Endothelins and their receptors as biological markers for oral cancer.
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies recognized nowadays, and represents a public health problem. Its early detection is the better alternative to provide a good quality of life for the patients. During the last years, several studies have identified potential biomarkers of OSCC progression and prognosis. Endothelins and their receptors are involved in several pathophysiological conditions and in various cancer types. The present review article discusses whether the endothelin system would represent a biomarker for OSCC.
Hoffmann
Renata R
RR
Postgraduate Program of Dental College, PUCRS, Pontifícia Universidade Católica do Rio Grande do Sul, Partenon, Porto Alegre, Brazil.
Yurgel
Liliane S
LS
Campos
Maria M
MM
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D055088:Early Detection of Cancer; D016232:Endothelins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D017466:Receptors, Endothelin / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; D016232:Endothelins; D017466:Receptors, Endothelin