title: Local thrombolysis for acute ischemic stroke based on findings of diffusion and perfusion MRI.
abstract: Cerebral per fusion and cerebral tissue integrity were studied in 13 patients with acute embolic stroke in the territory of the internal carotid artery by diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) within six hours after onset. PWI/DWI mismatch lesion was depicted in six patients. MCA was occluded in five of six patients, who underwent local thrombolytic therapy. In three cases, complete restoration of the cerebral circulation was obtained and enlargement of irreversible brain damage compared to initial DWI lesion was prevented. Seven patients without PWI/DWI mismatch did not undergo thrombolytic therapy. Spontaneous reopening of occluded MCA was verified with subsequent cerebral angiography in one of seven patients. CT depicted symptomatic intracerebral hemorrhage in this patient. It is concluded that DWI and PWI in combination are useful in selection of patients for thrombolytic therapy.
authors.affiliation: Department of Neurosurgery, Nagasaki University school of Medicine, Nagasaki; Japan - naoki-k@net.nagasaki-u.ac.jp.
authors.forename: N
authors.initials: N
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Morikawa
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Ishimaru
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Takahata
authors.forename: M
authors.initials: M
authors.lastname: Kaminogo
authors.forename: M
authors.initials: M
authors.lastname: Ochi
authors.forename: S
authors.initials: S
authors.lastname: Shibata