title: 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema.
abstract: BACKGROUND
  We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.
  
  
  OBJECTIVE
  To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010).
  
  
  METHODS
  The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review.
  
  
  RESULTS
  This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference.
  
  
  CONCLUSIONS
  Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.
authors.affiliation: Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada. tbowen@pol.net.
authors.forename: Tom
authors.initials: T
authors.lastname: Bowen
authors.forename: Marco
authors.initials: M
authors.lastname: Cicardi
authors.forename: Henriette
authors.initials: H
authors.lastname: Farkas
authors.forename: Konrad
authors.initials: K
authors.lastname: Bork
authors.forename: Hilary J
authors.initials: HJ
authors.lastname: Longhurst
authors.forename: Bruce
authors.initials: B
authors.lastname: Zuraw
authors.forename: Emel
authors.initials: E
authors.lastname: Aygoeren-Pürsün
authors.forename: Timothy
authors.initials: T
authors.lastname: Craig
authors.forename: Karen
authors.initials: K
authors.lastname: Binkley
authors.forename: Jacques
authors.initials: J
authors.lastname: Hebert
authors.forename: Bruce
authors.initials: B
authors.lastname: Ritchie
authors.forename: Laurence
authors.initials: L
authors.lastname: Bouillet
authors.forename: Stephen
authors.initials: S
authors.lastname: Betschel
authors.forename: Della
authors.initials: D
authors.lastname: Cogar
authors.forename: John
authors.initials: J
authors.lastname: Dean
authors.forename: Ramachand
authors.initials: R
authors.lastname: Devaraj
authors.forename: Azza
authors.initials: A
authors.lastname: Hamed
authors.forename: Palinder
authors.initials: P
authors.lastname: Kamra
authors.forename: Paul K
authors.initials: PK
authors.lastname: Keith
authors.forename: Gina
authors.initials: G
authors.lastname: Lacuesta
authors.forename: Eric
authors.initials: E
authors.lastname: Leith
authors.forename: Harriet
authors.initials: H
authors.lastname: Lyons
authors.forename: Sean
authors.initials: S
authors.lastname: Mace
authors.forename: Barbara
authors.initials: B
authors.lastname: Mako
authors.forename: Doris
authors.initials: D
authors.lastname: Neurath
authors.forename: Man-Chiu
authors.initials: MC
authors.lastname: Poon
authors.forename: Georges-Etienne
authors.initials: GE
authors.lastname: Rivard
authors.forename: Robert
authors.initials: R
authors.lastname: Schellenberg
authors.forename: Dereth
authors.initials: D
authors.lastname: Rowan
authors.forename: Anne
authors.initials: A
authors.lastname: Rowe
authors.forename: Donald
authors.initials: D
authors.lastname: Stark
authors.forename: Smeeksha
authors.initials: S
authors.lastname: Sur
authors.forename: Ellie
authors.initials: E
authors.lastname: Tsai
authors.forename: Richard
authors.initials: R
authors.lastname: Warrington
authors.forename: Susan
authors.initials: S
authors.lastname: Waserman
authors.forename: Rohan
authors.initials: R
authors.lastname: Ameratunga
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bernstein
authors.forename: Janne
authors.initials: J
authors.lastname: Björkander
authors.forename: Kristylea
authors.initials: K
authors.lastname: Brosz
authors.forename: John
authors.initials: J
authors.lastname: Brosz
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
authors.forename: Teresa
authors.initials: T
authors.lastname: Caballero
authors.forename: Mike
authors.initials: M
authors.lastname: Frank
authors.forename: George
authors.initials: G
authors.lastname: Fust
authors.forename: George
authors.initials: G
authors.lastname: Harmat
authors.forename: Amin
authors.initials: A
authors.lastname: Kanani
authors.forename: Wolfhart
authors.initials: W
authors.lastname: Kreuz
authors.forename: Marcel
authors.initials: M
authors.lastname: Levi
authors.forename: Henry
authors.initials: H
authors.lastname: Li
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Martinez-Saguer
authors.forename: Dumitru
authors.initials: D
authors.lastname: Moldovan
authors.forename: Istvan
authors.initials: I
authors.lastname: Nagy
authors.forename: Erik W
authors.initials: EW
authors.lastname: Nielsen
authors.forename: Patrik
authors.initials: P
authors.lastname: Nordenfelt
authors.forename: Avner
authors.initials: A
authors.lastname: Reshef
authors.forename: Eva
authors.initials: E
authors.lastname: Rusicke
authors.forename: Sarah
authors.initials: S
authors.lastname: Smith-Foltz
authors.forename: Peter
authors.initials: P
authors.lastname: Späth
authors.forename: Lilian
authors.initials: L
authors.lastname: Varga
authors.forename: Zhi Yu
authors.initials: ZY
authors.lastname: Xiang