title: Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats.
abstract: The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of beta-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
authors.affiliation: Department of Pharmacology and Biotechnology, Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda 508284, Andhra Pradesh, India.
authors.forename: Mohammed Fazil
authors.initials: MF
authors.lastname: Ahmed
authors.forename: Syed Mohammed
authors.initials: SM
authors.lastname: Kazim
authors.forename: Syed Safiullah
authors.initials: SS
authors.lastname: Ghori
authors.forename: Syeda Sughra
authors.initials: SS
authors.lastname: Mehjabeen
authors.forename: Shaik Rasheed
authors.initials: SR
authors.lastname: Ahmed
authors.forename: Shaik Mehboob
authors.initials: SM
authors.lastname: Ali
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ibrahim