title: [Effect of the recombinant human heat shock protein HSP70 on the biochemical properties of blood in a model of endotoxic shock in rats].
abstract: The protective effects of 70-kDa heat shock proteins (HSP70) were studied following the intravenous administration in rats with endotoxic shock. The antitoxic effects of both bovine HSP70 (bHSP70) and human recombinant HSP70 (hrHSP70) were compared. The preventive uptake of HSP70 decreased the toxic influence of the E. coll endotoxin on the rats' bodies and significantly increased the survival of the animals during the experiment.
authors.forename: V F
authors.initials: VF
authors.lastname: Ostrov
authors.forename: G A
authors.initials: GA
authors.lastname: Slashcheva
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Zharmukhamedova
authors.forename: D G
authors.initials: DG
authors.lastname: Garbuz
authors.forename: M B
authors.initials: MB
authors.lastname: Evgen'ev
authors.forename: A N
authors.initials: AN
authors.lastname: Murashev
mesh_terms: D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D018840:HSP70 Heat-Shock Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012772:Shock, Septic / Q000097:blood* / Q000188:drug therapy / Q000401:mortality
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008070:Lipopolysaccharides; D011994:Recombinant Proteins