On the kinetics of formation of hemozoin, the malaria pigment.
We report on the kinetics of formation of hemozoin as a function of hemin concentration and reaction medium. Evidence is presented for the critical role played by interfacial regions in the efficient conversion of hemin to the malaria pigment.
Pasternack
Robert F
RF
Department of Chemistry & Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA. rpaster1@swarthmore.edu
Munda
Ben
B
Bickford
Abigail
A
Gibbs
Esther J
EJ
Scolaro
Luigi Monsù
LM
D020003:1-Octanol / Q000737:chemistry; D000465:Algorithms; D000818:Animals; D002738:Chloroquine / Q000737:chemistry; D006420:Hemeproteins / Q000737:chemistry* / Q000378:metabolism; D006427:Hemin / Q000737:chemistry* / Q000378:metabolism; D000441:Hexanols / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008288:Malaria / Q000469:parasitology; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010860:Pigments, Biological / Q000737:chemistry* / Q000378:metabolism; D010963:Plasmodium falciparum / Q000378:metabolism; D015800:Protozoan Proteins / Q000737:chemistry* / Q000378:metabolism; D012997:Solvents / Q000737:chemistry
C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D006420:Hemeproteins; D000441:Hexanols; D010714:Phosphatidylethanolamines; D010860:Pigments, Biological; D015800:Protozoan Proteins; D012997:Solvents; C020753:hemozoin; C036260:1-hexanol; D006427:Hemin; D002738:Chloroquine; D020003:1-Octanol; D000432:Methanol