title: A genotype and phenotype database of genetically modified malaria-parasites.
abstract: The RMgm database, www.pberghei.eu, is a web-based, manually curated, repository containing information on genetically modified rodent-malaria parasites. It provides easy and rapid access to information on the genotype and phenotype of mutant and reporter parasites. The database also contains information on unpublished mutants without a clear phenotype and negative trials to disrupt genes. Information can be searched using pre-defined key features, such as phenotype, life-cycle stage, gene model, gene-tags and mutations. The information relating to the mutants is reciprocally linked to PlasmoDB and GeneDB. Access to mutant-parasite information, and gene function/ontology inferred from mutant phenotypes provides a timely resource aimed at enhancing research into Plasmodium gene function and (systems) biology.
authors.affiliation: Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre (LUMC), Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. c.j.janse@lumc.nl
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Janse
authors.forename: Hans
authors.initials: H
authors.lastname: Kroeze
authors.forename: Auke
authors.initials: A
authors.lastname: van Wigcheren
authors.forename: Senad
authors.initials: S
authors.lastname: Mededovic
authors.forename: Jannik
authors.initials: J
authors.lastname: Fonager
authors.forename: Blandine
authors.initials: B
authors.lastname: Franke-Fayard
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Waters
authors.forename: Shahid M
authors.initials: SM
authors.lastname: Khan
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D004195:Disease Models, Animal; D005838:Genotype; D008288:Malaria / Q000469:parasitology; D009154:Mutation / Q000235:genetics; D030781:Organisms, Genetically Modified; D010641:Phenotype; D010961:Plasmodium / Q000235:genetics*