title: Toxicity study of Vernonia cinerea.
abstract: The methanol extract of Vernonia cinerea Less (Asteraceae), which exhibited antimicrobial activity, was tested for toxicity. In an acute toxicity study using mice, the median lethal dose (LD(50)) of the extract was greater than 2000 mg/kg, and we found no pathological changes in macroscopic examination by necropsy of mice treated with extract. As well as the oral acute toxicity study, the brine shrimp lethality test was also done. Brine shrimp test LC(50) values were 3.87 mg/mL (6 h) and 2.72 mg/mL (24 h), exhibiting no significant toxicity result. In conclusion, the methanol extract of V. cinerea did not produce toxic effects in mice and brine shrimp.
authors.affiliation: School of Biological Sciences, University Science of Malaysia, Minden, Penang, Malaysia.
authors.forename: L Yoga
authors.initials: LY
authors.lastname: Latha
authors.forename: I
authors.initials: I
authors.lastname: Darah
authors.forename: K
authors.initials: K
authors.lastname: Jain
authors.forename: S
authors.initials: S
authors.lastname: Sasidharan
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D018517:Plant Roots; D035741:Vernonia
chemical_list: D010936:Plant Extracts