[Clinical multivariate regression analysis of local recurrence following curative surgery for rectal cancer].
OBJECTIVE
To investigate the clinicopathologic factors related to local recurrence following curative surgery for rectal cancer and explore the ways to improve the efficacies.


METHODS
A total of 257 post-operative cases of rectal cancers from January 1995 to December 2002 were recruited. And the relation of each clinicopathologic characteristic and local post-operative recurrence was retrospectively investigated. The clinicopathologic factors and follow-up data were analyzed by uni and multi-factorial regression model by logistic regression.


RESULTS
The total local recurrence rate of rectal cancer after radical operation was 18.7%, 75.0% (36/48) within 2 years and 95.8% (45/48) within 3 years, the median time was 14.6 months (range: 2-63). Univariate analysis showed that age, Dukes' stage, lymph node metastasis and level of CEA were significantly associated with the local post-operative recurrence (P<0.05). Multivariate analysis showed that age and lymph node metastasis were closely related with the local post-operative recurrence (P<0.05).


CONCLUSIONS
Lymph node metastasis and age are very important prognostic factors for the local post-operative recurrence. It is possible to improve the prognosis of rectum cancer by making an early diagnosis and offering a scientific standard therapy.
Zhao
Wei-min
WM
Department of Abdominal Tumor Surgery, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
Yang
Xin-hui
XH
Wang
Hai-jiang
HJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology*; D009367:Neoplasm Staging; D011184:Postoperative Period; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D012044:Regression Analysis; D055815:Young Adult