Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases.
OBJECTIVE
The aims of this study were to evaluate survival and ovarian prognosis in patients treated for ovarian germ cell tumor (OGCT) and to propose a decision-making protocol.


METHODS
Charts of girls operated on for OGCT from 1976 up to 2009 were reviewed retrospectively. Tumor characteristics were assessed by tumor markers, imaging, and pathology.


RESULTS
Charts were available in 71 children presenting 75 OGCT. Tumors were benign in 58 cases and malignant in 17 cases. The average of the largest diameter of benign OGCT was significantly lower than that of malignant OGCT (76.5 +/- 49 mm versus 169 +/- 54 mm, P < .0001). Ovarian-sparing tumorectomy was carried out in 27 benign OGCT; 23 (85%) preserved ovaries were follicular. Malignant OGCTs were managed according to the protocols of the French Society for Pediatric Oncology. Bilateral oophorectomy had to be performed in 2 children. One patient presented a recurrence and 1 died.


CONCLUSIONS
In our series, both benign and malignant OGCTs have a good prognosis. A 75-mm cutoff size is proposed as an important criterion to preoperatively differentiate between benign and malignant tumors. In benign OGCT, ovarian-sparing tumorectomy leads to preserve ovaries in approximately 85% of cases, and in malignant OGCT, high survival rate has been obtained.
Vaysse
Charlotte
C
Department of Pediatric Surgery, Childen's Hospital, 31059 Toulouse Cedex 9, France. pvaysse@cict.fr
Delsol
Martine
M
Carfagna
Luana
L
Bouali
Ourdia
O
Combelles
Sophie
S
Lemasson
Frederique
F
Le Mandat
Aurélie
A
Castex
Marie-Pierre
MP
Pasquet
Marlène
M
Moscovici
Jacques
J
Guitard
Jacques
J
Pienkowski
Catherine
C
Rubie
Hervé
H
Galinier
Philippe
P
Vaysse
Philippe
P
D000293:Adolescent; D014408:Biomarkers, Tumor; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D007223:Infant; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D010052:Ovariectomy; D011379:Prognosis; D012189:Retrospective Studies
D014408:Biomarkers, Tumor