2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema.
BACKGROUND
We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.


OBJECTIVE
To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010).


METHODS
The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review.


RESULTS
This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference.


CONCLUSIONS
Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.
Bowen
Tom
T
Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada. tbowen@pol.net.
Cicardi
Marco
M
Farkas
Henriette
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Bork
Konrad
K
Longhurst
Hilary J
HJ
Zuraw
Bruce
B
Aygoeren-Pürsün
Emel
E
Craig
Timothy
T
Binkley
Karen
K
Hebert
Jacques
J
Ritchie
Bruce
B
Bouillet
Laurence
L
Betschel
Stephen
S
Cogar
Della
D
Dean
John
J
Devaraj
Ramachand
R
Hamed
Azza
A
Kamra
Palinder
P
Keith
Paul K
PK
Lacuesta
Gina
G
Leith
Eric
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Lyons
Harriet
H
Mace
Sean
S
Mako
Barbara
B
Neurath
Doris
D
Poon
Man-Chiu
MC
Rivard
Georges-Etienne
GE
Schellenberg
Robert
R
Rowan
Dereth
D
Rowe
Anne
A
Stark
Donald
D
Sur
Smeeksha
S
Tsai
Ellie
E
Warrington
Richard
R
Waserman
Susan
S
Ameratunga
Rohan
R
Bernstein
Jonathan
J
Björkander
Janne
J
Brosz
Kristylea
K
Brosz
John
J
Bygum
Anette
A
Caballero
Teresa
T
Frank
Mike
M
Fust
George
G
Harmat
George
G
Kanani
Amin
A
Kreuz
Wolfhart
W
Levi
Marcel
M
Li
Henry
H
Martinez-Saguer
Inmaculada
I
Moldovan
Dumitru
D
Nagy
Istvan
I
Nielsen
Erik W
EW
Nordenfelt
Patrik
P
Reshef
Avner
A
Rusicke
Eva
E
Smith-Foltz
Sarah
S
Späth
Peter
P
Varga
Lilian
L
Xiang
Zhi Yu
ZY