Evaluation of a nanoemulsion-based formulation for respiratory delivery of budesonide by nebulizers.
The aim of this work was to evaluate the in vitro performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budesonide. The in vitro characteristics of the diluted nanoemulsions were then compared with the commercially available suspension of budesonide (Pulmicort Respules®) when nebulized using a jet and a vibrating mesh nebulizer. A smaller MMAD with improved aerosol output was observed in the nanoemulsion preparations compared with the corresponding suspension formulations indicating an improved in vitro performance for the nanoemulsion-based preparations.
Amani
Amir
A
Institute of Pharmaceutical Innovation, School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK. aamani@sina.tums.ac.ir
York
Peter
P
Chrystyn
Henry
H
Clark
Brian J
BJ
D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage* / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004655:Emulsions / Q000138:chemical synthesis*; D008422:Materials Testing; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009330:Nebulizers and Vaporizers; D019141:Respiratory System Agents / Q000008:administration & dosage* / Q000737:chemistry*
D000336:Aerosols; D004655:Emulsions; D019141:Respiratory System Agents