title: Relative contribution of lipids and apolipoproteins to incident coronary heart disease and ischemic stroke: the PRIME Study.
abstract: OBJECTIVE
  To compare within the same cohort the association of a large panel of lipids with the risk of incident coronary heart disease (CHD) and ischemic stroke events in participants of the Prospective Epidemiological Study of Myocardial Infarction.
  
  
  METHODS
  In this binational (Northern Ireland and France) prospective cohort, we considered 9,711 men aged 50-59 years free of CHD and stroke at baseline (1991-1993). The hazard ratios of each lipid marker for CHD and ischemic stroke events were estimated in separate Cox proportional hazard models adjusted for age, study center, systolic blood pressure, antihypertensive treatment, current smoking status, body mass index and diabetes.
  
  
  RESULTS
  After 10 years of follow-up, 635 men had a first CHD and 98 a first ischemic stroke event. Total cholesterol (total-C), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, triglycerides, apolipoprotein (Apo) A1 and Apo B100, their ratios and lipoprotein (a) [Lp(a)] were all significantly predictive of future CHD. Associations with ischemic stroke followed the same trend as for CHD, but with lower strength, and none were statistically significant. However, none of the differences between the hazard ratios for CHD and for ischemic stroke were statistically significant.
  
  
  CONCLUSIONS
  In healthy, middle-aged men, total-C, HDL-C, LDL-C, non-HDL-C, triglycerides, Apo A1 and Apo B100, their ratios and Lp(a) are, if anything, weak predictors of ischemic stroke events over a 10-year period.
authors.affiliation: INSERM, U970, Paris Cardiovascular Research Center, Université Paris Descartes, UMR-S970, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Canouï-Poitrine
authors.forename: Gerald
authors.initials: G
authors.lastname: Luc
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Bard
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrieres
authors.forename: John
authors.initials: J
authors.lastname: Yarnell
authors.forename: Dominique
authors.initials: D
authors.lastname: Arveiler
authors.forename: Pierre
authors.initials: P
authors.lastname: Morange
authors.forename: Frank
authors.initials: F
authors.lastname: Kee
authors.forename: Alun
authors.initials: A
authors.lastname: Evans
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Pierre
authors.initials: P
authors.lastname: Ducimetiere
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Empana
mesh_terms: D016632:Apolipoprotein A-I / Q000097:blood; D053299:Apolipoprotein B-100 / Q000097:blood; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology*; D005602:France / Q000453:epidemiology; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000453:epidemiology*; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol