title: Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.
abstract: We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.
authors.affiliation: Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia.
authors.forename: Nebojsa M
authors.initials: NM
authors.lastname: Lalić
authors.forename: Natasa
authors.initials: N
authors.lastname: Dragasević
authors.forename: Elka
authors.initials: E
authors.lastname: Stefanova
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jotić
authors.forename: Katarina
authors.initials: K
authors.lastname: Lalić
authors.forename: Tanja
authors.initials: T
authors.lastname: Milicić
authors.forename: Igor
authors.initials: I
authors.lastname: Petrović
authors.forename: Marija
authors.initials: M
authors.lastname: Maćesić
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Kostić
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D020754:Spinocerebellar Ataxias / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D007328:Insulin