[The role of modification of fatty acid composition of erythrocyte lipids in pathogenesis of arterial hypertension].
We used liquid chromatography for analysis of fatty acids (FA) in lipids of erythrocytes of patients with hypertensive disease (HD) with normo- (group 1) and hyperlipidemia (group 2). Abnormalities of FA composition of erythrocyte lipids were revealed in both groups. In group 1 we found deficit of polyenic acids of omega-6 family, accumulation of Mead acid - prostanoid precursor with pronounced vasoconstrictor and pro inflammatory properties. In group 2 we noted more profound rearrangement of lipid matrix of erythrocyte membrane manifested as deficiency of omega-3 polyenic acids, accumulation of palmitinic and arachidonic acids. Preponderance of saturated FA in erythrocytes and deficiency of polyenic acids might evidence for pathology of their ligand-receptor transport into the cell. Blockade of active FA transport initiates formation of HD, promotes accumulation of atherogenic fractions of lipoproteins in blood. These results evidence for important pathogenetic role of FA in development of hypertension.
Karaman
Iu K
IuK
Novgorodtseva
T P
TP
Kantur
T A
TA
Antoniuk
M V
MV
Zhukova
N V
NV
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D016718:Arachidonic Acid / Q000032:analysis / Q000378:metabolism*; D050197:Atherosclerosis / Q000378:metabolism; D001693:Biological Transport, Active / Q000502:physiology; D019748:Carbon-Carbon Double Bond Isomerases / Q000032:analysis / Q000172:deficiency / Q000378:metabolism; D002849:Chromatography, Gas; D004910:Erythrocyte Membrane / Q000502:physiology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D018836:Inflammation Mediators / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D019308:Palmitic Acid / Q000032:analysis / Q000378:metabolism*; D014661:Vasoconstriction / Q000502:physiology
D018836:Inflammation Mediators; D008074:Lipoproteins; D016718:Arachidonic Acid; D019308:Palmitic Acid; D019748:Carbon-Carbon Double Bond Isomerases; C105113:polyenoic fatty acid isomerase; D015126:8,11,14-Eicosatrienoic Acid; C010944:mead acid