title: Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children.
abstract: The P2X7 gene polymorphisms have been linked to increased risk for pulmonary and extrapulmonary tuberculosis in some populations. In this study, the genotype and allelic frequencies 1513A-->C variant within the P2X7 gene was significantly higher than in the healthy controls (P = 0.035, P = 0.041). This is the first study demonstrating that the 1513A-->C polymorphism is associated with extrapulmonary tuberculosis in children.
authors.affiliation: Institute of Forensic Medicine, Ankara University, Ankara, Turkey. drdeniztekin@yahoo.com
authors.forename: Deniz
authors.initials: D
authors.lastname: Tekin
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Kayaalti
authors.forename: Nazan
authors.initials: N
authors.lastname: Dalgic
authors.forename: Erkan
authors.initials: E
authors.lastname: Cakir
authors.forename: Tulin
authors.initials: T
authors.lastname: Soylemezoglu
authors.forename: Busra
authors.initials: B
authors.lastname: Isin Kutlubay
authors.forename: Betul
authors.initials: B
authors.lastname: Aydin Kilic
mesh_terms: D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D058486:Receptors, Purinergic P2X7; D014376:Tuberculosis / Q000235:genetics*; D014421:Turkey
chemical_list: C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7