[The structure and mechanism of the action of type-IB DNA topoisomerases].
DNA topoisomerases responsible for the superspiralization of genomic DNA participate in almost all vitally important cell processes, including replication, transcription, and recombination, and are essential for normal cell functioning. The present review summarizes published data for type-IB topoisomerases. The results concerning the thermodynamic, structural, and kinetic aspects of the functioning of topoisomerases and the peculiarities of the mechanisms of their action have been analyzed for the first time.
Bugreev
D V
DV
Nevinskiĭ
G A
GA
D000818:Animals; D020134:Catalytic Domain; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation
D004264:DNA Topoisomerases, Type I