title: Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age.
abstract: Effective treatment with nasal continuous positive airway pressure (nCPAP) lowers blood pressure (BP) in patients with obstructive sleep apnea (OSA). It was reported that OSA might influence BP in middle-aged but not in elderly patients. However, effects of nCPAP treatment in elderly hypertensive OSA patients are not well known. We investigated long-term compliance with nCPAP and its effects on BP in elderly and middle-aged OSA patients. This observational study involved 92 OSA patients (81 men, 11 women; 46 middle-aged, 46 elderly; body mass index (BMI), 27.7 (27.0-28.7) kg m(-2); apnea hypopnea index, 43.0 (39.4-46.6) per h; 95% confidence intervals). BP and BMI were measured before the study and at two checkpoints after usage of nCPAP (616 (553-679) and 1048 (985-1114) days). Diastolic BP decreased by 5.69 (3.09-8.29) mm Hg after 600 days of nCPAP treatment and by 4.50 (1.80-7.19) mm Hg after 1000 days (P=0.003). There were no significant changes in systolic BP, BMI or usage time of nCPAP. With a daily average of 3 h or more of nCPAP treatment, diastolic BP decreased significantly in subject groups ≥ 60 and <60 years of age. Even in the elderly, a daily average use of nCPAP for 3 h would lower diastolic BP in OSA patients.
authors.affiliation: Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
authors.forename: Kensaku
authors.initials: K
authors.lastname: Aihara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chin
authors.forename: Toru
authors.initials: T
authors.lastname: Oga
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Takefumi
authors.initials: T
authors.lastname: Hitomi
authors.forename: Misa
authors.initials: M
authors.lastname: Takegami
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Handa
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Tsuboi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents