title: Synthesis and vasodilative activity of tanshinone IIA derivatives.
abstract: A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotanshinone (D(2)) were also prepared in this work. Vasodilation activity in vitro of them was valuated on the contractile response of vascular thoracic aorta smooth muscle from Wistar rats for the first time. Most of them exhibited a concentration-dependent inhibition on the contractile response of norepinephrine.
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, PR China.
authors.forename: Yue-Feng
authors.initials: YF
authors.lastname: Bi
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Xu
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Liu
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Zhen-Ji
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D045784:Abietanes; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D010616:Phenanthrenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D045784:Abietanes; D010616:Phenanthrenes; D014665:Vasodilator Agents; C021751:tanshinone; C037886:cryptotanshinone; D009638:Norepinephrine