title: A quantitative structure-activity relationship (QSAR) for a draize eye irritation database.
abstract: A collection of data on the Draize rabbit eye test (Cronin et al., 1994) has been analysed using a set of physicochemical descriptors that we have previously put forward. These descriptors are compound (or solute) parameters as follows: R(2) is an excess molar refraction, pi(2)(H) is the polarizability/dipolarity, Sigmaalpha(2)(H) and Sigmabeta(2)(H) are the effective hydrogen bond acidity and basicity, and logL(16) is a descriptor where L(16) is the vapour-hexadecane solubility at 25 degrees C. When applied to Draize eye scores (DESs) for 38 pure bulk liquids, a very poor equation was obtained. However, when the DES values were correlated as log(DES/P(o)), where P(o) is the liquid vapour pressure, an excellent equation was found. On transforming the calculated log(DES/P(o)) values back to calculated DES values, there was good agreement with the original DES values. It is suggested that the DES/P(o) values refer to transfer of the irritant from the vapour phase to the biophase, and that the success of the present treatment demonstrates that for the pure liquids studied, a major factor in the Draize eye test is simply the transfer of the liquid (or the vapour) to the biological system.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, UK.
authors.forename: M H
authors.initials: MH
authors.lastname: Abraham
authors.forename: R
authors.initials: R
authors.lastname: Kumarsingh
authors.forename: J E
authors.initials: JE
authors.lastname: Cometto-Muniz
authors.forename: W S
authors.initials: WS
authors.lastname: Cain