Short cationic antimicrobial peptides interact with ATP.
The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. α-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.
Hilpert
Kai
K
Centre for Microbial Diseases and Immunity Research, University of British Columbia, No 2259 Lower Mall Research Station, Vancouver, British Columbia V6T 1Z3, Canada. kai.hilpert@web.de
McLeod
Brett
B
Yu
Jessie
J
Elliott
Melissa R
MR
Rautenbach
Marina
M
Ruden
Serge
S
Bürck
Jochen
J
Muhle-Goll
Claudia
C
Ulrich
Anne S
AS
Keller
Sandro
S
Hancock
Robert E W
RE
D000255:Adenosine Triphosphate / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism* / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D049409:Luciferases, Firefly / Q000378:metabolism
D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; D000255:Adenosine Triphosphate; D049409:Luciferases, Firefly; D004259:DNA-Directed DNA Polymerase