title: Novel use of insulin in continuous-instillation negative pressure wound therapy as "wound chemotherapy".
abstract: Negative pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. A variety of wound chemotherapeutic agents such as insulin, which acts as a growth factor, may prove helpful in treatment as well. We present a case report in which insulin was used as a chemotherapeutic agent in continuous-instillation NPWT. To our knowledge, this is the first report in the literature describing this method of delivery.
authors.affiliation: Southern Arizona Limb Salvage Alliance (SALSA), College of Medicine, University of Arizona, Tucson, Arizona 85724, USA.
authors.forename: Christy L
authors.initials: CL
authors.lastname: Scimeca
authors.forename: Manish
authors.initials: M
authors.lastname: Bharara
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Fisher
authors.forename: Heather
authors.initials: H
authors.lastname: Kimbriel
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Mills
authors.forename: David G
authors.initials: DG
authors.lastname: Armstrong
mesh_terms: D000287:Administration, Topical; D000368:Aged; D048909:Diabetes Complications / Q000188:drug therapy / Q000473:pathology; D017719:Diabetic Foot / Q000188:drug therapy / Q000473:pathology; D049673:History, 20th Century; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000266:history / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage / Q000266:history / Q000627:therapeutic use*; D008297:Male; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin