In silico characterization of ligand binding modes in the human histamine H4 receptor and their impact on receptor activation.
Werner
Tim
T
Formerly: Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University Frankfurt/Main, Siesmayerstrasse 70, 60323 Frankfurt/Main, Germany.
Sander
Kerstin
K
Tanrikulu
Yusuf
Y
Kottke
Tim
T
Proschak
Ewgenij
E
Stark
Holger
H
Schneider
Gisbert
G
D054314:Drug Inverse Agonism; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D056004:Molecular Dynamics Simulation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011743:Pyrimidines / Q000737:chemistry; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011968:Receptors, Histamine / Q000378:metabolism*; D000074040:Receptors, Histamine H4
C418607:HRH4 protein, human; D008024:Ligands; D011743:Pyrimidines; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4