title: Primary ciliary dyskinesia that responded to long-term, low-dose clarithromycin.
abstract: A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls. Otitis media and decreased spermatic motor ability were identified. In addition, electron microscopy of a biopsy specimen of the nasal mucosa showed a deficiency of inner dynein. Based on these clinical findings, primary ciliary dyskinesia (PCD) was diagnosed and successfully treated with long-term, low-dose clarithromycin. Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD.
authors.affiliation: The Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshioka
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kakugawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D017291:Clarithromycin / Q000008:administration & dosage*; D006801:Humans; D007619:Kartagener Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017291:Clarithromycin