title: In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes.
abstract: N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).
authors.affiliation: Clinica di Medicina del Lavoro Università di Ancona, Ospedale di Torrette, 60020 Torrette di Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Governa
authors.forename: M
authors.initials: M
authors.lastname: Valentino
authors.forename: F
authors.initials: F
authors.lastname: Monaco
authors.forename: I
authors.initials: I
authors.lastname: Visoná
authors.forename: M
authors.initials: M
authors.lastname: Amati