Endogenous carbon monoxide production in disease.
Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or endogenously. Endogenous production, carboxyhemoglobin (COHb) formation, and exhaled CO levels are influenced by physiological factors, including disease. It is suggested that endogenous CO production can be used as a biomarker for oxidative and inflammatory processes. Also, endogenous CO can contribute to increased body burden of CO, which may both disrupt normal CO signaling cascades and increase the risk of CO toxicity.
Owens
Elizabeth Oesterling
EO
National Center for Environmental Assessment, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Mailcode B-243-01, Research Triangle Park, NC 27711, USA. owens.beth@epa.gov
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism*; D002263:Carboxyhemoglobin / Q000378:metabolism; D004194:Disease; D006801:Humans
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin