Synthesis of MUC1-lipopeptide chimeras.
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation strategy.
Wilkinson
Brendan L
BL
School of Chemistry, University of Sydney, NSW 2006, Australia.
Malins
Lara R
LR
Chun
Candy K Y
CK
Payne
Richard J
RJ
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry* / Q000276:immunology; D055666:Lipopeptides / Q000737:chemistry* / Q000276:immunology; D015394:Molecular Structure; D018396:Mucin-1 / Q000737:chemistry* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000276:immunology
D015295:Antigens, Tumor-Associated, Carbohydrate; D055666:Lipopeptides; D018396:Mucin-1; D014614:Vaccines, Synthetic