Optic nerve head registration via hemispherical surface and volume registration.
We present an automated method for nonrigid registration of the optic nerve head (ONH) surfaces extracted from 3-D optical coherence tomography images to give a one-to-one correspondence between two ONH surfaces. This allows development of population-average ONH surfaces, pooling of morphometric data measured on ONH surfaces from multiple subjects into a single chosen template surface, and statistical analysis (cross sectional, or longitudinal, or both) in a common coordinate system. An application of this coordinate system to construct an average ONH shape across an illustrative dataset is demonstrated, and the impact of template selection is assessed.
Gibson
Eli
E
School of Engineering Science, Simon Fraser University, Burnaby, BC V5A1S6, Canada. egibson@robarts.ca
Young
Mei
M
Sarunic
Marinko V
MV
Beg
Mirza Faisal
MF
D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D009898:Optic Disk / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*