title: A randomized clinical study comparing reduced-volume oral sulfate solution with standard 4-liter sulfate-free electrolyte lavage solution as preparation for colonoscopy.
abstract: BACKGROUND
  Low-volume bowel preparations for colonoscopy improve tolerability.
  
  
  OBJECTIVE
  We compared the efficacy, tolerability, and safety of a new low-volume sulfate solution with a standard 4-L polyethylene glycol electrolyte lavage solution as bowel preparation for colonoscopy.
  
  
  METHODS
  Multicenter, single-blind, randomized, noninferiority study.
  
  
  METHODS
  Five academic and community endoscopy centers in the United States.
  
  
  METHODS
  One hundred thirty-six outpatients undergoing colonoscopy.
  
  
  METHODS
  Patients were randomized to receive 4 L sulfate-free electrolyte lavage solution (SF-ELS) given the night before colonoscopy versus 12 oz oral sulfate solution (OSS) given in equally divided doses the evening before and the morning of colonoscopy.
  
  
  METHODS
  Successful (ie, good or excellent) bowel preparation.
  
  
  RESULTS
  Successful bowel preparation was more frequent with OSS than with SF-ELS (98.4% vs 89.6%; P = .04). Excellent preparation also was achieved more frequently with OSS (71.4% vs 34.3%; P < .001). Patients receiving OSS had less residual stool in the cecum and ascending colon and less residual fluid in the cecum and ascending, transverse, and descending colon compared with SF-ELS. The percentage of patients with GI side effects and adverse events was not significantly different between the 2 groups.
  
  
  CONCLUSIONS
  The OSS was administered in split doses, whereas the SF-ELS was administered the evening before (which is its FDA-approved regimen).
  
  
  CONCLUSIONS
  Oral sulfate solution is promising as a safe low-volume preparation for colonoscopy. (
  
  
  BACKGROUND
  NCT00856843.).
authors.affiliation: Indiana University Medical Center, Indianapolis, Indiana 46202, USA.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Rex
authors.forename: Jack A
authors.initials: JA
authors.lastname: Di Palma
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Rodriguez
authors.forename: John
authors.initials: J
authors.lastname: McGowan
authors.forename: Mark
authors.initials: M
authors.lastname: Cleveland
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage; D002400:Cathartics / Q000008:administration & dosage; D003113:Colonoscopy / Q000379:methods*; D003672:Defecation / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D016037:Single-Blind Method; D013431:Sulfates / Q000008:administration & dosage*; D007507:Therapeutic Irrigation / Q000379:methods
chemical_list: D000700:Analgesics; D002400:Cathartics; D004338:Drug Combinations; D013431:Sulfates; C012036:sodium sulfate; C031512:potassium sulfate; D008278:Magnesium Sulfate