title: Two new lignans from the roots of Pulsatilla koreana.
abstract: Two new lignans, (2 R,3 R)-2 β-(4''-hydroxy-3''-methoxybenzyl)-3 α-(4'-hydroxy-3'-methoxybenzyl)-γ-butyrolactone 2-O-( β-D-glucopyranoside) (1) and (1 S,2 R,3 S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3',4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC (50) value of 75.9 µM, compounds 8 and 9 had moderate effects with IC (50) values of 182.2 and 166.5 µM, respectively.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea.
authors.forename: To Dao
authors.initials: TD
authors.lastname: Cuong
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Jin-Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Jung-Im
authors.initials: JI
authors.lastname: Huh
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kwack
authors.forename: Tae Suk
authors.initials: TS
authors.lastname: Kang
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Han Su
authors.initials: HS
authors.lastname: Jang
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D005591:Chemical Fractionation; D003165:Complement System Proteins / Q000737:chemistry; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D031946:Pulsatilla / Q000737:chemistry*
chemical_list: C557681:(1S,2R,3S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3',4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate; C557682:(2R,3R)-2beta-(4'-hydroxy-3'-methoxybenzyl)-3alpha-(4'-hydroxy-3'-methoxybenzyl)-gamma-butyrolactone 2-O-(beta-D-glucopyranoside); D017705:Lignans; D010936:Plant Extracts; D003165:Complement System Proteins