Beavis
authors.forename: Claude
authors.initials: C
authors.lastname: Roux
authors.forename: Philip
authors.initials: P
authors.lastname: Doble
mesh_terms: D000662:Amphetamines / Q000737:chemistry / Q000302:isolation & purification*; D000697:Central Nervous System Stimulants / Q000737:chemistry / Q000302:isolation & purification*; D004553:Electric Conductivity; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D057230:Limit of Detection
chemical_list: D000662:Amphetamines; D000697:Central Nervous System Stimulants