title: Sulfachlorpyrazine residues depletion in turkey edible tissues.
abstract: Sulfachlorpyrazine (SCP) is currently used to treat coccidian infections in turkeys; however, there is no information available about the withdrawal period necessary for the turkey to be safe for human consumption. A high performance liquid chromatography method with ultraviolet-visible light detection was adapted and validated for the determination of SCP in turkey tissues. The procedure is based on isolation of the (SCP sodium) compound from edible turkey tissues (muscles, liver, kidneys, and fat with skin) with satisfactory recovery (72.80 +/- 1.40) and specificity. The residue depletion of SCP in turkeys was conducted after a dose of 50 mg/kg body weight/day had been administrated orally for 3 days. After treatment has been discontinued residue concentrations were detected in tissues on the 7th day. The highest SCP concentrations were measured in muscles. Based on the results presented in this study, it could be assumed that a withdrawal period of 21 days, before medicated turkeys could be slaughtered, would be sufficient to ensure consumer safety.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland. beata-lebkowska@o2.pl
authors.forename: B I
authors.initials: BI
authors.lastname: Łebkowska-Wieruszewska
authors.forename: C J
authors.initials: CJ
authors.lastname: Kowalski
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004350:Drug Residues / Q000032:analysis* / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D016014:Linear Models; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D011897:Random Allocation; D012867:Skin / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism; D013424:Sulfanilamides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D014422:Turkeys / Q000378:metabolism*; D000096926:Benzenesulfonamides
chemical_list: D000890:Anti-Infective Agents; D013424:Sulfanilamides; C050643:sulfachlorpyrazine; D000096926:Benzenesulfonamides