Transient elastography in the assessment of liver fibrosis in adult thalassemia patients.
Transient elastography (TE) is a valuable noninvasive technique of measuring liver stiffness and a reliable tool for predicting hepatic fibrosis in patients with chronic liver disease. The role of TE in patients with beta-thalassemia has not been extensively investigated. The present study aimed to evaluate the role of TE in the assessment of hepatic fibrosis in 115 adult patients with beta-thalassemia major (TM) (#59) or intermedia (TI) (#56). TE was performed according to current practice. Histologic data were obtained in 14 cases. Liver iron concentration was assessed by atomic absorption spectrometry and T2 magnetic resonance. In patients with TM, the proportion of anti-HCV positive viremic patients, median serum ferritin levels, and TE values were significantly higher than in TI. In the group of 14 patients who underwent liver biopsy, a significant positive correlation was observed between liver stiffness and fibrosis stage (r = 0.73, P = 0.003). Severe fibrosis is diagnosed with a sensitivity of 60% and a specificity of 89%, whereas cirrhosis is detected with a sensitivity of 100% and a specificity of 92%. At multivariate analysis, the variables independently associated with TE were ALT, GGT, and bilirubin levels in both groups and, in patients with TM, HCV RNA positivity. In beta-thalassemia patients, TE is a reliable tool for assessing liver fibrosis even if the influence of iron overload has to be clarified.
Fraquelli
Mirella
M
Second Division of Gastroenterology, Foundation IRCCS Cà Granda, Maggiore Policlinico Hospital and University of Milan, Milan, Italy.
Cassinerio
Elena
E
Roghi
Alberto
A
Rigamonti
Cristina
C
Casazza
Giovanni
G
Colombo
Massimo
M
Massironi
Sara
S
Conte
Dario
D
Cappellini
Maria Domenica
MD
D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D005260:Female; D005293:Ferritins / Q000032:analysis; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D019190:Iron Overload / Q000209:etiology / Q000473:pathology; D007558:Italy; D008099:Liver / Q000737:chemistry / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D016037:Single-Blind Method; D065227:Transfusion Reaction; D014766:Viremia / Q000150:complications; D055815:Young Adult; D017086:beta-Thalassemia / Q000150:complications*
D005293:Ferritins; D007501:Iron