Brain disorders: getting 'Down' to the gene.
Narrowing down the genetic basis of Down syndrome, in which hundreds of genes are triplicated, has been difficult. A new study finds that the expression of two affected genes, Olig1 and Olig2, is critical for maintaining the balance of inhibitory and excitatory signaling in a mouse model of Down syndrome.
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D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D001927:Brain Diseases / Q000235:genetics*; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D000076104:Oligodendrocyte Transcription Factor 2
D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; C494786:Olig1 protein, mouse; C512773:Olig2 protein, mouse