title: PPARα contributes to colonic protection in mice with DSS-induced colitis.
abstract: Inflammatory bowel disease (IBD) is characterized by repeated chronic inflammation of the gastrointestinal tract. We have used the complementary model of colonic inflammation to examine the roles of peroxisome proliferator-activated receptor α (PPARα) in colonic inflammation and thus its possible role in IBD. We characterized an innate immune-mediated model of colitis induced by dextran sulfate sodium (DSS). Mice with DSS-induced colitis were injected with Wy-14643 (2 mg/kg) as a PPARα agonist every day from day 0 to day 5. We show that mice given Wy-14643 were less susceptible to experimental acute colitis induced by DSS, and this decreased susceptibility was correlated with decreased production of IFNγ, IL-1β, IL-6, and TNF-α. Our findings suggest that PPARα has a role in controlling colonic inflammation and mucosal tissue homeostasis.
authors.affiliation: Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Izumisano, Osaka 598-8531, Japan. azuma@vet.osakafu-u.ac.jp
authors.forename: Yasu-Taka
authors.initials: YT
authors.lastname: Azuma
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kuwamura
authors.forename: Ai
authors.initials: A
authors.lastname: Morioka
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Nakajima
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D051379:Mice; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D047493:PPAR alpha; D011743:Pyrimidines; C006253:pirinixic acid; D016264:Dextran Sulfate