title: Diffusion-weighted MRI of malignant pleural mesothelioma: preliminary assessment of apparent diffusion coefficient in histologic subtypes.
abstract: OBJECTIVE
  The purpose of this study was to prospectively assess, in the evaluation of patients with suspected malignant pleural mesothelioma (MPM), apparent diffusion coefficient (ADC) values derived from diffusion-weighted images obtained with a free-breathing single-shot spin-echo echo-planar imaging sequence and to correlate the ADC values with the three histologic subtypes of MPM.
  
  
  METHODS
  Sixty-two patients with a known pleural abnormality and clinical findings suggestive of MPM underwent diffusion-weighted 3-T MRI and ADC calculation. The pathologic diagnosis was confirmed by surgical procedure. ADC values were correlated with the histologic subtypes of MPM. Statistical analysis was performed with analysis of variance and the Student's t test.
  
  
  RESULTS
  Fifty-seven patients had MPM. Forty of the tumors were epithelioid, 11 were biphasic, and six were sarcomatoid. The other five patients had pleural thickening (two patients), metastatic adenocarcinoma (one patient), chronic inflammation (one patient), and malignant lymphoma (one patient). Because of image distortion, the diffusion-weighted images and ADC maps were not satisfactory for assessment in seven cases. The ADC values of MPM were 1.31 +/- 0.15 x 10(-3) mm(2)/s for the epithelioid, 1.01 +/- 0.11 x 10(-3) mm(2)/s for the biphasic, and 0.99 +/- 0.07 x 10(-3) mm(2)/s for the sarcomatoid subtypes of MPM. The ADC of the epithelioid subtype was statistically significantly higher than that of the sarcomatoid subtype (p < 0.05). The ADC in the two cases of benign plaque was 0.85 +/- 0.17 x 10(-3) mm(2)/s.
  
  
  CONCLUSIONS
  The ADC values of epithelioid mesothelioma are higher than those of sarcomatoid mesothelioma. There is no significant difference between the ACD values of biphasic and those of sarcomatoid MPM.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA. rgill@partners.org
authors.forename: Ritu R
authors.initials: RR
authors.lastname: Gill
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Umeoka
authors.forename: Hatsuho
authors.initials: H
authors.lastname: Mamata
authors.forename: Tamara R
authors.initials: TR
authors.lastname: Tilleman
authors.forename: Peter
authors.initials: P
authors.lastname: Stanwell
authors.forename: Reiko
authors.initials: R
authors.lastname: Woodhams
authors.forename: Robert F
authors.initials: RF
authors.lastname: Padera
authors.forename: David J
authors.initials: DJ
authors.lastname: Sugarbaker
authors.forename: Hiroto
authors.initials: H
authors.lastname: Hatabu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008654:Mesothelioma / Q000145:classification* / Q000473:pathology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000145:classification* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity